Science.gov

Sample records for 4-substituted pent-4-enylamines scope

  1. 40 CFR 721.10043 - Dineopentyl-4-substituted phthalate (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Dineopentyl-4-substituted phthalate... Specific Chemical Substances § 721.10043 Dineopentyl-4-substituted phthalate (generic). (a) Chemical... as dineopentyl-4-substituted phthalate (PMN P-02-697) is subject to reporting under this section for...

  2. 40 CFR 721.10043 - Dineopentyl-4-substituted phthalate (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Dineopentyl-4-substituted phthalate... Specific Chemical Substances § 721.10043 Dineopentyl-4-substituted phthalate (generic). (a) Chemical... as dineopentyl-4-substituted phthalate (PMN P-02-697) is subject to reporting under this section for...

  3. Electronic properties of 4-substituted naphthalimides.

    PubMed

    Kucheryavy, Pavel; Li, Guifeng; Vyas, Shubham; Hadad, Christopher; Glusac, Ksenija D

    2009-06-11

    This paper describes a study of excited-state properties of naphthalimide (NI) and four 4-substituted derivatives: 4-chloronaphthalimide (Cl-NI), 4-methylthionaphthalimide (MeS-NI), 4-nitronaphthalimide (O(2)N-NI), and 4-(N,N-dimethylaminonaphthalimide (Me(2)N-NI). Steady-state absorption and fluorescence spectra were collected in solvents of varying polarity to determine the excited-state character of NI derivatives. Furthermore, the excited-state dynamics were studied using femtosecond transient absorption spectroscopy. The experimental findings were compared to calculated data obtained using time-dependent density functional (TD-DFT) methods. We found that light absorption by all NI derivatives leads to the production of the second excited state (S(2)), which was found to have a n,pi* character. Within approximately 40 ps, the S(2) state undergoes internal conversion to produce the S(1) state. The S(1) state is relatively long-lived (approximately 4 ns) and has charge-transfer character in NI derivatives with electron-withdrawing and electron-donating groups (MeS-NI, O(2)N-NI, and Me(2)N-NI). In the case of NI and Cl-NI, the S(1) state has a pi,pi* character and undergoes intersystem crossing to produce the T(1) state within 400 ps.

  4. Facile Preparation of 4-Substituted Quinazoline Derivatives.

    PubMed

    Wang, Daniel Z; Yan, Lesong; Ma, Lingmei

    2016-02-15

    Reported in this paper is a very simple method for direct preparation of 4-substituted quinazoline derivatives from a reaction between substituted 2-aminobenzophenones and thiourea in the presence of dimethyl sulfoxide (DMSO). This is a unique complementary reaction system in which thiourea undergoes thermal decomposition to form carbodiimide and hydrogen sulfide, where the former reacts with 2-aminobenzophenone to form 4-phenylquinazolin-2(1H)-imine intermediate, whilst hydrogen sulfide reacts with DMSO to give methanethiol or other sulfur-containing molecule which then functions as a complementary reducing agent to reduce 4-phenylquinazolin-2(1H)-imine intermediate into 4-phenyl-1,2-dihydroquinazolin-2-amine. Subsequently, the elimination of ammonia from 4-phenyl-1,2-dihydroquinazolin-2-amine affords substituted quinazoline derivative. This reaction usually gives quinazoline derivative as a single product arising from 2-aminobenzophenone as monitored by GC/MS analysis, along with small amount of sulfur-containing molecules such as dimethyl disulfide, dimethyl trisulfide, etc. The reaction usually completes in 4-6 hr at 160 ºC in small scale but may last over 24 hr when carried out in large scale. The reaction product can be easily purified by means of washing off DMSO with water followed by column chromatography or thin layer chromatography.

  5. Flexible, phase-transfer catalyzed approaches to 4-substituted prolines.

    PubMed

    Johnston, Heather J; McWhinnie, Fergus S; Landi, Felicetta; Hulme, Alison N

    2014-09-19

    A range of 4-substituted prolines can be rapidly synthesized from a protected glycine Schiff base in only four steps and in 27-55% overall yield. Phase transfer catalysis allows direct access to both enantiomeric series, and the relative stereochemistry at the 4-position is readily controlled (>10:1 dr) through the choice of hydrogenation conditions.

  6. Design, synthesis and anticonvulsant evaluation of novel N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothio amides.

    PubMed

    Tripathi, Laxmi; Kumar, Praveen; Singh, Ranjit; Stables, James P

    2012-01-01

    Thirty six new N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothioamides were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The anticonvulsant activity was established in three seizure models i.e. MES, scMET and 6 Hz model. The most active compound was 2-[4-(4-chlorophenoxy)benzylidene]-N-(4-fluorophenyl)hydrazinecarbothioamide PC 31 which showed 100% protection at 0.5 h in the 6 Hz test. Compound 2-[4-(4-bromophenoxy) benzylidene]-N-(4-bromophenyl) hydrazinecarbothioamide PC 23 was found to be active in both the MES and 6 Hz test. A computational study was carried out from calculation of a pharmacophore pattern and the prediction of pharmacokinetic properties. Titled compounds have also exhibited good binding properties with epilepsy molecular targets such as glutamate, GABA (A) delta and GABA (A) alpha-1 receptors, in the Lamarckian genetic algorithm based on flexible docking studies.

  7. Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines.

    PubMed

    Rueping, Magnus; Theissmann, Thomas; Stoeckel, Mirjam; Antonchick, Andrey P

    2011-10-07

    A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity.

  8. Selective Access to 4-Substituted 2-Aminothiazoles and 4-Substituted 5-Thiocyano-2-aminothiazoles from Vinyl Azides and Potassium Thiocyanate Switched by Palladium and Iron Catalysts.

    PubMed

    Chen, Binhui; Guo, Shanshan; Guo, Xiao; Zhang, Guolin; Yu, Yongping

    2015-10-02

    A highly selective construction of 4-substituted 2-aminothiazoles and 4-substituted 5-thiocyano-2-aminothiazoles, respectively, catalyzed by palladium(II) acetate and promoted by iron(III) bromide from vinyl azides and potassium thiocyanate has been developed. Use of readily available starting materials, high selectivity, as well as mild reaction conditions make this practical method particularly attractive.

  9. Enantioselective sp(3) C-H alkylation of γ-butyrolactam by a chiral Ir(I) catalyst for the synthesis of 4-substituted γ-amino acids.

    PubMed

    Tahara, Yu-ki; Michino, Masamichi; Ito, Mamoru; Kanyiva, Kyalo Stephen; Shibata, Takanori

    2015-12-04

    Ir-catalyzed sp(3) C-H alkylation of γ-butyrolactam with alkenes was used for the highly enantioselective synthesis of 5-substituted γ-lactams, which were readily converted into chiral 4-substituted γ-amino acids. A broad scope of alkenes was amenable as coupling partners, and the alkylated product using acrylate could be transformed into the key intermediate of pyrrolam A synthesis.

  10. Specificity of aspartate aminotransferases from leguminous plants for 4-substituted glutamic acids.

    PubMed

    Winter, H C; Dekker, E E

    1989-04-01

    Aspartate aminotransferase (glutamate-oxalacetate transaminase) was partially purified from extracts of germinating seeds of peanut (Arachis hypogaea), honey locust (Gleditsia triacanthos), soybean (Glycine max), and Sophora japonica. The ability of these enzyme preparations, as well as aspartate aminotransferase purified from pig heart cytosol, to use 4-substituted glutamic acids as amino group donors and their corresponding 2-oxo acids as amino group acceptors in the aminotransferase reaction was measured. All 4-substituted glutamic acid analogs tested were poorer substrates than was glutamate or 2-oxoglutarate. 2-Oxo-4-methyleneglutarate was least effective (lowest relative V(m)/K(m)) as a substrate for the enzyme from peanuts and honey locust, which are the two species studied that accumulate 4-methyleneglutamic acid and 4-methyleneglutamine. Of the different aminotransferases tested, the enzyme from honey locust was the least active with 2-oxo-4-hydroxy-4-methylglutarate, the corresponding amino acid of which also accumulates in that species. These results suggest that transamination of 2-oxo-4-substituted glutaric acids is not involved in the biosynthesis of the corresponding 4-substituted glutamic acids in these species. Rather, accumulation of certain 4-substituted glutamic acids in these instances may be, in part, the result of the inefficacy of their transamination by aspartate aminotransferase.

  11. Specificity of Aspartate Aminotransferases from Leguminous Plants for 4-Substituted Glutamic Acids 1

    PubMed Central

    Winter, Harry C.; Dekker, Eugene E.

    1989-01-01

    Aspartate aminotransferase (glutamate-oxalacetate transaminase) was partially purified from extracts of germinating seeds of peanut (Arachis hypogaea), honey locust (Gleditsia triacanthos), soybean (Glycine max), and Sophora japonica. The ability of these enzyme preparations, as well as aspartate aminotransferase purified from pig heart cytosol, to use 4-substituted glutamic acids as amino group donors and their corresponding 2-oxo acids as amino group acceptors in the aminotransferase reaction was measured. All 4-substituted glutamic acid analogs tested were poorer substrates than was glutamate or 2-oxoglutarate. 2-Oxo-4-methyleneglutarate was least effective (lowest relative Vm/Km) as a substrate for the enzyme from peanuts and honey locust, which are the two species studied that accumulate 4-methyleneglutamic acid and 4-methyleneglutamine. Of the different aminotransferases tested, the enzyme from honey locust was the least active with 2-oxo-4-hydroxy-4-methylglutarate, the corresponding amino acid of which also accumulates in that species. These results suggest that transamination of 2-oxo-4-substituted glutaric acids is not involved in the biosynthesis of the corresponding 4-substituted glutamic acids in these species. Rather, accumulation of certain 4-substituted glutamic acids in these instances may be, in part, the result of the inefficacy of their transamination by aspartate aminotransferase. PMID:16666674

  12. Apoptosis inducing activity of 4-substituted coumarins from Calophyllum brasiliense in human leukaemia HL-60 cells.

    PubMed

    Ito, Chihiro; Murata, Tomiyasu; Itoigawa, Masataka; Nakao, Keisuke; Kaneda, Norio; Furukawa, Hiroshi

    2006-07-01

    With the objective of identifying anti-tumour-promoting agents, we carried out a primary screening of ten 4-substituted coumarins isolated from Calophyllum brasiliense Camb. (Guttiferae), to determine the ability of these compounds to inhibit proliferation of the human leukaemia cell line HL-60. Among the 4-substituted coumarins isolated, calophyllolide (2) and mammea B/BB (3) showed significant cytotoxicity against HL-60 cells. Fluorescence microscopy with Hoechst 33342 staining revealed that the percentage of apoptotic cells with fragmented nuclei and condensed chromatin increased in a time-dependent manner after treatment with calophyllolide (2) or mammea B/BB (3). In addition, the activity of caspase-9 and caspase-3 was also enhanced in a time-dependent manner upon treatment with the 4-substituted coumarins 2 and 3. Caspase-9 and caspase-3 inhibitors suppressed apoptosis induced by 4-substituted coumarins 2 and 3. These results suggest that calophyllolide (2) and mammea B/ BB (3) induced apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, which is triggered by mitochondrial dysfunction.

  13. An efficient and general enantioselective synthesis of sphingosine, phythosphingosine, and 4-substituted derivatives.

    PubMed

    Llaveria, Josep; Díaz, Yolanda; Matheu, M Isabel; Castillón, Sergio

    2009-01-01

    A general and efficient protocol for the enantioselective synthesis of sphingosine, phythosphingosine, and 4-substituted derivatives was established. These compounds were obtained from a common intermediate prepared from butadiene monoepoxide by a synthetic sequence involving enantioselective allylic substitution, cross-metathesis, and dihydroxylation.

  14. Microbial hydroxylation of o-bromophenylacetic acid: synthesis of 4-substituted-2,3-dihydrobenzofurans.

    PubMed

    Deshpande, Prashant P; Nanduri, Venkata B; Pullockaran, Annie; Christie, Hamish; Mueller, Richard H; Patel, Ramesh N

    2008-08-01

    Microbial hydroxylation of o-bromophenylacetic acid provided 2-bromo-5-hydroxyphenylacetic acid. This enabled a route to the key intermediate 4-bromo-2,3-dihydrobenzofuran for synthesizing a melatonin receptor agonist and sodium hydrogen exchange compounds. Pd-mediated coupling reactions of 4-bromo-2,3-dihydrobenzofuran provided easy access to the 4-substituted-2,3-dihydrobenzofurans.

  15. A General Synthesis of 4-Substituted 6-(2-Imidazolinylamino)-5,8-dimethylquinolines.

    PubMed

    Outt, Pamela E.; Ares, Jeffrey J.; Roberts, George E.; Wang, Xiaodong; Cupps, Thomas L.; Wireko, Fred C.

    1998-08-21

    A general synthesis of 4-substituted 6-(2-imidazolinylamino)-5,8-dimethylquinolines 1 has been developed. All new compounds were synthesized from a common intermediate, 5,8-dimethyl-6-nitro-4-quinolone 3, the structure of which was confirmed by X-ray crystallography. This methodology involved the conversion of 3 into either a 4-chloro- or 4-bromoquinoline followed by the introduction of various 4-substituents late in the synthetic sequence. Substituents introduced in this way include alkyl (18a), alkoxy (12a, 12b), halo (9, 12c, 16), cyano (18b), thioalkyl (12d), acetamido (14), carboxamido (19), and hydroxy (10). This work illustrates the utility of 4-haloquinoline intermediates in the general synthesis of 4-substituted quinolines.

  16. 4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls

    PubMed Central

    Dettori, Maria Antonietta; Fabbri, Davide; Pisano, Marina; Rozzo, Carla; Palmieri, Giuseppe; Dessµ, Alessandro; Dallocchio, Roberto; Delogu, Giovanna

    2015-01-01

    A small collection of eugenol- and curcumin-analog hydroxylated biphenyls was prepared by straightforward methods starting from natural 4-substituted-2-methoxyphenols and their antitumoral activity was evaluated in vitro. Two curcumin-biphenyl derivatives showed interesting growth inhibitory activities on different malignant melanoma cell lines with IC50 ranging from 13 to 1 µM. Preliminary molecular modeling studies were carried out to evaluate conformations and dihedral angles suitable for antiproliferative activity in hydroxylated biphenyls bearing a side aliphatic chain. PMID:26074750

  17. 2,4-Substituted-3-aza-1-thiabutadienes: a conformational study by dipolmetry

    NASA Astrophysics Data System (ADS)

    Cellerin, C.; Abouelfida, A.; Pradère, J. P.; Proutière, A.; Rozé, J. C.; Bouzid, M.; Exner, O.

    1992-01-01

    Dipole moments of fifteen 2,4-substituted4- N,N-dimethylamino-3-aza-1-thia(oxa)butadienes were measured in carbon tetrachloride solution. Calculations of molecular moments for five compounds in the sp (CS and NC on the same side) and ap conformations were performed according to the bond moment model. A comparison of calculated values with the experimental ones shows that the sp conformation is favoured in the solutions studied, in accordance with the reactivity observed for 4+2 cycloadditions.

  18. Enantioselective, protecting group-free synthesis of 1S-ethyl-4-substituted quinolizidines.

    PubMed

    Amat, Mercedes; Semak, Vladislav; Escolano, Carmen; Molins, Elies; Bosch, Joan

    2012-09-14

    A practical enantioselective protecting group-free four-step route to the key quinolizidinone 6 from phenylglycinol-derived bicyclic lactam 1 is reported. The Grignard addition reaction to 6 takes place stereoselectively to give 1-ethyl-4-substituted quinolizidines 4-epi-207I and 7-9. Following a similar synthetic sequence, 9a-epi-6 is also accessed. However, the addition of Grignard reagents to 9a-epi-6 proceeds in a non-stereoselective manner. In order to gain insight into the different stereochemical outcome in the two series, theoretical calculations on the iminium salts A and B have been performed. The study concludes that the addition of the hydride, which is the step that determines the configuration of the final products, occurs in a stereoelectronic controlled manner. The theoretical study is in agreement with the experimental results.

  19. Recent developments of C-4 substituted coumarin derivatives as anticancer agents.

    PubMed

    Dandriyal, Jyoti; Singla, Ramit; Kumar, Manvendra; Jaitak, Vikas

    2016-08-25

    Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. Coumarin scaffold became an attractive subject due to their broad spectrum of pharmacological activities. Coumarin derivatives extensively explored for anticancer activities as it possesses minimum side effect along with multi-drug reversal activity. Coumarin derivatives can act by various mechanisms on different tumor cell lines depending on substitution pattern of the core structure of coumarin. Substitution on coumarin nucleus leads to the search for more potent compounds. In this review, we have made an effort to give a synthetic strategy for the preparation of C-4 substituted coumarin derivatives as anticancer agents based on their mechanism of action and also discuss the SAR of the most active compound.

  20. Synthesis and anti-cancer activities of new sulfonamides 4-substituted-triazolyl nucleosides.

    PubMed

    Alaoui, Soukaina; Dufies, Maeva; Driowya, Mohsine; Demange, Luc; Bougrin, Khalid; Robert, Guillaume; Auberger, Patrick; Pagès, Gilles; Benhida, Rachid

    2017-05-01

    Nucleoside analogues are among the most known drugs commonly used in antiviral and anticancer chemotherapies. Among them, those featuring a five-membered ring nucleobase are of utmost interest such as the anti-cancer agent AICAR or the anti-viral drug ribavirin. Despite its low activity in vitro in different cell lines, AICAR is under clinical development for several pathologies, thanks to its original mode of action. Indeed, AICAR induced autophagy cell death and is able, following this mechanism, to circumvent resistance to apoptotic drugs including kinase inhibitors currently on the market. To improve the activity of AICAR, we report herein an efficient synthesis of new series of sulfonamide-4-substituted-1,2,3-triazolyl nucleosides using a Cu-catalyzed 1,3-dipolar cycloaddition. All these molecules have been fully characterized and evaluated against two aggressive tumor cell lines, RCC4 and MDA-MB-231. Among them, nucleoside analogue 5i belonging to the ribose series was found to be 19 to 66-fold more active than AICAR. Western blot analyses on RCC4 cells showed that 5i displayed an interesting mode of action by inducing both apoptosis and autophagy cell death, making therefore this class of molecules highly promising for further hit-to-lead optimization. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel-Crafts type allylic alkylation of phenols.

    PubMed

    Zhao, Zheng-Le; Xu, Qing-Long; Gu, Qing; Wu, Xin-Yan; You, Shu-Li

    2015-03-14

    Palladium-catalyzed asymmetric intramolecular Friedel-Crafts type allylic alkylation reaction of phenols was developed under mild conditions. In the presence of Pd2(dba)3 with (1R,2R)-DACH-phenyl Trost ligand (L2) in toluene at 50 °C, the reaction provides various C4 substituted tetrahydroisoquinolines with moderate to excellent yields, regioselectivity and enantioselectivity.

  2. Synthesis of C-4-Substituted Steviol Derivatives and Their Inhibitory Effects against Hepatitis B Virus.

    PubMed

    Lin, Shwu-Jiuan; Su, Ta-Chi; Chu, Chin-Nan; Chang, Yi-Chih; Yang, Li-Ming; Kuo, Yu-Cheng; Huang, Tsurng-Juhn

    2016-12-23

    ent-13-Hydroxykaur-16-ene-19-N-butylureide (6) was one of 33 synthesized C-4-substituted steviol derivatives that were evaluated for their effects on hepatitis B virus (HBV) surface antigen (HBsAg) secretion. The IC50 (16.9 μM) and SI (57.7) values for inhibiting HBV DNA replication of compound 6 were greater than those of the reference compound, lamivudine (3-TC; IC50: 107.5 μM; SI: 22.0). Thus, the anti-HBV mechanism of 6 was investigated, and it specifically inhibited viral gene expression and reduced viral DNA levels, as well as potently attenuated all of the viral promoter activity of HBV-expressing Huh7 cells. Examination of cellular signaling pathways found that 6 inhibited the activities of the nuclear factor (NF)-κB- and activator protein (AP)-1 element-containing promoters, but had no effects on AP-2 or interferon-stimulated response element (ISRE)-containing promoters in HBV-expressing cells. Meanwhile, it significantly eliminated NF-κB and extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling-related protein levels and inhibited their phosphorylation in HBV-transfected Huh7 cells. The inhibitory potency of 6 against HBV DNA replication was reversed by cotransfecting the NF-κB p65 expression plasmid. Using the MAPK-specific activator anisomycin also reversed the inhibitory effect of 6 on viral DNA replication. The present findings suggest that the anti-HBV mechanism of 6 is partly mediated through the NF-κB and MAPK signaling pathways.

  3. Planar geometry of 4-substituted-2,2'-bipyridines synthesized by Sonogashira and Suzuki cross-coupling reactions

    SciTech Connect

    Luong Thi, T. T. Nguyen Bich, N.; Nguyen, H.; Van Meervelt, L.

    2015-12-15

    Two 4-substituted 2,2'-bipyridines, namely 4-(ferrocenylethynyl)-2,2'-bipyridine (I) and 4-ferrocenyl-2,2'-bipyridine (II) have been synthesized and fully characterized via single-crystal X-ray diffraction and {sup 1}H and {sup 13}C NMR analyses. The π-conjugated system designed from 2,2'-bipyridine modified with the ferrocenylethynyl and ferrocenyl groups shows the desired planarity. In the crystal packing of I and II, the molecules arrange themselves in head-to-tail and head-to-head motifs, respectively, resulting in consecutive layers of ferrocene and pyridine moieties.

  4. Planar geometry of 4-substituted-2,2'-bipyridines synthesized by Sonogashira and Suzuki cross-coupling reactions

    NASA Astrophysics Data System (ADS)

    Luong Thi, T. T.; Nguyen Bich, N.; Nguyen, H.; Van Meervelt, L.

    2015-12-01

    Two 4-substituted 2,2'-bipyridines, namely 4-(ferrocenylethynyl)-2,2'-bipyridine ( I) and 4-ferrocenyl-2,2'-bipyridine ( II) have been synthesized and fully characterized via single-crystal X-ray diffraction and 1H and 13C NMR analyses. The π-conjugated system designed from 2,2'-bipyridine modified with the ferrocenylethynyl and ferrocenyl groups shows the desired planarity. In the crystal packing of I and II, the molecules arrange themselves in head-to-tail and head-to-head motifs, respectively, resulting in consecutive layers of ferrocene and pyridine moieties.

  5. Design and synthesis of 4-substituted quinazolines as potent EGFR inhibitors with anti-breast cancer activity.

    PubMed

    Ahmed, Marwa; Magdy, Naja

    2016-09-23

    Cancer is a major health problem to human beings around the world. Many quinazoline derivatives were reported to have potent cytotoxic activity. Our aim in this work is the discovery of potent epidermal growth factor receptor (EGFR) inhibitors with anti-breast cancer activity containing 4-substituted quinazoline pharmacophore. Novel series of 4-substituted 6,8-dibromo-2-(4-chlorophenyl)-quinazoline derivatives have been designed and synthesized. New derivatives were tested against MCF-7 (human breast carcinoma cell line) and screened for their inhibition activity against epidermal growth factor receptor tyrosine kinase (EGFR-TK). Most of the tested compounds show potent antiproliferative activity and EGFR-TK inhibitory activity. Compounds VIIIc and VIIIb exerted powerful cytotoxic activity (IC50 3.1 and 6.3 µM) with potent inhibitory percent (91.1 and 88.4%) against EGFR-TK. Compounds IX, VIIa, X, VIIb, VIc, V, IV, VIa and VIb showed promising cytotoxic effects with IC50 range (12-79 µM) with good activity against EGFR-TK with the inhibitory percent (85.4-60.8%). On the other hand, compounds VIIc, VIIIa exerted low cytotoxic effects as revealed from their IC50 value (124 and 144 µM) with low activity against EGFR-TK with inhibitory percent 30.6 and 29.1% respectively.

  6. Strain correlated effect on structural, magnetic, and dielectric properties in Ti4+ substituted Bi0.8Ba0.2Fe1-xTixO3

    NASA Astrophysics Data System (ADS)

    Paul Blessington Selvadurai, A.; Pazhanivelu, V.; Murugaraj, R.

    2015-08-01

    Ti4+ substituted Bi0.8Ba0.2Fe1-xTixO3 for x = 0.0, 0.1 and 0.2 are prepared by modified solid state reaction method. The prepared samples sintered at 850 °C for 1 h show a single phase nature. A structural change was observed on Ti4+ substitutions are confirmed through X-ray Diffraction, Fourier Transform Infrared spectroscopy and Raman spectra. An anomalous phase transition is observed in Bi0.8Ba0.2FeO3 at 1173 K. The absence of ferroelectric transition and enhancement of decomposition temperature is observed in the substituted samples from the thermal analysis. A dielectric spectroscopic measurement shows that on Ti4+ substitutions, the magnitude of dielectric constant and loss tangent (tan δ) value is decreased. Vibrating Sample Magnetometer (VSM) study shows both antiferromagnetic and ferromagnetic phases coexist in the M-H curve. On Ti4+ substitutions in Bi0.8Ba0.2FeO3, the antiferromagnetism dominates over the ferromagnetic phase. In corroboration to magnetisation process, ZFC-FC measurement confirms it that on Ti4+ substitution, the antiferromagnetic behaviour gets dominated. The report suggests that the interplay of strain upon Ti4+ substitution causes the structural and magnetic phase transition.

  7. Synthesis, structure characterization and antimicrobial evaluation of 4-(substituted phenylazo)-3,5-diacetamido-1H-pyrazoles

    NASA Astrophysics Data System (ADS)

    Kinali-Demirci, Selin; Demirci, Serkan; Kurt, Mustafa

    2013-04-01

    The present article deals with the synthesis, spectral characterization and antimicrobial activity of phenylazo dyes. All of the synthesized phenylazo dyes were characterized using ATR-FTIR, FT-Raman, 1H NMR, 13C NMR, elemental analysis and mass spectroscopic techniques. Solvent effects on the UV-Vis absorption spectra of these phenylazo dyes were studied. Acid and base effects on the visible absorption maxima of the phenylazo dyes were also reported. The structural and spectroscopic analysis of the molecules were carried out using Density Functional Theory (DFT) employing the standard 6-31G(d) basis set, and the optimized geometries and calculated vibrational frequencies were evaluated via comparison with experimental values. The antimicrobial activity of 4-(substituted phenylazo)-3,5-diacetamido-1H-pyrazoles was reported against bacteria, including B. cereus (RSKK 863), S. aureus (ATCC 259231), M. luteus (NRRL B-4375), E. coli (ATCC 11230) and the yeast C. albicans (ATCC 10239).

  8. Modulating the Affinities of Phosphopeptides for the Human Pin1 WW Domain Using 4-Substituted Proline Derivatives.

    PubMed

    Huang, Kuei-Yen; Horng, Jia-Cherng

    2015-10-13

    Human Pin1 is involved in cancer developments and has been a pharmaceutical target. Thus, finding a high-affinity inhibitor of Pin1 has become an attractive topic. The WW domain of human Pin1 can recognize the phosphoserine/phosphothreonine-proline (pS/pT-P) motifs, while its PPIase domain catalyzes the cis/trans isomerization of prolyl bonds to regulate the cell cycle. Here we incorporated a series of 4-substituted proline derivatives into the phosphopeptides and investigated their affinities for the WW domain of Pin1 to develop better inhibitors of Pin1. On the basis of the ligand Myt1-T412 [PPA(pT)PP], we synthesized several phosphopeptides in which the proline residue in the pT-P motif was replaced with various 4-substituted proline derivatives. Isothermal titration calorimetry and fluorescence anisotropy analyses show that the replacement of proline with (2S,4R)-4-fluoroproline increases the binding affinity of the peptide. Circular dichroism measurements suggest that a more PPII-like structure of phosphopeptides makes them bind to the WW domain more tightly. Chemical shift perturbation experiments also indicate that (2S,4R)-4-fluoroproline interacts with Trp34 of the WW domain in the binding site. Results of molecular modeling further suggested that a strong C-H···π interaction induced by (2S,4R)-4-fluoroproline is important in enhancing the affinity of the peptide for the WW domain. The results of this study provide new valuable information for designing and developing effective inhibitors of human Pin1.

  9. Influence of Si4+ substitution on the temperature-dependent characteristics of Y3Al5O12:Ce

    NASA Astrophysics Data System (ADS)

    Xu, Sheng-Yan; Zhang, Xiao-Song; Zhou, Yong-Liang; Xi, Qun; Li, Lan

    2011-03-01

    A series of Y3Al5O12:Ce (YAG:Ce) phosphors doped with different Si4+ concentrations is prepared by solid-state reaction. The temperature dependent characteristics of luminescent spectrum and decay time of Ce3+ are investigated. With Si4+ doped, the emission spectrum shows a blue shift due to a decrease of the splitting of 5d levels of Ce3+ ion. The thermal stability is greatly improved by adding Si4+ because the activation energy ΔE increases from 0.1836 eV to 0.2401 eV. The study of the decay times against temperature for various doping concentrations of Si4+ shows that the calculated nonradiative decay rate is affected by Si4+ substitution. The results are explained by the configurational coordinate diagram. Project supported by the National Basic Research Program of China (Grant No. 6139702), the National Natural Science Foundation of China (Grant Nos. 60877029, 60977035 and 60907021), the Natural Science Foundation of the Tianjin Education Committee, China (Grant No. 20071207), and the Natural Science Foundation of Tianjin, China (Grant Nos. 09JCYBJC01400 and 07JCYBJC06400).

  10. In vitro cytotoxic, antibacterial, antifungal and urease inhibitory activities of some N4- substituted isatin-3-thiosemicarbazones.

    PubMed

    Pervez, Humayun; Iqbal, Mohammad S; Tahir, Muhammad Younas; Nasim, Faiz-ul-Hassan; Choudhary, Muhammad Iqbal; Khan, Khalid Mohammed

    2008-12-01

    A series of 15 previously reported N(4)-substituted isatin-3-thiosemicarbazones 3a-o has been screened for cytotoxic, antibacterial, antifungal and urease inhibitory activities. Compounds 3b, 3e and 3n proved to be active in cytotoxicity assay; 3e exhibited a high degree of cytotoxic activity (LD(50) = 1.10 x 10(-5) M). Compound 3h exhibited significant antibacterial activity against B. subtilis, whereas compounds 3a, 3k and 3l displayed significant antifungal activity against one or more fungal strains i.e. T. longifusus, A. flavus and M. canis. In human urease enzyme inhibition assay, compounds 3g, 3k and 3m proved to be the most potent inhibitors, exhibiting relatively pronounced inhibition of the enzyme. These compounds, being non-toxic, could be potential candidates for orally effective therapeutic agents to treat certain clinical conditions induced by bacterial ureases like H. pylori urease. This study presents the first example of inhibition of urease by isatin-thiosemicarbazones and as such provides a solid basis for further research on such compounds to develop more potent inhibitors.

  11. Electron-Rich 4-Substituted Spirobifluorenes: Toward a New Family of High Triplet Energy Host Materials for High-Efficiency Green and Sky Blue Phosphorescent OLEDs.

    PubMed

    Quinton, Cassandre; Thiery, Sébastien; Jeannin, Olivier; Tondelier, Denis; Geffroy, Bernard; Jacques, Emmanuel; Rault-Berthelot, Joëlle; Poriel, Cyril

    2017-02-22

    We report herein a detailed structure-properties relationship study of the first examples of electron-rich 4-substituted spirobifluorenes for organic electronic applications, namely, 4-phenyl-N-carbazole-spirobifluorene (4-PhCz-SBF) and 4-(3,4,5-trimethoxyphenyl)-spirobifluorene (4-Ph(OMe)3-SBF). The incorporation of the electron-rich moieties in the ortho position of the biphenyl linkage (position C4) induces unique properties, very different from those previously described in the literature for this family of semiconductors. Both dyes can be readily synthesized, possess high triplet energies and excellent thermal stability, and their HOMO energy levels are highly increased compared to those of other 4-substituted SBFs. We also provide in this work the first rationalization of the peculiar fluorescence of 4-substituted SBFs. Finally, the present dyes have been successfully incorporated as host in green and blue phosphorescent organic light-emitting diodes with high performance either for the green (EQE of 20.2%) or the blue color (EQE of 9.6%). These performances are, to the best of our knowledge, among the highest reported to date for 4-substituted SBF derivatives.

  12. Synthesis and some pharmacological properties of 3-(piperidin-4-yl)-4-substituted-D2-1,2,4-triazoline-5-thione derivatives.

    PubMed

    Dobosz, Maria; Siwek, Agata; Chodkowska, Anna; Jagiełło-Wójtowicz, Ewa

    2004-12-01

    Synthesis of 3-(piperidin-4-yl)-4-substituted-D-2-1,2,4-triazoline-5-thione derivatives, AS-1-AS-4 is described. Results of a preliminary pharmacological screening of two compounds AS-1 and AS-3 are presented.

  13. Synthesis and anticancer activities of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline derivatives.

    PubMed

    Zhang, Ying; Huang, Yin-Jiu; Xiang, Hong-Mei; Wang, Pei-Yi; Hu, De-Yu; Xue, Wei; Song, Bao-An; Yang, Song

    2014-05-06

    A series of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline was prepared by conventional heating methods. Among these compounds, the crystal structure of compound 10o (CCDC: 916922) was determined by X-ray crystallography. Bioassay results showed that most target compounds had certain inhibition activities against proliferation of tumor cells, and some compounds even had good broad-spectrum inhibition activities. The ethoxyl series of compounds possessed higher inhibition activities against tumor cells than the methoxyl series of compounds. Bioactivity tests showed that the IC50 values of compound 10s against PC3, MGC803, A375, and A549 cells were 1.8, 2.8, 1.3, and 2.9 μΜ, respectively, which were much higher than those of commercial gefitinib (7.2, 7.6, 7.2, and 9.8 μM, respectively). Conversely, the IC50 values of compound 10s were very low against NH3T3, indicating only weak effect on normal cells as also proven by lactate dehydrogenase and acridine orange/ethidium bromide staining. Analyses of cell configuration and cell cycle revealed that compound 10s possibly caused cells to remain at G0/G1 phase by inhibiting cell proliferation for 24 h. Compound 10s also inhibited the phosphorylation of ERK1/2 and P38 with obvious concentration dependence. Thus, these compounds can inhibit the proliferation of A549 cells through the interruption of ERK1/2 and P38signaling pathways. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  14. Electromagnetic and microwave absorption properties of (Co2+-Si4+) substituted barium hexaferrites and its polymer composite

    NASA Astrophysics Data System (ADS)

    Abbas, S. M.; Chatterjee, R.; Dixit, A. K.; Kumar, A. V. R.; Goel, T. C.

    2007-04-01

    The electromagnetic (EM) and microwave absorption properties of (Co2+-Si4+) substituted barium hexaferrite compositions BaCox2+Fey+2Six+y4+Fe12-2x-2y+3O19 (x =0.9 and y =0.0, 0.05, and 0.2) and its polymer composites prepared from hexaferrite, polyaniline, and carbon powders dispersed in polyurethane matrix have been investigated at the microwave frequency range of the X band (8.2-12.4GHz). The hexaferrite compositions were synthesized by solid-state reaction technique, whereas polyaniline, by chemical route. The permeabilities of a ferrite are drastically reduced at higher gigahertz frequencies. The permittivities, however, can be enhanced by appropriate choice of composition and processing temperature. In the present ferrite composition, silicon content is taken in excess so as to convert some of the Fe3+ ions to Fe2+ ions. This conversion has been shown to enhance EM and absorption properties. Mössbauer spectroscopy on the samples establishes that addition of excess Si4+ converts some of the Fe3+ to Fe2+. The sintered ferrites have shown resonance phenomena, but the composites do not. The EM parameters ɛ', ɛ″, μ', and μ″ were measured using a vector network analyzer (Agilent, model PNA E8364B). These measured EM parameters were used to determine the absorption spectra at different sample thicknesses based on a model of a single layered plane wave absorber backed by a perfect conductor. The sintered ferrite composition (x =0.9 and y =0.05) showed the best absorption properties [a minimum reflection loss of -17.7to-14.3dB over the whole frequency range of the X band (8.2-12.4) for a sample thickness of just 0.8mm], and it is used in the composite absorbers in powder form along with other constituents. The optimized composite absorber has shown dielectric constant ɛ'˜11.5, dielectric loss ɛ″˜2.3, and a minimum reflection loss of -29dB at 10.97GHz with the -20dB bandwidth over the frequency range of 9.7-12.2GHz for a sample thickness of 2.0mm. The

  15. Gas chromatography/mass spectrometric study of non-commercial C-4-substituted 1,4-dihydropyridines and their oxidized derivatives.

    PubMed

    López-Alarcón, C; Squella, J A; Núñez-Vergara, Luis J; Baez, H; Camargo, Cristián

    2002-01-01

    A gas chromatography/mass spectrometry (GC/MS) method for the qualitative and quantitative determination of the calcium-channel antagonists C-4-substituted 1,4-dihydropyridines, and their corresponding N-ethyl derivatives, is presented. Also, the electrochemical oxidation and the reactivity of the compounds with alkyl radicals derived from 2,2'-azobis-(2-amidinopropane) were monitored by GC/MS. Mass spectral fragmentation patterns for the C-4-substituted 1,4-dihydropy-ridine parent drugs were significantly different from those of their oxidation products, generated either by electrochemical oxidation or by reaction with alkyl radicals. However, for N-ethyl-1,4-dihydropyridine compounds it was not possible to detect the final products (pyridinium salts) using these experimental conditions. Copyright 2002 John Wiley & Sons, Ltd.

  16. Rhenium and technetium tricarbonyl complexes of 1,4-Substituted pyridyl-1,2,3-triazole bidentate 'click' ligands conjugated to a targeting RGD peptide.

    PubMed

    Connell, Timothy U; Hayne, David J; Ackermann, Uwe; Tochon-Danguy, Henri J; White, Jonathan M; Donnelly, Paul S

    2014-04-01

    New 1,4-substituted pyridyl-1,2,3-triazole ligands with pendent phenyl isothiocyanate functional groups linked to the heterocycle through a short methylene or longer polyethylene glycol spacers were prepared and conjugated to a peptide containing the arginine-glycine-aspartic acid peptide motif. Rhenium and technetium carbonyl complexes, [M(CO)3 L(x) (py)](+) (where M = Re(I) or (99m) Tc(I) ; L(x)  = 1,4-substituted pyridyl-1,2,3-triazole ligands and py = pyridine) were prepared. One rhenium complex has been characterized by X-ray crystallography, and the luminescent properties of [M(CO)3 L(x) (py)](+) are reported.

  17. Ultrasound-mediated synthesis of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates catalyzed by 1-carboxymethyl-3-methylimidazolium tetrafluoroborate under solvent free condition.

    PubMed

    He, Jing-Yu; Jia, Hui-Zhen; Yao, Qing-Guo; Liu, Si-Jie; Yue, Hong-Kun; Yu, Hong-Wei; Hu, Rui-Sheng

    2015-01-01

    4-Substituted 1,4-dihydropyridine-3,5-dicarboxylates (4) have been synthesized by the solvent-free reaction of aldehyde, methyl propiolate and ammonium carbonate catalyzed by ionic liquid 1-carboxymethyl-3-methylimidazolium tetrafluoroborate under ultrasonic irradiation. The effects of changes in the ultrasonic power, temperature, catalysts and reactants on the synthesis of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates (4) are discussed. With the optimized reaction conditions, various aldehydes were used to synthesize 1,4-dihydropyridines (4) under the influence of ultrasound irradiation. Compared with the conventional thermal methods, the remarkable advantages of this method are the simple experimental procedure, shorter reaction time (2-10min) and high yield of product (76-95%). Furthermore, the green catalytic system can be recycled specific times without significantly decreasing the yields and reaction rates.

  18. Stereoselective Synthesis of 4-Substituted Cyclic Sulfamidate-5-Phosphonates by Using Rh-Catalyzed, Asymmetric Transfer Hydrogenation with Accompanying Dynamic Kinetic Resolution.

    PubMed

    Seo, Yeon Ji; Kim, Jin-ah; Lee, Hyeon-Kyu

    2015-09-04

    Dynamic kinetic resolution driven, asymmetric transfer hydrogenation of 4-substituted cyclic sulfamidate imine-5-phosphonates produces the corresponding cyclic sulfamidate-5-phosphonates. The process employs a HCO2H/Et3N mixture as the hydrogen source and the chiral Rh catalysts, (R,R)- or (S,S)-Cp*RhCl(TsDPEN), and it takes place at room temperature within 1 h with high yields and high levels of stereoselectivity.

  19. FeCl3-catalysed ultrasonic-assisted, solvent-free synthesis of 4-substituted coumarins. A useful complement to the Pechmann reaction.

    PubMed

    Prousis, Kyriakos C; Avlonitis, Nicolaos; Heropoulos, Georgios A; Calogeropoulou, Theodora

    2014-05-01

    The catalytic activity of FeCl3 for the synthesis of a variety of 4-substituted coumarins using high energy techniques has been investigated. The ultrasonic-assisted conditions provide a useful complement to the Pechmann reaction, affording the coumarin derivatives in excellent yields, under solvent-free conditions, in short reaction times using an inexpensive, mild and benign Lewis acid catalyst. Copyright © 2013 Elsevier B.V. All rights reserved.

  20. Search for possible CNS depressant compounds: Part II. Synthesis of some new 1-(2'-methoxy-4'-nitrophenyl)-2-phenyl-4-substituted arylidene-5-imidazolones as CNS depressants.

    PubMed

    Mukerji, D D; Nautiyal, S R; Prasad, C R

    1981-01-01

    Some new 1-(2'-methoxy-4'-nitrophenyl)-2-phenyl-4-substituted benzylidene, furylidene and naphthylidene-5-imidazolones have been synthesized and tested on their CNS. anticonvulsant and analgesic activities in albino mice. At a dose of 200 mg/kg they displayed CNS depressant properties producing ataxia, decrease in spontaneous motor activity and loss of righting reflex. They also exhibited mild anticonvulsant activity in the pentetrazol test.

  1. [Synthesis of 4-substituted 17 beta-hydroxy-7 alpha-methyl-4-estren-3-one and their 17-acetates as antifertility compounds].

    PubMed

    Ma, J B; Li, Z S

    1990-01-01

    Guided by antiprogestational screening results, 4-substituted(4-OH, 4-Cl, 4-Br, and 4-OMe) 17 beta-hydroxy-7 alpha-methyl-4-estren-3-one and their 17-acetate were synthesized via 4 beta, 5 beta-epoxy-17 beta-hydroxy-7 alpha-methylestran-3-one from 17 beta-hydroxy-7 alpha-methyl-4-estren-3-one. Some of these compounds possess strong affinity to human decidual progesterone receptor, inhibit in vitro the growth of decidual cells, and prevent the implantation in rats at the dose of 1 mumol/kg.

  2. Synthesis and preliminary screening of novel N-{2-[4-(substituted)piperazin-1-yl]-2-oxoethyl}acetamides as potential atypical antipsychotic agents.

    PubMed

    Chandra Sekhar, Kondapalli Venkata Gowri; Rao, Vajja Samabasiva; Krishna, Mutyala Murali

    2009-06-01

    A series of N-{2-[4-(substituted)piperazin-1-yl]-2-oxoethyl}acetamides were synthesized as prospective novel atypical antipsychotic agents. Microwave irradiation of acetyl glycine (I) with substituted piperazines in the presence of DCC in DMF for about 3-5 min gave the titled compounds (P:1-7). All the synthesized compounds were screened for their in vivo pharmacological activity in Swiss albino mice. D(2) antagonism studies were performed using the climbing mouse assay model and 5-HT(2A) antagonism studies were performed using quipazine induced head twitches in mice. Among the synthesized compounds P4 was found to be the most active compound.

  3. Tricarbonylrhenium complexes from 2-pyridyl-1,2,3-triazole ligands bearing a 4-substituted phenyl arm: a combined experimental and theoretical study.

    PubMed

    Wolff, Mariusz; Munoz, Luc; François, Alison; Carrayon, Chantal; Seridi, Achour; Saffon, Nathalie; Picard, Claude; Machura, Barbara; Benoist, Eric

    2013-05-21

    Three new pyridyltriazole ligands (named pyta) bearing a 4-substituted phenyl arm (nitro- (2a), chloro- (2b) or aminophenyl (2c) moiety) have been synthesized using a convenient click chemistry strategy. The corresponding tricarbonylrhenium complexes 3a, 3b and 3c were prepared and fully characterized by means of NMR, IR and mass spectrometry, as well as X-ray crystallography for two of them (3a and 3b). The direct connection of a 4-substituted phenyl arm at the N1 position of the triazolyl ring has a significant influence on the geometry of both, the ligands and their corresponding Re-complexes. The dominant structural feature of these complexes concerns the crystal cohesion. Slip-stacked π-π interactions between two molecules of the complex were observed for 3a and 3b probably resulting from the co-planarity of the organic framework. Furthermore, a combined experimental study and DFT calculations showed that the nature of the pendant arm (X = NO2, NH2 or Cl) could affect the electronic properties of the Re-complexes. If the chloro- or aminophenyl moieties unmodified the photo-physical properties of the complexes 3b and 3c, the presence of a nitrophenyl arm for the complex 3a quenched the luminescence, due to a high probability of non-radiative deactivation.

  4. Synthesis and trypanocidal activity of a library of 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols.

    PubMed

    Balfour, Michael N; Franco, Caio H; Moraes, Carolina B; Freitas-Junior, Lucio H; Stefani, Hélio A

    2017-03-10

    A library of 16 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols 17-32 has been synthesized for use in biological testing against Trypanosoma cruzi, the protozoan parasite that causes Chagas disease. The 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols 17-32 were subjected to biological testing to evaluate their efficacy against intracellular Trypanosoma cruzi (Y strain) amastigotes infecting U2OS human cells, with benznidazole as a reference compound. The assay was performed in duplicate (two independent experiments) and submitted to High Content Analysis (HCA) for determination of trypanocidal activity. Three of the tested compounds presented relatively high trypanocidal activity (19, 22 and 29), however severe host cell toxicity was observed concomitantly. Chemical optimization of the highly active compounds and the synthesis of more compounds for biological testing against Trypanosoma cruzi will be required to improve selectivity and so that a structure-activity relationship can be generated to provide a more insightful analysis of both chemical and biological aspects.

  5. Antimicrobial screening and one-pot synthesis of 4-(substituted-anilinomethyl)-3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives

    PubMed Central

    Goel, Neelima; Drabu, Sushma; Afzal, Obaid; Bawa, Sandhya

    2014-01-01

    Aim: Synthesis of series of 4-(substituted-anilinomethyl-3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives (4a–4k) and their in vitro antifungal and antibacterial screening. Materials and Methods: A series of compounds (4a–4k) was synthesized through direct reductive amination of 3-(naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde with various substituted aromatic amines using NaBH4 in the presence of I2 as reducing agent. The reaction was carried out in anhydrous methanol under neutral conditions at room temperature. The structures of synthesized compounds (4a–4k) were established on the basis of IR, 1H and 13C-NMR, and mass spectral data. Results: All 4-(substituted-anilinomethyl-3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives (4a–4k) were tested in vitro for antifungal and antibacterial activities against different fungal and bacterial strains. Most of the compounds exhibited considerable antifungal activity, but poor antibacterial activity against the test strains. Conclusion: In the series compound 4e, 4g, 4j, and 4k, showed excellent antifungal activity against the fungal strain Aspergillus niger (MTCC) 281 and Aspergillus flavus MTCC 277 (% inhibition in the range of 47.7–58.9). PMID:25400408

  6. Scope Processing in Chinese

    ERIC Educational Resources Information Center

    Zhou, Peng; Gao, Liqun

    2009-01-01

    The standard view maintains that quantifier scope interpretation results from an interaction between different modules: the syntax, the semantics as well as the pragmatics. Thus, by examining the mechanism of quantifier scope interpretation, we will certainly gain some insight into how these different modules interact with one another. To observe…

  7. 4-Substituted 4-(1H-1,2,3-triazol-1-yl)piperidine: novel C7 moieties of fluoroquinolones as antibacterial agents.

    PubMed

    Huang, Xiaoguang; Zhang, Aiqin; Chen, Dongliang; Jia, Zhenhua; Li, Xingshu

    2010-05-01

    A series of 4-substituted 4-(1H-1,2,3-triazol-1-yl)piperidine building blocks was synthesized and introduced to the C7 position of the quinolone core, 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid, to afford the corresponding fluoroquinolones in 40-83% yield. The antibacterial activity of these new fluoroquinolones was evaluated using a standard broth microdilution technique. Among them, the quinolone 1-cyclopropyl-6-fluoro-7-(4-(4-formyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (34.15) exhibited comparable antibacterial activity against quinolone-susceptible and multidrug-resistant strains, especially to Staphylococcus aureus and Staphylococcus epidermidis, in comparison with ciprofloxacin and vancomycin. 2010 Elsevier Ltd. All rights reserved.

  8. Design, synthesis, pharmacological evaluation and descriptor based similarities study of N,N-diphenyl-2-[4-(substituted phenyl)piperazin-1-yl]acetamides as potential antipsychotics.

    PubMed

    Dash, Radha Charan; Bhosale, Sharad H; Shelke, Suhas M; Suryawanshi, Mugdha R; Mahadik, Kakasaheb R

    2012-11-01

    A series of novel N,N-diphenyl-2-[4-(substituted phenyl)piperazin-1-yl]acetamides was designed, synthesized and evaluated for anti-dopaminergic activity, anti-serotonergic activity and catalepsy induction studies in mice as an approach to novel potential antipsychotic agent. Antipsychotic activity of these compounds in terms of blocking of dopaminergic transmission was evaluated by their ability to inhibit apomorphine induced climbing behavior in mice and antiserotonergic activity of synthesized compounds was assessed by studying inhibition of 5-HTP induced head twitches. All the synthesized compounds were found to exhibit anti-dopaminergic and anti-serotonergic activity in behavioral models. The compound 3f showed better antipsychotic potential among the different synthesized compounds. The descriptor based similarities study for blood brain permeation established a good similarity between the synthesized compounds with standard atypical antipsychotics.

  9. Spectroscopic and X-ray crystallographic evidence for electrostatic effects in 4-substituted cyclohexanone-derived hydrazones, imines, and corresponding salts.

    PubMed

    Dibble, David J; Ziller, Joseph W; Woerpel, K A

    2011-10-07

    The axial conformer of several 4-substituted cyclohexanone hydrazone salts was found to predominate in solution. Changes in the charge of the molecule and the polarity of the solvent led to changes in the conformational preference of each molecule that were consistent with electrostatic stabilization of the axial conformer. (1)H NMR spectroscopic analysis was utilized to determine the structure of cyclohexanone-derived substrates by comparison to conformationally restricted trans-decalone derivatives and computational models. X-ray crystallography demonstrated that the axial configuration of a pendant benzyloxy group is the preferred conformation of an iminium ion in the solid state. The structure of a neutral hydrazone was also determined to favor the axial configuration for a pendant benzyloxy group in the solid state.

  10. 4-Substituted-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives: design, synthesis, antitumor and EGFR tyrosine kinase inhibitory activity.

    PubMed

    Abbas, Safinaz E-S; Aly, Enayat I; Awadallah, Fadi M; Mahmoud, Walaa R

    2015-05-01

    Four series of some 4-substituted-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives 5a-f, 6a-f, 8a-f, and 9a-f were designed to be screened for their antitumor activity. All compounds were evaluated against breast (MCF-7) and lung (A-549) cell lines. Six compounds 5a, 5b, 6b, 6e, 9e, and 9f displaying activity against both cell lines were further estimated for their EGFR-TK inhibitory activity where they revealed 41-91% inhibition and compound 6b elicited the highest activity (91%). A docking study of these compounds into the ATP-binding site of EGFR-TK demonstrated their binding mode where H-bonding interaction with Met793 through N(1) of pyrimidine or N(2) of pyrazole was observed. © 2014 John Wiley & Sons A/S.

  11. Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors.

    PubMed

    Zhang, Zhen; Zhao, Dongmei; Dai, Yang; Cheng, Maosheng; Geng, Meiyu; Shen, Jingkang; Ma, Yuchi; Ai, Jing; Xiong, Bing

    2016-10-23

    Tyrosine kinase fibroblast growth factor receptor (FGFR), which is aberrant in various cancer types, is a promising target for cancer therapy. Here we reported the design, synthesis, and biological evaluation of a new series of 6-(2,6-dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazole derivatives as potent FGFR inhibitors. The compound 6-(2,6-dichloro-3,5-dimethoxyphenyl)-N-phenyl-1H-indazole-4-carboxamide (10a) was identified as a potent FGFR1 inhibitor, with good enzymatic inhibition. Further structure-based optimization revealed that 6-(2,6-dichloro-3,5-dimethoxyphenyl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-indazole-4-carboxamide (13a) is the most potent FGFR1 inhibitor in this series, with an enzyme inhibitory activity IC50 value of about 30.2 nM.

  12. Chromobacterium violaceum ω-transaminase variant Trp60Cys shows increased specificity for (S)-1-phenylethylamine and 4'-substituted acetophenones, and follows Swain-Lupton parameterisation.

    PubMed

    Cassimjee, Karim Engelmark; Humble, Maria Svedendahl; Land, Henrik; Abedi, Vahak; Berglund, Per

    2012-07-28

    For biocatalytic production of pharmaceutically important chiral amines the ω-transaminase enzymes have proven useful. Engineering of these enzymes has to some extent been accomplished by rational design, but mostly by directed evolution. By use of a homology model a key point mutation in Chromobacterium violaceum ω-transaminase was found upon comparison with engineered variants from homologous enzymes. The variant Trp60Cys gave increased specificity for (S)-1-phenylethylamine (29-fold) and 4'-substituted acetophenones (∼5-fold). To further study the effect of the mutation the reaction rates were Swain-Lupton parameterised. On comparison with the wild type, reactions of the variant showed increased resonance dependence; this observation together with changed pH optimum and cofactor dependence suggests an altered reaction mechanism.

  13. Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.

    PubMed

    Secci, Daniela; Bolasco, Adriana; Carradori, Simone; D'Ascenzio, Melissa; Nescatelli, Riccardo; Yáñez, Matilde

    2012-12-01

    A large series of (4-substituted-thiazol-2-yl)hydrazine derivatives was synthesized in good yield and assayed for their in vitro human monoamine oxidase (hMAO) inhibitory activity and selectivity. Most of them showed inhibitory activity in the nanomolar range and hMAO-B selective inhibition higher than reference drugs, demonstrating our interest in this privileged scaffold. The structure-activity relationship of the different rings on the N1-hydrazine position indicated that a pyridine ring was preferred with the presence of electron-withdrawing substituents on the aryl group at C4 of the thiazole nucleus. The substituent on the α-carbon to the N1-hydrazine moiety (methyl or hydrogen) had a great influence on the activity and hMAO-B selectivity. Moreover, the reversibility of the enzyme inhibition for the best active compound was reported.

  14. Synthesis and antitubercular activity of novel 4-substituted imidazolyl-2,6-dimethyl-N3,N5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides.

    PubMed

    Fassihi, Afshin; Azadpour, Zahra; Delbari, Neda; Saghaie, Lotfollah; Memarian, Hamid R; Sabet, Razieh; Alborzi, Abdolvahab; Miri, Ramin; Pourabbas, Bahman; Mardaneh, Jalal; Mousavi, Pegah; Moeinifard, Behzad; Sadeghi-Aliabadi, Hojjat

    2009-08-01

    A series of 4-substituted imidazolyl-2,6-dimethyl-N(3),N(5)-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides were prepared. They were screened as antitubercular agents against Mycobacterium tuberculosis H(37)Rv. Minimum inhibitory concentrations (MICs) were determined using agar proportion method. Compound 3i with 1-benzyl-2-methylthio-1H-imidazole-5-yl substituent at C-4 position and 4'-chloromophenyl group at C-3 and C-5 positions of the 1,4-dihydropyridine ring was the most potent one among the tested compounds. It was as potent as rifampicin against M. tuberculosis H(37)RV. Compound 3l also was an active antitubercular agent with the same substituent as compound 3i at the C-4 position and 3'-pyridyl group at C-3 and C-5 positions of the 1,4-dihydropyridine ring.

  15. Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity

    PubMed Central

    Chen, Yi-Fong; Lin, Yi-Chien; Morris-Natschke, Susan L; Wei, Chen-Fang; Shen, Ting-Chen; Lin, Hui-Yi; Hsu, Mei-Hua; Chou, Li-Chen; Zhao, Yu; Kuo, Sheng-Chu; Lee, Kuo-Hsiung; Huang, Li-Jiau

    2015-01-01

    Background and Purpose 4-Phenylquinolin-2(1H)-one (4-PQ) derivatives can induce cancer cell apoptosis. Additional new 4-PQ analogs were investigated as more effective, less toxic antitumour agents. Experimental Approach Forty-five 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives were synthesized. Antiproliferative activities were evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliun bromide assay and structure–activity relationship correlations were established. Compounds 9b, 9c, 9e and 11e were also evaluated against the National Cancer Institute-60 human cancer cell line panel. Hoechst 33258 and Annexin V-FITC/PI staining assays were used to detect apoptosis, while inhibition of microtubule polymerization was assayed by fluorescence microscopy. Effects on the cell cycle were assessed by flow cytometry and on apoptosis-related proteins (active caspase-3, -8 and -9, procaspase-3, -8, -9, PARP, Bid, Bcl-xL and Bcl-2) by Western blotting. Key Results Nine 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives (7e, 8e, 9b, 9c, 9e, 10c, 10e, 11c and 11e) displayed high potency against HL-60, Hep3B, H460, and COLO 205 cancer cells (IC50 < 1 μM) without affecting Detroit 551 normal human cells (IC50 > 50 μM). Particularly, compound 11e exhibited nanomolar potency against COLO 205 cancer cells. Mechanistic studies indicated that compound 11e disrupted microtubule assembly and induced G2/M arrest, polyploidy and apoptosis via the intrinsic and extrinsic signalling pathways. Activation of JNK could play a role in TRAIL-induced COLO 205 apoptosis. Conclusion and Implications New quinolone derivatives were identified as potential pro-apoptotic agents. Compound 11e could be a promising lead compound for future antitumour agent development. PMID:25363404

  16. Synthesis and antidepressant activities of 4-(substituted-phenyl)tetrazolo[1,5-a]quinazolin-5(4H)-ones and their derivatives.

    PubMed

    Zhang, Hong-Jian; Wang, Shi-Ben; Quan, Zhe-Shan

    2015-11-01

    A series of novel 4-(substituted-phenyl) tetrazolo[1,5-a]quinazolin-5(4H)-ones (6a-x) and their derivatives with tetrazole and other heterocyclic substituents (7-14) were designed, synthesized, and evaluated for antidepressant activities in mice. Pharmacological tests showed that three compounds (6l, 6u, and 6v) at a dose of 50 mg/kg significantly reduced the immobility time in the forced swimming test. The most active compound was 4-(p-tolyl)tetrazolo[1,5-a]quinazolin-5(4H)-one (6v), which decreased the immobility time by 82.69 % at 50 mg/kg. Moreover, 6v did not affect spontaneous activity in the open-field test, and this effect was comparable to the antidepressant effect of fluoxetine. Noradrenaline (NE) and 5-hydroxytryptamine (5-HT) levels in the brains of mice in the test sample groups significantly increased at a dose of 50 mg/kg compared with that in the control group. The monoamine oxidase (MAO) level of all test groups was reduced, but this result was not significantly different between the groups. Therefore, we can infer that their underlying mechanisms may involve the regulation of brain monoamine neurotransmitter homeostasis, based on the detected content of NE, 5-HT, and MAO in mouse brain tissue.

  17. Novel 4-substituted phenyl-2,2′-bichalcophenes and aza-analogs as antibacterial agents: a structural activity relationship

    PubMed Central

    Hussin, Warda A; Ismail, Mohamed A; El-Sayed, Wael M

    2013-01-01

    Antibiotic resistance is a major health problem; therefore, new antibacterial agents will need to be continuously developed. A series of novel bichalcophenes has been tested and found to have antimicrobial activity against selected bacteria. Due to the promising antimicrobial effects of these 4-substituted phenyl bichalcophene derivatives, the study reported here was launched to examine the interaction between novel bichalcophenes and tetracycline. The minimum inhibitory concentration values for all bichalcophenes were between 8 and 64 μM. Many of the bichalcophenes had synergistic activity that increased the inhibitory effect of tetracycline against bacterial growth, as indicated by the fractional inhibitory concentration index. The post-antibiotic effects of the novel bichalcophenes were determined. Many bichalcophenes were able to elongate the period required for bacteria to recover and grow after a brief exposure to tetracycline. Escherichia coli did not develop resistance to many bichalcophenes over a period of 7 days. A structural activity relationship could be characterized, as monocationic derivatives were more active than the corresponding mononitriles. The presence of a pyridyl group and/or furan ring reduced the activity, while the presence of a phenyl or thiophene ring enhanced the antibacterial activity. Our results suggest that bichalcophenes could be useful to elevate the shelf life of many antibiotics. PMID:23662048

  18. Spectroscopy and quantum-chemical calculations of nitro-bis-bipyridyl complexes of ruthenium(II) with 4-substituted pyridine ligands

    NASA Astrophysics Data System (ADS)

    Reshetova, K. I.; Krauklis, I. V.; Litke, S. V.; Ershov, A. Yu.; Chizhov, Yu. V.

    2016-04-01

    The luminescence, absorption, and luminescence excitation spectra of complexes cis-[Ru(bpy)2(L)(NO2)]+ [bpy = 2,2'-bipyridyl, L = pyridine, 4-aminopyridine, 4-dimethylaminopyridine, 4-picoline, isonicotinamide, or 4,4'-bipyridyl] in alcoholic (4 : 1 EtOH-MeOH) solutions are studied at 77 K. A linear correlation is established between the energy of the lowest electronically excited metal-toligand charge transfer state d π(Ru) → π*(bpy) of the complexes and the pKa parameter of the free 4-substituted pyridines used as ligands L. The B3LYP/[6-31G(d)+LanL2DZ(Ru)] hybrid density functional method is used to optimize the geometry of complexes and calculate their electronic structure and the charge distribution on the atoms of the nearest environment of ruthenium(II) ions. It is shown that there exists a mutually unambiguous correspondence between the charge on the nitrogen atom of ligands L coordinated in the complex and the pK a parameter of ligands. The calculated energies of the electronically excited metal-to-ligand charge transfer states of complexes linearly (correlation coefficient 0.99) depend on the charge on the nitrogen atom of ligands L, which completely agrees with the experimental data.

  19. Mononuclear zinc(II) complexes of 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols: Synthesis, structural characterization, DNA binding and cheminuclease activities

    NASA Astrophysics Data System (ADS)

    Ravichandran, J.; Gurumoorthy, P.; Karthick, C.; Kalilur Rahiman, A.

    2014-03-01

    Four new zinc(II) complexes [Zn(HL1-4)Cl2] (1-4), where HL1-4 = 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols, have been isolated and fully characterized using various spectro-analytical techniques. The X-ray crystal structure of complex 4 shows the distorted trigonal-bipyramidal coordination geometry around zinc(II) ion. The crystal packing is stabilized by intermolecular NH⋯O hydrogen bonding interaction. The complexes display no d-d electronic band in the visible region due to d10 electronic configuration of zinc(II) ion. The electrochemical properties of the synthesized ligands and their complexes exhibit similar voltammogram at reduction potential due to electrochemically innocent Zn(II) ion, which evidenced that the electron transfer is due to the nature of the ligand. Binding interaction of complexes with calf thymus DNA was studied by UV-Vis absorption titration, viscometric titration and cyclic voltammetry. All complexes bind with CT DNA by intercalation, giving the binding affinity in the order of 2 > 1 ≫ 3 > 4. The prominent cheminuclease activity of complexes on plasmid DNA (pBR322 DNA) was observed in the absence and presence of H2O2. Oxidative pathway reveals that the underlying mechanism involves hydroxyl radical.

  20. Antioxidant, DNA binding and nuclease activities of heteroleptic copper(II) complexes derived from 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols and diimines

    NASA Astrophysics Data System (ADS)

    Ravichandran, J.; Gurumoorthy, P.; Imran Musthafa, M. A.; Kalilur Rahiman, A.

    2014-12-01

    A series of heteroleptic copper(II) complexes of the type [CuL1-4(diimine)](ClO4)2 (1-8) [L1-4 = 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols, and diimine = 2,2‧-bipyridyl (bpy) or 1,10-phenanthroline (phen)], have been synthesized and characterized by spectroscopic methods. The IR spectra of complexes indicate the presence of uncoordinated perchlorate anions and the electronic spectra revealed the square pyramidal geometry with N4O coordination environment around copper(II) nuclei. Electrochemical studies of the mononuclear complexes evidenced one-electron irreversible reduction wave in the cathodic region. The EPR spectra of complexes with g|| (2.206-2.214) and A|| (154-172 × 10-4 cm-1) values support the square-based CuN3O coordination chromophore and the presence of unpaired electron localized in dx-y ground state. Antioxidant studies against DPPH revealed effective radical scavenging properties of the synthesized complexes. Binding studies suggest that the heteroleptic copper(II) complexes interact with calf thymus DNA (CT-DNA) through minor-groove and electrostatic interaction, and all the complexes display pronounced nuclease activity against supercoiled pBR322 DNA.

  1. ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones as potential anti- Trypanosoma cruzi agents

    NASA Astrophysics Data System (ADS)

    Aguilera-Venegas, Benjamín; Olea-Azar, Claudio; Norambuena, Ester; Arán, Vicente J.; Mendizábal, Fernando; Lapier, Michel; Maya, Juan Diego; Kemmerling, Ulrike; López-Muñoz, Rodrigo

    2011-03-01

    Electrochemical and ESR studies were carried out in this work with the aim of characterizing the reduction mechanisms of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones by means of cyclic voltammetry in DMSO as aprotic solvent. Two reduction mechanisms were found for these compounds: the first, for compounds bearing a labile hydrogen by following a self-protonation mechanism (ECE steps), and the second, for compounds without labile hydrogen, based on a purely electrochemical reduction mechanism (typical of nitroheterocycles). The electrochemical results were corroborated using ESR spectroscopy allowing us to propose the hyperfine splitting pattern of the nitro-radical, which was later corroborated by the ESR simulation spectra. All these compounds were assayed as growth inhibitors against Trypanosoma cruzi: first, on the non-proliferative (and infective) form of the parasite (trypomastigote stage), and then, the ones that displayed activity, were assayed on the non-infective form (epimastigote stage). Thus, we found four new compounds highly active against T. cruzi. Finally, molecular modeling studies suggest the inhibition of the trypanothione reductase like one of the possible mechanisms involved in the trypanocidal action.

  2. Separation optimization of aniline and seven 4-substituted anilines in high-submicellar liquid chromatography using empirical retention modeling and Derringer's desirability function.

    PubMed

    Hadjmohammadi, Mohammad Reza; S J Nazari, S Saman

    2013-08-01

    The separation optimization of aniline and seven 4-substituted derivatives in high-submicellar LC was performed using an interpretive optimization strategy and Derringer's desirability function. Description of the retention of solutes was carried out through several hyperbolic and logarithmic retention models using the retention data of five mobile phases of SDS (0.06-0.12 M) and methanol (50-70% v/v) at pH 3. Among the investigated models, a logarithmic retention model logk=c0+c1φ+c2[S]+c12φ[S]+d12(φ[S])0.5 showed the best prediction capability and was used to predict the solute retention factors. A grid search program was used to calculate the retention times of each solute, based on the best retention model, for all combinations of SDS and methanol concentrations in the factor space. Two different chromatographic goals, analysis time and retention differences between adjacent peaks, were evaluated simultaneously using Derringer's desirability function for each mobile phase conditions in the grid search. Optimal mobile phase composition for separation of eight anilines was found to be 0.119 M SDS and 53% v/v methanol. Under these conditions, full resolutions with a reasonable analysis time (22 min) were obtained. At the optimal condition, a good agreement was observed between predicted and experimental values of the retention times.

  3. Direct Functionalization of an Acid-Terminated Nanodiamond with Azide: Enabling Access to 4-Substituted-1,2,3-Triazole-Functionalized Particles

    DOE PAGES

    Kennedy, Zachary C.; Barrett, Christopher A.; Warner, Marvin G.

    2017-03-01

    Azides on the periphery of nanodiamond materials (ND) are of great utility because they have been shown to undergo Cu-catalyzed and Cu-free cycloaddition reactions with structurally diverse alkynes, affording particles tailored for applications in biology and materials science. However, current methods employed to access ND featuring azide groups typically require either harsh pretreatment procedures or multiple synthesis steps and use surface linking groups that may be susceptible to undesirable cleavage. Here in this paper we demonstrate an alternative single-step approach to producing linker-free, azide-functionalized ND. Our method was applied to low-cost, detonation-derived ND powders where surface carbonyl groups undergo silver-mediatedmore » decarboxylation and radical substitution with azide. ND with directly grafted azide groups were then treated with a variety of aliphatic, aromatic, and fluorescent alkynes to afford 1-(ND)-4-substituted-1,2,3-triazole materials under standard copper-catalyzed cycloaddition conditions. Surface modification steps were verified by characteristic infrared absorptions and elemental analyses. High loadings of triazole surface groups (up to 0.85 mmol g–1) were obtained as determined from thermogravimetric analysis. The azidation procedure disclosed is envisioned to become a valuable initial transformation in numerous future applications of ND.« less

  4. Spectroscopic and quantum-chemical investigations of chloro-bis-bipyridyl complexes of ruthenium(II) with 4-substituted pyridine ligands

    NASA Astrophysics Data System (ADS)

    Reshetova, K. I.; Krauklis, I. V.; Litke, S. V.; Ershov, A. Yu.

    2014-07-01

    The luminescence spectra of cis-[Ru(bpy)2(L)Cl]+ (bpy is 2,2'-bipyridyl; L is pyrazine, pyridine, 4-amino-pyridine, 4-picolin, isonicotinamide, 4-cyanopyridine, or 4,4'bipyridyl) complexes are studied in alcoholic (4: 1 EtOH-MeOH) solutions at 77 K. A linear correlation is found between the energy of the lowest electronically excited metal-to-ligand charge transfer (3MLCT) state d π(Ru) → π* (bpy) and the parameter p K a of the free 4-substituted pyridines and pyrazine used as ligands L. The [B3LYP/6-31G + LanL2DZ(Ru)] hybrid method of the density functional theory is used to optimize the geometry of complexes and calculate their electronic structure and the charge distribution on the atoms of the nearest environment of the ruthenium ion. It is shown that there exists a linear unambiguous correlation between the negative charge on the nitrogen atom ( qN L) of ligands L coordinated in the complex and the parameters p K a of free ligands. The calculated energies of 3MLCT excited states almost linearly (correlation coefficient 0.958) depend on the charge qN L, which completely agrees with experimental data.

  5. Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.

    PubMed

    Høg, Signe; Wellendorph, Petrine; Nielsen, Birgitte; Frydenvang, Karla; Dahl, Ivar F; Bräuner-Osborne, Hans; Brehm, Lotte; Frølund, Bente; Clausen, Rasmus P

    2008-12-25

    Gamma-hydroxybutyrate (GHB) is a metabolite of gamma-aminobutyric acid (GABA) and has been proposed to function as a neurotransmitter or neuromodulator. GHB is used in the treatment of narcolepsy and is a drug of abuse. GHB binds to both GABA(B) receptors and specific high-affinity GHB sites in brain, of which the latter have not been linked unequivocally to function, but are speculated to be GHB receptors. In this study, a series of biaromatic 4-substituted GHB analogues, including 4'-phenethylphenyl, 4'-styrylphenyl, and 4'-benzyloxyphenyl GHB analogues, were synthesized and characterized pharmacologically in a [3H](E,RS)-(6,7,8,9-tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylidene)acetic acid ([3H]NCS-382) binding assay and in GABA(A) and GABA(B) receptor binding assays. The compounds were selective for the high-affinity GHB binding sites and several displayed Ki values below 100 nM. The affinity of the 4-[4'-(2-iodobenzyloxy)phenyl] GHB analogue 17b was shown to reside predominantly with the R-enantiomer (Ki = 22 nM), which has higher affinity than previously reported GHB ligands.

  6. Synthesis and Antiproliferative Effect of Ethyl 4-[4-(4-Substituted Piperidin-1-yl)]benzylpyrrolo[1,2-a]quinoxalinecarboxylate Derivatives on Human Leukemia Cells.

    PubMed

    Desplat, Vanessa; Vincenzi, Marian; Lucas, Romain; Moreau, Stéphane; Savrimoutou, Solène; Rubio, Sandra; Pinaud, Noël; Bigat, David; Enriquez, Elodie; Marchivie, Mathieu; Routier, Sylvain; Sonnet, Pascal; Rossi, Filomena; Ronga, Luisa; Guillon, Jean

    2017-02-20

    Acute leukemia is a hematological malignancy with high incidence and recurrence rates and is characterized by an accumulation of blasts in bone marrow due to proliferation of immature lymphoid or myeloid cells associated with a blockade of differentiation. The heterogeneity of leukemia led us to look for new specific molecules for leukemia subtypes or for therapy-resistant cases. Among heterocyclic derivatives that attracted attention due to their wide range of biological activities, we focused our interest on the pyrrolo[1,2-a]quinoxaline heterocyclic framework that has been previously identified as an interesting scaffold for antiproliferative activities against various human cancer cell lines. In this work, new ethyl 4-[4-(4-substituted piperidin-1-yl)]benzylpyrrolo[1,2-a]quinoxalinecarboxylate derivatives (1 a-o) were designed, synthesized, and evaluated against five different leukemia cell lines, including Jurkat and U266 (lymphoid cell lines) and K562, U937, and HL60 (myeloid cell lines), as well as on normal human peripheral blood mononuclear cells (PBMCs). This new pyrrolo[1,2-a]quinoxaline series showed interesting cytotoxic potential against all tested leukemia cell lines. In particular, pyrroloquinoxalines 1 a and 1 m,n seem to be interesting due to their high activity against leukemia and their low activity against normal hematopoietic cells, leading to a high index of selectivity.

  7. Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies.

    PubMed

    Abdel-Aziz, Alaa A-M; El-Azab, Adel S; Alanazi, Amer M; Asiri, Yousif A; Al-Suwaidan, Ibrahim A; Maarouf, Azza R; Ayyad, Rezk R; Shawer, Taghreed Z

    2016-10-01

    The potential antitumor activities of a series of 7-(4-substituted piperazin-1-yl)fluoroquinolone derivatives (1-14a,b) using ciprofloxacin and norfloxacin as scaffolds are described. These compounds exhibit potent and broad spectrum antitumor activities using 60 human cell lines in addition to the inherent antibacterial activity. Compounds 1a, 2a, 3b, 6b and 7a were found to be the most potent, while 2b, 5b, and 6a were found to have an average activity. The results of this study demonstrated that compounds 1a, 2a, 3b, 6b and 7a (mean GI50; 2.63-3.09 µM) are nearly 7-fold more potent compared with the positive control 5-fluorouracil (mean GI50; 22.60 µM). More interestingly, compounds 1a, 2a, 3b, 6b and 7a have an almost antitumor activity similar to gefitinib (mean GI50; 3.24 µM) and are nearly 2-fold more potent compared to erlotinib (mean GI50; 7.29 µM). In silico study and ADME-Tox prediction methodology were used to study the antitumor activity of the most active compounds and to identify the structural features required for antitumor activity.

  8. Design, Synthesis, and Preclinical Evaluations of Novel 4-Substituted 1,5-Diarylanilines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Drug Candidates

    PubMed Central

    Sun, Lian-Qi; Zhu, Lei; Qian, Keduo; Qin, Bingjie; Huang, Li; Chen, Chin Ho; Lee, Kuo-Hsiung; Xie, Lan

    2012-01-01

    Twenty-one new 4-substituted diarylaniline compounds (DAANs) (Scheme 2, series 13, 14, and 15) were designed, synthesized, and evaluated against wild-type and drug resistant HIV-1 viral strains. As a result, approximately a dozen new DAANs showed high potency with low nano- to sub-nanomolar EC50 values ranging from 0.2 to 10 nM. The three most promising compounds 14e, 14h, and 15h exhibited high potency against wild-type and drug-resistant viral strains with EC50 values at the sub-nanomolar level (0.29–0.87 nM), and were comparable to or more potent than the new NNRTI drug riplivirine (2) in the same assays. Drug-like physicochemical property assessments revealed that the most active DAANs (EC50 <10 nM) have better aqueous solubility (>1–90 μg/mL at pH 7.4 and pH 2) and metabolic stability in vitro than 2, as well as desirable log P values (<5) and polar surface area (PSA) (<140 Å2). These promising results warrant further development of this novel compound class as potential potent anti-AIDS clinical trial candidates. PMID:22856541

  9. Study protocol for a scoping review on rehabilitation scoping reviews.

    PubMed

    Colquhoun, Heather L; Jesus, Tiago S; O'Brien, Kelly K; Tricco, Andrea C; Chui, Adora; Zarin, Wasifa; Lillie, Erin; Hitzig, Sander L; Straus, Sharon

    2017-09-01

    Scoping reviews are increasingly popular in rehabilitation. However, significant variability in scoping review conduct and reporting currently exists, limiting potential for the methodology to advance rehabilitation research, practice and policy. Our aim is to conduct a scoping review of rehabilitation scoping reviews in order to examine the current volume, yearly distribution, proportion, scope and methodological practices involved in the conduct of scoping reviews in rehabilitation. Key areas of methodological improvement will be described. Methods and analysis: We will undertake the review using the Arksey and O'Malley scoping review methodology. Our search will involve two phases. The first will combine a previously conducted scoping review of scoping reviews (not distinct to rehabilitation, with data current to July 2014) together with a rehabilitation keyword search in PubMed. Articles found in the first phase search will undergo a full text review. The second phase will include an update of the previously conducted scoping review of scoping reviews (July 2014 to current). This update will include the search of nine electronic databases, followed by title and abstract screening as well as a full text review. All screening and extraction will be performed independently by two authors. Articles will be included if they are scoping reviews within the field of rehabilitation. A consultation exercise with key targets will inform plans to improve rehabilitation scoping reviews. Ethics and dissemination: Ethics will be required for the consultation phase of our scoping review. Dissemination will include peer-reviewed publication and conferences in rehabilitation-specific contexts.

  10. Oxidizer Scoping Studies

    SciTech Connect

    Chancellor, Christopher John

    2016-11-07

    The purpose of this report is to present the results of the acceptable knowledge (AK) review of oxidizers present in active waste streams, provide a technical analysis of the oxidizers, and report the results of the scoping study testing. This report will determine the fastest burning oxidizer to be used in the development of a Test Plan for Preparation and Testing of Sorbents Mixed with Oxidizer found in Transuranic Waste (DWT-TP-001). The companion report, DWT-RPT-002, Sorbent Scoping Studies, contains similar information for sorbents identified during the AK review of TRU waste streams. The results of the oxidizer and sorbent scoping studies will be used to inform the QL1 test plan. The QL1 test results will support the development of a basis of knowledge document that will evaluate oxidizing chemicals and sorbents in TRU waste and provide guidance for treatment.

  11. LogScope

    NASA Technical Reports Server (NTRS)

    Havelund, Klaus; Smith, Margaret H.; Barringer, Howard; Groce, Alex

    2012-01-01

    LogScope is a software package for analyzing log files. The intended use is for offline post-processing of such logs, after the execution of the system under test. LogScope can, however, in principle, also be used to monitor systems online during their execution. Logs are checked against requirements formulated as monitors expressed in a rule-based specification language. This language has similarities to a state machine language, but is more expressive, for example, in its handling of data parameters. The specification language is user friendly, simple, and yet expressive enough for many practical scenarios. The LogScope software was initially developed to specifically assist in testing JPL s Mars Science Laboratory (MSL) flight software, but it is very generic in nature and can be applied to any application that produces some form of logging information (which almost any software does).

  12. Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole-coumarin hybrids.

    PubMed

    Kraljević, Tatjana Gazivoda; Harej, Anja; Sedić, Mirela; Pavelić, Sandra Kraljević; Stepanić, Višnja; Drenjančević, Domagoj; Talapko, Jasminka; Raić-Malić, Silvana

    2016-11-29

    The 4-substituted 1,2,3-triazole core in designed coumarin hybrids (4-35) with diverse physicochemical properties was introduced by eco-friendly copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition under microwave irradiation. Coumarin-1,2,3-triazole-benzofused heterocycle hybrids emerged as the class of compounds exhibiting the highest antiproliferative activity. The strong relationship between lipophilicity and antiproliferative activities was observed indicating that lipophilic 1,2,3-triazole-coumarin hybrids containing phenylethyl (13), 3,5-difluorophenyl (14), 5-iodoindole (30) and benzimidazole (33 and 35) subunits showed the most potent cytostatic effects. The 7-methylcoumarin-1,2,3-triazole-2-methylbenzimidazole hybrid 33 can be highlighted as a lead that exerted the highest cytotoxicity against hepatocellular carcinoma HepG2 cells with IC50 value of 0.9 μM and high selectivity (SI = 50). This compound induced cell death, mainly due to early apoptosis. Strong antiproliferative effect of 33 could be associated with its inhibition of 5-lipoxygenase (5-LO) activity and perturbation of sphingolipid signaling by interfering with intracellular acid ceramidase (ASAH) activity. Outlined considerable effect of lipophilicity on antiproliferative activity was not observed for antibacterial activity. The compounds with p-pentylphenyl (17), 2-chloro-4-fluorobenzenesulfonamide (23) and dithiocarbamate (27) moiety were endowed with high selectivity against Enterococcus species. Moreover, these compounds were found to be superior in inhibiting the growth of clinically isolated vancomycin-resistant Enterococcus faecium, while the reference antibiotics exhibited the lack of activity. Our findings indicate that coumarin-1,2,3-triazole could be used as the scaffold for structural optimization to develop more potent and selective anticancer agents and encourage further development of novel structurally related analogs of 33 as more effective 5-LO inhibitors. Copyright

  13. Quantitative structure-activity relationship for the cleavage of C3/C4-substituted catechols by a prototypal extradiol catechol dioxygenase with broad substrate specificity.

    PubMed

    Ishida, Tetsuo; Tanaka, Hiroyuki; Horiike, Kihachiro

    2004-06-01

    Catechol 2,3-dioxygenase [EC 1.13.11.2] from Pseudomonas putida mt-2 (Mpc) catalyzes the extradiol cleavage of catechol to produce 2-hydroxymuconate semialdehyde. The K(m) values for the catecholic substrate (K(mA)) and O(2) (K(mO2)), and catalytic constants (k(cat)) were kinetically determined for eight C3/C4-substituted catechols at 25 degrees C and pH 6.5 or 7.5. The first pK(a) values (pK(1)) were determined for eleven catechols (pK(1) = 7.26-9.47), correlated with Hammett substituent constants, and electron-withdrawing substituents significantly stabilized the monoanionic species of free catechols. Mpc preferred catechols with non-ionic substituents at the C3 or C4 position. 3-Phenylcatechol, a biphenyl, was cleaved, while 4-tert-butylcatechol was not. The logarithm of k(cat)/K(mA) (substrate specificity constant) exhibited a good linear correlation with pK(1), with the exception of those for 4-halocatechols. The logarithm of k(cat)/K(mO2) showed a good linear correlation with pK(1), with the exception of that of 3-phenylcatechol. These results demonstrate that catechol binding to the Mpc active site, the following O(2) binding, and the activation of the bound O(2) are all sensitive to electronic effects of the substituents. However, k(cat) did not correlate significantly with pK(1). The present study distinguishes clearly between the electronic and the steric effects of catecholic substrates in the reactivity of Mpc, and provides important insight into the mechanistic basis for a vast range of substrate specificities of extradiol dioxygenases.

  14. Structural and theoretical characterization of a new twisted 4'-substituted terpyridine compound: 4'-(isoquinolin-4-yl)-2,2':6',2''-terpyridine.

    PubMed

    Granifo, Juan; Arévalo, Beatriz; Gaviño, Rubén; Suárez, Sebastián; Baggio, Ricardo

    2016-12-01

    4'-Substituted derivatives of 2,2':6',2''-terpyridine with N-containing heteroaromatic substituents, such as pyridyl groups, might be able to coordinate metal centres through the extra N-donor atom, in addition to the chelating terpyridine N atoms. The incorporation of these peripheral N-donor sites would also allow for the diversification of the types of noncovalent interactions present, such as hydrogen bonding and π-π stacking. The title compound, C24H16N4, consists of a 2,2':6',2''-terpyridine nucleus (tpy), with a pendant isoquinoline group (isq) bound at the central pyridine (py) ring. The tpy nucleus deviates slightly from planarity, with interplanar angles between the lateral and central py rings in the range 2.24 (7)-7.90 (7)°, while the isq group is rotated significantly [by 46.57 (6)°] out of this planar scheme, associated with a short Htpy...Hisq contact of 2.32 Å. There are no strong noncovalent interactions in the structure, the main ones being of the π-π and C-H...π types, giving rise to columnar arrays along [001], further linked by C-H...N hydrogen bonds into a three-dimensional supramolecular structure. An Atoms In Molecules (AIM) analysis of the noncovalent interactions provided illuminating results, and while confirming the bonding character for all those interactions unquestionable from a geometrical point of view, it also provided answers for some cases where geometric parameters are not informative, in particular, the short Htpy...Hisq contact of 2.32 Å to which AIM ascribed an attractive character.

  15. Spectrophotometric, voltammetric and cytotoxicity studies of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its N(4)-substituted derivatives: A combined experimental-computational study

    NASA Astrophysics Data System (ADS)

    Akgemci, Emine Guler; Saf, Ahmet Ozgur; Tasdemir, Halil Ugur; Türkkan, Ercan; Bingol, Haluk; Turan, Suna Ozbas; Akkiprik, Mustafa

    2015-02-01

    In this study, 2-hydroxy-5-methoxyacetophenone thiosemicarbazone (HMAT) and its novel N(4) substituted derivatives were synthesized and characterized by different techniques. The optical band gap of the compounds and the energy of HOMO were experimentally examined by UV-vis spectra and cyclic voltammetry measurements, respectively. Furthermore, the conformational spaces of the compounds were scanned with molecular mechanics method. The geometry optimization, HOMO and LUMO energies, the energy gap of the HOMO-LUMO, dipole moment of the compounds were theoretically calculated by the density functional theory B3LYP/6-311++G(d,p) level. The minimal electronic excitation energy and maximum wavelength calculations of the compounds were also performed by TD-DFT//B3LYP/6-311++G(d,p) level of theory. Theoretically calculated values were compared with the related experimental values. The combined results exhibit that all compounds have good electron-donor properties which affect anti-proliferative activity. The cytotoxic effects of the compounds were also evaluated against HeLa (cervical carcinoma), MCF-7 (breast carcinoma) and PC-3 (prostatic carcinoma) cell lines using the standard MTT assay. All tested compounds showed antiproliferative effect having IC50 values in different range. In comparison with that of HMAT, it was obtained that while ethyl group on 4(N)-substituted position decreased in potent anti-proliferative effect, the phenyl group on the position increased in anti-proliferative effect for the tested cancer cell line. Considering the molecular energy parameters, the cytotoxicity activities of the compounds were discussed.

  16. Crystal and molecular structure studies of (Z)-N-methyl-C-4-substituted phenyl nitrones by XRD, DFT, FTIR and NMR methods

    NASA Astrophysics Data System (ADS)

    Lasri, Jamal; Eltayeb, Naser Eltaher; Haukka, Matti; Alghamdi, Yousef

    2017-01-01

    (Z)-N-methyl-C-4-substituted phenyl nitrones -O+N(Me)=C(H)R (Z-2a R = 4-ClC6H4, Z-2b R = 4-NO2C6H4, Z-2c R = 4-CH3OC6H4) were synthesized and characterized by elemental analyses, FTIR, 1H, 13C and DEPT-135 NMR spectroscopy and also by single crystal X-ray diffraction (in the case of Z-2a and Z-2b). The geometries of the nitrone molecules Z-2a, Z-2b and Z-2c and their E-isomers; (E)-N-methyl-C-4-chlorophenyl nitrone E-2a, (E)-N-methyl-C-4-nitrophenyl nitrone E-2b and (E)-N-methyl-C-4-methoxyphenyl nitrone E-2c were optimized using density functional theory (DFT) at the B3LYP/6-311++G(d,p) level of theory. The theoretical vibrational frequencies obtained by DFT calculations are in good agreement with the experimental values. The electronics structures were described in terms of the distribution of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO). Gauge independent atomic orbital (GIAO) method was used to calculate the NMR spectra, the correlation between the calculated and experimental chemical shifts is mostly in the range of 0.94-0.97 for 1H, whereas, the correlation for 13C is 0.99. Thermodynamics study showed that the Z-isomer is favoured than E-isomer with energy barrier of 7.1, 7.2 and 7.1 kcal/mol for Z-2a, Z-2b and Z-2c, respectively. The abundance of the most stable species Z-isomers is equal to 99.99% for all three compounds at 298 K in gas phase.

  17. Cosmetology: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for a cosmetology vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and the…

  18. Welding: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    Intended for use by all welding instructors in the Metropolitan Nashville Public Schools, this guide provides a sequential listing of course content and scope. A course description provides a brief overview of the content of the courses offered in the welding program. General course objectives are then listed. Outlines of the course content are…

  19. Agriculture: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This guide, which was written as an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System, outlines the suggested scope and sequence of a 3-year program in agriculture. The guide consists of a course description; general course objectives;…

  20. SCOPE in Cataloguing.

    ERIC Educational Resources Information Center

    Tom, Ellen; Reed, Sue

    This report describes the Systematic Computerized Processing in Cataloguing system (SCOPE), an automated system for the catalog department of a university library. The system produces spine labels, pocket labels, book cards for the circulation system, catalog cards including shelf list, main entry, subject and added entry cards, statistics, an…

  1. Welding: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    Intended for use by all welding instructors in the Metropolitan Nashville Public Schools, this guide provides a sequential listing of course content and scope. A course description provides a brief overview of the content of the courses offered in the welding program. General course objectives are then listed. Outlines of the course content are…

  2. Cosmetology: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for a cosmetology vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and the…

  3. Agriculture: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This guide, which was written as an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System, outlines the suggested scope and sequence of a 3-year program in agriculture. The guide consists of a course description; general course objectives;…

  4. Frozen Scope and Grammatical Optimization

    ERIC Educational Resources Information Center

    Freedman, Michael

    2014-01-01

    The literature on quantifier scope has repeatedly observed that some otherwise expected permutations of scope taking elements are unavailable. Various methods have been proffered explaining these facts. This thesis aims to unify three disparate areas where the scope of operators seems to be frozen: the interaction of universal quantifiers with…

  5. Frozen Scope and Grammatical Optimization

    ERIC Educational Resources Information Center

    Freedman, Michael

    2014-01-01

    The literature on quantifier scope has repeatedly observed that some otherwise expected permutations of scope taking elements are unavailable. Various methods have been proffered explaining these facts. This thesis aims to unify three disparate areas where the scope of operators seems to be frozen: the interaction of universal quantifiers with…

  6. Crystal structures of three 4-substituted-2,2′-bipyridines synthesized by Sonogashira and Suzuki–Miyaura cross-coupling reactions

    PubMed Central

    Luong Thi Thu, Thuy; Nguyen Bich, Ngan; Nguyen, Hien

    2017-01-01

    Facile synthetic routes for three 4-substituted 2,2′-bi­pyridine derivatives, 4-[2-(4-methyl­phenyl)­ethyn­yl]-2,2′-bi­pyridine, C19H14N2, (I), 4-[2-(pyridin-3-yl)ethyn­yl]-2,2′-bi­pyridine, C17H11N3, (II), and 4-(indol-4-yl)-2,2′-bi­pyridine, C18H13N3, (III), via Sonogashira and Suzuki–Miyaura cross-coupling reactions, respect­ively, are described. As indicated by X-ray analysis, the 2,2′-bi­pyridine core, the ethyl­ene linkage and the substituents of (I) and (II) are almost planar [dihedral angles between the two ring systems: 8.98 (5) and 9.90 (6)° for the two mol­ecules of (I) in the asymmetric unit and 2.66 (14)° for (II)], allowing π-conjugation. On the contrary, in (III), the indole substituent ring is rotated significantly out of the bi­pyridine plane [dihedral angle = 55.82 (3)°], due to steric hindrance. The crystal packings of (I) and (II) are dominated by π–π inter­actions, resulting in layers of mol­ecules parallel to (30-2) in (I) and columns of mol­ecules along the a axis in (II). The packing of (III) exhibits zigzag chains of mol­ecules along the c axis inter­acting through N—H⋯N hydrogen bonds and π–π inter­actions. The contributions of unknown disordered solvent mol­ecules to the diffraction intensities in (II) were removed with the SQUEEZE [Spek (2015 ▸). Acta Cryst. C71, 9–18] algorithm of PLATON. The given chemical formula and other crystal data do not take into account these solvent mol­ecules. PMID:28435732

  7. Ventilation technologies scoping study

    SciTech Connect

    Walker, Iain S.; Sherman, Max H.

    2003-09-30

    This document presents the findings of a scoping study commissioned by the Public Interest Energy Research (PIER) program of the California Energy Commission to determine what research is necessary to develop new residential ventilation requirements for California. This study is one of three companion efforts needed to complete the job of determining the needs of California, determining residential ventilation requirements, and determining appropriate ventilation technologies to meet these needs and requirements in an energy efficient manner. Rather than providing research results, this scoping study identifies important research questions along with the level of effort necessary to address these questions and the costs, risks, and benefits of pursuing alternative research questions. In approaching these questions and level of effort, feasibility and timing were important considerations. The Commission has specified Summer 2005 as the latest date for completing this research in time to update the 2008 version of California's Energy Code (Title 24).

  8. Sorbent Scoping Studies

    SciTech Connect

    Chancellor, Christopher John

    2016-11-14

    The Los Alamos National Laboratory – Carlsbad Operations (LANL-CO) office was tasked by the DOE CBFO, Office of the Manager to: • Perform a review of the acceptable knowledge (AK) to identify the oxidizers and sorbents in transuranic (TRU) waste streams. • Conduct scoping studies on the oxidizers and sorbents identified in AK review to inform the Quality Level 1 (QL1) testing. • Conduct a series of QL1 tests to provide the scientific data to support a basis of knowledge document for determining the criteria for: 1) accepting waste at the Waste Isolation Pilot Plant (WIPP) without treatment, 2) determining waste that will require treatment, and 3) if treatment is required, how the treatment must be performed. The purpose of this report is to present the results of the AK review of sorbents present in active waste streams, provide a technical analysis of the sorbent list, report the results of the scoping studies for the fastest burning organic sorbent, and provide the list of organic and inorganic sorbents to be used in the development of a Test Plan for Preparation and Testing of Sorbents Mixed with Oxidizer found in Transuranic Waste (DWT-TP-001). The companion report, DWT-RPT-001, Oxidizer Scoping Studies, has similar information for oxidizers identified during the AK review of TRU waste streams. The results of the oxidizer and sorbent scoping studies will be used to inform the QL1 test plan. The QL1 test results will support the development of a basis of knowledge document that will evaluate oxidizing chemicals and sorbents in TRU waste and provide guidance for treatment.

  9. Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes.

    PubMed

    Finke, P E; Meurer, L C; Oates, B; Shah, S K; Loebach, J L; Mills, S G; MacCoss, M; Castonguay, L; Malkowitz, L; Springer, M S; Gould, S L; DeMartino, J A

    2001-09-17

    Structure-activity relationship studies directed toward the optimization of (2S)-2-(3-chlorophenyl)-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-[4-(substituted)piperidin-1-yl]butanes as CCR5 antagonists resulted in the synthesis of the spiro-indanone derivative 8c (IC50=5 nM). These and previous results are summarized in a proposed pharmacophore model for this class of CCR5 antagonist.

  10. Synthesis, characterization and anticonvulsant activity evaluation of some 1,4-dihydropyridines and 3,5-(substituted)oxycarbonyl-1,4-dihydro-2,6-dimethyl-N-[2-(4-sulfamoylphenylamino)-acetyl]-4-(substituted)pyridines.

    PubMed

    Subudhi, Bharat Bhusan; Panda, Prasanna K; Swain, Sarada P; Sarangi, Priyambada

    2009-01-01

    A series of 3,5-(substituted)oxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(substituted)pyridines (1a-j) were synthesized by Hantzsch method for pyridine synthesis. Treatment with chloroacetyl chloride produced N-(2-chloroacetyl)-3,5-(substituted)oxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(substituted)pyridines (2a-e), which on further treatment with sulfanilamide resulted in 3,5-(substituted)oxycarbonyl-1,4-dihydro-2,6-dimethyl-N-[2-(4-sulfamoylphenylamino)-acetyl]-4-(substituted)pyridines (3a-e). The structures has been established on the basis of spectral (IR, 1H-NMR, mass) and elemental analysis. Compounds 1a-j and 3a-e (5 mg/kg and 10 mg/kg) were evaluated for their anticonvulsant effect against pentylenetetrazole-induced convulsions with diazepam (4 mg/kg) as the reference. Compounds 3a-e exhibited significant (p<0.01) anticonvulsant activity compared to the control.

  11. The SCOPE Mission

    SciTech Connect

    Fujimoto, M.; Tsuda, Y.; Saito, Y.; Shinohara, I.; Takashima, T.; Matsuoka, A.; Kojima, H.; Kasaba, Y.

    2009-06-16

    In order to reach the new horizon of the space physics research, the Plasma Universe, via in-situ measurements in the Earth's magnetosphere, SCOPE will perform formation flying observations combined with high-time resolution electron measurements. The simultaneous multi-scale observations by SCOPE of various plasma dynamical phenomena will enable data-based study of the key space plasma processes from the cross-scale coupling point of view. Key physical processes to be studied are magnetic reconnection under various boundary conditions, shocks in space plasma, collisionless plasma mixing at the boundaries, and physics of current sheets embedded in complex magnetic geometries. The SCOPE formation is made up of 5 spacecraft and is put into the equatorial orbit with the apogee at 30 Re (Re: earth radius). One of the spacecraft is a large mother ship which is equipped with a full suite of particle detectors including ultra-high time resolution electron detector. Among other 4 small spacecraft, one remains near ({approx}10 km) the mother ship and the spacecraft-pair will focus on the electron-scale physics. Others at the distance of 100{approx}3000 km(electron{approx}ion spatial scales) from the mother ship will monitor plasma dynamics surrounding the mother-daughter pair. There is lively on-going discussion on Japan-Europe international collaboration (ESA's Cross-Scale), which would certainly make better the coverage over the scales of interest and thus make the success of the mission, i.e., clarifying the multi-scale nature of the Plasma Universe, to be attained at an even higher level.

  12. Scope of practice.

    PubMed

    Fish, M S

    1982-01-01

    Physicians, paramedical personnel, registered nurses, licensed practical nurses, aides, technicians, therapists, and many other specialists deliver health care in the current system. The uncertainty is the division of authority and responsibility, the right of dominion and control, and the appropriate legal manner in which quality assurance can be achieved. The public needs to know to whom they may look for the purpose of response to needs, and responsibility for actions outside the scope of licensed and permitted activities. Practitioners also need to know--in order to avoid prosecution, conviction, fine, imprisonment, and loss of livelihood through loss of license.

  13. EarthScope Website Revised

    NASA Astrophysics Data System (ADS)

    Blackman, B.; Lee, E.; Jackson, M.

    2007-12-01

    EarthScope is an ambitious, multidisciplinary program funded by the National Science Foundation to explore the structure and evolution of the North American continent and understand processes controlling earthquakes and volcanoes. The EarthScope program web site (http://www.earthscope.org) gives an initial introduction to the purpose, scope, and benefits of one of the largest NSF-funded programs ever undertaken. It also acts as the central point of information dissemination for the scientific community and a resource repository for education and outreach purposes. Over the past year, the EarthScope program Web site has been redesigned to simplify access to information while developing a larger focus on the scientific perspective derived from this uniquely inter-disciplinary program. A new categorical orientation of the EarthScope program observatories, instruments, and data availability provides new visitors a more cohesive understanding of the component facility role and a clear introduction to the organizations responsible for each facility. Though the EarthScope program web site primarily provides introductory level information and announcements, new and intuitive features are being implemented routinely. A Beta release of the new EarthScope Google Map allows a broader audience to view and access instrument station information in a way that is familiar and informative. Centralized links to visualizations and other multi-media products that showcase scientific interpretations derived from EarthScope instrument data provides a greater comprehension of the scope and benefits of this program.

  14. Networked Microgrids Scoping Study

    SciTech Connect

    Backhaus, Scott N.; Dobriansky, Larisa; Glover, Steve; Liu, Chen-Ching; Looney, Patrick; Mashayekh, Salman; Pratt, Annabelle; Schneider, Kevin; Stadler, Michael; Starke, Michael; Wang, Jianhui; Yue, Meng

    2016-12-05

    Much like individual microgrids, the range of opportunities and potential architectures of networked microgrids is very diverse. The goals of this scoping study are to provide an early assessment of research and development needs by examining the benefits of, risks created by, and risks to networked microgrids. At this time there are very few, if any, examples of deployed microgrid networks. In addition, there are very few tools to simulate or otherwise analyze the behavior of networked microgrids. In this setting, it is very difficult to evaluate networked microgrids systematically or quantitatively. At this early stage, this study is relying on inputs, estimations, and literature reviews by subject matter experts who are engaged in individual microgrid research and development projects, i.e., the authors of this study The initial step of the study gathered input about the potential opportunities provided by networked microgrids from these subject matter experts. These opportunities were divided between the subject matter experts for further review. Part 2 of this study is comprised of these reviews. Part 1 of this study is a summary of the benefits and risks identified in the reviews in Part 2 and synthesis of the research needs required to enable networked microgrids.

  15. Sustained metabolic scope.

    PubMed

    Peterson, C C; Nagy, K A; Diamond, J

    1990-03-01

    Sustained metabolic rates (SusMR) are time-averaged metabolic rates that are measured in free-ranging animals maintaining constant body mass over periods long enough that metabolism is fueled by food intake rather than by transient depletion of energy reserves. Many authors have suggested that SusMR of various wild animal species are only a few times resting (basal or standard) metabolic rates (RMR). We test this conclusion by analyzing all 37 species (humans, 31 other endothermic vertebrates, and 5 ectothermic vertebrates) for which SusMR and RMR had both been measured. For all species, the ratio of SusMR to RMR, which we term sustained metabolic scope, is less than 7; most values fall between 1.5 and 5. Some of these values, such as those for Tour de France cyclists and breeding birds, are surely close to sustainable metabolic ceilings for the species studied. That is, metabolic rates higher than 7 times RMR apparently cannot be sustained indefinitely. These observations pose several questions: whether the proximate physiological causes of metabolic ceilings reside in the digestive tract's ability to process food or in each tissue's metabolic capacity; whether ceiling values are independent of the mode of energy expenditure; whether ceilings are set by single limiting physiological capacities or by coadjusted clusters of capacities (symmorphosis); what the ultimate evolutionary causes of metabolic ceilings are; and how metabolic ceilings may limit animals' reproductive effort, foraging behavior, and geographic distribution.

  16. Effects of the Scopes Trial

    ERIC Educational Resources Information Center

    Grabiner, Judith V.; Miller, Peter D.

    1974-01-01

    Considered are the effects of the Scopes trial on textbook publishers, textbook writers, and textbooks used in schools. The authors question whether it was a victory for evolutionists or for other groups. (RH)

  17. Residential ventilation standards scoping study

    SciTech Connect

    McKone, Thomas E.; Sherman, Max H.

    2003-10-01

    The goals of this scoping study are to identify research needed to develop improved ventilation standards for California's Title 24 Building Energy Efficiency Standards. The 2008 Title 24 Standards are the primary target for the outcome of this research, but this scoping study is not limited to that timeframe. We prepared this scoping study to provide the California Energy Commission with broad and flexible options for developing a research plan to advance the standards. This document presents the findings of a scoping study commissioned by the Public Interest Energy Research (PIER) program of the California Energy Commission to determine what research is necessary to develop new residential ventilation requirements for California. This study is one of three companion efforts needed to complete the job of determining the ventilation needs of California residences, determining the bases for setting residential ventilation requirements, and determining appropriate ventilation technologies to meet these needs and requirements in an energy efficient manner. Rather than providing research results, this scoping study identifies important research questions along with the level of effort necessary to address these questions and the costs, risks, and benefits of pursuing alternative research questions. In approaching these questions and corresponding levels of effort, feasibility and timing were important considerations. The Commission has specified Summer 2005 as the latest date for completing this research in time to update the 2008 version of California's Energy Code (Title 24).

  18. Scoping for Social Impact Assessment

    SciTech Connect

    Branch, Kristi M.; Ross, Helen

    2000-12-01

    Social assessment combines research, analytic, and participatory processes to identify, describe, and interpret changes in the ?human environment? that result from any of a wide variety of change agents -- projects, policies, or planning activities. Scoping for social impact assessment draws upon these same three processes - research, analysis, and participation - to: - Disclose information about the proposed action, preliminary estimates of impacts, and plans for the decision making and assessment effort - Initiate dialogue with the interested and potentially affected publics and decision makers - Establish the focus and level of detail of the assessment, identify particular issues that need to be addressed, and clarify how potentially affected publics will be consulted and involved. This chapter describes the function and key objectives of the scoping process, explains the assessment framework and the conventions and issues that set the context for the scoping process, provides some suggestions about how to plan and conduct scoping for a social assessment, and discusses some of the key issues that must be addressed in designing an effective scoping process for social impact assessment. Our approach recognises that social scientists may be involved in assessment tasks that involve other disciplinary areas. This may be an Environmental Impact Assessment (EIA), Strategic Environmental Assessment (SEA, the analysis of the impacts of policies or plans, or the combination of impact assessment with planning), or a planning process.

  19. 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies.

    PubMed

    Yan, Gang; Hao, Lina; Niu, Yan; Huang, Wenjie; Wang, Wei; Xu, Fengrong; Liang, Lei; Wang, Chao; Jin, Hongwei; Xu, Ping

    2017-09-08

    In this work, a series of 2-substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamide derivatives were developed as β-secretase (BACE-1) inhibitors. Supported by docking study, a small library of derivatives were designed, synthesized and biologically evaluated in vitro. In addition, the selected compounds were tested with affinity (KD) towards BACE-1, blood brain barrier (BBB) permeability and cytotoxicity. The studies revealed that the most potent analog 41 (IC50 = 4.6 μM) with high predicted BBB permeability and low cellular cytotoxicity, could serve as a good lead structure for further optimization. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  20. The Design and Discovery of Water Soluble 4-Substituted-2,6-dimethylfuro[2,3-d]pyrimidines as Multitargeted Receptor Tyrosine Kinase Inhibitors and Microtubule Targeting Antitumor Agents

    PubMed Central

    Zhang, Xin; Raghavan, Sudhir; Ihnat, Michael; Thorpe, Jessica E.; Disch, Bryan C.; Bastian, Anja; Bailey-Downs, Lora C.; Dybdal-Hargreaves, Nicholas F.; Rohena, Cristina C.; Hamel, Ernest; Mooberry, Susan L.; Gangjee, Aleem

    2014-01-01

    The design, synthesis and biological evaluations of fourteen 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidines are reported. Four compounds (11–13, 15) inhibit vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor β (PDGFR-β), and target tubulin leading to cytotoxicity. Compound 11 has nanomolar potency, comparable to sunitinib and semaxinib, against tumor cell lines overexpressing VEGFR-2 and PDGFR-β. Further, 11 binds at the colchicine site on tubulin, depolymerizes cellular microtubules and inhibits purified tubulin assembly and overcomes both βIII-tubulin and P-glycoprotein-mediated drug resistance, and initiates mitotic arrest leading to apoptosis. In vivo, its HCl salt, 21, reduced tumor size and vascularity in xenograft and allograft murine models and was superior to docetaxel and sunitinib, without overt toxicity. Thus 21 affords potential combination chemotherapy in a single agent. PMID:24890652

  1. Proline Editing: A General and Practical Approach to the Synthesis of Functionally and Structurally Diverse Peptides. Analysis of Steric versus Stereoelectronic Effects of 4-Substituted Prolines on Conformation within Peptides

    PubMed Central

    Pandey, Anil K.; Naduthambi, Devan; Thomas, Krista M.; Zondlo, Neal J.

    2013-01-01

    Functionalized proline residues have diverse applications. Herein we describe a practical approach, proline editing, for the synthesis of peptides with stereospecifically modified proline residues. Peptides are synthesized by standard solid-phase-peptide-synthesis to incorporate Fmoc-Hydroxyproline (4R-Hyp). In an automated manner, the Hyp hydroxyl is protected and the remainder of the peptide synthesized. After peptide synthesis, the Hyp protecting group is orthogonally removed and Hyp selectively modified to generate substituted proline amino acids, with the peptide main chain functioning to “protect” the proline amino and carboxyl groups. In a model tetrapeptide (Ac-TYPN-NH2), 4R-Hyp was stereospecifically converted to 122 different 4-substituted prolyl amino acids, with 4R or 4S stereochemistry, via Mitsunobu, oxidation, reduction, acylation, and substitution reactions. 4-Substituted prolines synthesized via proline editing include incorporated structured amino acid mimetics (Cys, Asp/Glu, Phe, Lys, Arg, pSer/pThr), recognition motifs (biotin, RGD), electron-withdrawing groups to induce stereoelectronic effects (fluoro, nitrobenzoate), handles for heteronuclear NMR (19F:fluoro; pentafluorophenyl or perfluoro-tert-butyl ether; 4,4-difluoro; 77SePh) and other spectroscopies (fluorescence, IR: cyanophenyl ether), leaving groups (sulfonate, halide, NHS, bromoacetate), and other reactive handles (amine, thiol, thioester, ketone, hydroxylamine, maleimide, acrylate, azide, alkene, alkyne, aryl halide, tetrazine, 1,2-aminothiol). Proline editing provides access to these proline derivatives with no solution phase synthesis. All peptides were analyzed by NMR to identify stereoelectronic and steric effects on conformation. Proline derivatives were synthesized to permit bioorthogonal conjugation reactions, including azide-alkyne, tetrazinetrans-cyclooctene, oxime, reductive amination, native chemical ligation, Suzuki, Sonogashira, cross-metathesis, and Diels

  2. Switch on Micro*scope!

    ERIC Educational Resources Information Center

    Roland, Sarah; Bahr, Michele; Olendzenski, Lorraine; Patterson, David J.

    2005-01-01

    Scientists at the Marine Biological Laboratory in Woods Hole, Massachusetts, have created micro*scope, a free, searchable knowledge environment for exploring the microbial world. Microbiology can easily be incorporated into the curriculum, because microbial communities are easy to access. Organisms grow quickly, making certain arrays of…

  3. VOE Accounting: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This guide, which was written as an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System, outlines the suggested scope and sequence of a 2-year program in accounting. The guide consists of a course description; general course objectives;…

  4. Diesel Mechanics: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for a diesel mechanics vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and the…

  5. Auto Mechanics: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for an auto mechanics vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and the…

  6. Urban Horticulture: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This guide, which was written as an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System, outlines the suggested scope and sequence of a 4-year program in urban horticulture. The guide consists of a course description; general course…

  7. Machine Shop: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    Intended for use by all machine shop instructors in the Metropolitan Nashville Public Schools, this guide provides a sequential listing of course content and scope. A course description provides a brief overview of the content of the courses offered in the machine shop program. General course objectives are then listed. Outlines of the course…

  8. Urban Horticulture: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This guide, which was written as an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System, outlines the suggested scope and sequence of a 4-year program in urban horticulture. The guide consists of a course description; general course…

  9. Health Occupations: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This guide, which was written as an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System, outlines the suggested scope and sequence of a 3-year program in health occupations. The guide consists of a course description; general course…

  10. ZooScope. Teacher's Packet.

    ERIC Educational Resources Information Center

    Henrie, Charis

    This curriculum provides background information and activities for teaching inquiry-based science in the classroom and at the Oregon Zoo. The ZooScope program was created to provide students with hands-on and minds-on activities that are crucial to taking theoretical learning into the real world. The hope is that as students begin asking about the…

  11. Switch on Micro*scope!

    ERIC Educational Resources Information Center

    Roland, Sarah; Bahr, Michele; Olendzenski, Lorraine; Patterson, David J.

    2005-01-01

    Scientists at the Marine Biological Laboratory in Woods Hole, Massachusetts, have created micro*scope, a free, searchable knowledge environment for exploring the microbial world. Microbiology can easily be incorporated into the curriculum, because microbial communities are easy to access. Organisms grow quickly, making certain arrays of…

  12. Commercial Art: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for a commercial art vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and the…

  13. VOE Accounting: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This guide, which was written as an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System, outlines the suggested scope and sequence of a 2-year program in accounting. The guide consists of a course description; general course objectives;…

  14. VOE Clerical: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This guide, which was written as an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System, outlines the suggested scope and sequence of a 2-year program in clerical skills. The guide consists of a course description; general course…

  15. Aircraft Mechanics: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for an aircraft mechanics vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and…

  16. Aircraft Mechanics: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for an aircraft mechanics vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and…

  17. Auto Mechanics: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for an auto mechanics vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and the…

  18. Diesel Mechanics: Scope and Sequence.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for a diesel mechanics vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and the…

  19. 78 FR 32372 - Notice of Scope Rulings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... within the scope of the antidumping duty order; December 17, 2012. A-570-937/C-570-938: Citric Acid and... Corporation; aluminum anodes for water heaters are not within the scope of the antidumping duty and...

  20. 27 CFR 18.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Scope § 18.1 Scope. The regulations in... for the manufacture of volatile fruit-flavor concentrate (essence). The regulations in this part...

  1. 27 CFR 18.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Scope § 18.1 Scope. The regulations in... for the manufacture of volatile fruit-flavor concentrate (essence). The regulations in this part...

  2. 18 CFR 707.10 - Scoping.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Scoping. 707.10 Section 707.10 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water Resources Council Implementing Procedures § 707.10 Scoping. Scoping...

  3. 18 CFR 707.10 - Scoping.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Scoping. 707.10 Section 707.10 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water Resources Council Implementing Procedures § 707.10 Scoping. Scoping...

  4. 18 CFR 707.10 - Scoping.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Scoping. 707.10 Section 707.10 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water Resources Council Implementing Procedures § 707.10 Scoping. Scoping...

  5. 18 CFR 707.10 - Scoping.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Scoping. 707.10 Section 707.10 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water Resources Council Implementing Procedures § 707.10 Scoping. Scoping...

  6. 25 CFR 38.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., DEPARTMENT OF THE INTERIOR EDUCATION EDUCATION PERSONNEL § 38.1 Scope. (a) Primary scope. This part applies to all individuals appointed or converted to contract education positions as defined in § 38.3 in the... positions and agency education positions. (b) Secondary scope. Section 38.13 applies to employees...

  7. 40 CFR 1508.25 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Scope. 1508.25 Section 1508.25 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.25 Scope. Scope consists of the range of actions, alternatives, and impacts to be considered in an environmental impact...

  8. 40 CFR 1508.25 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Scope. 1508.25 Section 1508.25 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.25 Scope. Scope consists of the range of actions, alternatives, and impacts to be considered in an environmental impact...

  9. 40 CFR 1501.7 - Scoping.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Scoping. 1501.7 Section 1501.7 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY NEPA AND AGENCY PLANNING § 1501.7 Scoping. There... as practicable after its decision to prepare an environmental impact statement and before the scoping...

  10. 13 CFR 106.100 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Scope. 106.100 Section 106.100 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION COSPONSORSHIPS, FEE AND NON-FEE BASED SBA-SPONSORED ACTIVITIES AND GIFTS Scope and Definitions § 106.100 Scope. The regulations in this part apply to...

  11. 18 CFR 707.10 - Scoping.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Scoping. 707.10 Section 707.10 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water Resources Council Implementing Procedures § 707.10 Scoping. Scoping...

  12. Rural Idaho Family Physicians' Scope of Practice

    ERIC Educational Resources Information Center

    Baker, Ed; Schmitz, David; Epperly, Ted; Nukui, Ayaka; Miller, Carissa Moffat

    2010-01-01

    Context: Scope of practice is an important factor in both training and recruiting rural family physicians. Purpose: To assess rural Idaho family physicians' scope of practice and to examine variations in scope of practice across variables such as gender, age and employment status. Methods: A survey instrument was developed based on a literature…

  13. 11 CFR 9031.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Scope. 9031.1 Section 9031.1 Federal Elections FEDERAL ELECTION COMMISSION PRESIDENTIAL ELECTION CAMPAIGN FUND: PRESIDENTIAL PRIMARY MATCHING FUND SCOPE § 9031.1 Scope. This subchapter governs entitlement to and use of funds certified from the...

  14. Rural Idaho Family Physicians' Scope of Practice

    ERIC Educational Resources Information Center

    Baker, Ed; Schmitz, David; Epperly, Ted; Nukui, Ayaka; Miller, Carissa Moffat

    2010-01-01

    Context: Scope of practice is an important factor in both training and recruiting rural family physicians. Purpose: To assess rural Idaho family physicians' scope of practice and to examine variations in scope of practice across variables such as gender, age and employment status. Methods: A survey instrument was developed based on a literature…

  15. 32 CFR 651.48 - Scoping process.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Scoping process. 651.48 Section 651.48 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Public Involvement and the Scoping Process § 651.48 Scoping...

  16. 32 CFR 651.48 - Scoping process.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Scoping process. 651.48 Section 651.48 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Public Involvement and the Scoping Process § 651.48 Scoping...

  17. 32 CFR 651.48 - Scoping process.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Scoping process. 651.48 Section 651.48 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Public Involvement and the Scoping Process § 651.48 Scoping...

  18. Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea.

    PubMed

    Kashaw, Sushil K; Kashaw, Varsha; Mishra, Pradeep; Jain, N K; Stables, J P

    2009-11-01

    Several new 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea were synthesized and screened for anticonvulsant, CNS depressant and sedative-hypnotic activity in the mice. After i.p. injection to mice at doses of 30, 100, and 300 mg/kg body weight synthesized compounds were examined in the maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in mice. Spectroscopic data and elemental analysis were consistent with the newly synthesized compounds. The neurotoxicity was assessed using the rotorod method. Compounds E1, E6, E9, E12, P3, P4 and P6 were found to be active in the MES screen whereas E1, P4, P6 and P11 were found to be active in the scPTZ screen. All except E6, E11 and P6 showed more than 50% decrease in locomotor activity at 1h of compound administration via actophotometer screen. CNS depressant activity screened with the help of the forced swim method resulted into some potent compounds. All the compounds were found to exhibit potent CNS depressants activity as indicated by increased immobility time. It can be concluded that newly synthesized compounds possessed promising CNS activities.

  19. The antinociceptive effect of 4-substituted derivatives of 5-(4-chlorophenyl)-2-(morpholin-4-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in mice.

    PubMed

    Joanna, Listos; Talarek, Sylwia; Orzelska, Jolanta; Fidecka, Sylwia; Wujec, Monika; Plech, Tomasz

    2014-04-01

    The aim of the present experiments was to examine the antinociceptive activity of 4-substituted derivatives of 5-(4-chlorophenyl)-2-(morpholin-4-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in mice. The compounds were synthesized using the so-called Mannich reaction and their structures were confirmed using IR and 1H-NMR spectra. The antinociceptive activity was investigated in two behavioral tests: the hot plate test and the writhing test. For preliminary estimation of other behavioral effects, the locomotor activity of mice, the motor coordination in the rota-rod test, and the myorelaxation in the chimney test were also studied. The changes in body temperature of animals were also recorded. We demonstrated that all examined compounds produced antinociceptive effect, both in the hot plate test and in the writhing test, without impact on the motor coordination and myorelaxation of animals. The pharmacological effect of all drugs has been developed within 60 min after administration of drugs; and in two cases (T-103 and T-104), it has been a short-lasting effect (up to 90 min). Two compounds (T-100 and T-102) also inhibited the locomotor activity of animals. T-104 induced the changes in body temperature of mice. Generally, we demonstrated that combination of two different heterocyclic systems (morpholine and 1,2,4-triazole) might be beneficial for reduction of nociception.

  20. Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: lead identification and SAR of 3- and 4-substituted derivatives.

    PubMed

    Genin, M J; Biles, C; Keiser, B J; Poppe, S M; Swaney, S M; Tarpley, W G; Yagi, Y; Romero, D L

    2000-03-09

    Through computationally directed broad screening, a novel 1, 5-diphenylpyrazole (DPP) class of HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) has been discovered. Compound 2 (PNU-32945) was found to have good activity versus wild-type (IC(50) = 2.3 microM) and delavirdine-resistant P236L (IC(50) = 1.1 microM) reverse transcriptase (RT). Also, PNU-32945 has an ED(50) for inhibition of viral replication in cell cultures of 0.1 microM and was shown to be noncytotoxic with a CC(50) > 10 microM. Structure-activity relationship studies on the 3- and 4-positions of PNU-32945 led to interesting selectivity and activity within the class. In particular, the 3-hydroxyethyl-4-ethyl congener 29 is a potent inhibitor of the P236L mutant (IC(50) = 0.65 microM), whereas it is essentially inactive versus the wild-type enzyme (IC(50) > 50 microM). Furthermore, this compound was significantly more active versus the P236L mutant than delavirdine. The synthesis and RT inhibitory activity of various 3- and 4-substituted analogues are discussed.

  1. The Design, Synthesis and Biological Evaluation of Conformationally Restricted 4-Substituted-2,6-dimethylfuro[2,3-d]pyrimidines as Multi-targeted Receptor Tyrosine Kinase and Microtubule Inhibitors as Potential Antitumor Agents

    PubMed Central

    Zhang, Xin; Raghavan, Sudhir; Ihnat, Michael; Hamel, Ernest; Zammiello, Cynthia; Bastian, Anja; Mooberry, Susan L.; Gangjee, Aleem

    2015-01-01

    A series of eleven conformationally restricted, 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidines was designed to explore the bioactive conformation required for dual inhibition of microtubule assembly and receptor tyrosine kinases (RTKs), and their biological activities are reported. All three rotatable single bonds in the lead compound 1 were sequentially restricted to address the role of each in SAR for microtubule and RTK inhibitory effects. Compounds 2, 3, 7 and 10 showed microtubule depolymerizing activity comparable to or better than the lead 1, some with nanomolar EC50 values. While compound 8 had no effect on microtubules, 8 and 10 both showed potent RTK inhibition with nanomolar IC50s. These compounds confirm that the bioactive conformation for RTK inhibition is different from that for tubulin inhibition. The tetrahydroquinoline analog 10 showed the most potent dual tubulin and RTK inhibitory activities (low nanomolar inhibition of EGFR, VEGFR2 and PDGFR-β). Compound 10 is highly potent activity against many NCI cancer cell lines, including several chemo-resistant cell lines, and could serve as a lead for further preclinical studies. PMID:25882519

  2. Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase.

    PubMed

    Chen, Yi-Fong; Lin, Yi-Chien; Huang, Po-Kai; Chan, Hsu-Chin; Kuo, Sheng-Chu; Lee, Kuo-Hsiung; Huang, Li-Jiau

    2013-09-01

    Novel 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives 12a-n were designed and prepared through an intramolecular cyclization reaction and evaluated for in vitro anticancer activity. Among the synthesized compounds, 6,7-methylenedioxy-4-(2,4-dimethoxyphenyl)quinolin-2(1H)-one (12e) displayed potent cytotoxicity against several different tumor cell lines at a sub-micromolar level. Furthermore, results of fluorescence-activated cell sorting (FACS) analysis suggested that 12e induced cell cycle arrest in the G2/M phase accompanied by apoptosis in HL-60 and H460 cells. This action was confirmed by Hoechst staining and caspase-3 activation. Due to their easy synthesis and remarkable biological activities, 4-phenylquinolin-2(1H)-one analogs (4-PQs) are promising new anticancer leads based on the quinoline scaffold. Accordingly, compound 12e was identified as a new lead compound that merits further optimization and development as an anticancer candidate.

  3. Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2.

    PubMed

    Chang, Che-Chien; Cao, Song; Kang, Soosung; Kai, Li; Tian, Xinyong; Pandey, Prativa; Dunne, Sara Fernandez; Luan, Chi-Hao; Surmeier, D James; Silverman, Richard B

    2010-05-01

    L-type Ca(2+) channels in mammalian brain neurons have either a Ca(V)1.2 or Ca(V)1.3 pore-forming subunit. Recently, it was shown that Ca(V)1.3 Ca(2+) channels underlie autonomous pacemaking in adult dopaminergic neurons in the substantia nigra pars compacta, and this reliance renders them sensitive to toxins used to create animal models of Parkinson's disease. Antagonism of these channels with the dihydropyridine antihypertensive drug isradipine diminishes the reliance on Ca(2+) and the sensitivity of these neurons to toxins, pointing to a potential neuroprotective strategy. However, for neuroprotection without an antihypertensive side effect, selective Ca(V)1.3 channel antagonists are required. In an attempt to identify potent and selective antagonists of Ca(V)1.3 channels, 124 dihydropyridines (4-substituted-1,4-dihydropyridine-3,5-dicarboxylic diesters) were synthesized. The antagonism of heterologously expressed Ca(V)1.2 and Ca(V)1.3 channels was then tested using electrophysiological approaches and the FLIPR Calcium 4 assay. Despite the large diversity in substitution on the dihydropyridine scaffold, the most Ca(V)1.3 selectivity was only about twofold. These results support a highly similar dihydropyridine binding site at both Ca(V)1.2 and Ca(V)1.3 channels and suggests that other classes of compounds need to be identified for Ca(V)1.3 selectivity.

  4. The EarthScope Portal

    NASA Astrophysics Data System (ADS)

    Baru, C.; Ahern, T.; Anderson, G.; Behrends, K.; Casey, R.; Hoyt, B.; Kamb, L.; Lin, K.; Meertens, C.; Memon, A.; Muench, J.; Stolte, C.; Weertman, B.; Weiland, C.

    2007-12-01

    The EarthScope Portal is being developed in order to provide a unified, single-point of access to EarthScope data products from USArray, PBO, and SAFOD experiments. The portal will feature basic search and data access capabilities to allow users to discover and access EarthScope data using spatial, temporal, and other metadata- based search conditions. In this presentation, we will describe the features and design of the portal, which is being developed by a team consisting of GEON (Geosciences Network, http://www.geongrid.org), IRIS, UNAVCO, and Stanford. The portal search module invokes Web services developed by IRIS, UNAVCO, and Stanford to search for EarthScope data in the archives at each of these locations. The Web services provide information about all resources (data) that match the specified search conditions. Users will be able to select from the returned data sets, add selected data to a "data cart", and request the selected data to be packaged for download to the user. The initial services being defined are for "station discovery", to find which stations are available for specified spatial and temporal bounds, and "data discovery", to find the data sets that are available from the stations. Users will subsequently be able to choose the specific datasets, which will be assembled in a user "workspace" and available for download. The EarthScope Portal leverages the significant portal development efforts of the GEON Project at the San Diego Supercomputer Center, SDSC (http://portal.geongrid.org), and the development of Web services interfaces at the three data archive facilities. The portal is implemented using the open source GridSphere portal software infrastructure which supports the well-known Java portlet interface, viz. JSR 168 or the Portlet API. It uses a set of "core" portlets that have been developed in GEON for Data Registration, Search, and Workspace Services. We will provide a report on the current state of development of the Portal. A

  5. The scope of forensic radiology.

    PubMed

    Brogdon, B G

    1998-06-01

    The use of x-ray in the solution of forensic problems commenced within days of Röntgen's discovery; indeed, most of the applications of radiology to the forensic sciences were accomplished or anticipated within the next two years. The scope of forensic radiology ranges widely and includes determination of identity, evaluation of injury and death, applications in both criminal and civil litigation and in administrative proceedings, detection of abuse, investigation of gunshot wounds, medical education and research. Newer modalities and techniques afford opportunity for the expansion of forensic radiology if problems of accessibility and cost can be resolved along with improvement in interdisciplinary cooperation and understanding.

  6. Beowulf Supercomputers: Scope and Trends

    NASA Astrophysics Data System (ADS)

    Ahmed, Maqsood; Saeed, M. Alam; Ahmed, Rashid; Fazal-e-Aleem

    2005-03-01

    As we have entered in twenty 1st century, a century of information technology, the need of supercomputing is expanding in many fields of science and technology. With the availability of low cost commodity hardware, free software, Beowulf style supercomputers have solved the problem of scientific community. The supercomputer helps in solving complex problems, store, process, and manage huge amount of scientific data available all over the globe. In this paper we have tried to discuss the functioning of Beowulf style supercomputer, its scope and future trends.

  7. Anticonvulsant Profiles of Certain New 6-Aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-Aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones

    PubMed Central

    Aboul-Enein, Mohamed N.; El-Azzouny, Aida A.; Attia, Mohamed I.; Maklad, Yousreya A.; Aboutabl, Mona E.; Ragab, Fatma; El-Hamid, Walaa H. A. Abd

    2014-01-01

    Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a–l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones (6m–x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino]cycloalkanecarboxamides (3a–f) were prepared via adopting Strecker synthesis on the proper cycloalkanone followed by partial hydrolysis of the obtained nitrile functionality and subsequent N-cyanomethylation. Compounds 3a–f were subjected to complete nitrile hydrolysis to give the respective carboxylic acid derivatives 4a–f which were cyclized under mild conditions to give the spiro compounds 5a–f. Ultimately, compounds 5a–f were alkylated or aralkylated to give the target compounds 6a–i and 6m–u. On the other hand, compounds 6j–l and 6v–x were synthesized from the intermediates 5a–f through alkylation, dehydration and finally tetrazole ring formation. Anticonvulsant screening of the target compounds 6a–x revealed that compound 6g showed an ED50 of 0.0043 mmol/kg in the scPTZ screen, being about 14 and 214 fold more potent than the reference drugs, Phenobarbital (ED50 = 0.06 mmol/kg) and Ethosuximide (ED50 = 0.92 mmol/kg), respectively. Compound 6e exhibited an ED50 of 0.019 mmol/kg, being about 1.8 fold more potent than that of the reference drug, Diphenylhydantoin (ED50 = 0.034 mmol/kg) in the MES screen. Interestingly, all the test compounds 6a–x did not show any minimal motor impairment at the maximum administered dose in the neurotoxicity screen. PMID:25250910

  8. Novel 4-Substituted-N,N-dimethyltetrahydronaphthalen-2-amines: Synthesis, Affinity, and In Silico Docking Studies at Serotonin 5-HT2-type and Histamine H1 G Protein-Coupled Receptors

    PubMed Central

    Sakhuja, Rajeev; Kondabolu, Krishnakanth; Córdova-Sintjago, Tania; Travers, Sean; Vincek, Adam S.; Kim, Myong Sang; Abboud, Khalil A.; Fang, Lijuan; Sun, Zhuming; Canal, Clinton E.; Booth, Raymond G.

    2015-01-01

    Syntheses were undertaken of derivatives of (2S, 4R)-(−)-trans-4-phenyl-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine (4-phenyl-2-dimethylaminotetralin, PAT), a stereospecific agonist at the serotonin 5-HT2C G protein-coupled receptor (GPCR), with inverse agonist activity at 5-HT2A and 5-HT2B GPCRs. Molecular changes were made at the PAT C(4)-position, while preserving N, N-dimethyl substitution at the 2-position as well as trans-stereochemistry, structural features previously shown to be optimal for 5-HT2 binding. Affinities of analogs were determined at recombinant human 5-HT2 GPCRs in comparison to the phylogenetically closely-related histamine H1 GPCR, and in silico ligand docking studies were conducted at receptor molecular models to help interpret pharmacological results and guide future ligand design. In most cases, C(4)-substituted PAT analogs exhibited the same stereoselectivity ([−]-trans > [+]-trans) as the parent PAT across 5-HT2 and H1 GPCRs, albeit, with variable receptor selectivity. 4-(4′-substituted)-PAT analogs, however, demonstrated reversed stereoselectivity ([2S, 4R]-[+]-trans > [2S, 4R]-[−]-trans), with absolute configuration confirmed by single X-ray crystallographic data for the 4-(4′-Cl)-PAT analog. Pharmacological affinity results and computational results herein support further PAT drug development studies and provide a basis for predicting and interpreting translational results, including, for (+)-trans-4-(4′-Cl)-PAT and (−)-trans-4-(3′-Br)-PAT that were previously shown to be more potent and efficacious than their corresponding enantiomers in rodent models of psychoses, psychostimulant-induced behaviors, and compulsive feeding (‘binge-eating’). PMID:25703249

  9. Structure-property relationship of 3-(4-substituted benzyl)-1,3-diazaspiro[4.4]nonane-2,4-diones as new potentional anticonvulsant agents. An experimental and theoretical study

    NASA Astrophysics Data System (ADS)

    Lazić, Anita M.; Božić, Bojan Đ.; Vitnik, Vesna D.; Vitnik, Željko J.; Rogan, Jelena R.; Radovanović, Lidija D.; Valentić, Nataša V.; Ušćumlić, Gordana S.

    2017-01-01

    The structure-property relationship of newly synthesized 3-(4-substituted benzyl)-1,3-diazaspiro [4.4]nonane-2,4-diones was studied by experimental and calculated methods. The prepared compounds were characterized by UV-Vis, FT-IR, 1H NMR and 13C NMR spectroscopy and elemental analysis. The crystal structure was elucidated by single-crystal X-ray diffraction. The 3-benzyl-1,3-diazaspiro[4.4]nonane-2,4-dione crystallizes in triclinic P-1 space group, with two crystallographically independent molecules in the asymmetric unit. Cyclopentane ring adopts an envelope conformation. A three-dimensional crystal packing is governed by hydrogen N-H⋯O bonds, numerous C-H⋯O/N and C-H … π interactions between neighboring molecules. Density functional theory (DFT) calculations with B3LYP and M06-2X methods using 6-311++G(d,p) basis set were performed to provide structural and spectroscopic information. Comparisons between experimental and calculated UV-Vis spectral properties suggest that the monomeric form of the investigated spirohydantoins is dominant in all used solvents. The effects of substituents on the absorption spectra of spirohydantoins are interpreted by correlation of absorption frequencies with Hammett equation. The lipophilicities of the investigated molecules were estimated by calculation of their log P values. Some of the spirohydantoins synthesized in this work, exhibit the lipophilicities comparable to the standard medicine anticonvulsant drug Phenytoin. The results obtained in this investigation afford guidelines for the preparation of new derivatives of spirohydantoin as potential anticonvulsant agents and for better understanding the structure-activity relationship.

  10. Anticonvulsant profiles of certain new 6-aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones.

    PubMed

    Aboul-Enein, Mohamed N; El-Azzouny, Aida A; Attia, Mohamed I; Maklad, Yousreya A; Aboutabl, Mona E; Ragab, Fatma; Abd El-Hamid, Walaa H A

    2014-09-23

    Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a-l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5] undecane-3,5-diones (6m-x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino] cycloalkanecarboxamides (3a-f) were prepared via adopting Strecker synthesis on the proper cycloalkanone followed by partial hydrolysis of the obtained nitrile functionality and subsequent N-cyanomethylation. Compounds 3a-f were subjected to complete nitrile hydrolysis to give the respective carboxylic acid derivatives 4a-f which were cyclized under mild conditions to give the spiro compounds 5a-f. Ultimately, compounds 5a-f were alkylated or aralkylated to give the target compounds 6a-i and 6m-u. On the other hand, compounds 6j-l and 6v-x were synthesized from the intermediates 5a-f through alkylation, dehydration and finally tetrazole ring formation. Anticonvulsant screening of the target compounds 6a-x revealed that compound 6g showed an ED50 of 0.0043 mmol/kg in the scPTZ screen, being about 14 and 214 fold more potent than the reference drugs, Phenobarbital (ED50 = 0.06 mmol/kg) and Ethosuximide (ED50 = 0.92 mmol/kg), respectively. Compound 6e exhibited an ED50 of 0.019 mmol/kg, being about 1.8 fold more potent than that of the reference drug, Diphenylhydantoin (ED50 = 0.034 mmol/kg) in the MES screen. Interestingly, all the test compounds 6a-x did not show any minimal motor impairment at the maximum administered dose in the neurotoxicity screen.

  11. IDC Reengineering Phase 2 Project Scope.

    SciTech Connect

    Harris, James M.

    2015-02-01

    This report provides a brief description of the scope of the IDC Reengineering Phase 2 project. It describes the goals and objectives of reengineering, the system definition, and the technical scope of the system. REVISIONS Version Date Author/Team Revision Description Authorized by 1.0 9/25/2014 SNL IDC Reengineering Team Unlimited Release for I2 M. Harris 1.1 28/01/2015 IDC Reengineering Team Align with previous IDC scope document E. Tomuta.

  12. 77 FR 63309 - Constitution Pipeline Company, LLC; Notice of Public Scoping Meeting and Extension of Scoping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... Energy Regulatory Commission Constitution Pipeline Company, LLC; Notice of Public Scoping Meeting and... Energy Regulatory Commission (FERC or Commission) will hold an additional public scoping meeting for Constitution Pipeline Company's (Constitution) Constitution Pipeline Project. This notice also extends the...

  13. 49 CFR 192.351 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Customer Meters, Service Regulators, and Service Lines § 192.351 Scope. This subpart prescribes minimum requirements for installing customer meters,...

  14. 49 CFR 192.351 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Customer Meters, Service Regulators, and Service Lines § 192.351 Scope. This subpart prescribes minimum requirements for installing customer meters,...

  15. 49 CFR 192.351 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Customer Meters, Service Regulators, and Service Lines § 192.351 Scope. This subpart prescribes minimum requirements for installing customer meters,...

  16. 49 CFR 192.351 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Customer Meters, Service Regulators, and Service Lines § 192.351 Scope. This subpart prescribes minimum requirements for installing customer meters,...

  17. 49 CFR 192.351 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Customer Meters, Service Regulators, and Service Lines § 192.351 Scope. This subpart prescribes minimum requirements for installing customer meters,...

  18. 46 CFR 160.077-1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... APPROVAL LIFESAVING EQUIPMENT Hybrid Inflatable Personal Flotation Devices § 160.077-1 Scope. (a) This specification contains requirements for approving hybrid inflatable personal flotation devices (hybrid PFDs)....

  19. Remediation Optimization: Definition, Scope and Approach

    EPA Pesticide Factsheets

    This document provides a general definition, scope and approach for conducting optimization reviews within the Superfund Program and includes the fundamental principles and themes common to optimization.

  20. 7 CFR 110.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS RECORDKEEPING ON RESTRICTED USE PESTICIDES BY CERTIFIED APPLICATORS; SURVEYS AND REPORTS § 110.1 Scope. This...

  1. 7 CFR 110.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS RECORDKEEPING ON RESTRICTED USE PESTICIDES BY CERTIFIED APPLICATORS; SURVEYS AND REPORTS § 110.1 Scope. This...

  2. 30 CFR 820.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PERFORMANCE STANDARDS SPECIAL PERMANENT PROGRAM PERFORMANCE STANDARDS-ANTHRACITE MINES IN PENNSYLVANIA § 820.1 Scope. This part sets forth environmental protection performance standards for anthracite surface...

  3. 30 CFR 820.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PERFORMANCE STANDARDS SPECIAL PERMANENT PROGRAM PERFORMANCE STANDARDS-ANTHRACITE MINES IN PENNSYLVANIA § 820.1 Scope. This part sets forth environmental protection performance standards for anthracite surface...

  4. 30 CFR 820.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PERFORMANCE STANDARDS SPECIAL PERMANENT PROGRAM PERFORMANCE STANDARDS-ANTHRACITE MINES IN PENNSYLVANIA § 820.1 Scope. This part sets forth environmental protection performance standards for anthracite surface...

  5. 30 CFR 820.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PERFORMANCE STANDARDS SPECIAL PERMANENT PROGRAM PERFORMANCE STANDARDS-ANTHRACITE MINES IN PENNSYLVANIA § 820.1 Scope. This part sets forth environmental protection performance standards for anthracite surface...

  6. 30 CFR 820.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PERFORMANCE STANDARDS SPECIAL PERMANENT PROGRAM PERFORMANCE STANDARDS-ANTHRACITE MINES IN PENNSYLVANIA § 820.1 Scope. This part sets forth environmental protection performance standards for anthracite surface...

  7. 42 CFR 456.150 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals § 456.150 Scope. This subpart prescribes requirements for control of utilization of inpatient services in mental hospitals, including...

  8. 16 CFR § 1102.4 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AVAILABLE CONSUMER PRODUCT SAFETY INFORMATION DATABASE Background and Definitions § 1102.4 Scope. This part... Product Safety Information Database, including all information published therein. ...

  9. 42 CFR 456.150 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals § 456.150 Scope. This subpart prescribes requirements for control of utilization of inpatient services in mental hospitals, including...

  10. 42 CFR 456.150 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals § 456.150 Scope. This subpart prescribes requirements for control of utilization of inpatient services in mental hospitals, including...

  11. 42 CFR 456.150 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals § 456.150 Scope. This subpart prescribes requirements for control of utilization of inpatient services in mental hospitals, including...

  12. 42 CFR 456.150 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals § 456.150 Scope. This subpart prescribes requirements for control of utilization of inpatient services in mental hospitals, including...

  13. 16 CFR 1102.4 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CONSUMER PRODUCT SAFETY INFORMATION DATABASE (Eff. Jan. 10, 2011) Background and Definitions § 1102.4 Scope... Available Consumer Product Safety Information Database, including all information published therein....

  14. A Scoping Review of Scoping Reviews: Advancing the Approach and Enhancing the Consistency

    ERIC Educational Resources Information Center

    Pham, Mai T.; Rajic, Andrijana; Greig, Judy D.; Sargeant, Jan M.; Papadopoulos, Andrew; McEwen, Scott A.

    2014-01-01

    Background: The scoping review has become an increasingly popular approach for synthesizing research evidence. It is a relatively new approach for which a universal study definition or definitive procedure has not been established. The purpose of this scoping review was to provide an overview of scoping reviews in the literature. Methods: A…

  15. A Scoping Review of Scoping Reviews: Advancing the Approach and Enhancing the Consistency

    ERIC Educational Resources Information Center

    Pham, Mai T.; Rajic, Andrijana; Greig, Judy D.; Sargeant, Jan M.; Papadopoulos, Andrew; McEwen, Scott A.

    2014-01-01

    Background: The scoping review has become an increasingly popular approach for synthesizing research evidence. It is a relatively new approach for which a universal study definition or definitive procedure has not been established. The purpose of this scoping review was to provide an overview of scoping reviews in the literature. Methods: A…

  16. A scoping review on the conduct and reporting of scoping reviews.

    PubMed

    Tricco, Andrea C; Lillie, Erin; Zarin, Wasifa; O'Brien, Kelly; Colquhoun, Heather; Kastner, Monika; Levac, Danielle; Ng, Carmen; Sharpe, Jane Pearson; Wilson, Katherine; Kenny, Meghan; Warren, Rachel; Wilson, Charlotte; Stelfox, Henry T; Straus, Sharon E

    2016-02-09

    Scoping reviews are used to identify knowledge gaps, set research agendas, and identify implications for decision-making. The conduct and reporting of scoping reviews is inconsistent in the literature. We conducted a scoping review to identify: papers that utilized and/or described scoping review methods; guidelines for reporting scoping reviews; and studies that assessed the quality of reporting of scoping reviews. We searched nine electronic databases for published and unpublished literature scoping review papers, scoping review methodology, and reporting guidance for scoping reviews. Two independent reviewers screened citations for inclusion. Data abstraction was performed by one reviewer and verified by a second reviewer. Quantitative (e.g. frequencies of methods) and qualitative (i.e. content analysis of the methods) syntheses were conducted. After searching 1525 citations and 874 full-text papers, 516 articles were included, of which 494 were scoping reviews. The 494 scoping reviews were disseminated between 1999 and 2014, with 45% published after 2012. Most of the scoping reviews were conducted in North America (53%) or Europe (38%), and reported a public source of funding (64%). The number of studies included in the scoping reviews ranged from 1 to 2600 (mean of 118). Using the Joanna Briggs Institute methodology guidance for scoping reviews, only 13% of the scoping reviews reported the use of a protocol, 36% used two reviewers for selecting citations for inclusion, 29% used two reviewers for full-text screening, 30% used two reviewers for data charting, and 43% used a pre-defined charting form. In most cases, the results of the scoping review were used to identify evidence gaps (85%), provide recommendations for future research (84%), or identify strengths and limitations (69%). We did not identify any guidelines for reporting scoping reviews or studies that assessed the quality of scoping review reporting. The number of scoping reviews conducted per year

  17. 10 CFR 76.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Scope. 76.2 Section 76.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.2 Scope. The regulations in this part apply only to those portions of the Portsmouth and Paducah Gaseous Diffusion...

  18. 10 CFR 76.2 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Scope. 76.2 Section 76.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.2 Scope. The regulations in this part apply only to those portions of the Portsmouth and Paducah Gaseous Diffusion...

  19. 10 CFR 76.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Scope. 76.2 Section 76.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.2 Scope. The regulations in this part apply only to those portions of the Portsmouth and Paducah Gaseous Diffusion...

  20. 10 CFR 76.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Scope. 76.2 Section 76.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.2 Scope. The regulations in this part apply only to those portions of the Portsmouth and Paducah Gaseous Diffusion...

  1. 10 CFR 76.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Scope. 76.2 Section 76.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.2 Scope. The regulations in this part apply only to those portions of the Portsmouth and Paducah Gaseous Diffusion...

  2. 47 CFR 90.31 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Scope. 90.31 Section 90.31 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Industrial/Business Radio Pool § 90.31 Scope. The Industrial/Business Radio Pool covers the...

  3. 47 CFR 90.31 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Scope. 90.31 Section 90.31 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Industrial/Business Radio Pool § 90.31 Scope. The Industrial/Business Radio Pool covers the...

  4. 47 CFR 90.31 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Scope. 90.31 Section 90.31 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Industrial/Business Radio Pool § 90.31 Scope. The Industrial/Business Radio Pool covers the...

  5. 47 CFR 90.31 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Scope. 90.31 Section 90.31 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Industrial/Business Radio Pool § 90.31 Scope. The Industrial/Business Radio Pool covers the...

  6. 47 CFR 90.31 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Scope. 90.31 Section 90.31 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Industrial/Business Radio Pool § 90.31 Scope. The Industrial/Business Radio Pool covers the...

  7. 48 CFR 2905.501 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Scope. 2905.501 Section 2905.501 Federal Acquisition Regulations System DEPARTMENT OF LABOR ACQUISITION PLANNING PUBLICIZING CONTRACT ACTIONS Paid Advertisements 2905.501 Scope. This subpart provides policies and procedures for the...

  8. 17 CFR 34.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Scope. 34.1 Section 34.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION REGULATION OF HYBRID INSTRUMENTS § 34.1 Scope. The provisions of this part shall apply to any hybrid instrument which may be subject...

  9. 17 CFR 34.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Scope. 34.1 Section 34.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION REGULATION OF HYBRID INSTRUMENTS § 34.1 Scope. The provisions of this part shall apply to any hybrid instrument which may be subject...

  10. 17 CFR 34.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Scope. 34.1 Section 34.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION REGULATION OF HYBRID INSTRUMENTS § 34.1 Scope. The provisions of this part shall apply to any hybrid instrument which may be subject...

  11. 17 CFR 34.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Scope. 34.1 Section 34.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION REGULATION OF HYBRID INSTRUMENTS § 34.1 Scope. The provisions of this part shall apply to any hybrid instrument which may be subject...

  12. 17 CFR 34.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Scope. 34.1 Section 34.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION REGULATION OF HYBRID INSTRUMENTS § 34.1 Scope. The provisions of this part shall apply to any hybrid instrument which may be subject...

  13. 40 CFR 56.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 6 2014-07-01 2014-07-01 false Scope. 56.2 Section 56.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGIONAL CONSISTENCY § 56.2 Scope. This part covers actions taken by: (a) Employees in EPA Regional Offices, including...

  14. 49 CFR 538.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 6 2014-10-01 2014-10-01 false Scope. 538.1 Section 538.1 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION MANUFACTURING INCENTIVES FOR ALTERNATIVE FUEL VEHICLES § 538.1 Scope. This part...

  15. 49 CFR 538.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Scope. 538.1 Section 538.1 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION MANUFACTURING INCENTIVES FOR ALTERNATIVE FUEL VEHICLES § 538.1 Scope. This part...

  16. 49 CFR 538.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 6 2013-10-01 2013-10-01 false Scope. 538.1 Section 538.1 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION MANUFACTURING INCENTIVES FOR ALTERNATIVE FUEL VEHICLES § 538.1 Scope. This part...

  17. 49 CFR 538.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 6 2011-10-01 2011-10-01 false Scope. 538.1 Section 538.1 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION MANUFACTURING INCENTIVES FOR ALTERNATIVE FUEL VEHICLES § 538.1 Scope. This part...

  18. 49 CFR 538.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 6 2012-10-01 2012-10-01 false Scope. 538.1 Section 538.1 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION MANUFACTURING INCENTIVES FOR ALTERNATIVE FUEL VEHICLES § 538.1 Scope. This part...

  19. 18 CFR 1b.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Scope. 1b.2 Section 1b.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.2 Scope. This part applies to investigations...

  20. 18 CFR 1b.2 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Scope. 1b.2 Section 1b.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.2 Scope. This part applies to investigations...

  1. 18 CFR 1b.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Scope. 1b.2 Section 1b.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.2 Scope. This part applies to investigations...

  2. 18 CFR 1b.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Scope. 1b.2 Section 1b.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.2 Scope. This part applies to investigations...

  3. 18 CFR 401.31 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Scope. 401.31 Section 401.31 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Project Review Under Section 3.8 of the Compact § 401.31 Scope. This...

  4. 18 CFR 401.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Scope. 401.1 Section 401.1 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Comprehensive Plan § 401.1 Scope. This subpart shall govern the...

  5. 18 CFR 401.21 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Scope. 401.21 Section 401.21 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Water Resources Program § 401.21 Scope. This subpart shall govern the...

  6. 50 CFR 270.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Scope. 270.1 Section 270.1 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISH AND SEAFOOD PROMOTION SPECIES-SPECIFIC SEAFOOD MARKETING COUNCILS § 270.1 Scope. This...

  7. 47 CFR 1.1303 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Scope. 1.1303 Section 1.1303 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Procedures Implementing the National Environmental Policy Act of 1969 § 1.1303 Scope. The provisions of this subpart shall apply to all...

  8. 21 CFR 58.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Scope. 58.1 Section 58.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES General Provisions § 58.1 Scope. (a) This part prescribes good...

  9. 21 CFR 58.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Scope. 58.1 Section 58.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES General Provisions § 58.1 Scope. (a) This part prescribes good...

  10. 21 CFR 58.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Scope. 58.1 Section 58.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES General Provisions § 58.1 Scope. (a) This part prescribes good...

  11. 21 CFR 58.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Scope. 58.1 Section 58.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES General Provisions § 58.1 Scope. (a) This part prescribes good...

  12. 21 CFR 58.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Scope. 58.1 Section 58.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES General Provisions § 58.1 Scope. (a) This part prescribes good...

  13. 21 CFR 1141.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Scope. 1141.1 Section 1141.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) TOBACCO PRODUCTS CIGARETTE PACKAGE AND ADVERTISING WARNINGS General Provisions § 1141.1 Scope. (a) This part sets forth the...

  14. 21 CFR 1141.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Scope. 1141.1 Section 1141.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) TOBACCO PRODUCTS CIGARETTE PACKAGE AND ADVERTISING WARNINGS; (Eff. 9-22-12) General Provisions § 1141.1 Scope. (a) This part...

  15. 10 CFR 707.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope. 707.2 Section 707.2 Energy DEPARTMENT OF ENERGY WORKPLACE SUBSTANCE ABUSE PROGRAMS AT DOE SITES General Provisions § 707.2 Scope. (a) This part applies to the following contracts with DOE, at sites owned or controlled by DOE which are operated under...

  16. 10 CFR 707.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Scope. 707.2 Section 707.2 Energy DEPARTMENT OF ENERGY WORKPLACE SUBSTANCE ABUSE PROGRAMS AT DOE SITES General Provisions § 707.2 Scope. (a) This part applies to the following contracts with DOE, at sites owned or controlled by DOE which are operated under...

  17. 10 CFR 707.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope. 707.2 Section 707.2 Energy DEPARTMENT OF ENERGY WORKPLACE SUBSTANCE ABUSE PROGRAMS AT DOE SITES General Provisions § 707.2 Scope. (a) This part applies to the following contracts with DOE, at sites owned or controlled by DOE which are operated under...

  18. 10 CFR 707.2 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Scope. 707.2 Section 707.2 Energy DEPARTMENT OF ENERGY WORKPLACE SUBSTANCE ABUSE PROGRAMS AT DOE SITES General Provisions § 707.2 Scope. (a) This part applies to the following contracts with DOE, at sites owned or controlled by DOE which are operated under...

  19. 10 CFR 707.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Scope. 707.2 Section 707.2 Energy DEPARTMENT OF ENERGY WORKPLACE SUBSTANCE ABUSE PROGRAMS AT DOE SITES General Provisions § 707.2 Scope. (a) This part applies to the following contracts with DOE, at sites owned or controlled by DOE which are operated under...

  20. 31 CFR 8.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Scope. 8.1 Section 8.1 Money and Finance: Treasury Office of the Secretary of the Treasury PRACTICE BEFORE THE BUREAU OF ALCOHOL, TOBACCO AND FIREARMS General Requirements § 8.1 Scope. This part contains rules governing the recognition of...

  1. 31 CFR 8.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Scope. 8.1 Section 8.1 Money and Finance: Treasury Office of the Secretary of the Treasury PRACTICE BEFORE THE BUREAU OF ALCOHOL, TOBACCO AND FIREARMS General Requirements § 8.1 Scope. This part contains rules governing the recognition of...

  2. 49 CFR 8.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Scope. 8.1 Section 8.1 Transportation Office of the Secretary of Transportation CLASSIFIED INFORMATION: CLASSIFICATION/DECLASSIFICATION/ACCESS General § 8.1 Scope. This part sets forth procedures for the classification, declassification, and...

  3. 10 CFR 1016.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope. 1016.2 Section 1016.2 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SAFEGUARDING OF RESTRICTED DATA General Provisions § 1016.2 Scope. The regulations in this part apply to all persons who may require access to Retricted Data used, processed, stored...

  4. 9 CFR 124.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Scope. 124.1 Section 124.1 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS... Scope. (a) This parts sets forth procedures and requirements for APHIS review of applications for the...

  5. 9 CFR 124.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Scope. 124.1 Section 124.1 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS... Scope. (a) This parts sets forth procedures and requirements for APHIS review of applications for the...

  6. 14 CFR 171.151 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Scope. 171.151 Section 171.151 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Distance Measuring Equipment (DME) § 171.151 Scope. This subpart...

  7. 47 CFR 1.1601 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Scope. 1.1601 Section 1.1601 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Random Selection Procedures for Mass Media Services General Procedures § 1.1601 Scope. The provisions of this subpart, and the provisions...

  8. 47 CFR 1.821 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Scope. 1.821 Section 1.821 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Complaints, Applications, Tariffs, and Reports Involving Common Carriers Grants by Random Selection § 1.821 Scope. The provisions of §§ 1.822 and...

  9. 17 CFR 36.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Scope. 36.1 Section 36.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXEMPT MARKETS § 36.1 Scope. The provisions of this part apply to any board of trade or electronic trading facility eligible for exemption...

  10. Scope of practice in podiatric sports medicine.

    PubMed

    Ragley, P A

    1995-03-01

    The author discusses the issue of scope of practice in podiatric sports medicine and cases involving this area of practice, as well as the attendant ramifications. By gaining insight into this tissue, it is hoped the importance of practicing within the specific state scope of practice laws will be recognized.

  11. 10 CFR 100.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Scope. 100.2 Section 100.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) REACTOR SITE CRITERIA § 100.2 Scope. The siting requirements contained in this part... and testing reactors pursuant to the provisions of part 50 or part 52 of this chapter....

  12. 10 CFR 100.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Scope. 100.2 Section 100.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) REACTOR SITE CRITERIA § 100.2 Scope. The siting requirements contained in this part... and testing reactors pursuant to the provisions of part 50 or part 52 of this chapter....

  13. 10 CFR 51.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS § 51.1 Scope. This part contains environmental protection regulations applicable to NRC's domestic... within the scope of part 110 of this chapter or to any environmental effects which NRC's...

  14. 10 CFR 51.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS § 51.1 Scope. This part contains environmental protection regulations applicable to NRC's domestic... within the scope of part 110 of this chapter or to any environmental effects which NRC's...

  15. 49 CFR 215.201 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Scope. 215.201 Section 215.201 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.201 Scope. This subpart...

  16. 49 CFR 221.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Scope. 221.1 Section 221.1 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REAR END MARKING DEVICE-PASSENGER, COMMUTER AND FREIGHT TRAINS General § 221.1 Scope. This...

  17. 19 CFR 10.2001 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Scope. 10.2001 Section 10.2001 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES... Provisions § 10.2001 Scope. This subpart implements the duty preference and related customs...

  18. 12 CFR 747.2001 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Scope. 747.2001 Section 747.2001 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS ADMINISTRATIVE ACTIONS... Orders Imposing Prompt Corrective Action § 747.2001 Scope. (a) Independent review process. The rules...

  19. 12 CFR 747.2001 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Scope. 747.2001 Section 747.2001 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS ADMINISTRATIVE ACTIONS... Orders Imposing Prompt Corrective Action § 747.2001 Scope. (a) Independent review process. The rules...

  20. 12 CFR 747.2001 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Scope. 747.2001 Section 747.2001 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS ADMINISTRATIVE ACTIONS... Orders Imposing Prompt Corrective Action § 747.2001 Scope. (a) Independent review process. The rules...

  1. 12 CFR 747.2001 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Scope. 747.2001 Section 747.2001 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS ADMINISTRATIVE ACTIONS... Orders Imposing Prompt Corrective Action § 747.2001 Scope. (a) Independent review process. The rules...

  2. 12 CFR 747.2001 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Scope. 747.2001 Section 747.2001 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS ADMINISTRATIVE ACTIONS... Orders Imposing Prompt Corrective Action § 747.2001 Scope. (a) Independent review process. The rules...

  3. 49 CFR 213.51 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Scope. 213.51 Section 213.51 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Geometry § 213.51 Scope. This subpart prescribes requirements for the...

  4. 49 CFR 213.51 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Scope. 213.51 Section 213.51 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Geometry § 213.51 Scope. This subpart prescribes requirements for the...

  5. 49 CFR 213.51 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Scope. 213.51 Section 213.51 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Geometry § 213.51 Scope. This subpart prescribes requirements for the...

  6. 49 CFR 213.51 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Scope. 213.51 Section 213.51 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Geometry § 213.51 Scope. This subpart prescribes requirements for the...

  7. 18 CFR 401.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Scope. 401.1 Section 401.1 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Comprehensive Plan § 401.1 Scope. This subpart shall govern...

  8. 18 CFR 401.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Scope. 401.1 Section 401.1 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Comprehensive Plan § 401.1 Scope. This subpart shall govern...

  9. 18 CFR 401.21 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Scope. 401.21 Section 401.21 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Water Resources Program § 401.21 Scope. This subpart shall govern...

  10. 18 CFR 401.21 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Scope. 401.21 Section 401.21 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Water Resources Program § 401.21 Scope. This subpart shall govern...

  11. 18 CFR 401.21 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Scope. 401.21 Section 401.21 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Water Resources Program § 401.21 Scope. This subpart shall govern...

  12. 18 CFR 401.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Scope. 401.1 Section 401.1 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Comprehensive Plan § 401.1 Scope. This subpart shall govern...

  13. 45 CFR 96.80 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Scope. 96.80 Section 96.80 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Low-income Home Energy Assistance Program § 96.80 Scope. This subpart applies to the low-income home energy assistance program....

  14. 45 CFR 96.80 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Scope. 96.80 Section 96.80 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION BLOCK GRANTS Low-income Home Energy Assistance Program § 96.80 Scope. This subpart applies to the low-income home energy assistance program....

  15. 45 CFR 96.80 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Scope. 96.80 Section 96.80 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Low-income Home Energy Assistance Program § 96.80 Scope. This subpart applies to the low-income home energy assistance program....

  16. 45 CFR 96.80 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Scope. 96.80 Section 96.80 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Low-income Home Energy Assistance Program § 96.80 Scope. This subpart applies to the low-income home energy assistance program....

  17. 12 CFR 303.180 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Scope. 303.180 Section 303.180 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES International Banking § 303.180 Scope. This subpart sets forth procedures for complying with application...

  18. 40 CFR 56.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 5 2011-07-01 2011-07-01 false Scope. 56.2 Section 56.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGIONAL CONSISTENCY § 56.2 Scope. This part covers actions taken by: (a) Employees in EPA Regional Offices, including Regional...

  19. 48 CFR 970.1707-1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope. 970.1707-1 Section 970.1707-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Special Contracting Methods 970.1707-1 Scope. Pursuant to Section 33 of the Atomic Energy Act of 1954, as...

  20. 12 CFR 725.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Scope. 725.1 Section 725.1 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.1 Scope. This part contains the regulations implementing the National Credit Union Central Liquidity Facilit...

  1. 14 CFR 431.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Scope. 431.1 Section 431.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) General § 431.1 Scope. This part prescribes...

  2. 46 CFR 54.30-1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Scope. 54.30-1 Section 54.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Mechanical Stress Relief § 54.30-1 Scope. (a) Certain pressure vessels may be mechanically stress relieved in accordance with the...

  3. 46 CFR 54.30-1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Scope. 54.30-1 Section 54.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Mechanical Stress Relief § 54.30-1 Scope. (a) Certain pressure vessels may be mechanically stress relieved in accordance with the...

  4. 46 CFR 54.30-1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Scope. 54.30-1 Section 54.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Mechanical Stress Relief § 54.30-1 Scope. (a) Certain pressure vessels may be mechanically stress relieved in accordance with the...

  5. 10 CFR 1303.101 - Scope

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Scope 1303.101 Section 1303.101 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PUBLIC INFORMATION AND REQUESTS § 1303.101 Scope This part sets forth the policies and procedures of the U.S. Nuclear Waste Technical Review Board (Board) regarding public access...

  6. 10 CFR 1303.101 - Scope

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Scope 1303.101 Section 1303.101 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PUBLIC INFORMATION AND REQUESTS § 1303.101 Scope This part sets forth the policies and procedures of the U.S. Nuclear Waste Technical Review Board (Board) regarding public access...

  7. 10 CFR 1303.101 - Scope

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope 1303.101 Section 1303.101 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PUBLIC INFORMATION AND REQUESTS § 1303.101 Scope This part sets forth the policies and procedures of the U.S. Nuclear Waste Technical Review Board (Board) regarding public access...

  8. 10 CFR 1303.101 - Scope

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Scope 1303.101 Section 1303.101 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PUBLIC INFORMATION AND REQUESTS § 1303.101 Scope This part sets forth the policies and procedures of the U.S. Nuclear Waste Technical Review Board (Board) regarding public access...

  9. 30 CFR 723.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Scope. 723.1 Section 723.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR INITIAL PROGRAM REGULATIONS CIVIL PENALTIES § 723.1 Scope. This part covers the assessment of civil penalties under section 518 of the Act for violations of a...

  10. 30 CFR 700.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Scope. 700.1 Section 700.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR GENERAL GENERAL § 700.1 Scope. The regulations in chapter VII of 30 CFR, consisting of parts 700 through 899, establish the procedures through which the Secretary of...

  11. 30 CFR 722.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Scope. 722.1 Section 722.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR INITIAL PROGRAM REGULATIONS ENFORCEMENT PROCEDURES § 722.1 Scope. The regulations of this part set forth general procedures governing issuance of orders of...

  12. 30 CFR 920.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Scope. 920.1 Section 920.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROGRAMS FOR THE CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH STATE MARYLAND § 920.1 Scope. This part contains all rules applicable only within Maryland that have...

  13. 30 CFR 918.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Scope. 918.1 Section 918.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROGRAMS FOR THE CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH STATE LOUISIANA § 918.1 Scope. This part contains all rules applicable only within Louisiana which...

  14. 49 CFR 585.111 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Scope. 585.111 Section 585.111 Transportation... Reporting Requirements § 585.111 Scope. This subpart establishes requirements for manufacturers of passenger... kilograms (6,000 pounds) or less to submit a report, and maintain records related to the report, concerning...

  15. 42 CFR 51.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Scope. 51.1 Section 51.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO THE PROTECTION AND ADVOCACY FOR INDIVIDUALS WITH MENTAL ILLNESS PROGRAM § 51.1 Scope. The provisions of this part...

  16. 42 CFR 51.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Scope. 51.1 Section 51.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO THE PROTECTION AND ADVOCACY FOR INDIVIDUALS WITH MENTAL ILLNESS PROGRAM § 51.1 Scope. The provisions of this part...

  17. 42 CFR 51.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Scope. 51.1 Section 51.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO THE PROTECTION AND ADVOCACY FOR INDIVIDUALS WITH MENTAL ILLNESS PROGRAM § 51.1 Scope. The provisions of this part...

  18. 42 CFR 51.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Scope. 51.1 Section 51.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO THE PROTECTION AND ADVOCACY FOR INDIVIDUALS WITH MENTAL ILLNESS PROGRAM § 51.1 Scope. The provisions of this part...

  19. 42 CFR 51.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Scope. 51.1 Section 51.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO THE PROTECTION AND ADVOCACY FOR INDIVIDUALS WITH MENTAL ILLNESS PROGRAM § 51.1 Scope. The provisions of this part...

  20. 49 CFR 583.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Scope. 583.1 Section 583.1 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AUTOMOBILE PARTS CONTENT LABELING § 583.1 Scope. This part...

  1. 49 CFR 583.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Scope. 583.1 Section 583.1 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AUTOMOBILE PARTS CONTENT LABELING § 583.1 Scope. This part...

  2. 49 CFR 583.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Scope. 583.1 Section 583.1 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AUTOMOBILE PARTS CONTENT LABELING § 583.1 Scope. This part...

  3. 49 CFR 583.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Scope. 583.1 Section 583.1 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AUTOMOBILE PARTS CONTENT LABELING § 583.1 Scope. This part...

  4. 41 CFR 128-1.8000 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Scope. 128-1.8000 Section 128-1.8000 Public Contracts and Property Management Federal Property Management Regulations System (Continued) DEPARTMENT OF JUSTICE 1-INTRODUCTION 1.80-Seismic Safety Program § 128-1.8000 Scope. This subpart...

  5. 12 CFR 1412.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Scope. 1412.1 Section 1412.1 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION GOLDEN PARACHUTE AND INDEMNIFICATION PAYMENTS § 1412.1 Scope... (System) institutions, their service corporations, subsidiaries and affiliates from making...

  6. 12 CFR 1412.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Scope. 1412.1 Section 1412.1 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION GOLDEN PARACHUTE AND INDEMNIFICATION PAYMENTS § 1412.1 Scope... (System) institutions, their service corporations, subsidiaries and affiliates from making...

  7. 12 CFR 1412.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Scope. 1412.1 Section 1412.1 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION GOLDEN PARACHUTE AND INDEMNIFICATION PAYMENTS § 1412.1 Scope... (System) institutions, their service corporations, subsidiaries and affiliates from making...

  8. 12 CFR 1412.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Scope. 1412.1 Section 1412.1 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION GOLDEN PARACHUTE AND INDEMNIFICATION PAYMENTS § 1412.1 Scope... (System) institutions, their service corporations, subsidiaries and affiliates from making...

  9. 12 CFR 1412.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Scope. 1412.1 Section 1412.1 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION GOLDEN PARACHUTE AND INDEMNIFICATION PAYMENTS § 1412.1 Scope... (System) institutions, their service corporations, subsidiaries and affiliates from making...

  10. 32 CFR 989.18 - Scoping.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... help identify significant environmental issues to be analyzed in depth. Methods of scoping range from... de-emphasize insignificant issues and focus the scope of the environmental analysis on significant... Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ENVIRONMENTAL PROTECTION ENVIRONMENTAL...

  11. 10 CFR 55.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Scope. 55.2 Section 55.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES General Provisions § 55.2 Scope. The regulations in this part apply to— (a) Any individual who manipulates the controls of any utilization facility licensed...

  12. 10 CFR 830.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope. 830.1 Section 830.1 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT § 830.1 Scope. This part governs the conduct of DOE contractors, DOE personnel... affect, the safety of DOE nuclear facilities....

  13. 10 CFR 830.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope. 830.1 Section 830.1 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT § 830.1 Scope. This part governs the conduct of DOE contractors, DOE personnel... affect, the safety of DOE nuclear facilities....

  14. 10 CFR 55.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Scope. 55.2 Section 55.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES General Provisions § 55.2 Scope. The regulations in this part apply to— (a) Any individual who manipulates the controls of any utilization facility licensed...

  15. 10 CFR 1705.01 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope. 1705.01 Section 1705.01 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.01 Scope. This part contains the Board's regulations implementing the Privacy Act of 1974, Public Law 93-579, 5 U.S.C. 552a....

  16. 10 CFR 830.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Scope. 830.1 Section 830.1 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT § 830.1 Scope. This part governs the conduct of DOE contractors, DOE personnel... affect, the safety of DOE nuclear facilities....

  17. 10 CFR 1705.01 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope. 1705.01 Section 1705.01 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.01 Scope. This part contains the Board's regulations implementing the Privacy Act of 1974, Public Law 93-579, 5 U.S.C. 552a....

  18. 10 CFR 1705.01 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Scope. 1705.01 Section 1705.01 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.01 Scope. This part contains the Board's regulations implementing the Privacy Act of 1974, Public Law 93-579, 5 U.S.C. 552a....

  19. 10 CFR 830.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Scope. 830.1 Section 830.1 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT § 830.1 Scope. This part governs the conduct of DOE contractors, DOE personnel... affect, the safety of DOE nuclear facilities....

  20. 10 CFR 1705.01 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Scope. 1705.01 Section 1705.01 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.01 Scope. This part contains the Board's regulations implementing the Privacy Act of 1974, Public Law 93-579, 5 U.S.C. 552a....

  1. 10 CFR 100.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Scope. 100.2 Section 100.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) REACTOR SITE CRITERIA § 100.2 Scope. The siting requirements contained in this part apply to applications for site approval for the purpose of constructing and operating stationary...

  2. 10 CFR 830.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Scope. 830.1 Section 830.1 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT § 830.1 Scope. This part governs the conduct of DOE contractors, DOE personnel... affect, the safety of DOE nuclear facilities....

  3. 18 CFR 401.31 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Scope. 401.31 Section 401.31 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Project Review Under Section 3.8 of the Compact § 401.31 Scope. This...

  4. 18 CFR 401.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Scope. 401.1 Section 401.1 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Comprehensive Plan § 401.1 Scope. This subpart shall govern the...

  5. 18 CFR 401.21 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Scope. 401.21 Section 401.21 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Water Resources Program § 401.21 Scope. This subpart shall govern the...

  6. 12 CFR 308.161 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Scope. 308.161 Section 308.161 Banks and... Where a Felony ls Charged § 308.161 Scope. The rules and procedures set forth in this subpart shall...: (1) A judgment of conviction or an agreement to enter a pre-trial diversion or other similar program...

  7. 50 CFR 520.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Scope. 520.2 Section 520.2 Wildlife and Fisheries MARINE MAMMAL COMMISSION PUBLIC AVAILABILITY OF AGENCY MATERIALS § 520.2 Scope. (a) These...) Interfere with enforcement proceedings, (ii) Deprive a person of a right to a fair trial or an impartial...

  8. 21 CFR 312.81 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 5 2011-04-01 2011-04-01 false Scope. 312.81 Section 312.81 Food and Drugs FOOD... § 312.81 Scope. This section applies to new drug and biological products that are being studied for... with potentially fatal outcomes, where the end point of clinical trial analysis is survival. (b) For...

  9. 21 CFR 601.90 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Scope. 601.90 Section 601.90 Food and Drugs FOOD... Approval of Biological Products When Human Efficacy Studies Are Not Ethical or Feasible § 601.90 Scope... permanently disabling toxic biological, chemical, radiological, or nuclear substance; and field trials to...

  10. 12 CFR 509.300 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Scope. 509.300 Section 509.300 Banks and... ADJUDICATORY PROCEEDINGS Exemptions under Section 19(e) of the FDIA § 509.300 Scope. The procedures in this... certain criminal offenses or who have agreed to enter into a pre-trial diversion or similar program in...

  11. 21 CFR 312.81 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 5 2014-04-01 2014-04-01 false Scope. 312.81 Section 312.81 Food and Drugs FOOD... § 312.81 Scope. This section applies to new drug and biological products that are being studied for... with potentially fatal outcomes, where the end point of clinical trial analysis is survival. (b) For...

  12. 21 CFR 314.600 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 5 2013-04-01 2013-04-01 false Scope. 314.600 Section 314.600 Food and Drugs FOOD... Ethical or Feasible § 314.600 Scope. This subpart applies to certain new drug products that have been... substance; and field trials to study the product's effectiveness after an accidental or hostile exposure...

  13. 21 CFR 312.81 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 5 2013-04-01 2013-04-01 false Scope. 312.81 Section 312.81 Food and Drugs FOOD... § 312.81 Scope. This section applies to new drug and biological products that are being studied for... with potentially fatal outcomes, where the end point of clinical trial analysis is survival. (b) For...

  14. 21 CFR 312.81 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Scope. 312.81 Section 312.81 Food and Drugs FOOD... § 312.81 Scope. This section applies to new drug and biological products that are being studied for... with potentially fatal outcomes, where the end point of clinical trial analysis is survival. (b) For...

  15. 21 CFR 314.600 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 5 2011-04-01 2011-04-01 false Scope. 314.600 Section 314.600 Food and Drugs FOOD... Ethical or Feasible § 314.600 Scope. This subpart applies to certain new drug products that have been... substance; and field trials to study the product's effectiveness after an accidental or hostile exposure...

  16. 12 CFR 308.161 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Scope. 308.161 Section 308.161 Banks and... Where a Felony ls Charged § 308.161 Scope. The rules and procedures set forth in this subpart shall...: (1) A judgment of conviction or an agreement to enter a pre-trial diversion or other similar program...

  17. 21 CFR 314.600 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 5 2012-04-01 2012-04-01 false Scope. 314.600 Section 314.600 Food and Drugs FOOD... Ethical or Feasible § 314.600 Scope. This subpart applies to certain new drug products that have been... substance; and field trials to study the product's effectiveness after an accidental or hostile exposure...

  18. 37 CFR 90.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... JUDICIAL REVIEW OF PATENT TRIAL AND APPEAL BOARD DECISIONS § 90.1 Scope. The provisions herein govern judicial review for Patent Trial and Appeal Board decisions under chapter 13 of title 35, United States... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Scope. 90.1 Section 90.1...

  19. 37 CFR 90.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... JUDICIAL REVIEW OF PATENT TRIAL AND APPEAL BOARD DECISIONS § 90.1 Scope. The provisions herein govern judicial review for Patent Trial and Appeal Board decisions under chapter 13 of title 35, United States... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Scope. 90.1 Section 90.1...

  20. 12 CFR 509.300 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Scope. 509.300 Section 509.300 Banks and... ADJUDICATORY PROCEEDINGS Exemptions under Section 19(e) of the FDIA § 509.300 Scope. The procedures in this... certain criminal offenses or who have agreed to enter into a pre-trial diversion or similar program in...

  1. 21 CFR 314.600 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Scope. 314.600 Section 314.600 Food and Drugs FOOD... Ethical or Feasible § 314.600 Scope. This subpart applies to certain new drug products that have been... substance; and field trials to study the product's effectiveness after an accidental or hostile exposure...

  2. 21 CFR 312.81 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 5 2012-04-01 2012-04-01 false Scope. 312.81 Section 312.81 Food and Drugs FOOD... § 312.81 Scope. This section applies to new drug and biological products that are being studied for... with potentially fatal outcomes, where the end point of clinical trial analysis is survival. (b) For...

  3. 21 CFR 601.90 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Scope. 601.90 Section 601.90 Food and Drugs FOOD... Approval of Biological Products When Human Efficacy Studies Are Not Ethical or Feasible § 601.90 Scope... permanently disabling toxic biological, chemical, radiological, or nuclear substance; and field trials to...

  4. 12 CFR 308.161 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Scope. 308.161 Section 308.161 Banks and... Where a Felony ls Charged § 308.161 Scope. The rules and procedures set forth in this subpart shall...: (1) A judgment of conviction or an agreement to enter a pre-trial diversion or other similar program...

  5. 12 CFR 509.300 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Scope. 509.300 Section 509.300 Banks and... ADJUDICATORY PROCEEDINGS Exemptions under Section 19(e) of the FDIA § 509.300 Scope. The procedures in this... certain criminal offenses or who have agreed to enter into a pre-trial diversion or similar program in...

  6. 21 CFR 314.600 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 5 2014-04-01 2014-04-01 false Scope. 314.600 Section 314.600 Food and Drugs FOOD... Ethical or Feasible § 314.600 Scope. This subpart applies to certain new drug products that have been... substance; and field trials to study the product's effectiveness after an accidental or hostile exposure...

  7. 21 CFR 601.90 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Scope. 601.90 Section 601.90 Food and Drugs FOOD... Approval of Biological Products When Human Efficacy Studies Are Not Ethical or Feasible § 601.90 Scope... permanently disabling toxic biological, chemical, radiological, or nuclear substance; and field trials to...

  8. 50 CFR 520.2 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Scope. 520.2 Section 520.2 Wildlife and Fisheries MARINE MAMMAL COMMISSION PUBLIC AVAILABILITY OF AGENCY MATERIALS § 520.2 Scope. (a) These...) Interfere with enforcement proceedings, (ii) Deprive a person of a right to a fair trial or an impartial...

  9. 50 CFR 520.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Scope. 520.2 Section 520.2 Wildlife and Fisheries MARINE MAMMAL COMMISSION PUBLIC AVAILABILITY OF AGENCY MATERIALS § 520.2 Scope. (a) These...) Interfere with enforcement proceedings, (ii) Deprive a person of a right to a fair trial or an impartial...

  10. 10 CFR 850.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope. 850.1 Section 850.1 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM General Provisions § 850.1 Scope. This part provides for establishment of a chronic beryllium disease prevention program (CBDPP) that supplements and is deemed an...

  11. 10 CFR 850.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Scope. 850.1 Section 850.1 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM General Provisions § 850.1 Scope. This part provides for establishment of a chronic beryllium disease prevention program (CBDPP) that supplements and is deemed an...

  12. 10 CFR 850.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Scope. 850.1 Section 850.1 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM General Provisions § 850.1 Scope. This part provides for establishment of a chronic beryllium disease prevention program (CBDPP) that supplements and is deemed an...

  13. 10 CFR 850.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Scope. 850.1 Section 850.1 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM General Provisions § 850.1 Scope. This part provides for establishment of a chronic beryllium disease prevention program (CBDPP) that supplements and is deemed an...

  14. 10 CFR 1303.101 - Scope

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope 1303.101 Section 1303.101 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PUBLIC INFORMATION AND REQUESTS § 1303.101 Scope This part sets forth the policies and procedures of the U.S. Nuclear Waste Technical Review Board (Board) regarding public access...

  15. 49 CFR 633.3 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... TRANSPORTATION PROJECT MANAGEMENT OVERSIGHT General Provisions § 633.3 Scope. This rule applies to a recipient of Federal financial assistance undertaking a major capital project using funds made available under: (a... 49 Transportation 7 2010-10-01 2010-10-01 false Scope. 633.3 Section 633.3 Transportation Other...

  16. 10 CFR 603.800 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope. 603.800 Section 603.800 Energy DEPARTMENT OF ENERGY... Administrative Matters § 603.800 Scope. This subpart addresses administrative matters that do not impose organization-wide requirements on a participant's financial management, property management, or purchasing...

  17. 2 CFR 220.10 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of a particular project. Provision for profit or other increment above cost is outside the scope of... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Scope. 220.10 Section 220.10 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET...

  18. 37 CFR 401.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Scope. 401.1 Section 401.1..., CONTRACTS, AND COOPERATIVE AGREEMENTS § 401.1 Scope. (a) Traditionally there have been no conditions imposed... sponsored project, it is clear that the ownership provisions of these regulations would remain applicable in...

  19. 12 CFR 108.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Scope. 108.1 Section 108.1 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 108.1 Scope. The rules in this part apply to hearings, which are exempt...

  20. 45 CFR 308.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Scope. 308.0 Section 308.0 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT ENFORCEMENT PROGRAM... REVIEW AND REPORT § 308.0 Scope. This part establishes standards and criteria for the State self...

  1. 12 CFR 328.0 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Scope. 328.0 Section 328.0 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY ADVERTISEMENT OF MEMBERSHIP § 328.0 Scope. Part 328 describes the official sign of the FDIC and prescribes its use by insured...

  2. 19 CFR 125.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 125.0 Section 125.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARTAGE AND LIGHTERAGE OF MERCHANDISE § 125.0 Scope. This part is concerned with cartage and lighterage of merchandise...

  3. 12 CFR 359.0 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Scope. 359.0 Section 359.0 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY GOLDEN PARACHUTE AND INDEMNIFICATION PAYMENTS § 359.0 Scope. (a) This part limits and/or prohibits, in certain circumstances, the...

  4. 19 CFR 112.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 112.0 Section 112.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARRIERS, CARTMEN, AND LIGHTERMEN § 112.0 Scope. This part sets forth regulations providing for the bonding of...

  5. 12 CFR 303.0 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Scope. 303.0 Section 303.0 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES § 303.0 Scope. (a) This part describes the procedures to be followed by both the FDIC and applicants with respect to...

  6. 19 CFR 118.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 118.0 Section 118.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CENTRALIZED EXAMINATION STATIONS § 118.0 Scope. This part sets forth regulations providing for the making of agreements...

  7. 12 CFR 359.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Scope. 359.0 Section 359.0 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY GOLDEN PARACHUTE AND INDEMNIFICATION PAYMENTS § 359.0 Scope. (a) This part limits and/or prohibits, in certain circumstances, the...

  8. 19 CFR 133.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 133.0 Section 133.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY TRADEMARKS, TRADE NAMES, AND COPYRIGHTS § 133.0 Scope. This part provides for the recordation of trademarks, trade...

  9. 19 CFR 123.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 123.0 Section 123.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS RELATIONS WITH CANADA AND MEXICO § 123.0 Scope. This part contains special regulations pertaining to Customs...

  10. 19 CFR 111.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 111.0 Section 111.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BROKERS § 111.0 Scope. This part sets forth regulations providing for the licensing of, and granting of permits...

  11. 12 CFR 329.0 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Scope. 329.0 Section 329.0 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY INTEREST ON DEPOSITS § 329.0 Scope. This part applies to any deposit which is payable by a bank within the States of the...

  12. 45 CFR 305.0 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Scope. 305.0 Section 305.0 Public Welfare..., STANDARDS, FINANCIAL INCENTIVES, AND PENALTIES § 305.0 Scope. This part implements the incentive system... implements Federal audit requirements under sections 409(a)(8) and 452(a)(4) of the Act. Sections 305.0...

  13. 19 CFR 122.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 122.0 Section 122.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS § 122.0 Scope. (a) Applicability. The regulations in this part relate to the entry and clearance...

  14. 12 CFR 329.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Scope. 329.0 Section 329.0 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY INTEREST ON DEPOSITS § 329.0 Scope. This part applies to any deposit which is payable by a bank within the States of the...

  15. 32 CFR 842.0 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Scope. 842.0 Section 842.0 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE CLAIMS AND LITIGATION ADMINISTRATIVE CLAIMS § 842.0 Scope. This part establishes standard policies and procedures for administratively processing...

  16. 19 CFR 134.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 134.0 Section 134.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING § 134.0 Scope. This part sets forth regulations implementing the country of origin marking...

  17. 12 CFR 328.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Scope. 328.0 Section 328.0 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY ADVERTISEMENT OF MEMBERSHIP § 328.0 Scope. Part 328 describes the official sign of the FDIC and prescribes its use by insured...

  18. 19 CFR 127.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 127.0 Section 127.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY GENERAL ORDER, UNCLAIMED, AND ABANDONED MERCHANDISE § 127.0 Scope. This part sets forth regulations pertaining to general...

  19. 45 CFR 305.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Scope. 305.0 Section 305.0 Public Welfare..., STANDARDS, FINANCIAL INCENTIVES, AND PENALTIES § 305.0 Scope. This part implements the incentive system... implements Federal audit requirements under sections 409(a)(8) and 452(a)(4) of the Act. Sections 305.0...

  20. 19 CFR 101.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 101.0 Section 101.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY GENERAL PROVISIONS § 101.0 Scope. This part sets forth general regulations governing the authority of Customs...

  1. 45 CFR 308.0 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Scope. 308.0 Section 308.0 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT ENFORCEMENT PROGRAM... REVIEW AND REPORT § 308.0 Scope. This part establishes standards and criteria for the State self...

  2. 20 CFR 901.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Scope. 901.0 Section 901.0 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES REGULATIONS GOVERNING THE PERFORMANCE OF ACTUARIAL SERVICES UNDER THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974 § 901.0 Scope. This part contains rules...

  3. 12 CFR 303.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Scope. 303.0 Section 303.0 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES § 303.0 Scope. (a) This part describes the procedures to be followed by both the FDIC and applicants with respect to...

  4. 19 CFR 128.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 128.0 Section 128.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY EXPRESS CONSIGNMENTS § 128.0 Scope. This part sets forth requirements and procedures for the clearance of imported...

  5. 19 CFR 113.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 113.0 Section 113.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BONDS § 113.0 Scope. This part sets forth the general requirements applicable to bonds. It contains the...

  6. 19 CFR 114.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 114.0 Section 114.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARNETS § 114.0 Scope. This part is concerned with the use of international Customs documents known as carnets. It also...

  7. 19 CFR 132.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 132.0 Section 132.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY QUOTAS § 132.0 Scope. This part sets forth rules and procedures applicable to quotas administered by Headquarters, U.S...

  8. 19 CFR 103.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope. 103.0 Section 103.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AVAILABILITY OF INFORMATION § 103.0 Scope. This part governs the production/disclosure of agency-maintained documents...

  9. Dietetic Scopes of Practice Across Canada.

    PubMed

    Selinger, Martina; Berenbaum, Shawna

    2015-06-01

    The purpose of this study was to explore the concept of scope of practice in dietetics in Canada. Using interpretative description methodology, data were collected through 4 phases. This article reports on phases I and IV. In phase I, 8 provincial dietetic regulatory bodies participated in semi-structured telephone interviews on dietetic scope of practice. Phase IV consisted of a document analysis of Canadian dietetic scope of practice statements. A review of dietetic statements found in legislation across Canada has shown considerable variability in terms of length, wording, and reference to specific practice areas. Phase I participant discussion focused on 3 concepts: creating a scope of practice, using a scope of practice, and perceived or expected outcomes of a scope of practice. Dietetic scopes of practice statements are a product of a complex multi-player process. The nature of provincial health care makes it unrealistic to expect similar dietetic scope of practice statements across all provinces. However, maintaining relationships between dietetic regulatory bodies can aid in the replication of ideas, best practices, and policies between provinces.

  10. 78 FR 9370 - Notice of Scope Rulings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-08

    ... not within the scope of the antidumping duty order; August 14, 2012. A-570-836: Glycine From the... Republic of China-origin technical or crude glycine further processed in India is within the scope of the.... Indah Kiat Pulp & Paper Tbk, and Paper Max, Ltd. (collectively ``APP''); (1) APP's Ningbo Fold packaging...

  11. 10 CFR 160.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Scope. 160.2 Section 160.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) TRESPASSING ON COMMISSION PROPERTY § 160.2 Scope. The regulations in this part apply... the Nuclear Regulatory Commission or in its custody which have been posted with a notice of...

  12. 20 CFR 602.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Scope. 602.2 Section 602.2 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR QUALITY CONTROL IN THE FEDERAL-STATE UNEMPLOYMENT INSURANCE SYSTEM General Provisions § 602.2 Scope. This part applies to all State laws approved by...

  13. 43 CFR 14.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Scope. 14.1 Section 14.1 Public Lands: Interior Office of the Secretary of the Interior PETITIONS FOR RULEMAKING § 14.1 Scope. This part prescribes procedures for the filing and consideration of petitions for rulemaking...

  14. 43 CFR 14.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Scope. 14.1 Section 14.1 Public Lands: Interior Office of the Secretary of the Interior PETITIONS FOR RULEMAKING § 14.1 Scope. This part prescribes procedures for the filing and consideration of petitions for rulemaking...

  15. 43 CFR 14.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Scope. 14.1 Section 14.1 Public Lands: Interior Office of the Secretary of the Interior PETITIONS FOR RULEMAKING § 14.1 Scope. This part prescribes procedures for the filing and consideration of petitions for rulemaking...

  16. 43 CFR 14.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Scope. 14.1 Section 14.1 Public Lands: Interior Office of the Secretary of the Interior PETITIONS FOR RULEMAKING § 14.1 Scope. This part prescribes procedures for the filing and consideration of petitions for rulemaking...

  17. 43 CFR 14.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Scope. 14.1 Section 14.1 Public Lands: Interior Office of the Secretary of the Interior PETITIONS FOR RULEMAKING § 14.1 Scope. This part prescribes procedures for the filing and consideration of petitions for rulemaking...

  18. 19 CFR 134.0 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Scope. 134.0 Section 134.0 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING § 134.0 Scope. This part sets forth regulations implementing the country of origin...

  19. 14 CFR 1216.100 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Scope. 1216.100 Section 1216.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ENVIRONMENTAL QUALITY Policy on Environmental Quality and Control § 1216.100 Scope. This subpart sets forth NASA policy on environmental quality and...

  20. 14 CFR 1216.100 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Scope. 1216.100 Section 1216.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ENVIRONMENTAL QUALITY Policy on Environmental Quality and Control § 1216.100 Scope. This subpart sets forth NASA policy on environmental quality...

  1. 14 CFR 1216.100 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Scope. 1216.100 Section 1216.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ENVIRONMENTAL QUALITY Policy on Environmental Quality and Control § 1216.100 Scope. This subpart sets forth NASA policy on environmental quality...

  2. 14 CFR 1216.100 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Scope. 1216.100 Section 1216.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ENVIRONMENTAL QUALITY Policy on Environmental Quality and Control § 1216.100 Scope. This subpart sets forth NASA policy on environmental quality...

  3. 14 CFR § 1216.100 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Scope. § 1216.100 Section § 1216.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ENVIRONMENTAL QUALITY Policy on Environmental Quality and Control § 1216.100 Scope. This subpart sets forth NASA policy on environmental quality...

  4. 10 CFR 436.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Scope. 436.1 Section 436.1 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS § 436.1 Scope. This part sets forth the rules for Federal energy management and planning programs to reduce Federal energy consumption and...

  5. 43 CFR 1601.0-7 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Scope. 1601.0-7 Section 1601.0-7 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) PLANNING, PROGRAMMING, BUDGETING Planning § 1601.0-7 Scope...

  6. 43 CFR 1601.0-7 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Scope. 1601.0-7 Section 1601.0-7 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) PLANNING, PROGRAMMING, BUDGETING Planning § 1601.0-7 Scope...

  7. 43 CFR 1601.0-7 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Scope. 1601.0-7 Section 1601.0-7 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) PLANNING, PROGRAMMING, BUDGETING Planning § 1601.0-7 Scope...

  8. 43 CFR 1601.0-7 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Scope. 1601.0-7 Section 1601.0-7 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) PLANNING, PROGRAMMING, BUDGETING Planning § 1601.0-7 Scope...

  9. 20 CFR 902.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Scope. 902.1 Section 902.1 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES RULES REGARDING AVAILABILITY OF INFORMATION § 902.1 Scope. This part is issued by the Joint Board for the Enrollment of Actuaries (the “Joint...

  10. 10 CFR 10.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Scope. 10.2 Section 10.2 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.2 Scope. The criteria...

  11. 10 CFR 10.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Scope. 10.2 Section 10.2 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.2 Scope. The criteria...

  12. 10 CFR 10.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Scope. 10.2 Section 10.2 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.2 Scope. The criteria...

  13. 10 CFR 10.2 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Scope. 10.2 Section 10.2 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.2 Scope. The criteria...

  14. 10 CFR 10.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Scope. 10.2 Section 10.2 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.2 Scope. The criteria...

  15. 48 CFR 3004.470-1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Within Industry 3004.470-1 Scope. This section implements DHS's policies for assuring the security of... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Scope. 3004.470-1 Section 3004.470-1 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY...

  16. 14 CFR 414.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Scope. 414.1 Section 414.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING SAFETY APPROVALS General § 414.1 Scope. This part establishes procedures for obtaining a...

  17. 14 CFR 415.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Scope. 415.1 Section 415.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.1 Scope. This part prescribes requirements for obtaining a license...

  18. 14 CFR 417.401 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Scope. 417.401 Section 417.401 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Ground Safety § 417.401 Scope. This subpart contains public...

  19. 14 CFR 415.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Scope. 415.1 Section 415.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.1 Scope. This part prescribes requirements for obtaining a license...

  20. 14 CFR 415.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Scope. 415.1 Section 415.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.1 Scope. This part prescribes requirements for obtaining a license...

  1. 14 CFR 414.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Scope. 414.1 Section 414.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING SAFETY APPROVALS General § 414.1 Scope. This part establishes procedures for obtaining a...

  2. 14 CFR 417.401 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Scope. 417.401 Section 417.401 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Ground Safety § 417.401 Scope. This subpart contains public...

  3. 14 CFR 414.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Scope. 414.1 Section 414.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING SAFETY APPROVALS General § 414.1 Scope. This part establishes procedures for obtaining a...

  4. 14 CFR 415.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Scope. 415.1 Section 415.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.1 Scope. This part prescribes requirements for obtaining a license...

  5. 14 CFR 417.401 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Scope. 417.401 Section 417.401 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Ground Safety § 417.401 Scope. This subpart contains public...

  6. 14 CFR 414.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Scope. 414.1 Section 414.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING SAFETY APPROVALS General § 414.1 Scope. This part establishes procedures for obtaining a...

  7. 14 CFR 414.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Scope. 414.1 Section 414.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING SAFETY APPROVALS General § 414.1 Scope. This part establishes procedures for obtaining a...

  8. 14 CFR 415.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Scope. 415.1 Section 415.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.1 Scope. This part prescribes requirements for obtaining a license...

  9. 14 CFR 417.401 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Scope. 417.401 Section 417.401 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Ground Safety § 417.401 Scope. This subpart contains public...

  10. 14 CFR 417.401 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Scope. 417.401 Section 417.401 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Ground Safety § 417.401 Scope. This subpart contains public...

  11. 49 CFR 79.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Scope. 79.1 Section 79.1 Transportation Office of the Secretary of Transportation MEDALS OF HONOR § 79.1 Scope. (a) This part implements 49 U.S.C. 80504, which authorizes the President of the United States to award a bronze medal for bravery to any...

  12. 49 CFR 79.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Scope. 79.1 Section 79.1 Transportation Office of the Secretary of Transportation MEDALS OF HONOR § 79.1 Scope. (a) This part implements 49 U.S.C. 80504, which authorizes the President of the United States to award a bronze medal for bravery to any...

  13. 49 CFR 79.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Scope. 79.1 Section 79.1 Transportation Office of the Secretary of Transportation MEDALS OF HONOR § 79.1 Scope. (a) This part implements 49 U.S.C. 80504, which authorizes the President of the United States to award a bronze medal for bravery to any...

  14. 49 CFR 79.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Scope. 79.1 Section 79.1 Transportation Office of the Secretary of Transportation MEDALS OF HONOR § 79.1 Scope. (a) This part implements 49 U.S.C. 80504, which authorizes the President of the United States to award a bronze medal for bravery to any...

  15. 49 CFR 79.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Scope. 79.1 Section 79.1 Transportation Office of the Secretary of Transportation MEDALS OF HONOR § 79.1 Scope. (a) This part implements 49 U.S.C. 80504, which authorizes the President of the United States to award a bronze medal for bravery to any...

  16. 30 CFR 880.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Scope. 880.1 Section 880.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION MINE FIRE CONTROL § 880.1 Scope. Projects for the control or extinguishment of outcrop or...

  17. 30 CFR 880.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Scope. 880.1 Section 880.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION MINE FIRE CONTROL § 880.1 Scope. Projects for the control or extinguishment of outcrop or...

  18. 32 CFR 752.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Scope. 752.1 Section 752.1 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY CLAIMS ADMIRALTY CLAIMS § 752.1 Scope. This part applies to admiralty-tort claims. These include claims against the United States for damage caused by a...

  19. 21 CFR 860.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Scope. 860.1 Section 860.1 Food and Drugs FOOD AND... CLASSIFICATION PROCEDURES General § 860.1 Scope. (a) This part implements sections 513, 514(b), 515(b), and 520(l) of the act with respect to the classification and reclassification of devices intended for human...

  20. 10 CFR 733.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope. 733.2 Section 733.2 Energy DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.2 Scope. This part applies to allegations of research misconduct with regard to scientific research conducted under a Department of Energy contract or an agreement. ...

  1. 10 CFR 733.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope. 733.2 Section 733.2 Energy DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.2 Scope. This part applies to allegations of research misconduct with regard to scientific research conducted under a Department of Energy contract or an agreement. ...

  2. 47 CFR 1.1601 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Scope. 1.1601 Section 1.1601 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Random Selection Procedures for Mass Media Services General Procedures § 1.1601 Scope. The provisions of this subpart, and the provisions...

  3. 47 CFR 1.1601 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Scope. 1.1601 Section 1.1601 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection Random Selection Procedures for Mass Media Services General Procedures § 1.1601 Scope. The provisions of this...

  4. 10 CFR 1703.101 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Scope. 1703.101 Section 1703.101 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PUBLIC INFORMATION AND REQUESTS § 1703.101 Scope. This part contains the Board's regulations implementing the Freedom of Information Act, 5 U.S.C. 552. ...

  5. 10 CFR 830.120 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Scope. 830.120 Section 830.120 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Quality Assurance Requirements § 830.120 Scope. This subpart establishes quality... affect, or may affect, nuclear safety of DOE nuclear facilities. ...

  6. 10 CFR 1703.101 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope. 1703.101 Section 1703.101 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PUBLIC INFORMATION AND REQUESTS § 1703.101 Scope. This part contains the Board's regulations implementing the Freedom of Information Act, 5 U.S.C. 552. ...

  7. 10 CFR 830.200 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope. 830.200 Section 830.200 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.200 Scope. This Subpart establishes safety basis requirements for hazard category 1, 2, and 3 DOE nuclear facilities. ...

  8. 10 CFR 830.120 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Scope. 830.120 Section 830.120 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Quality Assurance Requirements § 830.120 Scope. This subpart establishes quality... affect, or may affect, nuclear safety of DOE nuclear facilities. ...

  9. 10 CFR 1703.101 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope. 1703.101 Section 1703.101 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PUBLIC INFORMATION AND REQUESTS § 1703.101 Scope. This part contains the Board's regulations implementing the Freedom of Information Act, 5 U.S.C. 552. ...

  10. 10 CFR 830.120 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Scope. 830.120 Section 830.120 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Quality Assurance Requirements § 830.120 Scope. This subpart establishes quality... affect, or may affect, nuclear safety of DOE nuclear facilities. ...

  11. 10 CFR 830.200 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Scope. 830.200 Section 830.200 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.200 Scope. This Subpart establishes safety basis requirements for hazard category 1, 2, and 3 DOE nuclear facilities. ...

  12. 10 CFR 830.200 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Scope. 830.200 Section 830.200 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.200 Scope. This Subpart establishes safety basis requirements for hazard category 1, 2, and 3 DOE nuclear facilities. ...

  13. 10 CFR 830.200 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Scope. 830.200 Section 830.200 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.200 Scope. This Subpart establishes safety basis requirements for hazard category 1, 2, and 3 DOE nuclear facilities. ...

  14. 10 CFR 1703.101 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Scope. 1703.101 Section 1703.101 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PUBLIC INFORMATION AND REQUESTS § 1703.101 Scope. This part contains the Board's regulations implementing the Freedom of Information Act, 5 U.S.C. 552. ...

  15. 10 CFR 1703.101 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Scope. 1703.101 Section 1703.101 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PUBLIC INFORMATION AND REQUESTS § 1703.101 Scope. This part contains the Board's regulations implementing the Freedom of Information Act, 5 U.S.C. 552. ...

  16. 10 CFR 1705.01 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Scope. 1705.01 Section 1705.01 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.01 Scope. This part contains the Board's regulations implementing the Privacy Act of 1974, Public Law 93-579, 5 U.S.C. 552a. ...

  17. 10 CFR 830.120 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope. 830.120 Section 830.120 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Quality Assurance Requirements § 830.120 Scope. This subpart establishes quality... affect, or may affect, nuclear safety of DOE nuclear facilities. ...

  18. 21 CFR 530.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Scope. 530.1 Section 530.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS EXTRALABEL DRUG USE IN ANIMALS General Provisions § 530.1 Scope. This part applies to the...

  19. 49 CFR 665.3 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Scope. 665.3 Section 665.3 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING General § 665.3 Scope. This part shall apply to an entity receiving Federal...

  20. 49 CFR 665.3 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Scope. 665.3 Section 665.3 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING General § 665.3 Scope. This part shall apply to an entity receiving Federal...

  1. 49 CFR 605.2 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Scope. 605.2 Section 605.2 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION SCHOOL BUS OPERATIONS General § 605.2 Scope. These regulations apply to all recipients...

  2. 49 CFR 665.3 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Scope. 665.3 Section 665.3 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING General § 665.3 Scope. This part shall apply to an entity receiving Federal...

  3. 49 CFR 605.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Scope. 605.2 Section 605.2 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION SCHOOL BUS OPERATIONS General § 605.2 Scope. These regulations apply to all recipients...

  4. 49 CFR 605.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Scope. 605.2 Section 605.2 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION SCHOOL BUS OPERATIONS General § 605.2 Scope. These regulations apply to all recipients...

  5. 49 CFR 605.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Scope. 605.2 Section 605.2 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION SCHOOL BUS OPERATIONS General § 605.2 Scope. These regulations apply to all recipients...

  6. 49 CFR 665.3 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Scope. 665.3 Section 665.3 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING General § 665.3 Scope. This part shall apply to an entity receiving Federal...

  7. 49 CFR 605.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Scope. 605.2 Section 605.2 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION SCHOOL BUS OPERATIONS General § 605.2 Scope. These regulations apply to all recipients...

  8. 49 CFR 665.3 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Scope. 665.3 Section 665.3 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING General § 665.3 Scope. This part shall apply to an entity receiving Federal...

  9. 30 CFR 879.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Scope. 879.1 Section 879.1 Mineral Resources... RECLAMATION ACQUISITION, MANAGEMENT, AND DISPOSITION OF LANDS AND WATER § 879.1 Scope. This part establishes procedures for acquisition of eligible land and water resources for emergency abatement activities...

  10. 14 CFR 1245.100 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Scope. 1245.100 Section 1245.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.100 Scope. This subpart prescribes regulations for the waiver...

  11. 14 CFR 1245.100 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Scope. 1245.100 Section 1245.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.100 Scope. This subpart prescribes regulations for the waiver of...

  12. 30 CFR 880.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Scope. 880.1 Section 880.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION MINE FIRE CONTROL § 880.1 Scope. Projects for the control or extinguishment of outcrop or...

  13. 30 CFR 870.1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Scope. 870.1 Section 870.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION ABANDONED MINE RECLAMATION FUND-FEE COLLECTION AND COAL PRODUCTION REPORTING § 870.1 Scope. This...

  14. 30 CFR 870.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Scope. 870.1 Section 870.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION ABANDONED MINE RECLAMATION FUND-FEE COLLECTION AND COAL PRODUCTION REPORTING § 870.1 Scope. This...

  15. 30 CFR 870.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Scope. 870.1 Section 870.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION ABANDONED MINE RECLAMATION FUND-FEE COLLECTION AND COAL PRODUCTION REPORTING § 870.1 Scope. This...

  16. 30 CFR 870.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Scope. 870.1 Section 870.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION ABANDONED MINE RECLAMATION FUND-FEE COLLECTION AND COAL PRODUCTION REPORTING § 870.1 Scope. This...

  17. 30 CFR 880.1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Scope. 880.1 Section 880.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION MINE FIRE CONTROL § 880.1 Scope. Projects for the control or extinguishment of outcrop or...

  18. 30 CFR 870.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Scope. 870.1 Section 870.1 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION ABANDONED MINE RECLAMATION FUND-FEE COLLECTION AND COAL PRODUCTION REPORTING § 870.1 Scope. This...

  19. 46 CFR 272.11 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Scope. 272.11 Section 272.11 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS AFFECTING SUBSIDIZED VESSELS AND OPERATORS REQUIREMENTS... Requirements and Procedures for Determining the Condition of Eligible Vessels § 272.11 Scope. This...

  20. 10 CFR 435.301 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Scope. 435.301 Section 435.301 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS FOR NEW FEDERAL LOW-RISE RESIDENTIAL BUILDINGS Mandatory Energy Efficiency Standards for Federal Residential Buildings § 435.301 Scope. (a) The energy...

  1. 10 CFR 435.301 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Scope. 435.301 Section 435.301 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS FOR NEW FEDERAL LOW-RISE RESIDENTIAL BUILDINGS Mandatory Energy Efficiency Standards for Federal Residential Buildings § 435.301 Scope. (a) The energy...

  2. 10 CFR 435.301 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Scope. 435.301 Section 435.301 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS FOR NEW FEDERAL LOW-RISE RESIDENTIAL BUILDINGS Mandatory Energy Efficiency Standards for Federal Residential Buildings § 435.301 Scope. (a) The energy...

  3. 10 CFR 435.301 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Scope. 435.301 Section 435.301 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS FOR NEW FEDERAL LOW-RISE RESIDENTIAL BUILDINGS Mandatory Energy Efficiency Standards for Federal Residential Buildings § 435.301 Scope. (a) The energy...

  4. 10 CFR 435.301 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Scope. 435.301 Section 435.301 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS FOR NEW FEDERAL LOW-RISE RESIDENTIAL BUILDINGS Mandatory Energy Efficiency Standards for Federal Residential Buildings § 435.301 Scope. (a) The energy...

  5. 6 CFR 7.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope..., National Industrial Security Program, and its implementing directives. (c) This part is independent of...

  6. 6 CFR 7.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope..., National Industrial Security Program, and its implementing directives. (c) This part is independent of...

  7. 75 FR 79339 - Notice of Scope Rulings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... the scope of the antidumping duty order; May 12, 2010. Germany A-428-801: Ball Bearings and Parts... June 30, 2010: Germany A-428-801: Ball Bearings and Parts From Germany Requestor: Myonic GmbH; whether... its flower candles are within the scope of the antidumping duty order; requested June 24, 2009. A-570...

  8. 32 CFR 173.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CERTIFICATE AND PROFIT REDUCTION CLAUSE § 173.1 Scope. (a) The purpose of the Competitive Information... Profit Reduction Clause is to ensure effective protection of the Government's interest in making contract... 32 National Defense 1 2011-07-01 2011-07-01 false Scope. 173.1 Section 173.1 National...

  9. 32 CFR 173.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CERTIFICATE AND PROFIT REDUCTION CLAUSE § 173.1 Scope. (a) The purpose of the Competitive Information... Profit Reduction Clause is to ensure effective protection of the Government's interest in making contract... 32 National Defense 1 2010-07-01 2010-07-01 false Scope. 173.1 Section 173.1 National...

  10. 10 CFR 26.3 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Scope. 26.3 Section 26.3 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.3 Scope. (a) Licensees who are authorized to operate a nuclear power reactor under 10 CFR 50.57, and holders of a combined license under 10 CFR...

  11. 10 CFR 26.3 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Scope. 26.3 Section 26.3 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Administrative Provisions § 26.3 Scope. (a) Licensees who are authorized to operate a nuclear power reactor under 10 CFR 50.57, and holders of a combined license under 10 CFR...

  12. 21 CFR 601.90 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Scope. 601.90 Section 601.90 Food and Drugs FOOD... Approval of Biological Products When Human Efficacy Studies Are Not Ethical or Feasible § 601.90 Scope... permanently disabling toxic biological, chemical, radiological, or nuclear substance; and field trials to...

  13. 45 CFR 1210.1-2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Scope. 1210.1-2 Section 1210.1-2 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VISTA TRAINEE DESELECTION AND VOLUNTEER EARLY TERMINATION PROCEDURES General § 1210.1-2 Scope. (a) This part applies to all Trainees and...

  14. 45 CFR 12.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Scope. 12.2 Section 12.2 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION DISPOSAL AND UTILIZATION OF SURPLUS REAL PROPERTY FOR PUBLIC HEALTH PURPOSES § 12.2 Scope. This part is applicable to surplus real property located within any State which is appropriate...

  15. 21 CFR 1314.01 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Scope. 1314.01 Section 1314.01 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE RETAIL SALE OF SCHEDULED LISTED CHEMICAL PRODUCTS General § 1314.01 Scope. This part specifies the requirements for retail sales of scheduled listed chemical...

  16. 21 CFR 1314.01 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Scope. 1314.01 Section 1314.01 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE RETAIL SALE OF SCHEDULED LISTED CHEMICAL PRODUCTS General § 1314.01 Scope. This part specifies the requirements for retail sales of scheduled listed chemical...

  17. 21 CFR 1314.01 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Scope. 1314.01 Section 1314.01 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE RETAIL SALE OF SCHEDULED LISTED CHEMICAL PRODUCTS General § 1314.01 Scope. This part specifies the requirements for retail sales of scheduled listed chemical...

  18. 30 CFR 48.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Scope. 48.1 Section 48.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING TRAINING AND RETRAINING OF MINERS Training and Retraining of Underground Miners § 48.1 Scope. The provisions of this subpart A...

  19. 30 CFR 48.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Scope. 48.1 Section 48.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING TRAINING AND RETRAINING OF MINERS Training and Retraining of Underground Miners § 48.1 Scope. The provisions of this subpart A...

  20. 30 CFR 48.1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Scope. 48.1 Section 48.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING TRAINING AND RETRAINING OF MINERS Training and Retraining of Underground Miners § 48.1 Scope. The provisions of this subpart A...

  1. Special Education in Indonesia (Scope and Development).

    ERIC Educational Resources Information Center

    Semiawan, Conny

    The paper covers characteristics of Indonesia's special education program. Considered are the scope of special education, some viewpoints on the impact of culture on the perspective of special education in Indonesia (including programs, services, teacher training, and financial resources). The scope of special education is considered; and some…

  2. 47 CFR 212.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Scope. 212.2 Section 212.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL PROCEDURES FOR OBTAINING INTERNATIONAL TELECOMMUNICATION SERVICE FOR USE DURING A WARTIME EMERGENCY § 212.2 Scope. The procedures in...

  3. 47 CFR 213.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Scope. 213.2 Section 213.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL GOVERNMENT AND PUBLIC CORRESPONDENCE TELECOMMUNICATIONS PRECEDENCE SYSTEM § 213.2 Scope. The precedence system contained herein...

  4. 47 CFR 213.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Scope. 213.2 Section 213.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL GOVERNMENT AND PUBLIC CORRESPONDENCE TELECOMMUNICATIONS PRECEDENCE SYSTEM § 213.2 Scope. The precedence system contained herein...

  5. 47 CFR 213.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Scope. 213.2 Section 213.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL GOVERNMENT AND PUBLIC CORRESPONDENCE TELECOMMUNICATIONS PRECEDENCE SYSTEM § 213.2 Scope. The precedence system contained herein...

  6. 47 CFR 212.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Scope. 212.2 Section 212.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL PROCEDURES FOR OBTAINING INTERNATIONAL TELECOMMUNICATION SERVICE FOR USE DURING A WARTIME EMERGENCY § 212.2 Scope. The procedures in...

  7. 47 CFR 213.2 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Scope. 213.2 Section 213.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL GOVERNMENT AND PUBLIC CORRESPONDENCE TELECOMMUNICATIONS PRECEDENCE SYSTEM § 213.2 Scope. The precedence system contained herein...

  8. 47 CFR 213.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Scope. 213.2 Section 213.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL GOVERNMENT AND PUBLIC CORRESPONDENCE TELECOMMUNICATIONS PRECEDENCE SYSTEM § 213.2 Scope. The precedence system contained herein...

  9. 47 CFR 212.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Scope. 212.2 Section 212.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL PROCEDURES FOR OBTAINING INTERNATIONAL TELECOMMUNICATION SERVICE FOR USE DURING A WARTIME EMERGENCY § 212.2 Scope. The procedures in...

  10. 47 CFR 212.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Scope. 212.2 Section 212.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL PROCEDURES FOR OBTAINING INTERNATIONAL TELECOMMUNICATION SERVICE FOR USE DURING A WARTIME EMERGENCY § 212.2 Scope. The procedures in...

  11. 14 CFR 1221.100 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Scope. 1221.100 Section 1221.100... CONGRESSIONAL SPACE MEDAL OF HONOR NASA Seal, NASA Insignia, NASA Logotype, NASA Program Identifiers, NASA Flags..., and the NASA Flags. This subpart also establishes and sets forth the concept and scope of the NASA...

  12. 48 CFR 2942.1501 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Scope. 2942.1501 Section 2942.1501 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Contractor Performance Information 2942.1501 Scope. This subpart provides...

  13. Special Education in Indonesia (Scope and Development).

    ERIC Educational Resources Information Center

    Semiawan, Conny

    The paper covers characteristics of Indonesia's special education program. Considered are the scope of special education, some viewpoints on the impact of culture on the perspective of special education in Indonesia (including programs, services, teacher training, and financial resources). The scope of special education is considered; and some…

  14. 21 CFR 1311.01 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Scope. 1311.01 Section 1311.01 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS General § 1311.01 Scope. This part sets forth the rules governing the creation, transmission, and storage of...

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    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Scope. 1311.01 Section 1311.01 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS General § 1311.01 Scope. This part sets forth the rules governing the creation, transmission, and storage of...

  16. 10 CFR 766.100 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Scope. 766.100 Section 766.100 Energy DEPARTMENT OF ENERGY URANIUM ENRICHMENT DECONTAMINATION AND DECOMMISSIONING FUND; PROCEDURES FOR SPECIAL ASSESSMENT OF DOMESTIC UTILITIES Procedures for Special Assessment § 766.100 Scope. This subpart sets forth the procedures for the...

  17. 10 CFR 766.100 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Scope. 766.100 Section 766.100 Energy DEPARTMENT OF ENERGY URANIUM ENRICHMENT DECONTAMINATION AND DECOMMISSIONING FUND; PROCEDURES FOR SPECIAL ASSESSMENT OF DOMESTIC UTILITIES Procedures for Special Assessment § 766.100 Scope. This subpart sets forth the procedures for the...

  18. 10 CFR 766.100 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Scope. 766.100 Section 766.100 Energy DEPARTMENT OF ENERGY URANIUM ENRICHMENT DECONTAMINATION AND DECOMMISSIONING FUND; PROCEDURES FOR SPECIAL ASSESSMENT OF DOMESTIC UTILITIES Procedures for Special Assessment § 766.100 Scope. This subpart sets forth the procedures for the...

  19. 10 CFR 766.100 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Scope. 766.100 Section 766.100 Energy DEPARTMENT OF ENERGY URANIUM ENRICHMENT DECONTAMINATION AND DECOMMISSIONING FUND; PROCEDURES FOR SPECIAL ASSESSMENT OF DOMESTIC UTILITIES Procedures for Special Assessment § 766.100 Scope. This subpart sets forth the procedures for the...

  20. 10 CFR 766.100 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Scope. 766.100 Section 766.100 Energy DEPARTMENT OF ENERGY URANIUM ENRICHMENT DECONTAMINATION AND DECOMMISSIONING FUND; PROCEDURES FOR SPECIAL ASSESSMENT OF DOMESTIC UTILITIES Procedures for Special Assessment § 766.100 Scope. This subpart sets forth the procedures for the...