Science.gov

Sample records for 3x3 factorial design

  1. A comparison of two factorial designs, a complete 3 x 3 factorial and a central composite rotatable design, for use in binomial response experiments in aquatic toxicology.

    PubMed

    Edginton, Andrea N; Sheridan, Patrick M; Boermans, Herman J; Thompson, Dean G; Holt, John D; Stephenson, Gerald R

    2004-02-01

    Using an amphibian toxicity testing protocol, comparative studies were conducted to assess the predictive precision, degree of similarity of results and efficiency of a central composite rotatable design (CCRD) in relation to a conventional complete 3x3 factorial design. Data were treated with response surface analysis using generalized linear models (glm) and application of profile deviance to generate confidence intervals. Design comparisons were based on studies conducted using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX) protocol to examine the interaction of three toxicants at pH levels ranging from 4.5 to 8.5. Test substances included two commercial herbicide formulations based on glyphosate ([N-phosphonomethyl]glycine) isopropylamine salt (Vision, Rodeo) as well as a polyethoxylated tallow amine surfactant blend (MON 0818), which is a key component of the Vision formulation. The generated models from both the CCRD and the factorial designs produced toxicity estimates similar to each other and to previously published results. Trends were also similar to published results in that the surfactant, MON 0818, was comparatively more toxic than Vision, which was more toxic than Rodeo. Further, all toxicants induced higher mortality under alkaline as opposed to acidic conditions. The CCRD was between 66 and 124% more efficient in the Vision and Rodeo experiments in comparison to the complete 3x3 factorial. Thus, the factorial experiment would have required at least 66% more observations to obtain the same precision. There appeared to be no efficiency gain with the use of the CCRD for MON 0818. The CCRD had tighter confidence intervals in 9 of 12 cases across all test substances. Computer simulations using the experimental data for Vision demonstrated that the LCalpha estimates generated from the 1,000 simulated data sets were very close to the "true" value for both designs. This was based on small bias and mean squared error calculations. Coverage

  2. Design of 3x3 focusing array for heavy ion driver. Final report on CRADA

    SciTech Connect

    Martovetsky, N N

    2005-03-30

    This memo presents a design of a 3 x 3 quadrupole array for HIF. It contains 3 D magnetic field computations of the array build with racetrack coils with and without different shields. It is shown that it is possible to have a low error magnetic field in the cells and shield the stray fields to acceptable levels. The array design seems to be a practical solution to any size array for future multi-beam heavy ion fusion drivers.

  3. Design and fabrication of a 3x3 optoelectronic integrated switch

    NASA Astrophysics Data System (ADS)

    Gouin, Francois L.; Beaulieu, Christian; Noad, Julian P.

    1996-01-01

    With the increasing number of optical networks comes a growing demand for hardware to allow management of interconnections. One of the important elements in a network is the cross-point switch. In this presentation, we describe a GaAs 3 multiplied by 3 optoelectronic switch based on a monolithic optoelectronic integrated circuit which combines a receiver array of MSM photodetectors and three transimpedance amplifiers providing gain for the three output channels. The 3 multiplied by 3 matrix of photodetectors acts at the switching element. The three electrical output channels from this receiver are amplified further by MIC circuits using chip amplifiers. This restores the signal to a level sufficient to drive semiconductor lasers thereby converting the electrical signal back to an optical signal for use as an optical- optical router. A critical step in the switch construction is the delivery of the optical signals to the photodetectors. A special mount was designed and fabricated to support and align the 9 fibers in front of their respective detectors. The switch was evaluated in terms of the responsivity, the isolation and the cross-talk. The overall responsivity exceeds 20 A/W with a bandwidth of 400 MHz, limited by the speed of the detectors. The isolation varies between 33 and 55 dB and depends on the device selected and on the bias condition of the detector in the off-state. The operation of the switch was demonstrated using three television signals.

  4. Multiple Segment Factorial Vignette Designs

    ERIC Educational Resources Information Center

    Ganong, Lawrence H.; Coleman, Marilyn

    2006-01-01

    The multiple segment factorial vignette design (MSFV) combines elements of experimental designs and probability sampling with the inductive, exploratory approach of qualitative research. MSFVs allow researchers to investigate topics that may be hard to study because of ethical or logistical concerns. Participants are presented with short stories…

  5. Apiary B Factory lattice design

    SciTech Connect

    Donald, M.H.R. ); Garren, A.A. )

    1991-04-01

    The Apiary B Factory is a proposed high-intensity electron-positron collider. This paper will present the lattice design for this facility, which envisions two rings with unequal energies in the PEP tunnel. The design has many interesting optical and geometrical features due to the needs to conform to the existing tunnel, and to achieve the necessary emittances, damping times and vacuum. Existing hardware is used to a maximum extent. 8 figs. 1 tab.

  6. Apiary B Factory Lattice Design

    SciTech Connect

    Donald, M.H.R.; Garren, A.A.

    1991-05-03

    The Apiary B Factory is a proposed high-intensity electron-positron collider. This paper presents the lattice design for this facility, which envisions two rings with unequal energies in the PEP tunnel. The design has many interesting optical and geometrical features due to the needs to conform to the existing tunnel, and to achieve the necessary emittances, damping times and vacuum. Existing hardware is used to a maximum extent.

  7. Low-energy neutrino factory design

    SciTech Connect

    Ankenbrandt, C.; Bogacz, S.A.; Bross, A.; Geer, S.; Johnstone, C.; Neuffer, D.; Popovic, M.; /Fermilab

    2009-07-01

    The design of a low-energy (4 GeV) neutrino factory (NF) is described, along with its expected performance. The neutrino factory uses a high-energy proton beam to produce charged pions. The {pi}{sup {+-}} decay to produce muons ({mu}{sup {+-}}), which are collected, accelerated, and stored in a ring with long straight sections. Muons decaying in the straight sections produce neutrino beams. The scheme is based on previous designs for higher energy neutrino factories, but has an improved bunching and phase rotation system, and new acceleration, storage ring, and detector schemes tailored to the needs of the lower energy facility. Our simulations suggest that the NF scheme we describe can produce neutrino beams generated by {approx} 1.4 x 10{sup 21} {mu}{sup +} per year decaying in a long straight section of the storage ring, and a similar number of {mu}{sup -} decays.

  8. B-factory interaction region design

    SciTech Connect

    Sullivan, M.

    1997-06-01

    High luminosity B-factories generally high current (1-3 A) e+e- storage ring accelerators that operate at a center-of-mass energy equal to the mass of the Upsilon (4S) resonance (10.58 GeV). The high beam currents are achieved by storing a large number of bunches (several hundred to several thousand) into each beam. Two designs, the ones located at SLAC and KEK, also have asymmetric beam energies. This imparts a boost to the nearly stationary B mesons formed from the decay of the 4S resonance and allows precision vertex tracking detectors to look for a difference between the decay profiles of the matter and anti-matter B mesons, thereby observing a violation of CP. Bringing the stored beams into collision is one of the major challenges of any B-factory design. In order to achieve high luminosity the beams must be tightly focused. This pushes the final focusing elements close enough to the interaction point to be inside the solenoidal field of the physics detector. In addition, beam-related detector backgrounds from synchrotron radiation and scattered beam particles must be kept below an acceptable level. The major B-factory designs at Cornell University, KEK, and SLAC have all addressed these problems in various ways that depend on specific accelerator design decisions. This paper discusses the accelerator parameters and detector constraints that influence an interaction region (IR) design, as well as how the various IR designs address the challenges posed by a high luminosity B-factory.

  9. The International Design Study for the Neutrino Factory

    SciTech Connect

    Long, K.

    2008-02-21

    The International Design Study for a future Neutrino Factory and super-beam facility (the ISS) established the physics case for a high-precision programme of long-baseline neutrino-oscillation measurements. The ISS also identified baseline specifications for the Neutrino Factory accelerator complex and the neutrino detector systems. This paper summarises the objectives of the International Design Study for the Neutrino Factory (the IDS-NF). The IDS-NF will build on the work of the ISS to deliver a Reference Design Report for the Neutrino Factory by 2012/13 and an Interim Design Report by 2010/11.

  10. Argonne Tau-charm factory collider design study

    SciTech Connect

    Teng, L.C.; Crosbie, E.A.; Norem, J.

    1995-12-01

    The design approach and design principles for a Tau-charm Factory at Argonne were studied. These studies led to a set of preliminary parameters and tentative component features as presented in this paper.

  11. Cost-effective design for a neutrino factory

    SciTech Connect

    Alex Bogacz

    2006-01-01

    There have been active efforts in the U.S., Europe, and Japan on the design of a neutrino factory. This type of facility produces intense beams of neutrinos from the decay of muons in a high-energy storage ring. In the U.S., a second detailed feasibility study (FS2) for a neutrino factory was completed in 2001. Since that report was published, new ideas in bunching, cooling, and acceleration of muon beams have been developed. We have incorporated these ideas into a new facility design, which we designate as study 2B (ST2B), that should lead to significant cost savings over the FS2 design.

  12. A cost-Effective Design for a Neutrino Factory

    SciTech Connect

    Berg, J.S.; Bogacz, S.A.; Caspi, S.; Cobb, J.; Fernow, R.C.; Gallardo, J.C.; Kahn, S.; Kirk, H.; Neuffer, D.; Palmer, R.; Paul, K.; Witte, H.; Zisman, M.

    2006-06-01

    There have been active efforts in the U.S., Europe, and Japan on the design of a Neutrino Factory. This type of facility produces intense beams of neutrinos from the decay of muons in a high energy storage ring. In the U.S., a second detailed Feasibility Study (FS2) for a Neutrino Factory was completed in 2001. Since that report was published, new ideas in bunching, cooling and acceleration of muon beams have been developed. We have incorporated these ideas into a new facility design, which we designate as Study 2B (ST2B), that should lead to significant cost savings over the FS2 design.

  13. Status of the International Design Study of the Neutrino Factory

    SciTech Connect

    Long, Kenneth

    2010-03-30

    The International Design Study for the Neutrino Factory (the IDS-NF) has been established by the Neutrino Factory community to deliver the Reference Design Report (RDR) for the facility by 2012. The baseline design for the facility, developed from that defined in the International Scoping Study of a future Neutrino Factory and super-beam facility (the ISS), will provide 10{sup 21} muon decays per year from 25 GeV stored muon beams. The facility will serve two neutrino detectors; one situated at source-detector distance of between 3000-5000 km, the second at 7000-8000 km. The baseline design for the facility will be described and the status of the IDS-NF effort will be summarised.

  14. Factorial Design: An Eight Factor Experiment Using Paper Helicopters

    NASA Technical Reports Server (NTRS)

    Kozma, Michael

    1996-01-01

    The goal of this paper is to present the analysis of the multi-factor experiment (factorial design) conducted in EG490, Junior Design at Loyola College in Maryland. The discussion of this paper concludes the experimental analysis and ties the individual class papers together.

  15. Interferometer using a 3 x 3 coupler and Faraday mirrors.

    PubMed

    Breguet, J; Gisin, N

    1995-06-15

    A new interferometric setup using a 3 x 3 coupler and two Faraday mirrors is presented. It has the advantages of being built only with passive components, of freedom from the polarization fading problem, and of operation with a LED. It is well suited for sensing time-dependent signals and does not depend on reciprocal or nonreciprocal constant perturbations. PMID:19862044

  16. Bioretention Systems: Partial Factorial Designs for Nitrate Removal

    EPA Science Inventory

    Changes in nutrient loadings are monitored by introducing captured stormwater runoff into eight outdoor rain gardens at EPA’s Urban Water Research Facility in Edison, New Jersey scaled for residential and urban landscapes. The partial factorial design includes non-vegetated meso...

  17. Factorial study of rain garden design for nitrogen removal

    EPA Science Inventory

    Abstract Nitrate (〖NO〗_3^--N ) removal studies in bioretention systems showed great variability in removal rates and in some cases 〖NO〗_3^--N was exported. A 3-way factorial design (2 x 2 x 4) was devised for eight outdoor un-vegetated rain gardens to evaluate the effects of ...

  18. Using Propensity Score Methods to Approximate Factorial Experimental Designs

    ERIC Educational Resources Information Center

    Dong, Nianbo

    2011-01-01

    The purpose of this study is through Monte Carlo simulation to compare several propensity score methods in approximating factorial experimental design and identify best approaches in reducing bias and mean square error of parameter estimates of the main and interaction effects of two factors. Previous studies focused more on unbiased estimates of…

  19. Systems analysis and futuristic designs of advanced biofuel factory concepts.

    SciTech Connect

    Chianelli, Russ; Leathers, James; Thoma, Steven George; Celina, Mathias Christopher; Gupta, Vipin P.

    2007-10-01

    The U.S. is addicted to petroleum--a dependency that periodically shocks the economy, compromises national security, and adversely affects the environment. If liquid fuels remain the main energy source for U.S. transportation for the foreseeable future, the system solution is the production of new liquid fuels that can directly displace diesel and gasoline. This study focuses on advanced concepts for biofuel factory production, describing three design concepts: biopetroleum, biodiesel, and higher alcohols. A general schematic is illustrated for each concept with technical description and analysis for each factory design. Looking beyond current biofuel pursuits by industry, this study explores unconventional feedstocks (e.g., extremophiles), out-of-favor reaction processes (e.g., radiation-induced catalytic cracking), and production of new fuel sources traditionally deemed undesirable (e.g., fusel oils). These concepts lay the foundation and path for future basic science and applied engineering to displace petroleum as a transportation energy source for good.

  20. Evolutionary algorithm for the neutrino factory front end design

    SciTech Connect

    Poklonskiy, Alexey A.; Neuffer, David; /Fermilab

    2009-01-01

    The Neutrino Factory is an important tool in the long-term neutrino physics program. Substantial effort is put internationally into designing this facility in order to achieve desired performance within the allotted budget. This accelerator is a secondary beam machine: neutrinos are produced by means of the decay of muons. Muons, in turn, are produced by the decay of pions, produced by hitting the target by a beam of accelerated protons suitable for acceleration. Due to the physics of this process, extra conditioning of the pion beam coming from the target is needed in order to effectively perform subsequent acceleration. The subsystem of the Neutrino Factory that performs this conditioning is called Front End, its main performance characteristic is the number of the produced muons.

  1. Factorial Design to Optimize Biosurfactant Production by Yarrowia lipolytica

    PubMed Central

    Fontes, Gizele Cardoso; Fonseca Amaral, Priscilla Filomena; Nele, Marcio; Zarur Coelho, Maria Alice

    2010-01-01

    In order to improve biosurfactant production by Yarrowia lipolytica IMUFRJ 50682, a factorial design was carried out. A 24 full factorial design was used to investigate the effects of nitrogen sources (urea, ammonium sulfate, yeast extract, and peptone) on maximum variation of surface tension (ΔST) and emulsification index (EI). The best results (67.7% of EI and 20.9 mN m−1 of ΔST) were obtained in a medium composed of 10 g 1−1 of ammonium sulfate and 0.5 g 1−1 of yeast extract. Then, the effects of carbon sources (glycerol, hexadecane, olive oil, and glucose) were evaluated. The most favorable medium for biosurfactant production was composed of both glucose (4% w/v) and glycerol (2% w/v), which provided an EI of 81.3% and a ΔST of 19.5 mN m−1. The experimental design optimization enhanced ΔEI by 110.7% and ΔST by 108.1% in relation to the standard process. PMID:20368788

  2. Factorial design analysis for sorption of zinc on hydroxyapatite.

    PubMed

    Meski, S; Ziani, S; Khireddine, H; Boudboub, S; Zaidi, S

    2011-02-28

    A factorial design was employed to evaluate the quantitative removal of zinc from aqueous solutions on synthesized hydroxyapatite. The experimental factors and their respective levels studied were the initial zinc concentration in solution (35≤C(Zn)≤85 mg/L), adsorbent dosage (4.5≤C(susp)≤9.5 g/L), Ca/P molar ratio (1.667≤Ca/P≤2) and calcination temperature of hydroxyapatite (600≤T(Cal)≤800 °C). The adsorption parameters were analysed statistically by means of variance analysis by using the STATISTICA software. The experimental results and statistical analysis show that increasing in the calcination temperature from 600 to 800 °C decrease the zinc adsorption whereas the increase of adsorbent dosage increases it. Based on the analysis of variance and the factorial design of experiments, adsorbent dosage has a positive effect on the removal of zinc, whereas zinc concentration, Ca/P molar ratio and calcination temperature have a negative effect on this process. The factorial results also demonstrate the existence of statistically significant binary interactions of the experimental factors. The experimental results were fitted to the Langmuir and Freundlich equations to find out adsorption capacities. In most cases, the results indicate that the sorption data fits well in the Freundlich isotherm model. The results of XRD analysis, pH(PZC) and pH(Final) values indicated that ion exchange and dissolution/precipitation mechanisms predominate for the sorption of zinc on our hydroxyapatite. PMID:21159426

  3. FFAG Designs for the International Design Study for the Neutrino Factory

    SciTech Connect

    Berg, J.S.; Machida, S.

    2009-05-04

    The International Design Study for the Neutrino Factory (IDS-NF) aims to produce a design report for a neutrino factory. One component of that design is a linear nonscaling fixed-field alternating gradient accelerator (FFAG) that will accelerate to the final energy of 25 GeV. An FFAG is used to reduce the machine cost by maximizing the number of passes made through the RF cavities. We present some design options for this FFAG, individually optimized for cost. We study the addition of nonlinear magnets to the lattice to improve the performance of the lattice and consider the negative effects of doing so.

  4. PEP-II: An asymmetric B factory. Conceptual design report

    SciTech Connect

    Not Available

    1993-06-01

    In this report, the authors have described an updated conceptual design for the high-luminosity Asymmetric B Factory (PEP-II) to be built in the PEP tunnel culmination of more than four years of effort aimed at the design and construction of an asymmetric e{sub +}e{sub {minus}} collider capable of achieving a luminosity of L = 3 {times} 10{sup 33} cm{sup {minus}2} s{sup {minus}1}. All aspects of the conceptual design were scrutinized in March 1991 by a DOE technical review committee chaired by Dr. L. Edward Temple. The design was deemed feasible and capable of achieving its physics goals. Furthermore, the cost estimate, schedule, and management plan for the project were fully endorsed by the committee. This updated conceptual design report captures the technical progress since the March 1991 review and reflects the lower cost estimate corresponding to the improved design. Although the PEP-II design has continued to evolve, no technical scope changes have been made that invalidate the conclusion of the DOE review. The configuration adopted utilizes two storage rings, an electron ring operating at 9 GeV and a positron ring at 3.1 GeV, each with a circumference of 2200 m. The high-energy ring is an upgrade of the PEP storage ring at SLAC; all PEP magnets and most power supplies will be reused. The upgrade consists primarily of replacing the PEP vacuum chamber and RF system with newly designed versions optimized for the high-current environment of PEP-II. The low-energy ring will be newly constructed and will be situated atop the high-energy ring in the PEP tunnel. Utilities already installed in the PEP tunnel are largely sufficient to operate the two PEP-II storage rings.

  5. The Skateboard Factory: Curriculum by Design--Oasis Skateboard Factory Q&A with Craig Morrison

    ERIC Educational Resources Information Center

    Pearson, George

    2012-01-01

    Since its opening three years ago, Oasis Skateboard Factory (OSF), founded by teacher Craig Morrison, has attracted considerable media exposure and received a Ken Spencer Award from the CEA for its innovative program. OSF is one of three programs offered by Oasis Alternative Secondary School, one of 22 alternative secondary schools of the Toronto…

  6. Status and Plans for the Accelerator Working Group of the International Design Study of the Neutrino Factory

    SciTech Connect

    Berg, J. Scott

    2010-03-30

    The purpose of the International Design Study of the Neutrino Factory (IDS-NF) is to produce a design report for a neutrino factory in 2013. I report the status of the accelerator design and plans for future studies.

  7. Parameters of a Super-B-Factory Design

    SciTech Connect

    Seeman, J.; Cai, Y.; Ecklund, S.; Fox, J.D.; Heifets, S.A.; Li, N.; McIntosh, P.A.; Novokhatski, A.; Sullivan, M.K.; Teytelman, D.; Wienands, U.; Biagini, M.E.; /Frascati

    2006-03-03

    Parameters are being studied for a high luminosity e{sup +}e{sup -} collider operating at the Upsilon 4S that would deliver a luminosity in the range of 7 to 10 x 10{sup 35}/cm{sup 2}/s. Particle physics studies dictate that a much higher luminosity collider than the present B-Factory accelerators will be needed to answer future new key physics questions. The success of the present B-Factories, PEP-II and KEKB, in producing unprecedented luminosity with very short commissioning times has taught us about the accelerator physics of asymmetric e{sup +}e{sup -} colliders in a new parameter regime. Such a collider could produce an integrated luminosity of 10,000 fb{sup -1} (10 ab{sup -1}) in a running year. A Super-B-Factory [1-8] with 30 to 50 times the performance of the present PEP-II accelerator would incorporate a higher frequency RF system, lower impedance vacuum chambers, higher power synchrotron radiation absorbers, and stronger bunch-by-bunch feedback systems. The present injector based on the SLAC linac needs no improvements and is ready for the Super-B-Factory.

  8. Status of the Tau-Charm Factory Project and aspects of the detector design

    SciTech Connect

    Schindler, R.H.

    1992-10-01

    This paper reviews the status of the Tau-Charm Factory Project being proposed for construction in Spain. The paper also reviews characteristics of the detector design, and the issues surrounding the present choices of technologies.

  9. Comparative genetic analyses of metric traits using diallel and factorial mating designs in bread wheat.

    PubMed

    Virk, D S; Khehra, A S; Virk, P S; Dhillon, B S

    1985-05-01

    For studying the inheritance of metric traits, diallel cross and factorial mating designs are commonly used. Since factorial mating design is less restrictive in crossing plans, the genetic information drawn from it was compared with that from a diallel cross. The comparison was made using graphical, genetic components and combining ability analyses for grain yield, grain weight and spike length in a field experiment of bread wheat (Triticum aestivum L.). Analyses were made on a nine parent diallel cross and a 4 ♀ × 5 ♂ factorial mating design which was sampled from the diallel cross. In general, there was a high degree of agreement between the results obtained from factorial mating design and diallel cross analyses showing thereby that the former provides almost equivalent genetic information to the latter. PMID:24253828

  10. Order-disorder transition of the (3 x 3) Sn/Ge(111) phase

    SciTech Connect

    Floreano, L.; Cvetko, D.; Bavdek, G.; Benes, M.; Morgante, A.

    2001-08-15

    We have measured the long-range order of the {alpha} phase of Sn on the Ge(111) surface throughout the (3 x 3){yields}(3 x 3)R30{sup o} phase transition. The transition has been found of the order-disorder type with a critical temperature T{sub c}{approx}220 K. The expected three-state Potts critical exponents are shown to be consistent with the observed power-law dependence of the (3 x 3) order parameter and its correlation length close to T{sub c}, thus excluding a charge-density wave driven phase transition.

  11. Gaming in the Classroom: An Innovative Way to Teach Factorial Designs

    ERIC Educational Resources Information Center

    Stansbury, Jessica A.; Munro, Geoffrey D.

    2013-01-01

    This study tested the effectiveness of video game use for instruction of factorial designs in a research methods course. Students designed and conducted a mini study, playing "Dance, Dance, Revolution", using video game scores as the dependent variable. A mixed-design analysis of variance revealed a significantly greater increase from pretest to…

  12. Design of Experiments with Multiple Independent Variables: A Resource Management Perspective on Complete and Reduced Factorial Designs

    PubMed Central

    Collins, Linda M.; Dziak, John J.; Li, Runze

    2009-01-01

    An investigator who plans to conduct experiments with multiple independent variables must decide whether to use a complete or reduced factorial design. This article advocates a resource management perspective on making this decision, in which the investigator seeks a strategic balance between service to scientific objectives and economy. Considerations in making design decisions include whether research questions are framed as main effects or simple effects; whether and which effects are aliased (confounded) in a particular design; the number of experimental conditions that must be implemented in a particular design and the number of experimental subjects the design requires to maintain the desired level of statistical power; and the costs associated with implementing experimental conditions and obtaining experimental subjects. In this article four design options are compared: complete factorial, individual experiments, single factor, and fractional factorial designs. Complete and fractional factorial designs and single factor designs are generally more economical than conducting individual experiments on each factor. Although relatively unfamiliar to behavioral scientists, fractional factorial designs merit serious consideration because of their economy and versatility. PMID:19719358

  13. The Muon LINAC for the International Design Study of the Neutrino Factory

    SciTech Connect

    A. Kurup, C. Bontoiu, Morteza Aslaninejad, J. Pozimski, A. Bogacz, V.S. Morozov, Y.R. Roblin, K.B. Beard

    2011-09-01

    The first stage of muon acceleration in the Neutrino Factory utilises a superconducting linac to accelerate muons from 244 MeV to 900 MeV. The linac was split into three types of cryomodules with decreasing magnetic fields and increasing amounts of RF voltage but with the design of the superconducting solenoid and RF cavities being the same for all cryomodules. The current status of the muon linac for the International Design Study for the Neutrino Factory will be presented including a final lattice design of the linac and tracking simulations.

  14. A Sino-Finnish Initiative for Experimental Teaching Practices Using the Design Factory Pedagogical Platform

    ERIC Educational Resources Information Center

    Björklund, Tua A.; Nordström, Katrina M.; Clavert, Maria

    2013-01-01

    The paper presents a Sino-Finnish teaching initiative, including the design and experiences of a series of pedagogical workshops implemented at the Aalto-Tongji Design Factory (DF), Shanghai, China, and the experimentation plans collected from the 54 attending professors and teachers. The workshops aimed to encourage trying out interdisciplinary…

  15. Interim Design Report for the International Design Study for a Neutrino Factory

    SciTech Connect

    Choubey, S.; Gandhi, R.; Goswami, S.; Berg, J.S.; Fernow, R.; Gallardo, J.C.; Gupta, R.; Kirk, H.; Simos, N.; Souchlas, N.; Ellis, M.; /Brunel U. /CERN /Durham U., IPPP /Fermilab /Geneva U. /Glasgow U. /Heidelberg, Max Planck Inst. /Imperial Coll., London /Jefferson Lab /Saha Inst.

    2011-10-01

    The starting point for the International Design Study for the Neutrino Factory (the IDS-NF) was the output of the earlier International Scoping Study for a future Neutrino Factory and super-beam facility (the ISS). The accelerator facility described in section 2 incorporates the improvements that have been derived from the substantial amount of work carried out within the Accelerator Working Group. Highlights of these improvements include: (1) Initial concepts for the implementation of the proton driver at each of the three example sites, CERN, FNAL, and RAL; (2) Detailed studies of the energy deposition in the target area; (3) A reduction in the length of the muon beam phase-rotation and bunching systems; (4) Detailed analyses of the impact of the risk that stray magnetic field in the accelerating cavities in the ionization cooling channel will reduce the maximum operating gradient. Several alternative ionization-cooling lattices have been developed as fallback options to mitigate this technical risk; (5) Studies of particle loss in the muon front-end and the development of strategies to mitigate the deleterious effects of such losses; (6) The development of more complete designs for the muon linac and re-circulating linacs; (7) The development of a design for the muon FFAG that incorporates insertions for injection and extraction; and (8) Detailed studies of diagnostics in the decay ring. Other sub-systems have undergone a more 'incremental' evolution; an indication that the design of the Neutrino Factory has achieved a degree of maturity. The design of the neutrino detectors described in section 3 has been optimized and the Detector Working Group has made substantial improvements to the simulation and analysis of the Magnetized Iron Neutrino Detector (MIND) resulting in an improvement in the overall neutrino-detection efficiency and a reduction in the neutrino-energy threshold. In addition, initial consideration of the engineering of the MIND has generated a

  16. Neutrino Factories

    NASA Astrophysics Data System (ADS)

    Geer, Steve

    2010-06-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture and accelerate O(1021) muons/year. This development prepares the way for a new type of neutrino source : a Neutrino Factory. This article reviews the motivation, design and R&D for a Neutrino Factory.

  17. The future of tau physics and tau-charm detector and factory design

    SciTech Connect

    Perl, M.L.

    1991-02-01

    Future research on the tau lepton requires large statistics, thorough investigation of systematic errors, and direct experimental knowledge of backgrounds. Only a tau-charm factory with a specially designed detector can provide all the experimental conditions to meet these requirements. This paper is a summary of three lectures delivered at the 1991 Lake Louise Winter Institute.

  18. Tests of Hypotheses for Unbalanced Factorial Designs under Various Regression/ Coding Method Combinations.

    ERIC Educational Resources Information Center

    Blair, R. Clifford; Higgins, J.J.

    1978-01-01

    The controversy surrounding regression methods for unbalanced factorial designs is addressed. The statistical hypotheses being tested under the various methods, as well as salient issues in the use of these methods, are discussed. The use of statistical computer packages is also discussed. (Author/JKS)

  19. Using blocked fractional factorial designs to construct discrete choice experiments for healthcare studies.

    PubMed

    Jaynes, Jessica; Wong, Weng-Kee; Xu, Hongquan

    2016-07-10

    Discrete choice experiments (DCEs) are increasingly used for studying and quantifying subjects preferences in a wide variety of healthcare applications. They provide a rich source of data to assess real-life decision-making processes, which involve trade-offs between desirable characteristics pertaining to health and healthcare and identification of key attributes affecting healthcare. The choice of the design for a DCE is critical because it determines which attributes' effects and their interactions are identifiable. We apply blocked fractional factorial designs to construct DCEs and address some identification issues by utilizing the known structure of blocked fractional factorial designs. Our design techniques can be applied to several situations including DCEs where attributes have different number of levels. We demonstrate our design methodology using two healthcare studies to evaluate (i) asthma patients' preferences for symptom-based outcome measures and (ii) patient preference for breast screening services. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26823156

  20. Redirector: Designing Cell Factories by Reconstructing the Metabolic Objective

    PubMed Central

    Church, George M.

    2013-01-01

    Advances in computational metabolic optimization are required to realize the full potential of new in vivo metabolic engineering technologies by bridging the gap between computational design and strain development. We present Redirector, a new Flux Balance Analysis-based framework for identifying engineering targets to optimize metabolite production in complex pathways. Previous optimization frameworks have modeled metabolic alterations as directly controlling fluxes by setting particular flux bounds. Redirector develops a more biologically relevant approach, modeling metabolic alterations as changes in the balance of metabolic objectives in the system. This framework iteratively selects enzyme targets, adds the associated reaction fluxes to the metabolic objective, thereby incentivizing flux towards the production of a metabolite of interest. These adjustments to the objective act in competition with cellular growth and represent up-regulation and down-regulation of enzyme mediated reactions. Using the iAF1260 E. coli metabolic network model for optimization of fatty acid production as a test case, Redirector generates designs with as many as 39 simultaneous and 111 unique engineering targets. These designs discover proven in vivo targets, novel supporting pathways and relevant interdependencies, many of which cannot be predicted by other methods. Redirector is available as open and free software, scalable to computational resources, and powerful enough to find all known enzyme targets for fatty acid production. PMID:23341769

  1. Status of the Super-B factory Design

    SciTech Connect

    Wittmer, W.; Bertsche, K.; Chao, A.; Novokhatski, A.; Nosochkov, Y.; Seeman, J.; Sullivan, M.K.; Wienands, U.; Weathersby, S.; Bogomyagkov, A.V.; Levichev, E.; Nikitin, S.; Piminov, P.; Shatilov, D.; Sinyatkin, S.; Vobly, P.; Okunev, I.N.; Bolzon, B.; Brunetti, L.; Jeremie, A.; Biagini, M.E.; /Frascati /INFN, Pisa /Pisa U. /INFN, Genoa /Genoa U. /CERN /Orsay, LAL /LPSC, Grenoble /Saclay

    2012-05-18

    The SuperB international team continues to optimize the design of an electron-positron collider, which will allow the enhanced study of the origins of flavor physics. The project combines the best features of a linear collider (high single-collision luminosity) and a storage-ring collider (high repetition rate), bringing together all accelerator physics aspects to make a very high luminosity of 10{sup 36} cm{sup -2} sec{sup -1}. This asymmetric-energy collider with a polarized electron beam will produce hundreds of millions of B-mesons at the Y(4S) resonance. The present design is based on extremely low emittance beams colliding at a large Piwinski angle to allow very low {beta}{sub y} without the need for ultra short bunches. Use of crab-waist sextupoles will enhance the luminosity, suppressing dangerous resonances and allowing for a higher beam-beam parameter. The project has flexible beam parameters, improved dynamic aperture, and spin-rotators in the Low Energy Ring for longitudinal polarization of the electron beam at the Interaction Point. Optimized for best colliding-beam performance, the facility may also provide high-brightness photon beams for synchrotron radiation applications.

  2. Using Bayesian variable selection to analyze regular resolution IV two-level fractional factorial designs

    DOE PAGESBeta

    Chipman, Hugh A.; Hamada, Michael S.

    2016-06-02

    Regular two-level fractional factorial designs have complete aliasing in which the associated columns of multiple effects are identical. Here, we show how Bayesian variable selection can be used to analyze experiments that use such designs. In addition to sparsity and hierarchy, Bayesian variable selection naturally incorporates heredity . This prior information is used to identify the most likely combinations of active terms. We also demonstrate the method on simulated and real experiments.

  3. Oxygen Adsorption on the 6H-SiC(0001) (3x3) Surface

    NASA Astrophysics Data System (ADS)

    Cui, Y.; Li, L.

    2001-03-01

    Silicon carbide (SiC) is an attractive semiconductor for applications requiring a wide bandgap, high temperature/high power and chemical inertness. An investigation of the initial stages of oxidation of SiC, therefore, is important for optimizing the growth of thin, insulating oxide layers in SiC devices. In the present work, scanning tunneling microscopy (STM) has been used to study the initial stages of oxygen adsorption at room temperature on the Si-rich (3x3) surface of 6H-SiC(0001). The (3x3) surface is prepared by a two-step method of etching in hydrogen atmosphere at 1500 ^oC and annealing under Si beam in UHV at 950 ^oC. Upon adsorption of oxygen on the (3x3) surface, only one reaction product has been identified in the STM topographs, which appears as bright sites in the empty-state mode. These bright sites are attributed to the oxygen atoms inserted in one of the Si adatom's back bonds. These results and their implications for oxide growth on SiC will be presented at the meeting.

  4. Design of Experiments with Multiple Independent Variables: A Resource Management Perspective on Complete and Reduced Factorial Designs

    ERIC Educational Resources Information Center

    Collins, Linda M.; Dziak, John J.; Li, Runze

    2009-01-01

    An investigator who plans to conduct an experiment with multiple independent variables must decide whether to use a complete or reduced factorial design. This article advocates a resource management perspective on making this decision, in which the investigator seeks a strategic balance between service to scientific objectives and economy.…

  5. Design of Experiments Study of Hydroxyapatite Synthesis for Orthopaedic Application Using Fractional Factorial Design

    NASA Astrophysics Data System (ADS)

    Kehoe, S.; Ardhaoui, M.; Stokes, J.

    2011-11-01

    Hydroxyapatite, (HAp), Ca10(PO4)6(OH)2, is a naturally occurring mineral found in the inorganic component of enamel and human bone, consequently the present research focus is its ability to promote bone growth onto femoral implants when the HAp powder is sprayed using plasma thermal spraying. As the sprayed deposit requires certain mechanical and biological performances, the characteristics of the starting HAp powder will provide these properties. Hap powders were synthesized via a wet chemical precipitation technique using a Fractional Factorial, Resolution IV, two-level experimental design to evaluate the critical process parameters (reagent addition rate, reaction temperature, stirring speed, ripening time, initial calcium concentration, and the presence of an inert atmosphere) and their effect (main and interaction) on the final HAp powder characteristics, such as, phase composition, purity, crystallinity, crystallite size, lattice parameters, particle size, and particle size distribution. All six selected variables investigated, showed an influence (either as a minor or major significance) on one or more of the responses investigated, either as a main or interaction effect. However, both the ripening time and the stirring speed were found to significantly affect the majority of the five responses, with the reaction temperature also having a significant effect on the final phase composition, lattice parameters, and particle size.

  6. 3(3) factorial design-based optimization of the formulation of nitrofurantoin microcapsules.

    PubMed

    Karasulu, H Y; Ertan, G; Günerï, T

    1996-01-01

    A microcapsule form of nitrofurantoin was prepared by a simple coacervation method with carboxymethylcellulose and aluminium sulfate. 3(3) factorial design was performed for three independent variables, namely, the particle size of the drug, the size of the microcapsules and the pH of the dissolution medium. The dissolution tests with the formulated microcapsules were carried out according to the United States Pharmacopeia XXII rotating basket method at pH 1.2, 5, and 7.5, which represent the pH of gastrointestinal fluids. Release data were examined kinetically and the ideal kinetic models were estimated and t(63.2) values obtained from RRSBW distribution were used in the factorial design experiment. The influence of the independent variables on the dissolution of nitrofurantoin microcapsules could be expressed as the pH of the dissolution medium > particle size of the microcapsule > particle size of nitrofurantoin. The other aim of this study was to evaluate microcapsule formulation in terms of the United States Pharmacopeia criteria with a minimum of experiments. Our findings suggest that dosage forms which comply with the pharmacopoeia criteria for dissolution can be prepared and selected by factorial design. PMID:8861827

  7. Vacuum system design for the PEP-II B Factory High-Energy Ring

    SciTech Connect

    Perkins, C.; Bostic, D.; Daly, E.

    1994-06-01

    The design of the vacuum system for the PEP-II B Factory High-Energy Ring is reviewed. The thermal design and vacuum requirements are particularly challenging in PEP-II due to high stored beam currents up to 3.0 amps in 1658 bunches. The vacuum chambers for the HER arcs are fabricated by electron beam welding extruded copper sections up to 6 m long. Design of these chambers and the vacuum PumPing configuration is described with results from vacuum and thermal analyses.

  8. Sensitivity Analysis of the Thermal Response of 9975 Packaging Using Factorial Design Methods

    SciTech Connect

    Gupta, Narendra K.

    2005-10-31

    A method is presented for using the statistical design of experiment (2{sup k} Factorial Design) technique in the sensitivity analysis of the thermal response (temperature) of the 9975 radioactive material packaging where multiple thermal properties of the impact absorbing and fire insulating material Celotex and certain boundary conditions are subject to uncertainty. 2{sup k} Factorial Design method is very efficient in the use of available data and is capable of analyzing the impact of main variables (Factors) and their interactions on the component design. The 9975 design is based on detailed finite element (FE) analyses and extensive proof testing to meet the design requirements given in 10CFR71 [1]. However, the FE analyses use Celotex thermal properties that are based on published data and limited experiments. Celotex is an orthotropic material that is used in the home building industry. Its thermal properties are prone to variation due to manufacturing and fabrication processes, and due to long environmental exposure. This paper will evaluate the sensitivity of variations in thermal conductivity of the Celotex, convection coefficient at the drum surface, and drum emissivity (herein called Factors) on the thermal response of 9975 packaging under Normal Conditions of Transport (NCT). Application of this methodology will ascertain the robustness of the 9975 design and it can lead to more specific and useful understanding of the effects of various Factors on 9975 performance.

  9. Nanostructured lipid carriers as a potential vehicle for Carvedilol delivery: Application of factorial design approach.

    PubMed

    Patil, Ganesh B; Patil, Nandkishor D; Deshmukh, Prashant K; Patil, Pravin O; Bari, Sanjay B

    2016-01-01

    Present invention relates to design of nanostructured lipid carriers (NLC) to augment oral bioavailability of Carvedilol (CAR). In this attempt, formulations of CAR-NLCs were prepared with glyceryl-monostearate (GMS) as a lipid, poloxamer 188 as a surfactant and tween 80 as a co-surfactant using high pressure homogenizer by 2(3) factorial design approach. Formed CAR-NLCs were assessed for various performance parameters. Accelerated stability studies demonstrated negligible change in particle size and entrapment efficiency, after storage at specified time up to 3 months. The promising findings in this investigation suggest the practicability of these systems for enhancement of bioavailability of drugs like CAR. PMID:24866725

  10. The metric comparability of meta-analytic effect-size estimators from factorial designs.

    PubMed

    Gillett, Raphael

    2003-12-01

    The primary studies in a meta-analysis of standardized mean differences generally include a mixture of single-factor t tests and multifactor analysis of variance designs. Accordingly, there is a need for effect-size measures in multifactor designs that are metrically comparable with measures in single-factor t tests. Two models, the variance-preservation model and the variance-reduction model, provide a formal description of the 2 principal routes by which a single-factor design may evolve into a higher order factorial design. New metrically comparable effect-size measures and estimators are developed for designs that contain variance-preservation factors, variance-reduction factors, or a mixture of both types of factors. A statistical test for checking the validity of model assumptions is presented. PMID:14664680

  11. DESIGN AND LAYOUT CONCEPTS FOR COMPACT, FACTORY-PRODUCED, TRANSPORTABLE, GENERATION IV REACTOR SYSTEMS

    SciTech Connect

    Mynatt Fred R.; Townsend, L.W.; Williamson, Martin; Williams, Wesley; Miller, Laurence W.; Khan, M. Khurram; McConn, Joe; Kadak, Andrew C.; Berte, Marc V.; Sawhney, Rapinder; Fife, Jacob; Sedler, Todd L.; Conway, Larry E.; Felde, Dave K.

    2003-11-12

    The purpose of this research project is to develop compact (100 to 400 MWe) Generation IV nuclear power plant design and layout concepts that maximize the benefits of factory-based fabrication and optimal packaging, transportation and siting. The reactor concepts selected were compact designs under development in the 2000 to 2001 period. This interdisciplinary project was comprised of three university-led nuclear engineering teams identified by reactor coolant type (water, gas, and liquid metal) and a fourth Industrial Engineering team. The reactors included a Modular Pebble Bed helium-cooled concept being developed at MIT, the IRIS water-cooled concept being developed by a team led by Westinghouse Electric Company, and a Lead-Bismuth-cooled concept developed by UT. In addition to the design and layout concepts this report includes a section on heat exchanger manufacturing simulations and a section on construction and cost impacts of proposed modular designs.

  12. Nonmedical influences on medical decision making: an experimental technique using videotapes, factorial design, and survey sampling.

    PubMed Central

    Feldman, H A; McKinlay, J B; Potter, D A; Freund, K M; Burns, R B; Moskowitz, M A; Kasten, L E

    1997-01-01

    OBJECTIVE: To study nonmedical influences on the doctor-patient interaction. A technique using simulated patients and "real" doctors is described. DATA SOURCES: A random sample of physicians, stratified on such characteristics as demographics, specialty, or experience, and selected from commercial and professional listings. STUDY DESIGN: A medical appointment is depicted on videotape by professional actors. The patient's presenting complaint (e.g., chest pain) allows a range of valid interpretation. Several alternative versions are taped, featuring the same script with patient-actors of different age, sex, race, or other characteristics. Fractional factorial design is used to select a balanced subset of patient characteristics, reducing costs without biasing the outcome. DATA COLLECTION: Each physician is shown one version of the videotape appointment and is asked to describe how he or she would diagnose or treat such a patient. PRINCIPAL FINDINGS: Two studies using this technique have been completed to date, one involving chest pain and dyspnea and the other involving breast cancer. The factorial design provided sufficient power, despite limited sample size, to demonstrate with statistical significance various influences of the experimental and stratification variables, including the patient's gender and age and the physician's experience. Persistent recruitment produced a high response rate, minimizing selection bias and enhancing validity. CONCLUSION: These techniques permit us to determine, with a degree of control unattainable in observational studies, whether medical decisions as described by actual physicians and drawn from a demographic or professional group of interest, are influenced by a prescribed set of nonmedical factors. PMID:9240285

  13. CHF prediction of GE 3 x 3 rod bundle based on BODYFIT-2PE. [BWR

    SciTech Connect

    Chien, T.H.; Chen, B.C.J.; Sha, W.T.; Kim, J.H.

    1983-01-01

    A General Electric 3 x 3 rod bundle critical heat flux (CHF) experiment was analyzed by using BODYFIT-2PE. (Boundary-fitted coordinates-2 phase partially elliptic). BODYFIT-2PE is a three-dimensional, steady-state/transient, single-phase rod-bundle thermal-hydraulic computer program based on the technique of boudnary-fitted coordinate system. In this coordinate system, all the physical boundaries are made to be coincident with the coordinate lines so that the boundary conditions, such as constant heat fluxes and zero velocities, can be accurately represented without interpolation. However, the transformed coordinate system is not unique for a given geometric configuration. The more orthogonal the coordinates are, the faster the rates of calculational convergence. The generation of the transformed coordinates is based on the solution of a set of second-order partial differential equations, subject to a set of geometric boundary conditions. A simple Laplacian is used in the present study.

  14. Neutrino factories

    SciTech Connect

    Soler, F. J. P.

    2015-07-15

    The Neutrino Factory is a facility that produces neutrino beams with a well-defined flavour content and energy spectrum from the decay of intense, high-energy, stored muon beams to establish CP violation in the neutrino sector. The International Design Study for the Neutrino Factory (the IDS-NF) is providing a Reference Design Report (RDR) for the facility. The present design is optimised for the recent measurements of θ{sub 13}. The accelerator facility will deliver 10{sup 21} muon decays per year from 10 GeV stored muon beams. The straight sections of the storage ring point to a 100 kton Magnetised Iron Neutrino Detector (MIND) at a distance of 2000-2500 km from the source. The accuracy in the value of δ{sub CP} that a Neutrino Factory can achieve and the δ{sub CP} coverage is unrivalled by other future facilities. Staging scenarios for the Neutrino Factory deliver facilities that can carry out physics at each stage. In the context of Fermilab, such a scenario would imply in the first stage the construction of a small storage ring, nuSTORM, to carry out neutrino cross-section and sterile neutrino measurements and to perform a programme of 6D muon cooling R&D. The second stage is the construction of a 5 GeV Neutrino Factory (nuMAX) pointing to the Sanford Underground Research Facility at Homestake and the final stage would use many of the components of this facility to construct a Muon Collider, initially as a 126 GeV CM Higgs Factory, which may be upgraded to a multi-TeV Muon Collider if required.

  15. Neutrino factories

    NASA Astrophysics Data System (ADS)

    Soler, F. J. P.

    2015-07-01

    The Neutrino Factory is a facility that produces neutrino beams with a well-defined flavour content and energy spectrum from the decay of intense, high-energy, stored muon beams to establish CP violation in the neutrino sector. The International Design Study for the Neutrino Factory (the IDS-NF) is providing a Reference Design Report (RDR) for the facility. The present design is optimised for the recent measurements of θ13. The accelerator facility will deliver 1021 muon decays per year from 10 GeV stored muon beams. The straight sections of the storage ring point to a 100 kton Magnetised Iron Neutrino Detector (MIND) at a distance of 2000-2500 km from the source. The accuracy in the value of δCP that a Neutrino Factory can achieve and the δCP coverage is unrivalled by other future facilities. Staging scenarios for the Neutrino Factory deliver facilities that can carry out physics at each stage. In the context of Fermilab, such a scenario would imply in the first stage the construction of a small storage ring, nuSTORM, to carry out neutrino cross-section and sterile neutrino measurements and to perform a programme of 6D muon cooling R&D. The second stage is the construction of a 5 GeV Neutrino Factory (nuMAX) pointing to the Sanford Underground Research Facility at Homestake and the final stage would use many of the components of this facility to construct a Muon Collider, initially as a 126 GeV CM Higgs Factory, which may be upgraded to a multi-TeV Muon Collider if required.

  16. Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design

    PubMed Central

    Andalib, Sare; Varshosaz, Jaleh; Hassanzadeh, Farshid; Sadeghi, Hojjat

    2012-01-01

    Background: Nanostructured lipid carriers (NLC) are a mixture of solid and liquid lipids or oils as colloidal carrier systems that lead to an imperfect matrix structure with high ability for loading water soluble drugs. The aim of this study was to find the best proportion of liquid and solid lipids of different types for optimization of the production of LDL targeted NLCs used in carrying 5-Fu by the emulsification-solvent evaporation method. Materials and Methods: The influence of the lipid type, cholesterol or cholesteryl stearate for targeting LDL receptors, oil type (oleic acid or octanol), lipid and oil% on particle size, surface charge, drug loading efficiency, and drug released percent from the NLCs were studied by a full factorial design. Results: The NLCs prepared by 54.5% cholesterol and 25% of oleic acid, showed optimum results with particle size of 105.8 nm, relatively high zeta potential of –25 mV, drug loading efficiency of 38% and release efficiency of about 40%. Scanning electron microscopy of nanoparticles confirmed the results of dynamic light scattering method used in measuring the particle size of NLCs. Conclusions: The optimization method by a full factorial statistical design is a useful optimization method for production of nanostructured lipid carriers. PMID:23326776

  17. Factorial design studies of antiretroviral drug-loaded stealth liposomal injectable: PEGylation, lyophilization and pharmacokinetic studies

    NASA Astrophysics Data System (ADS)

    Sudhakar, Beeravelli; Krishna, Mylangam Chaitanya; Murthy, Kolapalli Venkata Ramana

    2016-01-01

    The aim of the present study was to formulate and evaluate the ritonavir-loaded stealth liposomes by using 32 factorial design and intended to delivered by parenteral delivery. Liposomes were prepared by ethanol injection method using 32 factorial designs and characterized for various physicochemical parameters such as drug content, size, zeta potential, entrapment efficiency and in vitro drug release. The optimization process was carried out using desirability and overlay plots. The selected formulation was subjected to PEGylation using 10 % PEG-10000 solution. Stealth liposomes were characterized for the above-mentioned parameters along with surface morphology, Fourier transform infrared spectrophotometer, differential scanning calorimeter, stability and in vivo pharmacokinetic studies in rats. Stealth liposomes showed better result compared to conventional liposomes due to effect of PEG-10000. The in vivo studies revealed that stealth liposomes showed better residence time compared to conventional liposomes and pure drug solution. The conventional liposomes and pure drug showed dose-dependent pharmacokinetics, whereas stealth liposomes showed long circulation half-life compared to conventional liposomes and pure ritonavir solution. The results of statistical analysis showed significance difference as the p value is (<0.05) by one-way ANOVA. The result of the present study revealed that stealth liposomes are promising tool in antiretroviral therapy.

  18. Neutrino Factories

    SciTech Connect

    Geer, Steve; /Fermilab

    2010-01-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture and accelerate O(10{sup 21}) muons/year. This prepares the way for a Neutrino Factory (NF) in which high energy muons decay within the straight sections of a storage ring to produce a beam of neutrinos and anti-neutrinos. The NF concept was proposed in 1997 at a time when the discovery that the three known types of neutrino ({nu}{sub e}, {nu}{sub {mu}}, {nu}{sub {tau}}) can change their flavor as they propagate through space (neutrino oscillations) was providing a first glimpse of physics beyond the Standard Model. This development prepares the way for a new type of neutrino source: a Neutrino Factory. This article reviews the motivation, design and R&D for a Neutrino Factory.

  19. Neutrino factory

    SciTech Connect

    Bogomilov, M.; Matev, R.; Tsenov, R.; Dracos, M.; Bonesini, M.; Palladino, V.; Tortora, L.; Mori, Y.; Planche, T.; Lagrange, J. B.; Kuno, Y.; Benedetto, E.; Efthymiopoulos, I.; Garoby, R.; Gilardoini, S.; Martini, M.; Wildner, E.; Prior, G.; Blondel, A.; Karadzhow, Y.; Ellis, M.; Kyberd, P.; Bayes, R.; Laing, A.; Soler, F. J. P.; Alekou, A.; Apollonio, M.; Aslaninejad, M.; Bontoiu, C.; Jenner, L. J.; Kurup, A.; Long, K.; Pasternak, J.; Zarrebini, A.; Poslimski, J.; Blackmore, V.; Cobb, J.; Tunnell, C.; Andreopoulos, C.; Bennett, J. R.J.; Brooks, S.; Caretta, O.; Davenne, T.; Densham, C.; Edgecock, T. R.; Fitton, M.; Kelliher, D.; Loveridge, P.; McFarland, A.; Machida, S.; Prior, C.; Rees, G.; Rogers, C.; Rooney, M.; Thomason, J.; Wilcox, D.; Booth, C.; Skoro, G.; Back, J. J.; Harrison, P.; Berg, J. S.; Fernow, R.; Gallardo, J. C.; Gupta, R.; Kirk, H.; Simos, N.; Stratakis, D.; Souchlas, N.; Witte, H.; Bross, A.; Geer, S.; Johnstone, C.; Makhov, N.; Neuffer, D.; Popovic, M.; Strait, J.; Striganov, S.; Morfín, J. G.; Wands, R.; Snopok, P.; Bagacz, S. A.; Morozov, V.; Roblin, Y.; Cline, D.; Ding, X.; Bromberg, C.; Hart, T.; Abrams, R. J.; Ankenbrandt, C. M.; Beard, K. B.; Cummings, M. A.C.; Flanagan, G.; Johnson, R. P.; Roberts, T. J.; Yoshikawa, C. Y.; Graves, V. B.; McDonald, K. T.; Coney, L.; Hanson, G.

    2014-12-08

    The properties of the neutrino provide a unique window on physics beyond that described by the standard model. The study of subleading effects in neutrino oscillations, and the race to discover CP-invariance violation in the lepton sector, has begun with the recent discovery that theta(13) > 0. The measured value of theta(13) is large, emphasizing the need for a facility at which the systematic uncertainties can be reduced to the percent level. The neutrino factory, in which intense neutrino beams are produced from the decay of muons, has been shown to outperform all realistic alternatives and to be capable of making measurements of the requisite precision. Its unique discovery potential arises from the fact that only at the neutrino factory is it practical to produce high-energy electron (anti) neutrino beams of the required intensity. This paper presents the conceptual design of the neutrino factory accelerator facility developed by the European Commission Framework Programme 7 EURO nu. Design Study consortium. EURO nu coordinated the European contributions to the International Design Study for the Neutrino Factory (the IDS-NF) collaboration. The EURO nu baseline accelerator facility will provide 10(21) muon decays per year from 12.6 GeV stored muon beams serving a single neutrino detector situated at a source-detector distance of between 1 500 km and 2 500 km. A suite of near detectors will allow definitive neutrino-scattering experiments to be performed.

  20. Neutrino factory

    DOE PAGESBeta

    Bogomilov, M.; Matev, R.; Tsenov, R.; Dracos, M.; Bonesini, M.; Palladino, V.; Tortora, L.; Mori, Y.; Planche, T.; Lagrange, J. B.; et al

    2014-12-08

    The properties of the neutrino provide a unique window on physics beyond that described by the standard model. The study of subleading effects in neutrino oscillations, and the race to discover CP-invariance violation in the lepton sector, has begun with the recent discovery that theta(13) > 0. The measured value of theta(13) is large, emphasizing the need for a facility at which the systematic uncertainties can be reduced to the percent level. The neutrino factory, in which intense neutrino beams are produced from the decay of muons, has been shown to outperform all realistic alternatives and to be capable ofmore » making measurements of the requisite precision. Its unique discovery potential arises from the fact that only at the neutrino factory is it practical to produce high-energy electron (anti) neutrino beams of the required intensity. This paper presents the conceptual design of the neutrino factory accelerator facility developed by the European Commission Framework Programme 7 EURO nu. Design Study consortium. EURO nu coordinated the European contributions to the International Design Study for the Neutrino Factory (the IDS-NF) collaboration. The EURO nu baseline accelerator facility will provide 10(21) muon decays per year from 12.6 GeV stored muon beams serving a single neutrino detector situated at a source-detector distance of between 1 500 km and 2 500 km. A suite of near detectors will allow definitive neutrino-scattering experiments to be performed.« less

  1. Lattice design for the high energy ring of the SLAC B-Factory (PEP-II)

    SciTech Connect

    Donald, M.H.R.; Cai, Y.; Irwin, J.

    1995-04-01

    The design of the lattice for the High Energy Ring (HER) of the SLAC B-Factory has several special features, notably provision for octupole compensation of amplitude dependent tune shift effects and a beta-beat scheme for semi-local chromaticity correction. In the arcs adjacent to the interaction point (IP) the beta functions are enhanced to allow the use of non-interlaced sextupoles to compensate the chromaticity of the interaction region. A closed bump of beta {open_quotes}mismatch{close_quotes} is generated by two vertically focusing quadrupoles spaced 2 betatron wavelengths apart. The beta-beat has two advantages: it enhances the ratio between the horizontal and vertical beta functions at the sextupoles and, because of the locally higher beta function, allows weaker sextupoles to be used. The standard design uses a 60 degree/cell lattice but a 90 degree/cell lattice may also be used if lower emittances and momentum compaction factor are desired.

  2. Design and Factory Test of the E /E- Frascati Linear Accelerator for DAFNE

    SciTech Connect

    Anamkath, H.; Lyons, S.; Nett, D.; Treas, P.; Whitham, K.; Zante, T.; Miller, R.; Boni, R.; Hsieh, H.; Sannibale, F.; Vescovi, M.; Vignola, G.; /Frascati

    2011-11-28

    The electron-positron accelerator for the DAFNE project has been built and is in test at Titan Beta in Dublin, CA. This S-Band RF linac system utilizes four 45 MW sledded klystrons and 16-3 m accelerating structures to achieve the required performance. It delivers a 4 ampere electron beam to the positron converter and accelerates the resulting positrons to 550 MeV. The converter design uses a 4.3T pulsed tapered flux compressor along with a pseudo-adiabatic tapered field to a 5 KG solenoid over the first two positron accelerating sections. Quadrupole focusing is used after 100 MeV. The system performance is given in Table 1. This paper briefly describes the design and development of the various subassemblies in this system and gives the initial factory test data.

  3. Computer modelling of bunch-by-bunch feedback for the SLAC B-factory design

    SciTech Connect

    Briggs, D.; Fox, J.D.; Hosseini, W.; Klaisner, L.; Morton, P.; Pellegrin, J.L.; Thompson, K.A. ); Lambertson, G. )

    1991-05-01

    The SLAC B-factory design, with over 1600 high current bunches circulating in each ring, will require a feedback system to avoid coupled-bunch instabilities. A computer model of the storage ring, including the RF system, wave fields, synchrotron radiation loss, and the bunch-by-bunch feedback system is presented. The feedback system model represents the performance of a fast phase detector front end (including system noise and imperfections), a digital filter used to generate a correction voltage, and a power amplifier and beam kicker system. The combined ring-feedback system model is used to study the feedback system performance required to suppress instabilities and to quantify the dynamics of the system. Results are presented which show the time development of coupled bunch instabilities and the damping action of the feedback system. 3 refs., 5 figs., 2 tabs.

  4. The Role of Synthetic Biology in the Design of Microbial Cell Factories for Biofuel Production

    PubMed Central

    Colin, Verónica Leticia; Rodríguez, Analía; Cristóbal, Héctor Antonio

    2011-01-01

    Insecurity in the supply of fossil fuels, volatile fuel prices, and major concerns regarding climate change have sparked renewed interest in the production of fuels from renewable resources. Because of this, the use of biodiesel has grown dramatically during the last few years and is expected to increase even further in the future. Biodiesel production through the use of microbial systems has marked a turning point in the field of biofuels since it is emerging as an attractive alternative to conventional technology. Recent progress in synthetic biology has accelerated the ability to analyze, construct, and/or redesign microbial metabolic pathways with unprecedented precision, in order to permit biofuel production that is amenable to industrial applications. The review presented here focuses specifically on the role of synthetic biology in the design of microbial cell factories for efficient production of biodiesel. PMID:22028591

  5. Novel Starch-PVA Polymer for Microparticle Preparation and Optimization Using Factorial Design Study

    PubMed Central

    Chattopadhyay, Helen; De, Amit Kumar; Datta, Sriparna

    2015-01-01

    The aim of our present work was to optimize the ratio of a very novel polymer, starch-polyvinyl alcohol (PVA), for controlled delivery of Ornidazole. Polymer-coated drug microparticles were prepared by emulsion method. Microscopic study, scanning electron microscopic study, and atomic force microscopic study revealed that the microparticles were within 10 micrometers of size with smooth spherical shape. The Fourier transform infrared spectroscopy showed absence of drug polymer interaction. A statistical 32 full factorial design was used to study the effect of different concentration of starch and PVA on the drug release profile. The three-dimensional plots gave us an idea about the contribution of each factor on the release kinetics. Hence this novel polymer of starch and polyvinyl alcohol can be utilized for control release of the drug from a targeted delivery device. PMID:27347511

  6. Biosorption of pentachlorophenol by fungal biomass from aqueous solutions: a factorial design analysis.

    PubMed

    Mathialagan, T; Viraraghavan, T

    2005-05-01

    A 2(5-1) fractional factorial design was conducted for the biosorption of pentachlorophenol (PCP) using Aspergillus niger biomass. Effects of several factors on the percentage removal of PCP from aqueous solutions were evaluated. These factors were as follows: type of biomass (autoclaved- chemically modified); pH (3-11); concentration (1-10 mgl(-1)); temperature (6-32 degrees C); and dissolved oxygen (2.5-20 mgl(-1)). Time of shaking (equilibrium time), volume of the solution and mass of biomass were kept constant. The results showed that type of biomass and pH had a larger impact on the removal of PCP. Concentration of PCP in the aqueous solution, temperature, and dissolved oxygen only marginally affected the removal efficiency of PCP. PMID:15974275

  7. Advanced Envelope Research for Factory Built Housing, Phase 3 -- Design Development and Prototyping

    SciTech Connect

    Levy, E.; Kessler, B.; Mullens, M.; Rath, P.

    2014-01-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet the thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.

  8. Advanced Envelope Research for Factory Built Housing, Phase 3. Design Development and Prototyping

    SciTech Connect

    Levy, E.; Kessler, B.; Mullens, M.; Rath, P.

    2014-01-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet the thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.

  9. Design of experiment (DOE) study of biodegradable magnesium alloy synthesized by mechanical alloying using fractional factorial design

    NASA Astrophysics Data System (ADS)

    Salleh, Emee Marina; Ramakrishnan, Sivakumar; Hussain, Zuhailawati

    2014-06-01

    The biodegradable nature of magnesium (Mg) makes it a most highlighted and attractive to be used as implant materials. However, rapid corrosion rate of Mg alloys especially in electrolytic aqueous environment limits its performance. In this study, Mg alloy was mechanically milled by incorporating manganese (Mn) as alloying element. An attempt was made to study both effect of mechanical alloying and subsequent consolidation processes on the bulk properties of Mg-Mn alloys. 2k-2 factorial design was employed to determine the significant factors in producing Mg alloy which has properties closes to that of human bones. The design considered six factors (i.e. milling time, milling speed, weight percentage of Mn, compaction pressure, sintering temperature and sintering time). Density and hardness were chosen as the responses for assessing the most significant parameters that affected the bulk properties of Mg-Mn alloys. The experimental variables were evaluated using ANOVA and regression model. The main parameter investigated was compaction pressure.

  10. Optimization of protocell of silica nanoparticles using 3² factorial designs.

    PubMed

    Kaur, Gunjeet; Rath, Goutam; Heer, Hemraj; Goyal, Amit K

    2012-03-01

    The purpose of the research is to carry out systemic optimization of protocells (liposomes entrapped with silica particles). Optimization was carried out using 3(2) factorial designs for the selection of the optimized protocell composition with reference to particle size distribution and zetapotential. This design was carried out to study the effect of independent variables such as molar ratio of phosphatidylcholine to cholesterol and concentration of silica nanoparticles. A total of nine formulations of protocells were prepared and analyzed using Design expert® software from Stat-Ease, Inc. (Version 8.0.4.1 trial 2010) for the selection of the optimized combination. Contour plots were constructed with independent variables like size and potential. Protocell with 7:3 ratio of phosphatidyl choline to cholesterol and 0.5 mg/ml of silica nanoparticles demonstrated better colloidal behaviors. The findings obtained from the software corresponding to independent variables demonstrated accurate means for the optimization of the pharmaceutical formulations. PMID:22173376

  11. Complete factorial design experiment for 3D load cell instrumented crank validation.

    PubMed

    Omar, Valle-Casas; Rafael, Dalazen; Vinicius, Cene; Alexandre, Balbinot

    2015-08-01

    Developing of instrumentation systems for sport medicine is a promising area, that's why this research evaluates the design of a new instrumented crank arm prototype for a race bicycle projecting an experiment for indoor - outdoor comparison. This study investigated the viability of an instrumentation 3D load cell for force measurement crank, implementing a design of experiment. A Complete factorial design experiment was developed for data validation, with an Analysis of Variance (ANOVA) throwing significant results for controlled factors with response variables rms, mean and variance. A software routine allowed to obtained system variables metrics for Symmetry and Cadence analysis, which came out from Effective force bilateral comparing and speed computation. Characterization allowed achieving calibration curves that were used for data conversion in force projection channels with a linearity error of 0.29% (perpendicular), 0.55% (parallel) and 0.10% (lateral). Interactions of factors resulted significant mainly for indoor tests in symmetry and cadence was significant in interactions generally for outdoor tests. Implemented system was able to generate Effective Force graph for 3D plot symmetry analysis, torque and power symmetry for specialist's analysis. PMID:26737085

  12. Design considerations for a /hacek C/erenkov ring imaging detector at the tau-charm factory

    SciTech Connect

    Ratcliff, B.N.

    1989-08-01

    A schematic design of a /hacek C/erenkov ring imaging detector for use at a /tau/-charm factory is described. The performance of this device and its implications for the other parts of the spectrometer are discussed. 11 refs., 4 figs.

  13. Translational Research in South Africa: Evaluating Implementation Quality Using a Factorial Design

    PubMed Central

    Smith, Edward A.; Collins, Linda M.; Graham, John W.; Lai, Mary; Wegner, Lisa; Vergnani, Tania; Matthews, Catherine; Jacobs, Joachim

    2012-01-01

    Background HealthWise South Africa: Life Skills for Adolescents (HW) is an evidence-based substance use and sexual risk prevention program that emphasizes the positive use of leisure time. Since 2000, this program has evolved from pilot testing through an efficacy trial involving over 7,000 youth in the Cape Town area. Beginning in 2011, through 2015, we are undertaking a new study that expands HW to all schools in the Metro South Education District. Objective This paper describes a research study designed in partnership with our South African collaborators that examines three factors hypothesized to affect the quality and fidelity of HW implementation: enhanced teacher training; teacher support, structure and supervision; and enhanced school environment. Methods Teachers and students from 56 schools in the Cape Town area will participate in this study. Teacher observations are the primary means of collecting data on factors affecting implementation quality. These factors address the practical concerns of teachers and schools related to likelihood of use and cost-effectiveness, and are hypothesized to be “active ingredients” related to high-quality program implementation in real-world settings. An innovative factorial experimental design was chosen to enable estimation of the individual effect of each of the three factors. Results Because this paper describes the conceptualization of our study, results are not yet available. Conclusions The results of this study may have both substantive and methodological implications for advancing Type 2 translational research. PMID:22707870

  14. Solid Lipid Nanoparticles of Atovaquone Based on 24 Full-Factorial Design

    PubMed Central

    Mohtar, Noratiqah; A. K. Khan, Nurzalina; Darwis, Yusrida

    2015-01-01

    Solid lipid nanoparticles of atovaquone (ATQ-SLN) were prepared by high shear homogenization method using tripalmitin, trilaurin, and Compritol 888 ATO as the lipid matrices and Phospholipon 90H, Tween 80, and poloxamer 188 as the surfactants. Optimization of the formulations was conducted using 6 sets of 24 full-factorial design based on four independent variables that were the number of homogenizing cycles, concentration of the lipid, concentration of the co-surfactant, and concentration of the main surfactant. The dependent variables were particle size and polydispersity index (PdI). The homogenizing cycles showed a negative influence on the dependent variables which reduced both the particle size and the PdI value. Moreover, a combination of certain percentages of the main surfactant and co-surfactant also showed a negative influence that reduced both the particle size and PdI value. Selected formulations from each design were further characterized for the entrapment efficiency and yield. The optimised formulation of ATQ-SLN consisted of trilaurin, Phospholipon 90H and Tween 80 with a particle size of 89.4 ± 0.2 nm and entrapment efficiency of 83.0 ± 1.7%. The in-vitro release evaluation of the formulation showed a complete and immediate release of ATQ from the SLN that could be a solution to improve the poor aqueous solubility and hence poor bioavailability of the drug. PMID:26664366

  15. Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles.

    PubMed

    Kumar, Lalit; Sreenivasa Reddy, M; Managuli, Renuka S; Pai K, Girish

    2015-10-01

    High performance liquid chromatographic method was optimized, developed and validated as per the ICH guidelines. In this study the 20 mM ammonium formate and acetonitrile in the 57:43 ratio were used as mobile phase for the analysis of valsartan. Full factorial design was used to optimize the effect of variable factors. The responses were peak area, tailing factor and number of theoretical plates. The quadratic effect of flow rate and wavelength individually as well as in interaction were most significant (p < 0.0001 and p < 0.0086, respectively) on peak area; the quadratic effect of pH of buffer was also most significant effect (p < 0.0001) on tailing factor (5%) whereas the quadratic effect of flow rate and wavelength individually was significant (p = 0.0006 and p = 0.0265, respectively) on the number of theoretical plates. The high-performance liquid chromatographic separation was performed at the flow rate 1.0 min/mL, UV detector wavelength 250 nm and pH of the buffer 3.0 as optimized parameters using design of experiments. The retention time values of valsartan were found to be 10.177 min. Percent recovery in terms of accuracy for the prepared valsartan nanoparticles was found in the range of 98.57-100.27%. PMID:26594122

  16. Formulation and evaluation of sustained release bioadhesive tablets of ofloxacin using 32 factorial design

    PubMed Central

    Gangurde, Hemant H; Chordiya, Mayur A; Tamizharasi, S; Senthilkumaran, K; Sivakumar, T

    2011-01-01

    Background: Oral sustained release gastroretentive dosage forms offer many advantages for drugs having absorption from upper gastrointestinal tract and improve the bioavailability of medications that are characterized by narrow absorption window. The aim of current study was to design sustained release bioadhesive gastroretentive dosage form of ofloxacin. Materials and Methods: A 32 full factorial design was employed to systematically study the drug release profile and bioadhesive strength. Carbopol 934P and HPMC K100M were selected as the independent variables. Compatibility between drug and polymer was tested by fourier transform infrared (FTIR) and X-ray diffraction (XRD) techniques. Tablets were prepared by direct compression and were evaluated for tablet characteristics, swelling study, adhesion strength, percent drug released, radiographic imaging study and stability study. The optimized formulation was then compared with marketed formulation (Oflin OD®). Results: Tablets prepared showed good tablet characteristics, optimum swelling property, and good adhesion strength with high detachment force. Most of the formulations including the optimized formulation followed Higuchi kinetics and the drug release mechanism was found to be anomalous. Radiographic image proved that tablet remains intact in its structural integrity and shape in stomach up to 24 h. The short-term accelerated stability testing was carried out for the optimized formulation, and results revealed that drug content, in-vitro dissolution and all other parameters were within acceptable limits. Conclusion: Thus, the prepared bioadhesive gastroretentive ofloxacin tablet may prove to be a potential candidate which increases the bioavailability of ofloxacin for any intragastric condition. PMID:23071937

  17. Assessment of the recycling potential of fresh concrete waste using a factorial design of experiments.

    PubMed

    Correia, S L; Souza, F L; Dienstmann, G; Segadães, A M

    2009-11-01

    Recycling of industrial wastes and by-products can help reduce the cost of waste treatment prior to disposal and eventually preserve natural resources and energy. To assess the recycling potential of a given waste, it is important to select a tool capable of giving clear indications either way, with the least time and work consumption, as is the case of modelling the system properties using the results obtained from statistical design of experiments. In this work, the aggregate reclaimed from the mud that results from washout and cleaning operations of fresh concrete mixer trucks (fresh concrete waste, FCW) was recycled into new concrete with various water/cement ratios, as replacement of natural fine aggregates. A 3(2) factorial design of experiments was used to model fresh concrete consistency index and hardened concrete water absorption and 7- and 28-day compressive strength, as functions of FCW content and water/cement ratio, and the resulting regression equations and contour plots were validated with confirmation experiments. The results showed that the fresh concrete workability worsened with the increase in FCW content but the water absorption (5-10 wt.%), 7-day compressive strength (26-36 MPa) and 28-day compressive strength (32-44 MPa) remained within the specified ranges, thus demonstrating that the aggregate reclaimed from FCW can be recycled into new concrete mixtures with lower natural aggregate content. PMID:19596189

  18. Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles

    PubMed Central

    Kumar, Lalit; Sreenivasa Reddy, M.; Managuli, Renuka S.; Pai K., Girish

    2015-01-01

    High performance liquid chromatographic method was optimized, developed and validated as per the ICH guidelines. In this study the 20 mM ammonium formate and acetonitrile in the 57:43 ratio were used as mobile phase for the analysis of valsartan. Full factorial design was used to optimize the effect of variable factors. The responses were peak area, tailing factor and number of theoretical plates. The quadratic effect of flow rate and wavelength individually as well as in interaction were most significant (p < 0.0001 and p < 0.0086, respectively) on peak area; the quadratic effect of pH of buffer was also most significant effect (p < 0.0001) on tailing factor (5%) whereas the quadratic effect of flow rate and wavelength individually was significant (p = 0.0006 and p = 0.0265, respectively) on the number of theoretical plates. The high-performance liquid chromatographic separation was performed at the flow rate 1.0 min/mL, UV detector wavelength 250 nm and pH of the buffer 3.0 as optimized parameters using design of experiments. The retention time values of valsartan were found to be 10.177 min. Percent recovery in terms of accuracy for the prepared valsartan nanoparticles was found in the range of 98.57–100.27%. PMID:26594122

  19. Formulation optimization of etoposide loaded PLGA nanoparticles by double factorial design and their evaluation.

    PubMed

    Yadav, Khushwant S; Sawant, Krutika K

    2010-01-01

    Etoposide is one of the most commonly used drugs in chemotherapy of acute lymphocytic leukemia and acute myelogenous leukaemia. Etoposide has variable oral bioavailability ranging from 24-74% and has terminal half life of 1.5 hours by intravenous route. The conventional parenteral therapy causes inconvenience and pain to the patients as it has to be given through a continuous IV infusion over 24-34 h. The present investigation was aimed at developing etoposide loaded biodegradable nanoparticles which would be a sustained release formulation and replace the conventional therapy of continuous intravenous administration. Nanoparticles were prepared by emulsion solvent evaporation method using high pressure homogenization. The process parameters like homogenization cycles (four) and homogenization pressure (10000 psi) were first optimized using a 3(2) factorial design based on response Y1(mean particle size of 98+/-1nm). Then a 32 factorial design was carried out to study the effect of two independent variables, ratio of drug and polymer (X1) and surfactant concentration (X2) on the two responses to obtain their optimized values, percentage entrapment efficiency (Y2, 83.12+/-8.3%) and mean particle size (Y3, 105+/-5.4 nm) for Etoposide loaded PLGA Nanoparticles. Contour plots and response surface plots showed visual representation of relationship between the experimental responses and the set of input variables. The adequacy of the regression model was verified by a check point analysis. The zeta potential values ranged between -23.0 to -34.2 mV, indicating stability. Sucrose was used as cryoprotectant during lyophilization. DSC and XRD studies indicated that etoposide was present in the amorphous phase and may have been homogeneously dispersed in the PLGA matrix. The electron micrographs showed spherical, discrete and homogenous particles. Drug release study showed that etoposide loaded PLGA nanoparticles sustained release up to 72h. The release from the nanoparticles

  20. A quality by design approach to optimization of emulsions for electrospinning using factorial and D-optimal designs.

    PubMed

    Badawi, Mariam A; El-Khordagui, Labiba K

    2014-07-16

    Emulsion electrospinning is a multifactorial process used to generate nanofibers loaded with hydrophilic drugs or macromolecules for diverse biomedical applications. Emulsion electrospinnability is greatly impacted by the emulsion pharmaceutical attributes. The aim of this study was to apply a quality by design (QbD) approach based on design of experiments as a risk-based proactive approach to achieve predictable critical quality attributes (CQAs) in w/o emulsions for electrospinning. Polycaprolactone (PCL)-thickened w/o emulsions containing doxycycline HCl were formulated using a Span 60/sodium lauryl sulfate (SLS) emulsifier blend. The identified emulsion CQAs (stability, viscosity and conductivity) were linked with electrospinnability using a 3(3) factorial design to optimize emulsion composition for phase stability and a D-optimal design to optimize stable emulsions for viscosity and conductivity after shifting the design space. The three independent variables, emulsifier blend composition, organic:aqueous phase ratio and polymer concentration, had a significant effect (p<0.05) on emulsion CQAs, the emulsifier blend composition exerting prominent main and interaction effects. Scanning electron microscopy (SEM) of emulsion-electrospun NFs and desirability functions allowed modeling of emulsion CQAs to predict electrospinnable formulations. A QbD approach successfully built quality in electrospinnable emulsions, allowing development of hydrophilic drug-loaded nanofibers with desired morphological characteristics. PMID:24704153

  1. Decision making preferences in the medical encounter – a factorial survey design

    PubMed Central

    Müller-Engelmann, Meike; Krones, Tanja; Keller, Heidi; Donner-Banzhoff, Norbert

    2008-01-01

    Background Up to now it has not been systematically investigated in which kind of clinical situations a consultation style based on shared decision making (SDM) is preferred by patients and physicians. We suggest the factorial survey design to address this problem. This method, which so far has hardly been used in health service research, allows to vary relevant factors describing clinical situations as variables systematically in an experimental random design and to investigate their importance in large samples. Methods/Design To identify situational factors for the survey we first performed a literature search which was followed by a qualitative interview study with patients, physicians and health care experts. As a result, 7 factors (e.g. "Reason for consultation" and "Number of therapeutic options") with 2 to 3 levels (e.g. "One therapeutic option" and "More than one therapeutic option") will be included in the study. For the survey the factor levels will be randomly combined to short stories describing different treatment situations. A randomized sample of all possible short stories will be given to at least 300 subjects (100 GPs, 100 patients and 100 members of self-help groups) who will be asked to rate how the decision should be made. Main outcome measure is the preference for participation in the decision making process in the given clinical situation. Data analysis will estimate the effects of the factors on the rating and also examine differences between groups. Discussion The results will reveal the effects of situational variations on participation preferences. Thus, our findings will contribute to the understanding of normative values in the medical decision making process and will improve future implementation of SDM and decision aids. PMID:19091091

  2. Exposure to movie smoking, antismoking ads and smoking intensity: an experimental study with a factorial design

    PubMed Central

    Harakeh, Zeena; Engels, Rutger C M E; Vohs, Kathleen; van Baaren, Rick B; Sargent, James

    2013-01-01

    Background This study examines whether smoking portrayal in movies or antismoking advertisements affect smoking intensity among young adults. Methods We conducted an experimental study in which 84 smokers were randomly assigned using a two (no-smoking versus smoking portrayal in the movie) by three (two prosocial ads, two antismoking ads or one of each) factorial design. Participants viewed a 60-minute movie with two commercial breaks and afterwards completed a questionnaire. Smoking during the session was allowed and observed. Results Exposure to the movie with smoking had no effect on smoking intensity. Those who viewed two antismoking ads had significantly lower smoking intensity compared with those who viewed two prosocial ads. There was no interaction between movie smoking and antismoking ads. Baseline CO (carbon monoxide) level had the largest effect on smoking intensity. Conclusion These findings provide further evidence to support antismoking ads placed with movies because of their possible effect on young adult smoking behaviour. However, caution is warranted, because nicotine dependence appears to be the primary predictor of smoking intensity among young adult smokers in this study. PMID:20008155

  3. Optimization of HPMC and carbopol concentrations in non-effervescent floating tablet through factorial design.

    PubMed

    Acharya, Sujata; Patra, Sradhanjali; Pani, Nihar Ranjan

    2014-02-15

    This study was to optimize HPMC K4M and carbopol 934 concentration in the development of non-effervescent floating tablets (NEFTs) of glipizide as model drug using 3(2) factorial design. The time required for releasing drug of 50% and 80% and similarity factor were the target responses. HPMC K4M and carbopol 934 concentrations were the variables. The response surface methodology and optimized polynomial equations were used to select the optimal formulation with desired responses. The excipients used in tablets were compatible with glipizide as per the results of isothermal stress testing and DSC study. The drug release of entire NEFTs followed zero order kinetics and non-Fickian diffusion mechanism. Validation of the optimization technique demonstrated the reliability of the model. The optimized formulation containing 124.33 mg HPMC K4M and 25.76 mg carbopol 934 was prepared according to the software determined levels. The stability study of the optimized formulation proved the integrity of the developed formulation. PMID:24507292

  4. Factorial design applied to the optimization of lipid composition of topical antiherpetic nanoemulsions containing isoflavone genistein

    PubMed Central

    Argenta, Débora Fretes; de Mattos, Cristiane Bastos; Misturini, Fabíola Dallarosa; Koester, Leticia Scherer; Bassani, Valquiria Linck; Simões, Cláudia Maria Oliveira; Teixeira, Helder Ferreira

    2014-01-01

    The aim of this study was to optimize topical nanoemulsions containing genistein, by means of a 23 full factorial design based on physicochemical properties and skin retention. The experimental arrangement was constructed using oil type (isopropyl myristate or castor oil), phospholipid type (distearoylphosphatidylcholine [DSPC] or dioleylphosphaditylcholine [DOPC]), and ionic cosurfactant type (oleic acid or oleylamine) as independent variables. The analysis of variance showed effect of third order for particle size, polydispersity index, and skin retention of genistein. Nanoemulsions composed of isopropyl myristate/DOPC/oleylamine showed the smallest diameter and highest genistein amount in porcine ear skin whereas the formulation composed of isopropyl myristate/DSPC/oleylamine exhibited the lowest polydispersity index. Thus, these two formulations were selected for further studies. The formulations presented positive ζ potential values (>25 mV) and genistein content close to 100% (at 1 mg/mL). The incorporation of genistein in nanoemulsions significantly increased the retention of this isoflavone in epidermis and dermis, especially when the formulation composed by isopropyl myristate/DOPC/oleylamine was used. These results were supported by confocal images. Such formulations exhibited antiherpetic activity in vitro against herpes simplex virus 1 (strain KOS) and herpes simplex virus 22 (strain 333). Taken together, the results show that the genistein-loaded nanoemulsions developed in this study are promising options in herpes treatment. PMID:25336951

  5. Overcoming obstacles in the implementation of factorial design for assay optimization.

    PubMed

    Shaw, Robert; Fitzek, Martina; Mouchet, Elizabeth; Walker, Graeme; Jarvis, Philip

    2015-03-01

    Factorial experimental design (FED) is a powerful approach for efficient optimization of robust in vitro assays-it enables cost and time savings while also improving the quality of assays. Although it is a well-known technique, there can be considerable barriers to overcome to fully exploit it within an industrial or academic organization. The article describes a tactical roll out of FED to a scientist group through: training which demystifies the technical components and concentrates on principles and examples; a user-friendly Excel-based tool for deconvoluting plate data; output which focuses on graphical display of data over complex statistics. The use of FED historically has generally been in conjunction with automated technology; however we have demonstrated a much broader impact of FED on the assay development process. The standardized approaches we have rolled out have helped to integrate FED as a fundamental part of assay development best practice because it can be used independently of the automation and vendor-supplied software. The techniques are applicable to different types of assay, both enzyme and cell, and can be used flexibly in manual and automated processes. This article describes the application of FED for a cellular assay. The challenges of selling FED concepts and rolling out to a wide bioscience community together with recommendations for good working practices and effective implementation are discussed. The accessible nature of these approaches means FED can be used by industrial as well as academic users. PMID:25710279

  6. Development and optimization of novel controlled-release pioglitazone provesicular powders using 3² factorial design.

    PubMed

    Shukr, Marwa H; Eltablawy, Nadia A

    2015-02-01

    This work aimed at studying a novel controlled drug delivery proniosomal formulation of pioglitazone for treatment of diabetes type-2. The effects of independent variables like type of surfactant and ratio of surfactants/cholesterol were studied using 3(2) factorial design. The provesicular powders were characterized regarding their encapsulation efficiency, vesicle size, morphology, and in vitro drug release. The revealed optimal provesicular powder was exposed to stability testing and in vivo performance evaluation. Results showed that F6 was selected as the optimal formulation, and its in vivo hypoglycemic effect on normal healthy and STZ-induced diabetic albino rats was investigated. F6 proniosomal formulation exhibited a significantly higher % decrease (56.18 % for STZ-induced diabetic albino rats) of blood glucose level (BGL) than Actos® (32. % for STZ-induced diabetic albino rats). Higher % decrease of BGL with longer t max and lower AUC0-24 confirms the development of a successful proniosomal pioglitazone formulation. PMID:25787339

  7. Compatible validated spectrofluorimetric and spectrophotometric methods for determination of vildagliptin and saxagliptin by factorial design experiments.

    PubMed

    Abdel-Aziz, Omar; Ayad, Miriam F; Tadros, Mariam M

    2015-04-01

    Simple, selective and reproducible spectrofluorimetric and spectrophotometric methods have been developed for the determination of vildagliptin and saxagliptin in bulk and their pharmaceutical dosage forms. The first proposed spectrofluorimetric method is based on the dansylation reaction of the amino group of vildagliptin with dansyl chloride to form a highly fluorescent product. The formed product was measured spectrofluorimetrically at 455 nm after excitation at 345 nm. Beer's law was obeyed in a concentration range of 100-600 μg ml(-1). The second proposed spectrophotometric method is based on the charge transfer complex of saxagliptin with tetrachloro-1,4-benzoquinone (p-chloranil). The formed charge transfer complex was measured spectrophotometrically at 530 nm. Beer's law was obeyed in a concentration range of 100-850 μg ml(-1). The third proposed spectrophotometric method is based on the condensation reaction of the primary amino group of saxagliptin with formaldehyde and acetyl acetone to form a yellow colored product known as Hantzsch reaction, measured at 342.5 nm. Beer's law was obeyed in a concentration range of 50-300 μg ml(-1). All the variables were studied to optimize the reactions' conditions using factorial design. The developed methods were validated and proved to be specific and accurate for quality control of vildagliptin and saxagliptin in their pharmaceutical dosage forms. PMID:25613694

  8. Compatible validated spectrofluorimetric and spectrophotometric methods for determination of vildagliptin and saxagliptin by factorial design experiments

    NASA Astrophysics Data System (ADS)

    Abdel-Aziz, Omar; Ayad, Miriam F.; Tadros, Mariam M.

    2015-04-01

    Simple, selective and reproducible spectrofluorimetric and spectrophotometric methods have been developed for the determination of vildagliptin and saxagliptin in bulk and their pharmaceutical dosage forms. The first proposed spectrofluorimetric method is based on the dansylation reaction of the amino group of vildagliptin with dansyl chloride to form a highly fluorescent product. The formed product was measured spectrofluorimetrically at 455 nm after excitation at 345 nm. Beer's law was obeyed in a concentration range of 100-600 μg ml-1. The second proposed spectrophotometric method is based on the charge transfer complex of saxagliptin with tetrachloro-1,4-benzoquinone (p-chloranil). The formed charge transfer complex was measured spectrophotometrically at 530 nm. Beer's law was obeyed in a concentration range of 100-850 μg ml-1. The third proposed spectrophotometric method is based on the condensation reaction of the primary amino group of saxagliptin with formaldehyde and acetyl acetone to form a yellow colored product known as Hantzsch reaction, measured at 342.5 nm. Beer's law was obeyed in a concentration range of 50-300 μg ml-1. All the variables were studied to optimize the reactions' conditions using factorial design. The developed methods were validated and proved to be specific and accurate for quality control of vildagliptin and saxagliptin in their pharmaceutical dosage forms.

  9. A factorial design study on the physical stability of 3-in-1 admixtures.

    PubMed

    Li, L C; Sampogna, T P

    1993-11-01

    The effects of dextrose concentration, the compounding method, and storage conditions, on the physical stability of 3-in-1 admixtures were investigated using a 2n factorial design. The main effect of these three variables on the weight percent of oil globules larger than 5 microns (by HIAC) was found to be statistically significant. However, the effects of interaction amongst these variables, except the two-way interaction between dextrose concentration and storage conditions, were found to be statistically insignificant. A higher dextrose concentration was shown to enhance the physical stability of the admixtures, while low-temperature storage (three days at 5 degrees C) was more favourable for maintaining the physical stability of the admixtures with a low dextrose concentration. Although sequential pumping produced admixtures with a slightly lower final weight percentage of larger oil globules (> 5 microns), the method of compounding has the least impact on the physical stability of the admixtures in comparison with the other two variables evaluated in this study. The storage of the admixtures at room temperature for one day was shown to have a greater adverse effect on admixtures with a low dextrose concentration. PMID:7908042

  10. Biosorption of Ni(II) by Fig Male: Optimization and Modeling Using a Full Factorial Design.

    PubMed

    Madjene, F; Chergui, A; Trari, M

    2016-06-01

    The fig male (FM) is successfully used as biosorbent for Ni(2+) removal. The maximum removal efficiency (96.6%) is obtained at pH ~ 5 for a concentration of 1.70 mmol L(-1) and catalyst dose of 5 g L(-1) in less than 10 minutes. The Ni(2+) uptake follows a pseudo-second-order kinetic, the rate constants increase with increasing temperature, and an activation energy of 55.48 kJ mol(-1) is found. The thermodynamic parameters indicate a spontaneous endothermic bisorption. The isotherm data are fitted by the Langmuir and Dubinin-Radushkevich models. The former indicates a maximum Ni(2+) uptake of 0.459 mmol g(-1), which is higher than that of most biosorbents investigated to date. The FTIR spectra reveal the biosorption mechanism between Ni(2+) and FM functional groups. An empirical modeling is performed by using a 2(3) full factorial design, and a regression equation for Ni(2+) biosorption is determined. The biosorbent mass and pH are the most significant parameters affecting the Ni(2+) biosorption. PMID:27225783

  11. Design of a 10**36 CM-2 S-1 Super-B Factory

    SciTech Connect

    Biagini, M.E.; Boni, R.; Boscolo, M.; Demma, T.; Drago, A.; Guiducci, S.; Raimondi, P.; Tomassini, S.; Zobov, M.; Bertsche, Kirk J.; Novokhatski, A.; Seeman, J.; Sullivan, M.; Wienands, U.; Wittmer, W.; Bettoni, S.; Paoloni, E.; Marchiori, G.; Bogomyagkov, A.; Koop, I.; Levichev, E.; /Novosibirsk, IYF

    2011-10-24

    Parameters have been studied for a high luminosity e{sup +}e{sup -} collider operating at the Upsilon 4S that would deliver a luminosity of 1 to 4 x 10{sup 36}/cm{sup 2}/s. This collider, called a Super-B Factory, would use a combination of linear collider and storage ring techniques. In this scheme an electron beam and a positron beam are stored in low-emittance damping rings similar to those designed for a Linear Collider (LC) or the next generation light source. A LC style interaction region is included in the ring to produce sub-millimeter vertical beta functions at the collision point. A large crossing angle (+/- 24 mrad) is used at the collision point to allow beam separation. A crab-waist scheme is used to reduce the hourglass effect and restore peak luminosity. Beam currents of 1.8 A at 4 x 7 GeV in 1251 bunches can produce a luminosity of 10{sup 36}/cm{sup 2}/s with upgrade possibilities. Such a collider would produce an integrated luminosity of about 10,000 fb{sup -1} (10 ab{sup -1}) in a running year (10{sup 7} sec) at the {gamma}(4S) resonance. Further possibilities include having longitudinally polarized e- at the IR and operating at the J/Psi and Psi beam energies.

  12. Full factorial design optimization of anti-inflammatory drug release by PCL-PEG-PCL microspheres.

    PubMed

    Azouz, L'Hachemi; Dahmoune, Farid; Rezgui, Farouk; G'Sell, Christian

    2016-01-01

    A biodegradable triblock poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) copolymer was successfully synthesized by ring-opening polymerization of ε-caprolactone, and was characterized by intrinsic viscosimetry, (1)H nuclear magnetic resonance, infrared spectroscopy and X-ray diffraction. Copolymer microparticles loaded with ibuprofen were prepared by an oil-in-water (o/w) emulsion solvent evaporation process. They were carefully weighted and characterized through their zeta potential. In this work, 4 selected process parameters (shaking speed X1, time of contact X2, poly(vinyl alcohol) concentration X3, and ibuprofen concentration X4) were adjusted at 2 different values. For each of the 16 experimental conditions, repeated twice, the drug encapsulation efficiency of the microspheres was determined, according to the following definition: EE (X1, X2, X3, X4)=mass of encapsulated ibuprofen/total weight of ibuprofen. A "full factorial design method" was applied to analyze the results statistically according to a polynomial fit and to determine the optimal conditions for the microencapsulation of the ibuprofen through an accurate statistical protocol. The microparticles obtained exhibit a spherical shape as shown by electron microscopy. PMID:26478328

  13. Sliding Wear Response of Beryl Reinforced Aluminum Composite - A Factorial Design Approach

    NASA Astrophysics Data System (ADS)

    Bharat, V.; Durga Prasad, B.; Prabhakar, M. Bhovi; Venkateswarlu, K.

    2016-02-01

    Al-Beryl MMCs were successfully fabricated using powder metallurgy route. Processing conditions such as beryl content and particle size were varied and its influence on dry sliding wear response was studied. Effect of test parameters like applied load and sliding distance on wear performance of Al-Beryl MMCs were discussed detail. Sliding wear tests were conducted using a pin on disc machine based on the 24 (4 factors at 2 levels) factorial design. Analysis of variance (ANOVA) was performed to obtain the contribution of control parameters on wear rate. The present study shows that wear resistance of Al-beryl MMCs not only depends on the beryl content but also influenced by normal load, sliding distance and particle size. The results show that most significant variables affecting wear rate of Al - beryl MMCs are size of the beryl particles (22%), beryl content (19.60%), sliding distance (18.47%), and normal load (10.30%). The interaction effects of these parameters are less significant in influencing wear rate compared to the individual parameters. The correlation between sliding wear and its parameters was obtained by multiple regression analysis. Regression model developed in the present study can be successfully implemented to predict the wear response of Al-Beryl MMCs.

  14. Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design

    PubMed Central

    Gajra, Balaram; Pandya, Saurabh S.; Singh, Sanjay; Rabari, Haribhai A.

    2014-01-01

    The mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral Candidiasis. The mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol) by freeze/thaw crosslinking technique. 32 full factorial design was employed to optimize the formulation. Number of freeze/thaw cycles (4, 6, and 8 cycles) and the concentration of the poly(vinyl alcohol) (10, 15, and 20%) were used as the independent variables whereas time required for 50% drug release, cumulative percent of drug release at 8th hour, and “k” of zero order equation were used as the dependent variables. The films were evaluated for mucoadhesive strength, in vitro residence time, swelling study, in vitro drug release, and effectiveness against Candida albicans. The concentration of poly(vinyl alcohol) and the number of freeze/thaw cycles both decrease the drug release rate. Mucoadhesive hydrogel film with 15% poly(vinyl alcohol) and 7 freeze/thaw cycles was optimized. The optimized batch exhibited the sustained release of drug and the antifungal studies revealed that the drug released from the film could inhibit the growth of Candida albicans for 12 hours. PMID:25006462

  15. Pediatric Diabetic Ketoacidosis, Fluid Therapy and Cerebral Injury: The Design of a Factorial Randomized Controlled Trial

    PubMed Central

    Glaser, Nicole S.; Ghetti, Simona; Casper, T. Charles; Dean, J. Michael; Kuppermann, Nathan

    2013-01-01

    Treatment protocols for pediatric diabetic ketoacidosis (DKA) vary considerably among centers in the United States and worldwide. The optimal protocol for intravenous fluid administration is an area of particular controversy, mainly in regard to possible associations between rates of intravenous fluid infusion and the development of cerebral edema, the most common and most feared complication of DKA in children. Theoretical concerns about associations between osmotic fluid shifts and cerebral edema have prompted recommendations for conservative fluid infusion during DKA. However, recent data suggest that cerebral hypoperfusion may play a role in cerebral injury associated with DKA. Currently there are no existing data from prospective clinical trials to determine the optimal fluid treatment protocol for pediatric DKA. The Pediatric Emergency Care Applied Research Network FLUID (Fluid Therapies Under Investigation in DKA) Study is the first prospective randomized trial to evaluate fluid regimens for pediatric DKA. This 13-center nationwide factorial-design study will evaluate the effects of rehydration rate and fluid sodium content on neurological status during DKA treatment, the frequency of clinically-overt CE, and long-term neurocognitive outcomes following DKA. PMID:23490311

  16. Design of the Vacuum System for the High Energy Ring of an Asymmetric B-Factory Based on PEP

    SciTech Connect

    Barletta, W.

    2005-04-08

    The multi-ampere currents required for high luminosity operation of an asymmetric B factory leads to extremely stressing requirements on a vacuum system suitable for maintaining long beam-gas lifetimes and acceptable background levels in the detector. They present the design for a Cu alloy vacuum chamber and its associated pumping system for the 9 Gev electron storage ring of the proposed B factory based on PEP. The excellent thermal and photo-desorption properties of Cu allows handling the high photon flux in a conventional, single chamber design with distributed ion pumps. The x-ray opacity of the Cu is sufficiently high that no additional lead shielding is necessary to protect the dipoles from the intense synchrotron radiation generated by the beam. The design allows chamber commissioning in < 500 hr of operation.

  17. Degradation characteristics of metoprolol during UV/chlorination reaction and a factorial design optimization.

    PubMed

    Nam, Seung-Woo; Yoon, Yeomin; Choi, Dae-Jin; Zoh, Kyung-Duk

    2015-03-21

    Metoprolol (MTP), a hypertension depressor, has been increasingly detected even after conventional water treatment processes. In this study, the removal of MTP was compared using chlorination (Cl2), UV-C photolysis, and UV/chlorination (Cl2/UV) reactions. The results showed that the UV/chlorination reaction was most effective for MTP removal. MTP removal during UV/chlorination reaction was optimized under various conditions of UV intensity (1.1-4.4 mW/cm(2)), chlorine dose (1-5 mg/L as Cl2), pH (2-9), and dissolved organic matter (DOM, 1-4 mgC/L) using a two-level factorial design with 16 experimental combinations of the four factors. Among the factors examined, DOM scavenging by OH radicals was the most dominant in terms of MTP removal during UV/chlorination reaction. The established model fit well with the experimental results using to various water samples including surface waters, filtered and tap water samples. The optimized conditions (UV intensity=4.4 mW/cm(2), [Cl2]=5 mg/L, pH 7, and [DOM]=0.8-1.1 mgC/L) of the model removed more than 78.9% of MTP for filtered water samples during UV/chlorination reaction. Using LC-MS/MS, five byproducts of MTP (molecular weight: 171, 211, 309, 313, and 341, respectively) were identified during UV/chlorination reaction. Based on this information, the MTP transformation mechanism during UV/chlorination was suggested. Our results imply that applying UV/chlorination process after filtration stage in the water treatment plant (WTP) would be the most appropriate for effective removal of MTP. PMID:25540942

  18. Formulation and Optimization of Clotrimazole-Loaded Proniosomal Gel Using 32 Factorial Design

    PubMed Central

    Thomas, Litha; Viswanad, Vidya

    2012-01-01

    The main aim of the study was to develop and statistically optimize the proniosomal gel for enhanced transdermal delivery using 32 factorial designs to investigate the influence of both non-ionic surfactant and cholesterol to maximize the entrapment efficiency and flux. The concentration of non-ionic surfactant and cholesterol were taken as independent variables, while entrapment efficiency and flux were taken as dependent variables. The study showed that the entrapment efficiency depends on both cholesterol and surfactant, whereas permeation flux depends only on the surfactant. Proniosomal gel showed a significantly enhanced drug permeation through the skin, with an enhancement ratio 3.81±1.85 when compared to the drug solution. Comparative evaluation of permeation studies and the in vitro release study of optimized proniosomal gel (F5) with that of marketed gel and carbopol gel showed that the penetration of the optimized formulation was enhanced 1.75 times in comparison with that of the marketed formulation, and the release was in a controlled manner. Similarly, the anticandidial activity showed a significantly higher activity (p<0.05) than the marketed and carbopol gel. This may be due to the enhanced penetration of noisome-containing drug through the fungal cell wall, inhibiting the ergo sterol synthesis, thereby causing the fungal cell death due to the presence of penetration enhancer. The stability study at two different temperatures (30 ± 2°C and 4 ± 2°C) confirmed that the formulations were stable even at the end of 45 days. Hence, proniosomal gel is an efficient carrier for the delivery of clotrimazole, thereby prolonging the action. PMID:23008818

  19. NAMER: A FORTRAN 4 program for use in optimizing designs of two-level factorial experiments given partial prior information

    NASA Technical Reports Server (NTRS)

    Sidik, S. M.

    1972-01-01

    Under certain specified conditions, the Bayes procedure for designing two-level fractional factorial experiments is that which maximizes the expected utility over all possible choices of parameter-estimator matchings, physical-design variable matchings, defining parameter groups, and sequences of telescoping groups. NAMER computes the utility of all possible matchings of physical variables to design variables and parameters to estimators for a specified choice of defining parameter group or groups. The matching yielding the maximum expected utility is indicated, and detailed information is provided about the optimal matchings and utilities. Complete documentation is given; and an example illustrates input, output, and usage.

  20. Midlands Teaching Factory, LTD.

    ERIC Educational Resources Information Center

    Midlands Technical Coll., Columbia, SC.

    In 1987, Midlands Technical College (MTC), in Columbia, South Carolina, initiated a Computer Integrated Manufacturing (CIM) project, the Midlands Teaching Factory, LTD, which integrated various college departments with the goal of manufacturing a high quality, saleable product. The faculty developed a teaching factory model which was designed to…

  1. Factorial design in the spheronization of ibuprofen microparticulates using the rotor disk fluid-bed technology.

    PubMed

    Chukwumezie, Beatrice Nkem; Wojcik, Mark; Malak, Paul; Damico, Frank; Adeyeye, Moji Christianah

    2004-01-01

    The aim of this study was to statistically evaluate the effects of some formulation and process variables in the spheronization of microparticulates of ibuprofen using the rotor disk fluid-bed technology and water as binder. Preliminary studies revealed that presence of surfactant, plate material type, and nature and content of binder influenced the process and quality of the spheronized material. A 2 x 2 x 3 full factorial randomized experiment was designed, demonstrating the influence of these factors on properties such as percent yield, particle size distribution, densities, ibuprofen release, moisture content, etc., as well as their interactions in the experimental response. A response known as the usable fraction was created representing microparticulates of 250 to 850 microm sizes (mesh size 20-60). The reproducibility of the spheronization process was assessed by blocking the experiments with the experiments within the blocks randomly replicated. The main effects included two binder levels (X1), two surfactant levels (X2), and a three-level plate type (X3) in which 2 two-level factors were collapsed into a single three-level factor. The results from the statistical analysis (general linear model, JMP 4) showed that the variables studied had a significant influence on most of the response variables evaluated (p < 0.05), with the binder level proving to be the most significant of the three. There was also significant interaction (p<0.05) between binder level and plate type with the drug content, friability, sphericity, loss on drying (LOD), and usable fraction response variables, and between the binder and the surfactant levels with the drug content, Q20, true density, geometric mean diameter, LOD, and usable fraction responses. High levels of surfactant and binder increased the sphere size, while low levels decreased it. Significant (p < 0.05) interaction was also observed between the plate type and surfactant level with the drug content, geometric mean

  2. e+ e- Factory Developments

    SciTech Connect

    Sullivan, Michael; /SLAC

    2010-08-26

    The impressive performance of current (KEKB) and recent (PEP-II) B-Factory colliders has increased interest in developing even higher luminosity B-factories. Two new designs are being developed (SuperKEKB and SuperB). Both designs plan to deliver a luminosity in the range of 1 x 10{sup 36} cm{sup -2}s{sup -1}, nearly 100 times the present B-factory level. Achieving this high luminosity requires high-current beams and short bunch lengths and/or a new way of colliding the beams. The SuperB design employs a crabbed magnetic waist with a large crossing angle and the SuperKEKB design is looking at crab cavities with high-current beams and/or a travelling focus. I describe the designs being studied to achieve the high luminosity needed for the next generation of B-Factories.

  3. A Non-scaling Fixed Field Alternating Gradient Accelerator for the Final Acceleration Stage of the International Design Study of the Neutrino Factory.

    SciTech Connect

    Berg, J.S.; Aslaninejad, M.; Pasternak, J.; Witte, H.; Bliss, N. Cordwell M.; Jones, T.; Muir, A., Kelliher, D.; Machida, S.

    2011-09-04

    The International Design Study of the Neutrino Factory (IDS-NF) has recently completed its Interim Design Report (IDR), which presents our current baseline design of the neutrino factory. To increase the efficiency and reduce the cost of acceleration, the IDR design uses a linear non-scaling fixed field alternating gradient accelerator (FFAG) for its final acceleration stage. We present the current lattice design of that FFAG, including the main ring plus its injection and extraction systems. We describe parameters for the main ring magnets, kickers, and septa, as well as the power supplies for the kickers. We present a first pass at an engineering layout for the ring and its subsystems.

  4. In vitro controlled release of colon targeted mesalamine from compritol ATO 888 based matrix tablets using factorial design

    PubMed Central

    Patel, J.K.; Patel, N.V.; Shah, S.H.

    2009-01-01

    A controlled release matrix formulation for mesalamine was designed and developed to achieve a 24 h release profile. Using compritol 888 ATO (glyceryl behenate) as an inert matrix-forming agent to control the release of mesalamine, formulation granules containing the solid dispersions were investigated. Pectin, a polysaccharide, was used as bacterial dependent polymer for colon targeting. The matrix tablets for these formulations were prepared by direct compression and their in vitro release tests were carried out. A 32 full factorial design was used for optimization by taking the amounts of glyceryl behenate (X1) and pectin (X2) as independent variables and percentage drug released at 2 (Q2), 16 (Q16) and 24 (Q24) h as dependent variables. Drug release from the matrix tablets formulations lasted for over 24 h. Images of the tablet surface and cross-section were characterized by scanning electron microscopy to show the formed pores and channels in the matrices. These may provide the release pathway for the inner embedded drugs. The co-mixing of polysaccharide pectin, into the waxy matrices played a meaningful role in targeting the tablets to colon. The drug release from the novel formulation may be attributed to the diffusion-controlled mechanism. The results of the full factorial design indicated that an optimum amount of compritol ATO 888 and a high amount of pectin favors the colon targeting and controlled release of mesalamine from dosage form. PMID:21589801

  5. An approach to optimize sample preparation for MALDI imaging MS of FFPE sections using fractional factorial design of experiments.

    PubMed

    Oetjen, Janina; Lachmund, Delf; Palmer, Andrew; Alexandrov, Theodore; Becker, Michael; Boskamp, Tobias; Maass, Peter

    2016-09-01

    A standardized workflow for matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI imaging MS) is a prerequisite for the routine use of this promising technology in clinical applications. We present an approach to develop standard operating procedures for MALDI imaging MS sample preparation of formalin-fixed and paraffin-embedded (FFPE) tissue sections based on a novel quantitative measure of dataset quality. To cover many parts of the complex workflow and simultaneously test several parameters, experiments were planned according to a fractional factorial design of experiments (DoE). The effect of ten different experiment parameters was investigated in two distinct DoE sets, each consisting of eight experiments. FFPE rat brain sections were used as standard material because of low biological variance. The mean peak intensity and a recently proposed spatial complexity measure were calculated for a list of 26 predefined peptides obtained by in silico digestion of five different proteins and served as quality criteria. A five-way analysis of variance (ANOVA) was applied on the final scores to retrieve a ranking of experiment parameters with increasing impact on data variance. Graphical abstract MALDI imaging experiments were planned according to fractional factorial design of experiments for the parameters under study. Selected peptide images were evaluated by the chosen quality metric (structure and intensity for a given peak list), and the calculated values were used as an input for the ANOVA. The parameters with the highest impact on the quality were deduced and SOPs recommended. PMID:27485623

  6. Optimization of thiamethoxam adsorption parameters using multi-walled carbon nanotubes by means of fractional factorial design.

    PubMed

    Panić, Sanja; Rakić, Dušan; Guzsvány, Valéria; Kiss, Erne; Boskovic, Goran; Kónya, Zoltán; Kukovecz, Ákos

    2015-12-01

    The aim of this work was to evaluate significant factors affecting the thiamethoxam adsorption efficiency using oxidized multi-walled carbon nanotubes (MWCNTs) as adsorbents. Five factors (initial solution concentration of thiamethoxam in water, temperature, solution pH, MWCNTs weight and contact time) were investigated using 2V(5-1) fractional factorial design. The obtained linear model was statistically tested using analysis of variance (ANOVA) and the analysis of residuals was used to investigate the model validity. It was observed that the factors and their second-order interactions affecting the thiamethoxam removal can be divided into three groups: very important, moderately important and insignificant ones. The initial solution concentration was found to be the most influencing parameter on thiamethoxam adsorption from water. Optimization of the factors levels was carried out by minimizing those parameters which are usually critical in real life: the temperature (energy), contact time (money) and weight of MWCNTs (potential health hazard), in order to maximize the adsorbed amount of the pollutant. The results of maximal adsorbed thiamethoxam amount in both real and optimized experiments indicate that among minimized parameters the adsorption time is one that makes the largest difference. The results of this study indicate that fractional factorial design is very useful tool for screening the higher number of parameters and reducing the number of adsorption experiments. PMID:26151482

  7. Assessment of Biasi and Columbia University CHF correlations with GE 3x3 rod bundle experiment. [PWR; BWR

    SciTech Connect

    Chen, B.C.J.; Chien, T.H.; Sha, W.T.; Kim, J.H.

    1984-01-01

    The critical heat flux (CHF), at which a sudden degradation of heat transfer occurs without corresponding decrease in heat generation, is one of the limiting parameters for safe operation of nuclear reactors. Reactor operation beyond the CHF causes a rapid rise in fuel cladding temperature and thus should be avoided to maintain the fuel element integrity. Reactor power limits are therefore set so that a prescribed safety margin below the CHF is maintained. Two CHF correlations are evaluated for reactor core thermal hydraulic analysis: the Biasi correlation and the Columbia University correlation. The BODYFIT-2PE computer code is used for this assessment. The CHF predicted by the BODYFIT-2PE using the two correlations is compared with GE 3x3 rod bundle CHF experiment.

  8. Thermodynamics-based design of microbial cell factories for anaerobic product formation.

    PubMed

    Cueto-Rojas, Hugo F; van Maris, A J A; Wahl, S Aljoscha; Heijnen, J J

    2015-09-01

    The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates. PMID:26232033

  9. Updated Design of the Italian SuperB Factory Injection System

    SciTech Connect

    Guiducci, S.; Biagini, M.E.; Boni, R.; Preger, M.; Raimondi, P.; Chance, A.; Brossard, J.; Dadoun, O.; Lepercq, P.; Rimbault, C.; Variola, A.; Seeman, J.; /SLAC

    2012-04-26

    The ultra high luminosity B-factory (SuperB) project of INFN requires a high performance and reliable injection system, providing electrons at 4 GeV and positrons at 7 GeV, to fulfill the very tight requirements of the collider. Due to the short beam lifetime, continuous injection of electrons and positrons in both High Energy Ring (HER) and Low Energy Ring (LER) is necessary to keep the average luminosity at a high level. An updated version of the injection system, optimized at higher repetition frequency is presented. This scheme includes a polarized electron gun, a positron production scheme with electron/positron conversion at low energy 0.6 GeV, and a 1 GeV damping ring to reduce the injected emittance of the positron beam.

  10. A Classroom of Polymer Factories.

    ERIC Educational Resources Information Center

    Harris, Mary E.; Van Natta, Sandra

    1998-01-01

    Provides an activity in which students create small classroom factories and investigate several aspects of production including design, engineering, quality control, waste management, packaging, shipment, and communication. (DDR)

  11. Slime Factory.

    ERIC Educational Resources Information Center

    Fowler, Marilyn L.

    1992-01-01

    Describes a classroom activity using slime, a colloid: it behaves like both a solid and liquid. Explains how slime can be produced from guar gum. An activity where students work in teams and become a slime factory is presented. (PR)

  12. The Injection System of the INFN-SuperB Factory Project: Preliminary Design

    SciTech Connect

    Boni, Roberto; Guiducci, Susanna; Preger, Miro; Raimondi, Pantaleo; Chance, Antoine; Dadoun, Olivier; Poirier, Freddy; Variola, Alessandro; Seeman, John; /SLAC

    2012-07-05

    The ultra high luminosity B-factory (SuperB) project of INFN requires a high performance and reliable injection system, providing electrons at 4 GeV and positrons at 7 GeV, to fulfil the very tight requirements of the collider. Due to the short beam lifetime, continuous injection of electron and positron bunches in both LER and HER rings is necessary to maintain an high average luminosity. Polarized electrons are required for experiments and must be delivered by the injection system, due to the beam lifetime shorter than the ring polarization build-up: they will be produced by means of a SLAC-SLC polarized gun. The emittance and the energy spread of the e{sup -}/e{sup +} beams are reduced in a 1 GeV Damping Ring (DR) before injection in the main rings. Two schemes for positron production are under study, one with e{sup -}/e{sup +} conversion at low energy (< 1 Gev) and one with conversion at 6 GeV and a recirculation line to bring the positrons back to the DR. Acceleration through the Linac is provided by a 2856 MHz RF system made of travelling wave (TW), room temperature accelerating structures.

  13. Optimization of extracellular xylanase production by Sclerotinia sclerotiorum S2 using factorial design.

    PubMed

    Ellouze, Olfa; Fattouch, Sami; Mestiri, Faouzi; Aniba, Mohamed Radhouen; Marzouki, Mohamed Nejib

    2008-12-01

    The improvement of xylanase production by Sclerotinia sclerotiorum S2 using a liquid fermentation culture was investigated. The optimized process was divided into three basic steps: (i) evaluating xylanase inducers using different agricultural residues such as wheat bran, oat bran, orange peel and barley bran at 1% final concentration, and also filter paper. Among these, wheat bran showed the maximum activity (2.5 U/ml) at 12 days post-inoculation; (ii) for optimization, we determined the optimal concentration of inducer, the effect of phosphate anion (K2HPO4/KH2PO4) and culture aeration using a rotary shaker at 100 and 180 rpm. The optimal conditions for these three factors were determined in an experimental panel using factorial data, in which a mathematical model (Minitab software) was fitted; (iii) The optimized culture medium containing a high level of wheat bran (3%) without KH2PO4-K2HPO4 and submitted to a high agitation (180 rpm/min) increased the xylanase production from 2.5 U/ml to 4 U/ml (1.6-fold). PMID:19239127

  14. Gastroretentive drug delivery of metformin hydrochloride: formulation and in vitro evaluation using 3(2) full factorial design.

    PubMed

    Boldhane, Sanjay P; Kuchekar, Bhanudas S

    2009-10-01

    Metformin Hydrochloride (MF) is glucose lowering agent that is widely used for management for type II diabetes. MF is reported to be absorbed mainly in upper part of GIT. It is having narrow absorption window and high water solubility, and it would be more beneficial to retain the drug in stomach for prolonged duration so as to achieve maximum absorption and better bioavailability. A conventional oral CR formulation releases most of the drug content at the colon, which requires that the drug will be absorbed from the colon. The present investigation is aimed to develop novel gastroretentive (GR) drug delivery system, which not only release the drug in the absorption window but also provides controlled release drug profile that may result patient compliance and therapeutic success. Floating tablets of MF was prepared using sodium alginate, and sodium carboxymethylcellulose was used as a gelling agent, and release modifiers, respectively. Eudragit NE 30 D was used as sustained release polymer to control the initial burst release. Drug and excipients compatibility studies were monitored by thermal analysis by using differential scanning calorimeter. 32 full factorial design was applied to optimize the formulation. The DSC thermogram of drug, polymer and physical mixtures revealed that there was no known interaction between drug and polymers. The prepared tablets were evaluated for in vitro dissolution, in vitro buoyancy, percentage swelling, percentage erosion and similarity factors with marketed tablets. The optimization study using a 32 full factorial design revealed that the amount of sodium alginate and sodium carboxymethylcellulose had a significant effect on t50, t90, Flag and f2. Thus, by selecting a suitable composition of release rate modifier and gel forming agent, Gastro retentive system can be developed with the desired dissolution profile. This study indicated that the MF GR tablets prepared using sodium alginate and sodium carboxymethylcellulose can

  15. Evaluation the nonlinear response function of a 3 x 3 in NaI scintillation detector for PGNAA applications.

    PubMed

    Miri Hakimabad, Hashem; Panjeh, Hamed; Vejdani-Noghreiyan, Alireza

    2007-08-01

    Response functions of the 3 x 3 in NaI detector, which is mainly used in PGNAA applications, have been calculated by using MCNP-4C code. Calculated results are compared with measured data by using standard gamma-ray sources and prompt gamma-rays from pure element samples to check their accuracy. Prompt gamma-rays from pure element samples were used for this determination in the range from 1.942 to 10.829 MeV by use of (241)Am-Be neutron source and gamma-rays from radioisotope sources were used in the range from 0.081 to 4.438 MeV. Through the precise modeling of the detector structure, the agreement between both results has been improved. A surprising result is that in the PGNAA method the agreement between the MCNP simulation and experiment will be better by using a suitable neutron shield for NaI detector in order to prevent the activation of NaI (Tl) and a proper gamma-shield to attenuate the high-rate 4.438 MeV gamma-ray, (241)Am-Be gamma-ray component. PMID:17485218

  16. Statistical and quadrant-hole analysis of the turbulence characteristics in a 3 x 3 wind turbine array boundary layer

    NASA Astrophysics Data System (ADS)

    Gibson, Max; Kang, Hyung-Suk; Meneveau, Charles; Bayoan Cal, Raul

    2009-11-01

    Data from a wind-tunnel experiment on the flow within a 3 x 3 array of lightly loaded wind turbine models operating inside a turbulent boundary layer over a rough surface are analyzed. The data are acquired using X hot-wire anemometry and the focus of the analysis is on the possible differences of the flow structures above and below the canopy of wind turbines. Here this question is addressed using quadrant analysis. Conditional averages of turbulent dissipation (a 1-D surrogate) at various heights at 5 diameters downstream is performed for each of the 4 quadrants as well as different ``hole-sizes.'' The results imply significantly less inter-scale correlations in the low-shear region at the bottom of the wind turbine wake than at other wake locations. Inter-scale correlations above and below the wake are also significantly greater than at that low-shear region. Spectral analysis is performed to determine which scales are mostly responsible for the various levels of Reynolds stresses as functions of position in the wind turbine wake.

  17. Characterization of a Solid Oxide Fuel Cell Gas Turbine Hybrid System Based on a Factorial Design of Experiments Using Hardware Simulation

    SciTech Connect

    Restrepo, Bernardo; Banta, Larry E.; Tucker, David

    2012-10-01

    A full factorial experimental design and a replicated fractional factorial design were carried out using the Hybrid Performance (HyPer) project facility installed at the National Energy Technology Laboratory (NETL), U.S. Department of Energy to simulate gasifer/fuel cell/turbine hybrid power systems. The HyPer facility uses hardware in the loop (HIL) technology that couples a modified recuperated gas turbine cycle with hardware driven by a solid oxide fuel cell model. A 34 full factorial design (FFD) was selected to study the effects of four factors: cold-air, hot-air, bleed-air bypass valves, and the electric load on different parameters such as cathode and turbine inlet temperatures, pressure and mass flow. The results obtained, compared with former results where the experiments were made using one-factor-at-a-time (OFAT), show that no strong interactions between the factors are present in the different parameters of the system. This work also presents a fractional factorial design (ffd) 34-2 in order to analyze replication of the experiments. In addition, a new envelope is described based on the results of the design of experiments (DoE), compared with OFAT experiments, and analyzed in an off-design integrated fuel cell/gas turbine framework. This paper describes the methodology, strategy, and results of these experiments that bring new knowledge concerning the operating state space for this kind of power generation system.

  18. A review of metabolic and enzymatic engineering strategies for designing and optimizing performance of microbial cell factories

    PubMed Central

    Fisher, Amanda K.; Freedman, Benjamin G.; Bevan, David R.; Senger, Ryan S.

    2014-01-01

    Microbial cell factories (MCFs) are of considerable interest to convert low value renewable substrates to biofuels and high value chemicals. This review highlights the progress of computational models for the rational design of an MCF to produce a target bio-commodity. In particular, the rational design of an MCF involves: (i) product selection, (ii) de novo biosynthetic pathway identification (i.e., rational, heterologous, or artificial), (iii) MCF chassis selection, (iv) enzyme engineering of promiscuity to enable the formation of new products, and (v) metabolic engineering to ensure optimal use of the pathway by the MCF host. Computational tools such as (i) de novo biosynthetic pathway builders, (ii) docking, (iii) molecular dynamics (MD) and steered MD (SMD), and (iv) genome-scale metabolic flux modeling all play critical roles in the rational design of an MCF. Genome-scale metabolic flux models are of considerable use to the design process since they can reveal metabolic capabilities of MCF hosts. These can be used for host selection as well as optimizing precursors and cofactors of artificial de novo biosynthetic pathways. In addition, recent advances in genome-scale modeling have enabled the derivation of metabolic engineering strategies, which can be implemented using the genomic tools reviewed here as well. PMID:25379147

  19. Plant Factory

    NASA Astrophysics Data System (ADS)

    Ikeda, Hideo

    Recently, much attention is paid on the plant factory, as it enable to grow plants stably under extraordinary climate condition such as high and/or low air temperature and less rain. Lots of questions such as decreasing investing cost, realizing stable plant production and developing new growing technique should be solved for making popular this growing system. However, I think that we can introduce a highly developed Japanese industrial now-how to plant factory system and can produce a business chance to the world market.

  20. A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania.

    PubMed

    Kramer, Randall A; Mboera, Leonard E G; Senkoro, Kesheni; Lesser, Adriane; Shayo, Elizabeth H; Paul, Christopher J; Miranda, Marie Lynn

    2014-05-01

    The optimization of malaria control strategies is complicated by constraints posed by local health systems, infrastructure, limited resources, and the complex interactions between infection, disease, and treatment. The purpose of this paper is to describe the protocol of a randomized factorial study designed to address this research gap. This project will evaluate two malaria control interventions in Mvomero District, Tanzania: (1) a disease management strategy involving early detection and treatment by community health workers using rapid diagnostic technology; and (2) vector control through community-supported larviciding. Six study villages were assigned to each of four groups (control, early detection and treatment, larviciding, and early detection and treatment plus larviciding). The primary endpoint of interest was change in malaria infection prevalence across the intervention groups measured during annual longitudinal cross-sectional surveys. Recurring entomological surveying, household surveying, and focus group discussions will provide additional valuable insights. At baseline, 962 households across all 24 villages participated in a household survey; 2,884 members from 720 of these households participated in subsequent malariometric surveying. The study design will allow us to estimate the effect sizes of different intervention mixtures. Careful documentation of our study protocol may also serve other researchers designing field-based intervention trials. PMID:24840349

  1. A Randomized Longitudinal Factorial Design to Assess Malaria Vector Control and Disease Management Interventions in Rural Tanzania

    PubMed Central

    Kramer, Randall A.; Mboera, Leonard E. G.; Senkoro, Kesheni; Lesser, Adriane; Shayo, Elizabeth H.; Paul, Christopher J.; Miranda, Marie Lynn

    2014-01-01

    The optimization of malaria control strategies is complicated by constraints posed by local health systems, infrastructure, limited resources, and the complex interactions between infection, disease, and treatment. The purpose of this paper is to describe the protocol of a randomized factorial study designed to address this research gap. This project will evaluate two malaria control interventions in Mvomero District, Tanzania: (1) a disease management strategy involving early detection and treatment by community health workers using rapid diagnostic technology; and (2) vector control through community-supported larviciding. Six study villages were assigned to each of four groups (control, early detection and treatment, larviciding, and early detection and treatment plus larviciding). The primary endpoint of interest was change in malaria infection prevalence across the intervention groups measured during annual longitudinal cross-sectional surveys. Recurring entomological surveying, household surveying, and focus group discussions will provide additional valuable insights. At baseline, 962 households across all 24 villages participated in a household survey; 2,884 members from 720 of these households participated in subsequent malariometric surveying. The study design will allow us to estimate the effect sizes of different intervention mixtures. Careful documentation of our study protocol may also serve other researchers designing field-based intervention trials. PMID:24840349

  2. A New Interaction Region Design for the Super-B Factory

    SciTech Connect

    Sullivan, Michael; Bertsche, Kirk; Bettoni, Simona; Paoloni, Eugenio; Raimondi, Pantaleo; Vobly, Pavel; /Novosibirsk, IYF

    2012-07-06

    A final focus magnet design that uses super-ferric magnets is introduced for the SuperB interaction region. The baseline design has air-core super-conducting quadrupoles. This idea instead uses super-conducting wire in an iron yoke. The iron is in the shape of a Panofsky quadrupole and this allows two quadrupoles to be side-by-side with no intervening iron as long as the gradients of the two quads are equal. This feature allows us to move in as close as possible to the collision point and minimize the beta functions in the interaction region. The superferric design has advantages as well as drawbacks and we will discuss these in the paper.

  3. Computational tools and lattice design for the PEP-II B-Factory

    SciTech Connect

    Cai Yunhai; Irwin, John; Nosochkov, Yuri; Yan, Yiton

    1997-02-01

    Several accelerator codes were used to design the PEP-II lattices, ranging from matrix-based codes, such as MAD and DIMAD, to symplectic-integrator codes, such as TRACY and DESPOT. In addition to element-by-element tracking, we constructed maps to determine aberration strengths. Furthermore, we have developed a fast and reliable method (nPB tracking) to track particles with a one-turn map. This new technique allows us to evaluate performance of the lattices on the entire tune-plane. Recently, we designed and implemented an object-oriented code in C++ called LEGO which integrates and expands upon TRACY and DESPOT.

  4. Recirculating linacs for a neutrino factory - Arc optics design and optimization

    SciTech Connect

    Alex Bogacz; Valeri Lebedev

    2001-10-21

    A conceptual lattice design for a muon accelerator based on recirculating linacs (Nucl. Instr. and Meth. A 472 (2001) 499, these proceedings) is presented here. The challenge of accelerating and transporting a large phase space of short-lived muons is answered here by presenting a proof-of-principle lattice design for a recirculating linac accelerator. It is the centerpiece of a chain of accelerators consisting of a 3GeV linac and two consecutive recirculating linear accelerators, which facilitates acceleration starting after ionization cooling at 190MeV/c and proceeding to 50GeV. Beam transport issues for large-momentum-spread beams are accommodated by appropriate lattice design choices. The resulting arc optics is further optimized with a sextupole correction to suppress chromatic effects contributing to the emittance dilution. The presented proof-of-principle design of the arc optics with horizontal separation of multi-pass beams can be extended to all passes in both recirculating linacs.

  5. Recirculating linacs for a neutrino factory - Arc optics design and optimization

    SciTech Connect

    Valeri Lebedev; S. Bogacz

    2001-10-25

    A conceptual lattice design for a muon accelerator based on recirculating linacs (Nucl. Instr. and Meth. A 472 (2001) 499, these proceedings) is presented here. The challenge of accelerating and transporting a large phase space of short-lived muons is answered here by presenting a proof-of-principle lattice design for a recirculating linac accelerator. It is the centerpiece of a chain of accelerators consisting of a 3 GeV linac and two consecutive recirculating linear accelerators, which facilitates acceleration starting after ionization cooling at 190 MeV/c and proceeding to 50 GeV. Beam transport issues for large-momentum-spread beams are accommodated by appropriate lattice design choices. The resulting arc optics is further optimized with a sextupole correction to suppress chromatic effects contributing to the emittance dilution. The presented proof-of-principle design of the arc optics with horizontal separation of multi-pass beams can be extended to all passes in both recirculating linacs.

  6. PEP-II asymmetric B Factory: Design update and R&D results

    SciTech Connect

    Zisman, M.S.; Bell, R.A.; Dorfan, J.; Schwarz, H.; Barletta, W.A.; Calderon, M.

    1992-07-01

    PEP-II, a 9 GeV {times} 3.1 GeV e{sup +}e{sup {minus}} collider with a design luminosity of 3 {times} 10{sup 33} cm{sup {minus}2}{sub s}{sup {minus}1}, was proposed jointly by SLAC, LBL, and LLNL. Recent efforts have continued towards an optimized design. In addition, an aggressive R&D program is under way to validate our design choices. Fabrication of a low-power prototype RF cavity is complete, and impedance measurements are beginning. A 500-kW, 476-MHz klystron has been completed; it will be used for testing both high-power RF windows and a prototype high-power cavity (now under design in collaboration with Chalk River Laboratory). Vacuum studies have demonstrated that chambers with suitable photodesorption properties can be fabricated. A mockup of the two-ring arc area has been completed and used to investigate alignment and stability issues. The PEP-II project is ready to begin construction as soon as funds become available.

  7. PEP-II Asymmetric B Factory: Designs Update and R& D Results

    SciTech Connect

    Zisman, M

    2004-07-22

    PEP-II, a 9 GeV x 3.1 GeV e{sup +}e{sup -} collider with a design luminosity of 3 x 10{sup 33} cm{sup -2}s{sup -1}, was proposed jointly by SLAC, LBL, and LLNL. Recent efforts have continued towards an optimized design. In addition, an aggressive R&D program is under way to validate our design choices. Fabrication of a low-power prototype RF cavity is complete, and impedance measurements are beginning. A 500-kW, 476-MHz klystron has been completed; it will be used for testing both high-power RF windows and a prototype high-power cavity (now under design in collaboration with Chalk River Laboratory). Vacuum studies have demonstrated that chambers with suitable photodesorption properties can be fabricated. A mock-up of the two-ring arc area has been completed and used to investigate alignment and stability issues. The PEP-II project is ready to begin construction as soon as funds become available.

  8. Design Concept of a Gamma-gamma Higgs Factory Driven by Thin Laser Targets and Energy Recovery Linacs

    SciTech Connect

    Zhang, Yuhong

    2013-06-01

    A gamma-gamma collider has long been considered an option for a Higgs Factory. Such photon colliders usually rely on Compton back-scattering for generating high energy gamma photons and further Higgs bosons through gamma-gamma collisions. The presently existing proposals or design concepts all have chosen a very thick laser target (i.e., high laser photon intensity) for Compton scatterings. In this paper, we present a new design concept of a gamma-gamma collider utilizing a thin laser target (i.e., relatively low photon density), thus leading to a low electron to gamma photon conversion rate. This new concept eliminates most useless and harmful low energy soft gamma photons from multiple Compton scattering so the detector background is improved. It also greatly relaxes the requirement of the high peak power of the laser, a significant technical challenge. A high luminosity for such a gamma-gamma collider can be achieved through an increase of the bunch repetition rate and current of the driven electron beam. Further, multi-pass recirculating linac could greatly reduce the linac cost and energy recovery is required to reduce the needed RF power.

  9. Enhancement of Solubility of Lamotrigine by Solid Dispersion and Development of Orally Disintegrating Tablets Using 32 Full Factorial Design

    PubMed Central

    Singh, Jatinderpal; Garg, Rajeev; Gupta, Ghanshyam Das

    2015-01-01

    Present investigation deals with the preparation and evaluation of orally disintegrating tablets (ODTs) of lamotrigine using β-cyclodextrin and PVP-K30 as polymers for the preparation of solid dispersion which help in enhancement of aqueous solubility of this BCS CLASS-II drug and sodium starch glycolate (SSG) and crospovidone as a superdisintegrating agent, to reduce disintegration time. The ODTs were prepared by direct compression method. Nine formulations were developed with different ratios of superdisintegrating agents. All the formulations were evaluated for disintegration time, weight variation, hardness, friability, drug content uniformity, wetting time, and in vitro drug release study. In vitro drug release study was performed using United States Pharmacopoeia (USP) type 2 dissolution test apparatus employing paddle stirrer at 50 rpm using 900 mL of 0.1 N HCl maintained at 37°C ± 0.5°C as the dissolution medium. On the basis of evaluation parameters formulations were prepared using β-CD 1 : 1 solid dispersion. Then 32 full factorial design was applied using SSG and crospovidone in different ratios suggested by using design expert 8.0.7.1 and optimized formulation was prepared using amount of SSG and crospovidone as suggested by the software. The optimized formulation prepared had disintegrating time of 15 s, wetting time of 24 s, and % friability of 0.55. PMID:26634173

  10. Computational tools and lattice design for the PEP-II B-Factory

    SciTech Connect

    Cai, Y.; Irwin, J.; Nosochkov, Y.; Yan, Y.

    1997-02-01

    Several accelerator codes were used to design the PEP-II lattices, ranging from matrix-based codes, such as MAD and DIMAD, to symplectic-integrator codes, such as TRACY and DESPOT. In addition to element-by-element tracking, we constructed maps to determine aberration strengths. Furthermore, we have developed a fast and reliable method (nPB tracking) to track particles with a one-turn map. This new technique allows us to evaluate performance of the lattices on the entire tune-plane. Recently, we designed and implemented an object-oriented code in C++ called LEGO which integrates and expands upon TRACY and DESPOT. {copyright} {ital 1997 American Institute of Physics.}

  11. Treatment of municipal landfill leachate by catalytic wet air oxidation: Assessment of the role of operating parameters by factorial design

    SciTech Connect

    Anglada, Angela; Urtiaga, Ane; Ortiz, Inmaculada; Diamadopoulos, Evan

    2011-08-15

    Highlights: > Landfill leachates can be treated effectively by catalytic wet oxidation. > Addition of H{sub 2}O{sub 2} in the presence of transition metals promotes degradation. > Factorial design evaluates the statistically significant operating conditions. > H{sub 2}O{sub 2}, reaction time and temperature are critical in determining performance. - Abstract: The wet air oxidation (WAO) of municipal landfill leachate catalyzed by cupric ions and promoted by hydrogen peroxide was investigated. The effect of operating conditions such as WAO treatment time (15-30 min), temperature (160-200 deg. C), Cu{sup 2+} concentration (250-750 mg L{sup -1}) and H{sub 2}O{sub 2} concentration (0-1500 mg L{sup -1}) on chemical oxygen demand (COD) removal was investigated by factorial design considering a two-stage, sequential process comprising the heating-up of the reactor and the actual WAO. The leachate, at an initial COD of 4920 mg L{sup -1}, was acidified to pH 3 leading to 31% COD decrease presumably due to the coagulation/precipitation of colloidal and other organic matter. During the 45 min long heating-up period of the WAO reactor under an inert atmosphere, COD removal values up to 35% (based on the initial COD value) were recorded as a result of the catalytic decomposition of H{sub 2}O{sub 2} to reactive hydroxyl radicals. WAO at 2.5 MPa oxygen partial pressure advanced treatment further; for example, 22 min of oxidation at 200 deg. C, 250 mg L{sup -1} Cu{sup 2+} and 0-1500 mg L{sup -1} H{sub 2}O{sub 2} resulted in an overall (i.e. including acidification and heating-up) COD reduction of 78%. Amongst the operating variables in question, temperature had the strongest influence on both the heating-up and WAO stages, while H{sub 2}O{sub 2} concentration strongly affected the former and reaction time the latter. Nonetheless, the effects of temperature and H{sub 2}O{sub 2} concentration were found to depend on the concentration levels of catalyst as suggested by the

  12. High-power RF window design for the PEP-II B Factory

    SciTech Connect

    Neubauer, M.; Hodgson, J.; Ng, C.; Schwarz, H.; Skarpaas, K.; Kroll, N. |; Rimmer, R.

    1994-06-01

    We describe the design of RF windows to transmit up to 500 kW CW to the PEP-II 476 MHz cavities. RF analysis of the windows using high-frequency simulation codes are described. These provide information about the power loss distribution in the ceramic and tim matching properties of the structure. Finite-element analyses of the resulting temperature distribution and thermal stresses are presented. Fabrication methods including a proposed scheme to compensate for thermal expansion s are discussed and hardware tests to validate this approach are described. The effects of surface coatings (intentional and otherwise) and the application of air cooling are considered.

  13. Design Concept for nu-STORM: An Initial Very Low-Energy Neutrino Factory

    SciTech Connect

    Bross, A.; Geer, S.; Liu, A.; Neuffer, D.; Popovic, M.; Ankenbrandt, C.; Roberts, T.; /MUONS Inc., Batavia

    2012-05-01

    We present a design concept for a {nu} source from a STORage ring for Muons ({nu}STORM). In this initial design a high-intensity proton beam produces {approx}5 GeV pions that provide muons that are captured using 'stochastic injection' within a 3.6 GeV racetrack storage ring. In 'stochastic injection', the {approx}5 GeV pion beam is transported from the target into the storage ring, dispersion-matched into a long straight section. (Circulating and injection orbits are separated by momentum.) Decays within that straight section provide muons that are within the {approx}3.6 GeV/c ring momentum acceptance and are stored for the muon lifetime of {approx}1000 turns. Muon (and pion) decays in the long straight sections provide neutrino beams of precisely known flux and flavor that can be used for precision measurements of electron and muon neutrino interactions, and neutrino oscillations or disappearance at L/E = {approx}1m/MeV. The facility is described, and variations are discussed.

  14. Recent SuperB Design Choices Improve Next-Generation e e___ B-Factory Collider

    SciTech Connect

    Wittmer, W.; Bertsche, K.; Chao, A.; Novokhatski, A.; Nosochkov, Y.; Seeman, J.; Sullivan, M.K.; Wienands, U.; Bogomyagkov, A.V.; Levichev, E.; Nikitin, S.; Piminov, P.; Shatilov, D.; Sinyatkin, S.; Vobly, P.; Okunev, I.N.; Bolzon, B.; Brunetti, L.; Jeremie, A.; Biagini, M.E.; Boni, R.; /Frascati /INFN, Pisa /Pisa U. /INFN, Genoa /Genoa U. /CERN /Orsay, LAL /Saclay

    2011-08-19

    The SuperB international team continues to optimize the design of an electron-positron collider, which will allow the enhanced study of the origins of flavor physics. The project combines the best features of a linear collider (high single-collision luminosity) and a storage-ring collider (high repetition rate), bringing together all accelerator physics aspects to make a very high luminosity of 10{sup 36} cm{sup -2} sec{sup -1}. This asymmetric-energy collider with a polarized electron beam will produce hundreds of millions of B-mesons at the {Upsilon}(4S) resonance. The present design is based on extremely low emittance beams colliding at a large Piwinski angle to allow very low {beta}*{sub y} without the need for ultra short bunches. Use of crab-waist sextupoles will enhance the luminosity, suppressing dangerous resonances and allowing for a higher beam-beam parameter. The project has flexible beam parameters, improved dynamic aperture, and spin-rotators in the Low Energy Ring for longitudinal polarization of the electron beam at the Interaction Point. Optimized for best colliding-beam performance, the facility may also provide high-brightness photon beams for synchrotron radiation applications.

  15. Fractional Factorial Experiment Designs to Minimize Configuration Changes in Wind Tunnel Testing

    NASA Technical Reports Server (NTRS)

    DeLoach, Richard; Cler, Daniel L.; Graham, Albert B.

    2002-01-01

    This paper serves as a tutorial to introduce the wind tunnel research community to configuration experiment designs that can satisfy resource constraints in a configuration study involving several variables, without arbitrarily eliminating any of them from the experiment initially. The special case of a configuration study featuring variables at two levels is examined in detail. This is the type of study in which each configuration variable has two natural states - 'on or off', 'deployed or not deployed', 'low or high', and so forth. The basic principles are illustrated by results obtained in configuration studies conducted in the Langley National Transonic Facility and in the ViGYAN Low Speed Tunnel in Hampton, Virginia. The crucial role of interactions among configuration variables is highlighted with an illustration of difficulties that can be encountered when they are not properly taken into account.

  16. Design and performance of a compact scanning transmission X-ray microscope at the Photon Factory.

    PubMed

    Takeichi, Y; Inami, N; Suga, H; Miyamoto, C; Ueno, T; Mase, K; Takahashi, Y; Ono, K

    2016-01-01

    We present a new compact instrument designed for scanning transmission X-ray microscopy. It has piezo-driven linear stages, making it small and light. Optical components from the virtual source point to the detector are located on a single optical table, resulting in a portable instrument that can be operated at a general-purpose spectroscopy beamline without requiring any major reconstruction. Careful consideration has been given to solving the vibration problem common to high-resolution microscopy, so as not to affect the spatial resolution determined by the Fresnel zone plate. Results on bacteriogenic iron oxides, single particle aerosols, and rare-earth permanent magnets are presented as examples of its performance under diverse applications. PMID:26827325

  17. Design and performance of a compact scanning transmission X-ray microscope at the Photon Factory

    NASA Astrophysics Data System (ADS)

    Takeichi, Y.; Inami, N.; Suga, H.; Miyamoto, C.; Ueno, T.; Mase, K.; Takahashi, Y.; Ono, K.

    2016-01-01

    We present a new compact instrument designed for scanning transmission X-ray microscopy. It has piezo-driven linear stages, making it small and light. Optical components from the virtual source point to the detector are located on a single optical table, resulting in a portable instrument that can be operated at a general-purpose spectroscopy beamline without requiring any major reconstruction. Careful consideration has been given to solving the vibration problem common to high-resolution microscopy, so as not to affect the spatial resolution determined by the Fresnel zone plate. Results on bacteriogenic iron oxides, single particle aerosols, and rare-earth permanent magnets are presented as examples of its performance under diverse applications.

  18. Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery

    NASA Astrophysics Data System (ADS)

    Gonzalez-Mira, E.; Egea, M. A.; Souto, E. B.; Calpena, A. C.; García, M. L.

    2011-01-01

    The purpose of this study was to design and optimize a new topical delivery system for ocular administration of flurbiprofen (FB), based on lipid nanoparticles. These particles, called nanostructured lipid carriers (NLC), were composed of a fatty acid (stearic acid (SA)) as the solid lipid and a mixture of Miglyol® 812 and castor oil (CO) as the liquid lipids, prepared by the hot high pressure homogenization method. After selecting the critical variables influencing the physicochemical characteristics of the NLC (the liquid lipid (i.e. oil) concentration with respect to the total lipid (cOil/L (wt%)), the surfactant and the flurbiprofen concentration, on particle size, polydispersity index and encapsulation efficiency), a three-factor five-level central rotatable composite design was employed to plan and perform the experiments. Morphological examination, crystallinity and stability studies were also performed to accomplish the optimization study. The results showed that increasing cOil/L (wt%) was followed by an enhanced tendency to produce smaller particles, but the liquid to solid lipid proportion should not exceed 30 wt% due to destabilization problems. Therefore, a 70:30 ratio of SA to oil (miglyol + CO) was selected to develop an optimal NLC formulation. The smaller particles obtained when increasing surfactant concentration led to the selection of 3.2 wt% of Tween® 80 (non-ionic surfactant). The positive effect of the increase in FB concentration on the encapsulation efficiency (EE) and its total solubilization in the lipid matrix led to the selection of 0.25 wt% of FB in the formulation. The optimal NLC showed an appropriate average size for ophthalmic administration (228.3 nm) with a narrow size distribution (0.156), negatively charged surface (-33.3 mV) and high EE (~90%). The in vitro experiments proved that sustained release FB was achieved using NLC as drug carriers. Optimal NLC formulation did not show toxicity on ocular tissues.

  19. Custom fractional factorial designs to develop atorvastatin self-nanoemulsifying and nanosuspension delivery systems – enhancement of oral bioavailability

    PubMed Central

    Hashem, Fahima M; Al-Sawahli, Majid M; Nasr, Mohamed; Ahmed, Osama AA

    2015-01-01

    Poor water solubility of a drug is a major challenge in drug delivery research and a main cause for limited bioavailability and pharmacokinetic parameters. This work aims to utilize custom fractional factorial design to assess the development of self-nanoemulsifying drug delivery systems (SNEDDS) and solid nanosuspensions (NS) in order to enhance the oral delivery of atorvastatin (ATR). According to the design, 14 experimental runs of ATR SNEDDS were formulated utilizing the highly ATR solubilizing SNEDDS components: oleic acid, Tween 80, and propylene glycol. In addition, 12 runs of NS were formulated by the antisolvent precipitation–ultrasonication method. Optimized formulations of SNEDDS and solid NS, deduced from the design, were characterized. Optimized SNEDDS formula exhibited mean globule size of 73.5 nm, zeta potential magnitude of −24.1 mV, and 13.5 μs/cm of electrical conductivity. Optimized solid NS formula exhibited mean particle size of 260.3 nm, 7.4 mV of zeta potential, and 93.2% of yield percentage. Transmission electron microscopy showed SNEDDS droplets formula as discrete spheres. The solid NS morphology showed flaky nanoparticles with irregular shapes using scanning electron microscopy. The release behavior of the optimized SNEDDS formula showed 56.78% of cumulative ATR release after 10 minutes. Solid NS formula showed lower rate of release in the first 30 minutes. Bioavailability estimation in Wistar albino rats revealed an augmentation in ATR bioavailability, relative to ATR suspension and the commercial tablets, from optimized ATR SNEDDS and NS formulations by 193.81% and 155.31%, respectively. The findings of this work showed that the optimized nanocarriers enhance the oral delivery and pharmacokinetic profile of ATR. PMID:26150693

  20. Modelling aluminium leaching into food from different foodware materials with multi-level factorial design of experiments.

    PubMed

    Fekete, Veronika; Deconinck, Eric; Bolle, Fabien; Van Loco, Joris

    2012-08-01

    To estimate the contribution of aluminium (Al) leaching from different materials used for food preparation and serving to the dietary Al intake, Al release from foodware typically used in everyday life was investigated using multilevel factorial design (MFD) of experiments. For Al characterisation, sample preparation and an analytical method using inductively coupled plasma atomic emission spectroscopy was developed and validated. Parameter influence (temperature: x₁, contact time: x₂, pH: x₃, salt concentration: x₄, viscosity: x₅), was evaluated with analysis of variance suggesting that the influence of viscosity is not significant compared to the other four studied parameters. Therefore, predictive, exponential quadratic regression models were established with x₁-x₄. Cross-validation and a set of independent experiments in real food products were used to test the prediction force of the different models. They both suggest that the quality of the models established for Al foil, Al plate and ceramic ware is satisfactory, but less good for glassware and stainless steel. Indeed, in the studied conditions, leaching from these latter food wares was often close to or even below the limit of quantification suggesting that the principal sources of Al intake from food contact materials during food processing are utensils made of Al and ceramic ware. PMID:22656325

  1. A pilot human pharmacokinetic study and influence of formulation factors on orodispersible tablet incorporating meloxicam solid dispersion using factorial design.

    PubMed

    Aboelwafa, Ahmed A; Fahmy, Rania H

    2012-01-01

    Meloxicam (MLX) suffers from poor aqueous solubility leading to slow absorption following oral administration; hence, immediate release MLX tablet is unsuitable in the treatment of acute pain. This study aims to overcome such a drawback by increasing MLX solubility and dissolution using PEG solid dispersion (SD), then, to investigate the feasibility of incorporating the SD into orodispersible tablets (ODTs). A 2(3) full factorial design was employed to investigate the influence of three formulation variables on MLX ODTs. The selected factors: camphor (X(1)) as pore-forming material, and croscarmellose sodium (X(2)) as superdisintegrant, showed significant positive influence, while PEG content (X(3)) was proved to negatively affect both disintegration and wetting times. In addition, isomalt increased disintegration and wetting times when compared to mannitol as diluents. The pharmacokinetic assessment of the optimum ODT formulation in healthy human subjects proved that the faster MLX dissolution by using PEG solid dispersion at pH 6.8 resulted in more rapid absorption of MLX. The rate of absorption of MLX from ODT was significantly faster (p = 0.030) with a significantly higher peak plasma concentration (P = 0.037) when compared to the marketed immediate release MLX tablet with a mean oral disintegration time of 17 ± 3 s. PMID:20550483

  2. Amino-Functionalization of Carbon Nanotubes by Using a Factorial Design: Human Cardiac Troponin T Immunosensing Application

    PubMed Central

    Freitas, Tatianny A.; Mattos, Alessandra B.; Silva, Bárbara V. M.; Dutra, Rosa F.

    2014-01-01

    A simple amino-functionalization method for carbon nanotubes and its application in an electrochemical immunosensor for detection of the human cardiac troponin T are described. Amino-functionalized carbon nanotubes allow oriented antibodies immobilization via their Fc regions, improving the performance of an immunosensor. Herein multiwalled carbon nanotubes were amino-functionalized by using the ethylenediamine reagent and assays were designed by fractional factorial study associated with Doehlert matrix. Structural modifications in the carbon nanotubes were confirmed by Fourier transform infrared spectroscopy. After amino-functionalization the carbon nanotubes were attached to screen-printed carbon electrode and a sandwich-type immunoassay was performed for measuring the cardiac troponin T. The electrochemical measurements were obtained through hydrogen peroxide reaction with peroxidase conjugated to the secondary antibody. Under optimal conditions, troponin T immunosensor was evaluated in serum samples, which showed a broad linear range (0.02 to 0.32 ng mL−1) and a low limit of detection, 0.016 ng mL−1. This amino platform can be properly used as clinical tool for cardiac troponin T detection in the acute myocardial infarction diagnosis. PMID:25133185

  3. Abrasive resistance of metastable V-Cr-Mn-Ni spheroidal carbide cast irons using the factorial design method

    NASA Astrophysics Data System (ADS)

    Efremenko, V. G.; Shimizu, K.; Cheiliakh, A. P.; Pastukhova, T. V.; Chabak, Yu. G.; Kusumoto, K.

    2016-06-01

    Full factorial design was used to evaluate the two-body abrasive resistance of 3wt%C-4wt%Mn-1.5wt%Ni spheroidal carbide cast irons with varying vanadium (5.0wt%-10.0wt%) and chromium (up to 9.0wt%) contents. The alloys were quenched at 920°C. The regression equation of wear rate as a function of V and Cr contents was proposed. This regression equation shows that the wear rate decreases with increasing V content because of the growth of spheroidal VC carbide amount. Cr influences the overall response in a complex manner both by reducing the wear rate owing to eutectic carbides (M7C3) and by increasing the wear rate though stabilizing austenite to deformation-induced martensite transformation. This transformation is recognized as an important factor in increasing the abrasive response of the alloys. By analyzing the regression equation, the optimal content ranges are found to be 7.5wt%-10.0wt% for V and 2.5wt%-4.5wt% for Cr, which corresponds to the alloys containing 9vol%-15vol% spheroidal VC carbides, 8vol%-16vol% M7C3, and a metastable austenite/martensite matrix. The wear resistance is 1.9-2.3 times that of the traditional 12wt% V-13wt% Mn spheroidal carbide cast iron.

  4. Amidated pectin/sodium carboxymethylcellulose microspheres as a new carrier for colonic drug targeting: Development and optimization by factorial design.

    PubMed

    Gadalla, Hytham H; El-Gibaly, Ibrahim; Soliman, Ghareb M; Mohamed, Fergany A; El-Sayed, Ahmed M

    2016-11-20

    The colon is a promising site for drug targeting owing to its long transit time and mild proteolytic activity. The aim of this study was to prepare new low methoxy amidated pectin/NaCMC microspheres cross-linked by a mixture of Zn(2+) and Al(3+) ions and test their potential for colonic targeting of progesterone. A 2(4) factorial design was carried out to optimize the preparation conditions. High drug entrapment efficiency (82-99%) was obtained and it increased with increasing drug concentration but decreased with increasing polymer concentration. Drug release rate was directly proportional to the microsphere drug content and inversely related to Al(3+) ion concentration. Drug release was minimal during the first 3h but was significantly improved in the presence of 1% rat caecal contents, confirming the microsphere potential for colonic delivery. The microspheres achieved >2.3-fold enhancement of colonic progesterone permeability. These results confirm the viability of the produced microspheres as colon-targeted drug delivery vehicle. PMID:27561525

  5. Chemometric study of the influence of instrumental parameters on ESI-MS analyte response using full factorial design

    NASA Astrophysics Data System (ADS)

    Raji, M. A.; Schug, K. A.

    2009-01-01

    Full factorial experimental design technique was used to study the main effects and the interaction effects between instrumental parameters in two mass spectrometers equipped with conventional electrospray ion sources (Thermo LCQ Deca XP and Shimadzu LCMS 2010). Four major parameters (spray voltage, ion transfer capillary temperature, ion transfer capillary voltage, and tube lens voltage) were investigated in both instruments for their contribution to analyte response, leading to a total of 16 experiments performed for each instrument. Significant parameters were identified by plotting the cumulative probability of each treatment against the estimated effects in normal plots. Analysis of variance (ANOVA) was employed to evaluate the statistical significance of the effects of the parameters on ESI-MS analyte response. The results reveal a number of important interactions in addition to the main effects for each instrument. In all the experiments performed, the tube lens voltage (or Q-array dc voltage in LCMS 2010) was found to have significant effects on analyte response in both instruments. The tube lens voltage was also found to interact with the capillary temperature in the case of the LCQ Deca XP and with the spray voltage in the case of the LCMS 2010. The results of these experiments provide important considerations in the instrumental optimization of ionization response for ESI-MS analysis.

  6. Fractional Factorial Design of MALDI-TOF-MS Sample Preparations for the Optimized Detection of Phospholipids and Acylglycerols.

    PubMed

    AlMasoud, Najla; Correa, Elon; Trivedi, Drupad K; Goodacre, Royston

    2016-06-21

    Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has successfully been used for the analysis of high molecular weight compounds, such as proteins and nucleic acids. By contrast, analysis of low molecular weight compounds with this technique has been less successful due to interference from matrix peaks which have a similar mass to the target analyte(s). Recently, a variety of modified matrices and matrix additives have been used to overcome these limitations. An increased interest in lipid analysis arose from the feasibility of correlating these components with many diseases, e.g. atherosclerosis and metabolic dysfunctions. Lipids have a wide range of chemical properties making their analysis difficult with traditional methods. MALDI-TOF-MS shows excellent potential for sensitive and rapid analysis of lipids, and therefore this study focuses on computational-analytical optimization of the analysis of five lipids (4 phospholipids and 1 acylglycerol) in complex mixtures using MALDI-TOF-MS with fractional factorial design (FFD) and Pareto optimality. Five different experimental factors were investigated using FFD which reduced the number of experiments performed by identifying 720 key experiments from a total of 8064 possible analyses. Factors investigated included the following: matrices, matrix preparations, matrix additives, additive concentrations, and deposition methods. This led to a significant reduction in time and cost of sample analysis with near optimal conditions. We discovered that the key factors used to produce high quality spectra were the matrix and use of appropriate matrix additives. PMID:27228355

  7. Enhanced diesel fuel fraction from waste high-density polyethylene and heavy gas oil pyrolysis using factorial design methodology.

    PubMed

    Joppert, Ney; da Silva, Alexsandro Araujo; da Costa Marques, Mônica Regina

    2015-02-01

    Factorial Design Methodology (FDM) was developed to enhance diesel fuel fraction (C9-C23) from waste high-density polyethylene (HDPE) and Heavy Gas Oil (HGO) through co-pyrolysis. FDM was used for optimization of the following reaction parameters: temperature, catalyst and HDPE amounts. The HGO amount was constant (2.00 g) in all experiments. The model optimum conditions were determined to be temperature of 550 °C, HDPE = 0.20 g and no FCC catalyst. Under such conditions, 94% of pyrolytic oil was recovered, of which diesel fuel fraction was 93% (87% diesel fuel fraction yield), no residue was produced and 6% of noncondensable gaseous/volatile fraction was obtained. Seeking to reduce the cost due to high process temperatures, the impact of using higher catalyst content (25%) with a lower temperature (500 °C) was investigated. Under these conditions, 88% of pyrolytic oil was recovered (diesel fuel fraction yield was also 87%) as well as 12% of the noncondensable gaseous/volatile fraction. No waste was produced in these conditions, being an environmentally friendly approach for recycling the waste plastic. This paper demonstrated the usefulness of using FDM to predict and to optimize diesel fuel fraction yield with a great reduction in the number of experiments. PMID:25532672

  8. Synergistic Effect of Hydrotrope and Surfactant on Solubility and Dissolution of Atorvastatin Calcium: Screening Factorial Design Followed by Ratio Optimization

    PubMed Central

    Patel, V. F.; Sarai, J.

    2014-01-01

    The present study was aimed at investigating the effect of hydrotrope and surfactant on poor solubility of atorvastatin calcium. Excipients screening followed by factorial design was performed to study effect of excipients and manufacturing methods on solubility of drug. Three independent factors (carrier, surfactant and manufacturing method) were evaluated at two levels using solubility as a dependant variable. Solid-state characterisation was performed using Fourier transform infrared spectroscopy and differential scanning calorimetry. Optimised complex were incorporated into orally disintegrating micro tablets and in vitro dissolution test was performed. Nicotinamide, Plasdone and sodium dodecyl sulphate were emerged as promising excipients from excipient screening. General regression analysis revealed only the type of carrier has significantly enhanced (P<0.05) the solubility of drug while other factors were found to be nonsignificant. Ratio optimisation trial revealed that drug to nicotinamide ratio is more critical in enhancing the solubility of drug (40 fold increases in solubility compared to pure drug) in comparison to drug-surfactant ratio; however the presence of surfactant deemed essential. Significantly higher rate and extent of dissolution was observed from solid dispersion complex and tablets compared to dissolution of pure drug (P<0.05). Study revealed hydrotrope and surfactant have synergistic effect on solubility and dissolution of atorvastatin calcium and this can be explored further. PMID:25593381

  9. The Old Factory

    ERIC Educational Resources Information Center

    Roman, Harry T.

    2007-01-01

    Technology education is not just about things, systems, and processes. It can also be about history, people, technological change, and impacts on society. In this design challenge, one uses technology education principles and ideas to convert an old factory into a museum and learning center. The challenge with this historical resource is to think…

  10. Nanoemulsions containing a synthetic chalcone as an alternative for treating cutaneous leshmaniasis: optimization using a full factorial design

    PubMed Central

    de Mattos, Cristiane Bastos; Argenta, Débora Fretes; Melchiades, Gabriela de Lima; Sechini Cordeiro, Marlon Norberto; Tonini, Maiko Luis; Moraes, Milene Hoehr; Weber, Tanara Beatriz; Roman, Silvane Souza; Nunes, Ricardo José; Teixeira, Helder Ferreira; Steindel, Mário; Koester, Letícia Scherer

    2015-01-01

    Nanoemulsions are drug delivery systems that may increase the penetration of lipophilic compounds through the skin, enhancing their topical effect. Chalcones are compounds of low water solubility that have been described as promising molecules for the treatment of cutaneous leishmaniasis (CL). In this context, the aim of this work was to optimize the development of a nanoemulsion containing a synthetic chalcone for CL treatment using a 22 full factorial design. The formulations were prepared by spontaneous emulsification and the experimental design studied the influence of two independent variables (type of surfactant – soybean lecithin or sorbitan monooleate and type of co-surfactants – polysorbate 20 or polysorbate 80) on the physicochemical characteristics of the nanoemulsions, as well as on the skin permeation/retention of the synthetic chalcone in porcine skin. In order to evaluate the stability of the systems, the antileishmanial assay was performed against Leishmania amazonensis 24 hours and 60 days after the preparation of the nanoemulsions. The formulation composed of soybean lecithin and polysorbate 20 presented suitable physicochemical characteristics (droplet size 171.9 nm; polydispersity index 0.14; zeta potential −39.43 mV; pH 5.16; and viscosity 2.00 cP), drug content (91.09%) and the highest retention in dermis (3.03 µg·g−1) – the main response of interest – confirmed by confocal microscopy. This formulation also presented better stability of leishmanicidal activity in vitro against L. amazonensis amastigote forms (half maximal inhibitory concentration value 0.32±0.05 µM), which confirmed the potential of the nanoemulsion soybean lecithin and polysorbate 20 for CL treatment. PMID:26366075

  11. Testing Nelder-Mead based repulsion algorithms for multiple roots of nonlinear systems via a two-level factorial design of experiments.

    PubMed

    Ramadas, Gisela C V; Rocha, Ana Maria A C; Fernandes, Edite M G P

    2015-01-01

    This paper addresses the challenging task of computing multiple roots of a system of nonlinear equations. A repulsion algorithm that invokes the Nelder-Mead (N-M) local search method and uses a penalty-type merit function based on the error function, known as 'erf', is presented. In the N-M algorithm context, different strategies are proposed to enhance the quality of the solutions and improve the overall efficiency. The main goal of this paper is to use a two-level factorial design of experiments to analyze the statistical significance of the observed differences in selected performance criteria produced when testing different strategies in the N-M based repulsion algorithm. The main goal of this paper is to use a two-level factorial design of experiments to analyze the statistical significance of the observed differences in selected performance criteria produced when testing different strategies in the N-M based repulsion algorithm. PMID:25875591

  12. Testing Nelder-Mead Based Repulsion Algorithms for Multiple Roots of Nonlinear Systems via a Two-Level Factorial Design of Experiments

    PubMed Central

    Fernandes, Edite M. G. P.

    2015-01-01

    This paper addresses the challenging task of computing multiple roots of a system of nonlinear equations. A repulsion algorithm that invokes the Nelder-Mead (N-M) local search method and uses a penalty-type merit function based on the error function, known as ‘erf’, is presented. In the N-M algorithm context, different strategies are proposed to enhance the quality of the solutions and improve the overall efficiency. The main goal of this paper is to use a two-level factorial design of experiments to analyze the statistical significance of the observed differences in selected performance criteria produced when testing different strategies in the N-M based repulsion algorithm. The main goal of this paper is to use a two-level factorial design of experiments to analyze the statistical significance of the observed differences in selected performance criteria produced when testing different strategies in the N-M based repulsion algorithm. PMID:25875591

  13. Formulation and evaluation of self-emulsifying orlistat tablet to enhance drug release and in vivo performance: factorial design approach.

    PubMed

    Gade, Mukund Maruti; Hurkadale, Pramod Jayadevappa

    2016-06-01

    The purpose of the present research work was to formulate, evaluate, and optimize self-emulsifying orlistat tablet to enhance drug release followed by in vivo antiobesity activity in Wistar rats. Initially, the solubility of orlistat was determined in different natural oils, surfactant, and co-surfactants. Self-emulsifying drug delivery system (SEDDS) was prepared by using castor oil, Tween 80, and Capryol PGMC as components. Liquid SEDDS evaluated for globule size and emulsification time. A 3(2) full factorial design was utilized for the optimization purpose. Formulation variables such as quantity of oil (X1) and ratio of surfactant to co-surfactant (X2) were investigated for their effect on globule size and emulsification time. Optimized formulation with minimum globule size was freeze-dried which further compressed into the tablet. Finally, optimized formulation evaluated for the in vitro drug release study followed by weight losing potential in Wistar rats. Globule size and emulsification time for the optimized formulation were found to be 96.4 ± 8.5 nm and 26 ± 4 s, respectively. Fourier transform infra red spectroscopy (FTIR) studies indicated that there was no interaction between drug and excipients. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) study revealed that there was the conversion of crystalline orlistat to the amorphous form. Orlistat release from the self-emulsifying tablet formulation was faster with higher weight reduction potential in Wistar rats than the marketed formulation. Increased in vitro drug release with considerable in vivo weight loss by self-emulsifying tablet suggests that the SEDDS could serve as potential formulation strategy for orlistat. PMID:27037924

  14. Factorial designed 5-fluorouracil-loaded microsponges and calcium pectinate beads plugged in hydroxypropyl methylcellulose capsules for colorectal cancer

    PubMed Central

    Gupta, Ankita; Tiwari, Gaurav; Tiwari, Ruchi; Srivastava, Rishabh

    2015-01-01

    Introduction: The work was aimed to develop an enteric-coated hydroxypropyl methylcellulose (HPMC) capsules (ECHC) plugged with 5-fluorouracil (5-FU)-loaded microsponges in combination with calcium pectinate beads. Materials and Methods: The modified quasi-emulsion solvent diffusion method was used to prepare microsponges. A 32 factorial design was employed to study the formulation and the effects of independent variables (volume of organic solvent and Eudragit-RS100 content) on dependent variables (particle size, %entrapment efficiency, and %cumulative drug release). The optimized microsponge (F4) was characterized by scanning electron microscopy, powder X-ray diffraction, and thermogravimetric analysis. F4 was plugged along with the calcium pectinate beads in HPMC capsules coated with enteric polymer Eudragit-L100 (Ed-L100) and/or Eudragit-S100 (Ed-S100) in different proportions. An in vitro release study of ECHC was performed in simulated gastric fluid for 2 h, followed by simulated intestinal fluid for next 6 h and then in simulated colonic fluid (in the presence and absence of pectinase enzyme for further 16 h). The optimized formulation was subjected to in vivo roentgenographic and pharmacokinetic studies in New Zealand white rabbits to analyze the in vivo behavior of the developed colon-targeted capsules. Results: Drug release was retarded on coating with Ed-S100 in comparison to a blend of Ed-S100:Ed-L100 coating. The percentage of 5-FU released at the end of 24 h from ECHC3 was 97.83 ± 0.12% in the presence of pectinase whereas in the control study, it was 40.08 ± 0.02%. Conclusion: Thus, enteric-coated HPMC capsules plugged with 5-FU-loaded microsponges and calcium pectinate beads proved to be a promising dosage form for colon targeting. PMID:26682194

  15. Optimization of antibacterial activity by Gold-Thread (Coptidis Rhizoma Franch) against Streptococcus mutans using evolutionary operation-factorial design technique.

    PubMed

    Choi, Ung-Kyu; Kim, Mi-Hyang; Lee, Nan-Hee

    2007-11-01

    This study was conducted to find the optimum extraction condition of Gold-Thread for antibacterial activity against Streptococcus mutans using The evolutionary operation-factorial design technique. Higher antibacterial activity was achieved in a higher extraction temperature (R2 = -0.79) and in a longer extraction time (R2 = -0.71). Antibacterial activity was not affected by differentiation of the ethanol concentration in the extraction solvent (R2 = -0.12). The maximum antibacterial activity of clove against S. mutans determined by the EVOP-factorial technique was obtained at 80 degrees C extraction temperature, 26 h extraction time, and 50% ethanol concentration. The population of S. mutans decreased from 6.110 logCFU/ml in the initial set to 4.125 logCFU/ml in the third set. PMID:18092475

  16. Muon Colliders and Neutrino Factories

    SciTech Connect

    Geer, Steve; /Fermilab

    2009-11-01

    Over the past decade, there has been significant progress in developing the concepts and technologies needed to produce, capture, and accelerate {Omicron}(10{sup 21}) muons per year. These developments have paved the way for a new type of neutrino source (neutrino factory) and a new type of very high energy lepton-antilepton collider (muon collider). This article reviews the motivation, design, and research and development for future neutrino factories and muon colliders.

  17. Muon colliders and neutrino factories

    SciTech Connect

    Geer, S.; /Fermilab

    2010-09-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture and accelerate {Omicron}(10{sup 21}) muons/year. This development prepares the way for a new type of neutrino source (Neutrino Factory) and a new type of very high energy lepton-antilepton collider (Muon Collider). This article reviews the motivation, design and R&D for Neutrino Factories and Muon Colliders.

  18. Muon Colliders and Neutrino Factories *

    NASA Astrophysics Data System (ADS)

    Geer, Steve

    2009-11-01

    Over the past decade, there has been significant progress in developing the concepts and technologies needed to produce, capture, and accelerate O(1021) muons per year. These developments have paved the way for a new type of neutrino source (neutrino factory) and a new type of very high energy lepton-antilepton collider (muon collider). This article reviews the motivation, design, and research and development for future neutrino factories and muon colliders.

  19. A Group-Based Mobile Application to Increase Adherence in Exercise and Nutrition Programs: A Factorial Design Feasibility Study

    PubMed Central

    Venkatakrishnan, Anusha; Youngblood, Gregory Michael; Ram, Ashwin; Pirolli, Peter

    2016-01-01

    Background Novel methods of promoting self-monitoring and social support are needed to ensure long-term maintenance of behavior change. In this paper, we directly investigate the effects of group support in an exercise and nutrition program delivered by an mHealth application called Fittle. Objective Our first specific study aim was to explore whether social support improved adherence in wellness programs. Our second specific study aim was to assess whether media types (ePaper vs mobile) were associated with different levels of compliance and adherence to wellness programs. The third aim was to assess whether the use of an mHealth application led to positive changes to participants’ eating behavior, physical activity, and stress level, compared to traditional paper-based programs. Methods A 2 × 2 (eg, Media: Mobile vs ePaper × Group Type: Team vs Solo) factorial design feasibility study was conducted. A sample of 124 volunteers who were interested in improving eating behavior, increasing physical activity, or reducing stress participated in this study. The study duration was 8 weeks. All groups were self-directed with no ongoing human input from the research team. Results Participants in ePaper conditions had higher attrition rates compared to participants in Mobile conditions, χ3 2=9.96, P=.02 (N=124). Participants in Mobile conditions reported their compliance with a much higher frequency closer to the time of challenge activity completion (2-sample Kolmogorov-Smirnov test comparing distributions was highly significant—KS=0.33, P<.001 [N=63]). Participants in ePaper conditions had a much higher frequency of guessing while reporting as compared with those in Mobile conditions—χ1 2=25.25, P<.001 (N=63). Together, these findings suggest that the mobile app allowed a more accurate method to report and track health behaviors over a longer period than traditional ePaper-based diaries or log books. There was a significant difference in the overall compliance

  20. AutoPyFactory: A Scalable Flexible Pilot Factory Implementation

    NASA Astrophysics Data System (ADS)

    Caballero, J.; Hover, J.; Love, P.; Stewart, G. A.

    2012-12-01

    The ATLAS experiment at the CERN LHC is one of the largest users of grid computing infrastructure, which is a central part of the experiment's computing operations. Considerable efforts have been made to use grid technology in the most efficient and effective way, including the use of a pilot job based workload management framework. In this model the experiment submits ‘pilot’ jobs to sites without payload. When these jobs begin to run they contact a central service to pick-up a real payload to execute. The first generation of pilot factories were usually specific to a single Virtual Organization (VO), and were bound to the particular architecture of that VO's distributed processing. A second generation provides factories which are more flexible, not tied to any particular VO, and provide new and improved features such as monitoring, logging, profiling, etc. In this paper we describe this key part of the ATLAS pilot architecture, a second generation pilot factory, AutoPyFactory. AutoPyFactory has a modular design and is highly configurable. It is able to send different types of pilots to sites and exploit different submission mechanisms and queue characteristics. It is tightly integrated with the PanDA job submission framework, coupling pilot flow to the amount of work the site has to run. It gathers information from many sources in order to correctly configure itself for a site and its decision logic can easily be updated. Integrated into AutoPyFactory is a flexible system for delivering both generic and specific job wrappers which can perform many useful actions before starting to run end-user scientific applications, e.g., validation of the middleware, node profiling and diagnostics, and monitoring. AutoPyFactory also has a robust monitoring system that has been invaluable in establishing a reliable pilot factory service for ATLAS.

  1. The Use of a Fractional Factorial Design to Determine the Factors That Impact 1,3-Propanediol Production from Glycerol by Halanaerobium hydrogeniformans.

    PubMed

    Kalia, Shivani; Trager, Jordan; Sitton, Oliver C; Mormile, Melanie R

    2016-01-01

    In recent years, biodiesel, a substitute for fossil fuels, has led to the excessive production of crude glycerol. The resulting crude glycerol can possess a high concentration of salts and an alkaline pH. Moreover, current crude glycerol purification methods are expensive, rendering this former commodity a waste product. However, Halanaerobium hydrogeniformans, a haloalkaliphilic bacterium, possesses the metabolic capability to convert glycerol into 1,3-propanediol, a valuable commodity compound, without the need for salt dilution or adjusting pH when grown on this waste. Experiments were performed with different combinations of 24 medium components to determine their impact on the production of 1,3-propanediol by using a fractional factorial design. Tested medium components were selected based on data from the organism's genome. Analysis of HPLC data revealed enhanced production of 1,3-propanediol with additional glycerol, pH, vitamin B12, ammonium ions, sodium sulfide, cysteine, iron, and cobalt. However, other selected components; nitrate ions, phosphate ions, sulfate ions, sodium:potassium ratio, chloride, calcium, magnesium, silicon, manganese, zinc, borate, nickel, molybdenum, tungstate, copper and aluminum, did not enhance 1,3-propanediol production. The use of a fractional factorial design enabled the quick and efficient assessment of the impact of 24 different medium components on 1,3-propanediol production from glycerol from a haloalkaliphilic bacterium. PMID:27556494

  2. Investigation of protocols to extraction and quantification of folates in vegetables matrices split into liquor and fiber fraction using factorial design.

    PubMed

    Prado de Paiva, Emmanuela; Anderson de Azevedo Filho, Clayton; Ferreira, Sabrina Gomes; Stamford, Tânia Lucia Montenegro; da Paixão, Jose Almiro

    2012-10-19

    The main protocols of extraction were investigated for the six folate forms in vegetable matrices, treated in two fractions, liquor and fiber. In a pilot study, it was used ammonium acetate added of 2-mercaptoetanol and ascorbic acid as extraction solution. The condition of use of protease and folate conjugase was evaluated, besides alternative treatments without enzyme use. Based on the results of this stage, it was built the factorial design 2(4), with three replications at the central point, using the following variables: temperature, time for reaction, molar concentration of the extraction solution and ratio sample/solution as independent variables and dependent variable, the amount of each folate form extracted as well as spectral and chromatographic parameters. In the pilot study it was verified that the enzyme use can cause an increase in the variability of the folate content, which enabled to build the factorial design without the enzyme use. The binomial time and temperature showed greatest impact on the extraction profile, besides high concentrations of ammonium acetate resulting in bifurcation of some peaks. 5-Methyltetrahydrofolate was extracted primordially in the liquor fraction, indicating that this treatment on the matrix provoked suitable extraction condition to this folate. PMID:22980643

  3. Use of evolutionary operation (EVOP) factorial design technique to develop a bioprocess using grease waste as a substrate for lipase production.

    PubMed

    Kumar, Sunil; Katiyar, Nitin; Ingle, Priyanka; Negi, Sangeeta

    2011-04-01

    The aim of the present work was to develop a bioprocess using EVOP-factorial design technique employing grease waste as a substrate for the production of lipase. A newly isolated fungal strain of Penicillium chrysogenum was explored for the fermentation process. Solid-state fermentation (SSF) was carried out using grease waste and Czapek-dox medium, supplemented with wheat bran. The yield of lipase was 38 U/ml when SSF was carried out at 32 °C for 8 days and grease:wheat bran:Czapek-dox media in 1:1:2 (w/w/v). Different physicochemical parameters affecting the production of lipase were optimized through evolutionary operation (EVOP) factorial design technique and after optimization yield was enhanced up to 46 U/ml at 30 °C, pH 7.0 with 1:1:2 (w/w/v) grease waste:wheat bran:Czapek-dox media. Industrial grease waste has never been reported before for the production of industrially important lipase enzyme. PMID:21292479

  4. Factorial design for multivariate optimization of an on-line preconcentration system for platinum determination by ultrasonic nebulization coupled to inductively coupled plasma optical emission spectrometry.

    PubMed

    Cerutti, S; Salonia, J A; Ferreira, S L C; Olsina, R A; Martinez, L D

    2004-07-01

    A system for on-line preconcentration and determination of platinum by ultrasonic nebulization (USN) coupled to inductively coupled plasma optical emission spectrometry (ICP-OES) was studied. It is based on the chemical sorption of platinum on a column packed with polyurethane foam loaded with thiocyanate reagent. The optimization step was carried out using two level full factorial design. Three variables (pH, loading flow rate (LFR) and eluent concentration) were regarded as factors in the optimization. Results of the two level factorial design 2(3) with three replicates of the central point for platinum preconcentration, based on the variance analysis (ANOVA), demonstrated that the factors and their interactions are not statistically significant. The proposed procedure allowed the determination of platinum with a detection limit of 0.28mugl(-1). The precision for 10 replicate determinations at 10.0mugl(-1) Pt level was 3.8% relative standard deviation (R.S.D.), calculated from the peak heights obtained. A total enhancement factor of 100 was obtained with respect to ICP-OES using pneumatic nebulization (10 for USN and 10 for preconcentration). A sampling frequency of 50 samples per hour was obtained. The effect of other ions in concentrations agreeing with water samples was studied. The addition/recovery experiments in the samples analyzed demonstrated the accuracy and applicability of the system developed for platinum determination in spiked water samples. PMID:18969536

  5. Study of Montmorillonite Clay for the Removal of Copper (II) by Adsorption: Full Factorial Design Approach and Cascade Forward Neural Network

    PubMed Central

    Turan, Nurdan Gamze; Ozgonenel, Okan

    2013-01-01

    An intensive study has been made of the removal efficiency of Cu(II) from industrial leachate by biosorption of montmorillonite. A 24 factorial design and cascade forward neural network (CFNN) were used to display the significant levels of the analyzed factors on the removal efficiency. The obtained model based on 24 factorial design was statistically tested using the well-known methods. The statistical analysis proves that the main effects of analyzed parameters were significant by an obtained linear model within a 95% confidence interval. The proposed CFNN model requires less experimental data and minimum calculations. Moreover, it is found to be cost-effective due to inherent advantages of its network structure. Optimization of the levels of the analyzed factors was achieved by minimizing adsorbent dosage and contact time, which were costly, and maximizing Cu(II) removal efficiency. The suggested optimum conditions are initial pH at 6, adsorbent dosage at 10 mg/L, and contact time at 10 min using raw montmorillonite with the Cu(II) removal of 80.7%. At the optimum values, removal efficiency was increased to 88.91% if the modified montmorillonite was used. PMID:24453833

  6. The Japanese Positron Factory

    NASA Astrophysics Data System (ADS)

    Okada, S.; Sunaga, H.; Kaneko, H.; Takizawa, H.; Kawasuso, A.; Yotsumoto, K.; Tanaka, R.

    1999-06-01

    The Positron Factory has been planned at Japan Atomic Energy Research Institute (JAERI). The factory is expected to produce linac-based monoenergetic positron beams having world-highest intensities of more than 1010e+/sec, which will be applied for R&D of materials science, biotechnology and basic physics & chemistry. In this article, results of the design studies are demonstrated for the following essential components of the facilities: 1) Conceptual design of a high-power electron linac with 100 MeV in beam energy and 100 kW in averaged beam power, 2) Performance tests of the RF window in the high-power klystron and of the electron beam window, 3) Development of a self-driven rotating electron-to-positron converter and the performance tests, 4) Proposal of multi-channel beam generation system for monoenergetic positrons, with a series of moderator assemblies based on a newly developed Monte Carlo simulation and the demonstrative experiment, 5) Proposal of highly efficient moderator structures, 6) Conceptual design of a local shield to suppress the surrounding radiation and activation levels.

  7. HIGHER LUMINOSITY B-FACTORIES

    SciTech Connect

    Seeman, John T

    2002-08-20

    The present B-factories PEP-II and KEKB have reached luminosities of 3-4 x 10{sup 33}/cm{sup 2}/s and delivered integrated luminosity at rates in excess of 4fb{sup -1} per month [1,2]. The recent turn on of these two B-Factories has shown that modern accelerator physics, design, and engineering can produce colliders that rapidly reach their design luminosities and deliver integrated luminosities capable of frontier particle physics discoveries. PEP-II and KEK-B with ongoing upgrade programs should reach luminosities of over 10{sup 34}/cm{sup 2}/s in a few years and with more aggressive improvements may reach luminosities of order 10{sup 35}/cm{sup 2}/s by the end of the decade. However, due to particle physics requirements, the next generation B-Factory may require significantly more luminosity. Initial parameters of a very high luminosity e{sup +}e{sup -} B-Factory or Super B-Factory (SBF) are being developed incorporating several new ideas from the successful operation of the present generation e{sup +}e{sup -} accelerators [3,4]. A luminosity approaching 10{sup 36}/cm{sup 2}/s{sup -1} appears possible. Furthermore, the ratio of average to peak luminosity may be increased by 30% due to continuous injection. The operation of this accelerator will be qualitatively different from present e{sup +}e{sup -} colliders due to this continuous injection.

  8. Looking for Exotica at the B Factories

    SciTech Connect

    Mohanty, Gagan B.; ,

    2007-01-25

    Current experiments at the B factories, designed to perform precision measurements of matter-antimatter asymmetry in the B meson system, have a much broader physics reach especially in the sector of quarkonium spectroscopy. Here we present a minireview on the new charmonium-like states observed at the B factories including the X(3872) and Y(4260).

  9. [ital CPT], strings, and meson factories

    SciTech Connect

    Kostelecky, V.A. ); Potting, R. )

    1995-04-01

    Spontaneous breaking of [ital CPT] is possible in string theory. We show that it can arise at a level within reach of experiments at meson factories currently being built or designed. For [phi], [ital B], and [tau]-charm factories, we discuss the likely experimental string signatures and provide estimates of the bounds that might be attained in these machines.

  10. Polymeric nanoparticles loaded with the 3,5,3′-triiodothyroacetic acid (Triac), a thyroid hormone: factorial design, characterization, and release kinetics

    PubMed Central

    dos Santos, Karen C; da Silva, Maria Fatima GF; Pereira-Filho, Edenir R; Fernandes, Joao B; Polikarpov, Igor; Forim, Moacir R

    2012-01-01

    This present investigation deals with the development and optimization of polymeric nanoparticle systems loaded with 3,5,3′-triiodothyroacetic acid (Triac). A 211–6 fractional factorial design and another 22 factorial design were used to study the contrasts on particle size distribution, morphology, surface charge, drug content, entrapment efficiency, and in vitro drug release profiles. The independent variables were the concentration of Triac, type and quantity of both polymer and oil, quantity of Span™ 60 and Tween® 80, volume of solvent and water, and velocity of both magnetic stirring and the transfer of the organic phase into the aqueous solution. The results of optimized formulations showed a narrow size distribution with a polydispersity index lower than 0.200. The particle sizes were on average 159.6 nm and 285.6 nm for nanospheres and nanocapsules, respectively. The zeta potential was higher than 20 mV (in module) and the entrapment efficiency was nearly 100%. A high-performance liquid chromatography method was developed, validated, and efficiently applied to Triac quantification in colloidal suspension. The main independent variables were the type and quantity of the polymer and oil. In vitro drug release profile depicted several features to sustain Triac release. Different formulations showed various release rates indicating an interaction between Triac and other formulation compounds such as polymer and/or oil quantity. Two different models were identified (biexponential and monoexponential) that allowed the control of both the release rate and Triac concentration. Thus, the prepared nanoparticles described here may be of clinical importance in delivering Triac for thyroid treatment. PMID:24198495

  11. Influence of the Formulation Parameters on the Particle Size and Encapsulation Efficiency of Resveratrol in PLA and PLA-PEG Blend Nanoparticles: A Factorial Design.

    PubMed

    Lindner, Gabriela da Rocha; Dalmolin, Luciana Facco; Khalil, Najeh Maissar; Mainardes, Rubiana Mara

    2015-12-01

    Polymeric nanoparticles are colloidal systems that promote protection and modification of physicochemical characteristics of a drug and that also ensure controlled and extended drug release. This paper reports a 2(3) factorial design study to optimize poly(lactide) (PLA) and poly(lactide)-polyethylene glycol (PLA-PEG) blend nanoparticles containing resveratrol (RVT) for prolonged release. The independent variables analyzed were solvent composition, surfactant concentration and ratio of aqueous to organic phase (two levels each factor). Mean particle size and RVT encapsulation efficiency were set as the dependent variables. The selected optimized parameters were set as organic phase comprised of a mixture of dichloromethane and ethyl acetate, 1% of surfactant polyvinyl alcohol and a 3:1 ratio of aqueous to organic phase, for both PLA and PLA-PEG blend nanoparticles. This formulation originated nanoparticles with size of 228 ± 10 nm and 185 ± 70 nm and RVT encapsulation efficiency of 82 ± 10% and 76 ± 7% for PLA and PLA-PEG blend nanoparticles, respectively. The in vitro release study showed a biphasic pattern with prolonged RVT release and PEG did not influence the RVT release. The in vitro release data were in favor of Higuchi-diffusion kinetics for both nanoformulations and the Kossmeyer-Peppas coefficient indicated that anomalous transport was the main release mechanism of RVT. PLA and PLA-PEG blend nanoparticles produced with single emulsion-solvent evaporation technology were found to be a promising approach for the incorporation of RVT and promoted its controlled release. The factorial design is a tool of great value in choosing formulations with optimized parameters. PMID:26682464

  12. The Low Energy Neutrino Factory

    SciTech Connect

    Bross, Alan; Geer, Steve; Ellis, Malcolm; Fernandez Martinez, Enrique; Li, Tracey; Pascoli, Silvia; Mena, Olga

    2010-03-30

    We show that a low energy neutrino factory with a baseline of 1300 km and muon energy of 4.5 GeV has an excellent physics reach. The results of our optimisation studies demonstrate that such a setup can have remarkable sensitivity to theta{sub 13} and delta for sin{sup 2}(2theta{sub 13})>10{sup -4}, and to the mass hierarchy for sin{sup 2}(2theta{sub 13})>10{sup -3}. We also illustrate the power of the unique combination of golden and platinum channels accessible to the low energy neutrino factory. We have considered both a 20 kton totally active scintillating detector and a 100 kton liquid argon detector as possible detector technologies, finding that a liquid argon detector with very good background rejection can produce sensitivity to theta{sub 13} and delta with that of the International Design Study neutrino factory.

  13. Factory Cost Model

    1996-12-17

    The Factory Cost Model (FCM) is an economic analysis tool intended to provide flat panel display (FPD) and other similar discrete component manufacturers with the ability to make first-order estimates of the cost of unit production. This software has several intended uses. Primary among these is the ability to provide first-order economic analysis for future factories. Consequently, the model requires a minimal level of input detail, and accomodates situations where actual production data are notmore » available. This software is designed to be activity based such that most of the calculated direct costs are associated with the steps of a manufacturibg process. The FCM architecture has the ability to accomodate the analysis of existing manufacturing facilities. The FCM can provide assistance with strategic economic decisions surrounding production related matters. For instance, the program can project the effect on costs and resources of a new product''s introduction, or it can assess the potential cost reduction produced by step yield improvements in the manufacturing process.« less

  14. The Walking Interventions Through Texting (WalkIT) Trial: Rationale, Design, and Protocol for a Factorial Randomized Controlled Trial of Adaptive Interventions for Overweight and Obese, Inactive Adults

    PubMed Central

    Hurley, Jane C; Hollingshead, Kevin E; Todd, Michael; Jarrett, Catherine L; Tucker, Wesley J; Angadi, Siddhartha S

    2015-01-01

    active and are overweight or obese. WalkIT is one of the first studies focusing on the individual components of combined goal setting and reward structures in a factorial design to increase walking. The trial is expected to produce results useful to future research interventions and perhaps industry initiatives, primarily focused on mHealth, goal setting, and those looking to promote behavior change through performance-based incentives. Trial Registration ClinicalTrials.gov NCT02053259; https://clinicaltrials.gov/ct2/show/NCT02053259 (Archived by WebCite at http://www.webcitation.org/6b65xLvmg). PMID:26362511

  15. Charged Particle Optics in Circular Higgs Factory

    SciTech Connect

    Cai, Yunhai

    2015-02-26

    Similar to a super B-factory, a circular Higgs factory will require strong focusing systems near the interaction points and a low-emittance lattice in arcs to achieve a factory luminosity. At electron beam energy of 120 GeV, beamstrahlung effects during the collision pose an additional challenge to the collider design. In particular, a large momentum acceptance at 2 percent level is necessary to retain an adequate beam lifetime. This turns out to be the most challenging aspect in the design of circular Higgs factory. In this paper, an example will be provided to illustrate the beam dynamics in circular Higgs factory, emphasizing on the chromatic optics. Basic optical modules and advanced analysis will be presented. Most important, we will show that 2% momentum aperture is achievable

  16. Investigation on gamma-ray position sensitivity at 662 keV in a spectroscopic 3' x 3' LaBr3:Ce scintillator

    NASA Astrophysics Data System (ADS)

    Giaz, A.; Camera, F.; Birocchi, F.; Blasi, N.; Boiano, C.; Brambilla, S.; Coelli, S.; Fiorini, C.; Marone, A.; Million, B.; Riboldi, S.; Wieland, O.

    2015-02-01

    The position sensitivity of a thick, cylindrical and continuous 3" x 3" (7.62 cm x 7.62 cm) LaBr3:Ce crystal was studied using a 1 mm collimated beam of 662 keV gamma rays from a 400 MBq intense 137Cs source and a spectroscopic photomultiplier (PMT) (HAMAMATSU R6233-100SEL). The PMT entrance window was covered by black absorber except for a small window 1 cm x 1 cm wide. A complete scan of the detector over a 0.5 cm step grid was performed for three positions of the 1 cm x 1 cm window. For each configuration the energy spectrum was measured and the peak centroid, the FWHM, the area and peak asymmetry of the 662 keV gamma transition were analyzed. The data show that, even in a 3" thick LaBr3:Ce crystal with diffusive surfaces the position of the full energy peak centroid depends on the source position. We verified that, on average, the position of the full energy peak centroids measured in the three 1 cm x 1 cm window configurations is sufficient for the correct identification of the collimated gamma source position.

  17. NUCLEAR ENERGY RESEARCH INITIATIVE (NERI) PROGRAM GRANT NUMBER DE-FG03-00SF22168 TECHNICAL PROGRESS REPORT (Nov. 15, 2001 - Feb. 15,2002) ''Design and Layout Concepts for Compact, Factory-Produced, Transportable, Generation IV Reactor Systems''

    SciTech Connect

    Fred R. Mynatt; Andy Kadak; Marc Berte; Larry Miller; Mohammed Khan; Joe McConn; Lawrence Townsend; Wesley Williams; Martin Williamson

    2002-03-15

    The objectives of this project are to develop and evaluate nuclear power plant designs and layout concepts to maximize the benefits of compact modular Generation IV reactor concepts including factory fabrication and packaging for optimal transportation and siting. Three nuclear power plant concepts are being studied representing water, helium and lead-bismuth coolants. This is the sixth quarterly progress report.

  18. Virtual patients design and its effect on clinical reasoning and student experience: a protocol for a randomised factorial multi-centre study

    PubMed Central

    2012-01-01

    Background Virtual Patients (VPs) are web-based representations of realistic clinical cases. They are proposed as being an optimal method for teaching clinical reasoning skills. International standards exist which define precisely what constitutes a VP. There are multiple design possibilities for VPs, however there is little formal evidence to support individual design features. The purpose of this trial is to explore the effect of two different potentially important design features on clinical reasoning skills and the student experience. These are the branching case pathways (present or absent) and structured clinical reasoning feedback (present or absent). Methods/Design This is a multi-centre randomised 2x2 factorial design study evaluating two independent variables of VP design, branching (present or absent), and structured clinical reasoning feedback (present or absent).The study will be carried out in medical student volunteers in one year group from three university medical schools in the United Kingdom, Warwick, Keele and Birmingham. There are four core musculoskeletal topics. Each case can be designed in four different ways, equating to 16 VPs required for the research. Students will be randomised to four groups, completing the four VP topics in the same order, but with each group exposed to a different VP design sequentially. All students will be exposed to the four designs. Primary outcomes are performance for each case design in a standardized fifteen item clinical reasoning assessment, integrated into each VP, which is identical for each topic. Additionally a 15-item self-reported evaluation is completed for each VP, based on a widely used EViP tool. Student patterns of use of the VPs will be recorded. In one centre, formative clinical and examination performance will be recorded, along with a self reported pre and post-intervention reasoning score, the DTI. Our power calculations indicate a sample size of 112 is required for both primary outcomes

  19. Determination of nickel in food samples by flame atomic absorption spectroscopy after preconcentration and microextraction based ionic liquids using full factorial and central composite design.

    PubMed

    Zarei, Zohre; Shemirani, Farzaneh

    2012-12-01

    In this research, a microextraction technique based on ionic liquids (ILs) termed in situ solvent formation microextraction (ISFME) was used for determination of nickel in solutions. 1-(2-pyridylazo)-2-naphtol (PAN) was chosen as a complexing agent. After preconcentration, the settled IL-phase was dissolved in 50 μL of ethanol and aspirated into the flame atomic absorption spectrometer (FAAS) using a home-made microsample introduction system. Injection of 50 μL volumes of analyte into an air-acetylene flame provided very sensitive spike-like and reproducible signals. ISFME is based on phase separation phenomenon of ionic liquids in aqueous solutions. This method is simple and rapid for extraction and preconcentration of metal ions from food samples and can be applied for the sample solutions containing very high concentrations of salt. Furthermore, this technique is much safer in comparison with the organic solvent extraction because of using ionic liquid. The effective parameters such as amount of IL, salt effect, concentration of the chelating agent and ion pairing agent were inspected by a full factorial design to identify important parameters and their interactions. Next, a central composite design was applied to obtain optimum point of the important parameters. Under the optimum conditions, the calibration graph was linear over the range of 2 to 80 ng/mL. The limit of detection and relative standard deviation (n= 6) were 0.6 ng/mL and 2%, respectively. PMID:22853633

  20. Factorial design optimization and characterization of poly-lactic acid (PLA) nanoparticle formation for the delivery of grape extracts.

    PubMed

    Fernández, Katherina; Aburto, Javiera; von Plessing, Carlos; Rockel, Marlene; Aspé, Estrella

    2016-09-15

    Proanthocyanidins (PAs) extracted from grapes have several bioactive properties, giving them potential medical uses. However, PAs are unstable in the digestive tract and must be stabilized to allow oral administration, which can be accomplished by nanoencapsulation. In this study, PAs extracted from grape seed and skin were stabilized with poly-d,l-lactide (PLA) polymer by the emulsion-evaporation method. An experimental Box-Behnken design was implemented, evaluating the influence of three factors: sonication time (30-360s) for the emulsion formation, loading of grape extracts (5-20%) and concentration of stabilizing agent (polyvinyl alcohol, PVA: 1-3%). The process was optimized to achieve higher encapsulation efficiency (EE=82.7%) and a smaller size (256 nm). The nanoparticles (NPs) were physically analyzed by TEM, FT-IR, TGA and DTG to characterize the nanoencapsulation process. In vitro release studies, through stomach and intestinal simulation, showed a sustained release of PAs from PLA-NPs. PMID:27080882

  1. Optimization of headspace solid-phase microextraction for the analysis of specific flavors in enzyme modified and natural Cheddar cheese using factorial design and response surface methodology.

    PubMed

    Januszkiewicz, Julien; Sabik, Hassan; Azarnia, Sorayya; Lee, Byong

    2008-06-27

    A headspace solid-phase microextraction (HS-SPME) combined with gas chromatography-mass spectrometry (GC/MS) method was developed using experimental designs to quantify the flavor of commercial Cheddar cheese and enzyme-modified Cheddar cheese (EMCC). Seven target compounds (dimethyl disulfide, hexanal, hexanol, 2-heptanone, ethyl hexanoate, heptanoic acid, delta-decalactone) representative of different chemical families frequently present in Cheddar cheese were selected for this study. Three types of SPME fibres were tested: Carboxen/polydimethylsiloxane (CAR/PDMS), polyacrylate (PA) and Carbowax/divinylbenzene (CW/DVB). NaCl concentration and temperature, as well as extraction time were tested for their effect on the HS-SPME process. Two series of two-level full factorial designs were carried out for each fibre to determine the factors which best support the extraction of target flavors. Therefore, central composite designs (CCDs) were performed and response surface models were derived. Optimal extraction conditions for all selected compounds, including internal standards, were: 50 min at 55 degrees C in 3M NaCl for CAR/PDMS, 64 min at 62 degrees C in 6M NaCl for PA, and 37 min at 67 degrees C in 6M NaCl for CW/DVB. Given its superior sensitivity, CAR/PDMS fibre was selected to evaluate the target analytes in commercial Cheddar cheese and EMCC. With this fibre, calibration curves were linear for all targeted compounds (from 0.5 to 6 microg g(-1)), except for heptanoic acid which only showed a linear response with PA fibres. Detection limits ranged from 0.3 to 1.6 microg g(-1) and quantification limits from 0.8 to 3.6 microg g(-1). The mean repeatability value for all flavor compounds was 8.8%. The method accuracy is satisfactory with recoveries ranging from 97 to 109%. Six of the targeted flavors were detected in commercial Cheddar cheese and EMCC. PMID:18495140

  2. Quantitative and qualitative optimization of allergen extraction from peanut and selected tree nuts. Part 2. Optimization of buffer and ionic strength using a full factorial experimental design.

    PubMed

    L'Hocine, Lamia; Pitre, Mélanie

    2016-03-01

    A full factorial design was used to assess the single and interactive effects of three non-denaturing aqueous (phosphate, borate, and carbonate) buffers at various ionic strengths (I) on allergen extractability from and immunoglobulin E (IgE) immunoreactivity of peanut, almond, hazelnut, and pistachio. The results indicated that the type and ionic strength of the buffer had different effects on protein recovery from the nuts under study. Substantial differences in protein profiles, abundance, and IgE-binding intensity with different combinations of pH and ionic strength were found. A significant interaction between pH and ionic strength was observed for pistachio and almond. The optimal buffer system conditions, which maximized the IgE-binding efficiency of allergens and provided satisfactory to superior protein recovery yield and profiles, were carbonate buffer at an ionic strength of I=0.075 for peanut, carbonate buffer at I=0.15 for almond, phosphate buffer at I=0.5 for hazelnut, and borate at I=0.15 for pistachio. The buffer type and its ionic strength could be manipulated to achieve the selective solubility of desired allergens. PMID:26471623

  3. Adsorption of Disperse Orange 30 dye onto activated carbon derived from Holm Oak (Quercus Ilex) acorns: A 3(k) factorial design and analysis.

    PubMed

    Tezcan Un, Umran; Ates, Funda; Erginel, Nihal; Ozcan, Oznur; Oduncu, Emre

    2015-05-15

    In this study, samples of activated carbon were prepared from Holm Oak acorns by chemical activation with H3PO4, ZnCl2 and KOH as activating agents. The samples were characterized by SEM, BET, FTIR and elemental analysis, and were then evaluated for the removal of Disperse Orange 30 (DO30) dyes from aqueous solutions. A 3(k) factorial design was used to determine the interaction effects of carbonization temperature, pH, dosage of adsorbent and type of activating agent on the amount of dye removal. Also, level of effectiveness factors were determined by conducting regression models for maximum adsorption efficiency. Of all the samples, the sample generated using ZnCl2 as an activating agent showed a maximum dye removal efficiency of 93.5% at a carbonization temperature of 750 °C, a pH of 2 and an adsorbent dosage of 0.15 g/25 ml. The analysis shows that the adsorption process depends significantly on the type of activating agent used in the preparation of activated carbon. PMID:25776797

  4. Optimization of promethazine theoclate fast dissolving tablet using pore forming technology by 3-factor, 3-level response surface-full factorial design.

    PubMed

    Sharma, Shailesh; Sharma, Neelam; Das Gupta, Ghanshyam

    2010-08-01

    The present research work was undertaken to optimize and formulate Promethazine Theoclate as a fast dissolving tablet using pore forming technology that disintegrates or dissolves rapidly and offer a suitable approach for the treatment of nausea and vomiting. Fast dissolving tablets of Promethazine Theoclate was prepared by increasing the solubility i.e. using beta-cyclodextrin, crospovidone, and menthol. A 3(3) full factorial design was employed to investigate the combined influence of these three independent variables, i.e., amount of menthol, crospovidone and beta-cyclodextrin on disintegration time, percentage friability and percentage drug release after 5 min. In the optimization study, multiple regression analysis has revealed that an optimum amount of menthol, crospovidone and beta-cyclodextrin gives a rapidly disintegrating/dissolving tablet. In order to prove the validity of the evolved mathematical model a checkpoint batch was also prepared. Optimized tablets were prepared with an optimum amount of beta-cyclodextrin, menthol and crospovidone which disintegrated in the 30 s, having friability 0.599% and released drug 89% after 5 min. PMID:20803123

  5. Lipase-catalyzed acidolysis of tripalmitin with capric acid in organic solvent medium: Analysis of the effect of experimental conditions through factorial design and analysis of multiple responses.

    PubMed

    Foresti, María Laura; Ferreira, María Luján

    2010-05-01

    The acidolysis of tripalmitin with capric acid catalyzed by an immobilized form of a 1,3-positionally selective lipase (Rhizomucor miehei) showed to be effective for the synthesis of structured lipids of the MLL and MLM type. The effects that reaction parameters such as substrate molar ratio (N), biocatalyst load (E), and reaction temperature (T) have on selected responses variables (i.e. total conversion of tripalmitin, selectivity and yield of the desired structured lipid, hydrolysis yield, and acyl migration importance), were evaluated by use of an experimental factorial design of three factors and three levels with two central points and with a confidence level of 95%. The range of each parameter was selected as follows: N=3-9, E=5-15wt%, T=50-70°C. The statistical analysis of results was addressed by use of both simple linear models and more complicated quadratic models using specific commercial software. The results obtained showed that a proper selection of reaction conditions is needed in order to maximize not only the yield of the desired structured lipid, but also to minimize the generation of hydrolysis and acyl migration by-products. PMID:25919616

  6. Formulation and optimization of coated PLGA – Zidovudine nanoparticles using factorial design and in vitro in vivo evaluations to determine brain targeting efficiency

    PubMed Central

    Peter Christoper, G.V.; Vijaya Raghavan, C.; Siddharth, K.; Siva Selva Kumar, M.; Hari Prasad, R.

    2013-01-01

    In the current study zidovudine loaded PLGA nanoparticles were prepared, coated and further investigated for its effectiveness in brain targeting. IR and DSC studies were performed to determine the interaction between excipients used and to find out the nature of drug in the formulation. Formulations were prepared by adopting 23 factorial designs to evaluate the effects of process and formulation variables. The prepared formulations were subjected for in vitro and in vivo evaluations. In vitro evaluations showed particle size below 100 nm, entrapment efficiency of formulations ranges of 28–57%, process yield of 60–76% was achieved and drug release for the formulations were in the range of 50–85%. The drug release from the formulations was found to follow Higuchi release pattern, n–value obtained after Korsemeyer plot was in the range of 0.56–0.78. In vivo evaluations were performed in mice after intraperitoneal administration of zidovudine drug solution, uncoated and coated formulation. Formulation when coated with Tween 80 achieved a higher concentration in the brain than that of the drug in solution and of the uncoated formulation. Stability studies indicated that there was no degradation of the drug in the formulation after 90 days of preparation when stored in refrigerated condition. PMID:24648825

  7. Effect of process variables on the sulfate reduction process in bioreactors treating metal-containing wastewaters: factorial design and response surface analyses.

    PubMed

    Villa-Gomez, D K; Pakshirajan, K; Maestro, R; Mushi, S; Lens, P N L

    2015-07-01

    The individual and combined effect of the pH, chemical oxygen demand (COD) and SO4 (2-) concentration, metal to sulfide (M/S(2-)) ratio and hydraulic retention time (HRT) on the biological sulfate reduction (SR) process was evaluated in an inverse fluidized bed reactor by factorial design analysis (FDA) and response surface analysis (RSA). The regression-based model of the FDA described the experimental results well and revealed that the most significant variable affecting the process was the pH. The combined effect of the pH and HRT was barely observable, while the pH and COD concentration positive effect (up to 7 and 3 gCOD/L, respectively) enhanced the SR process. Contrary, the individual COD concentration effect only enhanced the COD removal efficiency, suggesting changes in the microbial pathway. The RSA showed that the M/S(2-) ratio determined whether the inhibition mechanism to the SR process was due to the presence of free metals or precipitated metal sulfides. PMID:26071684

  8. Factorial design analysis of the effects of wave function modifications on calculated HC and CC stretching frequencies in H 2C dbnd CHX and HC tbnd CX

    NASA Astrophysics Data System (ADS)

    Ramos, Mozart N.; Lopes, Kelson C.; Rusu, Victor H.; Araújo, Regiane C. M. U.

    2009-04-01

    Two-level factorial designs (FD) have been used to determine the effects of wave function modifications on calculated CH and CC harmonic stretching frequencies of the H 2C dbnd CHX and HC tbnd CX molecules with X = H, CH 3, F, Cl and CN. These modifications were treated at two levels, which consists in: (I) using either a double- or a triple-zeta valence basis set; (II) including or not diffuse functions in basis set, (III) including or not polarization functions in basis set, and (IV) performing a calculation with or without electron correlation beyond the Hartree-Fock level, i.e., MP2 or B3LYP. Our results have shown that valence (Val), diffuse (Dif), polarization (Pol) and electron correlation (Corr) main effects as well as the Pol/Corr second-order interaction effect are significant to build factorial models for these vibrational modes. When valence and diffuse functions are introduced in the basis set, the calculated HC and CC stretching frequencies are decreased in both the HC tbnd CX and H 2C dbnd CHX molecules. As expected, by far the correlation principal effect is the most important on the frequency values. This effect provokes a decrease of -281.4 cm -1 and -153.3 cm -1 in the C tbnd C and C dbnd C vibrational frequencies, respectively, using the MP2 calculations, whereas this decrease for the H sbnd C oscillator is -156.1 cm -1 and -116.1 cm -1 in HC tbnd CX and H 2C dbnd CHX, respectively. This same effect produces an important Pol/Corr interaction effect on HC and CC stretching frequencies, increasing their values by +45.3 cm -1 and +18.4 cm -1 in HC tbnd CX, respectively, whereas their corresponding values in H 2C dbnd CHX are +43.9 cm -1 and +11.0 cm -1, respectively. Finally, algebraic models were then established to explain how calculated HC and CC stretching frequencies in HC tbnd CX and H 2C dbnd CHX depend on the characteristics of the molecular orbital wave functions.

  9. Evaluation and simultaneous optimization of bio-hydrogen production using 3 2 factorial design and the desirability function

    NASA Astrophysics Data System (ADS)

    Cuetos, M. J.; Gómez, X.; Escapa, A.; Morán, A.

    Various mixtures incorporating a simulated organic fraction of municipal solid wastes and blood from a poultry slaughterhouse were used as substrate in a dark fermentation process for the production of hydrogen. The individual and interactive effects of hydraulic retention time (HRT), solid content in the feed (%TS) and proportion of residues (%Blood) on bio-hydrogen production were studied in this work. A central composite design and response surface methodology were employed to determine the optimum conditions for the hydrogen production process. Experimental results were approximated to a second-order model with the principal effects of the three factors considered being statistically significant (P < 0.05). The production of hydrogen obtained from the experimental point at conditions close to best operability was 0.97 L Lr -1 day -1. Moreover, a desirability function was employed in order to optimize the process when a second, methanogenic, phase is coupled with it. In this last case, the optimum conditions lead to a reduction in the production of hydrogen when the optimization process involves the maximization of intermediary products.

  10. Factorial-design optimization of gas chromatographic analysis of tetrabrominated to decabrominated diphenyl ethers. Application to domestic dust.

    PubMed

    Regueiro, Jorge; Llompart, Maria; Garcia-Jares, Carmen; Cela, Rafael

    2007-07-01

    Gas chromatographic analysis of polybrominated diphenyl ethers (PBDEs) has been evaluated in an attempt to achieve better control of the separation process, especially for highly substituted congeners. Use of a narrow-bore capillary column enabled adequate determination of tetra, penta, hexa, hepta, octa, nona and decaBDE congeners in only one chromatographic run while maintaining resolution power similar to that of conventional columns. A micro electron-capture detector (GC-microECD) was used. Chromatographic conditions were optimized by multifactorial experimental design, with the objective of obtaining not only high sensitivity but also good precision. In this way two different approaches to maximizing response and minimizing variability were tested, and are fully discussed. These optimum chromatographic conditions were then used to determine PBDEs extracted from domestic dust samples by microwave-assisted solvent extraction (MASE). Quantitative recovery (90-108%) was achieved for all the PBDEs and method precision (RSD < 13%) was satisfactory. Accuracy was tested by use of the standard reference material SRM 2585, and sub-ng g(-1) limits of detection were obtained for all compounds except BDE-209 (1.44 ng g(-1)). Finally, several samples of house dust were analysed by use of the proposed method and all the target PBDEs were detected in all the samples. BDE-209 was the predominant congener. Amounts varied from 58 to 1615 ng g(-1) and the average contribution to the total PBDE burden of 52%. The main congeners of the octaBDE mixture (BDE-183, BDE-197, BDE-207 and BDE-196) also made an important contribution (29%) to the total. These are the first data about the presence of these compounds in European house-dust samples. Finally, the sum of the main congeners in the pentaBDE commercial mixture (BDE-47, BDE-99, and BDE-100) contributed 14% to the total. Figure Polybrominated diphenyl ethers in House Dust. PMID:17541561

  11. NEUTRINO FACTORIES - PHYSICS POTENTIALS.

    SciTech Connect

    PARSA,Z.

    2001-02-16

    The recent results from Super-Kamiokande atmospheric and solar neutrino observations opens a new era in neutrino physics and has sparked a considerable interest in the physics possibilities with a Neutrino Factory based on the muon storage ring. We present physics opportunities at a Neutrino Factory, and prospects of Neutrino oscillation experiments. Using the precisely known flavor composition of the beam, one could envision an extensive program to measure the neutrino oscillation mixing matrix, including possible CP violating effects. These and Neutrino Interaction Rates for examples of a Neutrino Factory at BNL (and FNAL) with detectors at Gran Sasso, SLAC and Sudan are also presented.

  12. Photon collider Higgs factories

    NASA Astrophysics Data System (ADS)

    Telnov, V. I.

    2014-09-01

    The discovery of the Higgs boson (and still nothing else) have triggered appearance of many proposals of Higgs factories for precision measurement of the Higgs properties. Among them there are several projects of photon colliders (PC) without e+e- in addition to PLC based on e+e- linear colliders ILC and CLIC. In this paper, following a brief discussion of Higgs factories physics program I give an overview of photon colliders based on linear colliders ILC and CLIC, and of the recently proposed photon-collider Higgs factories with no e+e- collision option based on recirculation linacs in ring tunnels.

  13. Neutrino factories: realization and physics potential

    SciTech Connect

    Geer, S.; Zisman, M.S.; /LBL, Berkeley

    2006-12-01

    Neutrino Factories offer an exciting option for the long-term neutrino physics program. This new type of neutrino facility will provide beams with unique properties. Low systematic uncertainties at a Neutrino Factory, together with a unique and precisely known neutrino flavor content, will enable neutrino oscillation measurements to be made with unprecedented sensitivity and precision. Over recent years, the resulting neutrino factory physics potential has been discussed extensively in the literature. In addition, over the last six years the R&D necessary to realize a Neutrino Factory has been progressing, and has developed into a significant international activity. It is expected that, within about five more years, the initial phase of this R&D program will be complete and, if the community chooses to build this new type of neutrino source within the following decade, neutrino factory technology will be ready for the final R&D phase prior to construction. In this paper (1) an overview is given of the technical ingredients needed for a Neutrino Factory, (2) beam properties are described, (3) the resulting neutrino oscillation physics potential is summarized, (4) a more detailed description is given for one representative Neutrino Factory design, and (5) the ongoing R&D program is summarized, and future plans briefly described.

  14. Manning the Unmanned Factory.

    ERIC Educational Resources Information Center

    Ebel, Karl-H.

    1989-01-01

    Suggests that total factory integration through computer networks, even when technically feasible, might be unwieldy, inefficient, and uneconomical because the human factor and accumulated know-how of the work force tend to be overlooked. (Author/JOW)

  15. The nearby supernova factory

    SciTech Connect

    Wood-Vasey, W.M.; Aldering, G.; Lee, B.C.; Loken, S.; Nugent, P.; Perlmutter, S.; Siegrist, J.; Wang, L.; Antilogus, P.; Astier, P.; Hardin, D.; Pain, R.; Copin, Y.; Smadja, G.; Gangler, E.; Castera, A.; Adam, G.; Bacon, R.; Lemonnier, J.-P.; Pecontal, A.; Pecontal, E.; Kessler, R.

    2004-01-23

    The Nearby Supernova Factory (SNfactory) is an ambitious project to find and study in detail approximately 300 nearby Type Ia supernovae (SNe Ia) at redshifts 0.03 < z < 0.08. This program will provide an exceptional data set of well-studied SNe in the nearby smooth Hubble flow that can be used as calibration for the current and future programs designed to use SNe to measure the cosmological parameters. The first key ingredient for this program is a reliable supply of Hubble-flow SNe systematically discovered in unprecedented numbers using the same techniques as those used in distant SNe searches. In 2002, 35 SNe were found using our test-bed pipeline for automated SN search and discovery. The pipeline uses images from the asteroid search conducted by the Near Earth Asteroid Tracking group at JPL. Improvements in our subtraction techniques and analysis have allowed us to increase our effective SN discovery rate to {approx}12 SNe/month in 2003.

  16. MUON STORAGE RINGS - NEUTRINO FACTORIES

    SciTech Connect

    PARSA,Z.

    2000-05-30

    The concept of a muon storage ring based Neutrino Source (Neutrino Factory) has sparked considerable interest in the High Energy Physics community. Besides providing a first phase of a muon collider facility, it would generate more intense and well collimated neutrino beams than currently available. The BNL-AGS or some other proton driver would provide an intense proton beam that hits a target, produces pions that decay into muons. The muons must be cooled, accelerated and injected into a storage ring with a long straight section where they decay. The decays occurring in the straight sections of the ring would generate neutrino beams that could be directed to detectors located thousands of kilometers away, allowing studies of neutrino oscillations with precisions not currently accessible. For example, with the neutrino source at BNL, detectors at Soudan, Minnesota (1,715 km), and Gran Sasso, Italy (6,527 km) become very interesting possibilities. The feasibility of constructing and operating such a muon-storage-ring based Neutrino-Factory, including geotechnical questions related to building non-planar storage rings (e.g. at 8{degree} angle for BNL-Soudan, and 3{degree} angle for BNL-Gran Sasso) along with the design of the muon capture, cooling, acceleration, and storage ring for such a facility is being explored by the growing Neutrino Factory and Muon Collider Collaboration (NFMCC). The authors present overview of Neutrino Factory concept based on a muon storage ring, its components, physics opportunities, possible upgrade to a full muon collider, latest simulations of front-end, and a new bowtie-muon storage ring design.

  17. Gellan gum-based mucoadhesive microspheres of almotriptan for nasal administration: Formulation optimization using factorial design, characterization, and in vitro evaluation

    PubMed Central

    Abbas, Zaheer; Marihal, Sachin

    2014-01-01

    Background: Almotriptan malate (ALM), indicated for the treatment of migraine in adults is not a drug candidate feasible to be administered through the oral route during the attack due to its associated symptoms such as nausea and vomiting. This obviates an alternative dosage form and nasal drug delivery is a good substitute to oral and parenteral administration. Materials and Methods: Gellan gum (GG) microspheres of ALM, for intranasal administration were prepared by water-in-oil emulsification cross-linking technique employing a 23 factorial design. Drug to polymer ratio, calcium chloride concentration and cross-linking time were selected as independent variables, while particle size and in vitro mucoadhesion of the microspheres were investigated as dependent variables. Regression analysis was performed to identify the best formulation conditions. The microspheres were evaluated for characteristics such as practical percentage yield, particle size, percentage incorporation efficiency, swellability, zeta potential, in vitro mucoadhesion, thermal analysis, X-ray diffraction study, and in vitro drug diffusion studies. Results: The shape and surface characteristics of the microspheres were determined by scanning electron microscopy, which revealed spherical nature and nearly smooth surface with drug incorporation efficiency in the range of 71.65 ± 1.09% – 91.65 ± 1.13%. In vitro mucoadhesion was observed the range of 79.45 ± 1.69% – 95.48 ± 1.27%. Differential scanning calorimetry and X-ray diffraction results indicated a molecular level dispersion of drug in the microspheres. In vitro drug diffusion was Higuchi matrix controlled and the release mechanism was found to be non-Fickian. Stability studies indicated that there were no significant deviations in the drug content, in vitro mucoadhesion and in vitro drug diffusion characteristics. Conclusion: The investigation revealed promising potential of GG microspheres for delivering ALM intranasally for the

  18. Gastroretentive Ranitidine Hydrochloride Tablets with Combined Floating and Bioadhesive Properties: Factorial Design Analysis, In Vitro Evaluation and In Vivo Abdominal X-Ray Imaging.

    PubMed

    Abduljabbar, Hana N; Badr-Eldin, Shaimaa M; Aldawsari, Hibah M

    2015-01-01

    Ranitidine HCl is an H2-antagonist that suffers from low oral bioavailability of 50%. The site-specific absorption from the upper part of the small intestine and the colonic metabolism of the drug could partially contribute to its reduced bioavailability. To surmount these drawbacks, this work aimed at the formulation of Ranitidine HCl gastroretentive floating-biaodhesive tablets. A 3(2) factorial design was applied to assess the effects of matrix former (HPMC K100M): drug ratio, and the release retardant (Carbopol 971) amount on the characteristics of the tablets prepared using direct compression technique. The prepared tablets were thoroughly evaluated for physical properties, floating, swelling, bioadhesive and in vitro release behaviors. Statistical analysis of the results revealed significant effects for both formulation variables on the swelling index, maximum detachment force and cumulative percent drug released after 6 hours. In addition, the matrix- former: drug ratio showed a statistically significant effect on the floating lag time. Kinetic analysis of the release data indicated Higuchi diffusion kinetics and anomalous transport mechanism for all formulations. Scanning electron micrographs of the selected tablet formulation; F8, revealed intact surface without any perforations or channels in the dry state, while polymer expansion (relaxation) with some perforated areas were observed on the surface of the tablets after 12 hours dissolution in 0.1 N HCl. Furthermore, in vivo abdominal x-ray imaging showed good floating behavior of the selected formulation; F8, for up to 6 hours with appropriate bioadhesive property. In conclusion, the selected ranitidine HCl floating-bioadhesive tablets could be regarded as a promising gastroretentive drug delivery system that could deliver the drug at a controlled rate. PMID:26051347

  19. A novel homocystine-agarose adsorbent for separation and preconcentration of nickel in table salt and baking soda using factorial design optimization of the experimental conditions.

    PubMed

    Hashemi, Payman; Rahmani, Zohreh

    2006-02-28

    Homocystine was for the first time, chemically linked to a highly cross-linked agarose support (Novarose) to be employed as a chelating adsorbent for preconcentration and AAS determination of nickel in table salt and baking soda. Nickel is quantitatively adsorbed on a small column packed with 0.25ml of the adsorbent, in a pH range of 5.5-6.5 and simply eluted with 5ml of a 1moll(-1) hydrochloric acid solution. A factorial design was used for optimization of the effects of five different variables on the recovery of nickel. The results indicated that the factors of flow rate and column length, and the interactions between pH and sample volume are significant. In the optimized conditions, the column could tolerate salt concentrations up to 0.5moll(-1) and sample volumes beyond 500ml. Matrix ions of Mg(2+) and Ca(2+), with a concentration of 200mgl(-1), and potentially interfering ions of Cd(2+), Cu(2+), Zn(2+) and Mn(2+), with a concentration of 10mgl(-1), did not have significant effect on the analyte's signal. Preconcentration factors up to 100 and a detection limit of 0.49mugl(-1), corresponding to an enrichment volume of 500ml, were obtained for the determination of the analyte by flame AAS. Application of the method to the determination of natural and spiked nickel in table salt and baking soda solutions resulted in quantitative recoveries. Direct ETAAS determination of nickel in the same samples was not possible because of a high background observed. PMID:18970514

  20. Evaluation of two evidence-based knowledge transfer interventions for physicians. A cluster randomized controlled factorial design trial: the CardioDAS Study.

    PubMed

    Amsallem, Emmanuel; Kasparian, Christelle; Cucherat, Michel; Chabaud, Sylvie; Haugh, Margaret; Boissel, Jean-Pierre; Nony, Patrice

    2007-12-01

    To investigate the potential benefits of two modes of evidence-based knowledge transfer ('active' and 'passive' modes) in terms of improvement of intention of prescription, knowledge, and real prescription in practice, we performed an open randomized controlled trial (CardioDAS) using a factorial design (two tested interventions: 'active' and 'passive' knowledge transfer) and a hierarchical structure (cluster of physicians for each department level). The participants were cardiologists working in French public hospitals. In the 'passive' transfer group, cardiologists received evidence-based knowledge material (available on Internet) every week for a duration of 1 year. In the 'active' transfer group, two knowledge brokers (EA, PN) visited the participating departments (every 2 months for 1 year, 2 h per visit). The primary outcome consisted in the adjusted absolute mean variation of score (difference between post- and pre-study session) of answers to simulated cases assessing the intention to prescribe. Secondary outcomes were the variation of answers to a multiple-choice questionnaire (MCQ) assessing knowledge and of the conformity of real prescriptions to evidence-based reference assessing the behavioral change. Twenty-two French units (departments) of cardiology were randomized (72 participating cardiologists). In the 'active' transfer group, the primary outcome was more improved than that in the control (P = 0.031 at the department level, absolute mean improvement of 5 points/100). The change in knowledge transfer (MCQ) was also significant (P = 0.039 at the department level, absolute mean improvement of 6 points/100). However, no benefit was shown in terms of prescription conformity to evidence. For the 'passive' mode of knowledge transfer and for the three outcomes considered, no improvement was identified. CardioDAS findings confirm that 'active' knowledge transfer has some impact on participants' intent to prescribe and knowledge, but no effect on

  1. Conceptuation, formulation and evaluation of sustained release floating tablets of captopril compression coated with gastric dispersible hydrochlorothiazide using 2(3) factorial design.

    PubMed

    Sirisha, Pathuri Lakshmi; Babu, Govada Kishore; Babu, Puttagunta Srinivasa

    2014-04-01

    Ambulatory blood pressure monitoring is regarded as the gold standard for hypertensive therapy in non-dipping hypertension patients. A novel compression coated formulation of captopril and hydrochlorothiazide (HCTZ) was developed in order to improve the efficacy of antihypertensive therapy considering the half-life of both drugs. The synergistic action using combination therapy can be effectively achieved by sustained release captopril (t1/2= 2.5 h) and fast releasing HCTZ (average t1/2= 9.5 h). The sustained release floating tablets of captopril were prepared by using 2(3) factorial design by employing three polymers i.e., ethyl cellulose (EC), carbopol and xanthan gum at two levels. The formulations (CF1-CF8) were optimized using analysis of variance for two response variables, buoyancy and T50%. Among the three polymers employed, the coefficients and P values for the response variable buoyancy and T50% using EC were found to be 3.824, 0.028 and 0.0196, 0.046 respectively. From the coefficients and P values for the two response variables, formulation CF2 was optimized, which contains EC polymer alone at a high level. The CF2 formulation was further compression coated with optimized gastric dispersible HCTZ layer (HF9). The compression coated tablet was further evaluated using drug release kinetics. The Q value of HCTZ layer is achieved within 20 min following first order release whereas the Q value of captopril was obtained at 6.5 h following Higuchi model, from which it is proved that rapid release HCTZ and slow release of captopril is achieved. The mechanism of drug release was analyzed using Peppas equation, which showed an n >0.90 confirming case II transportation mechanism for drug release. PMID:25006552

  2. Super B Factory at KEK

    SciTech Connect

    Cheon, Byung Gu

    2008-11-23

    A Super--KEKB factory, an asymmetric--energy e{sup +}e{sup -} lepton collider at KEK in Japan, has been proposed with the design peak luminosity of 8x10{sup 35} cm{sup -2} s{sup -1}, which is about 50 times higher than that of the current operation of the KEKB collider. The physics goal of this project is mainly to measure extremely rare heavy flavor weak decays and CP violation phenomena, which are very sensitive on physics beyond the Standard Model. Hot physics topics and the status of experimental design are briefly described.

  3. Super B Factory at KEK

    NASA Astrophysics Data System (ADS)

    Cheon, ByungGu

    2008-11-01

    A Super—KEKB factory, an asymmetric—energy e+e- lepton collider at KEK in Japan, has been proposed with the design peak luminosity of 8×1035 cm-2 s-1, which is about 50 times higher than that of the current operation of the KEKB collider. The physics goal of this project is mainly to measure extremely rare heavy flavor weak decays and CP violation phenomena, which are very sensitive on physics beyond the Standard Model. Hot physics topics and the status of experimental design are briefly described.

  4. HiPER Tritium factory elements

    NASA Astrophysics Data System (ADS)

    Guillaume, Didier

    2011-06-01

    HiPER will include a Tritium target factory. This presentation is an overview. We start from process ideas to go to first sketch passing through safety principles. We will follow the Tritium management process. We need first a gas factory producing the right gas mixture from hydrogen, Deuterium and Tritium storage. Then we could pass through the target factory. It is based on our LMJ single shot experiment and some new development like the injector. Then comes pellet burst and vapour recovery. The Tritium factory has to include the waste recovery, recycling process with gas purification before storage. At least, a nuclear plant is not a classical building. Tritium is also very special... All the design ideas have to be adapted. Many facilities are necessary, some with redundancy. We all have to well known these constraints. Tritium budget will be a major contributor for a material point of view as for a financial one.

  5. Hollow fiber-based liquid phase microextraction with factorial design optimization and gas chromatography-tandem mass spectrometry for determination of cannabinoids in human hair.

    PubMed

    Emídio, Elissandro Soares; de Menezes Prata, Vanessa; de Santana, Fernando José Malagueño; Dórea, Haroldo Silveira

    2010-08-15

    A new method, based on hollow fiber liquid-phase microextraction (HF-LPME) and gas chromatography-tandem mass spectrometry (GC-MSMS), was developed for determination of Delta(9)-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) in samples of human hair. Since hair is a solid matrix, the samples were subjected to alkaline digestion using NaOH. The aqueous solutions obtained were extracted using a 6cm polypropylene fiber (600microm i.d., 200microm wall thickness, 0.2microm pore size) for each extraction. A 2(5-1) fractional factorial design for screening, and a central composite design for optimization of significant variables, was applied during development of the extraction method. The variables evaluated were the type of extraction solvent, pH, stirring speed, extraction time, and acceptor phase volume. The optimized conditions for the proposed extraction procedure were 10mg of hair sample; 20microL of butyl acetate; aqueous (pH 14) donor phase containing 6.8% NaCl; 600rpm stirring speed; 20min extraction time. A linear response was obtained in the ranges 1-500pgmg(-1) (CBD and CBN) and 20-500pgmg(-1) (THC), with regression coefficients >0.99. Precision, determined as the relative standard deviation, was 3.3-8.9% (intra-day) and 4.4-13.7% (inter-day). Absolute recoveries varied in the ranges 4.4-4.8% (CBD), 7.6-8.9% (THC) and 7.7-8.2% (CBN). Limits of detection (LOD, S/N=3) and quantification (LOQ, S/N=10) were 0.5-15pgmg(-1) and 1-20pgmg(-1), respectively. The method was successfully used to determine CBD, THC and CBN in hair samples from patients in a drug dependency rehabilitation center. Concentrations varied in the ranges 1-18pgmg(-1) (CBD), 20-232pgmg(-1) (THC) and 9-107pgmg(-1) (CBN), confirming the suitability of the method for monitoring studies. PMID:20655815

  6. Perspective view of threestory reinforced concrete factory. The factory is ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective view of three-story reinforced concrete factory. The factory is painted pink with factory windows infilling the structural frame exposed on the exterior facade. On the east facade of the three-story factory is a two-story, seven bay addition that is painted the same tone as the larger factory. The last two bays of the two-story addition are newer. A brick base surrounds both the factory and the addition and runs the entire length of the building on Clay Ave. and Morrow St. (Duplicate Color view of HAER MI-334-1) - Ivan Doverspike Company, 1925 Clay Avenue, Detroit, MI

  7. Perspective view of threestory reinforced concrete factory. The factory is ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective view of three-story reinforced concrete factory. The factory is painted pink with factory windows infilling the structural frame exposed on the exterior facade. On the east facade of the three-story factory is a two-story, seven bay addition that is painted the same tone as the larger factory. The last two bays of the two-story addition are newer. A brick base surrounds both the factory and the addition and runs the entire length of the building on Clay Ave. and Morrow St - Ivan Doverspike Company, 1925 Clay Avenue, Detroit, MI

  8. Improved optimization of polycyclic aromatic hydrocarbons (PAHs) mixtures resolution in reversed-phase high-performance liquid chromatography by using factorial design and response surface methodology.

    PubMed

    Andrade-Eiroa, Auréa; Diévart, Pascal; Dagaut, Philippe

    2010-04-15

    A new procedure for optimizing PAHs separation in very complex mixtures by reverse phase high performance (RPLC) is proposed. It is based on changing gradually the experimental conditions all along the chromatographic procedure as a function of the physical properties of the compounds eluted. The temperature and speed flow gradients allowed obtaining the optimum resolution in large chromatographic determinations where PAHs with very different medium polarizability have to be separated. Whereas optimization procedures of RPLC methodologies had always been accomplished regardless of the physico-chemical properties of the target analytes, we found that resolution is highly dependent on the physico-chemical properties of the target analytes. Based on resolution criterion, optimization process for a 16 EPA PAHs mixture was performed on three sets of difficult-to-separate PAHs pairs: acenaphthene-fluorene (for the optimization procedure in the first part of the chromatogram where light PAHs elute), benzo[g,h,i]perylene-dibenzo[a,h]anthracene and benzo[g,h,i]perylene-indeno[1,2,3-cd]pyrene (for the optimization procedure of the second part of the chromatogram where the heavier PAHs elute). Two-level full factorial designs were applied to detect interactions among variables to be optimized: speed flow, temperature of column oven and mobile-phase gradient in the two parts of the studied chromatogram. Experimental data were fitted by multivariate nonlinear regression models and optimum values of speed flow and temperature were obtained through mathematical analysis of the constructed models. An HPLC system equipped with a reversed phase 5 microm C18, 250 mm x 4.6mm column (with acetonitrile/water mobile phase), a column oven, a binary pump, a photodiode array detector (PDA), and a fluorimetric detector were used in this work. Optimum resolution was achieved operating at 1.0 mL/min in the first part of the chromatogram (until 45 min) and 0.5 mL/min in the second one (from 45

  9. Kinetics of improved 1,4-alpha-D-glucan glucohydrolase biosynthesis from a newly isolated Aspergillus oryzae IIB-6 and parameter significance analysis by 2-factorial design.

    PubMed

    Fatima, Bilqees; Ali, Sikander

    2012-01-01

    Sixteen different mould cultures viz. Aspergillus, Alternaria, Arthroderma, Trichoderma, Fusarium, Penicillium, Rhizopus and Chochliobolus were isolated from the soil samples of Qatar by serial dilution method. The preliminary screening of isolates was done by selecting initial colonies showing relatively bigger zones of starch hydrolysis on nutrient agar plates. The isolates were then subjected to secondary screening by submerged fermentation (SmF). The 1,4-α-D-glucan glucohydrolase (GGH) activity ranged from 1.906-12.675 U/ml/min. The product yield was analysed in dependence of mycelial morphology, biomass level and protein content. The isolate Aspergillus oryzae llB-6 which gave maximum enzyme production was incubated in M3 medium containing 20 g/l starch, 10 g/l lactose, 8.5 g/l yeast extract, 6 g/l corn steep liquor (CSL), 1.2 g/l MgSO4.7H2O, 1.3 g/l NH4Cl, 0.6 g/l CaCl2.2H2O, pH 5 at 30±2°C and 200 rpm. On the basis of kinetic variables, notably Qp (0.058±0.01(a) U/g/h), Yp/s (0.308±0.03(ab) U/g) and qp (0.210±0.032(abc) U/g fungal biomass/h), A. oryzae IIB-6 was found to be a hyper producer of GGH (LSD 0.0345) compared to A. kawachii IIB-2. A noticeable enhancement in enzyme activity of over 30% was observed (13.917±1.01 U/ml/min) when the process parameters viz. cultural conditions (pH 5, incubation period 72 h) and nutritional requirements (6 g/l CSL, 9.5 g/l yeast extract, 10 g/l starch, 20 g/l lactose) were further optimized using a 2-factorial Plackett-Burman design. The model terms were found to be highly significant (HS, p≤0.05), indicating the potential utility of the culture (dof~3). PMID:23961361

  10. Near Detectors for a Neutrino Factory

    SciTech Connect

    Morfin, Jorge G.

    2011-11-23

    The baseline design for a Neutrino Factory includes the need for one or more near detectors.The near detectors must be designed to carry out measurements essential to the sensitivity of the oscillation-physics program. In addition, the intense neutrino beam delivered by the Neutrino Factory makes it possible to carry out a unique neutrino-physics program at the near detectors. This program includes fundamental electroweak and QCD physics. The near detector must also be capable of searching for new physics, for example by detecting tau-leptons which are particularly sensitive probes of non-standard interactions at source and at detection. This paper is extracted from the Near Detector chapter of the Neutrino Factory Interim Design Report.

  11. NUCLEAR ENERGY RESEARCH INITIATIVE (NERI) PROGRAM GRANT NUMBER DE-FG03-00SF22168 TECHNICAL PROGRESS REPORT (Aug 15, 2002 to Nov. 15, 2002) - DESIGN AND LAYOUT CONCEPTS FOR COMPACT, FACTORY-PRODUCED, TRANSPORTABLE GENERATION IV REACTOR SYSTEMS

    SciTech Connect

    Fred R. Mynatt; Andy Kadak; Marc Berte; Larry Miller; Lawrence Townsend; Martin Williamson; Rupy Sawhney; Jacob Fife

    2002-12-15

    The objectives of this project are to develop and evaluate nuclear power plant designs and layout concepts to maximize the benefits of compact modular Generation IV reactor concepts including factory fabrication and packaging for optimal transportation and siting. This report covers the ninth quarter of the project. The three reactor concept teams have completed initial plant concept development, evaluation and layout. A significant design effort has proceeded with substantial change and evolution from original ideas. The concepts have been reviewed by the industry participants and improvements have been implemented. The third phase, industrial engineering simulation of reactor fabrication has begun.

  12. Neutrino Factories and Beta Beams

    SciTech Connect

    Zisman, Michael S.

    2006-06-21

    In this paper we briefly review the concepts of Neutrino Factories and Beta Beam facilities, and indicate the main challenges in terms of beam performance and technological developments. We also describe the worldwide organizations that have embarked on defining and carrying out the necessary R&D on component design, beam simulations of facility performance, and benchmarking of key subsystems via actual beam tests. Currently approved subsystem tests include the Muon Ionization Cooling Experiment (MICE), under construction at Rutherford Appleton Laboratory, and the Mercury Intense Target (MERIT) experiment, to be carried out at CERN. These experiments are briefly described, and their schedules are indicated.

  13. Integrating PCLIPS into ULowell's Lincoln Logs: Factory of the future

    NASA Technical Reports Server (NTRS)

    Mcgee, Brenda J.; Miller, Mark D.; Krolak, Patrick; Barr, Stanley J.

    1990-01-01

    We are attempting to show how independent but cooperating expert systems, executing within a parallel production system (PCLIPS), can operate and control a completely automated, fault tolerant prototype of a factory of the future (The Lincoln Logs Factory of the Future). The factory consists of a CAD system for designing the Lincoln Log Houses, two workcells, and a materials handling system. A workcell consists of two robots, part feeders, and a frame mounted vision system.

  14. A randomized 3x3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults

    PubMed Central

    2013-01-01

    Background The behavioral outcome of food ingestion is a complex process that involves psychological and biological factors. Avocados are nutrient dense with properties that may favorably impact energy balance. This study sought to evaluate if incorporating approximately one half of a Hass avocado by addition or inclusion into a lunch meal will influence post-ingestive satiety, glucose and insulin response, and subsequent energy intake among overweight adults. Methods This was a randomized 3x3 single-blind crossover design study with 26 healthy overweight adults (mean ±SD age 40.8±11.0 years and BMI 28.1±2.4 kg/m2). Participants consumed a standardized breakfast followed by 1 of 3 lunch test meals [Control (C), avocado-free; Avocado Inclusive (AI); and, Avocado Added (AA)]. Participants rated five appetite sensations using a visual analog scale (VAS) before lunch and at specific intervals over 5 hours following the start of the test meal. Blood glucose and insulin were measured before lunch and at specific intervals over 3 hours following the start of the test meal. Mixed models were used to compare differences among the 3 test meals, and the area under the curve (AUC0-xh) was computed for the VAS and biological measures. Results There were significant differences in the AUC(0-5h) for the self-reported feelings of satisfaction (P=0.04) and desire to eat (P=0.05) in the mixed model analysis. Compared to the C test meal, the AA test meal increased satisfaction by 23% (P=0.05) and decreased the desire to eat by 28% (P=0.04) for the AUC(0-5h). For the AUC(0-3h), the AA test meal increased satisfaction by 26% (P=0.02) and decreased the desire to eat by 40% (P=0.01) as compared to the C test meal. Compared to the AI meal, the AUC(0-3h) for blood insulin was higher in the C and AA meals (P=0.04 and P=0.05, respectively). Conclusions The addition of approximately one half of a Hass avocado at a lunch meal can influence post-ingestive satiety over a subsequent 3 and 5

  15. The Invention Factory

    ERIC Educational Resources Information Center

    Speitel, Thomas W.; Scott, Neil G.; Gabrielli, Sandy D.

    2007-01-01

    The Invention Factory is a nontraditional youth-based, after-school program in Honolulu that teaches information technology and mechanics to teenagers through interactive, hands-on projects that improve human computer interaction for individuals with disabilities. One objective of the program is to stimulate interest in science and engineering…

  16. Neutrino Factory Downstream Systems

    SciTech Connect

    Zisman, Michael S.

    2009-12-23

    We describe the Neutrino Factory accelerator systems downstream from the target and capture area. These include the bunching and phase rotation, cooling, acceleration, and decay ring systems. We also briefly discuss the R&D program under way to develop these systems, and indicate areas where help from CERN would be invaluable.

  17. The Clone Factory

    ERIC Educational Resources Information Center

    Stoddard, Beryl

    2005-01-01

    Have humans been cloned? Is it possible? Immediate interest is sparked when students are asked these questions. In response to their curiosity, the clone factory activity was developed to help them understand the process of cloning. In this activity, students reenact the cloning process, in a very simplified simulation. After completing the…

  18. Identification of Analytical Factors Affecting Complex Proteomics Profiles Acquired in a Factorial Design Study with Analysis of Variance: Simultaneous Component Analysis.

    PubMed

    Mitra, Vikram; Govorukhina, Natalia; Zwanenburg, Gooitzen; Hoefsloot, Huub; Westra, Inge; Smilde, Age; Reijmers, Theo; van der Zee, Ate G J; Suits, Frank; Bischoff, Rainer; Horvatovich, Péter

    2016-04-19

    Complex shotgun proteomics peptide profiles obtained in quantitative differential protein expression studies, such as in biomarker discovery, may be affected by multiple experimental factors. These preanalytical factors may affect the measured protein abundances which in turn influence the outcome of the associated statistical analysis and validation. It is therefore important to determine which factors influence the abundance of peptides in a complex proteomics experiment and to identify those peptides that are most influenced by these factors. In the current study we analyzed depleted human serum samples to evaluate experimental factors that may influence the resulting peptide profile such as the residence time in the autosampler at 4 °C, stopping or not stopping the trypsin digestion with acid, the type of blood collection tube, different hemolysis levels, differences in clotting times, the number of freeze-thaw cycles, and different trypsin/protein ratios. To this end we used a two-level fractional factorial design of resolution IV (2(IV)(7-3)). The design required analysis of 16 samples in which the main effects were not confounded by two-factor interactions. Data preprocessing using the Threshold Avoiding Proteomics Pipeline (Suits, F.; Hoekman, B.; Rosenling, T.; Bischoff, R.; Horvatovich, P. Anal. Chem. 2011, 83, 7786-7794, ref 1) produced a data-matrix containing quantitative information on 2,559 peaks. The intensity of the peaks was log-transformed, and peaks having intensities of a low t-test significance (p-value > 0.05) and a low absolute fold ratio (<2) between the two levels of each factor were removed. The remaining peaks were subjected to analysis of variance (ANOVA)-simultaneous component analysis (ASCA). Permutation tests were used to identify which of the preanalytical factors influenced the abundance of the measured peptides most significantly. The most important preanalytical factors affecting peptide intensity were (1) the hemolysis level

  19. Sequence Factorial and Its Applications

    ERIC Educational Resources Information Center

    Asiru, Muniru A.

    2012-01-01

    In this note, we introduce sequence factorial and use this to study generalized M-bonomial coefficients. For the sequence of natural numbers, the twin concepts of sequence factorial and generalized M-bonomial coefficients, respectively, extend the corresponding concepts of factorial of an integer and binomial coefficients. Some latent properties…

  20. Review of U.S. Neutrino Factory Studies

    SciTech Connect

    Zisman, Michael S.

    2005-08-23

    We summarize the status of the two U.S. feasibility studies carried out by the Neutrino Factory and Muon Collider Collaboration (NFMCC) along with recent improvements to Neutrino Factory design developed during the American Physical Society (APS) Neutrino Physics Study. Suggested accelerator topics for the International Scoping Study (ISS) are also indicated.

  1. Muon Front-End for the Neutrino Factory

    NASA Astrophysics Data System (ADS)

    Fernow, R. C.

    2006-05-01

    The front end at a neutrino factory includes all the systems necessary for capturing the pion beam produced at the target and for preparing the transverse and longitudinal phase space of the resulting muon beam for subsequent acceleration to high energies. We compare front end configurations for a number of neutrino factory designs.

  2. Multivariate optimization of process parameters in the synthesis of calcined Ca‒Al (NO3) LDH for defluoridation using 3(3) factorial, central composite and Box-Behnken design.

    PubMed

    Ghosal, Partha S; Gupta, Ashok K; Sulaiman, Ayoob

    2016-01-01

    Response surface methodology was applied for the first time in the optimization of the preparation of layered double hydroxide (LDH) for defluoridation. The influence of three vital process parameters (viz. pH, molar ratio and calcination temperature) in the synthesis of the adsorbent 'Calcined Ca‒Al (NO3) LDH' was thoroughly examined to maximize its fluoride scavenging potential. The process parameters were optimized using the 3(3) factorial, face centered central composite and Box-Behnken designs and a comparative assessment of the methods was conducted. The maximum fluoride removal efficiency was achieved at a calcination temperature of approximately 500ºC; however, the efficiency decreased with increasing pH and molar ratio. The outcome of the comparative assessment clearly delineates the case specific nature of the models. A better predictability over the entire experimental domain was obtained with the 3(3) factorial method, whereas the Box-Behnken design was found to be the most efficient model with lesser number of experimental runs. The desirability function technique was performed for optimizing the response, wherein face centered central composite design exhibited a maximum desirability. The calcined Ca‒Al (NO3) LDH, synthesized under the optimum conditions, demonstrated the removal efficiencies of 95% and 99% for the doses of 3 g L(-1) and 5 g L(-1), respectively. PMID:26549036

  3. B-factories

    SciTech Connect

    Bloom, E.D.

    1988-04-01

    We briefly review the physics of CP violation and the interest of studying this phenomenon in the B-meson system. The need for very large numbers of B-decays is shown, and a number of approaches for B-factories are compared. In particular, e/sup +/e/sup /minus// linear and circular colliders are discussed in some detail, with specific examples presented. 31 refs., 22 figs., 5 tabs.

  4. SLAC B Factory computing

    SciTech Connect

    Kunz, P.F.

    1992-02-01

    As part of the research and development program in preparation for a possible B Factory at SLAC, a group has been studying various aspects of HEP computing. In particular, the group is investigating the use of UNIX for all computing, from data acquisition, through analysis, and word processing. A summary of some of the results of this study will be given, along with some personal opinions on these topics.

  5. The Idea Factory: An Interactive Intergroup Exercise

    ERIC Educational Resources Information Center

    Rosh, Lisa; Leach, Evan

    2011-01-01

    This article outlines the Idea Factory exercise, an interactive exercise designed to help participants examine group, individual, and organizational factors that affect intergroup conflict. Specific emphasis is placed on exploring the relationship between intra- and intergroup dynamics and identifying managerial practices that foster effective…

  6. Exploring design features for enhancing players' challenge in strategy games.

    PubMed

    Hsu, Shang Hwa; Wen, Ming-Hui; Wu, Muh-Cherng

    2007-06-01

    This paper examines how to make a player feel more challenged in a strategic computer game. It is hypothesized that information availability and resource advantage affect play difficulty, which in turn affects the challenge experienced. The difficulty of play can be defined in terms of the mental workload that players experience and the physical effort that players exert. Forty-five male college and graduate students participated in a 3 x 3 (information availability x resource advantage) between-subjects factorial design experiment. This experiment measured player mental workload, physical effort, and challenge. The results indicate that information availability affects player mental workload, and resource advantage affects levels of player physical effort, respectively. Moreover, the relationship between mental workload and challenge was found to be an inverted U-shaped curve; in other words, too much or too little mental workload may decrease player challenge. The relationship between physical effort and challenge exhibited similar characteristics. PMID:17594263

  7. Sequence factorial and its applications

    NASA Astrophysics Data System (ADS)

    Asiru, Muniru A.

    2012-06-01

    In this note, we introduce sequence factorial and use this to study generalized M-bonomial coefficients. For the sequence of natural numbers, the twin concepts of sequence factorial and generalized M-bonomial coefficients, respectively, extend the corresponding concepts of factorial of an integer and binomial coefficients. Some latent properties of generalized M-bonomial coefficients by which a vast majority of practical problems involving generalized M-bonomial coefficients can be solved are derived.

  8. CHOICE OF PROTON DRIVER PARAMETERS FOR A NEUTRINO FACTORY.

    SciTech Connect

    KIRK, H.G.; BERG, J.S.; FERNOW, R.C.; GALLARDO, J.C.; SIMOS, N.; WENG, W.

    2006-06-23

    We discuss criteria for designing an optimal ''green field'' proton driver for a neutrino factory. The driver parameters are determined by considerations of space charge, power capabilities of the target, beam loading and available RF peak power.

  9. Perspectives on Higher Luminosity B-Factories

    SciTech Connect

    Seeman, J

    2004-04-22

    The present B-factories PEP-II and KEKB have reached luminosities of 4-6 x 10{sup 33}/cm{sup 2}/s and delivered integrated luminosity at rates in excess of 6 fb{sup -1} per month [1,2]. The recent turn on of these two B-Factories has shown that modern accelerator physics, design, and engineering can produce colliders that rapidly reach their design luminosities and deliver integrated luminosities capable of frontier particle physics discoveries. PEP-II and KEK-B with ongoing upgrade programs should reach luminosities of over 10{sup 34}/cm{sup 2}/s in a few years and with more aggressive improvements may reach luminosities of order 4 x 10{sup 34}/cm{sup 2}/s by the end of the decade. However, due to particle physics requirements, the next generation B-Factory may require significantly more luminosity. Initial parameters of a very high luminosity e{sup +}e{sup -} B-Factory or Super B-Factory (SBF) are being developed incorporating several new ideas from the successful operation of the present generation e{sup +}e{sup -} accelerators [3,4]. A luminosity approaching 10{sup 36} cm{sup -2}s{sup -1} may be possible. Furthermore, the ratio of average to peak luminosity may be increased by 30% due to continuous injection. The operation of this new accelerator will be qualitatively different from present e{sup +}e{sup -} colliders due to this continuous injection.

  10. Electropolishing of Re-melted SLM Stainless Steel 316L Parts Using Deep Eutectic Solvents: 3 × 3 Full Factorial Design

    NASA Astrophysics Data System (ADS)

    Alrbaey, K.; Wimpenny, D. I.; Al-Barzinjy, A. A.; Moroz, A.

    2016-07-01

    This three-level three-factor full factorial study describes the effects of electropolishing using deep eutectic solvents on the surface roughness of re-melted 316L stainless steel samples produced by the selective laser melting (SLM) powder bed fusion additive manufacturing method. An improvement in the surface finish of re-melted stainless steel 316L parts was achieved by optimizing the processing parameters for a relatively environmentally friendly (`green') electropolishing process using a Choline Chloride ionic electrolyte. The results show that further improvement of the response value-average surface roughness ( Ra) can be obtained by electropolishing after re-melting to yield a 75% improvement compared to the as-built Ra. The best Ra value was less than 0.5 μm, obtained with a potential of 4 V, maintained for 30 min at 40 °C. Electropolishing has been shown to be effective at removing the residual oxide film formed during the re-melting process. The material dissolution during the process is not homogenous and is directed preferentially toward the iron and nickel, leaving the surface rich in chromium with potentially enhanced properties. The re-melted and polished surface of the samples gave an approximately 20% improvement in fatigue life at low stresses (approximately 570 MPa). The results of the study demonstrate that a combination of re-melting and electropolishing provides a flexible method for surface texture improvement which is capable of delivering a significant improvement in surface finish while holding the dimensional accuracy of parts within an acceptable range.

  11. Electropolishing of Re-melted SLM Stainless Steel 316L Parts Using Deep Eutectic Solvents: 3 × 3 Full Factorial Design

    NASA Astrophysics Data System (ADS)

    Alrbaey, K.; Wimpenny, D. I.; Al-Barzinjy, A. A.; Moroz, A.

    2016-05-01

    This three-level three-factor full factorial study describes the effects of electropolishing using deep eutectic solvents on the surface roughness of re-melted 316L stainless steel samples produced by the selective laser melting (SLM) powder bed fusion additive manufacturing method. An improvement in the surface finish of re-melted stainless steel 316L parts was achieved by optimizing the processing parameters for a relatively environmentally friendly (`green') electropolishing process using a Choline Chloride ionic electrolyte. The results show that further improvement of the response value-average surface roughness (Ra) can be obtained by electropolishing after re-melting to yield a 75% improvement compared to the as-built Ra. The best Ra value was less than 0.5 μm, obtained with a potential of 4 V, maintained for 30 min at 40 °C. Electropolishing has been shown to be effective at removing the residual oxide film formed during the re-melting process. The material dissolution during the process is not homogenous and is directed preferentially toward the iron and nickel, leaving the surface rich in chromium with potentially enhanced properties. The re-melted and polished surface of the samples gave an approximately 20% improvement in fatigue life at low stresses (approximately 570 MPa). The results of the study demonstrate that a combination of re-melting and electropolishing provides a flexible method for surface texture improvement which is capable of delivering a significant improvement in surface finish while holding the dimensional accuracy of parts within an acceptable range.

  12. IDR Neutrino Factory Front End and Variations

    SciTech Connect

    Neuffer, D.; Alekou, A.; Rogers, C.; Snopok, P.; Yoshikawa, C.; /MUONS Inc., Batavia

    2012-05-01

    The International Design Report (IDR) neutrino factory scenario for capture, bunching, phase-energy rotation and initial cooling of {mu}'s produced from a proton source target is explored. It requires a drift section from the target, a bunching section and a {phi}-{delta}E rotation section leading into the cooling channel. Optimization and variations are discussed. Important concerns are rf limitations within the focusing magnetic fields and large losses in the transport.

  13. Status of the Super B Factory Projects

    SciTech Connect

    Sangro, Riccardo de

    2010-08-05

    Two proposals have been presented for the construction of super high luminosity B factories, the SuperB in Italy and SuperKEKB in Japan. We review the physics case for the construction of such facilities in the LHC era and highlight several topics of hadronic physics that can benefit from the high luminosity they will integrate. The present status of the accelerator and detector work toward the Technical Design Reports is also presented.

  14. Muon front end for the neutrino factory

    NASA Astrophysics Data System (ADS)

    Rogers, C. T.; Stratakis, D.; Prior, G.; Gilardoni, S.; Neuffer, D.; Snopok, P.; Alekou, A.; Pasternak, J.

    2013-04-01

    In the neutrino factory, muons are produced by firing high-energy protons onto a target to produce pions. The pions decay to muons and pass through a capture channel known as the muon front end, before acceleration to 12.6 GeV. The muon front end comprises a variable frequency rf system for longitudinal capture and an ionization cooling channel. In this paper we detail recent improvements in the design of the muon front end.

  15. An asymmetric B factory based on PEP

    SciTech Connect

    Not Available

    1991-02-01

    In this report we describe a design for a high-luminosity Asymmetric B Factory to be built in the PEP tunnel on the SLAC site. This proposal, a collaborative effort SLAC, LBL, and LLNL, is the culmination of more than two years of effort aimed at the design and construction of an asymmetric e{sup +}e{sup {minus}} collider capable of achieving a luminosity of L = 3 {times} 10{sup 33} cm{sup {minus}2} s{sup {minus}1}. The configuration adopted utilizes two storage rings, and electron ring operating at 9 GeV and a positron ring at 3.1 GeV, each with a circumference of 2200 m. The high-energy ring is an upgrade of the PEP storage ring at SLAC; all PEP magnets and most power supplies will be reused. The upgrade consists primarily of replacing the PEP vacuum chamber and RF system with newly designed versions optimized for the high-current environment of the B Factory. The low-energy ring will be newly constructed and will be situated atop the high-energy ring in the PEP tunnel. Utilities already installed in the PEP tunnel are largely sufficient to operate the two B Factory storage rings.

  16. Laser-cooled radioactive francium factory at CYRIC

    NASA Astrophysics Data System (ADS)

    Kawamura, Hirokazu; Arikawa, H.; Ezure, S.; Harada, K.; Hayamizu, T.; Inoue, T.; Ishikawa, T.; Itoh, M.; Kato, T.; Sato, T.; Aoki, T.; Furukawa, T.; Hatakeyama, A.; Hatanaka, K.; Imai, K.; Murakami, T.; Nataraj, H. S.; Shimizu, Y.; Wakasa, T.; Yoshida, H. P.; Sakemi, Y.

    2013-12-01

    A factory of laser-cooled francium (Fr) atoms is being developed to search for the electric dipole moment (EDM) of the electron. The factory has achieved the production of Fr ions of 9 × 105 particles/s and transport with a transmission efficiency of 2%. In pilot experiments, the magneto-optical trapping of rubidium (Rb) has been performed using a new ion-to-atom converter. To achieve the Fr trap, the development and design of each of the factory's components are in progress.

  17. The eldercare factory.

    PubMed

    Sharkey, Noel; Sharkey, Amanda

    2012-01-01

    Rapid advances in service robotics together with dramatic shifts in population demographics have led to the notion that technology may be the answer to our eldercare problems. Robots are being developed for feeding, washing, lifting, carrying and mobilising the elderly as well as monitoring their health. They are also being proposed as a substitute for companionship. While these technologies could accrue major benefits for society and empower the elderly, we must balance their use with the ethical costs. These include a potential reduction in human contact, increased feeling of objectification and loss of control, loss of privacy and personal freedom as well as deception and infantilisation. With appropriate guidelines in place before the introduction of robots en masse into the care system, robots could improve the lives of the elderly, reducing their dependence and creating more opportunities for social interaction. Without forethought, the elderly may find themselves in a barren world of machines, a world of automated care: a factory for the elderly. PMID:21952502

  18. DKIST enclosure fabrication factory assembly and testing

    NASA Astrophysics Data System (ADS)

    Murga, Gaizka; Marshall, Heather K.; Lorentz, Thomas E.; Ariño, Javier; Ampuero, Pedro

    2014-07-01

    After successfully finishing the design of the Advanced Technology Solar Telescope (ATST) Enclosure early in 2012, AEC IDOM, in close collaboration with the ATST Project Office, has successfully fabricated the enclosure's main components (structure, mechanisms, controls, and cladding), assembled them in the factory, and performed the factory acceptance tests. The factory assembly and testing of the enclosure has allowed the team to verify the correct integration and performance of structures, mechanisms, and controls. Furthermore, the assembly and verification procedures to be used for the enclosure re-assembly at the Haleakala High Altitude Observatory Site have been tested and refined in order to reduce risk during the enclosure site construction, an overall project critical path activity. The Advanced Technology Solar Telescope (ATST), recently renamed as the Daniel K. Inouye Solar Telescope (DKIST) will be the largest solar telescope in the world, with unprecedented abilities to view details of the sun. Using adaptive optics technology, DKIST will be able to provide the sharpest views ever taken of the solar surface, which will allow scientists to learn even more about the Sun and solar-terrestrial interactions. The DKIST Enclosure is unique in that it positions the optical system's first aperture stop and tracks the sun's motion with millimeter-level accuracy, protecting observatory components from excess insolation. Its azimuth and altitude systems are driven by mechanisms especially designed to perform smooth operations at tracking speeds.

  19. Pion Production for Neutrino Factory-challenges

    SciTech Connect

    Breton, Florian; Le Couedic, Clement; Soler, F. J. P.

    2011-10-06

    One of the key issues in the design of a Neutrino Factory target station is the determination of the optimum kinetic energy of the proton beam due to the large uncertainties in simulations of protons impinging on nuclear targets. In this paper we have developed a procedure to correct GEANT4 simulations for the HARP data, and we have determined the yield of muons expected at the front-end of a Neutrino Factory as a function of target material (Be, C, Al, Ta and Pb) and energy (3-12 GeV).The maximum muon yield is found between 5 and 8 GeV for high Z targets and 3 GeV for low Z targets.

  20. Pion Production for Neutrino Factory-challenges

    NASA Astrophysics Data System (ADS)

    Breton, Florian; Couedic, Clément Le; Soler, F. J. P.

    2011-10-01

    One of the key issues in the design of a Neutrino Factory target station is the determination of the optimum kinetic energy of the proton beam due to the large uncertainties in simulations of protons impinging on nuclear targets. In this paper we have developed a procedure to correct GEANT4 simulations for the HARP data, and we have determined the yield of muons expected at the front-end of a Neutrino Factory as a function of target material (Be, C, Al, Ta and Pb) and energy (3-12 GeV).The maximum muon yield is found between 5 and 8 GeV for high Z targets and 3 GeV for low Z targets.

  1. On the Expectations of Mean Squares Based on Nonindependent Variates in Factorials.

    ERIC Educational Resources Information Center

    Draper, John F.

    A study was made of the problem of representing the expectations of mean squares associated with analysis of variance sources of variation for experimental designs. These designs have a factorial structure over repeated measures or, for some other reason, have variates within a factorial design not all of which are mutually independent. A simple…

  2. Design of a surface-based factory for the production of life support and technology support products. Phase 2: Integrated water system for a space colony

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Phase 2 of a conceptual design of an integrated water treatment system to support a space colony is presented. This includes a breathable air manufacturing system, a means of drilling for underground water, and storage of water for future use. The system is to supply quality water for biological consumption, farming, residential and industrial use and the water source is assumed to be artesian or subsurface and on Mars. Design criteria and major assumptions are itemized. A general block diagram of the expected treatment system is provided. The design capacity of the system is discussed, including a summary of potential users and the level of treatment required; and, finally, various treatment technologies are described.

  3. Factorial Analysis of Generalizability

    ERIC Educational Resources Information Center

    Erlich, Oded; Borich, Gary

    1978-01-01

    An overview of generalizability theory and a FORTRAN computer program for studying the generalizability of scores in a three facet, four factor design are presented. An illustrative example is presented. (Author/JKS)

  4. Process optimization for the preparation of oligomycin-loaded folate-conjugated chitosan nanoparticles as a tumor-targeted drug delivery system using a two-level factorial design method

    PubMed Central

    Zu, Yuangang; Zhao, Qi; Zhao, Xiuhua; Zu, Shuchong; Meng, Li

    2011-01-01

    Oligomycin-A (Oli-A), an anticancer drug, was loaded to the folate (FA)-conjugated chitosan as a tumor-targeted drug delivery system for the purpose of overcoming the nonspecific targeting characteristics and the hydrophobicity of the compound. The two-level factorial design (2-LFD) was applied to modeling the preparation process, which was composed of five independent variables, namely FA-conjugated chitosan (FA-CS) concentration, Oli-A concentration, sodium tripolyphosphate (TPP) concentration, the mass ratio of FA-CS to TPP, and crosslinking time. The mean particle size (MPS) and the drug loading rate (DLR) of the resulting Oli-loaded FA-CS nanoparticles (FA-Oli-CSNPs) were used as response variables. The interactive effects of the five independent variables on the response variables were studied. The characteristics of the nanoparticles, such as amount of FA conjugation, drug entrapment rate (DER), DLR, surface morphology, and release kinetics properties in vitro were investigated. The FA-Oli-CSNPs with MPS of 182.6 nm, DER of 17.3%, DLR of 58.5%, and zeta potential (ZP) of 24.6 mV were obtained under optimum conditions. The amount of FA conjugation was 45.9 mg/g chitosan. The FA-Oli-CSNPs showed sustained-release characteristics for 576 hours in vitro. The results indicated that FA-Oli-CSNPs obtained as a targeted drug delivery system could be effective in the therapy of leukemia in the future. PMID:22267927

  5. W.K.H. Panofsky Prize in Experimental Particle Physics: The design, construction and performance of the B Factory accelerator facilities, PEP-II and KEKB

    NASA Astrophysics Data System (ADS)

    Dorfan, Jonathan

    2016-03-01

    The discovery and elucidation of CP violation in the B-meson system presented daunting challenges for the accelerator and detector facilities. This talk discusses how these challenges were met and overcome in the electron-positron colliding-beam accelerator facilities PEP-II (at SLAC) and KEKB (at KEK). The key challenge was to produce unprecedentedly large numbers of B-mesons in a geometry that provided high-statistics, low-background samples of decays to CP eigenstates. This was realized with asymmetric collisions at the Γ(4S) at peak luminosities in excess of 3 ×1033 /sq. cm/sec. Specialized optics were developed to generate efficient, low background, multi-bunch collisions in an energy-asymmetric collision geometry. Novel technologies for the RF, vacuum and feedback systems permitted the storage of multi-amp, multi-bunch beams of electrons and positrons, thereby generating high peak luminosities. Accelerator uptimes greater than 95 percent, combined with high-intensity injection systems, ensured large integrated luminosity. Both facilities rapidly attained their design specifications and ultimately far exceeded the projected performance expectations for both peak and integrated luminosity.

  6. Design and characterisation of long-R3-insulin-like growth factor-I muteins which show resistance to pepsin digestion.

    PubMed

    Bryant, K J; Read, L C; Forsberg, G; Wallace, J C

    1996-01-01

    Site-directed mutagenesis was used to construct pepsin-resistant, single-point mutations of the N-terminal extended IGF-I analogue, long-R3-IGF-I. In order to identify the most susceptible sites, the kinetics of long-R3-IGF-I digestion by purified porcine pepsin were determined. Pepsin initially cleaved the Leu10-Phe11 bond in the N-terminal extension peptide to generate FVN-R3-IGF-I, followed in rapid succession by cleavage at Gln15-Phe16, Tyr24-Phe25, Leu10-Val11 and Met59-Tyr60 in the IGF-I moiety. Single-point mutations at these sites were designed on the basis of the preferred cleavage bonds for pepsin, as well as amino acid substitutions less likely to disturb protein structure. These included Leu10Val, Phe16Ala, Phe25Leu, Asp53Glu and Met59Gln. All five muteins retained growth-promoting activity equivalent to or higher than that of IGF-I. In terms of pepsin susceptibility, Leu10Val and Asp53Glu were degraded as rapidly as the parent long-R3-IGF-I, Met59Gln and Phe25Leu were partially stabilised, and Phe16Ala showed a marked improvement in stability over a wide range of pepsin:substrate ratios. Accordingly, the Phe16Ala mutein, long-R3A16-IGF-I, has potential for oral applications to enhance gastric growth and repair. PMID:8919033

  7. An Asymmetric B Factory based on PEP

    SciTech Connect

    Hutton, A.; Zisman, M.S.

    1991-05-01

    An Asymmetric B Factory to be installed in the PEP tunnel has been under study at SLAC, LBL and LLNL for several years. A mature design for a 9 GeV {times} GeV electron-positron collider with a design luminosity of 3 {times} 10{sup 33} cm{sup {minus}2}s{sup {minus}1} is presented. Solutions new exist for all the technical problems, including issues rlated high currents (e.g. beam instabilities, feedback systems, vacuum chamber design, lifetime degradation and radiation power dissipation in the interaction region) and those related to the related to the different energies of the beams (e.g. beam separation, beam -- beam interaction and detector requirements). The status of the design, including prototype development will be discussed.

  8. Particle identification at an asymmetric B Factory

    SciTech Connect

    Coyle, P.; Eigen, G.; Hitlin, D.; Oddone, P.; Ratcliff, B.; Roe, N.; Va'vra, J.; Ypsilantis, T.

    1991-09-01

    Particle identification systems are an important component of any detector at a high-luminosity, asymmetric B Factory. In particular, excellent hadron identification is required to probe CP violation in B{sup 0} decays to CP eigenstates. The particle identification systems discussed below also provide help in separating leptons from hadrons at low momenta. We begin this chapter with a discussion of the physics motivation for providing particle identification, the inherent limitations due to interactions and decays in flight, and the requirements for hermiticity and angular coverage. A special feature of an asymmetric B Factory is the resulting asymmetry in the momentum distribution as a function of polar angle; this will also be quantified and discussed. In the next section the three primary candidates, time-of-flight (TOF), energy loss (dE/dx), and Cerenkov counters, both ring-imaging and threshold, will be briefly described and evaluated. Following this, one of the candidates, a long-drift Cerenkov ring-imaging device, is described in detail to provide a reference design. Design considerations for a fast RICH are then described. A detailed discussion of aerogel threshold counter designs and associated R D conclude the chapter. 56 refs., 64 figs., 13 tabs.

  9. Development of RP UPLC-TOF/MS, stability indicating method for omeprazole and its related substances by applying two level factorial design; and identification and synthesis of non-pharmacopoeial impurities.

    PubMed

    Jadhav, Sushant Bhimrao; Kumar, C Kiran; Bandichhor, Rakeshwar; Bhosale, P N

    2016-01-25

    A new UPLC-TOF/MS compatible, reverse phase-stability indicating method was developed for determination of Omeprazole (OMP) and its related substances in pharmaceutical dosage forms by implementing Design of Experiment (DoE) i.e. two level full factorial Design (2(3)+3 center points=11 experiments) to understand the Critical Method Parameters (CMP) and its relation with Critical Method Attribute (CMA); to ensure robustness of the method. The separation of eleven specified impurities including conversion product of OMP related compound F (13) and G (14) i.e. Impurity-I (1), OMP related compound-I (11) and OMP 4-chloro analog (12) was achieved in a single method on Acquity BEH shield RP18 100 × 2.1 mm, 1.7 μm column, with inlet filter (0.2 μm) using gradient elution and detector wavelength at 305 nm and validated in accordance with ICH guidelines and found to be accurate, precise, reproducible, robust and specific. The drug was found to degrade extensively in heat, humidity and acidic conditions and forms unknown degradation products during stability studies. The same method was used for LC-MS analysis to identify m/z and fragmentation of maximum unknown impurities (Non-Pharmacopoeial) i.e. Impurity-I (1), Impurity-III (3), Impurity-V (5) and Impurity-VIII (9) formed during stability studies. Based on the results, degradation pathway for the drug has been proposed and synthesis of identified impurities i.e. impurities (Impurity-I (1), Impurity-III (3), Impurity-V (5) and Impurity-VIII (9)) are discussed in detail to ensure in-depth understanding of OMP and its related impurities and optimum performance during lifetime of the product. PMID:26600119

  10. A factory concept for processing and manufacturing with lunar material

    NASA Technical Reports Server (NTRS)

    Driggers, G. W.

    1977-01-01

    A conceptual design for an orbital factory sized to process 1.5 million metric tons per year of raw lunar fines into 0.3 million metric tons of manufacturing materials is presented. A conservative approach involving application of present earth-based technology leads to a design devoid of new inventions. Earth based counterparts to the factory machinery were used to generate subsystem masses and lumped parameters for volume and mass estimates. The results are considered to be conservative since technologies more advanced than those assumed are presently available in many areas. Some attributes of potential space processing technologies applied to material refinement and component manufacture are discussed.

  11. The Tau-Charm Factory and tau physics

    SciTech Connect

    Perl, M.L.

    1989-04-01

    An international group of physicists is developing the concept and design of a Tau-Charm Factory: a two-ring, electron-positron, circular collider with 1.5 /< =/ /radical/s /< =/ 4.2 GeV and a design luminosity of 10/sup 33/ cm/sup /minus/2/ s/sup /minus/1/. This paper presents the concept of the facility and outlines the tau lepton physics which can be done. A companion talk by R. Schindler discusses the D/sup 0/, D/sup /+-//, and D/sub s/ physics at a Tau-Charm Factory. 25 refs., 2 tabs.

  12. Beyond Hypermodern Militarized Knowledge Factories

    ERIC Educational Resources Information Center

    Armitage, John

    2005-01-01

    This article is an intervention into and examination of hypermodern forms of militarization or what the author calls "hypermodern militarized knowledge factories," exemplified here by the increasingly militarized universities of North America. He specifies the important arguments of his intervention into the hypermodern militarization of higher…

  13. Rural "Dropout Factories" Often Overshadowed

    ERIC Educational Resources Information Center

    Zehr, Mary Ann

    2010-01-01

    In the foothills of the Appalachian Mountains in the northwest corner of South Carolina, high schools' attempts to curb student dropouts may not match what many people picture when they hear talk of the nation's "dropout factories." Yet one-fifth of the 2,000 high schools nationwide categorized that way by researchers at Johns Hopkins University…

  14. Charm Factories: Present and Future

    NASA Astrophysics Data System (ADS)

    Zweber, Peter

    2009-12-01

    The next generation tau-charm factory, the third Beijing Electron Spectrometer (BESIII) at the new Beijing Electron Positron Collider (BEPCII), has begun data collection. I discuss the flavor physics reach of the BESIII charm program and conclude with a discussion on future proposed tau-charm facilities.

  15. Longitudinal Beam Stability in the SUPER B-FACTORY

    SciTech Connect

    Novokhatski, A.; Zobov, M.; /Frascati

    2009-07-06

    We give an overview of wake fields and impedances in a proposed Super B project, which is based on extremely low emittance beams colliding at a large angle with a crab waist transformation. Understanding the effects that wake fields have on the beam is critical for a successful machine operation. We use our combined experience from the operation of the SLAC B-factory and DA{Phi}NE {Phi}-factory to eliminate strong HOM sources and minimize the chamber impedance in the Super B design. Based on a detailed study of the wake fields in this design we have developed a quasi-Green's function for the entire ring that is used to study bunch lengthening and beam stability. In particular, we check the stability threshold using numerical solutions of the Fokker-Plank equation. We also make a comparison of numerical simulations with the bunch lengthening data in the B- factory.

  16. From Neutrino Factory to Muon Collider

    SciTech Connect

    Geer, S.; /Fermilab

    2010-01-01

    Both Muon Colliders and Neutrino Factories require a muon source capable of producing and capturing {Omicron}(10{sup 21}) muons/year. This paper reviews the similarities and differences between Neutrino Factory and Muon Collider accelerator complexes, the ongoing R&D needed for a Muon Collider that goes beyond Neutrino Factory R&D, and some thoughts about how a Neutrino Factory on the CERN site might eventually be upgraded to a Muon Collider.

  17. 27 CFR 40.69 - Factory premises.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Factory premises. 40.69... PROCESSED TOBACCO Qualification Requirements for Manufacturers of Tobacco Products § 40.69 Factory premises. The premises to be used by a manufacturer of tobacco products as his factory may consist of more...

  18. 27 CFR 40.69 - Factory premises.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Factory premises. 40.69... PROCESSED TOBACCO Qualification Requirements for Manufacturers of Tobacco Products § 40.69 Factory premises. The premises to be used by a manufacturer of tobacco products as his factory may consist of more...

  19. 27 CFR 40.69 - Factory premises.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Factory premises. 40.69... PROCESSED TOBACCO Qualification Requirements for Manufacturers of Tobacco Products § 40.69 Factory premises. The premises to be used by a manufacturer of tobacco products as his factory may consist of more...

  20. 27 CFR 40.502 - Factory premises.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Factory premises. 40.502... Tobacco § 40.502 Factory premises. (a) General. The premises used by a manufacturer of processed tobacco... the factory is in more than one building and each building is not identifiable by a separate...

  1. 27 CFR 40.502 - Factory premises.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Factory premises. 40.502... Tobacco § 40.502 Factory premises. (a) General. The premises used by a manufacturer of processed tobacco... the factory is in more than one building and each building is not identifiable by a separate...

  2. From Exam Factories to Communities of Discovery

    ERIC Educational Resources Information Center

    Coffield, Frank; Williamson, Bill

    2011-01-01

    The British current model of education has turned schools into exam factories and further education colleges and universities into skills factories for British industry. In their book, "From Exam Factories to Communities of Discovery: the Democratic Route," the authors offer an alternative way of thinking and talking about education, as well as…

  3. 27 CFR 40.69 - Factory premises.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Factory premises. 40.69... PROCESSED TOBACCO Qualification Requirements for Manufacturers of Tobacco Products § 40.69 Factory premises. The premises to be used by a manufacturer of tobacco products as his factory may consist of more...

  4. 27 CFR 40.69 - Factory premises.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Factory premises. 40.69... PROCESSED TOBACCO Qualification Requirements for Manufacturers of Tobacco Products § 40.69 Factory premises. The premises to be used by a manufacturer of tobacco products as his factory may consist of more...

  5. Sequence Factorial of "g"-Gonal Numbers

    ERIC Educational Resources Information Center

    Asiru, Muniru A.

    2013-01-01

    The gamma function, which has the property to interpolate the factorial whenever the argument is an integer, is a special case (the case "g"?=?2) of the general term of the sequence factorial of "g"-gonal numbers. In relation to this special case, a formula for calculating the general term of the sequence factorial of any…

  6. NEUTRINO FACTORY AND BETA BEAM EXPERIMENTS AND DEVELOPMENT.

    SciTech Connect

    ALBRIGHT, C.; BERG, J.S.; FERNOW, R.; GALLARDO, J.; KAHN, S.; KIRK, H.; ET AL.

    2004-09-21

    The long-term prospects for fully exploring three-flavor mixing in the neutrino sector depend upon an ongoing and increased investment in the appropriate accelerator R&D. Two new concepts have been proposed that would revolutionize neutrino experiments, namely the Neutrino Factory and the Beta Beam facility. These new facilities would dramatically improve our ability to test the three-flavor mixing framework, measure CP violation in the lepton sector, and perhaps determine the neutrino mass hierarchy, and, if necessary, probe extremely small values of the mixing angle {theta}{sub 13}. The stunning sensitivity that could be achieved with a Neutrino Factory is described, together with our present understanding of the corresponding sensitivity that might be achieved with a Beta Beam facility. In the Beta Beam case, additional study is required to better understand the optimum Beta Beam energy, and the achievable sensitivity. Neither a Neutrino Factory nor a Beta Beam facility could be built without significant R&D. An impressive Neutrino Factory R&D effort has been ongoing in the U.S. and elsewhere over the last few years and significant progress has been made towards optimizing the design, developing and testing the required accelerator components, and significantly reducing the cost. The recent progress is described here. There has been no corresponding activity in the U.S. on Beta Beam facility design and, given the very limited resources, there is little prospect of starting a significant U.S. Beta Beam R&D effort in the near future. However, the Beta Beam concept is interesting, and progress on its development in Europe should be followed. The Neutrino Factory R&D program has reached a critical stage in which support is required for two crucial international experiments and a third-generation international design study. If this support is forthcoming, a Neutrino Factory could be added to the Neutrino Community's road map in about a decade.

  7. On KEK B-Factory

    NASA Astrophysics Data System (ADS)

    Sugawara, H.

    2009-07-01

    There are two principles which the management of a research institute like KEK must respect when dealing with such big project as B-Factory. One is the scientific merit of the project and the other is the organizational consideration which includes financial, human, technical and historical elements. Ideally, the two principles are to be fully taken into account. But, in many cases, one or the other is only partially fulfilled due to unavoidable circumstances. The lack of flexibility to respond to all possible situations is more dangerous and may lead to a disaster as in the case of SSC. I will describe the process which lead to the successful construction, operation and physics presentations of KEK B-Factory following faithfully the official records.

  8. An asymmetric B-meson factory at PEP

    SciTech Connect

    Garren, A.; Chattopadhyay, S.; Chin, Y.; Oddone, P.; Zisman, M.S.; Donald, M.; Feldman, G.; Paterson, J.M.; Rees, J.

    1989-03-01

    A preliminary design for a B-factory has been made using asymmetric collisions between positrons in the PEP storage ring and electrons in a new, log-energy ring. The design utilizes small-aperture, permanent-magnet quadrupoles close to the interaction point (IP). Optimization of optical and beam parameters at the IP will be discussed, as well as the lattice design of the interaction region and of the rings. 7 refs., 3 figs., 2 tabs.

  9. WASTEWATER CONTAMINATE REMOVAL FOR GROUNDWATER RECHARGE AT WATER FACTORY 21

    EPA Science Inventory

    This is the second report in a series which describes the performance of Water Factory 21, a 0.66 cu m/s advanced wastewater treatment plant designed to reclaim secondary effluent from a municipal wastewater treatment plant so that it can be used for injection and recharge of a g...

  10. Replicating systems concepts: Self-replicating lunar factory and demonstration

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Automation of lunar mining and manufacturing facility maintenance and repair is addressed. Designing the factory as an automated, multiproduct, remotely controlled, reprogrammable Lunar Manufacturing Facility capable of constructing duplicates of itself which would themselves be capable of further replication is proposed.

  11. Lattice considerations for a tau-charm factory

    SciTech Connect

    Teng, L.C.; Crosbie, E.A.

    1995-06-01

    The magnet lattice appropriate for a tau-charm factory had been studied extensively. Here we discuss two possible simplifying features which make the design, construction, and operation of the machine simpler without sacrificing performance. These two features may be characterized and identified as (a) luminosity optimization in the ``monochromatic`` mode, and (b) chromaticity correction with sextupoles only in the arcs.

  12. Neutrino Factory and Muon Collider Collaboration R and D Program

    SciTech Connect

    Zisman, M.S.

    2000-07-01

    The Neutrino Factory and Muon Collider Collaboration (MC) comprises some 140 scientists and engineers located at U.S. National Laboratories and Universities, and at a number of non-U.S. research institutions. In the past year, the MC R and D program has shifted its focus mainly toward the design issues related to the development of a Neutrino Factory based on a muon storage ring. In this paper the status of the various R and D activities is described, and future plans are outlined.

  13. Endoscopic versus open radial artery harvest and mammario-radial versus aorto-radial grafting in patients undergoing coronary artery bypass surgery: protocol for the 2 × 2 factorial designed randomised NEO trial

    PubMed Central

    2014-01-01

    Background Coronary artery bypass grafting using the radial artery has, since the 1990s, gone through a revival. Observational studies have indicated better long-term patency when using radial arteries. Therefore, radial artery might be preferred especially in younger patients where long time patency is important. During the last 10 years different endoscopic techniques to harvest the radial artery have evolved. Endoscopic radial artery harvest only requires a small incision near the wrist in contrast to open harvest, which requires an incision from the elbow to the wrist. However, it is unknown whether the endoscopic technique results in fewer complications or a graft patency comparable to open harvest. When the radial artery has been harvested, there are two ways to use the radial artery as a graft. One way is sewing it onto the aorta and another is sewing it onto the mammary artery. It is unknown which technique is the superior revascularisation technique. Methods/Design The NEO Trial is a randomised clinical trial with a 2 × 2 factorial design. We plan to randomise 300 participants into four intervention groups: (1) mammario-radial endoscopic group; (2) aorto-radial endoscopic group; (3) mammario-radial open surgery group; and (4) aorto-radial open surgery group. The hand function will be assessed by a questionnaire, a clinical examination, the change in cutaneous sensibility, and the measurement of both sensory and motor nerve conduction velocity at 3 months postoperatively. All the postoperative complications will be registered, and we will evaluate muscular function, scar appearance, vascular supply to the hand, and the graft patency including the patency of the central radial artery anastomosis. A patency evaluation by multi-slice computer tomography will be done at one year postoperatively. We expect the nerve conduction studies and the standardised neurological examinations to be able to discriminate differences in hand function comparing

  14. A 2 × 2 factorial design for the combination therapy of minocycline and remote ischemic perconditioning: efficacy in a preclinical trial in murine thromboembolic stroke model

    PubMed Central

    2014-01-01

    Background After the failure of so many drugs and therapies for acute ischemic stroke, innovative approaches are needed to develop new treatments. One promising strategy is to test combinations of agents in the pre-hospital setting prior to the administration of intravenous tissue plasminogen activator (IV-tPA) and/ or the use of mechanical reperfusion devices in the hospital. Methods We performed a 2 × 2 factorial design preclinical trial where we tested minocycline (MINO), remote ischemic perconditioning (RIPerC) and their combination treatment in a thromboembolic clot model of stroke in mice, without IV-tPA or later treated with IV-tPA at 4 hours post-stroke. Cerebral blood flow (CBF) was measured by laser speckle contrast imaging (LSCI), behavioral outcomes as neurological deficit score (NDS) and adhesive tape removal test, and infarct size measurement were performed at 48 hours post-stroke. Mice within the experimental sets were randomized for the different treatments, and all outcome measures were blinded. Results RIPerC significantly improved CBF as measured by LSCI in both with and without tPA treated mice (P < 0.001). MINO and RIPerC treatment were effective alone at reducing infarct size (p < 0.0001) and improving short-term functional outcomes (p < 0.001) in the tPA and non-tPA treated animals. The combination treatment of MINO and RIPerC significantly reduced the infarct size greater than either intervention alone (p < 0.05). There were trends in favor of improving functional outcomes after combination treatment of MINO and RIPerC; however combination treatment group was not significantly different than the individual treatments of MINO and RIPerC. There was no “statistical” interaction between minocycline and RIPerC treatments indicating that the effects of RIPerC and MINO were additive and not synergistic on the outcome measures. Conclusion In the future, combining these two safe and low cost interventions in the ambulance

  15. Gearing up to the factory of the future

    NASA Astrophysics Data System (ADS)

    Godfrey, D. E.

    1985-01-01

    The features of factories and manufacturing techniques and tools of the near future are discussed. The spur to incorporate new technologies on the factory floor will originate in management, who must guide the interfacing of computer-enhanced equipment with traditional manpower, materials and machines. Electronic control with responsiveness and flexibility will be the key concept in an integrated approach to processing materials. Microprocessor controlled laser and fluid cutters add accuracy to cutting operations. Unattended operation will become feasible when automated inspection is added to a work station through developments in robot vision. Optimum shop management will be achieved through AI programming of parts manufacturing, optimized work flows, and cost accounting. The automation enhancements will allow designers to affect directly parts being produced on the factory floor.

  16. A Survey of Small Factories*

    PubMed Central

    Jefferys, Margot; Wood, C. H.

    1960-01-01

    This survey was undertaken by a group of doctors, nurses, and lecturers in the Department of Public Health of the London School of Hygiene and Tropical Medicine as part of the teaching programme for the Diploma in Public Health. Fifty small factories in an area of a metropolitan borough were invited to answer questions concerning their industrial processes, their labour force, their premises, their first-aid provision, and the visits they received from officials of local and central government. Forty-eight of these factories responded and observations were made by teams of three recording independently of each other in 45. A variety of industries was represented in these 48 firms, half of which employed less than 10 workers. The working environment, in respect of sanitary arrangements, cleanliness and tidiness, lighting on stairs and passage ways, was considered to be unsatisfactory in many firms. Some instances of inadequate safeguards of machines were seen. The accident rate was found to be rather less than the computed national rate for manufacturing industry in 1956. First-aid equipment and workers were also considered to be deficient in a number of instances. In case of accident and for the treatment of minor ailments most firms made use of a local casualty and out-patient department of a general hospital. This service was considered quite adequate. Many firms had not been visited by the Factory Inspector or his deputy during the previous year. Rather more had received visits from the local authority health inspectors. Many firms expressed confusion about the duties and functions of their various official visitors. The conclusions drawn from this limited enquiry were that the working conditions in small factories are often unsatisfactory; that in areas such as the one surveyed it is unrealistic to think in terms of development of an industrial health service similar to those operating in Slough and Harlow; and that the greatest impact on environmental

  17. Black holes as antimatter factories

    NASA Astrophysics Data System (ADS)

    Bambi, Cosimo; Dolgov, Alexander D.; Petrov, Alexey A.

    2009-09-01

    We consider accretion of matter onto a low mass black hole surrounded by ionized medium. We show that, because of the higher mobility of protons than electrons, the black hole would acquire positive electric charge. If the black hole's mass is about or below 1020 g, the electric field at the horizon can reach the critical value which leads to vacuum instability and electron-positron pair production by the Schwinger mechanism. Since the positrons are ejected by the emergent electric field, while electrons are back-captured, the black hole operates as an antimatter factory which effectively converts protons into positrons.

  18. A plant factory for moth pheromone production.

    PubMed

    Ding, Bao-Jian; Hofvander, Per; Wang, Hong-Lei; Durrett, Timothy P; Stymne, Sten; Löfstedt, Christer

    2014-01-01

    Moths depend on pheromone communication for mate finding and synthetic pheromones are used for monitoring or disruption of pheromone communication in pest insects. Here we produce moth sex pheromone, using Nicotiana benthamiana as a plant factory, by transient expression of up to four genes coding for consecutive biosynthetic steps. We specifically produce multicomponent sex pheromones for two species. The fatty alcohol fractions from the genetically modified plants are acetylated to mimic the respective sex pheromones of the small ermine moths Yponomeuta evonymella and Y. padella. These mixtures are very efficient and specific for trapping of male moths, matching the activity of conventionally produced pheromones. Our long-term vision is to design tailor-made production of any moth pheromone component in genetically modified plants. Such semisynthetic preparation of sex pheromones is a novel and cost-effective way of producing moderate to large quantities of pheromones with high purity and a minimum of hazardous waste. PMID:24569486

  19. Naval Aircraft Factory (Curtiss) H-16

    NASA Technical Reports Server (NTRS)

    1929-01-01

    Naval Aircraft Factory (Curtiss) H-16: The Naval Aircraft Factory H-16 flying boat, seen here on a beaching dolly on the Langley seaplane ramp, was one of 150 built by the Naval Aircraft Factory in Philadelphia, Pennsylvania. Most H-16s built were made by Curtiss, so the type is more readily known under that name. The NACA performed hull pressure distribution tests at Langley during 1929.

  20. Fluid Lavage of Open Wounds (FLOW): design and rationale for a large, multicenter collaborative 2 × 3 factorial trial of irrigating pressures and solutions in patients with open fractures

    PubMed Central

    2010-01-01

    Background Open fractures frequently result in serious complications for patients, including infections, wound healing problems, and failure of fracture healing, many of which necessitate subsequent operations. One of the most important steps in the initial management of open fractures is a thorough wound irrigation and debridement to remove any contaminants. There is, however, currently no consensus regarding the optimal approach to irrigating open fracture wounds during the initial operative procedure. The selection of both the type of irrigating fluid and the pressure of fluid delivery remain controversial. The primary objective of this study is to investigate the effects of irrigation solutions (soap vs. normal saline) and pressure (low vs. high; gravity flow vs. high; low vs. gravity flow) on re-operation within one year among patients with open fractures. Methods/Design The FLOW study is a multi-center, randomized controlled trial using a 2 × 3 factorial design. Surgeons at clinical sites in North America, Europe, Australia, and Asia will recruit 2 280 patients who will be centrally randomized into one of the 6 treatment arms (soap + low pressure; soap + gravity flow pressure; soap + high pressure; saline + low pressure; saline + gravity flow pressure; saline + high pressure). The primary outcome of the study is re-operation to promote wound or bone healing, or to treat an infection. This composite endpoint of re-operation includes a narrow spectrum of patient-important procedures: irrigation and debridement for infected wound, revision and closure for wound dehiscence, wound coverage procedures for infected or necrotic wound, bone grafts or implant exchange procedures for established nonunion in patients with postoperative fracture gaps less than 1 cm, intramedullary nail dynamizations in the operating room, and fasciotomies for compartment syndrome. Patients, outcome adjudicators, and data analysts will be blinded. We will compare rates of re-operation at

  1. Optimization of water treatment methods for the purification of peat extraction derived runoff: Evaluation of chemical treatment response to variations in incoming water quality using a 2k factorial test design

    NASA Astrophysics Data System (ADS)

    Heiderscheidt, Elisangela; Ronkanen, Anna-Kaisa; Klöve, Björn

    2013-04-01

    environmental impacts related to this treatment method. The influence of variations in water quality parameters was accessed using a 2k factorial test design and a well-known chemical purification pilot test procedure (jar test). The k factors or parameters evaluated were: organic matter as chemical oxygen demand (COD 20mg/l and 80mg/l), suspended solids (SS 10mg/l and 60 mg/l), applied coagulant dosage (ferric sulphate 35mg/l and 100mg/l) as well as pH (4.5 and 7.0). Water samples were collected from different peat extraction sites and suitable samples were manipulated using techniques such as centrifugation, dilution and acid or base addition to produce samples with the combinations of high and low concentrations presented. The complete statistical analysis of obtained results will include evaluation of variability using the univariate repeated measures ANOVA as well as the multivariate repeated measures ANOVA methods. Preliminary results of the univariate analyses shows that the interaction between the concentration of a particular substance (COD, SS and pH) and the dosage applied impose significant higher influence on the overall purification efficiency than the substance concentration and applied dosage as individual factors.

  2. Implementation of China`s three synchronizations policy: Case studies of wastewater treatment measures at new and renovated factories

    SciTech Connect

    Sinkule, B.J.

    1994-03-01

    The Three Synchronizations Policy requires that the design, construction, and operation of a new factory, or an existing factory that expands or changes production processes, be synchronized with the design, construction and operation of appropriate waste treatment facilities. Under this policy, when a new factory is designed, wastewater treatment facilities must be included as part of the overall factory design: when the factory is constructed, the wastewater treatment facilities must be constructed along with construction of the production facilities; and finally, when the factory begins to operate, the waste treatment facilities must begin operation as well. This research includes case studies of wastewater treatment measures at sixteen factories in the Pearl River Delta Region of China. Implementation of the Three Synchronizations Policy is examined in detail for two of the factories: Fengfu Weaving and Dyeing Plant and Zhongguan Printing and Dyeing Plant. The results of this research suggest that the Three Synchronizations Policy has been an effective means of forcing new and renovated factories to comply with wastewater discharge standards, mainly because the Three Synchronizations Policy gives environmental protection bureaus authority to regulate at each step of a new industrial facility`s development. In practice, this authority has been exercised through formalizing the {open_quotes}synchronizations{close_quotes} into a management system with specific regulatory requirements, each of which requires EPB approval. EPBs ran stall operation by withholding its approval of certification of a factory`s wastewater treatment facilities; EPBs also use fines and limited time treatment orders to enforce the Three Synchronizations Policy. The research results demonstrate that the Three Synchronizations Policy was more important than the Pollutant Discharge Fee Program in motivating existing factories to build wastewater treatment facilities.

  3. Agile manufacturing: The factory of the future

    NASA Technical Reports Server (NTRS)

    Loibl, Joseph M.; Bossieux, Terry A.

    1994-01-01

    The factory of the future will require an operating methodology which effectively utilizes all of the elements of product design, manufacturing and delivery. The process must respond rapidly to changes in product demand, product mix, design changes or changes in the raw materials. To achieve agility in a manufacturing operation, the design and development of the manufacturing processes must focus on customer satisfaction. Achieving greatest results requires that the manufacturing process be considered from product concept through sales. This provides the best opportunity to build a quality product for the customer at a reasonable rate. The primary elements of a manufacturing system include people, equipment, materials, methods and the environment. The most significant and most agile element in any process is the human resource. Only with a highly trained, knowledgeable work force can the proper methods be applied to efficiently process materials with machinery which is predictable, reliable and flexible. This paper discusses the affect of each element on the development of agile manufacturing systems.

  4. 27 CFR 40.114 - Extension or curtailment of factory.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of factory. 40.114 Section 40.114 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... Products Changes in Location of Factory § 40.114 Extension or curtailment of factory. Where a tobacco products factory is to be changed to an extent which will make inaccurate the description of the factory...

  5. 27 CFR 40.114 - Extension or curtailment of factory.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of factory. 40.114 Section 40.114 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... Products Changes in Location of Factory § 40.114 Extension or curtailment of factory. Where a tobacco products factory is to be changed to an extent which will make inaccurate the description of the factory...

  6. 27 CFR 40.114 - Extension or curtailment of factory.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... factory. 40.114 Section 40.114 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Products Changes in Location of Factory § 40.114 Extension or curtailment of factory. Where a tobacco products factory is to be changed to an extent which will make inaccurate the description of the factory...

  7. 27 CFR 40.114 - Extension or curtailment of factory.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of factory. 40.114 Section 40.114 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... Products Changes in Location of Factory § 40.114 Extension or curtailment of factory. Where a tobacco products factory is to be changed to an extent which will make inaccurate the description of the factory...

  8. 27 CFR 40.114 - Extension or curtailment of factory.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of factory. 40.114 Section 40.114 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... Products Changes in Location of Factory § 40.114 Extension or curtailment of factory. Where a tobacco products factory is to be changed to an extent which will make inaccurate the description of the factory...

  9. Options for Production Staging for a Low Energy Neutrino Factory

    SciTech Connect

    Berg J. S.

    2011-10-26

    A low energy neutrino factory (LENF) is defined, for the purpose of this report, to accelerate a muon beam to a total energy in the range of 10-14 GeV, and store it in a decay ring directing a resulting neutrino beam to a detector 2200-2300 km distant. The machine should be ultimately capable of producing 10{sup 21} decays toward that detector per year of 10{sup 7} s. We consider such a neutrino factory to be the accelerator defined in the Interim Design Report (IDR) of the International Design Study for the Neutrino Factory (IDS-NF), modified to remove the final stage of acceleration, possibly modifying the remaining acceleration stages to adjust the final energy, and replacing the decay ring with one designed for the lower energy and shorter baseline. We discuss modifications to that design which would reduce the cost of the machine at the price of a reduction in neutrino production, down to as low as 10{sup 20} decays per year. These modifications will not preclude eventually upgrading the machine to the full production of 10{sup 21} decays per year. The eventual cost of a machine which achieves the full production through a series of lower-production stages should not exceed the cost of a machine which is immediately capable of the full production by more than a small fraction of the cost difference between the full production machine and the lowest production stage.

  10. Choice of Proton Driver Parameters for a Neutrino Factory

    SciTech Connect

    Kirk,H.G.; Berg, J. S.; Fernow, R. C.; Gallardo, J. C.; Simos, N.; Weng, W.-T.; Brooks, S.

    2006-06-26

    We discuss criteria for designing an optimal 'green field' proton driver for a neutrino factory. The driver parameters are determined by considerations of space charge, power capabilities of the target, beam loading and available RF peak power. A neutrino factory may be the best experimental tool to unravel the physics involved in neutrino oscillation and CP violation phenomena [1]. To have sufficient neutrino flux for acceptable physics results within 5 years requires about 10{sup 22} protons on target per year, which corresponds to 1-4 MW of proton beam power from the proton driver depending on the beam energy. In the past, there were individual proposals from different laboratories of a particular design of proton driver capable of delivering beam power from 2 to 4 MW, without consistent attention paid to the needs or requirements from the downstream systems. In this study, we try to identify the requirements from those down stream systems first, then see whether it is possible to design a proton driver to meet those needs. Such a study will also assist site specific proposals to further improve on their designs to better serve the need of a proton driver for neutrino factory applications.

  11. Douglas DT-2 (Naval Aircraft Factory

    NASA Technical Reports Server (NTRS)

    1923-01-01

    Douglas DT-2 (Naval Aircraft Factory): This example of the Douglas DT-2 torpedo plane, which flew as 'NACA 11,' was built in Philadelphia, Pennsylvania by the Naval Aircraft Factory. Langley's NACA staff studied the take-off characteristics of a twin-float seaplane with this aircraft.

  12. A Tau-Charm Factory at CEBAF

    SciTech Connect

    Seth, K.K.

    1994-04-01

    It is proposed that a Tau Charm Factory represents a natural extension of CEBAF into higher energy domains. The exciting nature of the physics of charm quarks and tau leptons is briefly reviewed and it is suggested that the concept of a linac-ring collider as a Tau Charm Factory at CEBAF should be seriously studied.

  13. The Operator Guide: An Ambient Persuasive Interface in the Factory

    NASA Astrophysics Data System (ADS)

    Meschtscherjakov, Alexander; Reitberger, Wolfgang; Pöhr, Florian; Tscheligi, Manfred

    In this paper we introduce the context of a semiconductor factory as a promising area for the application of innovative interaction approaches. In order to increase efficiency ambient persuasive interfaces, which influence the operators' behaviour to perform in an optimized way, could constitute a potential strategy. We present insights gained from qualitative studies conducted in a specific semiconductor factory and provide a description of typical work processes and already deployed interfaces in this context. These findings informed the design of a prototype of an ambient persuasive interface within this realm - the "Operator Guide". Its overall aim is to improve work efficiency, while still maintaining a minimal error rate. We provide a detailed description of the Operator Guide along with an outlook of the next steps within a user-centered design approach.

  14. R&D Toward Neutrino Factories and Muon Colliders

    SciTech Connect

    Zisman, Michael S.

    2003-06-24

    R&D aimed at the production, acceleration, and storage of intense muon beams is under way in the U.S., in Europe, and in Japan. Considerable progress has been made in the past few years toward the design of a ''Neutrino Factory'' in which a beam of 20-50 GeV mu- or mu+ is stored. Decay neutrinos from the beam illuminate a detector located roughly 3000 km from the ring. Here, we briefly describe the ingredients of a Neutrino Factory and then discuss the current R&D program and its results. A key concept in the design is ''ionization cooling,'' a process whereby the muon emittance is reduced by repeated interactions with an absorber material followed by reacceleration with high-gradient rf cavities. Plans to test this concept in the Muon Ionization Cooling Experiment (MICE) are well along and are described briefly.

  15. Feedback implementation options and issues for B factory accelerators

    SciTech Connect

    Fox, J.D.; Briggs, D.; Eisen, N.; Hindi, H.; Hosseini, W.; Oxoby, G. ); Linscott, I. ); Coiro, O.; Ghigo, A.; Serio, M. . Lab. Nazionale di Frascati); Lambertson, G.; Voelker, F. . Lawrence Berkeley Lab

    1992-09-01

    The proposed B factory accelerator facilities will require active feedback systems to control multibunch instabilities. These feedback systems must operate in machines with thousands of circulating bunches and with short (2--4 ns) interbunch intervals. The functional requirements for transverse (betatron) and longitudinal (synchrotron) feedback systems are presented. Several possible implementation options are discussed and system requirements developed. Conceptual designs are presented for the PEP II transverse and longitudinal feedback systems.

  16. 4. SOUTHEAST CORNER OF EDIBLE FATS FACTORY (CONNECTING BUILDING ON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. SOUTHEAST CORNER OF EDIBLE FATS FACTORY (CONNECTING BUILDING ON THE LEFT) - Wilson's Oil House, Lard Refinery, & Edible Fats Factory, Edible Fats Factory, 2801 Southwest Fifteenth Street, Oklahoma City, Oklahoma County, OK

  17. 1. VIEW TO SOUTHEAST (NORTHWEST CORNER OF EDIBLE FATS FACTORY) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW TO SOUTHEAST (NORTHWEST CORNER OF EDIBLE FATS FACTORY) - Wilson's Oil House, Lard Refinery, & Edible Fats Factory, Edible Fats Factory, 2801 Southwest Fifteenth Street, Oklahoma City, Oklahoma County, OK

  18. 3. VIEW TO SOUTHWEST (NORTHEAST CORNER OF EDIBLE FATS FACTORY) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW TO SOUTHWEST (NORTHEAST CORNER OF EDIBLE FATS FACTORY) - Wilson's Oil House, Lard Refinery, & Edible Fats Factory, Edible Fats Factory, 2801 Southwest Fifteenth Street, Oklahoma City, Oklahoma County, OK

  19. 1. VIEW OF NORTHWEST FRONT OF FACTORY BUILDING. THE OFFICE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW OF NORTHWEST FRONT OF FACTORY BUILDING. THE OFFICE BUILDING IS ON THE LEFT AND 2201-2299 WAREHOUSE IS ON THE RIGHT, FACING SOUTHWEST. - Savage Tire Factory, Factory Building, 2301 Main Street, San Diego, San Diego County, CA

  20. 4. VIEW OF THE SOUTHEAST ELEVATION OF THE FACTORY BUILDING. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW OF THE SOUTHEAST ELEVATION OF THE FACTORY BUILDING. THE SOUTHEAST ELEVATION OF THE OFFICE BUILDING IS ON THE RIGHT. - Savage Tire Factory, Factory Building, 2301 Main Street, San Diego, San Diego County, CA

  1. 6. FACTORY BUILDING, WITH FINISHED PRODUCT WAREHOUSE IN RIGHT BACKGROUND. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. FACTORY BUILDING, WITH FINISHED PRODUCT WAREHOUSE IN RIGHT BACKGROUND. VIEW TO NORTHWEST. - Commercial & Industrial Buildings, Maizewood Insulation Company Factory, 275 Salina Street, Dubuque, Dubuque County, IA

  2. A reference architecture for the component factory

    NASA Technical Reports Server (NTRS)

    Basili, Victor R.; Caldiera, Gianluigi; Cantone, Giovanni

    1992-01-01

    Software reuse can be achieved through an organization that focuses on utilization of life cycle products from previous developments. The component factory is both an example of the more general concepts of experience and domain factory and an organizational unit worth being considered independently. The critical features of such an organization are flexibility and continuous improvement. In order to achieve these features we can represent the architecture of the factory at different levels of abstraction and define a reference architecture from which specific architectures can be derived by instantiation. A reference architecture is an implementation and organization independent representation of the component factory and its environment. The paper outlines this reference architecture, discusses the instantiation process, and presents some examples of specific architectures by comparing them in the framework of the reference model.

  3. Spacecraft factory-to-pad testing concept

    NASA Technical Reports Server (NTRS)

    Jones, R. H.

    1975-01-01

    It is noted that the concept of factory-to-pad testing is based on the shipment of a flight-ready spacecraft to the launch base and can be achieved by thorough and comprehensive factory testing of the spacecraft. The principal objectives and results of this approach are shown to be significant cost reductions, increased test effectiveness, and fewer flight problems. Key elements for this concept's success are discussed, including factory-to-pad commonality of support equipment, test requirements and procedures, test teams, and computer programs. Applications of this approach in the space-shuttle era are considered, and a preliminary factory-to-pad concept for the Large Space Telescope spacecraft is presented.

  4. Verbal and Nonverbal Communication of Factory Workers

    ERIC Educational Resources Information Center

    Tway, Patricia

    1976-01-01

    Examines the verbal and nonverbal behavior patterns associated with two speech styles, one formal and the other informal, among factory workers. Available from: Mouton Publishers, Box 482, the Hague, Netherlands. (AM)

  5. The Physics of the B Factories

    DOE PAGESBeta

    Bevan, A. J.

    2014-11-19

    This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C.

  6. Riken RI Beam Factory, Harvest Time

    NASA Astrophysics Data System (ADS)

    En'yo, H.

    2015-06-01

    At RIKEN RI Beam Factory (RIBF), having all the experimental facilities in place, the uranium-beam intensity recorded 25pnA in 2014. With use of this powerful beam many experiments are begin performed by variety of researchers from all over the world, producing a lot of new data which were just a dream in several years ago. Recent status of RIKEN RI Beam Factory (RIBF) is presented with future prospects in science and an accelerator plan.

  7. Factory floor injury in a Lagos sawmill.

    PubMed

    Bode, C O; Giwa, S O; Oke, D A

    2001-01-01

    We retrospectively reviewed injuries sustained in 36 consecutive accidents in a wood-processing factory and managed at a private hospital over a 2-year period in Lagos. The commonest injuries were lacerations by revolving saws, followed by crush injuries from entrapment by machines and from falling logs and planks. The upper limbs were involved in 24 (66%) of these accidents cases. Of 137 workers on the factory floor, the highest injury rate (64%) occurred among machine operators. While 80.6% of these injuries were simple ones treated by suturing and dressing, 7 (19.4%) were life-threatening enough to warrant hospitalisation and major surgery, with 6 sustaining a mean permanent disability of 7.1 +/- 6%. Although factory-floor injuries constituted only 6.5% of 553 hospital attendance recorded within the period from the company, they were responsible for 44.2% of total medical expenditure by the company within the same period. Non-use of protective gears and disregard for safety procedures were noted in most of the accidents. The in-house first-aid program was adjudged as life-saving in the few major cases managed. We concluded that while many factory-floor injuries in wood-processing factories may be minor hand injuries, provision and strict observance of safety protocols as well as an active first-aid program are invaluable to minimise morbidity, cost and loss of productive man-hours in wood processing factories. PMID:11885883

  8. RF cavity development for the PEP-II B factory

    SciTech Connect

    Rimmer, R.A.

    1992-11-01

    This paper describes the development of an RF cavity design for the proposed PEP-II asymmetric B factory. The high luminosity required of PEP-II provides challenges in the design of the RF cavities, most notably in the reduced higher-order mode (HOM) impedances that must be attained and in the power that must be dissipated in the cavity walls. This paper outlines the goals set in these regards, describes how the cavity has been developed to meet them, and presents the results of measurements on a low-power test model built to verify the HOM damping scheme.

  9. Interaction region considerations for a B-factory

    SciTech Connect

    DeStaebler, H.

    1990-07-01

    The goal of the project is to observe CP violation in the {bar B}B system. This machine is supposed to be a factory for high energy physics, not an R D project for accelerator physics. There are a number of interrelated design issues arising from the different desires of the detector and the machine, some of which are listed in this paper. A number of background and beampipe issues are mentioned. The emphasis is on calculations. Any satisfactory design will combine measurements on existing machines with calculations pertaining to the measurement conditions as well as to the proposed machine. 57 refs.

  10. 27 CFR 40.254 - Receipt into factory.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Receipt into factory. 40... Operations § 40.254 Receipt into factory. A manufacturer of tobacco products may receive in bond into his factory tobacco products and may also receive into his factory tobacco products on which the tax has...

  11. 27 CFR 40.254 - Receipt into factory.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Receipt into factory. 40... Operations § 40.254 Receipt into factory. A manufacturer of tobacco products may receive in bond into his factory tobacco products and may also receive into his factory tobacco products on which the tax has...

  12. 27 CFR 40.254 - Receipt into factory.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Receipt into factory. 40... Operations § 40.254 Receipt into factory. A manufacturer of tobacco products may receive in bond into his factory tobacco products and may also receive into his factory tobacco products on which the tax has...

  13. 27 CFR 40.254 - Receipt into factory.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Receipt into factory. 40... Operations § 40.254 Receipt into factory. A manufacturer of tobacco products may receive in bond into his factory tobacco products and may also receive into his factory tobacco products on which the tax has...

  14. 27 CFR 40.254 - Receipt into factory.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Receipt into factory. 40... Operations § 40.254 Receipt into factory. A manufacturer of tobacco products may receive in bond into his factory tobacco products and may also receive into his factory tobacco products on which the tax has...

  15. Where is the ooid factory?

    NASA Astrophysics Data System (ADS)

    Mariotti, G.; Pruss, S. B.; klepac-Ceraj, V.; Summons, R. E.; Newman, S. A.; Bosak, T.

    2014-12-01

    Ooids, concentrically laminated carbonate grains, are found in high-energy shallow water environments (the ooid factory). Consequently, ooid laminae are thought to precipitate around suspended grains. The role of microbes in this process is debated: abiotic models neither explain how ooids acquire a high organic content, nor do they account for the fast abrasion and loss of ooid carbonate in highly agitated areas. Here we probe the role of microbes and physical processes in ooid accretion on an oolitic beach in the leeward coast of Cat Island, the Bahamas. Grain size and petrography, microbial community composition and physical factors are compared along a cross-shore transect. A hydro-morphodynamic model is used to analyze sediment transport and sorting across the beach and shallow shelf. We find that the surf zone has a barren seafloor, and it is dominated by shiny and rounded ooids whose size decreases seaward, as predicted by physical grain sorting. Dull ooids and grapestones, irregular coated grains that are thought to form by microbially-mediated precipitation of carbonate around ooids and other grains, are present outside of the surf zone. The bulk size of these grains increases seaward, and they contain more abundant and diverse microbial communities than agitated ooids. The inverted sorting trend indicates that the time scale for grain accretion in this region is shorter than the decadal time scale for grain sorting. Modeling and field observations suggest that carbonate precipitation of both ooids and grapestones occurs in sediments that are colonized by diatom- and cyanobacteria-rich mats and reworked during storms. Periodic storms transport ooids to the surf zone, where they are rounded by abrasion and gain a shiny exterior in less than a day of reworking. Small ooids are periodically transported back to the microbially colonized areas, and the accretion cycle restarts. Grains too large to be frequently transported exit the accretion-erosion conveyor

  16. Metabolic modelling in the development of cell factories by synthetic biology

    PubMed Central

    Jouhten, Paula

    2012-01-01

    Cell factories are commonly microbial organisms utilized for bioconversion of renewable resources to bulk or high value chemicals. Introduction of novel production pathways in chassis strains is the core of the development of cell factories by synthetic biology. Synthetic biology aims to create novel biological functions and systems not found in nature by combining biology with engineering. The workflow of the development of novel cell factories with synthetic biology is ideally linear which will be attainable with the quantitative engineering approach, high-quality predictive models, and libraries of well-characterized parts. Different types of metabolic models, mathematical representations of metabolism and its components, enzymes and metabolites, are useful in particular phases of the synthetic biology workflow. In this minireview, the role of metabolic modelling in synthetic biology will be discussed with a review of current status of compatible methods and models for the in silico design and quantitative evaluation of a cell factory. PMID:24688669

  17. Design and Organization of the Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT) Trial: a factorial trial evaluating the effects of corticosteroids, glucose control, and depth-of-anesthesia on perioperative inflammation and morbidity from major non-cardiac surgery

    PubMed Central

    2010-01-01

    Background The perioperative period is characterized by an intense inflammatory response. Perioperative inflammation promotes postoperative morbidity and increases mortality. Blunting the inflammatory response to surgical trauma might thus improve perioperative outcomes. We are studying three interventions that potentially modulate perioperative inflammation: corticosteroids, tight glucose control, and light anesthesia. Methods/Design The DeLiT Trial is a factorial randomized single-center trial of dexamethasone vs placebo, intraoperative tight vs. conventional glucose control, and light vs deep anesthesia in patients undergoing major non-cardiac surgery. Anesthetic depth will be estimated with Bispectral Index (BIS) monitoring (Aspect medical, Newton, MA). The primary outcome is a composite of major postoperative morbidity including myocardial infarction, stroke, sepsis, and 30-day mortality. C-reactive protein, a measure of the inflammatory response, will be evaluated as a secondary outcome. One-year all-cause mortality as well as post-operative delirium will be additional secondary outcomes. We will enroll up to 970 patients which will provide 90% power to detect a 40% reduction in the primary outcome, including interim analyses for efficacy and futility at 25%, 50% and 75% enrollment. Discussion The DeLiT trial started in February 2007. We expect to reach our second interim analysis point in 2010. This large randomized controlled trial will provide a reliable assessment of the effects of corticosteroids, glucose control, and depth-of-anesthesia on perioperative inflammation and morbidity from major non-cardiac surgery. The factorial design will enable us to simultaneously study the effects of the three interventions in the same population, both individually and in different combinations. Such a design is an economically efficient way to study the three interventions in one clinical trial vs three. Trial registration This trial is registered at Clinicaltrials

  18. Baby factories taint surrogacy in Nigeria.

    PubMed

    Makinde, Olusesan Ayodeji; Makinde, Olufunmbi Olukemi; Olaleye, Olalekan; Brown, Brandon; Odimegwu, Clifford O

    2016-01-01

    The practice of reproductive medicine in Nigeria is facing new challenges with the proliferation of 'baby factories'. Baby factories are buildings, hospitals or orphanages that have been converted into places for young girls and women to give birth to children for sale on the black market, often to infertile couples, or into trafficking rings. This practice illegally provides outcomes (children) similar to surrogacy. While surrogacy has not been well accepted in this environment, the proliferation of baby factories further threatens its acceptance. The involvement of medical and allied health workers in the operation of baby factories raises ethical concerns. The lack of a properly defined legal framework and code of practice for surrogacy makes it difficult to prosecute baby factory owners, especially when they are health workers claiming to be providing services to clients. In this environment, surrogacy and other assisted reproductive techniques urgently require regulation in order to define when ethico-legal lines have been crossed in providing surrogacy or surrogacy-like services. PMID:26602942

  19. The Factory Approach to Creating TSTT Meshes

    SciTech Connect

    Epperly, T

    2003-10-21

    The factory approach (a.k.a. virtual constructor) hides the details of the class implementing the TSTT from TSTT users. In version 0.5 of TSTT.sidl, the client hard codes the name of the implementing class into their code. The client is forced to choose from the small set of possible concrete classes defined in TSTT.sidl. This approach makes it impossible to support multiple implementations of the TSTT in a single process because each implementation has to implement the same class. The factory approach hides the details of mesh creation from the client. The client does not need to know the name of the implementing class, and the client can dynamically determine which interfaces are supported by the new mesh. A factory can support multiple TSTT implementation because each implementation defines its own concrete classes to implement. The factory approach does require the TSTT compliant mesh packages to implement a MeshFactory interface, and everyone needs to link against an implementation of the Registry. The Registry only has 7 methods that are fairly easy to implement, and everyone can share one implementation of the Registry.

  20. A Simple Parameterization of 3 x 3 Magic Squares

    ERIC Educational Resources Information Center

    Trenkler, Gotz; Schmidt, Karsten; Trenkler, Dietrich

    2012-01-01

    In this article a new parameterization of magic squares of order three is presented. This parameterization permits an easy computation of their inverses, eigenvalues, eigenvectors and adjoints. Some attention is paid to the Luoshu, one of the oldest magic squares.

  1. DKIST enclosure modeling and verification during factory assembly and testing

    NASA Astrophysics Data System (ADS)

    Larrakoetxea, Ibon; McBride, William; Marshall, Heather K.; Murga, Gaizka

    2014-08-01

    The Daniel K. Inouye Solar Telescope (DKIST, formerly the Advanced Technology Solar Telescope, ATST) is unique as, apart from protecting the telescope and its instrumentation from the weather, it holds the entrance aperture stop and is required to position it with millimeter-level accuracy. The compliance of the Enclosure design with the requirements, as of Final Design Review in January 2012, was supported by mathematical models and other analyses which included structural and mechanical analyses (FEA), control models, ventilation analysis (CFD), thermal models, reliability analysis, etc. During the Enclosure Factory Assembly and Testing the compliance with the requirements has been verified using the real hardware and the models created during the design phase have been revisited. The tests performed during shutter mechanism subsystem (crawler test stand) functional and endurance testing (completed summer 2013) and two comprehensive system-level factory acceptance testing campaigns (FAT#1 in December 2013 and FAT#2 in March 2014) included functional and performance tests on all mechanisms, off-normal mode tests, mechanism wobble tests, creation of the Enclosure pointing map, control system tests, and vibration tests. The comparison of the assumptions used during the design phase with the properties measured during the test campaign provides an interesting reference for future projects.

  2. The Australian diffractometer at the Photon Factory

    SciTech Connect

    Barnea, Z. ); Creagh, D.C. ); Davis, T.J. ); Garrett, R.F. ); Janky, S.; Stevenson, A.W.; Wilkins, S.W. )

    1992-01-01

    Outlined are design features of a versatile high-resolution two-axis diffractometer that is being constructed for operation at the Photon Factory as an Australian national facility. The instrument features optional use of multiple-imaging plates on a translating cassette to allow rapid recording of an almost complete range of data covering both the high-angle and small-angle scattering regime or alternatively the use of electronic detectors. The instrument will be capable of operation in various modes including the following: (i) high-resolution powder diffraction with single-channel counter and crystal analyzer, (ii) high-resolution, high-speed powder diffraction in the Debye--Scherrer mode with imaging plates as recording medium, either stationary or translating (for time-dependent studies), (iii) small-angle x-ray scattering with imaging plates as recording medium, (iv) protein crystallography in screenless Weissenberg mode, and (v) two- or three-axis single-crystal diffractometry. The salient features of the instrument are the use of a double-crystal sagittal focusing monochromator as primary monochromator together with the optional use of a condensing--collimating channel-cut (CCCC) monochromator or other channel-cut monochromator as secondary monochromator. The use of a CCCC monochromator enables fine tuning of beam position on sample, harmonic suppression, beam-condensation, and variation of wavelength bandpass. Further features include the use of high-precision incremental encoders on both axes, together with the capability of operating the whole diffractometer, including secondary monochromator and detectors, in vacuum of order 10{sup {minus}3} Torr in order to reduce absorption and parasitic scattering, and the use of a large camera radius (approximately 0.57 m) for the imaging plate cassette in order to increase angular resolution and signal to noise.

  3. Overview of the nearby supernova factory

    SciTech Connect

    Aldering, Greg; Adam, Gilles; Antilogus, Pierre; Astier, Pierre; Bacon, Roland; Bongard, S.; Bonnaud, C.; Copin, Yannick; Hardin, D.; Howell, D. Andy; Lemmonnier, Jean-Pierre; Levy, J.-M.; Loken, S.; Nugent, Peter; Pain, Reynald; Pecontal, Arlette; Pecontal, Emmanuel; Perlmutter, Saul; Quimby, Robert; Schahmaneche, Kyan; Smadja, Gerard; Wood-Vasey, W. Michael

    2002-07-29

    The Nearby Supernova Factory (SNfactory) is an international experiment designed to lay the foundation for the next generation of cosmology experiments (such as CFHTLS, wP, SNAP and LSST) which will measure the expansion history of the Universe using Type Ia supernovae. The SNfactory will discover and obtain frequent lightcurve spectrophotometry covering 3200-10000 {angstrom} for roughly 300 Type Ia supernovae at the low-redshift end of the smooth Hubble flow. The quantity, quality, breadth of galactic environments, and homogeneous nature of the SNfactory dataset will make it the premier source of calibration for the Type Ia supernova width-brightness relation and the intrinsic supernova colors used for K-correction and correction for extinction by host-galaxy dust. This dataset will also allow an extensive investigation of additional parameters which possibly influence the quality of Type Ia supernovae as cosmological probes. The SNfactory search capabilities and follow-up instrumentation include wide-field CCD imagers on two 1.2-m telescopes (via collaboration with the Near Earth Asteroid Tracking team at JPL and the QUEST team at Yale), and a two-channel integral-field-unit optical spectrograph/imager being fabricated for the University of Hawaii 2.2-m telescope. In addition to ground-based follow-up, UV spectra for a subsample of these supernovae will be obtained with HST. The pipeline to obtain, transfer via wireless and standard internet, and automatically process the search images is in operation. Software and hardware development is now underway to enable the execution of follow-up spectroscopy of supernova candidates at the Hawaii 2.2-m telescope via automated remote control of the telescope and the IFU spectrograph/imager.

  4. The Physics of the B Factories

    NASA Astrophysics Data System (ADS)

    Bevan, A. J.; Golob, B.; Mannel, Th.; Prell, S.; Yabsley, B. D.; Aihara, H.; Anulli, F.; Arnaud, N.; Aushev, T.; Beneke, M.; Beringer, J.; Bianchi, F.; Bigi, I. I.; Bona, M.; Brambilla, N.; Brodzicka, J.; Chang, P.; Charles, M. J.; Cheng, C. H.; Cheng, H.-Y.; Chistov, R.; Colangelo, P.; Coleman, J. P.; Drutskoy, A.; Druzhinin, V. P.; Eidelman, S.; Eigen, G.; Eisner, A. M.; Faccini, R.; Flood, K. T.; Gambino, P.; Gaz, A.; Gradl, W.; Hayashii, H.; Higuchi, T.; Hulsbergen, W. D.; Hurth, T.; Iijima, T.; Itoh, R.; Jackson, P. D.; Kass, R.; Kolomensky, Yu. G.; Kou, E.; Križan, P.; Kronfeld, A.; Kumano, S.; Kwon, Y. J.; Latham, T. E.; Leith, D. W. G. S.; Lüth, V.; Martinez-Vidal, F.; Meadows, B. T.; Mussa, R.; Nakao, M.; Nishida, S.; Ocariz, J.; Olsen, S. L.; Pakhlov, P.; Pakhlova, G.; Palano, A.; Pich, A.; Playfer, S.; Poluektov, A.; Porter, F. C.; Robertson, S. H.; Roney, J. M.; Roodman, A.; Sakai, Y.; Schwanda, C.; Schwartz, A. J.; Seidl, R.; Sekula, S. J.; Steinhauser, M.; Sumisawa, K.; Swanson, E. S.; Tackmann, F.; Trabelsi, K.; Uehara, S.; Uno, S.; van de Water, R.; Vasseur, G.; Verkerke, W.; Waldi, R.; Wang, M. Z.; Wilson, F. F.; Zupan, J.; Zupanc, A.; Adachi, I.; Albert, J.; Banerjee, Sw.; Bellis, M.; Ben-Haim, E.; Biassoni, P.; Cahn, R. N.; Cartaro, C.; Chauveau, J.; Chen, C.; Chiang, C. C.; Cowan, R.; Dalseno, J.; Davier, M.; Davies, C.; Dingfelder, J. C.; Echenard, B.; Epifanov, D.; Fulsom, B. G.; Gabareen, A. M.; Gary, J. W.; Godang, R.; Graham, M. T.; Hafner, A.; Hamilton, B.; Hartmann, T.; Hayasaka, K.; Hearty, C.; Iwasaki, Y.; Khodjamirian, A.; Kusaka, A.; Kuzmin, A.; Lafferty, G. D.; Lazzaro, A.; Li, J.; Lindemann, D.; Long, O.; Lusiani, A.; Marchiori, G.; Martinelli, M.; Miyabayashi, K.; Mizuk, R.; Mohanty, G. B.; Muller, D. R.; Nakazawa, H.; Ongmongkolkul, P.; Pacetti, S.; Palombo, F.; Pedlar, T. K.; Piilonen, L. E.; Pilloni, A.; Poireau, V.; Prothmann, K.; Pulliam, T.; Rama, M.; Ratcliff, B. N.; Roudeau, P.; Schrenk, S.; Schroeder, T.; Schubert, K. R.; Shen, C. P.; Shwartz, B.; Soffer, A.; Solodov, E. P.; Somov, A.; Starič, M.; Stracka, S.; Telnov, A. V.; Todyshev, K. Yu.; Tsuboyama, T.; Uglov, T.; Vinokurova, A.; Walsh, J. J.; Watanabe, Y.; Won, E.; Wormser, G.; Wright, D. H.; Ye, S.; Zhang, C. C.; Abachi, S.; Abashian, A.; Abe, K.; Abe, N.; Abe, R.; Abe, T.; Abrams, G. S.; Adam, I.; Adamczyk, K.; Adametz, A.; Adye, T.; Agarwal, A.; Ahmed, H.; Ahmed, M.; Ahmed, S.; Ahn, B. S.; Ahn, H. S.; Aitchison, I. J. R.; Akai, K.; Akar, S.; Akatsu, M.; Akemoto, M.; Akhmetshin, R.; Akre, R.; Alam, M. S.; Albert, J. N.; Aleksan, R.; Alexander, J. P.; Alimonti, G.; Allen, M. T.; Allison, J.; Allmendinger, T.; Alsmiller, J. R. G.; Altenburg, D.; Alwyn, K. E.; An, Q.; Anderson, J.; Andreassen, R.; Andreotti, D.; Andreotti, M.; Andress, J. C.; Angelini, C.; Anipko, D.; Anjomshoaa, A.; Anthony, P. L.; Antillon, E. A.; Antonioli, E.; Aoki, K.; Arguin, J. 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A.; Natkaniec, Z.; Nauenberg, U.; Nayak, M.; Neal, H.; Nedelkovska, E.; Negrini, M.; Neichi, K.; Nelson, D.; Nelson, S.; Neri, N.; Nesom, G.; Neubauer, S.; Newman-Coburn, D.; Ng, C.; Nguyen, X.; Nicholson, H.; Niebuhr, C.; Nief, J. Y.; Niiyama, M.; Nikolich, M. B.; Nisar, N. K.; Nishimura, K.; Nishio, Y.; Nitoh, O.; Nogowski, R.; Noguchi, S.; Nomura, T.; Nordby, M.; Nosochkov, Y.; Novokhatski, A.; Nozaki, S.; Nozaki, T.; Nugent, I. M.; O'Grady, C. P.; O'Neale, S. W.; O'Neill, F. G.; Oberhof, B.; Oddone, P. J.; Ofte, I.; Ogawa, A.; Ogawa, K.; Ogawa, S.; Ogawa, Y.; Ohkubo, R.; Ohmi, K.; Ohnishi, Y.; Ohno, F.; Ohshima, T.; Ohshima, Y.; Ohuchi, N.; Oide, K.; Oishi, N.; Okabe, T.; Okazaki, N.; Okazaki, T.; Okuno, S.; Olaiya, E. O.; Olivas, A.; Olley, P.; Olsen, J.; Ono, S.; Onorato, G.; Onuchin, A. P.; Onuki, Y.; Ooba, T.; Orimoto, T. J.; Oshima, T.; Osipenkov, I. L.; Ostrowicz, W.; Oswald, C.; Otto, S.; Oyang, J.; Oyanguren, A.; Ozaki, H.; Ozcan, V. E.; Paar, H. P.; Padoan, C.; Paick, K.; Palka, H.; Pan, B.; Pan, Y.; Panduro Vazquez, W.; Panetta, J.; Panova, A. I.; Panvini, R. S.; Panzenböck, E.; Paoloni, E.; Paolucci, P.; Pappagallo, M.; Paramesvaran, S.; Park, C. S.; Park, C. W.; Park, H.; Park, H. K.; Park, K. S.; Park, W.; Parry, R. J.; Parslow, N.; Passaggio, S.; Pastore, F. C.; Patel, P. M.; Patrignani, C.; Patteri, P.; Pavel, T.; Pavlovich, J.; Payne, D. J.; Peak, L. S.; Peimer, D. R.; Pelizaeus, M.; Pellegrini, R.; Pelliccioni, M.; Peng, C. C.; Peng, J. C.; Peng, K. C.; Peng, T.; Penichot, Y.; Pennazzi, S.; Pennington, M. R.; Penny, R. C.; Penzkofer, A.; Perazzo, A.; Perez, A.; Perl, M.; Pernicka, M.; Perroud, J.-P.; Peruzzi, I. M.; Pestotnik, R.; Peters, K.; Peters, M.; Petersen, B. A.; Petersen, T. C.; Petigura, E.; Petrak, S.; Petrella, A.; Petrič, M.; Petzold, A.; Pia, M. G.; Piatenko, T.; Piccolo, D.; Piccolo, M.; Piemontese, L.; Piemontese, M.; Pierini, M.; Pierson, S.; Pioppi, M.; Piredda, G.; Pivk, M.; Plaszczynski, S.; Polci, F.; Pompili, A.; Poropat, P.; Posocco, M.; Potter, C. T.; Potter, R. J. L.; Prasad, V.; Prebys, E.; Prencipe, E.; Prendki, J.; Prepost, R.; Prest, M.; Prim, M.; Pripstein, M.; Prudent, X.; Pruvot, S.; Puccio, E. M. T.; Purohit, M. V.; Qi, N. D.; Quinn, H.; Raaf, J.; Rabberman, R.; Raffaelli, F.; Ragghianti, G.; Rahatlou, S.; Rahimi, A. M.; Rahmat, R.; Rakitin, A. Y.; Randle-Conde, A.; Rankin, P.; Rashevskaya, I.; Ratkovsky, S.; Raven, G.; Re, V.; Reep, M.; Regensburger, J. J.; Reidy, J.; Reif, R.; Reisert, B.; Renard, C.; Renga, F.; Ricciardi, S.; Richman, J. D.; Ritchie, J. L.; Ritter, M.; Rivetta, C.; Rizzo, G.; Roat, C.; Robbe, P.; Roberts, D. A.; Robertson, A. I.; Robutti, E.; Rodier, S.; Rodriguez, D. M.; Rodriguez, J. L.; Rodriguez, R.; Roe, N. A.; Röhrken, M.; Roethel, W.; Rolquin, J.; Romanov, L.; Romosan, A.; Ronan, M. T.; Rong, G.; Ronga, F. J.; Roos, L.; Root, N.; Rosen, M.; Rosenberg, E. I.; Rossi, A.; Rostomyan, A.; Rotondo, M.; Roussot, E.; Roy, J.; Rozanska, M.; Rozen, Y.; Rozen, Y.; Rubin, A. E.; Ruddick, W. O.; Ruland, A. M.; Rybicki, K.; Ryd, A.; Ryu, S.; Ryuko, J.; Sabik, S.; Sacco, R.; Saeed, M. A.; Safai Tehrani, F.; Sagawa, H.; Sahoo, H.; Sahu, S.; Saigo, M.; Saito, T.; Saitoh, S.; Sakai, K.; Sakamoto, H.; Sakaue, H.; Saleem, M.; Salnikov, A. A.; Salvati, E.; Salvatore, F.; Samuel, A.; Sanders, D. A.; Sanders, P.; Sandilya, S.; Sandrelli, F.; Sands, W.; Sands, W. R.; Sanpei, M.; Santel, D.; Santelj, L.; Santoro, V.; Santroni, A.; Sanuki, T.; Sarangi, T. R.; Saremi, S.; Sarti, A.; Sasaki, T.; Sasao, N.; Satapathy, M.; Sato, Nobuhiko; Sato, Noriaki; Sato, Y.; Satoyama, N.; Satpathy, A.; Savinov, V.; Savvas, N.; Saxton, O. H.; Sayeed, K.; Schaffner, S. F.; Schalk, T.; Schenk, S.; Schieck, J. R.; Schietinger, T.; Schilling, C. J.; Schindler, R. H.; Schmid, S.; Schmitz, R. E.; Schmuecker, H.; Schneider, O.; Schnell, G.; Schönmeier, P.; Schofield, K. C.; Schott, G.; Schröder, H.; Schram, M.; Schubert, J.; Schümann, J.; Schultz, J.; Schumm, B. A.; Schune, M. H.; Schwanke, U.; Schwarz, H.; Schwiening, J.; Schwierz, R.; Schwitters, R. F.; Sciacca, C.; Sciolla, G.; Scott, I. J.; Seeman, J.; Seiden, A.; Seitz, R.; Seki, T.; Sekiya, A. I.; Semenov, S.; Semmler, D.; Sen, S.; Senyo, K.; Seon, O.; Serbo, V. V.; Serednyakov, S. I.; Serfass, B.; Serra, M.; Serrano, J.; Settai, Y.; Seuster, R.; Sevior, M. E.; Shakhova, K. V.; Shang, L.; Shapkin, M.; Sharma, V.; Shebalin, V.; Shelkov, V. G.; Shen, B. C.; Shen, D. Z.; Shen, Y. T.; Sherwood, D. J.; Shibata, T.; Shibata, T. A.; Shibuya, H.; Shidara, T.; Shimada, K.; Shimoyama, M.; Shinomiya, S.; Shiu, J. G.; Shorthouse, H. W.; Shpilinskaya, L. I.; Sibidanov, A.; Sicard, E.; Sidorov, A.; Sidorov, V.; Siegle, V.; Sigamani, M.; Simani, M. C.; Simard, M.; Simi, G.; Simon, F.; Simonetto, F.; Sinev, N. B.; Singh, H.; Singh, J. B.; Sinha, R.; Sitt, S.; Skovpen, Yu. I.; Sloane, R. J.; Smerkol, P.; Smith, A. J. S.; Smith, D.; Smith, D. S.; Smith, J. G.; Smol, A.; Snoek, H. L.; Snyder, A.; So, R. Y.; Sobie, R. J.; Soderstrom, E.; Soha, A.; Sohn, Y. S.; Sokoloff, M. D.; Sokolov, A.; Solagna, P.; Solovieva, E.; Soni, N.; Sonnek, P.; Sordini, V.; Spaan, B.; Spanier, S. M.; Spencer, E.; Speziali, V.; Spitznagel, M.; Spradlin, P.; Staengle, H.; Stamen, R.; Stanek, M.; Stanič, S.; Stark, J.; Steder, M.; Steininger, H.; Steinke, M.; Stelzer, J.; Stevanato, E.; Stocchi, A.; Stock, R.; Stoeck, H.; Stoker, D. P.; Stroili, R.; Strom, D.; Strother, P.; Strube, J.; Stugu, B.; Stypula, J.; Su, D.; Suda, R.; Sugahara, R.; Sugi, A.; Sugimura, T.; Sugiyama, A.; Suitoh, S.; Sullivan, M. K.; Sumihama, M.; Sumiyoshi, T.; Summers, D. J.; Sun, L.; Sun, S.; Sundermann, J. E.; Sung, H. F.; Susaki, Y.; Sutcliffe, P.; Suzuki, A.; Suzuki, J.; Suzuki, J. I.; Suzuki, K.; Suzuki, S.; Suzuki, S. Y.; Swain, J. E.; Swain, S. K.; T'Jampens, S.; Tabata, M.; Tackmann, K.; Tajima, H.; Tajima, O.; Takahashi, K.; Takahashi, S.; Takahashi, T.; Takasaki, F.; Takayama, T.; Takita, M.; Tamai, K.; Tamponi, U.; Tamura, N.; Tan, N.; Tan, P.; Tanabe, K.; Tanabe, T.; Tanaka, H. A.; Tanaka, J.; Tanaka, M.; Tanaka, S.; Tanaka, Y.; Tanida, K.; Taniguchi, N.; Taras, P.; Tasneem, N.; Tatishvili, G.; Tatomi, T.; Tawada, M.; Taylor, F.; Taylor, G. N.; Taylor, G. P.; Telnov, V. I.; Teodorescu, L.; Ter-Antonyan, R.; Teramoto, Y.; Teytelman, D.; Thérin, G.; Thiebaux, Ch.; Thiessen, D.; Thomas, E. W.; Thompson, J. M.; Thorne, F.; Tian, X. C.; Tibbetts, M.; Tikhomirov, I.; Tinslay, J. S.; Tiozzo, G.; Tisserand, V.; Tocut, V.; Toki, W. H.; Tomassini, E. W.; Tomoto, M.; Tomura, T.; Torassa, E.; Torrence, E.; Tosi, S.; Touramanis, C.; Toussaint, J. C.; Tovey, S. N.; Trapani, P. P.; Treadwell, E.; Triggiani, G.; Trincaz-Duvoid, S.; Trischuk, W.; Troost, D.; Trunov, A.; Tsai, K. L.; Tsai, Y. T.; Tsujita, Y.; Tsukada, K.; Tsukamoto, T.; Tuggle, J. M.; Tumanov, A.; Tung, Y. W.; Turnbull, L.; Turner, J.; Turri, M.; Uchida, K.; Uchida, M.; Uchida, Y.; Ueki, M.; Ueno, K.; Ujiie, N.; Ulmer, K. A.; Unno, Y.; Urquijo, P.; Ushiroda, Y.; Usov, Y.; Usseglio, M.; Usuki, Y.; Uwer, U.; Va'vra, J.; Vahsen, S. E.; Vaitsas, G.; Valassi, A.; Vallazza, E.; Vallereau, A.; Vanhoefer, P.; van Hoek, W. C.; Van Hulse, C.; van Winkle, D.; Varner, G.; Varnes, E. W.; Varvell, K. E.; Vasileiadis, G.; Velikzhanin, Y. S.; Verderi, M.; Versillé, S.; Vervink, K.; Viaud, B.; Vidal, P. B.; Villa, S.; Villanueva-Perez, P.; Vinograd, E. L.; Vitale, L.; Vitug, G. M.; Voß, C.; Voci, C.; Voena, C.; Volk, A.; von Wimmersperg-Toeller, J. H.; Vorobyev, V.; Vossen, A.; Vuagnin, G.; Vuosalo, C. O.; Wacker, K.; Wagner, A. P.; Wagner, D. L.; Wagner, G.; Wagner, M. N.; Wagner, S. R.; Wagoner, D. E.; Walker, D.; Walkowiak, W.; Wallom, D.; Wang, C. C.; Wang, C. H.; Wang, J.; Wang, J. G.; Wang, K.; Wang, L.; Wang, L. L.; Wang, P.; Wang, T. J.; Wang, W. F.; Wang, X. L.; Wang, Y. F.; Wappler, F. R.; Watanabe, M.; Watson, A. T.; Watson, J. E.; Watson, N. K.; Watt, M.; Weatherall, J. H.; Weaver, M.; Weber, T.; Wedd, R.; Wei, J. T.; Weidemann, A. W.; Weinstein, A. J. R.; Wenzel, W. A.; West, C. A.; West, C. G.; West, T. J.; White, E.; White, R. M.; Wicht, J.; Widhalm, L.; Wiechczynski, J.; Wienands, U.; Wilden, L.; Wilder, M.; Williams, D. C.; Williams, G.; Williams, J. C.; Williams, K. M.; Williams, M. I.; Willocq, S. Y.; Wilson, J. R.; Wilson, M. G.; Wilson, R. J.; Winklmeier, F.; Winstrom, L. O.; Winter, M. A.; Wisniewski, W. J.; Wittgen, M.; Wittlin, J.; Wittmer, W.; Wixted, R.; Woch, A.; Wogsland, B. J.; Won, E.; Wong, Q. K.; Wray, B. C.; Wren, A. C.; Wright, D. M.; Wu, C. H.; Wu, J.; Wu, S. L.; Wulsin, H. W.; Xella, S. M.; Xie, Q. L.; Xie, Y.; Xu, Z. Z.; Yéche, Ch.; Yamada, Y.; Yamaga, M.; Yamaguchi, A.; Yamaguchi, H.; Yamaki, T.; Yamamoto, H.; Yamamoto, N.; Yamamoto, R. K.; Yamamoto, S.; Yamanaka, T.; Yamaoka, H.; Yamaoka, J.; Yamaoka, Y.; Yamashita, Y.; Yamauchi, M.; Yan, D. S.; Yan, Y.; Yanai, H.; Yanaka, S.; Yang, H.; Yang, R.; Yang, S.; Yarritu, A. K.; Yashchenko, S.; Yashima, J.; Yasin, Z.; Yasu, Y.; Ye, S. W.; Yeh, P.; Yi, J. I.; Yi, K.; Yi, M.; Yin, Z. W.; Ying, J.; Yocky, G.; Yokoyama, K.; Yokoyama, M.; Yokoyama, T.; Yoshida, K.; Yoshida, M.; Yoshimura, Y.; Young, C. C.; Yu, C. X.; Yu, Z.; Yuan, C. Z.; Yuan, Y.; Yumiceva, F. X.; Yusa, Y.; Yushkov, A. N.; Yuta, H.; Zacek, V.; Zain, S. B.; Zallo, A.; Zambito, S.; Zander, D.; Zang, S. L.; Zanin, D.; Zaslavsky, B. G.; Zeng, Q. L.; Zghiche, A.; Zhang, B.; Zhang, J.; Zhang, J.; Zhang, L.; Zhang, L. M.; Zhang, S. Q.; Zhang, Z. P.; Zhao, H. W.; Zhao, M.; Zhao, Z. G.; Zheng, Y.; Zheng, Y. H.; Zheng, Z. P.; Zhilich, V.; Zhou, P.; Zhu, R. Y.; Zhu, Y. S.; Zhu, Z. M.; Zhulanov, V.; Ziegler, T.; Ziegler, V.; Zioulas, G.; Zisman, M.; Zito, M.; Zürcher, D.; Zwahlen, N.; Zyukova, O.; Živko, T.; Žontar, D.

    2014-11-01

    This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C. Please note that version 3 on the archive is the auxiliary version of the Physics of the B Factories book. This uses the notation alpha, beta, gamma for the angles of the Unitarity Triangle. The nominal version uses the notation phi_1, phi_2 and phi_3. Please cite this work as Eur. Phys. J. C74 (2014) 3026.

  5. A Methodology for the Assessment of Experiential Learning Lean: The Lean Experience Factory Study

    ERIC Educational Resources Information Center

    De Zan, Giovanni; De Toni, Alberto Felice; Fornasier, Andrea; Battistella, Cinzia

    2015-01-01

    Purpose: The purpose of this paper is to present a methodology to assess the experiential learning processes of learning lean in an innovative learning environment: the lean model factories. Design/methodology/approach: A literature review on learning and lean management literatures was carried out to design the methodology. Then, a case study…

  6. Multilevel Factorial Experiments for Developing Behavioral Interventions: Power, Sample Size, and Resource Considerations

    ERIC Educational Resources Information Center

    Dziak, John J.; Nahum-Shani, Inbal; Collins, Linda M.

    2012-01-01

    Factorial experimental designs have many potential advantages for behavioral scientists. For example, such designs may be useful in building more potent interventions by helping investigators to screen several candidate intervention components simultaneously and to decide which are likely to offer greater benefit before evaluating the intervention…

  7. From super beams to neutrino factories

    SciTech Connect

    Bross, Alan; /Fermilab

    2009-11-01

    The Neutrino Factory, which produces an extremely intense source of flavor-tagged neutrinos from muon decays in a storage ring, arguably gives the best physics reach for CP violation, as well as virtually all parameters in the neutrino oscillation parameter space. I will briefly describe the physics capabilities of the baseline Neutrino Factory as compared to other possible future facilities ({beta}-beam and super-beam facilities), give an overview of the accelerator complex and describe in detail the current international R&D program.

  8. Radiative Penguin Decays at the B Factories

    SciTech Connect

    Koneke, Karsten; /MIT, LNS

    2007-11-16

    In this article, I review the most recent results in radiative penguin decays from the B factories Belle and BABAR. Most notably, I will talk about the recent new observations in the decays B {yields} ({rho}/{omega}) {gamma}, a new analysis technique in b {yields} s{gamma}, and first measurements of radiative penguin decays in the B{sup 0}{sub s} meson system. Finally, I will summarize the current status and future prospects of radiative penguin B physics at the B factories.

  9. SIMULATIONS OF A MUON LINAC FOR A NEUTRINO FACTORY

    SciTech Connect

    Kevin Beard, Alex Bogacz ,Slawomir Bogacz, Vasiliy Morozov, Yves Roblin

    2011-04-01

    The Neutrino Factory baseline design involves a complex chain of accelerators including a single-pass linac, two recirculating linacs and an FFAG. The first linac follows the capture and bunching section and accelerates the muons from about 244 to 900 MeV. It must accept a high emittance beam about 30 cm wide with a 10% energy spread. This linac uses counterwound, shielded superconducting solenoids and 201 MHz superconducting cavities. Simulations have been carried out using several codes including Zgoubi, OptiM, GPT, Elegant and G4beamline, both to determine the optics and to estimate the radiation loads on the elements due to beam loss and muon decay.

  10. THE ROLE OF QUANTUM MECHANICS IN NEUTRINO FACTORIES.

    SciTech Connect

    GALLARDO,J.C.; SESSLER,A.M.; WURTELE,J.

    2000-12-06

    A compilation is made of the various ways in which quantum phenomena enter into the design and operation of a neutrino factory. They include production of pions, decay of pions into muons, ionization energy loss of muons in material, scattering and energy straggling of muons in material, polarization of muons, and the decay of muons into neutrinos, and the radiation effect of neutrinos. For each process formulas are presented which cover the basic mechanism. A discussion is presented of the areas of uncertainty and of the experiments, underway and proposed, which will reduce the uncertainty to an acceptable level.

  11. MUON EDM EXPERIMENT USING STAGE II OF THE NEUTRINO FACTORY.

    SciTech Connect

    FERNOW,R.C.; GALLARDO,J.C.; MORSE,W.M.; SEMERTZIDIS,Y.K.

    2002-07-01

    During the second stage of a future neutrino factory unprecedented numbers of bunched muons will become available. The cooled medium-energy muon beam could be used for a high sensitivity search for an electric dipole moment (EDM) of the muon with a sensitivity better than 10{sup -24}e {center_dot} cm. This will make the sensitivity of the EDM experiment to non-standard physics competitive and in many models more sensitive than the present limits on edms of the electron and nucleons. The experimental design exploits the strong motional electric field sensed by relativistic particles in a magnetic storage ring.

  12. The International Muon Ionization Cooling Experiment: MICE and Neutrino Factories

    NASA Astrophysics Data System (ADS)

    Freemire, Ben

    2010-03-01

    The Muon Ionization Cooling Experiment (MICE) is an accelerator and particle physics experiment aimed at demonstrating the technique of ionization cooling on a beam of muons. Ionization cooling is the process by which muons are sent through an absorbing material, thereby losing energy and decreasing their normalized emittance. The muons are then reaccelerated in the appropriate direction with radio frequency (RF) cavities. This produces an overall reduction in transverse emittance of the muon beam. Ionization cooling could be a key technique in the design of a high intensity Neutrino Factory.

  13. Interaction Region Upgrades of e+ e- B-Factories

    SciTech Connect

    Sullivan, M.; /SLAC

    2008-02-22

    Both the PEP-II and KEKB B-Factories have plans to upgrade their Interaction Regions (IRs) in order to improve luminosity performance. Last summer PEP-II added cooling to the IR beam pipe in order to increase beam currents thereby raising the luminosity. In addition, PEP-II is working on a design that modifies the permanent magnets near the Interaction Point (IP) for an even higher luminosity increase. KEKB is also planning an improvement to their IR that will decrease the detector beam pipe radius. In addition, KEK has a design to increase the luminosity of KEKB to 1 x 10{sup 35} cm{sup -2} sec{sup -1} which includes changes to the IR. PEP-II is also investigating the feasibility of a 1 x 10{sup 36} cm{sup -2} sec{sup -1} luminosity design. I summarize these various upgrades and concentrate on issues common to the different designs.

  14. Uniqueness of Three-Mode Factor Models with Sparse Cores: The 3 x 3 x 3 Case.

    ERIC Educational Resources Information Center

    Kiers, Henk A. L.; Ten Berge, Jos M. F.; Rocci, Roberto

    1997-01-01

    Three-mode factor analysis (3MFA) and PARAFAC are methods that describe three-way data. A class of 3MFA models is introduced that falls between 3MFA and PARAFAC and contains the good properties of both approaches, including the unique axes property that has distinguished the PARAFAC model. (SLD)

  15. Simulating A Factory Via Software

    NASA Technical Reports Server (NTRS)

    Schroer, Bernard J.; Zhang, Shou X.; Tseng, Fan T.

    1990-01-01

    Software system generates simulation program from user's responses to questions. AMPS/PC system is simulation software tool designed to aid user in defining specifications of manufacturing environment and then automatically writing code for target simulation language, GPSS/PC. Domain of problems AMPS/PC simulates is that of manufacturing assembly lines with subassembly lines and manufacturing cells. Written in Turbo Pascal Version 4.

  16. Semileptonic B Decays at the B Factories

    SciTech Connect

    Bozzi, Concezio; /INFN, Ferrara

    2006-09-25

    Recent results on inclusive and exclusive semileptonic B decays from B Factories are presented. The status and perspectives of the determination of the CKM matrix elements V{sub ub} and V{sub cb} with semileptonic B decays is discussed.

  17. Performance Comparison: Superbeams, Beta Beams, Neutrino Factory

    SciTech Connect

    Winter, Walter

    2011-10-06

    In this talk, the performance comparison among superbeams (SB), beta beams (BB), and the Neutrino Factory (NF) is discussed. The ingredients to such a comparison are described, and the optimization and status of BB and NF are addressed. Finally, one example for the performance comparison is shown.

  18. Making Connections: After the Factories Revisited.

    ERIC Educational Resources Information Center

    Rosenfeld, Stuart A.; Bergman, Edward M.

    This analysis of employment patterns in the American South extends a 1985 report, "After the Factories: Changing Employment Patterns in the Rural South," which was based on the years between 1977-1982. The 1985 report included Texas, but this analysis includes only the 12 Southern Growth Policies Board (SGPB) member states. This new analysis…

  19. Comments on a linac based beauty factory

    SciTech Connect

    Samuel Heifets; Geoffrey Krafft; C. McDowell; M. Fripp

    1990-02-01

    A consistent set of parameters is given for a B-factory based on collisions of an electron beam from a SRF linac with the positron beam in a storage ring. An optimized lattice, an impedance estimate, a study of beam stability, and a discussion of collisions with large disruption parameters are included.

  20. Speech Differences of Factory Worker Age Groups.

    ERIC Educational Resources Information Center

    Tway, Patricia

    1975-01-01

    This article, which focuses on speech differences of age groups, is part of a larger study of occupational jargon, its characteristics and underlying features and the part it plays in reflecting the workers' knowledge of their jobs and their attitudes toward jobs in general. The project incorporated a case method of research in a china factory.…

  1. An Epiphany in a Toilet Factory

    ERIC Educational Resources Information Center

    Cobb, Catlin

    2009-01-01

    In this article, the author shares her experiences of the universality of art making and artistic experience of being a dancer and teaching artist. She describes her performance at Kohler, a worldwide leader in plumbing products in Spartanburg, South Carolina, where she had an epiphany dancing in a toilet factory--a sudden, intuitive moment of…

  2. The Factory of the Future

    NASA Technical Reports Server (NTRS)

    Byman, J. E.

    1985-01-01

    A brief history of aircraft production techniques is given. A flexible machining cell is then described. It is a computer controlled system capable of performing 4-axis machining part cleaning, dimensional inspection and materials handling functions in an unmanned environment. The cell was designed to: allow processing of similar and dissimilar parts in random order without disrupting production; allow serial (one-shipset-at-a-time) manufacturing; reduce work-in-process inventory; maximize machine utilization through remote set-up; maximize throughput and minimize labor.

  3. Tu-144LL Factory scenes

    NASA Technical Reports Server (NTRS)

    1995-01-01

    A jointly funded activity by the NASA High Speed Research (HSR) program and the Boeing Commercial Airplane Group took place to obtain experimental flight data on the Tu-144 supersonic transport built by Russia. The Tu-144 was modified by the Tupolev Aircraft Design Bureau, Moscow, Russia, in 1995-1996 into the Tu-144LL Flying Laboratory to perform flight experiments as part of the NASA HSR Program. Knowledge gained from the flights will benefit the NASA efforts to develop the technology that may enable design of an efficient, environmentally friendly second-generation supersonic transport in this country. This program involved eight experiments -- six aboard the aircraft and two ground test engine experiments. Between November 1996 and February 1998 the Tu-144LL flew 19 research flights. The follow-on Tu-144LL program encompassed about eight flights, focusing on extensions of five experiments from the first project and two new experiments to measure fuel system temperatures and to define in-flight wing deflections. This movie clip runs 1:17 minutes and shows several different views of the Russian Tu-144 LL supersonic transport, on the ramp, in its hangar, a rear view of the engine exhaust nozzles, the avionics bay, cockpit and finally a shot looking forward along the fuselage from the tail.

  4. Investigation of Beam Loading Effects for the Neutrino Factory Muon Accelerator

    SciTech Connect

    J. Pozimski,M. Aslaninejad,C. Bontoiu,S. Berg,Alex Bogacz

    2010-05-01

    The International design study (IDS) study showed that a Neutrino Factory [1] seems to be the most promising candidate for the next phase of high precision neutrino oscillation experiments. One part of the increased precision is due to the fact that in a Neutrino Factory the decay of muons produces a neutrino beam with narrow energy distribution and divergence. The effect of beam loading on the energy distribution of the muon beam in the Neutrino Factory decay rings has been investigated numerically. The simulations have been performed using the baseline accelerator design including cavities for different number of bunch trains and bunch train timing. A detailed analysis of the beam energy distribution expected is given together with a discussion of the energy spread produced by the gutter acceleration in the FFAG and the implications for the neutrino oscillation experiments will be presented.

  5. Muon Bunching and Phase-Energy Rotation for a Neutrino Factory and Muon Collider

    NASA Astrophysics Data System (ADS)

    Neuffer, David; Yoshikawa, Cary

    2008-04-01

    We have developed scenarios for capture, bunching and phase-energy rotation of muons from a proton source, using high-frequency rf systems. The method captures a maximal number of muons into a string of rf bunches with initial application in the neutrino factory design studies. For a muon collider, these bunches must be recombined for maximal luminosity, and our initial design produced a relatively long bunch train. In this paper we present more compact scenarios that obtain a smaller number of bunches, and, after some optimization, obtain cases that are better for both neutrino-factory and collider scenarios. We also consider further modification by incorporating hydrogen gas-filled rf cavities for bunching and cooling. We describe these examples and consider variations toward an optimal factory + collider scenario.

  6. Comments on particle identification at the B factory

    SciTech Connect

    Ratcliff, B.N.

    1992-07-01

    The importance of particle identification at an asymmetric B factory is discussed and the general status of a number of particle identification technologies which might be included in B factory detectors is briefly reviewed.

  7. 4. OVERALL VIEW OF FACTORY COMPLEX, WITH DIGESTER HOUSE IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. OVERALL VIEW OF FACTORY COMPLEX, WITH DIGESTER HOUSE IN LEFT FOREGROUND. VIEW TO NORTHWEST. - Commercial & Industrial Buildings, Maizewood Insulation Company Factory, 275 Salina Street, Dubuque, Dubuque County, IA

  8. 2. OVERALL VIEW OF FACTORY COMPLEX, WITH BOILER HOUSE IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. OVERALL VIEW OF FACTORY COMPLEX, WITH BOILER HOUSE IN CENTER GROUND. VIEW TO NORTH. - Commercial & Industrial Buildings, Maizewood Insulation Company Factory, 275 Salina Street, Dubuque, Dubuque County, IA

  9. 5. OVERALL VIEW OF FACTORY COMPLEX, WITH DIGESTER HOUSE IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. OVERALL VIEW OF FACTORY COMPLEX, WITH DIGESTER HOUSE IN LEFT FOREGROUND. VIEW TO NORTHWEST. - Commercial & Industrial Buildings, Maizewood Insulation Company Factory, 275 Salina Street, Dubuque, Dubuque County, IA

  10. 5. SOUTH SIDE AND EAST FRONT OF FACTORY, WITH POWER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. SOUTH SIDE AND EAST FRONT OF FACTORY, WITH POWER HOUSE IN FOREGROUND. VIEW TO NORTHWEST. - Commercial & Industrial Buildings, James Beach & Sons Company Factory & Warehouse, 57 South Locust Street, Dubuque, Dubuque County, IA

  11. 31. THE BRICK BUILDING IS THE FACTORY BEFORE LATER ADDITIONS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. THE BRICK BUILDING IS THE FACTORY BEFORE LATER ADDITIONS, LOOKING NORTHWEST. TAKEN CIRCA 1886-90, PHOTOGRAPHER UNKNOWN. - Ybor Cigar Factory, 1916 North Fourteenth Street, Tampa, Hillsborough County, FL

  12. 1. EAST AND NORTH FACADES OF NABISCO CARTON FACTORY, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND NORTH FACADES OF NABISCO CARTON FACTORY, LOOKING SOUTHWEST ALONG MARSEILLES POWER CANAL - National Biscuit Company, Marseilles Factory, Off Main Street on Marseilles Power Canal, Marseilles, La Salle County, IL

  13. Production of Tetraquark State Tcc at B-Factories

    NASA Astrophysics Data System (ADS)

    Reyima, Rashidin

    2013-12-01

    We study production of the tetraquark state Tcc via virtual photon at the B-factories in the QCD factorization framework. We predict the cross section of tetraquark state production in the leading order at the B-factories.

  14. Silanization of glass chips—A factorial approach for optimization

    NASA Astrophysics Data System (ADS)

    Vistas, Cláudia R.; Águas, Ana C. P.; Ferreira, Guilherme N. M.

    2013-12-01

    Silanization of glass chips with 3-mercaptopropyltrimethoxysilane (MPTS) was investigated and optimized to generate a high-quality layer with well-oriented thiol groups. A full factorial design was used to evaluate the influence of silane concentration and reaction time. The stabilization of the silane monolayer by thermal curing was also investigated, and a disulfide reduction step was included to fully regenerate the thiol-modified surface function. Fluorescence analysis and water contact angle measurements were used to quantitatively assess the chemical modifications, wettability and quality of modified chip surfaces throughout the silanization, curing and reduction steps. The factorial design enables a systematic approach for the optimization of glass chips silanization process. The optimal conditions for the silanization were incubation of the chips in a 2.5% MPTS solution for 2 h, followed by a curing process at 110 °C for 2 h and a reduction step with 10 mM dithiothreitol for 30 min at 37 °C. For these conditions the surface density of functional thiol groups was 4.9 × 1013 molecules/cm2, which is similar to the expected maximum coverage obtained from the theoretical estimations based on projected molecular area (∼5 × 1013 molecules/cm2).

  15. The U.S. Effort in Neutrino Factories

    SciTech Connect

    R. Raja

    2001-08-16

    We discuss the physics case for a neutrino factory and present the status of the effort in the U.S in making the neutrino factory a reality. We present the results from the two feasibility studies done on the factory and describe the R&D activities in collecting, cooling and accelerating muons. A staged scenario in which a neutrino factory is realized step by step is presented.

  16. 46 CFR 162.050-13 - Factory production and inspection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 6 2011-10-01 2011-10-01 false Factory production and inspection. 162.050-13 Section....050-13 Factory production and inspection. (a) Equipment manufactured under Coast Guard approval must... any time to visit a factory where the equipment is manufactured to conduct an inspection of...

  17. 27 CFR 45.33 - Return of shipment to factory.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... factory. 45.33 Section 45.33 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... factory. Tobacco products, and cigarette papers and tubes which have been removed, under this part, may be returned to the factory without internal revenue supervision. (72 Stat. 1418, as amended; 26 U.S.C. 5704)...

  18. 27 CFR 45.33 - Return of shipment to factory.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... factory. 45.33 Section 45.33 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... factory. Tobacco products, and cigarette papers and tubes which have been removed, under this part, may be returned to the factory without internal revenue supervision. (72 Stat. 1418, as amended; 26 U.S.C. 5704)...

  19. 46 CFR 164.009-23 - Factory inspection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Factory inspection. 164.009-23 Section 164.009-23...: SPECIFICATIONS AND APPROVAL MATERIALS Noncombustible Materials for Merchant Vessels § 164.009-23 Factory... regular schedule. However, the Commander of the Coast Guard District in which a factory is located...

  20. 46 CFR 162.050-13 - Factory production and inspection.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 6 2012-10-01 2012-10-01 false Factory production and inspection. 162.050-13 Section....050-13 Factory production and inspection. (a) Equipment manufactured under Coast Guard approval must... any time to visit a factory where the equipment is manufactured to conduct an inspection of...

  1. 27 CFR 45.33 - Return of shipment to factory.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... factory. 45.33 Section 45.33 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... factory. Tobacco products, and cigarette papers and tubes which have been removed, under this part, may be returned to the factory without internal revenue supervision. (72 Stat. 1418, as amended; 26 U.S.C. 5704)...

  2. 27 CFR 40.47 - Other businesses within factory.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... factory. 40.47 Section 40.47 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... AND TUBES, AND PROCESSED TOBACCO Administrative Provisions § 40.47 Other businesses within factory. (a) General. The appropriate TTB officer may authorize such other businesses within the factory of...

  3. 27 CFR 40.47 - Other businesses within factory.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... factory. 40.47 Section 40.47 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... AND TUBES, AND PROCESSED TOBACCO Administrative Provisions § 40.47 Other businesses within factory. (a) General. The appropriate TTB officer may authorize such other businesses within the factory of...

  4. 27 CFR 40.72 - Use of factory premises.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Use of factory premises... factory premises. (a) General. Unless otherwise authorized by the appropriate TTB officer as provided in § 40.47, the premises used by a manufacturer of tobacco products for his factory shall be...

  5. 27 CFR 40.47 - Other businesses within factory.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... factory. 40.47 Section 40.47 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... AND TUBES, AND PROCESSED TOBACCO Administrative Provisions § 40.47 Other businesses within factory. (a) General. The appropriate TTB officer may authorize such other businesses within the factory of...

  6. 27 CFR 40.72 - Use of factory premises.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Use of factory premises... factory premises. (a) General. Unless otherwise authorized by the appropriate TTB officer as provided in § 40.47, the premises used by a manufacturer of tobacco products for his factory shall be...

  7. 27 CFR 45.33 - Return of shipment to factory.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... factory. 45.33 Section 45.33 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... factory. Tobacco products, and cigarette papers and tubes which have been removed, under this part, may be returned to the factory without internal revenue supervision. (72 Stat. 1418, as amended; 26 U.S.C. 5704)...

  8. 46 CFR 164.009-23 - Factory inspection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 6 2011-10-01 2011-10-01 false Factory inspection. 164.009-23 Section 164.009-23...: SPECIFICATIONS AND APPROVAL MATERIALS Noncombustible Materials for Merchant Vessels § 164.009-23 Factory... regular schedule. However, the Commander of the Coast Guard District in which a factory is located...

  9. 46 CFR 164.009-23 - Factory inspection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 6 2013-10-01 2013-10-01 false Factory inspection. 164.009-23 Section 164.009-23...: SPECIFICATIONS AND APPROVAL MATERIALS Noncombustible Materials for Merchant Vessels § 164.009-23 Factory... regular schedule. However, the Commander of the Coast Guard District in which a factory is located...

  10. 27 CFR 40.72 - Use of factory premises.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Use of factory premises... factory premises. (a) General. Unless otherwise authorized by the appropriate TTB officer as provided in § 40.47, the premises used by a manufacturer of tobacco products for his factory shall be...

  11. 46 CFR 164.009-23 - Factory inspection.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 6 2012-10-01 2012-10-01 false Factory inspection. 164.009-23 Section 164.009-23...: SPECIFICATIONS AND APPROVAL MATERIALS Noncombustible Materials for Merchant Vessels § 164.009-23 Factory... regular schedule. However, the Commander of the Coast Guard District in which a factory is located...

  12. 27 CFR 40.72 - Use of factory premises.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Use of factory premises... factory premises. (a) General. Unless otherwise authorized by the appropriate TTB officer as provided in § 40.47, the premises used by a manufacturer of tobacco products for his factory shall be...

  13. 27 CFR 40.72 - Use of factory premises.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Use of factory premises. 40... factory premises. (a) General. Unless otherwise authorized by the appropriate TTB officer as provided in § 40.47, the premises used by a manufacturer of tobacco products for his factory shall be...

  14. 27 CFR 45.33 - Return of shipment to factory.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... factory. 45.33 Section 45.33 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... factory. Tobacco products, and cigarette papers and tubes which have been removed, under this part, may be returned to the factory without internal revenue supervision. (72 Stat. 1418, as amended; 26 U.S.C. 5704)...

  15. 46 CFR 164.009-23 - Factory inspection.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 6 2014-10-01 2014-10-01 false Factory inspection. 164.009-23 Section 164.009-23...: SPECIFICATIONS AND APPROVAL MATERIALS Noncombustible Materials for Merchant Vessels § 164.009-23 Factory... regular schedule. However, the Commander of the Coast Guard District in which a factory is located...

  16. 46 CFR 162.050-13 - Factory production and inspection.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 6 2014-10-01 2014-10-01 false Factory production and inspection. 162.050-13 Section....050-13 Factory production and inspection. (a) Equipment manufactured under Coast Guard approval must... any time to visit a factory where the equipment is manufactured to conduct an inspection of...

  17. 46 CFR 162.050-13 - Factory production and inspection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 6 2013-10-01 2013-10-01 false Factory production and inspection. 162.050-13 Section....050-13 Factory production and inspection. (a) Equipment manufactured under Coast Guard approval must... any time to visit a factory where the equipment is manufactured to conduct an inspection of...

  18. Testing Factorial Invariance in Multilevel Data: A Monte Carlo Study

    ERIC Educational Resources Information Center

    Kim, Eun Sook; Kwok, Oi-man; Yoon, Myeongsun

    2012-01-01

    Testing factorial invariance has recently gained more attention in different social science disciplines. Nevertheless, when examining factorial invariance, it is generally assumed that the observations are independent of each other, which might not be always true. In this study, we examined the impact of testing factorial invariance in multilevel…

  19. The Virtual Factory Teaching System (VFTS): Project Review and Results.

    ERIC Educational Resources Information Center

    Kazlauskas, E. J.; Boyd, E. F., III; Dessouky, M. M.

    This paper presents a review of the Virtual Factory Teaching (VFTS) project, a Web-based, multimedia collaborative learning network. The system allows students, working alone or in teams, to build factories, forecast demand for products, plan production, establish release rules for new work into the factory, and set scheduling rules for…

  20. 3. SOUTH AND WEST ELEVATION OF IPA FACTORY; TWOSTORY SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. SOUTH AND WEST ELEVATION OF IPA FACTORY; TWO-STORY SECTION WITH BRICK PARAPET BUILT WITH FACTORY EXPANSION CA. 1948. GABLE ROOF SECTION IS PART OF ORIGINAL 1892 FACTORY. TO THE RIGHT IS AN ABANDONED (COMMONWEALTH EDISON) ELECTRICAL SUBSTATION. - Illinois Pure Aluminum Company, 109 Holmes Street, Lemont, Cook County, IL

  1. 2. LOOKING NORTH ON COMMERCE ST. SHOWING HARMON MATTRESS FACTORY. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. LOOKING NORTH ON COMMERCE ST. SHOWING HARMON MATTRESS FACTORY. BRIDGE CONNECTS HARMON MATTRESS FACTORY WITH HARMON WAREHOUSE (SEE PHOTO HABS WA-165-15). BUILDING IN LEFT FOREGROUND IS LINDSTROM-BERG CABINET FACTORY (SEE PHOTO HABS WA-165-36). - Union Depot Area Study, F. S. Harmon Mattress Company, 1953 South C Street, Tacoma, Pierce County, WA

  2. Occupational dermatitis in a prefabrication construction factory.

    PubMed

    Goh, C L; Gan, S L; Ngui, S J

    1986-10-01

    In a field study of occupational dermatoses in a prefabrication construction factory, 272 workers were interviewed, examined and patch tested to chromate, cobalt, nickel, rubber mixes, epoxy resin, melamine formaldehyde and conplasts. The prevalence of occupational dermatitis was 14% (38/272); 57% (22/38) were irritant dermatitis from cement; 39.5% (15/38) were allergic contact dermatitis from cement (2 with concomitant rubber glove allergy); and 2.5% (1/38) were allergic to rubber chemicals in gloves. The overall prevalence of chromate sensitivity was 8.5% (23/272), with the highest rate from the concreting bays of the factory. The rate was unrelated to the duration of workers' engagement in construction work. 34.8% (8/23) had asymptomatic chromate allergy. The prevalence of cobalt reactions was 17.4% (4/23) and all were associated with chromate allergy. PMID:2948758

  3. B Physics at the B-Factories

    SciTech Connect

    Faccini, Riccardo

    2005-10-12

    After six years of data taking the B-Factories are now providing measurements with an accuracy which is beyond expectations. All the angles and sides of the unitarity triangle are measured to unprecedented accuracy and with several different techniques. This redundancy of measurements, in agreement with the Standard Model, allows to probe models for new physics. This paper summarizes the current results with particular emphasis on novel techniques.

  4. Byssinosis in ginning factories of rural Sindh.

    PubMed

    Aziz, S; Lodi, T Z; Alam, S E

    1992-10-01

    Frequency of byssinosis in 276 workers from 5 ginning factories of rural Sindh are described. Twenty-four (9%) had byssinosis, 178 were asymptomatic and the remaining 74 had other respiratory symptoms. Chronic obstructive pulmonary disease was present both in symptomatic and asymptomatic workers and was equally distributed amongst smokers and non-smokers. A possible involvement of some factors other than cigarette smoking is discussed. PMID:1469765

  5. New Physics Results from the B Factories

    SciTech Connect

    Sangro, Riccardo de

    2010-02-10

    We present a review of some recent experimental searches for new physics effects in precision flavour physics measurements performed at B factories. Recent results on selected leptonic, semi-leptonic and hadronic charm-less B decay channels studied by the BaBar and Belle collaborations will be presented and their implication within the framework of model extensions of the Standard Model will be discussed.

  6. Last Year of PEP-II B-Factory Operation

    SciTech Connect

    Seeman, J.; /SLAC

    2011-11-02

    The PEP-II B-Factory at SLAC (3.1 GeV e{sup +} x 9.0 GeV e{sup -}) operated from 1999 to 2008, delivering luminosity to the BaBar experiment. The design luminosity was reached after one and a half years of operation. In the end PEP-II surpassed by four times its design luminosity reaching 1.21 x 10{sup 34} cm{sup -2} s{sup -1}. It also set stored beam current records of 2.1 A e{sup -} and 3.2 A e{sup +}. Continuous injection was implemented with BaBar taking data. The total delivered luminosity to the BaBar detector was 557.4 fb{sup -1} spanning five upsilon resonances. PEP-II was constructed by SLAC, LBNL, and LLNL with help from BINP, IHEP, the BaBar collaboration, and the US DOE OHEP.

  7. Reducing backgrounds in the higgs factory muon collider detector

    SciTech Connect

    Mokhov, N. V.; Tropin, I. S.

    2014-06-01

    A preliminary design of the 125-GeV Higgs Factory (HF) Muon Collider (MC) has identified an enormous background loads on the HF detector. This is related to the twelve times higher muon decay probability at HF compared to that previously studied for the 1.5-TeV MC. As a result of MARS15 optimization studies, it is shown that with a carefully designed protection system in the interaction region, in the machine-detector interface and inside the detector one can reduce the background rates to a manageable level similar to that achieved for the optimized 1.5-TeV case. The main characteristics of the HF detector background are presented for the configuration found.

  8. WATER FACTORY 21: RECLAIMED WATER, VOLATILE ORGANICS, VIRUS, AND TREATMENT PERFORMANCE

    EPA Science Inventory

    This report describes the performance of Water Factory 21, a 0.66 cu m/s advanced wastewater treatment plant designed to reclaim secondary effluent from a municipal wastewater treatment plant so that it can be used for injection and recharge of a groundwater system. Included in t...

  9. Data scanner and event builder for the SMVD of the KEK B-factory

    NASA Astrophysics Data System (ADS)

    Tanka, Manobu; Ikeda, Hirokazu; Fujita, Youichi; Ozaki, Hitoshi; Fukunaga, Chikara

    1994-02-01

    We are designing a readout system for a silicon microstrip vertex detector (SMVD) to be used in the KEK B-factory experiment. In order to obtain optimum numbers for the buffer size and the processing time we have constructed a simplified model using Verilog hardware description language (HDL). We estimated the live-time fraction of the SMVD readout system for various configurations.

  10. The Lowell Mill Girls: Life in the Factory. Perspectives on History Series.

    ERIC Educational Resources Information Center

    Weisman, JoAnne B., Ed.

    This collection of essays and short stories is designed to provide a glimpse of life in the factory for the women who worked in the cotton mills of Lowell, Massachusetts in the 1840s. The book, which contains two primary sources (i.e., materials written by contemporaries), and three secondary sources, begins with a brief introduction to the…

  11. Brief Motivational and Parent Interventions for College Students: A Randomized Factorial Study

    ERIC Educational Resources Information Center

    Wood, Mark D.; Fairlie, Anne M.; Fernandez, Anne C.; Borsari, Brian; Capone, Christy; Laforge, Robert; Carmona-Barros, Rosa

    2010-01-01

    Objective: Using a randomized factorial design, we examined the efficacy of a brief motivational intervention (BMI) and a parent-based intervention (PBI) as universal preventive interventions to reduce alcohol use among incoming college students. Method: Participants (N = 1,014) were assessed prior to matriculation and at 10 months and 22 months…

  12. The 9-item Bergen Burnout Inventory: factorial validity across organizations and measurements of longitudinal data.

    PubMed

    Feldt, Taru; Rantanen, Johanna; Hyvönen, Katriina; Mäkikangas, Anne; Huhtala, Mari; Pihlajasaari, Pia; Kinnunen, Ulla

    2014-01-01

    The present study tested the factorial validity of the 9-item Bergen Burnout Inventory (BBI-9). The BBI-9 is comprised of three core dimensions: (1) exhaustion at work; (2) cynicism toward the meaning of work; and (3) sense of inadequacy at work. The study further investigated whether the three-factor structure of the BBI-9 remains the same across different organizations (group invariance) and measurement time points (time invariance). The factorial group invariance was tested using a cross-sectional design with data pertaining to managers (n=742), and employees working in a bank (n=162), an engineering office (n=236), a public sector organization divided into three service areas: administration (n=102), education and culture (n=581), and social affairs and health (n=1,505). Factorial time invariance was tested using longitudinal data pertaining to managers, with three measurements over a four-year follow-up period. The confirmatory factor analysis revealed that the three-factor structure of the BBI-9 was invariant across cross-sectional samples. The factorial invariance was also supported across measurement times. To conclude, the factorial structure of the BBI-9 was found to remain the same regardless of the sample properties and measurement times. PMID:24366535

  13. Neutrino factory in stages: Low energy, high energy, off-axis

    SciTech Connect

    Tang Jian; Winter, Walter

    2010-02-01

    We discuss neutrino oscillation physics with a neutrino factory in stages, including the possibility of upgrading the muon energy within the same program. We point out that a detector designed for the low energy neutrino factory may be used off axis in a high energy neutrino factory beam. We include the re-optimization of the experiment depending on the value of {theta}{sub 13} found. As upgrade options, we consider muon energy, additional baselines, a detector mass upgrade, an off-axis detector, and the platinum (muon to electron neutrino) channels. In addition, we test the impact of Daya Bay data on the optimization. We find that for large {theta}{sub 13} ({theta}{sub 13} discovered by the next generation of experiments), a low energy neutrino factory might be the most plausible minimal version to test the unknown parameters. However, if a higher muon energy is needed for new physics searches, a high energy version including an off-axis detector may be an interesting alternative. For small {theta}{sub 13} ({theta}{sub 13} not discovered by the next generation), a plausible program could start with a low energy neutrino factory, followed by energy upgrade, and then baseline or detector mass upgrade, depending on the outcome of the earlier phases.

  14. Industrial systems biology and its impact on synthetic biology of yeast cell factories.

    PubMed

    Fletcher, Eugene; Krivoruchko, Anastasia; Nielsen, Jens

    2016-06-01

    Engineering industrial cell factories to effectively yield a desired product while dealing with industrially relevant stresses is usually the most challenging step in the development of industrial production of chemicals using microbial fermentation processes. Using synthetic biology tools, microbial cell factories such as Saccharomyces cerevisiae can be engineered to express synthetic pathways for the production of fuels, biopharmaceuticals, fragrances, and food flavors. However, directing fluxes through these synthetic pathways towards the desired product can be demanding due to complex regulation or poor gene expression. Systems biology, which applies computational tools and mathematical modeling to understand complex biological networks, can be used to guide synthetic biology design. Here, we present our perspective on how systems biology can impact synthetic biology towards the goal of developing improved yeast cell factories. Biotechnol. Bioeng. 2016;113: 1164-1170. © 2015 Wiley Periodicals, Inc. PMID:26524089

  15. A Market-Based Approach to Multi-factory Scheduling

    NASA Astrophysics Data System (ADS)

    Vytelingum, Perukrishnen; Rogers, Alex; MacBeth, Douglas K.; Dutta, Partha; Stranjak, Armin; Jennings, Nicholas R.

    In this paper, we report on the design of a novel market-based approach for decentralised scheduling across multiple factories. Specifically, because of the limitations of scheduling in a centralised manner - which requires a center to have complete and perfect information for optimality and the truthful revelation of potentially commercially private preferences to that center - we advocate an informationally decentralised approach that is both agile and dynamic. In particular, this work adopts a market-based approach for decentralised scheduling by considering the different stakeholders representing different factories as self-interested, profit-motivated economic agents that trade resources for the scheduling of jobs. The overall schedule of these jobs is then an emergent behaviour of the strategic interaction of these trading agents bidding for resources in a market based on limited information and their own preferences. Using a simple (zero-intelligence) bidding strategy, we empirically demonstrate that our market-based approach achieves a lower bound efficiency of 84%. This represents a trade-off between a reasonable level of efficiency (compared to a centralised approach) and the desirable benefits of a decentralised solution.

  16. Methods for economic evaluation of a factorial-design cluster randomised controlled trial of a nutrition supplement and an exercise programme among healthy older people living in Santiago, Chile: the CENEX study

    PubMed Central

    Walker, Damian G; Aedo, Cristian; Albala, Cecilia; Allen, Elizabeth; Dangour, Alan D; Elbourne, Diana; Grundy, Emily; Uauy, Ricardo

    2009-01-01

    Background In an effort to promote healthy ageing and preserve health and function, the government of Chile has formulated a package of actions into the Programme for Complementary Food in Older People (Programa de Alimentación Complementaria para el Adulto Mayor - PACAM). The CENEX study was designed to evaluate the impact, cost and cost-effectiveness of the PACAM and a specially designed exercise programme on pneumonia incidence, walking capacity and body mass index in healthy older people living in low- to medium-socio-economic status areas of Santiago. The purpose of this paper is to describe in detail the methods that will be used to estimate the incremental costs and cost-effectiveness of the interventions. Methods and design The base-case analysis will adopt a societal perspective, including the direct medical and non-medical costs borne by the government and patients. The cost of the interventions will be calculated by the ingredients approach, in which the total quantities of goods and services actually employed in applying the interventions will be estimated, and multiplied by their respective unit prices. Relevant information on costs of interventions will be obtained mainly from administrative records. The costs borne by patients will be collected via exit and telephone interviews. An annual discount rate of 8% will be used, consistent with the rate recommended by the Government of Chile. All costs will be converted from Chilean Peso to US dollars with the 2007 average period exchange rate of US$1 = 522.37 Chilean Peso. To test the robustness of model results, we will vary the assumptions over a plausible range in sensitivity analyses. Discussion The protocol described here indicates our intent to conduct an economic evaluation alongside the CENEX study. It provides a detailed and transparent statement of planned data collection methods and analyses. Trial registration ISRCTN48153354 PMID:19473513

  17. In-Factory Learning - Qualification For The Factory Of The Future

    NASA Astrophysics Data System (ADS)

    Quint, Fabian; Mura, Katharina; Gorecky, Dominic

    2015-07-01

    The Industry 4.0 vision anticipates that internet technologies will find their way into future factories replacing traditional components by dynamic and intelligent cyber-physical systems (CPS) that combine the physical objects with their digital representation. Reducing the gap between the real and digital world makes the factory environment more flexible, more adaptive, but also more complex for the human workers. Future workers require interdisciplinary competencies from engineering, information technology, and computer science in order to understand and manage the diverse interrelations between physical objects and their digital counterpart. This paper proposes a mixed-reality based learning environment, which combines physical objects and visualisation of digital content via Augmented Reality. It uses reality-based interaction in order to make the dynamic interrelations between real and digital factory visible and tangible. We argue that our learning system does not work as a stand-alone solution, but should fit into existing academic and advanced training curricula.

  18. A Distribution-Free Multi-Factorial Profiler for Harvesting Information from High-Density Screenings

    PubMed Central

    Besseris, George J.

    2013-01-01

    Data screening is an indispensable phase in initiating the scientific discovery process. Fractional factorial designs offer quick and economical options for engineering highly-dense structured datasets. Maximum information content is harvested when a selected fractional factorial scheme is driven to saturation while data gathering is suppressed to no replication. A novel multi-factorial profiler is presented that allows screening of saturated-unreplicated designs by decomposing the examined response to its constituent contributions. Partial effects are sliced off systematically from the investigated response to form individual contrasts using simple robust measures. By isolating each time the disturbance attributed solely to a single controlling factor, the Wilcoxon-Mann-Whitney rank stochastics are employed to assign significance. We demonstrate that the proposed profiler possesses its own self-checking mechanism for detecting a potential influence due to fluctuations attributed to the remaining unexplainable error. Main benefits of the method are: 1) easy to grasp, 2) well-explained test-power properties, 3) distribution-free, 4) sparsity-free, 5) calibration-free, 6) simulation-free, 7) easy to implement, and 8) expanded usability to any type and size of multi-factorial screening designs. The method is elucidated with a benchmarked profiling effort for a water filtration process. PMID:24009744

  19. Diamond Growth in the Subduction Factory

    NASA Astrophysics Data System (ADS)

    Bureau, H.; Frost, D. J.; Bolfan-Casanova, N.; Leroy, C.; Estève, I.

    2014-12-01

    Natural diamonds are fabulous probes of the deep Earth Interior. They are the evidence of the deep storage of volatile elements, carbon at first, but also hydrogen and chlorine trapped as hydrous fluids in inclusions. The study of diamond growth processes in the lithosphere and mantle helps for our understanding of volatile elements cycling between deep reservoirs. We know now that inclusion-bearing diamonds similar to diamonds found in nature (i.e. polycrystalline, fibrous and coated diamonds) can grow in hydrous fluids or melts (Bureau et al., GCA 77, 202-214, 2012). Therefore, we propose that the best environment to promote such diamonds is the subduction factory, where highly hydrous fluids or melts are present. When oceanic plates are subducted in the lithosphere, they carry an oceanic crust soaked with seawater. While the slabs are traveling en route to the mantle, dehydration processes generate saline fluids highly concentrated in NaCl. In the present study we have experimentally shown that diamonds can grow from the saline fluids (up to 30 g/l NaCl in water) generated in subducted slabs. We have performed multi-anvil press experiments at 6-7 GPa and from 1300 to 1400°C during 6:00 hours to 30:00 hours. We observed large areas of new diamond grown in epitaxy on pure diamond seeds in salty hydrous carbonated melts, forming coated gems. The new rims are containing multi-component primary inclusions. Detailed characterizations of the diamonds and their inclusions have been performed and will be presented. These experimental results suggest that multi-component salty fluids of supercritical nature migrate with the slabs, down to the deep mantle. Such fluids may insure the first stage of the deep Earth's volatiles cycling (C, H, halogen elements) en route to the transition zone and the lower mantle. We suggest that the subduction factory may also be a diamond factory.

  20. Survey and Alignment of SLAC's B Factory

    SciTech Connect

    Pietryka, Matthew J.; Gaydosh, Michael L.; /SLAC

    2011-09-08

    The survey and alignment of SLAC's B-factory injector and high energy ring will be complete in March 1997. Modern digital electronic surveying tools are contributing to new, efficient alignment procedures. A laser tracker was used to fiducialize almost 300 quadrupole magnets. Digital levels were used to pre-set base plate elevations. Theodolites with very accurate co-axial distance meters were used for everything from layout to 3D magnet positioning to network surveys, all in free stationing mode. A number of procedures and measurement results are outlined.

  1. Object Classification at the Nearby Supernova Factory

    SciTech Connect

    Aragon, Cecilia R.; Bailey, Stephen; Aragon, Cecilia R.; Romano, Raquel; Thomas, Rollin C.; Weaver, B. A.; Wong, D.

    2007-12-21

    We present the results of applying new object classification techniques to the supernova search of the Nearby Supernova Factory. In comparison to simple threshold cuts, more sophisticated methods such as boosted decision trees, random forests, and support vector machines provide dramatically better object discrimination: we reduced the number of nonsupernova candidates by a factor of 10 while increasing our supernova identification efficiency. Methods such as these will be crucial for maintaining a reasonable false positive rate in the automated transient alert pipelines of upcoming large optical surveys.

  2. Microbial Cell Factories for Diol Production.

    PubMed

    Sabra, W; Groeger, C; Zeng, An-Ping

    2016-01-01

    Diols are compounds with two hydroxyl groups and have a wide range of appealing applications as chemicals and fuels. In particular, five low molecular diol compounds, namely 1,3-propanediol (1,3-PDO), 1,2-propanediol (1,2-PDO), 2,3-butanediol (2,3-BDO), 1,3-butanediol (1,3-BDO), and 1,4-butanediol (1,4-BDO), can be biotechnologically produced by direct microbial bioconversion of renewable materials. In this review, we summarize recent developments in the microbial production of diols, especially regarding the engineering of typical microbial strains as cell factory and the development of corresponding bioconversion processes. PMID:26475465

  3. The Personal Software Process: Downscaling the factory

    NASA Technical Reports Server (NTRS)

    Roy, Daniel M.

    1994-01-01

    It is argued that the next wave of software process improvement (SPI) activities will be based on a people-centered paradigm. The most promising such paradigm, Watts Humphrey's personal software process (PSP), is summarized and its advantages are listed. The concepts of the PSP are shown also to fit a down-scaled version of Basili's experience factory. The author's data and lessons learned while practicing the PSP are presented along with personal experience, observations, and advice from the perspective of a consultant and teacher for the personal software process.

  4. Resin Dermatitis in a Car Factory

    PubMed Central

    Engel, H. O.; Calnan, C. D.

    1966-01-01

    An outbreak of dermatitis in a car assembly factory is described; it affected 50 workers who handled rubber weatherstrips coated with an adhesive. The adhesive was found to contain para-tertiary butyl phenol (P.T.B.P.) formaldehyde resin. Of those patch tested 70% gave positive reactions to the adhesive and 65% to the resin. Improved methods of handling and personal protection succeeded in arresting the occurrence of dermatitis. Barrier creams gave no protection in these circumstances. The episode illustrates the different preventive control methods which have to be tried when dealing with a simple skin hazard which cannot be abolished. Images PMID:5904100

  5. Wake Fields in the Super B Factory Interaction Region

    SciTech Connect

    Weathersby, Stephen; Novokhatski, Alexander; /SLAC

    2011-06-02

    The geometry of storage ring collider interaction regions present an impedance to beam fields resulting in the generation of additional electromagnetic fields (higher order modes or wake fields) which affect the beam energy and trajectory. These affects are computed for the Super B interaction region by evaluating longitudinal loss factors and averaged transverse kicks for short range wake fields. Results indicate at least a factor of 2 lower wake field power generation in comparison with the interaction region geometry of the PEP-II B-factory collider. Wake field reduction is a consderation in the Super B design. Transverse kicks are consistent with an attractive potential from the crotch nearest the beam trajectory. The longitudinal loss factor scales as the -2.5 power of the bunch length. A factor of 60 loss factor reduction is possible with crotch geometry based on an intersecting tubes model.

  6. Accelerator R&D toward Muon Collider and Neutrino Factory

    SciTech Connect

    Shiltsev, Vladimir; /Fermilab

    2009-10-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture, accelerate and collide high intensity beams of muons. At present, a high-luminosity multi-TeV muon collider presents a viable option for the next generation lepton-lepton collider, which is believed to be needed to fully explore high energy physics in the era following LHC discoveries. Such a collider can offer superb energy resolution, smaller size, and potentially cost and power consumption compared to multi-TeV e{sup +}e{sup -} linear colliders. This article briefly reviews the motivation, design and status of accelerator R&D for Muon Collider and Neutrino Factory.

  7. Formulation of wax oxybenzone microparticles using a factorial approach.

    PubMed

    Gomaa, Y A; Darwish, I A; Boraei, N A; El-Khordagui, L K

    2010-01-01

    Oxybenzone wax microparticles (MPs) were prepared by the hydrophobic congealable disperse phase method. The formulation of oxybenzone-loaded MPs was optimized using a 2⁴ experimental design. Factorial analysis indicated that the main MP characteristics were influenced by initial drug loading, emulsification speed, emulsifier concentration and hydrophilic-lipophilic balance. MPs were spherical with 50.5–88.1 μm size range, 17.8–38.9 drug content in mg/100 mg MPs and 33.1–87.2% oxybenzone release in 1 h. A wide range of sunscreen delivery systems suitable for different formulation purposes were generated which may contribute to the advanced formulation of sunscreen products with improved performance. PMID:20681744

  8. Investigation of an Asymmetric B Factory in the PEP Tunnel

    SciTech Connect

    Chattapadhyay, A.; Hitlin, D.; Porter, F.; Chin, Y.H.; Dell'Orco, D.; Forest, E.; Furman, M.; Garren, A.A.; Hearty, C.; Jacob, A.; Kennedy, K.; Kim, K.; Lambertson, G.; Oddone, P.; Ronan, M.; Sessler, A.; Taylor, C.; Voelker, F.; Zisman, M.; Barletta, W.; Allen, M.; Bane, K.; Bloom, E.; Brenkus, F.; Brown, K.; Corbett, J.; Cornacchia, M.; Coupal, D.; Davies-White, W.; DeStaebler, H.; Donald, M.; Dorfan, J.; Hsu, I.; Hutton, A.; Jenkins, T.; Kozanecki, W.; Lisin, A.; Loew, G.; Miller, R.; Morton, P.; Pellegrin, J.-L.; Raubenheimer, T.; Rees, J.; Ritson, D.; Ruth, R.; Saab, A.; Savage, W.; Schwarz, H.; Seeman, J.; Thompson, K.; Weidner, H.; Wilson, P.; Sullivan, M.; Jackson, G.; Hertzbach, S.; Tennyson, J.; Zholents, A.; Fitze, H.

    1990-03-01

    This report addresses the feasibility of designing and constructing an asymmetric B-factory based on the PEP storage ring at SLAC that can begin operation at a luminosity of 3 X 10{sup 33} cm{sup -2}s{sup -1} and could ultimately reach even higher luminosity. Such a facility, operating at the {gamma}(4S) resonance, could be used to study mixing, rare decays, and CP violation in the B{bar B} system, and could also study tau and charm physics. The essential accelerator physics, engineering and technology issues that must be addressed to successfully build this exciting and challenging facility are identified, and possible solutions, or R and D activities that will reasonable lead to such solutions, are described.

  9. Feasibility Study for an Asymmetric B Factory Based on PEP

    SciTech Connect

    Chattapadhyay, A.; Hitlin, D.; Porter, F.; Chin, Y.H.; Dell'Orco, D.; Forest, E.; Furman, M.; Garren, A.A.; Hoyer, E.; Kennedy, K.; Lambertson, G.; Lo, C.C.; Nishimura, H.; Oddone, P.; Ronan, M.; Sessler, A.; Taylor, B.; Taylor, C.; Zisman, M.; Barletta, W.; Allen, M.; Bloom, E.; Burke, D.; Cornacchia, M.; Davies-White, D.; Destaebler, H.; Donald, M.H.; Dorfan, J.; Feldman, G.; Rees, J.; Schsarz, H.; Sullivan, M.; Autin, B.; Tennyson, J.; Barbson, B.; Oide, K.

    1989-10-26

    This report addresses the feasibility of designing and constructing an asymmetric B-factory based on the PEP storage ring at SLAC that can ultimately reach a luminosity of 1 X 10{sup 34} cm{sup -2}s{sup -1}. Such a facility, operating at the {gamma}(4S) resonance, could be used to study mixing, rate decays, and CP violation in the B{bar B} system, and could also study tau and charm physics. The essential accelerator physics, engineering, and technology issues that must be addressed to successfully build this exciting and challenging facility are identified, and possible solutions, or R and D that will reasonable lead to such solutions, are described.

  10. Factory acceptance test results for the DIRSP projection optics

    NASA Astrophysics Data System (ADS)

    Thomas, Matthew C.; Ward, Craig S.

    2000-07-01

    The Factory Acceptance Test (FAT) results for the projection optical subsystem (POS) of US Army STIRCOM's dynamic infrared scene projector (DIRSP) are presented in this paper. DIRSP is a low background (-35 degrees Celsius) hardware-in-the- loop (HWIL), long-wave infrared (LWIR) scene projector built by Mission Research Corporation (MRC) for use by the Redstone Technical Test Center (RTTC). It has an effective emitter array size of 1632 X 672 suspended-membrane micro-resistor elements. The POS is responsible for generating this effective array size from three smaller arrays using a mosaic image combiner, adding background light from an external blackbody, and collimating the combined radiation with a 5:1 vacuum enclosed -35 degree Celsius zoom lens. The FAT results reported demonstrate good POS performance compared to the design for focal length, F/#, MTF and apparent temperature.

  11. Accelerator R&D toward Muon Collider and Neutrino Factory

    NASA Astrophysics Data System (ADS)

    Shiltsev, V.

    2010-12-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture, accelerate and collide high intensity beams of muons. At present, a high-luminosity multi-TeV muon collider presents a viable option for the next generation lepton-lepton collider, which is believed to be needed to fully explore high energy physics in the era following LHC discoveries. Such a collider can offer superb energy resolution, smaller size, and potentially cost and power consumption compared to multi-TeV e + e - linear colliders. This article briefly reviews the motivation, design and status of accelerator R&D for Muon Collider and Neutrino Factory.

  12. A factorial snowpack model (FSM 1.0)

    NASA Astrophysics Data System (ADS)

    Essery, R.

    2015-12-01

    A model for the coupled mass and energy balances of snow on the ground requires representations of absorption of solar radiation by snow, heat conduction in snow, compaction of snow, transfer of heat to snow from the air and retention and refreezing of meltwater in snow. Many such models exist, but it has proven hard to relate their relative performances to the complexity of their process representations. This paper describes the systematic development of an open-source snowpack model with two levels of representation for each of the five processes mentioned above, allowing factorial experimental designs with 32 different model configurations. The model is demonstrated using driving and evaluation data recorded over one winter at an alpine site.

  13. A Factorial Snowpack Model (FSM 1.0)

    NASA Astrophysics Data System (ADS)

    Essery, R.

    2015-08-01

    A model for the coupled mass and energy balances of snow on the ground requires representations of absorption of solar radiation by snow, heat conduction in snow, compaction of snow, transfer of heat to snow from the air, and retention and refreezing of meltwater in snow. Many such models exist, but it has proven hard to relate their relative performances to the complexity of their process representations. This paper describes the systematic development of an open-source snowpack model with two levels of representation for each of the five processes mentioned above, allowing factorial experimental designs with 32 different model configurations. The model is demonstrated using driving and evaluation data recorded over one winter at an alpine site.

  14. Lattice Commissioning Stretgy Simulation for the B Factory

    SciTech Connect

    Lee, M.; Whittum, D.; Yan, Y.; Cai, Y.; Shoaee, H.; /SLAC

    2011-08-26

    To prepare for the PEP-II turn on, we have studied one commissioning strategy with simulated lattice errors. Features such as difference and absolute orbit analysis and correction are discussed. To prepare for the commissioning of the PEP-II injection line and high energy ring (HER), we have developed a system for on-line orbit analysis by merging two existing codes: LEGO and RESOLVE. With the LEGO-RESOLVE system, we can study the problem of finding quadrupole alignment and beam position (BPM) offset errors with simulated data. We have increased the speed and versatility of the orbit analysis process by using a command file written in a script language designed specifically for RESOLVE. In addition, we have interfaced the LEGO-RESOLVE system to the control system of the B-Factory. In this paper, we describe online analysis features of the LEGO-RESOLVE system and present examples of practical applications.

  15. Optical Design of WFIRST-AFTA Wide-Field Instrument

    NASA Technical Reports Server (NTRS)

    Pasquale, Bert; Content, Dave; Kruk, Jeffrey; Vaughn, David; Gong, Qian; Howard, Joseph; Jurling, Alden; Mentzell, Eric; Armani, Nerses; Kuan, Gary

    2014-01-01

    The WFIRSTAFTA Wide-Field Infrared Survey Telescope TMA optical design provides 0.28-sq FOV at 0.11 pixel scale, operating between 0.6 2.4m, including a spectrograph mode (1.3-1.95m.) An IFU provides a discrete 3x3.15 field at 0.15 sampling.

  16. Parameters for a Super-Flavor-Factory

    SciTech Connect

    Seeman, J.T.; Cai, Y.; Ecklund, S.; Novokhatski, A.; Seryi, A.; Sullivan, M.; Wienands, U.; Biagini, M.; Raimondi, P.; /Frascati

    2006-06-27

    A Super Flavor Factory, an asymmetric energy e{sup +}e{sup -} collider with a luminosity of order 10{sup 36} cm{sup -2} s{sup -1}, can provide a sensitive probe of new physics in the flavor sector of the Standard Model. The success of the PEP-II and KEKB asymmetric colliders in producing unprecedented luminosity above 10{sup 34} cm{sup -2} s{sup -1} has taught us about the accelerator physics of asymmetric e{sup +}e{sup -} collider in a new parameter regime. Furthermore, the success of the SLAC Linear Collider and the subsequent work on the International Linear Collider allow a new Super-Flavor collider to also incorporate linear collider techniques. This note describes the parameters of an asymmetric Flavor-Factory collider at a luminosity of order 10{sup 36} cm{sup -2} s{sup -1} at the Y(4S) resonance and about 10{sup 35} cm{sup -2} s{sup -1} at the {tau} production threshold. Such a collider would produce an integrated luminosity of about 10,000 fb{sup -1} (10 ab{sup -1}) in a running year (10{sup 7} sec) at the Y(4S) resonance. In the following note only the parameters relative to the Y(4S) resonance will be shown, the ones relative to the lower energy operations are still under study.

  17. Quarkonium States at B-Factories

    SciTech Connect

    Robutti, Enrico; /INFN, Genoa

    2011-11-21

    An overview is given on recent progress in the study of quarkonium spectroscopy at the B-factories. In particular, an updated status report is presented of the long list of 'charmonium-like' resonances newly discovered, whose assignment as true charmonium states is in most cases at least controversial. Also, new measurements on the decay properties of bottomonium states above open-B production thresholds are shown. Much of the progress attained in recent years in the study of the quarkonium spectra is owed to the measurements performed at B-factories. The impressive amount of data recorded by the BABAR and Belle experiments has made it possible to study rare decay chains and to look for as yet undiscovered resonances in the charmonium and bottomonium mass regions. Results presented here are based on different subsamples of the full datasets recorded up to now by the two experiments, corresponding to integrated luminosities of about 430 fb{sup -1}(BABAR - final) and about 850 fb{sup -1}(Belle). Significant contributions also come from the analysis of the various data samples recorded by the CLEO detector.

  18. 4. NORTH REAR OF FACTORY BUILDING, LOOKING SOUTH, SHOWING SHED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. NORTH REAR OF FACTORY BUILDING, LOOKING SOUTH, SHOWING SHED ADDITION FOR WELL-SERVICE VEHICLE, TOOLS, AND EQUIPMENT AND REAR ENTRANCE DOOR AND WINDOW INTO FACTORY. THE METAL OUTBUILDING IN THE LEFT FOREGROUND IS A SHOP-BUILT PRIVY ERECTED OVER A SANITARY SEWER. VISIBLE ON THE ROOF ARE TWO SKYLIGHT STRUCTURES AND FLUES FOR FORGE AND HEATING STOVE. THE BUILDING ON THE LEFT IS AN ADJACENT GROCERY STORE. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  19. Carbonate factories: A conundrum in sedimentary geology

    NASA Astrophysics Data System (ADS)

    Pomar, L.; Hallock, P.

    2008-03-01

    by the end-Permian extinctions, excess photosynthesis by phytoplankton and microbial assemblages in surface waters, induced by moderately high CO 2 and temperature during the Early Mesozoic, supported proliferation of non-tissular metazoans (e.g., sponges) and heterotrophic bacteria at the sea floor. Metabolic activity by those microbes, especially sulfate reduction, resulted in abundant biologically-induced geochemical carbonate precipitation on and within the sea floor. For example, with the opening of Tethyan seaways during the Triassic, massive sponge/microbe boundstones (the benthic automicrite factory) formed steep, massive and thick progradational slopes and, locally, mud-mounds. As tectonic processes created shallow epicontinental seas, photosynthesis drove lime-mud precipitation in the illuminated zone of the water column. The resulting neritic lime-mud component of the shallow-water carbonate factory became predominant during the Jurassic, paralleling the increase in atmospheric pCO 2, while the decreasing importance of the benthic automicrite factory parallels the diversification of calcifying metazoans, phytoplankton and zooplankton. With atmospheric pCO 2 declining through the Cretaceous, the potential habitats for neritic lime-mud precipitation declined. At the same time, peak oceanic Ca 2+ concentrations promoted biotically-controlled calcification by the skeletal factory. With changes produced by extinctions and turnovers at the Cretaceous-Tertiary boundary, adaptations to decreasing Ca 2+ and pCO 2, coupled with increasing global temperature gradients (i.e., high-latitude and deep-water cooling), and strategies that efficiently linked photosynthesis and calcification, promoted successive changes of the dominant skeletal factory through the Cenozoic: larger benthic foraminifers (protist-protist symbiosis) during the Paleogene, red algae during the Miocene and modern coral reefs (metazoan-protist symbiosis) since Late Miocene.

  20. Synthesis Structure Property Relations in Layered, Li-excess Oxides Electrode Materials Li[Li1/3-2x/3NixMn2/3-x/3]O2 (x=1/3, 1/4 and 1/5)

    SciTech Connect

    Fell, Christopher; Carroll, Kyler; Chi, Miaofang; Meng, Ying Shirley

    2010-01-01

    Relations between synthesis conditions, detailed crystal structures, and electrochemical properties of the Li-excess layered oxides Li[Ni{sub x}Li{sub 1/3-2x/3}Mn{sub 2/3-x/3}]O{sub 2}(0 < x < 1/2) are studied by X-ray diffraction, scanning electron microscopy (EELS), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), and electron energy-loss spectrometry, combined with electrochemical property measurements including potentiostatic intermittent titration technique (PITT). Optimal synthesis conditions are obtained for stoichiometric samples sintered at 1000 C in air followed by furnace cooling. The materials exhibit capacities of {approx}250, 230, and 200 mAh/g within a voltage range of 2-4.8 V on discharge for x = 1/5, 1/4 and 1/3, respectively. Diffraction data of electrochemically cycled electrode materials show an expanded c/a lattice ratio and changing Li/Ni interlayer mixing indicating peculiar cation migration in the structures. High resolution TEM images and XPS spectra show obvious differences in the surface characteristics of the samples synthesized with stoichiometric and excess amount of LiOH, suggesting that surface characteristics is one of the contributing factors to the difference in electrochemical properties. Our results suggest that the first cycle irreversible capacity is affected by both the bulk and surface characteristics of pristine materials, which is strongly influenced by precursor chemistry. The PITT results suggest that cation rearrangement during the charge/discharge has a significant impact on the lithium chemical diffusivity.

  1. Vacuum system of the high energy ring of an asymmetric B-factory based on PEP

    SciTech Connect

    Barletta, W.A.; Calderon, M.O.; Wong, R. ); Jenkins, T.M. )

    1991-05-07

    The multi-ampere currents required for high luminosity operation of an asymmetric B factory leads to extremely stressing requirements on a vacuum system suitable for maintaining long beam-gas lifetimes and acceptable background levels in the detector. We present the design for a Cu alloy vacuum chamber and its associated pumping system for the 9 GeV electron storage ring of the proposed B factory based on PEP. The excellent thermal and photo-desorption properties of Cu allows handling the high proton flux in a conventional, single chamber design with distributed ion pumps. The x-ray opacity of the Cu is sufficiently high that no additional lead shielding is necessary to protect the dipoles from the intense synchrotron radiation generated by the beam. The design allows chamber commissioning in <500 hr of operation. 5 refs., 3 figs., 2 tabs.

  2. Intense muon beams and neutrino factories

    SciTech Connect

    Parsa, Z.

    2000-10-05

    High intensity muon sources are needed in exploring neutrino factories, lepton flavor violating muon processes, and lower energy experiments as the stepping phase towards building higher energy {mu}{sup +}{mu}{sup {minus}} colliders. We present a brief overview, sketch of a neutrino source, and an example of a muon storage ring at BNL with detector(s) at Fermilab, Sudan, etc. Physics with low energy neutrino beams based on muon storage rings ({mu}SR) and conventional Horn Facilities are described and compared. CP violation Asymmetries and a new Statistical Figure of Merit to be used for comparison is given. Improvements in the sensitivity of low energy experiments to study Flavor changing neutral currents are also included.

  3. [Shoe factory workers, solvents and health].

    PubMed

    Foà, Vito; Martinotti, Irene

    2012-01-01

    Exposure to organic solvents in footwear manufacturing industry came from the glues used adhering the shoe parts to each other. Benzene was the first solvent used in shoe factories until the evidence of its capacity to cause leukaemia. Then, the demonstration that exposure to n-hexane was related to distal polyneuropathy limited the use of this substance. After that, results of neurotoxicological studies conducted on workers exposed to different mixtures of organic solvents make necessary prevention measure directed to a progressive reduction of air dispersion of these chemicals. Today exposure to solvents in workplaces is regulated by health based exposure limit values that should warranty absence of central nervous system effects. One of the most important rules of occupational medicine is verify that these exposure levels are really health protective also for workers with increased susceptibility. PMID:22697025

  4. Rapid and high-throughput construction of microbial cell-factories with regulatory noncoding RNAs.

    PubMed

    Chaudhary, Amit Kumar; Na, Dokyun; Lee, Eun Yeol

    2015-11-01

    Due to global crises such as pollution and depletion of fossil fuels, sustainable technologies based on microbial cell-factories have been garnering great interest as an alternative to chemical factories. The development of microbial cell-factories is imperative in cutting down the overall manufacturing cost. Thus, diverse metabolic engineering strategies and engineering tools have been established to obtain a preferred genotype and phenotype displaying superior productivity. However, these tools are limited to only a handful of genes with permanent modification of a genome and significant labor costs, and this is one of the bottlenecks associated with biofactory construction. Therefore, a groundbreaking rapid and high-throughput engineering tool is needed for efficient construction of microbial cell-factories. During the last decade, copious small noncoding RNAs (ncRNAs) have been discovered in bacteria. These are involved in substantial regulatory roles like transcriptional and post-transcriptional gene regulation by modulating mRNA elongation, stability, or translational efficiency. Because of their vulnerability, ncRNAs can be used as another layer of conditional control over gene expression without modifying chromosomal sequences, and hence would be a promising high-throughput tool for metabolic engineering. Here, we review successful design principles and applications of ncRNAs for high-throughput metabolic engineering or physiological studies of diverse industrially important microorganisms. PMID:26027891

  5. An rf cavity for the B-Factory

    SciTech Connect

    Rimmer, R.; Voelker, F.; Lambertson, G. ); Allen, M.; Hodgeson, J.; Ko, K.; Pendleton, R.; Schwarz, H. ); Kroll, N. Stanford Linear Accelerator Center, Menlo Park, CA )

    1991-04-01

    The paper describes the proposed design for the 476 MHz accelerating cavity for the SLAC/LBL/LLNL B-Factory. This machine will require a high power throughput to the beam because of the large synchrotron radiation losses, and very low impedances for the higher order modes because of the high current proposed. Use of conventional construction in copper means that careful consideration has to be paid to the problem of cooling. The need for a high shunt impedance for the accelerating mode dictated the use of a re-entrant shape. This maximized the impedance of the fundamental mode with respect to the troublesome longitudinal and deflecting higher order modes, when compared to open or bell shaped'' designs. A specialized damping scheme was employed to reduce the higher order mode impedances while sacrificing as little of the fundamental mode power as possible. This was required to suppress the growth of coupled bunch beam instabilities and minimize the workload of the feedback system needed to control them. A window design capable of handling the high power was also required. 8 refs., 1 fig., 2 tabs.

  6. 27 CFR 40.70 - Separation of and access to factory.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... to factory. 40.70 Section 40.70 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... § 40.70 Separation of and access to factory. Where the factory consists of a portion of a building, or where portions of buildings are part of the factory, the factory shall be completely separated by...

  7. 27 CFR 40.70 - Separation of and access to factory.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... to factory. 40.70 Section 40.70 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... § 40.70 Separation of and access to factory. Where the factory consists of a portion of a building, or where portions of buildings are part of the factory, the factory shall be completely separated by...

  8. 27 CFR 40.70 - Separation of and access to factory.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to factory. 40.70 Section 40.70 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... § 40.70 Separation of and access to factory. Where the factory consists of a portion of a building, or where portions of buildings are part of the factory, the factory shall be completely separated by...

  9. Advanced Envelope Research for Factory Built Housing, Phase 3. Whole-House Prototyping

    SciTech Connect

    Levy, E.; Mullens, M.; Rath, P.

    2014-04-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective envelope designs that can be effectively integrated into the plant production process while meeting the thermal requirements of the 2012 IECC standards. This work is part of a multiphase effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three methods for building high performance walls. Phase 2 focused on developing viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped narrow the research focus to perfecting a stud wall design with exterior continuous insulation (CI). This report describes Phase 3, which was completed in two stages and continued the design development effort, exploring and evaluating a range or methods for applying CI to factory built homes. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing. During this phase, a home was built with CI, evaluated, and placed in service. The experience of building a mock up wall section with CI and then constructing on line a prototype home resolved important concerns about how to integrate the material into the production process. First steps were taken toward finding least expensive approaches for incorporating CI in standard factory building practices and a preliminary assessment suggested that even at this early stage the technology is attractive when viewed from a life cycle cost perspective.

  10. Advanced Envelope Research for Factory Built Housing, Phase 3 -- Whole-House Prototyping

    SciTech Connect

    Levy, E.; Mullens, M.; Rath, P.

    2014-04-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective envelope designs that can be effectively integrated into the plant production process while meeting the thermal requirements of the 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing new envelope technologies. This work is part of a multi-phase effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three methods for building high performance walls. Phase 2 focused on developing viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped narrow the research focus to perfecting a stud wall design with exterior continuous insulation (CI). Phase 3, completed in two stages, continued the design development effort, exploring and evaluating a range or methods for applying CI to factory built homes. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing. During this phase, a home was built with CI, evaluated, and placed in service. The experience of building a mock up wall section with CI and then constructing on line a prototype home resolved important concerns about how to integrate the material into the production process. First steps were taken toward finding least expensive approaches for incorporating CI in standard factory building practices and a preliminary assessment suggested that even at this early stage the technology is attractive when viewed from a life cycle cost perspective.

  11. Congruences for central factorial numbers modulo powers of prime.

    PubMed

    Wang, Haiqing; Liu, Guodong

    2016-01-01

    Central factorial numbers are more closely related to the Stirling numbers than the other well-known special numbers, and they play a major role in a variety of branches of mathematics. In the present paper we prove some interesting congruences for central factorial numbers. PMID:27047725

  12. Perspective view. Fivestory reinforced concrete factory building reveals the structural ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective view. Five-story reinforced concrete factory building reveals the structural frame on the exterior of the facade. Twelve bay facade facing onto Clay Avenue (north facade) has first floor openings bricked up. Mix of typical factory windows and glass block windows fill the majority of the openings on the rest of building - Russell Industrial Center, 1600 Clay Avenue, Detroit, MI

  13. 27 CFR 40.47 - Other businesses within factory.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Other businesses within... AND TUBES, AND PROCESSED TOBACCO Administrative Provisions § 40.47 Other businesses within factory. (a) General. The appropriate TTB officer may authorize such other businesses within the factory of...

  14. 27 CFR 40.47 - Other businesses within factory.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Other businesses within... AND TUBES, AND PROCESSED TOBACCO Administrative Provisions § 40.47 Other businesses within factory. (a) General. The appropriate TTB officer may authorize such other businesses within the factory of...

  15. Superconducting final focus quadrupoles for a B Factory

    SciTech Connect

    Ash, W.

    1992-08-01

    The superconducting final focus triplet now operating at the SLAC Linear Collider (SLC) demonstrate most of the features required for a B Factory in terms of detector interaction and high machine tolerances. These features are discussed, together with reasonable expectations for scaling to a B Factory. The effort and schedule for this project are discussed.

  16. 13. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING SOUTHEAST. THIS SECTION OF THE FACTORY WAS USED FOR STORAGE; TO THE LEFT IS AN ELECTRIC MOTOR SUSPENDED FROM A COLLAR BEAM. - Illinois Pure Aluminum Company, 109 Holmes Street, Lemont, Cook County, IL

  17. 11. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING NORTHWEST. THIS SECTION OF THE FACTORY WAS USED FOR STORAGE; THE STAIRWAY LEADS DOWN TO THE SECOND FLOOR WHICH WAS THE LOCATION OF THE COMPANY OFFICE AND EMPLOYEE CHANGE ROOM. - Illinois Pure Aluminum Company, 109 Holmes Street, Lemont, Cook County, IL

  18. 12. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING NORTHEAST. THIS SECTION OF THE FACTORY WAS USED FOR STORAGE; CENTRAL LINE SHAFTING EXTENDS ALONG THE CENTER ROW OF COLUMNS. - Illinois Pure Aluminum Company, 109 Holmes Street, Lemont, Cook County, IL

  19. The Cupcake Factory: Helping Elementary Students Understand Economics.

    ERIC Educational Resources Information Center

    Yeargan, Howard; Hatcher, Barbara

    1985-01-01

    Described is a project in which third graders create their own corporation--a cupcake factory--and learn first-hand about economic principles and the decisions that businesses must make in the market economy. The cupcake factory is one example of how enterprising educators can make economics comprehensible and captivating. (RM)

  20. 46 CFR 162.050-13 - Factory production and inspection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Factory production and inspection. 162.050-13 Section 162.050-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION....050-13 Factory production and inspection. (a) Equipment manufactured under Coast Guard approval...

  1. Students Tackle Academics in Practical Context at Skateboard Factory

    ERIC Educational Resources Information Center

    Pearson, George

    2012-01-01

    High school student Nick Robertson came to Oasis Skateboard Factory (OSF) from a suburban Toronto district. He was surfing the web when he spotted a reference to Oasis Skateboard Factory, an alternative program in the Toronto District School Board. He says his first reaction was "Skateboards in school? It didn't seem possible." He applied, was…

  2. Factorial Invariance in Multiple Populations: A Multiple Testing Procedure

    ERIC Educational Resources Information Center

    Raykov, Tenko; Marcoulides, George A.; Millsap, Roger E.

    2013-01-01

    A multiple testing method for examining factorial invariance for latent constructs evaluated by multiple indicators in distinct populations is outlined. The procedure is based on the false discovery rate concept and multiple individual restriction tests and resolves general limitations of a popular factorial invariance testing approach. The…

  3. Factorial Invariance of a Pan-Hispanic Familism Scale

    ERIC Educational Resources Information Center

    Villarreal, Ricardo; Blozis, Shelley A.; Widaman, Keith F.

    2005-01-01

    This article considers the validity and factorial invariance of an attitudinal measure of familism. Using a large, nationally representative sample of U.S. Hispanics, the validity and factorial invariance of the measure was tested across country of origin (United States, Mexico, and Latin America) and the language in which the survey was conducted…

  4. Touschek Background and Lifetime Studies for the SuperB Factory

    SciTech Connect

    Boscolo, M.; Biagini, M.; Raimondi, P.; Sullivan, M.; Paoloni, E.; /INFN, Pisa

    2010-08-26

    The novel crab waist collision scheme under test at the DA{Phi}NE Frascati {Phi}-factory finds its natural application to the SuperB project, the asymmetric e{sup +}e{sup -} flavour factory at very high luminosity with relatively low beam currents and reduced backgrounds. The SuperB accelerator design requires a careful choice of beam parameters to reach a good trade-off between different effects. We present here simulation results for the Touschek backgrounds and lifetime obtained for both the low and high energy rings for different machine designs. A first set of horizontal collimators has been studied to stop Touschek particles. A study of the distributions of the Touschek particle losses at the interaction region into the detectors for further investigations is underway.

  5. A factorial-design cluster randomised controlled trial investigating the cost-effectiveness of a nutrition supplement and an exercise programme on pneumonia incidence, walking capacity and body mass index in older people living in Santiago, Chile: the CENEX study protocol

    PubMed Central

    Dangour, Alan D; Albala, Cecilia; Aedo, Cristian; Elbourne, Diana; Grundy, Emily; Walker, Damian; Uauy, Ricardo

    2007-01-01

    Background Chile is currently undergoing a period of rapid demographic transition which has led to an increase in the proportion of older people in the population; the proportion aged 60 years and over, for example, increased from 8% of the population in 1980 to 12% in 2005. In an effort to promote healthy ageing and preserve function, the government of Chile has formulated a package of actions into the Programme of Complementary Feeding for the Older Population (PACAM) which has been providing a nutritional supplement to older people since 1998. PACAM distributes micronutrient fortified foods to individuals aged 70 years and over registered at Primary Health Centres and enrolled in the programme. The recommended serving size (50 g/day) of these supplements provides 50% of daily micronutrient requirements and 20% of daily energy requirements of older people. No information is currently available on the cost-effectiveness of the supplementation programme. Aim The aim of the CENEX cluster randomised controlled trial is to evaluate the cost-effectiveness of an ongoing nutrition supplementation programme, and a specially designed physical exercise intervention for older people of low to medium socio-economic status living in Santiago, Chile. Methods The study has been conceptualised as a public health programme effectiveness study and has been designed as a 24-month factorial cluster-randomised controlled trial conducted among 2800 individuals aged 65.0–67.9 years at baseline attending 28 health centres in Santiago. The main outcomes are incidence of pneumonia, walking capacity and change in body mass index over 24 months of intervention. Costing data (user and provider), collected at all levels, will enable the determination of the cost-effectiveness of the two interventions individually and in combination. The study is supported by the Ministry of Health in Chile, which is keen to expand and improve its national programme of nutrition for older people based on

  6. Neutrino factory and beta beam: accelerator options for future neutrino experiments

    SciTech Connect

    Zisman, Michael S.

    2012-06-03

    Two accelerator options for producing intense neutrino beams a Neutrino Factory based on stored muon beams and a Beta Beam facility based on stored beams of beta unstable ions are described. Technical challenges for each are described and current R&D efforts aimed at mitigating these challenges are indicated. Progress is being made in the design of both types of facility, each of which would extend the state-of-the-art in accelerator science.

  7. Space-Charge Effects in the Super B-Factory LER

    SciTech Connect

    Venturini, Marco

    2007-01-31

    Space-charge effects in the low-energy ring of the proposedSuper-B Factory are studied using a weak-strong model of dynamics asimplemented in the code Marylie/Impact (MLI). The impact of space chargeappears noticeable but our results suggest the existence of workableregions of the tune space where the design emittance is minimallyaffected. However, additional studies are recommended to fullysubstantiate this conclusion.

  8. Crabbed Waist Collisions in DAFNE and Super-B Design

    SciTech Connect

    Raimondi, P.; Alesini, D.; Biagini, M.E.; Biscari, C.; Boni, R.; Boscolo, M.; Bossi, F.; Buonomo, B.; Clozza, A.; Delle Monache, G.O.; Demma, T.; Di Pasquale, E.; Di Pirro, G.; Drago, A.; Gallo, A.; Ghigo, A.; Guiducci, S.; Ligi, C.; Marcellini, F.; Mazzitelli, Giovanni; Milardi, C.; /Frascati /Orsay, LAL /CERN /Rome III U. /Rome U. /Novosibirsk, IYF /KEK, Tsukuba /INFN, Pisa /INFN, Cosenza /SLAC /Frascati

    2011-11-02

    The new idea of increasing the luminosity of a collider with crab waist collisions and first experimental results from the DA{Phi}NE {Phi}-Factory at LNF, Frascati, using this concept are presented. Consequences for the design of future factories will be discussed. An outlook to the performance reach with crab waist collisions is given, with emphasis on future B Factories.

  9. What's happening inside the subduction factory?

    NASA Astrophysics Data System (ADS)

    Penniston-Dorland, S. C.; Bebout, G. E.; Gorman, J. K.; Piccoli, P. M.; Walker, R. J.

    2012-12-01

    Much research has focused on the inputs and outputs of the 'subduction factory,' however a variety of metamorphic processes occur within the subducting slab and at its interface with the mantle wedge that contribute to creating the mixed signals observed in arc magmas. Subduction-related metamorphic rocks from the Catalina Schist represent a range of metamorphic grades and provide a natural laboratory to investigate these processes. Hybrid rock types such as reaction zones or 'rinds' between mafic (crustal) and ultramafic (mantle) rocks have attracted recent interest since they have a different bulk chemistry and mineralogy compared to the original inputs to the subduction factory. Here we explore the mineralogical and geochemical differences between the metamorphic rocks, their reaction zones, and endmember subduction input lithologies over a range of metamorphic grades including lawsonite albite, lawsonite blueschist, and amphibolite facies (with peak T ranging from ~ 275 to ~ 750°C and peak P ranging up to ~1.1 GPa). The results shed light on chemical changes occurring within the subduction zone and the processes happening inside the 'subduction factory', including mass transfer of elements by both fluid infiltration and mechanical mixing. Elements commonly enriched in arc magmatic rocks, such as the LILE (e.g. Ba, K), are enriched in metamafic rocks at all metamorphic grades relative to likely MORB protoliths. These enrichments are interpreted as the product of metamorphic fluid infiltration. Many major- and trace-element concentrations in reaction rinds fall between those of metamafic blocks and surrounding ultramafic-rich mélange matrix (including TiO2, MgO, FeO, Al2O3, Zr, Ni and Cr). Spatial distributions of these elements within the rinds suggest that the intermediate concentrations may be due to mechanical mixing of crustal and mantle materials. Rind concentrations of the highly siderophile elements (HSE: including Os, Ir, Ru, Pt, Pd, Re) as well as

  10. 77 FR 44593 - Burlington Coat Factory Warehouse Corporation, Provisional Acceptance of a Settlement Agreement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... COMMISSION Burlington Coat Factory Warehouse Corporation, Provisional Acceptance of a Settlement Agreement... accepted Settlement Agreement with Burlington Coat Factory Warehouse Corporation, containing a civil... Factory Warehouse Corporation CPSC Docket No. 12-C0008 Settlement Agreement 1. In accordance with...

  11. The Experience Factory: Strategy and Practice

    NASA Technical Reports Server (NTRS)

    Basili, Victor R.; Caldiera, Gianluigi

    1995-01-01

    The quality movement, that has had in recent years a dramatic impact on all industrial sectors, has recently reached the system and software industry. Although some concepts of quality management, originally developed for other product types, can be applied to software, its specificity as a product which is developed and not produced requires a special approach. This paper introduces a quality paradigm specifically tailored on the problem of the systems and software industry. Reuse of products, processes and experiences originating from the system life cycle is seen today as a feasible solution to the problem of developing higher quality systems at a lower cost. In fact, quality improvement is very often achieved by defining and developing an appropriate set of strategic capabilities and core competencies to support them. A strategic capability is, in this context, a corporate goal defined by the business position of the organization and implemented by key business processes. Strategic capabilities are supported by core competencies, which are aggregate technologies tailored to the specific needs of the organization in performing the needed business processes. Core competencies are non-transitional, have a consistent evolution, and are typically fueled by multiple technologies. Their selection and development requires commitment, investment and leadership. The paradigm introduced in this paper for developing core competencies is the Quality Improvement Paradigm which consists of six steps: (1) Characterize the environment, (2) Set the goals, (3) Choose the process, (4) Execute the process, (5) Analyze the process data, and (6) Package experience. The process must be supported by a goal oriented approach to measurement and control, and an organizational infrastructure, called Experience Factory. The Experience Factory is a logical and physical organization distinct from the project organizations it supports. Its goal is development and support of core competencies

  12. An integrated information support system for the factory floor of an ammunition manufacturing plant

    SciTech Connect

    Schroeder, J.O.; Badalamente, R.V.; Crow, V.L.

    1988-11-01

    An integrated information support system provides information processing and management on the factory floor of an ammunition manufacturing plant. The system is designed as a distributed network of minicomputers, process control computers and personal computer workstations that interactively update a complex relational database. The system controls and analyzes production,quality, and maintenance functions. Attention to human factors engineering during design has resulted in minimum training time and high user acceptance. The paper presents the system's life-cycle history and a critique of the implementation approach and system design. 3 refs., 4 figs.

  13. Factory daughters, the family, and nuptiality in Java.

    PubMed

    Wolf, D L

    1990-01-01

    The commercialization of agriculture, increasing landlessness, and an expanding labor class in rural areas of Java are all the result of industrialization. This work discusses the effect of female employment on marriage patterns of women working in rural factories. The central point is that employment has not only increased the financial autonomy of these women, but also increased the level of control they have over the choice of marriage partners. The data set used for analysis consisted of the observations of all factory workers and all non-factory females age 15-24 located in an agricultural village. The observations were make over a 15 month period between 1981-83. A follow up visit was made in 1986 and the following conclusions were then made: 1) the village study gave detailed data, but the data set was not large enough, thus a follow up study that encompasses more people is called for; 2) young rural female factory workers are more likely to chose their marriage partners than those engaged in traditional village labor. Of those that married and worked in factories, their fertility rate was significantly lower, compared to non-factory workers. Factory workers also had different family structures, because they spent less time living in extended families because of a larger income for the couple. This study indicates that increased economic control results in increased life decision control. This changed the daughter's economic relationship with her family and gives her more control in marriage decisions. PMID:12343333

  14. VLBA Reveals Dust-Enshrouded "Supernova Factory"

    NASA Astrophysics Data System (ADS)

    2003-05-01

    Using the National Science Foundation's Very Long Baseline Array (VLBA) radio telescope, astronomers have discovered a newly-exploded star, or supernova, hidden deep in a dust-enshrouded "supernova factory" in a galaxy some 140 million light-years from Earth. "This supernova is likely to be part of a group of super star clusters that produce one such stellar explosion every two years," said James Ulvestad, of the National Radio Astronomy Observatory (NRAO) in Socorro, NM. "We're extremely excited by the tremendous insights into star formation and the early Universe that we may gain by observing this 'supernova factory,'" he added. Ulvestad worked with Susan Neff of NASA's Goddard Space Flight Center in Greenbelt, MD, and Stacy Teng, a graduate student at the University of Maryland, on the project. The scientists presented their findings to the American Astronomical Society's meeting in Nashville, TN. "These super star clusters likely are forming in much the same way that globular clusters formed in the early Universe, and thus provide us with a unique opportunity to learn about how some of the first stars formed billions of years ago," Neff said. The cluster is in an object called Arp 299, a pair of colliding galaxies, where regions of vigorous star formation have been found in past observations. Since 1990, four other supernova explosions have been seen optically in Arp 299. Observations with the NSF's Very Large Array (VLA) earlier showed a region near the nucleus of one of the colliding galaxies which had all the earmarks of prolific star formation. The astronomers focused on this region, prosaically dubbed "Source A," with the VLBA and the NSF's Robert C. Byrd Green Bank Telescope in 2002, and found four objects in this dusty cloud that are likely young supernova remnants. When they observed the region again in February 2003, there was a new, fifth, object located only 7 light-years from one of the previously detected objects. More observations on April 30-May

  15. Lidar/DIAL detection of bomb factories

    NASA Astrophysics Data System (ADS)

    Fiorani, Luca; Puiu, Adriana; Rosa, Olga; Palucci, Antonio

    2013-10-01

    One of the aims of the project BONAS (BOmb factory detection by Networks of Advanced Sensors) is to develop a lidar/DIAL (differential absorption lidar) to detect precursors employed in the manufacturing of improvised explosive devices (IEDs). At first, a spectroscopic study has been carried out: the infrared (IR) gas phase spectrum of acetone, one of the more important IED precursors, has been procured from available databases and checked with cell measurements. Then, the feasibility of a lidar/DIAL for the detection of acetone vapors has been shown in laboratory, simulating the experimental conditions of a field campaign. Eventually, having in mind measurements in a real scenario, an interferent study has been performed, looking for all known compounds that share with acetone IR absorption in the spectral band selected for its detection. Possible interfering species were investigated, simulating both urban and industrial atmospheres and limits of acetone detection in both environments were identified. This study confirmed that a lidar/DIAL can detect low concentration of acetone at considerable distances.

  16. Future Accelerators, Muon Colliders, and Neutrino Factories

    SciTech Connect

    Richard A Carrigan, Jr.

    2001-12-19

    Particle physics is driven by five great topics. Neutrino oscillations and masses are now at the fore. The standard model with extensions to supersymmetry and a Higgs to generate mass explains much of the field. The origins of CP violation are not understood. The possibility of extra dimensions has raised tantalizing new questions. A fifth topic lurking in the background is the possibility of something totally different. Many of the questions raised by these topics require powerful new accelerators. It is not an overstatement to say that for some of the issues, the accelerator is almost the experiment. Indeed some of the questions require machines beyond our present capability. As this volume attests, there are parts of the particle physics program that have been significantly advanced without the use of accelerators such as the subject of neutrino oscillations and many aspects of the particle-cosmology interface. At this stage in the development of physics, both approaches are needed and important. This chapter first reviews the status of the great accelerator facilities now in operation or coming on within the decade. Next, midrange possibilities are discussed including linear colliders with the adjunct possibility of gamma-gamma colliders, muon colliders, with precursor neutrino factories, and very large hadron colliders. Finally visionary possibilities are considered including plasma and laser accelerators.

  17. Cell as a factory for humanized encapsulation

    NASA Astrophysics Data System (ADS)

    Mao, Zhengwei; Wang, Dayang

    2012-03-01

    Variety efforts are being made to develop colloidal based drug delivery systems (DDSs), which encapsulate cytotoxic drug in a vehicle and release them in a controlled manner. However, the synthetic carriers developed thus far are hampered by rapidly clearance in the body, for example by phagocytes, possibly due to the non-natural surface characteristics in terms of chemistry, morphology, and mechanics. To circumvent this important challenge, we have exploited living mammalian cells as factories to encapsulate drugs in "natural vesicles". These natural vesicles are termed cell membrane capsules (CMCs), because they maintain the major membrane structure and functions as well as cytosolic proteins of the parental cells. We demonstrate that CMCs act as unique delivery vehicles, in which encapsulated substances can be processed stepwise by cellular enzymes and then be selectively released through protein channels built-in the membrane, in a controlled and sustained manner. The preliminary study investigating the macrophage response to CMCs indicated the potential of CMCs to avoid attack by the immune system.

  18. Efficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: OLmesartan rosuvaSTAtin from Daewoong).

    PubMed

    Park, Jin-Sun; Shin, Joon-Han; Hong, Taek-Jong; Seo, Hong-Seog; Shim, Wan-Joo; Baek, Sang-Hong; Jeong, Jin-Ok; Ahn, Youngkeun; Kang, Woong-Chol; Kim, Young-Hak; Kim, Sang-Hyun; Hyon, Min-Su; Choi, Dong-Hoon; Nam, Chang-Wook; Park, Tae-Ho; Lee, Sang-Chol; Kim, Hyo-Soo

    2016-01-01

    The pill burden of patients with hypertension and dyslipidemia can result in poor medication compliance. This study aimed to evaluate the efficacy and safety of fixed-dose combination (FDC) therapy with olmesartan medoxomil (40 mg) and rosuvastatin (20 mg) in Korean patients with mild to moderate hypertension and dyslipidemia. This multicenter, randomized, double-blind, factorial-design study included patients aged ≥20 years with mild to moderate essential hypertension and dyslipidemia. Patients were randomly assigned to receive FDC therapy (40 mg olmesartan medoxomil, 20 mg rosuvastatin), 40 mg olmesartan medoxomil, 20 mg rosuvastatin, or a placebo. The percentage change from baseline in low-density lipoprotein cholesterol levels was compared between FDC therapy and olmesartan medoxomil, and the change from baseline in diastolic blood pressure was compared between FDC therapy and rosuvastatin 8 weeks after treatment. A total of 162 patients were included. The least square mean percentage change (standard error) from baseline in low-density lipoprotein cholesterol levels 8 weeks after treatment was significantly greater in the FDC than in the olmesartan medoxomil group (-52.3% [2.8%] vs -0.6% [3.5%], P<0.0001), and the difference was -51.7% (4.1%) (95% confidence interval: -59.8% to -43.6%). The least square mean change (standard error) from baseline in diastolic blood pressure 8 weeks after treatment was significantly greater in the FDC group than in the rosuvastatin group (-10.4 [1.2] mmHg vs 0.1 [1.6] mmHg, P<0.0001), and the difference was -10.5 (1.8) mmHg (95% confidence interval: -14.1 to -6.9 mmHg). There were 50 adverse events in 41 patients (22.7%) and eight adverse drug reactions in five patients (2.8%). The study found that FDC therapy with olmesartan medoxomil and rosuvastatin is an effective, safe treatment for patients with hypertension and dyslipidemia. This combination may improve medication compliance in patients with a large pill burden. PMID

  19. Efficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: OLmesartan rosuvaSTAtin from Daewoong)

    PubMed Central

    Park, Jin-Sun; Shin, Joon-Han; Hong, Taek-Jong; Seo, Hong-Seog; Shim, Wan-Joo; Baek, Sang-Hong; Jeong, Jin-Ok; Ahn, Youngkeun; Kang, Woong-Chol; Kim, Young-Hak; Kim, Sang-Hyun; Hyon, Min-Su; Choi, Dong-Hoon; Nam, Chang-Wook; Park, Tae-Ho; Lee, Sang-Chol; Kim, Hyo-Soo

    2016-01-01

    The pill burden of patients with hypertension and dyslipidemia can result in poor medication compliance. This study aimed to evaluate the efficacy and safety of fixed-dose combination (FDC) therapy with olmesartan medoxomil (40 mg) and rosuvastatin (20 mg) in Korean patients with mild to moderate hypertension and dyslipidemia. This multicenter, randomized, double-blind, factorial-design study included patients aged ≥20 years with mild to moderate essential hypertension and dyslipidemia. Patients were randomly assigned to receive FDC therapy (40 mg olmesartan medoxomil, 20 mg rosuvastatin), 40 mg olmesartan medoxomil, 20 mg rosuvastatin, or a placebo. The percentage change from baseline in low-density lipoprotein cholesterol levels was compared between FDC therapy and olmesartan medoxomil, and the change from baseline in diastolic blood pressure was compared between FDC therapy and rosuvastatin 8 weeks after treatment. A total of 162 patients were included. The least square mean percentage change (standard error) from baseline in low-density lipoprotein cholesterol levels 8 weeks after treatment was significantly greater in the FDC than in the olmesartan medoxomil group (−52.3% [2.8%] vs −0.6% [3.5%], P<0.0001), and the difference was −51.7% (4.1%) (95% confidence interval: −59.8% to −43.6%). The least square mean change (standard error) from baseline in diastolic blood pressure 8 weeks after treatment was significantly greater in the FDC group than in the rosuvastatin group (−10.4 [1.2] mmHg vs 0.1 [1.6] mmHg, P<0.0001), and the difference was −10.5 (1.8) mmHg (95% confidence interval: −14.1 to −6.9 mmHg). There were 50 adverse events in 41 patients (22.7%) and eight adverse drug reactions in five patients (2.8%). The study found that FDC therapy with olmesartan medoxomil and rosuvastatin is an effective, safe treatment for patients with hypertension and dyslipidemia. This combination may improve medication compliance in patients with a large

  20. Energy conservation through recycling of factory asphalt roofing waste

    SciTech Connect

    Shepherd, P.B.; Powers, T.J. . Manville Technical Center); Hardy, J.; Maloof, R.; Patenaude, C.; Zilfi, J. )

    1989-12-31

    Prior DOE laboratory research showed that it was possible to recover the energy resource represented in factory shingle waste. This waste could be processed and recycled into the asphalt composition used to make new shingles. This bench-scale research concluded that factory experiments were all that were needed to provide a basis for commercial implementation. The project reported here completed that full scale research. Factory fiber glass shingle waste was processed to a form suitable for recycling. The processed waste was then mixed into the asphalt used to make new shingles. Process parameters and shingle quality were measured to provide a basis for commercial implementation.

  1. The Factorial Validity of The Maslach Burnout Inventory--General Survey in Representative Samples of Eight Different Occupational Groups

    ERIC Educational Resources Information Center

    Langballe, Ellen Melbye; Falkum, Erik; Innstrand, Siw Tone; Aasland, Olaf Gjerlow

    2006-01-01

    The Maslach Burnout Inventory--General Survey (MBI-GS) is designed to measure the three subdimensions (exhaustion, cynicism, and professional efficacy) of burnout in a wide range of occupations. This article examines the factorial validity of the MBI-GS across eight different occupational groups in Norway: lawyers, physicians, nurses, teachers,…

  2. Combustion of liquid paint wastes in fluidized bed boiler as element of waste management system in the paint factory

    SciTech Connect

    Soko, W.A.; Biaecka, B.

    1998-12-31

    In this paper the solution to waste problems in the paint industry is presented by describing their combustion in a fluidized bed boiler as a part of the waste management system in the paint factory. Based on the Cleaner Production idea and concept of integration of design process with a future exploitation of equipment, some modifications of the waste management scheme in the factory are discussed to reduce the quantity of toxic wastes. To verify this concept combustion tests of paint production wastes and cocombustion of paint wastes with coal in an adopted industrial boiler were done. Results of these tests are presented in the paper.

  3. Numerical study of a magnetically insulated front-end channel for a neutrino factory

    SciTech Connect

    Stratakis, D.; Fernow, R.; Gallardo, J.; Palmer, R.; Neuffer, D.

    2011-02-14

    A neutrino factory, which can deliver an intense flux of {approx}10{sup 21} neutrinos per year from a multi-GeV stored muon beam, is seemingly the ideal tool for studying neutrino oscillations and CP violations for leptons. The front end of this facility plays a critical role in determining the number of muons that can be accepted by the downstream accelerators. Delivering peak performance requires transporting the muon beams through long sections of a beam channel containing high-gradient rf cavities and strong focusing solenoids. Here, we propose a novel scheme to improve the performance of the cavities, thereby increasing the number of muons within the acceptance of the accelerator chain. The key element of our new scheme is to apply a tangential magnetic field to the rf surfaces, thus forcing any field-emitted electrons to return to the surface before gaining enough energy to damage the cavity. We incorporate this idea into a new lattice design for a neutrino factory, and detail its performance numerically. Although our proposed front-end channel requires more rf power than conventional pillbox designs, it provides enough beam cooling and muon production to be a feasible option for a neutrino factory.

  4. Assessment of Tooth Wear Among Glass Factory Workers: WHO 2013 Oral Health Survey

    PubMed Central

    Bhat, Nagesh; Asawa, Kailash; Tak, Mridula; Bapat, Salil; Gupta, Vivek Vardhan

    2015-01-01

    Background Glass factory workers are often exposed to the hazardous environment that leads to deleterious oral health and subsequently, general health. We planned to determine the effects of the particulates present in the milieu on the tooth wear among workers. Aim To assess tooth wear among glass factory workers in Jaipur, Rajasthan, India. Settings and Design A descriptive cross-sectional survey was conducted among 936 glass workers in Jaipur, Rajasthan, India from January-June 2014. Materials and Methods A survey proforma was designed for tooth wear evaluation with the help of WHO Oral Health Assessment form 2013 (for adults). Information regarding oral health practices, adverse habits and dietary habits, demographic details was gathered and clinical parameters were recorded. Statistical Analysis The Chi–square test, t–test, One-way Analysis of Variance and a Stepwise multiple linear regression analysis. Results The most prevalent form of erosion was enamel erosion (589, 62.93%) with few subjects of deeper dentinal erosion and the difference was statistically significant (p=0.001). Dental erosion was found to be higher among males compared to females. Years of experience and educational status were identified as best predictors for dental erosion. Conclusion It was concluded that there was considerable evidence of dental erosion found among the factory workers. Due to ignorance on social, cultural and health aspects, professional approach with regular dental care services for detection of early symptoms and planning of preventive strategies is warranted. PMID:26436050

  5. Down sampled signal processing for a B Factory bunch-by-bunch feedback system

    SciTech Connect

    Hindi, H.; Hosseini, W.; Briggs, D.; Fox, J.; Hutton, A.

    1992-03-01

    A bunch-by-bunch feedback scheme is studied for damping coupled bunch synchrotron oscillations in the proposed PEP II B Factory. The quasi-linear feedback systems design incorporates a phase detector to provide a quantized measure of bunch phase, digital signal processing to compute an error correction signal and a kicker system to correct the energy of the bunches. A farm of digital processors, operating in parallel, is proposed to compute correction signals for the 1658 bunches of the B Factory. This paper studies the use of down sampled processing to reduce the computational complexity of the feedback system. We present simulation results showing the effect of down sampling on beam dynamics. Results show that down sampled processing can reduce the scale of the processing task by a factor of 10.

  6. 1. VIEW LOOKING SOUTHWEST AT PARTIAL EAST ELEVATION OF FACTORY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW LOOKING SOUTHWEST AT PARTIAL EAST ELEVATION OF FACTORY, SHOWING FORMER OHIO & ERIE CANAL PRISM IN FOREGROUND THAT WAS USED AS WATER RESERVOIR (500,000 GALLON) - Jaite Paper Mill, 1200 West Highland Road, Sagamore Hills, Summit County, OH

  7. Factorial kriging analysis applied to geological data from petroleum exploration

    SciTech Connect

    Jaquet, O.

    1989-10-01

    A regionalized variable, thickness of the reservoir layer, from a gas field is decomposed by factorial kriging analysis. Maps of the obtained components may be associated with depositional environments that are favorable for petroleum exploration.

  8. Neutrino Factory Accelerator R&D: Status and Priorities

    SciTech Connect

    Zisman, Michael S.

    2005-08-23

    This paper summarizes the status of worldwide Neutrino Factory R&D efforts. Activities are categorized as simulations, component development, and system tests. An indication of R&D tasks that remain to be accomplished is also given.

  9. Lead levels of Culex mosquito larvae inhabiting lead utilizing factory

    PubMed Central

    Kitvatanachai, S; Apiwathnasorn, C; Leemingsawat, S; Wongwit, W; Overgaard, HJ

    2011-01-01

    Objective To determine lead level primarily in Culex quinquefasciatus (Cx. quinquefasciatus), and Culex gelidus (Cx. gelidus) larvae inhabiting lead consuming factories, and to putatively estimate eco-toxicological impact of effluents from the firms. Methods Third instars larvae were sampled by standard dipping method and lead concentrations in the larvae and their respective surrounding factory aquatic environments were determined through standard atomic absorption spectrophotometry (AAS). Results Cx. quinquefasciatus was the most abundant species followed by Cx. gelidus. The levels of lead were higher in the Cx. quinquefasciatus (1.08-47.47 µg/g), than in the wastewaters surface (0.01-0.78 µg/mL) from the factories or closer areas around factories. Other species were not reaching the criteria for lead determination. Conclusions The Cx. quinquefasciatus larvae can bio-accumulate the metal and can potentially serve as a biomarker of lead contamination, to complemente conventional techniques. PMID:23569727

  10. Application of fiber laser for a Higgs factory

    SciTech Connect

    Chou, W.

    2014-06-04

    This paper proposes a medium size(~6km) circular Higgs factory based on a photon collider. The recent breakthrough in fiber laser technology by means of a coherent amplifier network makes such a collider feasible and probably also affordable.

  11. Three-dimensional structure of Rubella virus factories

    SciTech Connect

    Fontana, Juan; Lopez-Iglesias, Carmen; Tzeng, Wen-Ping; Frey, Teryl K.; Fernandez, Jose J.; Risco, Cristina

    2010-09-30

    Viral factories are complex structures in the infected cell where viruses compartmentalize their life cycle. Rubella virus (RUBV) assembles factories by recruitment of rough endoplasmic reticulum (RER), mitochondria and Golgi around modified lysosomes known as cytopathic vacuoles or CPVs. These organelles contain active replication complexes that transfer replicated RNA to assembly sites in Golgi membranes. We have studied the structure of RUBV factory in three dimensions by electron tomography and freeze-fracture. CPVs contain stacked membranes, rigid sheets, small vesicles and large vacuoles. These membranes are interconnected and in communication with the endocytic pathway since they incorporate endocytosed BSA-gold. RER and CPVs are coupled through protein bridges and closely apposed membranes. Golgi vesicles attach to the CPVs but no tight contacts with mitochondria were detected. Immunogold labelling confirmed that the mitochondrial protein p32 is an abundant component around and inside CPVs where it could play important roles in factory activities.

  12. 2. EAST ELEVATION OF IPA FACTORY; TWOSTORY SECTION BUILT IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. EAST ELEVATION OF IPA FACTORY; TWO-STORY SECTION BUILT IN 1892 AND PARTIALLY DESTROYED PARAPET SECTION BUILT CA. 1948. BRICK CHIMNEY ALSO BUILT CA. 1948. - Illinois Pure Aluminum Company, 109 Holmes Street, Lemont, Cook County, IL

  13. Pion production for neutrino factories and muon colliders

    SciTech Connect

    Mokhov, N.V.; Guidman, K.K.; Strait, J.B.; Striganov, S.I.; /Fermilab

    2009-12-01

    Optimization of pion and muon production/collection for neutrino factories and muon colliders is described along with recent developments of the MARS15 code event generators and effects influencing the choice of the optimal beam energy.

  14. 18. 1925 Main Factory building, interior, second floor, view looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. 1925 Main Factory building, interior, second floor, view looking northeast at opening in the floor for dropping warp rolls - North Star Woolen Mill, 109 Portland Avenue South, Minneapolis, Hennepin County, MN

  15. Collective effects in the PEP-II B-factory

    SciTech Connect

    Corlett, J.N.

    1995-10-01

    The expected major collective effects in the PEP-II B-factory are discussed and thresholds presented. Broadband and narrow band impedance values are reviewed. Instabilities not related to impedance are discussed.

  16. 19. 1925 Main Factory building, interior, view of second floor's ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. 1925 Main Factory building, interior, view of second floor's permutit room, view looking east showing water treatment tanks - North Star Woolen Mill, 109 Portland Avenue South, Minneapolis, Hennepin County, MN

  17. 21. 1925 Main Factory building, interior, second floor, view inside ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. 1925 Main Factory building, interior, second floor, view inside bobbin elevator shaft looking west showing conveyor for bobbin boxes - North Star Woolen Mill, 109 Portland Avenue South, Minneapolis, Hennepin County, MN

  18. 20. 1925 Main Factory building, interior, second floor, view inside ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. 1925 Main Factory building, interior, second floor, view inside bobbin elevator shaft looking east showing conveyor for jackspools - North Star Woolen Mill, 109 Portland Avenue South, Minneapolis, Hennepin County, MN

  19. Make your company a talent factory.

    PubMed

    Ready, Douglas A; Conger, Jay A

    2007-06-01

    Despite the great sums of money companies dedicate to talent management systems, many still struggle to fill key positions - limiting their potential for growth in the process. Virtually all the human resource executives in the authors' 2005 survey of 40 companies around the world said that their pipeline of high-potential employees was insufficient to fill strategic management roles. The survey revealed two primary reasons for this. First, the formal procedures for identifying and developing next-generation leaders have fallen out of sync with what companies need to grow or expand into new markets. To save money, for example, some firms have eliminated positions that would expose high-potential employees to a broad range of problems, thus sacrificing future development opportunities that would far outweigh any initial savings from the job cuts. Second, HR executives often have trouble keeping top leaders' attention on talent issues, despite those leaders' vigorous assertions that obtaining and keeping the best people is a major priority. If passion for that objective doesn't start at the top and infuse the culture, say the authors, talent management can easily deteriorate into the management of bureaucratic routines. Yet there are companies that can face the future with confidence. These firms don't just manage talent, they build talent factories. The authors describe the experiences of two such corporations - consumer products icon Procter & Gamble and financial services giant HSBC Group -that figured out how to develop and retain key employees and fill positions quickly to meet evolving business needs. Though each company approached talent management from a different direction, they both maintained a twin focus on functionality (rigorous talent processes that support strategic and cultural objectives) and vitality (management's emotional commitment, which is reflected in daily actions). PMID:17580649

  20. The Experiment Factory: Standardizing Behavioral Experiments

    PubMed Central

    Sochat, Vanessa V.; Eisenberg, Ian W.; Enkavi, A. Zeynep; Li, Jamie; Bissett, Patrick G.; Poldrack, Russell A.

    2016-01-01

    The administration of behavioral and experimental paradigms for psychology research is hindered by lack of a coordinated effort to develop and deploy standardized paradigms. While several frameworks (Mason and Suri, 2011; McDonnell et al., 2012; de Leeuw, 2015; Lange et al., 2015) have provided infrastructure and methods for individual research groups to develop paradigms, missing is a coordinated effort to develop paradigms linked with a system to easily deploy them. This disorganization leads to redundancy in development, divergent implementations of conceptually identical tasks, disorganized and error-prone code lacking documentation, and difficulty in replication. The ongoing reproducibility crisis in psychology and neuroscience research (Baker, 2015; Open Science Collaboration, 2015) highlights the urgency of this challenge: reproducible research in behavioral psychology is conditional on deployment of equivalent experiments. A large, accessible repository of experiments for researchers to develop collaboratively is most efficiently accomplished through an open source framework. Here we present the Experiment Factory, an open source framework for the development and deployment of web-based experiments. The modular infrastructure includes experiments, virtual machines for local or cloud deployment, and an application to drive these components and provide developers with functions and tools for further extension. We release this infrastructure with a deployment (http://www.expfactory.org) that researchers are currently using to run a set of over 80 standardized web-based experiments on Amazon Mechanical Turk. By providing open source tools for both deployment and development, this novel infrastructure holds promise to bring reproducibility to the administration of experiments, and accelerate scientific progress by providing a shared community resource of psychological paradigms. PMID:27199843

  1. The Experiment Factory: Standardizing Behavioral Experiments.

    PubMed

    Sochat, Vanessa V; Eisenberg, Ian W; Enkavi, A Zeynep; Li, Jamie; Bissett, Patrick G; Poldrack, Russell A

    2016-01-01

    The administration of behavioral and experimental paradigms for psychology research is hindered by lack of a coordinated effort to develop and deploy standardized paradigms. While several frameworks (Mason and Suri, 2011; McDonnell et al., 2012; de Leeuw, 2015; Lange et al., 2015) have provided infrastructure and methods for individual research groups to develop paradigms, missing is a coordinated effort to develop paradigms linked with a system to easily deploy them. This disorganization leads to redundancy in development, divergent implementations of conceptually identical tasks, disorganized and error-prone code lacking documentation, and difficulty in replication. The ongoing reproducibility crisis in psychology and neuroscience research (Baker, 2015; Open Science Collaboration, 2015) highlights the urgency of this challenge: reproducible research in behavioral psychology is conditional on deployment of equivalent experiments. A large, accessible repository of experiments for researchers to develop collaboratively is most efficiently accomplished through an open source framework. Here we present the Experiment Factory, an open source framework for the development and deployment of web-based experiments. The modular infrastructure includes experiments, virtual machines for local or cloud deployment, and an application to drive these components and provide developers with functions and tools for further extension. We release this infrastructure with a deployment (http://www.expfactory.org) that researchers are currently using to run a set of over 80 standardized web-based experiments on Amazon Mechanical Turk. By providing open source tools for both deployment and development, this novel infrastructure holds promise to bring reproducibility to the administration of experiments, and accelerate scientific progress by providing a shared community resource of psychological paradigms. PMID:27199843

  2. New physics at a Super Flavor Factory

    SciTech Connect

    Browder, Thomas E.; Gershon, Tim; Pirjol, Dan; Soni, Amarjit; Zupan, Jure

    2009-10-15

    The potential of a Super Flavor Factory (SFF) for searches of new physics is reviewed. While very high luminosity B physics is assumed to be at the core of the program, its scope for extensive charm and {tau} studies are also emphasized. The possibility to run at the {Upsilon}(5S) is also discussed; in principle, this could provide very clean measurements of B{sub s} decays. The strength and reach of a SFF are most notably due to the possibility of examining an impressive array of very clean observables. The angles and the sides of the unitarity triangle can be determined with unprecedented accuracy. These serve as a reference for new physics (NP) sensitive decays such as B{sup +}{yields}{tau}{sup +}{nu}{sub {tau}} and penguin dominated hadronic decay modes, providing tests of generic NP scenarios with an accuracy of a few percent. Besides very precise studies of direct and time dependent CP asymmetries in radiative B decays and forward-backward asymmetry studies in B{yields}X{sub s}l{sup +}l{sup -} and numerous null tests using B, charm, and {tau} decays are also likely to provide powerful insights into NP. The dramatic increase in luminosity at a SFF will also open up entirely new avenues for probing NP observables, e.g., by allowing sensitive studies using theoretically clean processes such as B{yields}X{sub s}{nu}{nu}. The SFF is envisioned to be a crucial tool for essential studies of flavor in the CERN Large Hadron Collider era and will extend the reach of the Large Hadron Collider in many important ways.

  3. A Possible Hybrid Cooling Channel for a Neutrino Factory

    SciTech Connect

    Zisman, Michael S; Gallardo, Juan C.

    2010-05-17

    A Neutrino Factory requires an intense and well-cooled (in transverse phase space) muon beam. We discuss a hybrid approach for a linear 4D cooling channel consisting of high-pressure gas-filled RF cavities--potentially allowing high gradients without breakdown--and discrete LiH absorbers to provide the necessary energy loss that results in the required muon beam cooling. We report simulations of the channel performance and its comparison with the vacuum case; we also briefly discuss technical and safety issues associated with cavities filled with high-pressure hydrogen gas. Even with additional windows that might be needed for safety reasons, the channel performance is comparable to that of the original, all-vacuum Feasibility Study 2a channel on which our design is based. If tests demonstrate that the gas-filled RF cavities can operate effectively with an intense beam of ionizing particles passing through them, our approach would be an attractive way of avoiding possible breakdown problems with a vacuum RF channel.

  4. Supernova Discoveries from the Nearby Supernova Factory (SNfactory)

    DOE Data Explorer

    SNfactory International Collaboration,

    The Nearby Supernova Factory is an experiment designed to collect data on more Type Ia supernovae than have ever been studied in a single project before, and in so doing, to answer some fundamental questions about the nature of the universe. Type Ia supernovae are extraordinarily bright, remarkably uniform objects which make excellent "standard candles" for measuring the expansion rate of the universe. However, such stellar explosions are very rare, occurring only a couple of times per millenium in a typical galaxy, and remaining bright enough to detect only for a few weeks. Previous studies of Type Ia supernovae led to the discovery of the mysterious "dark energy" that is causing the universe to expand at an accelerating rate. To reduce the statistical uncertainties in previous experimental data, extensive spectral and photometric monitoring of more Type Ia supernovae is required. The SNfactory collaboration has built an automated system consisting of specialized software and custom-built hardware that systematically searches the sky for new supernovae, screens potential candidates, then performs multiple spectral and photometric observations on each supernova. These observations are stored in a database to be made available to supernova researchers world-wide for further study and analysis [copied from http://snfactory.lbl.gov/snf/snf-about.html]. Users must register and agree to the open access honor system. Finding charts are in FITS format and may not be accessible through normal browser settings.

  5. 9. NORTHEAST FROM SOUTH ENTRANCE ACROSS RECEIVING AREA OF FACTORY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. NORTHEAST FROM SOUTH ENTRANCE ACROSS RECEIVING AREA OF FACTORY PAST THE GLASS-ENCLOSED OFFICE TOWARD SHOP AREA. BESIDE THE VERTICAL POST ROOF SUPPORT IN THE LEFT FOREGROUND IS A SCALE AND DRAFTING TABLE. BESIDE THE OFFICE WALL ON THE RIGHT IS A SMALL SHOP REPAIR BENCH, WHILE ABOVE THE OFFICE WINDOWS ARE BOXES OF COMPANY MANUSCRIPT BUSINESS RECORDS. THE WELDED METAL PIPE RACK IS A MODERN INTRUSION. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  6. 12. SOUTH INSIDE FACTORY ALONG EAST WALL TO PARTS STORAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. SOUTH INSIDE FACTORY ALONG EAST WALL TO PARTS STORAGE SHELVES AND BINS OUTSIDE PARTITION WALL OF OFFICE. THE SOUTH PARTITION WALL IN THIS AREA IS FITTED WITH SHELVES COVERED WITH BOXES CONTAINING MANUSCRIPT COMPANY RECORDS. THE BENCH IN THE RIGHT FOREGROUND WAS USED FOR ATTACHING WROUGHT IRON CONNECTIONS TO THE ENDS OF WOODEN SUCKER RODS; THE WOODEN RODS WERE STORED ON THE RACKS ALONG THE EAST WALL OF THIS AREA. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  7. Flavor physics at Super B-factories era

    NASA Astrophysics Data System (ADS)

    Pakhlov, P.; Uglov, T.

    2016-02-01

    We review numerous results from the B-Factories, obtained last decade. They provide currently strong constraints on New Physics extensions beyond the Standard Model. We discuss the physics program at Super B-factory, a next generation asymmetric collider with the luminosity almost two orders of magnitude higher than those achieved at the existing colliders, and its capability in cooperation with LHC of new insights into New Physics phenomena.

  8. 15. SOUTH TOWARD FRONT OF FACTORY FROM PUMP REPAIR WORK ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. SOUTH TOWARD FRONT OF FACTORY FROM PUMP REPAIR WORK BENCH, SHOWING HAND SHEAR MOUNTED ON A CASTER-FITTED TREE STUMP, WOOD-BURNING HEATING STOVE, CIRCA 1900 MICHIGAN MACHINERY MFG. CO. PUNCH PRESS, AND PART OF CIRCA 1910 'THE RACINE' RECIPROCATING HACK SAW. THE WELDED STEEL PIPE RACK IN THE LEFT BACKGROUND IS A MODERN INTRUSION. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  9. [Factorial analysis of the Hamilton depression scale, II].

    PubMed

    Dreyfus, J F; Guelfi, J D; Ruschel, S; Blanchard, C; Pichot, P

    1981-04-01

    A factorial analysis (principal components with Varimax rotation) was performed on 85 ratings of the Hamilton Depression Rating Scale obtained in 1979-1980 on inpatients with a major depressive illness. Using a replicable statistical technique, 4 factors were obtained. These factors do not overlap with those obtain on a similar sample with a similar technique nor with those obtained by other authors. It thus appears that there is no such thing as a factorial structure of this scale. PMID:7305179

  10. Expert Meeting Report: Advanced Envelope Research for Factory Built Housing

    SciTech Connect

    Levy, E.; Mullens, M.; Tompos, E.; Kessler, B.; Rath, P.

    2012-04-01

    This report provides information about the expert meeting on advanced envelope research for factory built housing, hosted by the ARIES Collaborative on October 11, 2011, in Phoenix, Arizona. The goals of this meeting were to provide a comprehensive solution to the use of three previously selected advanced alternatives for factory-built wall construction, assess each option focusing on major issues relating to viability and commercial potential, and determine additional steps are required to reach this potential.

  11. Expert Meeting Report: Advanced Envelope Research for Factory Built Housing

    SciTech Connect

    Levy, E.; Mullens, M.; Tompos, E.; Kessler, B.; Rath, P.

    2012-04-01

    This report provides information about the Building America expert meeting on advanced envelope research for factory built housing, hosted by the ARIES Collaborative on October 11, 2011, in Phoenix, Arizona. The goals of this meeting were to provide a comprehensive solution to the use of three previously selected advanced alternatives for factory-built wall construction, assess each option focusing on major issues relating to viability and commercial potential, and determine additional steps are required to reach this potential.

  12. Microbial Consortia Engineering for Cellular Factories: in vitro to in silico systems

    PubMed Central

    Bernstein, Hans C; Carlson, Ross P

    2012-01-01

    This mini-review discusses the current state of experimental and computational microbial consortia engineering with a focus on cellular factories. A discussion of promising ecological theories central to community resource usage is presented to facilitate interpretation of consortial designs. Recent case studies exemplifying different resource usage motifs and consortial assembly templates are presented. The review also highlights in silico approaches to design and to analyze consortia with an emphasis on stoichiometric modeling methods. The discipline of microbial consortia engineering possesses a widely accepted potential to generate highly novel and effective bio-catalysts for applications from biofuels to specialty chemicals to enhanced mineral recovery. PMID:24688677

  13. SuperB: A High-Luminosity Asymmetric e+e- Super Flavor Factory

    SciTech Connect

    Bona, M.; /et al.

    2007-05-18

    We discuss herein the exciting physics program that can be accomplished with a very large sample of heavy quark and heavy lepton decays produced in the very clean environment of an e{sup +}e{sup -} collider; a program complementary to that of an experiment such as LHCb at a hadronic machine. It then presents the conceptual design of a new type of e{sup +}e{sup -} collider that produces a nearly two-order-of-magnitude increase in luminosity over the current generation of asymmetric B Factories. The key idea is the use of low emittance beams produced in an accelerator lattice derived from the ILC Damping Ring Design, together with a new collision region, again with roots in the ILC final focus design, but with important new concepts developed in this design effort. Remarkably, SuperB produces this very large improvement in luminosity with circulating currents and wallplug power similar to those of the current B Factories. There is clear synergy with ILC R&D; design efforts have already influenced one another, and many aspects of the ILC Damping Rings and Final Focus would be operationally tested at SuperB. Finally, the design of an appropriate detector, based on an upgrade of BABAR as an example, is discussed in some detail. A preliminary cost estimate is presented, as is an example construction timeline.

  14. Black hole as a wormhole factory

    NASA Astrophysics Data System (ADS)

    Kim, Sung-Won; Park, Mu-In

    2015-12-01

    There have been lots of debates about the final fate of an evaporating black hole and the singularity hidden by an event horizon in quantum gravity. However, on general grounds, one may argue that a black hole stops radiation at the Planck mass (ħc / G) 1 / 2 ∼10-5 g, where the radiated energy is comparable to the black hole's mass. And also, it has been argued that there would be a wormhole-like structure, known as "spacetime foam", due to large fluctuations below the Planck length (ħG /c3) 1 / 2 ∼10-33 cm. In this paper, as an explicit example, we consider an exact classical solution which represents nicely those two properties in a recently proposed quantum gravity model based on different scaling dimensions between space and time coordinates. The solution, called "Black Wormhole", consists of two different states, depending on its mass parameter M and an IR parameter ω: For the black hole state (with ωM2 > 1 / 2), a non-traversable wormhole occupies the interior region of the black hole around the singularity at the origin, whereas for the wormhole state (with ωM2 < 1 / 2), the interior wormhole is exposed to an outside observer as the black hole horizon is disappearing from evaporation. The black hole state becomes thermodynamically stable as it approaches the merging point where the interior wormhole throat and the black hole horizon merges, and the Hawking temperature vanishes at the exact merge point (with ωM2 = 1 / 2). This solution suggests the "Generalized Cosmic Censorship" by the existence of a wormhole-like structure which protects the naked singularity even after the black hole evaporation. One could understand the would-be wormhole inside the black hole horizon as the result of microscopic wormholes created by "negative" energy quanta which have entered the black hole horizon in Hawking radiation process; the quantum black hole could be a wormhole factory! It is found that this speculative picture may be consistent with the recent " ER

  15. A simple model for factory distribution: Historical effect in an industry city

    NASA Astrophysics Data System (ADS)

    Uehara, Takashi; Sato, Kazunori; Morita, Satoru; Maeda, Yasunobu; Yoshimura, Jin; Tainaka, Kei-ichi

    2016-02-01

    The construction and discontinuance processes of factories are complicated problems in sociology. We focus on the spatial and temporal changes of factories at Hamamatsu city in Japan. Real data indicate that the clumping degree of factories decreases as the density of factory increases. To represent the spatial and temporal changes of factories, we apply "contact process" which is one of cellular automata. This model roughly explains the dynamics of factory distribution. We also find "historical effect" in spatial distribution. Namely, the recent factories have been dispersed due to the past distribution during the period of economic bubble. This effect may be related to heavy shock in Japanese stock market.

  16. Optimization of image process parameters through factorial experiments using a flat panel detector

    NASA Astrophysics Data System (ADS)

    Norrman, Eva; Geijer, Håkan; Persliden, Jan

    2007-09-01

    In the optimization process of lumbar spine examinations, factorial experiments were performed addressing the question of whether the effective dose can be reduced and the image quality maintained by adjusting the image processing parameters. A 2k-factorial design was used which is a systematic and effective method of investigating the influence of many parameters on a result variable. Radiographic images of a Contrast Detail phantom were exposed using the default settings of the process parameters for lumbar spine examinations. The image was processed using different settings of the process parameters. The parameters studied were ROI density, gamma, detail contrast enhancement (DCE), noise compensation, unsharp masking and unsharp masking kernel (UMK). The images were computer analysed and an image quality figure (IQF) was calculated and used as a measurement of the image quality. The parameters with the largest influence on image quality were noise compensation, unsharp masking, unsharp masking kernel and detail contrast enhancement. There was an interaction between unsharp masking and kernel indicating that increasing the unsharp masking improved the image quality when combined with a large kernel size. Combined with a small kernel size however the unsharp masking had a deteriorating effect. Performing a factorial experiment gave an overview of how the image quality was influenced by image processing. By adjusting the level of noise compensation, unsharp masking and kernel, the IQF was improved to a 30% lower effective dose.

  17. Factorial Structure of the Brief Symptom Inventory (BSI)-18 among Chinese Drug Users

    PubMed Central

    Wang, Jichuan; Kelly, Brian C; Liu, Tieqiao; Zhang, Guanbai; Hao, Wei

    2013-01-01

    BACKGROUND Although the Brief Symptom Inventory-18 (BSI-18) has been widely used for mental health screenings in both clinical and non-clinical populations, the validation of its application to Chinese populations has been very limited. The objective of this research is to assess the factorial structure of the BSI-18 within a Chinese drug using population. METHODS AND RESULTS A total sample of 303 drug users recruited via Respondent Driven Sampling (RDS) from Changsha, China was used for the study. Our results show: 1) The BSI-18 item scores are highly skewed; 2) With dichotomous items measures (1-problem at least moderately caused respondent discomfort during the past week; 0-otherwise), our findings support the designed 3-factor solution of the BSI-18 (somatization, depression, and anxiety); 3) The BSI-18 has a hierarchical factorial structure with 3 first-order factors and an underlying second-order factor (general psychological distress); 4) Tentative support should also be given to a single dimension of general psychological distress in Chinese drug using populations. Our study recommends a useful alternative approach for evaluating the factorial structure of the BSI-18 – i.e. CFA with dichotomous item measures. Both the total BSI-18 score and the three subscales (SOM, DEP, and ANX) can be used in applications of the BSI-18. CONCLUSION Overall, our findings suggest the BSI-18 is useful with Chinese drug users, and shows potential for use with non-Western and substance using populations more generally. PMID:23906998

  18. Microbially induced and microbially catalysed precipitation: two different carbonate factories

    NASA Astrophysics Data System (ADS)

    Meister, Patrick

    2016-04-01

    The landmark paper by Schlager (2003) has revealed three types of benthic carbonate production referred to as "carbonate factories", operative at different locations at different times in Earth history. The tropical or T-factory comprises the classical platforms and fringing reefs and is dominated by carbonate precipitation by autotrophic calcifying metazoans ("biotically controlled" precipitation). The cool or C-factory is also biotically controlled but via heterotrophic, calcifying metazoans in cold and deep waters at the continental margins. A further type is the mud-mound or M-factory, where carbonate precipitation is supported by microorganisms but not controlled by a specific enzymatic pathway ("biotically induced" precipitation). How exactly the microbes influence precipitation is still poorly understood. Based on recent experimental and field studies, the microbial influence on modern mud mound and microbialite growth includes two fundamentally different processes: (1) Metabolic activity of microbes may increase the saturation state with respect to a particular mineral phase, thereby indirectly driving the precipitation of the mineral phase: microbially induced precipitation. (2) In a situation, where a solution is already supersaturated but precipitation of the mineral is inhibited by a kinetic barrier, microbes may act as a catalyser, i.e. they lower the kinetic barrier: microbially catalysed precipitation. Such a catalytic effect can occur e.g. via secreted polymeric substances or specific chemical groups on the cell surface, at which the minerals nucleate or which facilitate mechanistically the bonding of new ions to the mineral surface. Based on these latest developments in microbialite formation, I propose to extend the scheme of benthic carbonate factories of Schlager et al. (2003) by introducing an additional branch distinguishing microbially induced from microbially catalysed precipitation. Although both mechanisms could be operative in a M-factory

  19. Analysis of Interpersonal Communication Processes in Digital Factory Environments

    NASA Astrophysics Data System (ADS)

    Schütze, Jens; Baum, Heiko; Laue, Martin; Müller, Egon

    The paper outlines the scope of influence of digital factory on the interpersonal communication process and the exemplary description of them. On the basis of a brief description about the theoretical basic concepts of the digital factory occurs the illustration of communicative features in digital factory. Practical coherences of interpersonal communication from a human oriented view were analyzed in Volkswagen AG in Wolfsburg in a pilot project. A modeling method was developed within the process analysis. This method makes it possible to visualize interpersonal communication and its human oriented attribute in a technically focused workflow. Due to the results of a developed inquiry about communication analysis and process models of modeling methods it was possible to build the processes in a suitable way for humans and to obtain a positive implication on the communication processes.

  20. On the Physics Case of a Super Flavour Factory

    SciTech Connect

    Browder, T.; Ciuchini, M.; Gershon, T.; Hazumi, M.; Hurth, T.; Okada, Y.; Stocchi, A.; /Hawaii U. /INFN, Rome /Rome U. /Warwick U. /KEK, Tsukuba /CERN /SLAC /Tsukuba, Graduate U. Adv. Studies /Orsay, LAL /Orsay

    2007-11-07

    We summarize the physics case of a high-luminosity e{sup +}e{sup -} flavor factory collecting an integrated luminosity of 50 - 75 ab{sup -1}. Many New Physics sensitive measurements involving B and D mesons and {tau} leptons, unique to a Super Flavor Factory, can be performed with excellent sensitivity to new particles with masses up to {approx} 100 (or even {approx} 1000) TeV. Flavor- and CP-violating couplings of new particles that may be discovered at the LHC can be measured in most scenarios, even in unfavorable cases assuming minimal flavor violation. Together with the LHC, a Super Flavor Factory, following either the SuperKEKB or the SuperB proposal, could be soon starting the project of reconstructing the New Physics Lagrangian.