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Sample records for 4-in focal point

  1. Focus in Grade 1: Teaching with Curriculum Focal Points

    ERIC Educational Resources Information Center

    Fuson, Karen; Clements, Douglas; Beckmann, Sybilla

    2010-01-01

    "Focus in Grade 1: Teaching with Curriculum Focal Points" describes and illustrates learning paths for the mathematical concepts and skills of each grade 1 Focal Point as presented in Curriculum Focal Points for Prekindergarten through Grade 8 Mathematics. It includes representational supports for teaching and learning that can facilitate…

  2. Focus in Grade 2: Teaching with Curriculum Focal Points

    ERIC Educational Resources Information Center

    National Council of Teachers of Mathematics, 2011

    2011-01-01

    "Focus in Grade 2: Teaching with Curriculum Focal Points" describes and illustrates learning paths for the mathematical concepts and skills of each grade 2 Focal Point as presented in 'Curriculum Focal Points for Prekindergarten through Grade 8 Mathematics". It includes representational supports for teaching and learning that can facilitate…

  3. Focal Point Inside the Vacuum Chamber for Solar Thermal Propulsion

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Researchers at the Marshall Space Flight Center (MSFC) have designed, fabricated, and tested the first solar thermal engine, a non-chemical rocket engine that produces lower thrust but has better thrust efficiency than a chemical combustion engine. MSFC turned to solar thermal propulsion in the early 1990s due to its simplicity, safety, low cost, and commonality with other propulsion systems. Solar thermal propulsion works by acquiring and redirecting solar energy to heat a propellant. The 20- by 24-ft heliostat mirror (not shown in this photograph) has dual-axis control that keeps a reflection of the sunlight on an 18-ft diameter concentrator mirror, which then focuses the sunlight to a 4-in focal point inside the vacuum chamber. The focal point has 10 kilowatts of intense solar power. This photograph is a close-up view of a 4-in focal point inside the vacuum chamber at the MSFC Solar Thermal Propulsion Test facility. As part of MSFC's Space Transportation Directorate, the Propulsion Research Center serves as a national resource for research of advanced, revolutionary propulsion technologies. The mission is to move the Nation's capabilities beyond the confines of conventional chemical propulsion into an era of aircraft-like access to Earth orbit, rapid travel throughout the solar system, and exploration of interstellar space.

  4. Comprehensive Service Delivery through Senior Centers and Other Community Focal Points: A Resource Manual.

    ERIC Educational Resources Information Center

    National Council on the Aging, Inc., Washington, DC.

    This manual provides information on factors particularly relevant to focal point service delivery such as cooperative planning, interagency linkages, shared service delivery, accountability, and community relationships. An introduction describes what community focal points for service delivery are and how they are intended to fit into community…

  5. Compensation for displacement of the focal point in cone beam single photon emission computed tomography reconstruction.

    PubMed

    Cao, Z; Qian, L

    1997-04-01

    This study examined the effects of focal point displacement on image quality in cone beam single photon emission computed tomography (SPECT). A new image reconstruction algorithm that accounts for the focal point shift was derived and three shift geometries were investigated. The geometries included a lateral shift with a fixed focal length but off-center focusing, a linear axial shift with a variable focal length that depends linearly on the distance between a bin of the detector and the center of the detector, and a random axial shift with a randomly varying focal length. Computer simulation was conducted to evaluate the shift effects with a phantom that was composed of 118 small spherical sources. The results demonstrated that the lateral shift of the focal point was more critical to image quality than was the axial shift. With a 0.64 cm (1 pixel) lateral shift, noticeable artifacts was observed, while an axial shift resulted in minimal changes in image quality until it reached 8 cm (12.5 pixels). The derived reconstruction algorithm eliminated most of the artifacts caused by a fixed lateral shift or a linear axial shift of the focal point, but failed to do so for a random axial shift since the linear distribution assumed in image reconstruction did not match the random shift occurred in acquisition of the data. PMID:9291002

  6. "Torsade de pointes" tachycardia. Re-entry or focal activity?

    PubMed Central

    D'Alnoncourt, C N; Zierhut, W; Blüderitz, B

    1982-01-01

    Paroxysms of ventricular tachycardia in which the amplitude and the direction of QRS complexes change periodically are defined as "torsade de pointes" tachycardias. The mechanism of this atypical ventricular arrhythmia has not yet been elucidated. The aim of our study was to induce "torsade de pointes" tachycardia experimentally, in order to gain insight into its possible mechanism. The experiments were carried out with isolated porcine hearts, perfused by the Langendorff technique. Epicardial electrocardiograms were recorded by unipolar leads. The specific pattern of "torsade de pointes" tachycardia could be induced by stimulation of the right and left ventricles in phase. From our experimental observations we conclude that a possible cause of "torsade de pointes" tachycardia is the interaction of two ectopic ventricular foci. PMID:7104111

  7. Nonlinear optical microscopy improvement by focal-point axial modulation

    NASA Astrophysics Data System (ADS)

    Dashtabi, Mahdi Mozdoor; Massudi, Reza

    2016-05-01

    Among the most important challenges of microscopy-even more important than the resolution enhancement, especially in biological and neuroscience applications-is noninvasive and label-free imaging deeper into live scattering samples. However, the fundamental limitation on imaging depth is the signal-to-background ratio in scattering biological tissues. Here, using a vibrating microscope objective in conjunction with a lock-in amplifier, we demonstrate the background cancellation in imaging the samples surrounded by turbid and scattering media, which leads to more clear images deeper into the samples. Furthermore, this technique offers the localization and resolution enhancement as well as resolves ambiguities in signal interpretation, using a single-color laser. This technique is applicable to most nonlinear as well as some linear point-scanning optical microscopies.

  8. Focal Points, Endogenous Processes, and Exogenous Shocks in the Autism Epidemic

    PubMed Central

    Liu, Kayuet; Bearman, Peter S.

    2014-01-01

    Autism prevalence has increased rapidly in the United States during the past two decades. We have previously shown that the diffusion of information about autism through spatially proximate social relations has contributed significantly to the epidemic. This study expands on this finding by identifying the focal points for interaction that drive the proximity effect on subsequent diagnoses. We then consider how diffusion dynamics through interaction at critical focal points, in tandem with exogenous shocks, could have shaped the spatial dynamics of autism in California. We achieve these goals through an empirically calibrated simulation model of the whole population of 3- to 9-year-olds in California. We show that in the absence of interaction at these foci—principally malls and schools—we would not observe an autism epidemic. We also explore the idea that epigenetic changes affecting one generation in the distal past could shape the precise spatial patterns we observe among the next generation. PMID:26166907

  9. Novel focal point multipass cell for absorption spectroscopy on small sized atmospheric pressure plasmas.

    PubMed

    Winter, Jörn; Hänel, Mattis; Reuter, Stephan

    2016-04-01

    A novel focal point multipass cell (FPMPC) was developed, in which all laser beams propagate through a common focal point. It is exclusively constructed from standard optical elements. Main functional elements are two 90(∘) off-axis parabolic mirrors and two retroreflectors. Up to 17 laser passes are demonstrated with a near-infrared laser beam. The number of laser passes is precisely adjustable by changing the retroreflector distance. At the focal point beams are constricted to fit through an aperture of 0.8 mm. This is shown for 11 beam passes. Moreover, the fast temporal response of the cell permits investigation of transient processes with frequencies up to 10 MHz. In order to demonstrate the applicability of the FPMPC for atmospheric pressure plasma jets, laser absorption spectroscopy on the lowest excited argon state (1s5) was performed on a 1 MHz argon atmospheric pressure plasma jet. From the obtained optical depth profiles, the signal-to-noise ratio was deduced. It is shown that an elevation of the laser pass number results in an proportional increase of the signal-to-noise ratio making the FPMPC an appropriate tool for absorption spectroscopy on plasmas of small dimensions. PMID:27131664

  10. Novel focal point multipass cell for absorption spectroscopy on small sized atmospheric pressure plasmas

    NASA Astrophysics Data System (ADS)

    Winter, Jörn; Hänel, Mattis; Reuter, Stephan

    2016-04-01

    A novel focal point multipass cell (FPMPC) was developed, in which all laser beams propagate through a common focal point. It is exclusively constructed from standard optical elements. Main functional elements are two 90∘ off-axis parabolic mirrors and two retroreflectors. Up to 17 laser passes are demonstrated with a near-infrared laser beam. The number of laser passes is precisely adjustable by changing the retroreflector distance. At the focal point beams are constricted to fit through an aperture of 0.8 mm. This is shown for 11 beam passes. Moreover, the fast temporal response of the cell permits investigation of transient processes with frequencies up to 10 MHz. In order to demonstrate the applicability of the FPMPC for atmospheric pressure plasma jets, laser absorption spectroscopy on the lowest excited argon state (1s5) was performed on a 1 MHz argon atmospheric pressure plasma jet. From the obtained optical depth profiles, the signal-to-noise ratio was deduced. It is shown that an elevation of the laser pass number results in an proportional increase of the signal-to-noise ratio making the FPMPC an appropriate tool for absorption spectroscopy on plasmas of small dimensions.

  11. Accounting for uncertainty in location when detecting point sources using infrared focal plane arrays

    NASA Astrophysics Data System (ADS)

    Nichols, J. M.; Waterman, J. R.

    2016-07-01

    This work derives the modeling and detection theory required to predict the performance of an infrared focal plane array in detecting point source targets. Specifically, we focus on modeling the uncertainty associated with the location of the point source on the array. In the process we derive several new expressions related to pixel-averaged detection performance under a variety of problem assumptions. The resulting predictions are compared to standard approaches where the location is assumed fixed and known. It is further shown how to incorporate these predictions into multi-frame detection strategies.

  12. Experimental Study to Produce Multiple Focal Points of Acoustic Field for Active Path Selection of Microbubbles through Multi-bifurcation

    NASA Astrophysics Data System (ADS)

    Koda, Ren; Koido, Jun; Ito, Takumi; Mochizuki, Takashi; Masuda, Kohji; Ikeda, Seiichi; Arai, Fumihito; Miyamoto, Yoshitaka; Chiba, Toshio

    2013-07-01

    We previously reported our attempt to propel microbubbles in a flow by a primary Bjerknes force, which is a physical phenomenon where an acoustic wave pushes an obstacle along its direction of propagation. However, when ultrasound was emitted from the surface of the body, controlling bubbles in an against-flow was necessary. It is unpractical to use multiple transducers to produce the same number of focal points because single-element transducers cannot produce more than two focal points. In this study, we introduced a complex artificial blood vessel according to a capillary model and a two-dimensional (2D) array transducer to produce multiple focal points for the active control of microbubbles in an against-flow. From the results, about 15% more microbubbles were led to the desired path with multiple focal points of ultrasound relative to the no-emission case.

  13. Focal Point Theory Models for Dissecting Dynamic Duality Problems of Microbial Infections

    PubMed Central

    Huang, S.-H.; Zhou, W.; Jong, A.

    2008-01-01

    Extending along the dynamic continuum from conflict to cooperation, microbial infections always involve symbiosis (Sym) and pathogenesis (Pat). There exists a dynamic Sym-Pat duality (DSPD) in microbial infection that is the most fundamental problem in infectomics. DSPD is encoded by the genomes of both the microbes and their hosts. Three focal point (FP) theory-based game models (pure cooperative, dilemma, and pure conflict) are proposed for resolving those problems. Our health is associated with the dynamic interactions of three microbial communities (nonpathogenic microbiota (NP) (Cooperation), conditional pathogens (CP) (Dilemma), and unconditional pathogens (UP) (Conflict)) with the hosts at different health statuses. Sym and Pat can be quantitated by measuring symbiotic index (SI), which is quantitative fitness for the symbiotic partnership, and pathogenic index (PI), which is quantitative damage to the symbiotic partnership, respectively. Symbiotic point (SP), which bears analogy to FP, is a function of SI and PI. SP-converting and specific pathogen-targeting strategies can be used for the rational control of microbial infections. PMID:18350122

  14. Focal Image Plane Detection Based on Central Coordinate Point Spectral Value in Off-Axis Digital Particle Holography

    NASA Astrophysics Data System (ADS)

    Qiu, Peizhen; Deng, Lijun; Lu, Wenhui

    2015-12-01

    A method to detect the focal image plane from a single off-axis digital particle hologram is proposed. This method utilizes the central coordinate point spectral value of the reconstructed particle image as focusing criterion to detect the focal image plane. It is found that the central coordinate point spectral values come into maximum when the reconstruction distance is equal to the actual distance that was used in experiment of hologram acquisition. Numerical simulations are given to validate the feasibility and effectiveness of the proposed method. The proposed method is a potential and better option for studying three dimensional particles by using digital holography.

  15. Soluble Urokinase Receptors in Focal Segmental Glomerulosclerosis: A Review on the Scientific Point of View

    PubMed Central

    Saleem, Moin A.; Meijers, Björn

    2016-01-01

    Focal segmental glomerulosclerosis (FSGS) is one of the primary glomerular disorders in both children and adults which can progress to end-stage renal failure. Although there are genetic and secondary causes, circulating factors have also been regarded as an important factor in the pathogenesis of FSGS, because about 40% of the patients with FSGS have recurrence after renal transplantation. Soluble urokinase-type plasminogen activator receptor (suPAR) is a soluble form of uPAR, which is a membrane-bound protein linked to GPI in various immunologically active cells, including podocytes. It has recently been suggested as a potential circulating factor in FSGS by in vitro podocyte experiments, in vivo mice models, and human studies. However, there have also been controversies on this issue, because subsequent studies showed conflicting results. suPAR levels were also increased in patients with other glomerular diseases and were inversely correlated with estimated glomerular filtration rate. Nevertheless, there has been no balanced review on this issue. In this review, we compare the conflicting data on the involvement of suPAR in the pathogenesis of FSGS and shed light on interpretation by taking into account many points and the potential variables and confounders influencing serum suPAR levels. PMID:27504461

  16. Resilience and Recovery. Focal Point: Research, Policy, and Practice in Children's Mental Health. Volume 19, Number 1, Summer 2005

    ERIC Educational Resources Information Center

    Walker, Janet S., Ed.

    2005-01-01

    This issue of "Focal Point" explores the concepts of resilience and recovery and what they mean in the context of mental health care for children and adolescents. From the articles, it emerges that the terminology associated with recovery and resilience (particularly the word, recovery, itself) can be confusing and even off-putting to stakeholders…

  17. Strengthening Social Support. Focal Point: Research, Policy, and Practice in Children's Mental Health. Volume 20, Number 1, Winter 2006

    ERIC Educational Resources Information Center

    Walker, Janet S., Ed.

    2006-01-01

    This issue of "Focal Point" explores some of what is known and unknown about strengthening social support. This introduction outlines some of the major concepts and themes in research on social support, and some implications of this research for interventions in children's mental health. This sets the stage for the rest of the issue, which…

  18. Corrections. Focal Point: Research, Policy, and Practice in Children's Mental Health. Volume 20, Number 2, Summer 2006

    ERIC Educational Resources Information Center

    Walker, Janet S., Ed.

    2006-01-01

    This issue of "Focal Point" describes the need for, and provides examples of, new strategies for meeting the mental health needs of children and adolescents involved with the juvenile justice system. Articles in this issue discuss the particular need for correction in the way that the juvenile justice system interacts with youth who have mental…

  19. Workforce. Focal Point: Research, Policy, and Practice in Children's Mental Health. Volume 22, Number 1, Winter 2008

    ERIC Educational Resources Information Center

    Walker, Janet S., Ed.; Gowen, L. Kris, Ed.; Aue, Nicole, Ed.

    2008-01-01

    This issue of "Focal Point" explores how the increasing emphasis on using evidence-based practices and a "system of care" approach is driving changes in jobs and roles related to children's mental health. Articles in the issue describe how agencies and providers of services and supports have responded to these changes by creating new types of…

  20. Novel volumetric 3D display based on point light source optical reconstruction using multi focal lens array

    NASA Astrophysics Data System (ADS)

    Lee, Jin su; Lee, Mu young; Kim, Jun oh; Kim, Cheol joong; Won, Yong Hyub

    2015-03-01

    Generally, volumetric 3D display panel produce volume-filling three dimensional images. This paper discusses a volumetric 3D display based on periodical point light sources(PLSs) construction using a multi focal lens array(MFLA). The voxel of discrete 3D images is formed in the air via construction of point light source emitted by multi focal lens array. This system consists of a parallel beam, a spatial light modulator(SLM), a lens array, and a polarizing filter. The multi focal lens array is made with UV adhesive polymer droplet control using a dispersing machine. The MFLA consists of 20x20 circular lens array. Each lens aperture of the MFLA shows 300um on average. The polarizing filter is placed after the SLM and the MFLA to set in phase mostly mode. By the point spread function, the PLSs of the system are located by the focal length of each lens of the MFLA. It can also provide the moving parallax and relatively high resolution. However it has a limit of viewing angle and crosstalk by a property of each lens. In our experiment, we present the letter `C', `O', `DE' and ball's surface with the different depth location. It could be seen clearly that when CCD camera is moved to its position following as transverse axis of the display system. From our result, we expect that varifocal lens like EWOD and LC-lens can be applied for real time volumetric 3D display system.

  1. Enhancing the focal-resolution of aeroacoustic time-reversal using a point sponge-layer damping technique.

    PubMed

    Mimani, A; Doolan, C J; Medwell, P R

    2014-09-01

    This letter presents the Point-Time-Reversal-Sponge-Layer (PTRSL) technique to enhance the focal-resolution of aeroacoustic Time-Reversal (TR). A PTRSL is implemented on a square domain centered at the predicted source location and is based on damping the radial components of the incoming and outgoing fluxes propagating toward and away from the source, respectively. A PTRSL is shown to overcome the conventional half-wavelength diffraction-limit; its implementation significantly reduces the focal spot size to one-fifth of a wavelength for a monopole source. Furthermore, PTRSL reduces the focal spots of a dipole source to three-tenths of a wavelength, as compared to three-fifths without its implementation. PMID:25190421

  2. Interpolation and extrapolation of creep rupture data by the minimum commitment method. I - Focal-point convergence

    NASA Technical Reports Server (NTRS)

    Manson, S. S.; Ensign, C. R.

    1978-01-01

    The minimum commitment method has been applied to the analysis of creep-rupture data. The method is based on a parameter representing the focal point of convergence of all isothermals when extended to the long or short times necessary for such convergence to occur. The technique may be applied by manual-graphic analysis on computer code. It is illustrated for the nickel-base alloy Astroloy.

  3. Tuning the focal point of a plasmonic lens by nematic liquid crystal

    NASA Astrophysics Data System (ADS)

    Bahramipanah, M.; Abrishamian, M. S.; Mirtaheri, S. A.

    2012-12-01

    A theoretical and numerical investigation of tunable plasmonic nano-optic lens on the basis of liquid crystal are proposed as a new method of active modulating the output beam. The focal length can be controlled easily by exposing plasmonic nano-optic lens to constant external electric field. The physical principle of this phenomenon is evaluated from the phase of Fabry-Perot (F-P) resonance in slits and electro-optical effect of liquid crystal. Our numerical simulations reveal that large tuning range of the focal length up to 725 nm can be achieved. The results in this article provide a potential way to realize tunable plasmonic lens, which can be applied as an efficient element in ultrahigh nano-scale integrated photonic circuits for miniaturization and tuning purposes.

  4. Barrow Ak: A Focal Point for Ice-Albedo-Transmission Feedback Processes in Arctic Sea Ice.

    NASA Astrophysics Data System (ADS)

    Grenfell, T. C.; Perovich, D. K.; Eicken, H.

    2003-12-01

    The Arctic sea ice cover has measurably decreased in thickness, extent, and seasonal duration over the last two decades culminating in record or near-record fluctuations in 1998 and again in 2002 followed by a further strong melt season in 2003. Seasonal changes and short-term variability in the state of the ice cover and their effect on the interaction of solar radiation with the ice cover and underlying ocean are of particular importance in this context. Positive feedback processes associated with decreases in albedo and increasing transmissivity act to accelerate these changes. The rates of spring warming and summer melt as well as the length of the melt season are strongly influenced by the albedo, which in turn decreases as the melt season progresses. At the same time, increased transmission provides more energy to the upper oceanic mixed layer further increasing the potential for melting at the bottom of the ice. This ice-albedo-transmission (IAT) feedback plays a central role in modulating the heat and mass balance of the Arctic sea ice cover. Along the coastal contact zone, the feedback processes are even more complex due to interactions with the adjacent land surfaces. Indeed, this zone appears to be a focal point where the feedbacks are amplified. To understand and model the processes involved, it is necessary to determine how shortwave radiation is distributed within the ice-ocean system and how this distribution affects heat and mass balance. Analysis of this system is complicated by spatial and temporal inhomogeneity of the spring/summer ice cover, with surface conditions varying from deep snow to bare ice to melt ponds to open leads, and with ice thickness ranging from zero (open water) to ridges tens of meters thick, all within an area that is often less than one square km. Each of these categories has a different set of physical and optical properties. Treatment of the surface as a locally homogeneous medium with effective bulk optical properties

  5. [Focal point emergency departments].

    PubMed

    Lange, R; Popp, S; Erbguth, F

    2016-06-01

    The number of patients treated in hospital emergency departments in Germany has risen in recent years to approximately 20 million. This escalation also applies to the increasing numbers of patients presenting with neurological symptoms and diseases, which occur in approximately 20 % of emergency patients. In addition to patients with stroke, inflammatory or degenerative central nervous system (CNS) and peripheral nervous system (PNS) disorders who need urgent treatment, more and more patients with nonspecific complaints or conditions attend emergency departments for elective treatment, not least because timely appointments with specialist neurologists in practices could not be obtained. Neurological expertise and presence in emergency departments at the level of specialist standard are therefore indispensable for providing a professional level of treatment, which also corresponds to current legal requirements. The implementation of a generalist emergency physician in Germany, as introduced in some European countries, would mean a retrograde step for neurological expertise in emergency admission management. The discipline of neurology must work together with other emergency disciplines to improve the financing of emergency departments and provide neurologists working there with a substantive curriculum of further and continuing education in emergency-related aspects of neurology. The discipline of neurology has a responsibility to emergency patients within its range of competencies and must, therefore, strengthen and improve its role in healthcare politics and concerning organizational and personnel aspects of neurological emergencies. PMID:27167888

  6. Partnering with Families. Focal Point: A National Bulletin on Family Support and Children's Mental Health. Volume 18, Number 1, Summer 2004

    ERIC Educational Resources Information Center

    Walker, Janet S., Ed.

    2004-01-01

    The articles in this issue of "Focal Point" focus on the Research and Training Center's current work, which reflects the evolution of expectations for partnering with youth and families. Partnering successfully requires not only a philosophical commitment to the value, but also intentional, specific steps to redesign services and reallocate…

  7. Influence of focal point properties on energy transfer and plasma evolution during laser ignition process with a passively q-switched laser.

    PubMed

    Bärwinkel, Mark; Lorenz, Sebastian; Stäglich, Robert; Brüggemann, Dieter

    2016-07-11

    Miniaturized passively q-switched laser ignition systems are a promising alternative to conventional ignition sources to ensure a reliable ignition under difficult conditions. In this study the influences of focal point properties on energy transfer from laser to plasma as well as plasma formation and propagation are investigated as the first steps of the laser induced ignition process. Maximum fluence and fluence volume are introduced to characterize focal point properties for varying laser pulse energies and focusing configurations. The results show that the transferred laser energy increases with increasing maximum fluence. During laser emission plasma propagates along the beam path of the focused laser beam. Rising maximum fluence results in increased plasma volume, but expansion saturates when fluence volume reaches its maximum. PMID:27410797

  8. On a focal point instability in (B3Πg - C3Πu)N2 optogalvanic circuit with hollow cathode

    NASA Astrophysics Data System (ADS)

    Gencheva, V.

    2016-03-01

    The (B3Πg, v = 0 - C3 Πu, v = 0) N2 dynamic optogalvanic signals have been registered illuminating an Al hollow cathode lamp with a pulsed N2 laser generating at the wavelength of 337.1nm. The dynamic optogalvanic signal (DOGS) at certain discharge current of 8 mA is a harmonic oscillator due to a focal point instability produced by our optogalvanic circuit. This damped harmonic oscillator can be described as a solution of linear second order homogeneous differential equation. The oscillation frequency is estimated from the registered DOGS using Fourier synthesis. The analytical description of the damped harmonic DOGS is obtained.

  9. Interpolation and extrapolation of creep rupture data by the Minimum Commitment Method. I - Focal-point convergence. II - Oblique translation. III - Analysis of multiheats

    NASA Technical Reports Server (NTRS)

    Manson, S. S.; Ensign, C. R.

    1978-01-01

    The framework in which minimum-commitment analyses of creep-rupture data can be implemented is outlined. The approach is termed the focal point convergence method (FPCM) because the basic parameter A, also known as stability factor, is geometrically the (imaginary) focal point of convergence of all isothermals when extended to the very long or very short times necessary for such convergence to occur. The method can be implemented either by manual-graphical analysis or by computer code. The method is illustrated in detail for the nickel-base alloy Astroloy, as well as for steels, other nickel-base alloys, and aluminum alloys. The minimum-commitment concept is extended to the analysis of creep-rupture data where each isothermal is generated by an oblique translation of the 'master curve' when plotted on log rupture time and log stress axes. The oblique translation method uses the same types of functions in the FPCM. Approaches for treating multiheats on the basis of the FPCM are discussed in detail.

  10. Toward subchemical accuracy in computational thermochemistry: focal point analysis of the heat of formation of NCO and [H,N,C,O] isomers.

    PubMed

    Schuurman, Michael S; Muir, Steven R; Allen, Wesley D; Schaefer, Henry F

    2004-06-22

    In continuing pursuit of thermochemical accuracy to the level of 0.1 kcal mol(-1), the heats of formation of NCO, HNCO, HOCN, HCNO, and HONC have been rigorously determined using state-of-the-art ab initio electronic structure theory, including conventional coupled cluster methods [coupled cluster singles and doubles (CCSD), CCSD with perturbative triples (CCSD(T)), and full coupled cluster through triple excitations (CCSDT)] with large basis sets, conjoined in cases with explicitly correlated MP2-R12/A computations. Limits of valence and all-electron correlation energies were extrapolated via focal point analysis using correlation consistent basis sets of the form cc-pVXZ (X=2-6) and cc-pCVXZ (X=2-5), respectively. In order to reach subchemical accuracy targets, core correlation, spin-orbit coupling, special relativity, the diagonal Born-Oppenheimer correction, and anharmonicity in zero-point vibrational energies were accounted for. Various coupled cluster schemes for partially including connected quadruple excitations were also explored, although none of these approaches gave reliable improvements over CCSDT theory. Based on numerous, independent thermochemical paths, each designed to balance residual ab initio errors, our final proposals are DeltaH(f,0) ( composite function )(NCO)=+30.5, DeltaH(f,0) ( composite function )(HNCO)=-27.6, DeltaH(f,0) ( composite function )(HOCN)=-3.1, DeltaH(f,0) ( composite function )(HCNO)=+40.9, and DeltaH(f,0) ( composite function )(HONC)=+56.3 kcal mol(-1). The internal consistency and convergence behavior of the data suggests accuracies of +/-0.2 kcal mol(-1) in these predictions, except perhaps in the HCNO case. However, the possibility of somewhat larger systematic errors cannot be excluded, and the need for CCSDTQ [full coupled cluster through quadruple excitations] computations to eliminate remaining uncertainties is apparent. PMID:15268193

  11. Emerging infectious diseases not covered by routine vaccination in Europe in 2010-2015--the review of WHO and ECDC notifications for the National IHR Focal Point in Poland.

    PubMed

    Henszel, Łukasz; Janiec, Janusz; Izdebski, Radosław; Radziszewski, Franciszek; Polański, Piotr

    2015-01-01

    The National IHR Focal Point is a center set up by each Member State of the World Health Organization (WHO) in accordance with the International Health Regulations (2005). The International Health Regulations (IHR) were adopted on 23 May 2005 at the World Health Assembly and entered into force since 15 June 2007 as the legal instrument designed to help protect all countries from uncontrolled international spread of diseases and other urgent public health threats. According to Article 2 of IHR the purpose and scope of these Regulations are to prevent, protect against, control and provide a public health response to the international spread of disease in ways that are commensurate with and restricted to public health risks, and which avoid unnecessary interference with international traffic and trade. Primarily, the scope of IHR is to establish a system of early warning (in accordance with Article 6 and 7) with the functioning in each country National IHR Focal Point which is available at any time to communicate with WHO IHR Contact Points and other entities. The tasks of the National IHR Fo- cal Point in Poland which was appointed by the Minister of Health and runs in the Department of Epidemiology, National Institute of Public Health--National Institute of Hygiene from 1 September 2007 are the notification of events that may constitute a public health emergency of international concern occurring in Poland or abroad and the dissemination of this information to the WHO, other National IHR Focal Points or competent authorities responsible for public health. The task of the National IHR Focal Point in Poland is also the dissemination of WHO and ECDC notifications, including recommendation and risk assessment documents. The aim of this work is the review of WHO and ECDC notifications received by National IHR Focal Point in Poland in the period from 2010 to 2015 which were related to emerging infectious diseases not covered by routine vaccination programs or for which

  12. Statistical Earthquake Focal Mechanism Forecasts

    NASA Astrophysics Data System (ADS)

    Kagan, Y. Y.; Jackson, D. D.

    2013-12-01

    The new whole Earth focal mechanism forecast, based on the GCMT catalog, has been created. In the present forecast, the sum of normalized seismic moment tensors within 1000 km radius is calculated and the P- and T-axes for the focal mechanism are evaluated on the basis of the sum. Simultaneously we calculate an average rotation angle between the forecasted mechanism and all the surrounding mechanisms. This average angle shows tectonic complexity of a region and indicates the accuracy of the prediction. The method was originally proposed by Kagan and Jackson (1994, JGR). Recent interest by CSEP and GEM has motivated some improvements, particularly to extend the previous forecast to polar and near-polar regions. The major problem in extending the forecast is the focal mechanism calculation on a spherical surface. In the previous forecast as our average focal mechanism was computed, it was assumed that longitude lines are approximately parallel within 1000 km radius. This is largely accurate in the equatorial and near-equatorial areas. However, when one approaches the 75 degree latitude, the longitude lines are no longer parallel: the bearing (azimuthal) difference at points separated by 1000 km reach about 35 degrees. In most situations a forecast point where we calculate an average focal mechanism is surrounded by earthquakes, so a bias should not be strong due to the difference effect cancellation. But if we move into polar regions, the bearing difference could approach 180 degrees. In a modified program focal mechanisms have been projected on a plane tangent to a sphere at a forecast point. New longitude axes which are parallel in the tangent plane are corrected for the bearing difference. A comparison with the old 75S-75N forecast shows that in equatorial regions the forecasted focal mechanisms are almost the same, and the difference in the forecasted focal mechanisms rotation angle is close to zero. However, though the forecasted focal mechanisms are similar

  13. Continuously variable focal length lens

    DOEpatents

    Adams, Bernhard W; Chollet, Matthieu C

    2013-12-17

    A material preferably in crystal form having a low atomic number such as beryllium (Z=4) provides for the focusing of x-rays in a continuously variable manner. The material is provided with plural spaced curvilinear, optically matched slots and/or recesses through which an x-ray beam is directed. The focal length of the material may be decreased or increased by increasing or decreasing, respectively, the number of slots (or recesses) through which the x-ray beam is directed, while fine tuning of the focal length is accomplished by rotation of the material so as to change the path length of the x-ray beam through the aligned cylindrical slows. X-ray analysis of a fixed point in a solid material may be performed by scanning the energy of the x-ray beam while rotating the material to maintain the beam's focal point at a fixed point in the specimen undergoing analysis.

  14. Focal axis resolver for offset reflector antennas

    NASA Technical Reports Server (NTRS)

    Schmidt, R. F. (Inventor)

    1983-01-01

    Method and apparatus for determining the focal axis of an asymmetrical antenna such as an offset paraboloid reflector whose physical rim is not coincident with the boundary of the electrical aperture but whose focal point is known is provided. A transmitting feed horn array consisting of at least two feed horn elements is positioned asymmetrically on either side of an estimated focal axis which is generally inclined with respect to the boresight axis of the antenna. The feed horn array is aligned with the estimated focal axis so that the phase centers (CP sub 1, CP sub 2) of the two feed horn elements are located on a common line running through the focal point (F) orthogonally with respect to the estimated focal axis.

  15. Simulation and experimental characterization of the point spread function, pixel saturation, and blooming of a mercury cadmium telluride focal plane array.

    PubMed

    Soehnel, Grant; Tanbakuchi, Anthony

    2012-11-20

    A custom IR spot scanning experiment was constructed to project subpixel spots on a mercury cadmium telluride focal plane array (FPA). The hardware consists of an FPA in a liquid nitrogen cooled Dewar, high precision motorized stages, a custom aspheric lens, and a 1.55 and 3.39 μm laser source. By controlling the position and intensity of the spot, characterizations of cross talk, saturation, blooming, and (indirectly) the minority carrier lifetime were performed. In addition, a Monte-Carlo-based charge diffusion model was developed to validate experimental data and make predictions. Results show very good agreement between the model and experimental data. Parameters such as wavelength, reverse bias, and operating temperature were found to have little effect on pixel crosstalk in the absorber layer of the detector. Saturation characterizations show that these FPAs, which do not have antiblooming circuitry, exhibit an increase in cross talk due to blooming at ∼39% beyond the flux required for analog saturation. PMID:23207309

  16. The Teaching of Global Environmental Problems According to the Constructivist Approach: As a Focal Point of the Problem and the Availability of Concept Cartoons

    ERIC Educational Resources Information Center

    Oluk, Sami; Ozalp, Isilay

    2007-01-01

    In this study, with selecting the focusing point of the problem as the availability of cartoons, the teaching of global environmental problems according to the constructivist theory is investigated on the 7th graders in rural areas. This study is restricted with the global warming (G), ozone depletion (O) and the acid rain (A) problems. In the…

  17. Statistical earthquake focal mechanism forecasts

    NASA Astrophysics Data System (ADS)

    Kagan, Yan Y.; Jackson, David D.

    2014-04-01

    Forecasts of the focal mechanisms of future shallow (depth 0-70 km) earthquakes are important for seismic hazard estimates and Coulomb stress, and other models of earthquake occurrence. Here we report on a high-resolution global forecast of earthquake rate density as a function of location, magnitude and focal mechanism. In previous publications we reported forecasts of 0.5° spatial resolution, covering the latitude range from -75° to +75°, based on the Global Central Moment Tensor earthquake catalogue. In the new forecasts we have improved the spatial resolution to 0.1° and the latitude range from pole to pole. Our focal mechanism estimates require distance-weighted combinations of observed focal mechanisms within 1000 km of each gridpoint. Simultaneously, we calculate an average rotation angle between the forecasted mechanism and all the surrounding mechanisms, using the method of Kagan & Jackson proposed in 1994. This average angle reveals the level of tectonic complexity of a region and indicates the accuracy of the prediction. The procedure becomes problematical where longitude lines are not approximately parallel, and where shallow earthquakes are so sparse that an adequate sample spans very large distances. North or south of 75°, the azimuths of points 1000 km away may vary by about 35°. We solved this problem by calculating focal mechanisms on a plane tangent to the Earth's surface at each forecast point, correcting for the rotation of the longitude lines at the locations of earthquakes included in the averaging. The corrections are negligible between -30° and +30° latitude, but outside that band uncorrected rotations can be significantly off. Improved forecasts at 0.5° and 0.1° resolution are posted at http://eq.ess.ucla.edu/kagan/glob_gcmt_index.html.

  18. Beamlet focal plane diagnostic

    SciTech Connect

    Caird, J.A.; Nielsen, N.D.; Patton, H.G.; Seppala, L.G.; Thompson, C.E.; Wegner, P.J.

    1996-12-01

    This paper describes the major optical and mechanical design features of the Beamlet Focal Plane Diagnostic system as well as measurements of the system performance, and typical data obtained to date. We also discuss the NIF requirements on the focal spot that we are interested in measuring, and some of our plans for future work using this system.

  19. Focal neurological deficits

    MedlinePlus

    A focal neurologic deficit is a problem with nerve, spinal cord, or brain function. It affects a specific ... of the back, neck, or head Electromyogram (EMG)/ nerve conduction velocities (NCV) MRI of the back, neck, or head Spinal tap

  20. Partial (focal) seizure

    MedlinePlus

    ... Jacksonian seizure; Seizure - partial (focal); Temporal lobe seizure; Epilepsy - partial seizures ... Abou-Khalil BW, Gallagher MJ, Macdonald RL. Epilepsies. In: Daroff RB, ... 6th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 67. ...

  1. Partial (focal) seizure

    MedlinePlus

    ... Jacksonian seizure; Seizure - partial (focal); Temporal lobe seizure; Epilepsy - partial seizures ... Abou-Khalil BW, Gallagher MJ, Macdonald RL. Epilepsies. In: Daroff ... Practice . 7th ed. Philadelphia, PA: Elsevier; 2016:chap 101. ...

  2. Focal vibration in neurorehabilitation.

    PubMed

    Murillo, N; Valls-Sole, J; Vidal, J; Opisso, E; Medina, J; Kumru, H

    2014-04-01

    During the last decade, many studies have been carried out to understand the effects of focal vibratory stimuli at various levels of the central nervous system and to study pathophysiological mechanisms of neurological disorders as well as the therapeutic effects of focal vibration in neurorehabilitation. This review aimed to describe the effects of focal vibratory stimuli in neurorehabilitation including the neurological diseases or disorders like stroke, spinal cord injury, multiple sclerosis, Parkinson's' disease and dystonia. In conclusion, focal vibration stimulation is well tolerated, effective and easy to use, and it could be used to reduce spasticity, to promote motor activity and motor learning within a functional activity, even in gait training, independent from etiology of neurological pathology. Further studies are needed in the future well-designed trials with bigger sample size to determine the most effective frequency, amplitude and duration of vibration application in the neurorehabilitation. PMID:24842220

  3. Physical Activity Performance of Focal Middle School Students

    ERIC Educational Resources Information Center

    Erfle, Stephen E.; Gelbaugh, Corey M.

    2013-01-01

    Histograms of push-ups and curl-ups from a sample of more than 9,000 students show periodic spikes at five and 10 unit intervals. This article argues that these spikes are related to focal points, a game theoretic concept popularized by Nobel Laureate Thomas Schelling. Being focal on one test makes one more likely to be focal on the other. Focal…

  4. SNAP focal plane

    SciTech Connect

    Lampton, Michael L.; Kim, A.; Akerlof, C.W.; Aldering, G.; Amanullah, R.; Astier, P.; Barrelet, E.; Bebek, C.; Bergstrom, L.; Berkovitz, J.; Bernstein, G.; Bester, M.; Bonissent, A.; Bower, C.; Carithers Jr., W.C.; Commins, E.D.; Day, C.; Deustua, S.E.; DiGennaro,R.; Ealet, A.; Ellis, R.S.; Eriksson, M.; Fruchter, A.; Genat, J.-F.; Goldhaber, G.; Goobar, A.; Groom, D.; Harris, S.E.; Harvey, P.R.; Heetderks, H.D.; Holland, S.E.; Huterer, D.; Karcher, A.; Kolbe, W.; Krieger, B.; Lafever, R.; Lamoureux, J.; Levi, M.E.; Levin, D.S.; Linder,E.V.; Loken, S.C.; Malina, R.; Massey, R.; McKay, T.; McKee, S.P.; Miquel, R.; Mortsell, E.; Mostek, N.; Mufson, S.; Musser, J.; Nugent, P.; Oluseyi, H.; Pain, R.; Palaio, N.; Pankow, D.; Perlmutter, S.; Pratt, R.; Prieto, E.; Refregier, A.; Rhodes, J.; Robinson, K.; Roe, N.; Sholl, M.; Schubnell, M.; Smadja, G.; Smoot, G.; Spadafora, A.; Tarle, G.; Tomasch,A.; von der Lippe, H.; Vincent, R.; Walder, J.-P.; Wang, G.

    2002-07-29

    The proposed SuperNova/Acceleration Probe (SNAP) mission will have a two-meter class telescope delivering diffraction-limited images to an instrumented 0.7 square-degree field sensitive in the visible and near-infrared wavelength regime. We describe the requirements for the instrument suite and the evolution of the focal plane design to the present concept in which all the instrumentation--visible and near-infrared imagers, spectrograph, and star guiders--share one common focal plane.

  5. Focal adhesions in osteoneogenesis

    PubMed Central

    Biggs, M.J.P; Dalby, M.J

    2010-01-01

    As materials technology and the field of tissue engineering advances, the role of cellular adhesive mechanisms, in particular the interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material surface or chemical stimuli in order to help develop next-generation biomaterials. The focus of this review is on recent studies and developments concerning focal adhesion formation in osteoneogenesis, with an emphasis on the influence of synthetic constructs on integrin mediated cellular adhesion and function. PMID:21287830

  6. Sensory-motor integration in focal dystonia.

    PubMed

    Avanzino, Laura; Tinazzi, Michele; Ionta, Silvio; Fiorio, Mirta

    2015-12-01

    Traditional definitions of focal dystonia point to its motor component, mainly affecting planning and execution of voluntary movements. However, focal dystonia is tightly linked also to sensory dysfunction. Accurate motor control requires an optimal processing of afferent inputs from different sensory systems, in particular visual and somatosensory (e.g., touch and proprioception). Several experimental studies indicate that sensory-motor integration - the process through which sensory information is used to plan, execute, and monitor movements - is impaired in focal dystonia. The neural degenerations associated with these alterations affect not only the basal ganglia-thalamic-frontal cortex loop, but also the parietal cortex and cerebellum. The present review outlines the experimental studies describing impaired sensory-motor integration in focal dystonia, establishes their relationship with changes in specific neural mechanisms, and provides new insight towards the implementation of novel intervention protocols. Based on the reviewed state-of-the-art evidence, the theoretical framework summarized in the present article will not only result in a better understanding of the pathophysiology of dystonia, but it will also lead to the development of new rehabilitation strategies. PMID:26164472

  7. Focal liver lesions found incidentally

    PubMed Central

    Algarni, Abdullah A; Alshuhri, Abdullah H; Alonazi, Majed M; Mourad, Moustafa Mabrouk; Bramhall, Simon R

    2016-01-01

    Incidentally found focal liver lesions are a common finding and a reason for referral to hepatobiliary service. They are often discovered in patients with history of liver cirrhosis, colorectal cancer, incidentally during work up for abdominal pain or in a trauma setting. Specific points should considered during history taking such as risk factors of liver cirrhosis; hepatitis, alcohol consumption, substance exposure or use of oral contraceptive pills and metabolic syndromes. Full blood count, liver function test and tumor markers can act as a guide to minimize the differential diagnosis and to categorize the degree of liver disease. Imaging should start with B-mode ultrasound. If available, contrast enhanced ultrasound is a feasible, safe, cost effective option and increases the ability to reach a diagnosis. Contrast enhanced computed tomography should be considered next. It is more accurate in diagnosis and better to study anatomy for possible operation. Contrast enhanced magnetic resonance is the gold standard with the highest sensitivity. If doubt still remains, the options are biopsy or surgical excision. PMID:27028805

  8. Mosaic Focal Plane Development

    NASA Astrophysics Data System (ADS)

    Mason, David L.; Horner, Scott D.; Aamodt, Earl K.

    2002-12-01

    Advances in systems engineering, applied sciences, and manufacturing technologies have enabled the development of large ground based and spaced based astronomical instruments having a large Field of View (FOV) to capture a large portion of the universe in a single image. A larger FOV can be accomplished using light weighted optical elements, improved support structures, and the development of mosaic Focal Plane Assemblies (mFPA). A mFPA designed for astronomy can use multiple Charged Coupled Devices (CCD) mounted onto a single camera baseplate integrated at the instrument plane of focus. Examples of current, or proposed, missions utilizing mFPA technology include FAME, GEST, Kepler, GAIA, LSST, and SNAP. The development of a mFPA mandates tighter control on the design trades, component development, CCD characterization, component integration, and performance verification testing. This paper addresses the capability Lockheed Martin Space Systems Company's (LMSSC) Advanced Technology Center (ATC) has developed to perform CCD characterization, mFPA assembly and alignment, and mFPA system level testing.

  9. Mosaic Focal Plane Development

    NASA Astrophysics Data System (ADS)

    Mason, D.; Horner, S.; Aamodt, E.

    Advances in manufacturing and applied sciences have enabled the development of large ground and spaced based astronomical instruments having a Field of View (FOV) large enough to capture a large portion of the universe in a single image. A large FOV can be accomplished using light weighted optics, improved structures, and the development of mosaic Focal Plane Assemblies (mFPAs). A mFPA comprises multiple Charged Coupled Devices (CCD) mounted onto a single baseplate integrated at the focus plane of the instrument. Examples of current, or proposed, missions utilizing mFPA technology include FAME, GEST, Kepler, GAIA, LSST, and SNAP. The development of a mFPA mandates tight control on the design trades of component development, CCD definition and characterization, component integration, and performance verification testing. This paper addresses the results of the Lockheed Martin Space Systems Company (LMSSC), Advanced Technology Center (ATC) developed mFPA. The design trades and performance characterization are services provided by the LMSSC ATC but not detailed in this paper.

  10. Spitzer Space Telescope: Focal Plane Survey Final Report. Appendix B:; IRAC

    NASA Technical Reports Server (NTRS)

    Bayard, David S.; Kang, Bryan H.; Brugarolas, Paul B.; Boussalis, Dhemetrios

    2004-01-01

    This final report summarizes the results and accuracies of the Spitzer Space Telescope focal plane survey. Accuracies achieved are compared to the focal plane survey calibration requirements put forth in the SIRTF IOC-SV Mission Plan [14] and pre-flight predictions made in [2]. The results of this focal plane survey are presently being used to support in-flight precision pointing, precision incremental offsets, IRS peakup array calibration, and ground pointing reconstruction...

  11. MutComFocal: an integrative approach to identifying recurrent and focal genomic alterations in tumor samples

    PubMed Central

    2013-01-01

    Background Most tumors are the result of accumulated genomic alterations in somatic cells. The emerging spectrum of alterations in tumors is complex and the identification of relevant genes and pathways remains a challenge. Furthermore, key cancer genes are usually found amplified or deleted in chromosomal regions containing many other genes. Point mutations, on the other hand, provide exquisite information about amino acid changes that could be implicated in the oncogenic process. Current large-scale genomic projects provide high throughput genomic data in a large number of well-characterized tumor samples. Methods We define a Bayesian approach designed to identify candidate cancer genes by integrating copy number and point mutation information. Our method exploits the concept that small and recurrent alterations in tumors are more informative in the search for cancer genes. Thus, the algorithm (Mutations with Common Focal Alterations, or MutComFocal) seeks focal copy number alterations and recurrent point mutations within high throughput data from large panels of tumor samples. Results We apply MutComFocal to Diffuse Large B-cell Lymphoma (DLBCL) data from four different high throughput studies, totaling 78 samples assessed for copy number alterations by single nucleotide polymorphism (SNP) array analysis and 65 samples assayed for protein changing point mutations by whole exome/whole transcriptome sequencing. In addition to recapitulating known alterations, MutComFocal identifies ARID1B, ROBO2 and MRS1 as candidate tumor suppressors and KLHL6, IL31 and LRP1 as putative oncogenes in DLBCL. Conclusions We present a Bayesian approach for the identification of candidate cancer genes by integrating data collected in large number of cancer patients, across different studies. When trained on a well-studied dataset, MutComFocal is able to identify most of the reported characterized alterations. The application of MutComFocal to large-scale cancer data provides the

  12. Laser multi-reflection confocal long focal-length measurement

    NASA Astrophysics Data System (ADS)

    Li, Zhigang; Qiu, Lirong; Zhao, Weiqian; Xiao, Yang

    2016-06-01

    We propose a new laser multi-reflection confocal focal-length measurement (MCFM) method to meet the requirements of a high-precision measurement for a long focal-length more than 2 m. It places an optical flat and a reflector behind the test lens for reflecting the measuring beam repeatedly, and then, uses the property that the peak points of confocal response curves precisely corresponds to the convergence points of a multi-reflected measuring beam to exactly identify the positions of the convergence points. Subsequently, it obtains the position variation of the reflector with a different number of reflections by a distance measuring instrument, and thereby achieving the high precise long focal-length measurement. The theoretical analyses and preliminary experimental results indicate that MCFM has a relative standard uncertainty of 0.066% for a test lens with the focal-length of 9.76 m. MCFM can provide a novel approach for the high-precision focal-length measurement.

  13. Precise Measurement of Effective Focal Length

    NASA Technical Reports Server (NTRS)

    Wise, T. D.; Young, J. B.

    1983-01-01

    Computerized instrument measures effective focal lengths to 0.01 percent accuracy. Laser interferometers measure mirror angle and stage coordinate y in instrument for accurate measurment of focal properties of optical systems. Operates under computer control to measure effective focal length, focal surface shape, modulation transfer function, and astigmatism.

  14. Sex prevalence of focal dystonias.

    PubMed Central

    Soland, V L; Bhatia, K P; Marsden, C D

    1996-01-01

    The sex prevalence of idiopathic focal dystonia is reported from a data base review of all patients seen at the National Hospital of Neurology, Queen Square and King's College, London up to 1993. There was a higher prevalence of females to males in all categories of focal dystonia involving the craniocervical region. The female to male ratio for cranial dystonia was 1.92:1 (P < 0.01) and 1.6:1 (P < 0.001) for spasmodic torticollis. On the other hand, twice as many men than women had writer's cramp (M:F = 2.0:1, P < 0.01). At present, there is no clear explanation to account for this differences in the sex prevalence of different types of focal dystonia. PMID:8708656

  15. Focal weakness following herpes zoster.

    PubMed Central

    Cockerell, O C; Ormerod, I E

    1993-01-01

    Three patients presented with focal weakness of an arm which followed segmental herpes zoster affecting the same limb. Neurophysiological investigations suggest that the site of the lesion lay at the root, plexus, or peripheral nerve level. This reflects the various ways in which the virus may affect the peripheral nervous system. PMID:8410022

  16. Wave statistics in a coastal focal zone

    NASA Astrophysics Data System (ADS)

    Janssen, T. T.; Herbers, T. H. C.; Pearman, D. W.; Van Ettinger, E.; Smit, P. B.

    2014-12-01

    Wave-current dynamics in wave focal zones in exposed coastal inlets and river mouths are still poorly understood. This is in part due to lack of observations, which are complicated due to the presence of energetic waves, strong (tidal) currents, dynamic seabed morphology, and often busy ship traffic. Conventional (fixed) instruments, such as buoys and bottom-mounted current or pressure sensors, are difficult to maintain in such areas, and the spatial variability of the wave field is difficult to capture with single point measurements, or even arrays of fixed measurements. In addition to the observational difficulties, the effects of e.g. current shear, wave blocking, statistical inhomogeneity [see Smit & Janssen, 2013, J. Phys. Ocean., 43, pp 1741-1758], and nonlinearity [see Janssen & Herbers, 2009, J. Phys Ocean., 39, pp 1948-1964] on wave statistics are not fully understood, not accounted for in operational stochastic wave models, and - as a consequence - often ignored. In this paper, we consider new observational data of waves approaching the Mouth of the Columbia River undergoing bottom refraction and strong wave-current interaction. The data were collected during the 2013 ONR RIVET experiment using an array of free drifting wave-current buoys. The Lagrangian instruments capture the spatial variability of the wave field in the inlet and, by deploying them in large ensembles, resolve the (inhomogeneous and nonlinear) wave statistics in the focal zone. We discuss the use of free-drifting instruments to measure wave statistics in a coastal wave focal zone, consider the observed effects of wave inhomogeneity, and show that non-Gaussian effects are important and affect extreme wave occurrences in the Mouth of the Columbia River.

  17. Focal length measurement based on the wavefront difference method by a Fizeau interferometer.

    PubMed

    Yang, Zhongming; Gao, Zhishan; Dou, Jiantai; Wang, Xinxing

    2014-09-01

    A method for measuring the focal length of the lens by a Fizeau interferometer is proposed. Based on the Gaussian imaging equation and the longitudinal displacements of the object point and image point, a precise formula for focal length calculation is deduced. The longitudinal displacement of the object points is determined by the wavefront difference method with a subnanometer resolution. An experimental system for focal length measurements is set up to verify the principle. The sources of uncertainty in measurement are discussed. Both the positive and negative lens experimental results indicate that the measurement accuracy is less than 0.16% under normal experimental environment. PMID:25321352

  18. Ultrasound elastographic techniques in focal liver lesions

    PubMed Central

    Conti, Clara Benedetta; Cavalcoli, Federica; Fraquelli, Mirella; Conte, Dario; Massironi, Sara

    2016-01-01

    Elastographic techniques are new ultrasound-based imaging techniques developed to estimate tissue deformability/stiffness. Several ultrasound elastographic approaches have been developed, such as static elastography, transient elastography and acoustic radiation force imaging methods, which include point shear wave and shear wave imaging elastography. The application of these methods in clinical practice aims at estimating the mechanical tissues properties. One of the main settings for the application of these tools has been liver stiffness assessment in chronic liver disease, which has been studied mainly using transient elastography. Another field of application for these techniques is the assessment of focal lesions, detected by ultrasound in organs such as pancreas, prostate, breast, thyroid, lymph nodes. Considering the frequency and importance of the detection of focal liver lesions through routine ultrasound, some studies have also aimed to assess the role that elestography can play in studying the stiffness of different types of liver lesions, in order to predict their nature and thus offer valuable non-invasive methods for the diagnosis of liver masses. PMID:26973405

  19. Small pixel oversampled IR focal plane arrays

    NASA Astrophysics Data System (ADS)

    Caulfield, John; Curzan, Jon; Lewis, Jay; Dhar, Nibir

    2015-06-01

    We report on a new high definition high charge capacity 2.1 Mpixel MWIR Infrared Focal Plane Array. This high definition (HD) FPA utilizes a small 5 um pitch pixel size which is below the Nyquist limit imposed by the optical systems Point Spread Function (PSF). These smaller sub diffraction limited pixels allow spatial oversampling of the image. We show that oversampling IRFPAs enables improved fidelity in imaging including resolution improvements, advanced pixel correlation processing to reduce false alarm rates, improved detection ranges, and an improved ability to track closely spaced objects. Small pixel HD arrays are viewed as the key component enabling lower size, power and weight of the IR Sensor System. Small pixels enables a reduction in the size of the systems components from the smaller detector and ROIC array, the reduced optics focal length and overall lens size, resulting in an overall compactness in the sensor package, cooling and associated electronics. The highly sensitive MWIR small pixel HD FPA has the capability to detect dimmer signals at longer ranges than previously demonstrated.

  20. Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization

    PubMed Central

    Datla, Srinivasa Raju; McGrail, Daniel J.; Vukelic, Sasa; Huff, Lauren P.; Lyle, Alicia N.; Pounkova, Lily; Lee, Minyoung; Seidel-Rogol, Bonnie; Khalil, Mazen K.; Hilenski, Lula L.; Terada, Lance S.; Dawson, Michelle R.; Lassègue, Bernard

    2014-01-01

    Polymerase-δ-interacting protein 2 (Poldip2) interacts with NADPH oxidase 4 (Nox4) and regulates migration; however, the precise underlying mechanisms are unclear. Here, we investigated the role of Poldip2 in focal adhesion turnover, as well as traction force generation and polarization. Poldip2 overexpression (AdPoldip2) in vascular smooth muscle cells (VSMCs) impairs PDGF-induced migration and induces a characteristic phenotype of long cytoplasmic extensions. AdPoldip2 also prevents the decrease in spreading and increased aspect ratio observed in response to PDGF and slightly impairs cell contraction. Moreover, AdPoldip2 blocks focal adhesion dissolution and sustains H2O2 levels in focal adhesions, whereas Poldip2 knockdown (siPoldip2) significantly decreases the number of focal adhesions. RhoA activity is unchanged when focal adhesion dissolution is stimulated in control cells but increases in AdPoldip2-treated cells. Inhibition of RhoA blocks Poldip2-mediated attenuation of focal adhesion dissolution, and overexpression of RhoA or focal adhesion kinase (FAK) reverses the loss of focal adhesions induced by siPoldip2, indicating that RhoA and FAK mediate the effect of Poldip2 on focal adhesions. Nox4 silencing prevents focal adhesion stabilization by AdPoldip2 and induces a phenotype similar to siPoldip2, suggesting a role for Nox4 in Poldip2-induced focal adhesion stability. As a consequence of impaired focal adhesion turnover, PDGF-treated AdPoldip2 cells are unable to reduce and polarize traction forces, a necessary first step in migration. These results implicate Poldip2 in VSMC migration via regulation of focal adhesion turnover and traction force generation in a Nox4/RhoA/FAK-dependent manner. PMID:25063792

  1. Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization.

    PubMed

    Datla, Srinivasa Raju; McGrail, Daniel J; Vukelic, Sasa; Huff, Lauren P; Lyle, Alicia N; Pounkova, Lily; Lee, Minyoung; Seidel-Rogol, Bonnie; Khalil, Mazen K; Hilenski, Lula L; Terada, Lance S; Dawson, Michelle R; Lassègue, Bernard; Griendling, Kathy K

    2014-10-01

    Polymerase-δ-interacting protein 2 (Poldip2) interacts with NADPH oxidase 4 (Nox4) and regulates migration; however, the precise underlying mechanisms are unclear. Here, we investigated the role of Poldip2 in focal adhesion turnover, as well as traction force generation and polarization. Poldip2 overexpression (AdPoldip2) in vascular smooth muscle cells (VSMCs) impairs PDGF-induced migration and induces a characteristic phenotype of long cytoplasmic extensions. AdPoldip2 also prevents the decrease in spreading and increased aspect ratio observed in response to PDGF and slightly impairs cell contraction. Moreover, AdPoldip2 blocks focal adhesion dissolution and sustains H2O2 levels in focal adhesions, whereas Poldip2 knockdown (siPoldip2) significantly decreases the number of focal adhesions. RhoA activity is unchanged when focal adhesion dissolution is stimulated in control cells but increases in AdPoldip2-treated cells. Inhibition of RhoA blocks Poldip2-mediated attenuation of focal adhesion dissolution, and overexpression of RhoA or focal adhesion kinase (FAK) reverses the loss of focal adhesions induced by siPoldip2, indicating that RhoA and FAK mediate the effect of Poldip2 on focal adhesions. Nox4 silencing prevents focal adhesion stabilization by AdPoldip2 and induces a phenotype similar to siPoldip2, suggesting a role for Nox4 in Poldip2-induced focal adhesion stability. As a consequence of impaired focal adhesion turnover, PDGF-treated AdPoldip2 cells are unable to reduce and polarize traction forces, a necessary first step in migration. These results implicate Poldip2 in VSMC migration via regulation of focal adhesion turnover and traction force generation in a Nox4/RhoA/FAK-dependent manner. PMID:25063792

  2. LiteBIRD: Mission Overview and Focal Plane Layout

    NASA Astrophysics Data System (ADS)

    Matsumura, T.; Akiba, Y.; Arnold, K.; Borrill, J.; Chendra, R.; Chinone, Y.; Cukierman, A.; de Haan, T.; Dobbs, M.; Dominjon, A.; Elleflot, T.; Errard, J.; Fujino, T.; Fuke, H.; Goeckner-wald, N.; Halverson, N.; Harvey, P.; Hasegawa, M.; Hattori, K.; Hattori, M.; Hazumi, M.; Hill, C.; Hilton, G.; Holzapfel, W.; Hori, Y.; Hubmayr, J.; Ichiki, K.; Inatani, J.; Inoue, M.; Inoue, Y.; Irie, F.; Irwin, K.; Ishino, H.; Ishitsuka, H.; Jeong, O.; Karatsu, K.; Kashima, S.; Katayama, N.; Kawano, I.; Keating, B.; Kibayashi, A.; Kibe, Y.; Kida, Y.; Kimura, K.; Kimura, N.; Kohri, K.; Komatsu, E.; Kuo, C. L.; Kuromiya, S.; Kusaka, A.; Lee, A.; Linder, E.; Matsuhara, H.; Matsuoka, S.; Matsuura, S.; Mima, S.; Mitsuda, K.; Mizukami, K.; Morii, H.; Morishima, T.; Nagai, M.; Nagasaki, T.; Nagata, R.; Nakajima, M.; Nakamura, S.; Namikawa, T.; Naruse, M.; Natsume, K.; Nishibori, T.; Nishijo, K.; Nishino, H.; Nitta, T.; Noda, A.; Noguchi, T.; Ogawa, H.; Oguri, S.; Ohta, I. S.; Otani, C.; Okada, N.; Okamoto, A.; Okamoto, A.; Okamura, T.; Rebeiz, G.; Richards, P.; Sakai, S.; Sato, N.; Sato, Y.; Segawa, Y.; Sekiguchi, S.; Sekimoto, Y.; Sekine, M.; Seljak, U.; Sherwin, B.; Shinozaki, K.; Shu, S.; Stompor, R.; Sugai, H.; Sugita, H.; Suzuki, T.; Suzuki, A.; Tajima, O.; Takada, S.; Takakura, S.; Takano, K.; Takei, Y.; Tomaru, T.; Tomita, N.; Turin, P.; Utsunomiya, S.; Uzawa, Y.; Wada, T.; Watanabe, H.; Westbrook, B.; Whitehorn, N.; Yamada, Y.; Yamasaki, N.; Yamashita, T.; Yoshida, M.; Yoshida, T.; Yotsumoto, Y.

    2016-08-01

    LiteBIRD is a proposed CMB polarization satellite project to probe the inflationary B-mode signal. The satellite is designed to measure the tensor-to-scalar ratio with a 68 % confidence level uncertainty of σ _r<10^{-3}, including statistical, instrumental systematic, and foreground uncertainties. LiteBIRD will observe the full sky from the second Lagrange point for 3 years. We have a focal plane layout for observing frequency coverage that spans 40-402 GHz to characterize the galactic foregrounds. We have two detector candidates, transition-edge sensor bolometers and microwave kinetic inductance detectors. In both cases, a telecentric focal plane consists of approximately 2× 10^3 superconducting detectors. We will present the mission overview of LiteBIRD, the project status, and the TES focal plane layout.

  3. LiteBIRD: Mission Overview and Focal Plane Layout

    NASA Astrophysics Data System (ADS)

    Matsumura, T.; Akiba, Y.; Arnold, K.; Borrill, J.; Chendra, R.; Chinone, Y.; Cukierman, A.; de Haan, T.; Dobbs, M.; Dominjon, A.; Elleflot, T.; Errard, J.; Fujino, T.; Fuke, H.; Goeckner-wald, N.; Halverson, N.; Harvey, P.; Hasegawa, M.; Hattori, K.; Hattori, M.; Hazumi, M.; Hill, C.; Hilton, G.; Holzapfel, W.; Hori, Y.; Hubmayr, J.; Ichiki, K.; Inatani, J.; Inoue, M.; Inoue, Y.; Irie, F.; Irwin, K.; Ishino, H.; Ishitsuka, H.; Jeong, O.; Karatsu, K.; Kashima, S.; Katayama, N.; Kawano, I.; Keating, B.; Kibayashi, A.; Kibe, Y.; Kida, Y.; Kimura, K.; Kimura, N.; Kohri, K.; Komatsu, E.; Kuo, C. L.; Kuromiya, S.; Kusaka, A.; Lee, A.; Linder, E.; Matsuhara, H.; Matsuoka, S.; Matsuura, S.; Mima, S.; Mitsuda, K.; Mizukami, K.; Morii, H.; Morishima, T.; Nagai, M.; Nagasaki, T.; Nagata, R.; Nakajima, M.; Nakamura, S.; Namikawa, T.; Naruse, M.; Natsume, K.; Nishibori, T.; Nishijo, K.; Nishino, H.; Nitta, T.; Noda, A.; Noguchi, T.; Ogawa, H.; Oguri, S.; Ohta, I. S.; Otani, C.; Okada, N.; Okamoto, A.; Okamoto, A.; Okamura, T.; Rebeiz, G.; Richards, P.; Sakai, S.; Sato, N.; Sato, Y.; Segawa, Y.; Sekiguchi, S.; Sekimoto, Y.; Sekine, M.; Seljak, U.; Sherwin, B.; Shinozaki, K.; Shu, S.; Stompor, R.; Sugai, H.; Sugita, H.; Suzuki, T.; Suzuki, A.; Tajima, O.; Takada, S.; Takakura, S.; Takano, K.; Takei, Y.; Tomaru, T.; Tomita, N.; Turin, P.; Utsunomiya, S.; Uzawa, Y.; Wada, T.; Watanabe, H.; Westbrook, B.; Whitehorn, N.; Yamada, Y.; Yamasaki, N.; Yamashita, T.; Yoshida, M.; Yoshida, T.; Yotsumoto, Y.

    2016-04-01

    LiteBIRD is a proposed CMB polarization satellite project to probe the inflationary B-mode signal. The satellite is designed to measure the tensor-to-scalar ratio with a 68 % confidence level uncertainty of σ _r<10^{-3} , including statistical, instrumental systematic, and foreground uncertainties. LiteBIRD will observe the full sky from the second Lagrange point for 3 years. We have a focal plane layout for observing frequency coverage that spans 40-402 GHz to characterize the galactic foregrounds. We have two detector candidates, transition-edge sensor bolometers and microwave kinetic inductance detectors. In both cases, a telecentric focal plane consists of approximately 2× 10^3 superconducting detectors. We will present the mission overview of LiteBIRD, the project status, and the TES focal plane layout.

  4. Threshold Concepts as Focal Points for Supporting Student Learning

    ERIC Educational Resources Information Center

    Jordan, Katy; Tracy, Frances; Johnstone, Keith

    2011-01-01

    The Plant Sciences Pedagogy Project conducted research into undergraduate teaching and learning in the Department of Plant Sciences at the University of Cambridge and has translated the research findings into interventions to improve support for student learning. A key research objective for the project was to investigate how teachers within the…

  5. Children's capacity to use cultural focal points in coordination problems.

    PubMed

    Goldvicht-Bacon, Efrat; Diesendruck, Gil

    2016-04-01

    Coordination problems require one to act based on expectations about how partners will act. In Experiment 1, 5-year-olds (n=57) had to hide a sticker in the box another child from their, or a different, culture was most likely to search in. Boxes were marked with cues presumed to be known by everybody, cultural members, or the child. Experiment 2 assessed 5-year-olds' (n=57) behavior in a competition scenario. In Experiment 1, children were more likely to hide in the cultural box when playing with a same- than a different-culture partner. In Experiment 2, children's behavior was the opposite. Thus by age 5, children are capable of modulating their actions in coordination problems, according to their partners' presumed knowledge. PMID:26826539

  6. Focal-point conformational analysis of ethanol, propanol, and isopropanol.

    PubMed

    Kahn, Kalju; Bruice, Thomas C

    2005-03-01

    Conformational analysis of three small alcohols--ethanol, propanol, and isopropanol--was carried out by systematically improving the basis set and the level of electron correlation. Correlation energy contributions to conformational energies are strongly basis-set-dependent but accurate energy contributions can be obtained by extrapolation to the basis-set limit. At the basis-set limit, second- and third-order electron correlation effects play a significant role for rotations around the CC-OH, HC-CO, and CC-CO bonds. Specifically, second- and third-order correlation effects strongly stabilize structures in which the hydroxylic hydrogen eclipses with the adjacent carbon; a lesser stabilization is present in structures where the CC-OH moiety is in the gauche form. Fourth-order correlation effects to the CC-OH rotation are small due to a partial cancellation of the singles, doubles, and quadruples contribution by the triples contribution. Electron correlation significantly lowers barriers for methyl-group rotations in ethanol and isopropanol, and in these cases the fourth-order correlation effects are noticeable. The relatively large overall importance of third-order correlation energy contributions raises a concern that the inability to accurately estimate this slowly converging contribution may become a limiting factor when highly accurate conformational energies in larger molecules are sought. PMID:15799474

  7. MRI of Focal Liver Lesions.

    PubMed

    Albiin, Nils

    2012-05-01

    Magnetic resonance imaging, MRI has more advantages than ultrasound, computed tomography, CT, positron emission tomography, PET, or any other imaging modality in diagnosing focal hepatic masses. With a combination of basic T1 and T2 weighted sequences, diffusion weighted imaging, DWI, and hepatobiliary gadolinium contrast agents, that is gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB), most liver lesions can be adequately diagnosed. Benign lesions, as cyst, hemangioma, focal nodular hyperplasia, FNH or adenoma, can be distinguished from malignant lesions. In a non-cirrhotic liver, the most common malignant lesions are metastases which may be hypovascular or hypervascular. In the cirrhotic liver hepatocellular carcinoma, HCC, is of considerable importance. Besides, intrahepatic cholangiocarcinoma and other less common malignancies has to be assessed. In this review, the techniques and typical MRI features are presented as well as the new algorithm issued by American Association for the Study of the Liver Diseases (AASLD). PMID:23049491

  8. Variable focal length deformable mirror

    DOEpatents

    Headley, Daniel; Ramsey, Marc; Schwarz, Jens

    2007-06-12

    A variable focal length deformable mirror has an inner ring and an outer ring that simply support and push axially on opposite sides of a mirror plate. The resulting variable clamping force deforms the mirror plate to provide a parabolic mirror shape. The rings are parallel planar sections of a single paraboloid and can provide an on-axis focus, if the rings are circular, or an off-axis focus, if the rings are elliptical. The focal length of the deformable mirror can be varied by changing the variable clamping force. The deformable mirror can generally be used in any application requiring the focusing or defocusing of light, including with both coherent and incoherent light sources.

  9. [Focal liver lesion, incidental finding].

    PubMed

    Dietrich, C F; Jenssen, C

    2012-10-01

    The differential diagnosis of incidentally found Focal Liver Lesions (FLL) is complex. Screening procedures so far are only defined for patients with liver cirrhosis. Characterization of a FLL begins as soon as it is detected. Taking patients history and thorough clinical examination are essential. An imaging procedure that is used to detect liver masses should also allow the examiner to determine whether the lesion is benign or malignant. Conventional B-mode US and colour Doppler imaging are effective at detecting and characterizing typical liver cysts and calcifications. Laboratory data, computed tomography, magnetic resonance imaging and imaging guided liver biopsy are complementary methods.Contrast Enhanced Ultrasound (CEUS) is a well established diagnostic imaging technique for a variety of indications and applications. One of the most important applications is in the liver where it is frequently a first-line technique for the detection and diagnosis (characterization) of focal liver lesions (FLL). In this setting the accurate differentiation of benign from malignant lesions is critical to ensure the patient undergoes the appropriate therapeutic option. This has been documented in recently published guidelines, in particular in terms of the enhancement patterns of the most common FLL hemangioma, focal nodular hyperplasia hepatocellular adenoma and their differentiation from malignant lesions. In this article the role of CEUS in the characterization of incidentally found FLL is described. PMID:23033169

  10. Persistent Focal Behavior and Physical Activity Performance

    ERIC Educational Resources Information Center

    Erfle, Stephen E.

    2014-01-01

    This article examines the proclivity and performance attributes of focal students across time and activities using data from 9,345 students. Three systematic focal behavior partitions are examined: Across activities, across time, and across activities and time. A student's performance is focal if it ends in 0 or 5 for push-ups and 0 for…

  11. Myofascial trigger point pain.

    PubMed

    Jaeger, Bernadette

    2013-01-01

    Myofascial trigger point pain is an extremely prevalent cause of persistent pain disorders in all parts of the body, not just the head, neck, and face. Features include deep aching pain in any structure, referred from focally tender points in taut bands of skeletal muscle (the trigger points). Diagnosis depends on accurate palpation with 2-4 kg/cm2 of pressure for 10 to 20 seconds over the suspected trigger point to allow the referred pain pattern to develop. In the head and neck region, cervical muscle trigger points (key trigger points) often incite and perpetuate trigger points (satellite trigger points) and referred pain from masticatory muscles. Management requires identification and control of as many perpetuating factors as possible (posture, body mechanics, psychological stress or depression, poor sleep or nutrition). Trigger point therapies such as spray and stretch or trigger point injections are best used as adjunctive therapy. PMID:24864393

  12. Apparatus and method for creating a photonic densely-accumulated ray-point

    NASA Technical Reports Server (NTRS)

    Park, Yeonjoon (Inventor); Choi, Sang H. (Inventor); King, Glen C. (Inventor); Elliott, James R. (Inventor)

    2012-01-01

    An optical apparatus includes an optical diffraction device configured for diffracting a predetermined wavelength of incident light onto adjacent optical focal points, and a photon detector for detecting a spectral characteristic of the predetermined wavelength. One of the optical focal points is a constructive interference point and the other optical focal point is a destructive interference point. The diffraction device, which may be a micro-zone plate (MZP) of micro-ring gratings or an optical lens, generates a constructive ray point using phase-contrasting of the destructive interference point. The ray point is located between adjacent optical focal points. A method of generating a densely-accumulated ray point includes directing incident light onto the optical diffraction device, diffracting the selected wavelength onto the constructive interference focal point and the destructive interference focal point, and generating the densely-accumulated ray point in a narrow region.

  13. SNAP Satellite Focal Plane Development

    SciTech Connect

    Bebek, C.; Akerlof, C.; Aldering, G.; Amanullah, R.; Astier, P.; Baltay, C.; Barrelet, E.; Basa, S.; Bercovitz, J.; Bergstrom, L.; Berstein, G.P.; Bester, M.; Bohlin, R.; Bonissent, A.; Bower, C.; Campbell, M.; Carithers, W.; Commins, E.; Day, C.; Deustua, S.; DiGennaro, R.; Ealet, A.; Ellis, R.; Emmett, W.; Eriksson, M.; Fouchez,D.; Fruchter, A.; Genat, J-F.; Goldhaber, G.; Goobar, A.; Groom, D.; Heetderks, H.; Holland, S.; Huterer, D.; Johnson, W.; Kadel, R.; Karcher,A.; Kim, A.; Kolbe, W.; Lafever, R.; Lamoureaux, J.; Lampton, M.; Lefevre, O.; Levi, M.; Levin, D.; Linder, E.; Loken, S.; Malina, R.; Mazure, A.; McKay, T.; McKee, S.; Miquel, R.; Morgan, N.; Mortsell, E.; Mostek, N.; Mufson, S.; Musser, J.; Roe, N.; Nugent, P.; Oluseyi, H.; Pain, R.; Palaio, N.; Pankow, D.; Perlmutter, S.; Prieto, E.; Rabinowitz,D.; Refregier, A.; Rhodes, J.; Schubnell, M.; Sholl, M.; Smadja, G.; Smith, R.; Smoot, G.; Snyder, J.; Spadafora, A.; Szymkowiak, A.; Tarle,G.; Taylor, K.; Tilquin, A.; Tomasch, A.; Vincent, D.; von der Lippe, H.; Walder, J-P.; Wang, G.

    2003-07-07

    The proposed SuperNova/Acceleration Probe (SNAP) mission will have a two-meter class telescope delivering diffraction-limited images to an instrumented 0.7 square degree field in the visible and near-infrared wavelength regime. The requirements for the instrument suite and the present configuration of the focal plane concept are presented. A two year R&D phase, largely supported by the Department of Energy, is just beginning. We describe the development activities that are taking place to advance our preparedness for mission proposal in the areas of detectors and electronics.

  14. Hemodynamics of focal choroidal excavations.

    PubMed

    Soma, Ryoko; Moriyama, Muka; Ohno-Matsui, Kyoko

    2015-04-01

    The purpose of this study was to investigate the hemodynamics of focal choroidal excavations (FCEs). Four eyes of four patients with a FCE were studied. Indocyanine green angiography (ICGA), laser speckle flowgraphy (LSFG), optical coherence tomography (OCT), and multi-focal electroretinography (mfERG) were performed to investigate the choroidal hemodynamics and the morphological and functional changes. The mean depth of the FCE determined by OCT was 222.5 ± 49.5 μm with a range of 164-272 μm. In one case, subretinal fluid was observed in the excavation, and in three cases, subretinal fluid was not observed. ICGA showed hypofluorescence, and laser flowgraphy (LSFG) showed decreased choroidal blood flow at the excavation in all cases. Three cases were symptomatic, and the amplitudes of the mfERGs were reduced. FCEs cause a decrease of choroidal blood flow. In three of four cases, the mfERGs were depressed over the FCEs leading to symptoms. PMID:25626897

  15. Rewritable photochromic focal plane masks

    NASA Astrophysics Data System (ADS)

    Molinari, Emilio; Bertarelli, Chiara; Bianco, Andrea; Bortoletto, Fabio; Conconi, Paolo; Crimi, Giuseppe; Gallazzi, Maria C.; Giro, Enrico; Lucotti, Andrea; Pernechele, Claudio; Zerbi, Filippo M.; Zerbi, Giuseppe

    2003-02-01

    The application of organic photochromic materials in astronomy is opening new possibilities which we are investigating in order to design innovative devices for future instrumentation. The photochromic property of transparent/opaque transition (although in a limited wavelength range) and the changes in intrinsic refractive index have led our studies to application in astronomic spectrographs, both as focal plane mask (for MOS application) and as dispersive elements (volume phase holographic gratings, VPHG), respectively. In both cases the possibility to write and erase devices with suitable irradiation has revealed a new perspective for non-disposable and fully customizable items for spectroscopy. Pursuing this goal we have synthesized a series of novel photochromic materials belonging to the diarylethenes. They fulfill the requirements of thermal stability and fatigue resistance necessary to build functional devices. Prototypes of high contrast focal plane mask working in the H-alpha spectral region have been manufactured and characterized both in laboratory and with the AFOSC camera at Asiago telescope (1.8 m). A custom writing robot (ARATRO) which, taking imaging frames and with the aid of interactive mask design software and ad hoc control electronics, is able to write MOS masks, has been constructed. The design of the MOS masks allow the fitting in the AFOSC slit wheel. The overall set-up is ready for the sky tests.

  16. Point Relay Scanner Utilizing Ellipsoidal Mirrors

    NASA Technical Reports Server (NTRS)

    Manhart, Paul K. (Inventor); Pagano, Robert J. (Inventor)

    1997-01-01

    A scanning system uses a polygonal mirror assembly with each facet of the polygon having an ellipsoidal mirror located thereon. One focal point of each ellipsoidal mirror is located at a common point on the axis of rotation of the polygonal mirror assembly. As the mirror assembly rotates. a second focal point of the ellipsoidal mirrors traces out a scan line. The scanner can be utilized for scanned output display of information or for scanning information to be detected.

  17. Quantum-Well Infrared Photodetector (QWIP) Focal Plane Assembly

    NASA Technical Reports Server (NTRS)

    Jhabvala, Murzy; Jhabvala, Christine A.; Ewin, Audrey J.; Hess, Larry A.; Hartmann, Thomas M.; La, Anh T.

    2012-01-01

    A paper describes the Thermal Infrared Sensor (TIRS), a QWIP-based instrument intended to supplement the Operational Land Imager (OLI) for the Landsat Data Continuity Mission (LDCM). The TIRS instrument is a far-infrared imager operating in the pushbroom mode with two IR channels: 10.8 and 12 microns. The focal plane will contain three 640x512 QWIP arrays mounted on a silicon substrate. The silicon substrate is a custom-fabricated carrier board with a single layer of aluminum interconnects. The general fabrication process starts with a 4-in. (approx.10-cm) diameter silicon wafer. The wafer is oxidized, a single substrate contact is etched, and aluminum is deposited, patterned, and alloyed. This technology development is aimed at incorporating three large-format infrared detecting arrays based on GaAs QWIP technology onto a common focal plane with precision alignment of all three arrays. This focal plane must survive the rigors of flight qualification and operate at a temperature of 43 K (-230 C) for five years while orbiting the Earth. The challenges presented include ensuring thermal compatibility among all the components, designing and building a compact, somewhat modular system and ensuring alignment to very tight levels. The multi-array focal plane integrated onto a single silicon substrate is a new application of both QWIP array development and silicon wafer scale integration. The Invar-based assembly has been tested to ensure thermal reliability.

  18. Tie-In Orbits for the Focal Plane Stability Test

    NASA Astrophysics Data System (ADS)

    Abramowicz-Reed, Linda

    1991-07-01

    This proposal is part of the TTSC request entitled, "Distortion Calibration in FGS 1 and FGS 2, FGS-to-FGS Alignment Calibration". This portion is listed separately due to the time critical nature of one of the orbits. OFAD in FGS 3 which will be performed in December 1992 together with the Mini OFAD's in FGS's 1 and 2 which will be performed in January 1993 will provide a new set of FGS calibration parameters. One of the objectives of the STScI Focal Plane Stability test is to monitor changes to these parameters by repeatedly observing targets in the cluster M35. Since the cluster is near the ecliptic, only two vehicle orientations are needed, the "fall" and the "spring" pointings (see attached pickles plots). Since the Mini OFAD targets are not necessarily the same targets used in the Focal Plane Stability Test, tie in orbits using the Focal Plane Stability targets are needed shortly before and after the Mini OFAD activities. In addition, the Focal Plane Stability Test may not be

  19. Focal axis resolver for offset reflector antennas

    NASA Technical Reports Server (NTRS)

    Schmidt, R. F.

    1980-01-01

    Described are electrical means for determining the focal axis of an offset reflector antenna whose physical rim is not coincident with the boundary of the electrical aperture. Even and odd sensing functions are employed in the focal region, leading to both amplitude and phase criteria for resolving a focal axis generally inclined with respect to the system axis. The analytical aspects of the problem are discussed, and an example related to a 4-meter Large-Antenna Multiple-Frequency Microwave Radiometer (LAMMR) is included. The technique is useful for focal axis determination in mathematical simulations and in the physical world.

  20. Digital scanner infrared focal plane technology

    NASA Astrophysics Data System (ADS)

    Ortiz, M. A.; Malone, N. R.; Harris, M.; Shin, J.; Byers, S.; Price, D.; Vampola, J.

    2011-09-01

    Advancements in finer geometry and technology advancements in circuit design now allow placement of digital architecture on cryogenic focal planes while using less power than heritage analog designs. These advances in technology reduce the size, weight, and power of modern focal planes. In addition, the interface to the focal plane is significantly simplified and is more immune to Electromagnetic Interference (EMI). The cost of the customer's instrument after integration with the digital scanning Focal Plane Array (FPA) has been significantly reduced by placing digital architecture such as Analog to digital convertors and Low Voltage Differential Signaling (LVDS) Inputs and Outputs (I/O) on the Read Out Integrated Circuit (ROIC).

  1. Neurocysticercosis presenting as focal hydrocephalus

    PubMed Central

    Malik, Azharuddin Mohammed; Shamim, Md Dilawez; Ahmad, Mehtab; Abdali, Nasar

    2014-01-01

    A 40-year-old man presented with a 2-month history of headache, nausea and vomiting, with generalised seizures for the past 15 days. On examination he had bilateral papilloedema, visual acuity was 6/6 in both eyes but perimetry showed right homonymous inferior quadrantanopia. His MRI showed numerous small cystic lesions with eccentric nodules, diffusely distributed in bilateral cerebral and cerebellar hemispheres. There was also focal hydrocephalus involving occipital and temporal horns of the left lateral ventricle leading to its selective dilation. Stool examination showed ova of Taenia solium. He was treated with albendazole, prednisone and sustained release sodium valproate for 1 month. His headache resolved and he is free of seizures. Repeat perimetry at 1 month also showed resolution of visual field defect. PMID:24962486

  2. Optimal focal-plane restoration

    NASA Technical Reports Server (NTRS)

    Reichenbach, Stephen E.; Park, Stephen K.

    1989-01-01

    Image restoration can be implemented efficiently by calculating the convolution of the digital image and a small kernel during image acquisition. Processing the image in the focal-plane in this way requires less computation than traditional Fourier-transform-based techniques such as the Wiener filter and constrained least-squares filter. Here, the values of the convolution kernel that yield the restoration with minimum expected mean-square error are determined using a frequency analysis of the end-to-end imaging system. This development accounts for constraints on the size and shape of the spatial kernel and all the components of the imaging system. Simulation results indicate the technique is effective and efficient.

  3. Angle dependent focal spot size of a conical X-ray target.

    PubMed

    Raza, Hamid Saeed; Kim, Hyun Jin; Kim, Hyun Nam; Cho, Sung Oh

    2015-02-01

    Misaligned phantoms may severely affect the focal spot calculations. A method is proposed to determine the geometry of the X-ray target and the position of the image radiograph around the X-ray target to get a relatively smaller focal spot size. Results reveal that the focal spot size is not always isotropic around the target but it decreases as the point of observation shifts radially away from the center line of the conical X-ray target. This research will help in producing high quality X-ray images in multi-directions by properly aligning the phantoms and the radiograph tallies. PMID:25474766

  4. GABAergic networks jump-start focal seizures.

    PubMed

    de Curtis, Marco; Avoli, Massimo

    2016-05-01

    Abnormally enhanced glutamatergic excitation is commonly believed to mark the onset of a focal seizure. This notion, however, is not supported by firm evidence, and it will be challenged here. A general reduction of unit firing has been indeed observed in association with low-voltage fast activity at the onset of seizures recorded during presurgical intracranial monitoring in patients with focal, drug-resistant epilepsies. Moreover, focal seizures in animal models start with increased γ-aminobutyric acid (GABA)ergic interneuronal activity that silences principal cells. In vitro studies have shown that synchronous activation of GABAA receptors occurs at seizure onset and causes sizeable elevations in extracellular potassium, thus facilitating neuronal recruitment and seizure progression. A paradoxical involvement of GABAergic networks is required for the initiation of focal seizures characterized by low-voltage fast activity, which represents the most common seizure-onset pattern in focal epilepsies. PMID:27061793

  5. SIRTF Focal Plane Survey: A Pre-flight Error Analysis

    NASA Technical Reports Server (NTRS)

    Bayard, David S.; Brugarolas, Paul B.; Boussalis, Dhemetrios; Kang, Bryan H.

    2003-01-01

    This report contains a pre-flight error analysis of the calibration accuracies expected from implementing the currently planned SIRTF focal plane survey strategy. The main purpose of this study is to verify that the planned strategy will meet focal plane survey calibration requirements (as put forth in the SIRTF IOC-SV Mission Plan [4]), and to quantify the actual accuracies expected. The error analysis was performed by running the Instrument Pointing Frame (IPF) Kalman filter on a complete set of simulated IOC-SV survey data, and studying the resulting propagated covariances. The main conclusion of this study is that the all focal plane calibration requirements can be met with the currently planned survey strategy. The associated margins range from 3 to 95 percent, and tend to be smallest for frames having a 0.14" requirement, and largest for frames having a more generous 0.28" (or larger) requirement. The smallest margin of 3 percent is associated with the IRAC 3.6 and 5.8 micron array centers (frames 068 and 069), and the largest margin of 95 percent is associated with the MIPS 160 micron array center (frame 087). For pointing purposes, the most critical calibrations are for the IRS Peakup sweet spots and short wavelength slit centers (frames 019, 023, 052, 028, 034). Results show that these frames are meeting their 0.14" requirements with an expected accuracy of approximately 0.1", which corresponds to a 28 percent margin.

  6. Causes and pathogenesis of focal segmental glomerulosclerosis

    PubMed Central

    Fogo, Agnes B.

    2016-01-01

    Focal segmental glomerulosclerosis (FSGS) describes both a common lesion in progressive kidney disease, and a disease characterized by marked proteinuria and podocyte injury. The initial injuries vary widely. Monogenetic forms of FSGS are largely due to alterations in structural genes of the podocyte, many of which result in early onset of disease. Genetic risk alleles in apolipoprotein L1 are especially prevalent in African Americans, and are linked not only to adult-onset FSGS but also to progression of some other kidney diseases. The recurrence of FSGS in some transplant recipients whose end-stage renal disease was caused by FSGS points to circulating factors in disease pathogenesis, which remain incompletely understood. In addition, infection, drug use, and secondary maladaptive responses after loss of nephrons from any cause may also cause FSGS. Varying phenotypes of the sclerosis are also manifest, with varying prognosis. The so-called tip lesion has the best prognosis, whereas the collapsing type of FSGS has the worst prognosis. New insights into glomerular cell injury response and repair may pave the way for possible therapeutic strategies. PMID:25447132

  7. Report on SEQUAL/FOCAL

    NASA Astrophysics Data System (ADS)

    Katz, E. J.; Philander, S. G. H.; Richardson, P. L.

    In Eos (April 6, 1982), United States plans for a program to study the dynamic response of the equatorial Atlantic to seasonally varying surface winds were described. Now, 6 years later, we report on progress toward our goal “to describe accurately, and to model correctly” the changes in the currents and density field of the upper equatorial Atlantic Ocean during a 2-year period. A major effort toward this goal was the field phase of SEQUAL (Seasonal Response of the Equatorial Atlantic) and the closely coordinated French program FOCAL (Français Océan et Climat dans l'Atlantique Equatorial).Between February 1983 and September 1984 changes in the surface winds and in oceanic conditions in the equatorial Atlantic were monitored continuously with a variety of instruments. Figure 1 shows key deployments and sections. The resulting data include six current meter moorings, 15 inverted echo sounders and island tide gauges, 57 near-surface drifters, and 18 French and five U.S. cruises that made 1200 hydrographic stations and 800 current profiles. All these data, as well as nearly 10,000 expendable bathythermographs (XBTs) (from the cruises, from air-dropped expendable bathythermograph (AXBT) programs, and from repeated ship of opportunity lines run between 1980 and 1985) were combined and documented by George Heimerdinger, of the National Oceanographic Data Center, and are available from NODC on request.

  8. Early vision and focal attention

    NASA Astrophysics Data System (ADS)

    Julesz, Bela

    1991-07-01

    At the thirty-year anniversary of the introduction of the technique of computer-generated random-dot stereograms and random-dot cinematograms into psychology, the impact of the technique on brain research and on the study of artificial intelligence is reviewed. The main finding-that stereoscopic depth perception (stereopsis), motion perception, and preattentive texture discrimination are basically bottom-up processes, which occur without the help of the top-down processes of cognition and semantic memory-greatly simplifies the study of these processes of early vision and permits the linking of human perception with monkey neurophysiology. Particularly interesting are the unexpected findings that stereopsis (assumed to be local) is a global process, while texture discrimination (assumed to be a global process, governed by statistics) is local, based on some conspicuous local features (textons). It is shown that the top-down process of "shape (depth) from shading" does not affect stereopsis, and some of the models of machine vision are evaluated. The asymmetry effect of human texture discrimination is discussed, together with recent nonlinear spatial filter models and a novel extension of the texton theory that can cope with the asymmetry problem. This didactic review attempts to introduce the physicist to the field of psychobiology and its problems-including metascientific problems of brain research, problems of scientific creativity, the state of artificial intelligence research (including connectionist neural networks) aimed at modeling brain activity, and the fundamental role of focal attention in mental events.

  9. Unilateral Isolated Proximal Femoral Focal Deficiency

    PubMed Central

    Doğer, Emek; Köpük, Şule Y.; Çakıroğlu, Yiğit; Çakır, Özgür; Yücesoy, Gülseren

    2013-01-01

    Objective. To discuss a patient with a prenatal diagnosis of unilateral isolated femoral focal deficiency. Case. Antenatal diagnosis of unilateral isolated femoral focal deficiency was made at 20 weeks of gestation. The length of left femur was shorter than the right, and fetal femur length was below the fifth percentile. Proximal femoral focal deficiency was diagnosed. After delivery, the diagnosis was confirmed with skeletal radiographs and magnetic resonance imaging. In prenatal ultrasonographic examination, the early recognition and exclusion of skeletal dysplasias is important; moreover, treatment plans should be initiated, and valuable information should be provided to the family. PMID:23984135

  10. Monte Carlo simulation of the effect of focal spot size on contrast-detail detectability.

    PubMed

    Poletti, John; McLean, Donald

    2012-03-01

    A contrast-detail experiment was simulated using Monte Carlo methods, to test the hypothesis that quantum limitations lead to an optimum minimum focal spot size below which no further improvement in image quality may be obtained. The simulation included a variable X-ray tube focal spot size, patient equivalent water phantom, X-ray couch, automatic exposure control, anti-scatter grid and indirect digital radiography detector. A number of simplifications were necessary in order to limit the calculation time to 8 days per image. Four images were produced for each focal spot size and these were scored by eight experienced observers. The contrast-detail curves were found to improve monotonically as focal spot size was reduced, with the best images produced by a point source. This contradicts the hypothesis of quantum limitation of focal spot size. We conclude that further work is required on the optimization of focal spot size. To assist with this, a new definition of system detective quantum efficiency is suggested, that includes the focal spot modulation transfer function, but does not include scattered radiation from the patient. PMID:22143903

  11. Effect of controlled offset of focal position in cavitation-enhanced high-intensity focused ultrasound treatment

    NASA Astrophysics Data System (ADS)

    Goto, Kota; Takagi, Ryo; Miyashita, Takuya; Jimbo, Hayato; Yoshizawa, Shin; Umemura, Shin-ichiro

    2015-07-01

    High-intensity focused ultrasound (HIFU) is a noninvasive treatment for tumors such as cancer. In this method, ultrasound is generated outside the body and focused to the target tissue. Therefore, physical and mental stresses on the patient are minimal. A drawback of the HIFU treatment is a long treatment time for a large tumor due to the small therapeutic volume by a single exposure. Enhancing the heating effect of ultrasound by cavitation bubbles may solve this problem. However, this is rather difficult because cavitation clouds tend to be formed backward from the focal point while ultrasonic intensity for heating is centered at the focal point. In this study, the focal points of the trigger pulses to generate cavitation were offset forward from those of the heating ultrasound to match the cavitation clouds with the heating patterns. Results suggest that the controlled offset of focal points makes the thermal coagulation more predictable.

  12. Exhaustive linearization for robust camera pose and focal length estimation.

    PubMed

    Penate-Sanchez, Adrian; Andrade-Cetto, Juan; Moreno-Noguer, Francesc

    2013-10-01

    We propose a novel approach for the estimation of the pose and focal length of a camera from a set of 3D-to-2D point correspondences. Our method compares favorably to competing approaches in that it is both more accurate than existing closed form solutions, as well as faster and also more accurate than iterative ones. Our approach is inspired on the EPnP algorithm, a recent O(n) solution for the calibrated case. Yet we show that considering the focal length as an additional unknown renders the linearization and relinearization techniques of the original approach no longer valid, especially with large amounts of noise. We present new methodologies to circumvent this limitation termed exhaustive linearization and exhaustive relinearization which perform a systematic exploration of the solution space in closed form. The method is evaluated on both real and synthetic data, and our results show that besides producing precise focal length estimation, the retrieved camera pose is almost as accurate as the one computed using the EPnP, which assumes a calibrated camera. PMID:23969384

  13. Experimental characterization, evaluation, and diagnosis of advanced hybrid infrared focal plane array electro-optical performance

    NASA Astrophysics Data System (ADS)

    Lomheim, Terrence S.; Schumann, Lee W.; Kohn, Stanley E.

    1998-07-01

    High performance scanning time-delay-and-integration and staring hybrid focal plane devices with very large formats, small pixel sizes, formidable frame and line rates, on-chip digital programmability, and high dynamic ranges, are being developed for a myriad of defense, civil, and commercial applications that span the spectral range from shortwave infrared (SWIR) to longwave infrared (LWIR). An essential part in the development of such new advanced hybrid infrared focal planes is empirical validation of their electro-optical (EO) performance. Many high-reliability, high-performance applications demand stringent and near flawless EO performance over a wide variety of operating conditions and environments. Verification of focal plane performance compliance over this wide range of parametric conditions requires the development and use of accurate, flexible, and statistically complete test methods and associated equipment. In this paper we review typical focal plane requirements, the ensuing measurement requirements (quantity, accuracy, repeatability, etc.), test methodologies, test equipment requirements, electronics and computer-based data acquisition requirements, statistical data analysis and display requirements, and associated issues. We also discuss special test requirements for verifying the performance of panchromatic thermal and multispectral imaging focal planes where characterization of dynamic modulation transfer function (MTF), and point-image response and optical overload is generally required. We briefly overview focal plane radiation testing. We conclude with a discussion of the technical challenges of characterizing future advanced hybrid focal plane testing where it is anticipated that analog-to- digital conversion will be included directly on focal plane devices, thus creating the scenario of 'photons-in-to-bits- out' within the focal plane itself.

  14. Sighting optics including an optical element having a first focal length and a second focal length

    DOEpatents

    Crandall, David Lynn

    2011-08-01

    One embodiment of sighting optics according to the teachings provided herein may include a front sight and a rear sight positioned in spaced-apart relation. The rear sight includes an optical element having a first focal length and a second focal length. The first focal length is selected so that it is about equal to a distance separating the optical element and the front sight and the second focal length is selected so that it is about equal to a target distance. The optical element thus brings into simultaneous focus, for a user, images of the front sight and the target.

  15. Focal Mechanism determination of local M

    NASA Astrophysics Data System (ADS)

    Vales, Dina; Custório, Susana; Carrilho, Fernando

    2015-04-01

    We determine the focal mechanisms of local small (ML<3.9) earthquakes that occurred between 2013 and 2014 in mainland Portugal. These low magnitude events were recorded by several stations that provide first-motion polarity solutions. However, only few stations are located near the epicenter and record a waveform with a signal-to-noise ratio (SNR) high enough to allow full waveform modelling. To overcome this limitation, we used a new approach called cyclic scanning of the polarity solutions (CSPS) (Fojtíková and Zahradnik, 2014), which performs a joint inversion of full waveform and first motion polarities to retrieve the focal mechanism. This methodology has the advantage of yielding reliable focal mechanism solutions, even when high SNR waveforms are available from only a few near field stations (or in the limiting case, only with one single station). To apply the CSPS method one needs to: i) run the the FOCal MEChanism (FOCMEC) code (Snoke, 2003) to obtain a suite of the DC solutions corresponding to the first motion polarities, and then ii) perform the waveform modelling in order to decrease the uncertainty. The ISOLated Asperities (ISOLA) software (Sokos and Zahradník, 2008, 2013) is used in this second step. We applied this method to weak events recorded by a network of 30 broadband seismic stations that transmit data in real-time to Instituto Português do Mar e da Atmosfera (IPMA), the institution responsible for seismic monitoring in Portugal. We interpret the obtained fault plane solutions in light of active faults and regional tectonics, and in comparison with focal mechanisms previously inferred for events in the region. The focal mechanisms obtained for small earthquakes allow us to significantly expand the database of available focal mechanisms in mainland Portugal, contributing to the understanding of active deformation in the region.

  16. NMDA receptor binding in focal epilepsies

    PubMed Central

    McGinnity, C J; Koepp, M J; Hammers, A; Riaño Barros, D A; Pressler, R M; Luthra, S; Jones, P A; Trigg, W; Micallef, C; Symms, M R; Brooks, D J; Duncan, J S

    2015-01-01

    Objective To demonstrate altered N-methyl-d-aspartate (NMDA) receptor availability in patients with focal epilepsies using positron emission tomography (PET) and [18F]GE-179, a ligand that selectively binds to the open NMDA receptor ion channel, which is thought to be overactive in epilepsy. Methods Eleven patients (median age 33 years, 6 males) with known frequent interictal epileptiform discharges had an [18F]GE-179 PET scan, in a cross-sectional study. MRI showed a focal lesion but discordant EEG changes in two, was non-localising with multifocal EEG abnormalities in two, and was normal in the remaining seven patients who all had multifocal EEG changes. Individual patient [18F]GE-179 volume-of-distribution (VT) images were compared between individual patients and a group of 10 healthy controls (47 years, 7 males) using Statistical Parametric Mapping. Results Individual analyses revealed a single cluster of focal VT increase in four patients; one with a single and one with multifocal MRI lesions, and two with normal MRIs. Post hoc analysis revealed that, relative to controls, patients not taking antidepressants had globally increased [18F]GE-179 VT (+28%; p<0.002), and the three patients taking an antidepressant drug had globally reduced [18F]GE-179 VT (−29%; p<0.002). There were no focal abnormalities common to the epilepsy group. Conclusions In patients with focal epilepsies, we detected primarily global increases of [18F]GE-179 VT consistent with increased NMDA channel activation, but reduced availability in those taking antidepressant drugs, consistent with a possible mode of action of this class of drugs. [18F]GE-179 PET showed focal accentuations of NMDA binding in 4 out of 11 patients, with difficult to localise and treat focal epilepsy. PMID:25991402

  17. Focal dermal hypoplasia (Goltz syndrome).

    PubMed

    Riyaz, Najeeba; Riyaz, A; Chandran, Rajesh; Rakesh, S V

    2005-01-01

    A 7-year-old girl born of non-consanguineous marriage was evaluated for facial dysmorphism. She had multiple skeletal anomalies like hypoplasia of the right mandible, narrow nasal bridge with broad tip and unilateral notching of the right ala nasi, concomitant squint and low set ears. She also had generalized hypopigmented, atrophic linear macules, multiple papillomas, fat herniations, umbilical hernia, hypoplastic nails, cicatricial alopecia, mild mental retardation, 'lobster-claw' hand and osteopathia striata of long bones, pointing to a diagnosis of Goltz syndrome. The unusual features noted were absence of the left first rib and aortic regurgitation. PMID:16394441

  18. Laser multi-reflection differential confocal long focal-length measurement.

    PubMed

    Li, Zhigang; Qiu, Lirong; Zhao, Weiqian; Zhao, Qi

    2016-06-20

    We propose a new laser multi-reflection differential confocal focal-length measurement (LDCFM) method to meet the requirements of high-precision measurements of long focal lengths. An optical flat and a reflector are placed behind a test lens for reflecting the measuring beam repeatedly. Then, LDCFM uses the property that the null points of differential confocal response curves precisely correspond to the convergence points of the multi-reflected measuring beam to exactly determine the positions of the convergence points accurately. Subsequently, the position variation of the reflector is measured with different reflection times by using a distance-measuring instrument, and thereby the long focal length is measured precisely. Theoretical analyses and preliminary experimental results indicate that the LDCFM method has a relative expanded standard uncertainty (k=2) of 0.04% for the test lens with a focal length of 9.76 m. The LDCFM method can provide a novel approach for high-precision focal-length measurements. PMID:27409117

  19. Focal Plane Metrology for the LSST Camera

    SciTech Connect

    A Rasmussen, Andrew P.; Hale, Layton; Kim, Peter; Lee, Eric; Perl, Martin; Schindler, Rafe; Takacs, Peter; Thurston, Timothy; /SLAC

    2007-01-10

    Meeting the science goals for the Large Synoptic Survey Telescope (LSST) translates into a demanding set of imaging performance requirements for the optical system over a wide (3.5{sup o}) field of view. In turn, meeting those imaging requirements necessitates maintaining precise control of the focal plane surface (10 {micro}m P-V) over the entire field of view (640 mm diameter) at the operating temperature (T {approx} -100 C) and over the operational elevation angle range. We briefly describe the hierarchical design approach for the LSST Camera focal plane and the baseline design for assembling the flat focal plane at room temperature. Preliminary results of gravity load and thermal distortion calculations are provided, and early metrological verification of candidate materials under cold thermal conditions are presented. A detailed, generalized method for stitching together sparse metrology data originating from differential, non-contact metrological data acquisition spanning multiple (non-continuous) sensor surfaces making up the focal plane, is described and demonstrated. Finally, we describe some in situ alignment verification alternatives, some of which may be integrated into the camera's focal plane.

  20. Kalman Filter for Calibrating a Telescope Focal Plane

    NASA Technical Reports Server (NTRS)

    Kang, Bryan; Bayard, David

    2006-01-01

    The instrument-pointing frame (IPF) Kalman filter, and an algorithm that implements this filter, have been devised for calibrating the focal plane of a telescope. As used here, calibration signifies, more specifically, a combination of measurements and calculations directed toward ensuring accuracy in aiming the telescope and determining the locations of objects imaged in various arrays of photodetectors in instruments located on the focal plane. The IPF Kalman filter was originally intended for application to a spaceborne infrared astronomical telescope, but can also be applied to other spaceborne and ground-based telescopes. In the traditional approach to calibration of a telescope, (1) one team of experts concentrates on estimating parameters (e.g., pointing alignments and gyroscope drifts) that are classified as being of primarily an engineering nature, (2) another team of experts concentrates on estimating calibration parameters (e.g., plate scales and optical distortions) that are classified as being primarily of a scientific nature, and (3) the two teams repeatedly exchange data in an iterative process in which each team refines its estimates with the help of the data provided by the other team. This iterative process is inefficient and uneconomical because it is time-consuming and entails the maintenance of two survey teams and the development of computer programs specific to the requirements of each team. Moreover, theoretical analysis reveals that the engineering/ science iterative approach is not optimal in that it does not yield the best estimates of focal-plane parameters and, depending on the application, may not even enable convergence toward a set of estimates.

  1. HIGH PERFORMANCE PIAA CORONAGRAPHY WITH COMPLEX AMPLITUDE FOCAL PLANE MASKS

    SciTech Connect

    Guyon, Olivier; Martinache, Frantz; Belikov, Ruslan; Soummer, Remi

    2010-10-15

    We describe a coronagraph approach where the performance of a Phase-Induced Amplitude Apodization (PIAA) coronagraph is improved by using a partially transmissive phase-shifting focal plane mask and a Lyot stop. This approach combines the low inner working angle offered by phase mask coronagraphy, the full throughput and uncompromized angular resolution of the PIAA approach, and the design flexibility of Apodized Pupil Lyot Coronagraph. A PIAA complex mask coronagraph (PIAACMC) is fully described by the focal plane mask size, or, equivalently, its complex transmission which ranges from 0 (opaque) to -1 (phase shifting). For all values of the transmission, the PIAACMC theoretically offers full on-axis extinction and 100% throughput at large angular separations. With a pure phase focal plane mask (complex transmission = -1), the PIAACMC offers 50% throughput at 0.64 {lambda}/D while providing total extinction of an on-axis point source. This performance is very close to the 'fundamental performance limit' of coronagraphy derived from first principles. For very high contrast level, imaging performance with PIAACMC is in practice limited by the angular size of the on-axis target (usually a star). We show that this fundamental limitation must be taken into account when choosing the optimal value of the focal plane mask size in the PIAACMC design. We show that the PIAACMC enables visible imaging of Jupiter-like planets at {approx}1.2 {lambda}/D from the host star, and can therefore offer almost three times more targets than a PIAA coronagraph optimized for this type of observation. We find that for visible imaging of Earth-like planets, the PIAACMC gain over a PIAA is probably much smaller, as coronagraphic performance is then strongly constrained by stellar angular size. For observations at 'low' contrast (below {approx} 10{sup 8}), the PIAACMC offers significant performance enhancement over PIAA. This is especially relevant for ground-based high contrast imaging

  2. Solid-state curved focal plane arrays

    NASA Technical Reports Server (NTRS)

    Nikzad, Shouleh (Inventor); Hoenk, Michael (Inventor); Jones, Todd (Inventor)

    2010-01-01

    The present invention relates to curved focal plane arrays. More specifically, the present invention relates to a system and method for making solid-state curved focal plane arrays from standard and high-purity devices that may be matched to a given optical system. There are two ways to make a curved focal plane arrays starting with the fully fabricated device. One way, is to thin the device and conform it to a curvature. A second way, is to back-illuminate a thick device without making a thinned membrane. The thick device is a special class of devices; for example devices fabricated with high purity silicon. One surface of the device (the non VLSI fabricated surface, also referred to as the back surface) can be polished to form a curved surface.

  3. Measuring microfocus focal spots using digital radiography

    SciTech Connect

    Fry, David A

    2009-01-01

    Measurement of microfocus spot size can be important for several reasons: (1) Quality assurance during manufacture of microfocus tubes; (2) Tracking performance and stability of microfocus tubes; (3) Determining magnification (especially important for digital radiography where the native spatial resolution of the digital system is not adequate for the application); (4) Knowledge of unsharpness from the focal spot alone. The European Standard EN 12543-5 is based on a simple geometrical method of calculating focal spot size from unsharpness of high magnification film radiographs. When determining microfocus focal spot dimensions using unsharpness measurements both signal-to-noise (SNR) and magnification can be important. There is a maximum accuracy that is a function of SNR and therefore an optimal magnification. Greater than optimal magnification can be used but it will not increase accuracy.

  4. Actinic Granuloma with Focal Segmental Glomerulosclerosis

    PubMed Central

    Phasukthaworn, Ruedee; Chanprapaph, Kumutnart; Vachiramon, Vasanop

    2016-01-01

    Actinic granuloma is an uncommon granulomatous disease, characterized by annular erythematous plaque with central clearing predominately located on sun-damaged skin. The pathogenesis is not well understood, ultraviolet radiation is recognized as precipitating factor. We report a case of a 52-year-old woman who presented with asymptomatic annular erythematous plaques on the forehead and both cheeks persisting for 2 years. The clinical presentation and histopathologic findings support the diagnosis of actinic granuloma. During that period of time, she also developed focal segmental glomerulosclerosis. The association between actinic granuloma and focal segmental glomerulosclerosis needs to be clarified by further studies. PMID:27293392

  5. Hybrid Extrinsic Silicon Focal Plane Architecture

    NASA Astrophysics Data System (ADS)

    Pommerrenig, D. H.; Meinhardt, T.; Lowe, J.

    1981-02-01

    Large-area focal planes require mechanical assembly techniques which must be compatible with optical alignment, minimum deadspace, and cryogenic requirements in order to achieve optimum performance. Hybrid extrinsic silicon has been found particularly suitable for such an application. It will be shown that by choosing a large-area extrinsic silicon detector array which is hybrid-mated to a multiplicity of multiplexers a very cost-effective and high-density focal plane module can be assembled. Other advantages of this approach are inherent optical alignment and excellent performance.

  6. Ambroxol-induced focal epileptic seizure.

    PubMed

    Lapenta, Leonardo; Morano, Alessandra; Fattouch, Jinane; Casciato, Sara; Fanella, Martina; Giallonardo, Anna Teresa; Di Bonaventura, Carlo

    2014-01-01

    It is well known that in epileptic patients some compounds and different drugs used for the treatment of comorbidities can facilitate or provoke seizures, this evidence regarding a wide spectrum of pharmacological categories. The potential facilitating factors usually include direct toxic effects or pharmacological interactions of either active ingredients or excipients. We report the case of a patient with drug-resistant epilepsy who experienced focal epileptic seizures, easily and constantly reproducible, after each administration of a cough syrup. This is, to our knowledge, the first electroencephalogram-documented case of focal epileptic seizures induced by cough syrup containing ambroxol as active ingredient. PMID:24824664

  7. [Liver ultrasound: focal lesions and diffuse diseases].

    PubMed

    Segura Grau, A; Valero López, I; Díaz Rodríguez, N; Segura Cabral, J M

    2016-01-01

    Liver ultrasound is frequently used as a first-line technique for the detection and characterization of the most common liver lesions, especially those incidentally found focal liver lesions, and for monitoring of chronic liver diseases. Ultrasound is not only used in the Bmode, but also with Doppler and, more recently, contrast-enhanced ultrasound. It is mainly used in the diagnosis of diffuse liver diseases, such as steatosis or cirrhosis. This article presents a practical approach for diagnosis workup, in which the different characteristics of the main focal liver lesions and diffuse liver diseases are reviewed. PMID:25523277

  8. Complex source description of focal regions.

    PubMed

    Monzon, Cesar; Forester, Donald W; Moore, Peter

    2006-04-01

    Closed-form solutions of the two-dimensional homogeneous wave equation are presented that provide focal-region descriptions corresponding to a converging bundle of rays. The solutions do have evanescent wave content and can be described as a source-sink pair or particle-antiparticle pair, collocated in complex space, with the complex location being critical in the determination of beam shape and focal region size. The wave solutions are not plagued by singularities, have a finite energy, and have a limitation on how small the focal size can get, with a penalty for limiting small spot sizes in the form of impractically high associated reactive energy. The electric-field-defined spot-size limiting value is 0.35lambda x 0.35lambda, which is about 38% of the Poynting-vector-defined minimum spot size (0.8lambda x 0.4lambda) and corresponds to a condition related to the maximum possible beam angle. A multiple set of solutions is introduced, and the elementary solutions are used to produce new solutions via superposition, resulting in fields with chiral character or with increased depth of focus. We do not claim generality, as the size of focal regions exhibited by the closed-form solutions has a lower bound and hence is not able to account for Pendry's "ideal lens" scenario. PMID:16604758

  9. Focal Dermal Hypoplasia: A Rare Case Report

    PubMed Central

    Srinivas, Sahana M; Hiremagalore, Ravi

    2015-01-01

    Focal dermal hypoplasia (Goltz syndrome) is a rare genetic multisystem disorder primarily involving the skin, skeletal system, eyes, and face. We report the case of an eight-month-old female child who presented with multiple hypopigmented atrophic macules along the lines of blaschko, skeletal anomalies, umbilical hernia, developmental delay, hypoplastic nails, syndactyly, and lobster claw deformity characteristic of Goltz syndrome. PMID:25657436

  10. MTI Focal Plane Assembly Design and Performance

    SciTech Connect

    Ballard, M.; Rienstra, J.L.

    1999-06-17

    The focal plane assembly for the Multispectral Thermal Imager (MTI) consists of sensor chip assemblies, optical filters, and a vacuum enclosure. Sensor chip assemblies, composed of linear detector arrays and readout integrated circuits, provide spatial resolution in the cross-track direction for the pushbroom imager. Optical filters define 15 spectral bands in a range from 0.45 {micro}m to 10.7 {micro}m. All the detector arrays are mounted on a single focal plane and are designed to operate at 75 K. Three pairs of sensor chip assemblies (SCAs) are required to provide cross-track coverage in all 15 spectral bands. Each pair of SCAs includes detector arrays made from silicon, iridium antimonide, and mercury cadmium telluride. Read out integrated circuits multiplex the signals from the detectors to 18 separate video channels. Optical filter assemblies defining the spectral bands are mounted over the linear detector arrays. Each filter assembly consists of several filter strips bonded together side-by-side. The MTI focal plane assembly has been integrated with the rest of the payload and has undergone detailed testing and calibration. This paper includes representative test data for the various spectral bands and the overall performance of the focal plane assembly.

  11. Optical interconnections to focal plane arrays

    SciTech Connect

    Rienstra, J.L.; Hinckley, M.K.

    2000-11-01

    The authors have successfully demonstrated an optical data interconnection from the output of a focal plane array to the downstream data acquisition electronics. The demonstrated approach included a continuous wave laser beam directed at a multiple quantum well reflectance modulator connected to the focal plane array analog output. The output waveform from the optical interconnect was observed on an oscilloscope to be a replica of the input signal. They fed the output of the optical data link to the same data acquisition system used to characterize focal plane array performance. Measurements of the signal to noise ratio at the input and output of the optical interconnection showed that the signal to noise ratio was reduced by a factor of 10 or more. Analysis of the noise and link gain showed that the primary contributors to the additional noise were laser intensity noise and photodetector receiver noise. Subsequent efforts should be able to reduce these noise sources considerably and should result in substantially improved signal to noise performance. They also observed significant photocurrent generation in the reflectance modulator that imposes a current load on the focal plane array output amplifier. This current loading is an issue with the demonstrated approach because it tends to negate the power saving feature of the reflectance modulator interconnection concept.

  12. Focal dermal hypoplasia: a rare case report.

    PubMed

    Srinivas, Sahana M; Hiremagalore, Ravi

    2015-01-01

    Focal dermal hypoplasia (Goltz syndrome) is a rare genetic multisystem disorder primarily involving the skin, skeletal system, eyes, and face. We report the case of an eight-month-old female child who presented with multiple hypopigmented atrophic macules along the lines of blaschko, skeletal anomalies, umbilical hernia, developmental delay, hypoplastic nails, syndactyly, and lobster claw deformity characteristic of Goltz syndrome. PMID:25657436

  13. Dual band QWIP focal plane array

    NASA Technical Reports Server (NTRS)

    Gunapala, Sarath D. (Inventor); Choi, Kwong Kit (Inventor); Bandara, Sumith V. (Inventor)

    2005-01-01

    A quantum well infrared photodetector (QWIP) that provides two-color image sensing. Two different quantum wells are configured to absorb two different wavelengths. The QWIPs are arrayed in a focal plane array (FPA). The two-color QWIPs are selected for readout by selective electrical contact with the two different QWIPs or by the use of two different wavelength sensitive gratings.

  14. Towards Dualband Megapixel QWIP Focal Plane Arrays

    NASA Technical Reports Server (NTRS)

    Gunapala, S. D.; Bandara, S. V.; Liu, J. K.; Mumolo, J. M.; Hill, C. J.; Rafol, S. B.; Salazar, D.; Woolaway, J.; LeVan, P. D.; Tidrow, M. Z.

    2006-01-01

    Mid-wavelength infrared (MWIR) and long-wavelength infrared (LWIR) 1024 x 1024 pixel quantum well infrared photodetector (QWIP) focal planes have been demonstrated with excellent imaging performance. The MWIR QWIP detector array has demonstrated a noise equivalent differential temperature (NEDT) of 17 mK at a 95 K operating temperature with f/2.5 optics at 300 K background and the LWIR detector array has demonstrated a NEDT of 13 mK at a 70 K operating temperature with the same optical and background conditions as the MWIR detector array after the subtraction of system noise. Both MWIR and LWIR focal planes have shown background limited performance (BLIP) at 90 K and 70 K operating temperatures respectively, with similar optical and background conditions. In addition, we have demonstrated MWIR and LWIR pixel co-registered simultaneously readable dualband QWIP focal plane arrays. In this paper, we will discuss the performance in terms of quantum efficiency, NEDT, uniformity, operability, and modulation transfer functions of the 1024 x 1024 pixel arrays and the progress of dualband QWIP focal plane array development work.

  15. Large Format Multicolor QWIP Focal Plane Arrays

    NASA Technical Reports Server (NTRS)

    Soibel, A.; Gunapala, S. D.; Bandara, S. V.; Liu, J. K.; Mumolo, J. M.; Ting, D. Z.; Hill, C. J.; Nguyen, J.

    2009-01-01

    Mid-wave infrared (MWIR) and long-wave infrared (LWIR) multicolor focal plane array (FPA) cameras are essential for many DoD and NASA applications including Earth and planetary remote sensing. In this paper we summarize our recent development of large format multicolor QWIP FPA that cover MWIR and LWIR bands.

  16. Focal lengths of Venus Monitoring Camera from limb locations

    NASA Astrophysics Data System (ADS)

    Limaye, Sanjay S.; Markiewicz, W. J.; Krauss, R.; Ignatiev, N.; Roatsch, T.; Matz, K. D.

    2015-08-01

    The Venus Monitoring Camera (VMC) carried by European Space Agency's Venus Express orbiter (Svedhem et al., 2007) consists of four optical units, each with a separate filter casting an image on a single CCD (Markiewicz et al., 2007a, 2007b). The desire to capture as much of the planet in a single frame during the spacecraft's 24 h, 0.84 eccentricity orbit led to optics with 18° field of view. Analysis of Venus images obtained by the VMC indicated that the computed limb radius and altitude of haze layers were somewhat inconsistent with prior knowledge and expectations. Possible causes include errors in the knowledge of image geometry, misalignment of the optic axis from the pointing direction, and optical distortion. These were explored and eliminated, leaving only deviations from the ground and pre-solar damage estimate of the focal length lengths as the most likely reason. We use the location of planet's limb to estimate the focal length of each camera using images of the planet when the orbiter was more than 20,000 km from planet center. The method relies on the limb radius to be constant at least over a small range of solar zenith angles. We were able to achieve better estimates for the focal lengths for all four cameras and also estimate small offsets to the boresight alignment. An outcome of this analysis is the finding that the slant unit optical depth varies more rapidly with solar zenith angle in the afternoon as compared to morning, with lowest values at local noon. A variation of this level is also observed with latitude. Both are indicative of the presence of overlying haze above the clouds, and the morning afternoon asymmetry suggests different photochemical processes in destruction and production of the haze.

  17. Signal processing and compensation electronics for junction field-effect transistor /JFET/ focal plane arrays

    NASA Astrophysics Data System (ADS)

    Wittig, K. R.

    1982-06-01

    A signal processing system has been designed and constructed for a pyroelectric infrared area detector which uses a matrix-addressable JFET array for readout and for on-focal plane preamplification. The system compensates for all offset and gain nonuniformities in and after the array. Both compensations are performed in real time at standard television rates, so that changes in the response characteristics of the array are automatically corrected for. Two-point compensation is achieved without the need for two separate temperature references. The focal plane circuitry used to read out the array, the offset and gain compensation algorithms, the architecture of the signal processor, and the system hardware are described.

  18. Focal-Plane Array Receiver Systems for Space Communications

    NASA Astrophysics Data System (ADS)

    Britcliffe, M.; Hoppe, D.; Vilnrotter, V.

    2007-08-01

    Typical ground antennas intended for use in space communications require large apertures operating at high frequencies. The challenge involved with these applications is achieving the required antenna performance in terms of antenna aperture efficiency and pointing accuracy. The utilization of a focal-plane array in place of a standard single-mode feed minimizes these problems. This article discusses the key elements required to implement a focal-plane array on a large high-frequency antenna. The example of the NASA Deep Space Network 70-m antennas operating at 32 GHz has been chosen to illustrate these advantages. The design of a suitable feed and low-noise cryogenically cooled amplifier and the required signal-processing techniques are described. It is shown that adaptive least mean-square algorithms can be applied to the output of the array elements, in order to obtain the optimum combining weights in real time, even in the presence of dynamic interference (nearby spacecraft in the array's field of view or planetary radiation). This adaptive optimization capability maximizes the combined output signal-to-noise ratio in real time, ensuring maximum data throughput in the communications link when operating in the presence of receiver noise and external interference generally present during planetary encounters.

  19. Focal therapy for prostate cancer: current status and future perspectives.

    PubMed

    Miano, R; Asimakopoulos, A; Da Silva, R; Bove, P; Jones, S; De La Rosette, J; Kim, F

    2015-09-01

    Focal therapy is a relatively new and extremely attractive option of treatment for prostate cancer. It has been described as the "middle approach" between active surveillance and radical treatment, aiming to destroy the tumor itself or the region containing the tumor in order to preserve surrounding non-cancerous tissue. The goal is to maintain disease control at acceptable levels, while preserving erectile, urinary, and rectal function. While a lot of technologies have been described for delivering targeted therapy to the prostate, such as cryoablation, high intensity focused ultrasound, photodynamic therapy, irreversible electroporation and laser, the key point is the patient selection. Recent advances in mpMRI and the introduction of new biopsy techniques that use MR images as a guidance, have significantly improved localization of the tumor lesions and the detection rate, evolving prostate biopsy toward targeted rather than systematic biopsies. The future challenge to clinicians is to precisely risk-stratify patients to differentiate between those who would profit from focal treatment and who would not. Forthcoming research efforts should pursue to identify molecular, genetic, and imaging characteristics that distinguish aggressive prostate tumors from indolent lesions. PMID:26013953

  20. Focal length and radius of curvature measurement using wavefront difference method

    NASA Astrophysics Data System (ADS)

    Yang, Zhongming; Gao, Zhishan; Wang, Shuai; Cheng, Jinlong; Yuan, Qun

    2015-10-01

    A method for measuring the focal length of the lens and the radius of curvature of the spherical surface using wavefront difference method is proposed. Based on Fizeau interferometer, an experimental system for focal length measurements is set up to verify the principle. Based on the point diffraction interferometer, an experimental system for radius of curvature measurements is proposed to verify the proposed method. With the focal length testing system, both the positive and negative lens experimental results indicate that the measurement accuracy is less than 0.16%under normal experimental environment. With the radius of curvature testing system, the radius of curvature of spherical mirrors and the surface figure can be measured in a higher precision simultaneously. The experimental results indicate that the measurement accuracy is in the order of 10-4 .

  1. Enhanced focal-resolution of dipole sources using aeroacoustic time-reversal in a wind tunnel

    NASA Astrophysics Data System (ADS)

    Mimani, A.; Moreau, D. J.; Prime, Z.; Doolan, C. J.

    2016-05-01

    This paper presents the first application of the Point-Time-Reversal-Sponge-Layer (PTRSL) damping technique to enhance the focal-resolution of experimental flow-induced dipole sources obtained using the Time-Reversal (TR) source localization method. Experiments were conducted in an Anechoic Wind Tunnel for the case of a full-span cylinder located in a low Mach number cross-flow. The far-field acoustic pressure sampled using two line arrays of microphones located above and below the cylinder exhibited a dominant Aeolian tone. The aeroacoustic TR simulations were implemented using the time-reversed signals whereby the source map revealed the lift-dipole nature at the Aeolian tone frequency. A PTRSL (centred at the predicted dipole location) was shown to reduce the size of dipole focal spots to 7/20th of a wavelength as compared to one wavelength without its use, thereby dramatically enhancing the focal-resolution of the TR technique.

  2. Crosstalk in the measurement of focal brain activation by near-infrared topography

    NASA Astrophysics Data System (ADS)

    Okui, N.; Okada, E.

    2005-08-01

    Crosstalk between oxy- and deoxy-haemoglobin observed in near-infrared topography is investigated. The light propagation in an adult head model is predicted by Monte Carlo simulation to obtain the change in intensity detected with source-detector pairs on the scalp caused by a focal absorption change in the brain. The topographic images of changes in oxy- and deoxy-haemoglobin are obtained from the changes in intensity detected with source-detector pairs on the scalp. The crosstalk depends on the relative position of the focal absorption change to source-detector pairs. The crosstalk is minimised when the focal absorption change is located below a measurement point that is the midpoint between a source and a detector. Appropriate selection of wavelength pair is effective to reduce the crosstalk in the topographic image.

  3. Teal Amber Visible Focal Plane Technology

    NASA Astrophysics Data System (ADS)

    Johnson, Charles R.; Burczewski, Ron

    1981-12-01

    Deep-space surveillance missions have imposed severe demands on existing technology and simulated the search for new, advanced technology developments to provide higher performance. Defense Advanced Research Projects Agency (DARPA) sponsored Teal Amber as a visible charge-coupled device (CCD) and associated focal plane signal processing technology development and demonstration program. This paper describes this large-scale, staring-array-sensor concept. The current state of art in the resulting visibled CCD imagers is specified, along with the focal plane signal processor implementation in low power-weight-volume large-scale integrated (LSI) circuitry. Performance requirements and analytic predictions are compared to demonstration system results from an electro-optical test site in White Sands, New Mexico.

  4. Dynamic reactive astrocytes after focal ischemia

    PubMed Central

    Ding, Shinghua

    2014-01-01

    Astrocytes are specialized and most numerous glial cell type in the central nervous system and play important roles in physiology. Astrocytes are also critically involved in many neural disorders including focal ischemic stroke, a leading cause of brain injury and human death. One of the prominent pathological features of focal ischemic stroke is reactive astrogliosis and glial scar formation associated with morphological changes and proliferation. This review paper discusses the recent advances in spatial and temporal dynamics of morphology and proliferation of reactive astrocytes after ischemic stroke based on results from experimental animal studies. As reactive astrocytes exhibit stem cell-like properties, knowledge of dynamics of reactive astrocytes and glial scar formation will provide important insights for astrocyte-based cell therapy in stroke. PMID:25657720

  5. Myxoid adrenal adenoma with focal pseudoglandular pattern.

    PubMed

    De Padua, Michelle; Rajagopal, V

    2008-05-01

    Adrenal cortical tumors with myxoid change are rare tumors. To our knowledge, only 22 cases have been described so far in literature, which include 13 carcinomas and 9 adenomas. A pseudoglandular pattern has been described in 9 of these tumors. We report a case of a myxoid adenoma of the left adrenal gland in a 67-year-old woman, with a focal pseudoglandular pattern involving about 20% of the studied tumor. Rest of the tumor was composed of anastomosing cords of tumor cells. Abundant myxoid stroma was present, which stained positively with alcian blue and was weakly focally positive with periodic acid Schiff. Immunophenotype was consistent with an adrenal tumor, i.e., positive for vimentin, inhibin, and melan A. Cytokeratin AE1/AE3 and chromogranin were negative. MIB-1 index was < 0.1%. PMID:18579979

  6. Chest pain in focal musculoskeletal disorders.

    PubMed

    Stochkendahl, Mette Jensen; Christensen, Henrik Wulff

    2010-03-01

    The musculoskeletal system is a recognized source of chest pain. However, despite the apparently benign origin, patients with musculoskeletal chest pain remain under-diagnosed, untreated, and potentially continuously disabled in terms of anxiety, depression, and activities of daily living. Several overlapping conditions and syndromes of focal disorders, including Tietze syndrome, costochondritis, chest wall syndrome, muscle tenderness, slipping rib, cervical angina, and segmental dysfunction of the cervical and thoracic spine, have been reported to cause pain. For most of these syndromes, evidence arises mainly from case stories and empiric knowledge. For segmental dysfunction, clinical features of musculoskeletal chest pain have been characterized in a few clinical trials. This article summarizes the most commonly encountered syndromes of focal musculoskeletal disorders in clinical practice. PMID:20380955

  7. Focal tracer uptake in the jaw.

    PubMed

    El-Zahry, Mai R; Sinzinger, Helmut

    2014-01-01

    Focal tracer uptake in the jaw during conventional bone scintigraphy is a quite frequent finding usually due to dental disease and seldom to other diseases including malignant disease. Methylene diphosphonate-technetium-99m ((99m)Tc-MDP) 3-phase bone scan is considered the most sensitive imaging method for the detection of jaw osteonecrosis at an early stage. This finding can also but seldom be seen in patients undergoing palliative radionuclide treatment for bone metastases. In conclusion, focal jaw lesions are usually benign and of dental origin. In a small percentage of cancer patients of about 4.3%, jaw lesions as diagnosed among 347 cases of various carcinomas may be due to malignancy. Unfortunately, the number of studies is small, most of them are retrospective and few show biopsy results. PMID:25397621

  8. Focal region fields of distorted reflectors

    NASA Technical Reports Server (NTRS)

    Buris, N. E.; Kauffman, J. F.

    1988-01-01

    The problem of the focal region fields scattered by an arbitrary surface reflector under uniform plane wave illumination is solved. The physical optics (PO) approximation is used to calculate the current induced on the reflector. The surface of the reflector is described by a number of triangular domain-wise 5th degree bivariate polynomials. A 2-dimensional Gaussian quadrature is employed to numerically evaluate the integral expressions of the scattered fields. No Freshnel or Fraunhofer zone approximations are made. The relation of the focal fields problem to surface compensation techniques and other applications are mentioned. Several examples of distorted parabolic reflectors are presented. The computer code developed is included, together with instructions on its usage.

  9. Extensive Focal Epithelial Hyperplasia: A Case Report

    PubMed Central

    Mansouri, Zahra; Bakhtiari, Sedigheh; Noormohamadi, Robab

    2015-01-01

    Focal epithelial hyperplasia (FEH) or Heck’s disease is a rare viral infection of the oral mucosa caused by human papilloma virus especially subtypes 13 or 32. The frequency of this disease varies widely from one geographic region and ethnic groups to another. This paper reports an Iranian case of extensive focal epithelial hyperplasia. A 35-year-old man with FEH is described, in whom the lesions had persisted for more than 25 years. The lesion was diagnosed according to both clinical and histopathological features. Dental practitioner should be aware of these types of lesions and histopathological examination together and a careful clinical observation should be carried out for a definitive diagnosis. PMID:26351501

  10. Focal colors are universal after all

    PubMed Central

    Regier, Terry; Kay, Paul; Cook, Richard S.

    2005-01-01

    It is widely held that named color categories in the world's languages are organized around universal focal colors and that these focal colors tend to be chosen as the best examples of color terms across languages. However, this notion has been supported primarily by data from languages of industrialized societies. In contrast, recent research on a language from a nonindustrialized society has called this idea into question. We examine color-naming data from languages of 110 nonindustrialized societies and show that (i) best-example choices for color terms in these languages cluster near the prototypes for English white, black, red, green, yellow, and blue, and (ii) best-example choices cluster more tightly across languages than do the centers of category extensions, suggesting that universal best examples (foci) may be the source of universal tendencies in color naming. PMID:15923257

  11. Focal adhesions, stress fibers and mechanical tension

    PubMed Central

    Burridge, Keith; Guilluy, Christophe

    2016-01-01

    Stress fibers and focal adhesions are complex protein arrays that produce, transmit and sense mechanical tension. Evidence accumulated over many years led to the conclusion that mechanical tension generated within stress fibers contributes to the assembly of both stress fibers themselves and their associated focal adhesions. However, several lines of evidence have recently been presented against this model. Here we discuss the evidence for and against the role of mechanical tension in driving the assembly of these structures. We also consider how their assembly is influenced by the rigidity of the substratum to which cells are adhering. Finally, we discuss the recently identified connections between stress fibers and the nucleus, and the roles that these may play, both in cell migration and regulating nuclear function. PMID:26519907

  12. Advanced high-performance 320x240 VOx microbolometer uncooled IR focal plane

    NASA Astrophysics Data System (ADS)

    Howard, Philip E.; Clarke, John E.; Parrish, William J.; Woolaway, James T., II

    1999-07-01

    This paper describes Boeing's next-generation 320 X 320 uncooled IR focal plane product. The basic objectives have ben to at least double focal plane performance, improve focal pane operating stability, and significantly enhance the control interface between the focal pane and the camera. All of these basic objectives have been achieved. Focal plane temporal NETD equals 0.028 degrees C has been demonstrated at a frame rate of 60 Hz on the first lot of UFPAs produced, as well as a worst-case spatial NETD < 0.016 degrees C measured over 10 degrees C temperature calibration range. Operating stability improvement has been successfully demonstrated. The design has validated a 'smart sensor' UFPA/camera control interface that provides externally programmability of on-chip signal gain, on-chip pixel offset compensation, on-chip detector bias regulation, precision on-chip temperature measurement, and a 16 test- point Built In Test function. Based on Lot-1 test results, the next lot, which is now in wafer processing, is expected to achieve NETD < 0.02 degrees C at a 60 Hz frame rate. With an improved microbolometer Thermal Isolation Structure, currently in development at Boeing, NETD < 0.010 degrees C can be demonstrated before the end of this year.

  13. Infrared fiber optic focal plane dispersers

    NASA Technical Reports Server (NTRS)

    Goebel, J. H.

    1981-01-01

    Far infrared transmissive fiber optics as a component in the design of integrated far infrared focal plane array utilization is discussed. A tightly packed bundle of fibers is placed at the focal plane, where an array of infrared detectors would normally reside, and then fanned out in two or three dimensions to individual detectors. Subsequently, the detectors are multiplexed by cryogenic electronics for relay of the data. A second possible application is frequency up-conversion (v sub 1 + v sub 2 = v sub 3), which takes advantage of the nonlinear optical index of refraction of certain infrared transmissive materials in fiber form. Again, a fiber bundle is utilized as above, but now a laser of frequency v sub 1 is mixed with the incoming radiation of frequency v sub 1 within the nonlinear fiber material. The sum, v sub 2 is then detected by near infrared or visible detectors which are more sensitive than those available at v sub 2. Due to the geometrical size limitations of detectors such as photomultipliers, the focal plane dispersal technique is advantageous for imaging up-conversion.

  14. Focal plane scanner with reciprocating spatial window

    NASA Technical Reports Server (NTRS)

    Mao, Chengye (Inventor)

    2000-01-01

    A focal plane scanner having a front objective lens, a spatial window for selectively passing a portion of the image therethrough, and a CCD array for receiving the passed portion of the image. All embodiments have a common feature whereby the spatial window and CCD array are mounted for simultaneous relative reciprocating movement with respect to the front objective lens, and the spatial window is mounted within the focal plane of the front objective. In a first embodiment, the spatial window is a slit and the CCD array is one-dimensional, and successive rows of the image in the focal plane of the front objective lens are passed to the CCD array by an image relay lens interposed between the slit and the CCD array. In a second embodiment, the spatial window is a slit, the CCD array is two-dimensional, and a prism-grating-prism optical spectrometer is interposed between the slit and the CCD array so as to cause the scanned row to be split into a plurality of spectral separations onto the CCD array. In a third embodiment, the CCD array is two-dimensional and the spatial window is a rectangular linear variable filter (LVF) window, so as to cause the scanned rows impinging on the LVF to be bandpass filtered into spectral components onto the CCD array through an image relay lens interposed between the LVF and the CCD array.

  15. [Focal therapy for prostate cancer: German version].

    PubMed

    Kasivisvanathan, V; Shah, T T; Donaldson, I; Kanthabalan, A; Moore, C M; Emberton, M; Ahmed, H U

    2015-02-01

    Focal therapy is a treatment strategy for men with localized prostate cancer that may serve as an alternative option to radical therapy. A number of minimally invasive ablative technologies are available to deliver treatment, and the energies most commonly used include high-intensity focused ultrasound and cryotherapy. The benefit of a tissue-preserving approach is the limitation of damage to key structures such as the neurovascular bundles, external urinary sphincter, rectal mucosa and bladder neck. This in turn minimizes side effects typically associated with radical therapies whilst also aiming to maintain oncological control. Over 30 single-centre studies of focal therapy have been published to date reporting excellent continence rates, good potency rates and acceptable short-term oncological outcomes. However, there are a number of controversial aspects associated with focal therapy including the index lesion hypothesis, patient selection criteria, assessment of treatment effect and the lack of medium- and long-term oncological outcomes. In the process of the adoption of new technology, there is a limited window of opportunity to provide this evidence in well-designed prospective trials. Men should be allowed to benefit from the potential advantages of this novel treatment whilst under close surveillance. An English version of this article is available under dx.doi.org/10.1007/s00120-014-3734-7. PMID:25690574

  16. Mechanism of Focal Adhesion Kinase Mechanosensing.

    PubMed

    Zhou, Jing; Aponte-Santamaría, Camilo; Sturm, Sebastian; Bullerjahn, Jakob Tómas; Bronowska, Agnieszka; Gräter, Frauke

    2015-11-01

    Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile forces, propagating from the membrane through the PIP2 binding site of the FERM domain and from the cytoskeleton-anchored FAT domain, activate FAK by unlocking its central phosphorylation site (Tyr576/577) from the autoinhibitory FERM domain. Varying loading rates, pulling directions, and membrane PIP2 concentrations corroborate the specific opening of the FERM-kinase domain interface, due to its remarkably lower mechanical stability compared to the individual alpha-helical domains and the PIP2-FERM link. Analyzing downstream signaling networks provides further evidence for an intrinsic mechano-signaling role of FAK in broadcasting force signals through Ras to the nucleus. This distinguishes FAK from hitherto identified focal adhesion mechano-responsive molecules, allowing a new interpretation of cell stretching experiments. PMID:26544178

  17. The Focal Surface of EUSO Telescope

    NASA Technical Reports Server (NTRS)

    Shimizu, H. M.; Kawasaki, Y.; Takizawa, Y.; Sakaki, N.; Teshima, M.; Ebisuzaki, T.; Takahashi, Y.; Adams, J.; Catalano, O.; Scarisi, L.; Six, N. Frank (Technical Monitor)

    2002-01-01

    The Extreme Universe Space Observatory (EUSO) is a science mission under conceptual design for the detection of extremely high energy cosmic rays and neutrinos by the observation of time-resolved images of atmospheric fluorescence photons generated along the extensive air shower, in the near ultraviolet wavelength region. A refractive telescope with double-sided double Fresnel lens will be employed to achieve a large field of view of 60 degrees. The energy and arrival direction of the primary particles will be determined by observing the time evolution of the airshower. The focal surface of the EUSO telescope will be segmented to a few hundred thousand pixels to resolve the entire field of view with the angular resolution of the order of 0.1 degree. The time evolution will be observed with the time resolution of 0.8 microsecond. A large scale array of multianode photomultiplier (MAPMT) is being studied as the EUSO focal surface. The MAPMT array is capable of detecting near ultraviolet photons at single photoelectron level. In this contribution, we will report the present status of the focal surface design including the optimization of anode segmentation and the minimization of the dead area and discuss overall experimental performance in detecting extensive airshowers.

  18. Mechanism of Focal Adhesion Kinase Mechanosensing

    PubMed Central

    Sturm, Sebastian; Bullerjahn, Jakob Tómas; Bronowska, Agnieszka; Gräter, Frauke

    2015-01-01

    Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile forces, propagating from the membrane through the PIP2 binding site of the FERM domain and from the cytoskeleton-anchored FAT domain, activate FAK by unlocking its central phosphorylation site (Tyr576/577) from the autoinhibitory FERM domain. Varying loading rates, pulling directions, and membrane PIP2 concentrations corroborate the specific opening of the FERM-kinase domain interface, due to its remarkably lower mechanical stability compared to the individual alpha-helical domains and the PIP2-FERM link. Analyzing downstream signaling networks provides further evidence for an intrinsic mechano-signaling role of FAK in broadcasting force signals through Ras to the nucleus. This distinguishes FAK from hitherto identified focal adhesion mechano-responsive molecules, allowing a new interpretation of cell stretching experiments. PMID:26544178

  19. Multispectral linear array (MLA) focal plane mechanical and thermal design

    NASA Technical Reports Server (NTRS)

    Mitchell, A. S.; Kaminski, E. F.

    1982-01-01

    The mechanical and thermal design of an integrated focal plane subsystem of a Multispectral Linear Array (MLA) instrument is discussed in terms of focal-plane alignment, thermoelastic performance, and thermal requirements. The modular construction and thermal control of the focal plane array are discussed.

  20. The dynamic implication of focal mechanism solutions of Wenchuan earthquake sequence

    NASA Astrophysics Data System (ADS)

    Hu, X.; Cui, X.; Chen, L.

    2010-12-01

    At 14:28 CST on May 12, 2008, the disastrous MS8.0 Wenchuan earthquake took place in Sichuan province of China, followed by tens of thousands of aftershocks. It occurred on the Longmenshan fault zone which is a high-angle inland over-thrust fault. What is the corresponding tectonic implication behind the focal mechanism is an important issue to realize the dynamic mechanism of Wenchuan earthquake sequence. In order to reveal it, our research as following is carried out. 1) We extensively collected digital waveform records, seriously and strictly read out P wave first motion, used more accurate locating results, employed the improved grid point test method, computed the focal mechanism solutions of Wenchuan earthquake sequence, and gave out 125 reliable focal mechanism solutions (M≥4.0,including a M3.9 earthquake result). The result shows that most of the earthquakes are thrust or strike-slip. The focal mechanism solutions have characteristic of subsection distribution. The P axis mainly distribute in direction of E-W within a certain range. 2) According to the main faults information and fine medium parameters, using ANSYS software, we established a three-dimensional elastic finite element model of the Longmenshan fault zone and its surrounding areas. According to Global Position System observations, considering three representative patterns of tectonic deformation velocity varying with depth, we loaded three different boundary conditions and got each numerical simulation result of the tectonic stress field in this region. The simulation results of the three patterns consistently show that the orientation of the principal compressive stress is almost E-W in Longmenshan fault zone and its surrounding area. And from north to south, there is a clockwise rotation within a narrow range. The result is consistent with the previous research in these areas. 3) Based on the numerical simulation results of tectonic stress field of three structural deformation patterns

  1. Dynamic focal spots registration algorithm for freeform surface measurement

    NASA Astrophysics Data System (ADS)

    Guo, Wenjiang; Zhao, Liping; Chen, I.-Ming

    2013-06-01

    In a wavefront sensing system, the raw data for surface reconstruction, either the slope matrix or curvature matrix, is obtained through centroiding on the focal spot images. Centroiding is to calculate the first moment within a certain area of interest, which encloses the focal spot. As the distribution of focal spots is correlated to the surface sampling condition, while a uniform rectangular grid is good enough to register all the focal spots of a uniformly sampled near flat surface, the focal spots of aspherical or freeform surfaces have varying shapes and sizes depending on the surface geometry. In this case, the normal registration method is not applicable. This paper proposed a dynamic focal spots registration algorithm to automatically analyze the image, identify and register every focal spot for centroiding at one go. Through experiment on a freeform surface with polynomial coefficients up to 10th order, the feasibility and effectiveness of the proposed algorithm is proved.

  2. A kinetic model for RNA-interference of focal adhesions

    PubMed Central

    2013-01-01

    Background Focal adhesions are integrin-based cell-matrix contacts that transduce and integrate mechanical and biochemical cues from the environment. They develop from smaller and more numerous focal complexes under the influence of mechanical force and are key elements for many physiological and disease-related processes, including wound healing and metastasis. More than 150 different proteins localize to focal adhesions and have been systematically classified in the adhesome project (http://www.adhesome.org). First RNAi-screens have been performed for focal adhesions and the effect of knockdown of many of these components on the number, size, shape and location of focal adhesions has been reported. Results We have developed a kinetic model for RNA interference of focal adhesions which represents some of its main elements: a spatially layered structure, signaling through the small GTPases Rac and Rho, and maturation from focal complexes to focal adhesions under force. The response to force is described by two complementary scenarios corresponding to slip and catch bond behavior, respectively. Using estimated and literature values for the model parameters, three time scales of the dynamics of RNAi-influenced focal adhesions are identified: a sub-minute time scale for the assembly of focal complexes, a sub-hour time scale for the maturation to focal adhesions, and a time scale of days that controls the siRNA-mediated knockdown. Our model shows bistability between states dominated by focal complexes and focal adhesions, respectively. Catch bonding strongly extends the range of stability of the state dominated by focal adhesions. A sensitivity analysis predicts that knockdown of focal adhesion components is more efficient for focal adhesions with slip bonds or if the system is in a state dominated by focal complexes. Knockdown of Rho leads to an increase of focal complexes. Conclusions The suggested model provides a kinetic description of the effect of RNA

  3. Efficacy of lacosamide by focal seizure subtype.

    PubMed

    Sperling, Michael R; Rosenow, Felix; Faught, Edward; Hebert, David; Doty, Pamela; Isojärvi, Jouko

    2014-10-01

    The purpose of this post hoc exploratory analysis was to determine the effects of the antiepileptic drug, lacosamide, on focal (partial-onset) seizure subtypes. Patient data from the three lacosamide pivotal trials were grouped and pooled by focal seizure subtype at Baseline: simple partial seizures (SPS), complex partial seizures (CPS), and secondarily generalized partial seizures (SGPS). Both efficacy outcomes (median percent change from Baseline to Maintenance Phase in seizure frequency per 28 days and the proportion of patients experiencing at least a 50% reduction in seizures) were evaluated by lacosamide dose (200, 400, or 600 mg/day) compared to placebo for each seizure subtype. An additional analysis was performed to determine whether a shift from more severe focal seizure subtypes to less severe occurred upon treatment with lacosamide. In patients with CPS or SGPS at Baseline, lacosamide 400 mg/day (maximum recommended daily dose) and 600 mg/day reduced the frequency of CPS and SGPS compared to placebo. Likewise, a proportion of patients with CPS and SGPS at Baseline experienced at least a 50% reduction in the frequency of CPS and SGPS (≥50% responder rate) in the lacosamide 400 and 600 mg/day groups compared with placebo. For both outcomes, numerically greatest responses were observed in the lacosamide 600 mg/day group among patients with SGPS at Baseline. In patients with SPS at Baseline, no difference between placebo and lacosamide was observed for either efficacy outcome. An additional exploratory analysis suggests that in patients with SPS at Baseline, CPS and SGPS may have been shifted to less severe SPS upon treatment with lacosamide. The results of these exploratory analyses revealed reductions in CPS and SGPS frequency with adjunctive lacosamide. Reduction in CPS and SGPS may confound assessment of SPS since the CPS or SGPS may possibly change to SPS by effective treatment. PMID:25082395

  4. Focal hepatic infarction with bile lake formation

    SciTech Connect

    Peterson, I.M.; Neumann, C.H.

    1984-06-01

    Venous thrombosis associated with oral contraceptives is a well recognized phenomenon. Arterial thrombosis, while less common, is also a known risk, as evidenced by the increased incidence of cerebral vascular accidents and myocardial ischemia or infarction. The liver is relatively protected from the usual consequences of arterial thrombosis because of its dual blood supply. The authors present an unusual case of a young woman with a history of oral contraceptive and cigarette use who developed hepatic artery thrombosis and had focal liver lesions on computed tomography (CT) due to hepatic infarction and bile lake formation despite an intact portal venous system.

  5. Characterization of DECam focal plane detectors

    SciTech Connect

    Diehl, H.Thomas; Angstadt, Robert; Campa, Julia; Cease, Herman; Derylo, Greg; Emes, John H.; Estrada, Juan; Kibik, Donna; Flaugher, Brenna L.; Holland, Steve E.; Jonas, Michelle; /Fermilab /Madrid, CIEMAT /LBL, Berkeley /Argonne /Pennsylvania U.

    2008-06-01

    DECam is a 520 Mpix, 3 square-deg FOV imager being built for the Blanco 4m Telescope at CTIO. This facility instrument will be used for the 'Dark Energy Survey' of the southern galactic cap. DECam has chosen 250 ?m thick CCDs, developed at LBNL, with good QE in the near IR for the focal plane. In this work we present the characterization of these detectors done by the DES team, and compare it to the DECam technical requirements. The results demonstrate that the detectors satisfy the needs for instrument.

  6. Rapid acquisition of high-volume microscopic images using predicted focal plane.

    PubMed

    Yu, Lingjie; Wang, Rongwu; Zhou, Jinfeng; Xu, Bugao

    2016-09-01

    For an automated microscopic imaging system, the image acquisition speed is one of the most critical performance features because many applications require to analyse high-volume images. This paper illustrates a novel approach for rapid acquisition of high-volume microscopic images used to count blood cells automatically. This approach firstly forms a panoramic image of the sample slide by stitching sequential images captured at a low magnification, selects a few basic points (x, y) indicating the target areas from the panoramic image, and then refocuses the slide at each of the basic points at the regular magnification to record the depth position (z). The focusing coordinates (x, y, z) at these basic points are used to calculate a predicted focal plane that defines the relationship between the focus position (z) and the stage position (x, y). Via the predicted focal plane, the system can directly focus the objective lens at any local view, and can tremendously save image-acquisition time by avoiding the autofocusing function. The experiments showed how to determine the optimal number of the basic points at a given imaging condition, and proved that there is no significant difference between the images captured using the autofocusing function or the predicted focal plane. PMID:27229441

  7. Near-Field Imaging Based on High Resolution Focal Spot Properties

    NASA Astrophysics Data System (ADS)

    Hillers, G.; Campillo, M.; Ben-Zion, Y.; Roux, P.; Lecointre, A.; Vernon, F.

    2015-12-01

    The dense spatial wavefield sampling provided by modern seismological acquisitions allows the resolution of the near-field focal spot. The large-amplitude focal spot emerges from the superposition of a collapsing, time reversed wavefront. We discuss an imaging method that is based on high resolution reconstructions of the focal spot that is obtained from cross correlation. This approach exploits the dependence of the spot's shape on local properties of the propagation medium, i.e., the distance of the first zero crossing is proportional to the wave length. We construct noise correlation functions from data collected by a highly-dense Nodal array centered on the San Jacinto fault zone south of Anza. The focal spot can be obtained from the amplitude distributions at zero lag time. We repeat this analysis using each geophone location as the collapsing point to which the wave length estimate is related. The anisotropic intensity of the converging wavefields leads to distorted focal spots. In addition, strong body and fault zone waves that are associated with the complex fault zone structure prohibit the straightforward analysis of the spatially variable zero-lag time distributions. We discuss strategies to mute the influence of the wavefield anisotropy and the removal of the body and fault zone wave components for improved reconstructions of the symmetric surface wave focal spot. The overall consistency of the local wave speed estimates from the zero crossing and images obtained with more traditional far-field travel time inversions validates the near-field approach. We discuss causes for the remaining inconsistencies and compare limits of the resolution in both cases. At higher frequencies (>3 Hz) both methods reveal a heterogeneous velocity structure that exhibits pronounced low-velocity zones. In addition, near-field based images obtained at wave lengths that are too large for the application of far-field methods suggest a strong velocity contrast across the fault.

  8. Analyzing the characteristics of focal mechanism solutions of Wenchuan earthquake sequence

    NASA Astrophysics Data System (ADS)

    Cui, X.; Hu, X.; Xie, F.; Yu, C.; Wang, Y.

    2009-12-01

    We firstly read out initial P wave polarity from the digital wave form data given by Chinese national seismic networks, regional seismic networks, temporary seismic networks as well as some IRIS stations. Then employing improved grid point test method we obtain focal mechanism solutions of the strong aftershocks (M≥4.0) and composite fault plane solutions of the moderate and small aftershocks of Wenchuan earthquake sequence. In order to improve the reliability of focal mechanism solutions, we precisely locate the hypocenter location of aftershocks during the determining of focal mechanism solutions. Most of the aftershocks are thrust faulting or strike slip faulting except few ones. Thrust and predominately thrust aftershocks are distributed along the whole rapture zone except the southwest section, while strike slip aftershocks are distributed mainly in the southwest and the northeast sections. In the section from Beichuan to Pingwu, there are hardly any strike slip aftershocks but thrust and predominately thrust aftershocks. In terms of the azimuths of P axes of the focal mechanism solutions of the aftershocks, we find that the ones of the aftershocks with magnitude above 5.0 show good homogeneity, mainly concentrate on the orientation of NWW-SEE, which is consistent with that of Wenchuan mainshock, while as for aftershocks with magnitude below 4.9, they have two dominant distributions of NWW-SEE (azimuth 280°-310°) and NE-SW (azimuth 40°-70°). It shows that the focal mechanism solutions and their distribution characteristics of Wenchuan earthquake sequence are both complex. From the types and the azimuths of P axes of the focal mechanism solutions of the aftershocks, we can obtain the characteristics of segmentation, which is important to realize the dynamic mechanism of the Wenchuan earthquake sequence.

  9. Characterization of the KATRIN Focal Plane Detector

    NASA Astrophysics Data System (ADS)

    Bodine, Laura; Leber, Michelle; Myers, Allan; Tolich, Kazumi; Vandevender, Brent; Wall, Brandon

    2008-10-01

    The Karlsruhe Tritium Neutrino (KATRIN) Experiment is a next generation tritium beta decay experiment designed to measure directly the electron neutrino mass with a sensitivity of 0.2 eV. In the experiment, electrons from tritium decay of a gaseous source are magnetically guided through analyzing solenoidal retarding electrostatic spectrometers and detected via a focal plane detector. The focal plane detector is a 90mm diameter, 500 micron thick monolithic silicon pin-diode array with 148 pixels. The diode contacts have a titanium nitride overlayer and are connected to preamplifiers via an array of spring-loaded pogo pins. This novel connection scheme minimizes backgrounds from radioactive materials near the detector, facilitates characterization and replacement of the detector wafer, but requires a unique mounting design. The force of the pins strains the silicon, possibly altering the detector properties and performance. Results on the mechanical, thermal and electrical performance of a prototype detector under stress from pogo pin readouts will be presented.

  10. Visual function and perinatal focal cerebral infarction.

    PubMed Central

    Mercuri, E; Atkinson, J; Braddick, O; Anker, S; Nokes, L; Cowan, F; Rutherford, M; Pennock, J; Dubowitz, L

    1996-01-01

    AIMS: To evaluate the visual function of infants with perinatal cerebral infarction in whom the site and size of the lesion has been determined using magnetic resonance imaging (MRI). METHODS: Twelve infants with cerebral infarction on MRI were studied with a battery of tests specifically designed to evaluate visual function in infancy. This included tests: for visual attention (fixation shifts); of cerebral asymmetry (optokinetic nystagmus, visual fields); for assessment of acuity (forced choice preferential looking); and neurophysiological measures of vision (phase reversal and orientation reversal visual evoked potential). RESULTS: A considerable incidence of abnormalities on at least one of the tests for visual function used was observed. The presence or severity of visual abnormalities could not always be predicted by the site and extent of the lesion seen on imaging. CONCLUSIONS: Early focal lesions affecting the visual pathway can, to some extent, be compensated for by the immature developing brain. These data suggest that all the infants presenting with focal lesions need to be investigated with a detailed assessment of various aspects of vision. Images PMID:8949687

  11. Idiopathic focal epilepsies: the "lost tribe".

    PubMed

    Pal, Deb K; Ferrie, Colin; Addis, Laura; Akiyama, Tomoyuki; Capovilla, Giuseppe; Caraballo, Roberto; de Saint-Martin, Anne; Fejerman, Natalio; Guerrini, Renzo; Hamandi, Khalid; Helbig, Ingo; Ioannides, Andreas A; Kobayashi, Katsuhiro; Lal, Dennis; Lesca, Gaetan; Muhle, Hiltrud; Neubauer, Bernd A; Pisano, Tiziana; Rudolf, Gabrielle; Seegmuller, Caroline; Shibata, Takashi; Smith, Anna; Striano, Pasquale; Strug, Lisa J; Szepetowski, Pierre; Valeta, Thalia; Yoshinaga, Harumi; Koutroumanidis, Michalis

    2016-09-01

    The term idiopathic focal epilepsies of childhood (IFE) is not formally recognised by the ILAE in its 2010 revision (Berg et al., 2010), nor are its members and boundaries precisely delineated. The IFEs are amongst the most commonly encountered epilepsy syndromes affecting children. They are fascinating disorders that hold many "treats" for both clinicians and researchers. For example, the IFEs pose many of the most interesting questions central to epileptology: how are functional brain networks involved in the manifestation of epilepsy? What are the shared mechanisms of comorbidity between epilepsy and neurodevelopmental disorders? How do focal EEG discharges impact cognitive functioning? What explains the age-related expression of these syndromes? Why are EEG discharges and seizures so tightly locked to slow-wave sleep? In the last few decades, the clinical symptomatology and the respective courses of many IFEs have been described, although they are still not widely appreciated beyond the specialist community. Most neurologists would recognise the core syndromes of IFE to comprise: benign epilepsy of childhood with centro-temporal spikes or Rolandic epilepsy (BECTS/RE); Panayiotopoulos syndrome; and the idiopathic occipital epilepsies (Gastaut and photosensitive types). The Landau-Kleffner syndrome and the related (idiopathic) epilepsy with continuous spikes and waves in sleep (CSWS or ESES) are also often included, both as a consequence of the shared morphology of the interictal discharges and their potential evolution from core syndromes, for example, CSWS from BECTS. Atypical benign focal epilepsy of childhood also has shared electro-clinical features warranting inclusion. In addition, a number of less well-defined syndromes of IFE have been proposed, including benign childhood seizures with affective symptoms, benign childhood epilepsy with parietal spikes, benign childhood seizures with frontal or midline spikes, and benign focal seizures of adolescence. The

  12. Focal embolic cerebral ischemia in the rat

    PubMed Central

    Zhang, Li; Zhang, Rui Lan; Jiang, Quan; Ding, Guangliang; Chopp, Michael; Zhang, Zheng Gang

    2015-01-01

    Animal models of focal cerebral ischemia are well accepted for investigating the pathogenesis and potential treatment strategies for human stroke. Occlusion of the middle cerebral artery (MCA) with an endovascular filament is a widely used model to induce focal cerebral ischemia. However, this model is not amenable to thrombolytic therapies. As thrombolysis with recombinant tissue plasminogen activator (rtPA) is a standard of care within 4.5 hours of human stroke onset, suitable animal models that mimic cellular and molecular mechanisms of thrombosis and thrombolysis of stroke are required. By occluding the MCA with a fibrin-rich allogeneic clot, we have developed an embolic model of MCA occlusion in the rat, which recapitulates the key components of thrombotic development and of thrombolytic therapy of rtPA observed from human ischemic stroke. The surgical procedures of our model can be typically completed within approximately 30 min and are highly adaptable to other strains of rats as well as mice for both genders. Thus, this model provides a powerful tool for translational stroke research. PMID:25741989

  13. Posttraumatic focal dystonia of the shoulder.

    PubMed

    Vasileiadis, Georgios I; Sakellariou, Vasileios I; Papagelopoulos, Panayiotis J; Zoubos, Aristeides B

    2012-06-01

    Focal posttraumatic shoulder dystonia is a rare and not easily identifiable entity. Its true pathophysiologic nature, predisposing factors, and disease course remain debatable.This article describes a rare case of a 40-year-old man with late symptoms of focal shoulder dystonia after peripheral trauma of his left shoulder girdle. The shoulder was indirectly injured from the impact of a fall off his motorbike 3 years earlier. He was referred to the authors' institution because remarkable reduction of arm abduction, muscle spasms, and circumscribed hypertrophy of the trapezius muscle were noted while his head and neck were in neutral position and had a full range of motion. The left shoulder had a fixed elevated posture compared with the contralateral shoulder. A continuous burning pain was localized over the area of the hypertrophied trapezius muscle, radiating to the ipsilateral side of the head and neck. Dystonic movements of the trapezius, rhomboid, and supraspinatus muscles were observed. The abduction of the shoulder was significantly decreased, and any repetitive effort for arm abduction induced an exaggeration of his movement disorder, leading to a more pronounced shoulder elevation.Plain radiographs and magnetic resonance imaging of the left shoulder revealed a suprascapular tendinitis with no other abnormalities. Repeated needle electromyography of the left trapezius muscle and neurography of the accessory nerve on both sides were normal. Injections of botulinum toxin A were effective in the resolution of muscle hypertrophy and abnormal posture. PMID:22691679

  14. Drug discovery in focal and segmental glomerulosclerosis.

    PubMed

    Pullen, Nick; Fornoni, Alessia

    2016-06-01

    Despite the high medical burden experienced by patients with focal segmental glomerulosclerosis, the etiology of the condition remains largely unknown. Focal segmental glomerulosclerosis is highly heterogeneous in clinical and morphologic manifestations. While this presents challenges for the development of new treatments, research investments over the last 2 decades have yielded a surfeit of potential avenues for therapeutic intervention. The development of many of those ideas and concepts into new therapies, however, has been very disappointing. Here, we describe some of the factors that have potentially contributed to the poor translational performance from this research investment, including the confidence we ascribe to a target, the conduct of experimental studies, and the availability of selective reagents to test hypotheses. We will discuss the significance of genetic and systems traits as well as other methods for reducing bias. We will analyze the limitations of a successful drug development. We will use specific examples hoping that these will guide a consensus for investment and drive greater translational quality. We hope that this substrate will serve to exemplify the tremendous opportunity for intervention as well as facilitate greater collaborative effort between industry, academia, and private foundations in promoting appropriate validation of these targets. Only then will we have achieved our goal for curative therapies for this devastating disease. PMID:27165834

  15. Short Wavelength Infrared Hybrid Focal Plane Arrays

    NASA Astrophysics Data System (ADS)

    Vural, K.; Blackwell, J. D...; Marin, E. C.; Edwall, D. D...; Rode, J. P.

    1983-11-01

    Short wavelength (λc = 2.5 μm) 32 x 32 HgCdTe focal plane arrays have been fabricated for use in an Airborne Imaging Spectrometer (AIS) developed by the Jet Propulsion Labora-tory for NASA. An Imaging Spectrometer provides simultaneous imaging of several spectral bands for applications in the sensing and monitoring of earth resources. The detector material is HgCdTe grown on CdTe substrates using liquid phase epitaxy. Planar processing is used to make photovoltaic detectors on 68 um centers. The detector array is mated to a silicon charge coupled device multiplexer to make hybrid focal plane arrays. Results show high performance detectors with a mean RoA = 9.6 x 107 Ω --cm2 and IleakAge (-100 mV) = 0.037 pA at 120K and near zero background. The yield and uniformity are high. The ratio of the standard deviation of the dc responsivity to the mean is 3% for 98.5% of the pixels. The D1.0 = 1.3 x 1012 cm - âœ"fiz/W at a background of 1013 ph/cm2-s and 120K which is close to the background limited (BLIP) D* of 1.9 x 1012 cm- âœ"Hz/W.

  16. ORFEUS focal plane instrumentation: The Berkeley spectrometer

    NASA Technical Reports Server (NTRS)

    Hurwitz, Mark; Bowyer, Stuart

    1988-01-01

    A spectrograph for the ORFEUS mission that incorporates four varied line-space, spherically figured diffraction gratings was designed. The ORFEUS, a 1-m normal incidence telescope is equipped with 2 focal plane spectrographs. The Berkeley spectrograph was developed with an optimizing raytracing computer code. Each grating accepts the light from 20 percent of the aperture of the telescope primary mirror and has a unique set of characteristics to cover a sub-bandpass within the 390 to 1200 A spectral range. Two photon-counting detectors incorporating a time delay readout system are used to record the spectra from all four gratings simultaneously. The nominal design achieves a spectral resolution (FWHM) in excess of 5500 at all wavelengths within the bandpass. The resolution is limited primarily by the detector spatial resolution. The 1 sigma astigmatism of this design varies between 13 and 150 micrometer on the same focal surface. An independent, direct imaging system tracks the drift of the target within the spectrometer aperture and allows measurement of the misalignment between the telescope optical axis and that of the external star tracker. The resolution and astigmatism achievable with this design are superior to those of a standard Rowland spectrograph designed with the same constraints.

  17. The Piriform Cortex and Human Focal Epilepsy

    PubMed Central

    Vaughan, David N.; Jackson, Graeme D.

    2014-01-01

    It is surprising that the piriform cortex, when compared to the hippocampus, has been given relatively little significance in human epilepsy. Like the hippocampus, it has a phylogenetically preserved three-layered cortex that is vulnerable to excitotoxic injury, has broad connections to both limbic and cortical areas, and is highly epileptogenic – being critical to the kindling process. The well-known phenomenon of early olfactory auras in temporal lobe epilepsy highlights its clinical relevance in human beings. Perhaps because it is anatomically indistinct and difficult to approach surgically, as it clasps the middle cerebral artery, it has, until now, been understandably neglected. In this review, we emphasize how its unique anatomical and functional properties, as primary olfactory cortex, predispose it to involvement in focal epilepsy. From recent convergent findings in human neuroimaging, clinical epileptology, and experimental animal models, we make the case that the piriform cortex is likely to play a facilitating and amplifying role in human focal epileptogenesis, and may influence progression to epileptic intractability. PMID:25538678

  18. Multiple molecular penumbras after focal cerebral ischemia.

    PubMed

    Sharp, F R; Lu, A; Tang, Y; Millhorn, D E

    2000-07-01

    Though the ischemic penumbra has been classically described on the basis of blood flow and physiologic parameters, a variety of ischemic penumbras can be described in molecular terms. Apoptosis-related genes induced after focal ischemia may contribute to cell death in the core and the selective cell death adjacent to an infarct. The HSP70 heat shock protein is induced in glia at the edges of an infarct and in neurons often at some distance from the infarct. HSP70 proteins are induced in cells in response to denatured proteins that occur as a result of temporary energy failure. Hypoxia-inducible factor (HIF) is also induced after focal ischemia in regions that can extend beyond the HSP70 induction. The region of HIF induction is proposed to represent the areas of decreased cerebral blood flow and decreased oxygen delivery. Immediate early genes are induced in cortex, hippocampus, thalamus, and other brain regions. These distant changes in gene expression occur because of ischemia-induced spreading depression or depolarization and could contribute to plastic changes in brain after stroke. PMID:10908035

  19. Focal Adhesion Kinase-Dependent Regulation of Adhesive Force Involves Vinculin Recruitment to Focal Adhesions

    PubMed Central

    Hanks, Steven K.; García, Andrés J.

    2016-01-01

    Background information Focal adhesion kinase (FAK), an essential non-receptor tyrosine kinase, plays pivotal roles in migratory responses, adhesive signaling, and mechanotransduction. FAK-dependent regulation of cell migration involves focal adhesion turnover dynamics as well as actin cytoskeleton polymerization and lamellipodia protrusion. Whereas roles for FAK in migratory and mechanosensing responses have been established, the contributions of FAK to the generation of adhesive forces are not well understood. Results Using FAK-null cells expressing wild-type and mutant FAK under an inducible tetracycline promoter, we analyzed the role of FAK in the generation of steady-state adhesive forces using micropatterned substrates and a hydrodynamic adhesion assay. FAK expression reduced steady-state strength by 30% compared to FAK-null cells. FAK expression reduced vinculin localization to focal adhesions by 35% independently from changes in integrin binding and localization of talin and paxillin. RNAi knockdown of vinculin abrogated the FAK-dependent differences in adhesive force. FAK-dependent changes in vinculin localization and adhesive force were confirmed in human primary fibroblasts with FAK knocked down by RNAi. The autophosphorylation Y397 and kinase domain Y576/Y577 sites were differentially required for FAK-mediated adhesive responses. Conclusions We demonstrate that FAK reduces steady-state adhesion strength by modulating vinculin recruitment to focal adhesions. These findings provide insights into the role of FAK in mechanical interactions between a cell and the extracellular matrix. PMID:19883375

  20. Phase-Scrambler Plate Spreads Point Image

    NASA Technical Reports Server (NTRS)

    Edwards, Oliver J.; Arild, Tor

    1992-01-01

    Array of small prisms retrofit to imaging lens. Phase-scrambler plate essentially planar array of small prisms partitioning aperture of lens into many subapertures, and prism at each subaperture designed to divert relatively large diffraction spot formed by that subaperture to different, specific point on focal plane.

  1. TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility

    PubMed Central

    Cáceres, Mónica; Ortiz, Liliana; Recabarren, Tatiana; Romero, Anibal; Colombo, Alicia; Leiva-Salcedo, Elías; Varela, Diego; Rivas, José; Silva, Ian; Morales, Diego; Campusano, Camilo; Almarza, Oscar; Simon, Felipe; Toledo, Hector; Park, Kang-Sik; Trimmer, James S.; Cerda, Oscar

    2015-01-01

    Cellular migration and contractility are fundamental processes that are regulated by a variety of concerted mechanisms such as cytoskeleton rearrangements, focal adhesion turnover, and Ca2+ oscillations. TRPM4 is a Ca2+-activated non-selective cationic channel (Ca2+-NSCC) that conducts monovalent but not divalent cations. Here, we used a mass spectrometry-based proteomics approach to identify putative TRPM4-associated proteins. Interestingly, the largest group of these proteins has actin cytoskeleton-related functions, and among these nine are specifically annotated as focal adhesion-related proteins. Consistent with these results, we found that TRPM4 localizes to focal adhesions in cells from different cellular lineages. We show that suppression of TRPM4 in MEFs impacts turnover of focal adhesions, serum-induced Ca2+ influx, focal adhesion kinase (FAK) and Rac activities, and results in reduced cellular spreading, migration and contractile behavior. Finally, we demonstrate that the inhibition of TRPM4 activity alters cellular contractility in vivo, affecting cutaneous wound healing. Together, these findings provide the first evidence, to our knowledge, for a TRP channel specifically localized to focal adhesions, where it performs a central role in modulating cellular migration and contractility. PMID:26110647

  2. Focal plane actuation for the development of a high resolution suborbital telescope

    NASA Astrophysics Data System (ADS)

    Duke Miller, Alex; Scowen, Paul A.; Veach, Todd

    2016-01-01

    We present a hexapod stabilized focal plane as the key instrument for a proposed suborbital balloon mission. Balloon gondolas currently achieve 1-2 arcsecond pointing error, but cannot correct for unavoidable jitter movements (~50μm at 20hz) caused by wind rushing over balloon surfaces, thermal variations, cryocoolers, and reaction wheels. The jitter causes image blur during exposures and is the limiting resolution of the system. To solve this, the hexapod system actuates the focal plane to counteract the jitter through real-time closed loop feedback from star-trackers. Removal of this final jitter term decreases pointing error by an order of magnitude and allows for true diffraction-limited observation. This boost in resolution will allow for Hubble-quality imaging for a fraction of the cost. Tip-tilt pointing systems have been used for these purposes in the past, but require additional optics and introduce multiple reflections. The hexapod system, rather, is compact and can be plugged into the focal point of nearly any configuration. The design also thermally isolates the hexapod from the cryogenic focal plane enabling the use of well-established non-cryogenic hexapod technology. High-resolution time domain multispectral imaging of the gas giant outer planets, especially in the UV range, is of particular interest to the planetary community, and a suborbital telescope with the hexapod stabilization in place would provide a wealth of new data. On an Antarctic ~100-day Long-Duration-Balloon mission the continued high-resolution imaging of gas giant storm systems would provide cloud formation and evolution data second to only a Flagship orbiter.

  3. Stress analysis of the space telescope focal plane structure joint

    NASA Technical Reports Server (NTRS)

    Foster, W. A., Jr.; Shoemaker, W. L.

    1985-01-01

    Two major efforts were begun concerning the Space Telescope focal plane structure joint. The 3-D solid finite element modeling of the bipod flexure plate was carried out. Conceptual models were developed for the load transfer through the three major bolts to the flexure plate. The flexure plate drawings were reconstructed using DADAM for the purpose of developing a file from which the coordinates of any point on the flexure plate could be determined and also to locate the attachment points of the various components which connect with the flexure plate. For modeling convenience the CADAM drawing of the flexure plate has been divided into several regions which will be subdivided into finite elements using MSGMESH, which is a finite element mesh generator available with MSC/NASTRAN. In addition to the CADAM work on the flexure plate, an effort was also begun to develop computer aided drawings of the peripheral beam which will be used to assist in modeling the connection between it and the flexure plate.

  4. Deep Moonquake Focal Mechanisms: Recovery and Implications

    NASA Technical Reports Server (NTRS)

    Knapmeyer, Martin; Weber, Renee C.

    2011-01-01

    A defining characteristic of deep moonquakes is their tendency to occur with tidal periodicity, prompting previous studies to infer that they are related to the buildup and release of tidal stress within the Moon. In studies of tidal forcing, a key constraint is the focal mechanism: the fault parameters describing the type of failure moonquakes represent. The quality of the lunar seismic data and the limited source/receiver geometries of the Apollo seismic network prohibit the determination of deep moonquake fault parameters using first-motion polarities, as is typically done in terrestrial seismology. Without being able to resolve tidal stress onto a known failure plane, we can examine only gross qualities of the tidal stress tensor with respect to moonquake occurrence, so we cannot fully address the role of tidal stress in moonquake generation. We will examine the extent to which shear (S) and compression (P) wave amplitude ratios can constrain moonquake fault geometry by determining whether, for a given cluster, there exists a focal mechanism that can produce a radiation pattern consistent with the amplitudes measured by the Apollo instruments. Amplitudes are read in the ray coordinate frame, directly from seismograms for which the P and S arrivals are clearly identifiable on all long-period channels of the four Apollo stations. We apply an empirical station correction to account for site effects and the differences between P- and S-wave attenuation. Instead of focusing on the best fitting solution only, we formulate the inverse problem using a falsification criterion: all source orientations that do not reproduce the observed SV/P ratios within an error margin derived from the uncertainty of amplitude readings are rejected. All others are accepted as possible solutions. The inversion is carried out using an exhaustive grid search on a regular grid with predefined step size, encompassing all possible combinations of strike, dip and slip. To assess the

  5. High-Resolution Quantification of Focal Adhesion Spatiotemporal Dynamics in Living Cells

    PubMed Central

    Hahn, Klaus M.; Gomez, Shawn M.

    2011-01-01

    Focal adhesions (FAs) are macromolecular complexes that provide a linkage between the cell and its external environment. In a motile cell, focal adhesions change size and position to govern cell migration, through the dynamic processes of assembly and disassembly. To better understand the dynamic regulation of focal adhesions, we have developed an analysis system for the automated detection, tracking, and data extraction of these structures in living cells. This analysis system was used to quantify the dynamics of fluorescently tagged Paxillin and FAK in NIH 3T3 fibroblasts followed via Total Internal Reflection Fluorescence Microscopy (TIRF). High content time series included the size, shape, intensity, and position of every adhesion present in a living cell. These properties were followed over time, revealing adhesion lifetime and turnover rates, and segregation of properties into distinct zones. As a proof-of-concept, we show how a single point mutation in Paxillin at the Jun-kinase phosphorylation site Serine 178 changes FA size, distribution, and rate of assembly. This study provides a detailed, quantitative picture of FA spatiotemporal dynamics as well as a set of tools and methodologies for advancing our understanding of how focal adhesions are dynamically regulated in living cells. A full, open-source software implementation of this pipeline is provided at http://gomezlab.bme.unc.edu/tools. PMID:21779367

  6. Tie-In Orbits for the Focal Plane Stability Test - Part 2

    NASA Astrophysics Data System (ADS)

    Abramowicz-Reed, Linda

    1991-07-01

    This proposal is part of the TTSC request entitled, "Distortion Calibration in FGS 1 and FGS 2, FGS-to-FGS Alignment Calibration". This portion is listed separately due to the time critical nature of one of the orbits. OFAD in FGS 3 which will be performed in December 1992 together with the Mini OFAD's in FGS's 1 and 2 which will be performed in January 1993 will provide a new set of FGS calibration parameters. One of the objectives of the STScI Focal Plane Stability test is to monitor changes to these parameters by repeatedly observing targets in the cluster M35. Since the cluster is near the ecliptic, only two vehicle orientations are needed, the "fall" and the "spring" pointings (see attached pickles plots). Since the Mini OFAD targets are not necessarily the same targets used in the Focal Plane Stability Test, tie in orbits using the Focal Plane Stability targets are needed shortly before and after the Mini OFAD activities. In addition, the Focal Plane Stability Test may not be

  7. Microlenses focal length measurement using Z-scan and parallel moiré deflectometry

    NASA Astrophysics Data System (ADS)

    Rasouli, Saifollah; Rajabi, Y.; Sarabi, H.

    2013-12-01

    In this paper, a simple and accurate method based on Z-scan and parallel moiré deflectometry for measuring the focal length of microlenses is reported. A laser beam is focused by one lens and is re-collimated by another lens, and then strikes a parallel moiré deflectometer. In the presence of a microlens near the focal point of the first lens, the radius of curvature of the beam is changed; the parallel moiré fringes are formed only due to the beam divergence or convergence. The focal length of the microlens is obtained from the moiré fringe period graph without the need to know the position of the principal planes. This method is simple, more reliable, and completely automated. The implementation of the method is straightforward. Since a focused laser beam and Z-scan in free space are used, it can be employed for determining small focal lengths of small size microlenses without serious limitation on their size.

  8. Oral focal mucinosis of palatal mucosa: A rare case report

    PubMed Central

    Bharti, Vipin; Singh, Jagmohan

    2012-01-01

    Oral focal mucinosis (OFM), an oral counterpart of cutaneous focal mucinosis, is a rare disease of unknown etiology. Its pathogenesis may be due to the overproduction of hyaluronic acid by a fibroblast, at the expense of collagen production, resulting in focal myxoid degeneration of the connective tissue, primarily affecting the mucosa overlying the bone. It has no distinctive clinical features, as the diagnosis is solely based on the histopathological features. This article reports of a 32-year-old female having the rare disease of oral focal mucinosis, involving the posterior palatal mucosa, and discusses its clinicopathological features and differential diagnosis of myxomatous lesions of the oral cavity. PMID:23230367

  9. Smart trigger logic for focal plane arrays

    SciTech Connect

    Levy, James E; Campbell, David V; Holmes, Michael L; Lovejoy, Robert; Wojciechowski, Kenneth; Kay, Randolph R; Cavanaugh, William S; Gurrieri, Thomas M

    2014-03-25

    An electronic device includes a memory configured to receive data representing light intensity values from pixels in a focal plane array and a processor that analyzes the received data to determine which light values correspond to triggered pixels, where the triggered pixels are those pixels that meet a predefined set of criteria, and determines, for each triggered pixel, a set of neighbor pixels for which light intensity values are to be stored. The electronic device also includes a buffer that temporarily stores light intensity values for at least one previously processed row of pixels, so that when a triggered pixel is identified in a current row, light intensity values for the neighbor pixels in the previously processed row and for the triggered pixel are persistently stored, as well as a data transmitter that transmits the persistently stored light intensity values for the triggered and neighbor pixels to a data receiver.

  10. Deep Moonquake Focal Mechanisms: Recovery and Implications

    NASA Technical Reports Server (NTRS)

    Weber, Renee C.; Knapmeyer, Martin

    2012-01-01

    A defining characteristic of deep moonquakes is their tendency to occur with tidal periodicity, prompting previous studies to infer that they are related to the buildup and release of tidal stress within the Moon [refs]. In studies of tidal forcing, a key constraint is the focal mechanism: the fault parameters describing the type of failure moonquakes represent. The quality of the lunar seismic data and the limited source/receiver geometries of the Apollo seismic network prohibit the determination of deep moonquake fault parameters using first-motion polarities, as is typically done in terrestrial seismology [ref]. Without being able to resolve tidal stress onto a known failure plane, we can examine only gross qualities of the tidal stress tensor with respect to moonquake occurrence, so we cannot fully address the role of tidal stress in moonquake generation.

  11. Decreased subcortical cholinergic arousal in focal seizures

    PubMed Central

    Motelow, Joshua E.; Li, Wei; Zhan, Qiong; Mishra, Asht M.; Sachdev, Robert N. S.; Liu, Geoffrey; Gummadavelli, Abhijeet; Zayyad, Zaina; Lee, Hyun Seung; Chu, Victoria; Andrews, John P.; Englot, Dario J.; Herman, Peter; Sanganahalli, Basavaraju G.; Hyder, Fahmeed; Blumenfeld, Hal

    2015-01-01

    SUMMARY Impaired consciousness in temporal lobe seizures has a major negative impact on quality of life. The prevailing view holds that this disorder impairs consciousness by seizure spread to the bilateral temporal lobes. We propose instead that seizures invade subcortical regions and depress arousal, causing impairment through decreases rather than through increases in activity. Using functional magnetic resonance imaging in a rodent model, we found increased activity in regions known to depress cortical function including lateral septum and anterior hypothalamus. Importantly, we found suppression of intralaminar thalamic and brainstem arousal systems and suppression of the cortex. At a cellular level, we found reduced firing of identified cholinergic neurons in the brainstem pedunculopontine tegmental nucleus and basal forebrain. Finally, we used enzyme-based amperometry to demonstrate reduced cholinergic neurotransmission in both cortex and thalamus. Decreased subcortical arousal is a novel mechanism for loss of consciousness in focal temporal lobe seizures. PMID:25654258

  12. Design of large aperture focal plane shutter

    NASA Astrophysics Data System (ADS)

    Hu, Jia-wen; Ma, Wen-li; Huang, Jin-long

    2012-09-01

    To satisfy the requirement of large telescope, a large aperture focal plane shutter with aperture size of φ200mm was researched and designed to realize, which could be started and stopped in a relative short time with precise position, and also the blades could open and close at the same time at any orientation. Timing-belts and stepper motors were adopted as the drive mechanism. Velocity and position of the stepper motors were controlled by the PWM pulse generated by DSP. Exponential curve is applied to control the velocity of the stepper motors to make the shutter start and stop in a short time. The closing/open time of shutter is 0.2s, which meets the performance requirements of large telescope properly.

  13. Short wavelength infrared hybrid focal plane arrays

    NASA Technical Reports Server (NTRS)

    Vural, K.; Blackwell, J. D.; Marin, E. C.; Edwall, D. D.; Rode, J. P.

    1983-01-01

    The employment of area focal plane arrays (FPA) has made it possible to obtain second generation infrared imaging systems with high resolution and sensitivity. The Short Wavelength Infrared (SWIR) region (1-2.5 microns) is of importance for imaging objects at high temperature and under conditions of reflected sunlight. The present investigation is concerned with electrooptical characterization results for 32 x 32 SWIR detector arrays and FPAs which are suitable for use in a prototype imaging spectrometer. The employed detector material is Hg(1-x)Cd(x)Te grown by liquid phase epitaxy on a CdTe transparent substrate. Attention is given to details of processing, the design of the detector array, the multiplexer, the fabrication of the hybrid FPA, and aspects of performance.

  14. Infrared focal plane array crosstalk measurement

    NASA Astrophysics Data System (ADS)

    Dang, Khoa V.; Kauffman, Christopher L.; Derzko, Zenon I.

    1992-07-01

    Crosstalk between two neighboring elements in a focal plane array (FPA) occurs when signal incident on one element in the array is seen on another. This undesired effect can occur due to both the electrical and optical properties of the FPA. An effort is underway at the U.S. Army's Night Vision and Electro-Optics Directorate to develop a capability to measure crosstalk on both mid-wave infrared and long-wave infrared FPAs. A single detector in an array is illuminated using a laser source coupled with a beam expander, collimating lens, and focusing lens. The relative response of that detector to that of its neighboring detectors is measured to calculate crosstalk. The various components of the test station, the methodology for implementing the crosstalk measurement, and a model of the laser spot size are discussed.

  15. Focal cortical dysplasias in autism spectrum disorders

    PubMed Central

    2013-01-01

    Background Previous reports indicate the presence of histological abnormalities in the brains of individuals with autism spectrum disorders (ASD) suggestive of a dysplastic process. In this study we identified areas of abnormal cortical thinning within the cerebral cortex of ASD individuals and examined the same for neuronal morphometric abnormalities by using computerized image analysis. Results The study analyzed celloidin-embedded and Nissl-stained serial full coronal brain sections of 7 autistic (ADI-R diagnosed) and 7 age/sex-matched neurotypicals. Sections were scanned and manually segmented before implementing an algorithm using Laplace’s equation to measure cortical width. Identified areas were then subjected to analysis for neuronal morphometry. Results of our study indicate the presence within our ASD population of circumscribed foci of diminished cortical width that varied among affected individuals both in terms of location and overall size with the frontal lobes being particularly involved. Spatial statistic indicated a reduction in size of neurons within affected areas. Granulometry confirmed the presence of smaller pyramidal cells and suggested a concomitant reduction in the total number of interneurons. Conclusions The neuropathology is consistent with a diagnosis of focal cortical dysplasia (FCD). Results from the medical literature (e.g., heterotopias) and our own study suggest that the genesis of this cortical malformation seemingly resides in the heterochronic divisions of periventricular germinal cells. The end result is that during corticogenesis radially migrating neuroblasts (future pyramidal cells) are desynchronized in their development from those that follow a tangential route (interneurons). The possible presence of a pathological mechanism in common among different conditions expressing an autism-like phenotype argue in favor of considering ASD a “sequence” rather than a syndrome. Focal cortical dysplasias in ASD may serve to

  16. Focal symmetrical encephalomalacia in a goat.

    PubMed

    Oliveira, Diego M; Pimentel, Luciano A; Pessoa, André F; Dantas, Antônio F M; Uzal, Francisco; Riet-Correa, Franklin

    2010-09-01

    Focal symmetrical encephalomalacia (FSE) is the most prominent lesion seen in the chronic form of enterotoxemia caused by Clostridium perfringens type D in sheep. However, this lesion has not been reported in goats. The current paper reports a case of FSE in a goat from the state of Paraíba in the Brazilian semiarid region. As reported by the farmer, 30, 4-48-month-old animals from a flock of 150 goats died after showing nervous signs, including blindness and recumbence, for periods varying between 1 and 14 days. The flock was grazing native pasture supplemented with wheat and corn bran. Additionally, lactating goats were supplemented with soybeans. A 4-month-old goat with nervous signs was examined clinically and then necropsied 3 days after the onset of clinical signs. Bilateral, focal, and symmetrical areas of brown discoloration were observed in the internal capsule and thalamus. Histologic lesions in these areas consisted of multifocal, bilateral malacia with a few neutrophils; endothelial cell swelling; perivascular edema; and hemorrhages. The etiology of these lesions was not determined. However, FSE is considered pathognomonic for C. perfringens type D enterotoxemia in sheep, and it is speculated that this microorganism was the etiologic agent in the present case. The flock had been vaccinated against type D enterotoxemia only once, approximately 3 months before the beginning of the outbreak. Insufficient immunity due to the incorrect vaccination protocol, low efficacy of the vaccine used, and a diet including large amounts of highly fermentable carbohydrates were suspected to be predisposing factors for this outbreak. PMID:20807946

  17. Sighting optics including an optical element having a first focal length and a second focal length and methods for sighting

    DOEpatents

    Crandall, David Lynn

    2011-08-16

    Sighting optics include a front sight and a rear sight positioned in a spaced-apart relation. The rear sight includes an optical element having a first focal length and a second focal length. The first focal length is selected so that it is about equal to a distance separating the optical element and the front sight and the second focal length is selected so that it is about equal to a target distance. The optical element thus brings into simultaneous focus for a user images of the front sight and the target.

  18. Microtubules Regulate Focal Adhesion Dynamics through MAP4K4

    PubMed Central

    Yue, Jiping; Xie, Min; Gou, Xuewen; Lee, Philbert; Schneider, Michael D; Wu, Xiaoyang

    2014-01-01

    Disassembly of focal adhesions (FAs) allows cell retraction and integrin detachment from the ECM, processes critical for cell movement. Growth of MT (microtubule) can promote FA turnover by serving as tracks to deliver proteins essential for FA disassembly. The molecular nature of this FA “disassembly factor”, however, remains elusive. By quantitative proteomics, we identified MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4) as a FA regulator that associates with MTs. Conditional knockout (cKO) of MAP4K4 in skin stabilizes FAs and impairs epidermal migration. By exploring underlying mechanisms, we further show that MAP4K4 associates with EB2, a MT binding protein, and IQSEC1, a guanine nucleotide exchange factor (GEF) specific for Arf6, whose activation promotes integrin internalization. Together, our findings provide critical insights into FA disassembly, suggesting that MTs can deliver MAP4K4 toward FAs through EB2, where MAP4K4 can in turn activate Arf6 via IQSEC1 and enhance FA dissolution. PMID:25490267

  19. [Color Doppler sonography of focal abdominal lesions].

    PubMed

    Licanin, Zoran; Lincender, Lidija; Djurović, V; Salihefendić, Nizama; Smajlović, Fahrudin

    2004-01-01

    Color Doppler sonography (CDS--spectral, color and power), harmonic imaging techniques (THI, PHI), possibility of 3D analysis of picture, usage of contrast agents, have raised the values of ultrasound as a diagnostic method to a very high level. THI--non-linear gray scale modality, is based on the processing of higher reflected frequencies, that has improved a picture resolution, which is presented with less artifacts and limiting effects of obesity and gases. Ultrasound contrast agents improve analysis of micro and macro circulation of the examined area, and with the assessment of velocity of supply in ROI (wash in), distribution and time of signal weakening (wash out), are significantly increasing diagnostic value of ultrasound. Besides the anatomical and topographic presentation of examined region (color, power), Color Doppler sonography gives us haemodynamic-functional information on vascularisation of that region, as well as on pathologic vascularisation if present. Avascular aspect of a focal pathologic lesion corresponds to a cyst or haematoma, while coloration and positive spectral curve discover that anechogenic lesions actually represents aneurysms, pseudoaneurysms or AVF. In local inflammatory lesion, abscess in an acute phase, CDS shows first increased, and then decreased central perfusion, while in a chronic phase, a pericapsular vascularisation is present. Contribution of CDS in differentiation of hepatic tumors (hemangioma, HCC and metastasis) is very significant. Central color dots along the peripheral blood vessels and the blush phenomenon are characteristics of capillary hemangioma, peritumoral vascular ring "basket" of HCC, and "detour" sign of metastasis. The central artery, RI from 0.45 to 0.60 and radial spreading characterize FNH. Hepatic adenoma is characterized by an intratumoral vein, and rarely by a vascular hallo. Further on, blood velocity in tumor defined by Color Doppler, distinguishes malignant from benign lesion, where 40 cm/s is a

  20. Combined Scanning Transmission Electron Microscopy Tilt- and Focal Series

    SciTech Connect

    Dahmen, Tim; Baudoin, Jean-Pierre G; Lupini, Andrew R; Kubel, Christian; Slusallek, Phillip; De Jonge, Niels

    2014-01-01

    In this study, a combined tilt- and focal series is proposed as a new recording scheme for high-angle annular dark-field scanning transmission electron microscopy (STEM) tomography. Three-dimensional (3D) data were acquired by mechanically tilting the specimen, and recording a through-focal series at each tilt direction. The sample was a whole-mount macrophage cell with embedded gold nanoparticles. The tilt focal algebraic reconstruction technique (TF-ART) is introduced as a new algorithm to reconstruct tomograms from such combined tilt- and focal series. The feasibility of TF-ART was demonstrated by 3D reconstruction of the experimental 3D data. The results were compared with a conventional STEM tilt series of a similar sample. The combined tilt- and focal series led to smaller missing wedge artifacts, and a higher axial resolution than obtained for the STEM tilt series, thus improving on one of the main issues of tilt series-based electron tomography.

  1. Double peacock eye optical element for extended focal depth imaging with ophthalmic applications

    NASA Astrophysics Data System (ADS)

    Romero, Lenny A.; Millán, María S.; Jaroszewicz, Zbigniew; Kolodziejczyk, Andrzej

    2012-04-01

    The aged human eye is commonly affected by presbyopia, and therefore, it gradually loses its capability to form images of objects placed at different distances. Extended depth of focus (EDOF) imaging elements can overcome this inability, despite the introduction of a certain amount of aberration. This paper evaluates the EDOF imaging performance of the so-called peacock eye phase diffractive element, which focuses an incident plane wave into a segment of the optical axis and explores the element's potential use for ophthalmic presbyopia compensation optics. Two designs of the element are analyzed: the single peacock eye, which produces one focal segment along the axis, and the double peacock eye, which is a spatially multiplexed element that produces two focal segments with partial overlapping along the axis. The performances of the peacock eye elements are compared with those of multifocal lenses through numerical simulations as well as optical experiments in the image space. The results demonstrate that the peacock eye elements form sharper images along the focal segment than the multifocal lenses and, therefore, are more suitable for presbyopia compensation. The extreme points of the depth of field in the object space, which represent the remote and the near object points, have been experimentally obtained for both the single and the double peacock eye optical elements. The double peacock eye element has better imaging quality for relatively short and intermediate distances than the single peacock eye, whereas the latter seems better for far distance vision.

  2. Focal interictal epileptiform discharges in idiopathic generalized epilepsy.

    PubMed

    Esmail, Eman H; Nawito, Amani M; Labib, Dalia M; Basheer, Mye A

    2016-07-01

    Are idiopathic generalized epilepsies (IGEs) truly generalized? Do IGEs represent a continuum or rather distinct syndromes? Focal changes in the electroencephalography (EEG) have been reported in IGEs. The aim of this work is to investigate focal interictal epileptiform discharges (IEDs) in IGEs, and their relation to clinical variables. Forty-one IGE patients (classified according to ILAE, 2001) were recruited from a tertiary center (age 23 ± 10.938 years). Their files were reviewed and they were subjected to clinical examination and interictal EEG. Patients with focal IEDs were compared to those without focal IEDs. Nine patients had juvenile myoclonic epilepsy (JME) and 32 had idiopathic epilepsy with generalized tonic-clonic seizures only (EGTCSA). Focal IEDs were found in 20 patients, mostly in the frontal (45.5 %) and temporal (31.8 %) distribution. Patients with focal IEDs were treated with a larger number of combined antiepileptic drugs (AEDs) (p value = 0.022). No significant difference was found between the two groups regarding age, sex, age at onset, epilepsy syndrome, seizure frequency, family history, AEDs used (sodium valproate and carbamazepine) and their doses. Seventeen EGTCSA patients had focal IEDs. They were treated with larger number of combined AEDs (p value = 0.0142). No significant difference was found between the EGTCSA patients with and those without focal IEDs regarding age, sex, age at onset, seizure frequency, family history and AEDs doses. Caution must be applied in the interpretation of interictal focal IEDs. These focal changes may be related to prognosis, however this needs further investigation. PMID:26956566

  3. An empirical assessment of the focal species hypothesis.

    PubMed

    Lindenmayer, D B; Lane, P W; Westgate, M J; Crane, M; Michael, D; Okada, S; Barton, P S

    2014-12-01

    Biodiversity surrogates and indicators are commonly used in conservation management. The focal species approach (FSA) is one method for identifying biodiversity surrogates, and it is underpinned by the hypothesis that management aimed at a particular focal species will confer protection on co-occurring species. This concept has been the subject of much debate, in part because the validity of the FSA has not been subject to detailed empirical assessment of the extent to which a given focal species actually co-occurs with other species in an assemblage. To address this knowledge gap, we used large-scale, long-term data sets of temperate woodland birds to select focal species associated with threatening processes such as habitat isolation and loss of key vegetation attributes. We quantified co-occurrence patterns among focal species, species in the wider bird assemblage, and species of conservation concern. Some, but not all, focal species were associated with high levels of species richness. One of our selected focal species was negatively associated with the occurrence of other species (i.e., it was an antisurrogate)-a previously undescribed property of nominated focal species. Furthermore, combinations of focal species were not associated with substantially elevated levels of bird species richness, relative to levels associated with individual species. Our results suggest that although there is some merit to the underpinning concept of the FSA, there is also a need to ensure that actions are sufficiently flexible because management tightly focused on a given focal species may not benefit some other species, including species of conservation concern, such of which might not occur in species-rich assemblages. PMID:25048948

  4. GATOR1 complex: the common genetic actor in focal epilepsies.

    PubMed

    Baldassari, Sara; Licchetta, Laura; Tinuper, Paolo; Bisulli, Francesca; Pippucci, Tommaso

    2016-08-01

    The mammalian or mechanistic target of rapamycin (mTOR) signalling pathway has multiple roles in regulating physiology of the whole body and, particularly, the brain. Deregulation of mTOR signalling has been associated to various neurological conditions, including epilepsy. Mutations in genes encoding components of Gap Activity TOward Rags 1 (GATOR1) (DEPDC5, NPRL2 and NPRL3), a complex involved in the inhibition of the mTOR complex 1 (mTORC1), have been recently implicated in the pathogenesis of a wide spectrum of focal epilepsies (FEs), both lesional and non-lesional. The involvement of DEPDC5, NPRL2 and NRPL3 in about 10% of FEs is in contrast to the concept that specific seizure semiology points to the main involvement of a distinct brain area. The hypothesised pathogenic mechanism underlying epilepsy is the loss of the inhibitory function of GATOR1 towards mTORC1. The identification of the correct therapeutic strategy in patients with FE is challenging, especially in those with refractory epilepsy and/or malformations of cortical development (MCDs). In such cases, surgical excision of the epileptogenic zone is a curative option, although the long-term outcome is still undefined. The GATOR1/mTOR signalling represents a promising therapeutic target in FEs due to mutations in mTOR pathway genes, as in tuberous sclerosis complex, another MCD-associated epilepsy caused by mTOR signalling hyperactivation. PMID:27208208

  5. Practical Application of Columbia Classification for Focal Segmental Glomerulosclerosis

    PubMed Central

    Han, Man-Hoon; Kim, Yong-Jin

    2016-01-01

    Focal segmental glomerulosclerosis (FSGS) is a heterogeneous clinicopathological entity. Two frameworks for the classification of FSGS have been described: etiologic and morphologic. The etiologic classification is distinguished among genetic, adaptive, virus-associated, drug-induced, and idiopathic types. Morphologic classification is commonly referred to as the Columbia classification published in 2004, which distinguishes five variants: collapsing, tip, cellular, perihilar, and not otherwise specified (NOS). This classification is based on light microscopic patterns with rigorously defined specific criteria, which can be applied to primary and secondary forms of FSGS, and has been widely used over the past 10 years both as a diagnostic and as a prognostic clinical tool. This paper defines common histopathological features of FSGS, distinguished characters among five variants, and points out the confusion about terminology of variants, because most were proposed in the past with different definitions. Despite good interobserver reproducibility of this classification system, difficulty in its application may arise in the interpretation of lesions with mixed features of more than one variant in the same tissue specimen and with late lesions, because other variants may evolve into the NOS variant over time. PMID:27247945

  6. Tipping Point

    MedlinePlus Videos and Cool Tools

    ... Tipping Point by CPSC Blogger September 22 appliance child Childproofing CPSC danger death electrical fall furniture head ... TV falls with about the same force as child falling from the third story of a building. ...

  7. Tohoku University Focal Plane Array Controller (TUFPAC)

    NASA Astrophysics Data System (ADS)

    Ichikawa, Takashi; Matsumoto, Daigo; Yanagisawa, Kenshi; Katsuno, Yuka; Suzuki, Ryuji; Tokoku, Chihiro; Asai, Ken'ichiro; Nishimura, Tetsuo

    2003-03-01

    TUFPAC (Tohoku University Focal Plane Array Controller) is an array control system originally designed for flexible control and efficient data acquisition of 2048 x 2048 HgCdTe (HAWAII-2) array. A personal computer operated by Linux OS controls mosaic HAWAII-2s with commercially available DSP boards installed on the PCI bus. Triggered by PC, DSP sends clock data to front-end electronics, which is isolated from the DSP board by photo-couplers. Front-end electronics supply powers, biases and clock signals to HAWAII2. Pixel data are read from four outputs of each HAWAII2 simultaneously by way of four channel preamps and ADCs. Pixel data converted to 16 bit digital data are stored in the frame memory on the DSP board. Data are processed in the memory when necessary. PC receives the frame data and stores it in the hard disk of PC in FITS format. A set of the DSP board and front-end electronics is responsible for controlling each HAWAII-2. One PC can operate eight mosaic arrays at most. TUFPAC is applicable to the control of CCDs with minor changes of front-end electronics.

  8. Focal Plane Arrays and Electronics for WISE

    NASA Astrophysics Data System (ADS)

    Masterjohn, Stacy; Hogue, H.; Mattson, R.; Dawson, L.; Bojorquez, A.; Muzilla, M.

    2009-01-01

    DRS provided the four channel focal plane array system for the Wide-field Infrared Survey Explorer (WISE) payload. The two shorter wavelength bands, centered near 3.2 and 4.5 µm, employed 1024x1024 HAWAII 1RG Mercury Cadmium Telluride (MCT) FPAs obtained from Teledyne Imaging Systems, Inc. The two longer wavelength bands, centered near 12 and 24 µm, utilized 1024x1024 arsenic doped silicon (Si:As) Blocked Impurity Band (BIB) FPAs, which were developed for the program by DRS. DRS packaged the 4 FPAs into similar custom cryogenic modules, each with its own flexible cryogenic ribbon cable to route FPA image output signals from within the WISE cryogenic telescope assembly through the cryostat walls. DRS also designed the cables and a common flight electronics box (FEB) to operate all 4 FPAs to provide their multiplexed digital image data streams to subsequent on-payload data processing and downlink systems. Fully functional, non-flight versions of the cabling and FEB were built to operate the FPAs during payload integration. The FPA system was delivered to the WISE payload integrator Space Dynamics Laboratory (SDL) in late 2007, and it is currently being integrated in to the WISE payload.

  9. SOI diode uncooled infrared focal plane arrays

    NASA Astrophysics Data System (ADS)

    Kimata, Masafumi; Ueno, Masashi; Takeda, Munehisa; Seto, Toshiki

    2006-02-01

    An uncooled infrared focal plane array (IR FPA) is a MEMS device that integrates an array of tiny thermal infrared detector pixels. An SOI diode uncooled IR FPA is a type that uses freestanding single-crystal diodes as temperature sensors and has various advantages over the other MEMS-based uncooled IR FPAs. Since the first demonstration of an SOI diode uncooled IR FPA in 1999, the pixel structure has been improved by developing sophisticated MEMS processes. The most advanced pixel has a three-level structure that has an independent metal reflector for interference infrared absorption between the temperature sensor (bottom level) and the infrared-absorbing thin metal film (top level). This structure makes it possible to design pixels with lower thermal conductance by allocating more area for thermal isolation without reducing infrared absorption. The new MEMS process for the three-level structure includes a XeF II dry bulk silicon etching process and a double organic sacrificial layer surface micromachining process. Employing advanced MEMS technology, we have developed a 640 x 480-element SOI diode uncooled IR FPA with 25-μm square pixels. The noise equivalent temperature difference of the FPA is 40 mK with f/1.0 optics. This result clearly demonstrates the great potential of the SOI diode uncooled IR FPA for high-end applications. In this paper, we explain the advances and state-of-the-art technology of the SOI diode uncooled IR FPA.

  10. PATHOGENETIC MECHANISMS OF FOCAL CORTICAL DYSPLASIA

    PubMed Central

    Marin-Valencia, Isaac; Guerrini, Renzo; Gleeson, Joseph G.

    2014-01-01

    SUMMARY Objective Focal cortical dysplasias (FCDs) constitute a prevalent cause of intractable epilepsy in children, and one of the leading conditions requiring epilepsy surgery. Despite the recent advances on the cellular and molecular biology of these conditions, the pathogenetic mechanisms of FCDs remain largely unknown. The purpose if this work is to review the molecular underpinnings of FCDs and to highlight potential therapeutic targets. Methods A systematic review of the literature regarding the histological, molecular, and electrophysiological aspects of FCDs was conducted. Results Disruption of the mTOR signaling comprises a common pathway underlying the structural and electrical disturbances of some FCDs. Other mechanisms such as viral infections, prematurity, head trauma, and brain tumors are also posited. mTOR inhibitors (i.e., rapamycin) have shown positive results on seizure management in animal models and in a small cohort of patients with FCD. Significance Encouraging progresses have been achieved on the molecular and electrophysiological basis of constitutive cells in the dysplastic tissue. Despite the promising results of mTOR inhibitors, large-scale randomized trials are in need to evaluate their efficacy and side effects, along with additional mechanistic studies for the development of novel, molecular-based diagnostic and therapeutic approaches. PMID:24861491

  11. Dynamic MEG imaging of focal neuronal sources

    SciTech Connect

    Phillips, J.W.; Leahy R.M.; Mosher, J.C.

    1996-12-31

    We describe inverse methods for using the magnetoencephalogram (MEG) to image neural current sources associated with functional activation in the cerebral cortex. A Bayesian formulation is presented that is based on a Gibbs prior which reflects the sparse, focal nature of neural activation. The model includes a dynamic component so that we can utilize the full spatio-temporal data record to reconstruct a sequence of images reflecting changes in the current source amplitudes during activation. The model consists of the product of a binary field, representing the areas of activation in the cerebral cortex, and a time series at each site which represents the dynamic changes in the source amplitudes at the active sites. Our estimation methods are based on the optimization of three different functions of the posterior density. Each of these methods requires the estimation of a binary field which we compute using a mean field annealing method. We demonstrate and compare our methods in application to computer generated and experimental phantom data.

  12. Terahertz detectors and focal plane arrays

    NASA Astrophysics Data System (ADS)

    Rogalski, A.; Sizov, F.

    2011-09-01

    Terahertz (THz) technology is one of emerging technologies that will change our life. A lot of attractive applications in security, medicine, biology, astronomy, and non-destructive materials testing have been demonstrated already. However, the realization of THz emitters and receivers is a challenge because the frequencies are too high for conventional electronics and the photon energies are too small for classical optics. As a result, THz radiation is resistant to the techniques commonly employed in these well established neighbouring bands. In the paper, issues associated with the development and exploitation of THz radiation detectors and focal plane arrays are discussed. Historical impressive progress in THz detector sensitivity in a period of more than half century is analyzed. More attention is put on the basic physical phenomena and the recent progress in both direct and heterodyne detectors. After short description of general classification of THz detectors, more details concern Schottky barrier diodes, pair braking detectors, hot electron mixers and field-effect transistor detectors, where links between THz devices and modern technologies such as micromachining are underlined. Also, the operational conditions of THz detectors and their upper performance limits are reviewed. Finally, recent advances in novel nanoelectronic materials and technologies are described. It is expected that applications of nanoscale materials and devices will open the door for further performance improvement in THz detectors.

  13. Digital-pixel focal plane array development

    NASA Astrophysics Data System (ADS)

    Brown, Matthew G.; Baker, Justin; Colonero, Curtis; Costa, Joe; Gardner, Tom; Kelly, Mike; Schultz, Ken; Tyrrell, Brian; Wey, Jim

    2010-01-01

    Since 2006, MIT Lincoln Laboratory has been developing Digital-pixel Focal Plane Array (DFPA) readout integrated circuits (ROICs). To date, four 256 × 256 30 μm pitch DFPA designs with in-pixel analog to digital conversion have been fabricated using IBM 90 nm CMOS processes. The DFPA ROICs are compatible with a wide range of detector materials and cutoff wavelengths; HgCdTe, QWIP, and InGaAs photo-detectors with cutoff wavelengths ranging from 1.6 to 14.5 μm have been hybridized to the same digital-pixel readout. The digital-pixel readout architecture offers high dynamic range, A/C or D/C coupled integration, and on-chip image processing with low power orthogonal transfer operations. The newest ROIC designs support two-color operation with a single Indium bump connection. Development and characterization of the two-color DFPA designs is presented along with applications for this new digital readout technology.

  14. Recurrent focal segmental glomerulosclerosis after kidney transplantation.

    PubMed

    Trachtman, Rebecca; Sran, Simranjeet S; Trachtman, Howard

    2015-10-01

    Focal segmental glomerulosclerosis (FSGS) is an important cause of glomerular disease in children and adolescents and nearly 50 % of affected patients will progress to end-stage kidney disease over a 5 to 10-year period. Unfortunately, there is no established treatment for disease in the native kidney. Moreover, up to 55 % of patients develop recurrent disease after receiving a kidney transplant, with a substantially higher risk in patients who have already experienced recurrent disease in a prior transplant. A number of clinical and laboratory factors have been identified as risk factors for this complication. In addition, new investigations into podocyte biology and circulating permeability factors have shed light on the cause of recurrent the disease. While a number of novel therapeutic agents have been applied in the management of this problem, there still is no proven treatment. In this review, we summarize recent advances in the epidemiology, pathophysiology, and treatment of recurrent FSGS in pediatric patients who have received a kidney transplant. PMID:25690943

  15. Focal cooling rapidly terminates experimental neocortical seizures.

    PubMed

    Yang, X F; Rothman, S M

    2001-06-01

    The efficacy of surgical resection for epilepsy is considerably lower for neocortical epilepsy than for temporal lobe epilepsy. We have explored focal cooling with a thermoelectric (Peltier) device as a potential therapy for neocortical epilepsy. After creating a cranial window in anesthetized rats, we induced seizures by injecting artificial cerebrospinal fluid containing 4-aminopyridine (4-AP), a potassium channel blocker. Within 30 minutes of 4-AP injection, animals developed recurrent seizures (duration 85.7 +/- 26.2 seconds; n = 10 rats) that persisted for 2 hours. When a small Peltier device cooled the exposed cortical surface to 20-25 degrees C at seizure onset, the seizure duration was reduced to 8.4 +/- 5.0 seconds (n = 10 rats; p < 0.001). When the Peltier device was placed close to the cortical surface, but not allowed to make physical contact, there was no effect on seizure duration (104.3 +/- 20.7 seconds; p > 0.05 compared to control). Interestingly, the duration of uncooled seizures was reduced after we allowed the cortex to rewarm from prior cooling. Histological examination of the cortex after cooling has shown no evidence of acute or delayed neuronal injury, and blood pressure and temperature remained stable. It may be possible to use Peltier devices for cortical mapping or, when seizure detection algorithms improve, for chronic seizure control. PMID:11409423

  16. Multiwavelength infrared focal plane array detector

    NASA Technical Reports Server (NTRS)

    Forrest, Stephen R. (Inventor); Olsen, Gregory H. (Inventor); Kim, Dong-Su (Inventor); Lange, Michael J. (Inventor)

    1995-01-01

    A multiwavelength focal plane array infrared detector is included on a common substrate having formed on its top face a plurality of In.sub.x Ga.sub.1-x As (x.ltoreq.0.53) absorption layers, between each pair of which a plurality of InAs.sub.y P.sub.1-y (y<1) buffer layers are formed having substantially increasing lattice parameters, respectively, relative to said substrate, for preventing lattice mismatch dislocations from propagating through successive ones of the absorption layers of decreasing bandgap relative to said substrate, whereby a plurality of detectors for detecting different wavelengths of light for a given pixel are provided by removing material above given areas of successive ones of the absorption layers, which areas are doped to form a pn junction with the surrounding unexposed portions of associated absorption layers, respectively, with metal contacts being formed on a portion of each of the exposed areas, and on the bottom of the substrate for facilitating electrical connections thereto.

  17. Imaging performance and modeling of the Infrared Multi-Object Spectrometer focal reducer

    NASA Astrophysics Data System (ADS)

    Connelly, Joseph A.; Ohl, Raymond G., IV; Saha, Timo T.; Hadjimichael, Theo; Mentzell, John E.; Mink, Ronald G.; Hylan, Jason E.; Sparr, Leroy M.; Chambers, John; Hagopian, John J.; Greenhouse, Matthew A.; Winsor, Robert S.; MacKenty, John W.

    2003-03-01

    The Infrared Multi-Object Spectrometer (IRMOS) is a facility instrument for the Kitt Peak National Observatory 4 and 2.1 meter telescopes. IRMOS is a near-IR (0.8 2.5 μm) spectrometer with low- to mid-resolving power (R = 300 3000). The IRMOS spectrometer produces simultaneous spectra of ~100 objects in its 2.8 x 2.0 arcmin field of view using a commercial MEMS multi-mirror array device (MMA) from Texas Instruments. The IRMOS optical design consists of two imaging subsystems. The focal reducer images the focal plane of the telescope onto the MMA field stop, and the spectrograph images the MMA onto the detector. We describe the breadboard subsystem alignment method and imaging performance of the focal reducer. This testing provides verification of the optomechanical alignment method and a measurement of near-angle scattered light due to mirror small-scale surface error. Interferometric measurements of subsystem wavefront error serve to verify alignment and are accomplished using a commercial, modified Twyman-Green laser unequal path interferometer. Image testing is then performed for the central field point. A mercury-argon pencil lamp provides the spectral line at 546.1 nm, and a CCD camera is the detector. We use the Optical Surface Analysis Code to predict the point-spread function and its effect on instrument slit transmission, and our breadboard test results validate this prediction. Our results show that scattered light from the subsystem and encircled energy is slightly worse than expected. Finally, we perform component level image testing of the MMA, and our results show that scattered light from the MMA is of the same magnitude as that of the focal reducer.

  18. Evaluation of focal fields and radiation characteristics of a dual-offset reflector antenna

    NASA Astrophysics Data System (ADS)

    Bird, T. S.; Boomars, J. L.

    1980-08-01

    A receive-mode analysis of a dual-offset reflector antenna consisting of an offset paraboloid and an offset hyperboloid is presented. In this analysis the field scattered from the offset paraboloid is determined using a GTD formulation involving two edge points and a reflection point, if one exists. A method is described for deciding whether there is a reflection point from the gradient of the path length at the edge points. The focal-region fields and the radiation characteristics are computed by numerical integration of the physical optics current on the offset hyperboloid. An experimental antenna operating at 35 GHz is described. Results of measurements of radiation patterns and of the power coupled into a circular waveguide array feed are compared with theory. In each case reasonable agreement is achieved for copolarized directed components. However, the experimental antenna produced higher crosspolarization than expected.

  19. The dispersion-focalization theory of sound systems

    NASA Astrophysics Data System (ADS)

    Schwartz, Jean-Luc; Abry, Christian; Boë, Louis-Jean; Vallée, Nathalie; Ménard, Lucie

    2005-04-01

    The Dispersion-Focalization Theory states that sound systems in human languages are shaped by two major perceptual constraints: dispersion driving auditory contrast towards maximal or sufficient values [B. Lindblom, J. Phonetics 18, 135-152 (1990)] and focalization driving auditory spectra towards patterns with close neighboring formants. Dispersion is computed from the sum of the inverse squared inter-spectra distances in the (F1, F2, F3, F4) space, using a non-linear process based on the 3.5 Bark critical distance to estimate F2'. Focalization is based on the idea that close neighboring formants produce vowel spectra with marked peaks, easier to process and memorize in the auditory system. Evidence for increased stability of focal vowels in short-term memory was provided in a discrimination experiment on adult French subjects [J. L. Schwartz and P. Escudier, Speech Comm. 8, 235-259 (1989)]. A reanalysis of infant discrimination data shows that focalization could well be the responsible for recurrent discrimination asymmetries [J. L. Schwartz et al., Speech Comm. (in press)]. Recent data about children vowel production indicate that focalization seems to be part of the perceptual templates driving speech development. The Dispersion-Focalization Theory produces valid predictions for both vowel and consonant systems, in relation with available databases of human languages inventories.

  20. Focal Length Affects Depicted Shape and Perception of Facial Images

    PubMed Central

    Třebický, Vít; Fialová, Jitka; Kleisner, Karel; Havlíček, Jan

    2016-01-01

    Static photographs are currently the most often employed stimuli in research on social perception. The method of photograph acquisition might affect the depicted subject’s facial appearance and thus also the impression of such stimuli. An important factor influencing the resulting photograph is focal length, as different focal lengths produce various levels of image distortion. Here we tested whether different focal lengths (50, 85, 105 mm) affect depicted shape and perception of female and male faces. We collected three portrait photographs of 45 (22 females, 23 males) participants under standardized conditions and camera setting varying only in the focal length. Subsequently, the three photographs from each individual were shown on screen in a randomized order using a 3-alternative forced-choice paradigm. The images were judged for attractiveness, dominance, and femininity/masculinity by 369 raters (193 females, 176 males). Facial width-to-height ratio (fWHR) was measured from each photograph and overall facial shape was analysed employing geometric morphometric methods (GMM). Our results showed that photographs taken with 50 mm focal length were rated as significantly less feminine/masculine, attractive, and dominant compared to the images taken with longer focal lengths. Further, shorter focal lengths produced faces with smaller fWHR. Subsequent GMM revealed focal length significantly affected overall facial shape of the photographed subjects. Thus methodology of photograph acquisition, focal length in this case, can significantly affect results of studies using photographic stimuli perhaps due to different levels of perspective distortion that influence shapes and proportions of morphological traits. PMID:26894832

  1. Focal spot measurements using a digital flat panel detector

    PubMed Central

    Jain, Amit; Panse, A.; Bednarek, Daniel R.; Rudin, Stephen

    2014-01-01

    Focal spot size is one of the crucial factors that affect the image quality of any x-ray imaging system. It is, therefore, important to measure the focal spot size accurately. In the past, pinhole and slit measurements of x-ray focal spots were obtained using direct exposure film. At present, digital detectors are replacing film in medical imaging so that, although focal spot measurements can be made quickly with such detectors, one must be careful to account for the generally poorer spatial resolution of the detector and the limited usable magnification. For this study, the focal spots of a diagnostic x-ray tube were measured with a 10-μm pinhole using a 194-μm pixel flat panel detector (FPD). The two-dimensional MTF, measured with the Noise Response (NR) Method was used for the correction for the detector blurring. The resulting focal spot sizes based on the FWTM (Full Width at Tenth Maxima) were compared with those obtained with a very high resolution detector with 8-μm pixels. This study demonstrates the possible effect of detector blurring on the focal spot size measurements with digital detectors with poor resolution and the improvement obtained by deconvolution. Additionally, using the NR method for measuring the two-dimensional MTF, any non-isotropies in detector resolution can be accurately corrected for, enabling routine measurement of non-isotropic x-ray focal spots. This work presents a simple, accurate and quick quality assurance procedure for measurements of both digital detector properties and x-ray focal spot size and distribution in modern x-ray imaging systems. PMID:25302004

  2. Focal Length Affects Depicted Shape and Perception of Facial Images.

    PubMed

    Třebický, Vít; Fialová, Jitka; Kleisner, Karel; Havlíček, Jan

    2016-01-01

    Static photographs are currently the most often employed stimuli in research on social perception. The method of photograph acquisition might affect the depicted subject's facial appearance and thus also the impression of such stimuli. An important factor influencing the resulting photograph is focal length, as different focal lengths produce various levels of image distortion. Here we tested whether different focal lengths (50, 85, 105 mm) affect depicted shape and perception of female and male faces. We collected three portrait photographs of 45 (22 females, 23 males) participants under standardized conditions and camera setting varying only in the focal length. Subsequently, the three photographs from each individual were shown on screen in a randomized order using a 3-alternative forced-choice paradigm. The images were judged for attractiveness, dominance, and femininity/masculinity by 369 raters (193 females, 176 males). Facial width-to-height ratio (fWHR) was measured from each photograph and overall facial shape was analysed employing geometric morphometric methods (GMM). Our results showed that photographs taken with 50 mm focal length were rated as significantly less feminine/masculine, attractive, and dominant compared to the images taken with longer focal lengths. Further, shorter focal lengths produced faces with smaller fWHR. Subsequent GMM revealed focal length significantly affected overall facial shape of the photographed subjects. Thus methodology of photograph acquisition, focal length in this case, can significantly affect results of studies using photographic stimuli perhaps due to different levels of perspective distortion that influence shapes and proportions of morphological traits. PMID:26894832

  3. Deep ultraviolet (254 nm) focal plane array

    NASA Astrophysics Data System (ADS)

    Cicek, Erdem; Vashaei, Zahra; McClintock, Ryan; Razeghi, Manijeh

    2011-10-01

    We report the synthesis, fabrication and testing of a 320 × 256 focal plane array (FPA) of back-illuminated, solarblind, p-i-n, AlxGa1-xN-based detectors, fully realized within our research laboratory. We implemented a novel pulsed atomic layer deposition technique for the metalorganic chemical vapor deposition (MOCVD) growth of crackfree, thick, and high Al composition AlxGa1-xN layers. Following the growth, the wafer was processed into a 320 × 256 array of 25 μm × 25 μm pixels on a 30 μm pixel-pitch and surrounding mini-arrays. A diagnostic mini-array was hybridized to a silicon fan-out chip to allow the study of electrical and optical characteristics of discrete pixels of the FPA. At a reverse bias of 1 V, an average photodetector exhibited a low dark current density of 1.12×10-8 A/cm2. Solar-blind operation is observed throughout the array with peak detection occurring at wavelengths of 256 nm and lower and falling off three orders of magnitude by 285 nm. After indium bump deposition and dicing, the FPA is hybridized to a matching ISC 9809 readout integrated circuit (ROIC). By developing a novel masking technology, we significantly reduced the visible response of the ROIC and thus the need for external filtering to achieve solar- and visible-blind operation is eliminated. This allowed the FPA to achieve high external quantum efficiency (EQE): at 254 nm, average pixels showed unbiased peak responsivity of 75 mA/W, which corresponds to an EQE of ~37%. Finally, the uniformity of the FPA and imaging properties are investigated.

  4. Controlling the thermally induced focal shift in laser processing heads

    NASA Astrophysics Data System (ADS)

    Negel, Jan-Philipp; Abt, Felix; Blázquez-Sánchez, David; Austerschulte, Armin; Hafner, Margit; Liebig, Thomas; von Strobl-Albeg, Philipp; Weber, Rudolf; Abdou Ahmed, Marwan; Voss, Andreas; Graf, Thomas

    2012-03-01

    A system being able to in situ measure and control not simply the distance between the workpiece and the focusing optics, but the true focal position on the workpiece including the thermally induced focal shift in a laser processing head is presented. In order to achieve this, a bundle of astigmatic measurement beams is used following the same optical path as the welding beam. A camera and a software algorithm allow to keep the focal position constant within a range of 4 mm and with a resolution between 150 μm and 500 μm.

  5. Scanning Characteristics of Metamirror Antennas With Subwavelength Focal Distance

    NASA Astrophysics Data System (ADS)

    Tcvetkova, Svetlana N.; Asadchy, Viktar S.; Tretyakov, Sergei A.

    2016-08-01

    We investigate beam scanning by lateral feed displacement in novel metasurface based reflector antennas with extremely short focal distances. Electric field distributions of the waves reflected from the antenna are studied numerically and experimentally for defocusing angles up to 24 degrees. The results show that despite extremely small focal distances, the scanning ability of metamirrors is similar to that of comparable reflectarrays. In addition to offering a possibility to realize extremely small focal distances, metamirror antennas are practically penetrable and invisible for any radiation outside of the operating frequency range.

  6. Microlenses with focal length controlled by chemical processes

    NASA Astrophysics Data System (ADS)

    Muric, B. D.; Panic, B. M.

    2012-05-01

    The influence of chemical processing on the optical properties of microlenses formed on a gelatin-sensitized layer was investigated. The gelatin is sensitized with tot'hema and eosin, irradiated with a Gaussian profile laser beam and subsequently chemically processed. Microlenses with a focal length of 400 μm were obtained after alcohol processing. Additionally, focal lengths could be controlled by varying the alum concentration, and lenses with focal length up to 1.2 mm were obtained. The microlenses become stable after alum processing. Their optical properties remain unchanged.

  7. MWIR and LWIR Megapixel QWIP Focal Plane Arrays

    NASA Technical Reports Server (NTRS)

    Gunapala, Sarath D.; Bandara, S. V.; Liu, J. K.; Rafol, S. B.; Thang, J.; Mumolo, Jason; Tidrow, M.; LeVan, P. D.; Hill, C.

    2004-01-01

    A mid-wavelength infrared (MWIR) and long-wavelength infrared (LWIR) 1024x1024 pixel quantum well infrared photodetector (QWIP) focal plane array has been demonstrated with excellent imagery. MWIR focal plane has given noise equivalent differential temperature (NETD) of 19 mK at 95K operating temperature with f/2.5 optics at 300K background and LWIR focal plane has given NEDT of 13 mK at 70K operating temperature with same optical and background conditions as MWIR array. Both of these focal plane arrays have shown background limited performance (BLIP) at 90K and 70K operating temperatures with the same optics and background conditions. In this paper, we will discuss their performance in quantum efficiency, NETD, uniformity, and operability.

  8. Creation of identical multiple focal spots with prescribed axial distribution

    NASA Astrophysics Data System (ADS)

    Yu, Yanzhong; Zhan, Qiwen

    2015-10-01

    We present a scheme for the construction of coaxially equidistant multiple focal spots with identical intensity profiles for each individual focus and a predetermined number and spacing. To achieve this, the radiation field from an antenna is reversed and then gathered by high numerical aperture objective lenses. Radiation patterns from three types of line sources, i.e., the electric current, magnetic current and electromagnetic current distributions, with cosine-squared taper are respectively employed to generate predominately longitudinally polarized bright spots, azimuthally polarized doughnuts, and focal spots with a perfect spherically symmetric intensity distribution. The required illuminations at the pupil plane of a 4Pi focusing configuration for the creation of these identical multiple focal spots can be easily derived by solving the inverse problem of the antenna radiation field. These unique focal field distributions may find potential applications in laser direct writing and optical microscopy, as well as multiple-particle trapping, alignment, and acceleration along the optical axis.

  9. Real-time focal stack compositing for handheld mobile cameras

    NASA Astrophysics Data System (ADS)

    Solh, Mashhour

    2013-03-01

    Extending the depth of field using a single lens camera on a mobile device can be achieved by capturing a set of images each focused at a different depth or focal stack then combine these samples of the focal stack to form a single all-in-focus image or an image refocused at a desired depth of field. Focal stack compositing in real time for a handheld mobile camera has many challenges including capturing, processing power, handshaking, rolling shutter artifacts, occlusion, and lens zoom effect. In this paper, we describe a system for a real time focal stack compositing system for handheld mobile device with an alignment and compositing algorithms. We will also show all-in-focus images captured and processed by a cell phone camera running on Android OS.

  10. Perverted head shaking nystagmus in focal pontine infarction.

    PubMed

    Kim, Hyun-Ah; Lee, Hyung; Sohn, Sung-Il; Kim, Ji Soo; Baloh, Robert W

    2011-02-15

    Although several papers have been published on perverted head shaking nystagmus (PHSN) associated with focal brainstem or cerebellar lesion, there are no reports of a focal pontine infarct that causes PHSN. We report a patient with focal pontine infarction who presented with sustained dizziness, limb dysmetria on the left extremity, decreased sensations to position and vibration of the left extremity, and gait imbalance. Only vestibular abnormality was downbeat nystagmus after vigorous head shakings. The maximum slow phase velocity of PHSN was 26°/s, and its duration was about 20s. This is the first report of PHSN associated with focal pontine infarction. Crossed ventral tegmental tract and velocity storage mechanism of vestibulocerebellum might be related on PHSN in this case. PMID:21146834

  11. Oral focal mucinosis: a rare case with literature review.

    PubMed

    Sowmya, G V; Manjunatha, Bhari Sharanesha; Nahar, Prashant; Aggarwal, Hersheal

    2015-01-01

    Oral focal mucinosis (OFM) is an unusual disease that affects diverse localised areas of the mouth, where the connective tissue undergoes focal degeneration. It was described for the first time by Tomich in 1974. It presents as an asymptomatic pedunculated or sessile growth, commonly on the gingiva, with most cases being in women. Its pathogenesis is linked to overproduction of hyaluronic acid by fibroblasts during collagen production, ensuing in focal myxoid degeneration. It has no characteristic features and diagnosis depends on histological scrutiny. We report a rare case of oral focal mucinosis affecting a 54-year-old man who presented with a sessile gingival growth mimicking a common tumour-like lesion. PMID:25759271

  12. Focal Therapy of Prostate Cancer Using Irreversible Electroporation.

    PubMed

    Valerio, Massimo; Ahmed, Hashim U; Emberton, Mark

    2015-09-01

    Focal therapy is a novel strategy that attempts to enhance the therapeutic ratio of standard radical treatment in prostate cancer. Irreversible electroporation (IRE) has some inherent characteristics that may be ideal for focal therapy. Precise confined ablation in the treatment area obtained via nonthermal damage with potential for minimal toxicity to surrounding structures may lead to optimal treatment with improved preservation of continence and erectile function. Initial data of focal IRE of the prostate are encouraging although further assessment is awaited to confirm these findings using robust methodology. In this article, we provide a comprehensive step-by-step description of our technique to deliver focal IRE in selected men with localized prostate cancer located in a discrete area of the prostate. PMID:26365544

  13. Creation of identical multiple focal spots with prescribed axial distribution

    PubMed Central

    Yu, Yanzhong; Zhan, Qiwen

    2015-01-01

    We present a scheme for the construction of coaxially equidistant multiple focal spots with identical intensity profiles for each individual focus and a predetermined number and spacing. To achieve this, the radiation field from an antenna is reversed and then gathered by high numerical aperture objective lenses. Radiation patterns from three types of line sources, i.e., the electric current, magnetic current and electromagnetic current distributions, with cosine-squared taper are respectively employed to generate predominately longitudinally polarized bright spots, azimuthally polarized doughnuts, and focal spots with a perfect spherically symmetric intensity distribution. The required illuminations at the pupil plane of a 4Pi focusing configuration for the creation of these identical multiple focal spots can be easily derived by solving the inverse problem of the antenna radiation field. These unique focal field distributions may find potential applications in laser direct writing and optical microscopy, as well as multiple-particle trapping, alignment, and acceleration along the optical axis. PMID:26424051

  14. Levetiracetam in focal epilepsy and hepatic porphyria: a case report.

    PubMed

    Paul, Friedemann; Meencke, Heinz-Joachim

    2004-05-01

    We report a patient with focal epilepsy and latent hereditary coproporphyria who had exacerbation of clinical symptoms of porphyria under treatment with valproate and primidone and was then treated with levetiracetam without exacerbation of clinically latent porphyria. PMID:15101839

  15. Compact Focal Plane Assembly for Planetary Science

    NASA Technical Reports Server (NTRS)

    Brown, Ari; Aslam, Shahid; Huang, Wei-Chung; Steptoe-Jackson, Rosalind

    2013-01-01

    A compact radiometric focal plane assembly (FPA) has been designed in which the filters are individually co-registered over compact thermopile pixels. This allows for construction of an ultralightweight and compact radiometric instrument. The FPA also incorporates micromachined baffles in order to mitigate crosstalk and low-pass filter windows in order to eliminate high-frequency radiation. Compact metal mesh bandpass filters were fabricated for the far infrared (FIR) spectral range (17 to 100 microns), a game-changing technology for future planetary FIR instruments. This fabrication approach allows the dimensions of individual metal mesh filters to be tailored with better than 10- micron precision. In contrast, conventional compact filters employed in recent missions and in near-term instruments consist of large filter sheets manually cut into much smaller pieces, which is a much less precise and much more labor-intensive, expensive, and difficult process. Filter performance was validated by integrating them with thermopile arrays. Demonstration of the FPA will require the integration of two technologies. The first technology is compact, lightweight, robust against cryogenic thermal cycling, and radiation-hard micromachined bandpass filters. They consist of a copper mesh supported on a deep reactive ion-etched silicon frame. This design architecture is advantageous when constructing a lightweight and compact instrument because (1) the frame acts like a jig and facilitates filter integration with the FPA, (2) the frame can be designed so as to maximize the FPA field of view, (3) the frame can be simultaneously used as a baffle for mitigating crosstalk, and (4) micron-scale alignment features can be patterned so as to permit high-precision filter stacking and, consequently, increase the filter bandwidth and sharpen the out-of-band rolloff. The second technology consists of leveraging, from another project, compact and lightweight Bi0.87Sb0.13/Sb arrayed thermopiles

  16. Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

    PubMed Central

    Bouchet, Benjamin P; Gough, Rosemarie E; Ammon, York-Christoph; van de Willige, Dieudonnée; Post, Harm; Jacquemet, Guillaume; Altelaar, AF Maarten; Heck, Albert JR; Goult, Benjamin T; Akhmanova, Anna

    2016-01-01

    The cross-talk between dynamic microtubules and integrin-based adhesions to the extracellular matrix plays a crucial role in cell polarity and migration. Microtubules regulate the turnover of adhesion sites, and, in turn, focal adhesions promote the cortical microtubule capture and stabilization in their vicinity, but the underlying mechanism is unknown. Here, we show that cortical microtubule stabilization sites containing CLASPs, KIF21A, LL5β and liprins are recruited to focal adhesions by the adaptor protein KANK1, which directly interacts with the major adhesion component, talin. Structural studies showed that the conserved KN domain in KANK1 binds to the talin rod domain R7. Perturbation of this interaction, including a single point mutation in talin, which disrupts KANK1 binding but not the talin function in adhesion, abrogates the association of microtubule-stabilizing complexes with focal adhesions. We propose that the talin-KANK1 interaction links the two macromolecular assemblies that control cortical attachment of actin fibers and microtubules. DOI: http://dx.doi.org/10.7554/eLife.18124.001 PMID:27410476

  17. Penalized maximum-likelihood sinogram restoration for dual focal spot computed tomography.

    PubMed

    Forthmann, P; Köhler, T; Begemann, P G C; Defrise, M

    2007-08-01

    Due to various system non-idealities, the raw data generated by a computed tomography (CT) machine are not readily usable for reconstruction. Although the deterministic nature of corruption effects such as crosstalk and afterglow permits correction by deconvolution, there is a drawback because deconvolution usually amplifies noise. Methods that perform raw data correction combined with noise suppression are commonly termed sinogram restoration methods. The need for sinogram restoration arises, for example, when photon counts are low and non-statistical reconstruction algorithms such as filtered backprojection are used. Many modern CT machines offer a dual focal spot (DFS) mode, which serves the goal of increased radial sampling by alternating the focal spot between two positions on the anode plate during the scan. Although the focal spot mode does not play a role with respect to how the data are affected by the above-mentioned corruption effects, it needs to be taken into account if regularized sinogram restoration is to be applied to the data. This work points out the subtle difference in processing that sinogram restoration for DFS requires, how it is correctly employed within the penalized maximum-likelihood sinogram restoration algorithm and what impact it has on image quality. PMID:17634647

  18. Effects of glucocorticoid treatment on focal and systemic bone loss in rheumatoid arthritis.

    PubMed

    Di Munno, O; Delle Sedie, A

    2008-07-01

    Rheumatoid arthritis (RA) is characterized by an extensive dysregulation in skeletal homeostasis recognized as 1) focal articular bone erosions, 2) iuxta-articular osteopenia, 3) systemic osteoporosis (OP) and fractures, as is well documented in both cross-sectional and prospective studies. The disease activity, as a consequence of new insights into the complex interaction between bone cells and a variety of cells of the immune system, has emerged as the main responsible for both focal and systemic bone loss. Given this background, the therapeutic approach to RA has become more aggressive, and a more widespread use of low-dose glucocorticoids (GC), recently categorized as disease modifying antirheumatic drugs (DMARD) because of their additional joint sparing effect on the long-term, has also been recommended from the early stages. Addressing the effects of GC on systemic bone loss in RA, GC are considered, in addition to inflammation and inactivity, the major risk factors for OP and fractures. As a consequence, among the most recent recommendations (i.e. dosing, timing, and tapering strategies) for patients receiving GC for more than 3 months, prevention and treatment of GC-induced OP (i.e. calcium, vitamin D, and bisphosphonates) are included. However, innovative GC, characterized by a more favorable risk/benefit profile such as selective GC receptor agonists (SEGRA), are currently in the pipeline. This article reviews the major points of evidence so far available, regarding the effects of GC on focal and systemic bone loss. PMID:18791351

  19. Drug and light dose responses to focal photodynamic therapy of single blood vessels in vivo

    NASA Astrophysics Data System (ADS)

    Khurana, Mamta; Moriyama, Eduardo H.; Mariampillai, Adrian; Samkoe, Kimberley; Cramb, David; Wilson, Brian C.

    2009-11-01

    As part of an ongoing program to develop two-photon (2-γ) photodynamic therapy (PDT) for treatment of wet-form age-related macular degeneration (AMD) and other vascular pathologies, we have evaluated the reciprocity of drug-light doses in focal-PDT. We targeted individual arteries in a murine window chamber model, using primarily the clinical photosensitizer Visudyne/liposomal-verteporfin. Shortly after administration of the photosensitizer, a small region including an arteriole was selected and irradiated with varying light doses. Targeted and nearby vessels were observed for a maximum of 17 to 25 h to assess vascular shutdown, tapering, and dye leakage/occlusion. For a given end-point metric, there was reciprocity between the drug and light doses, i.e., the response correlated with the drug-light product (DLP). These results provide the first quantification of photosensitizer and light dose relationships for localized irradiation of a single blood vessel and are compared to the DLP required for vessel closure between 1-γ and 2-γ activation, between focal and broad-beam irradiation, and between verteporfin and a porphyrin dimer with high 2-γ cross section. Demonstration of reciprocity over a wide range of DLP is important for further development of focal PDT treatments, such as the targeting of feeder vessels in 2-γ PDT of AMD.

  20. Subharmonic focal-length intensities formed by Fresnel lenses.

    PubMed

    Davis, J A; Field, A M; Cottrell, D M

    1994-12-10

    Binary Fresnel lenses produce focused spots at subharmonics of the principal focal length of the lens. The intensities of these focal spots can be controlled by variation of the relative widths of the rings of the Fresnel lens compared with the spacings between the rings. Theory is presented and experimentalverification is provided with Fresnel lenses written onto the magneto-optic spatial light modulator. PMID:20963052

  1. Self-calibration of Antenna Errors Using Focal Plane Arrays

    NASA Astrophysics Data System (ADS)

    Napier, P. J.; Cornwell, T. J.

    The thery of focal-plane correlation is reviewed and applied to the problem of the self-calibration and self-correction of a radio telescope with errors in its reflecting surface. Curves are presented which allow the estimation of focal-plane array size and integration time needed for telescopes with varying amounts of error. It is suggested that the technique may have application to the problem of the construction of large telescopes in space.

  2. Focal fatty infiltration of the liver mimicking metastatic disease.

    PubMed Central

    Bashir, Y.

    1990-01-01

    We report the mistaken diagnosis of metastatic liver disease by ultrasonography in a patient with congestive heart failure and focal fatty infiltration of the liver. Multiple echogenic space-occupying lesions in the liver can be caused by benign conditions as well as tumour deposits and in a debilitated patient the possibility of focal fatty infiltration should always be considered. Images Figure 1 PMID:2201014

  3. Syntelencephaly associated with connected transhemispheric cleft of focal cortical dysplasia.

    PubMed

    Fujimoto, S; Togari, H; Banno, T; Wada, Y

    1999-05-01

    The authors report a female with syntelencephaly associated with a connected transhemispheric cleft of focal cortical dysplasia. Syntelencephaly is a rare anomaly characterized by fusion of the hemispheres in the posterior frontal and parietal regions and is considered a new variant of holoprosencephaly. Cranial magnetic resonance imaging of the patient revealed syntelencephaly associated with bilateral fused clefts of focal cortical dysplasia without the pial-ependymal seam, which was regarded as an incomplete type of schizencephaly. The underlying mechanism is discussed. PMID:10371387

  4. Inflammatory pancreatic masses: problems in differentiating focal pancreatitis from carcinoma

    SciTech Connect

    Neff, C.C.; Simeone, J.F.; Wittenberg, J.; Mueller, P.R.; Ferrucci, J.T. Jr.

    1984-01-01

    The authors studied 19 patients with focal inflammatory masses of the pancreas over an 18-month period. In 13 cases, transhepatic cholangiography and/or endoscopic retrograde cholangiopancreatography were unsuccessful in differentiating pancreatitis from carcinoma. Eighteen patients had a history of alcohol abuse, and 12 had had pancreatitis previously. Pre-existing glandular injury appears to be a prerequisite to formation of focal inflammatory pancreatic masses.

  5. Curriculum Focal Points: A Framework for Pre-K-8 Teachers' Professional Development

    ERIC Educational Resources Information Center

    Cozza, Barbara; Foley, Mary; Laboranti, Carol

    2009-01-01

    Trends in International Mathematics and Science Study raised the concern that the United States (US) mathematics teachers place less emphasis on topics and teach a variety of content strands (Goldsmith, Mark & Kantrov, 2000; Kerachsky, 2008). The overall pattern in the US mathematics classrooms today is that primary and upper elementary teachers…

  6. The nipple: a simple intersection of mammary gland and integument, but focal point of organ function.

    PubMed

    Koyama, Sachiko; Wu, Hsin-Jung; Easwaran, Teresa; Thopady, Sunil; Foley, John

    2013-06-01

    Having glands that secrete milk to nourish neonatal offspring characterizes all mammals. We provide a brief overview of the development and anatomy of nipples and mammary glands in monotremes, marsupials, and marine mammals, and focus on the nipples and mammary glands in terrestrial eutherian species. We first classify eutherians into three groups: the altricial, precocial, and arboreal types based on their rearing system. We then summarize the physiology of lactation and the cell biology of nipples with specific focus on comparing these in the mouse, cow, and human, which represent the three different groups. Finally we propose that the nipple is an example of specialized epidermis. As specialized epidermis, it is dependent the underlying stroma for development and maintenance in adult life. The development of the nipple and signaling pathways that regulate its formation are described. PMID:23674217

  7. Utilizing Proverbs as a Focal Point to Cultural Awareness and Communicative Competence: Illustrations from Africa.

    ERIC Educational Resources Information Center

    Richmond, Edmun B.

    1987-01-01

    Proposes a model of target- and native-language proverb comparison which can be used to assist proverb analysis in the language curriculum, using examples from Mandinka, a West African language. (Author/CB)

  8. Is There a Need for a Library Twinning Focal Point? The IFLA Twinning Project and Beyond.

    ERIC Educational Resources Information Center

    Connolly, Pauline

    This paper discusses the experiences of the IFLA (International Federation of Library Associations and Institutions) Twinning Project, an international twinning database developed and maintained by the IFLA Programme for Universal Availability of Publications, which acts as a kind of "dating agency" aiming to match partner libraries as closely as…

  9. The centrality of victimization. Regaining the focal point of recovery for survivors of child sexual abuse.

    PubMed

    Summit, R C

    1989-06-01

    Psychiatrists have tended to be reluctant followers rather than leaders in the proliferation of concern for child abuse that has developed over the past 25 years. By discounting the relevance of child sexual trauma, psychiatric clinicians and theoreticians overlook not only the therapeutic needs of many survivors but the opportunity to reconceptualize the role of trauma in the etiology and treatment of conditions presumed to be incurable. Present controversies over child sexual abuse are mirrors of past misadventures with uncovering. Since 1860, child abuse has been discovered and then discredited every 35 years by the most visionary clinicians of the day, each faced with the alternative of denouncing the discovery or succumbing to scorn and disgrace. The history of child sexual abuse, whether viewed by parent via child, therapist via patient, or adult survivor via the child within, is one of unimaginable pain and betrayal masked by adult distancing, disavowal, victim blame, and identification with the aggressor. The lurid emotional imperatives of the trauma itself have no place in a just and fair society, and they resist translation into the rational, objective language and concepts of behavioral science. The subject of child sexual abuse is itself so passionate and so paradoxical that it provokes polarized dichotomies at every level, leaving indifference and avoidance as the only hope for serenity. The active nesciance, the determined insistence on not knowing, that pervades every aspect of child sexual abuse encourages the most authoritative scholars to be the most repressive of radical discovery, especially if authority has been achieved as a reaction against youthful vulnerability. Every clinician facing a survivor of childhood sexual trauma faces an assault on personal comfort and authority, just as each patient in that encounter risks intimidation and disgrace. The connections between childhood assault and adult adjustment will be missed unless the therapist can find an unprejudiced path toward mutual acceptance. The promise of genuine understanding and radical resolution of the effects of child sexual abuse is dimmed on both sides by a history of abandonment in the face of scornful, punishing authority. Freud's concept of the unconscious as the arena for successful psychotherapy, his sense of the patient as a normal, healthy individual incapacitated by the effects of buried trauma and his initial optimism for radical recovery from post-traumatic handicaps were soundly derived from his clinical confrontations with child sexual abuse, as were Ferenczi's parallel contributions 35 years later.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:2664733

  10. Recurrent Focal Segmental Glomerulosclerosis and Abatacept: Case Report.

    PubMed

    Alkandari, Omar; Nampoory, Narayanan; Nair, Prasad; Atta, Ahmed; Zakaria, Zakaria; Mossad, Ahmed; Yagan, Jude; Al-Otaibi, Torki

    2016-08-01

    Focal segmental glomerulosclerosis is a common cause of end-stage renal disease in children. Focal segmental glomerulosclerosis recurrence in renal transplants is a challenging disease, and can cause graft dysfunction and loss. Different therapies exist with varying responses, from complete remission to resistance to all modes of treatment. Abatacept was recently introduced as a treatment for primary focal segmental glomerulosclerosis in native kidneys and in recurrent disease after transplant. We present a pediatric case with immunosuppression-resistant primary NPHS2-negative focal segmental glomerulosclerosis recur-rence after renal transplant. The standard therapy for recurrent focal segmental glomerulosclerosis (rituximab, plasmapheresis, high-dose cyclosporine, and corticosteroids) was tried but failed to induce remission. Abatacept (10 mg/kg) was given at 0, 2, and 4 weeks (total, 3 doses) with no good response. We conclude that abatacept may work in patients with B7-1-positive focal segmental glomerulosclerosis recurrence and its efficacy is uncertain in disease with B7-1-negative or unknown staining status. PMID:25432003

  11. [Localized prostate cancer Focal Therapy: "A la carte" Model].

    PubMed

    Linares Espinós, E; Barret, E; Sivaraman, A; Pérez-Reggeti, J I; Sánchez-Salas, R; Rozet, F; Galiano, M; Cathelineau, X

    2016-07-01

    Focal therapy has settled as an alternative to radical treatment in selected cases of localized prostate cancer. The selection of patients who are candidates for focal therapy is based on imaging diagnosis relying on multiparametric MRI and image fusion techniques. Thanks to the oncological results and safety profiles of initial series, various energy sources have been developed over the last years. The availability of multiple types of energy sources for focal therapy, commits us to evaluate what type of energy would be the optimal depending on patient's profile and type of lesion. A unique energy for focal therapy would be ideal, but facing the research of the various types of energy we must identify which one is recommended for each lesion. With the experience of our center in different approaches of focal therapy we propose the "A LA CARTE" MODEL based on localization of the lesion. We present the criteria the "a la carte" model is based on, supported by the published evidence on the use of different ablative therapies for the treatment of localized prostate cancer. Lesion localization, technical characteristics of each type of energy, patient's profile and secondary effects must be considered in every choice of focal therapy. PMID:27416638

  12. Hepatocellular carcinoma in a patient with focal nodular hyperplasia

    PubMed Central

    Lowell, Jeffrey A; Hassan, Anjum; Howard, Todd K

    2002-01-01

    Background Focal nodular hyperplasia is an uncommon liver tumour that typically requires no therapeutic intervention. Case outline A 43-year-old woman with a 20-year history of oral contraceptive use presented with symptomatic bilateral liver masses. Biopsy revealed hepatocellular carcinoma in the right hemiliver and focal nodular hyperplasia in the left hemiliver.At operation,the patient was noted to have multiple liver nodules bilaterally, and all intraoperative biopsies were consistent with focal nodular hyperplasia including a biopsy taken from the region that demonstrated carcinoma preoperatively. Because of the earlier biopsy results and the patient's preoperative symptoms, a right hemihepatectomy was performed. Final pathology revealed hepatocellular carcinoma directly adjacent to an area of focal nodular hyperplasia, as well as multiple other areas of hyperplastic liver tumour. Discussion Although focal nodular hyperplasia is believed to be benign, few studies have followed patients with this tumour beyond three years. Longer-term follow-up studies are needed to determine the natural history of focal nodular hyperplasia, potentially focussing on a subset of patients with either diffuse tumours or prolonged oral contraceptive use. PMID:18332941

  13. Thermomechanical architecture of the VIS focal plane for Euclid

    NASA Astrophysics Data System (ADS)

    Martignac, Jérôme; Carty, Michaël.; Tourette, Thierry; Bachet, Damien; Berthé, Michel; Augueres, Jean-Louis; Amiaux, Jérôme; Fontignie, Jean; Horeau, Benoît; Renaud, Diana; Pottinger, Sabrina; Denniston, James; Winter, Berend; Guttridge, Phillip; Cole, Richard; Cropper, Mark; Niemi, Sami; Coker, John; Hunt, Thomas

    2014-08-01

    One of the main challenges for current and near future space experiments is the increase of focal plane complexity in terms of amount of pixels. In the frame work of the ESA Euclid mission to be launched in 2020, the Euclid Consortium is developing an extremely large and stable focal plane for the VIS instrument. CEA has developed the thermomechanical architecture of that Focal Plane taking into account all the very stringent performance and mission related requirements. The VIS Focal Plane Assembly integrates 36 CCDs (operated at 150K) connected to their front end electronics (operated at 280K) as to obtain one of the largest focal plane (˜0.6 billion pixels) ever built for space application after the GAIA one. The CCDs are CCD273 type specially designed and provided by the e2v company under ESA contract, front end electronics is studied and provided by MSSL. In this paper we first recall the specific requirements that have driven the overall architecture of the VIS-FPA and especially the solutions proposed to cope with the scientific needs of an extremely stable focal plane, both mechanically and thermally. The mechanical structure based on SiC material used for the cold sub assembly supporting the CCDs is detailed. We describe also the modular architecture concept that we have selected taking into account AIT-AIV and programmatic constraints.

  14. All-in-quartz optics for low focal shifts

    NASA Astrophysics Data System (ADS)

    Blomqvist, Mats; Blomster, Ola; Pålsson, Magnus; Campbell, Stuart; Becker, Frank; Rath, Wolfram

    2011-02-01

    High laser power levels in combination with increasing beam quality bring optics performance into focus, particularly with regard to systems with low focal shifts along the optical axis. In industrial applications, this often influences the overall performance of the process, especially if the focal shift is comparable to or in excess of the Rayleigh length. It is commonly accepted that the focal shifts are of thermal nature where lens material, lens coating, geometry and surface contamination all contribute to the direction and extent of the focal shifts. In this paper we will present a novel design of lens packages where a patented all-in-quartz concept is explored. By mounting quartz lenses in hermetically sealed quartz tubes and applying water cooling on the perimeter of the quartz tubes we will reduce or eliminate a number of contributing factors to focal shift problems. The hermetic sealing, carried out in a clean-room environment, will minimize lens surface contamination. Differences in thermal expansion between lens and housing are eliminated as the lens and housing will be of the same material. Absorption of scattered laser light will be efficient as the energy is removed quickly by cooling water and not absorbed by fixed surroundings. Finally, indirect heating from the housing transmitted by radiation and convection to the lenses is avoided. Values of the normalized System Focal Shift Factors (SFSF) for the all-in-quartz optics will be compared to standard lens assemblies at multi-kW laser power levels.

  15. mTOR signaling pathway genes in focal epilepsies.

    PubMed

    Baulac, S

    2016-01-01

    Focal epilepsies, where seizures initiate in spatially limited networks, are the most frequent epilepsy type, accounting for two-thirds of patients. Focal epilepsies have long been thought to be acquired disorders; several focal epilepsy syndromes are now proven to be (genetically heterogeneous) monogenic disorders. While earlier genetic studies have demonstrated a strong contribution of ion channel and neurotransmitter receptor genes, or synaptic secreted protein genes, later work has revealed a new class of genes encoding components of the mechanistic target of rapamycin (mTOR) signal transduction pathway. The mTOR pathway controls a myriad of biological processes among which cell growth and protein synthesis in response to several extracellular and intracellular. Recently, germline mutations have been found in genes encoding the components of the GATOR1 complex (DEPDC5, NPRL2, NPRL3), a repressor of mTORC1. These mutations are increasingly recognized as causing a wide and yet evolving spectrum of focal epilepsy syndromes, with and without cortical structural abnormalities (usually focal cortical dysplasia). Brain somatic mutations in the gene encoding mTOR (MTOR) have recently been linked to focal cortical dysplasia and other associated brain pathologies including hemimegalencephaly. This chapter reviews the genetics and neurobiology of DEPDC5, NPRL2, and NPRL3, and summarizes the clinical and molecular spectrum of GATOR1-related epilepsies. PMID:27323939

  16. Focal spot calibration in a digital breast tomosynthesis system

    NASA Astrophysics Data System (ADS)

    Choi, Jaegu; Hwang, Sun-Jo; Choi, Young-Wook

    2012-05-01

    Digital breast tomosynthesis (DBT) technology is a promising modality for the early detection of breast cancer and could provide clear diagnostic images in which the effect of tissue overlap is alleviated. Accurate calibration of the system geometry is essential for successful image reconstruction in DBT systems. The geometrical calibration of the focal spot in the X-ray tube at the detector plane is one of the most critical parameters of a DBT system. In this paper, a new method using a multi-hole collimator and an iterative calibration algorithm is reported in order to estimate the position of the focal spot at the detector plane. The iterative algorithm is based on the area-distance relationship in the collimator image. The linearity of this relationship has been verified both empirically and theoretically. A focal spot estimate has been achieved regardless of the location of the focal spot in the image. A total of 15 projection images acquired with the DBT system have been successfully reconstructed with geometric information about the focal spot position provided by our new method, and the focal spot estimate method proposed in this paper could be a useful solution for locating optical sources that cannot be viewed or accessed.

  17. Thermal Structure and its Relationship to Focal Depth in the Crust Beneath the Japanese Islands

    NASA Astrophysics Data System (ADS)

    Tanaka, A.; Ishikawa, Y.

    2001-12-01

    The thickness of the seismogenic crustal layer correlates with surface heat flow in most intraplate seismic areas of the world [e.g., Sibson 1982]. It has been realized, however there should be variability of the focal depths among different tectonic settings. Comparisons of the heat flow [Yamano et al., 1997], thermal gradient [Tanaka et al., 1999] and earthquake [Japan Meteorological Agency, JMA] databases for Japanese Islands may provide detailed geologic and geophysical information about the earthquake process of island arc. Each data set is distributed uneven geographically; some are dense, other sparse. All data sets were interpolated onto regular grids of points. The grid is at latitude and longitude with a spacing of 0.25° x 0.25° . Using the JMA data, the earthquake focal depths are evaluated the depth above which 90 % of earthquakes occur, D90 [e.g., Doser and Kanamori, 1986]. D90 ranges from about 10 km to 30 km. This suggests that our analysis cannot catch a locally shallow focal depth. Heat flow and thermal gradient is correlated and the inverse relationship between heat flow or thermal gradient and D90 is obvious. We calculated temperatures in the crust using the steady-state, one-dimensional, heat conductive transport model with heat generation. The evaluated temperatures for D90 range between 200° C and 500° C except for heat flow data more than 130 m W m-2 and thermal gradient data more than 50 K km-1. These very high heat flow and thermal gradient values may not affect the thermal structure in the crust. The consistency of temperature for D90 over a large depth interval almost all over the Japanese Islands supports that the temperature is the dominant factor governing the focal depth in the crust. A comparison of our results with other tectonic regions could provide evidence for variations in temperatures for D90.

  18. Hemispherical infrared focal plane arrays: a new design parameter for the instruments

    NASA Astrophysics Data System (ADS)

    Fendler, M.; Dumas, D.; Chemla, F.; Cohen, M.; Laporte, P.; Tekaya, K.; Le Coarer, E.; Primot, J.; Ribot, H.

    2012-07-01

    In ground based astronomy, mainly all designs of sky survey telescopes are limited by the requirement that the detecting surface is flat whereas the focal surface is curved. Two kinds of solution have been investigated up to now. The first one consists in adding optical systems to flatten the image surface; however this solution complicates the design and increases the system size. Somehow, this solution increases, in the same time, the weight and price of the instrument. The second solution consists in curving artificially the focal surface by using a mosaic of several detectors, which are positioned in a spherical shape. However, this attempt is dedicated to low curvature and is limited by the technical difficulty to control the detectors alignment and tilt between each others. Today we would like to propose an ideal solution which is to curve the focal plane array in a spherical shape, thanks to our monolithic process developed at CEA-LETI based on thinned silicon substrates which allows a 100% optical fill factor. Two infrared uncooled cameras have been performed, using 320 x 256 pixels and 25 μm pitch micro-bolometer arrays curved at a bending radius of 80 mm. These two micro-cameras illustrate the optical system simplification and miniaturization involved by curved focal plane arrays. Moreover, the advantages of curved detectors on the optical performances (Point Spreading Function), as well as on volume and cost savings have been highlighted by the simulation of the opto-mechanical architecture of the spectrometer OptiMOS-EVE for the European Extremely Large Telescope (E-ELT).

  19. Beam control for LINC-NIRVANA: from the binocular entrance pupil to the combined focal plane

    NASA Astrophysics Data System (ADS)

    Bertram, T.; Trowitzsch, J.; Herbst, T. M.; Ragazzoni, R.

    2012-07-01

    LINC-NIRVANA is the near-infrared interferometric imaging camera for the Large Binocular Telescope. Once operational, it will provide an unprecedented combination of angular resolution, sensitivity and field of view. To meet the tight requirements that result from long exposure interferometric imaging over a large field of view, active control beyond fringe tracking and adaptive optics has to be in place in the telescope and in the instrument domain. The incoming beams of the binocular telescope have to be controlled along the entire optical path, from the entrance pupil to the combined focal plane. The beams have to coincide in the focal plane of the science detector, their pointing origins, offsets, orientations, plate scales, and distortions have to match each other and must not change during the observation. Non-common path effects between AO and science channel, flexure and thermal effects have to be compensated and offioading requests from the adaptive optics and fringe tracking systems have to be arbitrated without introducing unwanted optical path length differences or changes in the geometry of the binocular entrance pupil. Beam Control aspects include pointing, co-pointing and field derotation, active optics and collimation control. In this presentation, the constraints for coherent imaging over a 1.5 arcminute field of view are discussed together with a concept for a distributed control scheme.

  20. High-resolution phase imaging of phase singularities in the focal region of a lens

    NASA Astrophysics Data System (ADS)

    Walford, J. N.; Nugent, K. A.; Roberts, A.; Scholten, R. E.

    2002-03-01

    Subwavelength-resolution phase images of phase dislocations at the focal region of a 20×, 0.4-N.A. lens have been obtained by use of an optical fiber interferometer with a tapered probe in one arm. A phase-stepping algorithm is used to determine a quantitative value of the phase at each point in the scan, clearly showing the presence of edge dislocations between the Airy rings of the diffraction pattern near the lens focus, as well as four isolated screw-type singularties caused by astigmatism in the lens.

  1. Comparison of focal properties of square-channel and meridional lobster-eye lenses.

    PubMed

    Barbour, Samuel; Erwin, Daniel A

    2014-12-01

    The lobster-eye telescope with square cross-section channels has been suggested as a possible candidate for a wide-field-of-view x-ray all-sky monitor. However, due to the difficult construction, especially with metals, variations of lobster-eye lenses have been proposed as possible alternatives. This work is a computational comparison of the focal properties of one variant, the meridional lens, with the square-channel lens. For both types of lens, the efficiency of focusing for imaged photons as well as the point-spread function in one dimension is studied for collimated sources. PMID:25606746

  2. Self-correction of telescope surface errors using a correlating focal plane array

    NASA Astrophysics Data System (ADS)

    Cornwell, T. J.; Napier, P. J.

    The effects on the performance of a large radio telescope of aberrations such as reflector surface errors, defocussing, coma and pointing errors can be removed if the telesocpe is equipped with an array feed in its focal plane. If the cross correlations between all possible pairs of array elements are measured, then aberration-free images of radio sources can be obtained. Because of the great cost of building very precise large structures in space, in the future this concept may offer the possibility of a more economical design for a large, high frequency, space-born radio telescope.

  3. The Focal Plane Crystal Spectrometer for the HEAO-B satellite

    NASA Technical Reports Server (NTRS)

    Donaghy, J. F.; Canizares, C. R.

    1978-01-01

    The very low flux from even the brightest (non-solar) X-ray source has discouraged the use of instruments with high spectral resolution because of their inevitably low sensitivity. Mission B of the High Energy Astronomy Observatory will provide the first opportunity for moderate and high resolution spectral studies of celestial X-ray sources with high sensitivity. The Focal Plane Crystal Spectrometer (FPCS) described here is the instrument with the highest spectral resolution. It is designed to allow detailed spectral studies of both point and extended celestial sources in the energy range 0.2-3.3 keV with resolutions of 50 to 1000.

  4. FOCAL mission to 550 thru 1000 AU: Status review 2009

    NASA Astrophysics Data System (ADS)

    Maccone, Claudio

    2010-09-01

    This paper presents a 2009 status review of the "FOCAL" space mission studied by this author and others since 1992 and formally proposed to ESA for consideration after the year 2000. The FOCAL probe is intended to reach distances between 550 and 1000 AU to exploit the huge radio magnification provided there by the gravitational lens of the Sun, as predicted by the general theory of relativity. However, the alignment between the radio source (any star, for instance), the center of the Sun and the FOCAL spacecraft is rather strict, and so it will be necessary to send a FOCAL probe in the opposite sky direction for any stellar system we wish to observe. For instance, before humanity ever embarked in a true interstellar mission even to the closest stars, the Alpha Centauri three stars system at 4.40 light-years from us, it plainly appears that before launching a really interstellar spacecraft it will be better to send a FOCAL probe in the opposite direction of the sky. In fact, the distance it must reach is 278 times smaller than 4.40 light-years, or, in other words, assuming equal engineering problems, FOCAL will take 278 times less than the trip to Alpha Centauri. This makes the Sun focus a reasonable target for our probes to reach within this century already. This paper describes the gravitational lens of the Sun and an updated status review of FOCAL including:(1) The new book by the author, published in March 2009 and entitled "Deep Space Flight and Communications".(2) The utilization of the relativistic KLT (Karhunen-Loève Transform) instead of the classical FFT to insure optimal telecommunications with the Earth during such a relativistic flight.

  5. Focal Plane Alignment Utilizing Optical CMM

    NASA Technical Reports Server (NTRS)

    Liebe, Carl Christian; Meras, Patrick L.; Clark, Gerald J.; Sedaka, Jack J.; Kaluzny, Joel V.; Hirsch, Brian; Decker, Todd A.; Scholtz, Christopher R.

    2012-01-01

    In many applications, an optical detector has to be located relative to mechanical reference points. One solution is to specify stringent requirements on (1) mounting the optical detector relative to the chip carrier, (2) soldering the chip carrier onto the printed circuit board (PCB), and (3) installing the PCB to the mechanical structure of the subsystem. Figure 1 shows a sketch of an optical detector mounted relative to mechanical reference with high positional accuracy. The optical detector is typically a fragile wafer that cannot be physically touched by any measurement tool. An optical coordinate measuring machine (CMM) can be used to position optical detectors relative to mechanical reference points. This approach will eliminate all requirements on positional tolerances. The only requirement is that the PCB is manufactured with oversized holes. An exaggerated sketch of this situation is shown in Figure 2. The sketch shows very loose tolerances on mounting the optical detector in the chip carrier, loose tolerance on soldering the chip carrier to the PCB, and finally large tolerance on where the mounting screws are located. The PCB is held with large screws and oversized holes. The PCB is mounted loosely so it can move freely around. The optical CMM measures the mechanical reference points. Based on these measurements, the required positions of the optical detector corners can be calculated. The optical CMM is commanded to go to the position where one detector corner is supposed to be. This is indicated with the cross-hairs in Figure 2(a). This figure is representative of the image of the optical CMM monitor. Using a suitable tapping tool, the PCB is manually tapped around until the corner of the optical detector is at the crosshairs of the optical CMM. The CMM is commanded to another corner, and the process is repeated a number of times until all corners of the optical detector are within a distance of 10 to 30 microns of the required position. The situation

  6. Variable-focal lens using electroactive polymer actuator

    NASA Astrophysics Data System (ADS)

    Vunder, V.; Punning, A.; Aabloo, A.

    2011-03-01

    The paper describes a simple and cost-effective design and fabrication process of a liquid-filled variable-focal lens. The lens was made of soft polymer material, its shape and curvature can be controlled by hydraulic pressure. An electroactive polymer is used as an actuator. A carbon-polymer composite (CPC) was used. The device is composed of elastic membrane upon a circular lens chamber, a reservoir of liquid, and a channel between them. It was made of three layers of polydimethylsiloxane (PDMS), bonded using the partial curing technique. The channels and reservoir were filled with incompressible liquid after curing process. A CPC actuator was mechanically attached to reservoir to compress or decompress the liquid. Squeezing the liquid between the reservoir and the lens chamber will push the membrane inward or outward resulting in the change of the shape of the lens and alteration of its focal length. Depending on the pressure the lens can be plano-convex or plano-concave or even switch between the two configurations. With only a few minor modifications it is possible to fabricate bi-convex and bi-concave lenses. The lens with a 1 mm diameter and the focal length from infinity to 17 mm is reported. The 5x15mm CPC actuator with the working voltage of only up to +/-2.5 V was capable to alter the focal length within the full range of the focal length in 10 seconds.

  7. The Focal Surface of the JEM-EUSO Instrument

    SciTech Connect

    Kawasaki, Y.; Casolino, M.; Gorodetzky, P.; Santangelo, A.; Ricci, M.; Kajino, F.; Ebisuzaki, T.

    2011-09-22

    The Extreme Universe Space Observatory on JEM/EF (JEM-EUSO) is a space mission to study extremely high-energy cosmic rays. The JEM-EUSO instrument is a wide-angle refractive telescope in the near-ultraviolet wavelength region which will be mounted to the International Space Station. Its goal is to measure time-resolved fluorescence images of extensive air showers in the atmosphere. In this paper we describe in detail the main features and technological aspects of the focal surface of the instrument. The JEM-EUSO focal surface is a spherically curved surface, with an area of about 4.5m{sup 2}. The focal surface detector is made of more than 5,000 multi-anode photomultipliers (MAPMTs). Current baseline is Hamamatsu R11265-03-M64. The approach to the focal surface detector is highly modular. Photo-Detector-Modules (PDM) are the basic units that drive the mechanical structure and data acquisition. Each PDM consists of 9 Elementary Cells (ECs). The EC, which is the basic unit of the MAPMT support structure and of the front-end electronics, contains 4 units of MAPMTs. In total, about 1,200 ECs or about 150 PDMs are arranged on the whole of the focal surface of JEM-EUSO.

  8. New Onset Focal Weakness in Children With Down Syndrome

    PubMed Central

    Worley, Gordon; Shbarou, Rolla; Heffner, Amy N.; Belsito, Karin M.; Capone, George T.; Kishnani, Priya S.

    2009-01-01

    New onset focal weakness is relatively common in patients with Down syndrome (DS), and has broad differential diagnosis. Ten cases of new onset focal weakness in patients with DS were encountered or are currently being followed in two DS clinics, with a combined population of patients of approximately 850, for a clinic population prevalence of 1.2%. The median age at presentation was 4 years old (range 1 month-44 years). The causes of new onset focal weakness were: stroke from Moyamoya disease (two patients); stroke from vaso occlusive disease (one patient); stroke from venus sinus thrombosis (one patient); traumatic subdural hematoma (one patient); brain abscess (one patient); spinal cord injury (SCI) from cervical spinal stenosis (two patients); SCI from atlantoaxial instability (AAI) (one patient); and brachial plexus injury (one patient). Of the 10 patients with focal weakness, 8 had potentially treatable conditions, and 5 had surgery. The differential diagnosis of new onset focal weakness in DS is broad, with diseases reported involving all levels of the nervous system from brain to muscle. For some diagnoses, expeditious diagnosis may improve outcome. PMID:15211649

  9. Design and fabrication of long focal length microlens arrays

    NASA Astrophysics Data System (ADS)

    Hsieh, Hsin-Ta; Lin, Vinna; Hsieh, Jo-Lan; Su, Guo-Dung John

    2011-10-01

    In this paper, we present microlens arrays (MLA) with long focal length (in millimeter range) based on thermal reflow process. The focal length of microlens is usually in the same order of lens diameter or several hundred microns. To extend focal length, we made a photoresist (SU-8) MLA covered by a Polydimethylsiloxane (PDMS) film on a glass substrate. Because the refractive index difference between PDMS and photoresist interface is lower than that of air and MLA interface, light is less bended when passing through MLA and is focused at longer distance. Microlenses of diameters from 50 μm to 240 μm were successfully fabricated. The longest focal length was 2.1 mm from the microlens of 240 μm diameter. The numerical aperture (NA) was reduced 0.06, which is much lower than the smallest NA (~ 0.15) by regular thermal reflow processes. Cured PDMS has high transmittance and becomes parts of MLA without too much optical power loss. Besides, other focal lengths can be realized by modifying the refractive index different between two adjacent materials as described in this paper.

  10. Interictal high-frequency oscillations in focal human epilepsy

    PubMed Central

    Cimbalnik, Jan; Kucewicz, Michal T.; Worrell, Greg

    2016-01-01

    Purpose of review Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intense interest in high-frequency oscillations (HFOs) recorded with intracranial electroencephalography as potential biomarkers to improve epileptogenic brain localization, resective surgery, and focal electrical stimulation. The present review examines the evidence that HFOs are clinically useful biomarkers. Recent findings Performing the PubMed search ‘High-Frequency Oscillations and Epilepsy’ for 2013–2015 identifies 308 articles exploring HFO characteristics, physiological significance, and potential clinical applications. Summary There is strong evidence that HFOs are spatially associated with epileptic brain. There remain, however, significant challenges for clinical translation of HFOs as epileptogenic brain biomarkers: Differentiating true HFO from the high-frequency power changes associated with increased neuronal firing and bandpass filtering sharp transients. Distinguishing pathological HFO from normal physiological HFO. Classifying tissue under individual electrodes as normal or pathological. Sharing data and algorithms so research results can be reproduced across laboratories. Multicenter prospective trials to provide definitive evidence of clinical utility. PMID:26953850

  11. WISE focal plane module lessons learned in light of success

    NASA Astrophysics Data System (ADS)

    Masterjohn, S.; Hogue, H.; Muzilla, M.; Rector, S.; Mattson, R.

    2010-08-01

    DRS Sensors & Targeting Systems, under contract to the Space Dynamics Laboratory of Utah State University, provided the focal plane detector system for NASA's Wide-field Infrared Survey Explorer (WISE). The focal plane detector system consists of two mercury cadmium telluride (MCT) focal plane module assemblies (FPMAs), two arsenic doped silicon (Si:As) Blocked Impurity Band (BIB) FPMAs, electronics to drive the FPMAs and report digital data from them, and the cryogenic and ambient temperature cabling that connect the FPMAs and electronics. The WISE Satellite was launched in late 2009 and has been a very rewarding success. In light of the recent success on orbit, there were many challenges and hurdles the DRS team had to overcome in order to guarantee the ultimate success of the instrument. This report highlights a few of the challenges that the team overcame in hopes that the information can be made available to the astronomy community for future use.

  12. Variation of focal switch with spectrum of a broadband laser

    NASA Astrophysics Data System (ADS)

    Zhang, Biyu; Peng, Runwu; Xie, Haiqing; Zhang, Wei

    2016-05-01

    Effects of the spectrum on focal switch of a broadband laser in a dispersion dual-focus system are presented in this paper. The numerical results show that the two maximum intensities of the broadband laser on the z-axis vary when the central frequency of the broadband laser shifts and the spectrum shape changes, and the variations affect the generation of the focal switch. It is also found that difference of the two maximum intensities tends to increase when the absolute value of central wavelength increases. According to the results in this paper, the generation of the focal switch can be controlled by choosing the shift of the central frequency, the bandwidth, the distance between the two lenses, and the spectrum shape of the broadband laser.

  13. Review and new thinking on LAMOST focal plate support structure

    NASA Astrophysics Data System (ADS)

    Wang, Guomin; Zhang, Kun

    2010-07-01

    LAMOST is a kind of special reflecting Schmidt telescope which solved the problem to achieve both wide FOV and large aperture on one telescope. This feature makes it competitive to do the large sky area survey work. According to the configuration, the focal plate of this kind of telescope will perform three main motions: derotation, tilt and focusing. Normally the focal plate will be supported at a certain height above ground. China has launched the astronomy research at Antarctic Dome A and planned to set up a LAMOST-style telescope there. Considering the harsh environment and terrible remote transportation, a kind of simple and compact support structure of focal plate is proposed in this paper aiming at light weight, easy installation and easy adjustment, based on the review of LAMOST experiments. The calculation and simulation results show that the compact support structure can meet the system requirements.

  14. Experimental characterization of extra-focal radiation in CT scanners

    NASA Astrophysics Data System (ADS)

    Whiting, Bruce R.; Porras-Chaverri, Mariela A.; Evans, Joshua D.; Williamson, Jeffrey F.

    2016-03-01

    Quantitative computed tomography (CT) applications based on statistical iterative reconstruction algorithms require accurate models of the CT acquisition process, with a key component being the x-ray fan beam intensity. We present a method to experimentally determine the extra-focal radiation profile incident on individual CT detectors. Using a tungsten cylinder as a knife edge, a super-sampled signal was created from sinogram data, which traced the "occlusion" of the x-ray source as seen by a detector. By differentiating this signal and correcting for finite detector size and motion blur, the effective source profile can be recovered. Extra-focal scatter was found to be on the order of 1-3 percent of the focal beam intensity, with lower relative magnitude at the isocenter and increasing towards the edge of the fan beam, with its profile becoming asymmetric at large angles. The implications for reconstruction algorithms and QCT applications will be discussed.

  15. Simulation of the Focal Spot of the Accelerator Bremsstrahlung Radiation

    NASA Astrophysics Data System (ADS)

    Sorokin, V.; Bespalov, V.

    2016-06-01

    Testing of thick-walled objects by bremsstrahlung radiation (BR) is primarily performed via high-energy quanta. The testing parameters are specified by the focal spot size of the high-energy bremsstrahlung radiation. In determining the focal spot size, the high- energy BR portion cannot be experimentally separated from the low-energy BR to use high- energy quanta only. The patterns of BR focal spot formation have been investigated via statistical modeling of the radiation transfer in the target material. The distributions of BR quanta emitted by the target for different energies and emission angles under normal distribution of the accelerated electrons bombarding the target have been obtained, and the ratio of the distribution parameters has been determined.

  16. The cheating liver: imaging of focal steatosis and fatty sparing.

    PubMed

    Dioguardi Burgio, Marco; Bruno, Onorina; Agnello, Francesco; Torrisi, Chiara; Vernuccio, Federica; Cabibbo, Giuseppe; Soresi, Maurizio; Petta, Salvatore; Calamia, Mauro; Papia, Giovanni; Gambino, Angelo; Ricceri, Viola; Midiri, Massimo; Lagalla, Roberto; Brancatelli, Giuseppe

    2016-06-01

    Focal steatosis and fatty sparing are a frequent finding in liver imaging, and can mimic solid lesions. Liver regional variations in the degree of fat accumulation can be related to vascular anomalies, metabolic disorders, use of certain drugs or coexistence of hepatic masses. CT and MRI are the modalities of choice for the noninvasive diagnosis of hepatic steatosis. Knowledge of CT and MRI appearance of focal steatosis and fatty sparing is crucial for an accurate diagnosis, and to rule-out other pathologic processes. This paper will review the CT and MRI techniques for the diagnosis of hepatic steatosis and the CT and MRI features of common and uncommon causes of focal steatosis and fatty sparing. PMID:27027652

  17. Focal lesions in cirrhotic liver: what else beyond hepatocellular carcinoma?

    PubMed Central

    Galia, Massimo; Taibbi, Adele; Marin, Daniele; Furlan, Alessandro; Burgio, Marco Dioguardi; Agnello, Francesco; Cabibbo, Giuseppe; Van Beers, Bernard E.; Bartolotta, Tommaso Vincenzo; Midiri, Massimo; Lagalla, Roberto; Brancatelli, Giuseppe

    2014-01-01

    Detection and characterization of focal lesions in the cirrhotic liver may pose a diagnostic dilemma. Several benign and malignant lesions may be found in a cirrhotic liver along with hepatocellular carcinoma (HCC), and may exhibit typical or atypical imaging features. In this pictorial essay, we illustrate computed tomography and magnetic resonance imaging findings of lesions such as simple bile duct cysts, hemangioma, focal nodular hyperplasia-like nodules, peribiliary cysts, intrahepatic cholangiocarcinoma, lymphoma, and metastases, all of which occur in cirrhotic livers with varying prevalences. Pseudolesions, such as perfusion anomalies, focal confluent fibrosis, and segmental hyperplasia, will also be discussed. Imaging characterization of non-HCC lesions in cirrhosis is important in formulating an accurate diagnosis and triaging the patient towards the most appropriate management. PMID:24509186

  18. Role of scintigraphy in focally abnormal sonograms of fatty livers

    SciTech Connect

    Lisbona, R.; Mishkin, S.; Derbekyan, V.; Novales-Diaz, J.A.; Roy, A.; Sanders, L.

    1988-06-01

    Fatty infiltration of the liver may cause a range of focal abnormalities on hepatic sonography which may simulate hepatic nodular lesions. Discrete deposits of fat or islands of normal tissue which are uninvolved by fatty infiltration may stand out as potential space-occupying lesions on the sonograms. Twelve patients with such focally abnormal ultrasound images were referred for liver scintigraphy with /sup 133/Xe and /sup 99m/Tc colloidal SPECT studies to clarify the issue. These examinations helped identify, in nine of 12 patients, the innocent nature of the sonographic abnormalities which were simply related to the fat deposition process. Further, (/sup 99m/Tc)RBC scans defined the additional pathologic process in three patients in whom actual space-occupying lesions were indeed present in the liver. Scintigraphy has an important role to play in the understanding of focal hepatic ultrasound abnormalities particularly in unsuspected hepatic steatosis.

  19. Focal depth measurement of scanning helium ion microscope

    SciTech Connect

    Guo, Hongxuan; Itoh, Hiroshi; Wang, Chunmei; Zhang, Han; Fujita, Daisuke

    2014-07-14

    When facing the challenges of critical dimension measurement of complicated nanostructures, such as of the three dimension integrated circuit, characterization of the focal depth of microscopes is important. In this Letter, we developed a method for characterizing the focal depth of a scanning helium ion microscope (HIM) by using an atomic force microscope tip characterizer (ATC). The ATC was tilted in a sample chamber at an angle to the scanning plan. Secondary electron images (SEIs) were obtained at different positions of the ATC. The edge resolution of the SEIs shows the nominal diameters of the helium ion beam at different focal levels. With this method, the nominal shapes of the helium ion beams were obtained with different apertures. Our results show that a small aperture is necessary to get a high spatial resolution and high depth of field images with HIM. This work provides a method for characterizing and improving the performance of HIM.

  20. Programmable axicon for variable inclination of the focal segment

    NASA Astrophysics Data System (ADS)

    Jaroszewicz, Z.; Climent, V.; Duran, V.; Lancis, J.; Kolodziejczyk, A.; Burvall, A.; Friberg, A. T.

    An axicon creates a long and narrow focal segment along its optical axis and therefore it is widely recognized as a cornerstone element in metrology and alignment techniques. In oblique incidence the shape of the axicon can be designed such that its sharp focal line is retained. However, when an elliptical or circular axicon is illuminated at an angle different from the nominal angle, the focal segment suffers from astigmatism and broadens significantly. The use of a spatial light modulator is proposed for real-time compensation of the ensuing aberration. The result is a diffractive axicon with its degree of ellipticity adjusted to the inclination angle of the incident light, thus producing a diffraction-limited Bessel beam for a wide range of illumination angles.

  1. CLAES focal plane array. [Cryogenic Limb Array Etalon Spectrometer

    NASA Technical Reports Server (NTRS)

    Roche, A. E.; Sterritt, L. W.; Kumer, J. B.; Callary, P. C.; Nielsen, R. L.

    1989-01-01

    The Cryogenic Limb Array Etalon Spectrometer for the NASA Upper Atmospheric Research Satellite uses solid-state focal plane arrays to detect emission from the earth's atmosphere over the IR wavelength range 3.5 to 13 microns. This paper discusses the design of the focal plane detector assembly and compares calculated performance with measurements. Measurements were made of focal plane noise and responsivity as functions of frequency (2 to 500 Hz) and temperature (12 to 19 K), pixel-to-pixel and across-array crosstalk, and linearity over a dynamic range of 100,000. The measurements demonstrate that the arrays satisfy the science requirements, and that, in general, there is reasonable agreement between the measurements and the analytical model.

  2. Efficient subwavelength focusing of light with a long focal depth.

    PubMed

    Huang, He; Li, Qing; Fu, Jian; Wu, James; Lin, Feng; Wu, Xingkun

    2015-10-21

    We demonstrate an efficient method for far-field subwavelength focusing by a novel two-component axicon structure. Annular beams generated by a fiber axicon are focused using a micro-cone reflector, creating a quasi-Bessel beam with a high convergence angle of up to 40°. A center focal spot diameter of 0.41λ was achieved at a power efficiency of over 40%, with a focal depth of 9λ and a working distance as long as 35 μm. We further demonstrate that experimental knife-edge measurements mapping the beam focal intensity agree with numerical simulations of the structure. This method shows demonstrable promise in overcoming the optical focusing limit of single-element axicons and great potential for use in high tolerance, high-resolution applications in optical systems. PMID:26395150

  3. Multifocal array with controllable polarization in each focal spot.

    PubMed

    Zhu, Linwei; Sun, Meiyu; Zhang, Dawei; Yu, Junjie; Wen, Jing; Chen, Jiannong

    2015-09-21

    We propose a method for producing multifocal spot arrays (MSAs) capable of controlling the position and polarization orientation of each focal spot with radially polarized Bessel-Gaussian beam. Based on a simple analytical equation that can be used to manipulate the position of the focal spot, we design a type of multi-zone plate (MZP) composed of many fan-shaped subareas which accordingly generate lateral position-controllable multifocal spots. By adding a π-phase difference between a division line passing through the center of the back aperture with different orientations to corresponding subareas of the MZP, we realize MSAs in which orientations of the linear polarization in each focal spot can be arbitrarily manipulated. Such position and polarization controllable MSAs may potentially have applications in many fields. PMID:26406670

  4. A novel technique of detecting MRI-negative lesion in focal symptomatic epilepsy: intraoperative ShearWave elastography.

    PubMed

    Chan, Huan Wee; Pressler, Ronit; Uff, Christopher; Gunny, Roxanna; St Piers, Kelly; Cross, Helen; Bamber, Jeffrey; Dorward, Neil; Harkness, William; Chakraborty, Aabir

    2014-04-01

    Focal symptomatic epilepsy is the most common form of epilepsy that can often be cured with surgery. A small proportion of patients with focal symptomatic epilepsy do not have identifiable lesions on magnetic resonance imaging (MRI). The most common pathology in this group is type II focal cortical dysplasia (FCD), which is a subtype of malformative brain lesion associated with medication-resistant epilepsy. We present a patient with MRI-negative focal symptomatic epilepsy who underwent invasive electrode recordings. At the time of surgery, a novel ultrasound-based technique called ShearWave Elastography (SWE) was performed. A 0.5 cc lesion was demonstrated on SWE but was absent on B-mode ultrasound and 3-T MRI. Electroencephalography (EEG), positron emission tomography (PET), and magnetoencephalography (MEG) scans demonstrated an abnormality in the right frontal region. On the basis of this finding, a depth electrode was implanted into the lesion. Surgical resection and histology confirmed the lesion to be type IIb FCD. A PowerPoint slide summarizing this article is available for download in the Supporting Information section here. PMID:24588306

  5. Uncooled infrared sensors with digital focal plane array

    NASA Astrophysics Data System (ADS)

    Marshall, Charles A.; Butler, Neal R.; Blackwell, Richard; Murphy, Robert; Breen, Thomas

    1996-06-01

    Loral Infrared & Imaging Systems is developing low cost, high performance, uncooled infrared imaging products for both military and commercial applications. These products are based on the microbolometer technology, a silicon micromachined sensor which combines the wafer level silicon processing with a device structure capable of yielding excellent infrared imaging performance. Here, we report on the development of an uncooled sensor, the LTC500, which incorporates an all digital focal plane array and has a measured NETD of less than 70 mK. The focal plane array and the electronics within the LTC500 have been designed as an integrated unit to meet a broad range of end user applications by providing features such as nonuniformity correction, autogain and level, NTSC video, and digital outputs. The 327 X 245 element focal plane array has a 46.25 micrometers pixel pitch and an on focal plane array 14 bit to analog to digital converter (ADC). The ADC has a measured instantaneous dynamic range of more than 76 dB at a 6.1 MHz output data rate and 60 Hz frame rate. The focal plane array consumes less than 500 mW of power, of which less than 250 mW is used in the ADC. An additional 36 dB of digital coarse offset correction in front of the ADC on the focal plane array results in a total electronic dynamic range of 112 dB. The MRT of the LTC500 camera has been measured at less 0.2 C at f(subscript o).

  6. Megapixel Multi-band QWIP Focal Plane Arrays

    NASA Technical Reports Server (NTRS)

    Gunapala, S. D.; Bandara, S. V.; Liu, J. K.; Rafo, S. B.; Hill, C.; Mumolo, J.; Thang, J.; Tidrow, M.; LeVan, P. D.

    2004-01-01

    A mid-wavelength 1024x1024 pixel quantum well infrared photodetector (QW) focal plane array has been demonstrated with excellent imagery. Noise equivalent differential temperature (NETD) of 19 mK was achieved at 95K operating temperature with f/2.5 optics at 300K background. This focal plane array has shown background limited performance (BLIP) at 90K operating temperature with the same optics and background conditions. In this paper, we will discuss its performance in quantum efficiency, NETD, uniformity, and operability.

  7. Sonic boom focal zones due to tactical aircraft maneuvers

    NASA Astrophysics Data System (ADS)

    Plotkin, Kenneth J.

    1990-10-01

    A study has been conducted of the focal zone 'superbooms' associated with tactical maneuvers of military supersonic aircraft. Focal zone footprints were computed for 21 tactical maneuvers: two for the SR-71 and 19 for fighters engaged in air combat maneuver (ACM) training. These footprints provide quantitative results which may be used for environmental planning. A key finding of this study is that focus factors and footprint areas for high-g fighter maneuvers are substantially smaller than those for gentle maneuvers associated with larger aircraft.

  8. Focal properties of a plane grating in a convergent beam.

    PubMed

    Hall, J T

    1966-06-01

    Focusing from a plane grating can be accomplished by using convergent radiation incident on the grating in such a manner that any incident angle alpha(n), the resulting diffraction angle beta(n), will be on the same side of the grating normal. The theory for the focal properties is developed by applying Fermat's principle of least time to selected terms resulting from a finite series expansion of the system's distance function. Derivations are given for finding the focal curve equation, astigmatism, and coma, of the most usable configuration of the optical components. Discussions of the aberrations disclose methods for eliminating the astigmatism and reducing the coma. PMID:20049009

  9. Point Source Location Sensitivity Analysis

    NASA Astrophysics Data System (ADS)

    Cox, J. Allen

    1986-11-01

    This paper presents the results of an analysis of point source location accuracy and sensitivity as a function of focal plane geometry, optical blur spot, and location algorithm. Five specific blur spots are treated: gaussian, diffraction-limited circular aperture with and without central obscuration (obscured and clear bessinc, respectively), diffraction-limited rectangular aperture, and a pill box distribution. For each blur spot, location accuracies are calculated for square, rectangular, and hexagonal detector shapes of equal area. The rectangular detectors are arranged on a hexagonal lattice. The two location algorithms consist of standard and generalized centroid techniques. Hexagonal detector arrays are shown to give the best performance under a wide range of conditions.

  10. Advances in Focal Plane Wavefront Estimation for Directly Imaging Exoplanets

    NASA Astrophysics Data System (ADS)

    Eldorado Riggs, A. J.; Kasdin, N. Jeremy; Groff, Tyler Dean

    2015-01-01

    To image cold exoplanets directly in visible light, an instrument on a telescope needs to suppress starlight by about 9 orders of magnitude at small separations from the star. A coronagraph changes the point spread function to create regions of high contrast where exoplanets or disks can be seen. Aberrations on the optics degrade the contrast by several orders of magnitude, so all high-contrast imaging systems incorporate one or more deformable mirrors (DMs) to recover regions of high contrast. With a coronagraphic instrument planned for the WFIRST-AFTA space telescope, there is a pressing need for faster, more robust estimation and control schemes for the DMs. Non-common path aberrations limit conventional phase conjugation schemes to medium star-to-planet contrast ratios of about 1e-6. High-contrast imaging requires estimation and control of both phase and amplitude in the same beam path as the science camera. Field estimation is a challenge since only intensity is measured; the most common approach, including that planned for WFIRST-AFTA, is to use DMs to create diversity, via pairs of small probe shapes, thereby allowing disambiguation of the electric field. Most implementations of DM Diversity require at least five images per electric field estimate and require narrowband measurements. This paper describes our new estimation algorithms that improve the speed (by using fewer images) and bandwidth of focal plane wavefront estimation. For narrowband estimation, we are testing nonlinear, recursive algorithms such as an iterative extended Kalman filter (IEKF) to use three images each iteration and build better, more robust estimates. We are also exploring the use of broadband estimation without the need for narrowband sub-filters and measurements. Here we present simulations of these algorithms with realistic noise and small signals to show how they might perform for WFIRST-AFTA. Once validated in simulations, we will test these algorithms experimentally in

  11. Infrared lens thermal effect: equivalent focal shift and calculating model

    NASA Astrophysics Data System (ADS)

    Zhang, Cheng-shuo; Shi, Zelin; Feng, Bin; Xu, Bao-shu

    2014-11-01

    It's well-know that the focal shift of infrared lens is the major factor in degeneration of imaging quality when temperature change. In order to figure out the connection between temperature change and focal shift, partial differential equations of thermal effect on light path are obtained by raytrace method, to begin with. The approximately solution of the PDEs show that focal shift is proportional to temperature change. And a formula to compute the proportional factor is given. In order to understand infrared lens thermal effect deeply, we use defocus by image plane shift at constant temperature to equivalently represent thermal effect on infrared lens. So equivalent focal shift (EFS) is defined and its calculating model is proposed at last. In order to verify EFS and its calculating model, Physical experimental platform including a motorized linear stage with built-in controller, blackbody, target, collimator, IR detector, computer and other devices is developed. The experimental results indicate that EFS make the image plane shift at constant temperature have the same influence on infrared lens as thermal effect and its calculating model is correct.

  12. Extra focal convective suppressing solar collector. Final technical progress report

    SciTech Connect

    1996-05-01

    This progress report describes work done on the Extra Focal Convective Suppressing Solar Collector. The topics of the report include sensor refinement for the tracking electronics, tracking controller refinement, system optics evaluation, absorber system material evaluation and performance, tracking hardware evaluation and refinement, and full scale prototype construction and testing.

  13. Focal Therapy for Prostate Cancer: An "À la Carte" Approach.

    PubMed

    Sivaraman, Arjun; Barret, Eric

    2016-06-01

    Personalizing focal ablation energy for prostate cancer on the basis of cancer location is a novel concept. We propose the use of high-intensity focused ultrasound, cryotherapy, and brachytherapy for posterior, anterior, and apical tumors, respectively, to improve the overall outcome. This concept needs to be verified in prospective studies. PMID:26778462

  14. Confocal microscopy and variable-focal length microlenses

    NASA Astrophysics Data System (ADS)

    Mac Raighne, Aaron M.; Yang, Lisong; Dunbar, L. Andrea; McCabe, Eithne M.; Scharf, Toralf

    2004-07-01

    Confocal microscopy has a unique optical sectioning property which allows three-dimensional images at different depths. Use of a microlens array is a potential alternative to the Nipkow disk for parallel imaging with high throughput in real-time confocal microscopy. The use of variable-focal-length microlenses can provide a way to axially scan the foci electronically avoiding the inflexible mechanical movement of the lens or the sample. Here we demonstrate a combination of a variable-focal-length microlens array and a fiber optic bundle as a way to create a high throughput aperture array that would be potentially applied as confocal imaging in vivo biological specimens. Variable focal length microlenses that we use consist of a liquid crystal film sandwiched between a pair of conductive substrates with patterned electrodes. The incident side of the microlens array was determined by examining the focus distribution in the axial direction. The variation of the focal length obtained by changing the voltage and corresponding focus intensity were measured through a conventional microscope. Meanwhile, the fiber bundle was characterized by coupling with either coherent or incoherent light source. We use the fiber bundle as both a multiple aperture and an image-carrying element and combine it with a microlens array to built up a confocal system. Axial responses are measured in two optical arrangements as a route to investigate endoscope potential.

  15. The Focal Surface of the JEM-EUSO Telescope

    NASA Technical Reports Server (NTRS)

    Kawasaki, Yoshiya

    2007-01-01

    Extreme Universe Space Observatory onboard JEM/EP (JEM-EUSO) is a space mission to study extremely high-energy cosmic rays. The JEM-EUSO instrument is a wide-angle refractive telescope in near-ultraviolet wavelength region to observe time-resolved atmospheric fluorescence images of the extensive air showers from the International Space Station. The focal surface is a spherical curved surface, and its area amounts to about 4.5 square m. The focal surface detector is covered with about 6,000 multi-anode photomultipliers (MAPMTs). The focal surface detector consists of Photo-Detector-Modules, each of which consists of 9 Elementary Cells (ECs). The EC contains 4 units of the MAPMTs. Therefore, about 1,500 ECs or about 160 PDMS are arranged on the whole of the focal surface of JEM- EUSO. The EC is a basic unit of the front-end electronics. The PDM is a, basic unit of the data acquisition system

  16. Use of focal mechanisms to determine stress: a control study.

    USGS Publications Warehouse

    Michael, A.J.

    1987-01-01

    The results of this control study show that focal mechanisms can be inverted to find the best stress tensor, but the resolution is decreased unless the fault planes can be picked a priori. The resolution can also be increased by including constraints on the magnitude of the tangential traction on the fault plane.-from Author

  17. Optical Link For Readout From Focal-Plane Array

    NASA Technical Reports Server (NTRS)

    Fossum, Eric R.; Larsson, Anders G.; Maserjian, Joseph

    1992-01-01

    Outputs of photodetectors modulate beam of light. Proposed optical link carries analog readout signals from photodetectors in focal-plane array to external signal-processing circuitry. Insensitive to electromagnetic interference at suboptical frequencies, and imposes smaller heat load on cryogenic apparatus because it does not include high-power electronic amplifier or laser transmitter within cold chamber.

  18. Analysis of Rapid Multi-Focal Zone ARFI Imaging

    PubMed Central

    Rosenzweig, Stephen; Palmeri, Mark; Nightingale, Kathryn

    2015-01-01

    Acoustic radiation force impulse (ARFI) imaging has shown promise for visualizing structure and pathology within multiple organs; however, because the contrast depends on the push beam excitation width, image quality suffers outside of the region of excitation. Multi-focal zone ARFI imaging has previously been used to extend the region of excitation (ROE), but the increased acquisition duration and acoustic exposure have limited its utility. Supersonic shear wave imaging has previously demonstrated that through technological improvements in ultrasound scanners and power supplies, it is possible to rapidly push at multiple locations prior to tracking displacements, facilitating extended depth of field shear wave sources. Similarly, ARFI imaging can utilize these same radiation force excitations to achieve tight pushing beams with a large depth of field. Finite element method simulations and experimental data are presented demonstrating that single- and rapid multi-focal zone ARFI have comparable image quality (less than 20% loss in contrast), but the multi-focal zone approach has an extended axial region of excitation. Additionally, as compared to single push sequences, the rapid multi-focal zone acquisitions improve the contrast to noise ratio by up to 40% in an example 4 mm diameter lesion. PMID:25643078

  19. Spectrum of PORCN mutations in Focal Dermal Hypoplasia

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Focal Dermal Hypoplasia (FDH), also known as Goltz syndrome (OMIM 305600), is a genetic disorder that affects multiple organ systems early in development. Features of FDH include skin abnormalities, (hypoplasia, atrophy, linear pigmentation, and herniation of fat through dermal defects); papillomas...

  20. Testing of focal plane arrays at the AEDC

    NASA Astrophysics Data System (ADS)

    Nicholson, Randy A.; Mead, Kimberly D.; Smith, Robert W.

    1992-07-01

    A facility was developed at the Arnold Engineering Development Center (AEDC) to provide complete radiometric characterization of focal plane arrays (FPAs). The highly versatile facility provides the capability to test single detectors, detector arrays, and hybrid FPAs. The primary component of the AEDC test facility is the Focal Plane Characterization Chamber (FPCC). The FPCC provides a cryogenic, low-background environment for the test focal plane. Focal plane testing in the FPCC includes flood source testing, during which the array is uniformly irradiated with IR radiation, and spot source testing, during which the target radiation is focused onto a single pixel or group of pixels. During flood source testing, performance parameters such as power consumption, responsivity, noise equivalent input, dynamic range, radiometric stability, recovery time, and array uniformity can be assessed. Crosstalk is evaluated during spot source testing. Spectral response testing is performed in a spectral response test station using a three-grating monochromator. Because the chamber can accommodate several types of testing in a single test installation, a high throughput rate and good economy of operation are possible.

  1. Dosimetry Modeling for Focal Low-Dose-Rate Prostate Brachytherapy

    SciTech Connect

    Al-Qaisieh, Bashar; Mason, Josh; Bownes, Peter; Henry, Ann; Dickinson, Louise; Ahmed, Hashim U.; Emberton, Mark; Langley, Stephen

    2015-07-15

    Purpose: Focal brachytherapy targeted to an individual lesion(s) within the prostate may reduce side effects experienced with whole-gland brachytherapy. The outcomes of a consensus meeting on focal prostate brachytherapy were used to investigate optimal dosimetry of focal low-dose-rate (LDR) prostate brachytherapy targeted using multiparametric magnetic resonance imaging (mp-MRI) and transperineal template prostate mapping (TPM) biopsy, including the effects of random and systematic seed displacements and interseed attenuation (ISA). Methods and Materials: Nine patients were selected according to clinical characteristics and concordance of TPM and mp-MRI. Retrospectively, 3 treatment plans were analyzed for each case: whole-gland (WG), hemi-gland (hemi), and ultra-focal (UF) plans, with 145-Gy prescription dose and identical dose constraints for each plan. Plan robustness to seed displacement and ISA were assessed using Monte Carlo simulations. Results: WG plans used a mean 28 needles and 81 seeds, hemi plans used 17 needles and 56 seeds, and UF plans used 12 needles and 25 seeds. Mean D90 (minimum dose received by 90% of the target) and V100 (percentage of the target that receives 100% dose) values were 181.3 Gy and 99.8% for the prostate in WG plans, 195.7 Gy and 97.8% for the hemi-prostate in hemi plans, and 218.3 Gy and 99.8% for the focal target in UF plans. Mean urethra D10 was 205.9 Gy, 191.4 Gy, and 92.4 Gy in WG, hemi, and UF plans, respectively. Mean rectum D2 cm{sup 3} was 107.5 Gy, 77.0 Gy, and 42.7 Gy in WG, hemi, and UF plans, respectively. Focal plans were more sensitive to seed displacement errors: random shifts with a standard deviation of 4 mm reduced mean target D90 by 14.0%, 20.5%, and 32.0% for WG, hemi, and UF plans, respectively. ISA has a similar impact on dose-volume histogram parameters for all plan types. Conclusions: Treatment planning for focal LDR brachytherapy is feasible. Dose constraints are easily met with a notable

  2. Long Focal Length Large Mirror Fabrication System

    NASA Technical Reports Server (NTRS)

    Bennett, H. E.

    2003-01-01

    The goals of this ambitious program are (1) to develop systems to make large superpolished optical mirrors, (2) to develop low scatter polishing techniques using centrifugal elutriation, (3) to develop a means of measuring scatter at any point on the mirror, (4) to polish a Hindle sphere to measure the optical figure of a one meter diameter convex mandrel, and (5) to fabricate low scatter, large adaptive optic graphite filled, cyanate ester replica transfer mirrors using these mandrels. Deliverables are a 30 cm diameter superpolished composite AO mirror. We fabricated a 1/3rd meter superpolished zerodur flat mandrel and with the support of our major subcontractor, Composite Mirror Applications Inc (CMA) we have demonstrated a 30 cm lightweight cyanate ester mirror with an rms microroughness between 0.6 and 0.8 nm and 8 faceplate influence function of 5 cm. The influence function was chosen to be comparable to the atmospheric correlation coefficient r(sub 0) which is about 5 cm at sea level. There was no print-thru of the graphite fibers in the cyanate ester surface (the bane of many previous efforts to use cyanate ester mirrors). Our subcontractor has devised a means for developing a 30-50 nm thick layer of graphite free pure ester resin on the surface of the mirrors. This graphite fiber filled material has a thermal expansion coefficient in the 10(exp -8) centimeter per Kelvin range (the same range of expansion coefficient as Zerodur and ULE glasses) and does not take up water and swell, so it is a nearly ideal mirror material in these areas. Unfortunately for these 0.8mm thick faceplates, the number of plies is not enough to result in isometric coverage. Isolated figure irregularities can appear, making it necessary to go to thicker faceplates. The influence function will then only approximate the length of r(sub 0), at higher altitudes or longer wavelengths. The influence function goes as the cube of the thickness, so we are now making a faceplate optimized for

  3. Postlumpectomy Focal Brachytherapy for Simultaneous Treatment of Surgical Cavity and Draining Lymph Nodes

    SciTech Connect

    Hrycushko, Brian A.; Li Shihong; Shi Chengyu; Goins, Beth; Liu Yaxi; Phillips, William T.; Otto, Pamela M.; Bao, Ande

    2011-03-01

    Purpose: The primary objective was to investigate a novel focal brachytherapy technique using lipid nanoparticle (liposome)-carried {beta}-emitting radionuclides (rhenium-186 [{sup 186}Re]/rhenium-188 [{sup 188}Re]) to simultaneously treat the postlumpectomy surgical cavity and draining lymph nodes. Methods and Materials: Cumulative activity distributions in the lumpectomy cavity and lymph nodes were extrapolated from small animal imaging and human lymphoscintigraphy data. Absorbed dose calculations were performed for lumpectomy cavities with spherical and ellipsoidal shapes and lymph nodes within human subjects by use of the dose point kernel convolution method. Results: Dose calculations showed that therapeutic dose levels within the lumpectomy cavity wall can cover 2- and 5-mm depths for {sup 186}Re and {sup 188}Re liposomes, respectively. The absorbed doses at 1 cm sharply decreased to only 1.3% to 3.7% of the doses at 2 mm for {sup 186}Re liposomes and 5 mm for {sup 188}Re liposomes. Concurrently, the draining sentinel lymph nodes would receive a high focal therapeutic absorbed dose, whereas the average dose to 1 cm of surrounding tissue received less than 1% of that within the nodes. Conclusions: Focal brachytherapy by use of {sup 186}Re/{sup 188}Re liposomes was theoretically shown to be capable of simultaneously treating the lumpectomy cavity wall and draining sentinel lymph nodes with high absorbed doses while significantly lowering dose to surrounding healthy tissue. In turn, this allows for dose escalation to regions of higher probability of containing residual tumor cells after lumpectomy while reducing normal tissue complications.

  4. Focal mechanism of the seismic series prior to the 2011 El Hierro eruption

    NASA Astrophysics Data System (ADS)

    del Fresno, C.; Buforn, E.; Cesca, S.; Domínguez Cerdeña, I.

    2015-12-01

    The onset of the submarine eruption of El Hierro (10-Oct-2011) was preceded by three months of low-magnitude seismicity (Mw<4.0) characterized by a well documented hypocenter migration from the center to the south of the island. Seismic sources of this series have been studied in order to understand the physical process of magma migration. Different methodologies were used to obtain focal mechanisms of largest shocks. Firstly, we have estimated the joint fault plane solutions for 727 shocks using first motion P polarities to infer the stress pattern of the sequence and to determine the time evolution of principle axes orientation. Results show almost vertical T-axes during the first two months of the series and horizontal P-axes on N-S direction coinciding with the migration. Secondly, a point source MT inversion was performed with data of the largest 21 earthquakes of the series (M>3.5). Amplitude spectra was fitted at local distances (<20km). Reliability and stability of the results were evaluated with synthetic data. Results show a change in the focal mechanism pattern within the first days of October, varying from complex sources of higher non-double-couple components before that date to a simpler strike-slip mechanism with horizontal tension axes on E-W direction the week prior to the eruption onset. A detailed study was carried out for the 8 October 2011 earthquake (Mw=4.0). Focal mechanism was retrieved using a MT inversion at regional and local distances. Results indicate an important component of strike-slip fault and null isotropic component. The stress pattern obtained corresponds to horizontal compression in a NNW-SSE direction, parallel to the southern ridge of the island, and a quasi-horizontal extension in an EW direction. Finally, a simple source time function of 0.3s has been estimated for this shock using the Empirical Green function methodology.

  5. Enchanced interference cancellation and telemetry reception in multipath environments with a single paraboic dish antenna using a focal plane array

    NASA Technical Reports Server (NTRS)

    Mukai, Ryan (Inventor); Vilnrotter, Victor A. (Inventor)

    2011-01-01

    An Advanced Focal Plane Array ("AFPA") for parabolic dish antennas that exploits spatial diversity to achieve better channel equalization performance in the presence of multipath (better than temporal equalization alone), and which is capable of receiving from two or more sources within a field-of-view in the presence of multipath. The AFPA uses a focal plane array of receiving elements plus a spatio-temporal filter that keeps information on the adaptive FIR filter weights, relative amplitudes and phases of the incoming signals, and which employs an Interference Cancelling Constant Modulus Algorithm (IC-CMA) that resolves multiple telemetry streams simultaneously from the respective aero-nautical platforms. This data is sent to an angle estimator to calculate the target's angular position, and then on to Kalman filters FOR smoothing and time series prediction. The resulting velocity and acceleration estimates from the time series data are sent to an antenna control unit (ACU) to be used for pointing control.

  6. The role of focal adhesion kinase in the regulation of cellular mechanical properties

    NASA Astrophysics Data System (ADS)

    Mierke, Claudia Tanja

    2013-12-01

    The regulation of mechanical properties is necessary for cell invasion into connective tissue or intra- and extravasation through the endothelium of blood or lymph vessels. Cell invasion is important for the regulation of many healthy processes such as immune response reactions and wound healing. In addition, cell invasion plays a role in disease-related processes such as tumor metastasis and autoimmune responses. Until now the role of focal adhesion kinase (FAK) in regulating mechanical properties of cells and its impact on cell invasion efficiency is still not well known. Thus, this review focuses on mechanical properties regulated by FAK in comparison to the mechano-regulating protein vinculin. Moreover, it points out the connection between cancer cell invasion and metastasis and FAK by showing that FAK regulates cellular mechanical properties required for cellular motility. Furthermore, it sheds light on the indirect interaction of FAK with vinculin by binding to paxillin, which then impairs the binding of paxillin to vinculin. In addition, this review emphasizes whether FAK fulfills regulatory functions similar to vinculin. In particular, it discusses the differences and the similarities between FAK and vinculin in regulating the biomechanical properties of cells. Finally, this paper highlights that both focal adhesion proteins, vinculin and FAK, synergize their functions to regulate the mechanical properties of cells such as stiffness and contractile forces. Subsequently, these mechanical properties determine cellular invasiveness into tissues and provide a source sink for future drug developments to inhibit excessive cell invasion and hence, metastases formation.

  7. Closed-loop focal plane wavefront control with the SCExAO instrument

    NASA Astrophysics Data System (ADS)

    Martinache, Frantz; Jovanovic, Nemanja; Guyon, Olivier

    2016-09-01

    Aims: This article describes the implementation of a focal plane based wavefront control loop on the high-contrast imaging instrument SCExAO (Subaru Coronagraphic Extreme Adaptive Optics). The sensor relies on the Fourier analysis of conventional focal-plane images acquired after an asymmetric mask is introduced in the pupil of the instrument. Methods: This absolute sensor is used here in a closed-loop to compensate for the non-common path errors that normally affects any imaging system relying on an upstream adaptive optics system.This specific implementation was used to control low-order modes corresponding to eight zernike modes (from focus to spherical). Results: This loop was successfully run on-sky at the Subaru Telescope and is used to offset the SCExAO deformable mirror shape used as a zero-point by the high-order wavefront sensor. The paper details the range of errors this wavefront-sensing approach can operate within and explores the impact of saturation of the data and how it can be bypassed, at a cost in performance. Conclusions: Beyond this application, because of its low hardware impact, the asymmetric pupil Fourier wavefront sensor (APF-WFS) can easily be ported in a wide variety of wavefront sensing contexts, for ground- as well space-borne telescopes, and for telescope pupils that can be continuous, segmented or even sparse. The technique is powerful because it measures the wavefront where it really matters, at the level of the science detector.

  8. Lasting pure-motor deficits after focal posterior internal capsule white-matter infarcts in rats.

    PubMed

    Blasi, Francesco; Whalen, Michael J; Ayata, Cenk

    2015-06-01

    Small white-matter infarcts of the internal capsule are clinically prevalent but underrepresented among currently available animal models of ischemic stroke. In particular, the assessment of long-term outcome, a primary end point in clinical practice, has been challenging due to mild deficits and the rapid and often complete recovery in most experimental models. We, therefore, sought to develop a focal white-matter infarction model that can mimic the lasting neurologic deficits commonly observed in stroke patients. The potent vasoconstrictor endothelin-1 (n=24) or vehicle (n=9) was stereotactically injected into the internal capsule at one of three antero-posterior levels (1, 2, or 3 mm posterior to bregma) in male Sprague-Dawley rats. Endothelin-injected animals showed highly focal (~1 mm(3)) and reproducible ischemic infarcts, with severe axonal and myelin loss accompanied by cellular infiltration when examined 2 and 4 weeks after injection. Only those rats injected with endothelin-1 at the most posterior location developed robust and pure-motor deficits in adhesive removal, cylinder and foot-fault tests that persisted at 1 month, without detectable sensory impairments. In summary, we present an internal capsule stroke model optimized to produce lasting pure-motor deficits in rats that may be suitable to study neurologic recovery and rehabilitation after white-matter injury. PMID:25649992

  9. Natural-focal diseases: mapping experience in Russia

    PubMed Central

    2014-01-01

    Background Natural-focal diseases constitute a serious hazard for human health. Agents and vectors of such diseases belong to natural landscapes. The aim of this study is to identify the diversity and geography of natural-focal diseases in Russia and to develop cartographic approaches for their mapping, including mathematical-cartographical modeling. Russian medico-geographical mapping of natural-focal diseases is highly developed regionally and locally but extremely limited at the national level. To solve this problem, a scientific team of the Faculty of Geography at Lomonosov Moscow State University has developed and implemented a project of a medico-geographical Atlas of Russia “Natural-Focal Diseases”. Methods The mapping is based on medical statistics data. The Atlas contains a series of maps on disease incidence, long-term dynamics of disease morbidity, etc. In addition, other materials available to the authors were used: mapping of the natural environment, field data, archival materials, analyzed satellite images, etc. The maps are processed using ArcGIS (ESRI) software application. Different methods of rendering of mapped phenomena are used (geographical ranges, diagrams, choropleth maps etc.). Results A series of analytical, integrated, and synthetic maps shows disease incidence in the population at both the national and regional levels for the last 15 years. Maps of the mean annual morbidity of certain infections and maps of morbidity dynamics and nosological profiles allow for a detailed analysis of the situation for each of 83 administrative units of the Russian Federation. The degree of epidemic hazard in Russia by natural-focal diseases is reflected in a synthetic medico-geographical map that shows the degree of epidemic risks due to such diseases in Russia and allows one to estimate the risk of disease manifestation in a given region. Conclusions This is the first attempt at aggregation and public presentation of diverse and multifaceted

  10. Brain Network Organization in Focal Epilepsy: A Systematic Review and Meta-Analysis

    PubMed Central

    Jansen, Floor E.; Stam, Cornelis J.; Braun, Kees P. J.; Otte, Willem M.

    2014-01-01

    Normal brain functioning is presumed to depend upon interacting regions within large-scale neuronal networks. Increasing evidence exists that interictal network alterations in focal epilepsy are associated with cognitive and behavioral deficits. Nevertheless, the reported network alterations are inconclusive and prone to low statistical power due to small sample sizes as well as modest effect sizes. We therefore systematically reviewed the existing literature and conducted a meta-analysis to characterize the changes in whole-brain interictal focal epilepsy networks at sufficient power levels. We focused on the two most commonly used metrics in whole-brain networks: average path length and average clustering coefficient. Twelve studies were included that reported whole-brain network average path length and average clustering coefficient characteristics in patients and controls. The overall group difference, quantified as the standardized mean average path length difference between epilepsy and control groups, corresponded to a significantly increased average path length of 0.29 (95% confidence interval (CI): 0.12 to 0.45, p = 0.0007) in the epilepsy group. This suggests a less integrated interictal whole-brain network. Similarly, a significantly increased standardized mean average clustering coefficient of 0.35 (CI: 0.05 to 0.65, p = 0.02) was found in the epilepsy group in comparison with controls, pointing towards a more segregated interictal network. Sub-analyses revealed similar results for functional and structural networks in terms of effect size and directionality for both metrics. In addition, we found individual network studies to be prone to low power due to the relatively small group differences in average path length and average clustering coefficient in combination with small sample sizes. The pooled network characteristics support the hypothesis that focal epilepsy has widespread detrimental effects, that is, reduced integration and increased

  11. Expectant management of focal nodular hyperplasia during pregnancy. A case report.

    PubMed

    Kivnick, S; Greenspoon, J S; Kanter, M H; Gee, C; Fullman, H J

    1992-04-01

    A patient with unresectable focal nodular hyperplasia of the liver completed an uncomplicated pregnancy. Although there is a risk of hepatic rupture during pregnancy, expectant management may be an option for some cases of focal nodular hyperplasia. PMID:1593563

  12. Stress Field in Brazil with Focal Mechanism: Regional and Local Patterns

    NASA Astrophysics Data System (ADS)

    Dias, F.; Assumpcao, M.

    2013-05-01

    determine focal mechanism of low magnitudes events (< 5.0 mb) using distant s seismograph stations. We find examples of stress perturbations induced by local effects (e.g. flexure and continental spreading). The results of this work should be useful for future numerical modeling of intraplate stress field. Assumpção,M.,1998.Seismicity and stresses in the Brazilian passive margin. Bull. Seism. Soc. Am., 88(1),160-169. Herrmann, R. B. (2002). Computer programs in seismology, St. Louis University Earthquake Center, St. Louis, Missouri, www.eas.slu .edu/eqc/eqccps.html. Lithgow-Bertelloni, C., & J.H. Guynn, 2004. Origin of the lithospheric stress field. J. Geophys. Res., 109, B01408, doi:10.1029/2003JB002467. Meijer, P.T., 1995. Dynamics of active continental margins: the Andes and the Aegean regions. PhD Thesis, Utrecht University, The Netherlands. Sokos, E., Zahradnik, J., (2008). ISOLA a Fortran code and a Matlab GUI to perform multiple-point source inversion of seismic data, Computers and Geosciences, 34, 967-97. Watts, A. B., M. Rodger, C. Peirce, C. J. Greenroyd, and R. W. Hobbs (2009). Seismic structure, gravity anomalies, and flexure of the Amazon continental margin, NE Brazil, J. Geophys. Res., 114, B07103, doi:10.1029/2008JB006259.

  13. Shallow gas cloud illumination analysis by the focal beam method

    NASA Astrophysics Data System (ADS)

    Latiff, Abdul Halim Abdul

    2016-02-01

    This research will address the illumination issue of seismic data below a shallow gas cloud, also known as shallow gas accumulation. In general, poor and distorted seismic data underneath gas zones depend on four major factors; namely the velocity of the gas zones, the depth of the target reflector, the location of the source and the receiver during seismic acquisition, and the frequency of the seismic signals. These factors will be scrutinized in detail by using the focal beam method. The focal beam method incorporates the double focusing concept in order to obtain two important attributes for illumination analysis: (i) Resolution function beam, (ii) amplitude versus ray parameter (AVP) imprint, which is obtained by transforming the modelled data into the radon domain. Both illumination attributes are then applied to a gas-affected field in the Malaysia Basin. The results show well-defined illumination beneath the shallow anomalies and provide a better representation of the subsurface.

  14. Alignment techniques required by precise measurement of effective focal length

    NASA Technical Reports Server (NTRS)

    Wise, T. D.

    1980-01-01

    The characteristics of false color imagery produced by instrumentation on earth resource mapping satellites are examined. The spatial fidelity of the imagery is dependent upon the geometric accuracy (GA) and the band-to-band registration (BBR) with which the telescope instrument is assembled. BBR and GA require knowledge of telescope effective focal length (EFL) to one part in 10,000 in order that the next generation of earth mappers be able to carry out their missions. The basis for this level of precision is briefly considered, and a description is given of the means by which such precise EFL measurements have been carried out. Attention is given to accuracy requirements, the technique used to measure effective focal length, possible sources of error in the EFL measurement, approaches for eliminating errors, and the results of the efforts to control measurement errors in EFL determinations.

  15. Design of a variable-focal-length optical system

    NASA Technical Reports Server (NTRS)

    Ricks, D.; Shannon, R. R.

    1984-01-01

    Requirements to place an entire optical system with a variable focal length ranging from 20 to 200 cm within a overall length somewhat less than 100 cm placed severe restrictions on the design of a zoom lens suitable for use on a comet explorer. The requirements of a wavelength range of 0.4 to 1.0 microns produced even greater limitations on the possibilities for a design that included a catadioptric (using mirrors and glass) front and followed by a zooming refractive portion. Capabilities available commercial zoom lenses as well as patents of optical systems are reviewed. Preliminary designs of the refractive optics zoom lens and the catadioptric system are presented and evaluated. Of the two, the latter probably has the best chance of success, so long as the shortest focal lengths are not really needed.

  16. Image-guided focal therapy for prostate cancer.

    PubMed

    Sankineni, Sandeep; Wood, Bradford J; Rais-Bahrami, Soroush; Walton Diaz, Annerleim; Hoang, Anthony N; Pinto, Peter A; Choyke, Peter L; Türkbey, Barış

    2014-11-01

    The adoption of routine prostate specific antigen screening has led to the discovery of many small and low-grade prostate cancers which have a low probability of causing mortality. These cancers, however, are often treated with radical therapies resulting in long-term side effects. There has been increasing interest in minimally invasive focal therapies to treat these tumors. While imaging modalities have improved rapidly over the past decade, similar advances in image-guided therapy are now starting to emerge--potentially achieving equivalent oncologic efficacy while avoiding the side effects of conventional radical surgery. The purpose of this article is to review the existing literature regarding the basis of various focal therapy techniques such as cryotherapy, microwave, laser, and high intensity focused ultrasound, and to discuss the results of recent clinical trials that demonstrate early outcomes in patients with prostate cancer. PMID:25205025

  17. Focal Plane Phase Masks for PIAA: Design and Manufacturing

    NASA Astrophysics Data System (ADS)

    Newman, K.; Conway, J.; Belikov, R.; Guyon, O.

    2016-05-01

    The Phase Induced Amplitude Apodization Complex Mask Coronagraph (PIAACMC) is a coronagraph architecture for the direct detection of extrasolar planets, which can achieve close to the theoretical performance limit of any direct detection system. The primary components of a PIAACMC system are the Phase Induced Amplitude Apodization (PIAA) optics and the complex phase-shifting focal plane mask. PIAA optics have been produced and demonstrated with high coronagraph performance. In this paper, we describe the design process for the phase-shifting focal plane mask, and strategies for smoothing the mask profile. We describe the mask manufacturing process and show manufacturing results. Errors in the fabricated mask profile degrade the system performance, but we can recover performance by refining the manufacturing process and implementing wavefront control.

  18. Effects of non-focal brain dysfunction on visual memory.

    PubMed

    King, M C

    1981-07-01

    Investigated the effects of non-focal brain damage on visual memory abilities with a sample of 114 Ss with confirmed brain-dysfunction and 71 controls who completed the Rey-Osterrieth Complex Figure Test. In contrast, to the findings of earlier studies of patients with focal brain-damage, right-hemisphere lesioned Ss could not be discriminated from left-hemisphere lesioned Ss on the basis of impaired visual recall. All three brain-damaged groups, however, performed more poorly than the control group in both the copy and recall phases of the task. Age and intelligence also were found to be related inversely to task performance. Implications of these data for clinical neuropsychological assessment are discussed. PMID:7263889

  19. Uncooled infrared focal plane array imaging in China

    NASA Astrophysics Data System (ADS)

    Lei, Shuyu

    2015-06-01

    This article reviews the development of uncooled infrared focal plane array (UIFPA) imaging in China in the past decade. Sensors based on optical or electrical read-out mechanism were developed but the latter dominates the market. In resistive bolometers, VOx and amorphous silicon are still the two major thermal-sensing materials. The specifications of the IRFPA made by different manufactures were collected and compared. Currently more than five Chinese companies and institutions design and fabricate uncooled infrared focal plane array. Some devices have sensitivity as high as 30 mK; the largest array for commercial products is 640×512 and the smallest pixel size is 17 μm. Emphasis is given on the pixel MEMS design, ROIC design, fabrication, and packaging of the IRFPA manufactured by GWIC, especially on design for high sensitivities, low noise, better uniformity and linearity, better stabilization for whole working temperature range, full-digital design, etc.

  20. Optofluidic lens with tunable focal length and asphericity.

    PubMed

    Mishra, Kartikeya; Murade, Chandrashekhar; Carreel, Bruno; Roghair, Ivo; Oh, Jung Min; Manukyan, Gor; van den Ende, Dirk; Mugele, Frieder

    2014-01-01

    Adaptive micro-lenses enable the design of very compact optical systems with tunable imaging properties. Conventional adaptive micro-lenses suffer from substantial spherical aberration that compromises the optical performance of the system. Here, we introduce a novel concept of liquid micro-lenses with superior imaging performance that allows for simultaneous and independent tuning of both focal length and asphericity. This is achieved by varying both hydrostatic pressures and electric fields to control the shape of the refracting interface between an electrically conductive lens fluid and a non-conductive ambient fluid. Continuous variation from spherical interfaces at zero electric field to hyperbolic ones with variable ellipticity for finite fields gives access to lenses with positive, zero, and negative spherical aberration (while the focal length can be tuned via the hydrostatic pressure). PMID:25224851

  1. Focal neuromyotonia as a presenting feature of lumbosacral radiculopathy

    PubMed Central

    Raut, Tushar Premraj; Garg, Ravindra Kumar; Chaudhari, Tejendra Singh; Malhotra, Hardeep Singh; Singh, Maneesh Kumar

    2013-01-01

    Neuromyotonia is characterized by motor, sensory, and autonomic features along with characteristic electrophysiologic findings, resulting from hyperexcitability of the peripheral nerves. We describe the case of a 36-year-old man, who presented with the disabling symptoms suggestive of focal neuromyotonia involving both the lower limbs. His neurological examination revealed continuous rippling of both the calf muscles with normal power, reflexes, and sensory examination. Electrophysiology revealed spontaneous activity in the form of doublets, triplets, and neuromyotonic discharges along with the neurogenic motor unit potentials in bilateral L5, S1 innervated muscles. Magnetic resonance imaging lumbosacral spine revealed lumbar intervertebral disc protrusion with severe foraminal and spinal canal stenosis. Patient had good response to steroids and carbamazepine. The disabling focal neuromyotonia, occurring as a result of chronic active radiculopathy, brought the patient to medical attention. Patient responded to medical management. PMID:24339612

  2. Unusual Cause and Presentation of Collapsing Focal Segmental Glomerulosclerosis.

    PubMed

    Bhat, Zeenat Yousuf; Sharma, Neetu; Pillai, Unnikrishnana; Singh, Atul

    2016-01-01

    Collapsing focal segmental glomerulosclerosis (c-FSGS), a structural variant of focal segmental glomeruloslecrosis (FSGS), is considered to be the most aggressive FSGS form. Most patients present with severe nephrotic syndrome and often have rapidly progressing renal failure and progression to end-stage kidney disease. We are reporting a 28-year-old previously healthy woman, who was started on griseofulvin for onchomycosis; she subsequently developed acute renal failure with significant proteinuria. Exposure to the drug caused dramatic decline in the renal function. Renal biopsy was compatible with c-FSGS. To the best of our knowledge, this is the first case of biopsy-proven griseofulvin-associated c-FSGS. Our patient showed rapid improvement in renal function after discontinuation of griseofulvin. Universally, c-FSGS carries poor prognosis, but this case is unique because patient showed rapid improvement in renal function with a short duration after cessation of griseofulvin. PMID:25420079

  3. Two-color quantum well infrared photodetector focal plane arrays

    NASA Astrophysics Data System (ADS)

    Bundas, Jason; Patnaude, Kelly; Dennis, Richard; Burrows, Douglas; Cook, Robert; Reisinger, Axel; Sundaram, Mani; Benson, Robert; Woolaway, James; Schlesselmann, John; Petronio, Susan

    2006-05-01

    QmagiQ LLC, has recently completed building and testing high operability two-color Quantum Well Infrared Photodetector (QWIP) focal plane arrays (FPAs). The 320 x 256 format dual-band FPAs feature 40-micron pixels of spatially registered QWIP detectors based on III-V materials. The vertically stacked detectors in this specific midwave/longwave (MW/LW) design are tuned to absorb in the respective 4-5 and 8-9 micron spectral ranges. The ISC0006 Readout Integrated Circuit (ROIC) developed by FLIR Systems Inc. and used in these FPAs features direct injection (DI) input circuitry for high charge storage with each unit cell containing dual integration capacitors, allowing simultaneous scene sampling and readout for the two distinct wavelength bands. Initial FPAs feature pixel operabilities better than 99%. Focal plane array test results and sample images will be presented.

  4. Optofluidic lens with tunable focal length and asphericity

    PubMed Central

    Mishra, Kartikeya; Murade, Chandrashekhar; Carreel, Bruno; Roghair, Ivo; Oh, Jung Min; Manukyan, Gor; van den Ende, Dirk; Mugele, Frieder

    2014-01-01

    Adaptive micro-lenses enable the design of very compact optical systems with tunable imaging properties. Conventional adaptive micro-lenses suffer from substantial spherical aberration that compromises the optical performance of the system. Here, we introduce a novel concept of liquid micro-lenses with superior imaging performance that allows for simultaneous and independent tuning of both focal length and asphericity. This is achieved by varying both hydrostatic pressures and electric fields to control the shape of the refracting interface between an electrically conductive lens fluid and a non-conductive ambient fluid. Continuous variation from spherical interfaces at zero electric field to hyperbolic ones with variable ellipticity for finite fields gives access to lenses with positive, zero, and negative spherical aberration (while the focal length can be tuned via the hydrostatic pressure). PMID:25224851

  5. A Case of Podocytic Infolding Glomerulopathy with Focal Segmental Glomerulosclerosis

    PubMed Central

    Iguchi, Akira; Sohma, Ayako; Yamazaki, Hajime; Ito, Tomoyuki; Saeki, Takako; Ito, Yumi; Imai, Naohumi; Osawa, Yutaka; Narita, Ichiei

    2013-01-01

    Podocytic infolding glomerulopathy (PIG) has been proposed as a new disease entity. A 14-year-old girl underwent renal biopsy at our institution because of a chance finding of proteinuria. Light microscopic findings revealed a minor glomerular abnormality, but under a higher magnification, after periodic acid methenamine silver staining, a bubbling appearance in the glomerular basement membrane (GBM) was observed. An electron microscopic examination revealed microspheres in the GBM, which were sparse but global. The patient was diagnosed as having PIG. After 3 years, her urinary protein had increased and a second biopsy was performed, showing focal segmental glomerulosclerosis in addition to a lesser degree of podocytic infolding than at the first biopsy. This is the first report of a case complicated by a different type of glomerulonephritis after being diagnosed as PIG. A few cases of PIG are complicated by focal segmental glomerulosclerosis, suggesting several mechanisms for the disorder. PMID:24027576

  6. Optofluidic lens with tunable focal length and asphericity

    NASA Astrophysics Data System (ADS)

    Mishra, Kartikeya; Murade, Chandrashekhar; Carreel, Bruno; Roghair, Ivo; Oh, Jung Min; Manukyan, Gor; van den Ende, Dirk; Mugele, Frieder

    2014-09-01

    Adaptive micro-lenses enable the design of very compact optical systems with tunable imaging properties. Conventional adaptive micro-lenses suffer from substantial spherical aberration that compromises the optical performance of the system. Here, we introduce a novel concept of liquid micro-lenses with superior imaging performance that allows for simultaneous and independent tuning of both focal length and asphericity. This is achieved by varying both hydrostatic pressures and electric fields to control the shape of the refracting interface between an electrically conductive lens fluid and a non-conductive ambient fluid. Continuous variation from spherical interfaces at zero electric field to hyperbolic ones with variable ellipticity for finite fields gives access to lenses with positive, zero, and negative spherical aberration (while the focal length can be tuned via the hydrostatic pressure).

  7. Pictures of focal nodular hyperplasia and hepatocellular adenomas

    PubMed Central

    Sempoux, Christine; Balabaud, Charles; Bioulac-Sage, Paulette

    2014-01-01

    This practical atlas aims to help liver and non liver pathologists to recognize benign hepatocellular nodules on resected specimen. Macroscopic and microscopic views together with immunohistochemical stains illustrate typical and atypical aspects of focal nodular hyperplasia and of hepatocellular adenoma, including hepatocellular adenomas subtypes with references to clinical and imaging data. Each step is important to make a correct diagnosis. The specimen including the nodule and the non-tumoral liver should be sliced, photographed and all different looking areas adequately sampled for paraffin inclusion. Routine histology includes HE, trichrome and cytokeratin 7. Immunohistochemistry includes glutamine synthase and according to the above results additional markers such as liver fatty acid binding protein, C reactive protein and beta catenin may be realized to differentiate focal nodular hyperplasia from hepatocellular adenoma subtypes. Clues for differential diagnosis and pitfalls are explained and illustrated. PMID:25232451

  8. Focal adhesion kinases in adhesion structures and disease.

    PubMed

    Eleniste, Pierre P; Bruzzaniti, Angela

    2012-01-01

    Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development. Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia. Although they are different in structural design and basic function, they share common remodeling proteins such as integrins, talin, paxillin, and the tyrosine kinases FAK, Pyk2, and Src. In this paper, we compare and contrast the basic organization and role of focal adhesions, podosomes, and invadopodia in different cells. In addition, we discuss the role of the tyrosine kinases, FAK, Pyk2, and Src, which are critical for the function of the different adhesion structures. Finally, we discuss the essential role of these tyrosine kinases from the perspective of human diseases. PMID:22888421

  9. Focal Adhesion Kinases in Adhesion Structures and Disease

    PubMed Central

    Eleniste, Pierre P.; Bruzzaniti, Angela

    2012-01-01

    Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development. Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia. Although they are different in structural design and basic function, they share common remodeling proteins such as integrins, talin, paxillin, and the tyrosine kinases FAK, Pyk2, and Src. In this paper, we compare and contrast the basic organization and role of focal adhesions, podosomes, and invadopodia in different cells. In addition, we discuss the role of the tyrosine kinases, FAK, Pyk2, and Src, which are critical for the function of the different adhesion structures. Finally, we discuss the essential role of these tyrosine kinases from the perspective of human diseases. PMID:22888421

  10. Focal nodular hyperplasia with major sinusoidal dilatation: a misleading entity

    PubMed Central

    Laumonier, Hervé; Frulio, Nora; Laurent, Christophe; Balabaud, Charles; Zucman-Rossi, Jessica; Bioulac-Sage, Paulette

    2010-01-01

    Focal nodular hyperplasia (FNH) is a benign liver lesion thought to be a non-specific response to locally increased blood flow. Although the diagnosis of FNH and hepatocellular adenoma (HCA) has made great progress over the last few years using modern imaging techniques, there are still in daily practice some difficulties concerning some atypical nodules. Here, the authors report the case of a 47-year-old woman with a single liver lesion thought to be, by imaging, an inflammatory HCA with major sinusoidal congestion. This nodule was revealed to be, at the microscopical level and after specific immunostaining and molecular analysis, an FNH with sinusoidal dilatation (so-called telangiectatic focal nodular hyperplasia). PMID:22798311

  11. Image-guided focal therapy for prostate cancer

    PubMed Central

    Sankineni, Sandeep; Wood, Bradford J.; Rais-Bahrami, Soroush; Diaz, Annerleim Walton; Hoang, Anthony N.; Pinto, Peter A.; Choyke, Peter L.; Türkbey, Barış

    2014-01-01

    The adoption of routine prostate specific antigen screening has led to the discovery of many small and low-grade prostate cancers which have a low probability of causing mortality. These cancers, however, are often treated with radical therapies resulting in long-term side effects. There has been increasing interest in minimally invasive focal therapies to treat these tumors. While imaging modalities have improved rapidly over the past decade, similar advances in image-guided therapy are now starting to emerge—potentially achieving equivalent oncologic efficacy while avoiding the side effects of conventional radical surgery. The purpose of this article is to review the existing literature regarding the basis of various focal therapy techniques such as cryotherapy, microwave, laser, and high intensity focused ultrasound, and to discuss the results of recent clinical trials that demonstrate early outcomes in patients with prostate cancer. PMID:25205025

  12. Simultaneous imaging of multiple focal planes using a two-photon scanning microscope

    NASA Astrophysics Data System (ADS)

    Amir, W.; Carriles, R.; Hoover, E. E.; Planchon, T. A.; Durfee, C. G.; Squier, J. A.

    2007-06-01

    Despite all the advances in nonlinear microscopy, all existing instruments are constrained to obtain images of one focal plane at a time. In this Letter we demonstrate a two-photon absorption fluorescence scanning microscope capable of imaging two focal planes simultaneously. This is accomplished by temporally demultiplexing the signal coming from two focal volumes at different sample depths. The scheme can be extended to three or more focal planes.

  13. Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration

    PubMed Central

    Wu, Jui-Chung; Chen, Yu-Chen; Kuo, Chih-Ting; Wenshin Yu, Helen; Chen, Yin-Quan; Chiou, Arthur; Kuo, Jean-Cheng

    2015-01-01

    Directed cell migration requires dynamical control of the protein complex within focal adhesions (FAs) and this control is regulated by signaling events involving tyrosine phosphorylation. We screened the SH2 domains present in tyrosine-specific kinases and phosphatases found within FAs, including SRC, SHP1 and SHP2, and examined whether these enzymes transiently target FAs via their SH2 domains. We found that the SRC_SH2 domain and the SHP2_N-SH2 domain are associated with FAs, but only the SRC_SH2 domain is able to be regulated by focal adhesion kinase (FAK). The FAK-dependent association of the SRC_SH2 domain is necessary and sufficient for SRC FA targeting. When the targeting of SRC into FAs is inhibited, there is significant suppression of SRC-mediated phosphorylation of paxillin and FAK; this results in an inhibition of FA formation and maturation and a reduction in cell migration. This study reveals an association between FAs and the SRC_SH2 domain as well as between FAs and the SHP2_N-SH2 domains. This supports the hypothesis that the FAK-regulated SRC_SH2 domain plays an important role in directing SRC into FAs and that this SRC-mediated FA signaling drives cell migration. PMID:26681405

  14. X-ray focal spot locating apparatus and method

    DOEpatents

    Gilbert, Hubert W.

    1985-07-30

    An X-ray beam finder for locating a focal spot of an X-ray tube includes a mass of X-ray opaque material having first and second axially-aligned, parallel-opposed faces connected by a plurality of substantially identical parallel holes perpendicular to the faces and a film holder for holding X-ray sensitive film tightly against one face while the other face is placed in contact with the window of an X-ray head.

  15. Back focal plane imaging spectroscopy of photonic crystals

    NASA Astrophysics Data System (ADS)

    Wagner, Rebecca; Heerklotz, Lars; Kortenbruck, Nikolai; Cichos, Frank

    2012-08-01

    Back focal plane imaging spectroscopy is introduced to record angle resolved emission spectra of 3-dimensional colloidal photonic crystals. The auto-fluorescence of the colloids is used to quickly map the photonic band structure up to 72 % of the solid angle of a semisphere with the help of a high numerical aperture objective. Local excitation provides spatially resolved information on the photonic crystal's optical properties. The obtained fractional density of states allows direct conclusions on the crystal's stacking faults or defects.

  16. Modulation transfer function of QWIP and superlattice focal plane arrays

    NASA Astrophysics Data System (ADS)

    Gunapala, S. D.; Rafol, S. B.; Ting, D. Z.; Soibel, A.; Liu, J. K.; Khoshakhlagh, A.; Keo, S. A.; Mumolo, J. M.; Nguyen, J.

    2013-07-01

    Modulation transfer function (MTF) is the ability of an imaging system to faithfully image a given object. The MTF of an imaging system quantifies the ability of the system to resolve or transfer spatial frequencies. In this paper we will discuss the detail MTF measurements of a 1024 × 1024 pixel multi-band quantum well infrared photodetector and 320 × 256 pixel long-wavelength InAs/GaSb superlattice infrared focal plane arrays.

  17. Stress tensor and focal mechanisms in the Dead Sea basin

    NASA Astrophysics Data System (ADS)

    Hofstetter, A.; Dorbath, C.; Dorbath, L.; Braeuer, B.; Weber, M.

    2016-04-01

    We use the recorded seismicity, confined to the Dead Sea basin and its boundaries, by the Dead Sea Integrated Research (DESIRE) portable seismic network and the Israel and Jordan permanent seismic networks for studying the mechanisms of earthquakes in the Dead Sea basin. The observed seismicity in the Dead Sea basin is divided into nine regions according to the spatial distribution of the earthquakes and the known tectonic features. The large number of recording stations and the adequate station distribution allowed the reliable determinations of 494 earthquake focal mechanisms. For each region, based on the inversion of the observed polarities of the earthquakes, we determine the focal mechanisms and the associated stress tensor. For 159 earthquakes, out of the 494 focal mechanisms, we could determine compatible fault planes. On the eastern side, the focal mechanisms are mainly strike-slip mechanism with nodal planes in the N-S and E-W directions. The azimuths of the stress axes are well constrained presenting minimal variability in the inversion of the data, which is in agreement with the Eastern Boundary fault on the east side of the Dead Sea basin and what we had expected from the regional geodynamics. However, larger variabilities of the azimuthal and dip angles are observed on the western side of the basin. Due to the wider range of azimuths of the fault planes, we observe the switching of σ1 and σ2 or the switching of σ2 and σ3 as major horizontal stress directions. This observed switching of stress axes allows having dip-slip and normal mechanisms in a region that is dominated by strike-slip motion.

  18. Optimization of starshades: focal plane versus pupil plane

    NASA Astrophysics Data System (ADS)

    Flamary, R.; Aime, C.

    2014-09-01

    We search for the best possible transmission for an external occulter coronagraph that is dedicated to the direct observation of terrestrial exoplanets. We show that better observation conditions are obtained when the flux in the focal plane is minimized in the zone in which the exoplanet is observed, instead of for the total flux received by the telescope. We describe the transmission of the occulter as a sum of basis functions. For each element of the basis, we numerically computed the Fresnel diffraction at the aperture of the telescope and the complex amplitude at its focus. The basis functions are circular disks that are linearly apodized over a few centimeters (truncated cones). We complemented the numerical calculation of the Fresnel diffraction for these functions by a comparison with pure circular disks (cylinder) for which an analytical expression, based on a decomposition in Lommel series, is available. The technique of deriving the optimal transmission for a given spectral bandwidth is a classical regularized quadratic minimization of intensities, but linear optimizations can be used as well. Minimizing the integrated intensity on the aperture of the telescope or for selected regions of the focal plane leads to slightly different transmissions for the occulter. For the focal plane optimization, the resulting residual intensity is concentrated behind the geometrical image of the occulter, in a blind region for the observation of an exoplanet, and the level of background residual starlight becomes very low outside this image. Finally, we provide a tolerance analysis for the alignment of the occulter to the telescope, which also favors the focal plane optimization. This means that telescope offsets of a few decimeters do not strongly reduce the efficiency of the occulter.

  19. Focal Molography: Coherent Microscopic Detection of Biomolecular Interaction

    NASA Astrophysics Data System (ADS)

    Fattinger, Christof

    2014-07-01

    We introduce and theoretically investigate here a novel analytical method that we have called focal molography, in which molecular interactions are made visible through scattering of coherent light by a coherent pattern of molecules. The scattered light quantifies the presence of molecules at molecular interaction sites. It is separated from noncoherent background scatter by a combination of local dark-field illumination, interference enhancement, and spatial filtering. The latter is achieved by holographic focusing of the wave field generated by the coherently assembled molecules onto an Airy disk and by subtraction of the noncoherent irradiance in the focal plane outside the disk from the irradiance in the disk. This new microscopic method allows distinct detection of low-refractive-index contrast in the nanoenvironment of biomolecules from which information on the interaction of the coherently assembled molecules with molecules in a liquid or gaseous sample may be deduced. The noncoherent surroundings of the coherently assembled molecules consist of freely diffusing solvent and solute molecules. The surroundings, as well as changes in temperature, do not contribute to the coherent signal in the diffraction focus. Interference lithography or high-resolution-imaging lithography can be used to synthesize the coherent pattern of molecules on a monolithic substrate. The coherent pattern of molecules constitutes a synthetic phase hologram that creates a diffraction-limited light wave. We suggest the term "mologram" for the coherent assembly of functional nanostructures and the term "focal molography" for label-free or labeled analysis of molecular interactions through the measurement of the properties of light in the focus of the mologram. We derive analytical formulas that express the detection signal and the sensitivity of focal molography on the surface of a high-refractive-index thin-film optical waveguide in terms of known parameters. We discuss the

  20. Focal mechanisms of recent earthquakes in the Southern Korean Peninsula

    NASA Astrophysics Data System (ADS)

    Park, Jong-Chan; Kim, Woohan; Chung, Tae Woong; Baag, Chang-Eob; Ree, Jin-Han

    2007-06-01

    We evaluate the stress field in and around the southern Korean Peninsula with focal mechanism solutions, using the data collected from 71 earthquakes (ML = 1.9-5.2) between 1999 and 2004. For this, the hypocentres were relocated and well-constrained fault plane solutions were obtained from the data set of 1270 clear P-wave polarities and 46 SH/P amplitude ratios. The focal mechanism solutions indicate that the prevailing faulting types in South Korea are strike-slip-dominant-oblique-slip faultings with minor reverse-slip component. The maximum principal stresses (σ1) estimated from fault-slip inversion analysis of the focal mechanism solutions show a similar orientation with E-W trend (269° -275°) and low-angle plunge (10° -25°) for all tectonic provinces in South Korea, consistent with the E-W trending maximum horizontal stress (σHmax) of the Amurian microplate reported from in situ stress measurements and earthquake focal mechanisms. The directions of the intermediate (σ2) and minimum (σ3) principal stresses of the Gyeongsang Basin are, however, about 90 deg off from those of the other tectonic provinces on a common σ2-σ3 plane, suggesting a permutation of σ2 and σ3. Our results incorporated with those from the kinematic studies of the Quaternary faults imply that NNW- to NE-striking faults (dextral strike-slip or oblique-slip with a reverse-slip component) are highly likely to generate earthquakes in South Korea.

  1. Focal adhesion kinase is involved in mechanosensing during fibroblast migration

    NASA Technical Reports Server (NTRS)

    Wang, H. B.; Dembo, M.; Hanks, S. K.; Wang, Y.

    2001-01-01

    Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase localized at focal adhesions and is believed to mediate adhesion-stimulated effects. Although ablation of FAK impairs cell movement, it is not clear whether FAK might be involved in the guidance of cell migration, a role consistent with its putative regulatory function. We have transfected FAK-null fibroblasts with FAK gene under the control of the tetracycline repression system. Cells were cultured on flexible polyacrylamide substrates for the detection of traction forces and the application of mechanical stimulation. Compared with control cells expressing wild-type FAK, FAK-null cells showed a decrease in migration speed and directional persistence. In addition, whereas FAK-expressing cells responded to exerted forces by reorienting their movements and forming prominent focal adhesions, FAK-null cells failed to show such responses. Furthermore, FAK-null cells showed impaired responses to decreases in substrate flexibility, which causes control cells to generate weaker traction forces and migrate away from soft substrates. Cells expressing Y397F FAK, which cannot be phosphorylated at a key tyrosine site, showed similar defects in migration pattern and force-induced reorientation as did FAK-null cells. However, other aspects of F397-FAK cells, including the responses to substrate flexibility and the amplification of focal adhesions upon mechanical stimulation, were similar to that of control cells. Our results suggest that FAK plays an important role in the response of migrating cells to mechanical input. In addition, phosphorylation at Tyr-397 is required for some, but not all, of the functions of FAK in cell migration.

  2. Design study of the accessible focal plane telescope for shuttle

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The design and cost analysis of an accessible focal plane telescope for Spacelab is presented in blueprints, tables, and graphs. Topics covered include the telescope tube, the telescope mounting, the airlock plus Spacelab module aft plate, the instrument adapter, and the instrument package. The system allows access to the image plane with instrumentation that can be operated by a scientist in a shirt sleeve environment inside a Spacelab module.

  3. Precise annealing of focal plane arrays for optical detection

    SciTech Connect

    Bender, Daniel A.

    2015-09-22

    Precise annealing of identified defective regions of a Focal Plane Array ("FPA") (e.g., exclusive of non-defective regions of the FPA) facilitates removal of defects from an FPA that has been hybridized and/or packaged with readout electronics. Radiation is optionally applied under operating conditions, such as under cryogenic temperatures, such that performance of an FPA can be evaluated before, during, and after annealing without requiring thermal cycling.

  4. Successful treatment of multi-focal XDR tuberculous osteomyelitis.

    PubMed

    Alshukairi, Abeer N; Alrajhi, Abdulrahman A; Alamri, Abdulfattah W; Alothman, Adel F

    2016-01-01

    We herein describe the nosocomial transmission of a pre-XDR or MDR case of pulmonary tuberculosis in a HIV-negative health care worker in an area endemic for MDR and XDR tuberculosis. Following inadequate therapy and non-compliance, he presented with extra-pulmonary XDR tuberculosis in the form of multi-focal osteomyelitis and encysted pleural effusion. He was cured after two years of treatment with various anti-tuberculous drugs in addition to interferon gamma. PMID:26631433

  5. Studies on design of 351  nm focal plane diagnostic system prototype and focusing characteristic of SGII-upgraded facility at half achievable energy performance.

    PubMed

    Liu, Chong; Ji, Lailin; Yang, Lin; Zhao, Dongfeng; Zhang, Yanfeng; Liu, Dong; Zhu, Baoqiang; Lin, Zunqi

    2016-04-01

    In order to obtain the intensity distribution of a 351 nm focal spot and smoothing by spectral dispersion (SSD) focal plane profile of a SGII-upgraded facility, a type of off-axis imaging system with three spherical mirrors, suitable for a finite distance source point to be imaged near the diffraction limit has been designed. The quality factor of the image system is 1.6 times of the diffraction limit tested by a 1053 nm point source. Because of the absence of a 351 nm point source, we can use a Collins diffraction imaging integral with respect to λ=351  nm, corresponding to a quality factor that is 3.8 times the diffraction limit at 351 nm. The calibration results show that at least the range of ±10  mrad of view field angle and ±50  mm along the axial direction around the optimum object distance can be satisfied with near diffraction limited image that is consistent with the design value. Using this image system, the No. 2 beam of the SGII-upgraded facility has been tested. The test result of the focal spot of final optics assembly (FOA) at 351 nm indicates that about 80% of energy is encompassed in 14.1 times the diffraction limit, while the output energy of the No. 2 beam is 908 J at 1053 nm. According to convolution theorem, the true value of a 351 nm focal spot of FOA is about 12 times the diffraction limit because of the influence of the quality factor. Further experimental studies indicate that the RMS value along the smoothing direction is less than 15.98% in the SSD spot test experiment. Computer simulations show that the quality factor of the image system used in the experiment has almost no effect on the SSD focal spot test. The image system can remarkably distort the SSD focal spot distribution under the circumstance of the quality factor 15 times worse than the diffraction limit. The distorted image shows a steep slope in the contour of the SSD focal spot along the smoothing direction that otherwise has a relatively flat top region

  6. Phase-shifting point diffraction interferometer

    DOEpatents

    Medecki, Hector

    1998-01-01

    Disclosed is a point diffraction interferometer for evaluating the quality of a test optic. In operation, the point diffraction interferometer includes a source of radiation, the test optic, a beam divider, a reference wave pinhole located at an image plane downstream from the test optic, and a detector for detecting an interference pattern produced between a reference wave emitted by the pinhole and a test wave emitted from the test optic. The beam divider produces separate reference and test beams which focus at different laterally separated positions on the image plane. The reference wave pinhole is placed at a region of high intensity (e.g., the focal point) for the reference beam. This allows reference wave to be produced at a relatively high intensity. Also, the beam divider may include elements for phase shifting one or both of the reference and test beams.

  7. Phase-shifting point diffraction interferometer

    DOEpatents

    Medecki, H.

    1998-11-10

    Disclosed is a point diffraction interferometer for evaluating the quality of a test optic. In operation, the point diffraction interferometer includes a source of radiation, the test optic, a beam divider, a reference wave pinhole located at an image plane downstream from the test optic, and a detector for detecting an interference pattern produced between a reference wave emitted by the pinhole and a test wave emitted from the test optic. The beam divider produces separate reference and test beams which focus at different laterally separated positions on the image plane. The reference wave pinhole is placed at a region of high intensity (e.g., the focal point) for the reference beam. This allows reference wave to be produced at a relatively high intensity. Also, the beam divider may include elements for phase shifting one or both of the reference and test beams. 8 figs.

  8. mRNA redistribution during permanent focal cerebral ischemia.

    PubMed

    Lewis, Monique K; Jamison, Jill T; Dunbar, Joseph C; DeGracia, Donald J

    2013-12-01

    Translation arrest occurs in neurons following focal cerebral ischemia and is irreversible in penumbral neurons destined to die. Following global cerebral ischemia, mRNA is sequestered away from 40S ribosomal subunits as mRNA granules, precluding translation. Here, we investigated mRNA granule formation using fluorescence in situ histochemistry out to 8 h permanent focal cerebral ischemia using middle cerebral artery occlusion in Long Evans rats with and without diabetes. Neuronal mRNA granules colocalized with PABP, HuR, and NeuN, but not 40S or 60S ribosomal subunits, or organelle markers. The volume of brain with mRNA granule-containing neurons decreased exponentially with ischemia duration, and was zero after 8 h permanent focal cerebral ischemia or any duration of ischemia in diabetic rats. These results show that neuronal mRNA granule response has a limited range of insult intensity over which it is expressed. Identifying the limits of effective neuronal stress response to ischemia will be important for developing effective stroke therapies. PMID:24323415

  9. Focal Laser Ablation of Prostate Cancer: Definition, Needs, and Future

    PubMed Central

    Colin, Pierre; Mordon, Serge; Nevoux, Pierre; Marqa, Mohammed Feras; Ouzzane, Adil; Puech, Philippe; Bozzini, Gregory; Leroux, Bertrand; Villers, Arnauld; Betrouni, Nacim

    2012-01-01

    Current challenges and innovations in prostate cancer management concern the development of focal therapies that allow the treatment of only the cancer areas sparing the rest of the gland to minimize the potential morbidity. Among these techniques, focal laser ablation (FLA) appears as a potential candidate to reach the goal of focusing energy delivery on the identified targets. The aim of this study is to perform an up-to-date review of this new therapeutic modality. Relevant literature was identified using MEDLINE database with no language restrictions (entries: focal therapy, laser interstitial thermotherapy, prostate cancer, FLA) and by cross-referencing from previously identified studies. Precision, real-time monitoring, MRI compatibility, and low cost of integrated system are principal advantages of FLA. Feasibility and safety of this technique have been reported in phase I assays. FLA might eventually prove to be a middle ground between active surveillance and radical treatment. In conclusion, FLA may have found a role in the management of prostate cancer. However, further trials are required to demonstrate the oncologic effectiveness in the long term. PMID:22666240

  10. Brain somatic mutations in MTOR leading to focal cortical dysplasia.

    PubMed

    Lim, Jae Seok; Lee, Jeong Ho

    2016-02-01

    Focal cortical dysplasia type II (FCDII) is a focal malformation of the developing cerebral cortex and the major cause of intractable epilepsy. However, since the molecular genetic etiology of FCD has remained enigmatic, the effective therapeutic target for this condition has remained poorly understood. Our recent study on FCD utilizing various deep sequencing platforms identified somatic mutations in MTOR (existing as low as 1% allelic frequency) only in the affected brain tissues. We observed that these mutations induced hyperactivation of the mTOR kinase. In addition, focal cortical expression of mutant MTOR using in utero electroporation in mice, recapitulated the neuropathological features of FCDII, such as migration defect, cytomegalic neuron and spontaneous seizures. Furthermore, seizures and dysmorphic neurons were rescued by the administration of mTOR inhibitor, rapamycin. This study provides the first evidence that brain somatic activating mutations in MTOR cause FCD, and suggests the potential drug target for intractable epilepsy in FCD patients. [BMB Reports 2016; 49(2): 71-72]. PMID:26779999

  11. Focal Hyperhidrosis Associated with Recurrent Urinary Tract Infections

    PubMed Central

    Madhwapathi, Vidya; Ladoyanni, Evmorfia

    2016-01-01

    Hyperhidrosis affects almost 3% of the population and is characterized by sweating that occurs in excess of that needed for normal thermoregulation. It can occur as a primary disease or secondary to underlying clinical conditions. Hyperhidrosis can stem from neurogenic sympathetic over activity involving normal eccrine glands. We report the interesting case of a 75-year-old male patient with a 6-month history of new onset secondary focal hyperhidrosis of buttocks, pelvis, and upper thighs. Each time his symptoms worsened he was found to have culture positive urine samples for Escherichia coli (E. coli). He underwent urological investigation and was found to have urethral strictures and cystitis. The hyperhidrosis improved each time his urinary tract infection (UTI) was treated with antibiotics and continued to remain stable with a course of prophylactic trimethoprim. We hypothesize that the patient's urethral strictures led to inhibition in voiding which in turn increased the susceptibility to UTIs. Accumulation of urine and increased bladder pressure in turn raised sympathetic nerve discharge leading to excessive sweating. We recommend that a urine dip form part of the routine assessment of patients presenting with new onset focal hyperhidrosis of pelvis, buttocks, and upper thighs. Timely urological referral should be made for all male patients with recurrent UTI. To the authors' knowledge, there have been no other reports of UTI-associated focal hyperhidrosis. PMID:27379188

  12. A Micro-Thermal Sensor for Focal Therapy Applications

    NASA Astrophysics Data System (ADS)

    Natesan, Harishankar; Hodges, Wyatt; Choi, Jeunghwan; Lubner, Sean; Dames, Chris; Bischof, John

    2016-02-01

    There is an urgent need for sensors deployed during focal therapies to inform treatment planning and in vivo monitoring in thin tissues. Specifically, the measurement of thermal properties, cooling surface contact, tissue thickness, blood flow and phase change with mm to sub mm accuracy are needed. As a proof of principle, we demonstrate that a micro-thermal sensor based on the supported “3ω” technique can achieve this in vitro under idealized conditions in 0.5 to 2 mm thick tissues relevant to cryoablation of the pulmonary vein (PV). To begin with “3ω” sensors were microfabricated onto flat glass as an idealization of a focal probe surface. The sensor was then used to make new measurements of ‘k’ (W/m.K) of porcine PV, esophagus, and phrenic nerve, all needed for PV cryoabalation treatment planning. Further, by modifying the sensor use from traditional to dynamic mode new measurements related to tissue vs. fluid (i.e. water) contact, fluid flow conditions, tissue thickness, and phase change were made. In summary, the in vitro idealized system data presented is promising and warrants future work to integrate and test supported “3ω” sensors on in vivo deployed focal therapy probe surfaces (i.e. balloons or catheters).

  13. Signal processing of microbolometer infrared focal-plane arrays

    NASA Astrophysics Data System (ADS)

    Zhang, Junju; Qian, Yunsheng; Chang, Benkang; Xing, Suxia; Sun, Lianjun

    2005-01-01

    A 320×240-uncooled-microbolometer-based signal processing circuit for infrared focal-plane arrays is presented, and the software designs of this circuit system are also discussed in details. This signal processing circuit comprises such devices as FPGA, D/A, A/D, SRAM, Flash, DSP, etc., among which, FPGA is the crucial part, which realizing the generation of drive signals for infrared focal-plane, nonuniformity correction, image enhancement and video composition. The device of DSP, mainly offering auxiliary functions, carries out communication with PC and loads data when power-up. The phase locked loops (PLL) is used to generate high-quality clocks with low phase dithering and multiple clocks are to used satisfy the demands of focal-plane arrays, A/D, D/A and FPGA. The alternate structure is used to read or write SRAM in order to avoid the contradiction between different modules. FIFO embedded in FPGA not only makes full use of the resources of FPGA but acts as the channel between different modules which have different-speed clocks. What's more, working conditions, working process, physical design and management of the circuit are discussed. In software designing, all the function modules realized by FPGA and DSP devices, which are mentioned in the previous part, are discussed explicitly. Particularly to the nonuniformity correction module, the pipeline structure is designed to improve the working frequency and the ability to realize more complex algorithm.

  14. Focal Adhesion Assembly Induces Phenotypic Changes and Dedifferentiation in Chondrocytes.

    PubMed

    Shin, Hyunjun; Lee, Mi Nam; Choung, Jin Seung; Kim, Sanghee; Choi, Byung Hyune; Noh, Minsoo; Shin, Jennifer H

    2016-08-01

    The expansion of autologous chondrocytes in vitro is used to generate sufficient populations for cell-based therapies. However, during monolayer culture, chondrocytes lose inherent characteristics and shift to fibroblast-like cells as passage number increase. Here, we investigated passage-dependent changes in cellular physiology, including cellular morphology, motility, and gene and protein expression, as well as the role of focal adhesion and cytoskeletal regulation in the dedifferentiation process. We found that the gene and protein expression levels of both the focal adhesion complex and small Rho GTPases are upregulated with increasing passage number and are closely linked to chondrocyte dedifferentiation. The inhibition of focal adhesion kinase (FAK) but not small Rho GTPases induced the loss of fibroblastic traits and the recovery of collagen type II, aggrecan, and SOX9 expression levels in dedifferentiated chondrocytes. Based on these findings, we propose a strategy to suppress chondrogenic dedifferentiation by inhibiting the identified FAK or Src pathways while maintaining the expansion capability of chondrocytes in a 2D environment. These results highlight a potential therapeutic target for the treatment of skeletal diseases and the generation of cartilage in tissue-engineering approaches. J. Cell. Physiol. 231: 1822-1831, 2016. © 2015 Wiley Periodicals, Inc. PMID:26661891

  15. Focal Cortical Dysplasia (FCD) lesion analysis with complex diffusion approach.

    PubMed

    Rajan, Jeny; Kannan, K; Kesavadas, C; Thomas, Bejoy

    2009-10-01

    Identification of Focal Cortical Dysplasia (FCD) can be difficult due to the subtle MRI changes. Though sequences like FLAIR (fluid attenuated inversion recovery) can detect a large majority of these lesions, there are smaller lesions without signal changes that can easily go unnoticed by the naked eye. The aim of this study is to improve the visibility of focal cortical dysplasia lesions in the T1 weighted brain MRI images. In the proposed method, we used a complex diffusion based approach for calculating the FCD affected areas. Based on the diffused image and thickness map, a complex map is created. From this complex map; FCD areas can be easily identified. MRI brains of 48 subjects selected by neuroradiologists were given to computer scientists who developed the complex map for identifying the cortical dysplasia. The scientists were blinded to the MRI interpretation result of the neuroradiologist. The FCD could be identified in all the patients in whom surgery was done, however three patients had false positive lesions. More lesions were identified in patients in whom surgery was not performed and lesions were seen in few of the controls. These were considered as false positive. This computer aided detection technique using complex diffusion approach can help detect focal cortical dysplasia in patients with epilepsy. PMID:19560319

  16. Stability of focal adhesion enhanced by its inner force fluctuation

    NASA Astrophysics Data System (ADS)

    Mao, Zhi-Xiu; Chen, Xiao-Feng; Chen, Bin

    2015-08-01

    Cells actively sense and respond to mechanical signals from the extracellular matrix through focal adhesions. By representing a single focal adhesion as a cluster of slip bonds, it has been demonstrated that the cluster often became unstable under fluctuated forces. However, an unusual case was also reported, where the stability of the cluster might be substantially enhanced by a fluctuated force with a relatively low fluctuation frequency and high fluctuation amplitude. Such an observation cannot be explained by the conventional fracture theory of fatigue. Here, we intensively investigate this intriguing observation by carrying out systematic parametric studies. Our intensive simulation results indicate that stability enhancement of this kind is in fact quite robust, which can be affected by the stochastic features of a single bond and the profile of the fluctuated forces such as the average value of bond force. We then suggest that the fluctuation of traction force within a focal adhesion might enhance its stability in a certain way. Project supported by the National Natural Science Foundation of China (Grant No.*11372279).

  17. Focal and abnormally persistent paralysis associated with congenital paramyotonia

    PubMed Central

    Magot, Armelle; David, Albert; Sternberg, Damien; Péréon, Yann

    2014-01-01

    Mutations of the skeletal muscle voltage-gated sodium channel (NaV1.4) are an established cause of several clinically distinct forms of periodic paralysis and myotonia. Focal paresis has sometimes already been described. We report a case with atypical clinical manifestation comprising paramyotonia and cold-induced persistent and focal paralysis. A 27-year-old woman presented with paramyotonia congenita since her childhood. She experienced during her childhood one brief episode of generalised weakness. At the age of 27, she experienced a focal paresis lasting for several months. The known mutation p.Val1293Ile was found in the muscle sodium channel gene (SCN4A). Channel inactivation is involved in most Na+ channelopathies. Fast inactivation is known to be responsible for the myotonia phenotype. We hypothesise that the V1293I mutation may also alter the slow inactivation in specific conditions, for example, prolonged cold exposure or prolonged and intensive exercise. This observation broadens the spectrum of clinical manifestations of this sodium channel mutation. PMID:24939454

  18. Neuronal polarity selection by topography-induced focal adhesion control.

    PubMed

    Ferrari, Aldo; Cecchini, Marco; Serresi, Michela; Faraci, Paolo; Pisignano, Dario; Beltram, Fabio

    2010-06-01

    Interaction between differentiating neurons and the extracellular environment guides the establishment of cell polarity during nervous system development. Developing neurons read the physical properties of the local substrate in a contact-dependent manner and retrieve essential guidance cues. In previous works we demonstrated that PC12 cell interaction with nanogratings (alternating lines of ridges and grooves of submicron size) promotes bipolarity and alignment to the substrate topography. Here, we investigate the role of focal adhesions, cell contractility, and actin dynamics in this process. Exploiting nanoimprint lithography techniques and a cyclic olefin copolymer, we engineered biocompatible nanostructured substrates designed for high-resolution live-cell microscopy. Our results reveal that neuronal polarization and contact guidance are based on a geometrical constraint of focal adhesions resulting in an angular modulation of their maturation and persistence. We report on ROCK1/2-myosin-II pathway activity and demonstrate that ROCK-mediated contractility contributes to polarity selection during neuronal differentiation. Importantly, the selection process confined the generation of actin-supported membrane protrusions and the initiation of new neurites at the poles. Maintenance of the established polarity was independent from NGF stimulation. Altogether our results imply that focal adhesions and cell contractility stably link the topographical configuration of the extracellular environment to a corresponding neuronal polarity state. PMID:20304485

  19. [A case of focal epilepsy manifesting multiple psychiatric auras].

    PubMed

    Ezura, Michinori; Kakisaka, Yosuke; Jin, Kazutaka; Kato, Kazuhiro; Iwasaki, Masaki; Fujikawa, Mayu; Aoki, Masashi; Nakasato, Nobukazu

    2015-01-01

    We present a case of epilepsy with multiple types of focal seizures that were misdiagnosed as psychiatric disorders. A 20-year-old female patient presented with a variety of episodes, including loss of consciousness, deja vu, fear, delusion of possession, violent movements, and generalized convulsions. Each of these symptoms appeared in a stereotypic manner. She was initially diagnosed with a psychiatric disorder and treated with psychoactive medications, which had no effect. Long-term video electroencephalography revealed that her episodes of violent movement with impaired consciousness and secondarily generalized seizure were epileptic events originating in the right hemisphere. High-field brain magnetic resonance imaging for detecting subtle lesions revealed bilateral lesions from periventricular nodular heterotopia. Her final diagnosis was right hemispheric focal epilepsy. Carbamazepine administration was started, which successfully controlled all seizures. The present case demonstrates the pitfall of diagnosing focal epilepsy when it presents with multiple types of psychiatric aura. Epilepsy should thus be included in differential diagnoses, considering the stereotypic nature of symptoms, to avoid misdiagnosis. PMID:25585440

  20. Dynamin Regulates Focal Exocytosis in Phagocytosing MacrophagesV⃞

    PubMed Central

    Di, Anke; Nelson, Deborah J.; Bindokas, Vytautas; Brown, Mary E.; Libunao, Frances; Palfrey, H. Clive

    2003-01-01

    Phagocytosis in macrophages is thought to involve insertion of cytoplasmic vesicles at sites of membrane expansion before particle ingestion (“focal” exocytosis). Capacitance (Cm) measurements of cell surface area were biphasic, with an initial rise indicative of exocytosis followed by a fall upon phagocytosis. Unlike other types of regulated exocytosis, the Cm rise was insensitive to intracellular Ca2+, but was inhibited by guanosine 5′-O-(2-thio)diphosphate. Particle uptake, but not Cm rise, was affected by phosphatidylinositol 3-kinase inhibitors. Inhibition of actin polymerization eliminated the Cm rise, suggesting possible coordination between actin polymerization and focal exocytosis. Introduction of anti-pan-dynamin IgG blocked Cm changes, suggesting that dynamin controls focal exocytosis and thereby phagocytosis. Similarly, recombinant glutathione S-transferase•amphiphysin-SH3 domain, but not a mutated form that cannot bind to dynamin, inhibited both focal exocytosis and phagocytosis. Immunochemical analysis of endogenous dynamin distribution in macrophages revealed a substantial particulate pool, some of which localized to a presumptive endosomal compartment. Expression of enhanced green fluorescent protein•dynamin-2 showed a motile dynamin pool, a fraction of which migrated toward and within the phagosomal cup. These results suggest that dynamin is involved in the production and/or movement of vesicles from an intracellular organelle to the cell surface to support membrane expansion around the engulfed particle. PMID:12802072

  1. A Micro-Thermal Sensor for Focal Therapy Applications

    PubMed Central

    Natesan, Harishankar; Hodges, Wyatt; Choi, Jeunghwan; Lubner, Sean; Dames, Chris; Bischof, John

    2016-01-01

    There is an urgent need for sensors deployed during focal therapies to inform treatment planning and in vivo monitoring in thin tissues. Specifically, the measurement of thermal properties, cooling surface contact, tissue thickness, blood flow and phase change with mm to sub mm accuracy are needed. As a proof of principle, we demonstrate that a micro-thermal sensor based on the supported “3ω” technique can achieve this in vitro under idealized conditions in 0.5 to 2 mm thick tissues relevant to cryoablation of the pulmonary vein (PV). To begin with “3ω” sensors were microfabricated onto flat glass as an idealization of a focal probe surface. The sensor was then used to make new measurements of ‘k’ (W/m.K) of porcine PV, esophagus, and phrenic nerve, all needed for PV cryoabalation treatment planning. Further, by modifying the sensor use from traditional to dynamic mode new measurements related to tissue vs. fluid (i.e. water) contact, fluid flow conditions, tissue thickness, and phase change were made. In summary, the in vitro idealized system data presented is promising and warrants future work to integrate and test supported “3ω” sensors on in vivo deployed focal therapy probe surfaces (i.e. balloons or catheters). PMID:26916460

  2. Focal Hyperhidrosis Associated with Recurrent Urinary Tract Infections.

    PubMed

    Ismail, Dina; Madhwapathi, Vidya; Ladoyanni, Evmorfia

    2016-01-01

    Hyperhidrosis affects almost 3% of the population and is characterized by sweating that occurs in excess of that needed for normal thermoregulation. It can occur as a primary disease or secondary to underlying clinical conditions. Hyperhidrosis can stem from neurogenic sympathetic over activity involving normal eccrine glands. We report the interesting case of a 75-year-old male patient with a 6-month history of new onset secondary focal hyperhidrosis of buttocks, pelvis, and upper thighs. Each time his symptoms worsened he was found to have culture positive urine samples for Escherichia coli (E. coli). He underwent urological investigation and was found to have urethral strictures and cystitis. The hyperhidrosis improved each time his urinary tract infection (UTI) was treated with antibiotics and continued to remain stable with a course of prophylactic trimethoprim. We hypothesize that the patient's urethral strictures led to inhibition in voiding which in turn increased the susceptibility to UTIs. Accumulation of urine and increased bladder pressure in turn raised sympathetic nerve discharge leading to excessive sweating. We recommend that a urine dip form part of the routine assessment of patients presenting with new onset focal hyperhidrosis of pelvis, buttocks, and upper thighs. Timely urological referral should be made for all male patients with recurrent UTI. To the authors' knowledge, there have been no other reports of UTI-associated focal hyperhidrosis. PMID:27379188

  3. Writer’s cramp: is focal dystonia the best explanation?

    PubMed Central

    Pritchard, Michael H

    2013-01-01

    Often considered no more than an historical curiosity, writer’s cramp remains an important disability in the workplace and the mechanism, which has puzzled the best medical minds for generations, remains contentious. A remarkable range of hypotheses has been put forward to try and explain a disability which periodically reached epidemic and economically worrying levels, but in the end medical opinion has accepted the explanation put forward by neurologists Sheehy and Marsden in 1983 that this was caused by a form of focal dystonia. However, the majority of the historical descriptions of writer’s cramp do not fit the classical parameters of focal dystonia and are more accurately described as a progressive forearm muscle fatigue. Today’s keyboard operators continue to complain of symptoms identical to their clerical forebears demonstrating that this is a problem which has evolved but not disappeared; this has the paradoxical advantage that modern research techniques enable this complaint to be revisited. The result shows that two varieties of writer’s cramp have always existed and while focal dystonia remains a valid explanation for a minority of cases, the much more common fatigue-based complaint is better explained by chronic compartment syndrome of the forearm. PMID:23885297

  4. The impact of focal spot size on clinical images

    NASA Astrophysics Data System (ADS)

    Gorham, Sinead M.; Brennan, Patrick C.

    2009-02-01

    The physical assessment of the spatial resolution produced by broad and fine focal spot sizes has been well established. There is however an evident lack of study into the impact of focal spot selection on clinical image quality. While the excessive use of the fine focus has an impact on tube life, the benefit of its use in radiological imaging should be investigated. Cadaver images were produced in order to compare the 0.8mm and 1.8mm focal spot sizes. The range of radiographic projections assessed included the medio-lateral ankle, antero-posterior (AP) knee, AP thoracic spine and horizontal beam lateral (HBL) lumbar spine. Five clinicians analysed the images using a 1 - 4 visual grading analysis score against a reference image to assess the visibility of specific anatomical criteria. A Mann- Whitney U statistical test was employed to assess the results. No significant statistical differences between the scores for the broad and fine focus images were found, although a non-significant higher score in image quality was shown for the fine compared with the broad focus images with large object to detector distance. No difference in image quality was shown for examinations traditionally produced with a fine focus. The study results questions the wide spread usage of fine foci for specific examinations, particularly for extremity examinations. Current practice based on international guidelines can lead to a reduced life and increased cost with little clinical benefit.

  5. Automatic location of microscopic focal planes for computerized stereology

    NASA Astrophysics Data System (ADS)

    Elozory, Daniel T.; Bonam, Om Pavithra; Kramer, Kurt; Goldgof, Dmitry B.; Hall, Lawrence O.; Mangual, Osvaldo; Mouton, Peter R.

    2011-03-01

    When applying design-based stereology to biological tissue, there are two primary applications for an auto-focusing function in the software of computerized stereology system. The system must first locate the in-focus optical planes at the upper and lower surfaces of stained tissue sections, thus identifying the top and bottom as well as the thickness of the tissue. Second, the system must find the start and end along the Z-axis of stained objects within a Z-stack of images through tissue sections. In contrast to traditional autofocus algorithms that seek a global maximum or peak on the focus curve, the goal of this study was to find the two "knees" of the focus curve that represent the "just out-of-focus" focal planes. The upper surface of the tissue section is defined as the image just before focus is detected moving down the Z-stack. Continuing down, the lower surface is defined as the first image of the last set of adjacent images where focus is no longer detected. The performance of seven focus algorithms in locating the top and bottom focal planes of tissue sections was analyzed by comparing each algorithm on 34 Z-stacks including a total of 828 images. The Thresholded Absolute Gradient algorithm outperformed all others, correctly identifying the top or bottom focal plane within an average of 1 μm on the training data as well as the test data.

  6. Multiplicative and subtractive focal volume engineering in coherent Raman microscopy

    PubMed Central

    Raghunathan, Varun; Potma, Eric Olaf

    2012-01-01

    Rigorous calculations are performed to study the effective reduction of the nonlinear excitation volumes when using phase-only masks to condition the pump and Stokes driving fields. Focal volume reduction was achieved using both a multiplicative operation of the excitation fields as well as a subtractive operation. Using a tunable optical bottle beam for the Stokes field, an effective reduction of the width of the excitation volume by a factor of 1.5 can be achieved in the focal plane. Further reduction of the focal volume introduces a rapid growth of sidelobes, which renders such volumes unsuitable for imaging applications. In addition, phase sensitive detection was found to provide information from selective sub-divisions of the engineered coherent anti-Stokes Raman scattering excitation volume. In the case of isolated nanoparticles, an apparent resolution improvement by a factor of 3 is demonstrated, and it is shown that the size of sub-diffraction-limited particles can be accurately determined using phase sensitive detection. PMID:21045900

  7. Achromatic Focal Plane Mask for Exoplanet Imaging Coronagraphy

    NASA Technical Reports Server (NTRS)

    Newman, Kevin Edward; Belikov, Ruslan; Guyon, Olivier; Balasubramanian, Kunjithapatham; Wilson, Dan

    2013-01-01

    Recent advances in coronagraph technologies for exoplanet imaging have achieved contrasts close to 1e10 at 4 lambda/D and 1e-9 at 2 lambda/D in monochromatic light. A remaining technological challenge is to achieve high contrast in broadband light; a challenge that is largely limited by chromaticity of the focal plane mask. The size of a star image scales linearly with wavelength. Focal plane masks are typically the same size at all wavelengths, and must be sized for the longest wavelength in the observational band to avoid starlight leakage. However, this oversized mask blocks useful discovery space from the shorter wavelengths. We present here the design, development, and testing of an achromatic focal plane mask based on the concept of optical filtering by a diffractive optical element (DOE). The mask consists of an array of DOE cells, the combination of which functions as a wavelength filter with any desired amplitude and phase transmission. The effective size of the mask scales nearly linearly with wavelength, and allows significant improvement in the inner working angle of the coronagraph at shorter wavelengths. The design is applicable to almost any coronagraph configuration, and enables operation in a wider band of wavelengths than would otherwise be possible. We include initial results from a laboratory demonstration of the mask with the Phase Induced Amplitude Apodization coronagraph.

  8. On-chip ADC for infrared focal plane arrays

    NASA Astrophysics Data System (ADS)

    Gao, Lei; Chen, Guo-qiang; Wang, Pan; Ding, Rui-jun

    2013-09-01

    This paper presents a low power and small area analog-digital converter (ADC) for infrared focal plane arrays (IRFPA) readout integrated circuit (ROIC). Successive approximation register (SAR) ADC architecture is used in this IRFPA readout integrated circuit. Each column of the IRFPA shares one SAR ADC. The most important part is the three-level DAC. Compared to the previous design, this three-level DAC needs smaller area, has lower power, and more suitable for IRFPA ROIC. In this DAC, its most significant bit (MSB) sub-DAC uses charge scaling, while the least significant bit (LSB) sub-DAC uses voltage scaling. Where the MSB sub-DAC consists of a four-bit charge scaling DAC and a five-bit sub-charge scaling DAC. We need to put a scaling capacitor Cs between these two sub-DACs. Because of the small area, we have more design methods to make the ADC has a symmetrical structure and has higher accuracy. The ADC also needs a high resolution comparator. In this design the comparator uses three-stage operational amplifier structure to have a 77dB differential gain. As the IR focal plane readout circuit signal is stepped DC signal, the circuit design time without adding the sample and hold circuit, so we can use a DC signal instead of infrared focal plane readout circuit output analog signals to be simulated. The simulation result shows that the resolution of the ADC is 12 bit.

  9. Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

    PubMed Central

    Lee, Daniel A.; Salvatierra, Juan; Velarde, Esteban; Wong, John; Ford, Eric C.; Blackshaw, Seth

    2013-01-01

    The functional characterization of adult-born neurons remains a significant challenge. Approaches to inhibit adult neurogenesis via invasive viral delivery or transgenic animals have potential confounds that make interpretation of results from these studies difficult. New radiological tools are emerging, however, that allow one to noninvasively investigate the function of select groups of adult-born neurons through accurate and precise anatomical targeting in small animals. Focal ionizing radiation inhibits the birth and differentiation of new neurons, and allows targeting of specific neural progenitor regions. In order to illuminate the potential functional role that adult hypothalamic neurogenesis plays in the regulation of physiological processes, we developed a noninvasive focal irradiation technique to selectively inhibit the birth of adult-born neurons in the hypothalamic median eminence. We describe a method for Computer tomography-guided focal irradiation (CFIR) delivery to enable precise and accurate anatomical targeting in small animals. CFIR uses three-dimensional volumetric image guidance for localization and targeting of the radiation dose, minimizes radiation exposure to nontargeted brain regions, and allows for conformal dose distribution with sharp beam boundaries. This protocol allows one to ask questions regarding the function of adult-born neurons, but also opens areas to questions in areas of radiobiology, tumor biology, and immunology. These radiological tools will facilitate the translation of discoveries at the bench to the bedside. PMID:24300415

  10. Energy Reconstruction with the Sweeper Magnet Focal Plane Detector

    NASA Astrophysics Data System (ADS)

    Hitt, George; Thoennessen, Michael; Frank, Nathan; Cooper, Matt; Vander Molen, A. M.; Nett, Brian

    2002-10-01

    The Sweeper Magnet Focal Plane Detector project is a collaboration of the National High Magnetic Field Laboratory (NHMFL) at Florida State University and the National Superconducting Cyclotron Laboratory (NSCL) at Michigan State University. The NHMFL will construct the Sweeper Magnet, a large C-type magnet necessary for the bending of rigid nuclear beams. The NSCL will build the Focal Plane Detectors consisting of two Cathode Readout Drift Detectors (CRDCs) for taking precise position measurements and an Ion Chamber with plastic scintillators for taking ΔE and E_tot measurements. During beam experiments, the Sweeper Magnet will bend the charged fragments for detection in the Focal Plane Detector. As fragments pass through, each CRDC will measure a position where fragments impinge. This will allow experimenters to calculate a fragment's trajectory and determine where it will strike the large stopping scintillator for the E_tot measurements. In order to obtain accurate energies of the fragments, the position sensitivity of the large scintillator must be mapped. By finding a functional relationship between the position of the impinging particles and the attenuation of the light emitted by the scintillator, one can use the known position information from the CRDCs to reconstruct the energy of fragments. The position sensitivity of the large plastic scintillator as measured with a collimated, pulsed blue diode will be presented.

  11. Focal nodular hyperplasia of the liver: a link with sickle cell disease?

    PubMed Central

    Heaton, N D; Pain, J; Cowan, N C; Salisbury, J; Howard, E R

    1991-01-01

    Focal nodular hyperplasia is a benign liver tumour that is rare in children. We report the second case of a child with sickle cell disease presenting with symptomatic focal nodular hyperplasia. The possible pathogenesis of focal nodular hyperplasia and the association with sickle cell disease are discussed. Images Figure 1 Figure 2 Figure 3 PMID:1929517

  12. Measurement of optical modulation functions in sparsely sampled mosaic focal plane arrays

    NASA Technical Reports Server (NTRS)

    Young, J. B.; Thurlow, P. E.

    1982-01-01

    It is pointed out that the measurement of optical modulation functions for detectors in focal plane arrays may be somewhat more difficult under 'full-up' systems conditions as compared to ideal laboratory conditions. An idealized optical modulation test arrangement is considered along with a full-up scanned system involving an earth mapper in polar orbit. In testing the system in full-up condition, a problem arises with respect to the acquisition of knife edge response data. In order to overcome this problem, a preferred method is developed for obtaining KER data on a single scan. A special 'phased edge' reticle is developed for use in the test set-up. Attention is given to aspects of knife edge reconstruction.

  13. Low dark current LWIR HgCdTe focal plane arrays at AIM

    NASA Astrophysics Data System (ADS)

    Haiml, M.; Eich, D.; Fick, W.; Figgemeier, H.; Hanna, S.; Mahlein, M.; Schirmacher, W.; Thöt, R.

    2016-05-01

    Cryogenically cooled HgCdTe (MCT) quantum detectors are unequalled for applications requiring high imaging as well as high radiometric performance in the infrared spectral range. Compared with other technologies, they provide several advantages, such as the highest quantum efficiency, lower power dissipation compared to photoconductive devices, and fast response times, hence outperforming micro-bolometer arrays. AIM will present its latest results on n-on-p as well as p-on-n low dark current planar MCT photodiode focal plane detector arrays at cut-off wavelengths >11 μm at 80 K. Dark current densities below the Rule'07 have been demonstrated for n-on-p devices. Slightly higher dark current densities and excellent cosmetics with very low cluster and point defect densities have been demonstrated for p-on-n devices.

  14. Relative performance of filled and feedhorn-coupled focal-plane architectures.

    PubMed

    Griffin, Matthew J; Bock, James J; Gear, Walter K

    2002-11-01

    Modern far-infrared and submillimeter instruments require large-format arrays. We consider the relative performance of filled-array (bare pixel) and feedhorn-coupled architectures for bolometer focal planes. Based on typical array parameters, we quantify the relative observing speeds and comment on the merits of the different architectures. Filled arrays can provide higher mapping speed (by a factor of as much as 3.5) and simpler observing modes at the expense of reduced sensitivity for pointed observations, increased detector numbers, and greater vulnerability to stray light and electromagnetic interference. Taking advantage of the filled-array architecture requires strongly background-limited detectors. At millimeter wavelengths, filled arrays must be surrounded by a sufficiently cold enclosure to minimize the background power from the instrument itself. PMID:12412645

  15. Identification and classification of chemicals using terahertz reflective spectroscopic focal-plane imaging system

    NASA Astrophysics Data System (ADS)

    Zhong, Hua; Redo-Sanchez, Albert; Zhang, X.-C.

    2006-10-01

    We present terahertz (THz) reflective spectroscopic focal-plane imaging of four explosive and bio-chemical materials (2, 4-DNT, Theophylline, RDX and Glutamic Acid) at a standoff imaging distance of 0.4 m. The 2 dimension (2-D) nature of this technique enables a fast acquisition time and is very close to a camera-like operation, compared to the most commonly used point emission-detection and raster scanning configuration. The samples are identified by their absorption peaks extracted from the negative derivative of the reflection coefficient respect to the frequency (-dr/dv) of each pixel. Classification of the samples is achieved by using minimum distance classifier and neural network methods with a rate of accuracy above 80% and a false alarm rate below 8%. This result supports the future application of THz time-domain spectroscopy (TDS) in standoff distance sensing, imaging, and identification.

  16. Characterization of an advanced focal plane for multispectral linear array (MLA) application

    NASA Technical Reports Server (NTRS)

    King, P.; Botts, S.; Orias, G.; Yang, H. B.

    1984-01-01

    It is pointed out that the MLA instrument represents the next generation in the Landsat series of earth resources satellites. The MLA sensor concept utilizes a pushbroom scan mode to eliminate electromechanical scan mirrors, and the lower reliabililty and higher power dissipation which accompany their employment. The pushbroom scanner makes use of a linear array which consists generally of thousands of detectors oriented perpendicular to the along-track direction of the satellite. Test techniques have been developed for the measurement of the module parameters which are critical to MLA focal plane performance. These measurements include the determination of infrared responsivity, linearity over the dynamic range, temporal noise, and fixed pattern effects on each detector element of each module tested. Tests related to spectral response, crosstalk, and spot scan profiles are also conducted. A description is provided of the test equipment involved.

  17. Case Presentation of Concomitant and Contiguous Adenomatoid Odontogenic Tumor and Focal Cemento-Ossifying Dysplasia

    PubMed Central

    Rezvani, Gita; Donoghue, Mandana; Reichart, Peter A; Pazuhi, Neda

    2015-01-01

    A 24 year-old male was presented for the diagnosis of an asymptomatic bony expansion in relation to the right maxillary canine and first premolar. The unilocular radiolucent lesion with central foci of calcification had caused divergence of canine and first premolar roots without any resorption. This case report details a diagnosis of two distinct disease processes of different cellular origin namely, focal cemento-ossifying dysplasia and adenomatoid odontogenic tumor in a previously unreported concomitant and contiguous relationship. The diagnosis was determined by a combination of clinical, radiographic, histopathological and surgical evidence. This case highlights two points, first the need to examine all mixed radiolucent-radiopaque lesions with advanced imaging techniques to assess the number and extent of the lesions prior to treatment planning. Second a likely role of periodontal ligament as the tissue source for odontogenic epithelial cells and mesenchymal stem cells required for the development of odontogenic tumors and cemento-osseous dysplasias. PMID:26464605

  18. Measurement of the migration of a focal knee resurfacing implant with radiostereometry

    PubMed Central

    2014-01-01

    Background and purpose Articular resurfacing metal implants have been developed to treat full-thickness localized articular cartilage defects. Evaluation of the fixation of these devices is mandatory. Standard radiostereometry (RSA) is a validated method for evaluation of prosthetic migration, but it requires that tantalum beads are inserted into the implant. For technical reasons, this is not possible for focal articular resurfacing components. In this study, we therefore modified the tip of an articular knee implant and used it as a marker for RSA, and then validated the method. Material and methods We modified the tip of a resurfacing component into a hemisphere with a radius of 3 mm, marked it with a 1.0-mm tantalum marker, and implanted it into a sawbone marked with 6 tantalum beads. Point-motion RSA of the “hemisphere bead” using standard automated RSA as the gold standard was compared to manual measurement of the tip hemisphere. 20 repeated stereograms with gradual shifts of position of the specimen between each double exposure were used for the analysis. The tip motion was compared to the point motion of the hemisphere bead to determine the accuracy and precision. Results The accuracy of the manual tip hemisphere method was 0.08–0.19 mm and the precision ranged from 0.12 mm to 0.33 mm. Interpretation The accuracy and precision for translations is acceptable when using a small hemisphere at the tip of a focal articular knee resurfacing implant instead of tantalum marker beads. Rotations of the implant cannot be evaluated. The method is accurate and precise enough to allow detection of relevant migration, and it will be used for future clinical trials with the new implant. PMID:24286562

  19. Curved-Focal-Plane Arrays Using Deformed-Membrane Photodetectors

    NASA Technical Reports Server (NTRS)

    Nikzad, Shouleh; Jones, Todd

    2004-01-01

    A versatile and simple approach to the design and fabrication of curved-focal-plane arrays of silicon-based photodetectors is being developed. This approach is an alternative to the one described in "Curved Focal-Plane Arrays Using Back- Illuminated High-Purity Photodetectors" (NPO-30566), NASA Tech Briefs, Vol. 27, No. 10 (October 2003), page 10a. As in the cited prior article, the basic idea is to improve the performance of an imaging instrument and simplify the optics needed to obtain a given level of performance by making an image sensor (in this case, an array of photodetectors) conform to a curved focal surface, instead of designing the optics to project an image onto a flat focal surface. There is biological precedent for curved-focal-surface designs: retinas - the image sensors in eyes - conform to the naturally curved focal surfaces of eye lenses. The present approach is applicable to both front-side- and back-side-illuminated, membrane photodetector arrays and is being demonstrated on charge-coupled devices (CCDs). The very-large scale integrated (VLSI) circuitry of such a CCD or other array is fabricated on the front side of a silicon substrate, then the CCD substrate is attached temporarily to a second substrate for mechanical support, then material is removed from the back to obtain the CCD membrane, which typically has a thickness between 10 and 20 m. In the case of a CCD designed to operate in back-surface illumination, delta doping can be performed after thinning to enhance the sensitivity. This approach is independent of the design and method of fabrication of the front-side VLSI circuitry and does not involve any processing of a curved silicon substrate. In this approach, a third substrate would be prepared by polishing one of its surfaces to a required focal-surface curvature. A CCD membrane fabricated as described above would be pressed against, deformed into conformity with, and bonded to, the curved surface. The technique used to press and

  20. Neuroprotection of Sanhua Decoction against Focal Cerebral Ischemia/Reperfusion Injury in Rats through a Mechanism Targeting Aquaporin 4

    PubMed Central

    Lu, Lin; Li, Hui-qin; Li, Ji-huang; Liu, Ai-ju

    2015-01-01

    Sanhua decoction (SHD) is a famous classic Chinese herbal prescription for ischemic stroke, and aquaporin 4 (AQP4) is reported to play a key role in ischemic brain edema. This study aimed to investigate neuroprotection of SHD against focal cerebral ischemia/reperfusion (I/R) injury in rats and explore the hypothesis that AQP4 probably is the target of SHD neuroprotection against I/R rats. Lentiviral-mediated AQP4-siRNA was inducted into adult male Sprague-Dawley rats via intracerebroventricular injection. The focal cerebral ischemia/reperfusion model was established by occluding middle cerebral artery. Neurological examinations were performed according to Longa Scale. Brain water content, was determined by wet and dry weight measurement. Western blot was adopted to test the AQP4 expression in ipsilateral hippocampus. After the treatment, SHD alleviated neurological deficits, reduced brain water content and downregulated the expression of AQP4 at different time points following I/R injury. Furthermore, neurobehavioral function and brain edema after I/R were significantly attenuated via downregulation of AQP4 expression when combined with AQP4-siRNA technology. In conclusion, SHD exerted neuroprotection against focal cerebral I/R injury in rats mainly through a mechanism targeting AQP4. PMID:26089944

  1. Proliferative re-modeling of the spatial organization of human superficial chondrocytes distant to focal early osteoarthritis (OA)

    PubMed Central

    Rolauffs, Bernd; Williams, James M.; Aurich, Matthias; Grodzinsky, Alan J.; Kuettner, Klaus E.; Cole, Ada A.

    2010-01-01

    Objective Human superficial chondrocytes show distinct spatial organizations whereas they commonly aggregate near osteoarthritic (OA) fissures. It is not known whether remodeling or destruction of the spatial chondrocyte organization may occur distant to focal (early) OA lesions. Methods The intact cartilages (condyles, patellofemoral groove, proximal tibia) distant to focal OA lesions of human grade 2 joints were compared to location-matched non-degenerative (grade 0–1) cartilages. Chondrocyte nuclei were stained with propidium iodide and recorded by fluorescence-microscopy in a top-down view. Chondrocyte arrangements were tested for randomness or significant grouping via point pattern analyses (Clark and Evans Aggregation Index), and were correlated with OA grade and surface cell densities. Results In grade 2 cartilages, superficial chondrocytes were situated in horizontal patterns such as strings, cluster, pairs and singles comparable to non-degenerative cartilage. In the intact cartilages of grade 2 joints, the spatial organization included a novel pattern, consisting of chondrocytes that were aligned in two parallel lines building double strings. These double strings correlated with an increased number of chondrocytes per group (p<0.05), increased corresponding superficial zone cell density (p<0.001), and were observed in all grade 2 condyles (p<0.001), some grade 2 tibiae (p<0.05) but never in grade 0–1 cartilage (p<0.001). Conclusion The present study is the first to identify a distinct spatial re-organization of human superficial chondrocytes in response to distant early OA lesions and suggests that proliferation had occurred distant to focal early OA. This spatial re-organization may serve to recruit metabolically active units as attempt to repair focal damage. PMID:20112377

  2. MOSAD IR focal plane per pixel A/D development

    NASA Astrophysics Data System (ADS)

    Mandl, William J.; Kennedy, James J.; Chu, Muren

    1996-06-01

    An on focal plane digital readout development suggested by the Army Night Vision & Electronics Sensors Directorate is proceeding under a combined program with the development of two color HCT detector arrays. The on focal plane A/D process is based on the Amain patented multiplexed oversample A/D, MOSAD, technology. In the first year of the program, prototype on focal plane analog to digital converters for both staring arrays and scanning arrays were built and demonstrated. The prototypes included a 2 loop double ended switched MOSAD and a 1 loop single ended MOSAD. Results from the original experimental prototypes showed conclusively that better than 14 bits could be achieved and that well capacity could be increased to support high background HCT needs approaching 10(superscript 9) electrons. In the second year, a 64 X 64 staring array for HCT LWIR detectors, 50 micron centers, was built based on these original prototype designs. The layout of the per pixel MOSAD A/D staring array used Orbit 1.2 micron CMOS process and achieved a pixel size of 40 microns with a well capacity of 1.9 X 10(superscript 8) electrons. Integration capacitors were built using Orbit's normal double poly capacitors with a standard buffered direct inject TIA detector interface configuration. Preliminary testing has been completed indicating complete functionality. Fermionics LWIR HCT detectors with cutoff at 9 microns have been built for attachment to the readout but indium bumping was not completed in time to report system level testing results. However, some noise tests have been performed using on array current mirrors. These tests indicate that better than 12 bits has been achieved, but lower noise current sources will be required for a more accurate measurement.

  3. Temperament and character properties of primary focal hyperhidrosis patients

    PubMed Central

    2013-01-01

    Background Primary focal hyperhidrosis is a health problem, which has negative effects on the patient's quality of life and significantly affects the patients’ daily activities, social and business life. The aim of this study is to evaluate temperament and character properties of patients diagnosed with primary focal hyperhidrosis. Methods Fifty-six primary focal hyperhidrosis (22.42 ± 7.80) and 49 control subjects (24.48 ± 5.17) participated in the study. Patients who met the diagnostic criteria for PFH were referred to psychiatry clinic where the subjects were evaluated through Structured Clinical Interview for DSM Disorders-I and Temperament and Character Inventory. Results In order to examine the difference between the PFH and control group in terms of temperament and character properties, one-way Multivariate Analysis of Variance (MANOVA) was conducted. In terms of temperament properties, PFH group took significantly higher scores than control group in Fatigability and asthenia dimension. In terms of character properties, PFH group scored significantly lower than control group in Purposefulness , Resourcefulness , Self-Directedness and scored significantly higher than control group in Self-forgetfulness and Self-Transcendence. Conclusion Temperament and character features of PFH patients were different from healthy group and it was considered that these features were affected by many factors including genetic, biological, environmental, socio-cultural elements. During the follow-up of PFH cases, psychiatric evaluation is important and interventions, especially psychotherapeutic interventions can increase the chances of success of the dermatological treatments and can have a positive impact on the quality of life and social cohesion of chronic cases. PMID:23311945

  4. Shuttle infrared telescope facility pointing and control system

    NASA Technical Reports Server (NTRS)

    Lorell, K. R.; Barrows, W. F.; Matsumoto, Y. T.

    1981-01-01

    The Shuttle Infrared Telescope Facility (SIRTF) is being designed as a 0.85 m cryogenically cooled telescope capable of a three order of magnitude improvement over currently available infrared instruments. The SIRTF requires that the image at the focal plane be stabilized to better than 0.25 arcsec with an absolute accuracy of 1.0 arcsec. Current pointing-mount performance simulations indicate that neither of these requirements can be met without additional stabilization. The SIRTF pointing and control system will utilize gyro outputs, star field position measurements from a focal plane fine guidance sensor, and a steerable secondary mirror to provide the necessary stabilization and pointing control. The charge coupled device fine guidance sensor tracks multiple stars simultaneously and, through the use of multistar processing algorithms in a high performance microcomputer, generates three-axis attitude errors and gyro-drift estimates to correct the pointing-mount gyros. A high-bandwidth feedforward loop, driven directly from the pointing-mount gyro package, controls the steering mirror in order to correct disturbances not compensated for by the pointing-mount control system. A prototype design for the SIRTF pointing and control system is described in detail. Performance analyses made using a digital simulation of the pointing and control system as well as experimental data obtained in laboratory and field test measurements are presented.

  5. Focal Choroidal Excavation in Best Vitelliform Macular Dystrophy: Case Report.

    PubMed

    Esfahani, Mohammad Riazi; Esfahani, Hamid Riazi; Mahmoudi, Alireza; Johari, Mohammad Karim; Hemati, Karim

    2015-05-01

    Focal choroidal excavation (FCE) was first reported as a choroidal posteriorly excavated zone without any scleral change. Choroidal excavation also divided into conforming and nonconforming type. Numerous reports demonstrated association between FCE and other disease such as choroidal neovascularization and central serous choroidoretinopathy. Here, we report a rare case of FCE in a patient with Best disease. The patient was diagnosed by spectoral domain optical coherence tomography (SD-OCT). To the best of our knowledge, our patient is the second report of choroidal excavation in Best vitelliform macular dystrophy. PMID:26155505

  6. Focal Choroidal Excavation in Best Vitelliform Macular Dystrophy: Case Report

    PubMed Central

    Esfahani, Mohammad Riazi; Esfahani, Hamid Riazi; Mahmoudi, Alireza; Johari, Mohammad Karim

    2015-01-01

    Focal choroidal excavation (FCE) was first reported as a choroidal posteriorly excavated zone without any scleral change. Choroidal excavation also divided into conforming and nonconforming type. Numerous reports demonstrated association between FCE and other disease such as choroidal neovascularization and central serous choroidoretinopathy. Here, we report a rare case of FCE in a patient with Best disease. The patient was diagnosed by spectoral domain optical coherence tomography (SD-OCT). To the best of our knowledge, our patient is the second report of choroidal excavation in Best vitelliform macular dystrophy. PMID:26155505

  7. Steroid-responsive polyradiculopathy in association with focal segmental glomerulosclerosis

    PubMed Central

    Chapman, Andrew R.; Gamble, Paul; Pollock, Anne Marie; Joss, Nicola

    2013-01-01

    An 80-year-old woman presented with simultaneous increasing muscle weakness and nephrotic syndrome. A renal biopsy confirmed focal segmental glomerulosclerosis (FSGS). Her neurological diagnosis best fitted with a Guillain–Barre-like syndrome. There have been several cases of FSGS in combination with both conventional and atypical Guillain–Barre syndrome (GBS). Our patient was treated with high-dose steroids and resolution of both nephrotic syndrome and neurological symptoms occurred over 6 months. This article reviews all previously published presentations of this nature and discusses putative mechanisms for the development of concurrent FSGS and GBS. PMID:26069832

  8. A working group classification of focal prostate atrophy lesions.

    PubMed

    De Marzo, Angelo M; Platz, Elizabeth A; Epstein, Jonathan I; Ali, Tehmina; Billis, Anthanase; Chan, Teresa Y; Cheng, Liang; Datta, Milton; Egevad, Lars; Ertoy-Baydar, Dilek; Farre, Xavier; Farree, Xavier; Fine, Samson W; Iczkowski, Kenneth A; Ittmann, Michael; Knudsen, Beatrice S; Loda, Massimo; Lopez-Beltran, Antonio; Magi-Galluzzi, Cristina; Mikuz, Gregor; Montironi, Roldolfo; Pikarsky, Eli; Pizov, Galina; Rubin, Mark A; Samaratunga, Hema; Sebo, Thomas; Sesterhenn, Isabel A; Shah, Rajal B; Shah, Rajiv B; Signoretti, Sabina; Simko, Jeffery; Thomas, George; Troncoso, Patricia; Tsuzuki, Toyonori T; van Leenders, Geert J; Yang, Ximing J; Zhou, Ming; Figg, William D; Hoque, Ashraful; Hoque, Ashrafal; Lucia, M S

    2006-10-01

    Focal atrophy is extremely common in prostate specimens. Although there are distinct histologic variants, the terminology is currently nonstandardized and no formal classification has been tested for interobserver reliability. This lack of standardization hampers the ability to study the biologic and clinical significance of these lesions. After informal and formal meetings by a number of the authors, focal atrophy lesions were categorized into 4 distinct subtypes as follows: (i) simple atrophy, (ii) simple atrophy with cyst formation, (iii) postatrophic hyperplasia, and (iv) partial atrophy. In phase 1 of the study, pathologists with varying levels of experience in prostate pathology were invited to view via the Internet a set of "training" images with associated descriptions of lesions considered typical of each subtype. In phase 2 of the study, each participant provided diagnoses on a series of 140 distinct "test" images that were viewed over the Internet. These test images consisted of the 4 subtypes of atrophy and images of normal epithelium, high grade prostatic intraepithelial neoplasia, and carcinoma. The diagnoses for each image from each pathologist were compared with a set of "standard" diagnoses and the kappa statistic was computed. Thirty-four pathologists completed both phases of the study. The interobserver reliability (median kappa) for classification of lesions as normal, cancer, prostatic intraepithelial neoplasia, or focal atrophy was 0.97. The median kappa for the classification of atrophy lesions into the 4 subtypes was 0.80. The median percent agreement with the standard diagnosis for the atrophy subtypes were: simple 60.6%, simple with cyst formation 100%; postatrophic hyperplasia 87.5%; partial atrophy 93.9%. The lower percentage for simple atrophy reflected a propensity to diagnose some of these as simple atrophy with cyst formation. Seven pathologists completed the phase 2 analysis a second time, and their intraobserver reproducibility was

  9. Focal thinning of the cerebral cortex in multiple sclerosis.

    PubMed

    Sailer, Michael; Fischl, Bruce; Salat, David; Tempelmann, Claus; Schönfeld, Mircea Ariel; Busa, Evelina; Bodammer, Nils; Heinze, Hans-Jochen; Dale, Anders

    2003-08-01

    Brain atrophy as determined by quantitative MRI can be used to characterize disease progression in multiple sclerosis. Many studies have addressed white matter (WM) alterations leading to atrophy, while changes of the cerebral cortex have been studied to a lesser extent. In vivo, the cerebral cortex has been difficult to study due to its complex structure and regional variability. Measurement of cerebral cortex thickness at different disease stages may provide new insights into grey matter (GM) pathology. In the present investigation, we evaluated in vivo cortical thickness and its relationship to disability, disease duration, WM T2 hyper-intense and T1 hypo-intense lesion volumes. High-resolution MRI brain scans were obtained in 20 patients with clinically definite multiple sclerosis and 15 age-matched normal subjects. A novel method of automated surface reconstruction yielded measurements of the cortical thickness for each subject's entire brain and computed cross-subject statistics based on the cortical anatomy. Statistical thickness difference maps were generated by performing t-tests between patient and control groups and individual thickness measures were submitted to analyses of variance to investigate the relationship between cortical thickness and clinical variables. The mean overall thickness of the cortical ribbon was reduced in multiple sclerosis patients compared with controls [2.30 mm (SD 0.14) versus 2.48 mm (SD 0.11)], showing a significant main effect of group (controls versus patients). In patients, we found significant main effects for disability, disease duration, T2 and T1 lesion volumes. The visualization of statistical difference maps of the cortical GM thickness on inflated brains across the cortical surface revealed a distinct distribution of significant focal thinning of the cerebral cortex in addition to the diffuse cortical atrophy. Focal cortical thinning in frontal [2.37 mm (SD 0.17) versus 2.73 mm (SD 0.25)] and in temporal [2.65 mm

  10. Assembly and mechanosensory function of focal adhesions: experiments and models.

    PubMed

    Bershadsky, Alexander D; Ballestrem, Christoph; Carramusa, Letizia; Zilberman, Yuliya; Gilquin, Benoit; Khochbin, Saadi; Alexandrova, Antonina Y; Verkhovsky, Alexander B; Shemesh, Tom; Kozlov, Michael M

    2006-04-01

    Initial integrin-mediated cell-matrix adhesions (focal complexes) appear underneath the lamellipodia, in the regions of the "fast" centripetal flow driven by actin polymerization. Once formed, these adhesions convert the flow behind them into a "slow", myosin II-driven mode. Some focal complexes then turn into elongated focal adhesions (FAs) associated with contractile actomyosin bundles (stress fibers). Myosin II inhibition does not suppress formation of focal complexes but blocks their conversion into mature FAs and further FA growth. Application of external pulling force promotes FA growth even under conditions when myosin II activity is blocked. Thus, individual FAs behave as mechanosensors responding to the application of force by directional assembly. We proposed a thermodynamic model for the mechanosensitivity of FAs, taking into account that an elastic molecular aggregate subject to pulling forces tends to grow in the direction of force application by incorporating additional subunits. This simple model can explain a variety of processes typical of FA behavior. Assembly of FAs is triggered by the small G-protein Rho via activation of two major targets, Rho-associated kinase (ROCK) and the formin homology protein, Dia1. ROCK controls creation of myosin II-driven forces, while Dia1 is involved in the response of FAs to these forces. Expression of the active form of Dia1, allows the external force-induced assembly of mature FAs, even in conditions when Rho is inhibited. Conversely, downregulation of Dia1 by siRNA prevents FA maturation even if Rho is activated. Dia1 and other formins cap barbed (fast growing) ends of actin filaments, allowing insertion of the new actin monomers. We suggested a novel mechanism of such "leaky" capping based on an assumption of elasticity of the formin/barbed end complex. Our model predicts that formin-mediated actin polymerization should be greatly enhanced by application of external pulling force. Thus, the formin-actin complex

  11. Focal cooling devices for the surgical treatment of epilepsy.

    PubMed

    Smyth, Matthew D; Rothman, Steven M

    2011-10-01

    Focal cooling may provide a safe, nondestructive alternative to resective and disconnective strategies that have been proposed or used to control refractory epilepsy. Observations of the effects of direct application of iced saline on the cortical surface during cortical mapping surgery and induced seizures have led to interest in developing implantable cooling therapy devices for refractory localizable epilepsies. In this article, the authors provide an overview of the historical background, physiology, and animal and human data leading to the development of implantable cooling devices for the treatment of medically refractory epilepsy. PMID:21939851

  12. Current Status of Focal Cryoablation for Small Renal Masses.

    PubMed

    Rodriguez Faba, Oscar; Akdogan, Bullent; Marszalek, Martin; Langenhuijsen, J F; Brookman-May, Sabine; Stewart, Grant D; Capitanio, Umberto; Sanguedolce, Francesco

    2016-04-01

    Focal cryoablation is an established minimally invasive technique for the treatment of small renal masses. Because of the lack of robust evidence, it is indicated in selected patients who have relative contraindications to extirpative approaches. With appropriate selection of patients, cryoablation is safe and effective. Main advantages are low risk for complication, minimal invasiveness, and good functional outcomes; oncological outcomes require further studies. The role of the percutaneous approach has been expanding because of its ability to reduce pain and hospitalization, the possibility of performing the procedure under sedation, and the fact that it is potentially more cost effective. PMID:26743392

  13. Focal-plane detector system for the KATRIN experiment

    NASA Astrophysics Data System (ADS)

    Amsbaugh, J. F.; Barrett, J.; Beglarian, A.; Bergmann, T.; Bichsel, H.; Bodine, L. I.; Bonn, J.; Boyd, N. M.; Burritt, T. H.; Chaoui, Z.; Chilingaryan, S.; Corona, T. J.; Doe, P. J.; Dunmore, J. A.; Enomoto, S.; Formaggio, J. A.; Fränkle, F. M.; Furse, D.; Gemmeke, H.; Glück, F.; Harms, F.; Harper, G. C.; Hartmann, J.; Howe, M. A.; Kaboth, A.; Kelsey, J.; Knauer, M.; Kopmann, A.; Leber, M. L.; Martin, E. L.; Middleman, K. J.; Myers, A. W.; Oblath, N. S.; Parno, D. S.; Peterson, D. A.; Petzold, L.; Phillips, D. G.; Renschler, P.; Robertson, R. G. H.; Schwarz, J.; Steidl, M.; Tcherniakhovski, D.; Thümmler, T.; Van Wechel, T. D.; VanDevender, B. A.; Vöcking, S.; Wall, B. L.; Wierman, K. L.; Wilkerson, J. F.; Wüstling, S.

    2015-04-01

    The focal-plane detector system for the KArlsruhe TRItium Neutrino (KATRIN) experiment consists of a multi-pixel silicon p-i-n-diode array, custom readout electronics, two superconducting solenoid magnets, an ultra high-vacuum system, a high-vacuum system, calibration and monitoring devices, a scintillating veto, and a custom data-acquisition system. It is designed to detect the low-energy electrons selected by the KATRIN main spectrometer. We describe the system and summarize its performance after its final installation.

  14. Focal Length Controllable Ultrasonic Array Transducer with Adjustable Curvature

    NASA Astrophysics Data System (ADS)

    Kim, Jungsoon; Kim, Moojoon; Ha, Kanglyel

    2012-07-01

    In the underwater imaging field, the control of the focal length of a transducer is very useful. As one of the control methods, we suggested an ultrasonic array transducer with adjustable curvature by using air pressure. The curvature of the transducer was investigated according to the air pressure level in the back space of the transducer. Concave-, planar-, and convex-type transducers were obtained with different air pressure levels. The acoustic fields of the transducer were measured for different shapes of the radiation surface.

  15. Focal elastic obstruction of the inferior vena cava.

    PubMed

    Helmy, T; Ware, D L; Patterson, C; Stouffer, G A

    2000-12-01

    Obstruction of the supra-hepatic inferior vena cava (IVC) is a common cause of hepatic venous hypertension and the most common cause of Budd-Chiari Syndrome. Because most cases of IVC obstruction go undiagnosed until Budd-Chiari Syndrome develops, the natural history of IVC obstruction is not well defined. We report a case of a focal, elastic, non-membranous obstruction of the IVC causing hepatic venous hypertension and elevated serum transaminases in a 36-year-old man. The obstruction was successfully treated with placement of a self-expanding metallic stent with normalization of hepatic transaminases. PMID:11108690

  16. Focal plane detectors possible detector technologies for OWL/AIRWATCH

    SciTech Connect

    Flyckt, Esso

    1998-06-15

    New satellite-born projects OWL and AIRWATCH will need single-photon focal-plane detectors of a million pixels in a design which is optimized to the focusing optics and electronics at acceptable cost. We discuss different phototube possibilities and their pros and cons with crude cost estimates. We conclude that a multichannel-photomultiplier solution is safe. A better compromise may be to adapt a 6 or 9 inch X-ray image intensifier tube or develop a 12 inch image intensifier for detecting individual photons, and adapt the optics to have many mirror modules. The possibility of developing super-large-area phototubes is also discussed.

  17. Alignment and calibration of a focal neurotransmitter uncaging system.

    PubMed

    Sarkisov, Dmitry V; Wang, Samuel S-H

    2006-01-01

    Photolysis of caged compounds is a powerful tool for studying subcellular physiological functions. Here we describe protocols for the alignment and calibration of a focal uncaging system. We also report procedures for convenient quantitative calibration of uncaging. Using these methods, we can achieve submicron lateral resolution of photolysis and probe biological function in spines, the smallest signaling compartments of neurons. Initially, the entire alignment procedure takes 4-6 h to perform; periodic fine-tuning of the system takes 1-2 h. PMID:17406314

  18. Unilateral brain oedema related to focal status epilepticus

    PubMed Central

    Ali, Noura Abdulwahid; Palat Chirakkara, Sudhir Kumar; Reddy, Jagan Jinna; Sinha, Shobhit

    2013-01-01

    We present a female patient in her late 30s, with baseline vegetative state following prior traumatic brain injury, who presented with prolonged right hemispheric status epilepticus. The neuroimaging revealed a striking right-sided pancortical oedema with left (crossed) cerebellar diaschisis and dilation of right hemispheric arteries. EEG was concordant and showed nearly continuous right hemispheric seizure discharges with suppressed background. Infective and vascular aetiologies were ruled out. The patient showed clinical and electrographic improvement following treatment with antiepileptic drugs. Unilateral cerebral oedema is a rare presentation of focal status epilepticus, and should be considered as a differential diagnosis in the appropriate clinical scenario. PMID:24334523

  19. Focal plane array with modular pixel array components for scalability

    SciTech Connect

    Kay, Randolph R; Campbell, David V; Shinde, Subhash L; Rienstra, Jeffrey L; Serkland, Darwin K; Holmes, Michael L

    2014-12-09

    A modular, scalable focal plane array is provided as an array of integrated circuit dice, wherein each die includes a given amount of modular pixel array circuitry. The array of dice effectively multiplies the amount of modular pixel array circuitry to produce a larger pixel array without increasing die size. Desired pixel pitch across the enlarged pixel array is preserved by forming die stacks with each pixel array circuitry die stacked on a separate die that contains the corresponding signal processing circuitry. Techniques for die stack interconnections and die stack placement are implemented to ensure that the desired pixel pitch is preserved across the enlarged pixel array.

  20. [The focal control of malaria. Focal treatment using chemoprophylaxis and home insecticide spraying for the control of malaria in southern Mexico].

    PubMed

    Rodríguez López, M H; Loyola Elizondo, E G; Betanzos Reyes, A F; Villarreal Treviño, C; Bown, D N

    1994-01-01

    The efficacy of a focal control strategy for malaria was evaluated against a conventional scheme carried out in two groups of villages in the Soconusco, southern Chiapas, Mexico. Focal control consisted on the prophylactic administration of antimalarial drugs to people who had experienced malaria episodes two years previous to the study. Homes of these malaria patients were also sprayed indoors with DDT. The traditional strategy consisted on the treatment of all patients with antimalarial drugs as well as indoor spraying with DDT of all houses in the villages. Results from the focal control demonstrated similar efficacy as compared to conventional. However, in terms of cost, focal control was four fold more economical. Focal control had an additional advantage of incorporating community participation within the control operations. PMID:7607360

  1. Polychlorinated biphenyl quinone induces endothelial barrier dysregulation by setting the cross talk between VE-cadherin, focal adhesion, and MAPK signaling.

    PubMed

    Zhang, Pu; Feng, Shan; Bai, Huiyuan; Zeng, Panying; Chen, Feng; Wu, Chengxiang; Peng, Yi; Zhang, Qin; Zhang, Qiuyao; Ye, Qichao; Xue, Qiang; Xu, Xiaoyu; Song, Erqun; Song, Yang

    2015-05-15

    Environmental hazardous material polychlorinated biphenyl (PCB) exposure is associated with vascular endothelial dysfunction, which may increase the risk of cardiovascular diseases and cancer metastasis. Our previous studies illustrated the cytotoxic, antiproliferative, and genotoxic effects of a synthetic, quinone-type, highly reactive metabolite of PCB, 2,3,5-trichloro-6-phenyl-[1,4]benzoquinone (PCB29-pQ). Here, we used it as the model compound to investigate its effects on vascular endothelial integrity and permeability. We demonstrated that noncytotoxic doses of PCB29-pQ induced vascular endothelial (VE)-cadherin junction disassembly by increasing the phosphorylation of VE-cadherin at Y658. We also found that focal adhesion assembly was required for PCB29-pQ-induced junction breakdown. Focal adhesion site-associated actin stress fibers may serve as holding points for cytoskeletal tension to regulate the cellular contractility. PCB29-pQ exposure promoted the association of actin stress fibers with paxillin-containing focal adhesion sites and enlarged the size/number of focal adhesions. In addition, PCB29-pQ treatment induced phosphorylation of paxillin at Y118. By using pharmacological inhibition, we further demonstrated that p38 activation was necessary for paxillin phosphorylation, whereas extracellular signal-regulated kinases-1/2 activation regulated VE-cadherin phosphorylation. In conclusion, these results indicated that PCB29-pQ stimulates endothelial hyperpermeability by mediating VE-cadherin disassembly, junction breakdown, and focal adhesion formation. Intervention strategies targeting focal adhesion and MAPK signaling could be used as therapeutic approaches for preventing adverse cardiovascular health effects induced by environmental toxicants such as PCBs. PMID:25770237

  2. Super-oscillatory focusing of circularly polarized light by ultra-long focal length planar lens based on binary amplitude-phase modulation

    PubMed Central

    Chen, Gang; Li, Yuyan; Yu, Anping; Wen, Zhongquan; Dai, Luru; Chen, Li; Zhang, Zhihai; Jiang, Senlin; Zhang, Kun; Wang, Xianyou; Lin, Feng

    2016-01-01

    In traditional optics, the focal spot size of a conventional lens is restricted to the diffraction limit 0.5λ/NA, where λ is the wavelength in vacuum and NA is the numerical aperture of the lens. Recently, various sub-diffraction focusing optical devices have been demonstrated, but they usually have short focal length and high numerical aperture. Moreover, they always suffer the problem of huge sidelobes near the focal spot and small field of view, especially when the focal spot size is less than the super-oscillation criteria 0.38λ/NA. To address the problem, here, we reported a far-field sub-diffraction point-focusing lens based on binary phase and amplitude modulation with ultra-long focal length 252.8 μm (399.5λ) and small numerical aperture 0.78, and experimentally demonstrated a super-oscillatory focusing of circularly polarized light with spot size 287 nm (0.454λ), smaller than the diffraction limit 0.64λ and the super-oscillation criterion 0.487λ. What’s more, on the focal plane, in the measured area within the radius of 142λ, the largest sidelobe intensity is less than 26% of the central lobe intensity. Such ultra-long distance super-oscillatory focusing with small sidelobes and large field of view has great potential applications in far-field super-resolution microscopy, ultra-high-density optical storage and nano-fabrication. PMID:27353239

  3. Super-oscillatory focusing of circularly polarized light by ultra-long focal length planar lens based on binary amplitude-phase modulation.

    PubMed

    Chen, Gang; Li, Yuyan; Yu, Anping; Wen, Zhongquan; Dai, Luru; Chen, Li; Zhang, Zhihai; Jiang, Senlin; Zhang, Kun; Wang, Xianyou; Lin, Feng

    2016-01-01

    In traditional optics, the focal spot size of a conventional lens is restricted to the diffraction limit 0.5λ/NA, where λ is the wavelength in vacuum and NA is the numerical aperture of the lens. Recently, various sub-diffraction focusing optical devices have been demonstrated, but they usually have short focal length and high numerical aperture. Moreover, they always suffer the problem of huge sidelobes near the focal spot and small field of view, especially when the focal spot size is less than the super-oscillation criteria 0.38λ/NA. To address the problem, here, we reported a far-field sub-diffraction point-focusing lens based on binary phase and amplitude modulation with ultra-long focal length 252.8 μm (399.5λ) and small numerical aperture 0.78, and experimentally demonstrated a super-oscillatory focusing of circularly polarized light with spot size 287 nm (0.454λ), smaller than the diffraction limit 0.64λ and the super-oscillation criterion 0.487λ. What's more, on the focal plane, in the measured area within the radius of 142λ, the largest sidelobe intensity is less than 26% of the central lobe intensity. Such ultra-long distance super-oscillatory focusing with small sidelobes and large field of view has great potential applications in far-field super-resolution microscopy, ultra-high-density optical storage and nano-fabrication. PMID:27353239

  4. Super-oscillatory focusing of circularly polarized light by ultra-long focal length planar lens based on binary amplitude-phase modulation

    NASA Astrophysics Data System (ADS)

    Chen, Gang; Li, Yuyan; Yu, Anping; Wen, Zhongquan; Dai, Luru; Chen, Li; Zhang, Zhihai; Jiang, Senlin; Zhang, Kun; Wang, Xianyou; Lin, Feng

    2016-06-01

    In traditional optics, the focal spot size of a conventional lens is restricted to the diffraction limit 0.5λ/NA, where λ is the wavelength in vacuum and NA is the numerical aperture of the lens. Recently, various sub-diffraction focusing optical devices have been demonstrated, but they usually have short focal length and high numerical aperture. Moreover, they always suffer the problem of huge sidelobes near the focal spot and small field of view, especially when the focal spot size is less than the super-oscillation criteria 0.38λ/NA. To address the problem, here, we reported a far-field sub-diffraction point-focusing lens based on binary phase and amplitude modulation with ultra-long focal length 252.8 μm (399.5λ) and small numerical aperture 0.78, and experimentally demonstrated a super-oscillatory focusing of circularly polarized light with spot size 287 nm (0.454λ), smaller than the diffraction limit 0.64λ and the super-oscillation criterion 0.487λ. What’s more, on the focal plane, in the measured area within the radius of 142λ, the largest sidelobe intensity is less than 26% of the central lobe intensity. Such ultra-long distance super-oscillatory focusing with small sidelobes and large field of view has great potential applications in far-field super-resolution microscopy, ultra-high-density optical storage and nano-fabrication.

  5. Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism.

    PubMed

    Riveline, D; Zamir, E; Balaban, N Q; Schwarz, U S; Ishizaki, T; Narumiya, S; Kam, Z; Geiger, B; Bershadsky, A D

    2001-06-11

    The transition of cell-matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, activation of myosin II-driven contractility by a Rho target known as Rho-associated kinase (ROCK) was shown to be essential for focal contact formation. To dissect the mechanism of Rho-dependent induction of focal contacts and to elucidate the role of cell contractility, we applied mechanical force to vinculin-containing dot-like adhesions at the cell edge using a micropipette. Local centripetal pulling led to local assembly and elongation of these structures and to their development into streak-like focal contacts, as revealed by the dynamics of green fluorescent protein-tagged vinculin or paxillin and interference reflection microscopy. Inhibition of Rho activity by C3 transferase suppressed this force-induced focal contact formation. However, constitutively active mutants of another Rho target, the formin homology protein mDia1 (Watanabe, N., T. Kato, A. Fujita, T. Ishizaki, and S. Narumiya. 1999. Nat. Cell Biol. 1:136-143), were sufficient to restore force-induced focal contact formation in C3 transferase-treated cells. Force-induced formation of the focal contacts still occurred in cells subjected to myosin II and ROCK inhibition. Thus, as long as mDia1 is active, external tension force bypasses the requirement for ROCK-mediated myosin II contractility in the induction of focal contacts. Our experiments show that integrin-containing focal complexes behave as individual mechanosensors exhibiting directional assembly in response to local force. PMID:11402062

  6. Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling

    PubMed Central

    Suzuki, Nobuharu; Numakawa, Tadahiro; Chou, Joshua; de Vega, Susana; Mizuniwa, Chihiro; Sekimoto, Kaori; Adachi, Naoki; Kunugi, Hiroshi; Arikawa-Hirasawa, Eri; Yamada, Yoshihiko; Akazawa, Chihiro

    2014-01-01

    Teneurin-4 (Ten-4), a transmembrane protein, is highly expressed in the central nervous system; however, its cellular and molecular function in neuronal differentiation remains unknown. In this study, we aimed to elucidate the function of Ten-4 in neurite outgrowth. Ten-4 expression was induced during neurite outgrowth of the neuroblastoma cell line Neuro-2a. Ten-4 protein was localized at the neurite growth cones. Knockdown of Ten-4 expression in Neuro-2a cells decreased the formation of the filopodia-like protrusions and the length of individual neurites. Conversely, overexpression of Ten-4 promoted filopodia-like protrusion formation. In addition, knockdown and overexpression of Ten-4 reduced and elevated the activation of focal adhesion kinase (FAK) and Rho-family small GTPases, Cdc42 and Rac1, key molecules for the membranous protrusion formation downstream of FAK, respectively. Inhibition of the activation of FAK and neural Wiskott-Aldrich syndrome protein (N-WASP), which is a downstream regulator of FAK and Cdc42, blocked protrusion formation by Ten-4 overexpression. Further, Ten-4 colocalized with phosphorylated FAK in the filopodia-like protrusion regions. Together, our findings show that Ten-4 is a novel positive regulator of cellular protrusion formation and neurite outgrowth through the FAK signaling pathway.—Suzuki, N., Numakawa, T., Chou, J., de Vega, S., Mizuniwa, C., Sekimoto, K., Adachi, N., Kunugi, H., Arikawa-Hirasawa, E., Yamada, Y., Akazawa, C. Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling. PMID:24344332

  7. Brain SPECT with short focal-length cone-beam collimation

    SciTech Connect

    Park, Mi-Ae; Moore, Stephen C.; Kijewski, Marie Foley

    2005-07-15

    Single-photon emission-computed tomography (SPECT) imaging of deep brain structures is compromised by loss of photons due to attenuation. We have previously shown that a centrally peaked collimator sensitivity function can compensate for this phenomenon, increasing sensitivity over most of the brain. For dual-head instruments, parallel-hole collimators cannot provide variable sensitivity without simultaneously degrading spatial resolution near the center of the brain; this suggests the use of converging collimators. We have designed collimator pairs for dual-head SPECT systems to increase sensitivity, particularly in the center of the brain, and compared the new collimation approach to existing approaches on the basis of performance in estimating activity concentration of small structures at various locations in the brain. The collimator pairs we evaluated included a cone-beam collimator, for increased sensitivity, and a fan-beam collimator, for data sufficiency. We calculated projections of an ellipsoidal uniform background, with 0.9-cm-radius spherical lesions at several locations in the background. From these, we determined ideal signal-to-noise ratios (SNR{sub CRB}) for estimation of activity concentration within the spheres, based on the Cramer-Rao lower bound on variance. We also reconstructed, by an ordered-subset expectation-maximization (OS-EM) procedure, images of this phantom, as well as of the Zubal brain phantom, to allow visual assessment and to ensure that they were free of artifacts. The best of the collimator pairs evaluated comprised a cone-beam collimator with 20 cm focal length, for which the focal point is inside the brain, and a fan-beam collimator with 40 cm focal length. This pair yielded increased SNR{sub CRB}, compared to the parallel-parallel pair, throughout the imaging volume. The factor by which SNR{sub CRB} increased ranged from 1.1 at the most axially extreme location to 3.5 at the center. The gains in SNR{sub CRB} were relatively

  8. Antenna coupled detectors for 2D staring focal plane arrays

    NASA Astrophysics Data System (ADS)

    Gritz, Michael A.; Kolasa, Borys; Lail, Brian; Burkholder, Robert; Chen, Leonard

    2013-06-01

    Millimeter-wave (mmW)/sub-mmW/THz region of the electro-magnetic spectrum enables imaging thru clothing and other obscurants such as fog, clouds, smoke, sand, and dust. Therefore considerable interest exists in developing low cost millimeter-wave imaging (MMWI) systems. Previous MMWI systems have evolved from crude mechanically scanned, single element receiver systems into very complex multiple receiver camera systems. Initial systems required many expensive mmW integrated-circuit low-noise amplifiers. In order to reduce the cost and complexity of the existing systems, attempts have been made to develop new mmW imaging sensors employing direct detection arrays. In this paper, we report on Raytheon's recent development of a unique focal plane array technology, which operates broadly from the mmW through the sub-mmW/THz region. Raytheon's innovative nano-antenna based detector enables low cost production of 2D staring mmW focal plane arrays (mmW FPA), which not only have equivalent sensitivity and performance to existing MMWI systems, but require no mechanical scanning.

  9. Focal liver lesions: Practical magnetic resonance imaging approach

    PubMed Central

    Matos, António P; Velloni, Fernanda; Ramalho, Miguel; AlObaidy, Mamdoh; Rajapaksha, Aruna; Semelka, Richard C

    2015-01-01

    With the widespread of cross-sectional imaging, a growth of incidentally detected focal liver lesions (FLL) has been observed. A reliable detection and characterization of FLL is critical for optimal patient management. Maximizing accuracy of imaging in the context of FLL is paramount in avoiding unnecessary biopsies, which may result in post-procedural complications. A tremendous development of new imaging techniques has taken place during these last years. Nowadays, Magnetic resonance imaging (MRI) plays a key role in management of liver lesions, using a radiation-free technique and a safe contrast agent profile. MRI plays a key role in the non-invasive correct characterization of FLL. MRI is capable of providing comprehensive and highly accurate diagnostic information, with the additional advantage of lack of harmful ionizing radiation. These properties make MRI the mainstay for the noninvasive evaluation of focal liver lesions. In this paper we review the state-of-the-art MRI liver protocol, briefly discussing different sequence types, the unique characteristics of imaging non-cooperative patients and discuss the role of hepatocyte-specific contrast agents. A review of the imaging features of the most common benign and malignant FLL is presented, supplemented by a schematic representation of a simplistic practical approach on MRI. PMID:26261689

  10. Focal liver lesions: Practical magnetic resonance imaging approach.

    PubMed

    Matos, António P; Velloni, Fernanda; Ramalho, Miguel; AlObaidy, Mamdoh; Rajapaksha, Aruna; Semelka, Richard C

    2015-08-01

    With the widespread of cross-sectional imaging, a growth of incidentally detected focal liver lesions (FLL) has been observed. A reliable detection and characterization of FLL is critical for optimal patient management. Maximizing accuracy of imaging in the context of FLL is paramount in avoiding unnecessary biopsies, which may result in post-procedural complications. A tremendous development of new imaging techniques has taken place during these last years. Nowadays, Magnetic resonance imaging (MRI) plays a key role in management of liver lesions, using a radiation-free technique and a safe contrast agent profile. MRI plays a key role in the non-invasive correct characterization of FLL. MRI is capable of providing comprehensive and highly accurate diagnostic information, with the additional advantage of lack of harmful ionizing radiation. These properties make MRI the mainstay for the noninvasive evaluation of focal liver lesions. In this paper we review the state-of-the-art MRI liver protocol, briefly discussing different sequence types, the unique characteristics of imaging non-cooperative patients and discuss the role of hepatocyte-specific contrast agents. A review of the imaging features of the most common benign and malignant FLL is presented, supplemented by a schematic representation of a simplistic practical approach on MRI. PMID:26261689

  11. Focal choroidal excavation in patients with central serous chorioretinopathy

    PubMed Central

    Luk, F O J; Fok, A C T; Lee, A; Liu, A T W; Lai, T Y Y

    2015-01-01

    Purpose To evaluate the prevalence and clinical features of focal choroidal excavation (FCE) in patients presenting with central serous chorioretinopathy (CSC). Methods This is a retrospective consecutive case series of consecutive patients with CSC who were referred for spectral domain optical coherence tomography (SD-OCT) between January 2010 and December 2011. Medical records were reviewed and clinical features including presence of FCE in SD-OCT, fluorescence angiography (FA), and indocyanine green angiography (ICGA) were studied. Results Among the 116 CSC patients assessed, FCE was found in 11 eyes of 7 (6.0%) patients. FCE was associated with subretinal fluid in six eyes of six patients and serous pigment epithelial detachment in three eyes of two patients. The mean central subfield retinal thickness of CSC eyes with FCE was 283.7 μm, compared with 377.5 μm for CSC eyes without FCE (Mann–Whitney U-test, P=0.020). Five FCE eyes of five patients had focal leakage on FA. Choroidal hyperpermeability on ICGA was found in seven CSC eyes with FCE, with four eyes showing hypofluorescent spot corresponding to the FCE. After a mean follow-up of 16 months, visual acuity of all 11 eyes with FCE remained stable or improved at the last follow-up. Conclusion FCE is not an uncommon feature in patients with CSC and might be associated with choroidal hemodynamic disturbances. PMID:25853402

  12. Intracranial Cortical Calcifications in a Focal Epilepsy Patient with Pseudohypoparathyroidism

    PubMed Central

    Kim, Ye Sel; Park, Jihyung; Park, Yoonkyung; Hwang, KyoungJin; Koo, Dae Lim; Kim, Daeyoung; Seo, Dae-Won

    2016-01-01

    Patients with chronic parathyroid dysfunction often have intracranial calcification in deep gray matter (GM) and subcortical white matter (WM) of their brain. Some of them are also epilepsy patients. Although cortical etiologies are main cause of epileptic seizure, cortical calcification has not been reported in these patients. We report a newly diagnosed focal epilepsy patient whose brain magnetic resonance imaging revealed intracranial calcifications in cortical as well as subcortical areas. Blood lab revealed that he had hypocalcemia due to pseudohypoparathyroidism. Video EEG monitoring revealed the ictal EEG mainly consist of polymorphic delta to theta waves with maximum at right temporal area followed by background attenuation and muscle artifacts. The interictal EEG showed multiple focal spike-wave discharges. After given oral calcium and calcitriol supplement, his calcium and phosphorous level normalized and he remains seizure free. This is the first case to show cortical calcification in a patient with pseudohypoparathyroidism. Cortical calcification could be an important measure of seizure burden in these patients and thus sophisticated imaging protocols should be used to visualize the extent of calcium deposits. PMID:27390678

  13. Fluorescent real-time monitoring of HIFU cardiac focal ablation

    NASA Astrophysics Data System (ADS)

    Qu, Fujian; Nikolski, Vladimir; Efimov, Igor; Deng, Cheri

    2001-05-01

    To study HIFU cardiac ablation, florescent imaging was used to monitor in real time the electrophysiology changes of cardiac tissues during focal HIFU ablation. We applied HIFU ablation of AV nodal and ventricular preparations of Langendorff-perfused rabbit heart while monitoring electrical activity in real-time. HIFU energy was applied to ablate the AV node and ventricular tissue of Langendorff-perfused rabbit hearts while monitoring electrical activity in real-time with fluorescent voltage-sensitive dye imaging and surface electrodes. HIFU was generated using a spherical piezoelectric ceramics transducer (diameter 42 mm, F-number 1.2) at 4.23 MHz. When HIFU was applied to ventricular epicardium fluorescent imaging it revealed gradual reduction of the plateau phase and amplitude of the action potential. Subsequently conduction block and cell death were observed at the site of ablation. In our study HIFU produced focal lesions of 0.2-0.8 mm for 10-60-s applications. When HIFU was applied to the AV node, fluorescent imaging and electrograms revealed the development of the AV block.

  14. Pathology of prostate cancer and focal therapy ('male lumpectomy').

    PubMed

    Mazzucchelli, Roberta; Scarpelli, Marina; Cheng, Liang; Lopez-Beltran, Antonio; Galosi, Andrea B; Kirkali, Ziya; Montironi, Rodolfo

    2009-12-01

    Focal therapy of the prostate is defined as prostate gland ablation aiming at eradication of unifocal low-risk prostate cancer, and preserving uninvolved (peri-) prostatic tissue and therefore quality of life. The major arguments against focal therapy can be classified under the headings of understaging and multifocality. The argument of understaging highlights the importance of the occasional, but troublesome, finding of a large, extraprostatic or high-grade tumor (Gleason score > or = 7) in about a quarter of radical prostatectomy specimens removed from men initially classified as having a low-risk tumor. Indeed, 85% of all prostate cancer cases are multifocal. These concerns can be offset by additional testing: another biopsy, especially a transperineal mapping biopsy, and magnetic resonance imaging (MRI) of the prostate. The technology needed to ablate small regions or sectors of the prostate harboring a known cancer is rapidly becoming available. Cryotherapy is already being used and the preliminary data are encouraging, Ultrasound-guided high-intensity focused ultrasound (HIFU), photodynamic therapy using newly developed light-sensitizing agents, and MRI-guided HIFU are all promising new tools. PMID:20044631

  15. Basic mechanisms leading to focal emphysema in coal workers' pneumoconiosis

    SciTech Connect

    Rom, W.N. )

    1990-10-01

    Coal miners develop focal emphysema characterized by dilatation of second- and third-order respiratory bronchioles with coal mine dust-laden macrophages infiltrating the wall. A reticulin network with small amounts of collagen and atrophy of smooth muscle occurs. To evaluate the mechanisms of lung injury associated with this lesion, 17 long-term non- or ex-smoking West Virginia underground coal miners underwent bronchoalveolar lavage (BAL) and were compared to healthy nonsmoker and smoker controls. The coal miners had evidence of an alveolar macrophage-neutrophil alveolitis with a significant increase in neutrophils/microliter of epithelial lining fluid and an increased gallium lung scan index (206 +/- 26 units). Alveolar macrophages lavaged from coal miners spontaneously released exaggerated amounts of superoxide anion and hydrogen peroxide in vitro compared to nonsmoking controls. Coal workers had significantly elevated levels of neutrophil elastase in BAL fluid complexed with alpha 1-antitrypsin (P less than 0.01) and normal levels of alpha 1-antitrypsin. An accumulation of activated, dust-laden inflammatory cells with increased release of oxidants and elastase may contribute to the development of focal emphysema identified at postmortem in miners with coal workers' pneumoconiosis.

  16. Performance characterization of a PIAA complex focal plane mask

    NASA Astrophysics Data System (ADS)

    Newman, Kevin; Belikov, Ruslan; Guyon, Olivier; Pluzhnik, Eugene

    2015-01-01

    The Phase Induced Amplitude Apodization Complex Mask Coronagraph (PIAACMC) is an architecture for directly observing extrasolar planets, and can achieve performance near the theoretical limits for any direct-detection instrument. PIAACMC can be designed for centrally-obscured and segmented apertures, which is particularly useful for next-generation telescopes. The PIAACMC architecture includes aspheric PIAA optics, and a complex phase-shifting focal plane mask that provides a pi phase shift to a portion of the on-axis starlight. The phase-shifted starlight is forced to interfere destructively with the un-shifted starlight, causing the starlight to be eliminated, and allowing a region for high-contrast imaging near the star.The main challenge in designing the complex focal plane mask is to achieve deep contrast over a wide spectral band. Another challenge for the mask design is to avoid sharp features, which can be difficult to manufacture. We present a solution to the design challenge by dividing the mask into sections and optimizing the phase shift produced by each section. We also demonstrate a method to design the mask with a smooth profile. One remaining challenge is to measure the performance of the mask. We present a method to compute the phase profile of the mask based on measurements of the diffraction pattern. The computed phase profile is used to simulate the expected coronagraph performance.

  17. Focal accumulation of defences at sites of fungal pathogen attack

    PubMed Central

    Underwood, William; Somerville, Shauna C.

    2008-01-01

    Plants resist attack by haustorium-forming biotrophic and hemi-biotrophic fungi through fortification of the cell wall to prevent penetration through the wall and the subsequent establishment of haustorial feeding structures by the fungus. While the existence of cell wall-based defences has been known for many years, only recently have the molecular components contributing to such defences been identified. Forward genetic screens identified Arabidopsis mutants impaired in penetration resistance to powdery mildew fungi that were normally halted at the cell wall. Several loci contributing to penetration resistance have been identified and a common feature is the striking focal accumulation of proteins associated with penetration resistance at sites of interaction with fungal appressoria and penetration pegs. The focal accumulation of defence-related proteins and the deposition of cell wall reinforcements at sites of attempted fungal penetration represent an example of cell polarization and raise many questions of relevance, not only to plant pathology but also to general cell biology. PMID:18703493

  18. Implications of the focal beam profile in serial femtosecond crystallography

    SciTech Connect

    Galli, Lorenzo; Chapman, Henry N.; Metcalf, Peter

    2015-05-12

    The photon density profile of an X-ray free-electron laser (XFEL) beam at the focal position is a critical parameter for serial femtosecond crystallography (SFX), but is difficult to measure because of the destructive power of the beam. A novel high intensity radiation induced phasing method (HIRIP) has been proposed as a general experimental approach for protein structure determination, but has proved to be sensitive to variations of the X-ray intensity, with uniform incident fluence desired for best performance. Here we show that experimental SFX data collected at the nano-focus chamber of the Coherent X-ray Imaging end-station at the Linac Coherent Light Source using crystals with a limited size distribution suggests an average profile of the X-ray beam that has a large variation of intensity. We propose a new method to improve the quality of high fluence data for HI-RIP, by identifying and removing diffraction patterns from crystals exposed to the low intensity region of the beam. The method requires crystals of average size comparable to the width of the focal spot.

  19. Brain polyphosphoinositide metabolism during focal ischemia in rat cortex

    SciTech Connect

    Lin, T.N.; Liu, T.H.; Xu, J.; Hsu, C.Y.; Sun, G.Y. )

    1991-04-01

    Using a rat model of stroke, we examined the effects of focal cerebral ischemia on the metabolism of polyphosphoinositides by injecting {sup 32}Pi into both the left and right cortices. After equilibration of the label for 2-3 hours, ischemia induced a significant decrease (p less than 0.001) in the concentrations of labeled phosphatidyl 4,5-bisphosphates (66-78%) and phosphatidylinositol 4-phosphate (64-67%) in the right middle cerebral artery cortex of four rats. The phospholipid labeling pattern in the left middle cerebral artery cortex, which sustained only mild ischemia and no permanent tissue damage, was not different from that of two sham-operated controls. However, when {sup 32}Pi was injected 1 hour after the ischemic insult, there was a significant decrease (p less than 0.01) in the incorporation of label into the phospholipids in both cortices of four ischemic rats compared with four sham-operated controls. Furthermore, differences in the phospholipid labeling pattern were observed in the left cortex compared with the sham-operated controls. The change in labeling pattern was attributed to the partial reduction in blood flow following ligation of the common carotid arteries. We provide a sensitive procedure for probing the effects of focal cerebral ischemia on the polyphosphoinositide signaling pathway in the brain, which may play an important role in the pathogenesis of tissue injury.

  20. Integrin activation and focal complex formation in cardiac hypertrophy

    NASA Technical Reports Server (NTRS)

    Laser, M.; Willey, C. D.; Jiang, W.; Cooper, G. 4th; Menick, D. R.; Zile, M. R.; Kuppuswamy, D.

    2000-01-01

    Cardiac hypertrophy is characterized by both remodeling of the extracellular matrix (ECM) and hypertrophic growth of the cardiocytes. Here we show increased expression and cytoskeletal association of the ECM proteins fibronectin and vitronectin in pressure-overloaded feline myocardium. These changes are accompanied by cytoskeletal binding and phosphorylation of focal adhesion kinase (FAK) at Tyr-397 and Tyr-925, c-Src at Tyr-416, recruitment of the adapter proteins p130(Cas), Shc, and Nck, and activation of the extracellular-regulated kinases ERK1/2. A synthetic peptide containing the Arg-Gly-Asp (RGD) motif of fibronectin and vitronectin was used to stimulate adult feline cardiomyocytes cultured on laminin or within a type-I collagen matrix. Whereas cardiocytes under both conditions showed RGD-stimulated ERK1/2 activation, only collagen-embedded cells exhibited cytoskeletal assembly of FAK, c-Src, Nck, and Shc. In RGD-stimulated collagen-embedded cells, FAK was phosphorylated only at Tyr-397 and c-Src association occurred without Tyr-416 phosphorylation and p130(Cas) association. Therefore, c-Src activation is not required for its cytoskeletal binding but may be important for additional phosphorylation of FAK. Overall, our study suggests that multiple signaling pathways originate in pressure-overloaded heart following integrin engagement with ECM proteins, including focal complex formation and ERK1/2 activation, and many of these pathways can be activated in cardiomyocytes via RGD-stimulated integrin activation.

  1. A prospective study of collapsing focal segmental glomerulosclerosis.

    PubMed

    Raja, Ramachandran; Nada, Ritambhra; Yadav, Ashok K; Kumar, Ashwani; Goyal, Ajay; Kumar, Vivek; Rathi, Manish; Kohli, H S; Gupta, K L; Sakhuja, Vinay; Jha, Vivekanand

    2016-07-01

    Collapsing focal segmental glomerulosclerosis (cFSGS) is characterized by rapid progression to end-stage renal disease (ESRD). We evaluated the clinicopathological spectrum of cFSGS and compared its clinical behavior to steroid and tacrolimus (TAC)-resistant noncollapsing focal segmental glomerulosclerosis (FSGS). All patients (>14 years) diagnosed with cFSGS were enrolled in the study. Staining for differentiated podocyte markers such as WT 1, PAX and KI67 were performed in all patients. The outcome and histological features of cFSGS was compared with a prospectively followed cohort of steroid and TAC-resistant noncollapsing FSGS. The study included 22 cFSGS patients and 19 cases of steroid and TAC-resistant FSGS. Complete remission, partial remission, steroid resistance, progression to ESRD and death were observed in 13.6%, 4.5%, 27.3%, 36.4% and 18.2% patients, respectively. Patients with cFSGS had higher serum creatinine and more advanced tubulointerstitial changes compared to resistant FSGS. Twenty-six percent of therapy resistant noncollapsing FSGS progressed to ESRD after two years of stopping TAC. However, there was no difference in progression to ESRD between cFSGS and therapy-resistant noncollapsing FSGS at the end of two years. Glomerular collapse in the setting of FSGS is poorly responsive to treatment and has a high rate of progression to ESRD. The long-term prognosis of cFSGS and steroid and TAC-resistant FSGS are similar. PMID:27266801

  2. Changes in Neurofilament and Microtubule Distribution following Focal Axon Compression

    PubMed Central

    Fournier, Adam J.; Hogan, James D.; Rajbhandari, Labchan; Shrestha, Shiva; Venkatesan, Arun; Ramesh, K. T.

    2015-01-01

    Although a number of cytoskeletal derangements have been described in the setting of traumatic axonal injury (TAI), little is known of early structural changes that may serve to initiate a cascade of further axonal degeneration. Recent work by the authors has examined conformational changes in cytoskeletal constituents of neuronal axons undergoing traumatic axonal injury (TAI) following focal compression through confocal imaging data taken in vitro and in situ. The present study uses electron microscopy to understand and quantify in vitro alterations in the ultrastructural composition of microtubules and neurofilaments within neuronal axons of rats following focal compression. Standard transmission electron microscopy processing methods are used to identify microtubules, while neurofilament identification is performed using antibody labeling through gold nanoparticles. The number, density, and spacing of microtubules and neurofilaments are quantified for specimens in sham Control and Crushed groups with fixation at <1min following load. Our results indicate that the axon caliber dependency known to exist for microtubule and neurofilament metrics extends to axons undergoing TAI, with the exception of neurofilament spacing, which appears to remain constant across all Crushed axon diameters. Confidence interval comparisons between Control and Crushed cytoskeletal measures suggests early changes in the neurofilament spatial distributions within axons undergoing TAI may precede microtubule changes in response to applied loads. This may serve as a trigger for further secondary damage to the axon, representing a key insight into the temporal aspects of cytoskeletal degeneration at the component level, and suggests the rapid removal of neurofilament sidearms as one possible mechanism. PMID:26111004

  3. Adolescent focal theories: age-trends in developmental transitions

    PubMed

    Hendry; Glendinning; Shucksmith

    1996-08-01

    Focal theory is considered as a framework for looking at psychosocial and leisure transitions in middle and later adolescence. Although these transitions are examined from a different perspective in the present study, by utilising cross-sectional survey data from a representative sample of three age groups of young Scots (13-14, 15-16 and 17-18 year-olds), the results confirm and extend the general age-trends in relational issues and leisure involvement reported in original studies. Within this overall picture, few gender differences are found in age-related relational transitions, but gender differences are apparent in shifting focuses of leisure involvement with age. Further, the findings suggest a linkage between relational issues in adolescence and leisure contexts, where psychosocial processes are seen to be associated with contextual changes in young people's lives. Focal theory has been criticised for a failure to take true account of the social circumstances, constraints and contexts affecting adolescent development, but in the present study surprisingly few differences are found with respect to the young person's social class of family background, for example, with age-trends in developmental transitions similar for all social groups. By contrast, in later adolescence aspects of the young person's own socio-economic position, rather than that of their family background, are clearly linked to both relational issues and leisure involvement, for example, creating a disrupting effect on those young people who are currently unemployed or non-employed at this age. PMID:9245285

  4. Intracranial Cortical Calcifications in a Focal Epilepsy Patient with Pseudohypoparathyroidism.

    PubMed

    Kim, Ye Sel; Park, Jihyung; Park, Yoonkyung; Hwang, KyoungJin; Koo, Dae Lim; Kim, Daeyoung; Seo, Dae-Won

    2016-06-01

    Patients with chronic parathyroid dysfunction often have intracranial calcification in deep gray matter (GM) and subcortical white matter (WM) of their brain. Some of them are also epilepsy patients. Although cortical etiologies are main cause of epileptic seizure, cortical calcification has not been reported in these patients. We report a newly diagnosed focal epilepsy patient whose brain magnetic resonance imaging revealed intracranial calcifications in cortical as well as subcortical areas. Blood lab revealed that he had hypocalcemia due to pseudohypoparathyroidism. Video EEG monitoring revealed the ictal EEG mainly consist of polymorphic delta to theta waves with maximum at right temporal area followed by background attenuation and muscle artifacts. The interictal EEG showed multiple focal spike-wave discharges. After given oral calcium and calcitriol supplement, his calcium and phosphorous level normalized and he remains seizure free. This is the first case to show cortical calcification in a patient with pseudohypoparathyroidism. Cortical calcification could be an important measure of seizure burden in these patients and thus sophisticated imaging protocols should be used to visualize the extent of calcium deposits. PMID:27390678

  5. Allosteric regulation of focal adhesion kinase by PIP₂ and ATP.

    PubMed

    Zhou, Jing; Bronowska, Agnieszka; Le Coq, Johanne; Lietha, Daniel; Gräter, Frauke

    2015-02-01

    Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that regulates cell signaling, proliferation, migration, and development. A major mechanism of regulation of FAK activity is an intramolecular autoinhibitory interaction between two of its domains--the catalytic and FERM domains. Upon cell adhesion to the extracellular matrix, FAK is being translocated toward focal adhesion sites and activated. Interactions of FAK with phosphoinositide phosphatidylinsositol-4,5-bis-phosphate (PIP₂) are required to activate FAK. However, the molecular mechanism of the activation remains poorly understood. Recent fluorescence resonance energy transfer experiments revealed a closure of the FERM-kinase interface upon ATP binding, which is reversed upon additional binding of PIP₂. Here, we addressed the allosteric regulation of FAK by performing all-atom molecular-dynamics simulations of a FAK fragment containing the catalytic and FERM domains, and comparing the dynamics in the absence or presence of ATP and PIP₂. As a major conformational change, we observe a closing and opening motion upon ATP and additional PIP₂ binding, respectively, in good agreement with the fluorescence resonance energy transfer experiments. To reveal how the binding of the regulatory PIP₂ to the FERM F2 lobe is transduced to the very distant F1/N-lobe interface, we employed force distribution analysis. We identified a network of mainly charged residue-residue interactions spanning from the PIP₂ binding site to the distant interface between the kinase and FERM domains, comprising candidate residues for mutagenesis to validate the predicted mechanism of FAK activation. PMID:25650936

  6. Technological developments of the OGRE focal plane array

    NASA Astrophysics Data System (ADS)

    Tutt, James H.; McEntaffer, Randall L.; DeRoo, Casey; Schultz, Ted; Rogers, Thomas; Murray, Neil; Holland, Andrew; Weatherill, Daniel; Holland, Karen; Colebrook, David; Farn, David

    2015-09-01

    The Off-plane Grating Rocket Experiment (OGRE) is a high resolution soft X-ray spectrometer sub-orbital rocket payload designed as a technology development platform for three low Technology Readiness Level (TRL) components. The incident photons will be focused using a light-weight, high resolution, single-crystal silicon optic. They are then dispersed conically according to wavelength by an array of off-plane gratings before being detected in a focal plane camera comprised of four Electron Multiplying Charge-Coupled Devices (EM-CCDs). While CCDs have been extensively used in space applications; EM-CCDs are seldom used in this environment and even more rarely for X-ray photon counting applications, making them a potential technology risk for larger scale X-ray observatories. This paper will discuss the reasons behind choosing EM-CCDs for the focal plane detector and the developments that have been recently made in the prototype camera electronics and thermal control system.

  7. High operating temperature interband cascade focal plane arrays

    SciTech Connect

    Tian, Z.-B.; Godoy, S. E.; Kim, H. S.; Schuler-Sandy, T.; Montoya, J. A.; Krishna, S.

    2014-08-04

    In this paper, we report the initial demonstration of mid-infrared interband cascade (IC) photodetector focal plane arrays with multiple-stage/junction design. The merits of IC photodetectors include low noise and efficient photocarrier extraction, even for zero-bias operation. By adopting enhanced electron barrier design and a total absorber thickness of 0.7 μm, the 5-stage IC detectors show very low dark current (1.10 × 10{sup −7} A/cm{sup 2} at −5 mV and 150 K). Even with un-optimized fabrication and standard commercial (mis-matched) read-out circuit technology, infrared images are obtained by the 320 × 256 IC focal plane array up to 180 K with f/2.3 optics. The minimum noise equivalent temperature difference of 28 mK is obtained at 120 K. These initial results indicate great potential of IC photodetectors, particularly for high operating temperature applications.

  8. Radiometric infrared focal plane array imaging system for thermographic applications

    NASA Technical Reports Server (NTRS)

    Esposito, B. J.; Mccafferty, N.; Brown, R.; Tower, J. R.; Kosonocky, W. F.

    1992-01-01

    This document describes research performed under the Radiometric Infrared Focal Plane Array Imaging System for Thermographic Applications contract. This research investigated the feasibility of using platinum silicide (PtSi) Schottky-barrier infrared focal plane arrays (IR FPAs) for NASA Langley's specific radiometric thermal imaging requirements. The initial goal of this design was to develop a high spatial resolution radiometer with an NETD of 1 percent of the temperature reading over the range of 0 to 250 C. The proposed camera design developed during this study and described in this report provides: (1) high spatial resolution (full-TV resolution); (2) high thermal dynamic range (0 to 250 C); (3) the ability to image rapid, large thermal transients utilizing electronic exposure control (commandable dynamic range of 2,500,000:1 with exposure control latency of 33 ms); (4) high uniformity (0.5 percent nonuniformity after correction); and (5) high thermal resolution (0.1 C at 25 C background and 0.5 C at 250 C background).

  9. Selective platelet deposition during focal cerebral ischemia in the monkey

    SciTech Connect

    Feinberg, H.; Crowell, R.M.; Jafar, J.J.; Marmo, F.; Gandhi, Y.; Mosher, J.L.; Le Breton, G.C.

    1986-03-01

    Platelet thrombosis in the microcirculation may play a central role in focal cerebral ischemia. The authors investigated platelet deposition after temporary middle cerebral artery (MCA) occlusion in the monkey. Anesthetized monkeys were infused with autologous /sup 111/In-labeled platelets and /sup 51/Cr-labeled red cells in order to measure platelet deposition independent of hemorrhage. The right MCA was occluded for 6 hrs with a clip via a trans-orbital approach. Following clip removal, reperfusion was carried out for 45 min after which the animal was sacrificed. Brain samples were assayed for platelet deposition in selected areas of the right and left hemispheres (RH, LH). Net platelet deposition was determined from the excess /sup 111/In counts above that contained in blood (as determined by /sup 51/Cr counts). It was found that ischemia resulted in selective platelet deposition in the area of the occluded MCA, i.e. the RH versus the corresponding areas in the LH. Differences between the RH and the LH were found in the (1) caudate nucleus, (2) internal capsule and (3) putamen. The data suggest that focal ischemia is associated with the activation of platelets in the ischemic area.

  10. Unusual focal keratin expression in plexiform angiomyxoid myofibroblastic tumor

    PubMed Central

    Quero, Giuseppe; Musarra, Teresa; Carrato, Alfredo; Fici, Michelangelo; Martini, Maurizio; Dei Tos, Angelo Paolo; Alfieri, Sergio; Ricci, Riccardo

    2016-01-01

    Abstract Background: Plexiform angiomyxoid myofibroblastic tumor (PAMT), also known as plexiform fibromyxoma, is a rare distinctive benign intramural tumor, typical of gastric antrum, commonly causing mucosal ulceration with upper gastrointestinal bleeding and anemia, effectively treated by complete surgical resection usually accomplished by distal gastrectomy. Methods and Results: We herein report a 47-year-old man presenting with a syncopal episode, regurgitation and epigastric discomfort, bearing a gastric antral myxoid plexiform tumor positive for α-smooth muscle actin, vimentin and, partially, for caldesmon, desmin, and CD10; CD117, DOG1, CD34, S100, CAM5.2, CK20, CK7, EMA, p53, CDX2, chromogranin A, synaptophysin, anaplastic lymphoma kinase, Melan-A, and HMB-45 were all negative. All these features are typical of PAMT. Of note, focal positivity for AE1/AE3 and pan-CK KL1 was also present. Conclusions: The finding of a focal keratin expression in PAMT contributes to enlarge the immunophenotypic spectrum of this tumor type and is relevant for avoiding presurgical misdiagnoses which could ultimately lead to inappropriate overtreatment of patients with PAMT. PMID:27428222

  11. Refractive beryllium x-ray lens with variable focal length

    NASA Astrophysics Data System (ADS)

    Cederstroem, Bjoern; Danielsson, Mats; Lundqvist, Mats

    2001-01-01

    A refractive lens for hard X-rays comprising two saw-tooth profiles is presented. This lens has the same focusing properties as a parabolic compound refractive lens. One advantage is the remarkably low fabrication cost, since curved surfaces are replaced by planar ones. In addition, the focal length of the lens can be easily varied by adjusting the angle between the two halves. Since the index of refraction depends on the X-ray energy, the lens is chromatic and acts as a band- pass filter for a broad energy spectrum. Combined with the tunability of the focal length, this allows versatile spectral shaping of the X-ray beam. Calculations and numerical examples of the focusing properties are presented. Due to its low atomic number, beryllium is an excellent choice for refractive optics and a prototype in beryllium has been fabricated using diamond turning technique. Surface metrology shows a deviation from the ideal shape of about 400 nm rms, indicating a loss of intensity of between 20% and 50%, depending on the geometry an X-ray energy.

  12. Cardiac Dysfunction After Left Permanent Cerebral Focal Ischemia

    PubMed Central

    Min, Jiangyong; Farooq, Muhammad U.; Greenberg, Eric; Aloka, Feras; Bhatt, Archit; Kassab, Mounzer; Morgan, James P.; Majid, Arshad

    2010-01-01

    Background and Purpose Stroke can lead to cerebrogenic cardiac arrhythmias. We sought to investigate the effect of ischemic stroke on cardiac function in a mouse model of permanent middle cerebral artery occlusion (pMCAO). Methods Twenty-four hours after the induction of focal ischemia, cardiac function was measured in mice by endovascular catheterization of the heart. Immediately after hemodynamic measurements, mice were euthanized and brains were excised and sectioned to measure infarct volume and the severity of insular cortex injury. Myocardial damage was evaluated by hematoxylin-eosin staining. Serum and heart levels of norepinephrine (NE) were also determined. Results Cardiac dysfunction occurred in 9 out of 14 mice that underwent left pMCAO. In these 9 mice, the severity of left insular cortex lesion was greater than the mice with normal heart function. The serum and heart levels of NE were significantly higher in left pMCAO mice with heart dysfunction. Liner regression analysis indicates significant inverse correlation between the severity of left insular cortex damage and heart dysfunction. Mice that underwent right pMCAO did not exhibit cardiac dysfunction. Conclusions This study shows that left focal cerebral ischemia can produce cardiac dysfunction, which is associated with the extent of left insular cortex damage. Furthermore, mice exhibiting cardiac dysfunction had elevated levels of NE in the serum and heart. PMID:19443809

  13. Ambient and focal visual processing of naturalistic activity.

    PubMed

    Eisenberg, Michelle L; Zacks, Jeffrey M

    2016-01-01

    When people inspect a picture, they progress through two distinct phases of visual processing: an ambient, or exploratory, phase that emphasizes input from peripheral vision and rapid acquisition of low-frequency information, followed by a focal phase that emphasizes central vision, salient objects, and high-frequency information. Does this qualitative shift occur during dynamic scene viewing? If so, when? One possibility is that shifts to exploratory processing are triggered at subjective event boundaries. This shift would be adaptive, because event boundaries typically occur when activity features change and when activity becomes unpredictable. Here, we used a perceptual event segmentation task, in which people identified boundaries between meaningful units of activity, to test this hypothesis. In two studies, an eye tracker recorded eye movements and pupil size while participants first watched movies of actors engaged in everyday activities and then segmented them into meaningful events. Saccade amplitudes and fixation durations during the initial viewings suggest that event boundaries function much like the onset of a new picture during static picture presentation: Viewers initiate an ambient processing phase and then progress to focal viewing as the event progresses. These studies suggest that this shift in processing mode could play a role in the formation of mental representations of the current environment. PMID:27002550

  14. Focal pregnancy-like changes in the breast.

    PubMed

    Kiaer, H W; Andersen, J A

    1977-11-01

    The aetiology of focal, preganancy-like mammary changes in non-pregnant and non-lactating women is discussed on the basis of the literature and a material of 31 patients. Such changes were found in one or more glandular lobules in 3 per cent of the breast tissue specimens received in our departments. As a rule, this finding was made in women who had been pregnant and who had been or were on oestrogenic or on contraceptive medication. They occurred in fertile, menopausal, as well as in post-menopausal women. Often they were seen many years after the pregnancy and/or intake of hormones. They were observed also in women who had never been pregnant or on hormone medication, and even in men on oestrogen therapy. It is likely, therefore, that focal pregnancy-like changes in non-pregnant and non-lactating women indicate a selective susceptibility of the mammary glandular tissue to oestrogen. Accordingly, we interpret the change as a normal histological variant. PMID:602779

  15. Improving HST Pointing & Absolute Astrometry

    NASA Astrophysics Data System (ADS)

    Lallo, Matthew; Nelan, E.; Kimmer, E.; Cox, C.; Casertano, S.

    2007-05-01

    Accurate absolute astrometry is becoming increasingly important in an era of multi-mission archives and virtual observatories. Hubble Space Telescope's (HST's) Guidestar Catalog II (GSC2) has reduced coordinate error to around 0.25 arcsecond, a factor 2 or more compared with GSC1. With this reduced catalog error, special attention must be given to calibrate and maintain the Fine Guidance Sensors (FGSs) and Science Instruments (SIs) alignments in HST to a level well below this in order to ensure that the accuracy of science product's astrometry keywords and target positioning are limited only by the catalog errors. After HST Servicing Mission 4, such calibrations' improvement in "blind" pointing accuracy will allow for more efficient COS acquisitions. Multiple SIs and FGSs each have their own footprints in the spatially shared HST focal plane. It is the small changes over time in primarily the whole-body positions & orientations of these instruments & guiders relative to one another that is addressed by this work. We describe the HST Cycle 15 program CAL/OTA 11021 which, along with future variants of it, determines and maintains positions and orientations of the SIs and FGSs to better than 50 milli- arcseconds and 0.04 to 0.004 degrees of roll, putting errors associated with the alignment sufficiently below GSC2 errors. We present recent alignment results and assess their errors, illustrate trends, and describe where and how the observer sees benefit from these calibrations when using HST.

  16. Practical considerations for pointing a binocular telescope

    NASA Astrophysics Data System (ADS)

    De La Peña, Michele D.; Terrett, David L.; Thompson, David; Biddick, Christopher J.

    2010-07-01

    The Large Binocular Telescope (LBT) consists of two 8.4-meter primary mirrors on a common mount. When the telescope is complete, to complement the two primaries there will be two 0.9-meter adaptive secondaries and two tertiary mirror flats that all work to support a variety of Gregorian focal stations, as well as prime focus. A fundamental goal of the telescope is to perform interferometric observations, and therefore, there is a critical need for the ability to co-point the individual telescopes to high precision. Further, a unique aspect of the LBT is the comparatively large range over which the optics can be adjusted which provides flexibility for the acquisition of targets. In the most general case, an observer could be performing an observation using different targets, within constraints, with different instruments on each of the two telescope sides, with different observing duty cycles. As a consequence of the binocular nature of the telescope and the number of possible observing combinations, there are unique requirements imposed on the Telescope Control System (TCS), and in particular, on the Pointing Control Subsystem (PCS). It is the responsibility of the PCS to arbitrate the pointing requests made on the two sides of the telescope by the observers, incorporate guide updates, and generate tracking trajectories for the mount and the rotators, in conjunction with providing tip/tilt demands on the subsystem controlling the optical elements, and ensure each target remains on the specified location (i.e., pointing origin) in the focal plane during an active observation. This paper describes the current design and implementation of the LBT PCS.

  17. Multi-resolution low-power Gaussian filtering by reconfigurable focal-plane binning

    NASA Astrophysics Data System (ADS)

    Fernández-Berni, J.; Carmona-Galán, R.; Pozas-Flores, F.; Zarándy, Á.; Rodríguez-Vázquez, Á.

    2011-05-01

    Gaussian filtering is a basic tool for image processing. Noise reduction, scale-space generation or edge detection are examples of tasks where different Gaussian filters can be successfully utilized. However, their implementation in a conventional digital processor by applying a convolution kernel throughout the image is quite inefficient. Not only the value of every single pixel is taken into consideration sucessively, but also contributions from their neighbors need to be taken into account. Processing of the frame is serialized and memory access is intensive and recurrent. The result is a low operation speed or, alternatively, a high power consumption. This inefficiency is specially remarkable for filters with large variance, as the kernel size increases significantly. In this paper, a different approach to achieve Gaussian filtering is proposed. It is oriented to applications with very low power budgets. The key point is a reconfigurable focal-plane binning. Pixels are grouped according to the targeted resolution by means of a division grid. Then, two consecutive shifts of this grid in opposite directions carry out the spread of information to the neighborhood of each pixel in parallel. The outcome is equivalent to the application of a 3×3 binomial filter kernel, which in turns is a good approximation of a Gaussian filter, on the original image. The variance of the closest Gaussian filter is around 0.5. By repeating the operation, Gaussian filters with larger variances can be achieved. A rough estimation of the necessary energy for each repetition until reaching the desired filter is below 20nJ for a QCIF-size array. Finally, experimental results of a QCIF proofof- concept focal-plane array manufactured in 0.35μm CMOS technology are presented. A maximum RMSE of only 1.2% is obtained by the on-chip Gaussian filtering with respect to the corresponding equivalent ideal filter implemented off-chip.

  18. Differential Neuroprotective Effects of Carnosine, Anserine, and N-Acetyl Carnosine against Permanent Focal Ischemia

    PubMed Central

    Min, Jiangyong; Senut, Marie-Claude; Rajanikant, Krishnamurthy; Greenberg, Eric; Bandagi, Ram; Zemke, Daniel; Mousa, Ahmad; Kassab, Mounzer; Farooq, Muhammad U.; Gupta, Rishi; Majid, Arshad

    2009-01-01

    Carnosine (β-alanyl-L-histidine) has been shown to exhibit neuroprotection in rodent models of cerebral ischemia. In the present study, we further characterized the effects of carnosine treatment in a mouse model of permanent focal cerebral ischemia and compared them with its related peptides anserine and N-acetylated carnosine. We also evaluated the efficacy of bestatin, a carnosinase inhibitor, in ameliorating ischemic brain damage. Permanent focal cerebral ischemia was induced by occlusion of the middle cerebral artery (pMCAO). Mice were subsequently randomly assigned to receive an intraperitoneal injection of vehicle (0.9% saline), carnosine, N-acetyl carnosine, anserine, bestatin alone, or bestatin with carnosine. Infarct size was examined using 2,3,5-triphenyltetrazolium chloride staining 1, 3, and 7 days following pMCAO, and neurological function was evaluated using an 18-point-based scale. Brain levels of carnosine were measured in treated mice using high-performance liquid chromatography 1 day following pMCAO. We demonstrated that treatment with carnosine, but not its analogues, was able to significantly reduce infarct volume and improve neurological function compared with those in vehicle-treated mice. These beneficial effects were maintained for 7 days post-pMCAO. In contrast, compared with the vehicle-treated group, bestatin-treated mice displayed an increase in the severity of ischemic lesion, which was prevented by the addition of carnosine. These new data further characterize the neuroprotective effects of carnosine and suggest that carnosine may be an attractive candidate for testing as a stroke therapy. PMID:18543335

  19. Hotspot quantification of myocardial focal tracer uptake from molecular targeted SPECT/CT images: experimental validation

    NASA Astrophysics Data System (ADS)

    Liu, Yi-Hwa; Sahul, Zakir; Weyman, Christopher A.; Ryder, William J.; Dione, Donald P.; Dobrucki, Lawrence W.; Mekkaoui, Choukri; Brennan, Matthew P.; Hu, Xiaoyue; Hawley, Christi; Sinusas, Albert J.

    2008-03-01

    We have developed a new single photon emission computerized tomography (SPECT) hotspot quantification method incorporating extra cardiac activity correction and hotspot normal limit estimation. The method was validated for estimation accuracy of myocardial tracer focal uptake in a chronic canine model of myocardial infarction (MI). Dogs (n = 4) at 2 weeks post MI were injected with Tl-201 and a Tc-99m-labeled hotspot tracer targeted at matrix metalloproteinases (MMPs). An external point source filled with Tc-99m was used for a reference of absolute radioactivity. Dual-isotope (Tc-99m/Tl-201) SPECT images were acquired simultaneously followed by an X-ray CT acquisition. Dogs were sacrificed after imaging for myocardial gamma well counting. Images were reconstructed with CT-based attenuation correction (AC) and without AC (NAC) and were quantified using our quantification method. Normal limits for myocardial hotspot uptake were estimated based on 3 different schemes: maximum entropy, meansquared-error minimization (MSEM) and global minimization. Absolute myocardial hotspot uptake was quantified from SPECT images using the normal limits and compared with well-counted radioactivity on a segment-by-segment basis (n = 12 segments/dog). Radioactivity was expressed as % injected dose (%ID). There was an excellent correlation (r = 0.78-0.92) between the estimated activity (%ID) derived using the SPECT quantitative approach and well-counting, independent of AC. However, SPECT quantification without AC resulted in the significant underestimation of radioactivity. Quantification using SPECT with AC and the MSEM normal limit yielded the best results compared with well-counting. In conclusion, focal myocardial "hotspot" uptake of a targeted radiotracer can be accurately quantified in vivo using a method that incorporates SPECT imaging with AC, an external reference, background scatter compensation, and a suitable normal limit. This hybrid SPECT/CT approach allows for the serial

  20. X-4 in flight

    NASA Technical Reports Server (NTRS)

    1951-01-01

    a wealth of data, and the cost of repairing the leak could not be justified. Although the X-4 was never designed to fly at supersonic speeds, it gathered transonic data that proved that conventional tailless swept-wing configurations were unsuitable for supersonic performance. The design suffered from noticeable instability in all directions, increasing as it approached the speed of sound. It was, however, a valuable tool for dynamic stability research. Additionally low lift-to-drag data gathered with the X-4 was later beneficial to development of the X-15. On 10 March 1954, both X-4 aircraft were returned to the Air Force. The ejection seat from the second X-4 was retained by the NACA for use in the X-1E. The first X-4 is currently on display at the United States Air Force Academy in Colorado. The second aircraft is displayed at the USAF Museum in Ohio. This movie clip running approximately 7 seconds shows the Northrop X-4 in an air-to-air view climbing away from its chase aircraft.

  1. Friction coefficient of faults inferred from earthquake focal mechanisms

    NASA Astrophysics Data System (ADS)

    Viganò, Alfio; Ranalli, Giorgio; Andreis, Daniele; Martin, Silvana; Rigon, Riccardo

    2013-04-01

    In earthquake mechanics and structural geology the static friction coefficient is usually assumed to have the laboratory value (μ = 0.6-0.8) according to the Coulomb-Byerlee's law. Estimates from deep boreholes and/or natural faults generally confirm this hypothesis but in some cases friction coefficients can be significantly lower, suggesting the existence of weak faults able to be activated by lower effective stress than theoretically expected. We apply a modified version of the method proposed by Yin and Ranalli (1995, Journal of Structural Geology, vol. 17, pp. 1327-1335), where the average friction coefficient of a set of n faults is estimated. This method is based on minimization of the sum of squares of the misfit ratios, where the misfit ratio of each fault is given dividing the misfit stress difference (i.e. the misfit between normalized stress difference and average normalized stress difference) by the average normalized stress difference. The normalized stress difference is defined as the critical stress difference divided by the effective overburden pressure, while the average stress difference is obtained considering the entire fault dataset. Input data are (i) the orientation of faults, (ii) the stress field orientation, and (iii) the stress ratio. The latter two must be independently estimated. A uniform stress field and a similar normalized critical stress difference for the fault dataset are assumed. The procedure has been extended to apply to fault plane solutions by considering both nodal planes of a set of n focal mechanisms and estimating the range of acceptable average friction coefficients from all possible combination of planes (2n number of combinations). The amount of calculation can be considerably reduced if independent information makes it possible to select which one of the nodal planes of each focal mechanism is the true fault plane (for example when aftershocks delineate the fault geometry at depth), resulting in only n combinations

  2. Velocity Inhomogeneity of The Seismic Focal Zone In Kamchatka

    NASA Astrophysics Data System (ADS)

    Sanina, I.; Gontovaya, L.; Levina, V.; Stepanova, M.

    Kamchatka is situated in the junction zone of Kuril-Kamchatka and Aleutian island arcs. According to P.R.Vogt et.al the geometry of this conjunction is determined by the Hawaiian-Emperor Volcanic Seamount Chain. The Kluchevsky volcanic group be- longs to intersection of these structures on the Kamchatka Peninsula. Due to high yield of magmatic material this group can be considered as one of the so-called hot spots on Earth. We studied the velocity structure of the Earth's crust and upper mantle in the transition zone continent-Pacific Ocean up to the depth about 120 km. 3-D veloc- ity structure is reconstructed by seismic tomography method (SSA modification). We used regional catalogue of Kamchatka earthquakes for the period 1975-1999 recorded by 35 seismological stations within the territory of Kamchatka (Kuril-Kamchatka is- land arc) and the Bering Island. Data are carefully selected according to special re- quirements on depth, magnitude, accuracy in coordinates and origin time. The amount of data provides high resolution of observation pattern and accuracy of obtained veloc- ity residuals. Distributions of Vp and Vs velocities are presented for the depth ranges 0-20, 20-35, 35-60, 60-90 and 90-120 km, and for vertical crossections along and across the Kuril-Kamchatka island arc. Significant lateral and vertical inhomogeneity of the seismic focal zone is revealed. We identify narrow steep dipping low velocity zones, related to deep faults with continuation on the Peninsula. These zones sepa- rate crust and mantle blocks with high contrast within the focal layer. Usually strong earthquakes are related to these boundaries. The conjunction zone of the island arc and the Emperor fault (its continuation under Kamchatka) coincides with the low velocity zone in the mantle at depth 60-90 km, continued in the continental block. A chain of volcanoes oriented across Eastern-Kamchatka volcanic belt is related to this zone. Volcanic belt on the whole is shifted westwards in

  3. Mid-Wave and Long-Wave Infrared Dualband Megapixel QWIP Focal Plane Array

    NASA Technical Reports Server (NTRS)

    Gunapala, S. D.; Bandara, S. V.; Liu, J. K.; Mumolo, J. M.; Hill, C. J.; Ting, D. Z.; Kurth, E.; Woolaway, J.; LeVan, P. D.; Tidrow, M. Z.

    2008-01-01

    Mid-wavelength infrared (MWIR) and long-wavelength infrared (LWIR) 1024x1024 pixel InGaAs/GaAs/AlGaAs based quantum well infrared photodetector (QWIP) focal planes and a 320x256 pixel dual-band pixel co-registered simultaneous QWIP focal plane array have been demonstrated as pathfinders. In this paper, we discuss the development of 1024x1024 MWIR/LWIR dual-band pixel co-registered simultaneous QWIP focal plane array.

  4. Measurement of focal length using phase shifted moiré deflectometry

    NASA Astrophysics Data System (ADS)

    Trivedi, Satyaprakash; Dhanotia, Jitendra; Prakash, Shashi

    2013-06-01

    In present communication, a simple technique for determining the focal length using moiré deflectometry has been proposed. Necessary mathematical premise expressing the focal length of lens in terms of defocusing distance and the slope of wavefront phase has been deduced. Using a four-step phase shifting technique the testing procedure for determining the focal length has been demonstrated. Uncertainty in measurement has been estimated. Good co-relation between the measured value and the standard value has been obtained.

  5. A C++ class library for telescope pointing

    NASA Astrophysics Data System (ADS)

    Terrett, David L.

    2006-06-01

    tpk is a C++ class library, layered on TCSpk and slalib that implements virtual telescope objects for generating mount and rotator position (and optionally, velocity and acceleration) demands, predicting the position of guide probes etc. in the focal plane and tip and tilt for steerable optics. These objects allocate and manage storage for the kernel context in a thread safe manner enabling a pointing kernel for a specific telescope configuration to be constructed simply by creating the necessary objects and calling their "fast", "medium" and "slow" update methods at the appropriate rates. Additional facilities include: Tracking of solar system objects using orbital elements as tabulated by the Minor Planet Center, the JPL Horizons system and the Astronomical Almanac or the for the major planets, built-in ephemeredes due to Chapront and Francou - Management of pointing models including the logging of pointing test data capable of being read into TPOINT, catalogues of pointing reference stars and pointing adjustments from handsets and guiders including the necessary digital filters - Generation of world coordinate system mappings and FITS keywords for instruments. The library can be tailored for a particular operating environment by replacing the mutex and clock classes. For "off-line" or otherwise non time-critical application the existing Posix and Windows implementations can be used.

  6. Diffraction of high-intensity field in focal region as dynamics of nonlinear system with low-frequency dispersion

    NASA Astrophysics Data System (ADS)

    Rudenko, O. V.; Hedberg, C. M.

    2015-01-01

    The stationary profile in the focal region of a focused nonlinear acoustic wave is described. Three models following from the Khokhlov-Zabolotskaya (KZ) equation with three independent variables are used: (i) the simplified one-dimensional Ostrovsky-Vakhnenko equation, (ii) the system of equations for paraxial series expansion of the acoustic field in powers of transverse coordinates, and (iii) the KZ equation reduced to two independent variables. The structure of the last equation is analogous to the Westervelt equation. Linearization through the Legendre transformation and reduction to the well-studied Euler-Tricomi equation is shown. At high intensities the stationary profiles are periodic sequences of arc sections having singularities of derivative in their matching points. The occurrence of arc profiles was pointed out by Makov. These appear in different nonlinear systems with low-frequency dispersion. Profiles containing discontinuities (shock fronts) change their form while passing through the focal region and are non-stationary waves. The numerical estimations of maximum pressure and intensity in the focus agree with computer calculations and experimental measurements.

  7. The Effects of Antecedent Exercise on Motor Function Recovery and Brain-derived Neurotrophic Factor Expression after Focal Cerebral Ischemia in Rats

    PubMed Central

    Kim, Gyeyeop; Kim, Eunjung

    2013-01-01

    [Purpose] In the present study, we investigated the effect of antecedent exercise on functional recovery and brain-derived neurotrophic factor (BDNF) expression following focal cerebral ischemia injury. [Subjects] The rat middle cerebral artery occlusion (MCAO) model was employed. Adult male Sprague-Dawley rats were randomly divided into 4 groups. Group I included untreated normal rats (n=10); Group II included untreated rats with focal cerebral ischemia (n=10); Group III included rats that performed treadmill exercise (20 m/min) training after focal cerebral ischemia (n=10); and Group IV included rats that performed antecedent treadmill exercise (20 m/min) training before focal cerebral ischemia (n=10) as well as treadmill exercise after ischemia. At different time points (1, 7, 14, and 21 days) Garcia’s score, and the hippocampal expressions level of BDNF were examined. [Results] In the antecedent exercise group, improvements in the motor behavior index (Garcia’s score) were observed and hippocampal BDNF protein expression levels increased. [Conclusion] These results indicate that antecedent treadmill exercise, before permanent brain ischemia exerts a neuroprotective effect against ischemia brain injury by improving motor performance and increasing the level of BDNF expression. Furthermore, the antecedent treadmill exercise of appropriate intensity is critical for post-stroke rehabilitation. PMID:24259800

  8. α-Actinin-4 Enhances Colorectal Cancer Cell Invasion by Suppressing Focal Adhesion Maturation

    PubMed Central

    Yamada, Tesshi; Takenawa, Tadaomi

    2015-01-01

    α-Actinins (ACTNs) are known to crosslink actin filaments at focal adhesions in migrating cells. Among the four isoforms of mammalian ACTNs, ACTN1 and ACTN4 are ubiquitously expressed. Recently, ACTN4 was reported to enhance cancer cell motility, invasion, and metastasis. However, the mechanism by which ACTN4 drives these malignant phenotypes remains unclear. Here, we show that ACTN4, but not ACTN1, induces the formation of immature focal adhesions in DLD-1 cells, leading to the rapid turnover of focal adhesions. Interestingly, zyxin (ZYX) assembly to focal adhesions was markedly decreased in ACTN4-expressing DLD-1 cells, while the recruitment of paxillin (PAX) occurred normally. On the other hand, in ACTN1-expressing DLD-1 cells, PAX and ZYX were normally recruited to focal adhesions, suggesting that ACTN4 specifically impairs focal adhesion maturation by inhibiting the recruitment of ZYX to focal complexes. Using purified recombinant proteins, we found that ZYX binding to ACTN4 was defective under conditions where ZYX binding to ACTN1 was observed. Furthermore, Matrigel invasion of SW480 cells that express high endogenous levels of ACTN4 protein was inhibited by ectopic expression of ACTN1. Altogether, our results suggest that ZYX defective binding to ACTN4, which occupies focal adhesions instead of ACTN1, induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion. PMID:25860875

  9. Future directions in focal-plane signal processing for space-borne scientific imagers

    NASA Technical Reports Server (NTRS)

    Fossum, Eric R.

    1991-01-01

    The potential of focal-plane signal processing for space-borne scientific imagers is discussed. Significant improvement in image quality and consequent scientific return may be enabled through the utilization of focal-plane signal processing techniques. The possible application of focal-plane signal processing to readout noise reduction, cosmic ray circumvention, non-uniformity correction, and throughput enhancement is described. On-focal-plane analog-to-digital (A/D) conversion and micromotion stabilization are also discussed. It is the intention of this paper to stimulate further thought and efforts in this field.

  10. Behavior of asymmetric Bessel beam in focal plane of high numerical aperture objective

    NASA Astrophysics Data System (ADS)

    Stafeev, Sergey S.; Kotlyar, Victor V.; Porfirev, Alexey P.

    2016-04-01

    Tight focusing of a linearly-polarized asymmetric Bessel beam, which has a crescent profile, was investigated numerically and experimentally. FDTD calculations show that a binary zone plate of numerical aperture NA = 0.995 forms a crescent in the focal plane, which is rotated clockwise around the optical axis, moving away from the focal plane. Using the Debye formulae it was shown that a direction of polarization of incident light has a significant influence on intensity distribution in focal plane. The crescent in the focal plane was also observed experimentally by focusing of the asymmetric Bessel beam using an immersive objective (NA = 1.25).

  11. Thermal and mechanical architecture for the SAFARI focal plane assembly

    NASA Astrophysics Data System (ADS)

    Martignac, J.

    2010-07-01

    The very challenging SPICA/SAFARI scientific goals imply to cool most detector solutions below 100 mK. This implies to find reliable solutions providing not only very efficient thermal insulation between the different temperature stages, but also keeping the stray light level well below the foreseen astronomical background (20 aW/pixel !). The main constraint is the available power budget (1-2μW) this value includes optical, electrical and parasitic power loads. This poster describes how the Herschel/PACS Bolometer Focal Plane thermo-mechanical design can be adapted to the new thermal and optical needs, while keeping a sufficiently stiff structure to withstand launch vibrations. We give the first results on the thermal and mechanical behaviour obtained with a prototype.

  12. Magnetic Resonance Image-Guided Focal Prostate Ablation.

    PubMed

    Nour, Sherif G

    2016-09-01

    Prostate cancer is the most common cancer (other than skin cancer) in American men, with one in seven men being diagnosed with this disease during his lifetime. The estimated number of new prostate cancer cases in 2016 is 180,890. For the first time, imaging has become the center of the search for contained, intraglandular, small-volume, and unifocal disease, and an increasing number of academic institutions as well as private practices are implementing programs for prostate multiplanar magnetic resonance imaging (MRI) as parts of their routine offerings. This article reviews the role of MRI-guided focal prostate ablation, as well as opportunities for further growth in this minimally invasive therapy of prostate cancer. PMID:27582608

  13. Optical-based spectral modeling of infrared focal plane arrays

    NASA Astrophysics Data System (ADS)

    Mouzali, Salima; Lefebvre, Sidonie; Rommeluère, Sylvain; Ferrec, Yann; Primot, Jérôme

    2016-07-01

    We adopt an optical approach in order to model and predict the spectral signature of an infrared focal plane array. The modeling is based on a multilayer description of the structure and considers a one-dimensional propagation. It provides a better understanding of the physical phenomena occurring within the pixels, which is useful to perform radiometric measurements, as well as to reliably predict the spectral sensitivity of the detector. An exhaustive model is presented, covering the total spectral range of the pixel response. A heuristic model is also described, depicting a complementary approach that separates the different optical phenomena inside the pixel structure. Promising results are presented, validating the models through comparison with experimental results. Finally, advantages and limitations of this approach are discussed.

  14. Focally regulated endothelial proliferation and cell death in human synovium.

    PubMed Central

    Walsh, D. A.; Wade, M.; Mapp, P. I.; Blake, D. R.

    1998-01-01

    Angiogenesis and vascular insufficiency each may support the chronic synovial inflammation of rheumatoid arthritis. We have shown by quantitative immunohistochemistry and terminal uridyl deoxynucleotide nick end labeling that endothelial proliferation and cell death indices were each increased in synovia from patients with rheumatoid arthritis compared with osteoarthritic and noninflamed controls, whereas endothelial fractional areas did not differ significantly among disease groups. Markers of proliferation were associated with foci immunoreactive for vascular endothelial growth factor and integrin alpha(v)beta3, whereas cell death was observed in foci in which immunoreactivities for these factors were weak or absent. No association was found with thrombospondin immunoreactivity. The balance between angiogenesis and vascular regression in rheumatoid synovitis may be determined by the focal expression of angiogenic and endothelial survival factors. Increased endothelial cell turnover may contribute to microvascular dysfunction and thereby facilitate persistent synovitis. Images Figure 1 Figure 3 Figure 4 PMID:9502411

  15. Focal dysplasia of the cerebral cortex in epilepsy

    PubMed Central

    Taylor, D. C.; Falconer, M. A.; Bruton, C. J.; Corsellis, J. A. N.

    1971-01-01

    An unusual microscopic abnormality has been identified in the lobectomy specimens removed surgically from the brains of 10 epileptic patients. The abnormality could seldom be identified by palpation or with the naked eye. Histologically, it consisted of congregations of large, bizarre neurones which were littered through all but the first cortical layer. In most, but not in all cases, grotesque cells, probably of glial origin, were also present in the depths of the affected cortex and in the subjacent white matter. This kind of abnormality appears to be a malformation. The picture is reminiscent of tuberous sclerosis but too many distinguishing features, both in the clinical and in the pathological aspects, make this diagnosis untenable. The cases are therefore looked on provisionally (since all but one are still alive) as comprising a distinct form of cortical dysplasia in which localized, exotic populations of nerve cells underlie the electrical and clinical manifestations of certain focal forms of epilepsy. Images PMID:5096551

  16. MEG-based imaging of focal neuronal current sources

    SciTech Connect

    Phillips, J.W.; Leahy, R.M.; Mosher, J.C.

    1997-06-01

    The authors describe a new approach to imaging neural current sources from measurements of the magnetoencephalogram (MEG) associated with sensory, motor, or cognitive brain activation. Many previous approaches to this problem have concentrated on the use of weighted minimum norm (WMN) inverse methods. While these methods ensure a unique solution, they do not introduce information specific to the MEG inverse problem, often producing overly smoothed solutions and exhibiting severe sensitivity to noise. The authors describe a Bayesian formulation of the inverse problem in which a Gibbs prior is constructed to reflect the sparse focal nature of neural current sources associated with evoked response data. They demonstrate the method with simulated and experimental phantom data, comparing its performance with several WMN methods.

  17. MEG-based imaging of focal neuronal current sources

    SciTech Connect

    Phillips, J.W.; Leahy, R.M.; Mosher, J.C.

    1996-07-01

    We describe a new approach to imaging neuronal current sources from measurements of the magnetoencephalogram (MEG) associated with sensory, motor, or cognitive brain activation. Previous approaches to this problem have concentrated on the use of weighted minimum norm inverse methods. While these methods ensure a unique solution, they do not introduce information specific to the MEG inverse problem, often producing overly smoothed solutions and exhibiting severe sensitivity to noise. We describe a Bayesian formulation of the inverse problem in which a Gibbs prior is constructed to reflect the sparse focal nature of neuronal current sources associated with evoked response data. The prior involves a binary process indicating active sources and a continuous Gaussian process designating associated amplitudes. An estimate of the primary current source distribution for a specific data set is formed by maximizing over the posterior probability with respect to the binary and continuous variables.

  18. Improved interframe registration based nonuniformity correction for focal plane arrays

    NASA Astrophysics Data System (ADS)

    Zuo, Chao; Chen, Qian; Gu, Guohua; Sui, Xiubao; Ren, Jianle

    2012-07-01

    In this paper, an improved interframe registration based nonuniformity correction algorithm for focal plane arrays is proposed. The method simultaneously estimates detector parameters and carries out the nonuniformity correction by minimizing the mean square error between the two properly registered image frames. A new masked phase correlation algorithm is introduced to obtain reliable shift estimates in the presence of fixed pattern noise. The use of an outliers exclusion scheme, together with a variable step size strategy, could not only promote the correction precision considerably, but also eliminate ghosting artifacts effectively. The performance of the proposed algorithm is evaluated with clean infrared image sequences with simulated nonuniformity and real pattern noise. We also apply the method to a real-time imaging system to show how effective it is in reducing noise and the ghosting artifacts.

  19. Femtosecond spatial pulse shaping at the focal plane.

    PubMed

    Martínez-Matos, Ó; Vaveliuk, P; Izquierdo, J G; Loriot, V

    2013-10-21

    Spatial shaping of ultrashort laser beams at the focal plane is theoretically analyzed. The description of the pulse is performed by its expansion in terms of Laguerre-Gaussian orthonormal modes. This procedure gives both a comprehensive interpretation of the propagation dynamics and the required signal to encode onto a spatial light modulator for spatial shaping, without using iterative algorithms. As an example, pulses with top-hat and annular spatial profiles are designed and their dynamics analyzed. The interference of top-hat pulses is also investigated finding potential applications in high precision pump-probe experiments (without using delay lines) and for the creation of subwavelength ablation patterns. In addition, a novel class of ultrashort pulses possessing non-stationary orbital angular momentum is also proposed. These exotic pulses provide additional degrees of freedom that open up new perspectives in fields such as laser-matter interaction and micro-machining. PMID:24150344

  20. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications

    PubMed Central

    Simard, J Marc; Kent, Thomas A; Chen, Mingkui; Tarasov, Kirill V; Gerzanich, Volodymyr

    2009-01-01

    Focal cerebral ischaemia and post-ischaemic reperfusion cause cerebral capillary dysfunction, resulting in oedema formation and haemorrhagic conversion. There are substantial gaps in understanding the pathophysiology, especially regarding early molecular participants. Here, we review physiological and molecular mechanisms involved. We reaffirm the central role of Starling's principle, which states that oedema formation is determined by the driving force and the capillary “permeability pore”. We emphasise that the movement of fluids is largely driven without new expenditure of energy by the ischaemic brain. We organise the progressive changes in osmotic and hydrostatic conductivity of abnormal capillaries into three phases: formation of ionic oedema, formation of vasogenic oedema, and catastrophic failure with haemorrhagic conversion. We suggest a new theory suggesting that ischaemia-induced capillary dysfunction can be attributed to de novo synthesis of a specific ensemble of proteins that determine osmotic and hydraulic conductivity in Starling's equation, and whose expression is driven by a distinct transcriptional program. PMID:17303532

  1. Nanotopographical modification: a regulator of cellular function through focal adhesions

    PubMed Central

    Biggs, Manus Jonathan Paul; Richards, R. Geoff; Dalby, Matthew J.

    2010-01-01

    As materials technology and the field of biomedical engineering advances, the role of cellular mechanisms, in particular adhesive interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device design has evolved from the exquisite ability of biological systems to respond to topographical features or chemical stimuli, a process that has led to the development of next-generation biomaterials for a wide variety of clinical disorders. In vitro studies have identified nanoscale features as potent modulators of cellular behavior through the onset of focal adhesion formation. The focus of this review is on the recent developments concerning the role of nanoscale structures on integrin-mediated adhesion and cellular function with an emphasis on the generation of medical constructs with regenerative applications. PMID:20138244

  2. Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells

    PubMed Central

    Kuo, Jean-Cheng

    2013-01-01

    Focal adhesions (FAs) are complex plasma membrane-associated macromolecular assemblies that serve to physically connect the actin cytoskeleton to integrins that engage with the surrounding extracellular matrix (ECM). FAs undergo maturation wherein they grow and change composition differentially to provide traction and to transduce the signals that drive cell migration, which is crucial to various biological processes, including development, wound healing and cancer metastasis. FA-related signalling networks dynamically modulate the strength of the linkage between integrin and actin and control the organization of the actin cytoskeleton. In this review, we have summarized a number of recent investigations exploring how FA composition is affected by the mechanical forces that transduce signalling networks to modulate cellular function and drive cell migration. Understanding the fundamental mechanisms of how force governs adhesion signalling provides insights that will allow the manipulation of cell migration and help to control migration-related human diseases. PMID:23551528

  3. Strained layer superlattice focal plane array having a planar structure

    DOEpatents

    Kim, Jin K; Carroll, Malcolm S; Gin, Aaron; Marsh, Phillip F; Young, Erik W; Cich, Michael J

    2012-10-23

    An infrared focal plane array (FPA) is disclosed which utilizes a strained-layer superlattice (SLS) formed of alternating layers of InAs and In.sub.xGa.sub.1-xSb with 0.ltoreq.x.ltoreq.0.5 epitaxially grown on a GaSb substrate. The FPA avoids the use of a mesa structure to isolate each photodetector element and instead uses impurity-doped regions formed in or about each photodetector for electrical isolation. This results in a substantially-planar structure in which the SLS is unbroken across the entire width of a 2-D array of the photodetector elements which are capped with an epitaxially-grown passivation layer to reduce or eliminate surface recombination. The FPA has applications for use in the wavelength range of 3-25 .mu.m.

  4. Elasticity of smectic liquid crystals with focal conic domains

    NASA Astrophysics Data System (ADS)

    Fujii, S.; Komura, S.; Ishii, Y.; Lu, C.-Y. D.

    2011-06-01

    We study the elastic properties of thermotropic smectic liquid crystals with focal conic domains (FCDs). After the application of the controlled preshear at different temperatures, we independently measure the shear modulus G' and the FCD size L. We find out that these quantities are related by the scaling relation G'≈γeff/L, where γeff is the effective surface tension of the FCDs. The experimentally obtained value of γeff shows the same scaling as the effective surface tension of the layered systems \\sqrt {KB} , where K and B are the bending modulus and the layer compression modulus, respectively. The similarity of this scaling relation to that of the surfactant onion phase suggests an universal rheological behavior of the layered systems with defects.

  5. New players in the pathogenesis of focal segmental glomerulosclerosis.

    PubMed

    Schell, Christoph; Huber, Tobias B

    2012-09-01

    Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular disorder causing end-stage renal disease. Since the first description of this clinicopathological entity in the early 1930s, various studies have identified numerous underlying pathogenetic mechanisms. Nevertheless, FSGS is still a complex, only partially understood and in its classification sometimes confusing disease. A unifying pathophysiological concept has not been identified and might not even exist. However, research efforts of past decades identified FSGS as a podocytopathy with several podocyte molecules being key players in the development and the course of FSGS. Podocytes are crucially involved in the formation of the glomerular barrier and any assault on their delicate physiological balance and architecture can result in the development of proteinuria. The following review article will introduce most recent examples identifying novel players in the complex pathogenesis of FSGS. PMID:22767631

  6. Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis

    PubMed Central

    Kim, Jae Seok; Han, Byoung Geun; Choi, Seung Ok; Cha, Seung-Kuy

    2016-01-01

    Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic syndrome leading to end stage renal disease (ESRD). There are two types of FSGS, primary (idiopathic) and secondary forms. Secondary FSGS shows less severe clinical features compared to those of the primary one. However, secondary FSGS has an important clinical significance because a variety of renal diseases progress to ESRD thorough the form of secondary FSGS. The defining feature of FSGS is proteinuria. The key event of FSGS is podocyte injury which is caused by multiple factors. Unanswered questions about how these factors act on podocytes to cause secondary FSGS are various and ill-defined. In this review, we provide brief overview and new insights into FSGS, podocyte injury, and their potential linkage suggesting clues to answer for treatment of the disease. PMID:27088082

  7. Integration of IR focal plane arrays with massively parallel processor

    NASA Astrophysics Data System (ADS)

    Esfandiari, P.; Koskey, P.; Vaccaro, K.; Buchwald, W.; Clark, F.; Krejca, B.; Rekeczky, C.; Zarandy, A.

    2008-04-01

    The intent of this investigation is to replace the low fill factor visible sensor of a Cellular Neural Network (CNN) processor with an InGaAs Focal Plane Array (FPA) using both bump bonding and epitaxial layer transfer techniques for use in the Ballistic Missile Defense System (BMDS) interceptor seekers. The goal is to fabricate a massively parallel digital processor with a local as well as a global interconnect architecture. Currently, this unique CNN processor is capable of processing a target scene in excess of 10,000 frames per second with its visible sensor. What makes the CNN processor so unique is that each processing element includes memory, local data storage, local and global communication devices and a visible sensor supported by a programmable analog or digital computer program.

  8. Panoramic monocentric imaging using fiber-coupled focal planes.

    PubMed

    Stamenov, Igor; Arianpour, Ashkan; Olivas, Stephen J; Agurok, Ilya P; Johnson, Adam R; Stack, Ronald A; Morrison, Rick L; Ford, Joseph E

    2014-12-29

    Monocentric lenses provide high-resolution wide field of view imaging onto a hemispherical image surface, which can be coupled to conventional focal planes using fiber-bundle image transfer. We show the design and characterization of a 2-glass concentric F/1.0 lens, and describe integration of 5 Mpixel 1.75µm pitch back-side illuminated color CMOS sensors with 2.5µm pitch fiber bundles, then show the fiber-coupled lens compares favorably in both resolution and light collection to a 10x larger conventional F/4 wide angle photographic lens. We describe assembly of the monocentric lens and 6 adjacent sensors with focus optomechanics into an extremely compact 30Mpixel panoramic imager with a 126° "letterbox" format field of view. PMID:25607140

  9. Direct simulation Monte Carlo method with a focal mechanism algorithm

    NASA Astrophysics Data System (ADS)

    Rachman, Asep Nur; Chung, Tae Woong; Yoshimoto, Kazuo; Yun, Sukyoung

    2015-01-01

    To simulate the observation of the radiation pattern of an earthquake, the direct simulation Monte Carlo (DSMC) method is modified by implanting a focal mechanism algorithm. We compare the results of the modified DSMC method (DSMC-2) with those of the original DSMC method (DSMC-1). DSMC-2 shows more or similarly reliable results compared to those of DSMC-1, for events with 12 or more recorded stations, by weighting twice for hypocentral distance of less than 80 km. Not only the number of stations, but also other factors such as rough topography, magnitude of event, and the analysis method influence the reliability of DSMC-2. The most reliable result by DSMC-2 is obtained by the best azimuthal coverage by the largest number of stations. The DSMC-2 method requires shorter time steps and a larger number of particles than those of DSMC-1 to capture a sufficient number of arrived particles in the small-sized receiver.

  10. Infrared focal plane detector modules for space applications at AIM

    NASA Astrophysics Data System (ADS)

    Hübner, Dominique; Hanna, Stefan; Thöt, Richard; Gassmann, Kai-Uwe; Haiml, Markus; Weber, Andreas; Haas, Luis-Dieter; Ziegler, Johann; Nothaft, Hans-Peter; Fick, W.

    2012-09-01

    In the framework of this paper, AIM presents the actual status of some of its currently ongoing focal plane detector module developments for space applications covering the spectral range from the short-wavelength infrared (SWIR) to the long-wavelength infrared (LWIR) and very-long-wavelength infrared (VLWIR), where both imaging and spectroscopy applications will be addressed. In particular, the integrated detector cooler assemblies for a mid-wavelength infrared (MWIR) push-broom imaging satellite mission, for the German hyperspectral satellite mission EnMAP will be elaborated. Additionally dedicated detector modules for LWIR/VLWIR sounding, providing the possibility to have two different PVs driven by one ROIC will be addressed.

  11. ACIS Focal Plane Temperature Control and Observational Strategies

    NASA Astrophysics Data System (ADS)

    Adams-Wolk, Nancy; Plucinsky, P. P.; Aldcroft, T. L.; Germain, G.

    2012-01-01

    The Chandra X-Ray Observatory continues to deliver excellent science to the astronomical community as it enters its 13th observation cycle. The thermal conditions of the spacecraft components have changed over time necessitating changes in observing strategies; particularly for the ACIS Instrument. In this poster, we focus on the thermal conditions that affect the ACIS focal plane temperature, and the ACIS observational parameters that need to be carefully considered for the observer. We discuss the electronics affected, the specific conditions that can effect the science return and how Guest Observers can choose observational parameters to mitigate these issues.The Guest Observers must be aware of changes and considerations needed when preparing their observations to continue the high quality of science return from Chandra.

  12. Focal segmental glomerulosclerosis and chronic kidney disease in pediatric patients.

    PubMed

    Kiffel, Jeremy; Rahimzada, Yael; Trachtman, Howard

    2011-09-01

    Focal segmental glomerulosclerosis (FSGS) is one of the most common forms of acquired glomerular disease leading to end-stage kidney disease. Its incidence is rising around the world. There is no proven therapy for those patients who do not respond to corticosteroids and it can recur in 20% to 25% of patients who receive a kidney transplant. The disease can be primary, or it can be secondary to various conditions including vesicoureteral reflux, obesity, medications, and infections. Recent advances have demonstrated the important role of genetic mutations in podocyte proteins as a cause of FSGS. There is an urgent need for randomized clinical trials to develop safe and effective therapy for FSGS that occurs in the native or transplanted kidney. PMID:21896374

  13. FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND CHRONIC KIDNEY DISASE IN PEDIATRIC PATIENTS

    PubMed Central

    Kiffel, Jeremy; Rahimzada, Yael; Trachtman, Howard

    2011-01-01

    Focal segmental glomerulosclerosis (FSGS) is one of the most common forms of acquired glomerular disease leading to end stage kidney disease (ESKD). Its incidence is rising around the world. There is no proven therapy for those patients who do not respond to corticosteroids and it can recur in 20–25% of patients who receive a kidney transplant. The disease can be primary or secondary to various conditions including vesicoureteral reflux, obesity, medications, and infections. Recent advances have demonstrated the important role of genetic mutations in podocyte proteins as a cause of FSGS. There is an urgent need for randomized clinical trials to develop safe and effective therapy for FSGS that occurs in the native or transplanted kidney. PMID:21896374

  14. Blocked impurity band hybrid infrared focal plane arrays for astronomy

    NASA Technical Reports Server (NTRS)

    Reynolds, D. B.; Seib, D. H.; Stetson, S. B.; Herter, T.; Rowlands, N.

    1989-01-01

    High-performance infrared hybrid focal plane arrays using 10- x 50-element Si:As blocked-impurity-band (BIB) detectors (cutoff wavelength = 28 microns) and matching switched MOSFET multiplexers have been developed and characterized for space astronomy. Use of impurity-band-conduction technology provides detectors which are nuclear-radiation-hard and free of the many anomalies associated with conventional silicon photoconductive detectors. Emphasis in the present work is on recent advances in detector material quality which have led to significantly improved detector and hybrid characteristics. Results demonstrating increased quantum efficiency (particularly at short-wavelength infrared), obtained by varying the BIB detector properties (infrared active layer thickness and arsenic doping profile), are summarized. Measured read noise and dark current for different temperatures are reported. The hybrid array performance achieved demonstrates that BIB detectors are well suited for use in astronomical instrumentation.

  15. Selective ROCK2 inhibition in focal cerebral ischemia

    PubMed Central

    Hyun Lee, Jeong; Zheng, Yi; von Bornstadt, Daniel; Wei, Ying; Balcioglu, Aygul; Daneshmand, Ali; Yalcin, Nilufer; Yu, Esther; Herisson, Fanny; Atalay, Yahya B; Kim, Maya H; Ahn, Yong-Joo; Balkaya, Mustafa; Sweetnam, Paul; Schueller, Olivier; Poyurovsky, Masha V; Kim, Hyung-Hwan; Lo, Eng H; Furie, Karen L; Ayata, Cenk

    2014-01-01

    Objective Rho-associated kinase (ROCK) is a key regulator of numerous processes in multiple cell types relevant in stroke pathophysiology. ROCK inhibitors have improved outcome in experimental models of acute ischemic or hemorrhagic stroke. However, the relevant ROCK isoform (ROCK1 or ROCK2) in acute stroke is not known. Methods We characterized the pharmacodynamic and pharmacokinetic profile, and tested the efficacy and safety of a novel selective ROCK2 inhibitor KD025 (formerly SLx-2119) in focal cerebral ischemia models in mice. Results KD025 dose-dependently reduced infarct volume after transient middle cerebral artery occlusion. The therapeutic window was at least 3 h from stroke onset, and the efficacy was sustained for at least 4 weeks. KD025 was at least as efficacious in aged, diabetic or female mice, as in normal adult males. Concurrent treatment with atorvastatin was safe, but not additive or synergistic. KD025 was also safe in a permanent ischemia model, albeit with diminished efficacy. As one mechanism of protection, KD025 improved cortical perfusion in a distal middle cerebral artery occlusion model, implicating enhanced collateral flow. Unlike isoform-nonselective ROCK inhibitors, KD025 did not cause significant hypotension, a dose-limiting side effect in acute ischemic stroke. Interpretation Altogether, these data show that KD025 is efficacious and safe in acute focal cerebral ischemia in mice, implicating ROCK2 as the relevant isoform in acute ischemic stroke. Data suggest that selective ROCK2 inhibition has a favorable safety profile to facilitate clinical translation. PMID:24466563

  16. Glomerular Aging and Focal Global Glomerulosclerosis: A Podometric Perspective.

    PubMed

    Hodgin, Jeffrey B; Bitzer, Markus; Wickman, Larysa; Afshinnia, Farsad; Wang, Su Q; O'Connor, Christopher; Yang, Yan; Meadowbrooke, Chrysta; Chowdhury, Mahboob; Kikuchi, Masao; Wiggins, Jocelyn E; Wiggins, Roger C

    2015-12-01

    Kidney aging is associated with an increasing proportion of globally scarred glomeruli, decreasing renal function, and exponentially increasing ESRD prevalence. In model systems, podocyte depletion causes glomerulosclerosis, suggesting age-associated glomerulosclerosis could be caused by a similar mechanism. We measured podocyte number, size, density, and glomerular volume in 89 normal kidney samples from living and deceased kidney donors and normal poles of nephrectomies. Podocyte nuclear density decreased with age due to a combination of decreased podocyte number per glomerulus and increased glomerular volume. Compensatory podocyte cell hypertrophy prevented a change in the proportion of tuft volume occupied by podocytes. Young kidneys had high podocyte reserve (podocyte density >300 per 10(6) µm(3)), but by 70-80 years of age, average podocyte nuclear density decreased to, <100 per 10(6) µm(3), with corresponding podocyte hypertrophy. In older age podocyte detachment rate (urine podocin mRNA-to-creatinine ratio) was higher than at younger ages and podocytes were stressed (increased urine podocin-to-nephrin mRNA ratio). Moreover, in older kidneys, proteinaceous material accumulated in the Bowman space of glomeruli with low podocyte density. In a subset of these glomeruli, mass podocyte detachment events occurred in association with podocytes becoming binucleate (mitotic podocyte catastrophe) and subsequent wrinkling of glomerular capillaries, tuft collapse, and periglomerular fibrosis. In kidneys of young patients with underlying glomerular diseases similar pathologic events were identified in association with focal global glomerulosclerosis. Podocyte density reduction with age may therefore directly lead to focal global glomerulosclerosis, and all progressive glomerular diseases can be considered superimposed accelerators of this underlying process. PMID:26038526

  17. Requirement of focal adhesion kinase in branching tubulogenesis.

    PubMed

    Wei, Wei-Chun; Kopec, Anna K; Tang, Ming-Jer

    2009-01-01

    We previously demonstrated that alpha3beta1 integrins are essential to hepatocyte growth factor (HGF)-independent branching tubulogenesis in Mardin-Darby Canine Kidney (MDCK) cells. However, the involvement of integrin downstream signaling molecules remains unclear. In the present study, we successfully isolated cell lines possessing different tubulogenic potentials from the MDCK cells; cyst clones (CA4, CA6) forming cystic structures when cultured in 0.3% type I collagen gel and mass clones (M610, M611, M612) forming aggregated masses. Cyst clones maintained cystic structure in 0.1% collagen gel, whereas mass clones spontaneously developed into tubules. Both clones exhibited various morphologies when cultured on a dish: cyst clones formed aggregated islands, while mass clones were more scattered and exhibited higher migration capacity. Among several focal adhesion machinery proteins examined, only the expression and phosphorylation level of focal adhesion kinase (FAK) in mass clones was higher than in cyst clones, while other proteins showed no obvious differences. However, overexpression of wild type FAK in CA6 cells did not facilitate branching tubule formation in 0.1% collagen gel. Targeted decrease in the expression level of FAK in M610 cells with the application of antisense cDNA resulted in a marked reduction of branching tubule formation in 0.1% collagen gel and showed a down-regulation of fibronectin assembly, which is known to promote tubulogenesis. In contrast, overexpression of wild type FAK in CA6 cells had no effect on fibronectin assembly. Taken together, our data demonstrates that FAK is required, but not sufficient for HGF-independent branching tubulogenesis in MDCK cells. PMID:19272169

  18. Delayed Postconditioning Protects against Focal Ischemic Brain Injury in Rats

    PubMed Central

    Ren, Chuancheng; Gao, Xuwen; Niu, Gang; Yan, Zhimin; Chen, Xiaoyuan; Zhao, Heng

    2008-01-01

    Background We and others have reported that rapid ischemic postconditioning, interrupting early reperfusion after stroke, reduces infarction in rats. However, its extremely short therapeutic time windows, from a few seconds to minutes after reperfusion, may hinder its clinical translation. Thus, in this study we explored if delayed postconditioning, which is conducted a few hours after reperfusion, offers protection against stroke. Methods and Results Focal ischemia was generated by 30 min occlusion of bilateral common carotid artery (CCA) combined with permanent occlusion of middle cerebral artery (MCA); delayed postconditioning was performed by repetitive, brief occlusion and release of the bilateral CCAs, or of the ipsilateral CCA alone. As a result, delayed postconditioning performed at 3h and 6h after stroke robustly reduced infarct size, with the strongest protection achieved by delayed postconditioning with 6 cycles of 15 min occlusion/15 min release of the ipsilateral CCA executed from 6h. We found that this delayed postconditioning provided long-term protection for up to two months by reducing infarction and improving outcomes of the behavioral tests; it also attenuated reduction in 2-[18F]-fluoro-2-deoxy-D-glucose (FDG)-uptake therefore improving metabolism, and reduced edema and blood brain barrier leakage. Reperfusion in ischemic stroke patients is usually achieved by tissue plasminogen activator (tPA) application, however, t-PA's side effect may worsen ischemic injury. Thus, we tested whether delayed postconditioning counteracts the exacerbating effect of t-PA. The results showed that delayed postconditioning mitigated the worsening effect of t-PA on infarction. Conclusion Delayed postconditioning reduced ischemic injury after focal ischemia, which opens a new research avenue for stroke therapy and its underlying protective mechanisms. PMID:19066627

  19. Guanosine Protects Against Cortical Focal Ischemia. Involvement of Inflammatory Response.

    PubMed

    Hansel, Gisele; Tonon, André Comiran; Guella, Felipe Lhywinskh; Pettenuzzo, Letícia Ferreira; Duarte, Thiago; Duarte, Marta Maria Medeiros Frescura; Oses, Jean Pierre; Achaval, Matilde; Souza, Diogo Onofre

    2015-12-01

    Stroke is the major cause of death and the most frequent cause of disability in the adult population worldwide. Guanosine plays an important neuroprotective role in several cerebral ischemic models and is involved in the modulation of oxidative responses and glutamatergic parameters. Because the excessive reactive oxygen species produced during an ischemic event can trigger an inflammatory response, the purpose of this study was to evaluate the hypothesis that guanosine is neuroprotective against focal cerebral ischemia, inhibits microglia/macrophages activation, and mediates an inflammatory response ameliorating the neural damage. Permanent focal cerebral ischemia was induced in adult rats, and guanosine was administered immediately, 1, 3, and 6 h after surgery. Twenty-four hours after ischemia, the asymmetry scores were evaluated by the cylinder test; neuronal damage was evaluated by Fluoro-Jade C (FJC) staining and propidium iodide (PI) incorporation; microglia and immune cells were evaluated by anti-Iba-1 antibody; and inflammatory parameters such as interleukins (IL): IL-1, IL-6, IL-10; tumor necrosis factors alpha (TNF-α); and interferon-gamma (INF-γ) were evaluated in the brain tissue and cerebrospinal fluid. The ischemic event increased the levels of Iba-1-positive cells and pro-inflammatory cytokines and decreased IL-10 levels (an anti-inflammatory cytokine) in the lesion periphery. The guanosine treatment attenuated the changes in these inflammatory parameters and also reduced the infarct volume, PI incorporation, and number of FJC-positive cells, improving the functional recovery. Thus, guanosine may have been a promising therapeutic agent for the treatment of ischemic brain injury by reduction of inflammatory process triggered in an ischemic event. PMID:25394382

  20. Crystal Structure of the FERM Domain of Focal Adhesion Kinase

    SciTech Connect

    Ceccarelli,D.; Song, H.; Poy, F.; Schaller, M.; Eck, M.

    2006-01-01

    Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that localizes to focal adhesions in adherent cells. Through phosphorylation of proteins assembled at the cytoplasmic tails of integrins, FAK promotes signaling events that modulate cellular growth, survival, and migration. The amino-terminal region of FAK contains a region of sequence homology with band 4.1 and ezrin/radixin/moesin (ERM) proteins termed a FERM domain. FERM domains are found in a variety of signaling and cytoskeletal proteins and are thought to mediate intermolecular interactions with partner proteins and phospholipids at the plasma membrane and intramolecular regulatory interactions. Here we report two crystal structures of an NH2-terminal fragment of avian FAK containing the FERM domain and a portion of the regulatory linker that connects the FERM and kinase domains. The tertiary folds of the three subdomains (F1, F2, and F3) are similar to those of known FERM structures despite low sequence conservation. Differences in the sequence and relative orientation of the F3 subdomain alters the nature of the interdomain interface, and the phosphoinositide binding site found in ERM family FERM domains is not present in FAK. A putative protein interaction site on the F3 lobe is masked by the proximal region of the linker. Additionally, in one structure the adjacent Src SH3 and SH2 binding sites in the linker associate with the surfaces of the F3 and F1 lobes, respectively. These structural features suggest the possibility that protein interactions of the FAK FERM domain can be regulated by binding of Src kinases to the linker segment.

  1. Design Aspects of Focal Beams From High-Intensity Arrays

    PubMed Central

    Stephens, Douglas N.; Kruse, Dustin E.; Qin, Shengping; Ferrara, Katherine W.

    2011-01-01

    As the applications of ultrasonic thermal therapies expand, the design of the high-intensity array must address both the energy delivery of the main beam and the character and relevance of off-target beam energy. We simulate the acoustic field performance of a selected set of circular arrays organized by array format, including flat versus curved arrays, periodic versus random arrays, and center void diameter variations. Performance metrics are based on the −3-dB focal main lobe (FML) positioning range, axial grating lobe (AGL) temperatures, and side lobe levels. Using finite-element analysis, we evaluate the relative heating of the FML and the AGLs. All arrays have a maximum diameter of 100λ, with element count ranging from 64 to 1024 and continuous wave frequency of 1.5 MHz. First, we show that a 50% spherical annulus produces focus beam side lobes which decay as a function of lateral distance at nearly 87% of the exponential rate of a full aperture. Second, for the arrays studied, the efficiency of power delivery over the −3-dB focus positioning range for spherical arrays is at least 2-fold greater than for flat arrays; the 256-element case shows a 5-fold advantage for the spherical array. Third, AGL heating can be significant as the focal target is moved to its distal half-intensity depth from the natural focus. Increasing the element count of a randomized array to 256 elements decreases the AGL-to-FML heating ratio to 0.12 at the distal half-intensity depth. Further increases in element count yield modest improvements. A 49% improvement in the AGL-to-peak heating ratio is predicted by using the Sumanaweera spiral element pattern with randomization. PMID:21859578

  2. Design of the Focal Plane for the Pleiades HR Instrument

    NASA Astrophysics Data System (ADS)

    Plaisant, Gérard; Le Goff, Roland; Deswarte, David

    This paper presents the design of the focal plane of the future French observation satellite PLEIADES. The purpose of this focal plane is to analyse images in panchromatic (Pa) as far as multi- spectral (Xs) bands in push-broom mode. The size of the observed image is close to 400 mm and it shall be analysed in 30.000 samples in Pa and 7.500 in Xs, resulting in an on- ground resolution lower than 1 meter in Pa. Compared to the previous French SPOT instrument series, the optical architecture is largely simplified : the Xs images are separated in the field of view and detected by four parallel CCD lines integrated in the same package. The spectral selection is made by means of strip filters placed very close in front of the Xs detector. Pa and Xs images are shifted in the field of view. Folding mirrors are used to cope with both constraints : the CCD package size and the required limitation of the distance Pa-Xs. The detection in Pa is made thanks to a Time Delay Integration (TDI) CCD in order to improve the radiometric performances. Five TDI CCD providing each 6000 pixels are optically butted to form a continuous line. The thermo-mechanical concept makes use of the characteristics of the SiC structure. It allows to evacuate the CCDs and their close electronics power towards a radiator while maintaining stable the detection lines geometry. The development is presently in phase B ; the phase C/D will start in 2002.

  3. Postseismic seafloor movements above the focal region of the 2011 Tohoku-oki earthquake

    NASA Astrophysics Data System (ADS)

    Sato, M.; Watanabe, S.; Yokota, Y.; Ujihara, N.; Ishikawa, T.; Fujita, M.; Mochizuki, M.; Asada, A.

    2013-12-01

    We have been developing a precise seafloor positioning system using the GPS/acoustic combination technique and carrying out campaign observations along the major trenches on the Pacific side of Japan, such as the Japan Trench and the Nankai Trough. From the past observations over a decade, we have successfully obtained intraplate movements and coseismic movements. In this course, the 2011 Tohoku-oki earthquake (M9.0) occurred on the plate boundary off northeastern Japan on March 11, 2011. The focal region inferred from the distribution of aftershocks stretches about 500 km long and 200 km wide in the sea area on the Pacific side of northeastern Japan. We have six seafloor reference points above the focal region. Although we already reported coseismic displacements detected at those sites, we have still continued campaign observations and have detected postseismic movements of the earthquake. In the horizontal components, coseismic displacements showed toward ESE at all the sites but the amounts are different by sea area. In the northern part of the focal region, or around the epicenter, coseismic displacements of 15-24 m were detected. The area where the coseismic displacement was greater than 20 m stretched about at least 70 km from the epicenter and outside the area, the displacements decreased rapidly. In contrast, in the southern part, coseismic displacements were much smaller, less than 5 m. After the earthquake, characteristic movements by sea area can be seen. In the southern part, seafloor movements toward ESE have been observed and decaying logarithmically with time, which is the same direction as the coseismic displacements and similar to postseismic movements detected by on-land GPS. However, around the epicenter, seafloor movements are entirely different. In the area where large coseismic displacements were detected, linear trends toward WNW, in the opposite direction from coseismic displacements, are observed. The estimated rates are more than 10 cm

  4. Floating Point Control Library

    2007-08-02

    Floating Point Control is a Library that allows for the manipulation of floating point unit exception masking funtions control exceptions in both the Streaming "Single Instruction, Multiple Data" Extension 2 (SSE2) unit and the floating point unit simultaneously. FPC also provides macros to set floating point rounding and precision control.

  5. Quasi-iso-focal hole pattern formation by Checker-Board PSM (CB-PSM)

    NASA Astrophysics Data System (ADS)

    Nakao, S.; Maejima, S.; Minamide, A.; Saitoh, H.; Hanawa, T.; Suko, K.

    2008-03-01

    A novel RET, which enables on-grid sub-50 nm hole pattern formation with ArF immersion lithography, has been developed. One of the authors has found quasi-iso-focal point image generation at the center of square area of high transmission embedded attenuating phase shift mask (EA-PSM), where four small openings are laid out at the corners of the area, utilizing an optimized quadrupole illumination. As an extension of continuous configuration, checker-board like mask pattern arrangement is created. In the mask, small openings and opaque pads are arranged like as checkerboard, whose base pitch is around resolution limit of targeted optical system. The mask pattern arrangement is named as "Checker-Board PSM (CB-PSM)". By eliminating any one opening from "checker-board", very fine point image is generated at the place. Because four openings around the eliminated one are necessary for the fine imaging characteristic, minimum distance between the point images is about the double of that for resolution limit. After simulation study of imaging, experiments are carried out to prove the fine imaging performance utilizing ArF immersion optics with NA=1.07 and a tri-level resist system. As a result, sub-50nm isolated hole is successfully formed with DOF larger than 200 nm. Simultaneously, ~ 60 nm semi-dense hole with pitch of 240 nm is printed with over 200 nm DOF. Moreover, application of conventional mask pattern arrangement, ultimately dense hole of 140nm pitch is well formed. As a conclusion, we believe that CB-PSM is a promising candidate for hole pattern formation at 32 nm node and beyond.

  6. Computing the Casimir energy using the point-matching method

    SciTech Connect

    Lombardo, F. C.; Mazzitelli, F. D.; Vazquez, M.; Villar, P. I.

    2009-09-15

    We use a point-matching approach to numerically compute the Casimir interaction energy for a two perfect-conductor waveguide of arbitrary section. We present the method and describe the procedure used to obtain the numerical results. At first, our technique is tested for geometries with known solutions, such as concentric and eccentric cylinders. Then, we apply the point-matching technique to compute the Casimir interaction energy for new geometries such as concentric corrugated cylinders and cylinders inside conductors with focal lines.

  7. Optical Polarization Möbius Strips and Points of Purely Transverse Spin Density

    NASA Astrophysics Data System (ADS)

    Bauer, Thomas; Neugebauer, Martin; Leuchs, Gerd; Banzer, Peter

    2016-07-01

    Tightly focused light beams can exhibit complex and versatile structured electric field distributions. The local field may spin around any axis including a transverse axis perpendicular to the beams' propagation direction. At certain focal positions, the corresponding local polarization ellipse can even degenerate into a perfect circle, representing a point of circular polarization or C point. We consider the most fundamental case of a linearly polarized Gaussian beam, where—upon tight focusing—those C points created by transversely spinning fields can form the center of 3D optical polarization topologies when choosing the plane of observation appropriately. Because of the high symmetry of the focal field, these polarization topologies exhibit nontrivial structures similar to Möbius strips. We use a direct physical measure to find C points with an arbitrarily oriented spinning axis of the electric field and experimentally investigate the fully three-dimensional polarization topologies surrounding these C points by exploiting an amplitude and phase reconstruction technique.

  8. Correlation between Focal Nodular Low Signal Changes in Hoffa's Fat Pad Adjacent to Anterior Femoral Cartilage and Focal Cartilage Defect Underlying This Region and Its Possible Implication

    PubMed Central

    Ng, Wuey Min

    2016-01-01

    Purpose. This study investigates the association between focal nodular mass with low signal in Hoffa's fat pad adjacent to anterior femoral cartilage of the knee (FNMHF) and focal cartilage abnormality in this region. Method. The magnetic resonance fast imaging employing steady-state acquisition sequence (MR FIESTA) sagittal and axial images of the B1 and C1 region (described later) of 148 patients were independently evaluated by two reviewers and categorized into four categories: normal, FNMHF with underlying focal cartilage abnormality, FNMHF with normal cartilage, and cartilage abnormality with no FNMHF. Results. There was a significant association (p = 0.00) between FNMHF and immediate adjacent focal cartilage abnormality with high interobserver agreement. The absence of focal nodular lesions next to the anterior femoral cartilage has a very high negative predictive value for chondral injury (97.8%). Synovial biopsy of focal nodular lesion done during arthroscopy revealed some fibrocollagenous tissue and no inflammatory cells. Conclusion. We postulate that the FNMHF adjacent to the cartilage defects is a form of normal healing response to the cartilage damage. One patient with FHMHF and underlying cartilage abnormality was rescanned six months later. In this patient, the FNMHF disappeared and normal cartilage was observed in the adjacent region which may support this theory. PMID:27213085

  9. Synthesis of fully continuous phase screens for tailoring the focal plane irradiance profiles

    SciTech Connect

    Dixit, S.; Feit, M.

    1996-04-26

    We present an iterative procedure for constructing fully continuous phase screens for tailoring the focal plane intensity distributions. This algorithm alleviates the stagnations experienced in the application of the Gerchberg-Saxton algorithm with a random initial phase screen and leads to efficient distribution of the incident energy into the desired focal plane profile.

  10. Fast focal zooming scheme for direct drive fusion implemented by inserting KD2PO4 crystal

    NASA Astrophysics Data System (ADS)

    Zhong, Zheqiang; Hu, Xiaochuan; Zhang, Bin

    2016-06-01

    The highly required uniformity of target in direct-drive fusion is difficult to achieve and maintain during the entire laser fusion implosion. To mitigate the increasing nonuniformity, the fast focal zooming scheme implemented by inserting an electro-optic (EO) crystal in the front end of beamline has been proposed. Functioning as a phase plate, the specifically designed EO crystal may add the induced spherical wavefront to the laser beam and alter its focusing characteristics. However, in order to zoom out the focal spot by half, the required voltage for KD2PO4 (DKDP) with single pair of electrodes is relatively high. In order to decrease the voltage while maintaining the zooming performance, the DKDP cylinder with multi pairs of electrodes has been presented. The continuous phase plate (CPP) is designed according to both the injected beam and the output field. However, the conventional CPP is designed based on the assumption of an injected beam without wavefront distortion, which would zoom in the focal spot variation in the focal zooming scheme. In order to zoom out the focal spot, a redesigned CPP has been proposed by adding a spherical wavefront to the phase variation of the conventional CPP and further optimizing. On the basis, the focusing characteristics of laser beam during the fast focal zooming process have been analyzed. Results indicate that the focal spot size decreases with the increasing voltage on DKDP crystal, meanwhile the uniformity maintains high during the focal zooming process.

  11. Focal Adhesion of Osteoblastic Cells on Titanium Surface with Amine Functionalities Formed by Plasma Polymerization

    NASA Astrophysics Data System (ADS)

    Song, Heesang; Jung, Sang Chul; Kim, Byung Hoon

    2012-08-01

    To enhance the focal adhesion of osteoblastic cells on a titanium surface, plasma polymerized allyl amine (AAm) thin films were deposited by plasma polymerization. This plasma polymer functionalization of titanium is advantageous for osteoblastic focal adhesion formation. Such Ti surfaces are useful for the fabrication of titanium-based dental implants for enhancement of osseointegration.

  12. Distributions of Irritative Zones Are Related to Individual Alterations of Resting-State Networks in Focal Epilepsy

    PubMed Central

    Song, Yinchen; Sanganahalli, Basavaraju G.; Hyder, Fahmeed; Lin, Wei-Chiang; Riera, Jorge J.

    2015-01-01

    Alterations in the connectivity patterns of the fMRI-based resting-state networks (RSNs) have been reported in several types of epilepsies. Evidence pointed out these alterations might be associated with the genesis and propagation of interictal epileptiform discharges (IEDs). IEDs also evoke blood-oxygen-level dependent (BOLD) responses, which have been used to delineate irritative zones during preoperative work-up. Therefore, one may expect a relationship between the topology of the IED-evoked BOLD response network and the altered spatial patterns of the RSNs. In this study, we used EEG recordings and fMRI data obtained simultaneously from a chronic model of focal epilepsy in Wistar rats to verify our hypothesis. We found that IED-evoked BOLD response networks comprise both cortical and subcortical structures with a rat-dependent topology. In all rats, IEDs evoke both activation and deactivation types of BOLD responses. Using a Granger causality method, we found that in many cases areas with BOLD deactivation have directed influences on areas with activation (p<0.05). We were able to predict topological properties (i.e., focal/diffused, unilateral/bilateral) of the IED-evoked BOLD response network by performing hierarchical clustering analysis on major spatial features of the RSNs. All these results suggest that IEDs and disruptions in the RSNs found previously in humans may be different manifestations of the same transient events, probably reflecting altered consciousness. In our opinion, the shutdown of specific nodes of the default mode network may cause uncontrollable excitability in other functionally connected brain areas. We conclude that IED-evoked BOLD responses (i.e., activation and deactivation) and alterations of RSNs are intrinsically related, and speculate that an understanding of their interplay is necessary to discriminate focal epileptogenesis and network propagation phenomena across different brain modules via hub-based connectivity. PMID

  13. Probing mechanical principles of focal contacts in cell–matrix adhesion with a coupled stochastic–elastic modelling framework

    PubMed Central

    Gao, Huajian; Qian, Jin; Chen, Bin

    2011-01-01

    Cell–matrix adhesion depends on the collective behaviours of clusters of receptor–ligand bonds called focal contacts between cell and extracellular matrix. While the behaviour of a single molecular bond is governed by statistical mechanics at the molecular scale, continuum mechanics should be valid at a larger scale. This paper presents an overview of a series of recent theoretical studies aimed at probing the basic mechanical principles of focal contacts in cell–matrix adhesion via stochastic–elastic models in which stochastic descriptions of molecular bonds and elastic descriptions of interfacial traction–separation are unified in a single modelling framework. The intention here is to illustrate these principles using simple analytical and numerical models. The aim of the discussions is to provide possible clues to the following questions: why does the size of focal adhesions (FAs) fall into a narrow range around the micrometre scale? How can cells sense and respond to substrates of varied stiffness via FAs? How do the magnitude and orientation of mechanical forces affect the binding dynamics of FAs? The effects of cluster size, cell–matrix elastic modulus, loading direction and cytoskeletal pretension on the lifetime of FA clusters have been investigated by theoretical arguments as well as Monte Carlo numerical simulations, with results showing that intermediate adhesion size, stiff substrate, cytoskeleton stiffening, low-angle pulling and moderate cytoskeletal pretension are factors that contribute to stable FAs. From a mechanistic point of view, these results provide possible explanations for a wide range of experimental observations and suggest multiple mechanisms by which cells can actively control adhesion and de-adhesion via cytoskeletal contractile machinery in response to mechanical properties of their surroundings. PMID:21632610

  14. Distributions of Irritative Zones Are Related to Individual Alterations of Resting-State Networks in Focal Epilepsy.

    PubMed

    Song, Yinchen; Sanganahalli, Basavaraju G; Hyder, Fahmeed; Lin, Wei-Chiang; Riera, Jorge J

    2015-01-01

    Alterations in the connectivity patterns of the fMRI-based resting-state networks (RSNs) have been reported in several types of epilepsies. Evidence pointed out these alterations might be associated with the genesis and propagation of interictal epileptiform discharges (IEDs). IEDs also evoke blood-oxygen-level dependent (BOLD) responses, which have been used to delineate irritative zones during preoperative work-up. Therefore, one may expect a relationship between the topology of the IED-evoked BOLD response network and the altered spatial patterns of the RSNs. In this study, we used EEG recordings and fMRI data obtained simultaneously from a chronic model of focal epilepsy in Wistar rats to verify our hypothesis. We found that IED-evoked BOLD response networks comprise both cortical and subcortical structures with a rat-dependent topology. In all rats, IEDs evoke both activation and deactivation types of BOLD responses. Using a Granger causality method, we found that in many cases areas with BOLD deactivation have directed influences on areas with activation (p<0.05). We were able to predict topological properties (i.e., focal/diffused, unilateral/bilateral) of the IED-evoked BOLD response network by performing hierarchical clustering analysis on major spatial features of the RSNs. All these results suggest that IEDs and disruptions in the RSNs found previously in humans may be different manifestations of the same transient events, probably reflecting altered consciousness. In our opinion, the shutdown of specific nodes of the default mode network may cause uncontrollable excitability in other functionally connected brain areas. We conclude that IED-evoked BOLD responses (i.e., activation and deactivation) and alterations of RSNs are intrinsically related, and speculate that an understanding of their interplay is necessary to discriminate focal epileptogenesis and network propagation phenomena across different brain modules via hub-based connectivity. PMID

  15. Self-aggregation of amphiphilic [60]fullerenyl focal point functionalized PAMAM dendrons into pseudodendrimers: DNA binding involving dendriplex formation.

    PubMed

    Hung, Cheng-Hsiang; Chang, Wen-Wei; Liu, Ssu-Ching; Wu, Shang-Jung; Chu, Chih-Chien; Tsai, Ya-Ju; Imae, Toyoko

    2015-05-01

    In this research, we successfully performed a "click" synthesis of amphiphilic poly(amido amine) dendron-bearing fullerenyl conjugate (C60 G1 ) using a copper(I)-catalyzed azide-alkyne cycloaddition reaction. The strong hydrophobicity of the C60 moiety induces self-assembly of C60 G1 into core-shell-like "pseudodendrimers" with a uniform size distribution and positively charged peripherals. The pseudodendrimers were well-characterized by atomic force microscopy (AFM), transmission electron microscopy, and dynamic light scattering. On the basis of electrostatic interactions, the polycationic C60 G1 assembly can serve as a nonviral gene vector. An ethidium bromide displacement assay and agarose gel electrophoresis both indicated that C60 G1 assembly forms stable complexes with the cyclic reporter gene (pEGFP-C1) at low nitrogen-to-phosphorous (N/P) ratios. AFM analysis revealed a dynamic complex-formation process, and confirmed the synthesis of C60 G1 /pEGFP-C1 hybrids with a particle dimensions less than 200 nm. Fluorescence microscopy and flow cytometry revealed that 51% of HeLa and 43% of MCF-7 cells are positive to the YOYO-1-labeled hybrids at an N/P ratio of 2, being comparable to TurboFect-mediated delivery. PMID:25088044

  16. In-situ stress measurement in an earthquake focal area

    NASA Astrophysics Data System (ADS)

    Tsukahara, H.; Ikeda, R.; Omura, K.

    1996-09-01

    A 2-km-deep borehole was drilled into granitic rock where many shallow earthquakes, with focal depths from 2 to 15 km, have occurred. The drill site, Ashio, is 100 km north of Tokyo. Downhole testing and measurements were conducted five times: four times after each 500 m drilling and the fifth time after completing the 2000 m borehole. Measurements of in-situ stress orientation and magnitude were conducted by the hydraulic fracturing method, stress-induced well bore breakout analysis, and drilling-mud pressure induced hydraulic fracturing analysis. Breakouts and mud pressure induced hydraulic fractures were observed below 650 m and 1250 m, respectively. The circular well bore is maintained only in limited spots below 650 m because of breakouts indicating a large differential stress condition between the maximum and the minimum principal stresses. The differential stress is calculated at 90 ± 20 MPa at the depth of 2000 m based on the condition under which the breakout with some degree of width appears. It is interpreted that this large differential stress is representative of the regional crustal stress condition in the earthquake swarm area. Each spot of the circular well bore is always adjacent to a fracture zone. This suggests that the fracture zone has small differential stress. The stress values were measured where the well bore is circular by the hydraulic fracturing method. For example, the maximum and the minimum horizontal compressive stresses are about 35 MPa and about 25 MPa, respectively, at the depth of 1650 m; giving the differential stress of 10 MPa. The water pressure in pre-existing fractures was also measured, and found that they were nearly equal to the hydrostatic water pressure at the corresponding depths. The stress direction estimated from the azimuth of the breakouts and the hydraulic fracture is consistent with that estimated from the earthquake focal mechanisms. These results support the following conclusions. The differential stress is

  17. Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures.

    PubMed

    Wagner, Fabien B; Eskandar, Emad N; Cosgrove, G Rees; Madsen, Joseph R; Blum, Andrew S; Potter, N Stevenson; Hochberg, Leigh R; Cash, Sydney S; Truccolo, Wilson

    2015-11-15

    Some of the most clinically consequential aspects of focal epilepsy, e.g. loss of consciousness, arise from the generalization or propagation of seizures through local and large-scale neocortical networks. Yet, the dynamics of such neocortical propagation remain poorly understood. Here, we studied the microdynamics of focal seizure propagation in neocortical patches (4×4 mm) recorded via high-density microelectrode arrays (MEAs) implanted in people with pharmacologically resistant epilepsy. Our main findings are threefold: (1) a newly developed stage segmentation method, applied to local field potentials (LFPs) and multiunit activity (MUA), revealed a succession of discrete seizure stages, each lasting several seconds. These different stages showed characteristic evolutions in overall activity and spatial patterns, which were relatively consistent across seizures within each of the 5 patients studied. Interestingly, segmented seizure stages based on LFPs or MUA showed a dissociation of their spatiotemporal dynamics, likely reflecting different contributions of non-local synaptic inputs and local network activity. (2) As previously reported, some of the seizures showed a peak in MUA that happened several seconds after local seizure onset and slowly propagated across the MEA. However, other seizures had a more complex structure characterized by, for example, several MUA peaks, more consistent with the succession of discrete stages than the slow propagation of a simple wavefront of increased MUA. In both cases, nevertheless, seizures characterized by spike-wave discharges (SWDs, ~2-3 Hz) eventually evolved into patterns of phase-locked MUA and LFPs. (3) Individual SWDs or gamma oscillation cycles (25-60 Hz), characteristic of two different types of recorded seizures, tended to propagate with varying degrees of directionality, directions of propagation and speeds, depending on the identified seizure stage. However, no clear relationship was observed between the MUA

  18. The Whipple Mission: Design and development of the focal plane

    NASA Astrophysics Data System (ADS)

    Kenter, A.; Kraft, R.; Murray, S. S.; Gauron, T.; Alcock, C.; Vrtilek, J.

    2014-12-01

    Whipple is a proposed space borne mission intended to detect and characterize thesize and spatial distribution of Trans Neptunian Objects (TNOs) using the ``blind'' occultation technique. This technique measures the size of, and distance to, a TNO by discerning features of the Fresnel diffraction pattern that is produced when a TNO intercepts the light path between a distant star and the observatory. As the observatory transects the diffraction pattern, it resolves that pattern as a light curve using a differential photometer. The light curve decrement is relatively large (few percent) and the temporal duration is short. For a TNO in the Kuiper Belt the duration is a fraction of a second. For objects in the Oort cloud the duration is ~ a few seconds. Since a blind occultation event is rare, tens of thousands of stars need to be observed simultaneously over several years to accumulate sufficient statistics. Stars need to be observed at cadences up to 40 Hz with a read noise <20e rms (post CDS)Though this is beyond the capability of CCDs, such a high speed, low noise, multi-object differential photometer instrument can be implemented with CMOS imaging technology. The proposed focal plane for the Whipple photometer consists of nine Teledyne HyVISI Silicon hybrid CMOS detectors behind a 77cm F1.34 optic. The detectors consist of 1k by 1k 36 micron pitch pixels and each detector is connected to its own SIDECAR ASIC. Due to the high cadence required, the detectors are operatedin window readout mode. Approximately 700 stars per detector, each in a 2x2 pixel window, will be read out at 40Hz. Progressively more stars can be observed as the cadence decreases, until the limit of the SIDECAR memory is reached at about 4,000 windows The lack of atmospheric turbulence combined with the large field of view and high, speed low noise performance of the focal plane will provide the Whipple mission with unprecedented capability in exploring our Solar System.

  19. System and method for generating a deselect mapping for a focal plane array

    SciTech Connect

    Bixler, Jay V; Brandt, Timothy G; Conger, James L; Lawson, Janice K

    2013-05-21

    A method for generating a deselect mapping for a focal plane array according to one embodiment includes gathering a data set for a focal plane array when exposed to light or radiation from a first known target; analyzing the data set for determining which pixels or subpixels of the focal plane array to add to a deselect mapping; adding the pixels or subpixels to the deselect mapping based on the analysis; and storing the deselect mapping. A method for gathering data using a focal plane array according to another embodiment includes deselecting pixels or subpixels based on a deselect mapping; gathering a data set using pixels or subpixels in a focal plane array that are not deselected upon exposure thereof to light or radiation from a target of interest; and outputting the data set.

  20. Simple tools for simulating phased array focal laws on 3D solids

    NASA Astrophysics Data System (ADS)

    Weber, Walter H.; Mair, H. Douglas; Frazer, Leigh

    2001-04-01

    This paper reports our progress on the development of a three-dimensional raytracing program that can simulate the focal laws of a phased array system. The modeled transducer is divided into elements of a given length, width and inter-element gap distance. Each focal law to be modeled requires a steering angle, focal length and selection of which groups of elements are transmitting and receiving. Electronic scanning is simulated by stepping through a series of predefined focal laws. The program phase shifts and sums the received rays at each element based on the properties of the currently-active focal law. Simulated A-scans are constructed from the received rays which appear animated as the beam is swept. Beam profiles can also be generated that show the primary forward beam and energy in the side lobes. The work is based on Imagine3D ultrasonic simulation software and the dedicated efforts of Doug Mair and Leigh Frazer.

  1. Description of focal liver lesions with Gd-EOB-DTPA enhanced MRI

    PubMed Central

    CARAIANI, COSMIN-NICOLAE; DAN, MARIAN; FENESAN, DIANA-IOANA; BADEA, RADU

    2015-01-01

    Imaging procedures play a fundamental role in the therapeutic management of focal liver lesions. The goals of imaging are to detect and correctly characterize focal liver lesions. This review highlights the performances of newer, liver-specific, contrast media in the diagnosis of focal liver lesions, particularly Gd-EOB-DTPA (Primovist), the most frequently used liver specific contrast media. It has been shown, in different papers, that Gd-EOB-DTPA has better performances compared to either triphasic contrast enhanced computed tomography or dynamic MRI in both detection and characterization of hepatocellular carcinoma on the cirrhotic liver. Therefore liver MRI with Primovist is considered, in many centers, the “state-of-the-art” imaging examination of the liver before surgery or liver transplantation. Gd-EOB-DTPA is also useful in the differential diagnosis of benign hypervascular focal liver lesions such as adenomas or focal nodular hyperplasias. PMID:26733231

  2. Individual Assessment of Brain Tissue Changes in MS and the Effect of Focal Lesions on Short-Term Focal Atrophy Development in MS: A Voxel-Guided Morphometry Study

    PubMed Central

    Fox, Jan; Kraemer, Matthias; Schormann, Thorsten; Dabringhaus, Andreas; Hirsch, Jochen; Eisele, Philipp; Szabo, Kristina; Weiss, Christel; Amann, Michael; Weier, Katrin; Naegelin, Yvonne; Kappos, Ludwig; Gass, Achim

    2016-01-01

    We performed voxel-guided morphometry (VGM) investigating the mechanisms of brain atrophy in multiple sclerosis (MS) related to focal lesions. VGM maps detect regional brain changes when comparing 2 time points on high resolution T1-weighted (T1w) magnetic resonace imaging (MRI). Two T1w MR datasets from 92 relapsing-remitting MS patients obtained 12 months apart were analysed with VGM. New lesions and volume changes of focal MS lesions as well as in the surrounding tissue were identified by visual inspection on colour coded VGM maps. Lesions were dichotomized in active and inactive lesions. Active lesions, defined by either new lesions (NL) (volume increase > 5% in VGM), chronic enlarging lesions (CEL) (pre-existent T1w lesions with volume increase > 5%), or chronic shrinking lesions (CSL) (pre-existent T1w lesions with volume reduction > 5%) in VGM, were accompanied by tissue shrinkage in surrounding and/or functionally related regions. Volume loss within the corpus callosum was highly correlated with the number of lesions in its close proximity. Volume loss in the lateral geniculate nucleus was correlated with lesions along the optic radiation. VGM analysis provides strong evidence that all active lesion types (NL, CEL, and CSL) contribute to brain volume reduction in the vicinity of lesions and/or in anatomically and functionally related areas of the brain. PMID:27043553

  3. Individual Assessment of Brain Tissue Changes in MS and the Effect of Focal Lesions on Short-Term Focal Atrophy Development in MS: A Voxel-Guided Morphometry Study.

    PubMed

    Fox, Jan; Kraemer, Matthias; Schormann, Thorsten; Dabringhaus, Andreas; Hirsch, Jochen; Eisele, Philipp; Szabo, Kristina; Weiss, Christel; Amann, Michael; Weier, Katrin; Naegelin, Yvonne; Kappos, Ludwig; Gass, Achim

    2016-01-01

    We performed voxel-guided morphometry (VGM) investigating the mechanisms of brain atrophy in multiple sclerosis (MS) related to focal lesions. VGM maps detect regional brain changes when comparing 2 time points on high resolution T1-weighted (T1w) magnetic resonace imaging (MRI). Two T1w MR datasets from 92 relapsing-remitting MS patients obtained 12 months apart were analysed with VGM. New lesions and volume changes of focal MS lesions as well as in the surrounding tissue were identified by visual inspection on colour coded VGM maps. Lesions were dichotomized in active and inactive lesions. Active lesions, defined by either new lesions (NL) (volume increase > 5% in VGM), chronic enlarging lesions (CEL) (pre-existent T1w lesions with volume increase > 5%), or chronic shrinking lesions (CSL) (pre-existent T1w lesions with volume reduction > 5%) in VGM, were accompanied by tissue shrinkage in surrounding and/or functionally related regions. Volume loss within the corpus callosum was highly correlated with the number of lesions in its close proximity. Volume loss in the lateral geniculate nucleus was correlated with lesions along the optic radiation. VGM analysis provides strong evidence that all active lesion types (NL, CEL, and CSL) contribute to brain volume reduction in the vicinity of lesions and/or in anatomically and functionally related areas of the brain. PMID:27043553

  4. Low cost point focus solar concentrator, phase 1

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Design concepts and plans for mass-production facilities and equipment, field installation, and maintenance were developed and used for cost analysis of a pneumatically stabilized plastic film point focus solar concentrator which has potential application in conjunction with Brayton cycle engines or supply of thermal energy. A sub-scale reflector was fabricated and optically tested by laser ray tracing to determine focal deviations of the surface slope and best focal plane. These test data were then used for comparisons with theoretical concentrator performance modeling and predictions of full-scale design performance. Results of the economic study indicate the concentrator design will have low cost when mass-produced and has cost/performance parameters that fall within current Jet Propulsion Laboratory goals.

  5. Collection of photogenerated charge carriers in small-pitched infrared photovoltaic focal plane arrays

    NASA Astrophysics Data System (ADS)

    Chekanova, Galina V.; Drugova, Albina A.; Kholodnov, Viacheslav; Nikitin, Mikhail S.

    2010-10-01

    Technology of infrared (IR) photovoltaic (PV) focal plane arrays (FPA) covering spectral range from 1.6 to 14 μm gradually moves from simple quasi-matrix (linear) arrays like as 4×288 pixels to large format high definition arrays 1280×1024 pixels and more. Major infrared detector materials for PV technology are InSb and its alloys and ternary alloys Hg1-xCdxTe. Progress in IR PV technology was provided in last decade by serious improvement in material growing techniques. Increasing of PV array format is related always to decreasing of pixel size and spacing between neighbor pixels to minimal size reasonable from point of view of infrared physics. So pitch is small (15-25 μm) in large format arrays. Ambipolar diffusion length of photogenerated charge carriers can exceed pitch many times in high quality absorption layers of PV arrays. It means that each pixel can collect excess charge carriers generated far from n+-p junction border. Optimization of resolution, filling factor and cross-talking level of small-pitched PV FPA requires comprehensive estimation of photodiode's (PD) pixel performance depending on pixel and array design, material properties and operating conditions. Objective of the present work was to develop general approach to estimate collection of photogenerated charge carriers in small-pitched arrays.

  6. Impacts of N-Butylphthalide on expression of growth factors in rats with focal cerebral ischemia

    PubMed Central

    Jiang, Yan; Sun, Leyu; Xuan, Xiaoyan; Wang, Jianping

    2016-01-01

    This study investigates the impacts of n-butylphthalide (NBP) on the expression of vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) in rats with focal cerebral ischemia. The thread embolization method was used to prepare the rat model of cerebral ischemia-reperfusion (CIR). The animals were divided into a sham operation group, a model control group and NBP treatment group. The NBP group was orally administered 25 mg/kg NBP twice a day after the surgery. The immunohistochemistry and reverse transcription-polymerase chain reaction were performed to observe the protein and mRNA expressions of VEGF and TGF-β 16 hours, 1 day and 2 days after inducing CIR. The mRNA and protein expressions of VEGF and TGF-β1 in the model control group and the NBP treatment group were all increased after CIR, and those of the NBP treatment group at each post-CIR time point were higher than the model control group (p < 0.01). After CIR, the expressions of VEGF and TGF-β1 increased, suggesting that VEGF and TGF-β1 exhibited protective effects towards the ischemic brain injuries, and that NBP could upregulate the expressions of VEGF and TGF-β1 in the peri-infarcted area, thus possibly protecting the ischemic brain tissues through this mechanism. PMID:26773175

  7. Interval analysis of interictal EEG: pathology of the alpha rhythm in focal epilepsy

    NASA Astrophysics Data System (ADS)

    Pyrzowski, Jan; Siemiński, Mariusz; Sarnowska, Anna; Jedrzejczak, Joanna; Nyka, Walenty M.

    2015-11-01

    The contemporary use of interictal scalp electroencephalography (EEG) in the context of focal epilepsy workup relies on the visual identification of interictal epileptiform discharges. The high-specificity performance of this marker comes, however, at a cost of only moderate sensitivity. Zero-crossing interval analysis is an alternative to Fourier analysis for the assessment of the rhythmic component of EEG signals. We applied this method to standard EEG recordings of 78 patients divided into 4 subgroups: temporal lobe epilepsy (TLE), frontal lobe epilepsy (FLE), psychogenic nonepileptic seizures (PNES) and nonepileptic patients with headache. Interval-analysis based markers were capable of effectively discriminating patients with epilepsy from those in control subgroups (AUC~0.8) with diagnostic sensitivity potentially exceeding that of visual analysis. The identified putative epilepsy-specific markers were sensitive to the properties of the alpha rhythm and displayed weak or non-significant dependences on the number of antiepileptic drugs (AEDs) taken by the patients. Significant AED-related effects were concentrated in the theta interval range and an associated marker allowed for identification of patients on AED polytherapy (AUC~0.9). Interval analysis may thus, in perspective, increase the diagnostic yield of interictal scalp EEG. Our findings point to the possible existence of alpha rhythm abnormalities in patients with epilepsy.

  8. Focal nodular hyperplasia of the liver: an emerging complication of hematopoietic SCT in children.

    PubMed

    Pillon, M; Carucci, N S; Mainardi, C; Carraro, E; Zuliani, M; Chemello, L; Calore, E; Tumino, M; Varotto, S; Toffolutti, T; Destro, R; Gazzola, M V; Alaggio, R; Basso, G; Messina, C

    2015-03-01

    Hepatic focal nodular hyperplasia (FNH) is a nonmalignant condition rarely affecting children previously treated for cancer, especially those who received hematopoietic SCT (HSCT). Some aspects of its pathogenesis still remain unclear and a strong association with specific risk factors has not yet been identified. We report here a single institution's case series of 17 patients who underwent HSCT and were diagnosed with FNH, analyzing retrospectively their clinical features and the radiological appearance of their hepatic lesions. We aimed to compare the diagnostic accuracy of ultrasound (US) and magnetic resonance imaging (MRI) and to explore the role of transient elastography (FibroScan) to evaluate the degree of hepatic fibrosis in FNH patients. Our analysis showed an association of FNH with age at transplant ⩽12 years (hazard ratio (HR) 9.10); chronic GVHD (HR 2.99); hormone-replacement therapy (HR 4.02) and abdominal radiotherapy (HR 4.37). MRI proved to be a more accurate diagnostic tool compared with US. Nine out of 12 patients who underwent FibroScan showed hepatic fibrosis. Our study points out that FNH is an emerging complication of HSCT, which requires a lifelong surveillance to follow its course in cancer patients. PMID:25581411

  9. Reconstruction of 60 Years of Chikungunya Epidemiology in the Philippines Demonstrates Episodic and Focal Transmission

    PubMed Central

    Salje, Henrik; Cauchemez, Simon; Alera, Maria Theresa; Rodriguez-Barraquer, Isabel; Thaisomboonsuk, Butsaya; Srikiatkhachorn, Anon; Lago, Catherine B.; Villa, Daisy; Klungthong, Chonticha; Tac-An, Ilya A.; Fernandez, Stefan; Velasco, John Mark; Roque, Vito G.; Nisalak, Ananda; Macareo, Louis R.; Levy, Jens W.; Cummings, Derek; Yoon, In-Kyu

    2016-01-01

    Proper understanding of the long-term epidemiology of chikungunya has been hampered by poor surveillance. Outbreak years are unpredictable and cases often misdiagnosed. Here we analyzed age-specific data from 2 serological studies (from 1973 and 2012) in Cebu, Philippines, to reconstruct both the annual probability of infection and population-level immunity over a 60-year period (1952–2012). We also explored whether seroconversions during 2012–2013 were spatially clustered. Our models identified 4 discrete outbreaks separated by an average delay of 17 years. On average, 23% (95% confidence interval [CI], 16%–37%) of the susceptible population was infected per outbreak, with >50% of the entire population remaining susceptible at any point. Participants who seroconverted during 2012–2013 were clustered at distances of <230 m, suggesting focal transmission. Large-scale outbreaks of chikungunya did not result in sustained multiyear transmission. Nevertheless, we estimate that >350 000 infections were missed by surveillance systems. Serological studies could supplement surveillance to provide important insights on pathogen circulation. PMID:26410592

  10. Radiobiological characterization of post-lumpectomy focal brachytherapy with lipid nanoparticle-carried radionuclides

    NASA Astrophysics Data System (ADS)

    Hrycushko, Brian A.; Gutierrez, Alonso N.; Goins, Beth; Yan, Weiqiang; Phillips, William T.; Otto, Pamela M.; Bao, Ande

    2011-02-01

    Post-operative radiotherapy has commonly been used for early stage breast cancer to treat residual disease. The primary objective of this work was to characterize, through dosimetric and radiobiological modeling, a novel focal brachytherapy technique which uses direct intracavitary infusion of β-emitting radionuclides (186Re/188Re) carried by lipid nanoparticles (liposomes). Absorbed dose calculations were performed for a spherical lumpectomy cavity with a uniformly injected activity distribution using a dose point kernel convolution technique. Radiobiological indices were used to relate predicted therapy outcome and normal tissue complication of this technique with equivalent external beam radiotherapy treatment regimens. Modeled stromal damage was used as a measure of the inhibition of the stimulatory effect on tumor growth driven by the wound healing response. A sample treatment plan delivering 50 Gy at a therapeutic range of 2.0 mm for 186Re-liposomes and 5.0 mm for 188Re-liposomes takes advantage of the dose delivery characteristics of the β-emissions, providing significant EUD (58.2 Gy and 72.5 Gy for 186Re and 188Re, respectively) with a minimal NTCP (0.046%) of the healthy ipsilateral breast. Modeling of kidney BED and ipsilateral breast NTCP showed that large injected activity concentrations of both radionuclides could be safely administered without significant complications.

  11. Absolute temperature measurements using a two-color QWIP focal plane array

    NASA Astrophysics Data System (ADS)

    Bundas, Jason; Dennis, Richard; Patnaude, Kelly; Burrows, Douglas; Faska, Ross; Sundaram, Mani; Reisinger, Axel; Manitakos, Dan

    2010-04-01

    The infrared photon flux emitted by an object depends not only on its temperature but also on a proportionality factor referred to as its emissivity. Since the latter parameter is usually not known quantitatively a priori, any temperature determination based on single-band radiometric measurements suffers from an inherent uncertainty. Recording photon fluxes in two separate spectral bands can in principle circumvent this limitation. The technique amounts to solving a system of two equations in two unknowns, namely, temperature and emissivity. The temperature derived in this manner can be considered absolute in the sense that it is independent of the emissivity, as long as that emissivity is the same in both bands. QmagiQ has previously developed a 320x256 midwave/longwave staring focal plane array which has been packaged into a dual-band laboratory camera. The camera in question constitutes a natural tool to generate simultaneous and independent emissivity maps and temperature maps of entire two-dimensional scenes, rather than at a single point on an object of interest. We describe a series of measurements we have performed on a variety of targets of different emissivities and temperatures. We examine various factors that affect the accuracy of the technique. They include the influence of the ambient radiation reflected off the target, which must be properly accounted for and subtracted from the collected signal in order to lead to the true target temperature. We also quantify the consequences of spectrally varying emissivities.

  12. Embedded nonuniformity correction in infrared focal plane arrays using the Constant Range algorithm

    NASA Astrophysics Data System (ADS)

    Redlich, Rodolfo; Figueroa, Miguel; Torres, Sergio N.; Pezoa, Jorge E.

    2015-03-01

    We present a digital fixed-point architecture that performs real-time nonuniformity correction in infrared (IR) focal plane arrays using the Constant Range algorithm. The circuit estimates and compensates online the gains and offsets of a first-order nonuniformity model using pixel statistics from the video stream. We demonstrate our architecture with a prototype built on a Xilinx Spartan-6 XC6SLX45T field-programmable gate array (FPGA), which can process an IR video stream from a FLIR Tau 2 long-wave IR camera with a resolution of 640 × 480 14-bit pixels at up to 238 frames per second (fps) with low resource utilization and adds only 13 mW to the FPGA power. Post-layout simulations of a custom integrated circuit implementation of the architecture on a 32 nm CMOS process show that the circuit can operate at up to 900 fps at the same resolution, and consume less than 4.5 mW.

  13. Mechanical design of mounts for IGRINS focal plane arrays and field flattening lenses

    NASA Astrophysics Data System (ADS)

    Oh, Jae Sok; Park, Chan; Cha, Sang-Mok; Yuk, In-Soo; Kim, Kang-Min; Chun, Moo-Young; Ko, Kyeongyeon; Oh, Heeyeong; Jeong, Ueejeong; Nah, Jakyoung; Lee, Hanshin; Pavel, Michael; Jaffe, Daniel T.

    2014-07-01

    IGRINS, the Immersion GRating INfrared Spectrometer, is a near-infrared wide-band high-resolution spectrograph jointly developed by the Korea Astronomy and Space Science Institute and the University of Texas at Austin. IGRINS employs three HAWAII-2RG focal plane array (FPA) detectors. The mechanical mounts for these detectors and for the final (field-flattening) lens in the optical train serve a critical function in the overall instrument design: Optically, they permit the only positional compensation in the otherwise "build to print" design. Thermally, they permit setting and control of the detector operating temperature independently of the cryostat bench. We present the design and fabrication of the mechanical mount as a single module. The detector mount includes the array housing, housing for the SIDECAR ASIC, a field flattener lens holder, and a support base. The detector and ASIC housing will be kept at 65 K and the support base at 130 K. G10 supports thermally isolate the detector and ASIC housing from the support base. The field flattening lens holder attaches directly to the FPA array housing and holds the lens with a six-point kinematic mount. Fine adjustment features permit changes in axial position and in yaw and pitch angles. We optimized the structural stability and thermal characteristics of the mount design using computer-aided 3D modeling and finite element analysis. Based on the computer simulation, the designed detector mount meets the optical and thermal requirements very well.

  14. Dewey's Logic as a Methodological Grounding Point for Practitioner-Based Inquiry

    ERIC Educational Resources Information Center

    Demetrion, George

    2012-01-01

    The purpose of this essay is to draw out key insights from Dewey's important text "Logic: The Theory of Inquiry" to provide theoretical and practical support for the emergent field of teacher research. The specific focal point is the argument in Cochran-Smith and Lytle's "Inside/Outside: Teacher Research and Knowledge" on the significance of…

  15. Point-to-Point Multicast Communications Protocol

    NASA Technical Reports Server (NTRS)

    Byrd, Gregory T.; Nakano, Russell; Delagi, Bruce A.

    1987-01-01

    This paper describes a protocol to support point-to-point interprocessor communications with multicast. Dynamic, cut-through routing with local flow control is used to provide a high-throughput, low-latency communications path between processors. In addition multicast transmissions are available, in which copies of a packet are sent to multiple destinations using common resources as much as possible. Special packet terminators and selective buffering are introduced to avoid a deadlock during multicasts. A simulated implementation of the protocol is also described.

  16. Irreversible Electroporation for Focal Ablation at the Porta Hepatis

    SciTech Connect

    Kasivisvanathan, Veeru; Thapar, Ankur Oskrochi, Youssof; Picard, John; Leen, Edward L. S.

    2012-12-15

    Patients with chemotherapy-refractory liver metastases who are not candidates for surgery may be treated with focal ablation techniques with established survival benefits. Irreversible electroporation is the newest of these and has the putative advantages of a nonthermal action, preventing damage to adjacent biliary structures and bowel. This report describes the use of irreversible electroporation in a 61-year-old man with a solitary chemoresistant liver metastasis unsuitable for radiofrequency ablation as a result of its proximity to the porta hepatis. At 3 months, tumor size was decreased on computed tomography from 28 Multiplication-Sign 19 to 20 Multiplication-Sign 17 mm, representing stable disease according to the response evaluation criteria in solid tumors. This corresponded to a decrease in tumor volume size from 5.25 to 3.16 cm{sup 3}. There were no early or late complications. Chemoresistant liver metastases in the proximity of the porta hepatis that are considered to be too high a risk for conventional surgery or thermal ablation may be considered for treatment by the novel ablation technique of irreversible electroporation.

  17. Cognitive and psychological functioning in focal dermal hypoplasia.

    PubMed

    Deidrick, Kathleen K M; Early, Martha; Constance, Jordan; Stein, Margot; Fete, Timothy J

    2016-03-01

    Focal dermal hypoplasia (FDH) is a condition caused by heterozygous mutation of the PORCN gene on chromosome Xp22.3. It impacts the primitive ectoderm and mesoderm, affecting skin, teeth, nails, hair, musculoskeletal development, and vision and hearing. To date, there has been no systematic research examining the psychoeducational impact of the disorder. The current study examined emotional, behavioral, adaptive, and intellectual ability in 17 subjects with ages ranging from 3 to 55 with FDH attending the 2013 Annual Family Conference of the National Foundation for Ectodermal Dysplasias. Findings suggested overall average functioning in all areas. However, wide variability was noted in this sample, with 3 participants (18%) exhibiting overall cognitive ability in the borderline to impaired range. These findings are consistent with previous reports suggesting intellectual impairment in 15% of persons with FDH. Similarly, a subgroup of children was rated by parents as exhibiting difficulties with behavior (2 out of 11; 18%) and emotions (5 out of 11; 45%). Of particular concern was withdrawn behavior, reported by 65% of parents. These findings suggest that clinicians should routinely screen persons with FDH to rule out cognitive and emotional/behavioral difficulties and offer timely treatment. Future research should focus on identifying risk factors for psychoeducational problems in this population. © 2016 Wiley Periodicals, Inc. PMID:26818018

  18. Advancement in 17-micron pixel pitch uncooled focal plane arrays

    NASA Astrophysics Data System (ADS)

    Li, Chuan; Skidmore, George; Howard, Christopher; Clarke, Elwood; Han, C. J.

    2009-05-01

    This paper provides an update of 17 micron pixel pitch uncooled microbolometer development at DRS. Since the introduction of 17 micron pitch 640x480 focal plane arrays (FPAs) in 2006, significant progress has been made in sensor performance and manufacturing processes. The FPAs are now in initial production with an FPA noise equivalent temperature difference (NETD), detector thermal time constant, and pixel operability equivalent or better than that of the current 25 micron pixel pitch production FPAs. NETD improvement was achieved without compromising detector thermal response or thermal time constant by simultaneous reduction in bolometer heat capacity and thermal conductance. In addition, the DRS unique "umbrella" microbolometer cavities were optically tuned to optimize detector radiation absorption for specific spectral band applications. The 17 micron pixel pitch FPAs are currently being considered for the next generation soldier systems such as thermal weapon sights (TWS), vehicle driver vision enhancers (DVE), digitally fused enhanced night vision goggles (DENVG) and unmanned air vehicle (UAV) surveillance sensors, because of overall thermal imaging system size, weight and power advantages.

  19. Neural substrates of spontaneous narrative production in focal neurodegenerative disease.

    PubMed

    Gola, Kelly A; Thorne, Avril; Veldhuisen, Lisa D; Felix, Cordula M; Hankinson, Sarah; Pham, Julie; Shany-Ur, Tal; Schauer, Guido P; Stanley, Christine M; Glenn, Shenly; Miller, Bruce L; Rankin, Katherine P

    2015-12-01

    Conversational storytelling integrates diverse cognitive and socio-emotional abilities that critically differ across neurodegenerative disease groups. Storytelling patterns may have diagnostic relevance and predict anatomic changes. The present study employed mixed methods discourse and quantitative analyses to delineate patterns of storytelling across focal neurodegenerative disease groups, and to clarify the neuroanatomical contributions to common storytelling characteristics. Transcripts of spontaneous social interactions of 46 participants (15 behavioral variant frontotemporal dementia (bvFTD), 7 semantic variant primary progressive aphasia (svPPA), 12 Alzheimer's disease (AD), and 12 healthy older normal controls (NC)) were analyzed for storytelling frequency and characteristics, and videos of the interactions were rated for patients' level of social attentiveness. Compared to controls, svPPAs told more stories and autobiographical stories, and perseverated on aspects of self during the interaction, whereas ADs told fewer autobiographical stories than NCs. svPPAs and bvFTDs were rated as less attentive to social cues. Aspects of storytelling were related to diverse cognitive and socio-emotional functions, and voxel-based anatomic analysis of structural magnetic resonance imaging revealed that temporal organization, narrative evaluations patterns, and social attentiveness correlated with atrophy corresponding to known intrinsic connectivity networks, including the default mode, limbic, salience, and stable task control networks. Differences in spontaneous storytelling among neurodegenerative groups elucidated diverse cognitive, socio-emotional, and neural contributions to narrative production, with implications for diagnostic screening and therapeutic intervention. PMID:26485159

  20. Cosmology Large Angular Scale Surveyor (CLASS) Focal Plane Development

    NASA Astrophysics Data System (ADS)

    Chuss, D. T.; Ali, A.; Amiri, M.; Appel, J.; Bennett, C. L.; Colazo, F.; Denis, K. L.; Dünner, R.; Essinger-Hileman, T.; Eimer, J.; Fluxa, P.; Gothe, D.; Halpern, M.; Harrington, K.; Hilton, G.; Hinshaw, G.; Hubmayr, J.; Iuliano, J.; Marriage, T. A.; Miller, N.; Moseley, S. H.; Mumby, G.; Petroff, M.; Reintsema, C.; Rostem, K.; U-Yen, K.; Watts, D.; Wagner, E.; Wollack, E. J.; Xu, Z.; Zeng, L.

    2016-08-01

    The Cosmology Large Angular Scale Surveyor (CLASS) will measure the polarization of the Cosmic Microwave Background to search for and characterize the polarized signature of inflation. CLASS will operate from the Atacama Desert and observe ˜ 70 % of the sky. A variable-delay polarization modulator provides modulation of the polarization at ˜ 10 Hz to suppress the 1/ f noise of the atmosphere and enable the measurement of the large angular scale polarization modes. The measurement of the inflationary signal across angular scales that spans both the recombination and reionization features allows a test of the predicted shape of the polarized angular power spectra in addition to a measurement of the energy scale of inflation. CLASS is an array of telescopes covering frequencies of 38, 93, 148, and 217 GHz. These frequencies straddle the foreground minimum and thus allow the extraction of foregrounds from the primordial signal. Each focal plane contains feedhorn-coupled transition-edge sensors that simultaneously detect two orthogonal linear polarizations. The use of single-crystal silicon as the dielectric for the on-chip transmission lines enables both high efficiency and uniformity in fabrication. Integrated band definition has been implemented that both controls the bandpass of the single-mode transmission on the chip and prevents stray light from coupling to the detectors.