Science.gov

Sample records for 4-t treaty alien

  1. 32 CFR 1630.46 - Class 4-T: Treaty alien.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Class 4-T: Treaty alien. 1630.46 Section 1630.46 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM CLASSIFICATION RULES § 1630.46 Class 4-T: Treaty alien. In Class 4-T shall be placed any registrant who is an alien...

  2. 32 CFR 1630.46 - Class 4-T: Treaty alien.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Class 4-T: Treaty alien. 1630.46 Section 1630.46 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM CLASSIFICATION RULES § 1630.46 Class 4-T: Treaty alien. In Class 4-T shall be placed any registrant who is an alien...

  3. 32 CFR 1630.46 - Class 4-T: Treaty alien.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Class 4-T: Treaty alien. 1630.46 Section 1630.46 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM CLASSIFICATION RULES § 1630.46 Class 4-T: Treaty alien. In Class 4-T shall be placed any registrant who is an alien...

  4. 32 CFR 1630.46 - Class 4-T: Treaty alien.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Class 4-T: Treaty alien. 1630.46 Section 1630.46 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM CLASSIFICATION RULES § 1630.46 Class 4-T: Treaty alien. In Class 4-T shall be placed any registrant who is an alien...

  5. 32 CFR 1630.46 - Class 4-T: Treaty alien.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Class 4-T: Treaty alien. 1630.46 Section 1630.46 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM CLASSIFICATION RULES § 1630.46 Class 4-T: Treaty alien. In Class 4-T shall be placed any registrant who is an alien...

  6. 22 CFR 41.51 - Treaty trader, treaty investor, or treaty alien in a specialty occupation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... international exchange of items of trade for consideration between the United States and the treaty country... immediate exchange of items of trade. This exchange must be traceable and identifiable. Title to the trade...) Presents to a consular officer evidence of the alien's academic or other qualifying credentials as...

  7. 22 CFR 41.51 - Treaty trader, treaty investor, or treaty alien in a specialty occupation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... established in connection with continuous activities in such areas as product improvement, quality control, or... to ensure a continuous flow of trade items between the United States and the treaty country. This continuous flow contemplates numerous exchanges over time rather than a single transaction, regardless of...

  8. 22 CFR 41.1 - Exemption by law or treaty from passport and visa requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Exemption by law or treaty from passport and... Required for Certain Nonimmigrants § 41.1 Exemption by law or treaty from passport and visa requirements... Atlantic Treaty (TIAS 2978; 5 U.S.T. 875.) (f) Aliens entering pursuant to International Boundary and...

  9. 22 CFR 41.1 - Exemption by law or treaty from passport and visa requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Exemption by law or treaty from passport and... Required for Certain Nonimmigrants § 41.1 Exemption by law or treaty from passport and visa requirements... Atlantic Treaty (TIAS 2978; 5 U.S.T. 875.) (f) Aliens entering pursuant to International Boundary and...

  10. 22 CFR 41.1 - Exemption by law or treaty from passport and visa requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exemption by law or treaty from passport and... Required for Certain Nonimmigrants § 41.1 Exemption by law or treaty from passport and visa requirements... Atlantic Treaty (TIAS 2978; 5 U.S.T. 875.) (f) Aliens entering pursuant to International Boundary and...

  11. 22 CFR 41.1 - Exemption by law or treaty from passport and visa requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Exemption by law or treaty from passport and... Required for Certain Nonimmigrants § 41.1 Exemption by law or treaty from passport and visa requirements... Atlantic Treaty (TIAS 2978; 5 U.S.T. 875.) (f) Aliens entering pursuant to International Boundary and...

  12. 22 CFR 41.1 - Exemption by law or treaty from passport and visa requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Exemption by law or treaty from passport and... Required for Certain Nonimmigrants § 41.1 Exemption by law or treaty from passport and visa requirements... Atlantic Treaty (TIAS 2978; 5 U.S.T. 875.) (f) Aliens entering pursuant to International Boundary and...

  13. 26 CFR 1.871-12 - Determination of tax on treaty income.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 9 2013-04-01 2013-04-01 false Determination of tax on treaty income. 1.871-12 Section 1.871-12 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Nonresident Aliens and Foreign Corporations § 1.871-12 Determination of tax on treaty income. (a)...

  14. 22 CFR 41.51 - Treaty trader, treaty investor, or treaty alien in a specialty occupation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., greater weight is given to more numerous exchanges of larger value. In the case of smaller businesses, an... provisions of INA 101(a)(15)(E). (4) Representative of foreign information media. Representatives of foreign information media shall first be considered for possible classification as nonimmigrants under the...

  15. 22 CFR 41.51 - Treaty trader, treaty investor, or treaty alien in a specialty occupation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., greater weight is given to more numerous exchanges of larger value. In the case of smaller businesses, an... provisions of INA 101(a)(15)(E). (4) Representative of foreign information media. Representatives of foreign information media shall first be considered for possible classification as nonimmigrants under the...

  16. 22 CFR 41.51 - Treaty trader, treaty investor, or treaty alien in a specialty occupation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., greater weight is given to more numerous exchanges of larger value. In the case of smaller businesses, an... provisions of INA 101(a)(15)(E). (4) Representative of foreign information media. Representatives of foreign information media shall first be considered for possible classification as nonimmigrants under the...

  17. Alienation Incident.

    ERIC Educational Resources Information Center

    Wasserman, Louis

    1979-01-01

    Critiques Marxian "cures" for alienation as discussed in Karl Marx's "Economic and Philosophical Manuscripts." Also traces the activity of a former student who joined the revolution in Cuba. Journal available from 7 Harwood Drive, Amherst, New York, 14226. (KC)

  18. Alien Abductions

    NASA Astrophysics Data System (ADS)

    Nickell, Joe

    2000-03-01

    Since the beginning of the modern UFO craze in 1947, an elaborate mythology has developed concerning alleged extraterrestrial visitations. ``Flying saucer" sightings (typically involving misperceptions of such mundane phenomena as meteors and research balloons) began to be accompanied in the 1950s by reports from ``contactees," persons who claimed to have had close encounters with, even to have been transported to distant planets by, UFO occupants. By the 1960s came reports of sporadic ``abductions" which have proliferated in correlation with media interest. (Indeed, by interaction between claimants and media the portrayal of aliens has evolved from a multiplicity of types into the rather standardized big-eyed humanoid model.) While evidence of alien contact has often been faked--as by spurious photos, ``crop circles," and the notorious ``Alien Autopsy" film--few alien abduction reports appear to be hoaxes. Most seem instead to come from sincere, sane individuals. Nevertheless, not one has been authenticated, and serious investigation shows that such claims can be explained as sleep-related phenomena (notably ``waking dreams"), hypnotic confabulation, and other psychological factors. As is typical of other mythologies, the alien myth involves supernormal beings that may interact with humans, and it purports to explain the workings of the universe and humanity's place within it.

  19. 8 CFR 319.5 - Public international organizations in which the U.S. participates by treaty or statute.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Public international organizations in which the U.S. participates by treaty or statute. 319.5 Section 319.5 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS SPECIAL CLASSES OF PERSONS WHO MAY BE NATURALIZED: SPOUSES...

  20. 8 CFR 319.5 - Public international organizations in which the U.S. participates by treaty or statute.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Public international organizations in which the U.S. participates by treaty or statute. 319.5 Section 319.5 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS SPECIAL CLASSES OF PERSONS WHO MAY BE NATURALIZED: SPOUSES...

  1. 26 CFR 1.1441-6 - Claim of reduced withholding under an income tax treaty.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 12 2012-04-01 2012-04-01 false Claim of reduced withholding under an income tax treaty. 1.1441-6 Section 1.1441-6 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Withholding of Tax on Nonresident Aliens and Foreign Corporations and...

  2. The ABM Treaty

    SciTech Connect

    Stutzle, W.; Jasani, B.; Cowen, R.

    1987-01-01

    The foremost challenge of this age and the next is to harness our political resources to prevent the East-West relationship from turning into a conflict. Among the measures employed to stabilize the strategic relationship, the 1972 Anti-Ballistic Missile (ABM) Treaty is of profound importance. It codifies the central principle of the nuclear age: a co-operative approach in limiting offensive and defensive strategic forces. This principle has been challenged-both by failures in East and West to resist the allure of technology and by a more general errosion of political will to tackle together the problems of the nuclear offence-defence relationship. This paper makes a contribution to the debate over the strategic relationship, in particular the role of the ABM Treaty. It is first in a series of Strategic Issue Papers (SIP) that address topical issues of international peace and security. In order to contribute to a better understanding of the problems involved and to stimulate debate, SIPRI has produced this book before the commencement of the third ABM Treaty Review Conference.

  3. Alienation, Dogmatism and Acquiescence.

    ERIC Educational Resources Information Center

    Ray, John J.

    1984-01-01

    Examined the issue of acquiescence by administering a balanced dogmatism scale and a balanced alienation scale to a random sample of Australians (N=118). Results showed that dogmatism and alienation did not correlate when acquiescence was controlled. (LLL)

  4. The coregulator Alien

    PubMed Central

    Papaioannou, Maria; Melle, Christian; Baniahmad, Aria

    2007-01-01

    Alien has characteristics of a corepressor for selected members of the nuclear hormone receptor (NHR) superfamily and also for transcription factors involved in cell cycle regulation and DNA repair. Alien mediates gene silencing and represses the transactivation of specific NHRs and other transcription factors to modulate hormone response and cell proliferation. Alien is a highly conserved protein and is expressed in a wide variety of tissues. Knockout of the gene encoding Alien in mice is embryonic lethal at a very early stage, indicating an important evolutionary role in multicellular organisms. From a mechanistic perspective, the corepressor function of Alien is in part mediated by histone deacetylase (HDAC) activity. In addition, Alien seems to modulate nucleosome assembly activity. This suggests that Alien is acting on chromatin not only through recruitment of histone-modifying activities, but also through enhancing nucleosome assembly. PMID:18174916

  5. Shooting down the ABM Treaty

    SciTech Connect

    Mendelsohn, J.; Rhinelander, J.B.

    1994-09-01

    The Clinton administration is on a path to undermine the Anti-Ballistic Missile (ABM) Treaty by proposing {open_quotes}clarifications{close_quotes} to the treaty that would permit the deployment of an extensive, highly capable anti-theater ballistic missile (ATBM) defense system.

  6. Alienation and Illness.

    ERIC Educational Resources Information Center

    Kobasa, Suzanne C.

    Reviews of studies of four groups (business executives, lawyers, Army officers, and working women) which demonstrate the health-damaging effects of alienation in certain life situations show that, when under stress, members of these groups who feel alienated fall ill, medically and/or psychiatrically. Three models are described which may explain…

  7. The aliens are hiding

    NASA Astrophysics Data System (ADS)

    2015-06-01

    In reply to the physicsworld.com news story “Trail goes cold on alien hotspots, for now” (28 April, http://ow.ly/MeOpZ; see also p5), which described the results of a survey that looked for unexplained pockets of infrared radiation that could have been produced by advanced alien civilizations.

  8. Alienation from School

    ERIC Educational Resources Information Center

    Hascher, Tina; Hagenauer, Gerda

    2010-01-01

    Two studies aimed at understanding the time course of alienation from school and school factors that may influence alienation from school during early adolescence. In Study 1, 434 students from grade 5-8 participated (cross-sectional design). In Study 2, we followed 356 students from grade 6-7 (longitudinal design). The results confirm the…

  9. Alienation Attitudes and Exploratory Behavior.

    ERIC Educational Resources Information Center

    Maddi, Salvatore R.

    In order to give the psychological conception of alienation greater cogency relative to the influence of sociological alienation, research is needed that ties alienation attitudes to individual personal behavior. It was hypothesized that the stronger the alienation attitudes of people, the weaker will be their exploratory behavior. Thus,…

  10. Memory CD4 T cells in influenza.

    PubMed

    Zens, Kyra D; Farber, Donna L

    2015-01-01

    Influenza A virus is a significant cause of morbidity and mortality worldwide, particularly among young children and the elderly. Current vaccines induce neutralizing antibody responses directed toward highly variable viral surface proteins, resulting in limited heterosubtypic protection to new viral serotypes. By contrast, memory CD4 T cells recognize conserved viral proteins and are cross-reactive to multiple influenza strains. In humans, virus-specific memory CD4 T cells were found to be the protective correlate in human influenza challenge studies, suggesting their key role in protective immunity. In mouse models, memory CD4 T cells can mediate protective responses to secondary influenza infection independent of B cells or CD8 T cells, and can influence innate immune responses. Importantly, a newly defined, tissue-resident CD4 memory population has been demonstrated to be retained in lung tissue and promote optimal protective responses to an influenza infection. Here, we review the current state of results regarding the generation of memory CD4 T cells following primary influenza infection, mechanisms for their enhanced efficacy in protection from secondary challenge including their phenotype, localization, and function in the context of both mouse models and human infection. We also discuss the generation of memory CD4 T cells in response to influenza vaccines and its future implications for vaccinology. PMID:25005927

  11. Life under alien skies

    NASA Astrophysics Data System (ADS)

    Dartnell, Lewis

    2012-04-01

    As the number of confirmed extrasolar planets increases, so does the likelihood that some of them will harbour life. Lewis Dartnell describes some preliminary - but increasingly well founded - efforts to predict what alien plants and animals might look like.

  12. The North Atlantic Treaty Organization at 40.

    ERIC Educational Resources Information Center

    Baker, John A.

    1989-01-01

    Surveys the history of the North Atlantic Treaty Organization's (NATO) on the 40th anniversary of the signing of the Treaty. Highlights milestones in the Organization's history of dealing with the Soviet Union, from containment to the Intermediate-Range Nuclear Forces Treaty. Discusses needs, tasks, and challenges that NATO faces in the 1990s.…

  13. Questions and Answers on Treaty Rights.

    ERIC Educational Resources Information Center

    National Coalition to Support Indian Treaties, Seattle, WA.

    Treaties have been upheld in the U.S. Constitution as "the supreme law of the land". U.S. courts have repeatedly recognized Indian nations as sovereign and, consequently, treaties between Indian nations and the United States have the dignity as well as the full force and effect of any other international agreement. While many treaties over the…

  14. 8 CFR 211.5 - Alien commuters.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Alien commuters. 211.5 Section 211.5 Aliens...: IMMIGRANTS; WAIVERS § 211.5 Alien commuters. (a) General. An alien lawfully admitted for permanent residence.... An alien commuter engaged in seasonal work will be presumed to have taken up residence in the...

  15. 8 CFR 211.5 - Alien commuters.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Alien commuters. 211.5 Section 211.5 Aliens...: IMMIGRANTS; WAIVERS § 211.5 Alien commuters. (a) General. An alien lawfully admitted for permanent residence.... An alien commuter engaged in seasonal work will be presumed to have taken up residence in the...

  16. A Study of Resident Fee Status for Certain Nonimmigrant Aliens. A Report in Response to Senate Resolution 1975-144.

    ERIC Educational Resources Information Center

    Washington State Council for Postsecondary Education, Olympia.

    In recent years there have been a number of proposals to extend resident tuition and fee status to certain groups of foreign nationals (E-1) in the State of Washington. An E-1 national is "any nonimmigrant alien entitled to enter the United States under and in pursuance of the provisions of a treaty of commerce and navigation between the United…

  17. Alien Life Imagined

    NASA Astrophysics Data System (ADS)

    Brake, Mark

    2012-11-01

    1. Kosmos: aliens in ancient Greece; 2. The world turned upside down: Copernicanism and the voyages of discovery; 3. In Newton's train: pluralism and the system of the world; 4. Extraterrestrials in the early machine age; 5. After Darwin: the war of the worlds; 6. Einstein's sky: life in the new universe; 7. Ever since SETI: astrobiology in the space age; References; Index.

  18. Aliens and atheism

    NASA Astrophysics Data System (ADS)

    Campos, Sergio; de Muynck, Willem; Virginia; Peerally, Abed; Tyler, David; Stephen

    2014-11-01

    In reply to the physicsworld.com blog post "Aliens and atheists" (2 October, http://ow.ly/CQzu4), about a survey that found that atheists are more likely than religious people to believe that life exists on other planets.

  19. Alien invasive birds.

    PubMed

    Brochier, B; Vangeluwe, D; van den Berg, T

    2010-08-01

    A bird species is regarded as alien invasive if it has been introduced, intentionally or accidentally, to a location where it did not previously occur naturally, becomes capable of establishing a breeding population without further intervention by humans, spreads and becomes a pest affecting the environment, the local biodiversity, the economy and/or society, including human health. European Starling (Sturnus vulgaris), Common Myna (Acridotheres tristis) and Red-vented Bulbul (Pycnonotus cafer) have been included on the list of '100 of the World's Worst Invasive Alien Species', a subset of the Global Invasive Species Database. The 'Delivering Alien Invasive Species Inventories for Europe' project has selected Canada Goose (Branta canadensis), Ruddy Duck (Oxyura jamaicensis), Rose-ringed Parakeet (Psittacula krameri) and Sacred Ibis (Threskiornis aethiopicus) as among 100 of the worst invasive species in Europe. For each of these alien bird species, the geographic range (native and introduced range), the introduction pathway, the general impacts and the management methods are presented. PMID:20919578

  20. Forgetting and remembering alienation theory.

    PubMed

    Yuill, Chris

    2011-01-01

    Alienation theory has acted as the stimulus for a great deal of research and writing in the history of sociology. It has formed the basis of many sociological "classics" focused on the workplace and the experiences of workers, and has also been mobilized to chart wider social malaise and individual troubles. Alienation theory usage has, however, declined significantly since its heyday of the 1960s and 1970s. Here, the reasons why alienation theory was "forgotten" and what can be gained by "remembering" alienation theory are explored. to realize this ambition this article proceeds by (1) briefly visiting differing definitions of alienation theory, before charting its high point, and the various debates and tensions of the time, during the 1960s and 1970s; (2) analysing the reasons why alienation theory fell from grace from the 1980s onwards; (3) elaborating how and why alienation theory is still relevant for sociology and the wider social sciences today. PMID:21809508

  1. 22 CFR 41.71 - Transit aliens.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Transit aliens. 41.71 Section 41.71 Foreign... NATIONALITY ACT, AS AMENDED Transit Aliens § 41.71 Transit aliens. (a) Transit aliens—general. An alien is classifiable as a nonimmigrant transit alien under INA 101(a) (15) (C) if the consular officer is...

  2. 8 CFR 211.5 - Alien commuters.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... shall be made in accordance with 8 CFR 264.5. ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Alien commuters. 211.5 Section 211.5 Aliens...: IMMIGRANTS; WAIVERS § 211.5 Alien commuters. (a) General. An alien lawfully admitted for permanent...

  3. 22 CFR 41.71 - Transit aliens.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Transit aliens. 41.71 Section 41.71 Foreign... NATIONALITY ACT, AS AMENDED Transit Aliens § 41.71 Transit aliens. (a) Transit aliens—general. An alien is classifiable as a nonimmigrant transit alien under INA 101(a) (15) (C) if the consular officer is...

  4. 8 CFR 232.3 - Arriving aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Arriving aliens. 232.3 Section 232.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS DETENTION OF ALIENS FOR PHYSICAL AND MENTAL EXAMINATION § 232.3 Arriving aliens. When a district director has reasonable...

  5. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for...

  6. 8 CFR 236.13 - Ineligible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 236.13 Section 236.13 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED Family Unity Program §...

  7. 22 CFR 41.71 - Transit aliens.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Transit aliens. 41.71 Section 41.71 Foreign... NATIONALITY ACT, AS AMENDED Transit Aliens § 41.71 Transit aliens. (a) Transit aliens—general. An alien is classifiable as a nonimmigrant transit alien under INA 101(a) (15) (C) if the consular officer is...

  8. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for...

  9. 8 CFR 211.5 - Alien commuters.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... shall be made in accordance with 8 CFR 264.5. ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Alien commuters. 211.5 Section 211.5 Aliens...: IMMIGRANTS; WAIVERS § 211.5 Alien commuters. (a) General. An alien lawfully admitted for permanent...

  10. 8 CFR 236.13 - Ineligible aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Ineligible aliens. 236.13 Section 236.13 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED Family Unity Program §...

  11. 8 CFR 232.3 - Arriving aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Arriving aliens. 232.3 Section 232.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS DETENTION OF ALIENS FOR PHYSICAL AND MENTAL EXAMINATION § 232.3 Arriving aliens. When a district director has reasonable...

  12. 8 CFR 232.3 - Arriving aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Arriving aliens. 232.3 Section 232.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS DETENTION OF ALIENS FOR PHYSICAL AND MENTAL EXAMINATION § 232.3 Arriving aliens. When a district director has reasonable...

  13. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for...

  14. 8 CFR 236.13 - Ineligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Ineligible aliens. 236.13 Section 236.13 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED Family Unity Program §...

  15. 22 CFR 41.71 - Transit aliens.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Transit aliens. 41.71 Section 41.71 Foreign... NATIONALITY ACT, AS AMENDED Transit Aliens § 41.71 Transit aliens. (a) Transit aliens—general. An alien is classifiable as a nonimmigrant transit alien under INA 101(a) (15) (C) if the consular officer is...

  16. 8 CFR 236.13 - Ineligible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Ineligible aliens. 236.13 Section 236.13 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED Family Unity Program §...

  17. 8 CFR 232.3 - Arriving aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Arriving aliens. 232.3 Section 232.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS DETENTION OF ALIENS FOR PHYSICAL AND MENTAL EXAMINATION § 232.3 Arriving aliens. When a district director has reasonable...

  18. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for...

  19. 8 CFR 232.3 - Arriving aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Arriving aliens. 232.3 Section 232.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS DETENTION OF ALIENS FOR PHYSICAL AND MENTAL EXAMINATION § 232.3 Arriving aliens. When a district director has reasonable...

  20. 22 CFR 41.71 - Transit aliens.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Transit aliens. 41.71 Section 41.71 Foreign... NATIONALITY ACT, AS AMENDED Transit Aliens § 41.71 Transit aliens. (a) Transit aliens—general. An alien is classifiable as a nonimmigrant transit alien under INA 101(a) (15) (C) if the consular officer is...

  1. 8 CFR 236.13 - Ineligible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligible aliens. 236.13 Section 236.13 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED Family Unity Program §...

  2. 8 CFR 211.5 - Alien commuters.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... shall be made in accordance with 8 CFR 264.5. ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Alien commuters. 211.5 Section 211.5 Aliens...: IMMIGRANTS; WAIVERS § 211.5 Alien commuters. (a) General. An alien lawfully admitted for permanent...

  3. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for...

  4. Captured by Aliens

    NASA Astrophysics Data System (ADS)

    Achenbach, Joel

    2000-03-01

    Captured by Aliens is a long and twisted voyage from science to the supernatural and back again. I hung out in Roswell, N.M., spent time with the Mars Society, met a guy who was figuring out the best way to build a spaceship to go to Alpha Centauri. I visited the set of the X-Files and talked to Mulder and Scully. One day over breakfast I was told by NASA administrator Dan Goldin, We live in a fog, man! He wants the big answers to the big questions. I spent a night in the base of a huge radio telescope in the boondocks of West Virginia, awaiting the signal from the aliens. I was hypnotized in a hotel room by someone who suspected that I'd been abducted by aliens and that this had triggered my interest in the topic. In the last months of his life, I talked to Carl Sagan, who believed that the galaxy riots with intelligent civilizations. He's my hero, for his steadfast adherence to the scientific method. What I found in all this is that the big question that needs immediate attention is not what's out THERE, but what's going on HERE, on Earth, and why we think the way we do, and how we came to be here in the first place.

  5. Star Wars testing and the ABM treaty

    SciTech Connect

    Bunn, M.

    1988-04-01

    In the defense authorization act, Congress has limited testing of the Strategic Defense Initiative (SDI) to those tests described by the Defense Department as within the bounds of the traditional interpretation of the treaty through fiscal year 1988. For the moment, the administration cannot move to implement its broad interpretation of the ABM Treaty, which would allow unlimited testing of exotic-technology Star Wars systems. Unfortunately, this victory over the broad interpretation is threatened by the administration's twisting of the traditional view. By stretching ambiguities in the treaty's language, the Defense Department is attempting to justify tests that press far into grey areas. A strong case can be made that some of the tests currently planned are likely to violate a reasonable reading of the traditional interpretation of the treaty. Other planned tests, while complying with the letter of the treaty, are clear efforts to circumvent the agreement's intent, undermining the effectiveness of the treaty regime. If the US justifies such tests by making unverifiable distinctions and exploiting loopholes, we will have no grounds for complaint when the USSR does the same, and we will ultimately lose the security benefits provided by the ABM Treaty. To clarify the compliance issues raised by SDI's current plans, this analysis describes the major past and planned SDI tests that may affect the ABM Treaty Regime.

  6. 26 CFR 1.846-4T - Effective dates (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Effective dates (temporary). 1.846-4T Section 1.846-4T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Other Insurance Companies § 1.846-4T Effective dates (temporary). (a) . For...

  7. Desperately seeking aliens

    NASA Astrophysics Data System (ADS)

    Aldiss, Brian W.

    2001-02-01

    Belief that intelligent life is commonplace in the Universe was taken for granted by scholars and scientists until well into the nineteenth century. Space travel since the late 1950s reignited the debate, which even now attracts discussion by serious, professional scientists. And although statisticians might lobby that life must surely exist somewhere in the Universe, the evolution of what we perceive as 'intelligent life' seems utterly improbable - elsewhere as well as on Earth. Can we free ourselves of our animist fantasies and accept that all alien forms of intelligent life are, and always have been, imaginary?

  8. Characteristics of successful alien plants.

    PubMed

    van Kleunen, M; Dawson, W; Maurel, N

    2015-05-01

    Herbert Baker arguably initiated the search for species characteristics determining alien plant invasion success, with his formulation of the 'ideal weed'. Today, a profusion of studies has tested a myriad of traits for their importance in explaining success of alien plants, but the multiple, not always appropriate, approaches used have led to some confusion and criticism. We argue that a greater understanding of the characteristics explaining alien plant success requires a refined approach that respects the multistage, multiscale nature of the invasion process. We present a schema of questions we can ask regarding the success of alien species, with the answering of one question in the schema being conditional on the answer of preceding questions (thus acknowledging the nested nature of invasion stages). For each question, we identify traits and attributes of species we believe are likely to be most important in explaining species success, and we make predictions as to how we expect successful aliens to differ from natives and from unsuccessful aliens in their characteristics. We organize the findings of empirical studies according to the questions in our schema that they have addressed, to assess the extent to which they support our predictions. We believe that research on plant traits of alien species has already told us a lot about why some alien species become successful after introduction. However, if we ask the right questions at the appropriate scale and use appropriate comparators, research on traits may tell us whether they are really important or not, and if so under which conditions. PMID:25421056

  9. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An...

  10. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An...

  11. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens....

  12. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens....

  13. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An...

  14. 28 CFR 21.3 - Aliens.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Aliens. 21.3 Section 21.3 Judicial Administration DEPARTMENT OF JUSTICE WITNESS FEES § 21.3 Aliens. (a) Aliens entitled to payment of $30 per day. The following aliens are entitled to witness fees and allowances provided in § 21.4: (1)...

  15. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens....

  16. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens....

  17. 28 CFR 21.3 - Aliens.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Aliens. 21.3 Section 21.3 Judicial Administration DEPARTMENT OF JUSTICE WITNESS FEES § 21.3 Aliens. (a) Aliens entitled to payment of $30 per day. The following aliens are entitled to witness fees and allowances provided in § 21.4: (1)...

  18. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An...

  19. 28 CFR 21.3 - Aliens.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Aliens. 21.3 Section 21.3 Judicial Administration DEPARTMENT OF JUSTICE WITNESS FEES § 21.3 Aliens. (a) Aliens entitled to payment of $30 per day. The following aliens are entitled to witness fees and allowances provided in § 21.4: (1)...

  20. 28 CFR 21.3 - Aliens.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Aliens. 21.3 Section 21.3 Judicial Administration DEPARTMENT OF JUSTICE WITNESS FEES § 21.3 Aliens. (a) Aliens entitled to payment of $30 per day. The following aliens are entitled to witness fees and allowances provided in § 21.4: (1)...

  1. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An...

  2. 28 CFR 21.3 - Aliens.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Aliens. 21.3 Section 21.3 Judicial Administration DEPARTMENT OF JUSTICE WITNESS FEES § 21.3 Aliens. (a) Aliens entitled to payment of $30 per day. The following aliens are entitled to witness fees and allowances provided in § 21.4: (1)...

  3. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens....

  4. 50 CFR 300.95 - Treaty Indian fisheries.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... or engaged in any activity related to fishing the treaty Indian identification required by 25 CFR 249... REGULATIONS Fraser River Sockeye and Pink Salmon Fisheries § 300.95 Treaty Indian fisheries. (a) Any treaty Indian must comply with this section when fishing for sockeye and pink salmon at the treaty Indian...

  5. 50 CFR 300.95 - Treaty Indian fisheries.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... or engaged in any activity related to fishing the treaty Indian identification required by 25 CFR 249... REGULATIONS Fraser River Sockeye and Pink Salmon Fisheries § 300.95 Treaty Indian fisheries. (a) Any treaty Indian must comply with this section when fishing for sockeye and pink salmon at the treaty Indian...

  6. 50 CFR 660.518 - Pacific Coast Treaty Indian Rights.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Pacific Coast Treaty Indian Rights. 660... Pelagics Fisheries § 660.518 Pacific Coast Treaty Indian Rights. (a) Pacific Coast treaty Indian tribes... the purposes of this section, “Pacific Coast treaty Indian tribes” and their “usual and...

  7. 50 CFR 660.518 - Pacific Coast Treaty Indian Rights.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Pacific Coast Treaty Indian Rights. 660... Pelagics Fisheries § 660.518 Pacific Coast Treaty Indian Rights. (a) Pacific Coast treaty Indian tribes... the purposes of this section, “Pacific Coast treaty Indian tribes” and their “usual and...

  8. 50 CFR 660.324 - Pacific Coast treaty Indian fisheries.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... tribal consensus. (e) Identification. A valid treaty Indian identification card issued pursuant to 25 CFR... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Pacific Coast treaty Indian fisheries. 660... Groundfish Fisheries § 660.324 Pacific Coast treaty Indian fisheries. (a) Pacific Coast treaty Indian...

  9. 50 CFR 660.518 - Pacific Coast Treaty Indian Rights.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Pacific Coast Treaty Indian Rights. 660... Pelagics Fisheries § 660.518 Pacific Coast Treaty Indian Rights. (a) Pacific Coast treaty Indian tribes... the purposes of this section, “Pacific Coast treaty Indian tribes” and their “usual and...

  10. Why Do Countries Commit to Human Rights Treaties?

    ERIC Educational Resources Information Center

    Hathaway, Oona A.

    2007-01-01

    This article examines states' decisions to commit to human rights treaties. It argues that the effect of a treaty on a state--and hence the state's willingness to commit to it--is largely determined by the domestic enforcement of the treaty and the treaty's collateral consequences. These broad claims give rise to several specific predictions. For…

  11. Non-proliferation treaty at 25

    SciTech Connect

    Cooper, M.H.

    1995-01-27

    In April, negotiators from more than 160 countries will meet in New York to decide the fate of the 25-year-old Nuclear Non-Proliferation Treaty (NPT). Under the agreement`s unusual terms, signatories must decide whether to extend it indefinitely, extend it for a specified period or abandon it. Supporters of a permanent NPT, including the United States, warn that instability in the post-Cold War era makes it all the more necessary to prevent rogue nations or terrorists from acquiring nuclear weapons. Critics, especially countries without nuclear weapons, say the treaty unfairly guarantees military superiority to the NPT`s five-member {open_quotes}nuclear club.{close_quotes} They also charge the nuclear powers, especially the United States and Russia, with not living up to the treaty`s requirement that they vigorously seek to halt the arms race and eliminate nuclear weapons.

  12. Honouring indigenous treaty rights for climate justice

    NASA Astrophysics Data System (ADS)

    Mantyka-Pringle, C. S.; Westman, C. N.; Kythreotis, A. P.; Schindler, D. W.

    2015-09-01

    Expansion of the oil sands industry in Canada has caused land destruction and social friction. Canada could become a leader in climate governance by honouring treaty commitments made with indigenous peoples.

  13. Alien Hand Syndrome.

    PubMed

    Hassan, Anhar; Josephs, Keith A

    2016-08-01

    Alien hand syndrome (AHS) is a rare disorder of involuntary limb movement together with a sense of loss of limb ownership. It most commonly affects the hand, but can occur in the leg. The anterior (frontal, callosal) and posterior variants are recognized, with distinguishing clinical features and anatomical lesions. Initial descriptions were attributed to stroke and neurosurgical operations, but neurodegenerative causes are now recognized as most common. Structural and functional imaging and clinical studies have implicated the supplementary motor area, pre-supplementary motor area, and their network connections in the frontal variant of AHS, and the inferior parietal lobule and connections in the posterior variant. Several theories are proposed to explain the pathophysiology. Herein, we review the literature to update advances in the understanding of the classification, pathophysiology, etiology, and treatment of AHS. PMID:27315251

  14. Allergen-Specific CD4(+) T Cells in Human Asthma.

    PubMed

    Ling, Morris F; Luster, Andrew D

    2016-03-01

    In allergic asthma, aeroallergen exposure of sensitized individuals mobilizes robust innate and adaptive airway immune responses, stimulating eosinophilic airway inflammation and the activation and infiltration of allergen-specific CD4(+) T cells into the airways. Allergen-specific CD4(+) T cells are thought to be central players in the asthmatic response as they specifically recognize the allergen and initiate and orchestrate the asthmatic inflammatory response. In this article, we briefly review the role of allergen-specific CD4(+) T cells in the pathogenesis of human allergic airway inflammation in allergic individuals, discuss the use of allergen-major histocompatibility complex class II tetramers to characterize allergen-specific CD4(+) T cells, and highlight current gaps in knowledge and directions for future research pertaining to the role of allergen-specific CD4(+) T cells in human asthma. PMID:27027948

  15. Impact of sepsis on CD4 T cell immunity

    PubMed Central

    Cabrera-Perez, Javier; Condotta, Stephanie A.; Badovinac, Vladimir P.; Griffith, Thomas S.

    2014-01-01

    Sepsis remains the primary cause of death from infection in hospital patients, despite improvements in antibiotics and intensive-care practices. Patients who survive severe sepsis can display suppressed immune function, often manifested as an increased susceptibility to (and mortality from) nosocomial infections. Not only is there a significant reduction in the number of various immune cell populations during sepsis, but there is also decreased function in the remaining lymphocytes. Within the immune system, CD4 T cells are important players in the proper development of numerous cellular and humoral immune responses. Despite sufficient clinical evidence of CD4 T cell loss in septic patients of all ages, the impact of sepsis on CD4 T cell responses is not well understood. Recent findings suggest that CD4 T cell impairment is a multipronged problem that results from initial sepsis-induced cell loss. However, the subsequent lymphopenia-induced numerical recovery of the CD4 T cell compartment leads to intrinsic alterations in phenotype and effector function, reduced repertoire diversity, changes in the composition of naive antigen-specific CD4 T cell pools, and changes in the representation of different CD4 T cell subpopulations (e.g., increases in Treg frequency). This review focuses on sepsis-induced alterations within the CD4 T cell compartment that influence the ability of the immune system to control secondary heterologous infections. The understanding of how sepsis affects CD4 T cells through their numerical loss and recovery, as well as function, is important in the development of future treatments designed to restore CD4 T cells to their presepsis state. PMID:24791959

  16. Treaty verification with an uncertain partner

    SciTech Connect

    Weissenberger, S.

    1991-01-01

    A simple model is used to analyze the performance of a system for verifying compliance with an arms control treaty. Blue and Red are partners in to a treaty. Blue prefers to comply, but is uncertain whether Red similarly prefers compliance (in the absence of threatened violation detection). Blue's uncertainty is modeled as a probability distribution over three different Red types: Violators, Compilers, and Deterrables. Criteria are derived to determine the level at which Blue should set his detection threshold, and when it is best for Blue not to verify at all. The results involve both game-theoretic and Bayes solutions. 9 refs., 14 figs.

  17. 8 CFR 1214.2 - Review of alien victims of severe forms of trafficking in persons; aliens in pending immigration...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Review of alien victims of severe forms of trafficking in persons; aliens in pending immigration proceedings. 1214.2 Section 1214.2 Aliens and... NONIMMIGRANT CLASSES § 1214.2 Review of alien victims of severe forms of trafficking in persons; aliens...

  18. 8 CFR 1214.2 - Review of alien victims of severe forms of trafficking in persons; aliens in pending immigration...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Review of alien victims of severe forms of trafficking in persons; aliens in pending immigration proceedings. 1214.2 Section 1214.2 Aliens and... NONIMMIGRANT CLASSES § 1214.2 Review of alien victims of severe forms of trafficking in persons; aliens...

  19. 8 CFR 1214.2 - Review of alien victims of severe forms of trafficking in persons; aliens in pending immigration...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Review of alien victims of severe forms of trafficking in persons; aliens in pending immigration proceedings. 1214.2 Section 1214.2 Aliens and... NONIMMIGRANT CLASSES § 1214.2 Review of alien victims of severe forms of trafficking in persons; aliens...

  20. 8 CFR 1214.2 - Review of alien victims of severe forms of trafficking in persons; aliens in pending immigration...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Review of alien victims of severe forms of trafficking in persons; aliens in pending immigration proceedings. 1214.2 Section 1214.2 Aliens and... NONIMMIGRANT CLASSES § 1214.2 Review of alien victims of severe forms of trafficking in persons; aliens...

  1. 8 CFR 1214.2 - Review of alien victims of severe forms of trafficking in persons; aliens in pending immigration...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Review of alien victims of severe forms of trafficking in persons; aliens in pending immigration proceedings. 1214.2 Section 1214.2 Aliens and... NONIMMIGRANT CLASSES § 1214.2 Review of alien victims of severe forms of trafficking in persons; aliens...

  2. Graffiti and "Film School" Culture: Displaying Alienation.

    ERIC Educational Resources Information Center

    Scheibel, Dean

    1994-01-01

    Examines graffiti created by students in "film school" as an organizational document. Finds themes related to alienation and the discourse that counters the sources of that alienation. Shows how the humorous communicative style of graffiti creates tension among cultural meanings that mediates between alienation and liberation. (SR)

  3. 33 CFR 125.25 - Aliens.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Aliens. 125.25 Section 125.25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) WATERFRONT....25 Aliens. Alien registration records together with other papers and documents which indicated...

  4. 33 CFR 125.25 - Aliens.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Aliens. 125.25 Section 125.25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) WATERFRONT....25 Aliens. Alien registration records together with other papers and documents which indicated...

  5. 43 CFR 3102.2 - Aliens.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Aliens. 3102.2 Section 3102.2 Public Lands... INTERIOR MINERALS MANAGEMENT (3000) OIL AND GAS LEASING Qualifications of Lessees § 3102.2 Aliens. Leases or interests therein may be acquired and held by aliens only through stock ownership, holding...

  6. 33 CFR 125.25 - Aliens.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Aliens. 125.25 Section 125.25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) WATERFRONT....25 Aliens. Alien registration records together with other papers and documents which indicated...

  7. 22 CFR 62.27 - Alien physicians.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Alien physicians. 62.27 Section 62.27 Foreign... Provisions § 62.27 Alien physicians. (a) Purpose. Pursuant to the Mutual Educational and Cultural Exchange... Foreign Medical Graduates must sponsor alien physicians who wish to pursue programs of graduate...

  8. 22 CFR 62.27 - Alien physicians.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Alien physicians. 62.27 Section 62.27 Foreign... Provisions § 62.27 Alien physicians. (a) Purpose. Pursuant to the Mutual Educational and Cultural Exchange... Foreign Medical Graduates must sponsor alien physicians who wish to pursue programs of graduate...

  9. 43 CFR 3102.2 - Aliens.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Aliens. 3102.2 Section 3102.2 Public Lands... INTERIOR MINERALS MANAGEMENT (3000) OIL AND GAS LEASING Qualifications of Lessees § 3102.2 Aliens. Leases or interests therein may be acquired and held by aliens only through stock ownership, holding...

  10. 33 CFR 125.25 - Aliens.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Aliens. 125.25 Section 125.25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) WATERFRONT....25 Aliens. Alien registration records together with other papers and documents which indicated...

  11. 43 CFR 3102.2 - Aliens.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Aliens. 3102.2 Section 3102.2 Public Lands... INTERIOR MINERALS MANAGEMENT (3000) OIL AND GAS LEASING Qualifications of Lessees § 3102.2 Aliens. Leases or interests therein may be acquired and held by aliens only through stock ownership, holding...

  12. Alienation, Dogmatism, and Related Personality Characteristics.

    ERIC Educational Resources Information Center

    Sexton, Miriam E.

    1983-01-01

    Examined the relationship between alienation and dogmatism, as measured by shared personality characteristics. Scores from the Rokeach Dogmatism Scale, the Keniston Alienation Scale, the California Test of Personality, and the Omnibus Personality Inventory were obtained for 92 college freshmen. Alienation and dogmatism were positively related…

  13. 43 CFR 3102.2 - Aliens.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Aliens. 3102.2 Section 3102.2 Public Lands... INTERIOR MINERALS MANAGEMENT (3000) OIL AND GAS LEASING Qualifications of Lessees § 3102.2 Aliens. Leases or interests therein may be acquired and held by aliens only through stock ownership, holding...

  14. 22 CFR 62.27 - Alien physicians.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Alien physicians. 62.27 Section 62.27 Foreign... Provisions § 62.27 Alien physicians. (a) Purpose. Pursuant to the Mutual Educational and Cultural Exchange... Foreign Medical Graduates must sponsor alien physicians who wish to pursue programs of graduate...

  15. 33 CFR 125.25 - Aliens.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Aliens. 125.25 Section 125.25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) WATERFRONT....25 Aliens. Alien registration records together with other papers and documents which indicated...

  16. Verifying the INF and START treaties

    SciTech Connect

    Ifft, Edward

    2014-05-09

    The INF and START Treaties form the basis for constraints on nuclear weapons. Their verification provisions are one of the great success stories of modern arms control and will be an important part of the foundation upon which the verification regime for further constraints on nuclear weapons will be constructed.

  17. Origins of the North Atlantic Treaty.

    ERIC Educational Resources Information Center

    Rotter, Andrew J.

    1983-01-01

    The author is persuaded that the main purpose of the North Atlantic Treaty Organization (NATO) was to raise the confidence of moderate ruling groups in Western Europe. Today NATO is an expression of support between troubled allies with a number of common interests. (RM)

  18. Indian Tribal Sovereignty and Treaty Rights.

    ERIC Educational Resources Information Center

    La Confluencia, Albuquerque, NM.

    Legal, philosophical, legislative, historical, and international aspects of the issue of Indian tribal sovereignty and treaty rights are presented in six articles based on transcripted proceedings of a forum held at San Diego State University April 12-14, 1978. In the introduction, Sam Deloria examines various definitions of tribal sovereignty. In…

  19. Verifying the INF and START treaties

    NASA Astrophysics Data System (ADS)

    Ifft, Edward

    2014-05-01

    The INF and START Treaties form the basis for constraints on nuclear weapons. Their verification provisions are one of the great success stories of modern arms control and will be an important part of the foundation upon which the verification regime for further constraints on nuclear weapons will be constructed.

  20. 78 FR 7759 - Patent Cooperation Treaty

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... Patent and Trademark Office Patent Cooperation Treaty ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and Trademark Office (USPTO), as part of its continuing effort to reduce...: Susan K. Fawcett, Records Officer, Office of the Chief Information Officer, United States Patent...

  1. 50 CFR 660.518 - Pacific Coast Treaty Indian Rights.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Pacific Coast Treaty Indian Rights. 660... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES Coastal Pelagics Fisheries § 660.518 Pacific Coast Treaty Indian Rights. (a) Pacific Coast treaty Indian...

  2. 50 CFR 660.518 - Pacific Coast Treaty Indian Rights.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Pacific Coast Treaty Indian Rights. 660... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES Coastal Pelagics Fisheries § 660.518 Pacific Coast Treaty Indian Rights. (a) Pacific Coast treaty Indian...

  3. 22 CFR 120.31 - North Atlantic Treaty Organization.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false North Atlantic Treaty Organization. 120.31 Section 120.31 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.31 North Atlantic Treaty Organization. North Atlantic Treaty Organization (NATO)...

  4. 21 CFR 1308.46 - Control required under international treaty.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Control required under international treaty. 1308... CONTROLLED SUBSTANCES Hearings § 1308.46 Control required under international treaty. Pursuant to section 201... under international treaties, conventions, or protocols in effect on May 1, 1971, the...

  5. 50 CFR 660.50 - Pacific Coast treaty Indian fisheries.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... issued pursuant to 25 CFR part 249, subpart A, is prima facie evidence that the holder is a member of the... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Pacific Coast treaty Indian fisheries... Groundfish Fisheries § 660.50 Pacific Coast treaty Indian fisheries. (a) Pacific Coast treaty Indian...

  6. 50 CFR 660.50 - Pacific Coast treaty Indian fisheries.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... issued pursuant to 25 CFR part 249, subpart A, is prima facie evidence that the holder is a member of the... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Pacific Coast treaty Indian fisheries. 660... Groundfish Fisheries § 660.50 Pacific Coast treaty Indian fisheries. (a) Pacific Coast treaty Indian...

  7. 50 CFR 660.50 - Pacific Coast treaty Indian fisheries.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... issued pursuant to 25 CFR part 249, subpart A, is prima facie evidence that the holder is a member of the... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Pacific Coast treaty Indian fisheries... Groundfish Fisheries § 660.50 Pacific Coast treaty Indian fisheries. (a) Pacific Coast treaty Indian...

  8. 21 CFR 1308.46 - Control required under international treaty.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Control required under international treaty. 1308... CONTROLLED SUBSTANCES Hearings § 1308.46 Control required under international treaty. Pursuant to section 201... under international treaties, conventions, or protocols in effect on May 1, 1971, the...

  9. 21 CFR 1308.46 - Control required under international treaty.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Control required under international treaty. 1308... CONTROLLED SUBSTANCES Hearings § 1308.46 Control required under international treaty. Pursuant to section 201... under international treaties, conventions, or protocols in effect on May 1, 1971, the...

  10. 21 CFR 1308.46 - Control required under international treaty.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Control required under international treaty. 1308... CONTROLLED SUBSTANCES Hearings § 1308.46 Control required under international treaty. Pursuant to section 201... under international treaties, conventions, or protocols in effect on May 1, 1971, the...

  11. 21 CFR 1308.46 - Control required under international treaty.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Control required under international treaty. 1308... CONTROLLED SUBSTANCES Hearings § 1308.46 Control required under international treaty. Pursuant to section 201... international treaties, conventions, or protocols in effect on May 1, 1971, the Administrator shall issue...

  12. 22 CFR 120.31 - North Atlantic Treaty Organization.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false North Atlantic Treaty Organization. 120.31 Section 120.31 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.31 North Atlantic Treaty Organization. North Atlantic Treaty Organization (NATO)...

  13. 22 CFR 120.31 - North Atlantic Treaty Organization.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false North Atlantic Treaty Organization. 120.31 Section 120.31 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.31 North Atlantic Treaty Organization. North Atlantic Treaty Organization (NATO)...

  14. 22 CFR 120.31 - North Atlantic Treaty Organization.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false North Atlantic Treaty Organization. 120.31 Section 120.31 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.31 North Atlantic Treaty Organization. North Atlantic Treaty Organization (NATO)...

  15. 22 CFR 120.31 - North Atlantic Treaty Organization.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false North Atlantic Treaty Organization. 120.31 Section 120.31 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.31 North Atlantic Treaty Organization. North Atlantic Treaty Organization (NATO)...

  16. 48 CFR 225.7902 - Defense Trade Cooperation Treaties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Defense Trade Cooperation Treaties. 225.7902 Section 225.7902 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Trade Cooperation Treaties. This section implements the Defense Trade Cooperation (DTC) Treaties...

  17. 48 CFR 225.7902 - Defense Trade Cooperation Treaties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Defense Trade Cooperation Treaties. 225.7902 Section 225.7902 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Trade Cooperation Treaties. This section implements the Defense Trade Cooperation (DTC) Treaties...

  18. 26 CFR 1.894-1 - Income affected by treaty.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Income affected by treaty. 1.894-1 Section 1.894-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.894-1 Income affected by treaty. (a) Income exempt under treaty. Income of any kind...

  19. 26 CFR 1.894-1 - Income affected by treaty.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Income affected by treaty. 1.894-1 Section 1.894-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Miscellaneous Provisions § 1.894-1 Income affected by treaty. (a) Income exempt under treaty. Income of any kind is not...

  20. 26 CFR 1.894-1 - Income affected by treaty.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 9 2012-04-01 2012-04-01 false Income affected by treaty. 1.894-1 Section 1.894-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.894-1 Income affected by treaty. (a) Income exempt under treaty. Income of any kind...

  1. 26 CFR 1.894-1 - Income affected by treaty.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 9 2014-04-01 2014-04-01 false Income affected by treaty. 1.894-1 Section 1.894-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.894-1 Income affected by treaty. (a) Income exempt under treaty. Income of any kind...

  2. 26 CFR 1.894-1 - Income affected by treaty.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 9 2013-04-01 2013-04-01 false Income affected by treaty. 1.894-1 Section 1.894-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.894-1 Income affected by treaty. (a) Income exempt under treaty. Income of any kind...

  3. Functional and Phenotypic Plasticity of CD4+ T Cell Subsets

    PubMed Central

    Caza, Tiffany; Landas, Steve

    2015-01-01

    The remarkable plasticity of CD4+ T cells allows individuals to respond to environmental stimuli in a context-dependent manner. A balance of CD4+ T cell subsets is critical to mount responses against pathogen challenges to prevent inappropriate activation, to maintain tolerance, and to participate in antitumor immune responses. Specification of subsets is a process beginning in intrathymic development and continuing within the circulation. It is highly flexible to adapt to differences in nutrient availability and the tissue microenvironment. CD4+ T cell subsets have significant cross talk, with the ability to “dedifferentiate” given appropriate environmental signals. This ability is dependent on the metabolic status of the cell, with mTOR acting as the rheostat. Autoimmune and antitumor immune responses are regulated by the balance between regulatory T cells and Th17 cells. When a homeostatic balance of subsets is not maintained, immunopathology can result. CD4+ T cells carry complex roles within tumor microenvironments, with context-dependent immune responses influenced by oncogenic drivers and the presence of inflammation. Here, we examine the signals involved in CD4+ T cell specification towards each subset, interconnectedness of cytokine networks, impact of mTOR signaling, and cellular metabolism in lineage specification and provide a supplement describing techniques to study these processes. PMID:26583116

  4. ALIENS IN WESTERN STREAM ECOSYSTEMS

    EPA Science Inventory

    The USEPA's Environmental Monitoring and Assessment Program conducted a five year probability sample of permanent mapped streams in 12 western US states. The study design enables us to determine the extent of selected riparian invasive plants, alien aquatic vertebrates, and some ...

  5. The Mexican "Illegal Alien" Commute.

    ERIC Educational Resources Information Center

    Decker, Phil

    1986-01-01

    A photo report of the following three treks by illegal aliens across the border from Mexico to work in Arizona reveals the dangers and disappointments the migrants are exposed to: (1) a "carpool" from Southern Mexico; (2) a train ride from Sinaloa; and (3) a 40-mile hike through the Arizona desert. (PS)

  6. The Creative Use of Alienation.

    ERIC Educational Resources Information Center

    Herrick, James E.

    The process of becoming a world citizen requires, as a first step, personal alienation from the cultural values and social arrangements of nation-states that stand in the way of such an effort. Three interrelated propositions underlie this thesis. First, prevailing cultural values and social arrangements severely limit opportunities for people to…

  7. Transcriptional Regulatory Networks for CD4 T Cell Differentiation

    PubMed Central

    Zhu, Jinfang

    2015-01-01

    CD4+ T cells play a central role in controlling the adaptive immune response by secreting cytokines to activate target cells. Naïve CD4+ T cells differentiate into at least four subsets, Th1, Th2, Th17, and inducible regulatory T cells, each with unique functions for pathogen elimination. The differentiation of these subsets is induced in response to cytokine stimulation, which is translated into Stat activation, followed by induction of master regulator transcription factors. In addition to these factors, multiple other transcription factors, both subset specific and shared, are also involved in promoting subset differentiation. This review will focus on the network of transcription factors that control CD4+ T cell differentiation. PMID:24839135

  8. Searching for Alien Life Having Unearthly Biochemistry

    NASA Technical Reports Server (NTRS)

    Jones, Harry

    2003-01-01

    The search for alien life in the solar system should include exploring unearth-like environments for life having an unearthly biochemistry. We expect alien life to conform to the same basic chemical and ecological constraints as terrestrial life, since inorganic chemistry and the laws of ecosystems appear to be universal. Astrobiologists usually assume alien life will use familiar terrestrial biochemistry and therefore hope to find alien life by searching near water or by supplying hydrocarbons. The assumption that alien life is likely to be based on carbon and water is traditional and plausible. It justifies high priority for missions to search for alien life on Mars and Europa, but it unduly restricts the search for alien life. Terrestrial carbon-water biochemistry is not possible on most of the bodies of our solar system, but all alien life is not necessarily based on terrestrial biochemistry. If alien life has a separate origin from Earth life, and if can survive in an environment extremely different from Earth's, then alien life may have unearthly biochemistry. There may be other solvents than water that support alien life and other elements than carbon that form complex life enabling chain molecules. Rather than making the exploration-restricting assumption that all life requires carbon, water, and terrestrial biochemistry, we should make the exploration-friendly assumption that indigenous, environmentally adapted, alien life forms might flourish using unearthly biochemistry in many places in the solar system. Alien life might be found wherever there is free energy and a physical/chemical system capable of using that energy to build living structures. Alien life may be discovered by the detection of some general non-equilibrium chemistry rather than of terrestrial biochemistry. We should explore all the potential abodes of life in the solar system, including those where life based on terrestrial biochemistry can not exist.

  9. Treaty to Curb Mercury Pollution Adopted

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2013-10-01

    The international Minamata Convention on Mercury to protect human health and the environment from anthropogenic emissions and releases of mercury and mercury compounds was formally adopted at a 10 October meeting in Minamata, Japan. The legally binding treaty, currently signed by 92 countries, comes 57 years after the government of Japan officially acknowledged, in 1956, the existence of Minamata disease, which was caused by eating seafood contaminated with methylmercury compounds discharged into Minamata Bay in southern Japan.

  10. Verifying arms control treaties to deter violations

    SciTech Connect

    Strait, R.S.; Judd, B.R.

    1988-06-23

    Verification has developed into a very important arms control issue. As evidenced by the recent Senate debates concerning ratification of the INF Treaty, verification can be a very controversial and emotional topic. In addition, verification's importance will surely continue for the foreseeable future. It is a major issue in the negotiations toward large reductions in strategic weapons and will gain even greater importance should deeper cuts be considered. 34 refs., 7 figs.

  11. 22 CFR 42.22 - Returning resident aliens.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Returning resident aliens. 42.22 Section 42.22... Returning resident aliens. (a) Requirements for returning resident status. An alien shall be classifiable as... presented that: (1) The alien had the status of an alien lawfully admitted for permanent residence at...

  12. 8 CFR 236.2 - Confined aliens, incompetents, and minors.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Confined aliens, incompetents, and minors. 236.2 Section 236.2 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED...

  13. 22 CFR 42.22 - Returning resident aliens.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Returning resident aliens. 42.22 Section 42.22... Returning resident aliens. (a) Requirements for returning resident status. An alien shall be classifiable as... presented that: (1) The alien had the status of an alien lawfully admitted for permanent residence at...

  14. 22 CFR 42.22 - Returning resident aliens.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Returning resident aliens. 42.22 Section 42.22... Returning resident aliens. (a) Requirements for returning resident status. An alien shall be classifiable as... presented that: (1) The alien had the status of an alien lawfully admitted for permanent residence at...

  15. 8 CFR 236.2 - Confined aliens, incompetents, and minors.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Confined aliens, incompetents, and minors. 236.2 Section 236.2 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED...

  16. 22 CFR 42.22 - Returning resident aliens.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Returning resident aliens. 42.22 Section 42.22... Returning resident aliens. (a) Requirements for returning resident status. An alien shall be classifiable as... presented that: (1) The alien had the status of an alien lawfully admitted for permanent residence at...

  17. 22 CFR 42.22 - Returning resident aliens.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Returning resident aliens. 42.22 Section 42.22... Returning resident aliens. (a) Requirements for returning resident status. An alien shall be classifiable as... presented that: (1) The alien had the status of an alien lawfully admitted for permanent residence at...

  18. [A case of parental alienation].

    PubMed

    Menz, Wolfgang

    2014-01-01

    The clinical term "Parental Alienation Syndrome" (PAS) was introduced in 1984 by Richard Gardner, an American psychiatrist. Gardner described PAS and its symptoms, as a personality disorder, which appears chiefly in connection to child custody disputes wherein a child turns suddenly and massively against the non-custodial parent without reasonable grounds for doing so. This action by the child is a result of the custodial parent's emotionally abusive attempts to incite the child against the non-custodial parent.Where the child's rejection is based on some real past experience, there is not PAS. PAS only occurs as a result of the custodial parent's actions. Despite intensive effort, PAS was not included in the new DSM-V. In this case, a particularly impressive case history of parental alienation is described and discussed. PMID:24464865

  19. Alien liquid detector and control

    SciTech Connect

    Potter, B.M.

    1980-09-02

    An alien liquid detector employs a monitoring element and an energizing circuit for maintaining the temperature of the monitoring element substantially above ambient temperature. For this purpose an electronic circit controls a flow of heating current to the monitoring element. The presence of an alien liquid is detected by sensing a predetermined change in heating current flow to the monitoring element, e.g., to distinguish between water and oil. In preferred embodiments the monitoring element is a thermistor whose resistance is compared with a reference resistance and heating current through the thermistor is controlled in accordance with the difference. In one embodiment a bridge circuit senses the resistance difference; the difference may be sensed by an operational amplifier arrangement. Features of the invention include positioning the monitoring element at the surface of water, slightly immersed, so that the power required to maintain the thermistor temperature substantially above ambient temperature serves to detect presence of oil pollution at the surface.

  20. Asymmetrical alien hands in corticobasal degeneration.

    PubMed

    Fitzgerald, David B; Drago, Valeria; Jeong, Yong; Chang, Yu-Ling; White, Keith D; Heilman, Kenneth M

    2007-03-15

    There are several forms of alien limb, but alien limb in corticobasal degeneration (CBD) is not well understood. We studied a patient with CBD who demonstrated two different types of alien limb. With his right hand he demonstrated a tactile avoidance response with levitation. With his left hand, he demonstrated continuous tactile pursuit of the examiner's hand ("tactile mitgehen"). Mitgehen is often associated with frontal dysfunction, but avoidance response and levitation are often associated with parietal dysfunction. PMID:17230447

  1. Index of Alien Impact: A method for evaluating potential ecological impact of alien plant species

    EPA Science Inventory

    Alien plant species are stressors to ecosystems and indicators of reduced ecosystem integrity. The magnitude of the stress reflects not only the quantity of aliens present, but also the quality of their interactions with native ecosystems. We develop an Index of Alien Impact (IAI...

  2. Adolescents' perceptions toward the internet: a 4-T framework.

    PubMed

    Tsai, Chin-Chung

    2004-08-01

    This study could be viewed as one of the initial attempts to probe adolescents' general perceptions toward the Internet. Through interviewing 40 adolescents in Taiwan, this study found the following 4-T categories for interpreting their perceptions toward the Internet, which included Technology, Tool, Toy, and Travel. Most adolescents perceived the Internet as a tool, implying that these adolescents, in general, held pragmatic views about the Internet. This paper further proposes a framework to elaborate the 4-T categories. The framework consists of the following two axes: one axis probably shows the ontology of the Internet, ranging from a "product" to a "process," whereas the other axis indicates the perceived feature of the Internet, varying from "functional" to "technical." It is finally suggested to carefully investigate the effects of people's Internet perceptions on their behaviors, as well as psychological and cognitive activities in Internet-related environments. PMID:15331033

  3. Assessing Proposals for New Global Health Treaties: An Analytic Framework

    PubMed Central

    Røttingen, John-Arne; Frenk, Julio

    2015-01-01

    We have presented an analytic framework and 4 criteria for assessing when global health treaties have reasonable prospects of yielding net positive effects. First, there must be a significant transnational dimension to the problem being addressed. Second, the goals should justify the coercive nature of treaties. Third, proposed global health treaties should have a reasonable chance of achieving benefits. Fourth, treaties should be the best commitment mechanism among the many competing alternatives. Applying this analytic framework to 9 recent calls for new global health treaties revealed that none fully meet the 4 criteria. Efforts aiming to better use or revise existing international instruments may be more productive than is advocating new treaties. PMID:26066926

  4. Assessing Proposals for New Global Health Treaties: An Analytic Framework.

    PubMed

    Hoffman, Steven J; Røttingen, John-Arne; Frenk, Julio

    2015-08-01

    We have presented an analytic framework and 4 criteria for assessing when global health treaties have reasonable prospects of yielding net positive effects. First, there must be a significant transnational dimension to the problem being addressed. Second, the goals should justify the coercive nature of treaties. Third, proposed global health treaties should have a reasonable chance of achieving benefits. Fourth, treaties should be the best commitment mechanism among the many competing alternatives. Applying this analytic framework to 9 recent calls for new global health treaties revealed that none fully meet the 4 criteria. Efforts aiming to better use or revise existing international instruments may be more productive than is advocating new treaties. PMID:26066926

  5. 9.4T Human MRI: Preliminary Results

    PubMed Central

    Vaughan, Thomas; DelaBarre, Lance; Snyder, Carl; Tian, Jinfeng; Akgun, Can; Shrivastava, Devashish; Liu, Wanzahn; Olson, Chris; Adriany, Gregor; Strupp, John; Andersen, Peter; Gopinath, Anand; van de Moortele, Pierre-Francois; Garwood, Michael; Ugurbil, Kamil

    2014-01-01

    This work reports the preliminary results of the first human images at the new high-field benchmark of 9.4T. A 65-cm-diameter bore magnet was used together with an asymmetric 40-cm-diameter head gradient and shim set. A multichannel transmission line (transverse electromagnetic (TEM)) head coil was driven by a programmable parallel transceiver to control the relative phase and magnitude of each channel independently. These new RF field control methods facilitated compensation for RF artifacts attributed to destructive interference patterns, in order to achieve homogeneous 9.4T head images or localize anatomic targets. Prior to FDA investigational device exemptions (IDEs) and internal review board (IRB)-approved human studies, preliminary RF safety studies were performed on porcine models. These data are reported together with exit interview results from the first 44 human volunteers. Although several points for improvement are discussed, the preliminary results demonstrate the feasibility of safe and successful human imaging at 9.4T. PMID:17075852

  6. Heterogeneity of Human CD4(+) T Cells Against Microbes.

    PubMed

    Sallusto, Federica

    2016-05-20

    CD4(+) T helper (Th) cells play a central role in the adaptive immune response by providing help to B cells and cytotoxic T cells and by releasing different types of cytokines in tissues to mediate protection against a wide range of pathogenic microorganisms. These functions are performed by different types of Th cells endowed with distinct migratory capacities and effector functions. Here we discuss how studies of the human T cell response to microbes have advanced our understanding of Th cell functional heterogeneity, in particular with the discovery of a distinct Th1 subset involved in the response to Mycobacteria and the characterization of two types of Th17 cells specific for extracellular bacteria or fungi. We also review new approaches to dissect at the clonal level the human CD4(+) T cell response induced by pathogens or vaccines that have revealed an unexpected degree of intraclonal diversification and propose a progressive and selective model of CD4(+) T cell differentiation. PMID:27168241

  7. Explaining patterns in the ratification of global environmental treaties

    NASA Technical Reports Server (NTRS)

    Cook, David W.

    1991-01-01

    A study was made of the ratification behavior of 160 countries with respect to 38 global environmental treaties. The study identifies and explains patterns in the ratification of treaties, providing two means of assessing the likelihood that any given country will support global environmental treaties. National ratification totals reveal a pattern of high ratification by countries in Western Europe, North America, Japan, Australia, and New Zealand. A country's standing within the range of high to low ratification rates can be explained by the statistical model developed in the study. This research allows one to identify countries likely to support global environmental treaties.

  8. Non-Proliferation Treaty at 25

    SciTech Connect

    Cooper, M.H.

    1995-01-20

    This article is a review of nuclear nonproliferation issues during the 25 years that have passed since the signing of the first nonproliferation treaty. A historical background is provided, both declared and undeclared nuclear powers are noted, and considerable attention is given to issues brought about by the dissolution of the Soviet Union and by the renegade actions of a number of signatories, e.g. Iraq, and several of the non-signatories. Present/future policies are discussed, as is the impact of the present Administration in Washington.

  9. Senators appear skeptical of ABM treaty modifications

    SciTech Connect

    Lockwood, D.

    1994-04-01

    At a March 10 Senate Foreign Relations Committee hearing, several senators questioned the wisdom of the Clinton administration`s proposal to try to {open_quotes}clarify{close_quotes} a key provision in the Anti-Ballistic Missile (ABM) Treaty that would permit the development and deployment of highly capable theater ballistic missile interceptors. The senators stressed that the executive branch should not try to change the pact in this manner without Senate approval. In response to questions, Arms Control and Disarmament Agency (ACDA) Director John Holum said without the proposed changes, the United States may not test new anti-tactical ballistic missile (ATBM) defense systems currently under development.

  10. Alienation and Expectation in American Political Culture.

    ERIC Educational Resources Information Center

    Ranney, Austin

    The concept of political alienation in American culture is examined in light of evidence gathered by social scientists. Political alienation is interpreted to include a wide variety of attitudes and behaviors such as cynicism, outraged idealism, apathy, violent protest, powerlessness, and revolutionary zeal. To minimize conceptual ambiguities of…

  11. Alienating Students: Marxist Theory in Action

    ERIC Educational Resources Information Center

    Thiele, Megan; Pan, Yung-Yi Dian; Molina, Devin

    2016-01-01

    Karl Marx's revolutionary call, "Workers of the World Unite," resonates with many in today's society. This article describes and assesses an easily reproducible classroom activity that simulates both alienating, and perhaps more importantly, non-alienating states of production as described by Marx. This hands-on learning activity gives…

  12. Alienation and Use of the Mass Media.

    ERIC Educational Resources Information Center

    Pietila, Veikko

    Several studies in media viewing have examined the hypothesis that alienation correlates with the consumption of escape-type content from the mass media. In order to interpret this result, alienation was considered as a process beginning with difficiulties in situation definitions. It was assumed in this study that heavy information of the mass…

  13. Alienation, Mass Society and Mass Culture.

    ERIC Educational Resources Information Center

    Dam, Hari N.

    This monograph examines the nature of alienation in mass society and mass culture. Conceptually based on the "Gemeinschaft-Gesellschaft" paradigm of sociologist Ferdinand Tonnies, discussion traces the concept of alienation as it appears in the philosophies of Hegel, Marx, Kierkegaard, Sartre, and others. Dwight Macdonald's "A Theory of Mass…

  14. Alienation in the Barrio: Eastern New Mexico.

    ERIC Educational Resources Information Center

    Donnelly, Jerry D.

    Preliminary to a larger research project on Mexican American attitudes, this report focused on the extent to which feelings of alienation are present in the barrios of 5 eastern New Mexico population centers. The feelings of alienation were analyzed by the degree of powerlessness, normlessness, self-estrangement, and isolation expressed or…

  15. Alienation, dogmatism, and related personality characteristics.

    PubMed

    Sexton, M E

    1983-01-01

    Examined the relationship between alienation and dogmatism, as measured by shared personality characteristics. Scores from the Rokeach Dogmatism Scale, the Keniston Alienation Scale, the California Test of Personality, and the Omnibus Personality Inventory were obtained for a sample of 92 college freshmen. Alienation and dogmatism were found to be positively related concepts. The factors that best predicted alienation from dogmatic responses were intolerance expressed for opposing beliefs and compulsivity in the belief system. Alienation and dogmatism also were found to be associated with several commonly held personality traits, which center around anxiety, low self-esteem, and social estrangement manifested in feelings of hostility, aggression, loneliness, rejection, and isolation. These results were discussed and compared to previous research that explored the two concepts separately. PMID:6826758

  16. 50 CFR 660.706 - Pacific Coast Treaty Indian rights.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) (u&a grounds for groundfish); 50 CFR 300.64(i) (u&a grounds for halibut)). The u&a grounds recognized... valid treaty Indian identification card issued pursuant to 25 CFR part 249, subpart A, is prima facie... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Pacific Coast Treaty Indian rights....

  17. 50 CFR 660.706 - Pacific Coast Treaty Indian rights.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) (u&a grounds for groundfish); 50 CFR 300.64(i) (u&a grounds for halibut)). The u&a grounds recognized... valid treaty Indian identification card issued pursuant to 25 CFR part 249, subpart A, is prima facie... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Pacific Coast Treaty Indian rights....

  18. Understanding Indian Treaties as Law: Peace and Friendship.

    ERIC Educational Resources Information Center

    Barsh, Russel Lawrence

    This unit presents information on Native American treaties as a basis for rational thought on current controversies over these treaties' status. The unit contains three sections with five lesson plans each. Each lesson includes student material, goals, vocabulary, and questions for discussion. Section 1 covers (1) the purposes of government, and…

  19. 76 FR 72245 - Implementation of Defense Trade Cooperation Treaties

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ...The Department of State is proposing to amend the International Traffic in Arms Regulations (ITAR) to implement the Defense Trade Cooperation Treaty between the United States and Australia and the Defense Trade Cooperation Treaty between the United States and the United Kingdom, and identify via a supplement the defense articles and defense services that may not be exported pursuant to the......

  20. 50 CFR 660.706 - Pacific Coast Treaty Indian rights.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) (u&a grounds for groundfish); 50 CFR 300.64(i) (u&a grounds for halibut)). The u&a grounds recognized... valid treaty Indian identification card issued pursuant to 25 CFR part 249, subpart A, is prima facie... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Pacific Coast Treaty Indian rights....

  1. 50 CFR 660.706 - Pacific Coast Treaty Indian rights.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) (u&a grounds for groundfish); 50 CFR 300.64(i) (u&a grounds for halibut)). The u&a grounds recognized... valid treaty Indian identification card issued pursuant to 25 CFR part 249, subpart A, is prima facie... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Pacific Coast Treaty Indian rights....

  2. 50 CFR 660.706 - Pacific Coast Treaty Indian rights.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) (u&a grounds for groundfish); 50 CFR 300.64(i) (u&a grounds for halibut)). The u&a grounds recognized... valid treaty Indian identification card issued pursuant to 25 CFR part 249, subpart A, is prima facie... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Pacific Coast Treaty Indian rights....

  3. The Seven Nations of Canada: An Alliance and a Treaty.

    ERIC Educational Resources Information Center

    Blanchard, David

    1983-01-01

    Provides cultural and historical context for understanding the Seven Nations Treaty of 1796. Clarifies terms of the treaty that continues to provide a source of conflict between the Mohawk Nation and the State of New York, e.g., the 1974 reoccupation of some Adirondak land by a Mohawk group. (JHZ)

  4. 50 CFR 300.95 - Treaty Indian fisheries.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... or engaged in any activity related to fishing the treaty Indian identification required by 25 CFR 249... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Treaty Indian fisheries. 300.95 Section 300.95 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL...

  5. 50 CFR 300.95 - Treaty Indian fisheries.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... or engaged in any activity related to fishing the treaty Indian identification required by 25 CFR 249... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Treaty Indian fisheries. 300.95 Section 300.95 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL...

  6. 50 CFR 300.95 - Treaty Indian fisheries.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... or engaged in any activity related to fishing the treaty Indian identification required by 25 CFR 249... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Treaty Indian fisheries. 300.95 Section 300.95 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL...

  7. Lessons in American Indian History. IV: The Treaties

    ERIC Educational Resources Information Center

    Weewish Tree, 1975

    1975-01-01

    There were 271 treaties made between the United States Government and many Indian Nations, promising friendship and peaceful interaction, but treaty amendments and outright violations on the part of the United States led to war and loss of Indian Nation lands. (JC)

  8. Functional aortic stiffness: role of CD4+ T lymphocytes

    PubMed Central

    Majeed, Beenish A.; Eberson, Lance S.; Tawinwung, Supannikar; Larmonier, Nicolas; Secomb, Timothy W.; Larson, Douglas F.

    2015-01-01

    The immune system is suggested to be essential in vascular remodeling and stiffening. To study the dependence upon lymphocytes in vascular stiffening, we compared an angiotensin II-model of vascular stiffening in normal C57BL/6J mice with lymphocyte-deficient RAG 1−/− mice and additionally characterized the component of vascular stiffness due to vasoconstriction vs. vascular remodeling. Chronic angiotensin II increased aortic pulse wave velocity, effective wall stiffness, and effective Young's modulus in C57BL/6J mice by three-fold but caused no change in the RAG 1−/− mice. These functional measurements were supported by aortic morphometric analysis. Adoptive transfer of CD4+ T helper lymphocytes restored the angiotensin II-mediated aortic stiffening in the RAG 1−/− mice. In order to account for the hydraulic vs. material effects of angiotensin II on pulse wave velocity, subcutaneous osmotic pumps were removed after 21 days of angiotensin II-infusion in the WT mice to achieve normotensive values. The pulse wave velocity (PWV) decreased from three- to two-fold above baseline values up to 7 days following pump removal. This study supports the pivotal role of the CD4+ T-lymphocytes in angiotensin II-mediated vascular stiffening and that angiotensin II-mediated aortic stiffening is due to the additive effect of active vascular smooth muscle vasoconstriction and vascular remodeling. PMID:26379554

  9. The CFE Treaty and changed conditions in Europe

    SciTech Connect

    Allentuck, J.

    1994-08-01

    The Treaty on Conventional Forces in Europe (CFE) was signed in November 1990 by sixteen nations, members of the North Atlantic Treaty Organization (NATO), and six nations, members of the Warsaw Treaty Organization (WTO). It was resigned to prevent a major surprise attack in Europe by the conventional forces of one Treaty Organization against those of the other and was the first major arms control treaty to address conventional weapons. This paper focuses on how CFE adapted to changes in the military-political situation in Europe which occurred after 1990 and failed to adapt to others. Suggestions are offered on how it might be changed to make it more relevant under these changed conditions.

  10. 31 CFR 515.335 - Permanent resident alien.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Permanent resident alien. 515.335... Definitions § 515.335 Permanent resident alien. As used in § 515.208, the term permanent resident alien means an alien lawfully admitted for permanent residence into the United States....

  11. 45 CFR 233.52 - Overpayment to aliens.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Overpayment to aliens. 233.52 Section 233.52... ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.52 Overpayment to aliens. A State Plan under title IV-A of the Social Security Act, shall provide that: (a) Any sponsor of an alien and the alien shall...

  12. 26 CFR 1.6654-6 - Nonresident alien individuals.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Nonresident alien individuals. 1.6654-6 Section... Penalties § 1.6654-6 Nonresident alien individuals. (a) In general. A nonresident alien individual is... the gross income of a nonresident alien individual is such as to require making a payment of...

  13. 22 CFR 40.91 - Certain aliens previously removed.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Certain aliens previously removed. 40.91... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.91 Certain aliens previously removed. (a) 5-year bar. An alien who has been found inadmissible, whether as a...

  14. 47 CFR 90.115 - Foreign government and alien eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Foreign government and alien eligibility. 90... government and alien eligibility. (a) No station authorization in the radio services governed by this part....9(c) of this chapter) if such entity is: (1) An alien or the representative of any alien; (2)...

  15. 8 CFR 274a.3 - Continuing employment of unauthorized aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Continuing employment of unauthorized aliens. 274a.3 Section 274a.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROL OF EMPLOYMENT OF ALIENS Employer Requirements § 274a.3 Continuing employment...

  16. 22 CFR 40.92 - Aliens unlawfully present.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Aliens unlawfully present. 40.92 Section 40.92... UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.92 Aliens unlawfully present. (a) 3-year bar. An alien described in INA 212(a)(9)(B)(i)(I) shall be ineligible for...

  17. 45 CFR 233.52 - Overpayment to aliens.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Overpayment to aliens. 233.52 Section 233.52 Public... ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.52 Overpayment to aliens. A State Plan under title IV-A of the Social Security Act, shall provide that: (a) Any sponsor of an alien and the alien shall...

  18. 8 CFR 1240.38 - Fingerprinting of excluded aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Fingerprinting of excluded aliens. 1240.38 Section 1240.38 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Exclusion...

  19. 45 CFR 1626.7 - Verification of eligible alien status.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Verification of eligible alien status. 1626.7... CORPORATION RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.7 Verification of eligible alien status. (a) An alien seeking representation shall submit appropriate documents to verify eligibility, unless the...

  20. 45 CFR 1626.5 - Alien status and eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Alien status and eligibility. 1626.5 Section 1626... RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.5 Alien status and eligibility. Subject to all other... may provide legal assistance to an alien who is present in the United States and who is within one...

  1. 31 CFR 515.335 - Permanent resident alien.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Permanent resident alien. 515.335... Definitions § 515.335 Permanent resident alien. As used in § 515.208, the term permanent resident alien means an alien lawfully admitted for permanent residence into the United States....

  2. 26 CFR 1.871-3 - Residence of alien seamen.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Residence of alien seamen. 1.871-3 Section 1.871... (CONTINUED) INCOME TAXES Nonresident Aliens and Foreign Corporations § 1.871-3 Residence of alien seamen. In order to determine whether an alien seaman is a resident of the United States for purposes of the...

  3. 45 CFR 1626.5 - Alien status and eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Alien status and eligibility. 1626.5 Section 1626... RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.5 Alien status and eligibility. Subject to all other... may provide legal assistance to an alien who is present in the United States and who is within one...

  4. 8 CFR 1236.2 - Confined aliens, incompetents, and minors.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...(c) of 8 CFR chapter I. (b) Service custody and cost of maintenance. An alien confined because of... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Confined aliens, incompetents, and minors. 1236.2 Section 1236.2 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT...

  5. 26 CFR 1.6654-6 - Nonresident alien individuals.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Nonresident alien individuals. 1.6654-6 Section... Penalties § 1.6654-6 Nonresident alien individuals. (a) In general. A nonresident alien individual is... the gross income of a nonresident alien individual is such as to require making a payment of...

  6. 8 CFR 1240.38 - Fingerprinting of excluded aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Fingerprinting of excluded aliens. 1240.38 Section 1240.38 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Exclusion...

  7. 8 CFR 1236.2 - Confined aliens, incompetents, and minors.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...(c) of 8 CFR chapter I. (b) Service custody and cost of maintenance. An alien confined because of... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Confined aliens, incompetents, and minors. 1236.2 Section 1236.2 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT...

  8. 26 CFR 1.871-3 - Residence of alien seamen.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 9 2013-04-01 2013-04-01 false Residence of alien seamen. 1.871-3 Section 1.871... (CONTINUED) INCOME TAXES (CONTINUED) Nonresident Aliens and Foreign Corporations § 1.871-3 Residence of alien seamen. In order to determine whether an alien seaman is a resident of the United States for purposes...

  9. 22 CFR 40.92 - Aliens unlawfully present.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Aliens unlawfully present. 40.92 Section 40.92... UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.92 Aliens unlawfully present. (a) 3-year bar. An alien described in INA 212(a)(9)(B)(i)(I) shall be ineligible for...

  10. 26 CFR 1.871-3 - Residence of alien seamen.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 9 2012-04-01 2012-04-01 false Residence of alien seamen. 1.871-3 Section 1.871... (CONTINUED) INCOME TAXES (CONTINUED) Nonresident Aliens and Foreign Corporations § 1.871-3 Residence of alien seamen. In order to determine whether an alien seaman is a resident of the United States for purposes...

  11. 22 CFR 40.91 - Certain aliens previously removed.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Certain aliens previously removed. 40.91... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.91 Certain aliens previously removed. (a) 5-year bar. An alien who has been found inadmissible, whether as a...

  12. 8 CFR 274a.3 - Continuing employment of unauthorized aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Continuing employment of unauthorized aliens. 274a.3 Section 274a.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROL OF EMPLOYMENT OF ALIENS Employer Requirements § 274a.3 Continuing employment...

  13. 8 CFR 1236.2 - Confined aliens, incompetents, and minors.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...(c) of 8 CFR chapter I. (b) Service custody and cost of maintenance. An alien confined because of... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Confined aliens, incompetents, and minors. 1236.2 Section 1236.2 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT...

  14. 26 CFR 1.6654-6 - Nonresident alien individuals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Nonresident alien individuals. 1.6654-6 Section....6654-6 Nonresident alien individuals. (a) In general. A nonresident alien individual is required to... gross income of a nonresident alien individual is such as to require making a payment of...

  15. 8 CFR 1236.2 - Confined aliens, incompetents, and minors.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...(c) of 8 CFR chapter I. (b) Service custody and cost of maintenance. An alien confined because of... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Confined aliens, incompetents, and minors. 1236.2 Section 1236.2 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT...

  16. 26 CFR 1.6654-6 - Nonresident alien individuals.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 13 2011-04-01 2011-04-01 false Nonresident alien individuals. 1.6654-6 Section... Penalties § 1.6654-6 Nonresident alien individuals. (a) In general. A nonresident alien individual is... the gross income of a nonresident alien individual is such as to require making a payment of...

  17. 45 CFR 1626.5 - Alien status and eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Alien status and eligibility. 1626.5 Section 1626... RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.5 Alien status and eligibility. Subject to all other... may provide legal assistance to an alien who is present in the United States and who is within one...

  18. 26 CFR 1.871-3 - Residence of alien seamen.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Residence of alien seamen. 1.871-3 Section 1.871... (CONTINUED) INCOME TAXES (CONTINUED) Nonresident Aliens and Foreign Corporations § 1.871-3 Residence of alien seamen. In order to determine whether an alien seaman is a resident of the United States for purposes...

  19. 22 CFR 40.91 - Certain aliens previously removed.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Certain aliens previously removed. 40.91... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.91 Certain aliens previously removed. (a) 5-year bar. An alien who has been found inadmissible, whether as a...

  20. 47 CFR 90.115 - Foreign government and alien eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Foreign government and alien eligibility. 90... government and alien eligibility. (a) No station authorization in the radio services governed by this part....9(c) of this chapter) if such entity is: (1) An alien or the representative of any alien; (2)...

  1. 8 CFR 1240.38 - Fingerprinting of excluded aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Fingerprinting of excluded aliens. 1240.38 Section 1240.38 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Exclusion...

  2. 8 CFR 1240.38 - Fingerprinting of excluded aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Fingerprinting of excluded aliens. 1240.38 Section 1240.38 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Exclusion...

  3. 45 CFR 1626.7 - Verification of eligible alien status.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Verification of eligible alien status. 1626.7... CORPORATION RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.7 Verification of eligible alien status. (a) An alien seeking representation shall submit appropriate documents to verify eligibility, unless the...

  4. 22 CFR 40.92 - Aliens unlawfully present.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Aliens unlawfully present. 40.92 Section 40.92... UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.92 Aliens unlawfully present. (a) 3-year bar. An alien described in INA 212(a)(9)(B)(i)(I) shall be ineligible for...

  5. 8 CFR 274a.3 - Continuing employment of unauthorized aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Continuing employment of unauthorized aliens. 274a.3 Section 274a.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROL OF EMPLOYMENT OF ALIENS Employer Requirements § 274a.3 Continuing employment...

  6. 47 CFR 90.115 - Foreign government and alien eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Foreign government and alien eligibility. 90... government and alien eligibility. (a) No station authorization in the radio services governed by this part....9(c) of this chapter) if such entity is: (1) An alien or the representative of any alien; (2)...

  7. 31 CFR 515.335 - Permanent resident alien.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Permanent resident alien. 515.335... Definitions § 515.335 Permanent resident alien. As used in § 515.208, the term permanent resident alien means an alien lawfully admitted for permanent residence into the United States....

  8. 45 CFR 1626.5 - Alien status and eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Alien status and eligibility. 1626.5 Section 1626... RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.5 Alien status and eligibility. Subject to all other... may provide legal assistance to an alien who is present in the United States and who is within one...

  9. 45 CFR 233.52 - Overpayment to aliens.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Overpayment to aliens. 233.52 Section 233.52... ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.52 Overpayment to aliens. A State Plan under title IV-A of the Social Security Act, shall provide that: (a) Any sponsor of an alien and the alien shall...

  10. 45 CFR 1626.7 - Verification of eligible alien status.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Verification of eligible alien status. 1626.7... CORPORATION RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.7 Verification of eligible alien status. (a) An alien seeking representation shall submit appropriate documents to verify eligibility, unless the...

  11. 31 CFR 515.335 - Permanent resident alien.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Permanent resident alien. 515.335... Definitions § 515.335 Permanent resident alien. As used in § 515.208, the term permanent resident alien means an alien lawfully admitted for permanent residence into the United States....

  12. 45 CFR 1626.7 - Verification of eligible alien status.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Verification of eligible alien status. 1626.7... CORPORATION RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.7 Verification of eligible alien status. (a) An alien seeking representation shall submit appropriate documents to verify eligibility, unless the...

  13. 28 CFR 0.47 - Alien property matters.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Alien property matters. 0.47 Section 0.47....47 Alien property matters. The Office of Alien Property shall be a part of the Civil Division: (a... Alien Property: (1) Exercising or performing all the authority, rights, privileges, powers, duties,...

  14. 22 CFR 40.92 - Aliens unlawfully present.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Aliens unlawfully present. 40.92 Section 40.92... UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.92 Aliens unlawfully present. (a) 3-year bar. An alien described in INA 212(a)(9)(B)(i)(I) shall be ineligible for...

  15. 45 CFR 233.52 - Overpayment to aliens.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Overpayment to aliens. 233.52 Section 233.52... ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.52 Overpayment to aliens. A State Plan under title IV-A of the Social Security Act, shall provide that: (a) Any sponsor of an alien and the alien shall...

  16. 22 CFR 40.91 - Certain aliens previously removed.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Certain aliens previously removed. 40.91... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.91 Certain aliens previously removed. (a) 5-year bar. An alien who has been found inadmissible, whether as a...

  17. 8 CFR 274a.3 - Continuing employment of unauthorized aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Continuing employment of unauthorized aliens. 274a.3 Section 274a.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROL OF EMPLOYMENT OF ALIENS Employer Requirements § 274a.3 Continuing employment...

  18. 47 CFR 90.115 - Foreign government and alien eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Foreign government and alien eligibility. 90... government and alien eligibility. (a) No station authorization in the radio services governed by this part....9(c) of this chapter) if such entity is: (1) An alien or the representative of any alien; (2)...

  19. 7 CFR 273.4 - Citizenship and alien status.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... residing in the same household as the alien at the time of the abuse, an alien whose child has been... residing in the same household as the alien at the time of the abuse, an alien whose child has been... Laotian who is deceased, or (iii) An unmarried dependent child of such Hmong or Highland Laotian who...

  20. 7 CFR 273.4 - Citizenship and alien status.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... residing in the same household as the alien at the time of the abuse, an alien whose child has been... residing in the same household as the alien at the time of the abuse, an alien whose child has been... Laotian who is deceased, or (iii) An unmarried dependent child of such Hmong or Highland Laotian who...

  1. 7 CFR 273.4 - Citizenship and alien status.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... residing in the same household as the alien at the time of the abuse, an alien whose child has been... residing in the same household as the alien at the time of the abuse, an alien whose child has been... Laotian who is deceased, or (iii) An unmarried dependent child of such Hmong or Highland Laotian who...

  2. 7 CFR 273.4 - Citizenship and alien status.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... residing in the same household as the alien at the time of the abuse, an alien whose child has been... residing in the same household as the alien at the time of the abuse, an alien whose child has been... Laotian who is deceased, or (iii) An unmarried dependent child of such Hmong or Highland Laotian who...

  3. 26 CFR 1.871-3 - Residence of alien seamen.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 9 2014-04-01 2014-04-01 false Residence of alien seamen. 1.871-3 Section 1.871... (CONTINUED) INCOME TAXES (CONTINUED) Nonresident Aliens and Foreign Corporations § 1.871-3 Residence of alien seamen. In order to determine whether an alien seaman is a resident of the United States for purposes...

  4. 45 CFR 233.52 - Overpayment to aliens.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Overpayment to aliens. 233.52 Section 233.52 Public... ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.52 Overpayment to aliens. A State Plan under title IV-A of the Social Security Act, shall provide that: (a) Any sponsor of an alien and the alien shall...

  5. 31 CFR 515.335 - Permanent resident alien.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Permanent resident alien. 515.335... Definitions § 515.335 Permanent resident alien. As used in § 515.208, the term permanent resident alien means an alien lawfully admitted for permanent residence into the United States....

  6. 8 CFR 1240.38 - Fingerprinting of excluded aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Fingerprinting of excluded aliens. 1240.38 Section 1240.38 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Exclusion...

  7. 22 CFR 40.92 - Aliens unlawfully present.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Aliens unlawfully present. 40.92 Section 40.92... UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.92 Aliens unlawfully present. (a) 3-year bar. An alien described in INA 212(a)(9)(B)(i)(I) shall be ineligible for...

  8. 47 CFR 90.115 - Foreign government and alien eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Foreign government and alien eligibility. 90... government and alien eligibility. (a) No station authorization in the radio services governed by this part....9(c) of this chapter) if such entity is: (1) An alien or the representative of any alien; (2)...

  9. 8 CFR 274a.3 - Continuing employment of unauthorized aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Continuing employment of unauthorized aliens. 274a.3 Section 274a.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROL OF EMPLOYMENT OF ALIENS Employer Requirements § 274a.3 Continuing employment...

  10. 45 CFR 1626.7 - Verification of eligible alien status.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Verification of eligible alien status. 1626.7... CORPORATION RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.7 Verification of eligible alien status. (a) An alien seeking representation shall submit appropriate documents to verify eligibility, unless the...

  11. 26 CFR 1.6654-6 - Nonresident alien individuals.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Nonresident alien individuals. 1.6654-6 Section... Penalties § 1.6654-6 Nonresident alien individuals. (a) In general. A nonresident alien individual is... the gross income of a nonresident alien individual is such as to require making a payment of...

  12. 8 CFR 1236.2 - Confined aliens, incompetents, and minors.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...(c) of 8 CFR chapter I. (b) Service custody and cost of maintenance. An alien confined because of... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Confined aliens, incompetents, and minors. 1236.2 Section 1236.2 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT...

  13. 22 CFR 40.91 - Certain aliens previously removed.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Certain aliens previously removed. 40.91... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.91 Certain aliens previously removed. (a) 5-year bar. An alien who has been found inadmissible, whether as a...

  14. The Role of science in treaty verification

    SciTech Connect

    Gavron, A. I.

    2004-01-01

    Technologically advanced nations are currently applying more science to treaty verification than ever before. Satellites gather a multitude of information relating to proliferation concerns using thermal imaging analysis, nuclear radiation measurements, and optical and radio frequency signals detection. Ground stations gather complementary signals such as seismic events and radioactive emissions. Export controls in many countries attempt to intercept materials and technical means that could be used for nuclear proliferation. Never the less, we have witnessed a plethora of nuclear proliferation episodes, that were undetected (or were belatedly detected) by these technologies - the Indian nuclear tests in 1998, the Libyan nuclear buildup, the Iranian enrichment program and the North Korea nuclear weapons program are some prime examples. In this talk we will discuss some of the technologies used for proliferation detection. In particular, we will note some of the issues relating to nuclear materials control agreements that epitomize political difficulties as they impact the implementation of science and technology.

  15. Understanding correlation coefficients in treaty verification

    SciTech Connect

    DeVolpi, A.

    1991-11-01

    When a pair of images are compared on a point-by-point basis, the linear-correlation coefficient is usually used as a measure of similarity or dissimilarity. This paper evaluates the theoretical underpinnings and limitation of the linear-correlation coefficient, as well as other related statistics, particularly for cases where inherent white noise is present. As a result of the limitations in linear-correlation, an additional step has been derived -- local-sum clustering -- in order to improve recognition of small dissimilarities in a pair images. Results show that three-stage procedure, consisting of first establishing congruence of the two images, than using the linear-correlation coefficient as a test of true negatives, and finally qualifying a true positive by using the cluster (local-sum) method. These algorithmic stages would be especially useful in arms control treaty verification.

  16. Plasticity of human CD4 T cell subsets.

    PubMed

    Geginat, Jens; Paroni, Moira; Maglie, Stefano; Alfen, Johanna Sophie; Kastirr, Ilko; Gruarin, Paola; De Simone, Marco; Pagani, Massimiliano; Abrignani, Sergio

    2014-01-01

    Human beings are exposed to a variety of different pathogens, which induce tailored immune responses and consequently generate highly diverse populations of pathogen-specific T cells. CD4(+) T cells have a central role in adaptive immunity, since they provide essential help for both cytotoxic T cell- and antibody-mediated responses. In addition, CD4(+) regulatory T cells are required to maintain self-tolerance and to inhibit immune responses that could damage the host. Initially, two subsets of CD4(+) helper T cells were identified that secrete characteristic effector cytokines and mediate responses against different types of pathogens, i.e., IFN-γ secreting Th1 cells that fight intracellular pathogens, and IL-4 producing Th2 cells that target extracellular parasites. It is now well established that this dichotomy is insufficient to describe the complexity of CD4(+) T cell differentiation, and in particular the human CD4 compartment contains a myriad of T cell subsets with characteristic capacities to produce cytokines and to home to involved tissues. Moreover, it has become increasingly clear that these T cell subsets are not all terminally differentiated cells, but that the majority is plastic and that in particular central memory T cells can acquire different properties and functions in secondary immune responses. In addition, there is compelling evidence that helper T cells can acquire regulatory functions upon chronic stimulation in inflamed tissues. The plasticity of antigen-experienced human T cell subsets is highly relevant for translational medicine, since it opens new perspectives for immune-modulatory therapies for chronic infections, autoimmune diseases, and cancer. PMID:25566245

  17. Plasticity of Human CD4 T Cell Subsets

    PubMed Central

    Geginat, Jens; Paroni, Moira; Maglie, Stefano; Alfen, Johanna Sophie; Kastirr, Ilko; Gruarin, Paola; De Simone, Marco; Pagani, Massimiliano; Abrignani, Sergio

    2014-01-01

    Human beings are exposed to a variety of different pathogens, which induce tailored immune responses and consequently generate highly diverse populations of pathogen-specific T cells. CD4+ T cells have a central role in adaptive immunity, since they provide essential help for both cytotoxic T cell- and antibody-mediated responses. In addition, CD4+ regulatory T cells are required to maintain self-tolerance and to inhibit immune responses that could damage the host. Initially, two subsets of CD4+ helper T cells were identified that secrete characteristic effector cytokines and mediate responses against different types of pathogens, i.e., IFN-γ secreting Th1 cells that fight intracellular pathogens, and IL-4 producing Th2 cells that target extracellular parasites. It is now well established that this dichotomy is insufficient to describe the complexity of CD4+ T cell differentiation, and in particular the human CD4 compartment contains a myriad of T cell subsets with characteristic capacities to produce cytokines and to home to involved tissues. Moreover, it has become increasingly clear that these T cell subsets are not all terminally differentiated cells, but that the majority is plastic and that in particular central memory T cells can acquire different properties and functions in secondary immune responses. In addition, there is compelling evidence that helper T cells can acquire regulatory functions upon chronic stimulation in inflamed tissues. The plasticity of antigen-experienced human T cell subsets is highly relevant for translational medicine, since it opens new perspectives for immune-modulatory therapies for chronic infections, autoimmune diseases, and cancer. PMID:25566245

  18. Hosts and parasites as aliens.

    PubMed

    Taraschewski, H

    2006-06-01

    Over the past decades, various free-living animals (hosts) and their parasites have invaded recipient areas in which they had not previously occurred, thus gaining the status of aliens or exotics. In general this happened to a low extent for hundreds of years. With variable frequency, invasions have been followed by the dispersal and establishment of non-indigenous species, whether host or parasite. In the literature thus far, colonizations by both hosts and parasites have not been treated and reviewed together, although both are usually interwoven in various ways. As to those factors permitting invasive success and colonization strength, various hypotheses have been put forward depending on the scientific background of respective authors and on the conspicuousness of certain invasions. Researchers who have tried to analyse characteristic developmental patterns, the speed of dispersal or the degree of genetic divergence in populations of alien species have come to different conclusions. Among parasitologists, the applied aspects of parasite invasions, such as the negative effects on economically important hosts, have long been at the centre of interest. In this contribution, invasions by hosts as well as parasites are considered comparatively, revealing many similarities and a few differences. Two helminths, the liver fluke, Fasciola hepatica, of cattle and sheep and the swimbladder nematode, Anguillicola crassus, of eels are shown to be useful as model parasites for the study of animal invasions and environmental global change. Introductions of F. hepatica have been associated with imports of cattle or other grazing animals. In various target areas, susceptible lymnaeid snails serving as intermediate hosts were either naturally present and/or were introduced from the donor continent of the parasite (Europe) and/or from other regions which were not within the original range of the parasite, partly reflecting progressive stages of a global biota change. In several

  19. Undocumented Aliens: A Study of Mexican Families.

    ERIC Educational Resources Information Center

    Salcido, Ramon M.

    1979-01-01

    The personal histories described here confirm that the primary impetus of undocumented aliens to emigrate is the desire for jobs and better socioeconomic opportunities. Amnesty, aid to families with dependent children, and increased social services are recommended. (Author/BEF)

  20. Distinct Translational Control in CD4+ T Cell Subsets

    PubMed Central

    Yurchenko, Ekaterina; Zheng, Lei; Gandin, Valentina; Topisirovic, Ivan; Li, Shui; Wagner, Carston R.; Sonenberg, Nahum; Piccirillo, Ciriaco A.

    2013-01-01

    Regulatory T cells expressing the transcription factor Foxp3 play indispensable roles for the induction and maintenance of immunological self-tolerance and immune homeostasis. Genome-wide mRNA expression studies have defined canonical signatures of T cell subsets. Changes in steady-state mRNA levels, however, often do not reflect those of corresponding proteins due to post-transcriptional mechanisms including mRNA translation. Here, we unveil a unique translational signature, contrasting CD4+Foxp3+ regulatory T (TFoxp3+) and CD4+Foxp3− non-regulatory T (TFoxp3−) cells, which imprints subset-specific protein expression. We further show that translation of eukaryotic translation initiation factor 4E (eIF4E) is induced during T cell activation and, in turn, regulates translation of cell cycle related mRNAs and proliferation in both TFoxp3− and TFoxp3+ cells. Unexpectedly, eIF4E also affects Foxp3 expression and thereby lineage identity. Thus, mRNA–specific translational control directs both common and distinct cellular processes in CD4+ T cell subsets. PMID:23658533

  1. 50 CFR 300.64 - Fishing by U.S. treaty Indian tribes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... treaty Indian fishing. (e) Ceremonial and subsistence fishing for halibut by treaty Indians in subarea 2A... ceremonial and subsistence fishing under this section must have on his or her person a valid treaty Indian identification card issued pursuant to 25 CFR part 249, subpart A, and must comply with the treaty Indian...

  2. 50 CFR 300.64 - Fishing by U.S. treaty Indian tribes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... treaty Indian fishing. (e) Ceremonial and subsistence fishing for halibut by treaty Indians in subarea 2A... ceremonial and subsistence fishing under this section must have on his or her person a valid treaty Indian identification card issued pursuant to 25 CFR part 249, subpart A, and must comply with the treaty Indian...

  3. Entering the digital era of the Open Skies Treaty

    NASA Astrophysics Data System (ADS)

    Orych, Agata

    2015-06-01

    The Open Skies Treaty has been a peace-building instrument between North American and European nations for over two decades. This agreement is based on the possibility for each country-signatory of the Treaty to independently conduct observation flights and obtain aerial imagery data of the territories of other Treaty States-Parties. This imagery data was originally acquired only using traditional photographic film cameras. Together with the rapid development and advancement of digital sensor technologies, the logical step forward was to amend the Treaty provisions to allow for the use of these types of sensors during observation missions. This paper describes this transition process and highlights a number of technical problems which needed to be addressed by experts working within the Open Skies Consultative Commission workgroups.

  4. Senate hearing considers Law of the Sea treaty

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2012-06-01

    The U.S. Senate Committee on Foreign Relations is once again discussing the Law of the Sea Convention (LOS). The treaty, which was adopted in 1982 by parties to a United Nations Conference as a framework for governing uses of the world's oceans, has been ratified by more than 160 countries, but the United States is a notable exception. The treaty has been approved twice by the Foreign Relations Committee but has not made it to a full Senate vote because of opponents' concerns about potential loss of U.S. sovereignty and U.S. access to the deep seabed, among other reasons. During a 23 May hearing of the committee, chairman John Kerry (D-Mass.), a strong supporter of the treaty, said U.S. ratification "is now more urgent than ever" and that to remain outside of the treaty "is fundamentally, directly counter to the best interests" of the United States.

  5. Micropatterning of costimulatory ligands enhances CD4+ T cell function

    PubMed Central

    Shen, Keyue; Thomas, V. Kaye; Dustin, Michael L.; Kam, Lance C.

    2008-01-01

    Spatial organization of signaling complexes is a defining characteristic of the immunological synapse (IS), but its impact on cell communication is unclear. In T cell–APC pairs, more IL-2 is produced when CD28 clusters are segregated from central supramolecular activation cluster (cSMAC)-localized CD3 and into the IS periphery. However, it is not clear in these cellular experiments whether the increased IL-2 is driven by the pattern itself or by upstream events that precipitate the patterns. In this article, we recapitulate key features of physiological synapses using planar costimulation arrays containing antibodies against CD3 and CD28, surrounded by ICAM-1, created by combining multiple rounds of microcontact printing on a single surface. Naïve T cells traverse these arrays, stopping at features of anti-CD3 antibodies and forming a stable synapse. We directly demonstrate that presenting anti-CD28 in the cell periphery, surrounding an anti-CD3 feature, enhances IL-2 secretion by naïve CD4+ T cells compared with having these signals combined in the center of the IS. This increased cytokine production correlates with NF-κB translocation and requires PKB/Akt signaling. The ability to arbitrarily and independently control the locations of anti-CD3 and anti-CD28 offered the opportunity to examine patterns not precisely attainable in cell–cell interfaces. With these patterns, we show that the peripheral presentation of CD28 has a larger impact on IL-2 secretion than CD3 colocalization/segregation. PMID:18505845

  6. 26 CFR 1.475(a)-4T - Valuation safe harbor (temporary).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 6 2012-04-01 2012-04-01 false Valuation safe harbor (temporary). 1.475(a)-4T Section 1.475(a)-4T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Inventories § 1.475(a)-4T Valuation safe harbor (temporary). (a) through (d)(4) introductory text...

  7. 26 CFR 1.905-4T - Notification of foreign tax redetermination (temporary).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 9 2014-04-01 2014-04-01 false Notification of foreign tax redetermination (temporary). 1.905-4T Section 1.905-4T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Income from Sources Without the United States § 1.905-4T Notification of foreign...

  8. 26 CFR 1.905-4T - Notification of foreign tax redetermination (temporary).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 9 2013-04-01 2013-04-01 false Notification of foreign tax redetermination (temporary). 1.905-4T Section 1.905-4T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Income from Sources Without the United States § 1.905-4T Notification of foreign...

  9. 26 CFR 1.905-4T - Notification of foreign tax redetermination (temporary).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 9 2012-04-01 2012-04-01 false Notification of foreign tax redetermination (temporary). 1.905-4T Section 1.905-4T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Income from Sources Without the United States § 1.905-4T Notification of foreign...

  10. 26 CFR 1.905-4T - Notification of foreign tax redetermination (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Notification of foreign tax redetermination (temporary). 1.905-4T Section 1.905-4T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Income from Sources Without the United States § 1.905-4T Notification of foreign...

  11. 26 CFR 1.6038D-4T - Information required to be reported (temporary).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Information required to be reported (temporary). 1.6038D-4T Section 1.6038D-4T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Information Returns § 1.6038D-4T Information required to be reported (temporary)....

  12. 8 CFR 274a.12 - Classes of aliens authorized to accept employment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Classes of aliens authorized to accept employment. 274a.12 Section 274a.12 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROL OF EMPLOYMENT OF ALIENS Employment Authorization § 274a.12 Classes of aliens authorized to accept employment. (a) Aliens...

  13. ALIEN SPECIES: THEIR ROLE IN AMPHIBIAN POPULATION DECLINES AND RESTORATION

    EPA Science Inventory

    Alien species (also referred to as exotic, invasive, introduced, or normative species) have been implicated as causal agents in population declines of many amphibian species. Herein, we evaluate the relative contributions of alien species and other factors in adversely affecting ...

  14. 32 CFR 1602.3 - Aliens and nationals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Aliens and nationals. 1602.3 Section 1602.3 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.3 Aliens and nationals. (a) The term alien means any person who is not a citizen or national of...

  15. 22 CFR 41.58 - Aliens in religious occupations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Aliens in religious occupations. 41.58 Section... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Business and Media Visas § 41.58 Aliens in religious occupations. (a) Requirements for “R” classification. An alien shall be classifiable under the provisions of...

  16. 20 CFR 404.1036 - Certain nonresident aliens.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Certain nonresident aliens. 404.1036 Section... Employment § 404.1036 Certain nonresident aliens. (a) Foreign students. (1) Foreign students (nonimmigrant aliens) may be temporarily in the United States under subparagraph (F) of section 101(a)(15) of...

  17. 8 CFR 1241.20 - Aliens ordered excluded.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., see 8 CFR 241.20 through 241.25. ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Aliens ordered excluded. 1241.20 Section 1241.20 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF...

  18. 42 CFR 436.330 - Coverage for certain aliens.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Coverage for certain aliens. 436.330 Section 436... Coverage of the Medically Needy § 436.330 Coverage for certain aliens. If an agency provides Medicaid to... condition, as defined in § 440.255(c) of this chapter to those aliens described in § 436.406(c) of...

  19. 45 CFR 233.51 - Eligibility of sponsored aliens.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Eligibility of sponsored aliens. 233.51 Section... CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.51 Eligibility of sponsored aliens... affidavit(s) of support or similar agreement on behalf of an alien (who is not the child of the sponsor...

  20. 8 CFR 236.2 - Confined aliens, incompetents, and minors.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....1 of this chapter upon the person or persons specified by 8 CFR 103.8(c). (b) Service custody and... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Confined aliens, incompetents, and minors. 236.2 Section 236.2 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION...

  1. 22 CFR 41.58 - Aliens in religious occupations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Aliens in religious occupations. 41.58 Section... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Business and Media Visas § 41.58 Aliens in religious occupations. (a) Requirements for “R” classification. An alien shall be classifiable under the provisions of...

  2. 45 CFR 233.51 - Eligibility of sponsored aliens.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Eligibility of sponsored aliens. 233.51 Section... CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.51 Eligibility of sponsored aliens... affidavit(s) of support or similar agreement on behalf of an alien (who is not the child of the sponsor...

  3. 8 CFR 1241.30 - Aliens ordered deported.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ordered deported, see 8 CFR 241.30 through 241.33. ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Aliens ordered deported. 1241.30 Section 1241.30 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF...

  4. 22 CFR 41.55 - Aliens with extraordinary ability.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Aliens with extraordinary ability. 41.55... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Business and Media Visas § 41.55 Aliens with extraordinary ability. (a) Requirements for O classification. An alien shall be classifiable under the provisions of INA...

  5. 45 CFR 233.51 - Eligibility of sponsored aliens.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Eligibility of sponsored aliens. 233.51 Section 233... CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.51 Eligibility of sponsored aliens... affidavit(s) of support or similar agreement on behalf of an alien (who is not the child of the sponsor...

  6. 8 CFR 1241.30 - Aliens ordered deported.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ordered deported, see 8 CFR 241.30 through 241.33. ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Aliens ordered deported. 1241.30 Section 1241.30 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF...

  7. 8 CFR 1241.20 - Aliens ordered excluded.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., see 8 CFR 241.20 through 241.25. ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Aliens ordered excluded. 1241.20 Section 1241.20 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF...

  8. 22 CFR 41.55 - Aliens with extraordinary ability.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Aliens with extraordinary ability. 41.55... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Business and Media Visas § 41.55 Aliens with extraordinary ability. (a) Requirements for O classification. An alien shall be classifiable under the provisions of INA...

  9. 20 CFR 404.1036 - Certain nonresident aliens.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Certain nonresident aliens. 404.1036 Section... Employment § 404.1036 Certain nonresident aliens. (a) Foreign students. (1) Foreign students (nonimmigrant aliens) may be temporarily in the United States under subparagraph (F) of section 101(a)(15) of...

  10. 42 CFR 436.128 - Coverage for certain qualified aliens.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Coverage for certain qualified aliens. 436.128... Mandatory Coverage of the Categorically Needy § 436.128 Coverage for certain qualified aliens. The agency... § 440.255(c) of this chapter to those aliens described in § 436.406(c) of this subpart....

  11. 42 CFR 436.128 - Coverage for certain qualified aliens.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Coverage for certain qualified aliens. 436.128... Mandatory Coverage of the Categorically Needy § 436.128 Coverage for certain qualified aliens. The agency... § 440.255(c) of this chapter to those aliens described in § 436.406(c) of this subpart....

  12. 45 CFR 233.51 - Eligibility of sponsored aliens.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Eligibility of sponsored aliens. 233.51 Section... CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.51 Eligibility of sponsored aliens... affidavit(s) of support or similar agreement on behalf of an alien (who is not the child of the sponsor...

  13. 42 CFR 436.330 - Coverage for certain aliens.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Coverage for certain aliens. 436.330 Section 436... Coverage of the Medically Needy § 436.330 Coverage for certain aliens. If an agency provides Medicaid to... condition, as defined in § 440.255(c) of this chapter to those aliens described in § 436.406(c) of...

  14. 8 CFR 1241.30 - Aliens ordered deported.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ordered deported, see 8 CFR 241.30 through 241.33. ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Aliens ordered deported. 1241.30 Section 1241.30 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF...

  15. 32 CFR 1602.3 - Aliens and nationals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Aliens and nationals. 1602.3 Section 1602.3 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.3 Aliens and nationals. (a) The term alien means any person who is not a citizen or national of...

  16. 22 CFR 41.55 - Aliens with extraordinary ability.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Aliens with extraordinary ability. 41.55... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Business and Media Visas § 41.55 Aliens with extraordinary ability. (a) Requirements for O classification. An alien shall be classifiable under the provisions of INA...

  17. 42 CFR 436.330 - Coverage for certain aliens.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Coverage for certain aliens. 436.330 Section 436... Coverage of the Medically Needy § 436.330 Coverage for certain aliens. If an agency provides Medicaid to... condition, as defined in § 440.255(c) of this chapter to those aliens described in § 436.406(c) of...

  18. 43 CFR 426.8 - Nonresident aliens and foreign entities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Nonresident aliens and foreign entities..., DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.8 Nonresident aliens and foreign... reclamation law or these regulations, a nonresident alien or foreign entity that directly holds land in...

  19. 22 CFR 40.9 - Classes of inadmissible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Classes of inadmissible aliens. 40.9 Section 40.9 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND... inadmissible aliens. Subparts B through L describe classes of inadmissible aliens who are ineligible to...

  20. 42 CFR 436.128 - Coverage for certain qualified aliens.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Coverage for certain qualified aliens. 436.128... Mandatory Coverage of the Categorically Needy § 436.128 Coverage for certain qualified aliens. The agency... § 440.255(c) of this chapter to those aliens described in § 436.406(c) of this subpart....

  1. 43 CFR 426.8 - Nonresident aliens and foreign entities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Nonresident aliens and foreign entities..., DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.8 Nonresident aliens and foreign... reclamation law or these regulations, a nonresident alien or foreign entity that directly holds land in...

  2. 42 CFR 435.139 - Coverage for certain aliens.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Coverage for certain aliens. 435.139 Section 435... Aliens § 435.139 Coverage for certain aliens. The agency must provide services necessary for the treatment of an emergency medical condition, as defined in § 440.255(c) of this chapter, to those...

  3. 22 CFR 41.58 - Aliens in religious occupations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Aliens in religious occupations. 41.58 Section... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Business and Media Visas § 41.58 Aliens in religious occupations. (a) Requirements for “R” classification. An alien shall be classifiable under the provisions of...

  4. 42 CFR 436.330 - Coverage for certain aliens.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Coverage for certain aliens. 436.330 Section 436... Coverage of the Medically Needy § 436.330 Coverage for certain aliens. If an agency provides Medicaid to... condition, as defined in § 440.255(c) of this chapter to those aliens described in § 436.406(c) of...

  5. 20 CFR 404.1036 - Certain nonresident aliens.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Certain nonresident aliens. 404.1036 Section... Employment § 404.1036 Certain nonresident aliens. (a) Foreign students. (1) Foreign students (nonimmigrant aliens) may be temporarily in the United States under subparagraph (F) of section 101(a)(15) of...

  6. 22 CFR 40.9 - Classes of inadmissible aliens.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Classes of inadmissible aliens. 40.9 Section 40.9 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND... inadmissible aliens. Subparts B through L describe classes of inadmissible aliens who are ineligible to...

  7. 42 CFR 435.139 - Coverage for certain aliens.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Coverage for certain aliens. 435.139 Section 435... Aliens § 435.139 Coverage for certain aliens. The agency must provide services necessary for the treatment of an emergency medical condition, as defined in § 440.255(c) of this chapter, to those...

  8. 43 CFR 426.8 - Nonresident aliens and foreign entities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Nonresident aliens and foreign entities..., DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.8 Nonresident aliens and foreign... reclamation law or these regulations, a nonresident alien or foreign entity that directly holds land in...

  9. 42 CFR 436.128 - Coverage for certain qualified aliens.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Coverage for certain qualified aliens. 436.128... Mandatory Coverage of the Categorically Needy § 436.128 Coverage for certain qualified aliens. The agency... § 440.255(c) of this chapter to those aliens described in § 436.406(c) of this subpart....

  10. 22 CFR 40.9 - Classes of inadmissible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Classes of inadmissible aliens. 40.9 Section 40.9 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND... inadmissible aliens. Subparts B through L describe classes of inadmissible aliens who are ineligible to...

  11. 8 CFR 236.2 - Confined aliens, incompetents, and minors.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ....1 of this chapter upon the person or persons specified by 8 CFR 103.8(c). (b) Service custody and... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Confined aliens, incompetents, and minors. 236.2 Section 236.2 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION...

  12. 42 CFR 435.139 - Coverage for certain aliens.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Coverage for certain aliens. 435.139 Section 435... ISLANDS, AND AMERICAN SAMOA Mandatory Coverage Mandatory Coverage of Certain Aliens § 435.139 Coverage for certain aliens. The agency must provide services necessary for the treatment of an emergency...

  13. 32 CFR 1602.3 - Aliens and nationals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Aliens and nationals. 1602.3 Section 1602.3 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.3 Aliens and nationals. (a) The term alien means any person who is not a citizen or national of...

  14. 22 CFR 41.58 - Aliens in religious occupations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Aliens in religious occupations. 41.58 Section... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Business and Media Visas § 41.58 Aliens in religious occupations. (a) Requirements for “R” classification. An alien shall be classifiable under the provisions of...

  15. 8 CFR 1241.30 - Aliens ordered deported.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ordered deported, see 8 CFR 241.30 through 241.33. ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Aliens ordered deported. 1241.30 Section 1241.30 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF...

  16. 42 CFR 435.139 - Coverage for certain aliens.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Coverage for certain aliens. 435.139 Section 435... Aliens § 435.139 Coverage for certain aliens. The agency must provide services necessary for the treatment of an emergency medical condition, as defined in § 440.255(c) of this chapter, to those...

  17. 8 CFR 1241.20 - Aliens ordered excluded.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., see 8 CFR 241.20 through 241.25. ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Aliens ordered excluded. 1241.20 Section 1241.20 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF...

  18. 20 CFR 404.1036 - Certain nonresident aliens.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Certain nonresident aliens. 404.1036 Section... Employment § 404.1036 Certain nonresident aliens. (a) Foreign students. (1) Foreign students (nonimmigrant aliens) may be temporarily in the United States under subparagraph (F) of section 101(a)(15) of...

  19. 32 CFR 1602.3 - Aliens and nationals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Aliens and nationals. 1602.3 Section 1602.3 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.3 Aliens and nationals. (a) The term alien means any person who is not a citizen or national of...

  20. 22 CFR 40.9 - Classes of inadmissible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Classes of inadmissible aliens. 40.9 Section 40.9 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND... inadmissible aliens. Subparts B through L describe classes of inadmissible aliens who are ineligible to...

  1. 43 CFR 426.8 - Nonresident aliens and foreign entities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Nonresident aliens and foreign entities..., DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.8 Nonresident aliens and foreign... reclamation law or these regulations, a nonresident alien or foreign entity that directly holds land in...

  2. 22 CFR 41.55 - Aliens with extraordinary ability.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Aliens with extraordinary ability. 41.55... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Business and Media Visas § 41.55 Aliens with extraordinary ability. (a) Requirements for O classification. An alien shall be classifiable under the provisions of INA...

  3. 8 CFR 1241.20 - Aliens ordered excluded.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., see 8 CFR 241.20 through 241.25. ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Aliens ordered excluded. 1241.20 Section 1241.20 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF...

  4. Socio-economic Predictors of Alienation among the Elderly.

    ERIC Educational Resources Information Center

    Durant, Thomas J., Jr.; Christian, Ollie

    1990-01-01

    Studied level of alienation and associations between socioeconomic variables and alienation in 200 older senior center clients. Found group isolation and powerlessness were more prevalent than personal isolation or normlessness; health, race, education, and income were strongest predictors of alienation; and older Blacks and those with lower…

  5. 28 CFR 0.47 - Alien property matters.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Alien property matters. 0.47 Section 0.47....47 Alien property matters. The Office of Alien Property shall be a part of the Civil Division: (a) The following described matters are assigned to, and shall be conducted, handled, or supervised by...

  6. 28 CFR 0.47 - Alien property matters.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Alien property matters. 0.47 Section 0.47....47 Alien property matters. The Office of Alien Property shall be a part of the Civil Division: (a) The following described matters are assigned to, and shall be conducted, handled, or supervised by...

  7. 28 CFR 0.47 - Alien property matters.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Alien property matters. 0.47 Section 0.47....47 Alien property matters. The Office of Alien Property shall be a part of the Civil Division: (a) The following described matters are assigned to, and shall be conducted, handled, or supervised by...

  8. 28 CFR 0.47 - Alien property matters.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Alien property matters. 0.47 Section 0.47....47 Alien property matters. The Office of Alien Property shall be a part of the Civil Division: (a) The following described matters are assigned to, and shall be conducted, handled, or supervised by...

  9. 8 CFR 1241.30 - Aliens ordered deported.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ordered deported, see 8 CFR 241.30 through 241.33. ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Aliens ordered deported. 1241.30 Section 1241.30 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF...

  10. 20 CFR 404.1036 - Certain nonresident aliens.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Certain nonresident aliens. 404.1036 Section... Employment § 404.1036 Certain nonresident aliens. (a) Foreign students. (1) Foreign students (nonimmigrant aliens) may be temporarily in the United States under subparagraph (F) of section 101(a)(15) of...

  11. 8 CFR 1241.20 - Aliens ordered excluded.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., see 8 CFR 241.20 through 241.25. ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Aliens ordered excluded. 1241.20 Section 1241.20 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF...

  12. 45 CFR 233.51 - Eligibility of sponsored aliens.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Eligibility of sponsored aliens. 233.51 Section 233... CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.51 Eligibility of sponsored aliens... affidavit(s) of support or similar agreement on behalf of an alien (who is not the child of the sponsor...

  13. 43 CFR 426.8 - Nonresident aliens and foreign entities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Nonresident aliens and foreign entities..., DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.8 Nonresident aliens and foreign... reclamation law or these regulations, a nonresident alien or foreign entity that directly holds land in...

  14. 22 CFR 41.55 - Aliens with extraordinary ability.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Aliens with extraordinary ability. 41.55... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Business and Media Visas § 41.55 Aliens with extraordinary ability. (a) Requirements for O classification. An alien shall be classifiable under the provisions of INA...

  15. 8 CFR 236.2 - Confined aliens, incompetents, and minors.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....1 of this chapter upon the person or persons specified by 8 CFR 103.8(c). (b) Service custody and... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Confined aliens, incompetents, and minors. 236.2 Section 236.2 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION...

  16. 22 CFR 41.58 - Aliens in religious occupations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Aliens in religious occupations. 41.58 Section... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Business and Media Visas § 41.58 Aliens in religious occupations. (a) Requirements for “R” classification. An alien shall be classifiable under the provisions of...

  17. 32 CFR 1602.3 - Aliens and nationals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Aliens and nationals. 1602.3 Section 1602.3 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.3 Aliens and nationals. (a) The term alien means any person who is not a citizen or national of...

  18. 22 CFR 40.9 - Classes of inadmissible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Classes of inadmissible aliens. 40.9 Section 40.9 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND... inadmissible aliens. Subparts B through L describe classes of inadmissible aliens who are ineligible to...

  19. 42 CFR 436.128 - Coverage for certain qualified aliens.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Coverage for certain qualified aliens. 436.128... Mandatory Coverage of the Categorically Needy § 436.128 Coverage for certain qualified aliens. The agency... § 440.255(c) of this chapter to those aliens described in § 436.406(c) of this subpart....

  20. 42 CFR 435.139 - Coverage for certain aliens.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Coverage for certain aliens. 435.139 Section 435... ISLANDS, AND AMERICAN SAMOA Mandatory Coverage Mandatory Coverage of Certain Aliens § 435.139 Coverage for certain aliens. The agency must provide services necessary for the treatment of an emergency...

  1. 42 CFR 436.330 - Coverage for certain aliens.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Coverage for certain aliens. 436.330 Section 436... Coverage of the Medically Needy § 436.330 Coverage for certain aliens. If an agency provides Medicaid to... condition, as defined in § 440.255(c) of this chapter to those aliens described in § 436.406(c) of...

  2. Systemic Disaffection: A Three-Factor Theory of Political Alienation.

    ERIC Educational Resources Information Center

    Long, Samuel

    The paper develops a theory of political alienation based upon interactions among three antecedent conditions. Political alienation is interpreted as combining feelings of inefficacy, discontent, cynicism, estrangement, and hopelessness. The factors evaluated for their contribution to political alienation are: (1) critical perceptions of…

  3. Alienation: A Concept for Understanding Low-Income, Urban Clients

    ERIC Educational Resources Information Center

    Holcomb-McCoy, Cheryl

    2004-01-01

    The author examines the concept of alienation and how it can be used to understand low-income, urban clients. A description is presented of 4 dimensions of alienation: powerlessness, meaninglessness, normlessness, and social isolation. Case illustrations are provided, and recommendations are made for counseling alienated clients. This article…

  4. Analyzing trigger levels for future test ban treaties

    SciTech Connect

    Miller, A.C. )

    1989-11-01

    Future test ban treaties may include the idea of triggers: test yields above which the country conducting a test must give the other side prior notice. The treaty would then allow the other side to inspect the test site or install additional yield measurement devices (e.g., CORRTEX). Triggers should help both sides verify treaty compliance when they conduct tests near the treaty threshold, a yield above which both sides are prohibited from testing. By using more accurate measurement systems at yields near the threshold, the country verifying compliance can decrease its uncertainty about the test yield. We can model the effect of triggers at various levels similar to the levels of analysis considered in the compliance evaluation report ( Decision Framework for Evaluating Compliance with the Threshold Test Ban Treaty'' by B.R. Judd, L.W. Younker, W.J. Hannon, R.S. Strait, P.C. Meagher, and A. Sicherman, UCRL-53830, August 1988). At lower levels, the analysis is simple but does not include all the issues relevant to choosing a trigger level. Higher levels of the analysis incorporate these issues, at the cost of additional complexity and required data. This memorandum considers several models of trigger levels to show what we can learn by incorporating additional issues into the analysis. 60 figs.

  5. The Majority of HIV Type 1 DNA in Circulating CD4+ T Lymphocytes Is Present in Non-Gut-Homing Resting Memory CD4+ T Cells

    PubMed Central

    Xu, Yin; Bailey, Michelle; Seddiki, Nabila; Suzuki, Kazuo; Murray, John M.; Gao, Yuan; Yan, Celine; Cooper, David A.; Kelleher, Anthony D.; Koelsch, Kersten K.; Zaunders, John

    2013-01-01

    Abstract Memory CD4+ T lymphocytes in peripheral blood that express integrins α4ß7 preferentially recirculate through gut-associated lymphoid tissue (GALT), a proposed site of significant HIV-1 replication. Tregs and activated CD4+ T cells in GALT could also be particularly susceptible to infection. We therefore hypothesized that infection of these subsets of memory CD4+ T cells may contribute disproportionately to the HIV-1 reservoir. A cross-sectional study of CD4+ T cell subsets of memory CD45RO+ cells in peripheral blood mononuclear cells (PBMCs) was conducted using leukapheresis from eight subjects with untreated chronic HIV-1 infection. Real-time polymerase chain reaction (PCR) was used to quantify total and integrated HIV-1 DNA levels from memory CD4+ T cells sorted into integrin β7+ vs. β7−, CD25+CD127low Treg vs. CD127high, and activated CD38+ vs. CD38−. More than 80% of total HIV-1 DNA was found to reside in the integrin β7-negative non-gut-homing subset of CD45RO+ memory CD4+ T cells. Less than 10% was found in highly purified Tregs or CD38+ activated memory cells. Similarly, integrated HIV-1 DNA copies were found to be more abundant in resting non-gut-homing memory CD4+ T cells (76%) than in their activated counterparts (23%). Our investigations showed that the majority of both total and integrated HIV-1 DNA was found within non-gut-homing resting CD4+ T cells. PMID:23971972

  6. Clinton advocates for Law of the Sea treaty

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    The Obama administration recently reiterated its call for the United States to ratify the United Nations Convention on the Law of the Sea. U.S. secretary of state Hillary Clinton, who expressed strong support for the Law of the Sea treaty during her Senate confirmation hearing in 2009, again called for passage of the treaty during 15 December remarks at a business roundtable in Washington, D. C., sponsored by the Pew Charitable Trusts. "Signing on to the convention is critical to protecting American security and enhancing our economic strength," she said, noting that the U.S. ratification of the treaty would protect American business interests by providing "legal certainty and predictability that businesses can rely on." The treaty—which also touches on a wide range of other issues including navigation, conservation and management of resources, and scientific research—is opposed by some who are concerned about the undermining of national sovereignty.

  7. Capability to Monitor the Comprehensive Nuclear-Test-Ban Treaty

    NASA Astrophysics Data System (ADS)

    2008-01-01

    In September 1996, the United States was the first country to sign the Comprehensive Nuclear-Test-Ban Treaty (CTBT), an international agreement to ban all nuclear test explosions, now signed by 177 nations. The treaty is intended to impede the development of nuclear weapons as part of the international nonproliferation regime. The treaty is not yet in effect because it has not been ratified by enough countries-including the United States. As a result, many of its verification provisions have not yet been fully implemented. When implemented, the American Geophysical Union (AGU) and the Seismological Society of America (SSA) are confident that the combined worldwide monitoring resources will meet the verification goals of the CTBT.

  8. Challenge inspections in Arms Control treaties: Any lessons for strengthening NPT verification. [Non-Proliferation Treaty (NPT)

    SciTech Connect

    Allentuck, J.

    1992-01-01

    Recent revelations of an ongoing and sophisticated nuclear weapons development program in Iraq have lead to suggestions for strengthening International Atomic Energy Agency (IAEA) safeguards. Especially troubling was the realization that safeguards, as presently applied, could not possibly have detected such a program. It is clear that the inspections which have taken place in Iraq since the Gulf War could only have been imposed on a nation which had suffered a severe military defeat. It has, however, been argued that challenge or challenge like'' inspections already incorporated in or proposed for the Treaty on Conventional Armed Forces in Europe (the CFE Treaty) the Chemical Weapons Convention (CWC) and the Treaty Between the United States and the USSR on the Reduction and Limitation of Strategic offensive Arms (START) might serve as models for enhanced special inspections in the Treaty on the Non-Proliferation of Nuclear Weapons (the NPT). The expectation that none of the challenge or challenge like inspections in the above treaties would provide a model for the NPT was confirmed although certain characteristics of these inspections do provide useful points of departure. Although the context of challenge inspections in CWC bears substantial similarity to the NPT, it is from the provisions for suspect-site'' and formerly declared site'', challenge like inspections in START that innovative ideas for strengthening special inspections in NPT may be derived.

  9. Bystander CD4+ T lymphocytes survive in HIV-infected human lymphoid tissue

    NASA Technical Reports Server (NTRS)

    Grivel, Jean-Charles; Biancotto, Angelique; Ito, Yoshinori; Lima, Rosangela G.; Margolis, Leonid B.

    2003-01-01

    HIV infection is associated with depletion of CD4(+) T cells. The mechanisms of this phenomenon remain to be understood. In particular, it remains controversial whether and to what extent uninfected ("bystander") CD4(+) T cells die in HIV-infected individuals. We address this question using a system of human lymphoid tissue ex vivo. Tissue blocks were inoculated with HIV-1. After productive infection was established, they were treated with the reverse transcriptase inhibitor nevirapine to protect from infection those CD4(+) T cells that had not yet been infected. These CD4(+) T cells residing in HIV-infected tissue are by definition bystanders. Our results demonstrate that after nevirapine application the number of bystander CD4(+) T cells is conserved. Thus, in the context of HIV-infected human lymphoid tissue, productive HIV infection kills infected cells but is not sufficient to cause the death of a significant number of uninfected CD4(+) T cells.

  10. Vaccine-Elicited CD4 T Cells Induce Immunopathology Following Chronic LCMV Infection

    PubMed Central

    Penaloza-MacMaster, Pablo; Barber, Daniel L.; Wherry, E. John; Provine, Nicholas M.; Teigler, Jeffrey E.; Parenteau, Lily; Blackmore, Stephen; Borducchi, Erica N.; Larocca, Rafael A.; Yates, Kathleen B.; Shen, Hao; Haining, W. Nicholas; Sommerstein, Rami; Pinschewer, Daniel D.; Ahmed, Rafi; Barouch, Dan. H.

    2015-01-01

    CD4 T cells promote innate and adaptive immune responses, but how vaccine-elicited CD4 T cells contribute to immune protection remains unclear. Here we evaluated whether induction of virus-specific CD4 T cells by vaccination would protect mice against infection with chronic lymphocytic choriomeningitis virus (LCMV). Immunization with vaccines that selectively induced CD4 T cell responses resulted in catastrophic inflammation and mortality following challenge with a persistent strain of LCMV. Immunopathology required antigen-specific CD4 T cells and was associated with a cytokine storm, generalized inflammation, and multi-organ system failure. Virus-specific CD8 T cells or antibodies abrogated the pathology. These data demonstrate that vaccine-elicited CD4 T cells in the absence of effective antiviral immune responses can trigger lethal immunopathology. PMID:25593185

  11. Index of Alien Impact: A Method for Evaluating Potential Ecological Impact of Alien Plant Species

    NASA Astrophysics Data System (ADS)

    Magee, Teresa K.; Ringold, Paul L.; Bollman, Michael A.; Ernst, Ted L.

    2010-04-01

    Alien plant species are stressors to ecosystems and indicators of reduced ecosystem integrity. The magnitude of the stress reflects not only the quantity of aliens present, but also the quality of their interactions with native ecosystems. We develop an Index of Alien Impact ( IAI) to estimate the collective ecological impact of in situ alien species. IAI summarizes the frequency of occurrence and potential ecological impact ( Invasiveness-Impact Score ( I i )) of individual alien species for all aliens present in a particular location or community type. A component metric, I i , is based on ecological species traits (life history, ecological amplitude, and ability to alter ecosystem processes) that reflect mechanisms, which can increase impact to ecosystem structure and function. While I i is less complex than some other multi-metric rankings of alien impact, it compares well to these metrics and to qualitative judgments. IAI can be adapted for different ecological settings by modifying the set of species traits incorporated in I i to reflect properties likely to breach biotic and abiotic barriers or alter ecosystem function in a particular region or community type of interest. To demonstrate our approach, we created versions of IAI and I i , applicable to the diverse streamside vegetation of a river basin (19,631 km2) spanning low-elevation arid to mesic montane habitats in eastern Oregon, USA. In this demonstration effort, we (1) evaluate relationships of IAI to metrics describing invasion level, and (2) illustrate the potential utility of IAI for prioritizing alien species management activities and informing restoration goals.

  12. US arms control obligations under the Non-Proliferation Treaty

    SciTech Connect

    Not Available

    1986-06-27

    Article VI of the 1968 Non-Proliferation Treaty (NPT) obligates the nuclear weapon states parties to the Treaty ''to pursue negotiations in good faith on effective measures relating to cessation of the nuclear arms race, ... to nuclear disarmament, and on a treaty on general and complete disarmament under strict and effective international control.'' The preamble to the NPT recalls the 1963 Limited Test Ban Treaty ''determination ... to achieve the discontinuance of ... explosions.'' These provisions are interpreted by a majority of the non-nuclear weapon states parties to the Treaty as an obligation of the nuclear weapon states parties to the Treaty to pursue a comprehensive test ban (CTB). However, a review of the history of the NPT negotiations and US ratification proceedings makes clear that the NPT imposes no legal obligation on the US to pursue a CTB. The US did not make a one-to-one correspondence between Article VI and any specific arms control measure; to the contrary, the US argued successfully that such a connection (to any specific measure) would be pernicious to the attempt to achieve agreement on the NPT. This interpretation, which was sustained through the negotiations and the ratification proceedings, still reflects the limits of the legal obligations the US has accepted. But, in the absence of progress on other arms control measures, which would relieve the pressure for a CTB, the majority interpretation creates political difficulties for the US and could threaten the NPT regime in the future. These problems highlight the need for the US to better defend its compliance with Article VI and to develop a long-term strategy that will permit necessary testing while assuring the survival of the NPT regime in effective form.

  13. The Lonely Consumer: Advertising and Alienation.

    ERIC Educational Resources Information Center

    Larson, Charles U.; Denton, Robert E.

    Advertising plays on the broad feelings of alienation (defined as an individual's frustrated or estranged responses to economic and sociological phenomena which affect that individual's place in society) which are endemic to the American consumer society and are, in Marxist views, symptomatic of any capitalist system. By generating anxieties and…

  14. Pathophysiology and Treatment of Alien Hand Syndrome

    PubMed Central

    Sarva, Harini; Deik, Andres; Severt, William Lawrence

    2014-01-01

    Background Alien hand syndrome (AHS) is a disorder of involuntary, yet purposeful, hand movements that may be accompanied by agnosia, aphasia, weakness, or sensory loss. We herein review the most reported cases, current understanding of the pathophysiology, and treatments. Methods We performed a PubMed search in July of 2014 using the phrases “alien hand syndrome,” “alien hand syndrome pathophysiology,” “alien hand syndrome treatment,” and “anarchic hand syndrome.” The search yielded 141 papers (reviews, case reports, case series, and clinical studies), of which we reviewed 109. Non-English reports without English abstracts were excluded. Results Accumulating evidence indicates that there are three AHS variants: frontal, callosal, and posterior. Patients may demonstrate symptoms of multiple types; there is a lack of correlation between phenomenology and neuroimaging findings. Most pathologic and functional imaging studies suggest network disruption causing loss of inhibition as the likely cause. Successful interventions include botulinum toxin injections, clonazepam, visuospatial coaching techniques, distracting the affected hand, and cognitive behavioral therapy. Discussion The available literature suggests that overlap between AHS subtypes is common. The evidence for effective treatments remains anecdotal, and, given the rarity of AHS, the possibility of performing randomized, placebo-controlled trials seems unlikely. As with many other interventions for movement disorders, identifying the specific functional impairments caused by AHS may provide the best guidance towards individualized supportive care. PMID:25506043

  15. Aliens Among Us : Are They Already Here ?

    NASA Astrophysics Data System (ADS)

    McGaha, J.

    2008-03-01

    Popular culture, science fiction and mainstream belief, says they are! What is the evidence? Astronomer, skeptic and retired USAF pilot James McGaha examines this "Space Age" Mythology. From years of investigation of the physical evidence of aliens and there spacecraft (UFO's) here on earth, McGaha presents the scientific facts.

  16. Processes of Alienation: Marx, Orff and Kodaly

    ERIC Educational Resources Information Center

    Benedict, Cathy

    2009-01-01

    Using Marx as a lens through which to interrogate music methodology, in particular those espoused by Orff and Kodaly, this article suggests that rather than the free play and creativity Orff and Kodaly intended, the implementation of these methods in a strict and unmindful manner, often alienates both teacher and student from musicking. Thus these…

  17. College as a Source of Black Alienation.

    ERIC Educational Resources Information Center

    Shingles, Richard D.

    1979-01-01

    This article summarizes college and precollege explanations of alienation and indicates how they intertwine in the case of Black college students. A multivariate analysis of Black students is then used to control for precollege experiences and isolate the independent impact of college life on Black students at a predominantly White university.…

  18. Student Drug Usage and Self-Alienation.

    ERIC Educational Resources Information Center

    Fischler, Michael L.

    Utilizing responses (a self administered, 15 item questionnaire) of a rural northeastern New England sample of junior high, senior high, and college students, correlation between legal and illegal drug use and perceived self-alienation was examined. Comparison was also made between users and nonusers. Legal users were defined as those who made at…

  19. The Alienating Influence of the Illusionogens

    ERIC Educational Resources Information Center

    Malcolm, Andrew I.

    1971-01-01

    The author, based on his discussion, hypothesizes that: (1) the use of marijuana may serve to intensify the tendency toward an adolescent's alienation and (2) attitudinal changes do occur in people who are exposed to the illusionogens and that these changes are more certainly fixed with continued use. (Author/BY)

  20. Invite an Alien to Astronomy Night

    ERIC Educational Resources Information Center

    Governor, Donna; Richwine, Pebble

    2007-01-01

    Dozens of inflatable aliens recently "descended" upon the authors' middle school to kick-off their first school-wide Astronomy night. With an estimated attendance of over 500, their eighth-grade students hosted over a dozen activity-rich sessions designed to entertain and educate students and their families about the wonders of the solar system…

  1. Creating Aliens: The Ultimate Life Sciences Activity.

    ERIC Educational Resources Information Center

    Beltramo, Dan

    2001-01-01

    Describes a seven-week project completed by the author's eighth-grade science students (as they studied "the chemistry of living things") in which they designed an alien and its world using the scientific concepts that they learned in class. Compares class presentations using PowerPoint software to presentations using posterboard. (SR)

  2. Combatives for Alienated Youth: Problems and Prospects.

    ERIC Educational Resources Information Center

    Hellison, Don

    Combative activities (boxing, wrestling, kung fu, etc.) are seen as having a positive influence on alienated inner city youth. Potential contributions of such activities in a school curriculum or recreation program include involvement, security, self-concept, and self-realization. Participants may be able to free themselves from such stereotype…

  3. 22 CFR 62.27 - Alien physicians.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... or academic medical center which has been designated an exchange visitor program by the Secretary of... Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES EXCHANGE VISITOR PROGRAM Specific Program Provisions § 62.27 Alien physicians. (a) Purpose. Pursuant to the Mutual Educational and Cultural...

  4. 22 CFR 62.27 - Alien physicians.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... or academic medical center which has been designated an exchange visitor program by the Secretary of... Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES EXCHANGE VISITOR PROGRAM Specific Program Provisions § 62.27 Alien physicians. (a) Purpose. Pursuant to the Mutual Educational and Cultural...

  5. TNF-α blockade induces IL-10 expression in human CD4+ T cells

    NASA Astrophysics Data System (ADS)

    Evans, Hayley G.; Roostalu, Urmas; Walter, Gina J.; Gullick, Nicola J.; Frederiksen, Klaus S.; Roberts, Ceri A.; Sumner, Jonathan; Baeten, Dominique L.; Gerwien, Jens G.; Cope, Andrew P.; Geissmann, Frederic; Kirkham, Bruce W.; Taams, Leonie S.

    2014-02-01

    IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory diseases. Here we demonstrate that TNF inhibitor (TNFi) drugs induce the anti-inflammatory cytokine IL-10 in CD4+ T cells including IL-17+ CD4+ T cells. TNFi-mediated induction of IL-10 in IL-17+ CD4+ T cells is Treg-/Foxp3-independent, requires IL-10 and is overcome by IL-1β. TNFi-exposed IL-17+ CD4+ T cells are molecularly and functionally distinct, with a unique gene signature characterized by expression of IL10 and IKZF3 (encoding Aiolos). We show that Aiolos binds conserved regions in the IL10 locus in IL-17+ CD4+ T cells. Furthermore, IKZF3 and IL10 expression levels correlate in primary CD4+ T cells and Aiolos overexpression is sufficient to drive IL10 in these cells. Our data demonstrate that TNF-α blockade induces IL-10 in CD4+ T cells including Th17 cells and suggest a role for the transcription factor Aiolos in the regulation of IL-10 in CD4+ T cells.

  6. ESTABLISHING MEAN CD4+ T CELL VALUES AMONG HEALTHY JAVANESE ADULTS IN INDONESIA.

    PubMed

    Prasetyo, Afiono Agung; Zaini, Khilyat Ulin Nur

    2015-07-01

    The objective of this study was to establish mean CD4+ T cell values among healthy Javanese adults in Indonesia. Two hundred forty-one healthy adults (119 women and 122 men), aged 18-65 years, were enrolled in the study. CD4+ T cells were analyzed by immunophenotyping. The mean absolute CD4+ T cell count was 753.3 ± 270.3 cells/µl (median = 725.0 cells/µl) and the mean CD4+ T cell percentage was 32.6 ± 7.7%, (median = 31.0%). Women had a slightly higher mean absolute CD4+ T cell count and CD4+ T cell percentage (779.1 ± 271.0 cells/ µl; 33.4 ± 8.2%) than men (728.2 ± 268.3 cells/µl; 31.8 ± 7.1%), but the differences were not statistically significant (p = 0.126, p = 0.216, respectively). The mean absolute CD4+ T cell varied significantly by age group (p = 0.002). Sixty-one point seven percent of men studied (37/60) had a CD4+ T cell count less than 500 cells/µl (OR 1.8; 95% CI = 1.001-3.300). Absolute CD4+ T cell counts among Javanese Indonesians varied significantly by age. PMID:26867386

  7. Proposal for revisions of the United Nations Moon Treaty

    NASA Astrophysics Data System (ADS)

    Fernandes, Vera; Abreu, Neyda; Fritz, J.; Knapmeyer, Martin; Smeenk, Lisa; Ten Kate, Inge; Trüninger, Monica

    During this new 2010-decade, it will be imperative to reconsider the effectiveness of the current United Nations (U.N.) Moon Treaty (c.1979). Amendments are necessary to underline the mandatory human stewardship of this fragile planetary body of our Solar System, indispensible to life on Earth. After the very successful Apollo and Luna missions to the Moon (ending in 1976), which brought a wide array of data (samples, surface and orbital experiments), the Moon lost its exploratory attraction in favor of other programs, such as the International Space Station and potential human exploration of Mars. However, since the mid-90's, the enthusiasm for the Moon has been revived, which resulted in several space agencies worldwide (NASA, ESA, ISRO, JAXA, and the Chinese Space Agency) having made great efforts to re-start ex-ploratory and scientific campaigns even though budgetary changes may delay the process. As a result, a wide array of peoples and their interests are put together in each mission planned to reach the Moon (e.g., orbiters and landers). Up to now, mission plans focus on technical requirements and the desires of scientists and engineers, but hardly any other aspects. Field specialists on issues regarding the social, economic, political, cultural, ethical and environmen-tal impacts of Moon exploration and colonization have had little to no involvement in current and past lunar missions. However, these fields would provide different and essential points of view regarding the planning of lunar missions. Moreover, recent documents written by the scientific community, such as "The Scientific Context for Exploration of the Moon: Final Re-port" Committee on the Scientific Context for Exploration of the Moon, National Research Council (2007), or the recent (summer 2009) White Papers for the National Research Council Planetary Science Decadal Survey 2011-2020, do not seem to leave space for a multidisciplinary approach regarding the future lunar exploration either

  8. The CD4(+) T cell methylome contributes to a distinct CD4(+) T cell transcriptional signature in Mycobacterium bovis-infected cattle.

    PubMed

    Doherty, Rachael; Whiston, Ronan; Cormican, Paul; Finlay, Emma K; Couldrey, Christine; Brady, Colm; O'Farrelly, Cliona; Meade, Kieran G

    2016-01-01

    We hypothesised that epigenetic regulation of CD4(+) T lymphocytes contributes to a shift toward a dysfunctional T cell phenotype which may impact on their ability to clear mycobacterial infection. Combined RNA-seq transcriptomic profiling and Reduced Representation Bisulfite Sequencing identified 193 significantly differentially expressed genes and 760 differentially methylated regions (DMRs), between CD4(+) T cells from M. bovis infected and healthy cattle. 196 DMRs were located within 10 kb of annotated genes, including GATA3 and RORC, both of which encode transcription factors that promote TH2 and TH17 T helper cell subsets respectively. Gene-specific DNA methylation and gene expression levels for the TNFRSF4 and Interferon-γ genes were significantly negatively correlated suggesting a regulatory relationship. Pathway analysis of DMRs identified enrichment of genes involved in the anti-proliferative TGF-β signaling pathway and TGFB1 expression was significantly increased in peripheral blood leukocytes from TB-infected cattle. This first analysis of the bovine CD4(+) T cell methylome suggests that DNA methylation directly contributes to a distinct gene expression signature in CD4(+) T cells from cattle infected with M. bovis. Specific methylation changes proximal to key inflammatory gene loci may be critical to the emergence of a non-protective CD4(+) T cell response during mycobacterial infection in cattle. PMID:27507428

  9. The CD4+ T cell methylome contributes to a distinct CD4+ T cell transcriptional signature in Mycobacterium bovis-infected cattle

    PubMed Central

    Doherty, Rachael; Whiston, Ronan; Cormican, Paul; Finlay, Emma K.; Couldrey, Christine; Brady, Colm; O’Farrelly, Cliona; Meade, Kieran G.

    2016-01-01

    We hypothesised that epigenetic regulation of CD4+ T lymphocytes contributes to a shift toward a dysfunctional T cell phenotype which may impact on their ability to clear mycobacterial infection. Combined RNA-seq transcriptomic profiling and Reduced Representation Bisulfite Sequencing identified 193 significantly differentially expressed genes and 760 differentially methylated regions (DMRs), between CD4+ T cells from M. bovis infected and healthy cattle. 196 DMRs were located within 10 kb of annotated genes, including GATA3 and RORC, both of which encode transcription factors that promote TH2 and TH17 T helper cell subsets respectively. Gene-specific DNA methylation and gene expression levels for the TNFRSF4 and Interferon-γ genes were significantly negatively correlated suggesting a regulatory relationship. Pathway analysis of DMRs identified enrichment of genes involved in the anti-proliferative TGF-β signaling pathway and TGFB1 expression was significantly increased in peripheral blood leukocytes from TB-infected cattle. This first analysis of the bovine CD4+ T cell methylome suggests that DNA methylation directly contributes to a distinct gene expression signature in CD4+ T cells from cattle infected with M. bovis. Specific methylation changes proximal to key inflammatory gene loci may be critical to the emergence of a non-protective CD4+ T cell response during mycobacterial infection in cattle. PMID:27507428

  10. 50 CFR 660.407 - Treaty Indian fishing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Treaty Indian fishing. 660.407 Section 660.407 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES West Coast Salmon...

  11. 50 CFR 660.407 - Treaty Indian fishing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Treaty Indian fishing. 660.407 Section 660.407 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES West Coast Salmon...

  12. 50 CFR 660.407 - Treaty Indian fishing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Treaty Indian fishing. 660.407 Section 660.407 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES West Coast Salmon...

  13. 50 CFR 660.407 - Treaty Indian fishing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Treaty Indian fishing. 660.407 Section 660.407 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES West Coast Salmon...

  14. 50 CFR 660.407 - Treaty Indian fishing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Treaty Indian fishing. 660.407 Section 660.407 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES West Coast Salmon...

  15. Taking aim at the ABM Treaty: THAAD and US Security

    SciTech Connect

    Pike, J.; Corbin, M.

    1995-05-01

    Successful testing of the Army`s Theater High Altitude Area Defense interceptor missile leads to speculation that the technology could render meaningless the Anti-Ballistic Missile (ABM) Treaty of 1972. The authors examine the ability of the political system to develop national strategies that incorporate the new realities created by technology.

  16. 50 CFR 660.50 - Pacific Coast treaty Indian fisheries.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... issued pursuant to 25 CFR part 249, subpart A, is prima facie evidence that the holder is a member of the... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Pacific Coast treaty Indian fisheries. 660.50 Section 660.50 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC...

  17. 50 CFR 660.50 - Pacific Coast treaty Indian fisheries.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... issued pursuant to 25 CFR part 249, subpart A, is prima facie evidence that the holder is a member of the... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Pacific Coast treaty Indian fisheries. 660.50 Section 660.50 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC...

  18. Researching Treaty Information: An Annotated Guide to Key Reference Sources.

    ERIC Educational Resources Information Center

    Miller, Gordon W.

    1985-01-01

    Designed for use with both individual researchers and library instruction classes, this 68-item selective annotated guide lists sources for guides and bibliographies; treatises, digests, citators; treaty texts and their indexes; dictionaries; atlases; style manuals; indexes and abstracts; journals; online databases; and abbreviations. Eleven…

  19. 37 CFR 1.401 - Definitions of terms under the Patent Cooperation Treaty.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Cooperation Treaty. (a) The abbreviation PCT and the term Treaty mean the Patent Cooperation Treaty. (b... referred to in PCT Rule 89. (d) Request, when capitalized, means that element of the international application described in PCT Rules 3 and 4. (e) International application, as used in this subchapter...

  20. The Lummi Indians and the Canadian/American Pacific Salmon Treaty.

    ERIC Educational Resources Information Center

    Boxberger, Daniel L.

    1988-01-01

    Explores the probable impact of the 1985 international Pacific Salmon Treaty on the Lummi tribe's catch of Fraser River salmon and economic well-being. Discusses the 1974 Boldt Decision, which allocated half of Washington State's salmon catch to treaty tribes, and contradictions in the federal government's conception of international treaties. (SV)

  1. 50 CFR 300.64 - Fishing by U.S. treaty Indian tribes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Ceremonial and subsistence fishing for halibut by treaty Indians in subarea 2A-1 is permitted with hook-and... member of a U.S. treaty Indian tribe who is engaged in commercial or ceremonial and subsistence fishing... pursuant to 25 CFR part 249, subpart A, and must comply with the treaty Indian vessel and...

  2. 75 FR 43198 - Agency Information Collection Activities: Comment Request for the Comprehensive Test Ban Treaty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... Test Ban Treaty (1 Form) AGENCY: U.S. Geological Survey (USGS), Interior. ACTION: Notice of an... requirements for the USGS Comprehensive Test Ban Treaty (CTBT). This collection consists of one form and this... OMB Control Number: 1028-0059. Form Number: 9-4040-A. Title: Comprehensive Test Ban Treaty. Type...

  3. The San Francisco Peace Treaty: The Cold War and the Peace Process.

    ERIC Educational Resources Information Center

    Brunette, Rachel

    International treaties have played a central role in diplomatic history since the rise of the modern nation state. Since the end of World War II, more treaties have been formed than in the preceding four centuries. The year 2001 marks the 50th anniversary of the San Francisco Peace Treaty. This unit provides students with historical knowledge of…

  4. 78 FR 75251 - Changes To Implement the Patent Law Treaty; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-11

    ... PLT. See Changes to Implement the Patent Law Treaty, 78 FR 62367 (Oct. 21, 2013). The PLT Final Rule... retains a cross- reference to 37 CFR 1.304. See Changes to Implement the Patent Law Treaty, 78 FR at 62382... Treaty, 78 FR at 62395. The PLT Final Rule as published in the Federal Register also amends 37 CFR...

  5. The Paradox of Sovereignty: Contingencies of Meaning in American Indian Treaty Discourse

    ERIC Educational Resources Information Center

    Russell, Caskey

    2008-01-01

    American Indian treaties and treaty law may seem to fall solely within the purview of legal methodology and critical analysis, yet the 367 American Indian treaties signed with the US federal government beg for the type of dissection and analysis generally associated with cultural and literary critical theory. The tools by which texts are dissected…

  6. Selective culling of high avidity antigen-specific CD4+ T cells after virulent Salmonella infection

    PubMed Central

    Ertelt, James M; Johanns, Tanner M; Mysz, Margaret A; Nanton, Minelva R; Rowe, Jared H; Aguilera, Marijo N; Way, Sing Sing

    2011-01-01

    Typhoid fever is a persistent infection caused by host-adapted Salmonella strains adept at circumventing immune-mediated host defences. Given the importance of T cells in protection, the culling of activated CD4+ T cells after primary infection has been proposed as a potential immune evasion strategy used by this pathogen. We demonstrate that the purging of activated antigen-specific CD4+ T cells after virulent Salmonella infection requires SPI-2 encoded virulence determinants, and is not restricted only to cells with specificity to Salmonella-expressed antigens, but extends to CD4+ T cells primed to expand by co-infection with recombinant Listeria monocytogenes. Unexpectedly, however, the loss of activated CD4+ T cells during Salmonella infection demonstrated using a monoclonal population of adoptively transferred CD4+ T cells was not reproduced among the endogenous repertoire of antigen-specific CD4+ T cells identified with MHC class II tetramer. Analysis of T-cell receptor variable segment usage revealed the selective loss and reciprocal enrichment of defined CD4+ T-cell subsets after Salmonella co-infection that is associated with the purging of antigen-specific cells with the highest intensity of tetramer staining. Hence, virulent Salmonella triggers the selective culling of high avidity activated CD4+ T-cell subsets, which re-shapes the repertoire of antigen-specific T cells that persist later after infection. PMID:22044420

  7. 26 CFR 1.6041-4T - Foreign-related items and other exceptions (temporary).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Foreign-related items and other exceptions (temporary). 1.6041-4T Section 1.6041-4T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... chapter 3 of the Internal Revenue Code (Code), under § 1.1461-1(b) and (c) and, for purposes of chapter...

  8. 26 CFR 1.7874-4T - Disregard of certain stock related to the acquisition (temporary).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Disregard of certain stock related to the acquisition (temporary). 1.7874-4T Section 1.7874-4T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) General Actuarial...

  9. Polyfunctional CD4 T cells in the response to bovine tuberculosis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    CD4 T cells are crucial in immunity to tuberculosis (TB). Polyfunctional CD4 T cells simultaneously produce interferon-gamma (IFN-gamma), Interleukin-2 (IL-2) and Tumor necrosis factor-alpha (TNF-alpha) and play relevant roles in several chronic infections, including human TB and HIV. However, the a...

  10. Polyfunctional cytokine responses by central memory CD4+T cells in response to bovine tuberculosis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    CD4 T cells are crucial in immunity to tuberculosis (TB). Polyfunctional CD4 T cells simultaneously produce interferon-gamma (IFN-gamma), interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) and play relevant roles in several chronic infections, including human TB and HIV. Mycobacterium ...

  11. Polyfunctional cytokine responses by central memory CD4*T cells in response to bovine tuberculosis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    CD4 T cells are crucial in immunity to tuberculosis (TB). Polyfunctional CD4 T cells simultaneously produce interferon-gamma (IFN-gamma), interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) and play relevant roles in several chronic infections, including human TB. Mycobacterium bovis in...

  12. Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.

    PubMed

    Delong, Thomas; Wiles, Timothy A; Baker, Rocky L; Bradley, Brenda; Barbour, Gene; Reisdorph, Richard; Armstrong, Michael; Powell, Roger L; Reisdorph, Nichole; Kumar, Nitesh; Elso, Colleen M; DeNicola, Megan; Bottino, Rita; Powers, Alvin C; Harlan, David M; Kent, Sally C; Mannering, Stuart I; Haskins, Kathryn

    2016-02-12

    T cell-mediated destruction of insulin-producing β cells in the pancreas causes type 1 diabetes (T1D). CD4 T cell responses play a central role in β cell destruction, but the identity of the epitopes recognized by pathogenic CD4 T cells remains unknown. We found that diabetes-inducing CD4 T cell clones isolated from nonobese diabetic mice recognize epitopes formed by covalent cross-linking of proinsulin peptides to other peptides present in β cell secretory granules. These hybrid insulin peptides (HIPs) are antigenic for CD4 T cells and can be detected by mass spectrometry in β cells. CD4 T cells from the residual pancreatic islets of two organ donors who had T1D also recognize HIPs. Autoreactive T cells targeting hybrid peptides may explain how immune tolerance is broken in T1D. PMID:26912858

  13. Development and Function of Protective and Pathologic Memory CD4 T Cells

    PubMed Central

    Jaigirdar, Shafqat Ahrar; MacLeod, Megan K. L.

    2015-01-01

    Immunological memory is one of the defining features of the adaptive immune system. As key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of adaptive immune responses. Generated following an immune response, memory CD4 T cells retain pertinent information about their activation environment enabling them to make rapid effector responses upon reactivation. These responses can either benefit the host by hastening the control of pathogens or cause damaging immunopathology. Here, we will discuss the diversity of the memory CD4 T cell pool, the signals that influence the transition of activated T cells into that pool, and highlight how activation requirements differ between naïve and memory CD4 T cells. A greater understanding of these factors has the potential to aid the design of more effective vaccines and to improve regulation of pathologic CD4 T cells, such as in the context of autoimmunity and allergy. PMID:26441961

  14. Dissecting How CD4 T Cells Are Lost During HIV Infection.

    PubMed

    Doitsh, Gilad; Greene, Warner C

    2016-03-01

    Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail, less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is this cell death process that drives clinical progression to acquired immune deficiency syndrome (AIDS). Recent studies have highlighted how abortive infection of resting and thus nonpermissive CD4 T cells in lymphoid tissues triggers a lethal innate immune response against the incomplete DNA products generated by inefficient viral reverse transcription in these cells. Sensing of these DNA fragments results in pyroptosis, a highly inflammatory form of programmed cell death, that potentially further perpetuates chronic inflammation and immune activation. As discussed here, these studies cast CD4 T cell death during HIV infection in a different light. Further, they identify drug targets that may be exploited to both block CD4 T cell demise and the chronic inflammatory response generated during pyroptosis. PMID:26962940

  15. The Interplay Between Monocytes/Macrophages and CD4+ T Cell Subsets in Rheumatoid Arthritis

    PubMed Central

    Roberts, Ceri A.; Dickinson, Abigail K.; Taams, Leonie S.

    2015-01-01

    Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovial lining (synovitis). The inflammation in the RA joint is associated with and driven by immune cell infiltration, synovial hyperproliferation, and excessive production of proinflammatory mediators, such as tumor necrosis factor α (TNFα), interferon γ (IFNγ), interleukin (IL)-1β, IL-6, and IL-17, eventually resulting in damage to the cartilage and underlying bone. The RA joint harbors a wide range of immune cell types, including monocytes, macrophages, and CD4+ T cells (both proinflammatory and regulatory). The interplay between CD14+ myeloid cells and CD4+ T cells can significantly influence CD4+ T cell function, and conversely, effector vs. regulatory CD4+ T cell subsets can exert profound effects on monocyte/macrophage function. In this review, we will discuss how the interplay between CD4+ T cells and monocytes/macrophages may contribute to the immunopathology of RA. PMID:26635790

  16. CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals.

    PubMed

    Arnold, Kelly B; Szeto, Gregory L; Alter, Galit; Irvine, Darrell J; Lauffenburger, Douglas A

    2015-10-20

    A vital defect in the immune systems of HIV-infected individuals is the loss of CD4(+) T cells, resulting in impaired immune responses. We hypothesized that there were CD4(+) T cell-dependent and CD4(+) T cell-independent alterations in the immune responses of HIV-1(+) individuals. To test this, we analyzed the secretion of cytokines and chemokines from stimulated peripheral blood mononuclear cell (PBMC) populations from HIV(+) donors, healthy donors, and healthy donors with CD4(+) T cells experimentally depleted. Multivariate analyses of 16 cytokines and chemokines at 6 and 72 hours after three stimuli (antibody-coated beads to stimulate T cells and R848 or lipopolysaccharide to stimulate innate immune cells) enabled integrative analysis of secreted profiles. Two major effects in HIV(+) PBMCs were not reproduced upon depletion of CD4(+) T cells in healthy PBMCs: (i) HIV(+) PBMCs maintained T cell-associated secreted profiles after T cell stimulation; (ii) HIV(+) PBMCs showed impaired interferon-γ (IFN-γ) secretion early after innate stimulation. These changes arose from hyperactive T cells and debilitated natural killer (NK) cell, respectively. Modeling and experiments showed that early IFN-γ secretion predicted later differences in secreted profiles in vitro. This effect was recapitulated in healthy PBMCs by blocking the IFN-γ receptor. Thus, we identified a critical deficiency in NK cell responses of HIV-infected individuals, independent of CD4(+) T cell depletion, which directs secreted profiles. Our findings illustrate a broad approach for identifying key disease-associated nodes in a multicellular, multivariate signaling network. PMID:26486173

  17. Gut Mucosal FOXP3+ Regulatory CD4+ T Cells and Nonregulatory CD4+ T Cells Are Differentially Affected by Simian Immunodeficiency Virus Infection in Rhesus Macaques▿

    PubMed Central

    Allers, Kristina; Loddenkemper, Christoph; Hofmann, Jörg; Unbehaun, Anett; Kunkel, Désirée; Moos, Verena; Kaup, Franz-Josef; Stahl-Hennig, Christiane; Sauermann, Ulrike; Epple, Hans-Jörg; Schneider, Thomas

    2010-01-01

    The gastrointestinal tract represents a major site for human and simian immunodeficiency virus (HIV and SIV) replication and CD4+ T-cell depletion. Despite severe depletion of mucosal CD4+ T cells, FOXP3+ regulatory CD4+ T cells (Treg) are highly increased in the gut mucosa of chronically HIV-infected individuals and may contribute to HIV pathogenesis, either by their immunosuppressive function or as a significant target cell population for virus production. Little is known about the susceptibility of mucosal Treg to viral infection and the longitudinal effect of HIV/SIV infection on Treg dynamics. In this study, we determined the level of SIV infection in Treg and nonregulatory CD4+ T cells (non-Treg) isolated from the colon of SIV-infected rhesus macaques. The dynamics of mucosal Treg and alterations in the mucosal CD4+ T-cell pool were examined longitudinally. Our findings indicate that mucosal Treg were less susceptible to productive SIV infection than non-Treg and thus were selectively spared from SIV-mediated cell death. In addition to improved survival, local expansion of Treg by SIV-induced proliferation of the mucosal CD4+ T-cell pool facilitated the accumulation of mucosal Treg during the course of infection. High frequency of mucosal Treg in chronic SIV infection was strongly related to a reduction of perforin-expressing cells. In conclusion, this study suggests that mucosal Treg are less affected by productive SIV infection than non-Treg and therefore spared from depletion. Although SIV production is limited in mucosal Treg, Treg accumulation may indirectly contribute to viral persistence by suppressing antiviral immune responses. PMID:20071575

  18. 8 CFR 241.21 - Stay of deportation of excluded alien.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Stay of deportation of excluded alien. 241.21 Section 241.21 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF ALIENS ORDERED REMOVED Deportation of Excluded Aliens (for Hearings...

  19. 8 CFR 241.24 - Notice to transportation line of alien's exclusion.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Notice to transportation line of alien's exclusion. 241.24 Section 241.24 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF ALIENS ORDERED REMOVED Deportation of Excluded Aliens (for...

  20. 8 CFR 241.21 - Stay of deportation of excluded alien.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Stay of deportation of excluded alien. 241.21 Section 241.21 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF ALIENS ORDERED REMOVED Deportation of Excluded Aliens (for Hearings...

  1. 8 CFR 241.21 - Stay of deportation of excluded alien.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Stay of deportation of excluded alien. 241.21 Section 241.21 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF ALIENS ORDERED REMOVED Deportation of Excluded Aliens (for Hearings...

  2. 8 CFR 241.21 - Stay of deportation of excluded alien.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Stay of deportation of excluded alien. 241.21 Section 241.21 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF ALIENS ORDERED REMOVED Deportation of Excluded Aliens (for Hearings...

  3. 8 CFR 241.21 - Stay of deportation of excluded alien.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Stay of deportation of excluded alien. 241.21 Section 241.21 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF ALIENS ORDERED REMOVED Deportation of Excluded Aliens (for Hearings...

  4. 45 CFR 1626.4 - Aliens eligible for assistance under anti-abuse laws.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Aliens eligible for assistance under anti-abuse... SERVICES CORPORATION RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.4 Aliens eligible for assistance... alien who is within one of the following categories: (i) An alien who has been battered or subjected...

  5. Eomesodermin Expression in CD4+ T Cells Restricts Peripheral Foxp3 Induction.

    PubMed

    Lupar, Ekaterina; Brack, Maria; Garnier, Laure; Laffont, Sophie; Rauch, Katharina S; Schachtrup, Kristina; Arnold, Sebastian J; Guéry, Jean-Charles; Izcue, Ana

    2015-11-15

    CD4(+) T cells polarize into effector Th subsets characterized by signature transcription factors and cytokines. Although T-bet drives Th1 responses and represses the alternative Th2, Th17, and Foxp3(+) regulatory T cell fates, the role of the T-bet-related transcription factor eomesodermin (Eomes) in CD4(+) T cells is less well understood. In this study, we analyze the expression and effects of Eomes in mouse CD4(+) T lymphocytes. We find that Eomes is readily expressed in activated CD4(+) Th1 T cells in vivo. Eomes(+) CD4(+) T cells accumulated in old mice, under lymphopenic conditions in a T cell transfer model of colitis, and upon oral Ag administration. However, despite its expression, genetic deletion of Eomes in CD4(+) T cells did not impact on IFN-γ production nor increase Th2 or Th17 responses. In contrast, Eomes deficiency favored the accumulation of Foxp3(+) cells in old mice, after in vivo differentiation of Eomes-deficient naive CD4(+) T cells, and in response to oral Ag in a cell-intrinsic way. Enforced Eomes expression during in vitro regulatory T cell induction also reduced Foxp3 transcription. Likewise, bystander Eomes-deficient CD4(+) T cells were more efficient at protecting from experimental autoimmune encephalitis compared with wild-type CD4(+) T cells. This enhanced capacity of Eomes-deficient CD4(+) T cells to inhibit EAE in trans was associated with an enhanced frequency of Foxp3(+) cells. Our data identify a novel role for Eomes in CD4(+) T cells and indicate that Eomes expression may act by limiting Foxp3 induction, which may contribute to the association of EOMES to susceptibility to multiple sclerosis. PMID:26453746

  6. Autoimmunity vs. cancer: predator vs. alien?

    PubMed

    Berens, Christian; Lauber, Kirsten; Herrmann, Martin

    2013-08-01

    "The enemy of my enemy is my friend." According to this motto, the human protagonists in Paul W. S. Anderson's science-fiction movie "Alien vs. Predator" (2004) solidarize with a predator in order to fight the aliens. Can this ancient and simple logic be transferred to the field of oncology and cancer immunotherapy? Can we utilize mechanisms known from the context of autoimmunity to fight cancer? Here, we summarize immune cell-mediated detection of danger and damage, central and peripheral tolerance, immunoregulation and immune privilege--processes known to be deregulated in the context of autoimmunity. We discuss them with special regard towards their misusage by tumors and pathogens and how they might be instrumentalized in the context of anti-cancer immunotherapy. PMID:23706137

  7. Evolutionary objections to "alien design" models.

    NASA Astrophysics Data System (ADS)

    Coffey, E. J.

    A previous paper demonstrated that the principal supporters of SETI have ignored the biological and evolutionary consequences of a creature's body form. In fact, the supporting evidence they provide actually contradicts their view. The approach they employ is that of the engineer: the process of "designing" a hypothetical creature to a specification irrespective of biological or evolutionary considerations. The principal types of "alien designs" which have been employed shall be discussed, and the evolutionary objections to them given.

  8. SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

    PubMed Central

    Baldauf, Hanna-Mari; Pan, Xiaoyu; Erikson, Elina; Schmidt, Sarah; Daddacha, Waaqo; Burggraf, Manja; Schenkova, Kristina; Ambiel, Ina; Wabnitz, Guido; Gramberg, Thomas; Panitz, Sylvia; Flory, Egbert; Landau, Nathaniel R; Sertel, Serkan; Rutsch, Frank; Lasitschka, Felix; Kim, Baek; König, Renate; Fackler, Oliver T; Keppler, Oliver T

    2013-01-01

    Unlike activated CD4+ T cells, resting CD4+ T cells are highly resistant to productive HIV-1 infection1–8. Early after HIV-1 entry, a major block limits reverse transcription of incoming viral genomes. Here we show that the deoxynucleoside triphosphate triphosphohydrolase SAMHD1 prevents reverse transcription of HIV-1 RNA in resting CD4+ T cells. SAMHD1 is abundantly expressed in resting CD4+ T cells circulating in peripheral blood and residing in lymphoid organs. The early restriction to infection in unstimulated CD4+ T cells is overcome by HIV-1 or HIV-2 virions into which viral Vpx is artificially or naturally packaged, respectively, or by addition of exogenous deoxynucleosides. Vpx-mediated proteasomal degradation of SAMHD1 and elevation of intracellular deoxynucleotide pools precede successful infection by Vpx-carrying HIV. Resting CD4+ T cells from healthy donors following SAMHD1 silencing or from a patient with Aicardi-Goutières syndrome homozygous for a nonsense mutation in SAMHD1 were permissive for HIV-1 infection. Thus, SAMHD1 imposes an effective restriction to HIV-1 infection in the large pool of noncycling CD4+ T cells in vivo. Bypassing SAMHD1 was insufficient for the release of viral progeny, implicating other barriers at later stages of HIV replication. Together, these findings may unveil new ways to interfere with the immune evasion and T cell immunopathology of pandemic HIV-1. PMID:22972397

  9. Itk Signals Promote Neuroinflammation by Regulating CD4+ T-Cell Activation and Trafficking

    PubMed Central

    Kannan, Arun K.; Kim, Do-Geun

    2015-01-01

    Here we demonstrate that interleukin-2-inducible T-cell kinase (Itk) signaling in cluster of differentiation 4-positive (CD4+) T cells promotes experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). We show that Itk−/− mice exhibit reduced disease severity, and transfer of Itk−/− CD4+ T cells into T cell-deficient recipients results in lower disease severity. We observed a significant reduction of CD4+ T cells in the CNS of Itk−/− mice or recipients of Itk−/− CD4+ T cells during EAE, which is consistent with attenuated disease. Itk−/− CD4+ T cells exhibit defective response to myelin antigen stimulation attributable to displacement of filamentous actin from the CD4+ coreceptor. This results in inadequate transmigration of Itk−/− CD4+ T cells into the CNS and across brain endothelial barriers in vitro. Finally, Itk−/− CD4+ T cells show significant reduction in production of T-helper 1 (Th1) and Th17 cytokines and exhibit skewed T effector/T regulatory cell ratios. These results indicate that signaling by Itk promotes autoimmunity and CNS inflammation, suggesting that it may be a viable target for treatment of MS. PMID:25568116

  10. Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces CD4+ T Cell Anergy via GRAIL.

    PubMed

    Sande, Obondo J; Karim, Ahmad F; Li, Qing; Ding, Xuedong; Harding, Clifford V; Rojas, Roxana E; Boom, W Henry

    2016-01-15

    Mycobacterium tuberculosis cell wall glycolipid, lipoarabinomannan, can inhibit CD4(+) T cell activation by downregulating the phosphorylation of key proximal TCR signaling molecules: Lck, CD3ζ, ZAP70, and LAT. Inhibition of proximal TCR signaling can result in T cell anergy, in which T cells are inactivated following an Ag encounter, yet remain viable and hyporesponsive. We tested whether mannose-capped lipoarabinomannan (LAM)-induced inhibition of CD4(+) T cell activation resulted in CD4(+) T cell anergy. The presence of LAM during primary stimulation of P25 TCR-transgenic murine CD4(+) T cells with M. tuberculosis Ag85B peptide resulted in decreased proliferation and IL-2 production. P25 TCR-transgenic CD4(+) T cells primed in the presence of LAM also exhibited decreased response upon restimulation with Ag85B. The T cell anergic state persisted after the removal of LAM. Hyporesponsiveness to restimulation was not due to apoptosis, generation of Foxp3-positive regulatory T cells, or inhibitory cytokines. Acquisition of the anergic phenotype correlated with upregulation of gene related to anergy in lymphocytes (GRAIL) protein in CD4(+) T cells. Inhibition of human CD4(+) T cell activation by LAM also was associated with increased GRAIL expression. Small interfering RNA-mediated knockdown of GRAIL before LAM treatment abrogated LAM-induced hyporesponsiveness. In addition, exogenous IL-2 reversed defective proliferation by downregulating GRAIL expression. These results demonstrate that LAM upregulates GRAIL to induce anergy in Ag-reactive CD4(+) T cells. Induction of CD4(+) T cell anergy by LAM may represent one mechanism by which M. tuberculosis evades T cell recognition. PMID:26667170

  11. Hydrogen peroxide-dependent 4-t-butylphenol hydroxylation by tyrosinase--a new catalytic activity.

    PubMed

    Jiménez, M; García-Carmona, F

    1996-09-13

    The aim of this work was to study the hydroxylation by tyrosinase of 4-t-butylphenol to 4-t-butylcatechol, in the presence of hydrogen peroxide. This hydroxylation reaction does not take place without the addition of hydrogen peroxide. Some properties of this new hydroxylating activity have been analysed. The kinetic parameters of mushroom tyrosinase for hydrogen peroxide (K(m) = 4.9 mM, V(m) = 48.1 microM/min) and 4-t-butylphenol (K(m) = 16 microM/min, V(m) = 6.7 microM/min) were evaluated. A lag period appeared, which was similar to the characteristic lag of monophenolase activity at the expense of molecular oxygen. The length of the lag phase decreased with increasing hydrogen peroxide concentrations but was longer with higher 4-t-butylphenol concentrations. The pH optimum for this hydroxylating activity was close to 5.5. The lag also varied with pH, reaching its highest value at pH 4.8. The lag was shortened by the addition of increasing amounts of 4-t-butylcatechol, and was abolished at 24.5 microM of 4-t-butylcatechol. 4-t-Butylphenol was oxidized by mushroom tyrosinase in the presence of 24.5 microM 4-t-butylcatechol and in the absence of hydrogen peroxide although the enzymatic activity tailed off. The presence of hydrogen peroxide is necessary to maintain a constant steady-state rate of 4-t-butylphenol oxidation by tyrosinase. PMID:8841378

  12. Alien species as a driver of recent extinctions.

    PubMed

    Bellard, Céline; Cassey, Phillip; Blackburn, Tim M

    2016-02-01

    We assessed the prevalence of alien species as a driver of recent extinctions in five major taxa (plants, amphibians, reptiles, birds and mammals), using data from the IUCN Red List. Our results show that alien species are the second most common threat associated with species that have gone completely extinct from these taxa since AD 1500. Aliens are the most common threat associated with extinctions in three of the five taxa analysed, and for vertebrate extinctions overall. PMID:26888913

  13. The Nuclear Non-Proliferation Treaty and the Comprehensive Nuclear-Test-Ban Treaty, the relationship

    SciTech Connect

    Graham, Thomas Jr.

    2014-05-09

    The Nuclear Non-Proliferation Treaty (NPT) is the most important international security arrangement that we have that is protecting the world community and this has been true for many years. But it did not happen by accident, it is a strategic bargain in which 184 states gave up the right forever to acquire the most powerful weapon ever created in exchange for a commitment from the five states allowed to keep nuclear weapons under the NPT (U.S., U.K., Russia, France and China), to share peaceful nuclear technology and to engage in disarmament negotiations aimed at the ultimate elimination of their nuclear stockpiles. The most important part of this is the comprehensive nuclear test ban (CTBT); the thinking by the 184 NPT non-nuclear weapon states was and is that they understand that the elimination of nuclear weapon stockpiles is a long way off, but at least the NPT nuclear weapon states could stop testing the weapons. The CTBT has been ratified by 161 states but by its terms it can only come into force if 44 nuclear potential states ratify; 36 have of the 44 have ratified it, the remaining eight include the United States and seven others, most of whom are in effect waiting for the United States. No state has tested a nuclear weapon-except for complete outlier North Korea-in 15 years. There appears to be no chance that the U.S. Senate will approve the CTBT for ratification in the foreseeable future, but the NPT may not survive without it. Perhaps it is time to consider an interim measure, for the UN Security Council to declare that any future nuclear weapon test any time, anywhere is a 'threat to peace and security', in effect a violation of international law, which in today's world it clearly would be.

  14. The Nuclear Non-Proliferation Treaty and the Comprehensive Nuclear-Test-Ban Treaty, the relationship

    NASA Astrophysics Data System (ADS)

    Graham, Thomas, Jr.

    2014-05-01

    The Nuclear Non-Proliferation Treaty (NPT) is the most important international security arrangement that we have that is protecting the world community and this has been true for many years. But it did not happen by accident, it is a strategic bargain in which 184 states gave up the right forever to acquire the most powerful weapon ever created in exchange for a commitment from the five states allowed to keep nuclear weapons under the NPT (U.S., U.K., Russia, France and China), to share peaceful nuclear technology and to engage in disarmament negotiations aimed at the ultimate elimination of their nuclear stockpiles. The most important part of this is the comprehensive nuclear test ban (CTBT); the thinking by the 184 NPT non-nuclear weapon states was and is that they understand that the elimination of nuclear weapon stockpiles is a long way off, but at least the NPT nuclear weapon states could stop testing the weapons. The CTBT has been ratified by 161 states but by its terms it can only come into force if 44 nuclear potential states ratify; 36 have of the 44 have ratified it, the remaining eight include the United States and seven others, most of whom are in effect waiting for the United States. No state has tested a nuclear weapon-except for complete outlier North Korea-in 15 years. There appears to be no chance that the U.S. Senate will approve the CTBT for ratification in the foreseeable future, but the NPT may not survive without it. Perhaps it is time to consider an interim measure, for the UN Security Council to declare that any future nuclear weapon test any time, anywhere is a "threat to peace and security", in effect a violation of international law, which in today's world it clearly would be.

  15. Does ratification of human-rights treaties have effects on population health?

    PubMed

    Palmer, Alexis; Tomkinson, Jocelyn; Phung, Charlene; Ford, Nathan; Joffres, Michel; Fernandes, Kimberly A; Zeng, Leilei; Lima, Viviane; Montaner, Julio S G; Guyatt, Gordon H; Mills, Edward J

    2009-06-01

    Human-rights treaties indicate a country's commitment to human rights. Here, we assess whether ratification of human-rights treaties is associated with improved health and social indicators. Data for health (including HIV prevalence, and maternal, infant, and child [<5 years] mortalities) and social indicators (child labour, human development index, sex gap, and corruption index), gathered from 170 countries, showed no consistent associations between ratification of human-rights treaties and health or social outcomes. Established market economy states had consistently improved health compared with less wealthy settings, but this was not associated with treaty ratification. The status of treaty ratification alone is not a good indicator of the realisation of the right to health. We suggest the need for stringent requirements for ratification of treaties, improved accountability mechanisms to monitor compliance of states with treaty obligations, and financial assistance to support the realisation of the right to health. PMID:19501746

  16. Proposal for revisions of the United Nations Moon Treaty

    NASA Astrophysics Data System (ADS)

    Fernandes, Vera; Abreu, Neyda; Fritz, J.; Knapmeyer, Martin; Smeenk, Lisa; Ten Kate, Inge; Trüninger, Monica

    During this new 2010-decade, it will be imperative to reconsider the effectiveness of the current United Nations (U.N.) Moon Treaty (c.1979). Amendments are necessary to underline the mandatory human stewardship of this fragile planetary body of our Solar System, indispensible to life on Earth. After the very successful Apollo and Luna missions to the Moon (ending in 1976), which brought a wide array of data (samples, surface and orbital experiments), the Moon lost its exploratory attraction in favor of other programs, such as the International Space Station and potential human exploration of Mars. However, since the mid-90's, the enthusiasm for the Moon has been revived, which resulted in several space agencies worldwide (NASA, ESA, ISRO, JAXA, and the Chinese Space Agency) having made great efforts to re-start ex-ploratory and scientific campaigns even though budgetary changes may delay the process. As a result, a wide array of peoples and their interests are put together in each mission planned to reach the Moon (e.g., orbiters and landers). Up to now, mission plans focus on technical requirements and the desires of scientists and engineers, but hardly any other aspects. Field specialists on issues regarding the social, economic, political, cultural, ethical and environmen-tal impacts of Moon exploration and colonization have had little to no involvement in current and past lunar missions. However, these fields would provide different and essential points of view regarding the planning of lunar missions. Moreover, recent documents written by the scientific community, such as "The Scientific Context for Exploration of the Moon: Final Re-port" Committee on the Scientific Context for Exploration of the Moon, National Research Council (2007), or the recent (summer 2009) White Papers for the National Research Council Planetary Science Decadal Survey 2011-2020, do not seem to leave space for a multidisciplinary approach regarding the future lunar exploration either

  17. Scope and verification of a Fissile Material (Cutoff) Treaty

    SciTech Connect

    Hippel, Frank N. von

    2014-05-09

    A Fissile Material Cutoff Treaty (FMCT) would ban the production of fissile material - in practice highly-enriched uranium and separated plutonium - for weapons. It has been supported by strong majorities in the United Nations. After it comes into force, newly produced fissile materials could only be produced under international - most likely International Atomic Energy Agency - monitoring. Many non-weapon states argue that the treaty should also place under safeguards pre-existing stocks of fissile material in civilian use or declared excess for weapons so as to make nuclear-weapons reductions irreversible. This paper discusses the scope of the FMCT, the ability to detect clandestine production and verification challenges in the nuclear-weapons states.

  18. The Arms Trade Treaty (ATT): a public health imperative.

    PubMed

    Valenti, Maria; Mtonga, Robert; Gould, Robert; Christ, Michael

    2014-02-01

    The United Nations adopted an historic international Arms Trade Treaty (ATT) in April 2013. A 1997 meeting of Nobel Peace Prize laureates who called for an International Code of Conduct to address the 'destructive effects of the unregulated arms trade' initiated discussions that led to the Treaty. Public health institutions, including the World Health Organization and the International Committee of the Red Cross, and nongovernmental health groups such as International Physicians for the Prevention of Nuclear War, made adoption of the ATT a public health imperative. The poorly regulated $70 billion annual trade in conventional arms fuels conflict, with devastating effects on global health. The ATT aims to 'reduce human suffering'. It prohibits arms' sales if there is knowledge that the arms would be used in the commission of genocide, attacks against civilians, or war crimes. The health community has much to contribute to ensuring ratification and implementation of the ATT. PMID:24257633

  19. Scope and verification of a Fissile Material (Cutoff) Treaty

    NASA Astrophysics Data System (ADS)

    von Hippel, Frank N.

    2014-05-01

    A Fissile Material Cutoff Treaty (FMCT) would ban the production of fissile material - in practice highly-enriched uranium and separated plutonium - for weapons. It has been supported by strong majorities in the United Nations. After it comes into force, newly produced fissile materials could only be produced under international - most likely International Atomic Energy Agency - monitoring. Many non-weapon states argue that the treaty should also place under safeguards pre-existing stocks of fissile material in civilian use or declared excess for weapons so as to make nuclear-weapons reductions irreversible. This paper discusses the scope of the FMCT, the ability to detect clandestine production and verification challenges in the nuclear-weapons states.

  20. Human CD141+ DCs induce CD4+ T cells to produce type 2 cytokines1

    PubMed Central

    Yu, Chun I; Becker, Christian; Metang, Patrick; Marches, Florentina; Wang, Yuanyuan; Toshiyuki, Hori; Banchereau, Jacques; Merad, Miriam; Palucka, Karolina

    2014-01-01

    Dendritic cells (DCs) play the central role in the priming of naïve T cells and the differentiation of unique effector T cells. Here, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c+ and CD141+ DC subsets to live-attenuated influenza virus (LAIV). Specifically, we analyzed the type of CD4+ T cell immunity elicited by LAIV-exposed DCs. Both DC subsets induce proliferation of allogeneic naïve CD4+ T cells with capacity to secrete IFN-γ. However, CD141+ DCs are uniquely able to induce the differentiation of IL-4 and IL-13 producing CD4+ T cells. CD141+ DCs induce IL-4 and IL-13 secreting CD4+ T cells through OX40L. Thus, CD141+ DCs demonstrate remarkable plasticity in guiding adaptive immune responses. PMID:25246496

  1. Radiative recombination kinetics in electroluminescent spin cast pristine α-4T

    NASA Astrophysics Data System (ADS)

    Ben Hamed, Zied; Kouki, Fayçal; Bouchriha, Habib; Mejatty, Mohamed

    2016-09-01

    Many experimental studies have established the substantial impact of the sound structure of the organic thin films on optoelectronic device performances. This study is a collection of experimental and theoretical investigation of the radiative recombination kinetics in an organic light emitting diode based on spin cast α-4T. The structural properties of the organic thin films (α-4T) deposited by the spin coating technique are discussed. The electrical characterization of the diode-like samples (ITO/α-4T/Al) have revealed a very low effective mobility of charge carriers in the spin cast α-4Tand the radiative recombination current was extracted. The luminescence-current characterization of the diode-like samples (ITO/α-4T/Al) was investigated and modeled.

  2. Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation.

    PubMed

    Lawson, Brian R; Gonzalez-Quintial, Rosana; Eleftheriadis, Theodoros; Farrar, Michael A; Miller, Stephen D; Sauer, Karsten; McGavern, Dorian B; Kono, Dwight H; Baccala, Roberto; Theofilopoulos, Argyrios N

    2015-12-01

    IL-7 is known to be vital for T cell homeostasis but has previously been presumed to be dispensable for TCR-induced activation. Here, we show that IL-7 is critical for the initial activation of CD4(+) T cells in that it provides some of the necessary early signaling components, such as activated STAT5 and Akt. Accordingly, short-term in vivo IL-7Rα blockade inhibited the activation and expansion of autoantigen-specific CD4(+) T cells and, when used to treat experimental autoimmune encephalomyelitis (EAE), prevented and ameliorated disease. Our studies demonstrate that IL-7 signaling is a prerequisite for optimal CD4(+) T cell activation and that IL-7R antagonism may be effective in treating CD4(+) T cell-mediated neuroinflammation and other autoimmune inflammatory conditions. PMID:26319414

  3. Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo.

    PubMed

    Simonetti, Francesco R; Sobolewski, Michele D; Fyne, Elizabeth; Shao, Wei; Spindler, Jonathan; Hattori, Junko; Anderson, Elizabeth M; Watters, Sarah A; Hill, Shawn; Wu, Xiaolin; Wells, David; Su, Li; Luke, Brian T; Halvas, Elias K; Besson, Guillaume; Penrose, Kerri J; Yang, Zhiming; Kwan, Richard W; Van Waes, Carter; Uldrick, Thomas; Citrin, Deborah E; Kovacs, Joseph; Polis, Michael A; Rehm, Catherine A; Gorelick, Robert; Piatak, Michael; Keele, Brandon F; Kearney, Mary F; Coffin, John M; Hughes, Stephen H; Mellors, John W; Maldarelli, Frank

    2016-02-16

    Reservoirs of infectious HIV-1 persist despite years of combination antiretroviral therapy and make curing HIV-1 infections a major challenge. Most of the proviral DNA resides in CD4(+)T cells. Some of these CD4(+)T cells are clonally expanded; most of the proviruses are defective. It is not known if any of the clonally expanded cells carry replication-competent proviruses. We report that a highly expanded CD4(+) T-cell clone contains an intact provirus. The highly expanded clone produced infectious virus that was detected as persistent plasma viremia during cART in an HIV-1-infected patient who had squamous cell cancer. Cells containing the intact provirus were widely distributed and significantly enriched in cancer metastases. These results show that clonally expanded CD4(+)T cells can be a reservoir of infectious HIV-1. PMID:26858442

  4. Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

    PubMed Central

    Simonetti, Francesco R.; Sobolewski, Michele D.; Fyne, Elizabeth; Shao, Wei; Spindler, Jonathan; Hattori, Junko; Anderson, Elizabeth M.; Watters, Sarah A.; Hill, Shawn; Wu, Xiaolin; Wells, David; Su, Li; Luke, Brian T.; Halvas, Elias K.; Besson, Guillaume; Penrose, Kerri J.; Yang, Zhiming; Kwan, Richard W.; Van Waes, Carter; Uldrick, Thomas; Citrin, Deborah E.; Kovacs, Joseph; Polis, Michael A.; Rehm, Catherine A.; Gorelick, Robert; Piatak, Michael; Keele, Brandon F.; Kearney, Mary F.; Coffin, John M.; Hughes, Stephen H.; Mellors, John W.; Maldarelli, Frank

    2016-01-01

    Reservoirs of infectious HIV-1 persist despite years of combination antiretroviral therapy and make curing HIV-1 infections a major challenge. Most of the proviral DNA resides in CD4+T cells. Some of these CD4+T cells are clonally expanded; most of the proviruses are defective. It is not known if any of the clonally expanded cells carry replication-competent proviruses. We report that a highly expanded CD4+ T-cell clone contains an intact provirus. The highly expanded clone produced infectious virus that was detected as persistent plasma viremia during cART in an HIV-1–infected patient who had squamous cell cancer. Cells containing the intact provirus were widely distributed and significantly enriched in cancer metastases. These results show that clonally expanded CD4+T cells can be a reservoir of infectious HIV-1. PMID:26858442

  5. CD4 T Cell Responses in Latent and Chronic Viral Infections

    PubMed Central

    Walton, Senta; Mandaric, Sanja; Oxenius, Annette

    2013-01-01

    The spectrum of tasks which is fulfilled by CD4 T cells in the setting of viral infections is large, ranging from support of CD8 T cells and humoral immunity to exertion of direct antiviral effector functions. While our knowledge about the differentiation pathways, plasticity, and memory of CD4 T cell responses upon acute infections or immunizations has significantly increased during the past years, much less is still known about CD4 T cell differentiation and their beneficial or pathological functions during persistent viral infections. In this review we summarize current knowledge about the differentiation, direct or indirect antiviral effector functions, and the regulation of virus-specific CD4 T cells in the setting of persistent latent or active chronic viral infections with a particular emphasis on herpes virus infections for the former and chronic lymphocytic choriomeningitis virus infection for the latter. PMID:23717308

  6. Nuclear Retention of Multiply Spliced HIV-1 RNA in Resting CD4+ T Cells

    PubMed Central

    Lassen, Kara G; Ramyar, Kasra X; Bailey, Justin R; Zhou, Yan; Siliciano, Robert F

    2006-01-01

    HIV-1 latency in resting CD4+ T cells represents a major barrier to virus eradication in patients on highly active antiretroviral therapy (HAART). We describe here a novel post-transcriptional block in HIV-1 gene expression in resting CD4+ T cells from patients on HAART. This block involves the aberrant localization of multiply spliced (MS) HIV-1 RNAs encoding the critical positive regulators Tat and Rev. Although these RNAs had no previously described export defect, we show that they exhibit strict nuclear localization in resting CD4+ T cells from patients on HAART. Overexpression of the transcriptional activator Tat from non-HIV vectors allowed virus production in these cells. Thus, the nuclear retention of MS HIV-1 RNA interrupts a positive feedback loop and contributes to the non-productive nature of infection of resting CD4+ T cells. To define the mechanism of nuclear retention, proteomic analysis was used to identify proteins that bind MS HIV-1 RNA. Polypyrimidine tract binding protein (PTB) was identified as an HIV-1 RNA-binding protein differentially expressed in resting and activated CD4+ T cells. Overexpression of PTB in resting CD4+ T cells from patients on HAART allowed cytoplasmic accumulation of HIV-1 RNAs. PTB overexpression also induced virus production by resting CD4+ T cells. Virus culture experiments showed that overexpression of PTB in resting CD4+ T cells from patients on HAART allowed release of replication-competent virus, while preserving a resting cellular phenotype. Whether through effects on RNA export or another mechanism, the ability of PTB to reverse latency without inducing cellular activation is a result with therapeutic implications. PMID:16839202

  7. Gut Microbial Membership Modulates CD4 T Cell Reconstitution and Function after Sepsis.

    PubMed

    Cabrera-Perez, Javier; Babcock, Jeffrey C; Dileepan, Thamotharampillai; Murphy, Katherine A; Kucaba, Tamara A; Badovinac, Vladimir P; Griffith, Thomas S

    2016-09-01

    Transient lymphopenia is one hallmark of sepsis, and emergent data indicate the CD4 T cell compartment in sepsis survivors is numerically and functionally altered (when examined at the Ag-specific level) compared with nonseptic control subjects. Previous data from our laboratory demonstrated Ag-independent, lymphopenia-induced homeostatic proliferation to be a contributing mechanism by which CD4 T cells numerically recover in sepsis survivors. However, we reasoned it is also formally possible that some CD4 T cells respond directly to Ag expressed by gut-resident microbes released during polymicrobial sepsis. The effect of gut microbiome leakage on CD4 T cells is currently unknown. In this study, we explored the number and function of endogenous CD4 T cells specific for segmented filamentous bacterium (SFB) after cecal ligation and puncture (CLP)-induced sepsis using mice that either contained or lacked SFB as a normal gut-resident microbe. Interestingly, SFB-specific CD4 T cells underwent Ag-driven proliferation in CLP-treated SFB(+), but not in SFB(-), mice. Moreover, CLP-treated SFB(+) mice showed resistance to secondary lethal infection with recombinant SFB Ag-expressing virulent Listeria (but not wild-type virulent Listeria), suggesting the CLP-induced polymicrobial sepsis primed for a protective response by the SFB-specific CD4 T cells. Thus, our data demonstrate that the numerical recovery and functional responsiveness of Ag-specific CD4 T cells in sepsis survivors is, in part, modulated by the intestinal barrier's health discreetly defined by individual bacterial populations of the host's microbiome. PMID:27448587

  8. Verifying the CFE treaty; Any role for technology

    SciTech Connect

    Allentuck, J. . Nuclear Energy Dept.)

    1991-01-01

    As recently as 1989, it was generally expected that arms control would provide vast opportunities for technologists to exercise their ingenuity in adapting the tried and true concepts of materials control to this novel regime. When the first phase of the Treaty on Conventional Armed Forces in Europe (the CFE Treaty) was finally agreed upon in October 1990, and signed on November 19, 1990, it became obvious that verification was less important than consensus. Aside from NTM, which receives only passing mention, technology, even at the level of what is commonly accepted practice in materials control, not to speak of advanced concepts, had no meaningful role. In this paper the non-existent role for new technology in the Phase I CFE verification process is explained. The explanation relies on the perception that the benefits of having a treaty in place are far greater than the risk from possible violations, the political liabilities that accompany the identification of insignificant violations and, the very large dimensions of a significant violation.

  9. Verifying the CFE treaty: Any role for technology

    SciTech Connect

    Allentuck, J.

    1991-01-01

    As recently as 1989, it was generally expected that arms control would provide vast opportunities for technologists to exercise their ingenuity in adapting the tried and true concepts of materials control to this novel regime. When the first phase of the Treaty on Conventional Armed Forces in Europe (the CFE Treaty) was finally agreed upon in October 1990, and signed on November 19, 1990, it became obvious that verification was less important than consensus. Aside from NTM, which receives only passing mention, technology, even at the level of what is commonly accepted practice in materials control, not to speak of advanced concepts, had no meaningful role. In this paper the non-existent role for new'' technology in the Phase I CFE verification process is explained. The explanation relies on (1) the perception that the benefits of having a treaty in place are far greater than the risk from possible violations, (2) the political liabilities that accompany the identification of insignificant violations and (3) the very large dimensions of a significant violation. 4 refs., 1 fig., 2 tabs.

  10. The AMB Treaty: Toward the 21st century

    SciTech Connect

    Bunn, M.

    1990-04-01

    Question regarding the ABM Treaty likely to arise fall into 3 main categories: (1) even elimination of the Krasnoyarsk radar will leave some ambiguities in the ABM Treaty's treatment of large phased-array radars (LPARs); agreed clarifications might help forestall future disagreements; (2) continuing issues are likely to be raised by the overlap between ABM and non-AMB technologies, such as air defense or antisatellite (ASAT) weapons; and (3) more specific limitations must be developed for new technologies, such as the lasers and infrared sensors under development in the SDI program. The fundamental criteria for judging proposed solutions to these problems are their ability to achieve the basic goals of the ABM Treaty in a verifiable manner, without unduly interfering with other important military or civilian missions, such as early warning or air defense, or with continued research on ABM. (Military missions whose restraint is desirable for other reasons, such as ASAT, might be limited without under-mining U.S. security). As with the original ABM negotiation, the goal must be to ensure that militarily significant nationwide ABM systems are prohibited, and that neither side can develop a ready base for quickly deploying such a nationwide system - whether by rapidly building additional ABM components, or by upgrading ostensibly non-ABM systems to have an ABM systems to have an ABM capability - without clearly and observably violating the accord.

  11. Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

    PubMed Central

    Delong, Thomas; Wiles, Timothy A.; Baker, Rocky L.; Bradley, Brenda; Barbour, Gene; Reisdorph, Richard; Kumar, Nitesh; Elso, Colleen M.; Armstrong, Michael; Powell, Roger L.; Reisdorph, Nichole; DeNicola, Megan; Bottino, Rita; Powers, Alvin C.; Harlan, David M.; Kent, Sally C.; Mannering, Stuart I.; Haskins, Kathryn

    2016-01-01

    Type 1 diabetes (T1D) is caused by T cell mediated destruction of the insulin-producing β cells. CD4 T cell responses play a central role in β-cell destruction but the identity of the epitopes recognized by pathogenic CD4 T cells remains unknown. To address this we used a panel of diabetes triggering CD4 T cell clones isolated from non-obese diabetic (NOD) mice. Here we show that these pathogenic CD4 T cells target peptide ligands that are formed by covalent crosslinking of proinsulin peptides to other peptides present in β-cell secretory granules. These hybrid insulin peptides (HIPs) are highly antigenic for CD4 T cells and can be detected by mass spectrometry in β-cells. CD4 T cells from the residual pancreatic islets of two organ donors who had T1D also recognize HIPs. The discovery that autoreactive T cells target hybrid peptides may explain how immune tolerance is broken in T1D. PMID:26912858

  12. SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells

    PubMed Central

    2012-01-01

    Background Quiescent CD4+ T lymphocytes are highly refractory to HIV-1 infection due to a block at reverse transcription. Results Examination of SAMHD1 expression in peripheral blood lymphocytes shows that SAMHD1 is expressed in both CD4+ and CD8+ T cells at levels comparable to those found in myeloid cells. Treatment of CD4+ T cells with Virus-Like Particles (VLP) containing Vpx results in the loss of SAMHD1 expression that correlates with an increased permissiveness to HIV-1 infection and accumulation of reverse transcribed viral DNA without promoting transcription from the viral LTR. Importantly, CD4+ T-cells from patients with Aicardi-Goutières Syndrome harboring mutation in the SAMHD1 gene display an increased susceptibility to HIV-1 infection that is not further enhanced by VLP-Vpx-treatment. Conclusion Here, we identified SAMHD1 as the restriction factor preventing efficient viral DNA synthesis in non-cycling resting CD4+ T-cells. These results highlight the crucial role of SAMHD1 in mediating restriction of HIV-1 infection in quiescent CD4+ T-cells and could impact our understanding of HIV-1 mediated CD4+ T-cell depletion and establishment of the viral reservoir, two of the HIV/AIDS hallmarks. PMID:23092122

  13. Use of MHC class II tetramers to investigate CD4+ T cell responses: problems and solutions.

    PubMed

    Cecconi, Virginia; Moro, Monica; Del Mare, Sara; Dellabona, Paolo; Casorati, Giulia

    2008-11-01

    MHC-class I tetramers technology enabled the characterization of peptide-specific T cells at the single cell level in a variety of studies. Several laboratories have also developed MHC-class II multimers to characterize Ag-specific CD4+ T cells. However, the generation and use of MHC-class II multimers seems more problematic than that of MHC-I multimers. We have generated HLA-DR*1101 tetramers in a versatile empty form, which can be loaded after purification with peptides of interest. We discuss the impact of critical biological and structural parameters for the optimal staining of Ag-specific CD4+ T cells using HLA-DR*1101 tetramers, such as: (i) activation state of CD4+ T cells; (ii) membrane trafficking in the target CD4+ T cells; (iii) binding characteristics of the loaded CD4 epitope. Our data indicate that reorganization of TCR on the plasma membrane upon CD4+ T cell activation, as well as an homogenous binding frame of the CD4 epitopes to the soluble HLA-DR monomer, are critical for a stable TCR/MHC-class II tetramer interaction. These factors, together with the low frequencies and affinities of specific CD4+ T cells, explain the need for in vitro expansion or ex vivo enrichment of specific T cells for the optimal visualization with MHC-class II tetramers. PMID:18612991

  14. Predictor for the effect of amino acid composition on CD4+ T cell epitopes preprocessing.

    PubMed

    Hoze, Ehud; Tsaban, Lea; Maman, Yaakov; Louzoun, Yoram

    2013-05-31

    Predictive tools for all levels of CD8+ T cell epitopes processing have reached a maturation level. Good prediction algorithms have been developed for proteasomal cleavage, TAP and MHC class I peptide binding. The same cannot be said of CD4+ T cell epitopes. While multiple algorithms of varying accuracy have been proposed for MHC class II peptide binding, the preprocessing of CD4+ T cell epitopes is still lacking a good prediction algorithm. CD4+ T cell epitopes generation includes several stages, not all which are well-defined. We here group these stages to produce a generic preprocessing stage predictor for the cleavage processes preceding the presentation of epitopes to CD4+ T cell. The predictor is learnt using a combination of in vitro cleavage experiments and observed naturally processed MHC class II binding peptides. The properties of the predictor highlight the effect of different factors on CD4+ T cell epitopes preprocessing. The most important factor emerging from the predictor is the secondary structure of the cleaved region in the protein. The effect of the secondary structure is expected since CD4+ T cell epitopes are not denatured before cleavage. A website developed based on this predictor is available at: http://peptibase.cs.biu.ac.il/PepCleave_cd4/. PMID:23481624

  15. Methodologies for the Analysis of HCV-Specific CD4+ T Cells

    PubMed Central

    Lokhande, Megha U.; Thimme, Robert; Klenerman, Paul; Semmo, Nasser

    2015-01-01

    Virus-specific CD4+ T cells play a major role in viral infections, such as hepatitis C virus (HCV). Viral clearance is associated with vigorous and multi-specific CD4+ T-cell responses, while chronic infection has been shown to be associated with weak or absent T-cell responses. Most of these studies have used functional assays to analyze virus-specific CD4+ T-cell responses; however, these and other detection methods have various limitations. Therefore, the important question of whether virus-specific CD4+ T cells are completely absent or primarily impaired in specific effector functions during chronic infection, has yet to be analyzed in detail. A novel assay, in which virus-specific CD4+ T-cell frequencies can be determined by de novo CD154 (CD40 ligand) expression in response to viral antigens, can help to overcome some of the limitations of functional assays and restrictions of multimer-based methods. This and other current established methods for the detection of HCV-specific CD4+ T cells will be discussed in this review. PMID:25767470

  16. Impact of nicotine on the interplay between human periodontal ligament cells and CD4+ T cells.

    PubMed

    Ge, Xin; Liu, Ying-Feng; Wong, Yong; Wu, Li-Zheng; Tan, Ling; Liu, Fen; Wang, Xiao-Jing

    2016-09-01

    Periodontitis is a common infectious disease associated with destruction of periodontal ligaments and alveolar bones. CD4(+) T cell-mediated immune response is involved in the progression of periodontitis. Tobacco consumption increases the risk of periodontal disease. However, the impact of nicotine on the interaction between human periodontal ligament (PDL) cells and CD4(+) T cells remains unrevealed. Our study aims to investigate the effect of nicotine on PDL cells and the cocultured CD4(+) T cells. The PDL cell cultures were established by explants from healthy individuals, exposed to nicotine or α-bungarotoxin (α-BTX), and incubated solely or in combination with CD4(+) T cells. Afterwards, cell viability, secreted cytokines, and matrix metalloproteinases (MMPs) were evaluated. In monoculture of PDL cells, nicotine dramatically repressed cell viability and increased apoptosis. Meanwhile, α-BTX largely reversed the nicotine-induced apoptosis and increased viability of PDL cells. Compared with the monoculture, MMP-1, MMP-3, interleukin (IL)-1β, IL-6, IL-17, and IL-21 in supernatant of cocultures were markedly elevated after treatment with nicotine. Moreover, α-BTX significantly attenuated nicotine-triggered production of these components either in mono- or co-cultures. In addition, PDL cell-derived CXCL12 following nicotine treatment recruited CD4(+) T cells. Above all, nicotine deteriorated periodontitis partially by promoting PDL cell-CD4(+) T cell-mediated inflammatory response and matrix degradation. PMID:26553320

  17. Simian immunodeficiency virus selectively infects proliferating CD4+ T cells in neonatal rhesus macaques

    PubMed Central

    Wang, Xiaolei; Xu, Huanbin; Pahar, Bapi; Alvarez, Xavier; Green, Linda C.; Dufour, Jason; Moroney-Rasmussen, Terri; Lackner, Andrew A.

    2010-01-01

    Infants infected with HIV have a more severe course of disease and persistently higher viral loads than HIV-infected adults. However, the underlying pathogenesis of this exacerbation remains obscure. Here we compared the rate of CD4+ and CD8+ T-cell proliferation in intestinal and systemic lymphoid tissues of neonatal and adult rhesus macaques, and of normal and age-matched simian immunodeficiency virus (SIV)–infected neonates. The results demonstrate infant primates have much greater rates of CD4+ T-cell proliferation than adult macaques, and that these proliferating, recently “activated” CD4+ T cells are infected in intestinal and other lymphoid tissues of neonates, resulting in selective depletion of proliferating CD4+ T cells in acute infection. This depletion is accompanied by a marked increase in CD8+ T-cell activation and production, particularly in the intestinal tract. The data indicate intestinal CD4+ T cells of infant primates have a markedly accelerated rate of proliferation and maturation resulting in more rapid and sustained production of optimal target cells (activated memory CD4+ T cells), which may explain the sustained “peak” viremia characteristic of pediatric HIV infection. Eventual failure of CD4+ T-cell turnover in intestinal tissues may indicate a poorer prognosis for HIV-infected infants. PMID:20716768

  18. Expression of fas protein on CD4+T cells irradiated by low level He-Ne

    NASA Astrophysics Data System (ADS)

    Nie, Fan; Zhu, Jing; Zhang, Hui-Guo

    2005-07-01

    Objective: To investigate the influence on the Expression of Fas protein on CD4+ T cells irradiated by low level He-Ne laser in the cases of psoriasis. Methods:the expression of CD4+ T Fas protein was determined in the casee of psoriasis(n=5) pre and post-low level laser irradiation(30 min、60min and 120min)by flow cytometry as compared withthe control(n=5). Results:In the cases of psoriasis,the expression of CD4+T FAS protein 21.4+/-3.1% was increased significantly than that of control group 16.8+/-2.1% pre-irradiation, p<0.05in the control,there is no difference between pre and post- irradiation,p>0.05in the cases , the expression of CD4+T Fas protein wae positively corelated to the irradiation times, when the energy density arrived to 22.92J/cm2(60 minutes)and 45.84J/cm2(120minutes), the expression of CD4+ T Fas protein was increased significantly as compared with pre-irradiation,p<0.05.Conclusion: The expression of CD4+T Fas protein may be increased by low level He-Ne laser irradiation ,the uncontrolled status of apoptosis could be corrected.

  19. 8 CFR 215.4 - Procedure in case of alien prevented from departing from the United States.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Procedure in case of alien prevented from... IMMIGRATION REGULATIONS CONTROLS OF ALIENS DEPARTING FROM THE UNITED STATES § 215.4 Procedure in case of alien prevented from departing from the United States. (a) Any alien, other than an enemy alien, whose...

  20. 8 CFR 215.4 - Procedure in case of alien prevented from departing from the United States.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Procedure in case of alien prevented from... IMMIGRATION REGULATIONS CONTROLS OF ALIENS DEPARTING FROM THE UNITED STATES § 215.4 Procedure in case of alien prevented from departing from the United States. (a) Any alien, other than an enemy alien, whose...

  1. Strategic defense and the ABM treaty: an examination of the effect of the ABM Treaty on US ballistic-missile defense programs, 1972-1986

    SciTech Connect

    Crouch, J.D. II

    1987-01-01

    This study examines how the ABM Treaty restraints and the arms control process that was a logical continuation of the ABM Treaty have effected US ballistic-missile defense programs from 1972 to 1986, including the Strategic Defense Initiative. It provides a thorough analysis of US ABM Treaty negotiating objectives and outcomes, concluding that the conceptual linkage between offense and defense established early in SALT was broken and never reforged in later negotiations or agreements. It examines how Soviet views of strategic defense differ from the US, and how those views are reflected in Soviet strategic defense programs. It concludes that the Soviet understanding is diametrically opposed to the US view of the ABM Treaty, and that this has contributed to the great disparity in strategic defense effort since the signing of the Treaty. Finally, US BMD programs are examined in detail both to set out a general history of their development and to examine specifically the ABM Treaty's effect on that development. US Programs were effected by the ABM Treaty's logic and spirit as much as they were constrained by specific limitations. The Strategic Defense Initiative has been similarly hampered by being entangled in the US-Soviet strategic arms control process. The thesis concludes with a review of alternative approaches to the ABM Treaty regime.

  2. Political and Legal Framework for the Development of Training Policy in the European Union. Part I--From the Treaty of Rome to the Treaty of Maastricht.

    ERIC Educational Resources Information Center

    Bainbridge, Steve; Murray, Julie

    2000-01-01

    Reviews the history of vocational training policy from the establishment of the European Economic Community in the Treaty of Rome in 1957 to the Treaty of Maastricht, which created the European Union in 1992. Discusses the evolution from a centralized legislative approach to a more user-oriented approach promoting mobility. (Contains 40…

  3. Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo

    PubMed Central

    2014-01-01

    Background Early HIV-1 infection causes massive CD4+ T cell death in the gut and translocation of bacteria into the circulation. However, the programmed cell death (PCD) pathways used by HIV-1 to kill CD4+ T cells in the gut, and the impact of microbial exposure on T cell loss, remain unclear. Understanding mucosal HIV-1 triggered PCD could be advanced by an ex vivo system involving lamina propria mononuclear cells (LPMCs). We therefore modeled the interactions of gut LPMCs, CCR5-tropic HIV-1 and a commensal gut bacterial species, Escherichia coli. In this Lamina Propria Aggregate Culture (LPAC) model, LPMCs were infected with HIV-1BaL by spinoculation and cultured in the presence or absence of heat killed E.coli. CD4+ T cell numbers derived from flow cytometry and viable cell counts were reported relative to mock infection. Viable cells were identified by viability dye exclusion (AqVi), and intracellular HIV-1 Gag p24 protein was used to identify infected cells. Annexin V and AqVi were used to identify apoptotic versus necrotic cells. Caspase-1 and Caspase-3 activities were blocked using specific inhibitors YVAD and DEVD, respectively. Results CD4+ T cell depletion following HIV-1 infection was reproducibly observed by 6 days post infection (dpi). Depletion at 6 dpi strongly correlated with infection frequency at 4 dpi, was significantly blocked by Efavirenz treatment, and was primarily driven by p24-negative cells that were predominantly necrotic. HIV-1 infection significantly induced CD4+ T-cell intrinsic Caspase-1 activity, whereas Caspase-1 inhibition, but not Caspase-3 inhibition, significantly blocked CD4+ T cell depletion. Exposure to E.coli enhanced HIV-1 infection and CD4+ T depletion, and significantly increased the number of apoptotic p24+ cells. Notably, CD4+ T cell depletion in the presence of E.coli was partially blocked by Caspase-3, but not by Caspase-1 inhibition. Conclusions In the LPAC model, HIV-1 induced Caspase-1 mediated pyroptosis in

  4. Chemistry, life, and the search for aliens

    NASA Astrophysics Data System (ADS)

    Benner, Steven A.

    2010-09-01

    While "life" may universally be a self-sustaining chemical system capable of Darwinian evolution, alien life may be quite different in its chemistry from the terran life that we know here on Earth. In this case, it will be difficult to recognize, especially if it has not advanced beyond the single cell life forms that have dominated much of the terran biosphere. This review summarizes what we might infer from general physical and chemical law about how such "weird" life might be structured, what solvents other than water it might inhabit, what genetic molecules it might contain, and what metabolism it might exploit.

  5. Work alienation and problem alcohol behavior.

    PubMed

    Greenberg, E S; Grunberg, L

    1995-03-01

    Using a sample of production workers from union, nonunion, producer cooperative, and employee stock ownership plan (ESOP) wood products mills in the Northwest, we test the general proposition that work alienation, defined as low job autonomy, low use of capacities, and lack of participation in decision-making in the workplace, is associated with heavy drinking and negative consequences from drinking. We find that the general proposition is supported, but that the pathways tend to be indirect rather than direct, mediated by feelings of job satisfaction and respondents' beliefs about the utility of drinking as a means of coping. PMID:7738330

  6. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commissioner for Examinations as provided in 8 CFR 103.3. (7) Requirements for alien entrepreneurs. An alien... this manner does not exempt the petitioner from the requirements of 8 CFR 204.6(j) (2) and (3) relating... meet the criteria set forth in 8 CFR 204.6(j)(4)(ii). (i) State designation of a high unemployment...

  7. 42 CFR 435.350 - Coverage for certain aliens.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Coverage for certain aliens. 435.350 Section 435... ISLANDS, AND AMERICAN SAMOA Optional Coverage of the Medically Needy § 435.350 Coverage for certain aliens... treatment of an emergency medical condition, as defined in § 440.255(c) of this chapter, to those...

  8. Widespread plant species: natives vs. aliens in our changing world

    USGS Publications Warehouse

    Stohlgren, Thomas J.; Pyšek, Petr; Kartesz, John; Nishino, Misako; Pauchard, Aníbal; Winter, Marten; Pino, Joan; Richardson, David M.; Wilson, John R.U.; Murray, Brad R.; Phillips, Megan L.; Ming-yang, Li; Celesti-Grapow, Laura; Font, Xavier

    2011-01-01

    Estimates of the level of invasion for a region are traditionally based on relative numbers of native and alien species. However, alien species differ dramatically in the size of their invasive ranges. Here we present the first study to quantify the level of invasion for several regions of the world in terms of the most widely distributed plant species (natives vs. aliens). Aliens accounted for 51.3% of the 120 most widely distributed plant species in North America, 43.3% in New South Wales (Australia), 34.2% in Chile, 29.7% in Argentina, and 22.5% in the Republic of South Africa. However, Europe had only 1% of alien species among the most widespread species of the flora. Across regions, alien species relative to native species were either as well-distributed (10 comparisons) or more widely distributed (5 comparisons). These striking patterns highlight the profound contribution that widespread invasive alien plants make to floristic dominance patterns across different regions. Many of the most widespread species are alien plants, and, in particular, Europe and Asia appear as major contributors to the homogenization of the floras in the Americas. We recommend that spatial extent of invasion should be explicitly incorporated in assessments of invasibility, globalization, and risk assessments.

  9. Widespread plant species: Natives versus aliens in our changing world

    USGS Publications Warehouse

    Stohlgren, T.J.; Pysek, P.; Kartesz, J.; Nishino, M.; Pauchard, A.; Winter, M.; Pino, J.; Richardson, D.M.; Wilson, J.R.U.; Murray, B.R.; Phillips, M.L.; Ming-yang, L.; Celesti-Grapow, L.; Font, X.

    2011-01-01

    Estimates of the level of invasion for a region are traditionally based on relative numbers of native and alien species. However, alien species differ dramatically in the size of their invasive ranges. Here we present the first study to quantify the level of invasion for several regions of the world in terms of the most widely distributed plant species (natives vs. aliens). Aliens accounted for 51.3% of the 120 most widely distributed plant species in North America, 43.3% in New South Wales (Australia), 34.2% in Chile, 29.7% in Argentina, and 22.5% in the Republic of South Africa. However, Europe had only 1% of alien species among the most widespread species of the flora. Across regions, alien species relative to native species were either as well-distributed (10 comparisons) or more widely distributed (5 comparisons). These striking patterns highlight the profound contribution that widespread invasive alien plants make to floristic dominance patterns across different regions. Many of the most widespread species are alien plants, and, in particular, Europe and Asia appear as major contributors to the homogenization of the floras in the Americas. We recommend that spatial extent of invasion should be explicitly incorporated in assessments of invasibility, globalization, and risk assessments. ?? 2011 Springer Science+Business Media B.V.

  10. 8 CFR 235.3 - Inadmissible aliens and expedited removal.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... asylum officer in accordance with 8 CFR 208.30. The examining immigration officer shall record sufficient... the United States in accordance with section 241(c) of the Act and 8 CFR part 241. (9) Waivers of... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Inadmissible aliens and expedited...

  11. 42 CFR 435.350 - Coverage for certain aliens.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Coverage for certain aliens. 435.350 Section 435... ISLANDS, AND AMERICAN SAMOA Optional Coverage of the Medically Needy § 435.350 Coverage for certain aliens... treatment of an emergency medical condition, as defined in § 440.255(c) of this chapter, to those...

  12. 42 CFR 435.350 - Coverage for certain aliens.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Coverage for certain aliens. 435.350 Section 435... ISLANDS, AND AMERICAN SAMOA Optional Coverage of the Medically Needy § 435.350 Coverage for certain aliens... treatment of an emergency medical condition, as defined in § 440.255(c) of this chapter, to those...

  13. 42 CFR 435.350 - Coverage for certain aliens.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Coverage for certain aliens. 435.350 Section 435... ISLANDS, AND AMERICAN SAMOA Optional Coverage of the Medically Needy § 435.350 Coverage for certain aliens... treatment of an emergency medical condition, as defined in § 440.255(c) of this chapter, to those...

  14. 8 CFR 235.3 - Inadmissible aliens and expedited removal.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... asylum officer in accordance with 8 CFR 208.30. The examining immigration officer shall record sufficient... the United States in accordance with section 241(c) of the Act and 8 CFR part 241. (9) Waivers of... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Inadmissible aliens and expedited...

  15. Making Marx Accessible: Understanding Alienated Labor through Experiential Learning

    ERIC Educational Resources Information Center

    Parrotta, Kylie L.; Buck, Alison R.

    2013-01-01

    We introduce an exercise designed to make Marx's theory of alienated labor accessible to students in a Sociology of Work class. Through a role-playing activity where students create and sell goods under conditions of both alienated and nonalienated labor, students actually experience the different material and social consequences of these…

  16. Teaching English as a Second Language to Incarcerated Aliens.

    ERIC Educational Resources Information Center

    Edelson, Adelaide

    A study of the status of the instruction of incarcerated aliens in English as a second language (ESL) was undertaken to learn what is known about the subject and to determine whether incarcerated aliens have unique learning problems associated with their status as foreign nationals. Information was gathered through interviews with professionals in…

  17. Undocumented Aliens and the Nation's Two-Year Colleges.

    ERIC Educational Resources Information Center

    Smith, Milton L.

    In fall 1984, a nationwide study was conducted to determine the impact of undocumented aliens on two-year colleges. Surveys were mailed to presidents of 1,195 two-year colleges, requesting information on the number of undocumented aliens currently enrolled at the colleges, their nations of origin, their admission status, special modifications or…

  18. 7 CFR 273.4 - Citizenship and alien status.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... residing in the same household as the alien at the time of the abuse, an alien whose child has been... unmarried dependent child of such Hmong or Highland Laotian who is under the age of 18 or if a full-time student under the age of 22; an unmarried child under the age of 18 or if a full time student under...

  19. 22 CFR 41.24 - International organization aliens.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false International organization aliens. 41.24... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Foreign Government Officials § 41.24 International organization aliens. (a) Definition of international organization. “International organization” means: (1) Any...

  20. 22 CFR 41.24 - International organization aliens.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false International organization aliens. 41.24... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Foreign Government Officials § 41.24 International organization aliens. (a) Definition of international organization. “International organization” means: (1) Any...

  1. 22 CFR 41.24 - International organization aliens.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false International organization aliens. 41.24... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Foreign Government Officials § 41.24 International organization aliens. (a) Definition of international organization. “International organization” means: (1) Any...

  2. 22 CFR 41.24 - International organization aliens.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false International organization aliens. 41.24... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Foreign Government Officials § 41.24 International organization aliens. (a) Definition of international organization. “International organization” means: (1) Any...

  3. 22 CFR 41.24 - International organization aliens.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false International organization aliens. 41.24... IMMIGRATION AND NATIONALITY ACT, AS AMENDED Foreign Government Officials § 41.24 International organization aliens. (a) Definition of international organization. “International organization” means: (1) Any...

  4. 42 CFR 435.350 - Coverage for certain aliens.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Coverage for certain aliens. 435.350 Section 435... ISLANDS, AND AMERICAN SAMOA Optional Coverage of the Medically Needy § 435.350 Coverage for certain aliens... treatment of an emergency medical condition, as defined in § 440.255(c) of this chapter, to those...

  5. Political Disenchantment: A Cognitive-Perceptual Theory of Political Alienation.

    ERIC Educational Resources Information Center

    Long, Samuel

    An investigation of a cognitive-perceptual model to measure adolescents' feelings of political alienation is reported. The model hypothesizes that fundamental to the political alienation process is a feared actual or potential loss of freedom; this process is called psychological reactance. The sample consisted of 460 senior high school students…

  6. Alienation and Depression in the Small Town Widow.

    ERIC Educational Resources Information Center

    Jolley, Janina M.

    Research has found that elderly widows are alienated, disengaged, and depressed. However, there is little consensus across theories as to the inter-relationship of these variables. The social interactionist theory that disengagement leads to chronic depression and alienation was tested for a group of widows (N=32) and married women (N=28) over the…

  7. 26 CFR 301.7701(b)-1 - Resident alien.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Resident alien. 301.7701(b)-1 Section 301.7701(b)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION PROCEDURE AND ADMINISTRATION Definitions § 301.7701(b)-1 Resident alien. (a) Scope. Section 301.7701(b)-1(b) provides rules...

  8. Alienation in Physical Education from the Perspectives of Children

    ERIC Educational Resources Information Center

    Spencer-Cavaliere, Nancy; Rintoul, Mary Ann

    2012-01-01

    The purpose of this exploratory study was to examine the phenomenon of alienation in physical education from the perspectives of children. Of particular interest were children's perspectives about the three constructs of alienation: (a) powerlessness, (b) meaninglessness, and (c) social isolation, as defined by Carlson (1995). A case study…

  9. 4T1 Murine Mammary Carcinoma Cells Enhance Macrophage-Mediated Innate Inflammatory Responses

    PubMed Central

    Madera, Laurence; Greenshields, Anna; Coombs, Melanie R. Power; Hoskin, David W.

    2015-01-01

    Tumor progression and the immune response are intricately linked. While it is known that cancers alter macrophage inflammatory responses to promote tumor progression, little is known regarding how cancers affect macrophage-dependent innate host defense. In this study, murine bone-marrow-derived macrophages (BMDM) were exposed to murine carcinoma-conditioned media prior to assessment of the macrophage inflammatory response. BMDMs exposed to 4T1 mammary carcinoma-conditioned medium demonstrated enhanced production of pro-inflammatory cytokines tumor necrosis factor α, interleukin-6, and CCL2 in response to lipopolysaccharide (LPS) while production of interleukin-10 remained unchanged. The increased LPS-induced production of pro-inflammatory cytokines was transient and correlated with enhanced cytokine production in response to other Toll-like receptor agonists, including peptidoglycan and flagellin. In addition, 4T1-conditioned BMDMs exhibited strengthened LPS-induced nitric oxide production and enhanced phagocytosis of Escherichia coli. 4T1-mediated augmentation of macrophage responses to LPS was partially dependent on the NFκB pathway, macrophage-colony stimulating factor, and actin polymerization, as well as the presence of 4T1-secreted extracellular vesicles. Furthermore, peritoneal macrophages obtained from 4T1 tumor-bearing mice displayed enhanced pro-inflammatory cytokine production in response to LPS. These results suggest that uptake of 4T1-secreted factors and actin-mediated ingestion of 4T1-secreted exosomes by macrophages cause a transient enhancement of innate inflammatory responses. Mammary carcinoma-mediated regulation of innate immunity may have significant implications for our understanding of host defense and cancer progression. PMID:26177198

  10. 4T1 Murine Mammary Carcinoma Cells Enhance Macrophage-Mediated Innate Inflammatory Responses.

    PubMed

    Madera, Laurence; Greenshields, Anna; Coombs, Melanie R Power; Hoskin, David W

    2015-01-01

    Tumor progression and the immune response are intricately linked. While it is known that cancers alter macrophage inflammatory responses to promote tumor progression, little is known regarding how cancers affect macrophage-dependent innate host defense. In this study, murine bone-marrow-derived macrophages (BMDM) were exposed to murine carcinoma-conditioned media prior to assessment of the macrophage inflammatory response. BMDMs exposed to 4T1 mammary carcinoma-conditioned medium demonstrated enhanced production of pro-inflammatory cytokines tumor necrosis factor α, interleukin-6, and CCL2 in response to lipopolysaccharide (LPS) while production of interleukin-10 remained unchanged. The increased LPS-induced production of pro-inflammatory cytokines was transient and correlated with enhanced cytokine production in response to other Toll-like receptor agonists, including peptidoglycan and flagellin. In addition, 4T1-conditioned BMDMs exhibited strengthened LPS-induced nitric oxide production and enhanced phagocytosis of Escherichia coli. 4T1-mediated augmentation of macrophage responses to LPS was partially dependent on the NFκB pathway, macrophage-colony stimulating factor, and actin polymerization, as well as the presence of 4T1-secreted extracellular vesicles. Furthermore, peritoneal macrophages obtained from 4T1 tumor-bearing mice displayed enhanced pro-inflammatory cytokine production in response to LPS. These results suggest that uptake of 4T1-secreted factors and actin-mediated ingestion of 4T1-secreted exosomes by macrophages cause a transient enhancement of innate inflammatory responses. Mammary carcinoma-mediated regulation of innate immunity may have significant implications for our understanding of host defense and cancer progression. PMID:26177198

  11. Parental alienation, DSM-5, and ICD-11: response to critics.

    PubMed

    Bernet, William; Baker, Amy J L

    2013-01-01

    There has been considerable interest among forensic practitioners in the proposals that parental alienation be included in the next editions of the Diagnostic and Statistical Manual of Mental Diseases (DSM) and The International Classification of Diseases (ICD). However, there has also been a great deal of misunderstanding about the proposals, and misinformation has been expressed in professional meetings, on websites, and in journal articles. In this article we address four common misunderstandings regarding parental alienation: that there is a lack of research to support it as a diagnosis; that adopting parental alienation as a diagnosis will lead to serious adverse consequences; that the advocates of parental alienation are driven by self-serving or malevolent motives; and that Richard Gardner should be criticized for self-publishing his description of parental alienation syndrome. PMID:23503183

  12. Columbia River Treaty 2014/2024 Review • Phase 1 Report

    SciTech Connect

    2010-07-01

    Under the Columbia River Treaty (Treaty or CRT) of 1964, Canada and the United States (U.S.) jointly regulate and manage the Columbia River as it flows from British Columbia into the U.S. The Treaty has provided substantial flood control and power generation benefits to both nations. The Treaty established Canadian and U.S. Entities as implementing agents for each government. British Columbia Hydro and Power Authority (BC Hydro) was designated as the Canadian Entity. The Bonneville Power Administration (BPA) Administrator and the U.S. Army Corps of Engineers (Corps) Division Engineer, Northwestern Division, were designated as the U.S. Entity. The Canadian and U.S. Entities are empowered by their respective governments with broad discretion to implement the existing Columbia River Treaty. They are not, however, authorized to terminate, renegotiate, or otherwise modify the Treaty. In the U.S., authority over international treaties rests with the President, assisted in foreign relations and international negotiations by the Department of State and subject in certain cases to the advice and consent of the U.S. Senate. In Canada, international treaties are within the prerogative of the executive branch of the federal government. Under current policy, treaties are tabled in the House of Commons, and are subject to a waiting period before the executive branch brings the treaty into effect. In the case of the Columbia River Treaty, Canada has assigned certain rights and obligations relating to the Treaty to British Columbia pursuant to the Canada-B.C. Agreement. The Phase 1 report is provided to those respective governmental bodies to support possible independent and/or joint decisions that may be made with respect to the future of the Treaty. The Treaty contains two important provisions that take effect on and after September 16, 2024, that could impact the current power and flood control benefits: 1. Canadian flood control obligations automatically change from a pre

  13. Political Alienation among Migrant Youths: Exploring the Mechanisms of Political Alienation and Acculturation among Migrant Youths in Norwegian Schools

    ERIC Educational Resources Information Center

    Solhaug, Trond

    2012-01-01

    This article addresses the following question: What characterizes the mechanisms of political alienation among non-Western immigrant students, and how might these mechanisms be related to student's acculturation attitudes? A theory of political alienation and acculturation is applied. Substantial quantitative data from Norwegian upper secondary…

  14. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

    NASA Astrophysics Data System (ADS)

    Doitsh, Gilad; Galloway, Nicole L. K.; Geng, Xin; Yang, Zhiyuan; Monroe, Kathryn M.; Zepeda, Orlando; Hunt, Peter W.; Hatano, Hiroyu; Sowinski, Stefanie; Muñoz-Arias, Isa; Greene, Warner C.

    2014-01-01

    The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood although apoptosis has been proposed as a key mechanism. We now show that caspase-3-mediated apoptosis accounts for the death of only a small fraction of CD4 T cells corresponding to those that are both activated and productively infected. The remaining over 95% of quiescent lymphoid CD4 T cells die by caspase-1-mediated pyroptosis triggered by abortive viral infection. Pyroptosis corresponds to an intensely inflammatory form of programmed cell death in which cytoplasmic contents and pro-inflammatory cytokines, including IL-1β, are released. This death pathway thus links the two signature events in HIV infection--CD4 T-cell depletion and chronic inflammation--and creates a pathogenic vicious cycle in which dying CD4 T cells release inflammatory signals that attract more cells to die. This cycle can be broken by caspase 1 inhibitors shown to be safe in humans, raising the possibility of a new class of `anti-AIDS' therapeutics targeting the host rather than the virus.

  15. IL-21-producer CD4+ T cell kinetics during primary simian immunodeficiency virus infection.

    PubMed

    Shi, Shoi; Seki, Sayuri; Matano, Tetsuro; Yamamoto, Hiroyuki

    2013-01-01

    IL-21 signaling is important for T cell and B cell-mediated clearance of chronic viral infections. While non-cognate follicular helper CD4+ T cells (TFH) are indicated to be pivotal in providing IL-21-mediated help to activated B cells within germinal centers, how this signaling may be disrupted in early AIDS virus infection is not clear. In this study, we assessed the lineage and kinetics of peripheral blood IL-21-producing CD4+ T cells in primary simian immunodeficiency virus (SIV) infection of rhesus macaques. After SIV challenge, antigen-nonspecific IL-21 production was observed in Th1, Th2 and Th17 cells with Th1 dominance. While IL-21+ Th2 and IL-21+ Th17 showed variable kinetics, an increase in total IL-21+ CD4+ T cells and IL-21+ Th1 from week 3 to week 8 was observed, preceding plasma SIV-specific IgG development from week 5 to week 12. SIV Gag-specific IL-21+ CD4+ T cells detectable at week 2 were decreased in frequencies at week 5. Results imply that kinetics of IL-21+ CD4+ T cells comprised of multiple lineages, potentially targeted by SIV with a bias of existing frequencies during their precursor stage, associate with availability of cooperative B-cell help provided through a proportionate precursor pool developing into TFH and subsequent anti-SIV antibody responses. PMID:23791954

  16. Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance.

    PubMed

    Sethi, Apoorva; Kulkarni, Neeraja; Sonar, Sandip; Lal, Girdhari

    2013-01-01

    Gene expression is tightly regulated in a tuneable, cell-specific and time-dependent manner. Recent advancement in epigenetics and non-coding RNA (ncRNA) revolutionized the concept of gene regulation. In order to regulate the transcription, ncRNA can promptly response to the extracellular signals as compared to transcription factors present in the cells. microRNAs (miRNAs) are ncRNA (~22 bp) encoded in the genome, and present as intergenic or oriented antisense to neighboring genes. The strategic location of miRNA in coding genes helps in the coupled regulation of its expression with host genes. miRNA together with complex machinery called RNA-induced silencing complex (RISC) interacts with target mRNA and degrade the mRNA or inhibits the translation. CD4 T cells play an important role in the generation and maintenance of inflammation and tolerance. Cytokines and chemokines present in the inflamed microenvironment controls the differentiation and function of various subsets of CD4 T cells [Th1, Th2, Th17, and regulatory CD4 T cells (Tregs)]. Recent studies suggest that miRNAs play an important role in the development and function of all subsets of CD4 T cells. In current review, we focused on how various miRNAs are regulated by cell's extrinsic and intrinsic signaling, and how miRNAs affect the transdifferentiation of subsets of CD4 T cell and controls their plasticity during inflammation and tolerance. PMID:23386861

  17. Temporal requirements for B cells in the establishment of CD4 T cell memory.

    PubMed

    Mollo, Sarah B; Zajac, Allan J; Harrington, Laurie E

    2013-12-15

    CD4 T cell memory generation is shaped by a number of factors, including the strength and duration of TCR signaling, as well as the priming environment, all of which can be modified by B cells. Studies using B cell-deficient mice indicate B cells play a critical role in generating effector and memory CD4 T cells; however, when and how B cells are acting to promote these responses has not yet been ascertained. In this study, we use anti-CD20 Ab depletion of B cells at different times following Listeria monocytogenes infection to show that B cells are necessary for the induction of optimal CD4 T cell memory, but not for the transition and maintenance of this population. Importantly, the prerequisite of B cells early postinfection is partially dependent on their expression of MHC class II. B cells are not only required during the priming phase, but also necessary for the initiation of robust secondary responses by memory CD4 T cells. Interestingly, the requirement during the recall response is independent of B cell Ag presentation. Overall, these studies demonstrate the temporally and functionally distinct roles for B cells in regulating CD4 T cell responses. PMID:24218454

  18. Human CD4+ T-Cells: A Role for Low-Affinity Fc Receptors

    PubMed Central

    Chauhan, Anil K.

    2016-01-01

    Both lymphoid and myeloid cells express Fc receptors (FcRs). Low-affinity FcRs engage circulating immune complexes, which results in the cellular activation and pro-inflammatory cytokine production. FcRs participate in the internalization, transport, and/or recycling of antibodies and antigens. Cytosolic FcRs also route these proteins to proteasomes and antigen-presentation pathways. Non-activated CD4+ T-cells do not express FcRs. Once activated, naive CD4+ T-cells express FcγRIIIa, which, upon IC ligation, provide a costimulatory signal for the differentiation of these cells into effector cell population. FcγRIIIa present on CD4+ T-cell membrane could internalize nucleic acid-containing ICs and elicit a cross-talk with toll-like receptors. FcγRIIIa common γ-chain forms a heterodimer with the ζ-chain of T-cell receptor complex, suggesting a synergistic role for these receptors. This review first summarizes our current understanding of FcRs on CD4+ T-cells. Thereafter, I will attempt to correlate the findings from the recent literature on FcRs and propose a role for these receptors in modulating adaptive immune responses via TLR signaling, nucleic acid sensing, and epigenetic changes in CD4+ T-cells. PMID:27313579

  19. Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance

    PubMed Central

    Sethi, Apoorva; Kulkarni, Neeraja; Sonar, Sandip; Lal, Girdhari

    2013-01-01

    Gene expression is tightly regulated in a tuneable, cell-specific and time-dependent manner. Recent advancement in epigenetics and non-coding RNA (ncRNA) revolutionized the concept of gene regulation. In order to regulate the transcription, ncRNA can promptly response to the extracellular signals as compared to transcription factors present in the cells. microRNAs (miRNAs) are ncRNA (~22 bp) encoded in the genome, and present as intergenic or oriented antisense to neighboring genes. The strategic location of miRNA in coding genes helps in the coupled regulation of its expression with host genes. miRNA together with complex machinery called RNA-induced silencing complex (RISC) interacts with target mRNA and degrade the mRNA or inhibits the translation. CD4 T cells play an important role in the generation and maintenance of inflammation and tolerance. Cytokines and chemokines present in the inflamed microenvironment controls the differentiation and function of various subsets of CD4 T cells [Th1, Th2, Th17, and regulatory CD4 T cells (Tregs)]. Recent studies suggest that miRNAs play an important role in the development and function of all subsets of CD4 T cells. In current review, we focused on how various miRNAs are regulated by cell's extrinsic and intrinsic signaling, and how miRNAs affect the transdifferentiation of subsets of CD4 T cell and controls their plasticity during inflammation and tolerance. PMID:23386861

  20. Access of protective antiviral antibody to neuronal tissues requires CD4 T-cell help.

    PubMed

    Iijima, Norifumi; Iwasaki, Akiko

    2016-05-26

    Circulating antibodies can access most tissues to mediate surveillance and elimination of invading pathogens. Immunoprivileged tissues such as the brain and the peripheral nervous system are shielded from plasma proteins by the blood-brain barrier and blood-nerve barrier, respectively. Yet, circulating antibodies must somehow gain access to these tissues to mediate their antimicrobial functions. Here we examine the mechanism by which antibodies gain access to neuronal tissues to control infection. Using a mouse model of genital herpes infection, we demonstrate that both antibodies and CD4 T cells are required to protect the host after immunization at a distal site. We show that memory CD4 T cells migrate to the dorsal root ganglia and spinal cord in response to infection with herpes simplex virus type 2. Once inside these neuronal tissues, CD4 T cells secrete interferon-γ and mediate local increase in vascular permeability, enabling antibody access for viral control. A similar requirement for CD4 T cells for antibody access to the brain is observed after intranasal challenge with vesicular stomatitis virus. Our results reveal a previously unappreciated role of CD4 T cells in mobilizing antibodies to the peripheral sites of infection where they help to limit viral spread. PMID:27225131

  1. Exogenous and endogenous hyaluronic acid reduces HIV infection of CD4+ T cells

    PubMed Central

    Li, Peilin; Fujimoto, Katsuya; Bourguingnon, Lilly; Yukl, Steven; Deeks, Steven; Wong, Joseph K

    2014-01-01

    Preventing mucosal transmission of HIV is critical to halting the HIV epidemic. Novel approaches to preventing mucosal transmission are needed. Hyaluronic acid (HA) is a major extracellular component of mucosa and the primary ligand for the cell surface receptor CD44. CD44 enhances HIV infection of CD4+ T cells, but the role of HA in this process is not clear. To study this, virions were generated with CD44 (HIVCD44) or without CD44 (HIVmock). Exogenous HA reduced HIV infection of unstimulated CD4+ T cells in a CD44-dependent manner. Conversely, hyaluronidase-mediated reduction of endogenous HA on the cell surface enhanced HIV binding to and infection of unstimulated CD4+ T cells. Exogenous HA treatment reduced activation of protein kinase C alpha via CD44 on CD4+ T cells during infection with HIVCD44. These results reveal new roles for HA during the interaction of HIV with CD4+ T cells that may be relevant to mucosal HIV transmission and could be exploitable as a future strategy to prevent HIV infection. PMID:24957217

  2. CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors

    PubMed Central

    Kalekar, Lokesh A.; Schmiel, Shirdi E.; Nandiwada, Sarada L.; Lam, Wing Y.; Barsness, Laura O.; Zhang, Na; Stritesky, Gretta L.; Malhotra, Deepali; Pauken, Kristen E.; Linehan, Jonathan L.; O’Sullivan, M. Gerard; Fife, Brian T.; Hogquist, Kristin A.; Jenkins, Marc K.; Mueller, Daniel L.

    2015-01-01

    The role that anergy, an acquired state of T cell functional unresponsiveness, plays in natural peripheral tolerance remains unclear. In this study, we demonstrate that anergy is selectively induced in fetal antigen-specific maternal CD4+ T cells during pregnancy. A naturally occurring subpopulation of anergic polyclonal CD4+ T cells, enriched in self antigen-specific T cell receptors, is also observed in healthy hosts. Neuropilin-1 expression in anergic conventional CD4+ T cells is associated with thymic regulatory T cell (Treg cell)-related gene hypomethylation, and this correlates with their capacity to differentiate into Foxp3+ Treg cells that suppress immunopathology. Thus, our data suggest that not only is anergy induction important in preventing autoimmunity, but it also generates the precursors for peripheral Treg cell differentiation. PMID:26829766

  3. IL-33 enhances retinoic acid signaling on CD4+ T cells.

    PubMed

    Gajardo, Tania; Pérez, Francisco; Terraza, Claudia; Campos-Mora, Mauricio; Noelle, Randolph J; Pino-Lagos, Karina

    2016-09-01

    Several molecules have been described as CD4+ T cells differentiation modulators and among them retinoic acid (RA) and more recently, IL-33, have been studied. Due to the similarities in T helper cell skewing properties between RA and IL-33, we asked whether IL-33 intersects, directly or indirectly, the RA signaling pathway. Total CD4+ T cells from DR5-luciferase mice were activated in the presence of RA with or without IL-33, and RA signaling was visualized using ex vivo imaging. Our results demonstrate that IL-33 itself is able to trigger RA signaling on CD4+ T cells, which is highly increased when IL-33 is added in conjunction with RA. This study presents IL-33 as a potential player that may synergize with RA in controlling T cell differentiation, and suggests that IL-33 may be an attractive target in controlling T cell differentiation in vivo. PMID:27322964

  4. IL-10-producing CD4+ T cells negatively regulate fucosylation of epithelial cells in the gut

    PubMed Central

    Goto, Yoshiyuki; Lamichhane, Aayam; Kamioka, Mariko; Sato, Shintaro; Honda, Kenya; Kunisawa, Jun; Kiyono, Hiroshi

    2015-01-01

    Fucosylated glycans on the surface of epithelial cells (ECs) regulate intestinal homeostasis by serving as attachment receptors and a nutrient source for some species of bacteria. We show here that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing CD4+ T cells. The number of fucosylated ECs was increased in the ileum of mice lacking T cells, especially those expressing αβ T cell receptor (TCR), CD4, and IL-10. No such effect was observed in mice lacking B cells. Adoptive transfer of αβTCR+ CD4+ T cells from normal mice, but not IL-10-deficient mice, normalized fucosylation of ECs. These findings suggest that IL-10-producing CD4+ T cells contribute to the maintenance of the function of ECs by regulating their fucosylation. PMID:26522513

  5. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells

    PubMed Central

    Bertin, Samuel; Aoki-Nonaka, Yukari; de Jong, Petrus Rudolf; Stanwood, Shawna R.; Srikanth, Sonal; Lee, Jihyung; To, Keith; Abramson, Lior; Yu, Timothy; Han, Tiffany; Touma, Ranim; Li, Xiangli; González-Navajas, José M.; Herdman, Scott; Corr, Maripat; Fu, Guo; Dong, Hui; Gwack, Yousang; Franco, Alessandra; Jefferies, Wilfred A.; Raz, Eyal

    2016-01-01

    TRPV1 is a Ca2+-permeable channel mostly studied as a pain receptor in sensory neurons. However, its role in other cell types is poorly understood. Here, we demonstrate that TRPV1 is functionally expressed in CD4+ T cells where it acts as a non-store-operated Ca2+ channel and contributes to T cell receptor (TCR)-induced Ca2+ influx, TCR signaling and T cell activation. In models of T cell-mediated colitis, TRPV1 promotes colitogenic T cell responses and intestinal inflammation. Furthermore, genetic and pharmacological inhibition of TRPV1 in human CD4+ T cells recapitulates the phenotype of murine Trpv1−/− CD4+ T cells. These findings suggest that TRPV1 inhibition could represent a new therapeutic strategy to restrain proinflammatory T cell responses. PMID:25282159

  6. Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function.

    PubMed

    Dintwe, One B; Day, Cheryl L; Smit, Erica; Nemes, Elisa; Gray, Clive; Tameris, Michele; McShane, Helen; Mahomed, Hassan; Hanekom, Willem A; Scriba, Thomas J

    2013-09-01

    Heterologous prime-boost strategies hold promise for vaccination against tuberculosis. However, the T-cell characteristics required for protection are not known. We proposed that boost vaccines should induce long-lived functional and phenotypic changes to T cells primed by Bacille Calmette Guerin (BCG) and/or natural exposure to mycobacteria. We characterized changes among specific CD4(+) T cells after vaccination with the MVA85A vaccine in adults, adolescents, and children. CD4(+) T cells identified with Ag85A peptide-bearing HLA class II tetramers were characterized by flow cytometry. We also measured proliferative potential and cytokine expression of Ag85A-specific CD4(+) T cells. During the effector phase, MVA85A-induced specific CD4(+) T cells coexpressed IFN-γ and IL-2, skin homing integrins, and the activation marker CD38. This was followed by contraction and a transition to predominantly IL-2-expressing, CD45RA(-) CCR7(+) CD27(+) or CD45RA(+) CCR7(+) CD27(+) specific CD4(+) T cells. These surface phenotypes were similar to Ag85A-specific T cells prior to MVA85A. However, functional differences were observed postvaccination: specific proliferative capacity was markedly higher after 6-12 months than before vaccination. Our data suggest that MVA85A vaccination may modulate Ag85A-specific CD4(+) T-cell function, resulting in greater recall potential. Importantly, surface phenotypes commonly used as proxies for memory T-cell function did not associate with functional effects of vaccination. PMID:23737382

  7. Increased Mucosal CD4+ T Cell Activation in Rhesus Macaques following Vaccination with an Adenoviral Vector

    PubMed Central

    Bukh, Irene; Calcedo, Roberto; Roy, Soumitra; Carnathan, Diane G.; Grant, Rebecca; Qin, Qiuyue; Boyd, Surina; Ratcliffe, Sarah J.; Veeder, Christin L.; Bellamy, Scarlett L.; Betts, Michael R.

    2014-01-01

    ABSTRACT The possibility that vaccination with adenovirus (AdV) vectors increased mucosal T cell activation remains a central hypothesis to explain the potential enhancement of HIV acquisition within the Step trial. Modeling this within rhesus macaques is complicated because human adenoviruses, including human adenovirus type 5 (HAdV-5), are not endogenous to macaques. Here, we tested whether vaccination with a rhesus macaque-derived adenoviral vector (simian adenovirus 7 [SAdV-7]) enhances mucosal T cell activation within rhesus macaques. Following intramuscular SAdV-7 vaccination, we observed a pronounced increase in SAdV-7-specific CD4+ T cell responses in peripheral blood and, more dramatically, in rectal mucosa tissue. Vaccination also induced a significant increase in the frequency of activated memory CD4+ T cells in SAdV-7- and HAdV-5-vaccinated animals in the rectal mucosa but not in peripheral blood. These fluctuations within the rectal mucosa were also associated with a pronounced decrease in the relative frequency of naive resting CD4+ T cells. Together, these results indicate that peripheral vaccination with an AdV vector can increase the activation of mucosal CD4+ T cells, potentially providing an experimental model to further evaluate the role of host-vector interactions in increased HIV acquisition after AdV vector vaccination. IMPORTANCE The possibility that vaccination with a human adenovirus 5 vector increased mucosal T cell activation remains a central hypothesis to explain the potential enhancement of human immunodeficiency virus (HIV) acquisition within the Step trial. In this study, we tested whether vaccination with a rhesus macaque-derived adenoviral vector in rhesus macaques enhances mucosal CD4+ T cell activation, the main cell target of simian immunodeficiency virus (SIV)/HIV. The results showed that vaccination with an adenoviral vector indeed increases activation of mucosal CD4+ T cells and potentially increases susceptibility to SIV

  8. DNA methylation analysis of CD4+ T cells in patients with psoriasis.

    PubMed

    Park, Geon Tae; Han, Jihye; Park, Sin-Gi; Kim, Sangsoo; Kim, Tae-Yoon

    2014-04-01

    Psoriasis is a chronic inflammatory skin disease that is characterized by aberrant cross-talk between keratinocytes and immune cells such as CD4+ T cells, resulting in keratinocyte hyperproliferation in the epidermis. DNA methylation, one of several epigenetic mechanisms, plays an important role in gene expression without changing the DNA sequence. Several studies have suggested the involvement of epigenetic regulation in skin lesions from patients with psoriasis. In this study, we investigated the genome-wide DNA methylation status of CD4+ T cells in patients with psoriasis compared with healthy subjects using methylated DNA immunoprecipitation sequencing (MeDIP-Seq). The results of MeDIP-Seq showed that the global methylation values of CD4+ T cells are higher in patients with psoriasis than in healthy controls, particularly in the promoter regions. Among the most hypermethylated genes in the promoter regions, we selected the genes whose expression is significantly reduced in the CD4+ T cells of psoriasis patients. Studies using the methylation inhibitor 5-azacytidine in vitro methylation assays have shown that the differential expression levels were associated with the methylation status of each gene. Bisulfite sequencing of the transcription start region of phosphatidic acid phosphatase type 2 domain containing 3 (PPAPDC3), one of the selected genes, showed hypermethylation in the CD4+ T cells of psoriasis patients. These results suggested that the methylation status, which is identified by MeDIP-Seq of the genes, was correlated with the mRNA expression level of the genes. Collectively, the DNA methylation status in CD4+ T cells might be associated with the pathogenesis of psoriasis. PMID:24323136

  9. Natural CD4+ T-Cell Responses against Indoleamine 2,3-Dioxygenase

    PubMed Central

    Munir, Shamaila; Larsen, Stine Kiaer; Iversen, Trine Zeeberg; Donia, Marco; Klausen, Tobias Wirenfeldt; Svane, Inge Marie; Straten, Per thor; Andersen, Mads Hald

    2012-01-01

    Background The enzyme indoleamine 2,3-dioxygenase (IDO) contributes to immune tolerance in a variety of settings. In cancer IDO is expressed within the tumor itself as well as in antigen-presenting cells in tumor-draining lymph nodes, where it endorses the establishment of peripheral immune tolerance to tumor antigens. Recently, we described cytotoxic CD8+ T-cell reactivity towards IDO-derived peptides. Methods and Findings In the present study, we show that CD4+ helper T cells additionally spontaneously recognize IDO. Hence, we scrutinized the vicinity of the previously described HLA-A*0201-restricted IDO-epitope for CD4+ T-cell epitopes. We demonstrated the presence of naturally occurring IDO-specific CD4+ T cells in cancer patients and to a lesser extent in healthy donors by cytokine release ELISPOT. IDO-reactive CD4+ T cells released IFN-γ, TNF-α, as well as IL-17. We confirm HLA class II-restriction by the addition of HLA class II specific blocking antibodies. In addition, we detected a trend between class I- and class II-restricted IDO responses and detected an association between IDO-specific CD4+ T cells and CD8+ CMV-responses. Finally, we could detect IL-10 releasing IDO-reactive CD4+ T cells. Conclusion IDO is spontaneously recognized by HLA class II-restricted, CD4+ T cells in cancer patients and in healthy individuals. IDO-specific T cells may participate in immune-regulatory networks where the activation of pro-inflammatory IDO-specific CD4+ responses may well overcome or delay the immune suppressive actions of the IDO-protein, which are otherwise a consequence of the early expression of IDO in maturing antigen presenting cells. In contrast, IDO-specific regulatory T cells may enhance IDO-mediated immune suppression. PMID:22539948

  10. Immunodominant HIV-1 Cd4+ T Cell Epitopes in Chronic Untreated Clade C HIV-1 Infection

    PubMed Central

    Ramduth, Danni; Day, Cheryl L.; Thobakgale, Christina F.; Mkhwanazi, Nompumelelo P.; de Pierres, Chantal; Reddy, Sharon; van der Stok, Mary; Mncube, Zenele; Nair, Kriebashne; Moodley, Eshia S.; Kaufmann, Daniel E.; Streeck, Hendrik; Coovadia, Hoosen M.; Kiepiela, Photini; Goulder, Philip J. R.; Walker, Bruce D.

    2009-01-01

    Background A dominance of Gag-specific CD8+ T cell responses is significantly associated with a lower viral load in individuals with chronic, untreated clade C human immunodeficiency virus type 1 (HIV-1) infection. This association has not been investigated in terms of Gag-specific CD4+ T cell responses, nor have clade C HIV-1–specific CD4+ T cell epitopes, likely a vital component of an effective global HIV-1 vaccine, been identified. Methodology/Principal Findings Intracellular cytokine staining was conducted on 373 subjects with chronic, untreated clade C infection to assess interferon-gamma (IFN-γ) responses by CD4+ T cells to pooled Gag peptides and to determine their association with viral load and CD4 count. Gag-specific IFN-γ–producing CD4+ T cell responses were detected in 261/373 (70%) subjects, with the Gag responders having a significantly lower viral load and higher CD4 count than those with no detectable Gag response (p<0.0001 for both parameters). To identify individual peptides targeted by HIV-1–specific CD4+ T cells, separate ELISPOT screening was conducted on CD8-depleted PBMCs from 32 chronically infected untreated subjects, using pools of overlapping peptides that spanned the entire HIV-1 clade C consensus sequence, and reconfirmed by flow cytometry to be CD4+ mediated. The ELISPOT screening identified 33 CD4+ peptides targeted by 18/32 patients (56%), with 27 of the 33 peptides located in the Gag region. Although the breadth of the CD4+ responses correlated inversely with viral load (p = 0.015), the magnitude of the response was not significantly associated with viral load. Conclusions/Significance These data indicate that in chronic untreated clade C HIV-1 infection, IFN-γ–secreting Gag-specific CD4+ T cell responses are immunodominant, directed at multiple distinct epitopes, and associated with viral control. PMID:19352428

  11. 8 CFR 244.5 - Temporary treatment benefits for eligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Temporary treatment benefits for eligible aliens. 244.5 Section 244.5 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION... for eligible aliens. (a) Prior to the registration period. Prior to the registration...

  12. 8 CFR 244.5 - Temporary treatment benefits for eligible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Temporary treatment benefits for eligible aliens. 244.5 Section 244.5 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION... for eligible aliens. (a) Prior to the registration period. Prior to the registration...

  13. 22 CFR 40.203 - Alien entitled to A, E, or G nonimmigrant classification.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Alien entitled to A, E, or G nonimmigrant... § 40.203 Alien entitled to A, E, or G nonimmigrant classification. An alien entitled to nonimmigrant... to receive an immigrant visa until the alien executes a written waiver of all rights,...

  14. 26 CFR 1.871-5 - Loss of residence by an alien.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Loss of residence by an alien. 1.871-5 Section 1... (CONTINUED) INCOME TAXES Nonresident Aliens and Foreign Corporations § 1.871-5 Loss of residence by an alien. An alien who has acquired residence in the United States retains his status as a resident until...

  15. 8 CFR 209.2 - Adjustment of status of alien granted asylum.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) Inadmissible alien. An applicant who is not admissible to the United States as described in 8 CFR 209.2(a)(1)(v... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Adjustment of status of alien granted asylum. 209.2 Section 209.2 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY...

  16. 22 CFR 40.203 - Alien entitled to A, E, or G nonimmigrant classification.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Alien entitled to A, E, or G nonimmigrant... § 40.203 Alien entitled to A, E, or G nonimmigrant classification. An alien entitled to nonimmigrant... to receive an immigrant visa until the alien executes a written waiver of all rights,...

  17. 26 CFR 1.871-2 - Determining residence of alien individuals.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Determining residence of alien individuals. 1...) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Nonresident Aliens and Foreign Corporations § 1.871-2 Determining residence of alien individuals. (a) General. The term nonresident alien individual means...

  18. 8 CFR 1209.2 - Adjustment of status of alien granted asylum.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Adjustment of status of alien granted asylum. 1209.2 Section 1209.2 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS OF REFUGEES AND ALIENS GRANTED ASYLUM §...

  19. 22 CFR 40.93 - Aliens unlawfully present after previous immigration violation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Aliens unlawfully present after previous... TO BOTH NONIMMIGRANTS AND IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.93 Aliens unlawfully present after previous immigration violation. An alien...

  20. 22 CFR 40.203 - Alien entitled to A, E, or G nonimmigrant classification.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Alien entitled to A, E, or G nonimmigrant... § 40.203 Alien entitled to A, E, or G nonimmigrant classification. An alien entitled to nonimmigrant... to receive an immigrant visa until the alien executes a written waiver of all rights,...