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Sample records for 4 6 8

  1. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  2. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  3. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  4. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  5. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  6. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  7. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  8. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  9. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  10. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  11. Genotoxicity tests with 6-acetyl-1,1,2,4,4,7-hexamethyltetraline and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyr an.

    PubMed

    Api, A M; San, R H

    1999-10-29

    6-Acetyl-1,1,2,4,4,7-hexamethyltetraline (AHTN) and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-ben zopyran (HHCB), synthetic fragrance ingredients, were evaluated for potential genotoxicity in a battery of short-term tests. Salmonella typhimurium/Escherichia coli plate incorporation and liquid preincubation assays were conducted on AHTN using tester strains TA97, TA98, TA100, TA102, TA1535, TA1537 and WP2 uvrA +/- S9 activation at doses from 8 to 5000 micrograms/plate. The plate incorporation mutagenicity assay was conducted on HHCB using tester strains TA98, TA100, TA1535, TA1537, TA1538 and WP2 uvrA +/- S9 activation at doses from 10 to 5000 micrograms/plate. An in vitro cytogenetics assay in Chinese hamster ovary (CHO) cells was conducted with AHTN and HHCB at three concentrations each with +/- S9 activation. In the non-activated study, the exposure/harvest periods were 4/20-, 20/20- and 44/44-h. In the S9 activated study, the exposure/harvest periods were 4/20- and 4/44-h. In vitro unscheduled DNA synthesis (UDS) assays were conducted in primary rat hepatocytes at concentrations between 0.15 and 50 micrograms/ml for AHTN and HHCB. In vivo mouse micronucleus assays were conducted with high doses of 1600 mg AHTN/kg and of 1500 mg HHCB/kg in corn oil. No positive responses were observed in any of the tests with HHCB. With AHTN, no positive responses were observed except for cells with structural aberrations in the in vitro cytogenetics assay in CHO cells with S9 activation at the treatment/harvest time of 4/20 h. In initial studies with AHTN, the high dose of 7.8 micrograms/ml showed 0.5% aberrant cells, with the mitotic index at 41% relative to vehicle control and cell growth inhibition in the range of 25-50%. Thus the genotoxicity findings with AHTN were limited to this one positive response; all other genotoxicity tests with AHTN were considered as negative. In particular, the negative finding in the in vivo assay supports AHTN as not likely

  12. The synthesis of 3-hydroxy-2,4,8-trimethyldec-8-enolides and an approach to 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide.

    PubMed

    Botubol-Ares, J M; Durán-Peña, M J; Macías-Sánchez, A J; Hanson, J R; Collado, I G; Hernández-Galán, R

    2015-01-14

    The synthesis of several derivatives of 3-hydroxy-2,4,8-trimethyldec-8-enolide and attempts at the synthesis of 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide (1), a structure which has been assigned to a metabolite of the phytopathogenic fungus, Botrytis cinerea, gave products whose spectroscopic data had significant differences from those reported for the natural product 1. The rare 11-membered lactone rings were constructed by ring-closing metathesis reactions. The increase in conformational restrictions imposed by the substituents has a high influence on the stereochemistry of the ring-closing metathesis reaction and gives rise to a decrease in the yield for the synthesis of 11-membered lactones. The predominant alkene which was obtained was the (Z)-isomer. The observed spectroscopic differences between the synthesized lactones and the natural product and the spectroscopic data of its acetylated derivative 26a allowed us to revise the structure 1 to that of the γ-butyrolactone 26.

  13. Desulfurization of 2,4,6,8-tetraethyl dibenzothiophene by recombinant Mycobacterium sp. strain MR65.

    PubMed

    Watanabe, Kimiko; Noda, Ken-ichi; Konishi, Jin; Maruhashi, Kenji

    2003-09-01

    Recombinant Mycobacterium sp. strain MR65 harboring dszABCD genes was used to desulfurize alkyl dibenzothiophenes (Cx-DBTs) in n-hexadecane. The specific desulfurization activity for 2,4,6,8-tetraethyl DBT (C8-DBT) by DszC enzyme was about twice that for 4,6-dipropyl DBT (C6-DBT). However, the degradation rate of 2,4,6,8-tetraethyl DBT in n-hexadecane by resting cells of strain MR65 was only about 40% of that of 4,6-dipropyl DBT. These results indicated that the desulfurization ability for Cx-DBTs by resting cells depends on carbon number substituted at positions 4 and 6 and that the rate-limiting step in the desulfurization reaction of highly alkylated Cx-DBTs is the transfer process from the oil phase into the cell.

  14. Inhibitory activities against rice pathogens of 8-hydroxy-2,4,6-octatriynamide from Agrocybe sp.

    PubMed

    Zheng, Yongbiao; Xu, Xiaoping; Wu, Yabin

    2016-03-01

    8-Hydroxy-2,4,6-octatriynamide, a natural polyacetylene with inhibitory activities against rice pathogens, was isolated from the liquid fermentation broth of strain Agrocybe sp. YB2005 during screening for new natural chemical agents to control rice pathogens. 8-hydroxy-2,4,6-octatriynamide was purified by consecutive chromatography over a Cl8 reversed phase silica gel, sephadex LH-20 and silica gel. The chemical structure of 8-hydroxy-2,4,6-octatriynamide was elucidated through spectroscopic analyses, including 1D- and 2D-NMR, ESI mass spectrometry and X-ray single crystal diffraction. Bioassays showed that 8-hydroxy-2,4,6-octatriynamide could significantly inhibit growth of Xanthomonas oryzae with an MIC of 53.1 μM in a 96-well plate and the growth of Rhizoctonia solani at 1.02 mM in a 24-well plate. When rice leaves were inoculated with Magnaporthe grisea and cultured in artificial nutrition liquid containing 0.34 mM 8-hydroxy-2,4,6-octatriynamide, no rice blast was observed. The present study implied that 8-hydroxy-2,4,6-octatriynamide could be a candidate agent against rice pathogens. PMID:26861586

  15. 8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition of classification. As a condition of classification and...

  16. 8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition of classification. As a condition of classification and...

  17. 8 CFR 245a.16 - Continuous physical presence from November 6, 1986, through May 4, 1988.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Continuous physical presence from November 6, 1986, through May 4, 1988. 245a.16 Section 245a.16 Aliens and Nationality DEPARTMENT OF HOMELAND... Equity (LIFE) Act Legalization Provisions § 245a.16 Continuous physical presence from November 6,...

  18. 8 CFR 245a.16 - Continuous physical presence from November 6, 1986, through May 4, 1988.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Continuous physical presence from November 6, 1986, through May 4, 1988. 245a.16 Section 245a.16 Aliens and Nationality DEPARTMENT OF HOMELAND... Equity (LIFE) Act Legalization Provisions § 245a.16 Continuous physical presence from November 6,...

  19. 8 CFR 245a.16 - Continuous physical presence from November 6, 1986, through May 4, 1988.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Continuous physical presence from November 6, 1986, through May 4, 1988. 245a.16 Section 245a.16 Aliens and Nationality DEPARTMENT OF HOMELAND... Equity (LIFE) Act Legalization Provisions § 245a.16 Continuous physical presence from November 6,...

  20. 8 CFR 245a.16 - Continuous physical presence from November 6, 1986, through May 4, 1988.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Continuous physical presence from November 6, 1986, through May 4, 1988. 245a.16 Section 245a.16 Aliens and Nationality DEPARTMENT OF HOMELAND... Equity (LIFE) Act Legalization Provisions § 245a.16 Continuous physical presence from November 6,...

  1. 8 CFR 245a.16 - Continuous physical presence from November 6, 1986, through May 4, 1988.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Continuous physical presence from November 6, 1986, through May 4, 1988. 245a.16 Section 245a.16 Aliens and Nationality DEPARTMENT OF HOMELAND... Equity (LIFE) Act Legalization Provisions § 245a.16 Continuous physical presence from November 6,...

  2. 8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition of classification. As a condition of classification and...

  3. Evaluation of the oral subchronic toxicity of HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2 -benzopyran) in the rat.

    PubMed

    Api, A M; Ford, R A

    1999-12-20

    1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-ben zopyran (HHCB) is used in a wide variety of fragrances in consumer products. Because of the widespread exposure to this material, a 90-day oral feeding study in accordance with OECD guidelines No. 408, with 4-week recovery periods for selected rats, was conducted. HHCB was added to the diet of rats at levels calculated to result in mean daily doses of 5, 15, 50 or 150 mg HHCB/kg. On completion of the treatment period, three males and three females from the high dose and control groups were maintained for a treatment free period of 4 weeks. No adverse effects were revealed from clinical examination or following extensive histopathological examinations. There were no significant findings at any dose level; a NOAEL of 150 mg/kg per day was concluded. As a supplement to the main study, histopathological examination of the prostate, seminal vesicles, mammary gland and testes of males and ovaries, mammary gland, uterus and vagina of females was undertaken on all animals in all test groups. This examination did not reveal any evidence of hormonal effects.

  4. Biotransformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) by denitrifying Pseudomonas sp. strain FA1.

    PubMed

    Bhushan, Bharat; Paquet, Louise; Spain, Jim C; Hawari, Jalal

    2003-09-01

    The microbial and enzymatic degradation of a new energetic compound, 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), is not well understood. Fundamental knowledge about the mechanism of microbial degradation of CL-20 is essential to allow the prediction of its fate in the environment. In the present study, a CL-20-degrading denitrifying strain capable of utilizing CL-20 as the sole nitrogen source, Pseudomonas sp. strain FA1, was isolated from a garden soil. Studies with intact cells showed that aerobic conditions were required for bacterial growth and that anaerobic conditions enhanced CL-20 biotransformation. An enzyme(s) involved in the initial biotransformation of CL-20 was shown to be membrane associated and NADH dependent, and its expression was up-regulated about 2.2-fold in CL-20-induced cells. The rates of CL-20 biotransformation by the resting cells and the membrane-enzyme preparation were 3.2 +/- 0.1 nmol h(-1) mg of cell biomass(-1) and 11.5 +/- 0.4 nmol h(-1) mg of protein(-1), respectively, under anaerobic conditions. In the membrane-enzyme-catalyzed reactions, 2.3 nitrite ions (NO(2)(-)), 1.5 molecules of nitrous oxide (N(2)O), and 1.7 molecules of formic acid (HCOOH) were produced per reacted CL-20 molecule. The membrane-enzyme preparation reduced nitrite to nitrous oxide under anaerobic conditions. A comparative study of native enzymes, deflavoenzymes, and a reconstituted enzyme(s) and their subsequent inhibition by diphenyliodonium revealed that biotransformation of CL-20 is catalyzed by a membrane-associated flavoenzyme. The latter catalyzed an oxygen-sensitive one-electron transfer reaction that caused initial N denitration of CL-20. PMID:12957905

  5. Biotransformation of 2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-Hexaazaisowurtzitane (CL-20) by Denitrifying Pseudomonas sp. Strain FA1

    PubMed Central

    Bhushan, Bharat; Paquet, Louise; Spain, Jim C.; Hawari, Jalal

    2003-01-01

    The microbial and enzymatic degradation of a new energetic compound, 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), is not well understood. Fundamental knowledge about the mechanism of microbial degradation of CL-20 is essential to allow the prediction of its fate in the environment. In the present study, a CL-20-degrading denitrifying strain capable of utilizing CL-20 as the sole nitrogen source, Pseudomonas sp. strain FA1, was isolated from a garden soil. Studies with intact cells showed that aerobic conditions were required for bacterial growth and that anaerobic conditions enhanced CL-20 biotransformation. An enzyme(s) involved in the initial biotransformation of CL-20 was shown to be membrane associated and NADH dependent, and its expression was up-regulated about 2.2-fold in CL-20-induced cells. The rates of CL-20 biotransformation by the resting cells and the membrane-enzyme preparation were 3.2 ± 0.1 nmol h−1 mg of cell biomass−1 and 11.5 ± 0.4 nmol h−1 mg of protein−1, respectively, under anaerobic conditions. In the membrane-enzyme-catalyzed reactions, 2.3 nitrite ions (NO2−), 1.5 molecules of nitrous oxide (N2O), and 1.7 molecules of formic acid (HCOOH) were produced per reacted CL-20 molecule. The membrane-enzyme preparation reduced nitrite to nitrous oxide under anaerobic conditions. A comparative study of native enzymes, deflavoenzymes, and a reconstituted enzyme(s) and their subsequent inhibition by diphenyliodonium revealed that biotransformation of CL-20 is catalyzed by a membrane-associated flavoenzyme. The latter catalyzed an oxygen-sensitive one-electron transfer reaction that caused initial N denitration of CL-20. PMID:12957905

  6. The Synthesis of 4,6,8-Trimethylazulene: An Organic Laboratory Experiment.

    ERIC Educational Resources Information Center

    Garst, Michael E.; And Others

    1983-01-01

    A two-stage synthesis of 4,6,8-trimethylazulene was developed for use in the undergraduate experiment, highlighting concepts not usually covered in the laboratory. The experiment requires purification procedures of chromatography and of sublimation and illustrates concepts of aromaticity, molecular orbital theory, and carbodium ion reactivity. (JN)

  7. 8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition... section 101(a)(15)(S) of the Act, nonimmigrants in S classification must have executed Form I-854, Part...

  8. 8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition... section 101(a)(15)(S) of the Act, nonimmigrants in S classification must have executed Form I-854, Part...

  9. 8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition... section 101(a)(15)(S) of the Act, nonimmigrants in S classification must have executed Form I-854, Part...

  10. Nqrs Data for C8H6O4 (Subst. No. 1074)

    NASA Astrophysics Data System (ADS)

    Chihara, H.; Nakamura, N.

    This document is part of Subvolume A `Substances Containing Ag … C10H15' of Volume 48 `Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III `Condensed Matter'. It contains an extract of Section `3.2 Data tables' of the Chapter `3 Nuclear quadrupole resonance data' providing the NQRS data for C8H6O4 (Subst. No. 1074)

  11. A toxicological study of 5,6,7,8 tetrafluoro- 1,4-benzodioxin

    SciTech Connect

    London, J.E.

    1988-05-01

    The acute oral LD/sub 50/ values for 5,6,7,8 tetrafluro-1,4 benzodioxin for mice and rats are less than 5 gkg. According to classical guidelines, the material is considered slightly toxic in both species. The sensitization study in the guinea pig did not show the material to have potential sensitizing properties. Skin application studies on the rabbit demonstrated that it was cutaneously mildly irritating. This material was very mildly irritating in the rabbit eye application studies. 4 refs., 2 tabs.

  12. Dissimilar alloy laser beam welding of titanium: Ti-6Al-4V to Beta-C[trademark]. [Ti-3Al-8V-6Cr-4Mo-4Zr

    SciTech Connect

    Liu, P.S.; Baeslack, W.A. III . Dept. of Welding Engineering); Hurley, J. )

    1994-07-01

    CO[sub 2] laser beam welds were produced between Ti-6Al-4V and Beta-C[trademark] sheet. Three different nominal fusion zone chemical compositions were obtained by varying the laser beam location relative to the joint centerline and thereby melting different quantities of each base metal. Fusion zone microstructures exhibited fine, columnar-shaped beta grains comprised of retained-beta phase and martensite, with the proportion of martensite increasing with an increase in the quantity of Ti-6Al-4V nominally in the fusion zone. The location of these phases within the fusion zone was influenced by macrosegregation, which originated from incomplete mixing of the melted base metals and the occurrence of transverse-solute banding during solidification. Postweld aging heat treatment at 482 C/20 h and 538 C/8 h resulted in extremely fine alpha precipitation within the retained-beta phase regions and tempering of the martensite. These fusion zone microstructures exhibited high hardnesses and strengths superior to those of the Ti-6Al-4V and Beta-C base metals, but low ductility (<2.5%). An increase in the aging temperature to 593 C promoted fusion zone transformation to a coarser intragranular and grain-boundary alpha + beta microstructure, which exhibited a strength superior to those of the base metals and acceptable ductility. Variations in the proportions of Ti-6Al-4V and Beta C within the weld fusion zone generally had a minimal effect on the average hardness and ductility.

  13. [(1,4,8,11-Tetraazacyclotetradeca-1,4,8,11-tetrayl)tetraacetamide-kappa6N1,N4,N8,N11,O1,O8]copper(II) sulfate 4.5-hydrate.

    PubMed

    Espinosa, Enrique; Meyer, Michel; Berard, David; Guilard, Roger

    2002-02-01

    The crystal structure of the title copper(II) complex, [Cu(C(18)H(36)N(8)O(4))]SO(4).4.5H(2)O, formed with the tetraamide cyclam derivative 2-(4,8,11-triscarbamoylmethyl-1,4,8,11-tetraazacyclotetradec-1-yl)acetamide (TETAM), is described. The macrocycle lies on an inversion centre occupied by the hexacoordinated Cu atom. The four macrocyclic tertiary amines form the equatorial plane of an axially Jahn-Teller elongated octahedron. Two O atoms belonging to two diagonally opposite amide groups occupy the apical positions, giving rise to a trans-III stereochemistry, while both the remaining pendant side arms extend outwards from the macrocyclic cavity and are engaged in hydrogen bonds with sulfate anions and co-crystallized water molecules. PMID:11828099

  14. 2,4,6,8-Tetrachlorodibenzothiophene in the Newark Bay Estuary: the likely source and reaction pathways.

    PubMed

    Parette, Robert; Pearson, Wendy N

    2014-09-01

    Historic industrial activity along the Newark Bay Estuary has resulted in pollution from a number of contaminants; one of which is 2,4,6,8-tetrachlorodibenzothiophene (2,4,6,8-TCDT), a unique chemical contaminant whose origins have not been adequately explained. This research demonstrates that the probable source of 2,4,6,8-TCDT was the chlorination of phenol produced via the sulfonation method. Thiophenol, the major impurity in this type of phenol, was likely converted to 2,4,6,8-TCDT through one or more pathways during the production of 2,4-dichlorophenol, 2,4-dichlorophenoxyacetic acid (2,4-D), or 2,4,6-trichlorophenol. From a mass balance standpoint, production of these chemicals at an industrial plant along the Passaic River could account for the 2,4,6,8-TCDT in the Newark Bay Estuary. PMID:24997913

  15. Disposition and excretion of 14C-AHTN (7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) and 14c-hhcb (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran) after intravenous administration to Sprague-Dawley rats and domestic pigs.

    PubMed

    Api, Anne Marie; Ritacco, Gretchen; Sipes, I Glenn

    2013-07-01

    7-Acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene (AHTN ) and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran (HHCB) are polycyclic musks widely used as fragrance ingredients in consumer products. Because their metabolic fate following systemic exposure is not fully characterized, disposition and excretion of (14)C-AHTN- and (14)C-HHCB-derived radioactivity were studied in Sprague-Dawley rats and domestic pigs following a single intravenous dose. Rats administered with AHTN or HHCB excreted 21% or 28% of the radioactivity in urine and 67% or 61% in feces, respectively, within 7 days. In pigs administered AHTN or HHCB, 86% or 74% of the dose was excreted in the urine, and 12% or 15% in feces, respectively, during the 14-day collection period. Radioactivity in the whole blood and plasma of both species and tissues of rats declined steadily until the end of the study (28 days) for both the materials. Radioactivity in rat adipose tissue reached peak at 2 hours after dosing, decreasing steadily thereafter. Radioactivity in pig blood declined rapidly from 70 ng equivalents/g at 10 minutes to 1 ng equivalent/g or less by 28 days after administration of either AHTN or HHCB. Radioactivity in pig skin and adipose tissue decreased to below the limit of detection by 28 days for both the materials. Thin-layer chromatography showed multiple radioactive components in both species' urine after administration of either material. Components found in the urine of the 2 species were qualitatively similar but quantitatively different. Both AHTN and HHCB were completely metabolized and excreted. No unchanged parent compound was detected in rat or pig urine.

  16. Spectral properties of new N, N'-bis-alkyl-1,4,6,8-naphthalenediimide complexes

    NASA Astrophysics Data System (ADS)

    Refat, M. S.; Grabchev, I.; Chovelon, J.-M.; Ivanova, G.

    2006-05-01

    The photophysical properties of two N, N'-bis-alkyl-1,4,6,8-naphthalenediimide (DCN1 and DCN2) have been studied in chloroform and N, N-dimethylformamide solvents. The ability of DCN2 in N, N-dimethylformamide to detect metal cations have been monitored by the fluorescence emission spectroscopy. It has been shown that the fluorescent intensity is very sensitive to the concentration of Fe 3+ cations. The reaction of iodine with N, N'-bis-alkyl-1,4,6,8-naphthalenediimide in chloroform solution have been investigated by spectrophotometric method. The results indicate the formation of two CT-complexes [(DCN1)I] +·I 3- and [(DCN2)I] +·I 3- at donor:acceptor molar ratio of 1:2. The [(DCN1)I] +·I 3- shows the characteristic absorptions of I 3- ion at 290 and 360 nm while the charge-transfer transition of [(DCN2)I] +·I 3- occurs at 310 nm. Three characteristic bands at the far infrared region in each iodine complex are observed around 135, 105 and 85 cm -1 due to νas (I-I), νs (I-I) and δ (I 3-), respectively with C2v symmetry. The values of the complex formation constant, K, and the absorptivity, ɛ have been calculated.

  17. High antiallergic activity of 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone and 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone from eau de cologne mint (Mentha×piperita citrata).

    PubMed

    Sato, Akihiko; Tamura, Hirotoshi

    2015-04-01

    The following compounds with higher antiallergic activities were isolated from eau de cologne mint leaves: 5,6,4'-trihydroxy-7,8-dimethoxyflavone (6), 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone (7), 5,6-dihydroxy-7,3',4'-trimethoxyflavone (8), 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone (9), and 5,6-dihydroxy-7,8,4'-trimethoxyflavone (10). The IC50 values of compounds 6-10 against RBL-2H3 cells were 6.7, 2.4, 5.6, 3.0, and 6.1μM. Compounds 7 and 9 (IC50 2.4μM and 3.0μM) had the highest antiallergic activities among the flavonoids previously reported. The amounts of 7, 9, and 10 isolated were fairly high, at 177.7mg/kg, 278.0mg/kg, and 179.7mg/kg in the mint, respectively. LD5 value (index of toxicity) and LD5/IC50 ratio of 7 and 9 indicate that the safety is greater than that of luteolin, a typical antiallergic substance. The extract containing powerful antiallergic flavones, 6-10 with higher hydrophobicity could be selectively separated from the extract containing luteolin and other flavonoid glycosides by partition with dichloromethane and water. Therefore, compounds 7 and 9 in mint, and the dichloromethane extract would be the most potent and preventive resources against type I allergy.

  18. 8-Hydr-oxy-8-phenyl-2,3,7,8-tetra-hydro-6H-1,4-dioxino[2,3-f]isoindol-6-one.

    PubMed

    Tafeenko, Viktor A; Aslanov, Leonid A; Khasanov, Mahmud I; Mochalov, Sergei S

    2008-01-01

    In the title compound, C(16)H(13)NO(4), the indole system is essentially planar, whereas the dioxane ring adopts a twist conformation. The mol-ecules are linked into chains by -O- H⋯O=C- hydrogen bonds and these chains are linked into rods by means of N-H⋯O hydrogen bonds. Exept for weak C-H⋯O inter-actions between the rods, no other inter-molecular contacts of inter-est are present. PMID:21201891

  19. Genomic characterization of G3P[6], G4P[6] and G4P[8] human rotaviruses from Wuhan, China: Evidence for interspecies transmission and reassortment events.

    PubMed

    Zhou, Xuan; Wang, Yuan-Hong; Ghosh, Souvik; Tang, Wei-Feng; Pang, Bei-Bei; Liu, Man-Qing; Peng, Jin-Song; Zhou, Dun-Jin; Kobayashi, Nobumichi

    2015-07-01

    We report here the whole genomic analyses of two G4P[6] (RVA/Human-wt/CHN/E931/2008/G4P[6], RVA/Human-wt/CHN/R1954/2013/G4P[6]), one G3P[6] (RVA/Human-wt/CHN/R946/2006/G3P[6]) and one G4P[8] (RVA/Human-wt/CHN/E2484/2011/G4P[8]) group A rotavirus (RVA) strains detected in sporadic cases of diarrhea in humans in the city of Wuhan, China. All the four strains displayed a Wa-like genotype constellation. Strains E931 and R1954 shared a G4-P[6]-I1-R1-C1-M1-A8-N1-T1-E1-H1 constellation, whilst the 11 gene segments of strains R946 and E2484 were assigned to G3-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1 and G4-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1 genotypes, respectively. Phylogenetically, the VP7 gene of R946, NSP3 gene of E931, and 10 of 11 gene segments of E2484 (except for VP7 gene) belonged to lineages of human RVAs. On the other hand, based on available data, it was difficult to ascertain porcine or human origin of VP3 genes of strains E931 and R946, and NSP2 genes of strains R946 and R1954. The remaining genes of E2484, E931, R946 and R1954 were close to those of porcine RVAs from China, and/or porcine-like human RVAs. Taken together, our observations suggested that strain R1954 might have been derived from porcine RVAs, whilst strains R946 and E931 might be reassortants possessing human RVA-like gene segments on a porcine RVA genetic backbone. Strain E2484 might be derived from reassortment events involving acquisition of a porcine-like VP7 gene by a Wa-like human RVA strain. The present study provided important insights into zoonotic transmission and complex reassortment events involving human and porcine RVAs, reiterating the significance of whole-genomic analysis of RVA strains. PMID:25891280

  20. Phase transformations in Ti-6.8Mo-4.5Fe-1.5Al

    SciTech Connect

    Azimzadeh, S.; Rack, H.J.

    1998-10-01

    Phase transformations during artificial and isothermal aging of Ti-6.8Mo-4.5Fe-1.5Al have been investigated over the temperature range from 300 C to 750 C utilizing hardness measurements, X-ray diffraction, optical microscopy, and electron microscopy. Artificial aging following solution treatment and water quenching initially involved growth of the athermal {omega} phase. This was followed by formation of the {alpha} phase, either in association with the {omega} phase, through homogeneous precipitation within the matrix, or through heterogeneous grain-boundary nucleation. Similarly, isothermal decomposition of the metastable {beta} phase resulted in the precipitation of {omega} phase exhibiting an ellipsoidal morphology. While precipitation of {omega} was immediate at 345 C, an incubation period was observed upon aging at 390 C. Isothermal aging above this temperature involved direct precipitation of the {alpha} phase, either homogeneously within the {beta} matrix or heterogeneously at {beta} grain boundaries. The extent of homogeneous vs heterogeneous {alpha} nucleation during isothermal aging depended upon aging temperature; low aging temperatures promote homogeneous nucleation and higher aging temperatures promote {alpha} heterogeneous nucleation. Finally, continued aging resulted, independent of aging path, in coarsening and spheroidization of the {alpha} phase.

  1. Proton radii of {sup 4,6,8}He isotopes from high-precision nucleon-nucleon interactions

    SciTech Connect

    Caurier, E.; Navratil, P.

    2006-02-15

    Recently, precision laser spectroscopy on {sup 6}He atoms determined accurately the isotope shift between {sup 4}He and {sup 6}He and, consequently, the charge radius of {sup 6}He. A similar experiment for {sup 8}He is under way. We have performed large-scale ab initio calculations for {sup 4,6,8}He isotopes using high-precision nucleon-nucleon (NN) interactions within the no-core shell model (NCSM) approach. With the CD-Bonn 2000 NN potential we found point-proton root-mean-square (rms) radii of {sup 4}He and {sup 6}He 1.45(1) fm and 1.89(4), respectively, in agreement with experiment and predict the {sup 8}He point-proton rms radius to be 1.88(6) fm. At the same time, our calculations show that the recently developed nonlocal INOY NN potential gives binding energies closer to experiment, but underestimates the charge radii.

  2. Proton Radii of 4,6,8He Isotopes from High-Precision Nucleon-Nucleon Interactions

    SciTech Connect

    Caurier, E; Navratil, P

    2005-11-16

    Recently, precision laser spectroscopy on {sup 6}He atoms determined accurately the isotope shift between {sup 4}He and {sup 6}He and, consequently, the charge radius of {sup 6}He. A similar experiment for {sup 8}He is under way. We have performed large-scale ab initio calculations for {sup 4,6,8}He isotopes using high-precision nucleon-nucleon (NN) interactions within the no-core shell model (NCSM) approach. With the CD-Bonn 2000 NN potential we found point-proton root-mean-square (rms) radii of {sup 4}He and {sup 6}He 1.45(1) fm and 1.89(4), respectively, in agreement with experiment and predict the {sup 8}He point proton rms radius to be 1.88(6) fm. At the same time, our calculations show that the recently developed nonlocal INOY NN potential gives binding energies closer to experiment, but underestimates the charge radii.

  3. Fragrance material review on 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE).

    PubMed

    Scognamiglio, J; Letizia, C S; Politano, V T; Api, A M

    2013-12-01

    A toxicologic and dermatologic review of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE) when used as a fragrance ingredient is presented. OTNE is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for OTNE were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, elicitation, phototoxicity, photoallergy, toxicokinetics, repeated dose, reproductive toxicity, and genotoxicity data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (2013) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances.

  4. The epithelial differentiating activity in vivo of (E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl) -1-propenyl]benzoic acid and 4,4-difluororetinoic acid.

    PubMed Central

    Miller, D A; Stephens-Jarnagin, A; DeLuca, H F

    1985-01-01

    Female rats fed on a vitamin A-deficient diet from weaning were oophorectomized after introitus and used to test analogues of all-trans-retinoic acid for epithelial differentiation activity by the vaginal-smear assay. Several modifications have been made in the assay; housing facilities were modified, the diet changed and the existing scoring system for the assay altered. The arotinoid (E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl)-1 -propenyl] benzoic acid was 12-fold more active than all-trans-retinoic acid, which had a 50% effective dose (ED50) of 80 pmol/vagina. The fluorinated analogue 4,4-difluororetinoic acid had an ED50 of 2.5 nmol/vagina and was therefore 30-fold less active than all-trans-retinoic acid. PMID:3994687

  5. Hardware Design and Implementation of Fixed-Width Standard and Truncated 4×4, 6×6, 8×8 and 12×12-BIT Multipliers Using Fpga

    NASA Astrophysics Data System (ADS)

    Rais, Muhammad H.

    2010-06-01

    This paper presents Field Programmable Gate Array (FPGA) implementation of standard and truncated multipliers using Very High Speed Integrated Circuit Hardware Description Language (VHDL). Truncated multiplier is a good candidate for digital signal processing (DSP) applications such as finite impulse response (FIR) and discrete cosine transform (DCT). Remarkable reduction in FPGA resources, delay, and power can be achieved using truncated multipliers instead of standard parallel multipliers when the full precision of the standard multiplier is not required. The truncated multipliers show significant improvement as compared to standard multipliers. Results show that the anomaly in Spartan-3 AN average connection and maximum pin delay have been efficiently reduced in Virtex-4 device.

  6. Rietveld refinement and ionic conductivity of Ca{sub 8.4}Bi{sub 1.6}(PO{sub 4}){sub 6}O{sub 1.8}

    SciTech Connect

    Tmar Trabelsi, I.; Madani, A.; Mercier, A.M.; Toumi, M.

    2013-01-15

    The structure of Ca{sub 8.4}Bi{sub 1.6}(PO{sub 4}){sub 6}O{sub 1.8}, isostructural with Fluoroapatite, was determined by X-ray powder diffraction methods. The results of Rietveld refinement revealed that the formula of this compound is [Ca{sub 4}]{sup 4f}[Ca{sub 4.4}Bi{sub 1.6}]{sup 6h}(PO{sub 4}){sub 6}[O{sub 1.8}]{sup 2a}, space group P63/m (a=9.468 (3) A, c=6.957 (3) A). A total substitution of Bi{sup 3+} ions in the (6h) sites was related particularly to the high polarizability of the Bi{sup 3+} ion compared to Ca{sup 2+}. The observed frequencies in the Raman and infrared spectra were explained and discussed on the basis of unit-cell group analyses and in comparison with Fluoroapatite and other oxyapatites. The ionic conductivity over a wide range of temperature was investigated according to the complex impedance method. The highest overall conductivity values were found at {sigma}{sub 700 Degree-Sign C} =5.03 Multiplication-Sign 10{sup -7} S cm{sup -1} and E{sub a}=0.50 eV. - Graphical abstract: The final Rietveld refinement plot of the Ca{sub 8.4}Bi{sub 1.6} (PO{sub 4}){sub 6}O{sub 1.8}. Highlights: Black-Right-Pointing-Pointer The Rietveld refinement revealed that the formula of this compound is Ca{sub 8.4}Bi{sub 1.6}(PO{sub 4}){sub 6}O{sub 1.8}. Black-Right-Pointing-Pointer Vibrational spectroscopy supports the high symmetry P63/m space group for this apatite. Black-Right-Pointing-Pointer This apatite contained channels where oxygen ions were located in 2a sites. Black-Right-Pointing-Pointer The possibility of anionic conduction along these channels was considered.

  7. Mesostructured material based on [Re6Te8(CN)6]4- cluster and Mn(2+): a rational synthesis of hexagonal nonoxidic mesoscale material.

    PubMed

    Vien, Vo; Suh, Min-Jung; Huh, Seong; Kim, Youngmee; Kim, Sung-Jin

    2009-02-01

    A new nonoxidic mesostructured material with highly ordered hexagonal symmetry, [C(16)H(33)N(CH(3))(3)](3)Mn(0.5)[Re(6)Te(8)(CN)(6)], has been obtained through supramolecular assembly of [Re(6)Te(8)(CN)(6)](4-) clusters in the presence of a transition metal cation, Mn(2+), with cetyltrimethylammonium bromide as a liquid crystal template under hydrothermal conditions.

  8. Mesostructured material based on [Re6Te8(CN)6]4- cluster and Mn(2+): a rational synthesis of hexagonal nonoxidic mesoscale material.

    PubMed

    Vien, Vo; Suh, Min-Jung; Huh, Seong; Kim, Youngmee; Kim, Sung-Jin

    2009-02-01

    A new nonoxidic mesostructured material with highly ordered hexagonal symmetry, [C(16)H(33)N(CH(3))(3)](3)Mn(0.5)[Re(6)Te(8)(CN)(6)], has been obtained through supramolecular assembly of [Re(6)Te(8)(CN)(6)](4-) clusters in the presence of a transition metal cation, Mn(2+), with cetyltrimethylammonium bromide as a liquid crystal template under hydrothermal conditions. PMID:19283284

  9. Analysis of p-4,6,8He and p-6,8,9,11Li scattering at 700 MeV

    NASA Astrophysics Data System (ADS)

    Chauhan, Deeksha; Khan, Z. A.; Usmani, A. A.

    2015-02-01

    The Glauber model is used to analyze the elastic scattering of protons from He and Li isotopes at ˜700 MeV. The calculations require two inputs; the nucleon-nucleon (NN) amplitude and the nucleon density distributions for the target nuclei. The NN amplitude is taken from the available NN scattering data, and, for the target nuclei, we use some of the nucleon density distributions available in the literature. The emphasis, in this work, is to study the sensitivity of the calculated differential cross sections for p-4,6,8He scattering on the density distributions used, and to compare the results with some recent findings in view of assessing the suitability of nucleon density distributions for a given nucleus at relatively low and intermediate energies. The results demonstrate that the study of p-nucleus scattering could be helpful in providing useful information about the behavior of matter density distribution in the surface and interior regions of a nuclear medium. Further, we find that the phase of the NN amplitude plays a role in providing a better description of the experimental data in all the cases.

  10. Process for manufacturing bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene

    DOEpatents

    Rasmussen, Paul George; Lawton, Richard Graham

    2014-06-03

    A process to manufacture substituted tetracyano-hexaazatricyclics with the substitutions occurring at the 9 and 10 hydrogens. The process begins with 2,3-dichloro-5,6-dicyanopyrazine, which is reacted to form the desired tetracyano-hexaazatricyclic. Different process embodiments enable different reaction paths to the desired tetracyano-hexaazatricyclic. Different tetracyano-hexaazatricyclic embodiments include bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene and bis(2-methoxyethoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracen- e.

  11. Bis[5-oxo-4,5-dihydro-8H-2-azonia-4,8,9-trizabicyclo[4.3.0]nona-2,6,9(1)-triene] sulfate.

    PubMed

    Ravindra, Nittala V; Panpalia, Gopal M; Sarma, Jagarlapudi A R P

    2008-11-22

    In the crystal structure of the title compound, 2C(5)H(5)N(4)O(+)·SO(4) (2-), N-H⋯O hydrogen bonds assemble the mol-ecules into a two-dimensional network structure parallel to the cb plane. The S atom of the sulfate ion lies on a special position on a twofold axis.

  12. Crystal structure of a prokaryotic (6-4) photolyase with an Fe-S cluster and a 6,7-dimethyl-8-ribityllumazine antenna chromophore.

    PubMed

    Zhang, Fan; Scheerer, Patrick; Oberpichler, Inga; Lamparter, Tilman; Krauß, Norbert

    2013-04-30

    The (6-4) photolyases use blue light to reverse UV-induced (6-4) photoproducts in DNA. This (6-4) photorepair was thought to be restricted to eukaryotes. Here we report a prokaryotic (6-4) photolyase, PhrB from Agrobacterium tumefaciens, and propose that (6-4) photolyases are broadly distributed in prokaryotes. The crystal structure of photolyase related protein B (PhrB) at 1.45 Å resolution suggests a DNA binding mode different from that of the eukaryotic counterparts. A His-His-X-X-Arg motif is located within the proposed DNA lesion contact site of PhrB. This motif is structurally conserved in eukaryotic (6-4) photolyases for which the second His is essential for the (6-4) photolyase function. The PhrB structure contains 6,7-dimethyl-8-ribityllumazine as an antenna chromophore and a [4Fe-4S] cluster bound to the catalytic domain. A significant part of the Fe-S fold strikingly resembles that of the large subunit of eukaryotic and archaeal primases, suggesting that the PhrB-like photolyases branched at the base of the evolution of the cryptochrome/photolyase family. Our study presents a unique prokaryotic (6-4) photolyase and proposes that the prokaryotic (6-4) photolyases are the ancestors of the cryptochrome/photolyase family.

  13. Binding Patterns of Rotavirus Genotypes P[4], P[6], and P[8] in China with Histo-Blood Group Antigens.

    PubMed

    Ma, Xin; Li, Dan-di; Sun, Xiao-Man; Guo, Yan-Qing; Xiang, Jing-Yao; Wang, Wei-Huan; Zhang, Li-Xia; Gu, Qing-Jiu; Duan, Zhao-Jun

    2015-01-01

    Rotaviruses (RVs) are an important cause of severe gastroenteritis in children. It has been found that RV may recognize the histo-blood group antigens (HBGAs) as ligands or receptors and bind HBGAs in a type-dependent manner. In this study, we investigated the binding specificity of VP8* proteins from human rotaviruses (RV) that are prevalent in China including genotypes P[4], P[6], and P[8]. Through the saliva- and oligosaccharide-based binding assays, we found that the VP8* proteins of P[4] and P[8] RV showed similar reactivity with the Leb and H type 1 antigens, while P[6] RV weakly bound the Leb antigen. These findings may facilitate further research into RV host specificity and vaccine development. PMID:26274396

  14. Binding Patterns of Rotavirus Genotypes P[4], P[6], and P[8] in China with Histo-Blood Group Antigens

    PubMed Central

    Ma, Xin; Li, Dan-di; Sun, Xiao-man; Guo, Yan-qing; Xiang, Jing-yao; Wang, Wei-huan; Zhang, Li-xia; Gu, Qing-jiu; Duan, Zhao-jun

    2015-01-01

    Rotaviruses (RVs) are an important cause of severe gastroenteritis in children. It has been found that RV may recognize the histo-blood group antigens (HBGAs) as ligands or receptors and bind HBGAs in a type-dependent manner. In this study, we investigated the binding specificity of VP8* proteins from human rotaviruses (RV) that are prevalent in China including genotypes P[4], P[6], and P[8]. Through the saliva- and oligosaccharide-based binding assays, we found that the VP8* proteins of P[4] and P[8] RV showed similar reactivity with the Leb and H type 1 antigens, while P[6] RV weakly bound the Leb antigen. These findings may facilitate further research into RV host specificity and vaccine development. PMID:26274396

  15. Pioneer 6 through 8

    NASA Technical Reports Server (NTRS)

    Lozier, D.; Fimmel, R.

    1991-01-01

    The DSN (Deep Space Network) mission support requirements for Pioneer 6, 7 and 8 are summarized. The primary objective of these Pioneer missions is to collect scientific data relative to interplanetary phenomena within a range of approximately 0.8 to 1.2 astronomical units from the sun. Following orbital injection, each spacecraft was oriented with its spin axis normal to the ecliptic plane so that the high gain antenna pattern would be aligned with Earth's orbit. The mission objectives are outlined and the DSN support requirements are defined through the presentation of tables and narratives describing the spacecraft flight profiles; DSN support coverage; frequency assignments; support parameters for telemetry, command and support systems; and tracking support responsibility.

  16. Do Children See the "Danger" in "Dangerous"? Grade 4, 6, and 8 Children's Reading of Morphologically Complex Words

    ERIC Educational Resources Information Center

    Deacon, S. Helene; Whalen, Rachel; Kirby, John R.

    2011-01-01

    We examined whether Grade 4, 6, and 8 children access the base form when reading morphologically complex words. We asked children to read words varying systematically in the frequency of the surface and base forms and in the transparency of the base form. At all grade levels, children were faster at reading derived words with high rather than low…

  17. Nqrs Data for C8H9KO6 [C8H5KO4·2(H2O)] (Subst. No. 1092)

    NASA Astrophysics Data System (ADS)

    Chihara, H.; Nakamura, N.

    This document is part of Subvolume A `Substances Containing Ag … C10H15' of Volume 48 `Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III `Condensed Matter'. It contains an extract of Section `3.2 Data tables' of the Chapter `3 Nuclear quadrupole resonance data' providing the NQRS data for C8H9KO6 [C8H5KO4·2(H2O)] (Subst. No. 1092)

  18. Cluster Chemistry in Electron-Poor Ae-Pt-Cd Systems (Ae=Ca, Sr, Ba): (Sr,Ba)Pt2Cd4, Ca6Pt8Cd16, and Its Known Antitype Er6Pd16Sb8

    SciTech Connect

    Samal, Saroj L.; Gulo, Fakhili; Corbett, John D.

    2013-02-18

    Three new ternary polar intermetallic compounds, cubic Ca6Pt8Cd16, and tetragonal (Sr, Ba)Pt2Cd4 have been discovered during explorations of the Ae–Pt–Cd systems. Cubic Ca6Pt8Cd16 (Fm-3m, Z = 4, a = 13.513(1) Å) contains a 3D array of separate Cd8 tetrahedral stars (TS) that are both face capped along the axes and diagonally bridged by Pt atoms to generate the 3D anionic network Cd8[Pt(1)]6/2[Pt(2)]4/8. The complementary cationic surface of the cell consists of a face-centered cube of Pt(3)@Ca6 octahedra. This structure is an ordered ternary variant of Sc11Ir4 (Sc6Ir8Sc16), a stuffed version of the close relative Na6Au7Cd16, and a network inverse of the recent Er6Sb8Pd16 (compare Ca6Pt8Cd16). The three groups of elements each occur in only one structural version. The new AePt2Cd4, Ae = Sr, Ba, are tetragonal (P42/mnm,Z = 2, a ≈ 8.30 Å, c ≈ 4.47 Å) and contain chains of edge-sharing Cd4 tetrahedra along c that are bridged by four-bonded Ba/Sr. LMTO-ASA and ICOHP calculation results and comparisons show that the major bonding (Hamilton) populations in Ca6Pt8Cd16 and Er6Sb8Pd16 come from polar Pt–Cd and Pd–Sb interactions, that Pt exhibits larger relativistic contributions than Pd, that characteristic size and orbital differences are most evident for Sb 5s, Pt8, and Pd16, and that some terms remain incomparable, Ca–Cd versus Er–Pd.

  19. Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) on a soil organic matter. A DFT M05 computational study.

    PubMed

    Sviatenko, Liudmyla K; Gorb, Leonid; Shukla, Manoj K; Seiter, Jennifer M; Leszczynska, Danuta; Leszczynski, Jerzy

    2016-04-01

    Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) by soil organic matter considering the Leonardite Humic Acid (LHA) model at the M05/tzvp level of Density Functional Theory (DFT) applying cluster approximation has been investigated. Different orientations of CL-20 toward LHA surface were examined. It was found that deprotonation of LHA is required to obtain stable complexes with CL-20. Hydrogen bonds between CL-20 and deprotonated LHA were analyzed applying the atoms in molecules (AIM) theory. An attachment or removal of an electron with respect to the complex does not have significant effect on mutual orientation of the adsorbent in complexes. It was shown that adsorbed CL-20 does not undergo redox transformation and, therefore, adsorption on soil organic matter may be responsible for decrease of the degradation rate of CL-20 in soil.

  20. Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) on a soil organic matter. A DFT M05 computational study.

    PubMed

    Sviatenko, Liudmyla K; Gorb, Leonid; Shukla, Manoj K; Seiter, Jennifer M; Leszczynska, Danuta; Leszczynski, Jerzy

    2016-04-01

    Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) by soil organic matter considering the Leonardite Humic Acid (LHA) model at the M05/tzvp level of Density Functional Theory (DFT) applying cluster approximation has been investigated. Different orientations of CL-20 toward LHA surface were examined. It was found that deprotonation of LHA is required to obtain stable complexes with CL-20. Hydrogen bonds between CL-20 and deprotonated LHA were analyzed applying the atoms in molecules (AIM) theory. An attachment or removal of an electron with respect to the complex does not have significant effect on mutual orientation of the adsorbent in complexes. It was shown that adsorbed CL-20 does not undergo redox transformation and, therefore, adsorption on soil organic matter may be responsible for decrease of the degradation rate of CL-20 in soil. PMID:26814703

  1. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H{sub 2} hydrogenation reaction network.

  2. 3,3,6,6,9,9-Hexaethyl-1,2,4,5,7,8-hexaoxacyclononane at 296 K.

    PubMed

    Cerna, Jorge; Bernès, Sylvain; Cañizo, Adriana; Eyler, Nora

    2009-11-01

    The title molecule (diethyl ketone triperoxide, DEKTP), C(15)H(30)O(6), is a cyclic triperoxide closely related to triacetone triperoxide (TATP), one of the most unstable explosives known. However, the stability of DEKTP is ca 20-50 times greater than that of TATP. DEKTP crystallizes with two molecules in the asymmetric unit, with virtually identical geometry. The cyclononane core is stabilized in a twisted boat-chair conformation (approximate D(3) symmetry), very close to that previously described for TATP. The explanation for the safe thermal behaviour of DEKTP compared with TATP should thus not be sought in the molecular dimensions, but rather in the thermal decomposition kinetics. PMID:19893236

  3. Organocatalyzed enantioselective synthesis of 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylates

    PubMed Central

    Ramireddy, Naresh; Abbaraju, Santhi; Zhao, Cong-Gui

    2011-01-01

    The organocatalyzed enantioselective synthesis of biologically active 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate derivatives was achieved using bifunctional cinchona alkaloids as the catalysts. Using quinine thiourea as the catalyst, the tandem Michael addition-cyclization reaction between 1,3-cyclohexanediones and alkylidenecyanoacetate derivatives gives the desired products in high yields (up to 92%) and good ee values (up to 82%). PMID:22081731

  4. Racemic tricarbonyl[(4a,5,6,7,8,8a-η)-2-phenyl-3,4-dihydro-2H-1-benzopyran]chromium(0)

    PubMed Central

    van Tonder, Johannes H.; Bezuidenhoudt, Barend C. B.; Janse van Rensburg, J. Marthinus

    2010-01-01

    The title compound, [Cr(C15H14O)(CO)3], displays a distorted envelope configuration of the dihydro­pyrane ring. The dihedral angle between the phenyl and phenyl­ene rings is 50.63 (4)°. The Cr0 atom is coordinated by three CO groups and the phenyl­ene ring of the flavan ligand in an η6 mode, with a common arene-to-metal distance PMID:21588503

  5. The crystal structure and morphology of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) p-xylene solvate: a joint experimental and simulation study.

    PubMed

    Shen, Fanfan; Lv, Penghao; Sun, Chenghui; Zhang, Rubo; Pang, Siping

    2014-01-01

    The crystal structure of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaiso-wurtzitane (CL-20) p-xylene solvate, and the solvent effects on the crystal faces of CL-20 were studied through a combined experimental and theoretical method. The properties were analyzed by thermogravimetry-differential scanning calorimetry (TG-DSC), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD).The growth morphology of CL-20p-xylene solvate crystal was predicted with a modified attachment energy model. The crystal structure of CL-20p-xylene solvate belonged to the Pbca space group with the unit cell parameters, a=8.0704(12) Å, b=13.4095(20) Å, c=33.0817(49) Å, and Z=4, which indicated that the p-xylene solvent molecules could enter the crystal lattice of CL-20 and thus the CL-20 p-xylene solvate is formed. According to the solvent-effected attachment energy calculations, (002) and (11-1) faces should not be visible at all, while the percentage area of the (011) face could be increased from 7.81% in vacuum to 12.51% in p-xylene solution. The predicted results from the modified attachment energy model agreed very well with the observed morphology of crystals grown from p-xylene solution. PMID:25401400

  6. Molecular structure and protonation trends in 6-methoxy- and 8-methoxy-2,4,5-tris(dimethylamino)quinolines

    NASA Astrophysics Data System (ADS)

    Dyablo, O. V.; Pozharskii, A. F.; Shmoilova, E. A.; Ozeryanskii, V. A.; Fedik, N. S.; Suponitsky, K. Yu.

    2016-03-01

    Molecular structure and protonation trends of 6-methoxy- 7 and 8-methoxy- 8 derivatives of 2,4,5-tris(dimethylamino)quinoline were studied using X-ray measurements, NMR spectra and theoretical calculations. It has been found that while 8 in the solid state forms protic salts of a quinolinium type, its isomer 7 behaves as a typical proton sponge giving the anilinium cation with a proton chelated by peri-NMe2 groups. In solution, both compounds are simultaneously monoprotonated at two possible centers but again a tendency of 7 to form anilinium cation is much higher if compared to 8. It has been also shown that basicity of 7 is the largest among all known derivatives of 4,5-bis(dimethylamino)quinoline and even slightly exceeds that of 1,8-bis(dimethylamino)naphthalene (parent proton sponge). This was attributed to the "buttressing effect" exhibited by the 6-MeO group. Stable double salts of 7 with picrate and perchlorate anions unprecedented for azines with conjugated aza and NMe2 groups were obtained and thoroughly studied.

  7. Silicon etch using SF{sub 6}/C{sub 4}F{sub 8}/Ar gas mixtures

    SciTech Connect

    Bates, Robert L.; Stephan Thamban, P. L.; Goeckner, Matthew J.; Overzet, Lawrence J.

    2014-07-01

    While plasmas using mixtures of SF{sub 6}, C{sub 4}F{sub 8}, and Ar are widely used in deep silicon etching, very few studies have linked the discharge parameters to etching results. The authors form such linkages in this report. The authors measured the optical emission intensities of lines from Ar, F, S, SF{sub x}, CF{sub 2}, C{sub 2}, C{sub 3}, and CS as a function of the percentage C{sub 4}F{sub 8} in the gas flow, the total gas flow rate, and the bias power. In addition, the ion current density and electron temperature were measured using a floating Langmuir probe. For comparison, trenches were etched of various widths and the trench profiles (etch depth, undercut) were measured. The addition of C{sub 4}F{sub 8} to an SF{sub 6}/Ar plasma acts to reduce the availability of F as well as increase the deposition of passivation film. Sulfur combines with carbon in the plasma efficiently to create a large optical emission of CS and suppress optical emissions from C{sub 2} and C{sub 3}. At low fractional flows of C{sub 4}F{sub 8}, the etch process appears to be controlled by the ion flux more so than by the F density. At large C{sub 4}F{sub 8} fractional flows, the etch process appears to be controlled more by the F density than by the ion flux or deposition rate of passivation film. CF{sub 2} and C{sub 2} do not appear to cause deposition from the plasma, but CS and other carbon containing molecules as well as ions do.

  8. One-step catalytic asymmetric synthesis of all-syn deoxypropionate motif from propylene: Total synthesis of (2R,4R,6R,8R)-2,4,6,8-tetramethyldecanoic acid

    PubMed Central

    Ota, Yusuke; Murayama, Toshiki; Nozaki, Kyoko

    2016-01-01

    In nature, many complex structures are assembled from simple molecules by a series of tailored enzyme-catalyzed reactions. One representative example is the deoxypropionate motif, an alternately methylated alkyl chain containing multiple stereogenic centers, which is biosynthesized by a series of enzymatic reactions from simple building blocks. In organic synthesis, however, the majority of the reported routes require the syntheses of complex building blocks. Furthermore, multistep reactions with individual purifications are required at each elongation. Here we show the construction of the deoxypropionate structure from propylene in a single step to achieve a three-step synthesis of (2R,4R,6R,8R)-2,4,6,8-tetramethyldecanoic acid, a major acid component of a preen-gland wax of the graylag goose. To realize this strategy, we focused on the coordinative chain transfer polymerization and optimized the reaction condition to afford a stereo-controlled oligomer, which is contrastive to the other synthetic strategies developed to date that require 3–6 steps per unit, with unavoidable byproduct generation. Furthermore, multiple oligomers with different number of deoxypropionate units were isolated from one batch, showing application to the construction of library. Our strategy opens the door for facile synthetic routes toward other natural products that share the deoxypropionate motif. PMID:26908873

  9. Design of Mach-4 and Mach-6 Nozzles for the NASA LaRC 8-Ft High Temperature Tunnel

    NASA Technical Reports Server (NTRS)

    Gaffney, Richard L., Jr.

    2009-01-01

    The aerodynamic contours for two new nozzles have been designed for the NASA Langley Research Center 8-Foot High Temperature Tunnel. The new Mach-4 and Mach-6 contours have 54.5-inch exit-diameters allowing for testing at high dynamic pressures. The Mach-4 nozzle will extend the test capability of the facility and allow turbine-based combined-cycle propulsion systems to be tested at conditions appropriate for the transition from the turbine to the scramjet flowpath. The Mach-6 nozzle will serve a dual purpose; to provide a Mach-6 test capability at high dynamic pressure and to be used in conjunction with an existing mixer section for testing at lower enthalpy conditions. This second use will extend the life of the existing Mach-7 nozzle which has been used for this purpose. The two new nozzles, in conjunction with existing nozzles, will allow for testing at Mach numbers of 3, 4, 5 and 6 at high dynamic pressures, and Mach 4, 5 and 7 at lower dynamic pressures but larger scales.

  10. Selective detection of 2,4,6-trinitrophenol based on a fluorescent nanoscale bis(8-hydroxyquinoline) metal complex.

    PubMed

    Lv, Xiao-Jun; Qi, Liang; Gao, Xiang-Yu; Wang, Huan; Huo, Yuan; Zhang, Zhi-Qi

    2016-04-01

    The reliable and accurate detection of explosives such as 2,4,6-trinitrophenol (TNP) and 2,4,6-trinitrotoluene (TNT) is in high demand for homeland security and public safety. Although extremely high sensitivity towards TNT has been demonstrated, detection of TNP remains a challenge. In this work, a fluorescent nanoscale complex composed of bis(8-hydroxyquinoline) and Al(3+) ions has been prepared, characterized and applied in detection of TNP. This complex exhibits the ability to sense the nitro explosive TNP via a fluorescence quenching mechanism with high selectivity. A simple paper test system for the rapid monitoring of TNP was also investigated. The results show that Bhq-Al is a quite ideal sensing material for trace-level detection of TNP. PMID:26838414

  11. A family of octahedral rhenium cluster complexes [Re6Q8(H2O)n(OH)6-n]n-4 (Q=S, Se; n=0-6): structural and pH-dependent spectroscopic studies.

    PubMed

    Brylev, Konstantin A; Mironov, Yuri V; Yarovoi, Spartak S; Naumov, Nikolai G; Fedorov, Vladimir E; Kim, Sung-Jin; Kitamura, Noboru; Kuwahara, Yusuke; Yamada, Konatsu; Ishizaka, Shoji; Sasaki, Yoichi

    2007-09-01

    The conversions of hexahydroxo rhenium cluster complexes [Re6Q8(OH)6]4- (Q=S, Se) in aqueous solutions in a wide pH range were investigated by chemical methods and spectroscopic measurements. Dependences of the spectroscopic and excited-state properties of the solutions on pH have been studied in detail. It has been found that a pH decrease of aqueous solutions of the potassium salts K4[Re6Q8(OH)6].8H2O (Q=S, Se) results in the formation of aquahydroxo and hexaaqua cluster complexes with the general formula [Re6Q8(H2O)n(OH)6-n]n-4 that could be considered as a result of the protonation of the terminal OH- ligands in the hexahydroxo complexes. The compounds K2[Re6S8(H2O)2(OH)4].2H2O (1), [Re6S8(H2O)4(OH)2].12H2O (2), [Re6S8(H2O)6][Re6S6Br8].10H2O (3), and [Re6Se8(H2O)4(OH)2] (4) have been isolated and characterized by X-ray single-crystal diffraction and elemental analyses and infrared (IR) spectroscopy. In crystal structures of the aquahydroxo complexes, the cluster units are connected to each other by an extensive system of very strong hydrogen bonds between terminal ligands. PMID:17676730

  12. Anticonvulsant Profiles of Certain New 6-Aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-Aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones

    PubMed Central

    Aboul-Enein, Mohamed N.; El-Azzouny, Aida A.; Attia, Mohamed I.; Maklad, Yousreya A.; Aboutabl, Mona E.; Ragab, Fatma; El-Hamid, Walaa H. A. Abd

    2014-01-01

    Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a–l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones (6m–x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino]cycloalkanecarboxamides (3a–f) were prepared via adopting Strecker synthesis on the proper cycloalkanone followed by partial hydrolysis of the obtained nitrile functionality and subsequent N-cyanomethylation. Compounds 3a–f were subjected to complete nitrile hydrolysis to give the respective carboxylic acid derivatives 4a–f which were cyclized under mild conditions to give the spiro compounds 5a–f. Ultimately, compounds 5a–f were alkylated or aralkylated to give the target compounds 6a–i and 6m–u. On the other hand, compounds 6j–l and 6v–x were synthesized from the intermediates 5a–f through alkylation, dehydration and finally tetrazole ring formation. Anticonvulsant screening of the target compounds 6a–x revealed that compound 6g showed an ED50 of 0.0043 mmol/kg in the scPTZ screen, being about 14 and 214 fold more potent than the reference drugs, Phenobarbital (ED50 = 0.06 mmol/kg) and Ethosuximide (ED50 = 0.92 mmol/kg), respectively. Compound 6e exhibited an ED50 of 0.019 mmol/kg, being about 1.8 fold more potent than that of the reference drug, Diphenylhydantoin (ED50 = 0.034 mmol/kg) in the MES screen. Interestingly, all the test compounds 6a–x did not show any minimal motor impairment at the maximum administered dose in the neurotoxicity screen. PMID:25250910

  13. Computational study of Cs immobilization in the apatites Ca10(PO4)6F2, Ca4La6(SiO4)6F2 and Ca2La8(SiO4)6O2

    NASA Astrophysics Data System (ADS)

    Chartier, Alain; Meis, Constantin; Gale, Julian D.

    2001-08-01

    Incorporation and lattice migration of cesium in three apatites fluorapatite Ca10(PO4)6F2, lanthanum-fluorobritholite Ca4La6(SiO4)6F2 and lanthanum-oxyapatite Ca2La8(SiO4)6O2 have been studied theoretically. The above apatites have been first optimized by applying the ab initio Hartree-Fock method using electron core pseudopotentials. Mulliken analysis has shown the calculated anion charges in the apatite tunnels to have formal values, thus establishing the presence of ionic bonds with cations at site II (6h), particularly in Ca2La8(SiO4)6O2. These results have been used for optimizing the corresponding interactions in the interatomic potential method employed in the following. Free energy calculations have shown the preferential site for Cs and La incorporation in the three apatites to be site I (4f) and site II (6h), respectively. The calculated activation energies for Cs migration offer evidence that cesium diffusion is mainly controlled by intersite (I<-->II) jumps to adjacent vacancies. Ca2La8(SiO4)6O2 proves to have the higher immobilization capacity, because of the high activation energies characterizing all the possible lattice diffusion mechanisms.

  14. Isomorphous Substitution of Rare-Earth Elements in Lacunary Apatite Pb8Na2(PO4)6.

    PubMed

    Get'man, Evgeni I; Loboda, Stanislav N; Ignatov, Alexey V; Prisedsky, Vadim V; Abdul Jabar, Mohammed A B; Ardanova, Lyudmyla I

    2016-03-01

    The substitution of rare-earth elements (REEs) for Pb in the lacunary apatite Pb8Na2(PO4)6 with void structural channels was studied by means of powder X-ray diffraction (including the Rietveld refinement), scanning electron microscopy, energy-dispersive X-ray microanalysis, and IR spectroscopy and also measurements of the electrical conductivity. The substitution limits (xmax in Pb8-xLnxNa2(PO4)6Ox/2) at 800 °C were found to decrease with the atomic number of the REE from 1.40 for La to 0.12 for Yb with a rapid drop from light to heavy lanthanides (between Gd and Tb). The REE atoms substitute for Pb predominantly at Pb2 sites of the apatite structure according to the scheme 2Pb(2+) + □ → 2Ln(3+) + O(2-), where □ is a vacancy in the structural channel. The substitution in lacunary apatite produces quite different changes in the structural parameters compared with broadly studied alkaline-earth hydroxyapatites. In spite of the much lower ionic radii of REE than that of Pb(2+), the mean distances ⟨Pb1-O⟩ somewhat increase, whereas the distances ⟨Pb2-Pb2⟩ and ⟨Pb2-O4⟩ do not change considerably with the degree of substitution. This implies control of the substitution by not only spatial and charge accommodation of REE ions but also the availability of a stereochemically active 6s(2) electron pair on Pb(2+). The high-temperature electrical conductivity shows dependence on the degree of substitution with a minimum at x = 0.2 indicative of a possible change of the type of conductivity.

  15. Aerobic biodegradation of toluene-2,4-di(8:2 fluorotelomer urethane) and hexamethylene-1,6-di(8:2 fluorotelomer urethane) monomers in soils.

    PubMed

    Dasu, Kavitha; Lee, Linda S

    2016-02-01

    Aerobic soil biodegradation of toluene-2,4-di(8:2 fluorotelomer urethane) (FTU) and hexamethylene-1,6-di(8:2 fluorotelomer urethane) (HMU) in a forest soil and FTU in an agricultural silty clay loam soil was monitored for up to 6 months. Fluorotelomer alcohols were measured in headspace and parent monomers and all metabolites in soil extracts. Negligible degradation of FTU biodegradation occurred in the agricultural soil with 94 ± 15% recovered at day 180. However, in the forest soil, both FTU and HMU degradation was evident with significant losses of 24% (117 d) and 27% (180 day), respectively, and concomitant increases in the terminal metabolite, perfluorooctanoic acid (PFOA) concentrations were well above what could result from residual 8:2 FTOH. Kinetic modeling estimated half-lives for FTU (aromatic backbone) and HMU (aliphatic backbone) in the forest soil to be 3-5 months and 15.9-22.2 months, respectively. The addition of a structurally similar non-fluorinated FTU analog, toluene-2,4-dicarbamic acid diethyl ester (TDAEE) enhanced production of terminal end products from 8:2 FTOH degradation. However, there was no clear evidence that TDAEE enhanced cleavage of the urethane bond, thus TDAEE appeared to just serve as an additional carbon source. TDAEE's half-life was ∼ one week. A second addition of TDAEE appeared to retard subsequent degradation of FTU exemplifying the microbial dynamics and diversity impacting degradation of polyfluoroalkyl substances. Enhanced degradation of HMU was observed upon re-aeration indicating oxygen may have been limiting during some periods although degradation of intermediate metabolites to terminal metabolites was still occurring, albeit at slower rates.

  16. Aerobic biodegradation of toluene-2,4-di(8:2 fluorotelomer urethane) and hexamethylene-1,6-di(8:2 fluorotelomer urethane) monomers in soils.

    PubMed

    Dasu, Kavitha; Lee, Linda S

    2016-02-01

    Aerobic soil biodegradation of toluene-2,4-di(8:2 fluorotelomer urethane) (FTU) and hexamethylene-1,6-di(8:2 fluorotelomer urethane) (HMU) in a forest soil and FTU in an agricultural silty clay loam soil was monitored for up to 6 months. Fluorotelomer alcohols were measured in headspace and parent monomers and all metabolites in soil extracts. Negligible degradation of FTU biodegradation occurred in the agricultural soil with 94 ± 15% recovered at day 180. However, in the forest soil, both FTU and HMU degradation was evident with significant losses of 24% (117 d) and 27% (180 day), respectively, and concomitant increases in the terminal metabolite, perfluorooctanoic acid (PFOA) concentrations were well above what could result from residual 8:2 FTOH. Kinetic modeling estimated half-lives for FTU (aromatic backbone) and HMU (aliphatic backbone) in the forest soil to be 3-5 months and 15.9-22.2 months, respectively. The addition of a structurally similar non-fluorinated FTU analog, toluene-2,4-dicarbamic acid diethyl ester (TDAEE) enhanced production of terminal end products from 8:2 FTOH degradation. However, there was no clear evidence that TDAEE enhanced cleavage of the urethane bond, thus TDAEE appeared to just serve as an additional carbon source. TDAEE's half-life was ∼ one week. A second addition of TDAEE appeared to retard subsequent degradation of FTU exemplifying the microbial dynamics and diversity impacting degradation of polyfluoroalkyl substances. Enhanced degradation of HMU was observed upon re-aeration indicating oxygen may have been limiting during some periods although degradation of intermediate metabolites to terminal metabolites was still occurring, albeit at slower rates. PMID:26624955

  17. Validating Geant4 Versions 7.1 and 8.3 Against 6.1 for BaBar

    SciTech Connect

    Banerjee, Swagato; Brown, David N.; Chen, Chunhui; Cote, David; Dubois-Felsmann, Gregory P.; Gaponenko, Igor; Kim, Peter C.; Lockman, William S.; Neal, Homer A.; Simi, Gabriele; Telnov, Alexandre V.; Wright, Dennis H.; /SLAC

    2011-11-08

    Since 2005 and 2006, respectively, Geant4 versions 7.1 and 8.3 have been available, providing: improvements in modeling of multiple scattering; corrections to muon ionization and improved MIP signature; widening of the core of electromagnetic shower shape profiles; newer implementation of elastic scattering for hadronic processes; detailed implementation of Bertini cascade model for kaons and lambdas, and updated hadronic cross-sections from calorimeter beam tests. The effects of these changes in simulation are studied in terms of closer agreement of simulation using Geant4 versions 7.1 and 8.3 as compared to Geant4 version 6.1 with respect to data distributions of: the hit residuals of tracks in BABAR silicon vertex tracker; the photon and K{sub L}{sup 0} shower shapes in the electromagnetic calorimeter; the ratio of energy deposited in the electromagnetic calorimeter and the flux return of the magnet instrumented with a muon detection system composed of resistive plate chambers and limited-streamer tubes; and the muon identification efficiency in the muon detector system of the BABAR detector.

  18. 4,10-Dinitro-2,6,8,12-tetraoxa-4,10-diazatetracyclo[5.5.0.05,903,11]dodecane Synthesis

    NASA Astrophysics Data System (ADS)

    Maksimowski, Paweł; Gołofit, Tomasz

    2013-07-01

    4,10-Dinitro-2,6,8,12-tetraoxa-4,10-diazatetracyclo[5.5.0.05,903,11]dodecane (TEX) was obtained by nitrolysis of 1,4-diformyl-2,3,5,6-tetrahydroxypiperazine reaction using a mixture of fuming nitric acid and concentrated sulfuric acid. The optimal process temperature was 54-56°C. The yield of the synthesis depends inter alia on the rate the reactants are introduced into the reaction medium and on the time of conditioning of the reaction mixture. A maximal yield of ca. 40% was achieved at the reactant addition time of 2 h and conditioning time of 2 h. None of the other nitrating mixtures examined proved superior to the conventional nitrating mixture. The product was examined by high-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR), Fourier transform infrared (FTIR), and differential scanning calorimetry (DSC) techniques and the results are reported.

  19. Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8

    PubMed Central

    1990-01-01

    The involvement of integrins in mediating interaction of cells to well- characterized proteolytic fragments (P1, E3, and E8) of laminin was assessed by antibody blocking studies. Cell adhesion to fragment P1 was affected by mAbs against the integrin beta 1 and beta 3 subunits and furthermore could be prevented completely by a synthetic peptide containing the Arg-Gly-Asp sequence. Because the beta 3 antibody- sensitive cell lines expressed the vitronectin receptor (alpha v beta 3) at high levels, the involvement of this receptor in cell adhesion to P1 is strongly suggested. Integrin-mediated cell adhesion to E3 is of low affinity and was inhibited by antibodies against the integrin beta 1 subunit. In contrast, adhesion of some cell types to E3 was not or only partially sensitive to inhibition by anti-integrin subunit antibodies. Cell adhesion to E8 was blocked completed by integrin alpha 6 or beta 1 antibodies. The alpha 6-specific antibody did not inhibit cell adhesion to E3 or P1. Furthermore, the antibody only blocked adhesion to laminin of those cells that adhered exclusively to the E8 fragment. In addition, expression of alpha 6 beta 1 was closely correlated with the ability of cells to bind to the E8 fragment of laminin. These results indicate that the alpha 6 beta 1 integrin is a specific receptor for the E8 fragment of laminin. Many cell types expressed, instead of or in addition to alpha 6 beta 1 the recently described integrin alpha 6 beta 4. Although the ligand of alpha 6 beta 4 was not identified, it must be different from that of alpha 6 beta 1, because cells that express alpha 6 beta 4, but not alpha 6 beta 1, do not adhere to E8, and cell adhesion to E8 was specifically blocked by beta 1 specific antibodies. In conclusion, the data indicate that distinct integrin receptors belonging to the beta 1 or beta 3 subfamily are involved in adhesion of cells to the various laminin fragments. Adhesion to E3 may also be brought about by other receptor molecules

  20. Elevated Temperature Deformation of Fe-39.8Al and Fe-15.6Mn-39.4Al

    NASA Technical Reports Server (NTRS)

    Whittenberger, J. Daniel

    2004-01-01

    The elevated temperature compressive properties of binary Fe-39.8 at % Al and Fe-15.6Mn-39.4Al have been measured between 1000 and 1300 K at strain rates between 10(exp 7) and 10(exp 3)/ s. Although the Mn addition to iron aluminide did not change the basic deformation characteristics, the Mn-modified alloy was slightly weaker. In the regime where deformation of FeAl occurs by a high stress exponent mechanism (n = 6), strength increases as the grain size decreases at least for diameters between approx. 200 and approx. 10 microns. Due to the limitation in the grain size-flow stress-temperature-strain rate database, the influence of further reductions of the grain size on strength is uncertain. Based on the appearance of subgrains in deformed iron aluminide, the comparison of grain diameters to expected subgrain sizes, and the grain size exponent and stress exponent calculated from deformation experiments, it is believed that grain size strengthening is the result of an artificial limitation on subgrain size as proposed by Sherby, Klundt and Miller.

  1. Are 1,5- and 1,7-dihydrodiimidazo[4,5-b:4‧,5‧-e]pyrazine the main products of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) alkaline hydrolysis? A DFT study of vibrational spectra

    NASA Astrophysics Data System (ADS)

    Kholod, Yana; Okovytyy, Sergiy; Kuramshina, Gulnara; Qasim, Mohammad; Gorb, Leonid; Furey, John; Honea, Patricia; Fredrickson, Herbert; Leszczynski, Jerzy

    2006-08-01

    The fully optimized geometries and force fields of the most stable conformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane and two tautomers 1,5- and 1,7-dihydrodiimidazo[4,5- b:4',5'- e]pyrazine were obtained at the B3LYP level of hybrid density functional theory with the 6-31G(d) basis set. The vibrational frequencies were calculated by scaling of force fields, and the vibrational spectra were interpreted taking into account potential energy distributions. DFT calculations provide good agreement between calculated and experimental vibrational frequencies, obtained for CL-20. The theoretical vibrational spectra of 1,5- and 1,7-dihydrodiimidazo[4,5- b:4',5'- e]pyrazine correspond to the experimental FTIR spectrum obtained for the CL-20 alkaline hydrolysis products.

  2. Synthesis and structures of type-I clathrates: Rb6Na2Ge44.89(1), Cs6Na2Zn4Ge42 and Cs6.40(1)Na1.60(1)Ga8Ge38

    NASA Astrophysics Data System (ADS)

    Zhang, Hui; Mu, Gang; Huang, Fuqiang; Xie, Xiaoming

    2016-10-01

    Type-I clathrates of Rb6Na2Ge44.89(1), Cs6Na2Zn4Ge42 and Cs6.40(1)Na1.60(1)Ga8Ge38 were synthesized via solid-state reaction. Rb6Na2Ge44.89(1), Cs6Na2Zn4Ge42 and Cs6.40(1)Na1.60(1)Ga8Ge38 were found to crystalize in the cubic space group of Pm 3 ̅ n with lattice parameters of a=10.72755(5) Å, a=10.79501(8) Å and a=10.79726(5) Å, respectively. Theoretical calculations indicated semiconducting features for the calculation models of Rb6Na2Ge44, Cs6Na2Zn4Ge42 and Cs6Na2Ga8Ge38 with band gaps of 0.002 eV, 0.297 eV and 0.221 eV, respectively.

  3. Temperature-dependent framework–template interaction of |Na{sub 6}(H{sub 2}O){sub 8}|[ZnPO{sub 4}]{sub 6} sodalite

    SciTech Connect

    Robben, Lars Gesing, Thorsten M.

    2013-11-15

    The partial dehydration followed by the decomposition of sodium-zincophosphate-hydrosodalite caused by the total water loss was examined by temperature-dependent X-ray powder diffraction, Fourier transform infrared (FTIR) and Raman spectroscopy as well as thermogravimetry combined with difference thermoanalysis. The dehydration causing the decomposition of this sodalite could be described in a two step-process. Initially two water molecules per unit-cell were lost, changing the interaction between the zincophosphate framework and the remaining water molecules as well as sodium cations as non-framework constituents. In this stage a 3+3 coordination of water molecules and sodium cations in the sodalite cage is observed. Using the autocorrelation function (AC) for the evaluation of the temperature-dependent FTIR spectra of sodalites is reported here for the first time. Calculating the changes in the AC broadness, structural features could well be analyzed due to its correlation with respective structural parameters. Temperature dependent Raman data was used to give a band assignment of bands at Raman shifts below 300 cm{sup −1}. - Graphical abstract: The thermal decomposition of |Na{sub 6}(H{sub 2}O){sub 8}|[ZnPO{sub 4}]{sub 6} sodalite is a two-step process with an initial loss of two water molecules at 400 K, intermediately stabilizing the highly stressed framework. Further heating leads to a subsequent loss of the remaining six water molecules and a breakup of the sodalite framework. A beryllonite-type NaZnPO{sub 4} is the final product of this process. Display Omitted - Highlights: • The decomposition of |Na{sub 6}(H{sub 2}O){sub 8}|[ZnPO{sub 4}]{sub 6} sodalite is a two-step process. • Initial loss of two water molecule at 400 K stabilizes the sodalite (step 1). • Further heating leads to complete loss of water and structural breakdown. • Autocorrelation of temperature dependent FTIR-spectra gives structural information.

  4. Comparison of data and model simulations over 4, 6, 8 and 10 ka snapshots at high-southern latitudes

    NASA Astrophysics Data System (ADS)

    Stenni, Barbara; Mathiot, Pierre; Crosta, Xavier; Braida, Martina; Mezgec, Karin; Goosse, Hugues; Renssen, Hans; Masson-Delmotte, Valerie

    2013-04-01

    Paleotemperature reconstructions from Antarctic ice cores rely mainly on δD and δ18O records, with the main key factors controlling their observed distribution in Antarctic surface snow being related to the condensation temperature of the precipitation and the origin of the moisture. Reconstructions of past sea-surface temperatures (SST) and sea ice cover (SIC) from marine cores at high southern latitudes mainly rely on diatom-based transfer functions and on the TEX86 proxy for temperature. However, quantitative records of SST and SIC are concentrated in the mid-latitudes of the Southern Ocean and only few records exist in the Antarctic coastal areas. In the framework of the ESF PolarCLIMATE programme, the HOLOCLIP project aims to bring together the ice core, the marine core and the modelling scientific communities to understand the processes linking different components of the Antarctic climate system and linking climatic response to external forcing over the Holocene. In this study, we analyse the comparison between the paleoclimate information derived from both Antarctic ice cores and southern high latitude marine cores, and model simulations performed with the LOVECLIM model using a data assimilation method over different snapshots: 4, 6, 8 and 10 ka BP. The snapshot simulations are in general agreement with the temperature reconstructions from the proxy records. Particularly, snapshot simulations capture the cooling from 10 to 8 ka observed in some ice core and marine records. This cooling is related to the coupled impact of high-latitude atmospheric circulation changes and enhanced freshwater melting from the WAIS.

  5. Correction of aspect ratio dependency in deep silicon etch using SF6/C4F8/Ar gas mixture

    NASA Astrophysics Data System (ADS)

    Bates, Robert Lee

    The etch rate of deep features in silicon, such as trenches and vias, can vary significantly with the changing Aspect Ratio (AR) of the feature. Developing a better understanding of the complex volumetric and surface chemistry as well as the etching mechanisms controlling the Aspect Ratio Dependent Etch-rate (ARDE) continues to present research opportunities. Recall that ARDE is generally characterized by small AR features etching at faster rates than large AR features. The main causes of ARDE include Knudsen transport of neutrals into and out of the features as well as ion and neutral loss to the walls due to angular spread in the velocity distribution function and differential charging of insulating microstructures. This work focuses on using a continuous plasma process utilizing a gas mixture of SF6/C4F8/Ar to produce trenches of varying widths and depths. The experimental results were obtained using a Plasma-Therm Versaline processing system. Experiments were performed to show that the etch rate of low AR features can be reduced through the deposition of a passivation layer and thereby allow larger AR features to catch up. It is also possible to invert the ARDE in certain circumstances. We will present the insights we have gained into the ARDE process and the solutions we have tested.

  6. Preparation and Properties of the Corner-Shared Double Cube [Mo(6)BiS(8)(H(2)O)(18)](8+) as a Derivative of [Mo(3)S(4)(H(2)O)(9)](4+) in Aqueous Acidic Solutions.

    PubMed

    Saysell, David M; Sykes, A. Geoffrey

    1996-09-11

    The reaction of [Mo(3)S(4)(H(2)O)(9)](4+) with Bi(III) in the presence of BH(4)(-) (rapid), or with Bi metal shot (3-4 days), gives a heterometallic cluster product. The latter has been characterized as the corner-shared double cube [Mo(6)BiS(8)(H(2)O)(18)](8+) by the following procedures. Analyses by ICP-AES confirm the Mo:Bi:S ratio as 6:1:8. Elution from a cation-exchange column by 4 M Hpts (Hpts = p-toluenesulfonic acid), but not 2 M Hpts (or 4 M HClO(4)), is consistent with a high charge. The latter is confirmed as 8+ from the 3:1 stoichiometries observed for the oxidations with [Co(dipic)(2)](-) or [Fe(H(2)O)(6)](3+) yielding [Mo(3)S(4)(H(2)O)(9)](4+) and Bi(III) as products. Heterometallic clusters [Mo(6)MS(8)(H(2)O)(18)](8+) are now known for M = Hg, In, Tl, Sn, Pb, Sb, and Bi and are a feature of the P-block main group metals. The color of [Mo(6)BiS(8)(H(2)O)(18)](8+) in 2.0 M Hpts (turquoise) is different from that in 2.0 M HCl (green-blue). Kinetic studies (25 degrees C) for uptake of a single chloride k(f) = 0.80 M(-)(1) s(-)(1), I = 2.0 M (Hpts), and the high affinity for Cl(-) (K > 40 M(-)(1)) exceeds that observed for complexing at Mo. A specific heterometal interaction of the Cl(-) not observed in the case of other double cubes is indicated. The Cl(-) can be removed by cation-exchange chromatography with retention of the double-cube structure. Kinetic studies with [Co(dipic)(2)](-) and hexaaqua-Fe(III) as oxidants form part of a survey of redox properties of this and other clusters. The Cl(-) adduct is more readily oxidized by [Co(dipic)(2)](-) (factor of approximately 10) and is also more air sensitive.

  7. Downregulated Expression of Ly-6-ThB on Developing T Cells Marks CD4+CD8+ Subset Undergoing Selection in the Thymus

    PubMed Central

    Reese, Justin T.; Mehta, Hitesh; Chappell, Clay H.

    2001-01-01

    Interaction of TCRs on CD4+CD8+ immature T cell with MHC-peptide complexes on stromal cells is required for positive and negative selection in the thymus. Identification and characterization of a subpopulation of CD4+CD8+ thymocytes undergoing selection in the thymus will aid in understanding the mechanisms underlying lineage commitment and thymic selection. Herein, we describe the expression of Ly-6 ThB on developing thymocytes. The majority of CD4+CD8+ thymocytes express Ly-6 ThB at high levels. Its expression is downregulated in a subset of CD4+CD8+ thymocytes as well as in mature CD4+CD8- and CD4-CD8+ T cells. More importantly, interaction of TCR/coreceptor with the self-MHC-peptide contributes to the downregulation of ThB expression on developing thymocytes. These findings indicate that downregulation of ThB on CD4+CD8+ thymocytes identifies a unique subset (CD4+CD8+ThBneg–low) of thymocytes that has received the initial signals for thymic selection but have not yet downregulated the CD4 and CD8 cell surface expression. In addition, these results also indicate that a high frequency (Ÿ20–40%) of CD4+CD8+ immature thymocytes receive these initial signals during thymic selection. PMID:11589307

  8. Gold(I)-catalyzed cycloisomerization of alkynyl hydroxyallyl tosylamides to 4-oxa-6-azatricyclo[3.3.0.0(2,8)]octanes.

    PubMed

    Park, Yujung; Kim, Sun Young; Park, Ji Hoon; Cho, Jieun; Kang, Youn Kyung; Chung, Young Keun

    2011-05-14

    Reaction of alkyne allyl alcohols tethered with N-(p-tolylsulfonamide) in the presence of a cationic gold(I) catalyst gave new cycloisomerization products, 4-oxa-6-azatricyclo[3.3.0.0(2,8)]octanes. PMID:21448474

  9. Bulk deformation of Ti-6.8Mo-4.5Fe-1.5Al (timetal LCB) alloy

    NASA Astrophysics Data System (ADS)

    Weiss, I.; Srinivasan, R.; Saqib, M.; Stefansson, N.; Jackson, A. G.; Leclair, S. R.

    1996-06-01

    Recently, a low-cost near-β titanium alloy (Timetal LCB Ti-6.8Mo-4.5Fe-l.5Al wt %) containing iron and molybdenum has been developed. This alloy is cold formable in the β microstructure and can be aged to high strengths by precipitating the a phase. Due to its combination of cold formability and high strength, the alloy is a potential replacement for steel components in the automotive industry. The current study was undertaken to evaluate the cold bulk forming characteristics of Timetal LCB for use in lightweight automotive applications. Room-temperature compression tests conducted over a strain-rate range of 0.01 to 5/s indicate that the bulk cold compression of the alloy is affected by two factors: the microstructure and the length-to-diameter aspect ratio of the specimen. In the aged condition, when the microstructure has a-phase particles distributed along flow lines in the β-phase matrix, the alloy has the propensity for shear failure when deformed in compression in a direction parallel to the flow lines. In the solution-heat-treated condition, the microstructure consists of β grains with athermal ω phase. In this condition, the alloy can be cold compressed to 75 % reduction in height using specimens with aspect ratio of 1.125, but fails by shear for a larger aspect ratio of 1.5. Plastic deformation of the material occurs initially by single slip in most grains, but changes to multiple slip at true plastic strains larger than about 0.15. At a slow strain rate, the deformation is uniform, and the material work hardens continuously. At high strain rates, shear bands develop, and the localized deformation and temperature rise due to deformation heating leads to flow softening during compression. Although there is a considerable rise in temperature (200 to 500 °) during deformation, precipitation of the a phase was not observed.

  10. Synthesis of 4,10-Dinitro-2,6,8,12-tetraoxa-4,10-diazaisowurtzitane (TEX) Using Heteropolyacids as Efficient and Recyclable Heterogeneous Catalysts

    NASA Astrophysics Data System (ADS)

    Bayat, Yadollah; Azizkhani, Vahid

    2012-07-01

    4,10-Dinitro-2,6,8,12-tetraoxa-4,10-diazaisowurtzitane (TEX) is well known as an efficient explosive compound. It is usually prepared via nitration of a precursor with a mixture of concentrated nitric and sulfuric acid. However, there are many difficulties with the use of old methods, such as strong acidic and thermal conditions, which cause product decomposition, low yields, hazardous wastes, and product separation difficulties. In this article, the use of an efficient catalytic and mild reaction conditions for TEX synthesis is reported for the first time. It has been well documented that heteropolyacids (HPAs) are efficient green catalysts for use as a nitric acid activator. This strategy provided milder and higher yield conditions for nitration reactions. In addition, the reactions can be reasonably run at lower temperatures in a short time.

  11. Analysis of the Vibrational Spectra of P_3N_3(OCH_2CF_3)_6 and P_4N_4(OCH_2CF_3)_8

    NASA Astrophysics Data System (ADS)

    King, Adrian K.; Plant, David F.; Golding, Peter; Lawson, Michael A.; Davies, Paul B.

    2011-06-01

    The cyclic phosphazene trimer P_3N_3(OCH_2CF_3)_6 and the related cyclic tetramer P_4N_4(OCH_2CF_3)_8 have been proposed as the major low-to-medium temperature pyrolysis products of the parent polyphosphazene (PN(OCH_2CF_3)_2)_n. Recently, both molecules have been synthesized, isolated and their vapour-phase vibrational spectra recorded using a high-resolution FTIR instrument. The interpretation of these spectra is achieved primarily by comparison with the results of high-quality density functional calculations, which enable the principal absorption features to be assigned and conclusions to be drawn regarding the geometries and conformations adopted by both molecules. These in turn allow interesting comparisons to be made with analogous cyclic halo-phosphazenes such as P_3N_3Cl_6 and P_4N_4Cl_8. Work to record in situ the spectra of the vapour-phase pyrolysis products of (PN(OCH_2CF_3)_2)_n and to analyse these results in terms of the tetramer and trimer spectra will also be presented. S. V. Peddada and J. H. Magill Macromolecules 16 (1983) 1258-1264. H. R. Allcock, G. S. McDonnell, G. H. Riding, and I. Manners Chem. Mater. 2 (1990) 425-432. T. R. Manley and D. A. Williams Spectrochimica Acta 23A (1966) 149-165. V. Varma, J. R. Fernandez and C. N. R. Rao J. Mol. Struct. 198 (1989) 403-412.

  12. Dimeric procyanidins: screening for B1 to B8 and semisynthetic preparation of B3, B4, B6, And B8 from a polymeric procyanidin fraction of white willow bark (Salix alba).

    PubMed

    Esatbeyoglu, Tuba; Wray, Victor; Winterhalter, Peter

    2010-07-14

    Fifty-seven samples have been analyzed with regard to the occurrence of dimeric procyanidins B1-B8 as well as the composition of polymeric procyanidins. Fifty-two samples were found to contain polymeric procyanidins. In most of the samples, (-)-epicatechin was the predominant unit present. In white willow bark (Salix alba), however, large amounts of (+)-catechin (81.0%) were determined by means of phloroglucinolysis. White willow bark has therefore been used for the semisynthetic formation of dimeric procyanidins B3 [(+)-C-4alpha --> 8-(+)-C)], B4 [(+)-C-4alpha --> 8-(-)-EC)], B6 [(+)-C-4alpha --> 6-(+)-C)], and B8 [(+)-C-4alpha --> 6-(-)-EC)]. The reaction mixtures of the semisynthesis were successfully fractionated with high-speed countercurrent chromatography (HSCCC), and dimeric procyanidins B3, B4, B6, and B8 were obtained on a preparative scale.

  13. Site characterization plan: Yucca Mountain Site, Nevada Research and Development Area, Nevada: Volume 6, Part B: Chapter 8, Sections 8.3.2 through 8.3.4.4

    SciTech Connect

    1988-12-01

    This site characterization plan (SCP) has been developed for the candidate repository site at Yucca Mountain in the State of Nevada. The SCP includes a description of the Yucca Mountain site (Chapters 1-5), a conceptual design for the repository (Chapter 6), a description of the packaging to be used for the waste to be emplaced in the repository (Chapter 7), and a description of the planned site characterization activities (Chapter 8). The schedules and milestones presented in Sections 8.3 and 8.5 of the SCP were developed to be consistent with the June 1988 draft Amendment to the DOE`s Mission Plan for the Civilian Radioactive Waste Management Program. The five month delay in the scheduled start of exploratory shaft construction that was announced recently is not reflected in these schedules. 35 figs., 70 tabs.

  14. Proceedings of the International Conference on Educational Data Mining (EDM) (4th, Eindhoven, the Netherlands, July 6-8, 2011)

    ERIC Educational Resources Information Center

    Pechenizkiy, Mykola; Calders, Toon; Conati, Cristina; Ventura, Sebastian; Romero, Cristobal; Stamper, John

    2011-01-01

    The 4th International Conference on Educational Data Mining (EDM 2011) brings together researchers from computer science, education, psychology, psychometrics, and statistics to analyze large datasets to answer educational research questions. The conference, held in Eindhoven, The Netherlands, July 6-9, 2011, follows the three previous editions…

  15. Design, Synthesis and Biological Evaluation of 5-Oxo-1,4,5,6,7,8 Hexahydroquinoline Derivatives as Selective Cyclooxygenase-2 Inhibitors

    PubMed Central

    Zarghi, Afshin; Sabakhi, Iman; Topuzyan, Vigen; Hajimahdi, Zahra; Daraie, Bahram

    2014-01-01

    A group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a COX-2 SO2Me pharmacophore at the para position of the C-2 or C-4 phenyl ring, in conjunction with a C-4 or C-2 phenyl (4-H) or substituted-phenyl ring (4-F,4-Cl,4-Br,4-OMe,4-Me, 4-NO2), were designed for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors. These target 5-oxo-1,4,5,6,7,8 hexahydroquinolines were synthesized via a Hansch condensation reaction. In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 7,8-dihydro- 7,7-dimethyl-2-(4-methoxyphenyl)-4-(4-(methylsulfonyl)phenyl)quinolin-5(1H,4H,6H)- one (9c) as a potent COX-2 inhibitor (IC50 = 0.17 M) with a high COX-2 selectivity index (S.I. = 97.6) comparable to the reference drug celecoxib (COX-2 IC50 = 0.05 mM; COX-2 S.I= 405). A molecular modeling study where 9c was docked in active site of COX-2 showed that the p-SO2Me substituent on the C-2 phenyl ring is inserted into the secondary COX-2 binding site. The structure activity data acquired indicate that the position of the COX-2 SO2Me pharmacophore and type of substituent are important for COX-2 inhibitory activity. PMID:24711830

  16. Extended analysis of the high resolution spectrum of C2H6 near 7 μm: the ν6, ν8, ν4 + ν12, 2ν4 + ν9 vibrational system, and associated hot transitions

    NASA Astrophysics Data System (ADS)

    Lattanzi, F.; di Lauro, C.; Vander Auwera, J.

    2011-09-01

    The room temperature high resolution infrared spectrum of C2H6 between 1330 and 1610 cm-1, the region of the ν6 and ν8 fundamentals, has been re-investigated owing to the relevance of this spectral region in atmospheric and planetary applied research. The assignments of transitions from the ground vibrational state to the upper states ν6, ν8, ν4 + ν12 and 2ν4 + ν9 (4592 in total) and from the lower state ν4 to the upper state ν4 + ν8 (1090 lines) have been considerably extended with respect to our previous work [F. Lattanzi, C. di Lauro and J. Vander Auwera, J. Mol. Spectrosc. 248 (2008) 134-145], especially for the hot transitions. In particular, three new series of perturbation activated transitions were found, with ΔK = ±2, made observable by the resonance of the type l(Δl = ±2, ΔK = ∓1) within ν8. Also, new P-transitions to ν6 were found, made observable by the x,y-Coriolis resonance with ν8, at the values of K from 15 to 18. The extension of the assignments in the high frequency wing of ν8 and their analysis allowed the discovery of two additional resonance interactions. The first interaction, a higher order Coriolis-type between ν8(±K, l = ±1) and ν6(±K ± 2, l = 0), induces a few detectable transitions to ν6 with ΔK = 3. The second interaction, of the type l(Δl = ±2, ΔK = ∓1), comes to resonance between ν8(k = ±19, l = ±1) and 2ν4 + ν9 (k = ±20, l = ∓1). This last resonance and the x,y-Coriolis resonance of ν6 and 2ν4 + ν9 allows one to observe several transitions to the 2ν4 + ν9 vibrational state. The extension of the assignments in the (ν4 + ν8) - ν4 hot band allowed discovery of a resonance interaction of the type l(Δl = ±2, ΔK = ∓1) between the states ν4 + ν8 and 2ν4 + ν12, in addition to their well known Fermi-type interaction. The K-values before and after the level crossing could be determined for both interactions. Better values were also determined for the J-structure parameters B, DJ and

  17. 4,4,6a,6b,11,12,14b-Heptamethyl-16-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,9,10,11,12,12a,14a,14b-octa­deca­hydro-12b,8a-(epoxy­methano)­picen-3-yl acetate

    PubMed Central

    Nisar, Mohammad; Ali, Sajid; Tahir, M. Nawaz; Ahmad, Bashir; Hameed, Shahid

    2013-01-01

    The title compound, C32H48O4, which was extracted from the bark of Rhododendron arboreum, consists of five fused rings to which an acetate and seven methyl groups are attached. The A, D and E rings adopt chair conformations, the B ring is in a distorted chair and the C ring is in a half-chair conformation. The five-membered ring formed by the lactone group, which bridges from the A/B to the B/C ring junctions, is an approximate envelope with the C atom of the methyne group as the flap [displacement from the other four atoms = 0.753 (2) Å]. There are no identified directional inter­actions in the crystal structure. PMID:23634108

  18. Theoretical investigations of a high density cage compound 10-(1-nitro-1, 2, 3, 4-tetraazol-5-yl)) methyl-2, 4, 6, 8, 12-hexanitrohexaazaisowurtzitane.

    PubMed

    Zhang, Jian-ying; Du, Hong-chen; Wang, Fang; Gong, Xue-dong; Huang, Yin-sheng

    2012-01-01

    A new polynitro cage compound with the framework of HNIW and a tetrazole unit, i.e., 10-(1-nitro-1, 2, 3, 4-tetraazol-5-yl)) methyl-2, 4, 6, 8, 12-hexanitrohexaazaisowurtzitane (NTz-HNIW) has been proposed and studied by density functional theory (DFT) and molecular mechanics methods. Properties such as IR spectrum, heat of formation, thermodynamic properties, and crystal structure were predicted. The compound belongs to the Pbca space group, with the lattice parameters a = 15.07 Å, b = 12.56 Å, c = 18.34 Å, Z = 8, and ρ = 1.990 g·cm(-3). The stability of the compound was evaluated by the bond dissociation energies and results showed that the first step of pyrolysis is the rupture of the N-NO(2) bond in the side chain. The detonation properties were estimated by the Kamlet-Jacobs equations based on the calculated crystal density and heat of formation, and the results were 9.240 km·s(-1) for detonation velocity and 40.136 GPa for detonation pressure. The designed compound has high thermal stability and good detonation properties and is probably a promising high energy density compound (HEDC).

  19. Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines.

    PubMed

    Faessel, H M; Slocum, H K; Rustum, Y M; Greco, W R

    1999-03-01

    Folic acid (PteGlu)-enhanced intense synergy has been observed between nonpolyglutamylatable dihydrofolate reductase (DHFR) inhibitors and polyglutamylatable inhibitors of other folate-requiring enzymes, such as glycinamide ribonucleotide formyltransferase (GARFT) and thymidylate synthase. Since this phenomenon is potentially therapeutically useful, we explored its universality by examining the combined action of a DHFR inhibitor, trimetrexate (TMQ), with a GARFT inhibitor, 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]++ +thiazin-6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034), in eight human cultured cell lines. Using a 96-well plate cell growth inhibition assay, four ileocecal adenocarcinoma cell lines [HCT-8, HCT-8/DW2 (Tomudex-resistant), HCT-8/DF2 (Tomudex-/FdUrd-resistant), and HCT-8/50 (adapted to 50 nM PteGlu)], three head and neck carcinoma cell lines [A253, FaDu, and Hep-2/500 (FdUrd-resistant)], and a non-small cell lung carcinoma cell line [H460] were treated for 96 hr with TMQ + AG2034 in the presence of 23 or 40 microM PteGlu. Cell growth was measured with the sulforhodamine B assay at the end of this period. Drug interactions were assessed by fitting a 7-parameter model including a synergism parameter, alpha, to data with weighted nonlinear regression. Isobologram analysis was also applied. At 23 microM PteGlu, cells exhibited similar intensities of Loewe synergy for the combination of TMQ + AG2034. Loewe synergy was abolished in HCT-8/50 cells cultured and studied in 50 nM PteGlu. At 40 microM PteGlu, the intensity of the combined action in all cell lines was increased However, the most intense Loewe synergy was seen with HCT-8, HCT-8/DF2, H460, FaDu, A253, and Hep-2/500 cells, whereas the HCT-8/50 subculture showed less of the phenomenon, and PteGlu enhancement was the least with HCT-8/DW2, a subline deficient in folylpolyglutamate synthetase (FPGS). The universality of the PteGlu-enhanced intense synergy phenomenon

  20. Synthesis, optical and photoelectrical characterizations of the novel 10-chloro-6H,8H-dichromeno[2,3-b:3‧,4‧-e]pyridine-6,8-dione (CDPD) and its photodiode application

    NASA Astrophysics Data System (ADS)

    Ibrahim, Magdy A.; Farag, A. A. M.; Roushdy, N.; El-Gohary, Nasser M.

    2016-01-01

    Friedländer condensation of 2-amino-6-chlorochromone-3-carboxaldehyde (1) with 4-hydroxycoumarin (2) under basic conditions afforded 10-chloro-6H,8H-dichromeno[2,3-b:3‧,4‧-e]pyridine-6,8-dione (3) (CDPD). Structure of CDPD was deduced based on its correct elemental analysis and spectral data (IR, 1H NMR, 13C NMR and mass spectra). Crystalline structure by using X-ray diffraction confirms a polycrystalline nature of the powder and films with monoclinic system. A flower-like morphology was resolved for the high magnification images of scanning electron microscopy. Three direct optical band gaps were obtained and found to be 1.17, 2.24 and 3.40 eV, respectively. A sharp single peak of photoluminescence in the visible region was observed and centered at around 683 nm as well as another two peaks at 417 and 386 nm. Rectification characteristics of the device based CDPD indicates that the device behaves as a diode. A maximum value of photosensitivity of the device was obtained under effect of 60 mW/cm2 and bias voltage of 1.25 V. The phototransient characteristics of the device confirm that the device can be operated as a photodiode.

  1. Theoretical investigation of a novel high density cage compound 4,8,11,14,15-pentanitro-2,6,9,13-tetraoxa-4,8,11,14,15-pentaazaheptacyclo[5.5.1.1(3,11).1(5,9)] pentadecane.

    PubMed

    Lin, He; Zhu, Shun-guan; Zhang, Lin; Peng, Xin-hua; Chen, Peng-yuan; Li, Hong-zhen

    2013-03-01

    A novel polynitro cage compound 4,8,11,14,15-pentanitro-2,6,9,13-tetraoxa-4,8,11,14,15-pentaazaheptacyclo [5.5.1.1(3,11).1(5,9)]pentadecane(PNTOPAHP) has been designed and investigated at the DFT-B3LYP/6-31(d) level. Properties, such as electronic structure, IR spectrum, heat of formation, thermodynamic properties and crystal structure have been predicted. This compound is most likely to crystallize in C2/c space group, and the corresponding cell parameters are Z = 8, a = 29.78 Å, b = 6.42 Å, c = 32.69 Å, α = 90.00°, β = 151.05°, γ = 90.00° and ρ = 1.94 g/cm(3). In addition, the detonation velocity and pressure have also been calculated by the empirical Kamlet-Jacobs equation. As a result, the detonation velocity and pressure of this compound are 9.82 km/s, 44.67 GPa, respectively, a little higher than those of 4,10-dinitro-2,6,8,12-tetraoxa-4,10-diazaisowurtzitane(TEX, 9.28 km/s, 40.72 GPa). This compound has a comparable chemical stability to TEX, based on the N-NO(2) trigger bond length analysis. The bond dissociation energy ranges from 153.09 kJ mol(-1) to 186.04 kJ mol(-1), which indicates that this compound meets the thermal stability requirement as an exploitable HEDM. PMID:23111684

  2. 6 CFR 5.8 - Business information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... requirements of Executive Order 12600 (3 CFR, 1988 Comp., p. 235); or (4) The designation made by the submitter... 6 Domestic Security 1 2010-01-01 2010-01-01 false Business information. 5.8 Section 5.8 Domestic... Freedom of Information Act § 5.8 Business information. (a) In general. Business information obtained...

  3. 6 CFR 5.8 - Business information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... requirements of Executive Order 12600 (3 CFR, 1988 Comp., p. 235); or (4) The designation made by the submitter... 6 Domestic Security 1 2013-01-01 2013-01-01 false Business information. 5.8 Section 5.8 Domestic... Freedom of Information Act § 5.8 Business information. (a) In general. Business information obtained...

  4. 6 CFR 5.8 - Business information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... requirements of Executive Order 12600 (3 CFR, 1988 Comp., p. 235); or (4) The designation made by the submitter... 6 Domestic Security 1 2011-01-01 2011-01-01 false Business information. 5.8 Section 5.8 Domestic... Freedom of Information Act § 5.8 Business information. (a) In general. Business information obtained...

  5. 6 CFR 5.8 - Business information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requirements of Executive Order 12600 (3 CFR, 1988 Comp., p. 235); or (4) The designation made by the submitter... 6 Domestic Security 1 2014-01-01 2014-01-01 false Business information. 5.8 Section 5.8 Domestic... Freedom of Information Act § 5.8 Business information. (a) In general. Business information obtained...

  6. 6 CFR 5.8 - Business information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... requirements of Executive Order 12600 (3 CFR, 1988 Comp., p. 235); or (4) The designation made by the submitter... 6 Domestic Security 1 2012-01-01 2012-01-01 false Business information. 5.8 Section 5.8 Domestic... Freedom of Information Act § 5.8 Business information. (a) In general. Business information obtained...

  7. (C5H6N)4[Be6(HPO3)8]·H2O: A low-density open-framework beryllium phosphite with multidirectional 12-ring channels

    NASA Astrophysics Data System (ADS)

    Wang, Guo-Ming; Li, Jin-Hua; Zhang, Xiao; Jiang, Wen-Wen; Bao, Zhen-Zhen; Zhao, Xiao-Meng; Wang, Ying-Xia; Lin, Jian-Hua

    2014-07-01

    Employing the common pyridine (=py) solvent as the source of structure-directing agents (SDAs), a novel three-dimensional open-framework beryllium phosphite (Hpy)4[Be6(HPO3)8]·H2O (1), has been solvothermally synthesized and structurally characterized by IR, elemental analysis, thermogravimetric analysis, powder and single-crystal X-ray diffractions. It crystallizes in the orthorhombic system, space group Pbca (No. 61), a = 20.0034(4) Å, b = 20.2188(4) Å, c = 20.9731(3) Å, V = 8482.5(3) Å3, and Z = 8. The alternating connection of BeO4 tetrahedra and HPO3 pseudopyramids give rise to a (3, 4)-connected network with multidirectional intersecting 12-ring channels. The compound possesses a low density and a new {4.8.10}{42.6.8.10.12}{42.6}3{42.8.102.12}{43.62.8} topology.

  8. Untethered 4,1,2-MC2B10 supraicosahedral metallacarboranes, their C,C'-dimethyl 4,1,6-, 4,1,8- and 4,1,12-MC2B10 analogues, and DFT study of the (4,)1,2- to (4,)1,6-isomerisations of C2B11 carboranes and MC2B10 metallacarboranes.

    PubMed

    McAnaw, Amelia; Lopez, Maria Elena; Scott, Greig; Ellis, David; McKay, David; Rosair, Georgina M; Welch, Alan J

    2012-08-28

    Reduction of the tethered carborane 1,2-μ-(CH(2)SiMe(2)CH(2))-1,2-closo-C(2)B(10)H(10) followed by metallation with {CpCo} or {(p-cymene)Ru} fragments affords both C,C'-dimethyl 4,1,2-MC(2)B(10) and 4,1,6-MC(2)B(10) species. DFT calculations indicate that the barriers to isomerisation of both 4-Cp-4,1,2-closo-CoC(2)B(10)H(12) and 4-(η-C(6)H(6))-4,1,2-closo-RuC(2)B(10)H(12) to their respective 4,1,6-isomers are too high for this to be the origin of the unexpected formation of 4,1,6-MC(2)B(10) products (in marked contrast to the related isomerisation of 1,2-closo-C(2)B(11)H(13) to 1,6-closo-C(2)B(11)H(13)), and, indeed, the 4,1,2-species are recovered unchanged from refluxing toluene. Equally, the DFT-calculated profile for the isomerisation of [7,8-nido-C(2)B(10)H(12)](2-) to [7,9-nido-C(2)B(10)H(12)](2-) suggests that the unexpected formation of 4,1,6-metallacarboranes is unlikely to result from isomerisation of a reduced (nido) carborane following desilylation. Instead, the source of the 4,1,6-MC(2)B(10) compounds is traced to desilylation of 1,2-μ-(CH(2)SiMe(2)CH(2))-1,2-closo-C(2)B(10)H(10) by Li or Na prior to reduction. The supraicosahedral metallacarboranes 1,8-Me(2)-4-Cp-4,1,8-closo-CoC(2)B(10)H(10), 1,12-Me(2)-4-Cp-4,1,12-closo-CoC(2)B(10)H(10) and 1,12-Me(2)-4-(p-cymene)-4,1,12-closo-RuC(2)B(10)H(10) are also reported with all new species characterised both spectroscopically and crystallographically.

  9. Cellulose nanofibrils prepared from softwood cellulose by TEMPO/NaClO/NaClO₂ systems in water at pH 4.8 or 6.8.

    PubMed

    Tanaka, Reina; Saito, Tsuguyuki; Isogai, Akira

    2012-10-01

    Catalytic oxidation of softwood cellulose using NaClO and either 2,2,6,6-tetramethylpiperidine-1-oxyl (4-H-TEMPO) or 4-acetamido-TEMPO (4-AcNH-TEMPO) was applied with NaClO(2) used as a primary oxidant in an aqueous buffer at pH 4.8 or 6.8. When the 4-AcNH-TEMPO-mediated oxidation was applied to softwood cellulose in water at pH 4.8 and 40 °C, the carboxylate content rose to ∼1.3 mmol/g after reaction for 48 h and the DP(v) value was more than 1100. This 4-AcNH-TEMPO-oxidized softwood cellulose was mostly converted to individual nanofibrils by mechanical disintegration in water, with uniform widths of 3-4 nm and lengths greater than 1 μm.

  10. Hyperfine structure of the 4{f}^{8}5{d}^{2}6s configuration in the Tb atom

    NASA Astrophysics Data System (ADS)

    Furmann, B.; Stefanska, D.; Krzykowski, A.

    2016-01-01

    Within this work new experimental results concerning the hyperfine structure (hfs) in the terbium atom are presented. Hfs constants A and B for eight levels belonging to the even-parity configuration 4{f}85{d}26s were determined, based on the results of measurements performed using the laser-induced fluorescence method in a hollow cathode discharge at 18 spectral lines. The configuration 4{f}85{d}26s in the terbium atom was hitherto very scarcely investigated; for seven of the levels examined within this work results concerning the hfs were obtained for the first time. As a by-product, hfs constants for 12 odd-parity levels, involved as upper levels in the transitions investigated, were also determined. A preliminary attempt at a semi-empirical analysis of Tb I hfs on a multi-configuration basis, based on the results of this work, yielded a value of the one-electron {a}6s10 parameter as well as the respective radial integral {< {r}-3> }6s10, which can be compared with the values along the lanthanide elements series reported in the literature. More conclusive results can certainly be obtained once the experimental database for Tb I becomes more extensive.

  11. White emitting Ca2Tb8(SiO4)6O2:Eu2+/Eu3+ phosphors: Photoluminescence and efficient energy transfer

    NASA Astrophysics Data System (ADS)

    Yang, Che-Yuan; Das, Subrata; Som, Sudipta; Lu, Chung-Hsin

    2016-09-01

    Ca2Tb8(SiO4)6O2:Eu2+/Eu3+ phosphors were prepared via solid-state diffusion route in reducing ambience. The structural/elemental analyses indicate the formation of pure phase which accommodates both Eu2+/Eu3+ ions. The shift of Tb3+ excitation band from 238 to 295 nm and increase (1.3×) in excitation intensity with Eu concentration in Ca2Tb8(SiO4)6O2:Eu2+/Eu3+ phosphor is explained on the basis of Tb3+ to Eu3+ energy transfer. Upon various UV excitations (238-380 nm), Ca2Tb8(SiO4)6O2:Eu2+/Eu3+ showed tunable color emission including warm white light. Moreover, the emission intensity only decreased 15% after increasing the temperature to 200 °C, revealing that present phosphors can be suitable for UV-LEDs.

  12. Warm Spitzer Observations of Three Hot Exoplanets: XO-4b, HAT-P-6b, and HAT-P-8b

    NASA Astrophysics Data System (ADS)

    Todorov, Kamen O.; Deming, Drake; Knutson, Heather A.; Burrows, Adam; Sada, Pedro V.; Cowan, Nicolas B.; Agol, Eric; Desert, Jean-Michel; Fortney, Jonathan J.; Charbonneau, David; Laughlin, Gregory; Langton, Jonathan; Showman, Adam P.; Lewis, Nikole K.

    2012-02-01

    We analyze Warm Spitzer/Infrared Array Camera observations of the secondary eclipses of three planets, XO-4b, HAT-P-6b, and HAT-P-8b. We measure secondary eclipse amplitudes at 3.6 μm and 4.5 μm for each target. XO-4b exhibits a stronger eclipse depth at 4.5 μm than at 3.6 μm, which is consistent with the presence of a temperature inversion. HAT-P-8b shows a stronger eclipse amplitude at 3.6 μm and is best described by models without a temperature inversion. The eclipse depths of HAT-P-6b can be fitted with models with a small or no temperature inversion. We consider our results in the context of a postulated relationship between stellar activity and temperature inversion and a relationship between irradiation level and planet dayside temperature, as discussed by Knutson et al. and Cowan & Agol, respectively. Our results are consistent with these hypotheses, but do not significantly strengthen them. To measure accurate secondary eclipse central phases, we require accurate ephemerides. We obtain primary transit observations and supplement them with publicly available observations to update the orbital ephemerides of the three planets. Based on the secondary eclipse timing, we set upper boundaries for ecos (ω) for HAT-P-6b, HAT-P-8b, and XO-4b and find that the values are consistent with circular orbits.

  13. WARM SPITZER OBSERVATIONS OF THREE HOT EXOPLANETS: XO-4b, HAT-P-6b, AND HAT-P-8b

    SciTech Connect

    Todorov, Kamen O.; Deming, Drake; Knutson, Heather A.; Burrows, Adam; Sada, Pedro V.; Cowan, Nicolas B.; Agol, Eric; Desert, Jean-Michel; Charbonneau, David; Fortney, Jonathan J.; Laughlin, Gregory; Langton, Jonathan; Showman, Adam P.; Lewis, Nikole K.

    2012-02-10

    We analyze Warm Spitzer/Infrared Array Camera observations of the secondary eclipses of three planets, XO-4b, HAT-P-6b, and HAT-P-8b. We measure secondary eclipse amplitudes at 3.6 {mu}m and 4.5 {mu}m for each target. XO-4b exhibits a stronger eclipse depth at 4.5 {mu}m than at 3.6 {mu}m, which is consistent with the presence of a temperature inversion. HAT-P-8b shows a stronger eclipse amplitude at 3.6 {mu}m and is best described by models without a temperature inversion. The eclipse depths of HAT-P-6b can be fitted with models with a small or no temperature inversion. We consider our results in the context of a postulated relationship between stellar activity and temperature inversion and a relationship between irradiation level and planet dayside temperature, as discussed by Knutson et al. and Cowan and Agol, respectively. Our results are consistent with these hypotheses, but do not significantly strengthen them. To measure accurate secondary eclipse central phases, we require accurate ephemerides. We obtain primary transit observations and supplement them with publicly available observations to update the orbital ephemerides of the three planets. Based on the secondary eclipse timing, we set upper boundaries for ecos ({omega}) for HAT-P-6b, HAT-P-8b, and XO-4b and find that the values are consistent with circular orbits.

  14. Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application.

    PubMed

    Waidyanatha, Suramya; Ryan, Kristen

    2014-08-01

    1. Disposition of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (β-OTNE), a fragrance ingredient in variety of consumer products, was investigated following a single oral (20 mg/kg) or a dermal (55 or 550 mg/kg) dose of [(14)C]β-OTNE to male Fisher rats. 2. Following oral administration, 28% and 39% of the dose was recovered in urine and feces, respectively, 48 h following administration. About 73% of a 20 mg/kg dose was excreted in bile within 48 h post-administration supporting significant oral absorption of [(14)C]β-OTNE. 3. Following dermal application to a covered site, absorption of [(14)C]β-OTNE 96 h following application was low (ca. 14%) and dose-independent. When the dose site was uncovered, the absorption increased to ca. 33% (55 mg/kg) and ca. 72% (550 mg/kg). 4. [(14)C]β-OTNE was distributed to tissues following both routes of exposure with the highest radioactive equivalents found in bladder, liver, kidney, adipose and pancreas. 5. Elimination of [(14)C]β-OTNE equivalents in blood and tissues was slow following both oral and dermal application suggesting potential for accumulation following multiple exposure. PMID:24533629

  15. Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application.

    PubMed

    Waidyanatha, Suramya; Ryan, Kristen

    2014-08-01

    1. Disposition of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (β-OTNE), a fragrance ingredient in variety of consumer products, was investigated following a single oral (20 mg/kg) or a dermal (55 or 550 mg/kg) dose of [(14)C]β-OTNE to male Fisher rats. 2. Following oral administration, 28% and 39% of the dose was recovered in urine and feces, respectively, 48 h following administration. About 73% of a 20 mg/kg dose was excreted in bile within 48 h post-administration supporting significant oral absorption of [(14)C]β-OTNE. 3. Following dermal application to a covered site, absorption of [(14)C]β-OTNE 96 h following application was low (ca. 14%) and dose-independent. When the dose site was uncovered, the absorption increased to ca. 33% (55 mg/kg) and ca. 72% (550 mg/kg). 4. [(14)C]β-OTNE was distributed to tissues following both routes of exposure with the highest radioactive equivalents found in bladder, liver, kidney, adipose and pancreas. 5. Elimination of [(14)C]β-OTNE equivalents in blood and tissues was slow following both oral and dermal application suggesting potential for accumulation following multiple exposure.

  16. Nevadaite, (Cu2+, Al, V3+)6 [Al8 (PO4)8 F8] (OH 2 (H2O)22, a new phosphate mineral species from the Gold Quarry mine, Carlin, Eureka County, Nevada: description and crystal structure

    USGS Publications Warehouse

    Cooper, M.A.; Hawthorne, F.C.; Roberts, Andrew C.; Foord, E.E.; Erd, Richard C.; Evans, H.T.; Jensen, M.C.

    2004-01-01

    Nevadaite, (Cu2+, ???, Al, V3+)6 (PO4)8 F8 (OH)2 (H2O)22, is a new supergene mineral species from the Gold Quarry mine, near Carlin, Eureka County, Nevada, U.S.A. Nevadaite forms radiating clusters to 1 mm of prismatic crystals, locally covering surfaces more that 2 cm across; individual crystals are elongate on [001] with a length:width ratio of > 10:1 and a maximum diameter of ???30 ??m. It also occurs as spherules and druses associated with colorless to purple-black fluellite, colorless wavellite, strengitevariscite, acicular maroon-to-red hewettite, and rare anatase, kazakhstanite, tinticite, leucophosphite, torbernite and tyuyamunite. Nevadaite is pale green to turquoise blue with a pale powder-blue streak and a vitreous luster; it does not fluoresce under ultra-violet light. It has no cleavage, a Mohs hardness of ???3, is brittle with a conchoidal fracture, and has measured and calculated densities of 2.54 and 2.55 g/cm3, respectively. Nevadaite is biaxial negative, with ?? 1.540, ?? 1.548, ?? 1.553, 2V(obs.) = 76??, 2V(calc.) = 76??, pleochroic with X pale greenish blue, Y very pale greenish blue, Z blue, and with absorption Z ??? X > Y and orientation X = c, Y = a, Z = b. Nevadaite is orthorhombic, space group P21mn, a 12.123(2), b 18.999(2), c 4.961(1) A?? , V 1142.8(2) A??3, Z = 1, a:b:c = 0.6391:1:0.2611. The strongest seven lines in the X-ray powder-diffraction pattern [d in A??(I)(hkl)] are: 6.077(10)(200), 5.618(9)(130), 9.535(8)(020), 2.983(6)(241), 3.430(4)(041), 2.661(4)(061 , and 1.844(4)(352). A chemical analysis with an electron microprobe gave P2O5 32.54, Al2O3 27.07, V2O3 4.24, Fe2O3 0.07, CuO 9.24, ZnO 0.11, F 9.22, H2O (calc.) 23.48, OH ??? F -3.88, sum 102.09 wt.%; the valence states of V and Fe, and the amount of H2O, were determined by crystal-structure analysis. The resulting empirical formula on the basis of 63.65 anions (including 21.65 H2O pfu) is (CU2+2.00 Zn0.02 V3+0.98 Fe3+0.01 Al1.15)??4.16 Al8 P7.90 O32 [F8.37 (OH 1.63]??10 (H2O

  17. Coordination polymer template synthesis of hierarchical MnCo2O4.5 and MnNi6O8 nanoparticles for electrochemical capacitors electrode

    NASA Astrophysics Data System (ADS)

    Wang, Kuaibing; Xu, Jiangyan; Lu, Aimin; Shi, Ying; Lin, Zixia

    2016-08-01

    Two types of ternary metal oxides, MnCo2O4.5 and MnNi6O8 nanoparticles have been separately synthesized through chemical transformation from the corresponding bimetallic coordination polymer particles precursor under high-heating conditions. Series of electrochemical measurements are performed to examine the MnCo2O4.5 and MnNi6O8 electrodes, and the result shows that MnCo2O4.5 structure, especially for Mn/Co-600, has much higher capacitance than that of MnNi6O8 nanoparticles, indicating MnCo2O4.5 electrode is more suitable for applying in neutral electrolyte system. The Mn/Co-600 electrode exhibits a specific capacitance of 158 F g-1 at 5 mV s-1, good rate capability of 53.8% with a 20 times current density increase, good cycle performance (92.9% capacitance retention after 1000 cycles) and high power density (a specific power of 5760 W kg-1 at 4.0 A g-1) with low charge transfer resistance value of 1.8 Ω.

  18. Thermally stable compositions including 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt

    DOEpatents

    Hiskey, Michael A.; Huynh, My Hang

    2010-01-26

    An explosive formulation including 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt and a high temperature binder is disclosed together with a process of preparing 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt.

  19. 11 CFR 8.4 - Contents.

    Code of Federal Regulations, 2010 CFR

    2009-01-01

    ... voter identification number, the state's Privacy Act notice required at 11 CFR 8.6(c) shall be reprinted... 11 Federal Elections 1 2009-01-01 2009-01-01 false Contents. 8.4 Section 8.4 Federal Elections... Voter Registration Form § 8.4 Contents. (a) Information about the applicant. The application...

  20. 11 CFR 8.4 - Contents.

    Code of Federal Regulations, 2013 CFR

    2008-01-01

    ... voter identification number, the state's Privacy Act notice required at 11 CFR 8.6(c) shall be reprinted... 11 Federal Elections 1 2008-01-01 2008-01-01 false Contents. 8.4 Section 8.4 Federal Elections... Voter Registration Form § 8.4 Contents. (a) Information about the applicant. The application...

  1. Modeling, Synthesis and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Novel Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254)

    PubMed Central

    Jurutka, Peter W.; Kaneko, Ichiro; Yang, Joanna; Bhogal, Jaskaran S.; Swierski, Johnathon C.; Tabacaru, Christa R.; Montano, Luis A.; Huynh, Chanh C.; Jama, Rabia A.; Mahelona, Ryan D.; Sarnowski, Joseph T.; Marcus, Lisa M.; Quezada, Alexis; Lemming, Brittney; Tedesco, Maria A.; Fischer, Audra J.; Mohamed, Said A.; Ziller, Joseph W.; Ma, Ning; Gray, Geoffrey M.; van der Vaart, Arjan; Marshall, Pamela A.; Wagner, Carl E.

    2014-01-01

    Three unreported analogs of 4-[1-(3,5,5,8,8-pentamethyl-5-6-7-8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), otherwise known as bexarotene, as well as four novel analogs of (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254) are described, and evaluated for their retinoid-X-receptor (RXR)-selective agonism. Compound 1 has FDA approval as a treatment for cutaneous T-cell lymphoma (CTCL); though, treatment with 1 can elicit side-effects by disrupting other RXR-heterodimer receptor pathways. Of the 7 modeled novel compounds, all analogs stimulate RXR-regulated transcription in mammalian-2-hybrid and RXRE-mediated assays, possess comparable or elevated biological activity based on EC50 profiles, and retain similar or improved apoptotic activity in CTCL assays compared to 1. All novel compounds demonstrate selectivity for RXR and minimal crossover onto the retinoic-acid-receptor (RAR) compared to all-trans-retinoic acid, with select analogs also reducing inhibition of other RXR-dependent pathways (e.g., VDR-RXR). Our results demonstrate that further improvements in biological potency and selectivity of bexarotene can be achieved through rational drug design. PMID:24180745

  2. Synthetic Tuning of Redox, Spectroscopic, and Photophysical Properties of {Mo6I8}(4+) Core Cluster Complexes by Terminal Carboxylate Ligands.

    PubMed

    Mikhailov, Maxim A; Brylev, Konstantin A; Abramov, Pavel A; Sakuda, Eri; Akagi, Soichiro; Ito, Akitaka; Kitamura, Noboru; Sokolov, Maxim N

    2016-09-01

    The reactions between the tetra-n-butylammonium salt of [{Mo6I8}I6](2-) and silver carboxylates RCOOAg (R = CH3 (1), C(CH3)3 (2), α-C4H3O (3), C6H5 (4), α-C10H7 (5), or C2F5 (6)) in CH2Cl2 afforded new carboxylate complexes [{Mo6I8}(RCOO)6](2-). The complexes were characterized by X-ray single-crystal diffraction and elemental analysis, cyclic/differential pulse voltammetry, and IR, NMR, and UV-visible spectroscopies. The emission properties of the complexes 1-6, and those of the earlier reported complexes with R = CF3 (7) and n-C3F7 (8), were studied both in acetonitrile solution and in the solid state. In deaerated CH3CN at 298 K, all of the complexes 1-8 exhibit intense and long-lived emission with the quantum yield and lifetime being 0.48-0.73 and 283-359 μs, respectively. The oxidation (Eox)/reduction (Ered) potentials of the complexes correlate linearly with the pKa value of the terminal carboxylate ligands L = RCOO (pKa(L)). Reflecting the pKa(L) dependences of Eox/Ered, the emission energy (νem) of the complexes was also shown to correlate with pKa(L). The present study successfully demonstrates synthetic tuning of the redox, spectroscopic, and photophysical characteristics of a {Mo6I8}(4+)-based cluster complex with pKa(L). PMID:27505303

  3. Chromosomal assignment of six genes (EIF4G3, HSP90, RBBP6, IL8, TERT, and TERC) in four species of the genus Equus.

    PubMed

    Vidale, Pamela; Piras, Francesca M; Nergadze, Solomon G; Bertoni, Livia; Verini-Supplizi, Andrea; Adelson, David; Guérin, Gérard; Giulotto, Elena

    2011-01-01

    We mapped six genes (EIF4G3, HSP90, RBBP6, IL8, TERT, and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization. Our results add six type I markers to the cytogenetic map of these species and provide new information on the comparative genomics of the genus Equus.

  4. Genetic and antigenic characteristics of ApxIIA and ApxIIIA from Actinobacillus pleuropneumoniae serovars 2, 3, 4, 6, 8 and 15.

    PubMed

    To, Ho; Nagai, Shinya; Iwata, Akira; Koyama, Tomohiro; Oshima, Atsushi; Tsutsumi, Nobuyuki

    2016-07-01

    Apx toxins produced by Actinobacillus pleuropneumoniae are essential components of new generation vaccines. In this study, apxIIA and apxIIIA genes of serovars 2, 3, 4, 6, 8 and 15 were cloned and sequenced. Amino acid sequences of ApxIIA proteins of serovars 2, 3, 4, 6, 8 and 15 were almost identical to those of serovars 1, 5, 7, 9 and 11-13. Immunoblot analysis showed that rApxIIA from serovars 2 and 15 reacts strongly with sera from animals infected with various serovars. Sequence analysis revealed that ApxIIIA proteins has two variants, one in strains of serovar 2 and the other in strains of serovars 3, 4, 6, 8 and 15. A mouse cross-protection study showed that mice actively immunized with rApxIIIA/2 or rApxIIIA/15 are protected against challenge with A. pleuropneumoniae strains of serovars 3, 4, 6, 8, 15, and 2 expressing ApxIII/15 and ApxIII/2, respectively. Similarly, mice passively immunized with rabbit anti-rApxIIIA/2 or anti-rApxIIIA/15 sera were found to be protected against challenge with strains of serovars 2 and 15. Our study revealed antigenic and sequence similarities within ApxIIA and ApxIIIA proteins, which may help in the development of effective vaccines against disease caused by A. pleuropneumoniae.

  5. Czochralski growth of Sr2Tb8(SiO4)6O2 crystals for visible-near IR magneto-optical applications

    NASA Astrophysics Data System (ADS)

    Chen, Xin; Zhang, Wenhui; Wan, Qiping; Guo, Feiyun; Zhuang, Naifeng; Fu, Hao; Xie, Xitong; Chen, Jianzhong

    2014-11-01

    Sr2Tb8(SiO4)6O2 crystals have been grown and investigated for the first time for magneto-optical applications. The X-ray powder diffraction confirms that the compound crystallizes in the hexagonal system, with a common oxyapatite structure. The as-grown crystal exhibits low thermal expansion anisotropy (αa/αc ≈ 1.1), and the hardness is about 5.0 Moh. The temperature dependence of the magnetic susceptibility indicated that the Sr2Tb8(SiO4)6O2 crystal exhibits paramagnetic behavior over the experimental temperature-range 2-300 K. The present investigations demonstrate that Sr2Tb8(SiO4)6O2 crystals show a higher visible transparency and a larger Faraday rotation than terbium gallium garnet (TGG) crystals. Sr2Tb8(SiO4)6O2 is therefore a very promising material in particular for new magneto-optical applications in the visible-near IR wavelength region.

  6. CO Substitution in HOs3(CO)10(l-SC6H4Me-4) by the Diphosphine 4,5-Bis(diphenylphosphino)-4-cyclopentadiene-1,3-dione (bpcd): Structural and DFT Evaluation of the Isomeric Clusters HOs3(CO)8(bpcd)(mu-SC6H4Me-4)

    SciTech Connect

    Yang, Li; Nesterov, Vladimir; Wang, Xiaoping; Richmond, Michael G.

    2012-01-01

    The reaction of the cluster HOs{sub 3}(CO){sub 10}({mu}-SC{sub 6}H{sub 4}Me-4) (1) with the diphosphine 4,5-bis(diphenylphosphino)-4-cyclopentadiene-1,3-dione (bpcd) has been investigated. 1 reacts with bpcd at room temperature in the presence of Me{sub 3}NO to give the isomeric clusters 1,2-HOs{sub 3}(CO)8(bpcd)({mu}-SC{sub 6}H{sub 4}Me-4) (2a) and 1,1-HOs{sub 3}(CO)8(bpcd)({mu}-SC{sub 6}H{sub 4}Me-4) (2b). Clusters 2a and 2b have been isolated, and the molecular structure of each compound has been established by X-ray crystallography. The X-ray structure of 2a confirms the coordination of one of the non-hydride-bridged Os-Os vectors by the bpcd ligand, while the structure of 2b exhibits a chelating bpcd ligand that is bound to one of the osmium centers ligated by the thiolate and hydrido ligands. 2a and 2b are stable in refluxing toluene and show no evidence for bridge-to-chelate isomerization of the ancillary bpcd ligand. DFT calculations on 2a and 2b indicate that the former cluster is the thermodynamically more stable isomer. Near-UV irradiation of 2b leads to CO loss and ortho metalation of the thiolate moiety, yielding the dihydride cluster H{sub 2}Os{sub 3}(CO)7(bpcd)({mu},{sigma}-SC{sub 6}H{sub 3}Me-4) (3). The conversion of 2b to 3 and free CO is computed to be endothermic by 14.1 kcal/mol and the reaction is driven by the entropic release of CO. The photochemically promoted ortho-metalation reaction is isomer dependent since cluster 2a is inert under identical conditions.

  7. 8-Hydr­oxy-8-phenyl-2,3,7,8-tetra­hydro-6H-1,4-dioxino[2,3-f]isoindol-6-one

    PubMed Central

    Tafeenko, Viktor A.; Aslanov, Leonid A.; Khasanov, Mahmud I.; Mochalov, Sergei S.

    2008-01-01

    In the title compound, C16H13NO4, the indole system is essentially planar, whereas the dioxane ring adopts a twist conformation. The mol­ecules are linked into chains by —O— H⋯O=C— hydrogen bonds and these chains are linked into rods by means of N—H⋯O hydrogen bonds. Exept for weak C—H⋯O inter­actions between the rods, no other inter­molecular contacts of inter­est are present. PMID:21201891

  8. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors.

    PubMed

    Asano, Shigehiro; Komiya, Masafumi; Koike, Nobuyuki; Koga, Erina; Nakatani, Shogo; Isobe, Yoshiaki

    2010-11-15

    A novel series of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines containing substituted phenyl sulfonamide are synthesized and evaluated for their inhibitory activity against CaMKII. Substituents on the phenyl group had significant impact on CaMKII inhibition, in particular, the inhibitory activity of 8p was 25-fold higher than that of KN-93, a known CaMKII inhibitor. Michaelis-Menten analysis of a representative compound suggested that the synthesized pyrimidines are calmodulin non-competitive inhibitors. Finally, 8p exhibited more than 100-fold higher selectivity for CaMKII over five types of off-target kinases. PMID:20875738

  9. A spiro[chroman-3,7'-isochromene]-4,6'(8'H)-dione from the Cordyceps-colonizing fungus Fimetariella sp.

    PubMed

    Li, Erwei; Zhang, Fan; Niu, Shubin; Liu, Xingzhong; Liu, Gang; Che, Yongsheng

    2012-07-01

    Fimetarone A (1), a metabolite with the new spiro[chroman-3,7'-isochromene]-4,6'(8'H)-dione skeleton, was isolated from cultures of the Cordyceps-colonizing fungus Fimetariella sp. Compound 1 was a 1:1 atropdiastereomeric mixture in NMR data, and aS,9S and aR,9R enantiomers were found and confirmed by X-ray crystallography. Compound 1 could be derived from the hypothetical precursors 3,4,5-trihydroxy-2-(2-methylene-3,5-dioxohexanoyl)benzoic acid (5) and lapidosin (6). PMID:22726106

  10. Radiation-induced amorphization of Ce-doped Mg2Y8(SiO4)6O2 silicate apatite

    NASA Astrophysics Data System (ADS)

    Zhou, Jianren; Yao, Tiankai; Lian, Jie; Shen, Yiqiang; Dong, Zhili; Lu, Fengyuan

    2016-07-01

    Ce-doped Mg2Y8(SiO4)6O2 silicate apatite (Ce = 0.05 and 0.5) were irradiated with 1 MeV Kr2+ ion beam irradiation at different temperatures and their radiation response and the cation composition dependence of the radiation-induced amorphization were studied by in situ TEM. The two Ce-doped Mg2Y8(SiO4)6O2 silicate apatites are sensitive to ion beam induced amorphization with a low critical dose (0.096 dpa) at room temperature, and exhibits significantly different radiation tolerance at elevated temperatures. Ce concentration at the apatite AI site plays a critical role in determining the radiation response of this silicate apatite, in which the Ce3+ rich Mg2Y7.5Ce0.5(SiO4)6O2 displays lower amorphization susceptibility than Mg2Y7.95Ce0.05(SiO4)6O2 with a lower Ce3+ occupancy at the AI sites. The critical temperature (Tc) and activation energy (Ea) change from 667.5 ± 33 K and 0.162 eV of Mg2Y7.5Ce0.5(SiO4)6O2 to 963.6 ± 64 K and 0.206 eV of Mg2Y7.95Ce0.05(SiO4)6O2. We demonstrate that the radiation tolerance can be controlled by varying the chemical composition, and enhanced radiation tolerance is achieved by increasing the Ce concentration at the AI site.

  11. Stereoselective Total Synthesis of Atractylodemayne A, a Conjugated 2(E),8(Z),10(E)-Triene-4,6-diyne.

    PubMed

    Schmidt, Bernd; Audörsch, Stephan

    2016-03-01

    The first total synthesis of the polyacetylene natural product atractylodemayne A is reported. Stereoselective construction of the conjugated 8(Z),10(E)-diene moiety was achieved through a tethered ring-closing metathesis approach, comprising a Ru-catalyzed RCM followed by a base-induced elimination. A Pd-catalyzed Cadiot-Chodkiewicz coupling was used for the synthesis of the diyne. Overall, atractylodemayne A was synthesized in nine steps for the longest linear sequence. PMID:26886865

  12. 1,5-Dichloro-3(2,7),7(2,7)-dinaphthal-ena-2,4,6,8-tetra-oxa-1(2,6),5(2,6)-di(1,3,5-triazina)octa-phane.

    PubMed

    Sang, Qiu-Guang; Yang, Jing-Kui

    2011-09-01

    In the macrocyclic title compound, C(26)H(12)Cl(2)N(6)O(4), an O-atom-bridged calix[2]naphthalene-[2]triazine synthesized using a one-pot approach from naphthalene-2,7-diol and cyanuric chloride, the two isolated naphthalene planes and the two triazine-2,6-di-oxy planes adopt a 1,3-alternate configuration, with a dihedral angle of 84.10 (8)° between the naphthalene rings and a dihedral angle of 39.02 (14)° between the triazine rings. In the crystal, weak inter-molecular π-π stacking inter-actions are found between face-to-face naphthalene rings [centroid-centroid distance = 3.662 (7) Å].

  13. DNA Sequence Modulates Geometrical Isomerism of the trans-8,9- Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)- 9-hydroxy Aflatoxin B1 Adduct.

    PubMed

    Li, Liang; Brown, Kyle L; Ma, Ruidan; Stone, Michael P

    2015-02-16

    Aflatoxin B(1) (AFB(1)), a mycotoxin produced by Aspergillus flavus, is oxidized by cytochrome P450 enzymes to aflatoxin B(1)-8,9-epoxide, which alkylates DNA at N7-dG. Under basic conditions, this N7-dG adduct rearranges to yield the trans-8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxy aflatoxin B(1) (AFB(1)−FAPY) adduct. The AFB(1)−FAPY adduct exhibits geometrical isomerism involving the formamide moiety. NMR analyses of duplex oligodeoxynucleotides containing the 5′-XA-3′, 5′-XC-3′, 5′-XT-3′, and 5′-XY-3′ sequences (X = AFB(1)−FAPY; Y = 7-deaza-dG)demonstrate that the equilibrium between E and Z isomers is controlled by major groove hydrogen bonding interactions.Structural analysis of the adduct in the 5′-XA-3′ sequence indicates the preference of the E isomer of the formamide group,attributed to formation of a hydrogen bond between the formyl oxygen and the N(6) exocyclic amino group of the 3′-neighboradenine. While the 5′-XA-3′ sequence exhibits the E isomer, the 5′-XC-3′ sequence exhibits a 7:3 E:Z ratio at equilibrium at 283K. The E isomer is favored by a hydrogen bond between the formyl oxygen and the N(4)-dC exocyclic amino group of the 3′-neighbor cytosine. The 5′-XT-3′ and 5′-XY-3′ sequences cannot form such a hydrogen bond between the formyl oxygen and the 3′-neighbor T or Y, respectively, and in these sequence contexts the Z isomer is favored. Additional equilibria between α and β anomers and the potential to exhibit atropisomers about the C5−N(5) bond do not depend upon sequence. In each of the four DNA sequences, the AFB(1)−FAPY adduct maintains the β deoxyribose configuration. Each of these four sequences feature the atropisomer of the AFB(1) moiety that is intercalated above the 5′-face of the damaged guanine. This enforces the Ra axialc onformation for the C5−N(5) bond.

  14. Global emission estimates and radiative impact of C4F10, C5F12, C6F14, C7F16 and C8F18

    NASA Astrophysics Data System (ADS)

    Ivy, D. J.; Rigby, M.; Baasandorj, M.; Burkholder, J. B.; Prinn, R. G.

    2012-08-01

    Global emission estimates based on new atmospheric observations are presented for the acylic high molecular weight perfluorocarbons (PFCs): decafluorobutane (C4F10), dodecafluoropentane (C5F12), tetradecafluorohexane (C6F14), hexadecafluoroheptane (C7F16) and octadecafluorooctane (C8F18). Emissions are estimated using a 3-dimensional chemical transport model and an inverse method that includes a growth constraint on emissions. The observations used in the inversion are based on newly measured archived air samples that cover a 39-yr period, from 1973 to 2011, and include 36 Northern Hemispheric and 46 Southern Hemispheric samples. The derived emission estimates show that global emission rates were largest in the 1980s and 1990s for C4F10 and C5F12, and in the 1990s for C6F14, C7F16 and C8F18. After a subsequent decline, emissions have remained relatively stable, within 20%, for the last 5 yr. Bottom-up emission estimates are available from the Emission Database for Global Atmospheric Research version 4.2 (EDGARv4.2) for C4F10, C5F12, C6F14 and C7F16, and inventories of C4F10, C5F12 and C6F14 are reported to the United Nations' Framework Convention on Climate Change (UNFCCC) by Annex 1 countries that have ratified the Kyoto Protocol. The atmospheric measurement-based emission estimates are 20 times larger than EDGARv4.2 for C4F10 and over three orders of magnitude larger for C5F12 (with 2008 EDGARv4.2 estimates for C5F12 at 9.6 kg yr-1, as compared to 67±53 t yr-1 as derived in this study). The derived emission estimates for C6F14 largely agree with the bottom-up estimates from EDGARv4.2. Moreover, the C7F16 emission estimates are comparable to those of EDGARv4.2 at their peak in the 1990s, albeit significant underestimation for the other time periods. There are no bottom-up emission estimates for C8F18, thus the emission rates reported here are the first for C8F18. The reported inventories for C4F10, C5F12 and C6F14 to UNFCCC are five to ten times lower than those

  15. Synthesis and characterization of N, N'-bis[2-hydroxyethyl]-1,4,6,8-naphthalenediimide with para substituted of phenols based on charge-transfer complexes

    NASA Astrophysics Data System (ADS)

    Refat, Moamen S.; Killa, Hamada M. A.; Grabchev, Ivo; El-Sayed, Mohamed Y.

    2007-09-01

    The interaction of charge-transfer (CT) complexes resulted from the reaction of N, N'-bis[2-hydroxyethyl]-1,4,6,8-naphthalenediimide (BHENDI) with some various acceptors like as substituted phenols in para position; 4-aminophenol (4AP), 4-methylphenol (4MP) and 4-nitrophenol (4NP) have been studied in methanol at room temperature. The reaction was studied using electronic (UV-vis), mid infrared, and 1H NMR spectra and thermal measurements (TGA and DTG) as well as elemental analysis CHN. The chemical analysis data of the resulted CT-complexes, BHENDI-acceptors, reveal that the formation of a 1:2 CT complexes in all cases. The interaction of N, N'-bis[2-hydroxyethyl]-1,4,6,8-naphthalenediimide and phenolic acceptors were investigated spectrophotometrically and found two detected CT bands have n-π * transition. The donor site involved in CT interaction is the diimide two nitrogen atoms by forming hydrogen bonding. The kinetic thermodynamic parameters like Δ E, Δ H, Δ S and Δ G are calculated from the DTG diagrams using Coats-Redfern method. The electrical conductivity properties for the solid CT complexes were measured within the temperature of room 25 °C.

  16. (2aR*,5S*,6aS*,8aS*,E)-Ethyl 5-hy­droxy-7,7,8a-trimethyl-8-oxo-2,2a,6,6a,7,8,8a,8b-octa­hydro-1H-penta­leno[1,6-bc]oxepine-4-carboxyl­ate

    PubMed Central

    Mehta, Goverdhan; Kumar, C. S. Ananda; Sen, Saikat

    2012-01-01

    The title compound, C17H24O5, featuring a 2-carbeth­oxy-3-oxepanone unit in its intra­molecularly O—H⋯O hydrogen-bonded enol form, was obtained via [(CF3CO2)2Rh]2-catal­ysed intra­molecular O—H bond insertion in the α-diazo-ω-hy­droxy-β-ketoester, ethyl 4-[(1S,3aS,6R,6aS)-6-hy­droxy-2,2,3a-trimethyl-3-oxo-octa­hydro­penta­len-1-yl]-2-diazo-3-oxobutano­ate. The seven-membered oxacyclic ring, thus constructed on a cis-fused diquinane platform, was found to adopt a distorted boat–sofa conformation. PMID:23476221

  17. Anticonvulsant Activity of Schiff Bases of 3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones

    PubMed Central

    Paneersalvam, P.; Raj, T.; Ishar, M. P. S.; Singh, B.; Sharma, V.; Rather, B. A.

    2010-01-01

    Schiff bases (9a-l) of 3-amino-6,8-dibromo-2-phenyl-quinazolin-4-(3H)-ones (8) with various substituted aldehydes were obtained by refluxing 1:1 molar equivalents of the reactants in dry ethanol for 6 h. The aminoquinazoline (8) was inturn obtained from 3,5-dibromoantharlinic acid via intermediate (7). All the synthesized compounds (9a-l) were evaluated for their anticonvulsant activity on albino mice by maximal electroshock method using phenytoin as a standard. The compound (9l) bearing a cinnamyl function displays a very high activity (82.74 %) at dose level of 100 mg/kg b.w. PMID:21188051

  18. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. [Tetrahydropyrene and hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H[sub 2] hydrogenation reaction network.

  19. Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity

    PubMed Central

    Chen, Yi-Fong; Lin, Yi-Chien; Morris-Natschke, Susan L; Wei, Chen-Fang; Shen, Ting-Chen; Lin, Hui-Yi; Hsu, Mei-Hua; Chou, Li-Chen; Zhao, Yu; Kuo, Sheng-Chu; Lee, Kuo-Hsiung; Huang, Li-Jiau

    2015-01-01

    Background and Purpose 4-Phenylquinolin-2(1H)-one (4-PQ) derivatives can induce cancer cell apoptosis. Additional new 4-PQ analogs were investigated as more effective, less toxic antitumour agents. Experimental Approach Forty-five 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives were synthesized. Antiproliferative activities were evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliun bromide assay and structure–activity relationship correlations were established. Compounds 9b, 9c, 9e and 11e were also evaluated against the National Cancer Institute-60 human cancer cell line panel. Hoechst 33258 and Annexin V-FITC/PI staining assays were used to detect apoptosis, while inhibition of microtubule polymerization was assayed by fluorescence microscopy. Effects on the cell cycle were assessed by flow cytometry and on apoptosis-related proteins (active caspase-3, -8 and -9, procaspase-3, -8, -9, PARP, Bid, Bcl-xL and Bcl-2) by Western blotting. Key Results Nine 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives (7e, 8e, 9b, 9c, 9e, 10c, 10e, 11c and 11e) displayed high potency against HL-60, Hep3B, H460, and COLO 205 cancer cells (IC50 < 1 μM) without affecting Detroit 551 normal human cells (IC50 > 50 μM). Particularly, compound 11e exhibited nanomolar potency against COLO 205 cancer cells. Mechanistic studies indicated that compound 11e disrupted microtubule assembly and induced G2/M arrest, polyploidy and apoptosis via the intrinsic and extrinsic signalling pathways. Activation of JNK could play a role in TRAIL-induced COLO 205 apoptosis. Conclusion and Implications New quinolone derivatives were identified as potential pro-apoptotic agents. Compound 11e could be a promising lead compound for future antitumour agent development. PMID:25363404

  20. Synthesis and Application of 1,3,4,5,7,8-Hexafluorotetracyanonaphthoquinodimethane (F6-TNAP): A Conductivity Dopant for Organic Light-Emitting Devices

    SciTech Connect

    Koech, Phillip K.; Padmaperuma, Asanga B.; Wang, Liang; Swensen, James S.; Polikarpov, Evgueni; Darsell, Jens T.; Rainbolt, James E.; Gaspar, Daniel J.

    2010-07-13

    We report the synthesis, photophysical and organic light-emitting device (OLED) properties of an organic molecular p-dopant 1,3,4,5,7,8-hexafluorotetracyanonaphthoquinodimethane (F6-TNAP). F6-TNAP was obtained in a three step 2 pot synthesis from commercially available octafluoronaphthalene. Doping effect of F6-TNAP was evaluated using films of 1-5% F6-TNAP with N,N'-di-1-naphthyl-N,N'-diphenyl-1,1'-biphenyl-4,4'diamineα-NPD) co-evaporated on quartz. UV-vis analysis of these films showed an absorption peak at 950 nm corresponding to the charge transfer complex resulting from electron transfer from α-NPD to F6-TNAP. Hole only devices using α-NPD as the hole transport layer (HTL) doped with F6-TNAP show greater than 2V decrease in operating voltage compared to the undoped device. A decrease in operating voltage was also demonstrated in blue OLED devices using F6-TNAP doped HTL, with a slight decrease in external quantum efficiency (EQE), thus resulting in a net improvement in power efficiency.

  1. 7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.

    PubMed

    D'Erasmo, Michael P; Smith, William B; Munoz, Alberto; Mohandas, Poornima; Au, Andrew S; Marineau, Jason J; Quadri, Luis E N; Bradner, James E; Murelli, Ryan P

    2014-08-15

    7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic butenolides that can be generated rapidly and as a single diastereomer through a cascade process between γ-hydroxybutenolides and aromatic aldehydes. The following outlines our findings that these spirocycles are potently cytotoxic and have a dramatic structure-function profile that provides excellent insight into the structural features required for this potency.

  2. Global emission estimates and radiative impact of C4F10, C5F12, C6F14, C7F16 and C8F18

    NASA Astrophysics Data System (ADS)

    Ivy, D. J.; Rigby, M.; Baasandorj, M.; Burkholder, J. B.; Prinn, R. G.

    2012-05-01

    Global emission estimates based on new atmospheric observations are presented for the acylic high molecular weight perfluorocarbons (PFCs): decafluorobutane (C4F10), dodecafluoropentane (C5F12), tetradecafluorohexane (C6F14), hexadecafluoroheptane (C7F16) and octadecafluorooctane (C8F18). Emissions are estimated using a 3-dimensional chemical transport model and an inverse method that includes a growth constraint on emissions. The observations used in the inversion are based on newly measured archived air samples that cover a 39-yr period, from 1973 to 2011, and include 36 Northern Hemispheric and 46 Southern Hemispheric samples (Ivy et al., 2012). The derived emission estimates show that global emission rates were largest in the 1980s and 1990s for C4F10 and C5F12, and in the 1990s for C6F14,C7F16 and C8F18. After a subsequent decline, emissions have remained relatively stable, within 20%, for the last 5 yr. Bottom-up emission estimates are available from the Emission Database for Global Atmospheric Research version 4.2 (EDGARv4.2) for C4F10, C5F12, C6F14 and C7F16, and inventories of C4F10, C5F12 andC6F14 are reported to the United Nations' Framework Convention on Climate Change (UNFCCC) by Annex 1 countries that have ratified the Kyoto Protocol. The atmospheric measurement based emission estimates are 20 times larger than EDGARv4.2 for C4F10 and over three orders of magnitude for C5F12. The derived emission estimates for C6F14 largely agree with the bottom-up estimates from EDGARv4.2. Moreover, the C7F16 emission estimates are comparable to those of EDGARv4.2 at their peak in the 1990s, albeit significant underestimation for the other time periods. There are no bottom-up emission estimates for C8F18, thus the emission rates reported here are the first for C8F18. The reported inventories for C4F10, C5F12 and C6F14 to UNFCCC are five to ten times lower than those estimated in this study. In addition, we present measured infrared absorption spectra for C7F16 and C8

  3. Conformational Interconversion of the trans-4-Hydroxynonenal-Derived (6S,8R,11S) 1,N2-Deoxyguanosine Adduct When Mismatched with Deoxyadenosine in DNA

    PubMed Central

    Huang, Hai; Wang, Hao; Lloyd, R. Stephen; Rizzo, Carmelo J.; Stone, Michael P.

    2009-01-01

    The (6S,8R,11S) 1,N2-HNE-dG adduct of trans-4-hydroxynonenal (HNE) was incorporated into the duplex 5′-d(GCTAGCXAGTCC)-3′•5′-d(GGACTAGCTAGC)-3′ [X=(6S,8R,11S) HNE-dG], in which the lesion was mismatched opposite dA. The (6S,8R,11S) adduct maintained the ring-closed 1,N2-HNE-dG structure. This was in contrast to when this adduct was correctly paired with dC, conditions under which it underwent ring opening and re-arrangement to diastereomeric minor groove hemiacetals [Huang, H., Wang, H., Qi, N., Lloyd, R.S., Harris, T.M., Rizzo, C.J., & Stone, M.P. (2008) J. Am. Chem. Soc. 130, 10898–10906]. The (6S,8R,11S) adduct exhibited a syn/anti conformational equilibrium about the glycosyl bond. The syn conformation was predominant in acidic solution. Structural analysis of the syn conformation revealed that X7 formed a distorted base pair with the complementary protonated A18. The HNE moiety was located in the major groove. Structural perturbations were observed at the neighbor C6•G19 and A8•T17 base pairs. At basic pH, the anti conformation of X7 was the major species. At X7 the 1,N2-HNE-dG intercalated and displaced the complementary A18 in the 5′-direction, resulting in a bulge at the X7•A18 base pair. The HNE aliphatic chain was oriented towards the minor groove. The Watson-Crick hydrogen bonding of the neighboring A8•T17 base pair was also disrupted. PMID:19053179

  4. Crystal structure and luminescence properties of Bi3+activated Ca2Y8(SiO4)6O2 phosphors under near UV excitation

    NASA Astrophysics Data System (ADS)

    Sun, Zhihua; Wang, Minqiang; Yang, Zhi; Liu, Kaiping; Zhu, Feiyan

    2016-07-01

    Oxyapatite Ca2Y8-x(SiO4)6O2:xBi3+phosphor has been prepared via high temperature solid-state reaction. Its crystal structure and PL properties were investigated by X-ray diffraction, photoluminescence excitation and emission spectra. The results indicated that the Ca2Y8(SiO4)6O2 crystallizes as a hexagonal structure with a space group of P63/m and lattice constants of a=b=9.3507 Å, c=6.7899 Å, α=β=90.00°, γ=120.00°, V=514.14 Å3; The phosphor has two prominent emission bands: when excited under 320-360 nm, the phosphors emit a broad band centered at 495 nm due to the 3P1-1S0 transition of Bi3+ in 4f (C3) sites; when excited under 380 nm, the phosphors emit a broad band centered at 411 nm due to the 3P1-1S0 transition of Bi3+ in 6h (Cs) sites. The emission color varies from the greenish blue to blue as the excitation wavelength increases from 335 to 380 nm. The optimal intensity of emission band was observed when x=0.015 in the Ca2Y8-x(SiO4)6O2:xBi3+ series. The average critical distance Rc among Bi3+ ions is determined to be 20.15 Å.

  5. Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function

    PubMed Central

    1994-01-01

    To reconstitute the human immune system in mice, transgenic mice expressing human CD4 and human major histocompatibility complex (MHC) class II (DQw6) molecules in an endogenous CD4- and CD8-deficient background (mCD4/8-/-), after homologous recombination, have been generated. We report that expression of human CD4 molecule in mCD4/8-/- mice rescues thymocyte development and completely restores the T cell compartment in peripheral lymphoid organs. Upon vesicular stomatitis virus (VSV) challenge, the reconstituted mature T cell population effectively provide T help to B cells in immunoglobulin class switching from IgM to specific IgG-neutralizing antibodies. Human CD4+DQw6+ double transgenic mice are tolerant to DQw6 and the DQw6 molecule functions in antigen presentation, effectively generating a human MHC class II-restricted T cell response to streptococcal M6C2 peptide. These data show that both the hCD4 and DQw6 molecules are functional in mCD4/8-/- mice, fully and stably reconstituting this limb of the human immune system in mice. This animal model provides a powerful in vivo tool to dissect the human CD4-human class II MHC interaction, especially its role in human autoimmune diseases, superantigen-mediated diseases, and acquired immunodeficiency syndrome (AIDS). PMID:7964466

  6. Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.

    PubMed

    Cronin, J G; Kanamarlapudi, V; Thornton, C A; Sheldon, I M

    2016-09-01

    Interleukin 6 (IL-6), acting via the IL-6 receptor (IL6R) and signal transducer and activator of transcription-3 (STAT3), limits neutrophil recruitment once bacterial infections are resolved. Bovine endometritis is an exemplar mucosal disease, characterized by sustained neutrophil infiltration and elevated IL-6 and IL-8, a neutrophil chemoattractant, following postpartum Gram-negative bacterial infection. The present study examined the impact of the IL6R/STAT3 signaling pathway on IL-8 production by primary endometrial cells in response to short- or long-term exposure to lipopolysaccharide (LPS) from Gram-negative bacteria. Tyrosine phosphorylation of STAT3 is required for DNA binding and expression of specific targets genes. Immunoblotting indicated constitutive tyrosine phosphorylation of STAT3 in endometrial cells was impeded by acute exposure to LPS. After 24 h exposure to LPS, STAT3 returned to a tyrosine phosphorylated state, indicating cross-talk between the Toll-like receptor 4 (TLR4) and the IL6R/STAT3 signaling pathways. This was confirmed by short interfering RNA targeting the IL6R, which abrogated the accumulation of IL-6 and IL-8, induced by LPS. Furthermore, there was a differential endometrial cell response, as the accumulation of IL-6 and IL-8 was dependent on STAT3, suppressor of cytokine signaling 3, and Src kinase signaling in stromal cells, but not epithelial cells. In conclusion, positive feedback through the IL6R amplifies LPS-induced IL-6 and IL-8 production in the endometrium. These findings provide a mechanistic insight into how elevated IL-6 concentrations in the postpartum endometrium during bacterial infection leads to marked and sustained neutrophil infiltration. PMID:26813342

  7. Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells

    PubMed Central

    Cronin, J G; Kanamarlapudi, V; Thornton, C A; Sheldon, I M

    2016-01-01

    Interleukin 6 (IL-6), acting via the IL-6 receptor (IL6R) and signal transducer and activator of transcription-3 (STAT3), limits neutrophil recruitment once bacterial infections are resolved. Bovine endometritis is an exemplar mucosal disease, characterized by sustained neutrophil infiltration and elevated IL-6 and IL-8, a neutrophil chemoattractant, following postpartum Gram-negative bacterial infection. The present study examined the impact of the IL6R/STAT3 signaling pathway on IL-8 production by primary endometrial cells in response to short- or long-term exposure to lipopolysaccharide (LPS) from Gram-negative bacteria. Tyrosine phosphorylation of STAT3 is required for DNA binding and expression of specific targets genes. Immunoblotting indicated constitutive tyrosine phosphorylation of STAT3 in endometrial cells was impeded by acute exposure to LPS. After 24 h exposure to LPS, STAT3 returned to a tyrosine phosphorylated state, indicating cross-talk between the Toll-like receptor 4 (TLR4) and the IL6R/STAT3 signaling pathways. This was confirmed by short interfering RNA targeting the IL6R, which abrogated the accumulation of IL-6 and IL-8, induced by LPS. Furthermore, there was a differential endometrial cell response, as the accumulation of IL-6 and IL-8 was dependent on STAT3, suppressor of cytokine signaling 3, and Src kinase signaling in stromal cells, but not epithelial cells. In conclusion, positive feedback through the IL6R amplifies LPS-induced IL-6 and IL-8 production in the endometrium. These findings provide a mechanistic insight into how elevated IL-6 concentrations in the postpartum endometrium during bacterial infection leads to marked and sustained neutrophil infiltration. PMID:26813342

  8. Evidence for a High-Pressure Phase Transition of ε-2,4,6,8,10,12-hexanitrohexaazaisowurtzitane (CL-20) Using Vibrational Spectroscopy

    SciTech Connect

    Ciezak, J.; Jenkins, T; Liu, Z

    2007-01-01

    The high-pressure response of {epsilon}-2,4,6,8,10,12-hexanitrohexaazaisowurtizane (CL-20) has been examined to 27 GPa in diamond anvil cells using vibrational spectroscopy. The results reveal evidence of an {epsilon}{yields}{Upsilon} pressure-induced phase transition between 4.1 and 6.4 GPa and suggest the existence of a {Upsilon}{yields}{zeta} transition near 18.7 GPa. Several Raman and infrared frequencies were found to decrease in intensity as the phase boundaries are approached. An anomalous intensity increase was noted in the C-N-C infrared mode that is believed to result from an increase in the Raman cross-section due to a stronger interlayer coupling under pressure.

  9. Thermodynamic stability of the molecules YC2, YC3, YC4, YC5, YC6, YC7, and YC8 by high temperature Knudsen effusion mass spectrometry

    NASA Astrophysics Data System (ADS)

    Pelino, Mario; Haque, R.; Bencivenni, L.; Gingerich, K. A.

    1988-05-01

    The molecules YC2, YC3, YC4, YC5, YC6, YC7, and YC8 have been observed in a Knudsen effusion mass spectrometric investigation of the gas phase above the Y-Ir-Au-graphite system. The enthalpies ΔH○0 of the reactions Y(g)+n C(graph)=YCn(g)(n=2-8) were evaluated by the third law method; the second law method was employed for the gaseous molecules with up to six carbon atoms. The selected values of the reaction enthalpies ΔH○0 were combined with ancillary literature data to yield the atomization enthalpies ΔH○a,0 and the standard enthalpies of formation ΔH○f,298.15 in kJ mol-1 of the gaseous yttrium carbides. The values of ΔH○0 and ΔH○a,0 (in kJ mol-1) are 197±5 and 1225±8 for YC2; 377±10 and 1757±12 for YC3; 361±8 and 2484±10 for YC4; 499±10 and 3057±15 for YC5; 536±15 and 3731±20 for YC6; 684±35 and 4294±35 for YC7, and 693±35 and 4727±35 for YC8. The values of ΔH○f,298.15 (in kJ mol-1) are 623±8, 804±12, 790±10, 924±15, 966±20, 1105±35, and 1124±35 for YCn (n=2-8), respectively.

  10. Quantum chemical, ballistic and explosivity calculations on 2,4,6,8-tetranitro-1,3,5,7-tetraaza cyclooctatetraene: a new high energy molecule.

    PubMed

    Gejji, S P; Talawar, M B; Mukundan, T; Kurian, E M

    2006-06-30

    Ab initio molecular orbital calculations have been carried out on 2,4,6,8-tetranitro-1,3,5,7-tetraazacyclooctatetraene, the tetramer of the series (NO(2)CN)(n) where n=1-4, using the Hartree-Fock theory with the 6-31 G(d) basis set. These calculations yield three conformers for the tetramer with D(4h), C(4h) and C(2) symmetries. The nonplanar conformer with the C(2) symmetry turns out to be 99.0 and 164.4kJmol(-1), respectively, lower in energy than the C(4h) and D(4h) conformers. The electron density topography - the density at the bond critical point - has been used as a measure of the CNO(2) strengths. Based on these bond strengths, heats of formation [obtained from the parametric model 3 (PM3) method] and specific decomposition energies, it may be concluded that (NO(2)CN)(4) is a promising candidate in the class of high energy molecules. Theoretically computed explosive (velocity of detonation, detonation pressure, etc.) and ballistic (characteristic velocity, specific impulse, etc.) parameters support these conclusions.

  11. Bromine-rich Zinc Bromides: Zn6Br12(18-crown-6)2×(Br2)5, Zn4Br8(18-crown-6)2×(Br2)3, and Zn6Br12(18-crown-6)2×(Br2)2.

    PubMed

    Hausmann, David; Feldmann, Claus

    2016-06-20

    The bromine-rich zinc bromides Zn6Br12(18-crown-6)2×(Br2)5 (1), Zn4Br8(18-crown-6)2×(Br2)3 (2), and Zn6Br12(18-crown-6)2×(Br2)2 (3) are prepared by reaction of ZnBr2, 18-crown-6, and elemental bromine in the ionic liquid [MeBu3N][N(Tf)2] (N(Tf)2 = bis(trifluoromethylsulfonyl)amide). Zn6Br12(18-crown-6)2×(Br2)5 (1) is formed instantaneously by the reaction. Even at room temperature, compound 1 releases bromine, which was confirmed by thermogravimetry (TG) and mass spectrometry (MS). The release of Br2 can also be directly followed by the color and density of the title compounds. With controlled conditions (2 weeks, 25 °C, absence of excess Br2) Zn6Br12(18-crown-6)2×(Br2)5 (1) slowly releases bromine with conconcurrent generation of Zn4Br8(18-crown-6)2×(Br2)3 (2) (in ionic liquid) and Zn6Br12(18-crown-6)2×(Br2)2 (3) (in inert oil). All bromine-rich zinc bromides contain voluminous uncharged (e.g., Zn3Br6(18-crown-6), Zn2Br4(18-crown-6)) or ionic (e.g., [Zn2Br3(18-crown-6)](+), [(Zn2Br6)×(Br2)2](2-)) building units with dibromine molecules between the Zn oligomers and partially interconnecting the Zn-containing building units. Due to the structural similarity, the bromine release is possible via crystal-to-crystal transformation with retention of the crystal shape. PMID:27281122

  12. Bromine-rich Zinc Bromides: Zn6Br12(18-crown-6)2×(Br2)5, Zn4Br8(18-crown-6)2×(Br2)3, and Zn6Br12(18-crown-6)2×(Br2)2.

    PubMed

    Hausmann, David; Feldmann, Claus

    2016-06-20

    The bromine-rich zinc bromides Zn6Br12(18-crown-6)2×(Br2)5 (1), Zn4Br8(18-crown-6)2×(Br2)3 (2), and Zn6Br12(18-crown-6)2×(Br2)2 (3) are prepared by reaction of ZnBr2, 18-crown-6, and elemental bromine in the ionic liquid [MeBu3N][N(Tf)2] (N(Tf)2 = bis(trifluoromethylsulfonyl)amide). Zn6Br12(18-crown-6)2×(Br2)5 (1) is formed instantaneously by the reaction. Even at room temperature, compound 1 releases bromine, which was confirmed by thermogravimetry (TG) and mass spectrometry (MS). The release of Br2 can also be directly followed by the color and density of the title compounds. With controlled conditions (2 weeks, 25 °C, absence of excess Br2) Zn6Br12(18-crown-6)2×(Br2)5 (1) slowly releases bromine with conconcurrent generation of Zn4Br8(18-crown-6)2×(Br2)3 (2) (in ionic liquid) and Zn6Br12(18-crown-6)2×(Br2)2 (3) (in inert oil). All bromine-rich zinc bromides contain voluminous uncharged (e.g., Zn3Br6(18-crown-6), Zn2Br4(18-crown-6)) or ionic (e.g., [Zn2Br3(18-crown-6)](+), [(Zn2Br6)×(Br2)2](2-)) building units with dibromine molecules between the Zn oligomers and partially interconnecting the Zn-containing building units. Due to the structural similarity, the bromine release is possible via crystal-to-crystal transformation with retention of the crystal shape.

  13. Unexpected ring-closure products derived from 3-(2-allylanilino)-3-phenylacrylate esters: crystal and molecular structures of 3-acetyl-8-allyl-6-methyl-2-phenylquinolin-4-yl acetate and (2RS)-2,8-dimethyl-4-phenyl-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinolin-6-one.

    PubMed

    Luque, Adriana L; Sanabria, Carlos M; Palma, Alirio; Cobo, Justo; Glidewell, Christopher

    2016-08-01

    The reactions of two 3-(2-allylanilino)-3-phenylacrylate esters with acetic anhydride and with strong acids has revealed a richly diverse reactivity providing a number of unexpected products. Thus, acetylation of ethyl 3-(2-allylanilino)-3-phenylacrylate, (Ia), or ethyl 3-(2-allyl-4-methylanilino)-3-phenylacrylate, (Ib), with acetic anhydride yields not only the expected acetylated esters, (II), as the major products but also the unexpected polysubstituted quinolines 3-acetyl-8-allyl-2-phenylquinolin-4-yl acetate, (IIIa), and 3-acetyl-8-allyl-6-methyl-2-phenylquinolin-4-yl acetate, (IIIb), as minor products. Subsequent reaction of the major product ethyl 2-[(2-allyl-4-methylanilino)(phenyl)methylidene]-3-oxobutanoate, (IIb), with concentrated sulfuric acid did not provide the expected 3-acetylquinoline derivative, but instead two unexpected products, namely ethyl 4-ethyl-2-phenyl-1,4-dihydroquinoline-3-carboxylate, (IV), and ethyl 3-acetyl-4-ethyl-2-phenyl-3,4-dihydroquinoline-3-carboxylate, (V), in yields of 39 and 22%, respectively. The reaction of (Ib) with Eaton's reagent gave both the quinoline (Z)-6-methyl-2-phenyl-8-(prop-1-en-1-yl)quinolin-4(1H)-one, (VI), and the unexpected tricyclic product (2RS)-2,8-dimethyl-4-phenyl-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinolin-6-one, (VII), in yields of 71 and 12%, respectively. The products (II)-(VII) have all been fully characterized spectroscopically and the crystal structures of two of the unexpected products, i.e. (IIIb) (C23H21NO3) and (VII) (C19H17NO), are reported here. The formation of compounds (IV), (V) and (VII) all require an isomerization of the initial allyl substituent, with migration of the C=C double bond from the terminal site to the internal site. In (IIIb), the two acetyl substituents are oriented such that the intramolecular distance between the two carbonyl O atoms is only 3.243 (2) Å, and in (VII), the five-membered ring adopts a twisted half-chair conformation. The molecules of compound (IIIb

  14. Warm Spitzer Secondary Transit Photometry of Hot Jupiters HAT-P-6b, HAT-P-8b and XO-4b

    NASA Astrophysics Data System (ADS)

    Todorov, Kamen 0.; Deming, D.; Knutson, H.; Burrows, A.; Sada, P.; Agol, E.; Desert, J.; Fortney, J. J.; Charbonneau, D.; Cowan, N. B.; Laughlin, G.; Langton, J.; Showman, A. P.; Lewis, N. K.

    2011-05-01

    An increasing number of transiting exoplanets have been observed at secondary eclipse. By measuring the depth of these eclipses at different wavelengths it is possible to distinguish between planets that have a temperature inversion in the upper layers of their atmospheres and ones that do not. We observed XO-4b, HAT-P-6b and HAT-P-8b during secondary eclipse with the IRAC instrument on Warm Spitzer at 3.6 and 4.5 microns. We compare the resulting eclipse depths to atmospheric models with and without temperature inversions, and thereby place constraints on the properties of their day-side atmospheres and heat redistribution efficiencies. The XO-4b and HAT-P-6b eclipse depths agree best with inverted models, while HAT-P-8b exhibits no temperature inversion. Knutson et al. (2010) hypothesized a correlation between lack of a temperature inversion and host star activity. Also, Cowan & Agol (2011), investigated the dependence between planetary effective temperatures, assuming no redistribution, and heat redistribution efficiency, finding that the hottest planets re-distribute heat inefficiently. We compare our planets with the Knutson and Cowan-Agol relations, and we find that they are consistent with the Knutson et al. activity hypothesis, but they are not hot enough to test the Cowan & Agol hypothesis.

  15. Spectroscopic characterization of the isolated SF6- and C4F8- anions: observation of very long harmonic progressions in symmetric deformation modes upon photodetachment.

    PubMed

    Bopp, Joseph C; Roscioli, Joseph R; Johnson, Mark A; Miller, Thomas M; Viggiano, A A; Villano, Stephanie M; Wren, Scott W; Lineberger, W Carl

    2007-02-22

    Spectroscopic studies of the SF6- and c-C4F8- anions are reported to provide experimental benchmarks for theoretical predictions of their structures and electron binding energies. The photoelectron spectrum of SF6- is dominated by a long progression in the S-F stretching mode, with an envelope consistent with theoretical predictions that the anion preserves the Oh symmetry of the neutral, but has a longer S-F bond length. This main progression occurs with an unexpectedly strong contribution from a second mode, however, whose characteristic energy does not correspond to any of the neutral SF6 fundamental vibrations in its ground electronic state. The resulting doublet pattern is evident when the bare ion is prepared with low internal energy content (i.e., using N2 carrier gas in a free jet or liquid nitrogen-cooling in a flowing afterglow) but is much better resolved in the spectrum of the SF6-.Ar complex. The infrared predissociation spectrum of SF6-.Ar consists of a strong band at 683(5) cm(-1), which we assign to the nu3 (t1u) fundamental, the same mode that yields the strong 948 cm(-1) infrared transition in neutral SF6. One qualitatively interesting aspect of the SF6- behavior is the simple structure of its photoelectron spectrum, which displays uncluttered, harmonic bands in an energy region where the neutral molecule contains about 2 eV of vibrational excitation. We explore this effect further in the c-C4F8- anion, which also presents a system that is calculated to undergo large, symmetrical distortion upon electron attachment to the neutral. The photoelectron spectrum of this species is dominated by a long, single vibrational progression, this time involving the symmetric ring-breathing mode. Like the SF6- case, the c-C4F8- spectrum is remarkably isolated and harmonic in spite of the significant internal excitation of a relatively complex molecular framework. Both these perfluorinated anions thus share the property that the symmetrical deformation of the

  16. SUPERSTARS III: 6-8.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Education, Raleigh.

    SUPERSTARS III is a K-8 program designed as an enrichment opportunity for self-directed learners in mathematics. The basic purpose of SUPERSTARS III is to provide the extra challenge that self-motivated students need in mathematics and to do so in a structured, long-term program that does not impinge on the normal classroom routine or the…

  17. (9E)-9-benzylidene-2-methylsulfanyl-5-phenyl-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one: a hydrogen-bonded R2(2)(8) dimer.

    PubMed

    Becerra, Diana; Insuasty, Braulio; Cobo, Justo; Glidewell, Christopher

    2013-12-15

    In the molecule of the title compound, C25H21N3OS, which was prepared by mild oxidation of the corresponding 5,6,7,8,9,10-hexahydro analogue, the fused carbocyclic ring adopts an envelope conformation. Pairs of molecules are linked into cyclic centrosymmetric dimers by pairs of inversion-related N-H···O hydrogen bonds.

  18. 2-(3,5-Dioxo-4-aza­tri­cyclo­[5.2.1.02,6]dec-8-en-4-yl)acetic acid

    PubMed Central

    Akkurt, Mehmet; Jarrahpour, Aliasghar; Shirvani, Pouria; Tahir, Muhammad Nawaz

    2013-01-01

    The asymmetric unit of the title compound, C11H11NO4, contains two mol­ecules, A and B, with different conformations: in mol­ecule A, the norborne and carb­oxy­lic acid groups lie to the same side of the heterocycle, whereas in a mol­ecule B, they lie on opposite sides. In the crystal, the A mol­ecules form R 2 2(8) carb­oxy­lic acid inversion dimers, linked by pairs of O—H⋯O hydrogen bonds. The B mol­ecules link to one of the ketone O atoms of the A mol­ecule by an O—H⋯O inter­action, resulting in tetra­mers (two A and two B mol­ecules). The tetra­mers are linked by weak C—H⋯O inter­actions, generating a three-dimensional network. PMID:24427042

  19. Theoretical study of the structures and first hyperpolarizabilities of C60Cl n and Li@C60Cl n (n = 4, 6, 8, 10).

    PubMed

    Song, Yao-Dong; Wang, Liang; Wu, Li-Ming

    2016-06-01

    We recently reported (Song Y-D et al., 2016, J Mol Model 22:50) that doping with Li greatly affects the static first hyperpolarizability of C60Cl2. In this work, with a view to creating nonlinear optical materials with high thermodynamic stability and wide transparent regions, a series of Li@C60Cl n (n = 4, 6, 8, 10) were designed. The structures, electrostatic potentials, electronic structures, absorption spectra, and linear and nonlinear optical properties of C60Cl n and Li@C60Cl n were systematically investigated using density functional theory (DFT) methods. The results of our calculations indicated that the stability of these molecules decreases in the order Li@C60Cl10 > Li@C60Cl8 > Li@C60Cl6 > Li@C60Cl4. It is clear that the number of Cl atoms greatly influences the stability of Li@C60Cl n . Li@C60Cl n showed greater thermodynamic stability than Li@C60Cl2. We also investigated the first hyperpolarizabilities of Li@C60Cl n and found them to be 2973, 3640, 4307, and 2627 au for n = 4, 6, 8, and 10, respectively-higher than that of Li@C60Cl2. Finally, we noted that the transparent region could be modulated by increasing the number of Cl atoms: Li@C60Cl n possess wider transparent regions than that of Li@C60Cl2. We therefore believe that this study has highlighted an effective method for designing nonlinear optical materials with high thermodynamic stability and wide transparent regions. PMID:27188724

  20. 2,5-Diphenyl-2,5,6,8-tetra­hydro-1,2,4-triazolo[3,4-c][1,4]oxazin-4-ium hexa­fluorido­phosphate

    PubMed Central

    Wu, Jie; Wei, Siping; Liu, Bo; Wang, Wenhai; Lan, Jingbo

    2008-01-01

    The title compound, C17H16N3O+·PF6 −, is a chiral bicyclic 1,2,4-triazolium salt. In the crystal packing, C—H⋯O and C—H⋯F hydrogen bonds and P—F⋯π contacts [4.078 (11)–4.163 (11) Å, involving the triazolium ring] play an important role in enhancing the stability of the crystal structure. PMID:21203295

  1. Regioselective synthesis of 2,8-disubstituted 4-aminopyrido[3,2-d]pyrimidine-6-carboxylic acid methyl ester compounds.

    PubMed

    Bouscary-Desforges, Gwenaelle; Bombrun, Agnes; Augustine, John Kallikat; Bernardinelli, Gérald; Quattropani, Anna

    2012-01-01

    We report herein the synthesis of 4-amino-2,8-dichloropyrido[3,2-d]pyrimidine derivatives 2 and their regioselective diversification through S(N)Ar and metal-catalyzed cross-coupling reactions. While amination of 2 took place selectively at C-2, the regioselectivity of thiol or thiolate addition depended on the reaction conditions. Selective C-8 addition was obtained in DMF with Hünig's base and C-2 addition in (i)PrOH. These C-2 or C-8 regioselective thiolations provided an opportunistic way to selectively activate either of the two positions toward the metal-catalyzed cross-coupling reaction. The chloride could be efficiently substituted by Suzuki-Miyaura reaction and the sulfanyl group by Liebeskind-Srogl cross-coupling reaction, demonstrating the orthogonality of both reactive centers. The development of regioselective conditions for these different transformations yielded the synthesis of 4-amino-2,6,8-trisubstituted pyrido[3,2-d]pyrimidine derivatives, with various substituents.

  2. Volumetric Properties of the Mixture Oxolane C4H8O + C6H10O Cyclohexanone (VMSD1111, LB3912_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Oxolane C4H8O + C6H10O Cyclohexanone (VMSD1111, LB3912_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  3. Volumetric Properties of the Mixture Oxolane C4H8O + C6H10O Cyclohexanone (VMSD1212, LB3919_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Oxolane C4H8O + C6H10O Cyclohexanone (VMSD1212, LB3919_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  4. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1111, LB4821_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1111, LB4821_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  5. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1511, LB4830_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1511, LB4830_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  6. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1212, LB4825_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1212, LB4825_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  7. Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1511, LB5121_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1511, LB5121_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  8. Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1111, LB5124_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1111, LB5124_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  9. Heat of Mixing and Solution of 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (HMSD1111, LB4308_H)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Heat of Mixing and Solution of 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (HMSD1111, LB4308_H)' providing data from direct low-pressure calorimetric measurement of molar excess enthalpy at variable mole fraction and constant temperature.

  10. Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1212, LB5126_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1212, LB5126_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  11. Optimized anisotropic magnetoelectric response of Fe61.6Co16.4Si10.8B11.2/PVDF/Fe61.6Co16.4Si10.8B11.2 laminates for AC/DC magnetic field sensing

    NASA Astrophysics Data System (ADS)

    Reis, S.; Silva, M. P.; Castro, N.; Correia, V.; Gutierrez, J.; Lasheras, A.; Lanceros-Mendez, S.; Martins, P.

    2016-05-01

    The anisotropic magnetoelectric (ME) effect on a Fe61.6Co16.4Si10.8B11.2/PVDF Fe61.6Co16.4Si10.8B11.2 laminate composite has been used for the development of a magnetic field sensor able to detect both the magnitude and direction of AC and DC magnetic fields. The accuracy (99% for both AC and DC sensors), linearity (92% for the DC sensor and 99% for the AC sensor) and reproducibility (99% for both sensors) indicate the suitability of the sensor for applications. Furthermore, the sensitivity of the Fe61.6Co16.4Si10.8B11.2/PVDF/Fe61.6Co16.4Si10.8B11.2 anisotropic magnetic sensor—15 and 1400 mV Oe-1 for the DC and AC fields, respectively—are the highest reported in the literature for polymer-based ME materials. Such features, combined with its flexibility, versatility, light weight, low cost and low-temperature fabrication, lead to the suitability of the developed sensor for use in magnetic sensor applications.

  12. 24 CFR 8.6 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Communications. 8.6 Section 8.6... URBAN DEVELOPMENT General Provisions § 8.6 Communications. (a) The recipient shall take appropriate steps to ensure effective communication with applicants, beneficiaries, and members of the public....

  13. 24 CFR 8.6 - Communications.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Communications. 8.6 Section 8.6... URBAN DEVELOPMENT General Provisions § 8.6 Communications. (a) The recipient shall take appropriate steps to ensure effective communication with applicants, beneficiaries, and members of the public....

  14. 24 CFR 8.6 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Communications. 8.6 Section 8.6... URBAN DEVELOPMENT General Provisions § 8.6 Communications. (a) The recipient shall take appropriate steps to ensure effective communication with applicants, beneficiaries, and members of the public....

  15. 24 CFR 8.6 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Communications. 8.6 Section 8.6... URBAN DEVELOPMENT General Provisions § 8.6 Communications. (a) The recipient shall take appropriate steps to ensure effective communication with applicants, beneficiaries, and members of the public....

  16. 24 CFR 8.6 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Communications. 8.6 Section 8.6... URBAN DEVELOPMENT General Provisions § 8.6 Communications. (a) The recipient shall take appropriate steps to ensure effective communication with applicants, beneficiaries, and members of the public....

  17. Low Power Resistive Oxygen Sensor Based on Sonochemical SrTi0.6Fe0.4O2.8 (STFO40).

    PubMed

    Stratulat, Alisa; Serban, Bogdan-Catalin; de Luca, Andrea; Avramescu, Viorel; Cobianu, Cornel; Brezeanu, Mihai; Buiu, Octavian; Diamandescu, Lucian; Feder, Marcel; Ali, Syed Zeeshan; Udrea, Florin

    2015-01-01

    The current paper reports on a sonochemical synthesis method for manufacturing nanostructured (typical grain size of 50 nm) SrTi0.6Fe0.4O2.8 (Sono-STFO40) powder. This powder is characterized using X ray-diffraction (XRD), Mössbauer spectroscopy and Scanning Electron Microscopy (SEM), and results are compared with commercially available SrTi0.4Fe0.6O2.8 (STFO60) powder. In order to manufacture resistive oxygen sensors, both Sono-STFO40 and STFO60 are deposited, by dip-pen nanolithography (DPN) method, on an SOI (Silicon-on-Insulator) micro-hotplate, employing a tungsten heater embedded within a dielectric membrane. Oxygen detection tests are performed in both dry (RH = 0%) and humid (RH = 60%) nitrogen atmosphere, varying oxygen concentrations between 1% and 16% (v/v), at a constant heater temperature of 650 °C. The oxygen sensor, based on the Sono-STFO40 sensing layer, shows good sensitivity, low power consumption (80 mW), and short response time (25 s). These performance are comparable to those exhibited by state-of-the-art O2 sensors based on STFO60, thus proving Sono-STFO40 to be a material suitable for oxygen detection in harsh environments. PMID:26205267

  18. Low Power Resistive Oxygen Sensor Based on Sonochemical SrTi0.6Fe0.4O2.8 (STFO40)

    PubMed Central

    Stratulat, Alisa; Serban, Bogdan-Catalin; de Luca, Andrea; Avramescu, Viorel; Cobianu, Cornel; Brezeanu, Mihai; Buiu, Octavian; Diamandescu, Lucian; Feder, Marcel; Ali, Syed Zeeshan; Udrea, Florin

    2015-01-01

    The current paper reports on a sonochemical synthesis method for manufacturing nanostructured (typical grain size of 50 nm) SrTi0.6Fe0.4O2.8 (Sono-STFO40) powder. This powder is characterized using X ray-diffraction (XRD), Mössbauer spectroscopy and Scanning Electron Microscopy (SEM), and results are compared with commercially available SrTi0.4Fe0.6O2.8 (STFO60) powder. In order to manufacture resistive oxygen sensors, both Sono-STFO40 and STFO60 are deposited, by dip-pen nanolithography (DPN) method, on an SOI (Silicon-on-Insulator) micro-hotplate, employing a tungsten heater embedded within a dielectric membrane. Oxygen detection tests are performed in both dry (RH = 0%) and humid (RH = 60%) nitrogen atmosphere, varying oxygen concentrations between 1% and 16% (v/v), at a constant heater temperature of 650 °C. The oxygen sensor, based on the Sono-STFO40 sensing layer, shows good sensitivity, low power consumption (80 mW), and short response time (25 s). These performance are comparable to those exhibited by state-of-the-art O2 sensors based on STFO60, thus proving Sono-STFO40 to be a material suitable for oxygen detection in harsh environments. PMID:26205267

  19. Suppression of Adipogenesis by 5-Hydroxy-3,6,7,8,3',4'-Hexamethoxyflavone from Orange Peel in 3T3-L1 Cells.

    PubMed

    Wang, Yu; Lee, Pei-Sheng; Chen, Yi-Fen; Ho, Chi-Tang; Pan, Min-Hsiung

    2016-09-01

    We reported previously that hydroxylated polymethoxyflavones (HPMFs) effectively suppressed obesity in high-fat-induced mouse. In this study, we further investigated the molecular mechanism of action of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF), one of major HPMFs in orange peel. Treatment of 5-OH-HxMF effectively inhibited lipid accumulation by 55-60% in a dose-dependent manner. The 5-OH-HxMF attenuated adipogenesis through downregulating adipogenesis-related transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding proteins (C/EBPs), as well as downstream target fatty acid synthase and acetyl-CoA carboxylase (ACC). 5-OH-HxMF activated adenosine monophosphate-activated protein kinase signaling and silent mating type information regulation 1 (SIRTUIN 1 or SIRT1) in 3T3-L1 adipocytes to decrease lipid accumulation. In addition, the inhibition rate of lipid accumulation was compared between 5-OH-HxMF and 3,5,6,7,8,3',4'-heptamethoxyflavone (HpMF). 5-OH-HxMF inhibited lipid accumulation 15-20% more than HpMF did, indicating that hydroxyl group at position 5 can be a key factor in the suppression of adipogenesis. PMID:27542074

  20. Assembly of 4-, 6- and 8-connected Cd(II) pseudo-polymorphic coordination polymers: Synthesis, solvent-dependent structural variation and properties

    NASA Astrophysics Data System (ADS)

    Li, Zhao-Hao; Xue, Li-Ping; Miao, Shao-Bin; Zhao, Bang-Tun

    2016-08-01

    The reaction of Cd(NO3)2·4H2O, 2,5-thiophenedicarboxylic acid (H2tdc) and 1,2-bis(imidazol-1‧-yl)methane (bimm) by modulating solvent systems yielded three highly connected pseudo-polymorphic coordination polymers based on different dinuclear [Cd2(CO2)2] subunits bridged by carboxylate groups. Single crystal structural analyses reveal structural variation from 4-connected 2D sql layer, 6-connected 2-fold interpenetrated 3D pcu to 8-connected 3D bcu-type network in compounds 1-3. The structural dissimilarity in the structures dependent on the coordination environments of Cd(II) ions and linking modes of mixed ligand influenced by different solvent systems during the synthesis process. Moreover, thermogravimetric and photoluminescence behaviors of 1-3 were also investigated for the first time, and all the complexes emit blue luminescence in the solid state.

  1. Pump-probe photoelectron velocity-map imaging of autoionizing singly excited 4s{sup 1}4p{sup 6}np{sup 1}(n=7,8) and doubly excited 4s{sup 2}4p{sup 4}5s{sup 1}6p{sup 1} resonances in atomic krypton

    SciTech Connect

    Doughty, Benjamin; Haber, Louis H.; Leone, Stephen R.

    2011-10-15

    Pump-probe photoelectron velocity-map imaging, using 27-eV high-harmonic excitation and 786-nm ionization, is used to resolve overlapping autoionizing resonances in atomic krypton, obtaining two-photon photoelectron angular distributions (PADs) for singly and doubly excited states. Two features in the photoelectron spectrum are assigned to singly excited 4s{sup 1}4p{sup 6}np{sup 1} (n = 7,8) configurations and four features provide information about double excitation configurations. The anisotropy parameters for the singly excited 7p configuration are measured to be {beta}{sub 2} = 1.61 {+-} 0.06 and {beta}{sub 4} = 1.54 {+-} 0.16 while the 8p configuration gives {beta}{sub 2} = 1.23 {+-} 0.19 and {beta}{sub 4} = 0.60 {+-} 0.15. These anisotropies most likely represent the sum of overlapping PADs from states of singlet and triplet spin multiplicities. Of the four bands corresponding to ionization of doubly excited states, two are assigned to 4s{sup 2}4p{sup 4}5s{sup 1}6p{sup 1} configurations that are probed to different J-split ion states. The two remaining doubly excited states are attributed to a previously observed, but unassigned, resonance in the vacuum-ultraviolet photoabsorption spectrum. The PADs from each of the double excitation states are also influenced by overlap from neighboring states that are not completely spectrally resolved. The anisotropies of the observed double excitation states are reported, anticipating future theoretical and experimental work to separate the overlapping PADs into the state resolved PADs. The results can be used to test theories of excited state ionization.

  2. The Monte Carlo event generator AcerMC versions 2.0 to 3.8 with interfaces to PYTHIA 6.4, HERWIG 6.5 and ARIADNE 4.1

    NASA Astrophysics Data System (ADS)

    Kersevan, Borut Paul; Richter-Waş, Elzbieta

    2013-03-01

    parton density functions. Provided is also a set of control processes: qq¯→W→ℓν; qq¯→Z/γ∗→ℓℓ; gg,qq¯→tt¯ and gg→(tt¯→)WbWb¯; Reasons for new version: Implementation of several new processes and methods. Summary of revisions: Each version added new processes or functionalities, a detailed list is given in the section “Changes since AcerMC 1.0”. Restrictions: The package is optimised for the 14 TeV pp collision simulated in the LHC environment and also works at the achieved LHC energies of 7 TeV and 8 TeV. The consistency between results of the complete generation using PYTHIA 6.4 or HERWIG 6.5 interfaces is technically limited by the different approaches taken in both these generators for evaluating αQCD and αQED couplings and by the different models for fragmentation/hadronisation. For the consistency check, in the AcerMC library contains native coded definitions of the QCD and αQED. Using these native definitions leads to the same total cross-sections both with PYTHIA 6.4 or HERWIG 6.5 interfaces.

  3. 2-Amino-4-(4-meth­oxy­phen­yl)-5-oxo-5,6,7,8-tetra­hydro-4H-chromene-3-carbonitrile 1,4-dioxane hemisolvate

    PubMed Central

    Mohamed, Shaaban K.; Akkurt, Mehmet; Tahir, Muhammad N.; Abdelhamid, Antar A.; Younes, Sabry H. H.

    2012-01-01

    In the crystal structure of the title compound, C17H16N2O3·0.5C4H8O2, pairs of N—H⋯N hydrogen bonds link mol­ecules into dimers with R 2 2(12) motifs, which are connected by N—H⋯O hydrogen bonds, forming a supra­molecular array in the ab plane. The 1,4-dioxane ring, which lies about an inversion center, adopts a chair conformation. PMID:22798847

  4. [The neuroprotective action of enantiomers and racemate of 2-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)-4-methylthiobutanoic acid].

    PubMed

    Kravchenko, A N; Baranov, V V; Anikina, L V; Vikharev, Iu B; Bushmarinov, I S; Neliubina, Iu V

    2012-01-01

    Neurotropic, neuroprotective and antioxidant actions of the enantiomers and the racemate of 2-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)-4-methylthiobutanoic acid were investigated. Only (+)-(S)-2-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)-4-methylthiobutanoic acid was found to have neuroprotective properties. A distereoselective synthesis of enantiomers and racemate was performed by condensations of (S), (R) and (R,S)-N-carbamoylmethionines with 4,5-dihydroxyimidazolidin-2-one (DHI), respectively. By the X-ray method, the major racemate was proved to crystallize from water as a conglomerate. No antioxidant activity was revealed.

  5. Theoretical study of isoelectronic molecules: B6H10, 2-CB5H9, 2,3-C2B4H8, 2,3,4-C3B3H7, and 2,3,4,5-C4B2H6.

    PubMed

    Tian, Shan Xi

    2005-07-28

    Isoelectronic molecules regarding B6H10, 2-CB5H9, 2,3-C2B4H8, 2,3,4-C3B3H7, and 2,3,4,5-C4B2H6 are studied by the density functional B3LYP/6-311G(d,p) method and the electron propagator theory in the partial third-order quasiparticale approximation, as well as the extrapolated calculation with the coupled-cluster CCSD(T) theory. The calculated ionization potentials are in good agreement with the experimental data from photoelectron spectroscopy. Valence structures are characterized with natural orbital bond (NBO) theory, exhibiting the multiple three-center two-electron bonds B-H-B, B-B-B, C-B-B, B-C-B, and C-B-C, and chemical bond rearrangements in the cations. PMID:16834005

  6. Murine CD8(+)T cell cytotoxicity against schistosomula induced by inoculation of schistosomal 22.6/26GST coupled Sepharose 4B beads.

    PubMed

    Zhou, Ying; Zhang, Hui; Sun, Xin-Juan; Zheng, Dan; Liang, Yue-Jin; Luo, Jie; Wang, Yong; Zhang, Zhao-Song

    2012-03-23

    Schistosomasis is a world-wide parasitic disease. Although chemotherapy is the main treatment method for schistosomasis currently, it cannot prevent schistosome reinfection. Up to now no effective vaccine is available to prevent schistosomiasis. Dendritic cells (DCs) are one of the key players in the cellular immune response and play an important role in antigen presentation as antigen-presenting cells. Here we reported a novel large particulate antigen, in which Sepharose 4B beads were coated with Sj22.6/26GST. Our results showed that this particulate antigen could be cross-presented by DCs to CD8(+)T cells. Furthermore, CD8(+)T cells stimulated by particulate antigen directly exerted cytotoxicity against Schistosoma japonicum schistosomula. We also demonstrated that S. japonicum schistosomula acquired the MHC class I molecules from host blood serum and presented the molecules at the larval surface. While it may help them escape from the host immune surveillance, these MHC I-antigen complexes presented on the surface render schistosomula the potential targets of the CD8(+)T cell cytotoxicity induced by particulate antigen-based vaccine. Finally we evaluated the protective immunity of this particulate vaccine in a mouse infection challenge model. Our data clearly showed that the particulate vaccine induced a partial reduction in both worm burdens and egg loads. Taken together, these results suggest that this large particulate vaccine could be a potential vaccine for the prevention of schistosome infection.

  7. Design, fabrication, and performance of brazed, graphite electrode, multistage depressed collectors with 500-W, continuous wave, 4.8- to 9.6-GHz traveling-wave tubes

    NASA Technical Reports Server (NTRS)

    Ramins, Peter; Ebihara, Ben

    1989-01-01

    A small, isotropic graphite electrode, multistage depressed collector (MDC) was designed, fabricated, and evaluated in conjunction with a 500-W, continuous wave (CW), 4.8- to 9.6-GHz traveling-wave tube (TWT). The carbon electrode surfaces were used to improve the TWT overall efficiency by minimizing the secondary electron emission losses in the MDC. The design and fabrication of the brazed graphite MDC assembly are described. The brazing technique, which used copper braze filler metal, is compatible with both vacuum and the more commonly available hydrogen atmosphere brazing furnaces. The TWT and graphite electrode MCC bakeout, processing, and outgassing characteristics were evaluated and found to be comparable to TWT's equipped with copper electrode MDC's. The TWT and MDC performance was optimized for broadband CW operation at saturation. The average radiofrequency (RF), overall, and MDC efficiencies were 14.9, 46.4, and 83.6 percent, respectively, across the octave operating band. A 1500-hr CW test, conducted without the use of an appendage ion pump, showed no gas buildup and excellent stability of the electrode surfaces.

  8. Thermal reactions of uranium metal, UO 2, U 3O 8, UF 4, and UO 2F 2 with NF 3 to produce UF 6

    NASA Astrophysics Data System (ADS)

    McNamara, Bruce; Scheele, Randall; Kozelisky, Anne; Edwards, Matthew

    2009-11-01

    This paper demonstrates that NF 3 fluorinates uranium metal, UO 2, UF 4, UO 3, U 3O 8, and UO 2F 2·2H 2O to produce the volatile UF 6 at temperatures between 100 and 550 °C. Thermogravimetric and differential thermal analysis reaction profiles are described that reflect changes in the uranium fluorination/oxidation state, physiochemical effects, and instances of discrete chemical speciation. Large differences in the onset temperatures for each system investigated implicate changes in mode of the NF 3 gas-solid surface interaction. These studies also demonstrate that NF 3 is a potential replacement fluorinating agent in the existing nuclear fuel cycle and in actinide volatility reprocessing.

  9. Development of Ti-6Al-4V and Ti-1Al-8V-5Fe Alloys Using Low-Cost TiH2 Powder Feedstock

    SciTech Connect

    Joshi, Vineet V.; Lavender, Curt; Moxon, Vladimir; Duz, Vlad; Nyberg, Eric; Weil, K. Scott

    2012-09-25

    Thermo-mechanical processing was performed on two titanium alloy billets, a beta-titanium alloy (Ti1Al8V5Fe) and an alpha-beta titanium alloy (Ti6Al4V), which had been produced using a novel low-cost powder metallurgy process that relies on the use of TiH2 powder as a feedstock material. The thermomechanical processing was performed in the beta region of the respective alloys to form 16-mm diameter bars. The hot working followed by the heat treatment processes not only eliminated the porosity within the materials but also developed the preferred microstructures. Tensile testing and rotating beam fatigue tests were conducted on the as-rolled and heat-treated materials to evaluate their mechanical properties. The mechanical properties of these alloys matched well with those produced by the conventional ingot processing route.

  10. Final analysis of proton form factor ratio data at Q2 = 4.0, 4.8, and 5.6 GeV2

    DOE PAGES

    Puckett, A. J. R.; Brash, E. J.; Gayou, O.; Jones, M. K.; Pentchev, L.; Perdrisat, C. F.; Punjabi, V.; Aniol, K. A.; Averett, T.; Benmokhtar, F.; et al

    2012-04-11

    Recently published measurements of the proton electromagnetic form factor ratio R = μp GEp/GMp at momentum transfers Q2 up to 8.5 GeV2 in Jefferson Lab Hall C deviate from the linear trend of previous measurements in Jefferson Lab Hall A, favoring a slower rate of decrease of R with Q2. While statistically compatible in the region of overlap with Hall A, the Hall C data hint at a systematic difference between the two experiments. This possibility was investigated in a reanalysis of the Hall A data. We find that the original analysis underestimated the background in the selection of elasticmore » events. The application of an additional cut to further suppress the background increases the results for R, improving the consistency between Halls A and C.« less

  11. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  12. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  13. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  14. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  15. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  16. Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

    PubMed

    Press, Neil J; Taylor, Roger J; Fullerton, Joseph D; Tranter, Pamela; McCarthy, Clive; Keller, Thomas H; Arnold, Nicola; Beer, David; Brown, Lyndon; Cheung, Robert; Christie, Julie; Denholm, Alastair; Haberthuer, Sandra; Hatto, Julia D I; Keenan, Mark; Mercer, Mark K; Oakman, Helen; Sahri, Helene; Tuffnell, Andrew R; Tweed, Morris; Trifilieff, Alexandre

    2015-09-10

    Herein we describe the optimization of a series of PDE4 inhibitors, with special focus on solubility and pharamcokinetics, to clinical compound 2, 4-(8-(3-fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic acid. Although compound 2 produces emesis in humans when given as a single dose, its exemplary pharmacokinetic properties enabled a novel dosing regime comprising multiple escalating doses and the resultant achievement of high plasma drug levels without associated nausea or emesis. PMID:26288344

  17. Studies of (Cs,Ba)-hollandite dissolution under gamma irradiation at 95 °C and at pH 2.5, 4.4 and 8.6

    NASA Astrophysics Data System (ADS)

    Suzuki-Muresan, T.; Vandenborre, J.; Abdelouas, A.; Grambow, B.; Utsunomiya, S.

    2011-12-01

    In the frame of the former French 1991-law on waste management, which was extended in 2006-law, hollandite ceramic was studied as a potential specific conditioning matrix for caesium isotopes (long-life radionuclide 135Cs and the strong heat generating radionuclide 137Cs). In this general study of Cs-containment in a ceramic matrix, the chemical durability was pointed out as a key property. Leaching experiments in static mode were conducted during 240 days at various pH-values from acidic to alkaline range. The initial leaching rates between 0 and 45 days are faster for Cs than for Ba and the average for the caesium are (1.4 ± 0.1) × 10 -4 g/m 2/d (pH 2.5), (6.4 ± 0.9) × 10 -5 g/m 2/d (pH 4.4) and (3.1 ± 0.6) × 10 -5 g/m 2/d (pH 8.6), and for the barium (6 ± 1) × 10 -5 g/m 2/d (pH 2.5), (2.8 ± 0.3) × 10 -5 g/m 2/d (pH 4.4), and (2 ± 2) × 10 -6 g/m 2/d (pH 8.6). At the equilibrium between 45 and 240 days, the normalised mass losses average for caesium are (8.2 ± 0.3) × 10 -3 g/m 2 (pH 2.5), (5.2 ± 0.4) × 10 -3 g/m 2 (pH 4.4) and (4.1 ± 0.2) × 10 -3 g/m 2 (pH 8.6), and for barium (3.7 ± 0.4) × 10 -3 g/m 2 (pH 2.5), (2.0 ± 0.1) × 10 -3 g/m 2 (pH 4.4) and (4 ± 2) × 10 -4 g/m 2 (pH 8.6). Caesium and barium are incongruently released in solution with a correlation slope close to 0.5 at pH 2.5 and pH 4.4 and very low (near 0.02) in alkaline solution. Sorption experiments with radioactive isotopes ( 137Cs and 133Ba) were conducted on hollandite pre-leached in aqueous solutions. Caesium and barium release is controlled by the surface reactions. Leaching experiments and isotopic addition experiments ( 137Cs- and 133Ba-radiotracer) indicate that caesium behaviour is independent on pH-values, whereas barium behaviour is strongly dependent. Additional experiments in the presence of gamma irradiation ( 60Co source) did not show any significant effect on hollandite leaching process.

  18. Fine Structures of 8-G-1-(p-YC6H4C ≡ CSe)C10H6 (G = H, Cl, and Br) in Crystals and Solutions: Ethynyl Influence and Y- and G-Dependences

    PubMed Central

    Hayashi, Satoko; Yamane, Kentaro; Nakanishi, Waro

    2009-01-01

    Fine structures of 8-G-1-(p-YC6H4C ≡ CSe)C10H6 [1 (G = H) and 2 (G = Cl): Y = H (a), OMe (b), Me (c), F (d), Cl (e), CN (f), and NO2 (g)] are determined by the X-ray analysis. Structures of 1, 2, and 3 (G = Br) are called A if each Se–Csp bond is perpendicular to the naphthyl plane, whereas they are B when the bond is placed on the plane. Structures are observed as A for 1a–c bearing Y of nonacceptors, whereas they are B for 1e–g with Y of strong acceptors. The change in the structures of 1e–g versus those of 1a–c is called Y-dependence in 1. The Y-dependence is very specific in 1 relative to 1-(p-YC6H4Se)C10H7 (4) due to the ethynyl group: the Y-dependence in 1 is almost inverse to the case of 4 due to the ethynyl group. We call the specific effect “Ethynyl Influence.” Structures of 2 are observed as B: the A-type structure of 1b changes dramatically to B of 2b by G = Cl at the 8-position, which is called G-dependence. The structures of 2 and 3 are examined in solutions based on the NMR parameters. PMID:19809512

  19. 2-[6,8-Dibromo-3-(4-hy­droxy­cyclo­hex­yl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]phenol methanol 0.25-solvate

    PubMed Central

    Wang, Zhi-Gang; Wang, Rong; Zhi, Feng; Wang, Ming-Li

    2011-01-01

    The title compound, C20H22Br2N2O2·0.25CH4O, was synthesized by the condensation reaction of salicyl­aldehyde with 4-(2-amino-3,5-dibromo­benzyl­amino)­cyclo­hexa­nol in methanol. There are four independent main mol­ecules and two half-occupied methanol solvent mol­ecules in the asymmetric unit. The dihedral angles between the two benzene rings in the four mol­ecules are 87.8 (6), 86.6 (6), 89.3 (6) and 83.1 (6)°. Each mol­ecule features an intra­molecular O—H⋯N hydrogen bond and a short N—H⋯Br link. In the crystal components are linked by O—H⋯O hydrogen bonds. PMID:21754095

  20. Final analysis of proton form factor ratio data at Q2=4.0, 4.8, and 5.6 GeV2

    NASA Astrophysics Data System (ADS)

    Puckett, A. J. R.; Brash, E. J.; Gayou, O.; Jones, M. K.; Pentchev, L.; Perdrisat, C. F.; Punjabi, V.; Aniol, K. A.; Averett, T.; Benmokhtar, F.; Bertozzi, W.; Bimbot, L.; Calarco, J. R.; Cavata, C.; Chai, Z.; Chang, C.-C.; Chang, T.; Chen, J. P.; Chudakov, E.; De Leo, R.; Dieterich, S.; Endres, R.; Epstein, M. B.; Escoffier, S.; Fissum, K. G.; Fonvieille, H.; Frullani, S.; Gao, J.; Garibaldi, F.; Gilad, S.; Gilman, R.; Glamazdin, A.; Glashausser, C.; Gomez, J.; Hansen, J.-O.; Higinbotham, D.; Huber, G. M.; Iodice, M.; de Jager, C. W.; Jiang, X.; Khandaker, M.; Kozlov, S.; Kramer, K. M.; Kumbartzki, G.; LeRose, J. J.; Lhuillier, D.; Lindgren, R. A.; Liyanage, N.; Lolos, G. J.; Margaziotis, D. J.; Marie, F.; Markowitz, P.; McCormick, K.; Michaels, R.; Milbrath, B. D.; Nanda, S. K.; Neyret, D.; Piskunov, N. M.; Ransome, R. D.; Raue, B. A.; Roché, R.; Rvachev, M.; Salgado, C.; Sirca, S.; Sitnik, I.; Strauch, S.; Todor, L.; Tomasi-Gustafsson, E.; Urciuoli, G. M.; Voskanyan, H.; Wijesooriya, K.; Wojtsekhowski, B. B.; Zheng, X.; Zhu, L.

    2012-04-01

    Precise measurements of the proton electromagnetic form factor ratio R=μpGEp/GMp using the polarization transfer method at Jefferson Lab have revolutionized the understanding of nucleon structure by revealing the strong decrease of R with momentum transfer Q2 for Q2≳1 GeV2, in strong disagreement with previous extractions of R from cross-section measurements. In particular, the polarization transfer results have exposed the limits of applicability of the one-photon-exchange approximation and highlighted the role of quark orbital angular momentum in the nucleon structure. The GEp-II experiment in Jefferson Lab's Hall A measured R at four Q2 values in the range 3.5GeV2≤Q2≤5.6GeV2. A possible discrepancy between the originally published GEp-II results and more recent measurements at higher Q2 motivated a new analysis of the GEp-II data. This article presents the final results of the GEp-II experiment, including details of the new analysis, an expanded description of the apparatus, and an overview of theoretical progress since the original publication. The key result of the final analysis is a systematic increase in the results for R, improving the consistency of the polarization transfer data in the high-Q2 region. This increase is the result of an improved selection of elastic events which largely removes the systematic effect of the inelastic contamination, underestimated by the original analysis.

  1. Modelling the role of electron attachment rates on column density ratios for C n H‑/C n H (n=4,6,8) in dense molecular clouds

    NASA Astrophysics Data System (ADS)

    Gianturco, F. A.; Grassi, T.; Wester, R.

    2016-10-01

    The fairly recent detection of a variety of anions in the interstellar molecular clouds have underlined the importance of realistically modelling the processes governing their abundance. To pursue this task, our earlier calculations for the radiative electron attachment (REA) rates for C4H‑, C6H‑, and C8H‑ are employed in the present work, within a broad network of other concurrent reactions, to generate the corresponding column density ratios of anion/neutral (A/N) relative abundances. The latter are then compared with those obtained in recent years from observational measurements. The calculations involved the time-dependent solutions of a large network of chemical processes over an extended time interval and included a series of runs in which the values of REA rates were repeatedly scaled over several orders of magnitude. Macroscopic parameters for the Clouds’ modelling were also varied to cover a broad range of physical environments. It was found that, within the range and quality of the processes included in the present network,and selected from state-of-the-art astrophysical databases, the REA values required to match the observed A/N ratios needed to be reduced by orders of magnitude for C4H‑ case, while the same rates for C6H‑ and C8H‑ only needed to be scaled by much smaller factors. The results suggest that the generally proposed formation of interstellar anions by REA mechanism is overestimated by current models for the C4H‑ case, for which is likely to be an inefficient path to formation. This path is thus providing a rather marginal contribution to the observed abundances of C4H‑, the latter being more likely to originate from other chemical processes in the network, as we discuss in some detail in the present work. Possible physical reasons for the much smaller differences against observations found instead for the values of the (A/N) ratios in two other, longer members of the series are put forward and analysed within the

  2. Low temperature rate coefficients for reactions of the butadiynyl radical, C4H, with various hydrocarbons. Part I: reactions with alkanes (CH4, C2H6, C3H8, C4H10).

    PubMed

    Berteloite, Coralie; Le Picard, Sébastien D; Balucani, Nadia; Canosa, André; Sims, Ian R

    2010-04-21

    The kinetics of the reactions of the linear butadiynyl radical, C4H (CCCCH), with methane, ethane, propane and butane have been studied over the temperature range of 39-300 K using a CRESU (Cinétique de Réaction en Ecoulement Supersonique Uniforme or Reaction Kinetics in Uniform Supersonic Flow) apparatus combined with the pulsed laser photolysis-laser induced fluorescence technique. The rate coefficients, except for the reaction with methane, show a negative temperature dependence and can be fitted with the following expressions over the temperature range of this study: k(C2H6) = 0.289 x 10(-10) (T/298 K)(-1.23) exp(-24.8 K/T) cm3 molecule(-1) s(-1); k(C3H8) = 1.06 x 10(-10) (T/298 K)(-1.36) exp(-56.9 K/T) cm3 molecule(-1) s(-1); k(C4H10) = 2.93 x 10(-10) (T/298 K)(-1.30) exp(-90.1 K/T) cm3 molecule(-1) s(-1). The rate coefficients for the reaction with methane were measured only at 200 K and 300 K yielding a positive temperature dependence: k(CH4) = 1.63 x 10(-11) exp(-610 K/T) cm3 molecule(-1) s(-1). Possible reaction mechanisms and product channels are discussed in detail for each of these reactions. Potential implications of these results for models of low temperature chemical environments, in particular cold interstellar clouds and planetary atmospheres such as that of Titan, are considered.

  3. New 7-arylpiperazinylalkyl-8-morpholin-4-yl-purine-2,6-dione derivatives with anxiolytic activity - Synthesis, crystal structure and structure-activity study

    NASA Astrophysics Data System (ADS)

    Chłoń-Rzepa, Grażyna; Żmudzki, Paweł; Pawłowski, Maciej; Wesołowska, Anna; Satała, Grzegorz; Bojarski, Andrzej J.; Jabłoński, Mateusz; Kalinowska-Tłuścik, Justyna

    2014-06-01

    On the basis of our earlier studies with serotonin (5-HT) receptor ligands in the group of long-chain arylpiperazines (LCAPs), a new series of 7-arylpiperazinylalkyl-8-morpholin-4-yl-purine-2,6-dione derivatives (5-12) has been designed, synthesised and studied in vitro for their affinity for 5-HT1A, 5-HT2A, 5-HT6 and 5-HT7 receptors. The introduction of o-OCH3 and m-Cl into the phenylpiperazinyl moiety as well as the elongation of the linker between purine-2,6-dione core and arylpiperazine fragment modified the affinity for the tested 5-HT receptors. The structures of compounds 9-11 (hydrochloride salts) were confirmed by an X-ray diffraction method. All molecules adopted a different conformation in the crystal. The strongest observed type of interaction is a charge assisted hydrogen bond N+-H⋯Cl-. Additionally, the π-π interactions between 1,3-dimethyl-3,7-dihydropurine-2,6-dione cores of the neighbouring molecules were also observed. As it is observed in the presented crystal structures, the morpholine ring (a potential donor and acceptor of the hydrogen bonds) seems to be an attractive substituent, that may support binding to the non-specific sites of 5-HT receptors. Another interesting feature is the mutual orientation of rings in the arylpiperazine fragment, with plausible influence on ligand-receptor recognition. For compound 10, with strong 5-HT1A binding affinity, the mutual orientation of rings is determined by the intramolecular weak C-H⋯O hydrogen bond. This observation may contribute to a better understanding of the more selective binding of o-OCH3 arylpiperazine derivatives to the 5-HT1A receptor.

  4. Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions.

    PubMed

    Kemnitzer, William; Kasibhatla, Shailaja; Jiang, Songchun; Zhang, Hong; Zhao, Jianghong; Jia, Shaojuan; Xu, Lifen; Crogan-Grundy, Candace; Denis, Réal; Barriault, Nancy; Vaillancourt, Louis; Charron, Sylvie; Dodd, Jennifer; Attardo, Giorgio; Labrecque, Denis; Lamothe, Serge; Gourdeau, Henriette; Tseng, Ben; Drewe, John; Cai, Sui Xiong

    2005-11-01

    As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the SAR of 4-aryl-4H-chromenes with modifications at the 7- and 5-, 6-, 8-positions. It was found that a small hydrophobic group, such as NMe2, NH2, NHEt, and OMe, is preferred at the 7-position. Di-substitution at either the 5,7-positions or the 6,7-positions generally led to a large decrease in potency. Di-substitution at the 7,8-positions, in general, was found to result in potent compounds. 7-NMe2, 7-NHEt, 7-OMe, and 7,8-di-NH2 analogs were found to have similar SAR for the 4-aryl group, and several 7-substituted and 7,8-di-substituted analogs were found to have similar potencies as the lead compound MX58151 (2a) both as caspase activators and inhibitors of cell proliferation.

  5. Synthesis and structural studies of a new class of quaternary ammonium salts, which are derivatives of cage adamanzane type aminal 1, 3, 6, 8-tetraazatricyclo[4.3.1.13,8]undecane (TATU)

    PubMed Central

    2011-01-01

    Background Novel mono N-alkyl quaternary ammonium salts (3a-f) were prepared using the Menschutkin reaction from the cage adamanzane type aminal 1,3,6,8-tetraazatricyclo[4.3.1.13,8]undecane (TATU) and alkyl iodides, such as methyl, ethyl, propyl, butyl, pentyl and hexyl iodide (2a-f), in dry acetonitrile at room temperature. Results The structures of these new quaternary ammonium salts were established using various spectral and electrospray ionization mass spectrometry (ESI-MS) analyses. Compound (3b) was also analyzed using X-ray crystallography. Conclusion It was noted that alkyl chain length did not significantly affect the reaction because all employed alkyl iodide electrophiles reacted in a similar fashion with the aminal 1 to produce the corresponding mono N-quaternary ammonium salts, which were characterized by spectroscopic and analytical techniques. PMID:21933409

  6. We are Family: the Conformations of 1-FLUOROALKANES, C_nH2n+1F (n = 2,3,4,5,6,7,8)

    NASA Astrophysics Data System (ADS)

    Obenchain, Daniel A.; Orellana, W.; Cooke, S. A.

    2016-06-01

    he pure rotational spectra of the n = 5, 6, 7, and 8 members of the 1-fluoroalkane family have been recorded between 7 GHz and 14 GHz using chirped pulse Fourier transform microwave spectroscopy. The spectra have been analyzed and results will be presented and compared with previous work on the n= 2, 3, and 4 members. The lowest energy conformer for all family members has the common feature that the fluorine is in a gauche position relative to the alkyl tail for which all other heavy atom dihedral angles, where appropriate, are 180 degrees. For the n = 3 and higher family members the second lowest energy conformer has all heavy atom dihedral angles equal to 180 degrees. For each family member transitions carried by both low energy conformers were observed in the collected rotational spectra. Quantum chemical calculations were performed and trends in the energy separations between these two common conformers will be presented as a function of chain length. Furthermore, longer chain lengths have been examined using only quantum chemical calculations and results will be presented. M. Hayashi, M. Fujitake, T. Inagusa, S. Miyazaki, J.Mol.Struct., 216, 9-26, 1990 W. Caminati, A. C. Fantoni, F. Manescalchi, F. Scappini, Mol.Phys., 64, 1089 ,1988 L. B. Favero, A. Maris, A. Degli Esposti, P. G. Favero, W. Caminati, G. Pawelke, Chem.Eur.J., 6(16), 3018-3025, 2000

  7. Spatial element distribution control in a fully solution-processed nanocrystals-based 8.6% Cu2ZnSn(S,Se)4 device.

    PubMed

    Hsu, Wan-Ching; Zhou, Huanping; Luo, Song; Song, Tze-Bin; Hsieh, Yao-Tsung; Duan, Hsin-Sheng; Ye, Shenglin; Yang, Wenbing; Hsu, Chia-Jung; Jiang, Chengyang; Bob, Brion; Yang, Yang

    2014-09-23

    A fully solution-processed high performance Cu2ZnSn(S,Se)4 (CZTSSe, kesterite) device has been demonstrated. It is based on the rational engineering of elemental spatial distributions in the bulk and particularly near the surface of the film from nanocrystal precursors. The nanocrystals are synthesized through a modified colloidal approach, with excellent solubility over a large compositional window, followed by a selenization process to form the absorber. The X-ray photoluminescence (XPS) depth profiling indicates an undesirable Sn-rich surface of the selenized film. An excessive Zn species was quantitatively introduced through nanocrystals precursor to correct the element distribution, and accordingly a positive correlation between the spatial composition in the bulk/surface film and the resulting device parameter is established. The enhanced device performance is associated with the reduced interfacial recombination. With a Zn content 1.6 times more than the stoichiometry; the optimized device, which is fabricated by employing a full solution process from the absorber to the transparent top electrode, demonstrates a performance of 8.6%. This composition-control approach through stoichiometric adjustments of nanocrystal precursors, and the developed correlation between the spatial composition and device performance may also benefit other multielement-based photovoltaics. PMID:25106060

  8. A new insight into high-strength Ti62Nb12.2Fe13.6Co6.4Al5.8 alloys with bimodal microstructure fabricated by semi-solid sintering.

    PubMed

    Liu, L H; Yang, C; Kang, L M; Qu, S G; Li, X Q; Zhang, W W; Chen, W P; Li, Y Y; Li, P J; Zhang, L C

    2016-03-31

    It is well known that semi-solid forming could only obtain coarse-grained microstructure in a few alloy systems with a low melting point, such as aluminum and magnesium alloys. This work presents that semi-solid forming could also produce novel bimodal microstructure composed of nanostructured matrix and micro-sized (CoFe)Ti2 twins in a titanium alloy, Ti62Nb12.2Fe13.6Co6.4Al5.8. The semi-solid sintering induced by eutectic transformation to form a bimodal microstructure in Ti62Nb12.2Fe13.6Co6.4Al5.8 alloy is a fundamentally different approach from other known methods. The fabricated alloy exhibits high yield strength of 1790 MPa and plastic strain of 15.5%. The novel idea provides a new insight into obtaining nano-grain or bimodal microstructure in alloy systems with high melting point by semi-solid forming and into fabricating high-performance metallic alloys in structural applications.

  9. A new insight into high-strength Ti62Nb12.2Fe13.6Co6.4Al5.8 alloys with bimodal microstructure fabricated by semi-solid sintering

    NASA Astrophysics Data System (ADS)

    Liu, L. H.; Yang, C.; Kang, L. M.; Qu, S. G.; Li, X. Q.; Zhang, W. W.; Chen, W. P.; Li, Y. Y.; Li, P. J.; Zhang, L. C.

    2016-03-01

    It is well known that semi-solid forming could only obtain coarse-grained microstructure in a few alloy systems with a low melting point, such as aluminum and magnesium alloys. This work presents that semi-solid forming could also produce novel bimodal microstructure composed of nanostructured matrix and micro-sized (CoFe)Ti2 twins in a titanium alloy, Ti62Nb12.2Fe13.6Co6.4Al5.8. The semi-solid sintering induced by eutectic transformation to form a bimodal microstructure in Ti62Nb12.2Fe13.6Co6.4Al5.8 alloy is a fundamentally different approach from other known methods. The fabricated alloy exhibits high yield strength of 1790 MPa and plastic strain of 15.5%. The novel idea provides a new insight into obtaining nano-grain or bimodal microstructure in alloy systems with high melting point by semi-solid forming and into fabricating high-performance metallic alloys in structural applications.

  10. A new insight into high-strength Ti62Nb12.2Fe13.6Co6.4Al5.8 alloys with bimodal microstructure fabricated by semi-solid sintering

    PubMed Central

    Liu, L. H.; Yang, C.; Kang, L. M.; Qu, S. G.; Li, X. Q.; Zhang, W. W.; Chen, W. P.; Li, Y. Y.; Li, P. J.; Zhang, L. C.

    2016-01-01

    It is well known that semi-solid forming could only obtain coarse-grained microstructure in a few alloy systems with a low melting point, such as aluminum and magnesium alloys. This work presents that semi-solid forming could also produce novel bimodal microstructure composed of nanostructured matrix and micro-sized (CoFe)Ti2 twins in a titanium alloy, Ti62Nb12.2Fe13.6Co6.4Al5.8. The semi-solid sintering induced by eutectic transformation to form a bimodal microstructure in Ti62Nb12.2Fe13.6Co6.4Al5.8 alloy is a fundamentally different approach from other known methods. The fabricated alloy exhibits high yield strength of 1790 MPa and plastic strain of 15.5%. The novel idea provides a new insight into obtaining nano-grain or bimodal microstructure in alloy systems with high melting point by semi-solid forming and into fabricating high-performance metallic alloys in structural applications. PMID:27029858

  11. Development and Binding Mode Assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid (BGC 945), a Novel Thymidylate Synthase Inhibitor that Targets Tumor Cells

    PubMed Central

    Tochowicz, Anna; Dalziel, Sean; Eidam, Oliv; O’Connell, Joseph D.; Griner, Sarah; Finer-Moore, Janet S.; Stroud, Robert M.

    2013-01-01

    N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid 1 (BGC 945, now known as ONX 0801), is a small molecule thymidylate synthase (TS) inhibitor discovered at the Institute of Cancer Research in London. It is licensed by Onyx Pharmaceuticals and is in Phase 1 clinical studies. It is a novel antifolate drug resembling TS inhibitors plevitrexed and raltitrexed that combines enzymatic inhibition of thymidylate synthase with α-folate receptor-mediated targeting of tumor cells. Thus, it has potential for efficacy with lower toxicity due to selective intracellular accumulation through α-folate receptor (α-FR) transport. The α-FR, a cell-surface receptor glycoprotein, which is over expressed mainly in ovarian and lung cancer tumors, has an affinity for 1 similar to that for its natural ligand, folic acid. This study describes a novel synthesis of 1, an X-ray crystal structure of its complex with Escherichia coli TS and 2’-deoxyuridine-5’-monophosphate, and a model for a similar complex with human TS. PMID:23710599

  12. A novel technique for measurement of thermal rate constants and temperature dependences of dissociative recombination: CO2(+), CF3(+), N2O(+), C7H8(+), C7H7(+), C6H6(+), C6H5(+), C5H6(+), C4H4(+), and C3H3(+).

    PubMed

    Fournier, Joseph A; Shuman, Nicholas S; Melko, Joshua J; Ard, Shaun G; Viggiano, Albert A

    2013-04-21

    A novel technique using a flowing afterglow-Langmuir probe apparatus for measurement of temperature dependences of rate constants for dissociative recombination (DR) is presented. Low (~10(11) cm(-3)) concentrations of a neutral precursor are added to a noble gas∕electron afterglow plasma thermalized at 300-500 K. Charge exchange yields one or many cation species, each of which may undergo DR. Relative ion concentrations are monitored at a fixed reaction time while the initial plasma density is varied between 10(9) and 10(10) cm(-3). Modeling of the decrease in concentration of each cation relative to the non-recombining noble gas cation yields the rate constant for DR. The technique is applied to several species (O2(+), CO2(+), CF3(+), N2O(+)) with previously determined 300 K values, showing excellent agreement. The measurements of those species are extended to 500 K, with good agreement to literature values where they exist. Measurements are also made for a range of CnHm(+) (C7H7(+), C7H8(+), C5H6(+), C4H4(+), C6H5(+), C3H3(+), and C6H6(+)) derived from benzene and toluene neutral precursors. CnHm(+) DR rate constants vary from 8-12 × 10(-7) cm(3) s(-1) at 300 K with temperature dependences of approximately T(-0.7). Where prior measurements exist these results are in agreement, with the exception of C3H3(+) where the present results disagree with a previously reported flat temperature dependence. PMID:23614415

  13. A Study on the Base–Catalyzed Reverse Vinylogous Aldol Reaction of (4aβ,5β)-4,4a,5,6,7,8-Hexahydro-5-hydroxy-1,4a-dimethylnaphthalen-2(3H)-one under Robinson Annulation Conditions

    PubMed Central

    Payette, Joshua N.; Honda, Tadashi; Yoshizawa, Hidenori; Favaloro, Frank G.; Gribble, Gordon W.

    2008-01-01

    We have proposed a pathway of the base–catalyzed reverse vinylogous aldol reaction of (−)-(4aβ,5β)-4,4a,5,6,7,8-hexahydro-5-hydroxy-1,4a-dimethylnaphthalen-2(3H)-one ((−)-8) under Robinson annulation conditions. For confirmation, 4-(2,6-dimethyl-3-oxocyclohex-1-enyl)butanal (11) and 4-(2,6-dimethyl-5-oxocyclohex-1-enyl)butanal (12), both of which potentially produce enolate I, were synthesized regioselectively. Unexpectedly, 11 gave a complex mixture including only a trace amount of (±)-8 (less than 5% yield) under these basic conditions. To the contrary, 12 cleanly afforded (±)-8 in 66% yield. This result provides evidence for our proposed mechanism of the above reaction. PMID:16388674

  14. Umbra Ver. 4.8

    SciTech Connect

    Oppel, III, Fred; Hart, Brian; Hart, Derek; Linebarger, John; Rigdon, J. Brian; Wolfenbarger, Paul; Xavier, Patrick; & Gottlieb, Eric

    2010-02-24

    Umbra is a software package that has been in development at Sandia National Laboratories since 1995, under the name Umbra since 1997. Umbra is a software framework written in C++ and Tcl/Tk that has been applied to many operations, primarily dealing with robotics and simulation. Umbra executables are C++ libraries orchestrated with Tcl/Tk scripts. Two major feature upgrades occurred from 4.7 to 4.8 1. System Umbra Module with its own Update Graph within the C++ framework. 2. New terrain graph for fast line-of-sight calculations All else were minor updates such as later versions of Visual Studio, OpenSceneGraph and Boost.

  15. 8 CFR 103.6 - Surety bonds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Surety bonds. 103.6 Section 103.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees § 103.6...

  16. 8 CFR 103.6 - Surety bonds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Surety bonds. 103.6 Section 103.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees § 103.6...

  17. 8 CFR 103.6 - Surety bonds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Surety bonds. 103.6 Section 103.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees § 103.6...

  18. Formation of a Vitamin C Conjugate of Acrolein and its Paraoxonase-mediated Conversion into 5,6,7,8-Tetrahydroxy-4-oxooctanal

    PubMed Central

    Kesinger, Nicholas G.; Langsdorf, Brandi L.; Yokochi, Alexandre F.; Miranda, Cristobal L.; Stevens, Jan F.

    2010-01-01

    Vitamin C (ascorbic acid) has been reported to participate in Michael addition reactions in vitro to form vitamin C conjugates with α,β-unsaturated aldehydes, such as acrolein. This study shows evidence for the formation and metabolism of the vitamin C conjugate of acrolein (AscACR) in cultured human monocytic THP-1 cells exposed to acrolein diacetate. By using 18O and 13C labeling in combination with liquid chromatography–tandem mass spectrometry, AscACR was shown to undergo hydrolytic conversion of the ascorbyl lactone into an intermediate carboxylic acid. Subsequent decarboxylation of the carboxylic acid yielded 5,6,7,8-tetrahydroxy-4-oxooctanal (THO). When THP-1 cells were pretreated with ascorbic acid (1 mM, 18 hours) and then exposed to acrolein diacetate, THO was detected as its pentafluorobenzyl oxime derivative in the cell lysates and medium. Treatment of THP-1 cells with both ascorbic acid and acrolein diacetate was required for THO formation. The formation of THO from AscACR was facilitated by the lactonase enzymes, human recombinant paraoxonases 1 and 2. THP-1 cells exhibited PON activity which explains the catalytic conversion of AscACR into THO in these cells. THO was formed in addition to metabolites of the glutathione conjugate of acrolein, indicating that THO formation contributes to the elimination of acrolein in a cellular environment. PMID:20353174

  19. Dissociation of molecular chlorine in a Coulomb explosion: Potential curves, bound states, and deviation from Coulombic behavior for Cln+2 (n=2,3,4,6,8,10)

    NASA Astrophysics Data System (ADS)

    Wright, J. S.; Dilabio, G. A.; Matusek, D. R.; Corkum, P. B.; Ivanov, M. Yu.; Ellert, Ch.; Buenker, R. J.; Alekseyev, A. B.; Hirsch, G.

    1999-06-01

    Highly charged molecular ions are generated in Coulomb explosion experiments involving multielectron dissociative ionization, but little is known about the precise mechanisms involved in their formation. To help improve the understanding of such experiments, potential energy curves are calculated in this paper for diatomic chlorine (Cl2) and its ions Cln+2, where n=1,2,3,4,6,8,10. Bound vibrational states are obtained in three low-lying electronic states for Cl2+2 and one state for Cl3+2. Vertical excitation energies are given for stepwise excitations up to Cl10+2. For all the ions examined there is a significant energy defect (Δ) from the corresponding Coulomb potential, in one case reaching magnitudes of over 20 eV. We analyze the origin of these energy defects in terms of residual chemical bonding, and discuss the contribution of strongly bonding configurations at short internuclear distance. Finally, we present a simple physical model which describes the qualitative behavior of Δ(R,Q).

  20. Solvation effects on reactive intermediates: The benzyl radical and its clusters with Ar, N2, CH4, C2H6, and C3H8

    NASA Astrophysics Data System (ADS)

    Disselkamp, R.; Bernstein, E. R.

    1993-03-01

    Mass resolved excitation spectra are presented for the benzyl radical and its clusters with Ar, N2, CH4, C2H6, and C3H8. The cluster spectra exhibit small redshifts (≤50 cm-1) relative to the unclustered benzyl radical for the D1(1 2A2)←D0(1 2B2) and D2(2 2B2)←D0(1 2B2) electronic transition regions. A unique set of low energy van der Waals modes is observed for these clusters for each excited electronic state investigated. The cluster spectra also reveal significant vibronic coupling between the two excited electronic states of the benzyl radical, as evidenced by a single vibrational predissociation threshold for each cluster. Ab initio calculations are performed on the benzyl radical to examine excited electronic state structure, predict transition energies, estimate ionization energy, and determine partial atomic charges in the electronic states of interest. The resulting partial charges are used in empirical atom-atom potential energy calculations to aid in the understanding of cluster spectroscopic shifts, binding energies, and van der Waals modes.

  1. Spectral characteristics of nanoamorphous phosphors obtained by evaporation of Sr2Gd8(SiO4)6O2: Eu polycrystals

    NASA Astrophysics Data System (ADS)

    Zuev, M. G.; Sokovnin, S. Yu.; Il'ves, V. G.; Baklanova, I. V.; Vasin, A. A.

    2014-10-01

    Amorphous nanophosphors have been obtained for the first time by pulsed electron beam evaporation of targets from bulk polycrystalline phosphors of the composition Sr2Gd8(SiO4)6O2: Eu with oxyapatite structure. The processes of crystallization of amorphous nanopowder were studied using differential scanning calorimetry and termogravimetry (40-1400 °C). It was found that the Raman spectra of the samples are modified when the particles decrease from bulk to nanodimensional state. The spectral and luminescent characteristics of the phosphors in polycrystalline and nanoamorphous states have been examined. It was established that Eu3+ forms two types of optical centers. Unlike bulk phosphors, in the nanophosphors no Eu2+ ions are formed. The ratio of red to orange luminescence intensity for nanophosphors was found to increase as compared with bulk phosphors. This effect is due to disordering of nanoparticles. A resonant transfer of excitation energy from Gd3+ to Eu3+ ions was found in bulk and nanophosphors. Upon transition from polycrystalline to nanoamorphous state and laser excitation of phosphors, the luminescence intensity of Eu3+ ions increases approximately 10 times. This effect is explained in the framework of the configuration coordinates model.

  2. REDSHIFT 6.4 HOST GALAXIES OF 10{sup 8} SOLAR MASS BLACK HOLES: LOW STAR FORMATION RATE AND DYNAMICAL MASS

    SciTech Connect

    Willott, Chris J.; Omont, Alain; Bergeron, Jacqueline

    2013-06-10

    We present Atacama Large Millimeter Array observations of rest-frame far-infrared continuum and [C II] line emission in two z = 6.4 quasars with black hole masses of Almost-Equal-To 10{sup 8} M{sub Sun }. CFHQS J0210-0456 is detected in the continuum with a 1.2 mm flux of 120 {+-} 35 {mu}Jy, whereas CFHQS J2329-0301 is undetected at a similar noise level. J2329-0301 has a star formation rate limit of <40 M{sub Sun} yr{sup -1}, considerably below the typical value at all redshifts for this bolometric luminosity. Through comparison with hydro simulations, we speculate that this quasar is observed at a relatively rare phase where quasar feedback has effectively shut down star formation in the host galaxy. [C II] emission is also detected only in J0210-0456. The ratio of [C II] to far-infrared luminosity is similar to that of low-redshift galaxies of comparable luminosity, suggesting that the previous finding of an offset in the relationships between this ratio and far-infrared luminosity at low and high redshifts may be partially due to a selection effect due to the limited sensitivity of previous continuum data. The [C II] line of J0210-0456 is relatively narrow (FWHM = 189 {+-} 18 km s{sup -1}), indicating a dynamical mass substantially lower than expected from the local black hole-velocity dispersion correlation. The [C II] line is marginally resolved at 0.''7 resolution with the blue and red wings spatially offset by 0.''5 (3 kpc) and a smooth velocity gradient of 100 km s{sup -1} across a scale of 6 kpc, possibly due to the rotation of a galaxy-wide disk. These observations are consistent with the idea that stellar mass growth lags black hole accretion for quasars at this epoch with respect to more recent times.

  3. Influence of crystal characteristics on the shock sensitivities of cyclotrimethylene trinitramine, cyclotetramethylene tetranitramine, and 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetra-cyclo[5,5,0,03,1105,9]dodecane immersed in liquid

    NASA Astrophysics Data System (ADS)

    Li, Hongzhen; Xu, Rong; Kang, Bing; Li, Jinshan; Zhou, Xiaoqing; Zhang, Chaoyang; Nie, Fude

    2013-05-01

    The shock sensitivities of differently qualified cyclotrimethylene trinitramine (RDX), cyclotetramethylene tetranitramine(HMX), and 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetra-cyclo[5,5,0,03,1105,9]dodecane (CL-20) immersed in liquid were determined by the large-scale gap tests, for systemic discussion on the influences of crystal characteristics on them. As a result, it shows that (1) the immersion of crystals in liquid leads to an obvious sensitivity decrease; (2) for all three explosives, their shock sensitivities are lowered with increasing their crystal apparent densities or decreasing their particle sizes, and almost not affected by particle morphologies; (3) the crystal twins are readily formed for HMX and the most distinct factor influencing its shock sensitivities; (4) it is found that the crystal apparent density affects most obviously the shock sensitivities for RDX and CL-20; and (5) CL-20, HMX, and RDX are less and less sensitive to shock, suggesting chemical components are also a determining factor.

  4. Quasi-three-coordinate iron and cobalt terphenoxide complexes {Ar(iPr8)OM(μ-O)}2 (Ar(iPr8) = C6H-2,6-(C6H2-2,4,6-(i)Pr3)2-3,5-(i)Pr2; M = Fe or Co) with M(III)2(μ-O)2 core structures and the peroxide dimer of 2-oxepinoxy relevant to benzene oxidation.

    PubMed

    Zhao, Pei; Lei, Hao; Ni, Chengbao; Guo, Jing-Dong; Kamali, Saeed; Fettinger, James C; Grandjean, Fernande; Long, Gary J; Nagase, Shigeru; Power, Philip P

    2015-09-21

    The bis(μ-oxo) dimeric complexes {Ar(iPr8)OM(μ-O)}2 (Ar(iPr8) = C6H-2,6-(C6H2-2,4,6-(i)Pr3)2-3,5-(i)Pr2; M = Fe (1), Co (2)) were prepared by oxidation of the M(I) half-sandwich complexes {Ar(iPr8)M(η(6)-arene)} (arene = benzene or toluene). Iron species 1 was prepared by reacting {Ar(iPr8)Fe(η(6)-benzene)} with N2O or O2, and cobalt species 2 was prepared by reacting {Ar(iPr8)Co(η(6)-toluene)} with O2. Both 1 and 2 were characterized by X-ray crystallography, UV-vis spectroscopy, magnetic measurements, and, in the case of 1, Mössbauer spectroscopy. The solid-state structures of both compounds reveal unique M2(μ-O)2 (M = Fe (1), Co(2)) cores with formally three-coordinate metal ions. The Fe···Fe separation in 1 bears a resemblance to that in the Fe2(μ-O)2 diamond core proposed for the methane monooxygenase intermediate Q. The structural differences between 1 and 2 are reflected in rather differing magnetic behavior. Compound 2 is thermally unstable, and its decomposition at room temperature resulted in the oxidation of the Ar(iPr8) ligand via oxygen insertion and addition to the central aryl ring of the terphenyl ligand to produce the 5,5'-peroxy-bis[4,6-(i)Pr2-3,7-bis(2,4,6-(i)Pr3-phenyl)oxepin-2(5H)-one] (3). The structure of the oxidized terphenyl species is closely related to that of a key intermediate proposed for the oxidation of benzene. PMID:26331405

  5. Discovery of 8-Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)

    PubMed Central

    2015-01-01

    The success of imatinib, a BCR-ABL inhibitor for the treatment of chronic myelogenous leukemia, has created a great impetus for the development of additional kinase inhibitors as therapeutic agents. However, the complexity of cancer has led to recent interest in polypharmacological approaches for developing multikinase inhibitors with low toxicity profiles. With this goal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structure–activity relationship trends that can be exploited in the design of potent kinase inhibitors. One compound, 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x), was found to be the most active, inducing apoptosis of tumor cells at a concentration of approximately 30–100 nM. In vitro kinase profiling revealed that 7x is a multikinase inhibitor with potent inhibitory activity against the CDK4/CYCLIN D1 and ARK5 kinases. Here, we report the synthesis, structure–activity relationship, kinase inhibitory profile, in vitro cytotoxicity, and in vivo tumor regression studies by this lead compound. PMID:24417566

  6. Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).

    PubMed

    Reddy, M V Ramana; Akula, Balireddy; Cosenza, Stephen C; Athuluridivakar, Saikrishna; Mallireddigari, Muralidhar R; Pallela, Venkat R; Billa, Vinay K; Subbaiah, D R C Venkata; Bharathi, E Vijaya; Vasquez-Del Carpio, Rodrigo; Padgaonkar, Amol; Baker, Stacey J; Reddy, E Premkumar

    2014-02-13

    The success of imatinib, a BCR-ABL inhibitor for the treatment of chronic myelogenous leukemia, has created a great impetus for the development of additional kinase inhibitors as therapeutic agents. However, the complexity of cancer has led to recent interest in polypharmacological approaches for developing multikinase inhibitors with low toxicity profiles. With this goal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structure-activity relationship trends that can be exploited in the design of potent kinase inhibitors. One compound, 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x), was found to be the most active, inducing apoptosis of tumor cells at a concentration of approximately 30-100 nM. In vitro kinase profiling revealed that 7x is a multikinase inhibitor with potent inhibitory activity against the CDK4/CYCLIN D1 and ARK5 kinases. Here, we report the synthesis, structure-activity relationship, kinase inhibitory profile, in vitro cytotoxicity, and in vivo tumor regression studies by this lead compound.

  7. Umbra Ver. 4.8

    2010-02-24

    Umbra is a software package that has been in development at Sandia National Laboratories since 1995, under the name Umbra since 1997. Umbra is a software framework written in C++ and Tcl/Tk that has been applied to many operations, primarily dealing with robotics and simulation. Umbra executables are C++ libraries orchestrated with Tcl/Tk scripts. Two major feature upgrades occurred from 4.7 to 4.8 1. System Umbra Module with its own Update Graph within the C++more » framework. 2. New terrain graph for fast line-of-sight calculations All else were minor updates such as later versions of Visual Studio, OpenSceneGraph and Boost.« less

  8. 8 CFR 217.6 - Carrier agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Carrier agreements. 217.6 Section 217.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS VISA WAIVER PROGRAM § 217... may notify a carrier of the existence of a basis for termination of a carrier agreement under...

  9. 8 CFR 217.6 - Carrier agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Carrier agreements. 217.6 Section 217.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS VISA WAIVER PROGRAM § 217... may notify a carrier of the existence of a basis for termination of a carrier agreement under...

  10. 8 CFR 217.6 - Carrier agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Carrier agreements. 217.6 Section 217.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS VISA WAIVER PROGRAM § 217... may notify a carrier of the existence of a basis for termination of a carrier agreement under...

  11. 8 CFR 217.6 - Carrier agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Carrier agreements. 217.6 Section 217.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS VISA WAIVER PROGRAM § 217... may notify a carrier of the existence of a basis for termination of a carrier agreement under...

  12. 8 CFR 217.6 - Carrier agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Carrier agreements. 217.6 Section 217.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS VISA WAIVER PROGRAM § 217... may notify a carrier of the existence of a basis for termination of a carrier agreement under...

  13. Fourier-transform microwave spectroscopy of triplet carbon monoxides, C2O, C4O, C6O, and C8O

    NASA Astrophysics Data System (ADS)

    Ohshima, Yasuhiro; Endo, Yasuki; Ogata, Teruhiko

    1995-01-01

    Rotational spectra of CnO with n=2, 4, 6, and 8 have been observed by using a Fabry-Perot type Fourier-transform microwave spectrometer cooperated with a pulsed discharge nozzle. The molecules have been generated by an electric discharge of carbon suboxide diluted in Ar, and adiabatically cooled to ≊2 K in a subsequent supersonic expansion. All the observed spectra for these species are characterized as linear molecules in the 3Σ- electronic ground state. Since all the three spin sublevels have been detected even in the free-jet condition, the spin-spin coupling constants have been determined precisely as well as other spectroscopic constants. The coupling constants show rapid increase as n becomes larger, indicating smaller energy gaps between the excited 1Σ+ state and the 3Σ- ground state for the longer species. Along with the recent observation of singlet CnO (n=5, 7, and 9) [Ogata, Ohshima, and Endo, J. Am. Chem. Soc. (submitted)], the present study has established the existence of a complete set of the linear carbon-chain series CnO up to n=9 in the gas phase. The effective C=C bond lengths evaluated from the rotational constants decrease gradually to a converging value of ≊1.28 Å as n becomes larger. No apparent quasilinearity has been observed in the centrifugal-distortion constants of all the members, in contrast to the relevant series of the pure carbon clusters, Cn, some of which (n=3 and 7) have shown substantial nonrigidity for the bending vibration.

  14. Effect of chemical ordering on the crystallization behavior of Se90Te10-xSnx (x=2, 4, 6, and 8) chalcogenide glasses

    NASA Astrophysics Data System (ADS)

    Lafi, Omar A.; Imran, Mousa M. A.; Abu-Shaweesh, Nazem I.; Al-Kurdi, Fares M.; Khatatbeh, Ibtehaj K.

    2014-06-01

    Ternary Se90Te10-xSnx (x=2, 4, 6, and 8) chalcogenide glassy alloys have been prepared by melt quenching technique. Various crystallization parameters, such as onset (Tc) and peak (Tp) crystallization temperatures, activation energy of crystallization (Ec) and Avrami exponent (n) have been determined for these alloys. Tc and Tp have been determined directly from the non-isothermal differential scanning calorimeter (DSC) thermograms. The value of Ec has been calculated from the variation of both Tc and Tp with the heating rate (β) according to Kissinger, Takhor, Augis-Bennett and Ozawa models while Augis-Bennett method has been used to deduce the value of n for the studied samples. The obtained values of the crystallization parameters have been correlated with the character and the energy of the chemical bonds through the calculation of the heteronuclear bond energies of the constituent atoms using Pauling principle. In addition to that, Tichy-Ticha model was used to estimate the mean bond energy of the average cross-linking per atom , the average bond energy per atom of the remaining matrix , and the overall mean bond energy of the studied glasses. Results reveal that both of Tc and Tp decreases with increases Sn content. This is may be attributed to the decreasing in the overall mean bond energy . Besides, the plot of Ec (and also Tg) against was found to be non linear, which contradicts the well known linear correlation between Ec and Tg with as suggested by Tichy-Ticha model. This discrepancy may be due to the fact that the Tichy-Ticha linear correlation model was based on the assumption of covalent glassy network, while in the present glassy alloys, Se-Te binary doped with heavy elements such as Sn exhibit iono-covalent bonding. The calculated values of the ionicity are in support of this argument.

  15. Hydrothermal synthesis and characterization of a new organically templated three-dimensional open-framework gallium phosphate-phosphite (C 6N 2H 18) 2(C 6N 2H 17)Ga 15(OH) 8(PO 4) 2(HPO 4) 12(HPO 3) 6·2H 2O

    NASA Astrophysics Data System (ADS)

    Zhou, Guangpeng; Yang, Yulin; Fan, Ruiqing; Liu, Xinrong; Hong, Hengwu; Wang, Fuping

    2010-07-01

    Using H 3PO 3 as a phosphorus source and oxalic acid as a reducing agent, the first three-dimensional open-framework gallium phosphate-phosphite formula as (C 6N 2H 18) 2(C 6N 2H 17)Ga 15(OH) 8(PO 4) 2(HPO 4) 12(HPO 3) 6·2H 2O ( 1), has been hydrothermally synthesized in the presence of N,N,N',N'-tetramethylenediamine (TMEDA) as a structure-directing agent. Compound 1 crystallizes in trigonal system with space group P - 3, a = b = 19.046(3) Å, c = 8.3306(17) Å, γ = 120°, V = 2617.1(7) Å 3, and Z = 1. Its 3-D network is based on alternated Ga-centered (GaO 4 tetrahedra, GaO 5 trigonal bipyramids, and GaO 6 octahedra) and P-centered (PO 43-, HPO 42-, and HPO 32-) units. Protonated organic amines and water molecules are located in the 12-membered ring channels.

  16. RDamage 6, 7, 8 & 9 Cassettes

    SciTech Connect

    Griego, Jeffrey R; Kaul, Ann

    2012-06-08

    The RDamage series of ten experiments is part of a long-term collaboration with RFNC/VNIIEF in pulsed power technology. These experiments use a cylindrical configuration to study spallation damage, which allows for a natural recollection of the damaged material under proper driving conditions and post-shot collection of the damaged target material for subsequent metallographic analysis. Dynamic insitu experimental velocimetry diagnostics are also employed. LANL is responsible for the design of the experimental load and velocimetry system. VNIIEF is responsible for the design and construction of the driving explosive magnetic generator. In the RDamage-0, -1 and -2 experiments, data was collected about failure initiation of a well-characterized material (aluminum) in a cylindrical geometry. The RDamage-3, -4 and -5 experiments produced data on the behavior of material recollected after damage from pressures in the damage initiation regime. Data on the behavior of material recollected after complete failure was collected in the RDamage-6, -7, -8 and -9 experiments. This presentation shows the evolution of the load assembly through the experimental series.

  17. Synthesis and structural study of 4-(2-chlorophenyl)-2-ethoxy-5,6,7,8,9,10-hexahydrocycloocta[B]pyridine-3-carbonitrile

    NASA Astrophysics Data System (ADS)

    Fathima, K. Saiadali; Vasumathi, M.; Anitha, K.

    2016-05-01

    The novel organic material C20H21ClN2O was synthesized by One-Pot synthesis method and the single crystals were grown by slow evaporation solution growth technique. The crystal structure was elucidated by subjecting the grown crystals to the single crystal x-ray diffraction analysis and was refined by full matrix least-squares method to R=0.039 for 2746 reflections. Crystal system of the grown crystal was found to be monoclinic with the space group P21/a and a=9.196(4) Å, b=13.449(4) Å, c=14.818(4) Å, β= 101.542(3)°, V=1795.6(11) Å3 and Z=4. In this crystal structure, cyclooctanone prefers to reside in a chair-boat conformation. The structure is stabilized by attractive molecular force such as CH/π interaction called hydrophobic interaction.

  18. (4R,7S)-2-Amino-4-(3,4-dimeth­oxy­phen­yl)-5-oxo-7-phenyl-5,6,7,8-tetra­hydro-4H-chromene-3-carbonitrile monohydrate

    PubMed Central

    Sun, Rong; Wu, Dong-Dong; Wang, Ke; Huang, Wei; Ou, Yang-Bing

    2012-01-01

    The title compound, C24H22N2O4·H2O, was obtained by the reaction of 3,4-dimeth­oxy­benzaldehyde, malononitrile and 5-phenyl­cyclo­hexane-1,3-dione. The cyclo­hexyl and pyran rings show half-boat and V-shaped conformations, respectively. The dihedral angle between the phenyl and benzene ring planes is 30.67 (9)°. The organic mol­ecules are packed in a two-dimensional network parallel to the bc plane stabilized by inter­molecular N—H⋯N and N—H⋯O hydrogen bonds. PMID:22347026

  19. Mild hydrothermal synthesis, crystal structure, thermal behavior, spectroscopic and magnetic properties of the (NH 4)[Fe(AsO 4) 1-x(PO 4) xF] ( x=0.3, 0.6, 0.8) series. Thermal transformation of (NH 4)[Fe(AsO 4) 0.7(PO 4) 0.3F] into the textural porous orthorhombic Fe(AsO 4) 0.7(PO 4) 0.3

    NASA Astrophysics Data System (ADS)

    Berrocal, Teresa; Mesa, José L.; Pizarro, José L.; Bazán, Begoña; Lezama, Luis; Arriortua, María I.; Rojo, Teófilo

    2009-04-01

    The (NH 4)[Fe(AsO 4) 1-x(PO 4) xF] ( x=0.3, 0.6, 0.8) series of compounds has been synthesized under mild hydrothermal conditions. The compounds crystallize in the orthorhombic Pna2 1 space group, with the unit-cell parameters a=13.1718(1), b=6.5966(6), c=10.797(1) Å for x=0.3; a=13.081(1), b=6.5341(6), c=10.713(1) Å for x=0.6 and a=13.0329(9), b=6.4994(4), c=10.6702(6) Å for x=0.8, with the volumes 938.6(1), 915.7(1) and 903.8(1) Å 3, respectively, with Z=8. Single crystals of (NH 4)[Fe(AsO 4) 0.7(PO 4) 0.3F] heated under air atmosphere at 465 °C remain as single crystals, changing the composition to Fe(AsO 4) 0.7(PO 4) 0.3. This later phase belongs to the orthorhombic Imam space group, with the unit cell parameters a=13.328(2), b=6.5114(5), c=10.703(1) Å, V=928.9(2) Å 3 and Z=12. The crystal structure of the ammonium phases consists of a KTP three-dimensional framework constructed by chains formed by alternating Fe(2)O 4F 2 or Fe(1)O 4F 2 octahedra and As/P(2)O 4 or As/P(1)O 4 tetrahedra, respectively. These octahedra and tetrahedra are linked by a common oxygen vertex. The chains run along the " a" and " b" crystallographic axes. The crystal structure of Fe(AsO 4) 0.7(PO 4) 0.3 is a three-dimensional skeleton derived from that of the precursor, formed from (100) sheets stacked along the [001] direction, and interconnected by chains of alternating Fe(2)O 6 octahedra and As/P(2)O 4 tetrahedra sharing a vertex in the " a" direction. Transmission electronic microscopy of this compound indicates the existence of unconnected external cavities with a BET surface area of 3.91(3) m 2 g -1. The diffuse reflectance spectra in the visible region show the forbidden electronic transitions characteristic of the Fe(III) d5-high spin cation in slightly distorted octahedral geometry, for all the compounds. The ESR spectra for all the compounds, carried out from room temperature to 4.2 K, remain isotropic with variation in temperature; the g-value is 1.99(1). Magnetic

  20. 22 CFR 8.6 - Membership.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.6 Membership. (a) The act requires a balanced... committee's functions and should be chosen from different vocations having knowledge in the subject. (b) It..., sex, or color. (c) The committee office will keep the Advisory Committee Management Officer...

  1. 22 CFR 8.6 - Membership.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.6 Membership. (a) The act requires a balanced... committee's functions and should be chosen from different vocations having knowledge in the subject. (b) It..., sex, or color. (c) The committee office will keep the Advisory Committee Management Officer...

  2. 48 CFR 8.406-6 - Disputes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... issued the final decision or the U.S. Court of Federal Claims. (d) Alternative dispute resolution. The contracting officer should use the alternative dispute resolution (ADR) procedures, to the maximum extent... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Disputes. 8.406-6...

  3. Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime.

    PubMed

    Amici, Raffaella; Bigogno, Chiara; Boggio, Roberto; Colombo, Andrea; Courtney, Stephen M; Dal Zuffo, Roberto; Dondio, Giulio; Fusar, Fulvia; Gagliardi, Stefania; Minucci, Saverio; Molteni, Marco; Montalbetti, Christian A G N; Mortoni, Annalisa; Varasi, Mario; Vultaggio, Stefania; Mercurio, Ciro

    2014-07-01

    Heat-shock protein 90 (Hsp90) is a molecular chaperone involved in the stabilization of key oncogenic signaling proteins, and therefore, inhibition of Hsp90 represents a new strategy in cancer therapy. 2-Amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime is a racemic Hsp90 inhibitor that targets the N-terminal adenosine triphosphatase site. We developed a method to resolve the enantiomers and evaluated their inhibitory activity on Hsp90 and the consequent antitumor effects. The (S) stereoisomer emerged as a potent Hsp90 inhibitor in biochemical and cellular assays. In addition, this enantiomer exhibited high oral bioavailability in mice and excellent antitumor activity in two different human cancer xenograft models.

  4. X-ray studies of 2-amino-4-(3-nitrophenyl)-5-oxo-4,5-dihydropyrano[3,2- c] chromene-3-carbonitrile and 2-amino-7,7-dimethyl-4-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4 H-chromene-3-carbonitrile

    NASA Astrophysics Data System (ADS)

    Sharma, S.; Banerjee, B.; Brahmachari, G.; Kant, R.; Gupta, V. K.

    2015-12-01

    Two carbonitrile compounds, 2-amino-4-(3-nitrophenyl)-5-oxo-4,5-dihydropyrano[3,2- c] chromene-3-carbonitrile ( I) and 2-amino-7,7-dimethyl-4-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4 H-chromene-3-carbonitrile ( II), were synthesized, and their crystal structures were determined by X-ray diffraction technique. The crystals are triclinic, a = 7.7970(12), 8.2171(7), b = 9.0390(10), 9.2238(7), c = 15.148(2), 14.5585(11) Å, α = 81.439(10)°, 74.895(6)°, β = 75.194(12)°, 87.392(6)°, γ = 76.151(11)°, 78.552(7)°, for I and II, respectively, Z = 2, sp. gr. P overline 1. The pyran ring in both the compounds deviates significantly from planarity and adopts boat conformation. The crystal structure is stabilized by N-H···O and N-H···N hydrogen bonds.

  5. 5-Demethylnobiletin and 5-Acetoxy-6,7,8,3',4'-pentamethoxyflavone Suppress Lipid Accumulation by Activating the LKB1-AMPK Pathway in 3T3-L1 Preadipocytes and High Fat Diet-Fed C57BL/6 Mice.

    PubMed

    Tung, Yen-Chen; Li, Shiming; Huang, Qingrong; Hung, Wei-Lun; Ho, Chi-Tang; Wei, Guor-Jien; Pan, Min-Hsiung

    2016-04-27

    Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones (HPMFs), such as nobiletin (Nob) and 5-demethylnobiletin (5-OH-Nob), are unique flavonoids that are found exclusively in citrus peels. Nobiletin has been shown to suppress adipogenesis in vitro, but the antiadipogenic activity of 5-OH-Nob has not been investigated. Both nobiletin and 5-OH-Nob have poor aqueous solubility and low oral bioavailability. We employed chemical modification to produce the acetyl derivative of 5-OH-Nob, that is, 5-acetyloxy-6,7,8,3',4'-pentamethoxyflavone (5-Ac-Nob), to improve its bioavailability and bioactive efficiency. We found that 5-Ac-Nob reduced triacylglycerol (TG) content to a greater extent than 5-OH-Nob in 3T3-L1 preadipocytes. Orally administered 5-Ac-Nob resulted in a significant reduction in body weight, intra-abdominal fat, plasma and liver TG levels, and plasma cholesterol level in high fat diet-induced obese male C57BL/6J mice. The 5-Ac-Nob treatment decreased lipid accumulation by triggering the adenosine 5'-monophosphate-activated protein kinase (AMPK) pathway to alter transcriptional factors or lipogenesis-related enzymes in vivo and in vitro. PMID:27041493

  6. Solid-phase synthesis of 2-substituted 4-amino-7-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidines.

    PubMed

    Falcó, José L; Borrell, José I; Teixidó, Jordi

    2003-01-01

    An efficient solid-phase synthesis of 2-substituted 4-aminopyrido[2,3-d]pyrimidines 15 is reported. The procedure started by solid supporting a p-hydroxybenzaldehyde 8 to the Wang resin by using the Mitsunobu protocol. The resulting aldehyde 17 was treated with a substituted acid methyl malonate 10 to afford the corresponding alpha, beta-unsaturated ester 18, which was converted to the Michael adduct 21 by reaction with malononitrile. Cyclization of 21 with an amidine system 13 yielded the solid supported pyridopyrimidine 22, which afforded the corresponding 2-substituted 4-aminopyrido[2,3-d]pyrimidine 15 upon treatment with TFA:DCM. Compounds 15 present three diversity centers R1, R2 and R3. Having validated the chemistry on solid support, a 32-membered combinatorial library was obtained using this protocol.

  7. Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrative nucleoside transporter probe.

    PubMed

    Lin, Wenwei; Buolamwini, John K

    2011-06-15

    Nucleoside transporters are integral membrane glycoproteins that play critical roles in physiological nucleoside and nucleobase fluxes, and influence the efficacy of many nucleoside chemotherapy drugs. Fluorescent reporter ligands/substrates have been shown to be useful in the analysis of nucleoside transporter (NT) protein expression and discovery of new NT inhibitors. In this study, we have developed a novel dipyridamole (DP)-based equilibrative nucleoside transporter 1 (ENT1) fluorescent probe. The potent ENT1 and ENT2 inhibitor analogue of dipyridamole, 2,6-bis(diethanolamino)-4,8-diheptamethyleneiminopyrimido[5,4-d]pyrimidine (4, 8MDP), was modified to replace one β-hydroxyethyl group of the amino substituent at the 2-position with a β-aminoethyl group and then conjugated through the amino group to 6-(fluorescein-5-carboxamido)hexanoyl moiety to obtain a new fluorescent molecule, 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate, designated 8MDP-fluorescein (8MDP-fluor, 6). The binding affinities of 8MDP-fluor at ENT1 and ENT2 are reflected by the uridine uptake inhibitory K(i) values of 52.1 nM and 285 nM, respectively. 8MDP-fluor was successfully demonstrated to be a flow cytometric probe for ENT1 comparable to the nitrobenzylmercaptopurine riboside (NBMPR) analogue ENT1 fluorescent probe SAENTA-X8-fluorescein (SAENTA-fluor, 1). This is the first reported dipyridamole-based ENT1 fluorescent probe, which adds a novel tool for probing ENT1, and possibly ENT2.

  8. Synthesis and antiviral evalution of some novel pyrazoles and pyrazolo[3,4-d]pyridazines bearing 5,6,7,8-tetrahydronaphthalene.

    PubMed

    Hamdy, Nehal A; El-Senousy, Waled M

    2013-01-01

    The enaminone 2 was reacted with hydrazonyl halides 3a-d to afford the corresponding pyrazole derivatives (6a-d) which reacted with hydrazine hydrate to afford the new pyrazolo[3,4-d]pyridazine derivatives 7a-d, respectively. In addition, compound 2 was reacted with some primary aromatic amines to afford the corresponding secondary enaminones 10a-c and reacted with sulfapyridine or sulfapyrimidine to afford the corresponding sulfonamide derivatives 12a and 12b. Evaluation of these new compounds against rotavirus Wa strain and adenovirus type 7 showed promising antiviral activity.

  9. Synthesis, magnetism, and electrochemistry of the Ni14- and Ni5-containing heteropolytungstates [Ni14(OH)6(H2O)10(HPO4)4(P2W15O56)4]34- and [Ni5(OH)4(H2O)4(β-GeW9O34)(β-GeW8O30(OH))]13-.

    PubMed

    Ibrahim, Masooma; Xiang, Yixian; Bassil, Bassem S; Lan, Yanhua; Powell, Annie K; de Oliveira, Pedro; Keita, Bineta; Kortz, Ulrich

    2013-08-01

    The two Ni(2+)-containing heteropolytungstates [Ni14(OH)6(H2O)10(HPO4)4(P2W15O56)4](34-) (Ni14) and [Ni5(OH)4(H2O)4(β-GeW9O34)(β-GeW8O30(OH))](13-) (Ni5) have been successfully synthesized in aqueous, basic media under conventional reaction conditions, and they were characterized by single-crystal X-ray diffraction, IR spectroscopy, thermogravimetric and elemental analyses, electrochemistry, and magnetic studies. The cyclic voltammetry (CV) patterns of Ni14 and Ni5 showed chemically reversible multielectronic waves for slow scan time scales. For Ni14, an important acidity inversion effect between its reduced forms was observed. Magnetic studies revealed dominant ferromagnetic interactions among the nickel(II) ions in both polyanions.

  10. (2R)-4-Oxo-4[3-(Trifluoromethyl)-5,6-diihydro:1,2,4}triazolo[4,3-a}pyrazin-7(8H)-y1]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

    SciTech Connect

    Kim, D.; Wang, L.; Beconi, M.; Eiermann, G.; Fisher, M.; He, H.; Hickey, G.; Kowalchick, Jennifer; Leiting, Barbara; Lyons, K.; Marsilio, F.; McCann, F.; Patel, R.; Petrov, A.; Scapin, G.; Patel, S.; Roy, R.; Wu, J.; Wyvratt, M.; Zhang, B.; Zhu, L.; Thornberry, N.; Weber, A.

    2010-11-10

    A novel series of {beta}-amino amides incorporating fused heterocycles, i.e., triazolopiperazines, were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV) for the treatment of type 2 diabetes. (2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine (1) is a potent, orally active DPP-IV inhibitor (IC{sub 50} = 18 nM) with excellent selectivity over other proline-selective peptidases, oral bioavailability in preclinical species, and in vivo efficacy in animal models. MK-0431, the phosphate salt of compound 1, was selected for development as a potential new treatment for type 2 diabetes.

  11. Expression profiles of the immune genes CD4, CD8β, IFNγ, IL-4, IL-6 and IL-10 in mitogen-stimulated koala lymphocytes (Phascolarctos cinereus) by qRT-PCR.

    PubMed

    Maher, Iona E; Griffith, Joanna E; Lau, Quintin; Reeves, Thomas; Higgins, Damien P

    2014-01-01

    Investigation of the immune response of the koala (Phascolarctos cinereus) is needed urgently, but has been limited by scarcity of species-specific reagents and methods for this unique and divergent marsupial. Infectious disease is an important threat to wild populations of koalas; the most widespread and important of these is Chlamydial disease, caused by Chlamydia pecorum and Chlamydia pneumoniae. In addition, koala retrovirus (KoRV), which is of 100% prevalence in northern Australia, has been proposed as an important agent of immune suppression that could explain the koala's susceptibility to disease. The correct balance of T regulatory, T helper 1 (Th1) and Th2 lymphocyte responses are important to an individual's susceptibility or resistance to chlamydial infection. The ability to study chlamydial or KoRV pathogenesis, effects of environmental stressors on immunity, and the response of koalas to vaccines under development, by examining the koala's adaptive response to natural infection or in-vitro stimulation, has been limited to date by a paucity of species- specific reagents. In this study we have used cytokine sequences from four marsupial genomes to identify mRNA sequences for key T regulatory, Th1 and Th2 cytokines interleukin 4 (IL-4), interleukin 6 (IL-6), interleukin 10 (IL-10) and interferon gamma (IFNγ) along with CD4 and CD8β. The koala sequences used for primer design showed >58% homology with grey short-tailed opossum, >71% with tammar wallaby and 78% with Tasmanian devil amino acid sequences. We report the development of real-time RT-PCR assays to measure the expression of these genes in unstimulated cells and after three common mitogen stimulation protocols (phorbol myristate acetate/ionomycin, phorbol myristate acetate/phytohemagglutinin and concanavalin A). Phorbol myristate acetate/ionomycin was found to be the most effective mitogen to up-regulate the production of IL-4, IL-10 and IFNγ. IL-6 production was not consistently up-regulated by

  12. 2-[6,8-Dibromo-3-(4-hydroxy­cyclo­hexyl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]-6-methoxy­phenol

    PubMed Central

    Wang, Zhi-Gang; Wang, Rong; Zhang, Yi; Zhi, Feng; Yang, Yi-Lin

    2009-01-01

    The title compound, C21H24Br2N2O3, was synthesized by the condensation reaction of 3-methoxy­salicylaldehyde with 4-(2-amino-3,5-dibromo­benzyl­amino)cyclo­hexa­nol in a methanol solution. The dihedral angle between the two benzene rings is 76.4 (3)°. The cyclo­hexyl ring adopts a chair configuration. There is an intra­molecular O—H⋯N hydrogen bond which affects the solid state conformation of the mol­ecule. The crystal structure is stabilized by inter­molecular O—H⋯O hydrogen bonds, forming chains running along the b axis. PMID:21582209

  13. 4-(4-Bromo-phen-yl)-7,7-dimethyl-2-methyl-amino-3-nitro-7,8-di-hydro-4H-chromen-5(6H)-one including an unknown solvate.

    PubMed

    Inglebert, S Antony; Kamalraja, Jayabal; Sethusankar, K; Vasuki, Gnanasambandam

    2014-05-01

    In the title compound, C18H19BrN2O4, the chromene unit is not quite planar (r.m.s. deviation = 0.199 Å), with the methyl C atoms lying 0.027 (4) and 1.929 (4) Å from the mean plane of the chromene unit. The six-membered carbocyclic ring of the chromene moiety adopts an envelope conformation, with the dimethyl-substituted C atom as the flap. The methyl-amine and nitro groups are slightly twisted from the chromene moiety, with C-N-C-O and O-N-C-C torsion angles of 2.7 (4) and -0.4 (4)°, respectively. The dihedral angle between the mean plane of the chromene unit and the benzene ring is 85.61 (13)°. An intra-molecular N-H⋯O hydrogen bond generates an S(6) ring motif, which stabilizes the mol-ecular conformation. In the crystal, mol-ecules are linked via N-H⋯O hydrogen bonds, forming hexa-gonal rings lying parallel to the ab plane. A region of disordered electron density, most probably disordered ethanol solvent mol-ecules, occupying voids of ca 432 Å(3) for an electron count of 158, was treated using the SQUEEZE routine in PLATON [Spek (2009 ▶). Acta Cryst. D65, 148-155]. Their formula mass and unit-cell characteristics were not taken into account during refinement. PMID:24860381

  14. Synthesis, structure activity relationship and mode of action of 3-substitutedphenyl-1-(2,2,8,8-tetramethyl-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenones as novel anticancer agents in human leukaemia HL-60 cells.

    PubMed

    Murthy, Y L N; Suhasini, K P; Pathania, A S; Bhushan, S; Nagendra Sastry, Y

    2013-04-01

    A novel class of 3-substitutedphenyl-1-(2,2,8,8-tetramethyl-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromen-6-yl)-propenones were designed, synthesized and evaluated for their antiproliferative activity against the human cancer cell lines of diverse origin. Structure activity relationship was elucidated with various substitutions on the benzene ring and these variations significantly affected the potency. Most of the twelve tested compounds inhibited the growth of aggressive cancer cell lines. Moreover, three compounds 4j, 4k and 4l displayed excellent cytotoxic profile by inhibiting >90% cell proliferation in HL-60 and Caco-2 cells at 50 μM concentration. Further studies to elucidate the mode of action revealed that these three compounds induced G0/G1 cell cycle arrest and apoptosis, which was accompanied by loss of mitochondrial membrane potential, DNA fragmentation and nuclear morphology in HL-60 cells.

  15. 7 CFR 8.4 - Basic premises.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Basic premises. 8.4 Section 8.4 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.4 Basic premises. (a) The 4-H Club Name and Emblem are held in trust by the Secretary of Agriculture of the United States Department of...

  16. 7 CFR 8.4 - Basic premises.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Basic premises. 8.4 Section 8.4 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.4 Basic premises. (a) The 4-H Club Name and Emblem are held in trust by the Secretary of Agriculture of the United States Department of...

  17. 7 CFR 8.4 - Basic premises.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Basic premises. 8.4 Section 8.4 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.4 Basic premises. (a) The 4-H Club Name and Emblem are held in trust by the Secretary of Agriculture of the United States Department of...

  18. 7 CFR 8.4 - Basic premises.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Basic premises. 8.4 Section 8.4 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.4 Basic premises. (a) The 4-H Club Name and Emblem are held in trust by the Secretary of Agriculture of the United States Department of...

  19. 7 CFR 8.4 - Basic premises.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Basic premises. 8.4 Section 8.4 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.4 Basic premises. (a) The 4-H Club Name and Emblem are held in trust by the Secretary of Agriculture of the United States Department of...

  20. Spectroscopic and structural characterization of the charge-transfer interaction of N,N'-bis-alkyl derivatives of 1,4,6,8-naphthalenediimide with chloranilic and picric acids

    NASA Astrophysics Data System (ADS)

    Refat, Moamen S.; Ahmed, Hamdy A.; Grabchev, Ivo; El-Zayat, Lamia A.

    2008-09-01

    Charge-transfer (CT) complexes formed from the reactions of two N,N'-bis-alkyl derivatives of 1,4,6,8-naphthalenediimide such as N, N'-bis[2-hydroxyethyl)]-1,4,6,8-naphthalenediimide (BHENDI) and N, N'-bis-[2- N, N-dimethylaminoethyl)]-1,4,6,8-naphthalenediimide (BDMAENDI) with chloranilic acid (CLA) and piciric acid (PA) as π-acceptors, have been studied spectrophotometrically in methanol and chloroform, respectively at 25 °C. The photometric titration curves for the reactions indicated that the data obtained refer to 1:1 charge-transfer complexes of [(BHENDI)(CLA)], [(BDMAENDI)(CLA)], [(BHENDI)(PA)] and [(BDMAENDI)(PA)] were formed. Benesi-Hildebrand and its modification methods were applied to the determination of association constant ( K), molar extinction coefficient ( ɛ). The solid CT complexes have been synthesized and characterization by different spectral methods.

  1. Pump-probe photoelectron velocity-map imaging of autoionizing singly excited 4s14p6np1(n=7,8) and doubly excited 4s24p45s16p1 resonances in atomic krypton

    NASA Astrophysics Data System (ADS)

    Doughty, Benjamin; Haber, Louis H.; Leone, Stephen R.

    2011-10-01

    Pump-probe photoelectron velocity-map imaging, using 27-eV high-harmonic excitation and 786-nm ionization, is used to resolve overlapping autoionizing resonances in atomic krypton, obtaining two-photon photoelectron angular distributions (PADs) for singly and doubly excited states. Two features in the photoelectron spectrum are assigned to singly excited 4s14p6np1 (n = 7,8) configurations and four features provide information about double excitation configurations. The anisotropy parameters for the singly excited 7p configuration are measured to be β2 = 1.61 ± 0.06 and β4 = 1.54 ± 0.16 while the 8p configuration gives β2 = 1.23 ± 0.19 and β4 = 0.60 ± 0.15. These anisotropies most likely represent the sum of overlapping PADs from states of singlet and triplet spin multiplicities. Of the four bands corresponding to ionization of doubly excited states, two are assigned to 4s24p45s16p1 configurations that are probed to different J-split ion states. The two remaining doubly excited states are attributed to a previously observed, but unassigned, resonance in the vacuum-ultraviolet photoabsorption spectrum. The PADs from each of the double excitation states are also influenced by overlap from neighboring states that are not completely spectrally resolved. The anisotropies of the observed double excitation states are reported, anticipating future theoretical and experimental work to separate the overlapping PADs into the state resolved PADs. The results can be used to test theories of excited state ionization.

  2. Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice

    SciTech Connect

    Kopec, Anna K.; D'Souza, Michelle L.; Mets, Bryan D.; Burgoon, Lyle D.; Reese, Sarah E.; Archer, Kellie J.; Potter, Dave; Tashiro, Colleen; Sharratt, Bonnie; Harkema, Jack R.; Zacharewski, Timothy R.

    2011-10-15

    Interactions between environmental contaminants can lead to non-additive effects that may affect the toxicity and risk assessment of a mixture. Comprehensive time course and dose-response studies with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), non-dioxin-like 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) and their mixture were performed in immature, ovariectomized C57BL/6 mice. Mice were gavaged once with 30 {mu}g/kg TCDD, 300 mg/kg PCB153, a mixture of 30 {mu}g/kg TCDD with 300 mg/kg PCB153 (MIX) or sesame oil vehicle for 4,12, 24,72 or 168 h. In the 24 h dose-response study, animals were gavaged with TCDD (0.3,1, 3, 6, 10, 15, 30, 45 {mu}g/kg), PCB153 (3,10, 30, 60, 100, 150, 300, 450 mg/kg), MIX (0.3 + 3, 1 + 10, 3 + 30, 6 + 60, 10 + 100, 15 + 150, 30 + 300, 45 {mu}g/kg TCDD + 450 mg/kg PCB153, respectively) or vehicle. All three treatments significantly increased relative liver weights (RLW), with MIX eliciting significantly greater increases compared to TCDD and PCB153 alone. Histologically, MIX induced hepatocellular hypertrophy, vacuolization, inflammation, hyperplasia and necrosis, a combination of TCDD and PCB153 responses. Complementary lipid analyses identified significant increases in hepatic triglycerides in MIX and TCDD samples, while PCB153 had no effect on lipids. Hepatic PCB153 levels were also significantly increased with TCDD co-treatment. Microarray analysis identified 167 TCDD, 185 PCB153 and 388 MIX unique differentially expressed genes. Statistical modeling of quantitative real-time PCR analysis of Pla2g12a, Serpinb6a, Nqo1, Srxn1, and Dysf verified non-additive expression following MIX treatment compared to TCDD and PCB153 alone. In summary, TCDD and PCB153 co-treatment elicited specific non-additive gene expression effects that are consistent with RLW increases, histopathology, and hepatic lipid accumulation. - Graphical abstract: Display Omitted Highlights: > MIX (TCDD:PCB153 at 1:10,000 ratio) exposure leads to non-additive gene expression

  3. Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.

    PubMed

    Green, Neal; Hu, Yonghan; Janz, Kristin; Li, Huan-Qiu; Kaila, Neelu; Guler, Satenig; Thomason, Jennifer; Joseph-McCarthy, Diane; Tam, Steve Y; Hotchandani, Rajeev; Wu, Junjun; Huang, Adrian; Wang, Qin; Leung, Louis; Pelker, Jefferey; Marusic, Suzana; Hsu, Sang; Telliez, Jean-Baptiste; Hall, J Perry; Cuozzo, John W; Lin, Lih-Ling

    2007-09-20

    Tumor progression loci-2 (Tpl2) (Cot/MAP3K8) is a serine/threonine kinase in the MAP3K family directly upstream of MEK. Recent studies using Tpl2 knockout mice have indicated an important role for Tpl2 in the lipopolysaccharide (LPS) induced production of tumor necrosis factor alpha (TNF-alpha) and other proinflammatory cytokines involved in diseases such as rheumatoid arthritis. Initial 4-anilino-6-aminoquinoline-3-carbonitrile leads showed poor selectivity for Tpl2 over epidermal growth factor receptor (EGFR) kinase. Using molecular modeling and crystallographic data of the EGFR kinase domain with and without an EGFR kinase-specific 4-anilinoquinazoline inhibitor (erlotinib, Tarceva), we hypothesized that we could diminish the inhibition of EGFR kinase by substitution at the C-8 position of our 4-anilino-6-aminoquinoline-3-carbonitrile leads. The 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles were prepared from the appropriate 2-substituted 4-nitroanilines. Modifications to the C-6 and C-8 positions led to the identification of compounds with increased inhibition of TNF-alpha release from LPS-stimulated rat and human blood, and these analogues were also highly selective for Tpl2 kinase over EGFR kinase. Further structure-activity based modifications led to the identification of 8-bromo-4-(3-chloro-4-fluorophenylamino)-6-[(1-methyl-1H-imidazol-4-yl)methylamino]quinoline-3-carbonitrile, which demonstrated in vitro as well as in vivo efficacy in inhibition of LPS-induced TNF-alpha production. PMID:17715908

  4. Investigation of the metallurgical factors affecting hydrogen embrittlement of solution heat treated and aged Ti-3Al-8V-6Cr-4Mo-4Zr (wt.%) employing fracture, microscopy and desorption methods

    NASA Astrophysics Data System (ADS)

    Gaudett, Michelle Anne

    The effects of pre-dissolved hydrogen (H) on room temperature fracture initiation in Ti-3Al-8V-6Cr-4Mo-4Zr (wt%) have been investigated. The peak aged condition (STA) shows enhanced H embrittlement susceptibility compared to the solutionized condition (ST) as measured by reductions in the fracture initiation stress with H content and the introduction of intergranular (IG) fracture. Fracture initiation testing of cold worked, ST condition suggests that yield strength alone does not control H-assisted IG fracture initiation of the STA condition. Stroke rate studies, thermal desorption, transmission electron microscopy and x-ray diffraction investigations of H partitioning suggests that equilibrium hydriding and/or irreversible trapping do not singularly control IG fracture. Examination of additional metallurgical conditions show that grain boundary alpha colonies or films are not responsible for IG fracture. Deformation studies suggest that plastic deformation is concentrated at or near the grain boundaries in the STA condition. An increase in IG cracking with aging time is consistent with the segregation of a critical species to the grain boundaries. Therefore, a H-induced IG initiation mechanism that includes the deleterious effects of grain boundary segregation and deformation on the grain boundary fracture stress is proposed. Thermal desorption spectroscopy was employed to compare the hydrogen detrapping and desorption characteristics of the ST and STA conditions. Due to the oxide barrier that prevents H egress until high temperatures (˜350-400sp°C) and a dominant H desorption peak due to lattice H, resolution of possible trapping states was difficult. Modeling of H desorption showed that the ST and STA conditions do not have any trapping states of a binding energy greater than 65 kJ/mol. The limitations of the thermal desorption spectroscopy technique led us to examine and model the mechanism by which H desorbs from Ti-3Al-8V-6Cr-4Mo-4Zr. In the temperature

  5. Synthesis and Reactivity of (Pentafluorophenyl)platinate(II) Complexes with Bridging 1,8-Naphthyridine (napy) and X Ligands (X = C(6)F(5), OH, Cl, Br, I, SPh). Crystal Structure of [NBu(4)][Pt(2)(&mgr;-napy)(&mgr;-OH)(C(6)F(5))(4)].CHCl(3).

    PubMed

    Ara, Irene; Casas, José M.; Forniés, Juan; Rueda, Angel J.

    1996-12-01

    By reaction of [NBu(4)](2)[Pt(2)(&mgr;-C(6)F(5))(2)(C(6)F(5))(4)] with 1,8-naphthyridine (napy), [NBu(4)][Pt(C(6)F(5))(3)(napy)] (1) is obtained. This compound reacts with cis-[Pt(C(6)F(5))(2)(THF)(2)] to give the dinuclear derivative [NBu(4)][Pt(2)(&mgr;-napy)(&mgr;-C(6)F(5))(C(6)F(5))(4)] (2). The reaction of several HX species with 2 results in the substitution of the bridging C(6)F(5) by other ligands (X) such as OH (3), Cl (4), Br (5), I (6), and SPh (7), maintaining in all cases the naphthyridine bridging ligand. The structure of 3 was determined by single-crystal X-ray diffraction. The compound crystallizes in the monoclinic system, space group P2(1)/n, with a = 12.022(2) Å, b = 16.677(3) Å, c = 27.154(5) Å, beta = 98.58(3) degrees, V = 5383.2(16) Å(3), and Z = 4. The structure was refined to residuals of R = 0.0488 and R(w) = 0.0547. The complex consists of two square-planar platinum(II) fragments sharing a naphthyridine and OH bridging ligands, which are in cis positions. The short Pt-Pt distance [3.008(1) Å] seems to be a consequence of the bridging ligands.

  6. 8 CFR 1287.6 - Proof of official records.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Proof of official records. 1287.6 Section 1287.6 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE... existence on a certain date, and official and notarial authentication of signatures. (4) In accordance...

  7. 8 CFR 1287.6 - Proof of official records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Proof of official records. 1287.6 Section 1287.6 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE... existence on a certain date, and official and notarial authentication of signatures. (4) In accordance...

  8. 8 CFR 1287.6 - Proof of official records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Proof of official records. 1287.6 Section 1287.6 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE... existence on a certain date, and official and notarial authentication of signatures. (4) In accordance...

  9. 8 CFR 1287.6 - Proof of official records.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Proof of official records. 1287.6 Section 1287.6 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE... existence on a certain date, and official and notarial authentication of signatures. (4) In accordance...

  10. 8 CFR 1287.6 - Proof of official records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Proof of official records. 1287.6 Section 1287.6 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE... existence on a certain date, and official and notarial authentication of signatures. (4) In accordance...

  11. 8 CFR 274a.6 - State employment agencies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false State employment agencies. 274a.6 Section 274a.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROL OF...; (4) Contain the employer's name and address; (5) State the name and date of birth of the...

  12. Pseudo Jahn-Teller distortion for a tricyclic carbon sulfide (C6S8) and its suppression in S-oxygenated dithiine (C4H4(SO2)2)

    NASA Astrophysics Data System (ADS)

    Pratik, Saied Md.; Chowdhury, Chandra; Bhattacharjee, Rameswar; Jahiruddin, Sk.; Datta, Ayan

    2015-10-01

    The tricyclic carbon-sulfide, C6S8 molecule containing two S-atoms in the 1,4-position of the central six-membered ring and one disulfide (Ssbnd S) and one thione (Cdbnd S) bond on the five membered rings on its either side (1) possesses a "butterfly flapping" type distorted ground state in the gas-phase and also in β-phase of the crystal. For the isolated molecule, better consideration of the S…S non-bonding interactions in the dithiine ring in the bent form at the M06-2X/6-31+G(d,p) level leads to a significant barrier for inversion of 2.4 kcal/mol which is 2-3 times more than that previously obtained by Weber and Dolg at the B3LYP/cc-pVTZ level due to underestimation of dispersion interactions at the B3LYP level. The origin of the distortion leading to lowering of symmetry for 1 (C2h → C2) is traced to vibronic mixing between the ground state (Ag) and the low lying excited states of Au symmetry through the au normal mode, a (1Ag + 1Au + 2Au + 3Au) × au pseudo Jahn-Teller effect (PJTE) problem. Based on fitting of the ground state APES to the lowest root of the 4 × 4 secular determinant, we calculate the linear vibronic coupling constants (F0i) between the relevant states. Similar in class to 1, the S-oxygenated derivative of dithiine, C4H4(SO2)2 (2) unlike most other dithiines, remains planar. The absence of the butterfly-type puckered structure in 2 is traced to the enhanced gap (Δ0) and very small vibronic coupling (F01) between the ground and PJT active state along the au distortion which suppress the PJT instability. Considering the separation of the occupied molecular orbital (OMO) and unoccupied molecular orbitals (UMO) energy levels provide a qualitative understanding for the contrasting behavior of 1 and 2. In effect, the PJT effect is shown to be a fruitful and general tool to describe the presence or lack of molecular distortion.

  13. Pore-forming activity of Coxiella burnetii outer membrane protein oligomer comprised of 29.5- and 31-kDa polypeptides. Inhibition of porin activity by monoclonal antibodies 4E8 and 4D6.

    PubMed

    Banerjee-Bhatnagar, N; Bolt, C R; Williams, J C

    1996-07-23

    Envelopes of large-cell variant Coxiella burnetii, the agent of Q fever, were the starting material for purification of an outer membrane protein (OMP) oligomer with aggregate molecular mass of approximately 2 x 10(4) kDa. The oligomer was resistant to trypsin and dissociation by SDS at 100 degrees C. Reducing agents dissociated the oligomer into monomers of 29.5 and 31 kDa, which migrated as a doublet during SDS-polyacrylamide gel electrophoresis. Both monomers were reactive in an immunoblot assay with monoclonal antibodies (mAbs) 4E8 and 4D6, which were previously selected for their reactivity with purified and SDS-denatured 29.5 kDa protein. Proteoliposomes were functional in an equilibrium assay at pH 7 and a swelling assay at pH 7 and 4.5. The pores in proteoliposomes allowed the passage of arabinose, glucose, and sucrose, but restricted stachyose. Polyclonal antibodies to C. burnetii cells and the mAbs were able to bind C. burnetii at pH 7 and 4.5. The uptake of 14C-glucose at pH 4.5 was inhibited by polyclonal antibodies and mAbs after binding to cells at pH 7. The mAbs did not inhibit 14C-glucose uptake at pH 4.5 after binding to cells at pH 4.5. Although the mAbs bind C. burnetii porin epitopes before and after acid activation, the mAbs bound under acidic conditions were unable to inhibit porin function. The inhibition of porin channel function by mAbs confirms the role of porin as a permeability barrier for the subsequent active transport of glucose by C. burnetii. In another study, we showed that the 29.5 kDa OMP antigen induced active immunity against virulent challenge. This information, combined with the recent confirmation that porins are important antigens in the induction of specific protective immune responses against infection by gram-negative bacteria, suggests that humoral immunity directed against C. burnetii porins might play an important role in immunity against Q fever (human infection) and coxiellosis (animal infection), global enzootic

  14. 38 CFR 8a.4 - Coverage.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Coverage. 8a.4 Section 8a.4 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VETERANS MORTGAGE LIFE INSURANCE § 8a.4 Coverage. (a) The amount of VMLI in force on his or her life at any one time shall...

  15. 38 CFR 8a.4 - Coverage.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Coverage. 8a.4 Section 8a.4 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VETERANS MORTGAGE LIFE INSURANCE § 8a.4 Coverage. (a) The amount of VMLI in force on his or her life at any one time shall...

  16. 38 CFR 8a.4 - Coverage.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Coverage. 8a.4 Section 8a.4 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VETERANS MORTGAGE LIFE INSURANCE § 8a.4 Coverage. (a) The amount of VMLI in force on his or her life at any one time shall...

  17. 38 CFR 8a.4 - Coverage.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Coverage. 8a.4 Section 8a.4 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VETERANS MORTGAGE LIFE INSURANCE § 8a.4 Coverage. (a) The amount of VMLI in force on his or her life at any one time shall...

  18. 38 CFR 8a.4 - Coverage.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Coverage. 8a.4 Section 8a.4 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VETERANS MORTGAGE LIFE INSURANCE § 8a.4 Coverage. (a) The amount of VMLI in force on his or her life at any one time shall...

  19. 15 CFR 8b.4 - Discrimination prohibited.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Discrimination prohibited. 8b.4 Section 8b.4 Commerce and Foreign Trade Office of the Secretary of Commerce PROHIBITION OF DISCRIMINATION... Provisions § 8b.4 Discrimination prohibited. (a) General. No qualified handicapped individual shall, on...

  20. 15 CFR 8b.4 - Discrimination prohibited.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Discrimination prohibited. 8b.4 Section 8b.4 Commerce and Foreign Trade Office of the Secretary of Commerce PROHIBITION OF DISCRIMINATION... Provisions § 8b.4 Discrimination prohibited. (a) General. No qualified handicapped individual shall, on...

  1. 15 CFR 8b.4 - Discrimination prohibited.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Discrimination prohibited. 8b.4 Section 8b.4 Commerce and Foreign Trade Office of the Secretary of Commerce PROHIBITION OF DISCRIMINATION... Provisions § 8b.4 Discrimination prohibited. (a) General. No qualified handicapped individual shall, on...

  2. 15 CFR 8b.4 - Discrimination prohibited.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Discrimination prohibited. 8b.4 Section 8b.4 Commerce and Foreign Trade Office of the Secretary of Commerce PROHIBITION OF DISCRIMINATION... Provisions § 8b.4 Discrimination prohibited. (a) General. No qualified handicapped individual shall, on...

  3. 15 CFR 8b.4 - Discrimination prohibited.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Discrimination prohibited. 8b.4 Section 8b.4 Commerce and Foreign Trade Office of the Secretary of Commerce PROHIBITION OF DISCRIMINATION... Provisions § 8b.4 Discrimination prohibited. (a) General. No qualified handicapped individual shall, on...

  4. 1 CFR 8.4 - Indexes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Indexes. 8.4 Section 8.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.4 Indexes. A subject index to the entire Code shall be annually revised and...

  5. 1 CFR 8.4 - Indexes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Indexes. 8.4 Section 8.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.4 Indexes. A subject index to the entire Code shall be annually revised and...

  6. 1 CFR 8.4 - Indexes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Indexes. 8.4 Section 8.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.4 Indexes. A subject index to the entire Code shall be annually revised and...

  7. 43 CFR 8.4 - Blocking out.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Blocking out. 8.4 Section 8.4 Public Lands: Interior Office of the Secretary of the Interior JOINT POLICIES OF THE DEPARTMENTS OF THE INTERIOR AND OF THE ARMY RELATIVE TO RESERVOIR PROJECT LANDS § 8.4 Blocking out. Blocking out will be accomplished...

  8. 43 CFR 8.4 - Blocking out.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Blocking out. 8.4 Section 8.4 Public Lands: Interior Office of the Secretary of the Interior JOINT POLICIES OF THE DEPARTMENTS OF THE INTERIOR AND OF THE ARMY RELATIVE TO RESERVOIR PROJECT LANDS § 8.4 Blocking out. Blocking out will be accomplished...

  9. 43 CFR 8.4 - Blocking out.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Blocking out. 8.4 Section 8.4 Public Lands: Interior Office of the Secretary of the Interior JOINT POLICIES OF THE DEPARTMENTS OF THE INTERIOR AND OF THE ARMY RELATIVE TO RESERVOIR PROJECT LANDS § 8.4 Blocking out. Blocking out will be accomplished...

  10. 43 CFR 8.4 - Blocking out.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Blocking out. 8.4 Section 8.4 Public Lands: Interior Office of the Secretary of the Interior JOINT POLICIES OF THE DEPARTMENTS OF THE INTERIOR AND OF THE ARMY RELATIVE TO RESERVOIR PROJECT LANDS § 8.4 Blocking out. Blocking out will be accomplished...

  11. 43 CFR 8.4 - Blocking out.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Blocking out. 8.4 Section 8.4 Public Lands: Interior Office of the Secretary of the Interior JOINT POLICIES OF THE DEPARTMENTS OF THE INTERIOR AND OF THE ARMY RELATIVE TO RESERVOIR PROJECT LANDS § 8.4 Blocking out. Blocking out will be accomplished...

  12. 1 CFR 8.4 - Indexes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Indexes. 8.4 Section 8.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.4 Indexes. A subject index to the entire Code shall be annually revised and...

  13. 1 CFR 8.4 - Indexes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Indexes. 8.4 Section 8.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.4 Indexes. A subject index to the entire Code shall be annually revised and...

  14. Part I-the effects of pre-dissolved hydrogen on cleavage and grain boundary fracture initiation in metastable beta Ti-3Al-8V-6Cr-4Mo-4Zr

    NASA Astrophysics Data System (ADS)

    Gaudett, Michelle A.; Scully, John R.

    1999-01-01

    The effects of electrochemically pre-dissolved hydrogen on room-temperature fracture initiation in Beta-C titanium (Ti-3Al-8V-6Cr-4Mo-4Zr wt pct) have been investigated using circumferentially notched tensile specimens. Finite element-based analysis of notch stress fields was used to define relationships between the local threshold stress for crack initiation vs total internal hydrogen concentration. The as-received, solution heat treated (ST, σy.2 pct=865 MPa) and the ST + peak-aged conditions (STA, σ y.2% pct=1260 MPa) were compared after defining the relationships between the fracture process zone hydrogen concentration, hydrogen-metal interactions ( i.e., hydrostatic stress field occlusion, trapping, hydriding), and the resulting fracture initiation behavior of each. Solutionized + peak-aged ( β+α) Beta-C fractured intergranularly above total hydrogen concentrations of ˜1000 wt ppm. (5.1 at. pct). A fracture mode consistent with cleavage occurred at ˜2100 wt ppm. (10.7 at. pct). Solutionized Beta-C resisted hydrogen-assisted cracking ( e.g., did not crack intergranularly) but was not immune; cleavage cracking was provoked at ˜4000 wt ppm. (20.4 at. pct). Coldworked ST Beta-C (CW, σ y.2 pct=1107 MPa) did not crack intergranularly; fracture initiation behavior was similar to the ST condition regardless of specimen orientation. This suggests that high yield strength alone does not account for the susceptibility to intergranular cracking observed in the STA β+α condition. Stroke-rate studies and X-ray diffraction investigation of H partitioning suggests that equilibrium hydriding and/or irreversible trapping does not singularly control intergranular fracture initiation of the STA condition. Fractographic evidence and finite element results show that a finite plastic zone exists prior to intergranular fracture of the STA condition. This suggests that a criterion for fracture that incorporates plastic strain and stress should be considered.

  15. 2,4,6-Trichlorophenol

    Integrated Risk Information System (IRIS)

    2,4,6 - Trichlorophenol ; CASRN 88 - 06 - 2 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcino

  16. Hydrothermal synthesis, crystal structure, and magnetic properties of a novel organo-templated iron(III) borophosphate: (C{sub 3}H{sub 12}N{sub 2})Fe{sup III} {sub 6}(H{sub 2}O){sub 4}[B{sub 4}P{sub 8}O{sub 32}(OH){sub 8}

    SciTech Connect

    Huang Yaxi; Schnelle, Walter; Zhang Hui; Borrmann, Horst; Kniep, Ruediger

    2009-04-15

    The organo-templated iron(III) borophosphate (C{sub 3}H{sub 12}N{sub 2})Fe{sup III} {sub 6}(H{sub 2}O){sub 4}[B{sub 4}P{sub 8}O{sub 32}(OH){sub 8}] was prepared under mild hydrothermal conditions (at 443 K) and the crystal structure was determined from single crystal X-ray data at 295 K (monoclinic, P2{sub 1}/c (No. 14), a=5.014(2) A, b=9.309(2) A, c=20.923(7) A, beta=110.29(2){sup o}, V=915.9(5) A{sup 3}, Z=2, R1=0.049, wR2=0.107 for all data, 2234 observed reflections with I>2sigma(I)). The title compound contains a complex inorganic framework of borophosphate trimers [BP{sub 2}O{sub 8}(OH){sub 2}]{sup 5-} together with FeO{sub 4}(OH)(H{sub 2}O)- and FeO{sub 4}(OH){sub 2}-octahedra forming channels with ten-membered ring apertures in which the diaminopropane cations are located. The magnetization measurements confirm the Fe(III)-state and show an antiferromagnetic ordering at T{sub N}{approx}14.0(1) K. - Graphical abstract: The complex inorganic open-framework of (C{sub 3}H{sub 12}N{sub 2})Fe{sup III} {sub 6}(H{sub 2}O){sub 4}[B{sub 4}P{sub 8}O{sub 32}(OH){sub 8}] consists of borophosphate trimers and iron(III) coordination octahedra arranged to form channels with ten-membered ring apertures in which the organic 1,3-diaminopropane cations are located.

  17. Superstructure formation in SrBa8[BN2]6 and EuBa8[BN2]6.

    PubMed

    Seidel, Stefan; Dierkes, Tobias; Jüstel, Thomas; Benndorf, Christopher; Eckert, Hellmut; Pöttgen, Rainer

    2016-07-26

    X-ray pure samples of SrBa8[BN2]6 and EuBa8[BN2]6 were synthesized from appropriate amounts of binary nitrides (Sr3N2, Ba3N2 and BN in sealed niobium ampoules and EuN, Ba3N2 and BN in BN crucibles, respectively) at temperatures up to 1370 K. The structure of SrBa8[BN2]6 was refined from single crystal X-ray diffractometer data: Fd3[combining macron]m, a = 1595.1(1) pm, wR(F(2)) = 0.0515, 387 F(2) values and 21 variables. EuBa8[BN2]6 has a lattice parameter of 1595.00(9) pm. Both nitridoborates adopt a new 2 × 2 × 2 superstructure variant of the LiCa4[BN2]3 type, realized through ordering of vacancies and Sr(2+) and Eu(2+) cations, respectively. The structures of SrBa8[BN2]6 and LiCa4[BN2]3 are related by a group-subgroup scheme. The Sr(2+)/vacancy ordering leads to an asymmetric coordination (1 × Sr(2+) and 8 × Ba(2+) in a distorted, mono-capped square prism) for the [BN2](3-) units with B-N distances of 132 and 136 pm. Vibrational spectra of SrBa8[BN2]6 and EuBa8[BN2]6 confirm the discrete linear [BN2](3-) units and (11)B solid state MAS NMR spectra are compatible with single crystallographic sites for the boron atoms. In EuBa8[BN2]6 the spectra are profoundly influenced by interactions of the (11)B nuclei with the unpaired electrons of the paramagnetic Eu(2+) ions. PMID:27397545

  18. Superstructure formation in SrBa8[BN2]6 and EuBa8[BN2]6.

    PubMed

    Seidel, Stefan; Dierkes, Tobias; Jüstel, Thomas; Benndorf, Christopher; Eckert, Hellmut; Pöttgen, Rainer

    2016-07-26

    X-ray pure samples of SrBa8[BN2]6 and EuBa8[BN2]6 were synthesized from appropriate amounts of binary nitrides (Sr3N2, Ba3N2 and BN in sealed niobium ampoules and EuN, Ba3N2 and BN in BN crucibles, respectively) at temperatures up to 1370 K. The structure of SrBa8[BN2]6 was refined from single crystal X-ray diffractometer data: Fd3[combining macron]m, a = 1595.1(1) pm, wR(F(2)) = 0.0515, 387 F(2) values and 21 variables. EuBa8[BN2]6 has a lattice parameter of 1595.00(9) pm. Both nitridoborates adopt a new 2 × 2 × 2 superstructure variant of the LiCa4[BN2]3 type, realized through ordering of vacancies and Sr(2+) and Eu(2+) cations, respectively. The structures of SrBa8[BN2]6 and LiCa4[BN2]3 are related by a group-subgroup scheme. The Sr(2+)/vacancy ordering leads to an asymmetric coordination (1 × Sr(2+) and 8 × Ba(2+) in a distorted, mono-capped square prism) for the [BN2](3-) units with B-N distances of 132 and 136 pm. Vibrational spectra of SrBa8[BN2]6 and EuBa8[BN2]6 confirm the discrete linear [BN2](3-) units and (11)B solid state MAS NMR spectra are compatible with single crystallographic sites for the boron atoms. In EuBa8[BN2]6 the spectra are profoundly influenced by interactions of the (11)B nuclei with the unpaired electrons of the paramagnetic Eu(2+) ions.

  19. 8 CFR 1287.4 - Subpoena.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... records and evidence for use in criminal or civil investigations, see 8 CFR 287.4(a)(1). (2) Proceedings... evidence, or both, for use in any proceeding under this title, other than under 8 CFR part 335, or any application made ancillary to the proceeding, see 8 CFR 287.4(a)(2)(i). (ii) Subsequent to commencement of...

  20. 8 CFR 1292.4 - Appearances.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Appearances. 1292.4 Section 1292.4 Aliens... otherwise provided in § 103.2(b) of 8 CFR chapter I, a party to a proceeding or his attorney or... with § 103.10 of 8 CFR chapter I, obtain copies of Service records or information therefrom and...

  1. Fused Perovskite Tunnel Structures in Ba5 Fe6+x S4+x O8 (0.44≤x≤0.55) with x-Dependent Two-Stage Magnetizations.

    PubMed

    Wright, Taylor; Prots, Yurii; Valldor, Martin

    2016-08-01

    Ba5 Fe6+x S4+x O8 was synthesized through a solid-state reaction, and pure powders of nominal compositions x=0.44-0.55 were obtained after being rinsed with water. The crystal structures (P4/mmm, a=10.13, c=4.03 Å) and sample purities were investigated by powder synchrotron X-ray diffraction and were found to be composed of a tunnel lattice (Ba5 Fe6 S4 O8 ), built from fused perovskite units and the tunnel filling (Fex Sx ). The variable composition, that is, the tunnel filling (x), causes partially occupied sites as well as crystallographic split positions. Ba5 Fe6+x S4+x O8 (x=0.525) is semiconducting and all investigated compositions exhibit magnetic ground states that could be described as either semi-spin-glass-like (x>0.5) or canted antiferromagnetic (x<0.5). The spin-glass in x=0.525 exhibits magnetic relaxations that are affected by ageing. PMID:27359247

  2. Fused Perovskite Tunnel Structures in Ba5 Fe6+x S4+x O8 (0.44≤x≤0.55) with x-Dependent Two-Stage Magnetizations.

    PubMed

    Wright, Taylor; Prots, Yurii; Valldor, Martin

    2016-08-01

    Ba5 Fe6+x S4+x O8 was synthesized through a solid-state reaction, and pure powders of nominal compositions x=0.44-0.55 were obtained after being rinsed with water. The crystal structures (P4/mmm, a=10.13, c=4.03 Å) and sample purities were investigated by powder synchrotron X-ray diffraction and were found to be composed of a tunnel lattice (Ba5 Fe6 S4 O8 ), built from fused perovskite units and the tunnel filling (Fex Sx ). The variable composition, that is, the tunnel filling (x), causes partially occupied sites as well as crystallographic split positions. Ba5 Fe6+x S4+x O8 (x=0.525) is semiconducting and all investigated compositions exhibit magnetic ground states that could be described as either semi-spin-glass-like (x>0.5) or canted antiferromagnetic (x<0.5). The spin-glass in x=0.525 exhibits magnetic relaxations that are affected by ageing.

  3. 6-Allyl-8-meth­oxy-3-phenyl-3,4-dihydro-2H-benzo[e][1,3]oxazine

    PubMed Central

    Zhu, Jing; Ren, Zhi-Dong; Liu, Yang; Zhao, Lei; Wu, Yong

    2011-01-01

    In the title compound, C18H19NO2, the allyl group is disordered over two sets of sites [occupancy ratio 0.662 (4):0.338 (4)]. The dihedral angle between the phenyl and benzene rings is 87.44 (10)°. The oxazinane ring adopts a sofa conformation. PMID:22091082

  4. (+)-2-(1,2,3,4,4a,5,6,7-Octahydro-4a,8-dimethyl-7-oxo-2-naphthyl)propionic acid: catemeric hydrogen bonding in a bicyclic sesquiterpenoid keto acid.

    PubMed

    Brunskill, Andrew P J; Thompson, Hugh W; Lalancette, Roger A

    2002-05-01

    The title compound, C(15)H(22)O(3), derived from a naturally occurring sesquiterpenoid, has two molecules in the asymmetric unit, differing principally in the rotational conformation of the carboxyl group. Each species aggregates separately as a carboxyl-to-ketone hydrogen-bonding catemer [O.O = 2.752 (4) and 2.682 (4) A, and O-H.O = 161 (4) and 168 (4) degrees ], producing two crystallographically independent single-strand hydrogen-bonding helices, with opposite end-to-end orientations, passing through the cell in the b direction. Three intermolecular C-H.O=C close contacts exist for the ketone. PMID:11983981

  5. Color-tunable photoluminescence phosphors of Ce3+ and Tb3+ co-doped Sr2La8(SiO4)6O2 for UV w-LEDs

    NASA Astrophysics Data System (ADS)

    Guo, Qingfeng; Liao, Libing; Mei, Lefu; Liu, Haikun; Hai, Yun

    2015-05-01

    A series of new luminescent emission-tunable phosphors Sr2La8(SiO4)6O2:Ce3+, Tb3+ with apatite structure have been synthesized by a high temperature solid-state reaction. The phase structure, photoluminescence emission and excitation spectra, lifetime, as well as the effect of Tb3+ concentration are investigated to characterize the resulting samples. The critical distance was calculated to be 8.26 Å by using the concentration quenching method. The intense green emission was observed in the Sr2La8(SiO4)6O2:Ce3+, Tb3+ phosphors on the basis of the efficient energy transfer from Ce3+ to Tb3+ with an efficiency of 68.55%. And a possible mechanism of the energy-transfer from Ce3+ to Tb3+ ion is also proposed. The results indicate that Sr2La8(SiO4)6O2:Ce3+, Tb3+ phosphors have potential applications to be used as near UV-convertible phosphors for white light-emitting diodes because of the broad excitation in the near-ultraviolet range and the efficient green emission light.

  6. 15 CFR 4.8 - Classified Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Classified Information. 4.8 Section 4... INFORMATION Freedom of Information Act § 4.8 Classified Information. In processing a request for information..., the information shall be reviewed to determine whether it should remain classified. Ordinarily...

  7. Synthesis, characterization, thermal behaviour and single crystal X-ray analysis of two new insensitive high energy density materials [8-hydroxyquinolinium 5-(2,4,6-trinitrophenyl)barbiturate (I) and 8-hydroxyquinolinium 5-(5-chloro-2,4-dinitrophenyl)-1,3-dimethyl barbiturate (II)

    NASA Astrophysics Data System (ADS)

    Manickkam, V.; Devi, P. Poornima; Kalaivani, D.

    2014-12-01

    Barbiturates I and II have been synthesized as maroon red and red orange coloured solids by mixing the ethanolic solutions of 2-chloro-1,3,5-trinitrobenzene ( TNCB), pyrimidine-2,4,6(1 H,3 H,5 H)-trione [barbituric acid ( BA)] and 8-hydroxyquinoline and 1,3-dichloro-4,6-dinitrobenzene ( DCDNB), 1,3-dimethylpyrimidine-2,4,6(1 H,3 H,5 H)-trione(1,3-dimethylbarbituric acid) and 8-hydroxyquinoline respectively. The structures of these two barbiturates have been predicted from the spectral studies (UV-VIS, IR, 1H NMR, 13C NMR, mass) and elemental analysis. Qualitative tests have been carried out to infer the presence of nitrogen and nitro groups and also chlorine atom in barbiturate II. Slow evaporation of ethanol-dimethylsulphoxide/ethanol solutions of barbiturate I/barbiturate II at 293 K yielded good for X-Ray diffraction crystals. Single crystal X-ray diffraction studies of the crystals further confirm the putative structures of the barbiturates. The asymmetric unit of the barbiturate I comprises of 8-hydroxyquinolinium cation, 5-(2,4,6-trinitrophenyl) barbiturate anion and a molecule of dimethylsulphoxide (DMSO), which is used as a recrystallizing solvent. It crystallizes in the triclinic system with space group (centrosymmetric). Barbiturate II crystallizes in the orthorhombic system with space group P212121 (non-centrosymmetric). Barbiturates I and II are stable towards an impact sensitivity test, when a weight of 2 kg mass hammer is dropped from a height of 160 cm of the instrument. TGA/ DTA analyses at four different heating rates (5, 10, 20, and 40 K/min) imply that they undergo exothermic decomposition (˜85%) in three different stages between 273 and 873 K. Activation energies for these decomposition processes have been calculated by employing Kissinger and Ozawa plots. Impact sensitivity test and activation energies have revealed that the titled barbiturates are insensitive high energy density materials ( IHEDMS).

  8. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  9. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  10. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  11. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  12. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9-bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  13. Synthesis and evaluation of antitumor activity of 2- and 6-[(1,3-benzothiazol-2-yl)aminomethyl]-5,8-dimethoxy-1,4-naphthoquinone derivatives.

    PubMed

    Chung, Yongseog; Shin, Young-Kook; Zhan, Chang-Guo; Lee, Sungduck; Cho, Hoon

    2004-09-01

    2- or 6-substituted BZT-N derivatives were synthesized, and their cytotoxic activity against cancer L1210 and SNU-1 cells was examined. The antitumor action was also assessed in mice bearing S-180 cells in peritoneal cavity. In a comparison, it was found that 6-substituted BZT-N derivatives exhibited higher potencies in both bioactivities than 2-substituted BZT-N derivatives against L1210 cells in in vitro and S-180 in vitro tests exception of compound 36. Interestingly, it was observed that 2-substituted compound 36, which has methyl group at R1 position, exhibited a better antitumor activity than 6-substituted compounds against L1210 and SNU-1 in vitro. The ED50 value of 2-substituted compound 36 against L1210 was found to be comparable to the ED50 value of adriamycin and was even better against the solid cancer cell line SNU-1. It was also observed that 2-substituted compound 36 showed better antitumor activity in mice bearing S-180 cells in the peritoneal cavity. The T/C (%) value of 2-substituted compound 36 was similar to that of adriamycin. Quantitative structure-activity relationship (QSAR) tests reveal that the experimental ED50 values against SNU-1 closely correlate with both the calculated HOMO energies (E(HOMO)) and the measured 1H-NMR chemical shift of 3-H (deltaH). The results suggests that a compound having higher E(HOMO) and deltaH values usually should have a lower ED50 (SNU-1) value.

  14. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... States, as defined in section 203(b)(5)(C)(iii) of the Act, is one million United States dollars ($1,000... meet the criteria set forth in 8 CFR 204.6(j)(4)(ii). (i) State designation of a high unemployment area. The state government of any state of the United States may designate a particular......

  15. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... States, as defined in section 203(b)(5)(C)(iii) of the Act, is one million United States dollars ($1,000... meet the criteria set forth in 8 CFR 204.6(j)(4)(ii). (i) State designation of a high unemployment area. The state government of any state of the United States may designate a particular......

  16. The People of South Asia [Grades 6-8].

    ERIC Educational Resources Information Center

    Adams, George; And Others

    A resource book for grades 6-8 contains materials to enrich a unit on South Asia. Material is divided into 13 sections. Sections 1-4 outline the rationale, goals, and objectives of the unit. Emphasis is placed on providing background for the understanding of South Asian cultural groups in the United States. Ten objectives are listed, including the…

  17. 6,7,8,9-Tetra-hydro-4b,9b-dihy-droxy-indano[1,2-b]indoline-9,10-dione monohydrate.

    PubMed

    Yaqub, Muhammad; Mahmood, Khalid; Tahir, M Nawaz; Shafiq, Zahid; Rauf, Abdul

    2010-07-03

    In the title compound, C(15)H(13)NO(4)·H(2)O, the organic mol-ecule adopts a V-shaped conformation in which the dihedral angle between the five-membered rings is 68.33 (5)°. The cyclo-hexenone ring adopts an envelope conformation, with one of the methyl-ene C atoms displaced by 0.607 (4) Å from the plane through the other atoms. In the crystal, inter-molecular N-H⋯(O,O) and O-H⋯O hydrogen bonds link the components into (001) sheeets and C-H⋯O inter-actions and aromatic π-π stacking [centroid-centroid separation = 3.6176 (19) Å] help to consolidate the packing.

  18. Corner sharing tetrahedral network in Co(3)(HAT)[N(CN)(2)](6)(OH(2))(2) (HAT = 1,4,5,8,9,12-hexaazatriphenylene).

    PubMed

    Marshall, Shireen R; Rheingold, Arnold L; Dawe, Louise N; Shum, William W; Kitamura, Chitoshi; Miller, Joel S

    2002-07-15

    We report a trinuclear Co(II) complex containing bridging dicyanamides and a tris-chelated HAT, which possesses approximately 37% void space. The magnetic exchange pathways appear in the structure as a corner sharing tetrahedral network. The compound crystallizes in the monoclinic space group P2(1)/c [a = 13.655(3) A, b = 15.189(3) A, c = 22.367(4) A, beta = 114.100(2) degrees, V = 4234.5(14) A(3), Z = 4, R(F(o)) = 0.0823]. The magnetic data were fit to an S = 3/2 model for systems dominated by zero-field splitting effects with g = 2.01 and D = 38.9 cm(-1). PMID:12099860

  19. Replication Bypass of the trans-4-Hydroxynonenal-Derived (6S,8R,11S)-1,N[superscript 2]-Deoxyguanosine DNA Adduct by the Sulfolobus solfataricus DNA Polymerase IV

    SciTech Connect

    Banerjee, Surajit; Christov, Plamen P.; Kozekova, Albena; Rizzo, Carmelo J.; Egli, Martin; Stone, Michael P.

    2014-10-02

    trans-4-Hydroxynonenal (HNE) is the major peroxidation product of {omega}-6 polyunsaturated fatty acids in vivo. Michael addition of the N{sub 2}-amino group of dGuo to HNE followed by ring closure of N1 onto the aldehyde results in four diastereomeric 1,N{sub 2}-dGuo (1,N{sub 2}-HNE-dGuo) adducts. The (6S,8R,11S)-HNE-1,N{sub 2}-dGuo adduct was incorporated into the 18-mer templates 5'-d(TCATXGAATCCTTCCCCC)-3' and d(TCACXGAATCCTTCCCCC)-3', where X = (6S,8R,11S)-HNE-1,N{sub 2}-dGuo adduct. These differed in the identity of the template 5'-neighbor base, which was either Thy or Cyt, respectively. Each of these templates was annealed with either a 13-mer primer 5'-d(GGGGGAAGGATTC)-3' or a 14-mer primer 5'-d(GGGGGAAGGATTCC)-3'. The addition of dNTPs to the 13-mer primer allowed analysis of dNTP insertion opposite to the (6S,8R,11S)-HNE-1,N{sub 2}-dGuo adduct, whereas the 14-mer primer allowed analysis of dNTP extension past a primed (6S,8R,11S)-HNE-1,N{sub 2}-dGuo:dCyd pair. The Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) belongs to the Y-family of error-prone polymerases. Replication bypass studies in vitro reveal that this polymerase inserted dNTPs opposite the (6S,8R,11S)-HNE-1,N{sub 2}-dGuo adduct in a sequence-specific manner. If the template 5'-neighbor base was dCyt, the polymerase inserted primarily dGTP, whereas if the template 5'-neighbor base was dThy, the polymerase inserted primarily dATP. The latter event would predict low levels of Gua {yields} Thy mutations during replication bypass when the template 5'-neighbor base is dThy. When presented with a primed (6S,8R,11S)-HNE-1,N{sub 2}-dGuo:dCyd pair, the polymerase conducted full-length primer extension. Structures for ternary (Dpo4-DNA-dNTP) complexes with all four template-primers were obtained. For the 18-mer:13-mer template-primers in which the polymerase was confronted with the (6S,8R,11S)-HNE-1,N{sub 2}-dGuo adduct, the (6S,8R,11S)-1,N{sub 2}-dGuo lesion remained in the ring

  20. 5-(4-Chloro­phen­yl)-1-methyl-3-phenyl-3,6,8,9-tetra­hydro­pyrazolo­[3,4-b]thio­pyrano[4,3-d]pyridine

    PubMed Central

    Jia, Runhong; Peng, Juhua

    2011-01-01

    The title compound, C22H18ClN3S, was synthesized by the reaction of 4-chloro­benzaldehyde, tetra­hydro­thio­pyran-4-one and 3-methyl-1-phenyl-1H-pyrazol-5-amine in acetic acid without a catalyst. The pyridine and pyrazole rings are almost coplanar, the dihedral angle between their mean planes being 2.50 (1)°. The thio­pyran ring exhibits an envelope conformation. The crystal packing is stabilized by inter­molecular C—H⋯Cl hydrogen bonds and by C—H⋯π and π–π inter­actions [centroid–centroid distances of 3.825 (2) Å between pyridine rings and 3.557 (2) Å between pyrazole and pyridine rings. PMID:22059005

  1. Wear studies on plasma-sprayed Al2O3 and 8mole% of Yttrium-stabilized ZrO2 composite coating on biomedical Ti-6Al-4V alloy for orthopedic joint application.

    PubMed

    Ganapathy, Perumal; Manivasagam, Geetha; Rajamanickam, Asokamani; Natarajan, Alagumurthi

    2015-01-01

    This paper presents the wear characteristics of the composite ceramic coating made with Al2O3-40wt%8YSZ on the biomedical grade Ti-6Al-4V alloy (grade 5) used for total joint prosthetic components, with the aim of improving their tribological behavior. The coatings were deposited using a plasma spraying technique, and optimization of plasma parameters was performed using response surface methodology to obtain dense coating. The tribological behaviors of the coated and uncoated substrates were evaluated using a ball-on-plate sliding wear tester at 37°C in simulated body-fluid conditions. The microstructure of both the titanium alloy and coated specimen were examined using an optical microscope and scanning electron microscope. The hardness of the plasma-sprayed alumina-zirconia composite coatings was 2.5 times higher than that of the Ti-6Al-4V alloy, while the wear rate of Ti-6Al-4V alloy was 253 times higher than that of the composite-coated Ti-6Al-4V alloy. The superior wear resistance of the alumina-zirconia coated alloy is attributed to its enhanced hardness and intersplat bonding strength. Wear-track examination showed that the predominant wear mechanism of Ti-6Al-4V alloy was abrasive and adhesive wear, whereas, in the case of alumina-zirconia composite coated alloy, the wear was dominated by microchipping and microcracking.

  2. Wear studies on plasma-sprayed Al2O3 and 8mole% of Yttrium-stabilized ZrO2 composite coating on biomedical Ti-6Al-4V alloy for orthopedic joint application.

    PubMed

    Ganapathy, Perumal; Manivasagam, Geetha; Rajamanickam, Asokamani; Natarajan, Alagumurthi

    2015-01-01

    This paper presents the wear characteristics of the composite ceramic coating made with Al2O3-40wt%8YSZ on the biomedical grade Ti-6Al-4V alloy (grade 5) used for total joint prosthetic components, with the aim of improving their tribological behavior. The coatings were deposited using a plasma spraying technique, and optimization of plasma parameters was performed using response surface methodology to obtain dense coating. The tribological behaviors of the coated and uncoated substrates were evaluated using a ball-on-plate sliding wear tester at 37°C in simulated body-fluid conditions. The microstructure of both the titanium alloy and coated specimen were examined using an optical microscope and scanning electron microscope. The hardness of the plasma-sprayed alumina-zirconia composite coatings was 2.5 times higher than that of the Ti-6Al-4V alloy, while the wear rate of Ti-6Al-4V alloy was 253 times higher than that of the composite-coated Ti-6Al-4V alloy. The superior wear resistance of the alumina-zirconia coated alloy is attributed to its enhanced hardness and intersplat bonding strength. Wear-track examination showed that the predominant wear mechanism of Ti-6Al-4V alloy was abrasive and adhesive wear, whereas, in the case of alumina-zirconia composite coated alloy, the wear was dominated by microchipping and microcracking. PMID:26491323

  3. Wear studies on plasma-sprayed Al2O3 and 8mole% of Yttrium-stabilized ZrO2 composite coating on biomedical Ti-6Al-4V alloy for orthopedic joint application

    PubMed Central

    Ganapathy, Perumal; Manivasagam, Geetha; Rajamanickam, Asokamani; Natarajan, Alagumurthi

    2015-01-01

    This paper presents the wear characteristics of the composite ceramic coating made with Al2O3-40wt%8YSZ on the biomedical grade Ti-6Al-4V alloy (grade 5) used for total joint prosthetic components, with the aim of improving their tribological behavior. The coatings were deposited using a plasma spraying technique, and optimization of plasma parameters was performed using response surface methodology to obtain dense coating. The tribological behaviors of the coated and uncoated substrates were evaluated using a ball-on-plate sliding wear tester at 37°C in simulated body-fluid conditions. The microstructure of both the titanium alloy and coated specimen were examined using an optical microscope and scanning electron microscope. The hardness of the plasma-sprayed alumina–zirconia composite coatings was 2.5 times higher than that of the Ti-6Al-4V alloy, while the wear rate of Ti-6Al-4V alloy was 253 times higher than that of the composite-coated Ti-6Al-4V alloy. The superior wear resistance of the alumina–zirconia coated alloy is attributed to its enhanced hardness and intersplat bonding strength. Wear-track examination showed that the predominant wear mechanism of Ti-6Al-4V alloy was abrasive and adhesive wear, whereas, in the case of alumina–zirconia composite coated alloy, the wear was dominated by microchipping and microcracking. PMID:26491323

  4. Correlation between superconductivity and structural properties under high pressure of iron pnictide superconductor Ce[subscript 0.6]Y[subscript 0.4]FeAsO[subscript 0.8]F[subscript 0.2

    SciTech Connect

    Kanagaraj, M.; Arumugam, S.; Kumar, Ravhi S.; Selvan, N.R. Tamil; Muthu, S. Esakki; Prakash, J.; Thakur, Gohil S.; Yoshino, H.; Murata, K.; Matsubayashi, K.; Uwatoko, Y.; Sinogeikin, S.; Cornelius, Andrew; Ganguli, A.K.; Zhao, Yusheng

    2012-02-28

    We report here the pressure dependence of the electrical resistivity and magnetic susceptibility of polycrystalline Ce{sub 0.6}Y{sub 0.4}FeAsO{sub 0.8}F{sub 0.2} superconductor in the temperature range 4 K to 300 K up to 8 GPa. In-situ high pressure-low temperature x-ray diffraction was performed at 8 K up to 32 GPa using synchrotron x-rays with helium pressure medium. The results show that the applied pressure slightly increases the T{sub c} up to 1 GPa and then it decreases on further pressure increase. The reduction of superconducting transition temperature occurs with a transition to a collapsed tetragonal phase and may be associated with a possible valence change of Ce.

  5. 4 CFR 201.8 - Fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Fees. 201.8 Section 201.8 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PUBLIC INFORMATION AND REQUESTS § 201.8 Fees. (a) General. The Board shall...—A request from, or on behalf of, a person who seeks information for a purpose that furthers...

  6. 4 CFR 201.8 - Fees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 4 Accounts 1 2012-01-01 2012-01-01 false Fees. 201.8 Section 201.8 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PUBLIC INFORMATION AND REQUESTS § 201.8 Fees. (a) General. The Board shall charge for processing requests under the FOIA in accordance with paragraph (c) of this section,...

  7. Comparison of Energetic Electron Distribution Functions Derived from CXDs (L~4.2), CPAs and SOPAs (L~6.6), and Model AE8 at or near the Magnetic Equator

    NASA Astrophysics Data System (ADS)

    Cayton, T. E.; Denton, M.; Borovsky, J.; Belian, R. D.; Christensen, R. A.; Ingraham, J. C.

    2015-12-01

    Throughout the range of L-shells important for GPS and GEO spacecraft (4.28 is represented very well by a sum of 3 exponential components, soft, hard, and tail, each parameterized by a temperature and a density. Furthermore, the 3 temperatures vary only slightly over this range of L-shells suggesting an almost isothermal electron population. Indeed, for AE8, the temperatures of the soft and hard populations actually decrease with decreasing L. The event-dominated and non-event-dominated natures of time variations on L-shells observed by GPS and GEO, respectively, underlie this paradox.1 At one end of the L range, and consistent with AE8, in situ measurements (averaged for several minutes or more) from GEO spacecraft are represented well by sums of 3 exponential components, and individual spectra resemble their average. At the lower end of the L range, however, individual CXD spectra exhibit characteristic non-equilibrium leakage features,2and they bear little resemblance to their average. Local-time asymmetries develop at L=4.2 during event decay phases that follow electron injections; 0.3 MeV electrons exhibit the largest asymmetries on these L-shells. When a 14-day-long averaging interval (sets of 14 individual CXD spectra with similar magnetic-equator-crossing coordinates) includes one or more electron injections, the energy dependence of the average spectra often resemble sums of 3 exponential components, consistent with the model based on average fluxes, AE8.1.) K. W. Chan, M. J. Teague, N. J. Schofield, and J. I. Vette, "Modeling of Electron Time Variations in the Radiation Belts," Quantitative Modeling of Magnetospheric Processes, W. P. Olson, ed., AGU, Washington D.C., 1979, p. 147. 2.) J. J. Duderstadt and L. J. Hamilton, Nuclear Reactor Analysis, John Wiley, New York, 1976, pp.381-383.

  8. 8 CFR 244.6 - Application.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... that announces the procedures for TPS registration or re-registration, and 8 CFR 103.2, except as... CFR 103.7(b)(1), 103.16, and 103.17. (b) An applicant for TPS may also request employment authorization pursuant to 8 CFR 274a. Those applicants between the ages of 14 and 65 who are not...

  9. 8 CFR 244.6 - Application.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... that announces the procedures for TPS registration or re-registration, and 8 CFR 103.2, except as... CFR 103.7(b)(1), 103.16, and 103.17. (b) An applicant for TPS may also request employment authorization pursuant to 8 CFR 274a. Those applicants between the ages of 14 and 65 who are not...

  10. 8 CFR 244.6 - Application.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... that announces the procedures for TPS registration or re-registration, and 8 CFR 103.2, except as... CFR 103.7(b)(1), 103.16, and 103.17. (b) An applicant for TPS may also request employment authorization pursuant to 8 CFR 274a. Those applicants between the ages of 14 and 65 who are not...

  11. 15 CFR 8.4 - Discrimination prohibited.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Discrimination prohibited. 8.4 Section... General Provisions; Prohibitions: Nondiscrimination Clause; Applicability to Programs § 8.4 Discrimination... discrimination under, any program to which this part applies. (b) Specific discriminatory acts prohibited. (1)...

  12. 15 CFR 8.4 - Discrimination prohibited.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Discrimination prohibited. 8.4 Section... General Provisions; Prohibitions: Nondiscrimination Clause; Applicability to Programs § 8.4 Discrimination... discrimination under, any program to which this part applies. (b) Specific discriminatory acts prohibited. (1)...

  13. 24 CFR 8.4 - Discrimination prohibited.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Discrimination prohibited. 8.4... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT General Provisions § 8.4 Discrimination prohibited. (a) No... in, be denied the benefits of, or otherwise be subjected to discrimination under any program...

  14. 24 CFR 8.4 - Discrimination prohibited.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discrimination prohibited. 8.4... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT General Provisions § 8.4 Discrimination prohibited. (a) No... in, be denied the benefits of, or otherwise be subjected to discrimination under any program...

  15. 24 CFR 8.4 - Discrimination prohibited.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Discrimination prohibited. 8.4... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT General Provisions § 8.4 Discrimination prohibited. (a) No... in, be denied the benefits of, or otherwise be subjected to discrimination under any program...

  16. 15 CFR 8.4 - Discrimination prohibited.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Discrimination prohibited. 8.4 Section... General Provisions; Prohibitions: Nondiscrimination Clause; Applicability to Programs § 8.4 Discrimination... discrimination under, any program to which this part applies. (b) Specific discriminatory acts prohibited. (1)...

  17. 24 CFR 8.4 - Discrimination prohibited.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Discrimination prohibited. 8.4... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT General Provisions § 8.4 Discrimination prohibited. (a) No... in, be denied the benefits of, or otherwise be subjected to discrimination under any program...

  18. 24 CFR 8.4 - Discrimination prohibited.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Discrimination prohibited. 8.4... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT General Provisions § 8.4 Discrimination prohibited. (a) No... in, be denied the benefits of, or otherwise be subjected to discrimination under any program...

  19. 15 CFR 8.4 - Discrimination prohibited.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Discrimination prohibited. 8.4 Section... General Provisions; Prohibitions: Nondiscrimination Clause; Applicability to Programs § 8.4 Discrimination... discrimination under, any program to which this part applies. (b) Specific discriminatory acts prohibited. (1)...

  20. 15 CFR 8.4 - Discrimination prohibited.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Discrimination prohibited. 8.4 Section... General Provisions; Prohibitions: Nondiscrimination Clause; Applicability to Programs § 8.4 Discrimination... discrimination under, any program to which this part applies. (b) Specific discriminatory acts prohibited. (1)...

  1. 27 CFR 8.4 - Jurisdictional limits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Jurisdictional limits. 8.4 Section 8.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF...) The direct effect of the requirement is to prevent, deter, hinder, or restrict other persons...

  2. High-performance symmetric sodium-ion batteries using a new, bipolar O3-type material, Na 0.8 Ni 0.4 Ti 0.6 O 2

    SciTech Connect

    Guo, Shaohua; Yu, Haijun; Liu, Pan; Ren, Yang; Zhang, Tao; Chen, Mingwei; Ishida, Masayoshi; Zhou, Haoshen

    2015-01-01

    Based on low-cost and rich resources, sodium-ion batteries have been regarded as a promising candidate for next-generation energy storage batteries in the large-scale energy applications of renewable energy and smart grids. However, there are some critical drawbacks limiting its application, such as safety and stability problems. In this work, a stable symmetric sodium-ion battery based on the bipolar, active O3-type material, Na0.8Ni0.4Ti0.6O2, is developed. This bipolar material shows a typical O3-type layered structure, containing two electrochemically active transition metals with redox couples of Ni4+/Ni2+ and Ti4+/Ti3+, respectively. This Na0.8Ni0.4Ti0.6O2-based symmetric cell exhibits a high average voltage of 2.8 V, a reversible discharge capacity of 85 mA h g(-1), 75% capacity retention after 150 cycles and good rate capability. This full symmetric cell will greatly contribute to the development of room-temperature sodium-ion batteries with a view towards safety, low cost and long life, and it will stimulate further research on symmetric cells using the same active materials as both cathode and anode.

  3. SAPHIRE 8 Volume 6 - Quality Assurance

    SciTech Connect

    C. L. Smith; R. Nims; K. J. Kvarfordt

    2011-03-01

    The Systems Analysis Programs for Hands-on Integrated Reliability Evaluations (SAPHIRE) Version 8 is a software application developed for performing a complete probabilistic risk assessment using a personal computer running the Microsoft Windows™ operating system. SAPHIRE 8 is funded by the U.S. Nuclear Regulatory Commission (NRC). The role of the INL in this project is that of software developer and tester. This development takes place using formal software development procedures and is subject to quality assurance (QA) processes. The purpose of this document is to describe how the SAPHIRE software QA is performed for Version 8, what constitutes its parts, and limitations of those processes. In addition, this document describes the Independent Verification and Validation that was conducted for Version 8 as part of an overall QA process.

  4. 36 CFR 8.6 - Complaints; appeal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Appeals Procedures, 43 CFR part 4, subpart B, and the special procedural rules in subpart G of 43 CFR part 4, applicable to proceedings in appeals cases which do not lie within the appellate jurisdiction...

  5. [Synthesis of stable solvates of monosodium 2-[R*s,9S*)-(4-methoxy-6,7,8, 9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)sulfinyl]-1H-benzimidazole].

    PubMed

    Yamada, S; Goto, T; Yuasa, S; Yamaguchi, T; Kogi, K

    1996-08-01

    Monosodium 2-[(R*s,9S*)-(4-methoxy-6,7,8, 9-tetrahydro-5H-cyclohepta-[b]pyridin-9-yl)sulfinyl]-1H-benzimidazole (3A), a novel antiulcer agent previously reported by us, was found to be easily decomposed in weakly acidic solutions. In order to improve the stability of the parent compound, 3A, the preparation of 1-substituted benzimidazoles (4A) was attempted. However, the inhibitory effect of 4A against gastric acid secretion was less potent than that of 3A. Then 3A was solvated by EtOH or H2O to afford 5A or 6A, respectively. On the other hand, an another diastereoisomer, (R*s,9R*)-3B, was not solvated by EtOH or H2O under the same conditions. The thus obtained solvates (5A, 6A) are much more stable than that of 3A. The antiulcer activities of 5A and 6A were found to be similar to that of the parent compound (3A). Consequently, 6A was selected as an antiulcer agent for the development.

  6. 8 CFR 328.4 - Application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Application. 328.4 Section 328.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS SPECIAL CLASSES OF PERSONS WHO MAY BE NATURALIZED: PERSONS WITH THREE YEARS SERVICE IN ARMED FORCES OF THE UNITED STATES § 328.4 Application....

  7. 8 CFR 315.4 - Exemption treaties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Exemption treaties. 315.4 Section 315.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS PERSONS INELIGIBLE TO CITIZENSHIP: EXEMPTION FROM MILITARY SERVICE § 315.4 Exemption treaties. (a) The following countries...

  8. 8 CFR 315.4 - Exemption treaties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Exemption treaties. 315.4 Section 315.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS PERSONS INELIGIBLE TO CITIZENSHIP: EXEMPTION FROM MILITARY SERVICE § 315.4 Exemption treaties. (a) The following countries...

  9. 8 CFR 315.4 - Exemption treaties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Exemption treaties. 315.4 Section 315.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS PERSONS INELIGIBLE TO CITIZENSHIP: EXEMPTION FROM MILITARY SERVICE § 315.4 Exemption treaties. (a) The following countries...

  10. 8 CFR 315.4 - Exemption treaties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Exemption treaties. 315.4 Section 315.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS PERSONS INELIGIBLE TO CITIZENSHIP: EXEMPTION FROM MILITARY SERVICE § 315.4 Exemption treaties. (a) The following countries...

  11. 8 CFR 315.4 - Exemption treaties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Exemption treaties. 315.4 Section 315.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS PERSONS INELIGIBLE TO CITIZENSHIP: EXEMPTION FROM MILITARY SERVICE § 315.4 Exemption treaties. (a) The following countries...

  12. 8 CFR 322.4 - Interview.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Interview. 322.4 Section 322.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS CHILD BORN OUTSIDE THE UNITED STATES; REQUIREMENTS FOR APPLICATION FOR CERTIFICATE OF CITIZENSHIP § 322.4 Interview. The U.S. citizen parent and...

  13. 8 CFR 264.4 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false 264.4 Section 264.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS REGISTRATION AND FINGERPRINTING OF ALIENS IN THE UNITED STATES § 264.4...

  14. 8 CFR 264.4 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false 264.4 Section 264.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS REGISTRATION AND FINGERPRINTING OF ALIENS IN THE UNITED STATES § 264.4...

  15. 8 CFR 264.4 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false 264.4 Section 264.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS REGISTRATION AND FINGERPRINTING OF ALIENS IN THE UNITED STATES § 264.4...

  16. 8 CFR 264.4 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false 264.4 Section 264.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS REGISTRATION AND FINGERPRINTING OF ALIENS IN THE UNITED STATES § 264.4...

  17. 8 CFR 264.4 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false 264.4 Section 264.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS REGISTRATION AND FINGERPRINTING OF ALIENS IN THE UNITED STATES § 264.4...

  18. 8 CFR 292.4 - Appearances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Appearances. 292.4 Section 292.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS REPRESENTATION AND APPEARANCES § 292.4 Appearances. (a) An appearance shall be filed on the appropriate form by the attorney or...

  19. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An...

  20. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An...

  1. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for...

  2. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An...

  3. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for...

  4. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for...

  5. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for...

  6. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for...

  7. Infrared spectroscopy and Density Functional Theory of crystalline β-2,4,6,8,10,12-hexanitrohexaaziosowurtzitane (β CL-20) in the region of its C-H stretching vibrations

    NASA Astrophysics Data System (ADS)

    Behler, K. D.; Pesce-Rodriguez, R.; Cabalo, J.; Sausa, R.

    2013-10-01

    Molecular vibrational spectroscopy provides a useful tool for material characterization and model verification. We examine the CH stretching fundamental and overtones of energetic material β-2,4,6,8,10,12-hexanitrohexaaziosowurtzitane (β-CL-20) by Raman spectroscopy, Fourier Transform Infrared Spectroscopy, and Laser Photoacoustic Overtone Spectroscopy, and utilize Density Functional Theory to calculate the C-H bond energy of β-CL-20 in a crystal. The spectra reveal four intense and distinct features, whose analysis yields C-H stretching fundamental frequencies and anharmonicity values that range from 3137 to 3170 cm-1 and 53.8 to 58.8 cm-1, respectively. From these data, we estimate an average value of 42,700 cm-1 (5.29 eV) for the C-H bond energy, a value that agrees with our quantum mechanical calculations.

  8. Infrared spectroscopy and Density Functional Theory of crystalline β-2,4,6,8,10,12-hexanitrohexaaziosowurtzitane (β CL-20) in the region of its C-H stretching vibrations.

    PubMed

    Behler, K D; Pesce-Rodriguez, R; Cabalo, J; Sausa, R

    2013-10-01

    Molecular vibrational spectroscopy provides a useful tool for material characterization and model verification. We examine the CH stretching fundamental and overtones of energetic material β-2,4,6,8,10,12-hexanitrohexaaziosowurtzitane (β-CL-20) by Raman spectroscopy, Fourier Transform Infrared Spectroscopy, and Laser Photoacoustic Overtone Spectroscopy, and utilize Density Functional Theory to calculate the C-H bond energy of β-CL-20 in a crystal. The spectra reveal four intense and distinct features, whose analysis yields C-H stretching fundamental frequencies and anharmonicity values that range from 3137 to 3170 cm(-1) and 53.8 to 58.8 cm(-1), respectively. From these data, we estimate an average value of 42,700 cm(-1) (5.29 eV) for the C-H bond energy, a value that agrees with our quantum mechanical calculations. PMID:23832164

  9. Ultrasound Mediated One-Pot, Three Component Synthesis, Docking and ADME Prediction of Novel 5-Amino-2-(4-chlorophenyl)-7-Substituted Phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile Derivatives as Anticancer Agents.

    PubMed

    Tiwari, Shailee V; Seijas, Julio A; Vazquez-Tato, M Pilar; Sarkate, Aniket P; Lokwani, Deepak K; Nikalje, Anna Pratima G

    2016-01-01

    Herein, we report an environmentally friendly, rapid, and convenient one-pot ultrasound-promoted synthesis of 5-amino-2-(4-chlorophenyl)-7-substituted phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile derivatives. The in-vitro anticancer activities of these compounds were evaluated against four human tumor cell lines. Among all the synthesized derivatives, compound 4i, which has substituent 3-hydroxy-4-methoxyphenyl is found to have the highest GI50 value of 32.7 μM, 55.3 μM, 34.3 μM, 28.9 μM for MCF-7, K562, HeLa and PC-3 cancer cell lines respectively. A docking study of the newly synthesized compounds were performed, and the results showed good binding mode in the active site of thymidylate synthase enzyme. ADME properties of synthesized compounds were also studied and showed good drug like properties. PMID:27483213

  10. Crystal structure of (+)-N-[(1R,5S,6S,9S)-5-hydroxy-methyl-3,3,9-trimethyl-8-oxo-2,4,7-trioxabi-cyclo-[4.3.0]nonan-9-yl]acetamide.

    PubMed

    Oishi, Takeshi; Tsuzaki, Shun; Sugai, Tomoya; Sato, Takaaki; Chida, Noritaka

    2016-05-01

    In the title compound, C12H19NO6, the six-membered 1,3-dioxane ring adopts a chair-like conformation. The seat of this chair, containing two O atoms, is essentially planar, with a maximum deviation of 0.0021 (12) Å. The five-membered oxolane ring cis-fused to the 1,3-dioxane ring adopts an envelope form. The bridgehead C atom at the flap, which is bonded to the tetra-substituted C atom of the oxolane ring, deviates from the mean plane of other ring atoms by 0.539 (4) Å. In the crystal, classical O-H⋯O and N-H⋯O hydrogen bonds link the mol-ecules into a sheet structure enclosing an R 4 (4)(24) graph-set motif. Weak inter-molecular C-H⋯O inter-actions support the sheet formation. PMID:27308035

  11. Tunable photoluminescence properties of Ca{sub 8}NaLa(PO{sub 4}){sub 6}F{sub 2}:Eu{sup 2+},Mn{sup 2+} phosphor under UV excitation

    SciTech Connect

    Zhang, Fen; Lan, Tong; Tang, Wanjun

    2015-04-15

    Highlights: • Ca{sub 8}NaLa(PO{sub 4}){sub 6}F{sub 2}:Eu{sup 2+},Mn{sup 2+} was prepared by a combustion-assisted synthesis method. • The phosphor presents blue and yellow double color emissions. • Efficient energy transfer from Eu{sup 2+} to Mn{sup 2+} in this phosphor is observed obviously. • White emitting was realized in Ca{sub 8}NaGd(PO{sub 4}){sub 6}F{sub 2}:0.10Eu{sup 2+},0.32Mn{sup 2+},0.10B phosphor. - Abstract: A series of Eu{sup 2+} and Mn{sup 2+} coactivated Ca{sub 8}NaLa(PO{sub 4}){sub 6}F{sub 2} (CNLF) phosphors have been synthesized by a combustion-assisted synthesis method. The investigation revealed that Ca{sub 8}NaLa(PO{sub 4}){sub 6}F{sub 2} crystallized in a hexagonal crystal system with the space group P6{sub 3}/m (176). The Eu{sup 2+} activated phosphors can be efficiently excited in the range of 270–400 nm and give intense blue emission peaking at 451 nm. By codoping the Eu{sup 2+} and Mn{sup 2+} ions into the CNLF host and singly varying the doping content of the Mn{sup 2+} ion, tunable colors from blue to white and eventually to yellow are obtained in CNLF:Eu{sup 2+},Mn{sup 2+} phosphors under the irradiation of 330 nm. The energy transfer from Eu{sup 2+} to Mn{sup 2+} in CNLF:Eu{sup 2+},Mn{sup 2+} has been demonstrated to be a resonant type via a dipole–dipole mechanism and the critical distance of energy transfer from Eu{sup 2+} to Mn{sup 2+} was estimated to be about 11.9 Å. The investigation indicates that the obtained samples might have potential application in white LEDs.

  12. A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives.

    PubMed

    Lazzari, Paolo; Distinto, Rita; Manca, Ilaria; Baillie, Gemma; Murineddu, Gabriele; Pira, Marilena; Falzoi, Matteo; Sani, Monica; Morales, Paula; Ross, Ruth; Zanda, Matteo; Jagerovic, Nadine; Pinna, Gérard Aimè

    2016-10-01

    8-Chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide 9a was discovered as potent and selective CB1 antagonist by part of our group few years ago. In particular it was reported to have an affinity towards the CB1 cannabinoid receptor (CB1R), expressed as Ki, of 0.00035 nM. Nevertheless significantly divergent data were reported for the same compound from other laboratories. To unequivocally define the receptor profile of 9a, we have critically reviewed both its synthesis approach and binding data. Here we report that, in contrast to our previously reported data, 9a showed a Ki value for CB1R in the order of nanomolar rather than of fentomolar range. The new determined receptor profile of 9a was also ascertained for analogue derivatives 9b-i, as well as for 12. Moreover, the structural features of the synthesized compounds necessary for CB1R were investigated. Amongst the novel series, effects on CB1R intrinsic activity was highlighted due to the substituents at the position 3 of the pyrazole ring of the 1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole scaffold. Although the cannabinoid receptor profile of 9a was reviewed in this work, the relevance of this compound in CB1R antagonist based drug discovery is confirmed.

  13. Computational studies on the crystal structure, thermodynamic properties, detonation performance, and pyrolysis mechanism of 2,4,6,8-tetranitro-1,3,5,7-tetraazacubane as a novel high energy density material.

    PubMed

    Wang, Fang; Du, Hongchen; Zhang, Jianying; Gong, Xuedong

    2011-10-27

    Studies have suggested that octanitrocubane (ONC) is one of the most powerful non-nuclear high energy density material (HEDM) currently known. 2,4,6,8-Tetranitro-1,3,5,7-tetraazacubane (TNTAC) studied in this work may also be a novel HEDM due to its high nitrogen content and crystal density. Density functional theory and molecular mechanics methods have been employed to study the crystal structure, IR spectrum, electronic structure, thermodynamic properties, gas-phase and condensed-phase heat of formation, detonation performance, and pyrolysis mechanism of TNTAC. The TNTAC has a predicted density of about 2.12 g/cm(3), and its detonation velocity (10.42 km/s) and detonation pressure (52.82 GPa) are higher than that of ONC. The crystalline packing is P2(1)2(1)2(1), and the corresponding cell parameters are Z = 4, a = 8.87 Å, b = 8.87 Å, and c = 11.47 Å. Both the density of states of the predicted crystal and the bond dissociation energy of the molecule in gas phase show that the cage C-N bond is the trigger bond during thermolysis. The activation energy of the pyrolysis initiation reaction obtained from the B3LYP/6-311++G(2df,2p) level is 125.98 kJ/mol, which indicates that TNTAC meets the thermal stability request as an exploitable HEDM. PMID:21919441

  14. 6. Photocopy of drawing. (This drawing is an 8' x ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photocopy of drawing. (This drawing is an 8' x 10' enlargement from a 4' x 5' negative; 1942 drawing titled 'Mobilization Buildings, Hospital Mess, Types HM-336-A, B, C, D, E, F, & G, Electrical,' Plan 800-3136, located at Directorate of Engineering and Housing, Fort McPherson.) - Fort McPherson, World War II Station Hospital, Mess Hall, Anderson Way & Howe Street, Atlanta, Fulton County, GA

  15. GTE_TRACEP_DC8 Parameters 6

    Atmospheric Science Data Center

    2013-02-18

    ... (C2HCl3) Carbon tetrachloride (CCl4) Methylene bromide (CH2Br2) Chlorobromomethane (CH2BrCl) Dichloromethane (CH2Cl2) Methylbromide (CH3Br) Chloroform (CH3CCl3) Methyl Chloride (CH3Cl) Methyl Iodide (CH3I) Chlorodibromomethane ...

  16. Effects R3+ on the photoluminescent properties of Ca2R8(SiO4)6O2:A (R = Y,La,Gd;A = Eu3+,Tb3+) phosphor films prepared by the sol gel process

    NASA Astrophysics Data System (ADS)

    Han, X. M.; Lin, J.; Zhou, H. L.; Yu, M.; Zhou, Y. H.; Pang, M. L.

    2004-04-01

    Using CaCO3, metal oxides (all dissolved by nitric acid) and tetraethoxysilane Si(OC2H5)4 (TEOS) as the main starting materials, Ca2R8(SiO4)6O2:A (R = Y,La,Gd;A = Eu3+,Tb3+) phosphor films have been dip-coated on quartz glass substrates through the sol-gel process. X-ray diffraction (XRD), atomic force microscope (AFM), scanning electron microscope (SEM) and photoluminescence (PL) spectra as well as lifetimes were used to characterize the resulting films. The results of XRD indicated that the 1000 °C annealed films are isomorphous and crystallize with the silicate oxyapatite structure. AFM and SEM studies revealed that the phosphor films consisted of homogeneous particles ranging from 30 to 90 nm, with an average thickness of 1.30 µm. The Eu3+ and Tb3+ show similar spectral properties independent of R3+ in the films due to their isomorphous crystal structures. However, both the emission intensity and lifetimes of Eu3+ and Tb3+ in Ca2R8(SiO4)6O2 (R = Y, La, Gd) films decrease in the sequence of R = Gd>R = Y>R = La, which have been explained in accordance with the crystal structures.

  17. Gas-phase reactions of the bare Th2+ and U2+ ions with small alkanes, CH4, C2H6, and C3H8: experimental and theoretical study of elementary organoactinide chemistry.

    PubMed

    Di Santo, Emanuela; Santos, Marta; Michelini, Maria C; Marçalo, Joaquim; Russo, Nino; Gibson, John K

    2011-02-16

    The gas-phase reactions of two dipositive actinide ions, Th(2+) and U(2+), with CH(4), C(2)H(6), and C(3)H(8) were studied by both experiment and theory. Fourier transform ion cyclotron resonance mass spectrometry was employed to study the bimolecular ion-molecule reactions; the potential energy profiles (PEPs) for the reactions, both observed and nonobserved, were computed by density functional theory (DFT). The experiments revealed that Th(2+) reacts with all three alkanes, including CH(4) to produce ThCH(2)(2+), whereas U(2+) reacts with C(2)H(6) and C(3)H(8), with different product distributions than for Th(2+). The comparative reactivities of Th(2+) and U(2+) toward CH(4) are well explained by the computed PEPs. The PEPs for the reactions with C(2)H(6) effectively rationalize the observed reaction products, ThC(2)H(2)(2+) and UC(2)H(4)(2+). For C(3)H(8) several reaction products were experimentally observed; these and additional potential reaction pathways were computed. The DFT results for the reactions with C(3)H(8) are consistent with the observed reactions and the different products observed for Th(2+) and U(2+); however, several exothermic products which emerge from energetically favorable PEPs were not experimentally observed. The comparison between experiment and theory reveals that DFT can effectively exclude unfavorable reaction pathways, due to energetic barriers and/or endothermic products, and can predict energetic differences in similar reaction pathways for different ions. However, and not surprisingly, a simple evaluation of the PEP features is insufficient to reliably exclude energetically favorable pathways. The computed PEPs, which all proceed by insertion, were used to evaluate the relationship between the energetics of the bare Th(2+) and U(2+) ions and the energies for C-H and C-C activation. It was found that the computed energetics for insertion are entirely consistent with the empirical model which relates insertion efficiency to the

  18. Properties and performance of La{sub 1.6}Sr{sub 0.4}NiO{sub 4+{delta}}-Ce{sub 0.8}Sm{sub 0.2}O{sub 1.9} composite cathodes for intermediate temperature solid oxide fuel cells

    SciTech Connect

    Gong Mingguang; Lu Lihua; Zhang Hua; Gao Lirong; Guo Youbin; Jin Jiang

    2009-08-05

    La{sub 1.6}Sr{sub 0.4}NiO{sub 4+{delta}}-Ce{sub 0.8}Sm{sub 0.2}O{sub 1.9} composite cathodes were prepared successfully using combustion synthesis method for intermediate temperature solid oxide fuel cells. The chemical compatibility, thermal expansion behavior, electrical conductivity and electrode performance were studied. The X-ray diffraction of La{sub 1.6}Sr{sub 0.4}NiO{sub 4+{delta}}-Ce{sub 0.8}Sm{sub 0.2}O{sub 1.9} composite result proved a slight reaction between La{sub 1.6}Sr{sub 0.4}NiO{sub 4+{delta}} and Ce{sub 0.8}Sm{sub 0.2}O{sub 1.9}. Both the thermal expansion coefficient and the electrical conductivity of La{sub 1.6}Sr{sub 0.4}NiO{sub 4+{delta}}-Ce{sub 0.8}Sm{sub 0.2}O{sub 1.9} decreased with increasing Ce{sub 0.8}Sm{sub 0.2}O{sub 1.9} content. AC impedance spectroscopy measurements indicated that the addition of 30 wt% Ce{sub 0.8}Sm{sub 0.2}O{sub 1.9} to La{sub 1.6}Sr{sub 0.4}NiO{sub 4+{delta}} exhibited the lowest polarization resistance (0.238 {Omega}cm{sup 2}) at 800 deg. C in air, which was only one fourth of the La{sub 1.6}Sr{sub 0.4}NiO{sub 4+{delta}} electrode measured at the same temperature.

  19. 8 CFR 245.4 - Documentary requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Documentary requirements. 245.4 Section 245... STATUS TO THAT OF PERSON ADMITTED FOR PERMANENT RESIDENCE § 245.4 Documentary requirements. The provisions of part 211 of this chapter relating to the documentary requirements for immigrants shall...

  20. 8 CFR 1245.4 - Documentary requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Documentary requirements. 1245.4 Section 1245.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE... Documentary requirements. The provisions of part 1211 of this chapter relating to the documentary...

  1. 8 CFR 103.4 - Certifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Certifications. 103.4 Section 103.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees §...

  2. 8 CFR 103.4 - Certifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Certifications. 103.4 Section 103.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees §...

  3. 8 CFR 103.4 - Certifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Certifications. 103.4 Section 103.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees §...

  4. 8 CFR 331.4 - Procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Procedures. 331.4 Section 331.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS ALIEN ENEMIES; NATURALIZATION UNDER... naturalization is an alien enemy, the Service shall notify the applicant in writing of its determination....

  5. 8 CFR 331.4 - Procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Procedures. 331.4 Section 331.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS ALIEN ENEMIES; NATURALIZATION UNDER... naturalization is an alien enemy, the Service shall notify the applicant in writing of its determination....

  6. 8 CFR 331.4 - Procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Procedures. 331.4 Section 331.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS ALIEN ENEMIES; NATURALIZATION UNDER... naturalization is an alien enemy, the Service shall notify the applicant in writing of its determination....

  7. 8 CFR 331.4 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Procedures. 331.4 Section 331.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS ALIEN ENEMIES; NATURALIZATION UNDER... naturalization is an alien enemy, the Service shall notify the applicant in writing of its determination....

  8. 8 CFR 331.4 - Procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Procedures. 331.4 Section 331.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS ALIEN ENEMIES; NATURALIZATION UNDER... naturalization is an alien enemy, the Service shall notify the applicant in writing of its determination....

  9. Crystal structure of (1S,3R,8R,9R)-2,2-di-chloro-3,7,7-tri-methyl-10-methylenetri-cyclo-[6.4.0.0(1,3)]dodecan-9-ol.

    PubMed

    Benzalim, Ahmed; Auhmani, Aziz; Bimoussa, Abdoullah; Ait Itto, My Youssef; Daran, Jean-Claude; Auhmani, Abdelwahed

    2016-08-01

    The title compound, C16H24Cl2O, was synthesized by treating (1S,3R,8S,9R,10S)-2,2-di-chloro-3,7,7,10-tetra-methyl-9,10-ep-oxy-tri-cyclo-[6.4.0.0(1,3)]dodecane with a concentrated solution of hydro-bromic acid. It is built up from three fused rings: a cyclo-heptane ring, a cyclo-hexyl ring bearing alkene and hy-droxy substituents, and a cyclo-propane ring bearing two chlorine atoms. The asymmetric unit contains two mol-ecules linked by an O-H⋯O hydrogen bond. In the crystal, further O-H⋯O hydrogen bonds build up an R 4 (4)(8) cyclic tetra-mer. One of the mol-ecules presents disorder that affects the seven-membered ring. In both mol-ecules, the six-membered rings display a chair conformation, whereas the seven-membered rings display conformations inter-mediate between boat and twist-boat for the non-disordered mol-ecule and either a chair or boat and twist-boat for the disordered mol-ecule owing to the disorder. The absolute configuration for both mol-ecules is 1S,3R,8R,9R and was deduced from the chemical pathway and further confirmed by the X-ray structural analysis. PMID:27536404

  10. Heavy perfluorocarbons in the global atmosphere: Atmospheric histories and top-down global emission estimates for C4F10, C5F12, C6F14, C7F16 and C8F18

    NASA Astrophysics Data System (ADS)

    Ivy, D. J.; Arnold, T.; Rigby, M. L.; Baasandorj, M.; Muhle, J.; Harth, C.; Salameh, P.; Steele, P.; Leist, M.; Krummel, P. B.; Burkholder, J. B.; Fraser, P.; Weiss, R. F.; Prinn, R. G.

    2011-12-01

    The high molecular weight perfluorocarbons (PFCs) - perfluorobutane (C4F10), perfluoropentane (C5F12), perfluorohexane (C6F14), perfluoroheptane (C7F16) and perfluorooctane (C8F18) - are potent greenhouse gases with global warming potentials of ~ 9000 for a 100 year time horizon [Forster et al., 2007]. Currently, the heavy PFCs are regulated under the Kyoto Protocol of the United Nations Framework Convention on Climate Change (UNFCCC). However, no atmospheric observations or top-down emission estimates for these gases have been published. In this study, atmospheric histories of the heavy PFCs were determined through new measurements of the Cape Grim Air Archive and a collection of Northern Hemispheric archive flasks using the Advanced Global Atmospheric Gases Experiment (AGAGE) cryogenic preconcentration gas chromatography-mass spectrometry system "Medusa" [Miller et al., 2008]. Furthermore, global top-down emissions were estimated from 1973-2010 based on the atmospheric histories using an inverse method and the 3-D chemical transport model, Model of OZone and Related Tracers (MOZARTv4.5) [Emmons et al., 2009]. Comparison of the top-down emission estimates with bottom-up estimates from the Emissions Database for Global Atmospheric Research (EDGARv4.1) shows EDGARv4.1 emission estimates are underestimated by orders of magnitude for C4F10 and C5F12 [European Commission, 2009]. The bottom-up estimates from EDGARv4.1 are comparable to the top-down estimates for C6F14 and C7F16; no bottom-up emission estimates are available for C8F18. Generally, UNFCCC reported inventories by countries that have ratified the Kyoto Protocol are 5 to 10 times lower than the top-down emission estimates for C4F10, C5F12 and C6F14 (C7F16 and C8F18 are not reported to the UNFCCC). The atmospheric histories and top-down emission estimates presented are the most accurate and comprehensive compiled so far for the high molecular weight PFCs. Furthermore, this study illustrates the importance of

  11. Atmospheric abundance and global emissions of perfluorocarbons CF4, C2F6 and C3F8 since 1800 inferred from ice core, firn, air archive and in situ measurements

    NASA Astrophysics Data System (ADS)

    Trudinger, Cathy M.; Fraser, Paul J.; Etheridge, David M.; Sturges, William T.; Vollmer, Martin K.; Rigby, Matt; Martinerie, Patricia; Mühle, Jens; Worton, David R.; Krummel, Paul B.; Steele, L. Paul; Miller, Benjamin R.; Laube, Johannes; Mani, Francis S.; Rayner, Peter J.; Harth, Christina M.; Witrant, Emmanuel; Blunier, Thomas; Schwander, Jakob; O'Doherty, Simon; Battle, Mark

    2016-09-01

    Perfluorocarbons (PFCs) are very potent and long-lived greenhouse gases in the atmosphere, released predominantly during aluminium production and semiconductor manufacture. They have been targeted for emission controls under the United Nations Framework Convention on Climate Change. Here we present the first continuous records of the atmospheric abundance of CF4 (PFC-14), C2F6 (PFC-116) and C3F8 (PFC-218) from 1800 to 2014. The records are derived from high-precision measurements of PFCs in air extracted from polar firn or ice at six sites (DE08, DE08-2, DSSW20K, EDML, NEEM and South Pole) and air archive tanks and atmospheric air sampled from both hemispheres. We take account of the age characteristics of the firn and ice core air samples and demonstrate excellent consistency between the ice core, firn and atmospheric measurements. We present an inversion for global emissions from 1900 to 2014. We also formulate the inversion to directly infer emission factors for PFC emissions due to aluminium production prior to the 1980s. We show that 19th century atmospheric levels, before significant anthropogenic influence, were stable at 34.1 ± 0.3 ppt for CF4 and below detection limits of 0.002 and 0.01 ppt for C2F6 and C3F8, respectively. We find a significant peak in CF4 and C2F6 emissions around 1940, most likely due to the high demand for aluminium during World War II, for example for construction of aircraft, but these emissions were nevertheless much lower than in recent years. The PFC emission factors for aluminium production in the early 20th century were significantly higher than today but have decreased since then due to improvements and better control of the smelting process. Mitigation efforts have led to decreases in emissions from peaks in 1980 (CF4) or early-to-mid-2000s (C2F6 and C3F8) despite the continued increase in global aluminium production; however, these decreases in emissions appear to have recently halted. We see a temporary reduction of around

  12. 16 CFR 1207.6-1207.8 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false 1207.6-1207.8 Section 1207.6-1207.8 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR SWIMMING POOL SLIDES §§ 1207.6-1207.8...

  13. 16 CFR 1207.6-1207.8 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false 1207.6-1207.8 Section 1207.6-1207.8 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR SWIMMING POOL SLIDES §§ 1207.6-1207.8...

  14. 16 CFR 1207.6-1207.8 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false 1207.6-1207.8 Section 1207.6-1207.8 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR SWIMMING POOL SLIDES §§ 1207.6-1207.8...

  15. 28 CFR 8.6 - Quick-release authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Quick-release authority. 8.6 Section 8.6 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.6 Quick-release authority. Where the forfeiture proceedings are administrative, the Special Agent in Charge,...

  16. 28 CFR 8.6 - Quick-release authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Quick-release authority. 8.6 Section 8.6 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.6 Quick-release authority. Where the forfeiture proceedings are administrative, the Special Agent in Charge,...

  17. 28 CFR 8.6 - Quick-release authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Quick-release authority. 8.6 Section 8.6 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.6 Quick-release authority. Where the forfeiture proceedings are administrative, the Special Agent in Charge,...

  18. 29 CFR 6.8 - Transmission of record.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Transmission of record. 6.8 Section 6.8 Labor Office of the Secretary of Labor RULES OF PRACTICE FOR ADMINISTRATIVE PROCEEDINGS ENFORCING LABOR STANDARDS IN FEDERAL AND FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS General § 6.8 Transmission of...

  19. 29 CFR 6.8 - Transmission of record.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Transmission of record. 6.8 Section 6.8 Labor Office of the Secretary of Labor RULES OF PRACTICE FOR ADMINISTRATIVE PROCEEDINGS ENFORCING LABOR STANDARDS IN FEDERAL AND FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS General § 6.8 Transmission of...

  20. 29 CFR 6.8 - Transmission of record.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Transmission of record. 6.8 Section 6.8 Labor Office of the Secretary of Labor RULES OF PRACTICE FOR ADMINISTRATIVE PROCEEDINGS ENFORCING LABOR STANDARDS IN FEDERAL AND FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS General § 6.8 Transmission of...

  1. 29 CFR 6.8 - Transmission of record.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Transmission of record. 6.8 Section 6.8 Labor Office of the Secretary of Labor RULES OF PRACTICE FOR ADMINISTRATIVE PROCEEDINGS ENFORCING LABOR STANDARDS IN FEDERAL AND FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS General § 6.8 Transmission of...

  2. 29 CFR 6.8 - Transmission of record.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Transmission of record. 6.8 Section 6.8 Labor Office of the Secretary of Labor RULES OF PRACTICE FOR ADMINISTRATIVE PROCEEDINGS ENFORCING LABOR STANDARDS IN FEDERAL AND FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS General § 6.8 Transmission of...

  3. 40 CFR 8.6 - Preliminary environmental review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Preliminary environmental review. 8.6 Section 8.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.6 Preliminary environmental review. (a) Unless...

  4. 40 CFR 8.6 - Preliminary environmental review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Preliminary environmental review. 8.6 Section 8.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.6 Preliminary environmental review. (a) Unless...

  5. 38 CFR 6.8 - Selection, revocation and election.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Selection, revocation and election. 6.8 Section 6.8 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS UNITED STATES GOVERNMENT LIFE INSURANCE Optional Settlement § 6.8 Selection, revocation and election....

  6. 38 CFR 6.8 - Selection, revocation and election.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Selection, revocation and election. 6.8 Section 6.8 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS UNITED STATES GOVERNMENT LIFE INSURANCE Optional Settlement § 6.8 Selection, revocation and election....

  7. 38 CFR 6.8 - Selection, revocation and election.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Selection, revocation and election. 6.8 Section 6.8 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS UNITED STATES GOVERNMENT LIFE INSURANCE Optional Settlement § 6.8 Selection, revocation and election....

  8. 38 CFR 8.6 - Calculation of time period.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Calculation of time period. 8.6 Section 8.6 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Calculation of Time Period § 8.6 Calculation of time period. If the last day of...

  9. 38 CFR 8.6 - Calculation of time period.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Calculation of time period. 8.6 Section 8.6 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Calculation of Time Period § 8.6 Calculation of time period. If the last day of...

  10. 38 CFR 8.6 - Calculation of time period.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Calculation of time period. 8.6 Section 8.6 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Calculation of Time Period § 8.6 Calculation of time period. If the last day of...

  11. 38 CFR 8.6 - Calculation of time period.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Calculation of time period. 8.6 Section 8.6 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Calculation of Time Period § 8.6 Calculation of time period. If the last day of...

  12. 40 CFR 8.6 - Preliminary environmental review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Preliminary environmental review. 8.6 Section 8.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.6 Preliminary environmental review. (a) Unless...

  13. 16 CFR 1207.6-1207.8 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false 1207.6-1207.8 Section 1207.6-1207.8 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR SWIMMING POOL SLIDES §§ 1207.6-1207.8...

  14. 16 CFR 1207.6-1207.8 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false 1207.6-1207.8 Section 1207.6-1207.8 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR SWIMMING POOL SLIDES §§ 1207.6-1207.8...

  15. 2-tert-Butylamino-4-chloro-6-ethylamino-1,3,5-triazine: a structure with Z' = 4 containing two different molecular conformations and two independent chains of hydrogen-bonded R(2)2(8) rings.

    PubMed

    Quesada, Antonio; Fontecha, Maria A; López, Maria V; Low, John N; Glidewell, Christopher

    2008-08-01

    The title compound (trivial name terbutylazine), C(9)H(16)ClN(5), (I), crystallizes with Z' = 4 in the space group Pca2(1), and equal numbers of molecules adopt two different conformations for the ethylamine groups. The four independent molecules form two approximately enantiomorphic pairs. Eight independent N-H...N hydrogen bonds link the molecules into two independent chains of R(2)(2)(8) rings, in which the arrangement of the alkylamine substituents in the independent molecules precludes any further crystallographic symmetry. The significance of this study lies in its finding of two distinct molecular conformations within the structure and two distinct ways in which the molecules are organized into hydrogen-bonded chains, and in its comparison of the hydrogen-bonded structure of (I) with those of analogous 1,3,5-triazines and pyrimidines. PMID:18682660

  16. Chemical compatibility of (La{sub 0.6}Ca{sub 0.4}){sub x}Fe{sub 0.8}M{sub 0.2}O{sub 3} with yttria-stabilized zirconia

    SciTech Connect

    Kindermann, L.; Das, D.; Nickel, H.; Hilpert, K.; Appel, C.C.; Poulson, F.W.

    1997-02-01

    LaFeO{sub 3}-based perovskites are of interest as cathode material for the development of advanced solid oxide fuel cells operating at temperatures significantly lower than 900 C. The compatibility of the selected materials is necessary to guarantee long-term operation of a solid oxide fuel cell. Systematic investigations on the reactivity between the solid electrolyte yttria-stabilized zirconia (ZrO{sub 2} + 8 mole percent Y{sub 2}O{sub 3}) and the perovskites (La{sub 0.6}Ca{sub 0.4}){sub x}Fe{sub 0.8}M{sub 0.2}O{sub 3} (x = 1, 0.9; M = Cr, Mn, Co, Ni) were carried out. The results obtained are discussed.

  17. Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1.

    PubMed

    Garcia-Bates, Tatiana M; Kim, Eun; Concha-Benavente, Fernando; Trivedi, Sumita; Mailliard, Robbie B; Gambotto, Andrea; Ferris, Robert L

    2016-03-15

    The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma has increased in recent decades, though HPV prevention vaccines may reduce this rise in the future. HPV-related cancers express the viral oncoproteins E6 and E7. The latter inactivates the tumor suppressor protein retinoblastoma (Rb), which leads to the overexpression of p16(INK4) protein, providing unique Ags for therapeutic HPV-specific cancer vaccination. We developed potential adenoviral vaccines that express a fusion protein of HPV-16 E6 and E7 (Ad.E6E7) alone or fused with p16 (Ad.E6E7p16) and also encoding an anti-programmed death (PD)-1 Ab. Human monocyte-derived dendritic cells (DC) transduced with Ad.E6E7 or Ad.E6E7p16 with or without Ad.αPD1 were used to activate autologous CD8 CTL in vitro. CTL responses were tested against naturally HPV-infected head and neck squamous cell carcinoma cells using IFN-γ ELISPOT and [(51)Cr]release assay. Surprisingly, stimulation and antitumor activity of CTL were increased after incubation with Ad.E6E7p16-transduced DC (DC.E6E7p16) compared with Ad.E6E7 (DC.E6E7), a result that may be due to an effect of p16 on cyclin-dependent kinase 4 levels and IL-12 secretion by DC. Moreover, the beneficial effect was most prominent when anti-PD-1 was introduced during the second round of stimulation (after initial priming). These data suggest that careful sequencing of Ad.E6E7.p16 with Ad.αPD1 could improve antitumor immunity against HPV-related tumors and that p16 may enhance the immunogenicity of DC, through cyclin-dependent pathways, Th1 cytokine secretion, and by adding a nonviral Ag highly overexpressed in HPV-induced cancers. PMID:26851223

  18. The Marine-Derived Fungus Clonostachys rosea, Source of a Rare Conjugated 4-Me-6E,8E-hexadecadienoic Acid Reducing Viability of MCF-7 Breast Cancer Cells and Gene Expression of Lipogenic Enzymes

    PubMed Central

    Dos Santos Dias, Ana Camila; Ruiz, Nicolas; Couzinet-Mossion, Aurélie; Bertrand, Samuel; Duflos, Muriel; Pouchus, Yves-François; Barnathan, Gilles; Nazih, Hassan; Wielgosz-Collin, Gaetane

    2015-01-01

    A marine-derived strain of Clonostachys rosea isolated from sediments of the river Loire estuary (France) was investigated for its high lipid production. The fungal strain was grown on six different culture media to explore lipid production changes. An original branched conjugated fatty acid, mainly present in triglycerides and mostly produced when grown on DCA (23% of total fatty acid composition). It was identified as 4-Me-6E,8E-hexadecadienoic on the basis of spectroscopic analyses. This fatty acid reduced viability of MCF-7 breast cancer cells in a dose dependent manner (up to 63%) at physiological free fatty acid human plasma concentration (100 μM). Reduction of gene expression of two lipogenic enzymes, the acetyl CoA carboxylase (ACC) and the fatty acid synthase (FAS) was evaluated to explore the mechanisms of action of 4-Me-6E,8E-16:2 acid. At 50 μM, 50% and 35% of mRNA gene expression inhibition were observed for ACC and FAS, respectively. PMID:26258780

  19. The Marine-Derived Fungus Clonostachys rosea, Source of a Rare Conjugated 4-Me-6E,8E-hexadecadienoic Acid Reducing Viability of MCF-7 Breast Cancer Cells and Gene Expression of Lipogenic Enzymes.

    PubMed

    Dias, Ana Camila Dos Santos; Ruiz, Nicolas; Couzinet-Mossion, Aurélie; Bertrand, Samuel; Duflos, Muriel; Pouchus, Yves-François; Barnathan, Gilles; Nazih, Hassan; Wielgosz-Collin, Gaetane

    2015-08-01

    A marine-derived strain of Clonostachys rosea isolated from sediments of the river Loire estuary (France) was investigated for its high lipid production. The fungal strain was grown on six different culture media to explore lipid production changes. An original branched conjugated fatty acid, mainly present in triglycerides and mostly produced when grown on DCA (23% of total fatty acid composition). It was identified as 4-Me-6E,8E-hexadecadienoic on the basis of spectroscopic analyses. This fatty acid reduced viability of MCF-7 breast cancer cells in a dose dependent manner (up to 63%) at physiological free fatty acid human plasma concentration (100 μM). Reduction of gene expression of two lipogenic enzymes, the acetyl CoA carboxylase (ACC) and the fatty acid synthase (FAS) was evaluated to explore the mechanisms of action of 4-Me-6E,8E-16:2 acid. At 50 μM, 50% and 35% of mRNA gene expression inhibition were observed for ACC and FAS, respectively. PMID:26258780

  20. Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.

    PubMed

    Oztürk Yildirim, Sema; Butcher, Ray J; Gündüz, Miyase Gözde; El-Khouly, Ahmed; Simşek, Rahime; Safak, Cihat

    2013-01-01

    In the title mol-ecule, C24H28N2O3, the cyclo-hexene ring is in a sofa conformation and the 1,4-dihydro-pyridine ring is in a slight boat conformation. In the indole ring system, the pyrrole and benzene rings form a dihedral angle of 2.63 (7)°. In the crystal, N-H⋯O hydrogen bonds connect the mol-ecules into C(6) chains parallel to the b axis and pairs of weak C-H⋯O hydrogen bonds link inversion-related chains into a ladder motif through R2(2)(18) rings. A weak intra-molecular C-H⋯O hydrogen bond is also observed. PMID:23476426

  1. Fragrance material review on 6,8-dimethylnonan-2-ol.

    PubMed

    McGinty, D; Scognamiglio, J; Letizia, C S; Api, A M

    2010-07-01

    A toxicologic and dermatologic review of 6,8-dimethylnonan-2-ol when used as a fragrance ingredient is presented. 6,8-Dimethylnonan-2-ol is a member of the fragrance structural group branched chain saturated alcohols. The common characteristic structural elements of the alcohols with saturated branched chain are one hydroxyl group per molecule, and a C(4)-C(12) carbon chain with one or several methyl side chains. This review contains the information available on this individual fragrance ingredient and is not intended as a stand-alone document. A safety assessment of the entire branched chain saturated alcohol group will be published simultaneously with this document; please refer to Belsito et al. (2010) for an overall assessment of the safe use of this material and all other branched chain saturated alcohols in fragrances.

  2. Crystal structure and computational study of 3,4-dihy­droxy-3-hy­droxy­methyl-9-methyl-6-methyl­idene-3a,4,5,6,6a,9,9a,9b-octa­hydro­azuleno[4,5-b]furan-2,8(3H,7H)-dione

    PubMed Central

    Çelik, Ísmail; Akkurt, Mehmet; Akşit, Hüseyin; Erenler, Ramazan; García-Granda, Santiago

    2015-01-01

    In the mol­ecule of title compound, C15H20O6, also known as cynarinin A, the cyclo­pentane ring having twist conformation and a γ-lactone ring assuming an envelope conformation are trans- and cis-fused, respectively, to a cyclo­heptane ring adopting a twist-chair conformation. In the crystal, O—H⋯O hydrogen bonds link neighbouring mol­ecules, forming a three-dimensional network. Theoretical calculations of the mol­ecular structure using the CNDO approximation and MOPAC PM3 geometry optimization are in satisfactory agreement with the results of the X-ray structure analysis. PMID:26870396

  3. Face-driven corner-linked octahedral nanocages: M6L8 cages formed by C3-symmetric triangular facial ligands linked via C4-symmetric square tetratopic Pd(II) ions at truncated octahedron corners.

    PubMed

    Moon, Dohyun; Kang, Sangmi; Park, Jaejoon; Lee, Kyungjae; John, Rohith P; Won, Hosik; Seong, Gi Hun; Kim, Yang Sun; Kim, Ghyung Hwa; Rhee, Hakjune; Lah, Myoung Soo

    2006-03-22

    The face-driven corner-linked truncated octahedral nanocages, [Pd6L8]12+ (1, L1 = N,N',N' '-tris(3-pyridinyl)-1,3,5-benzenetricarboxamide; 2, L2 = N,N',N' '-tris(4-pyridinylmethyl)-1,3,5-benzenetricarboxamide), were prepared with eight C3-symmetric tridentate ligands and six square planar tetratopic palladium(II) ions. The combination of the nitrogen donor atom at a approximately 120 degrees kink position of the carboxamido pyridinyl group and the tilted pyridyl versus the facial plane of the ligands can provide the needed curvature for the formation of octahedral cages. The nitrogen atoms can coordinate to the square planar palladium(II) ions to form kinks with approximately 120 degrees angles at the C4-symmetric square planar corners of the truncated octahedron. Depending on the conformation of the ligand, L1, two different truncated octahedral cages of around 2.4 nm in diameters were formed. The major form of 1 with syn-conformational ligands has a cavity volume of approximately 1600 A3. The cage has 12 ports (3.4 x 3.5 A2) at all edges of the octahedron. The minor form of cage 1 with anti-conformational ligands has a slightly increased cavity volume ( approximately 1900 A3) and port size (3.3 x 8.0 A2). The insertion of a methylene group in L2 has not only increased the cavity volume of 2 to approximately 2200 A3 but also enlarged the port size to 4.1 x 8.0 A2. However, an atomic force microscopy (AFM) study of cage 2 showed that the cages had a height of 1.8 +/- 0.1 nm. This value is about 30% smaller than the calculated size of 2.6 nm from the crystal structure. This tip-induced decrease in height in cage 2 suggests the nonrigidity of cage 2. PMID:16536521

  4. Synthesis, crystal structure and photoluminescence of a new Eu-doped Sr containing sialon (Sr0.94Eu0.06)(Al0.3Si0.7)4(N0.8O0.2)6

    NASA Astrophysics Data System (ADS)

    Yamane, Hisanori; Shimooka, Satoshi; Uheda, Kyota

    2012-06-01

    Colorless transparent platelet single crystals of a novel Eu2+-doped strontium silicon aluminum oxynitride, (Sr0.94Eu0.06)(Al0.3Si0.7)4(N0.8O0.2)6, were prepared at 1800 °C and 0.92 MPa of N2. Fundamental reflections of electron and X-ray diffraction of the crystals were indexed with a face-centered orthorhombic unit cell (a=5.8061(5) Å, b=37.762(3) Å, c=9.5936(9) Å). Diffuse streaks elongated in the b-axis direction were observed around the fundamental reflections hkl with h=2n+1 of the electron and X-ray diffraction, indicating stacking faults of (0 1 0)[1 0 0]/2. A crystal structure model without the stacking faults was obtained using the X-ray diffraction data of the fundamental reflections with the space group Fdd2. A SiN4-tetrahedron double layer of [SiN2]2 and a Sr/Eu double layer of [(Sr0.94Eu0.06)Al1.2Si0.8N0.8 O1.2]2 are stacked alternately along the b-axis direction. The title compound showed an emission with a peak wavelength of 490 nm under 334 nm excitation at room temperature.

  5. Synthesis and catalysis of di- and tetranuclear metal sandwich-type silicotungstates [(gamma-SiW10O36)2M2(mu-OH)2]10- and [(gamma-SiW10O36)2M4(mu4-O)(mu-OH)6]8- (M = Zr or Hf).

    PubMed

    Kikukawa, Yuji; Yamaguchi, Syuhei; Tsuchida, Kazutaka; Nakagawa, Yoshinao; Uehara, Kazuhiro; Yamaguchi, Kazuya; Mizuno, Noritaka

    2008-04-23

    The di- and tetranuclear metal sandwich-type silicotungstates of Cs10[(gamma-SiW10O36)2{Zr(H2O)}2(mu-OH)2] x 18 H2O (Zr2, monoclinic, C2/c (No. 15), a = 25.3315(8) A, b = 22.6699(7) A, c = 18.5533(6) A, beta = 123.9000(12) degrees, V = 8843.3(5) A(3), Z = 4), Cs10[(gamma-SiW10O36)2{Hf(H2O)}2(mu-OH)2] x 17 H2O (Hf2, monoclinic, space group C2/c (No. 15), a = 25.3847(16) A, b = 22.6121(14) A, c = 18.8703(11) A, beta = 124.046(3) degrees, V = 8974.9(9) A(3), Z = 4), Cs8[(gamma-SiW10O36)2{Zr(H2O)}4(mu4-O)(mu-OH)6] x 26 H2O (Zr4, tetragonal, P4(1)2(1)2 (No. 92), a = 12.67370(10) A, c = 61.6213(8) A, V = 9897.78(17) A(3), Z = 4), and Cs8[(gamma-SiW10O36)2{Hf(H2O)}4(mu4-O)(mu-OH)6] x 23 H2O (Hf4, tetragonal, P4(1)2(1)2 (No. 92), a = 12.68130(10) A, c = 61.5483(9) A, V = 9897.91(18) A(3), Z = 4) were obtained as single crystals suitable for X-ray crystallographic analyses by the reaction of a dilacunary gamma-Keggin silicotungstate K8[gamma-SiW10O36] with ZrOCl2 x 8 H2O or HfOCl2 x 8 H2O. These dimeric polyoxometalates consisted of two [gamma-SiW10O36](8-) units sandwiching metal-oxygen clusters such as [M2(mu-OH)2](6+) and [M4(mu4-O)(mu-OH)6](8+) (M = Zr or Hf). The dinuclear zirconium and hafnium complexes Zr2 and Hf2 were isostructural. The equatorially placed two metal atoms in Zr2 and Hf2 were linked by two mu-OH ligands and each metal was bound to four oxygen atoms of two [gamma-SiW10O36](8-) units. The tertanuclear zirconium and hafnium complexes Zr4 and Hf4 were isostructural and consisted of the adamantanoid cages with a tetracoordinated oxygen atom in the middle, [M4(mu4-O)(mu-OH)6](8+) (M = Zr or Hf). Each metal atom in Zr4 and Hf4 was linked by three mu-OH ligands and bound to two oxygen atoms of the [gamma-SiW10O36](8-) unit. The tetra-nuclear zirconium and hafnium complexes showed catalytic activity for the intramolecular cyclization of (+)-citronellal to isopulegols without formation of byproducts resulting from etherification and dehydration. A lacunary

  6. Efficient Catalyst One-Pot Synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione Derivatives Complemented by Antibacterial Activity

    PubMed Central

    Al-Majedy, Yasameen K.; Kadhum, Abdul Amir H.; Mohamad, Abu Bakar

    2016-01-01

    The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-(aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide (TBAB), diammonium hydrogen phosphate (DAHP), or ferric chloride (FeCl3), respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity. PMID:27563671

  7. Photochemistry of tricyclo[5.2.2.0(2,6)]undeca-4,10-dien-8-ones: an efficient general route to substituted linear triquinanes from 2-methoxyphenols. Total synthesis of (+/-)-Delta(9(12))-capnellene.

    PubMed

    Hsu, Day-Shin; Chou, Yu-Yu; Tung, Yen-Shih; Liao, Chun-Chen

    2010-03-01

    An efficient and short entry to polyfunctionalized linear triquinanes from 2-methoxyphenols is described by utilizing the following chemistry. The Diels-Alder reactions of masked o-benzoquinones, derived from 2-methoxyphenols, with cyclopentadiene afford tricyclo[5.2.2.0(2,6)]undeca-4,10-dien-8-ones. Photochemical oxa-di-pi-methane (ODPM) rearrangements and 1,3-acyl shifts of the Diels-Alder adducts are investigated. The ODPM-rearranged products are further converted to linear triquinanes by using an O-stannyl ketyl fragmentation. Application of this efficient strategy to the total synthesis of (+/-)-Delta(9(12))-capnellene was accomplished from 2-methoxy-4-methylphenol in nine steps with 20 % overall yield.

  8. Efficient Catalyst One-Pot Synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione Derivatives Complemented by Antibacterial Activity.

    PubMed

    Al-Majedy, Yasameen K; Al-Amiery, Ahmed A; Kadhum, Abdul Amir H; Mohamad, Abu Bakar

    2016-01-01

    The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-(aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide (TBAB), diammonium hydrogen phosphate (DAHP), or ferric chloride (FeCl3), respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity. PMID:27563671

  9. Trefoil factor 3 isolated from human breast milk downregulates cytokines (IL8 and IL6) and promotes human beta defensin (hBD2 and hBD4) expression in intestinal epithelial cells HT-29.

    PubMed

    Barrera, Girolamo Jose; Sanchez, Gabriela; Gonzalez, Jose Emanuele

    2012-11-01

    Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance of the surface integrity of oral mucosa and enhance healing of the gastrointestinal mucosa by a process called restitution. TFF comprises the gastric peptides (TFF1), spasmolytic peptide (TFF2), and the intestinal trefoil factor (TFF3). They have an important and necessary role in epithelial restitution within the gastrointestinal tract. Significant amounts of TFF are present in human milk. This study aimed to determine a possible correlation between TFF3 isolated from human breast milk and levels of cytokines (IL8 and IL6) and defensins (hBD2 and hBD4) in intestinal epithelial cells HT-29 treated with trefoil. Samples of human milk were collected within 2-4 weeks postpartum from healthy human mothers (18-30-years-old) by manual breast massage, and TFF3 was purified by ammonium sulfate precipitation, isoelectric precipitation, DEAE-chromatography, and gel filtration. In this work we measured the concentrations and mRNA levels of cytokines and defensins by immunoassay (ELISA) and semiquantitative RT-PCR technique, respectively. Also we measured the peroxidase activity. We present the first evidence of human milk TFF3 purification. Here we show that the presence of TFF3 isolated from milk strongly correlates with downregulation of IL8 and IL6 in human intestinal epithelial cells. On the other hand, TFF3 activated the epithelial cells in culture to produce beta defensins 2 (hBD2) and beta defensins 4 (hBD4). These findings suggest that TFF can activate intestinal epithelial cells and could actively participate in the immune system of breastfed babies by inducing the production of peptides related to innate defence, such as defensins.

  10. Whole genomic analysis of human G12P[6] and G12P[8] rotavirus strains that have emerged in Kenya: identification of porcine-like NSP4 genes.

    PubMed

    Komoto, Satoshi; Wandera Apondi, Ernest; Shah, Mohammad; Odoyo, Erick; Nyangao, James; Tomita, Mayuko; Wakuda, Mitsutaka; Maeno, Yoshimasa; Shirato, Haruko; Tsuji, Takao; Ichinose, Yoshio; Taniguchi, Koki

    2014-10-01

    G12 rotaviruses are globally emerging rotavirus strains causing severe childhood diarrhea. However, the whole genomes of only a few G12 strains have been fully sequenced and analyzed, of which only one G12P[4] and one G12P[6] are from Africa. In this study, we sequenced and characterized the complete genomes of three G12 strains (RVA/Human-tc/KEN/KDH633/2010/G12P[6], RVA/Human-tc/KEN/KDH651/2010/G12P[8], and RVA/Human-tc/KEN/KDH684/2010/G12P[6]) identified in three stool specimens from children with acute diarrhea in Kenya, Africa. On whole genomic analysis, all three Kenyan G12 strains were found to have a Wa-like genetic backbone: G12-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1 (strains KDH633 and KDH684) and G12-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1 (strain KDH651). Phylogenetic analysis showed that most genes of the three strains examined in this study were genetically related to globally circulating human G1, G9, and G12 strains. Of note is that the NSP4 genes of strains KDH633 and KDH684 appeared to be of porcine origin, suggesting the occurrence of reassortment between human and porcine strains. Furthermore, strains KDH633 and KDH684 were very closely related to each other in all the 11 gene segments, indicating derivation of the two strains from a common origin. On the other hand, strain KDH651 consistently formed distinct clusters of 10 of the 11 gene segments (VP1-2, VP4, VP6-7, and NSP1-5), indicating a distinct origin of strain KDH651 from that of strains KDH633 and KDH684. To our knowledge, this is the first report on whole genome-based characterization of G12 strains that have emerged in Kenya. Our observations will provide important insights into the evolutionary dynamics of emerging G12 rotaviruses in Africa. PMID:25111611

  11. Lhx6 and Lhx8: cell fate regulators and beyond

    PubMed Central

    Zhou, Chen; Yang, Guodong; Chen, Mo; He, Ling; Xiang, Lusai; Ricupero, Christopher; Mao, Jeremy J.; Ling, Junqi

    2015-01-01

    As transcription factors of the lines (LIN)-11/Islet (Isl)-1/mitosis entry checkpoint (MEC)-3 (LIM)-homeobox subfamily, LIM homeobox (Lhx)6 and -8 are remarkably conserved and involved in the morphogenesis of multiple organ systems. Lhx6 and -8 play overlapping and distinctive roles, but in general act as cell fate mediators and in turn are regulated by several transcriptional factors, such as sonic hedgehog, fibroblast growth factors, and wingless-int (Wnt)/β-catenin. In this review, we first summarize Lhx6 and -8 distributions in development and then explore how Lhx6 and -8 act as transcription factors and coregulators of cell lineage specification. Known Lhx6 and -8 functions and targets are outlined in neurogenesis, craniofacial development, and germ cell differentiation. The underlying mechanisms of Lhx6 and -8 in regulating cell fate remain elusive. Whether Lhx6 and -8 affect functions in tissues and organs other than neural, craniofacial, oocytes, and germ cells is largely unexplored. Taken together, Lhx6 and -8 are important regulators of cell lineage specification and may act as one of the pivotal mediators of stem cell fate. Undoubtedly, future investigations of Lhx6 and -8 biology will continue to yield fascinating insights into tissue development and homeostasis, in addition to their putative roles in tissue regeneration and ageing.—Zhou, C., Yang, G., Chen, M., He, L., Xiang, L., Ricupero, C., Mao, J. J., Ling, J. Lhx6 and Lhx8: cell fate regulators and beyond. PMID:26148970

  12. Performances of YBaCo1.4Cu0.6O5+δ–Ce0.8Sm0.2O1.9 composite cathodes for intermediate-temperature solid oxide fuel cells

    DOE PAGES

    Wang, Lizhong; Peng, Lu; Hu, Michael Z.; Lü, Shiquan; Meng, Xiangwei; Yu, Bo; Wei, Maobin; Fan, Hougang; Yang, Lili

    2015-08-20

    In this paper, the electrochemical properties of YBaCo1.4Cu0.6O5+δ–xCe0.8Sm0.2O1.9 (YBCC–xSDC, x=20, 30, 40, 50 wt%) have been investigated for the potential application in intermediate-temperature solid oxide fuel cells (IT-SOFCs). No chemical reactions between YBCC cathode and SDC electrolyte, and YBCC and La0.9Sr0.1Ga0.8Mg0.2O3-δ (LSGM) occur. The thermal expansion coefficient (TEC) of YBCC cathode decreases with SDC addition. The TEC of YBCC–30SDC cathode is 13.60×10–6 K-1 from 30 to 850 °C in air and it exhibits the best electrochemical performance among the YBCC–xSDC cathodes. The polarization resistance (Rp) of YBCC–30SDC is 0.027 Ω cm2 at 850 °C, 0.044 Ω cm2 at 800 °Cmore » and 0.075 Ω cm2 at 750 °C. The maximum power density value of electrolyte-based cell with YBCC–30SDC cathode is 662, 483 and 319 mW cm-2 at 850, 800 and 750 °C, respectively. Finally, preliminary results indicate that YBCC–30SDC is especially promising as a cathode for IT-SOFCs.« less

  13. Thermodynamic data of Ba{sub 0.6}Sr{sub 0.4}Co{sub 0.8}Fe{sub 0.2}O{sub 3−δ} SOFC cathode material

    SciTech Connect

    Botea-Petcu, A.; Tanasescu, S.; Varazashvili, V.; Lejava, N.; Machaladze, T.; Khundadze, M.; Maxim, F.; Teodorescu, F.; Martynczuk, J.; Yáng, Z.; Gauckler, L.J.

    2014-09-15

    Graphical abstract: Partial molar energy of oxygen dissolution (ΔG{sup −}{sub O{sub 2}}) and equilibrium partial pressure of oxygen (log⁡p{sub O{sub 2}}) of perovskite material with the composition Ba{sub 0.6}Sr{sub 0.4}Co{sub 0.8}Fe{sub 0.2}O{sub 3−δ} as a function of temperature. - Highlights: • We report relevant data for thermodynamic stability of Ba{sub 0.6}Sr{sub 0.4}Co{sub 0.8}Fe{sub 0.2}O{sub 3−δ} perovskite compound. • Temperature of structural transformations related to the charge compensation of the material system is evidenced. • The results are discussed based on the properties-defect structure relationship. - Abstract: The compound Ba{sub 0.6}Sr{sub 0.4}Co{sub 0.8}Fe{sub 0.2}O{sub 3−δ} with perovskite structure has been studied focusing mainly on the thermodynamic stability in correlation to the change in the oxygen stoichiometry. The thermochemical behavior has been investigated from room temperature to 1300 K by thermal gravimetry and differential thermal analysis in air and by calorimetry in scanning mode in Argon. The temperature dependence of enthalpy (ΔH{sup T}{sub 298}) in the temperature range of 300–900 K was measured by drop calorimetry. Thermodynamic properties represented by the relative partial molar free energies, enthalpies and entropies of oxygen dissolution in the perovskite phase, as well as the equilibrium partial pressures of oxygen have been obtained in the temperature range of 823–1273 K using solid electrolyte electrochemical cells (EMF). The influence of the oxygen stoichiometry on the thermodynamic properties was examined using a coulometric titration technique coupled with EMF measurements. The results are discussed based on the strong correlation between the energetic parameters and the charge compensation of the material system.

  14. National Ignition Facility subsystem design requirements target area auxiliary subsystem SSDR 1.8.6

    SciTech Connect

    Reitz, T.

    1996-10-20

    This Subsystem Design Requirement (SSDR) establishes the performance, design, development, and test requirements for the Target Area Auxiliary Subsystems (WBS 1.8.6), which is part of the NIF Target Experimental System (WBS 1.8). This document responds directly to the requirements detailed in NIF Target Experimental System SDR 003 document. Key elements of the Target Area Auxiliary Subsystems include: WBS 1.8.6.1 Local Utility Services; WBS 1.8.6.2 Cable Trays; WBS 1.8.6.3 Personnel, Safety, and Occupational Access; WBS 1.8.6.4 Assembly, Installation, and Maintenance Equipment; WBS 1.8.6.4.1 Target Chamber Service System; WBS 1.8.6.4.2 Target Bay Service Systems.

  15. 6. Photocopy of drawing. (This drawing is an 8' x ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photocopy of drawing. (This drawing is an 8' x 10' enlargement from a 4' x 5' negative; 1942 drawing titled 'Mess Halls; Types M-B-T, M-C-T, M-D-T, M-E-T, M-G-T, M-H-T, M-I-T, M-K-T, M-L-T, M-M-T & M-N-T; Electrical,' Plan No. T.O. 700-6601, located at Directorate of Engineering and Housing, Fort McPherson.) - Fort McPherson, World War II Station Hospital, G. U. Treatment Unit Mess Hall, Thorne & Hood Avenues, Atlanta, Fulton County, GA

  16. 3-(2,3,5,6,7,8-Hexahydro-1H-cyclo­penta­[b]quinolin-9-yl)-1,5-bis­(4-methoxy­phen­yl)biuret

    PubMed Central

    Sakurai, Kaori; Noguchi, Keiichi; Nishibe, Koichiro

    2010-01-01

    Ipidacrine (2,3,5,6,7,8-hexa­hydro-1H-cyclo­penta­[b]quinolin-9-amine) was reacted with 4-methoxy­phenyl isocyanate to give the title compound, C28H30N4O4. An intra­molecular N—H⋯O hydrogen bond results in an essentially planar [r.m.s. deviation from the mean plane is 0.126 (1) Å] conformation for the biuret unit. The central ring of the quinoline unit is twisted by 78.2 (1)° with respect to the biuret mean plane, whereas the two 4-methoxy­benzene rings are twisted out of this plane by 24.3 (1)° and 48.5 (1)°, resulting in an overall propeller-like structure. An inter­molecular N—H⋯N hydrogen bond between the biuret NH atom and the quinoline ring nitro­gen defines the crystal packing. PMID:21580406

  17. Long-Term Corrosion Testing of Thermal Spray Coatings of Amorphous Metals: Fe49.7Cr17.7Mn1.9Mo7.4W1.6B15.2C3.8Si2.4 and Fe48Mo14Cr15Y2C15B6

    SciTech Connect

    Farmer, J; Day, D; Lian, T; Saw, C; Hailey, P; Payer, J; Aprigliano, L; Beardsley, B; Branagan, D

    2007-07-09

    Amorphous alloys identified as SAM2X5 (Fe{sub 49.7}Cr{sub 17.7}Mn{sub 1.9}Mo{sub 7.4}W{sub 1.6}B{sub 15.2}C{sub 3.8}Si{sub 2.4}) and SAM1651 (Fe{sub 48}Mo{sub 14}Cr{sub 15}Y{sub 2}C{sub 15}B{sub 6}) have been produced as melt-spun ribbons, drop-cast ingots and thermal-spray coatings. Chromium (Cr), molybdenum (Mo) and tungsten (W) additions provided corrosion resistance, while boron (B) enabled glass formation. Earlier electrochemical studies of melt-spun ribbons and ingots of these amorphous alloys demonstrated outstanding passive film stability. More recently thermal-spray coatings of these amorphous alloys have been made and subjected to long-term salt-fog and immersion tests. Good corrosion resistance has been observed during salt-fog testing. Corrosion rates were measured in situ with linear polarization, while simultaneously monitoring the open-circuit corrosion potentials. Reasonably good performance was observed. The sensitivity of these measurements to electrolyte composition and temperature was determined. The high boron content of SAM2X5 also made it an effective neutron absorber, and suitable for criticality control applications.

  18. Magnetic properties of Ni40+xMn39-xSn21 (x = 0, 2, 4, 6 and 8 at.%) Heusler alloys

    SciTech Connect

    Lázpita, P.; Barandiarán, J. M.; Chernenko, V. A.; Valle García, B.; Díaz Tajada, E.; Lograsso, T.; Schlagel, D. L.

    2014-05-01

    The low electron concentration region (e/a < 7.75) of the magnetic phase diagram of the off-stoichiometric Ni–Mn–Sn Heusler alloys was investigated in detail by DSC and magnetization measurements of the Ni40+xMn39-xSn21(x = 0, 2, 4, 6 and 8 at.%) alloys. The alloys show a stable austenitic phase without any martensitic transformation down to 5 K even after heat treatment. The Curie temperature exhibits a broad maximum over a large composition range. The evolution of the magnetic moment with the electron concentration fits the data of previous studies and confirms the peak-like dependence in the extended range of e/a values predicted by ab initio calculations. Finally, the explored part of the moment versus e/a curve can be explained in terms of a localized magnetic moment model and full atomic order in the alloys.

  19. Effects of R-site compositions on the meta-magnetic behavior of Tb1 - xPrx(Fe0.4Co0.6)1.88C0.05 (x = 0, 0.8, and 1)

    NASA Astrophysics Data System (ADS)

    Huang, Jun-Wei; Xia, Zheng-Cai; Cheng, Gang; Shi, Li-Ran; Jin, Zhao; Shang, Cui; Wei, Meng

    2015-10-01

    We investigate the low-temperature magnetic properties of intermetallic compounds Tb1 - xPrx(Fe0.4Co0.6)1.88C0.05 (x = 0, 0.8, and 1) by detailed magnetization measurements. Obvious temperature- and field-induced irreversibilities suggest the coexistence of multiple magnetic phases. Sharp magnetization jumps across the antiferromagnetic to ferromagnetic transition are observed only in the Pr-containing samples, indicating that the behavior of the avalanche-like growth of ferromagnetic clusters is mainly related to the light lanthanide Pr ions. In addition, the time relaxation, field sweep rate, and cooling field dependence of magnetization jumps in the sample with x = 1 are consistent with those in the martensitic scenario. Project supported by the National Natural Science Foundation of China (Grant No. 11104091) and the Funds from Provincial Key Laboratory of Information Materials, Guilin University of Electronic Technology, Guangxi Zhuang Autonomous Region, China (Grant No. 1210908-05-K).

  20. Slow Thermodynamics in the Phase Separated State of the Bilayered Manganite (La0.4Pr0.6)1.2Sr1.8Mn2O7

    NASA Astrophysics Data System (ADS)

    Taniguchi, Haruka; Nakamura, Yuma; Konno, Takahisa; Matsukawa, Michiaki; Suryanarayanan, Ramanathaan

    Bilayered perovskite (La0.4Pr0.6)1.2Sr1.8Mn2O7 exhibits a field-induced paramagnetic-insulator to ferromagnetic- metal transition, and a phase-separated state is realized after the field is switched off. In order to clarify the thermodynamic properties of the phase-separated state which is a common feature in many mangan- ites, we performed specific heat measurement with field along the magnetization easy axis. We have revealed that the remanent specifc heat might exhibit a stretched exponential decay and the relaxation time is remarkably long. These results indicate the importance of magnetic frustration originating from the competition between double-exchange interaction and superexchange interaction.

  1. I. Infrared Spectrum of Matrix Isolated Triplet Phenylnitrene. I. Photolysis of Matrix Isolated Quadricyclanone. III. Photolysis of Matrix Isolated 1,3,4,5,6,9-HEXADEUTERIO -7,8-DIAZATETRACYCLO 4.3.0.0(3,5).0(4,9) NON-7-EN-2-ONE

    NASA Astrophysics Data System (ADS)

    Hayes, James Clayton

    Photolysis (lambda = 334 nm) of matrix isolated phenyl azide (1) at 10 K generated triplet phenylnitrene (2) and 1-azacyclohepta-1,2,4,6-tetraene (15) in a ratio of 2:1 even at short (5 sec.) irradiation times. Under the same conditions, the first infrared spectrum of triplet phenylnitrene (2T) was obtained. Photolysis of matrix isolated quadricyclanone (58) at 10 K generated tropone (65) benzene (66) and ketene (67). No oxyallyl (31) was observed from the low temperature matrix isolation experiments. Matrix isolated 1,3,4,5,6,9-hexadeuterio-7,8-diazatetracyclo(4.3.0.0 ^{3,5}.0^ {4,9}) non-7-en-2-one (74) was irradiated in argon and nitrogen matrices to determine if the hexadeuterated photoproduct, 1,2,3,4,5,6-hexadeuteriobicyclo(2.2.1) heptan -7-one (73), would vibrationally cool more rapidly in the nitrogen matrix than in the argon matrix due to increased coupling of similar vibrational modes of 73 and the nitrogen matrix. Similar irradiations in frozen deuterated NMR solvents and analysis by low temperature ^1 H NMR were conducted. Evidence of increased vibrational coupling of similar vibrational modes by IR and NMR analysis was inconclusive.

  2. Precursor solution additives improve desiccated La0.6Sr0.4Co0.8Fe0.2O3-x infiltrated solid oxide fuel cell cathode performance

    NASA Astrophysics Data System (ADS)

    Burye, Theodore E.; Nicholas, Jason D.

    2016-01-01

    Here, the addition of the surfactant Triton X-100 or the chelating agent citric acid to Solid Oxide Fuel Cell (SOFC) La0.6Sr0.4Co0.8Fe0.2O3-x (LSCF) precursor nitrate solutions is shown via scanning electron microscopy (SEM) and X-ray diffraction (XRD) to reduce average infiltrate nano-particle size and improve infiltrate phase purity. In addition, the desiccation of LSCF precursor solutions containing the aforementioned organic solution additives further reduces the average LSCF infiltrate nano-particle size and improves the low-temperature infiltrate phase purity. In particular, CaCl2-desiccation reduces the average size of Triton X-100 derived (TXD) LSCF particles fired at 700 °C from 48 to 22 nm, and reduces the average size of citric acid derived LSCF particles fired at 700 °C from 50 to 41 nm. Modeling and electrochemical impedance spectroscopy (EIS) tests indicate that particle size reductions alone are responsible for desiccation-induced cathode performance improvements such as CaCl2-desiccated TXD La0.6Sr0.4Co0.8Fe0.2O3-x - Ce0.9Gd0.1O1.95 (LSCF-GDC) cathodes reaching a polarization resistance of 0.17 Ωcm2 at 540 °C, compared to 600 °C for undesiccated TXD LSCF-GDC cathodes. This excellent low-temperature performance, combined with a low open-circuit 540 °C degradation rate, suggests that the desiccation of organic-additive-containing infiltrate precursor solutions may be useful for the development of durable, high-power, low-temperature SOFCs.

  3. Adaptive 4-8 Texture Hierarchies

    SciTech Connect

    Hwa, L M; Duchaineau, M A; Joy, K I

    2004-08-02

    We address the texture level-of-detail problem for extremely large surfaces such as terrain during real-time, view-dependent rendering. A novel texture hierarchy is introduced based on 4-8 refinement of raster tiles, in which the texture grids in effect rotate 45 degrees for each level of refinement. This hierarchy provides twice as many levels of detail as conventional quad-tree-style refinement schemes such as mipmaps, and thus provides per-pixel view-dependent filtering that is twice as close to the ideal cutoff frequency for an average pixel. Because of this more gradual change in low-pass filtering, and due to the more precise emulation of the ideal cutoff frequency, we find in practice that the transitions between texture levels of detail are not perceptible. This allows rendering systems to avoid the complexity and performance costs of per-pixel blending between texture levels of detail. The 4-8 texturing scheme is integrated into a variant of the Real-time Optimally Adapting Meshes (ROAM) algorithm for view-dependent multiresolution mesh generation. Improvements to ROAM included here are: the diamond data structure as a streamlined replacement for the triangle bintree elements, the use of low-pass-filtered geometry patches in place of individual triangles, integration of 4-8 textures, and a simple out-of-core data access mechanism for texture and geometry tiles.

  4. 8. View Southeast, showing front elevation of Brewery (Buildings 6 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. View Southeast, showing front elevation of Brewery (Buildings 6 and 7 are not visible - behind Brewery) - Weissner Brewery, Building Nos. 6 & 7, 1700 North Gay Street, Baltimore, Independent City, MD

  5. Mild hydrothermal synthesis, crystal structure, thermal behavior, spectroscopic and magnetic properties of the (NH{sub 4})[Fe(AsO{sub 4}){sub 1-x}(PO{sub 4}){sub x}F] (x=0.3, 0.6, 0.8) series. Thermal transformation of (NH{sub 4})[Fe(AsO{sub 4}){sub 0.7}(PO{sub 4}){sub 0.3}F] into the textural porous orthorhombic Fe(AsO{sub 4}){sub 0.7}(PO{sub 4}){sub 0.3}

    SciTech Connect

    Berrocal, Teresa

    2009-04-15

    The (NH{sub 4})[Fe(AsO{sub 4}){sub 1-x}(PO{sub 4}){sub x}F] (x=0.3, 0.6, 0.8) series of compounds has been synthesized under mild hydrothermal conditions. The compounds crystallize in the orthorhombic Pna2{sub 1} space group, with the unit-cell parameters a=13.1718(1), b=6.5966(6), c=10.797(1) A for x=0.3; a=13.081(1), b=6.5341(6), c=10.713(1) A for x=0.6 and a=13.0329(9), b=6.4994(4), c=10.6702(6) A for x=0.8, with the volumes 938.6(1), 915.7(1) and 903.8(1) A{sup 3}, respectively, with Z=8. Single crystals of (NH{sub 4})[Fe(AsO{sub 4}){sub 0.7}(PO{sub 4}){sub 0.3}F] heated under air atmosphere at 465 deg. C remain as single crystals, changing the composition to Fe(AsO{sub 4}){sub 0.7}(PO{sub 4}){sub 0.3}. This later phase belongs to the orthorhombic Imam space group, with the unit cell parameters a=13.328(2), b=6.5114(5), c=10.703(1) A, V=928.9(2) A{sup 3} and Z=12. The crystal structure of the ammonium phases consists of a KTP three-dimensional framework constructed by chains formed by alternating Fe(2)O{sub 4}F{sub 2} or Fe(1)O{sub 4}F{sub 2} octahedra and As/P(2)O{sub 4} or As/P(1)O{sub 4} tetrahedra, respectively. These octahedra and tetrahedra are linked by a common oxygen vertex. The chains run along the 'a' and 'b' crystallographic axes. The crystal structure of Fe(AsO{sub 4}){sub 0.7}(PO{sub 4}){sub 0.3} is a three-dimensional skeleton derived from that of the precursor, formed from (100) sheets stacked along the [001] direction, and interconnected by chains of alternating Fe(2)O{sub 6} octahedra and As/P(2)O{sub 4} tetrahedra sharing a vertex in the 'a' direction. Transmission electronic microscopy of this compound indicates the existence of unconnected external cavities with a BET surface area of 3.91(3) m{sup 2} g{sup -1}. The diffuse reflectance spectra in the visible region show the forbidden electronic transitions characteristic of the Fe(III) d{sup 5}-high spin cation in slightly distorted octahedral geometry, for all the compounds. The ESR spectra

  6. Highly active La0.4Sr0.6Co0.8Fe0.2O3-δ nanocatalyst for oxygen reduction in intermediate temperature-solid oxide fuel cells

    NASA Astrophysics Data System (ADS)

    Chanquía, Corina M.; Mogni, Liliana; Troiani, Horacio E.; Caneiro, Alberto

    2014-12-01

    Pure-phase La0.4Sr0.6Co0.8Fe0.2O3-δ (LSCF) nanocrystallites were successfully synthesized by the combustion method, by employing glycine as fuel and complexing agent, and ammonium nitrate as combustion trigger. The morphological and structural characterization of the LSCF nanopowders was performed by using X-ray diffraction, N2 physisorption and electron microscopy. The LSCF nanopowder consists of interconnected nanocrystallites (∼45 nm) forming a sponge-like structure with meso and macropores, being its specific surface area around 10 m2 g-1. Crystalline structural analyses show that the LSCF nanopowder presents cubic symmetry in the Pm-3m space group. By employing the spin coating technique and different thermal treatments, symmetrical cells with different electrode crystallite size (45 and 685 nm) were built, by using La0.8Sr0.2Ga0.8Mg0.2O3-δ as electrolyte. Electrochemical impedance spectroscopy measurements were performed varying temperature and pO2. The area specific resistance of the nanostructured sample (45 nm) decreases by two orders of magnitude with respect to the submicrostructured sample (685 nm), reaching values as low as 0.8 Ω cm2 at 450 °C. This improvement is attributed to the cathode morphology optimization in the nanoscale, i.e., enlargement of the exposed surface area and shortening of the oxygen diffusion paths, which reduce the polarization resistance associated to the surface exchange and O-ion bulk diffusion process.

  7. Formation of Polyynes C4H2, C6H2, C8H2, and C10H2 from Reactions of C2H, C4H, C6H, and C8H Radicals with C2H2.

    PubMed

    Sun, Yi-Lun; Huang, Wen-Jian; Lee, Shih-Huang

    2015-10-15

    Some of the polyynes (HC2n+2H, 1 ≤ n ≤ 4) are observable in planetary atmospheres, interstellar space, and flames. Polyynes are proposed to play an important role in synthesis of large carbonaceous molecules. We explore the dynamics of reactions of C2nH (n = 1-4) radicals with C2H2 by interrogating time-of-flight spectra and photoionization efficiency spectra of products C2n+2H2. The reactions of n = 2-4 were investigated for the first time. The translational energy release is biased to low energy but extends to the energetic limit of product HC2n+2H + H, corresponding to a fraction of 0.34-0.36 on translational energy. Product C2n+2H2 has a deconvoluted ionization threshold in good agreement with the ionization energy of polyynes. The quantum chemical calculations support the experimental observations. This work verifies that the title reaction is an important source for formation of polyynes that have been observed in interstellar/circumstellar media and combustion processes. PMID:26722787

  8. 43 CFR 4.452-6 - Evidence.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Evidence. 4.452-6 Section 4.452-6 Public... Fact § 4.452-6 Evidence. (a) All oral testimony shall be under oath and witnesses shall be subject to cross-examination. The administrative law judge may question any witness. Documentary evidence may...

  9. 43 CFR 4.452-6 - Evidence.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Evidence. 4.452-6 Section 4.452-6 Public... Fact § 4.452-6 Evidence. (a) All oral testimony shall be under oath and witnesses shall be subject to cross-examination. The administrative law judge may question any witness. Documentary evidence may...

  10. 43 CFR 4.452-6 - Evidence.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Evidence. 4.452-6 Section 4.452-6 Public... Fact § 4.452-6 Evidence. (a) All oral testimony shall be under oath and witnesses shall be subject to cross-examination. The administrative law judge may question any witness. Documentary evidence may...

  11. 43 CFR 4.452-6 - Evidence.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Evidence. 4.452-6 Section 4.452-6 Public... Fact § 4.452-6 Evidence. (a) All oral testimony shall be under oath and witnesses shall be subject to cross-examination. The administrative law judge may question any witness. Documentary evidence may...

  12. 27 CFR 6.4 - Jurisdictional limits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Jurisdictional limits. 6.4 Section 6.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Scope of Regulations § 6.4 Jurisdictional limits. (a) General. The regulations in this part apply where:...

  13. 27 CFR 6.4 - Jurisdictional limits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Jurisdictional limits. 6.4 Section 6.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Scope of Regulations § 6.4 Jurisdictional limits. (a) General. The regulations in this part apply where:...

  14. 27 CFR 6.4 - Jurisdictional limits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Jurisdictional limits. 6.4 Section 6.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL âTIED-HOUSEâ Scope of Regulations § 6.4 Jurisdictional limits. (a) General. The regulations in this part apply where:...

  15. 27 CFR 6.4 - Jurisdictional limits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Jurisdictional limits. 6.4 Section 6.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Scope of Regulations § 6.4 Jurisdictional limits. (a) General. The regulations in this part apply where:...

  16. 27 CFR 6.4 - Jurisdictional limits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Jurisdictional limits. 6.4 Section 6.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL âTIED-HOUSEâ Scope of Regulations § 6.4 Jurisdictional limits. (a) General. The regulations in this part apply where:...

  17. 42 CFR 6.4 - Covered individuals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Covered individuals. 6.4 Section 6.4 Public Health... COVERAGE OF CERTAIN GRANTEES AND INDIVIDUALS § 6.4 Covered individuals. (a) Officers and employees of a... if they meet the requirements of section 224(g)(5) of the Act. (c) An individual physician or...

  18. La(0.4)Ba(0.6)Fe(0.8)Zn(0.2)O(3-delta) as cathode in solid oxide fuel cells for simultaneous NO reduction and electricity generation.

    PubMed

    Zhou, Renjie; Bu, Yunfei; Xu, Dandan; Zhong, Qin

    2014-01-01

    A perovskite-type oxide La(0.4)Ba(0.6)Fe(0.8)Zn(0.2)O(3-delta) (LBFZ) was investigated as the cathode material for simultaneous NO reduction and electricity generation in solid oxide fuel cells (SOFCs). The microstructure of LBFZ was demonstrated by X-ray diffraction and scanning electron microscopy. The results showed that a single cubic perovskite LBFZ was formed after calcined at 1100 degrees C. Meanwhile, the solid-state reaction between LBFZ and Ce(0.8)Sm(0.2)O(1.9) (SDC) at 900 degrees C was negligible. To measure the electrochemical properties, SOFC units were constructed with Sm(0.9)Sr(0.1)Cr(0.5)Fe(0.5)O3 as the anode, SDC as the electrolyte and LBFZ as the cathode. The maximum power density increased with the increasing NO concentration and temperature. The cell resistance is mainly due to the cathodic polarization resistance.

  19. Crystal structure of (1S,3R,8R,9R,10S)-2,4,6-tris­(2,2-di­chloro-3,7,7,10-tetra­methyl­tri­cyclo­[6.4.0.01,3]dodec-9-yl)cyclo­triboroxane

    PubMed Central

    Benharref, Ahmed; El Ammari, Lahcen; Saadi, Mohamed; Mazoir, Noureddine; Berraho, Moha

    2015-01-01

    The title compound, C48H75B3Cl6O3, was synthesized in two steps from β-himachalene (3,5,5,9-tetra­methyl-2,4a,5,6,7,8-hexa­hydro-1H-benzo­cyclo­hept­ene), which was isolated from the essential oil of the Atlas cedar (Cedrus Atlantica). The mol­ecule consists of an almost planar cyclo­triboroxane ring [maximum deviation = 0.036 (2) Å] linked to three identical fused ring systems with different conformations. Each of the three attached ring systems is built up from a seven-membered ring to which a six- and a three-membered ring are fused. The three six-membered rings have a twist-boat conformation, whereas the seven-membered rings display boat, chair and twist-boat conformations. The dihedral angles between the central boroxane ring and the mean planes of the attached six-membered rings are 63.67 (18), 54.89 (2) and 56.57 (19)°. The crystal packing is governed only by van der Waals inter­actions. PMID:26396761

  20. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commissioner for Examinations as provided in 8 CFR 103.3. (7) Requirements for alien entrepreneurs. An alien... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION...

  1. 44 CFR 6.8 - Subpoena and other legal demands.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... other legal demands. Access to records in systems of records by subpoena or other legal process shall be... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Subpoena and other legal demands. 6.8 Section 6.8 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT...

  2. 1 CFR 8.6 - Forms of publication.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Forms of publication. 8.6 Section 8.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF... following formats: (1) Paper; (2) Microfiche; and (3) Online on GPO Access (44 US.C. 4101). (b) The...

  3. 1 CFR 8.6 - Forms of publication.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Forms of publication. 8.6 Section 8.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF... following formats: (1) Paper; (2) Microfiche; and (3) Online on GPO Access (44 US.C. 4101). (b) The...

  4. 1 CFR 8.6 - Forms of publication.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Forms of publication. 8.6 Section 8.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF... following formats: (1) Paper; (2) Microfiche; and (3) Online on GPO Access (44 US.C. 4101). (b) The...

  5. 1 CFR 8.6 - Forms of publication.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Forms of publication. 8.6 Section 8.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF... following formats: (1) Paper; (2) Microfiche; and (3) Online on GPO Access (44 US.C. 4101). (b) The...

  6. 1 CFR 8.6 - Forms of publication.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Forms of publication. 8.6 Section 8.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF... following formats: (1) Paper; (2) Microfiche; and (3) Online on GPO Access (44 US.C. 4101). (b) The...

  7. DFT studies on a high-energy density cage compound 1, 3, 5, 7, 9, 11-hexo(N(CH3)NO2)-2, 4, 6, 8, 10, 12-hexaazatetracyclo[5, 5, 0, 0, 0] dodecane

    NASA Astrophysics Data System (ADS)

    Li, Xiao-Hong; Yong, Yong-Liang; Zhang, Xian-Zhou

    2014-04-01

    The infrared and Raman spectra, heat of formation (HOF) and thermodynamic properties were investigated by B3LYP/6-31G** method for a new designed polynitro cage compound 1,3,5,7,9,11-hexo(N(CH3)NO2)-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0,0]dodecane. The detonation velocity (D) and pressure (P) were predicted by the Kamlet-Jacobs equations based on the theoretical density and condensed HOF. The bond dissociation energies and bond orders for the weakest bonds were analysed to investigate the thermal stability of the title compound. The computational result shows that the detonation velocity and pressure of the title compound are superior to those of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), but inferior to those of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX) and hexanitrohexaazaisowurtzitane (HNIW). And the analysis of thermal stability shows that the first step of pyrolysis is the rupture of the N7-NO2 bond. The crystal structure obtained by molecular mechanics belongs to the P21 space group, with the lattice parameters Z = 2, a = 11.8246 Å, b = 10.4632 Å, c = 15.9713 Å, ρ = 1.98 g cm-3.

  8. 48 CFR 6.204 - Section 8(a) competition.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Section 8(a) competition... ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 6.204 Section 8(a) competition. (a) To fulfill statutory requirements relating to section 8(a) of the...

  9. 48 CFR 6.204 - Section 8(a) competition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Section 8(a) competition... ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 6.204 Section 8(a) competition. (a) To fulfill statutory requirements relating to section 8(a) of the...

  10. 48 CFR 6.204 - Section 8(a) competition.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Section 8(a) competition... ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 6.204 Section 8(a) competition. (a) To fulfill statutory requirements relating to section 8(a) of the...

  11. 48 CFR 6.204 - Section 8(a) competition.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Section 8(a) competition... ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 6.204 Section 8(a) competition. (a) To fulfill statutory requirements relating to section 8(a) of the...

  12. 48 CFR 6.204 - Section 8(a) competition.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Section 8(a) competition... ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 6.204 Section 8(a) competition. (a) To fulfill statutory requirements relating to section 8(a) of the...

  13. 6 CFR 13.8 - Service of Complaint.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Service of Complaint. 13.8 Section 13.8 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.8 Service of Complaint. (a) Service of a Complaint must be Made by certified or registered mail or...

  14. 6 CFR 13.8 - Service of Complaint.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Service of Complaint. 13.8 Section 13.8 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.8 Service of Complaint. (a) Service of a Complaint must be Made by certified or registered mail or...

  15. 6 CFR 25.8 - Government contractor Defense.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Government contractor Defense. 25.8 Section 25.8...-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.8 Government contractor Defense. (a) Criteria for... applicability of the government contractor defense. In determining whether to issue such Certification,...

  16. 6 CFR 25.8 - Government contractor Defense.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Government contractor Defense. 25.8 Section 25.8...-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.8 Government contractor Defense. (a) Criteria for... applicability of the government contractor defense. In determining whether to issue such Certification,...

  17. 40 CFR 721.10541 - 5,2,6-(Iminomethenimino)-1H-imidazo[4,5-b]pyrazine, octahydro-1,3,4,7,8,10-hexanitro-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL... the requirements of § 721.63(a)(4): a National Institute for Occupational Safety and Health...

  18. Evaluation of the characteristics of the organic thin film solar cell fabricated by poly[4,8-bis(2-ethylhexyloxy)-benzo[1,2-b:4,5-b']dithiophene-2,6-diyl-alt-(4-octanoyl-5-fluoro-thieno[3,4-b]thiophene-2-carboxylate)-2,6-diyl]/[6,6]-phenyl-C71-butyric acid methyl ester

    NASA Astrophysics Data System (ADS)

    Komura, Tatsushi; Santhakumar, Kannappan; Kumar, Palanisamy; Shin, Paik-Kyun; Kojima, Kenzo; Ochiai, Shizuyasu

    2012-09-01

    Solar energy is the most abundant and reliable source of energy and we have to provide for the multi-terawatt challenge we are facing. In recent years organic photovoltaic's have become one of the most interesting research areas due to their potential towards a cheap and broad applicability. We report the optical and electrical properties of PBDTTT-CF: PC71BM bulk hetero-junction (BHJ) solar cell. The devices were prepared by spin coating technique with the device structure of Glass/ITO/PEDOT: PSS/Active layer/Al. The ratio of polymer donor and fullerene acceptor varied between 1:1 to 1:4. Optical absorption spectroscopy measurements of the films indicated absorption peaks in the range from 500-800 nm which were attributed to PBDTTT-CF. The surface morphology of the active layers deposited was examined using Atomic Force Microscopy. The current density (J)-voltage (V) characteristics of the PBDTTT-CF: PC71BM bulk hetero-junction solar cells were studied. The devices fabricated using the selective active layer show overall power conversion efficiency of 3%.

  19. Degradation of (La0.6Sr0.4)0.95(Co0.2Fe0.8)O3-δ Solid Oxide Fuel Cell Cathodes at the Nanometer Scale and below.

    PubMed

    Ni, Na; Cooper, Samuel J; Williams, Robert; Kemen, Nils; McComb, David W; Skinner, Stephen J

    2016-07-13

    The degradation of intermediate temperature solid oxide fuel cell (ITSOFC) cathodes has been identified as a major issue limiting the development of ITSOFCs as high efficiency energy conversion devices. In this work, the effect of Cr poisoning on (La0.6Sr0.4)0.95(Co0.2Fe0.8)O3-δ (LSCF6428), a particularly promising ITSOFC cathode material, was investigated on symmetrical cells using electrochemical impedance spectroscopy and multiscale structural/chemical analysis by advanced electron and ion microscopy. The systematic combination of bulk and high-resolution analysis on the same cells allows, for the first time, direct correlation of Cr induced performance degradation with subtle and localized structural/chemical changes of the cathode down to the atomic scale. Up to 2 orders of magnitude reduction in conductivity, oxygen surface exchange rate, and diffusivity were observed in Cr poisoned LSCF6428 samples. These effects are associated with the formation of nanometer size SrCrO4; grain boundary segregation of Cr; enhanced B-site element exsolution (both Fe and Co); and reduction in the Fe valence, the latter two being related to Cr substitution in LSCF. The finding that significant degradation of the cathode happens before obvious microscale change points to new critical SOFC degradation mechanisms effective at the nanometer scale and below. PMID:27336290

  20. Degradation of (La0.6Sr0.4)0.95(Co0.2Fe0.8)O3-δ Solid Oxide Fuel Cell Cathodes at the Nanometer Scale and below.

    PubMed

    Ni, Na; Cooper, Samuel J; Williams, Robert; Kemen, Nils; McComb, David W; Skinner, Stephen J

    2016-07-13

    The degradation of intermediate temperature solid oxide fuel cell (ITSOFC) cathodes has been identified as a major issue limiting the development of ITSOFCs as high efficiency energy conversion devices. In this work, the effect of Cr poisoning on (La0.6Sr0.4)0.95(Co0.2Fe0.8)O3-δ (LSCF6428), a particularly promising ITSOFC cathode material, was investigated on symmetrical cells using electrochemical impedance spectroscopy and multiscale structural/chemical analysis by advanced electron and ion microscopy. The systematic combination of bulk and high-resolution analysis on the same cells allows, for the first time, direct correlation of Cr induced performance degradation with subtle and localized structural/chemical changes of the cathode down to the atomic scale. Up to 2 orders of magnitude reduction in conductivity, oxygen surface exchange rate, and diffusivity were observed in Cr poisoned LSCF6428 samples. These effects are associated with the formation of nanometer size SrCrO4; grain boundary segregation of Cr; enhanced B-site element exsolution (both Fe and Co); and reduction in the Fe valence, the latter two being related to Cr substitution in LSCF. The finding that significant degradation of the cathode happens before obvious microscale change points to new critical SOFC degradation mechanisms effective at the nanometer scale and below.

  1. Synthesis and characterization of La0.6Sr0.4Fe0.8Cu0.2O3-δ oxide as cathode for Intermediate Temperature Solid Oxide Fuel Cells

    NASA Astrophysics Data System (ADS)

    Vázquez, Santiago; Davyt, Sebastián; Basbus, Juan F.; Soldati, Analía L.; Amaya, Alejandro; Serquis, Adriana; Faccio, Ricardo; Suescun, Leopoldo

    2015-08-01

    Nanocrystalline La0.6Sr0.4Fe0.8Cu0.2O3-δ (LSFCu) material was synthetized by combustion method using EDTA as fuel/chelating agent and NH4NO3 as combustion promoter. Structural characterization using thermodiffraction data allowed to determine a reversible phase transition at 425 °C from a low temperature R-3c phase to a high temperature Pm-3m phase and to calculate the thermal expansion coefficient (TEC) of both phases. Important characteristics for cathode application as electronic conductivity and chemical compatibility with Ce0.9Gd0.1O2-δ (CGO) electrolyte were evaluated. LSFCu presented a p-type conductor behavior with maximum conductivity of 135 S cm-1 at 275 °C and showed a good stability with CGO electrolyte at high temperatures. This work confirmed that as prepared LSFCu has excellent microstructural characteristics and an electrical conductivity between 100 and 60 S cm-1 in the 500-700 °C range which is sufficiently high to work as intermediate temperature Solid Oxide Fuel Cells (IT-SOFCs) cathode. However a change in the thermal expansion coefficient consistent with a small oxygen loss process may affect the electrode-electrolyte interface during fabrication and operation of a SOFC.

  2. Mechanism of the antihyperlipaemic activity and pharmacokinetics of 2-chloromethyl-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4(3H)-o ne.

    PubMed

    Shishoo, C J; Gandhi, T R; Rathod, I S; Jain, K S; Goyal, R K

    1997-10-01

    The pharmacokinetics and the mechanism of action of the antihyperlipaemic compound 2-chloromethyl-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4(3H)-on e (CAS 89587-03-3, LM-1554) have been studied. Serum concentrations were determined by reverse phase HPLC using methanol : water (60 : 40) as the solvent system. The results of pharmacokinetic studies suggest that the compound LM-1554 is poorly absorbed from the gastrointestinal tract after the oral administration in dogs and rabbits. The volume of distribution (Vd) was found to be low. The poor bioavailability (3-4%) and low volume of distribution of the compound LM-1554 suggest the gastrointestinal tract as the site of action for the antihyperlipaemic activity. This hypothesis is substantiated by the observations that the compound was found active in rabbits only when administered orally and found inactive by the parenteral route. Further, the cholesterol levels were found to increase in blood samples collected from the portal vein after oral administration of cholesterol in coconut oil to rats. This increase was found to be prevented by the compound LM-1554. In conclusion, the compound LM-1554 has a potential to be developed as an antihyperlipaemic agent. The mechanism of action of the compound LM-1554 appears to consist in the inhibition of cholesterol absorption in the gastrointestinal tract. PMID:9368706

  3. Copper oxide as a synergistic catalyst for the oxygen reduction reaction on La0.6Sr0.4Co0.2Fe0.8O3-δ perovskite structured electrocatalyst

    NASA Astrophysics Data System (ADS)

    Hong, Tao; Brinkman, Kyle; Xia, Changrong

    2016-10-01

    This work presents the effect of dispersed copper oxide (CuO) nanoparticles on the oxygen reduction reaction (ORR) on a typical solid oxide fuel cell (SOFC) electrocatalyst, La0.6Sr0.4Co0.2Fe0.8O3-δ (LSCF). The ORR kinetics were enhanced by a factor up to 4 at 750 °C as demonstrated by electrical conductivity relaxation measurements used to determine the chemical surface exchange coefficient, kchem. The value of kchem increased from 2.6 × 10-5 cm s-1 to 9.3 × 10-5 cm s-1 at 750 °C when the LSCF surface was coated with submicron CuO particles. The enhanced kchem was attributed to additional reactions that occur on the CuO surface and at the LSCF-CuO-gas three-phase boundaries (3PBs) as suggested by the kchem dependence on CuO coverage and 3PB length. This enhancement was further demonstrated by the introduction of CuO nanoparticles into LSCF electrodes. CuO infiltrated electrodes reduced the interfacial polarization resistance from 2.27 Ω cm2 to 1.5 Ω cm2 at 600 °C and increased the peak power density from 0.54 W cm-2 to 0.72 W cm-2 at 650 °C. Electrochemical impedance spectroscopy indicated that the reduced resistance was due to the shrinkage of the low frequency arc, which is associated with the electrochemical surface exchange reaction.

  4. Chromium poisoning and degradation at Gd0.2Ce0.8O2-impregnated LaNi0.6Fe0.4O3-δ cathode for solid oxide fuel cell

    NASA Astrophysics Data System (ADS)

    Huang, Bo; Zhu, Xin-jian; Ren, Rui-xuan; Hu, Yi-xing; Ding, Xiao-yi; Liu, Ye-bin; Liu, Zong-yao

    2012-10-01

    The degradation of cathode performances by chromium poisoning is studied at two cathodes LaNi0.6Fe0.4O3-δ (LNF) and 21.3 wt.% Gd0.2Ce0.8O2 (GDC)-impregnated LaNi0.6Fe0.4O3-δ on the scandia stabilized zirconia (ScSZ) electrolyte. Specific polarization resistance (Rp) increases with time to the power of 1/3 and 1/5 in LNF and 21.3 wt.% GDC-impregnated LNF cathode after operating under a cathodic current density of 50 mA cm-2 under exposure of Cr vapors at 750 °C for 370 h and 1042 h, respectively. electrochemical impedance spectroscopy (EIS) illustrate that LNF exhibits far greater Rp than that of 21.3 wt.%GDC-impregnated LNF under exposure of Cr vapors due to strong Cr deposition at LNF/ScSZ interface. No significant degradation in performance has been observed after 1042 h of operating under a cathodic current density of 50 mA cm-2 under exposure of Cr vapors at 750 °C due to very little Cr deposition at 21.3 wt.%GDC-impregnated LNF/ScSZ interface, suggesting little poisoning effect for O2 reduction on 21.3 wt.%GDC-impregnated LNF cathode. The results demonstrate that 21.3 wt.%GDC-impregnated LNF cathode has a high resistance toward Cr deposition and high tolerance toward Cr poisoning.

  5. CF, CF{sub 2} and SiF Densities in Inductively Driven Discharges Containing C{sub 2}F{sub 6}, C{sub 4}F{sub 8} and CHF{sub 3}

    SciTech Connect

    HEBNER,GREGORY A.

    2000-06-12

    Laser induced fluorescence was used to measure the spatially resolved CF, CF{sub 2} and SiF radical density in inductively driven discharges containing fluorocarbon gases. Measurements of the spatially resolved CF density were performed in C{sub 2}F{sub 6} and CHF{sub 3} containing discharges as functions of inductive power, pressure and bias condition on a silicon substrate. In addition, CF rotational temperatures were calculated, assuming saturated spectra. Measurements of the spatially resolved CF{sub 2} and SiF density were performed in C{sub 4}F{sub 8}, C{sub 2}F{sub 6} and CHF{sub 3} containing discharges as functions of inductive power, pressure and bias condition. SiF rotational temperatures were also estimated. As the induction coil power was increased, the SiF density in the center (r = 0 cm) increased while the CF{sub 2} density decreased and the CF density slightly decreased. In all cases, the radical density in the center of the glow increased with pressure changes from 5 to 30 mTorr while changes in the bias power had little influence on any of the measured radical densities. The spatial distribution of the CF and SiF density peaked in the center of the discharge. The CF{sub 2} density had a local maximum in the center of the plasma with a decreasing density at the edge of the glow. However, the CF{sub 2} density outside the glow region was a factor of 2--6 higher than the density inside the glow region, depending on the gas. CF and SiF rotational temperatures were between 450 and 750 K.

  6. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a)...

  7. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a)...

  8. 8 CFR 274a.6 - State employment agencies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false State employment agencies. 274a.6 Section 274a.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROL OF EMPLOYMENT OF ALIENS Employer Requirements § 274a.6 State employment agencies. (a) General. Pursuant...

  9. 8 CFR 274a.6 - State employment agencies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false State employment agencies. 274a.6 Section 274a.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROL OF EMPLOYMENT OF ALIENS Employer Requirements § 274a.6 State employment agencies. (a) General. Pursuant...

  10. 8 CFR 274a.6 - State employment agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false State employment agencies. 274a.6 Section 274a.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROL OF EMPLOYMENT OF ALIENS Employer Requirements § 274a.6 State employment agencies. (a) General. Pursuant...

  11. 8 CFR 235.6 - Referral to immigration judge.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Referral to immigration judge. 235.6 Section 235.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS INSPECTION OF PERSONS APPLYING FOR ADMISSION § 235.6 Referral to immigration judge. (a) Notice—(1) Referral by Form...

  12. 8 CFR 286.6 - Maintenance of records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Maintenance of records. 286.6 Section 286.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.6 Maintenance of records. Each collector and remitter shall maintain records necessary for...

  13. 8 CFR 286.6 - Maintenance of records.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Maintenance of records. 286.6 Section 286.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.6 Maintenance of records. Each collector and remitter shall maintain records necessary for...

  14. 8 CFR 1235.6 - Referral to immigration judge.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Referral to immigration judge. 1235.6 Section 1235.6 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS INSPECTION OF PERSONS APPLYING FOR ADMISSION § 1235.6 Referral to immigration...

  15. 8 CFR 235.6 - Referral to immigration judge.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Referral to immigration judge. 235.6 Section 235.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS INSPECTION OF PERSONS APPLYING FOR ADMISSION § 235.6 Referral to immigration judge. (a) Notice—(1) Referral by Form...

  16. 8 CFR 286.6 - Maintenance of records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Maintenance of records. 286.6 Section 286.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.6 Maintenance of records. Each collector and remitter shall maintain records necessary for...

  17. 8 CFR 1235.6 - Referral to immigration judge.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Referral to immigration judge. 1235.6 Section 1235.6 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS INSPECTION OF PERSONS APPLYING FOR ADMISSION § 1235.6 Referral to immigration...

  18. 8 CFR 235.6 - Referral to immigration judge.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Referral to immigration judge. 235.6 Section 235.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS INSPECTION OF PERSONS APPLYING FOR ADMISSION § 235.6 Referral to immigration judge. (a) Notice—(1) Referral by Form...

  19. 8 CFR 235.6 - Referral to immigration judge.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Referral to immigration judge. 235.6 Section 235.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS INSPECTION OF PERSONS APPLYING FOR ADMISSION § 235.6 Referral to immigration judge. (a) Notice—(1) Referral by Form...

  20. 8 CFR 235.6 - Referral to immigration judge.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Referral to immigration judge. 235.6 Section 235.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS INSPECTION OF PERSONS APPLYING FOR ADMISSION § 235.6 Referral to immigration judge. (a) Notice—(1) Referral by Form...