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Sample records for 4-year period results

  1. Results from the first 4 years of pay for performance.

    PubMed

    DeVore, Susan D

    2010-01-01

    Some of the lessons hospitals that have participated in the Hospital Quality Incentive Demonstration project have learned include: the need to tie in quality-of-care initiatives to the organization's strategic plan and to incentive plans for all employees, from executives on down; the value in allowing hospital physicians to "own" quality improvement initiatives; the importance of making results of the initiative available to all staff; the benefit of creating best-practice teams to address improvements in specific clinical areas. PMID:20088476

  2. Antibiotic Consumption During a 4-year Period in a Community Hospital with an Antimicrobial Stewardship Program

    PubMed Central

    Garcell, Humberto Guanche; Arias, Ariadna Villanueva; Fernandez, Eliezer Alemán; Guerrero, Yaquelín Batista; Serrano, Ramon N. Alfonso

    2016-01-01

    Objectives We sought to evaluate the trend of antibiotic consumption in patients admitted to a community hospital in Qatar with an antimicrobial stewardship program. Methods This observational study was carried out in a 75-bed facility in Western Qatar over a 4-year period (2012–2015). The monitoring of antimicrobial consumption from inpatient wards was performed from the pharmacy records and presented as defined daily dose (DDD) divided by the patient days and expressed as 100 bed-days (DBD). Results The consumption of antimicrobials in 2012 was 171.3 DBD, and increased to 252.7 DBD in 2013, 229.1 DBD in 2014, and 184.7 DBD in 2015. Cephalosporins use reduced from 98.2 DBD in 2013 to 51.5 DBD in 2015 while the consumption of penicillins increased during the beginning of 2014 with a slight decrease in 2015. Carbapenems consumption during 2014–2015 was lower than previous years, and vice-versa for aminoglycosides. Fluoroquinolones had a sustained increase with 37.1% increased consumption in 2015 compared to the two previous years. There was an increase in the use of intravenous (IV) (108.5%) and oral azithromycin (55.1%) and the use of oral (152.8%) and IV moxifloxacin (22.9%). Conclusions We observed a decrease in antibiotic use in patients admitted to a community hospital with an antimicrobial stewardship program, but the increase in fluoroquinolones consumption is a concern that requires focused strategies. PMID:27602189

  3. The Maudsley Early Onset Schizophrenia Study: Cognitive Function Over a 4-Year Follow-Up Period

    PubMed Central

    Frangou, Sophia; Hadjulis, Michael; Vourdas, Apostolos

    2008-01-01

    Generalized cognitive deficits have been consistently reported in adolescents with early onset schizophrenia (EOS; defined as onset before the age of 17 years). The impact on cognition of potential interactions between disease pathology and brain maturation remains unclear. We therefore compared cognitive function between 20 EOS patients and 20 healthy controls matched on age, gender, and parental socioeconomic status at 2 time points, when aged 15.58 (2.27) and after a mean interval of 4 ± 1.08 years when aged 19.46 (2.21) years. Repeated measures analyses revealed no differences between patients and controls in the degree of change over this time period in general intellectual function and planning ability as measured by the Tower of London. There was deterioration in the verbal memory and attentional control index scores from the Wechsler Memory Scale-Revised but relative improvement in Part A of the Trail Making Test. Patients’ level of symptomatology as well as the type and dose of medication were comparable at both time points. We conclude that most aspects of cognitive function remain relatively stable in EOS patients during adolescence; there is evidence for deterioration in immediate verbal memory and attention while speed of information processing may show improvement. PMID:18024468

  4. Dynamics of CO2-exchange and C-budgets due to soil erosion: Insights from a 4 years observation period

    NASA Astrophysics Data System (ADS)

    Hoffmann, Mathias; Albiac Borraz, Elisa; Garcia Alba, Juana; Augustin, Jürgen; Sommer, Michael

    2015-04-01

    Agriculture in the hummocky ground moraine landscape of NE-Germany is characterized by an increase in energy crop cultivation, like maize or sorghum. Both enhance lateral C fluxes by erosion and induce feedbacks on C dynamics of agroecosystems as a result of reduced wintertime plant cover and vigorous crop growth during summer. However, the actual impact of these phenomena on the CO2-sink/-source function of agricultural landscapes, is still not clear. Therefore, the interdisciplinary project "CarboZALF" was established in Dedelow/Prenzlau (NE-Germany) in 2009. Within the field experiment CarboZALF-D, CO2 fluxes for the soil-plant systems were monitored, covering typical landscape relevant soil states in respect to erosion and deposition, like Calcic Cutanic Luvisol and Endogleyic Colluvic Regosol. Automated chamber systems, each consisting of four transparent chambers (2.5 m height, basal area 2.25 m2), were placed along gradients at both measurement sites. Monitored CO2 fluxes were gap-filled on a high-temporal resolution by modelling ecosystem respiration (Reco), gross primary productivity (GPP) and net ecosystem exchange (NEE) based on parallel and continuous measurements of the CO2 exchange, soil and air temperatures as well as photosynthetic active radiation (PAR). Gap-filling was e.g. needed in case of chamber malfunctions and abrupt disturbances by farming practice. The monitored crop rotation was corn-winter wheat (2 a), sorghum-winter triticale and alfalfa (1.5 a). In our presentation we would like to show insights from a 4 years observation period, with prounounced differences between the eroded and the colluvial soil: The Endogleyic Colluvic Regosol showed higher flux rates for Reco, GPP and NEE compared to the Calcic Cutanic Luvisol. Site-specific NEE and C-balances were positively related to soil C-stocks as well as biomass production, and generated a minor C-sink in case of the Calcic Cutanic Luvisol and a highly variable C-source in case of the

  5. Clinical results and development of heterotopic ossification in total cervical disc replacement during a 4-year follow-up

    PubMed Central

    Suchomel, Petr; Jurák, Lubomír; Brabec, Radim; Bradáč, Ondřej; Elgawhary, Shamel

    2009-01-01

    Cervical total disc replacement (CTDR) aims to decrease the incidence of adjacent segment disease through motion preservation in the operated disc space. Ongoing data collection and increasing number of studies describing heterotopic ossification (HO) resulting in decreased mobility of implants, forced us to carefully evaluate our long-term clinical and morphological results of patients with CTDR. We present the first 54 consecutive patients treated with 65 ProdiscC™ prostheses during a 12-month period (2/2004–3/2005). All patients signed an informed consent and were included in prospective long-term study approved by hospital ethical committee. The 1- and 2-year follow-up analysis were available for all patients included and 4-year results for 50 patients (60 implants). Clinical (neck disability index-NDI, visual analog scale-VAS) and radiological follow-up was conducted at 1-, 2- and 4-years after the procedure. The Mehren/Suchomel modification of McAfee scale was used to classify the appearance of HO. Mean preoperative NDI was 34.5%, VAS for neck pain intensity 4.6 and VAS for arm pain intensity 5.0. At 1-, 2- and 4-year follow-up, the mean NDI was 30.7, 27.2, and 30.4, mean VAS for neck pain intensity 2.5, 2.1 and 2.9 and mean VAS for arm pain intensity pain 2.2, 1.9 and 2.3, respectively. Significant HO (grade III) was present in 45% of implants and segmental ankylosis (grade IV) in another 18% 4 years after intervention. This finding had no clinical consequences and 92% of patients would undergo the same surgery again. Our clinical results (NDI, VAS) are comparable with fusion techniques. Although, advanced non-fusion technology is used, a significant frequency of HO formation and spontaneous fusion in cervical disc replacement surgery must be anticipated during long-term follow-up. PMID:20035357

  6. Hydraulic residence time and iron removal in a wetland receiving ferruginous mine water over a 4 year period from commissioning.

    PubMed

    Kusin, F M; Jarvis, A P; Gandy, C J

    2010-01-01

    Analysis of residence time distribution (RTD) has been conducted for the UK Coal Authority's mine water treatment wetland at Lambley, Northumberland, to determine the hydraulic performance of the wetland over a period of approximately 4 years since site commissioning. The wetland RTD was evaluated in accordance with moment analysis and modelled based on a tanks-in-series (TIS) model to yield the hydraulic characteristics of system performance. Greater hydraulic performance was seen during the second site monitoring after 21 months of site operation i.e. longer hydraulic residence time to reflect overall system hydraulic efficiency, compared to wetland performance during its early operation. Further monitoring of residence time during the third year of wetland operation indicated a slight reduction in hydraulic residence time, thus a lower system hydraulic efficiency. In contrast, performance during the fourth year of wetland operation exhibited an improved overall system hydraulic efficiency, suggesting the influence of reed growth over the lifetime of such systems on hydraulic performance. Interestingly, the same pattern was found for iron (which is the primary pollutant of concern in ferruginous mine waters) removal efficiency of the wetland system from the second to fourth year of wetland operation. This may therefore, reflect the maturity of reeds for maintaining efficient flow distribution across the wetland to retain a longer residence time and significant fractions of water involved to enhance the extent of treatment received for iron attenuation. Further monitoring will be conducted to establish whether such performance is maintained, or whether efficiency decreases over time due to accumulation of dead plant material within the wetland cells. PMID:20962411

  7. Biofilters to treat the pesticides wastes from spraying applications: results after 4 years of study.

    PubMed

    Pigeon, O; De Vleeschouwer, C; Cors, F; Weickmans, B; Huyghebaert, B; Planchon, V; Pussemier, L; Culot, M

    2006-01-01

    Biofilters were developed in order to eliminate or reduce the quantity of pesticides from rinsing and cleaning waters of sprayers. Biofilters consist in 1, 2 or 3 plastic containers of 1 m3 placed in a vertical pile and containing a substrate elaborated from a homogenised mixture of local soil, chopped straw and compost able to absorb and degrade the pesticides. Biofilters are installed near the area for cleaning and rinsing the sprayer and the waste waters are pumped into the system. Since 2002, a pilot study is carried out in Belgium in order to evaluate the efficacy of these systems. Twenty pilot systems were installed since 2002 until 2004 in several farms, agricultural technical centres or schools and in a municipal maintenance service. The efficacy of the biofilters was studied for several chemical classes of herbicides (sulfonylurea, aryloxyalcanoic acids, chloroacetanilides), insecticides (pyrethroids, carbamates) and fungicides (dicarboximides, phenylamides, triazoles and strobilurines). The balance of the inputs and the outputs of the pesticides was determined by monitoring the elutes. The degradation kinetic of pesticides into the substrate was evaluated by analysing the pesticides into the substrate. The microbiological activity of the substrate was also evaluated by measuring respiration and some indirect parameters like dry matter content, Kjeldahl nitrogen content, organic carbon content and biological oxygen demand (BOD). Results obtained until now after four years of experiments have showed an overall good efficacy (retention) of pesticides by the biofilter and a high degradation rate for the majority of pesticides. Biofilters permit to reduce highly the quantity of pesticides from rinsing and cleaning waters of sprayers and contribute significantly to the reduction of the contamination of surface water. Biofilters are now registered by the Ministry of Agriculture and Environment of the Walloon Region in Belgium and are recommended to pesticides

  8. The Change of Grip Strength in a Patient with Congenital Myotonic Dystrophy Over a 4-year Period

    PubMed Central

    Kozuka, Naoki; Uchida, Eiji; Ninomiya, Takafumi; Tatsumi, Haruyuki; Takeda, Hidekatsu; Tachi, Nobutada

    2008-01-01

    Myotonic dystrophy (MyD) is a neuromuscular disease that is autosomal dominant and the most common form of muscular dystrophy affecting adults. The clinical features of MyD include a multisystemic disorder characterized by myotonia, progressive muscle weakness and wasting, cataracts, premature balding and mental retardation. The most severe type of MyD is classified as congenital MyD (CMyD). The muscle weakness in CMyD is very severe, but muscle development can be observed in the period of growth. However, no clinical case of this type has been reported yet. Therefore, we report on a girl with CMyD who had an increase in muscle strength over a four-year period. The girl with CMyD participated in this study from the age of 9 to the age of 12. The measurement of muscle strength was recorded as the maximum score of grip strength with the use of dynamometers. Grip strength was assessed once a year by the same two physical therapists. Grip strength of CMyD for each year was markedly weak when compared with the normal controls, but muscle strength changed within some specific growth areas. The muscle weakness in CMyD was remarkable, but the result showed that specific muscle strength of CMyD in childhood was actually increased. PMID:25792886

  9. HST AND OPTICAL DATA REVEAL WHITE DWARF COOLING, SPIN, AND PERIODICITIES IN GW LIBRAE 3-4 YEARS AFTER OUTBURST

    SciTech Connect

    Szkody, Paula; Mukadam, Anjum S.; Gaensicke, Boris T. E-mail: mukadam@astro.washington.edu; and others

    2012-07-10

    Since the large amplitude 2007 outburst which heated its accreting, pulsating white dwarf, the dwarf nova system GW Librae has been cooling to its quiescent temperature. Our Hubble Space Telescope ultraviolet spectra combined with ground-based optical coverage during the third and fourth year after outburst show that the fluxes and temperatures are still higher than quiescence (T = 19,700 K and 17,300 K versus 16,000 K pre-outburst for a log g = 8.7 and d = 100 pc). The K{sub wd} of 7.6 {+-} 0.8 km s{sup -1} determined from the C I {lambda}1463 absorption line, as well as the gravitational redshift implies a white dwarf mass of 0.79 {+-} 0.08 M{sub Sun }. The widths of the UV lines imply a white dwarf rotation velocity v sin i of 40 km s{sup -1} and a spin period of 209 s (for an inclination of 11 deg and a white dwarf radius of 7 Multiplication-Sign 10{sup 8} cm). Light curves produced from the UV spectra in both years show a prominent multiplet near 290 s, with higher amplitude in the UV compared to the optical, and increased amplitude in 2011 versus 2010. As the presence of this set of periods is intermittent in the optical on weekly timescales, it is unclear how this relates to the non-radial pulsations evident during quiescence.

  10. Clinical characteristics and outcomes on discharge of women admitted to a Medium Secure Unit over a 4-year period.

    PubMed

    Ribeiro, Rafael Bernardon; Tully, John; Fotiadou, Maria

    2015-01-01

    There are limited data on women in Medium Secure settings. This study aimed to address this by assessing the characteristics of 45 consecutive admissions to the female ward of a Medium Secure Unit in the United Kingdom over a four-year period. Data on demographics, clinical outcomes and from HONOS-Secure/HONOS and HCR-20 assessments were prospectively collected. Psychiatric diagnoses were recorded using ICD-10 criteria. Data on quality of life from WHO-QoL-BREF surveys were analysed. There was a high proportion of ethnic minorities (57.8%), high rates of childhood and adult abuse and low socioeconomic status. 62.2% of the patients had schizophrenia, 57.8% had multiple diagnoses. The median length of stay at discharge was 465.5 days. There were statistically significant reductions in rates of self-harm and HoNOS-Secure/HoNOS and HCR-20 scores following intervention. Scores on WHO-QoL-BREF compared favourably to a large-scale sample with mental health difficulties. Many characteristics of this sample were comparable to samples from similar populations. However the particularly high proportion of ethnic minorities suggested that the profile of our patients differs from nationwide samples. Intervention by our service was associated with reduced self-harm and improvements in well-defined clinical outcomes and quality of life measures using validated scales. PMID:25748885

  11. Large Renal Artery Aneurysm Treated with Guglielmi Detachable Coils: Procedural and 4-Year Follow-up Results

    SciTech Connect

    Damascelli, Bruno; Bartorelli, Antonio L.; Ticha, Vladimira; Trabattoni, Daniela; Lanocita, Rodolfo

    2008-07-15

    A large aneurysm of the left renal artery was found incidentally during abdominal ultrasound in a 39-year-old woman with no medical or family history of cardiovascular disease. Vascular pathology with a dysplastic appearance was confirmed by magnetic resonance angiography and the patient was offered transcatheter embolization. Since the position and size of the neck of the aneurysm could not be determined at angiography, detachable platinum coils were used for occlusion. The procedure was performed without complications. During a 4-year follow-up no alterations of renal function, recanalization of the aneurysm, or perfusion defects in the rest of the left renal circulation were noted.

  12. Maternal depression from pregnancy to 4 years postpartum and emotional/behavioural difficulties in children: results from a prospective pregnancy cohort study.

    PubMed

    Woolhouse, Hannah; Gartland, Deirdre; Mensah, Fiona; Giallo, Rebecca; Brown, Stephanie

    2016-02-01

    Considerable attention has been focused on women's mental health in the perinatal period and the subsequent impacts on children. Comparatively, we know much less about maternal depression at later time points and the potential implications for child mental health. The objective of this paper was to explore the association between maternal depression and child emotional/behavioural difficulties at 4 years postpartum, taking into account earlier episodes of perinatal depression. The Maternal Health Study is a prospective cohort study of 1,507 nulliparous women. Maternal depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS) in early pregnancy and at 3, 6 and 12 months postpartum and again at 4 years postpartum. Maternal depressive symptoms at 4 years postpartum were associated with significantly increased odds of child emotional/behavioural difficulties (odds ratio (OR) = 3.46, 95 % confidence interval (CI) = 2.21-5.43). This remained significant after adjusting for earlier episodes of perinatal depression and socio-demographic characteristics (OR = 2.07, 95 % CI = 1.18-3.63). We also observed a robust association between child difficulties at age 4 and measures of socio-economic disadvantage. Our findings suggest a pressing need to rethink current paradigms of maternal health surveillance and extend mental health surveillance and support to at least 4 years postpartum. PMID:26271281

  13. Flaw growth of 7075, 7475, 7050 and 7049 aluminum alloy plate in stress corrosion environments: 4-year marine atmosphere results

    NASA Technical Reports Server (NTRS)

    Hasse, K. R.; Dorward, R. C.

    1981-01-01

    After nearly 53 months of exposure to marine atmosphere, crack growth in SL DCB specimens from 7075, 7475, 7050, and 7049-T7X plate has slowed to the arbitrary 10 to the -10 power m/sec used to define threshold stress intensity. Because some specimens appear to be approaching crack arrest, the importance of self-loading from corrosion product wedging as a significant driving force for crack propagation in overaged materials is questioned. Crack length-time data were analyzed using a computer curve fitting program which minimized the effects of normal data scatter, and provided a clearer picture of material performance. Precracked specimen data are supported by the results of smooth specimen tests. Transgranular stress corrosion cracking was observed in TL DCB specimens from all four alloys. This process is extremely slow and is characterized by a striated surface morphology.

  14. Evaluating 4 years of atmospheric ammonia (NH3) over Europe using IASI satellite observations and LOTOS-EUROS model results

    NASA Astrophysics Data System (ADS)

    Van Damme, M.; Wichink Kruit, R. J.; Schaap, M.; Clarisse, L.; Clerbaux, C.; Coheur, P.-F.; Dammers, E.; Dolman, A. J.; Erisman, J. W.

    2014-08-01

    Monitoring ammonia (NH3) concentrations on a global to regional scale is a challenge. Due to the limited availability of reliable ground-based measurements, the determination of NH3 distributions generally relies on model calculations. Novel remotely sensed NH3burdens provide valuable insights to complement traditional assessments for clear-sky conditions. This paper presents a first quantitative comparison between Atmospheric Sounding Interferometer (IASI) satellite observations and LOTOS-EUROS model results over Europe and Western Russia. A methodology to account for the variable retrieval sensitivity of the measurements is described. Four years of data (2008-2011) highlight three main agricultural hot spot areas in Europe: the Po Valley, the continental part of Northwestern Europe, and the Ebro Valley. The spatial comparison reveals a good overall agreement of the NH3 distributions not only in these source regions but also over remote areas and over sea when transport is observed. On average, the measured columns exceed the modeled ones, except for a few cases. Large discrepancies over several industrial areas in Eastern Europe and Russia point to underestimated emissions in the underlying inventories. The temporal analysis over the three hot spot areas reveals that the seasonality is well captured by the model when the lower sensitivity of the satellite measurements in the colder months is taken into account. Comparison of the daily time series indicates possible misrepresentations of the timing and magnitude of the emissions. Finally, specific attention to biomass burning events shows that modeled plumes are less spread out than the observed ones. This is confirmed for the 2010 Russian fires with a comparison using in situ observations.

  15. Scheduling periodic jobs using imprecise results

    NASA Technical Reports Server (NTRS)

    Chung, Jen-Yao; Liu, Jane W. S.; Lin, Kwei-Jay

    1987-01-01

    One approach to avoid timing faults in hard, real-time systems is to make available intermediate, imprecise results produced by real-time processes. When a result of the desired quality cannot be produced in time, an imprecise result of acceptable quality produced before the deadline can be used. The problem of scheduling periodic jobs to meet deadlines on a system that provides the necessary programming language primitives and run-time support for processes to return imprecise results is discussed. Since the scheduler may choose to terminate a task before it is completed, causing it to produce an acceptable but imprecise result, the amount of processor time assigned to any task in a valid schedule can be less than the amount of time required to complete the task. A meaningful formulation of the scheduling problem must take into account the overall quality of the results. Depending on the different types of undesirable effects caused by errors, jobs are classified as type N or type C. For type N jobs, the effects of errors in results produced in different periods are not cumulative. A reasonable performance measure is the average error over all jobs. Three heuristic algorithms that lead to feasible schedules with small average errors are described. For type C jobs, the undesirable effects of errors produced in different periods are cumulative. Schedulability criteria of type C jobs are discussed.

  16. Developmental milestones record - 4 years

    MedlinePlus

    Normal childhood growth milestones - 4 years; Growth milestones for children - 4 years; Childhood growth milestones - 4 years ... care provider. PHYSICAL AND MOTOR During the fourth year, a child typically: Gains weight at the rate ...

  17. Scheduling periodic jobs that allow imprecise results

    NASA Technical Reports Server (NTRS)

    Chung, Jen-Yao; Liu, Jane W. S.; Lin, Kwei-Jay

    1990-01-01

    The problem of scheduling periodic jobs in hard real-time systems that support imprecise computations is discussed. Two workload models of imprecise computations are presented. These models differ from traditional models in that a task may be terminated any time after it has produced an acceptable result. Each task is logically decomposed into a mandatory part followed by an optional part. In a feasible schedule, the mandatory part of every task is completed before the deadline of the task. The optional part refines the result produced by the mandatory part to reduce the error in the result. Applications are classified as type N and type C, according to undesirable effects of errors. The two workload models characterize the two types of applications. The optional parts of the tasks in an N job need not ever be completed. The resulting quality of each type-N job is measured in terms of the average error in the results over several consecutive periods. A class of preemptive, priority-driven algorithms that leads to feasible schedules with small average error is described and evaluated.

  18. Fat Necrosis After Partial-Breast Irradiation With Brachytherapy or Electron Irradiation Versus Standard Whole-Breast Radiotherapy-4-Year Results of a Randomized Trial

    SciTech Connect

    Loevey, Katalin Fodor, Janos; Major, Tibor; Szabo, Eva; Orosz, Zsolt; Sulyok, Zoltan; Janvary, Levente; Froehlich, Georgina; Kasler, Miklos; Polgar, Csaba

    2007-11-01

    Purpose: To examine the incidence and clinical relevance of fat necrosis after accelerated partial-breast irradiation (PBI) using interstitial high-dose-rate brachytherapy (HDR-BT) in comparison with partial-breast electron irradiation (ELE) and whole-breast irradiation (WBI). Methods and Materials: Between 1998 and 2004, 258 early-stage breast cancer patients were randomized to receive 50 Gy WBI (n = 130) or PBI (n = 128). The latter consisted of either 7 x 5.2 Gy HDR-BT (n = 88) or 50 Gy ELE (n = 40). The incidence of fat necrosis, its impact on cosmetic outcome, accompanying radiologic features, and clinical symptoms were evaluated. Results: The 4-year actuarial rate of fat necrosis was 31.1% for all patients, and 31.9%, 36.5%, and 17.7% after WBI, HDR-BT and ELE, respectively (p{sub WBI/HDR-BT} = 0.26; p{sub WBI/ELE} = 0.11; p{sub ELE/HDR-BT} = 0.025). The respective rate of asymptomatic fat necrosis was 20.2%, 25.3%, and 10% of patients. The incidence of symptomatic fat necrosis was not significantly different after WBI (8.5%), HDR-BT (11.4%), and ELE (7.5%). Symptomatic fat necrosis was significantly associated with a worse cosmetic outcome, whereas asymptomatic fat necrosis was not. Fat necrosis was detectable with mammography and/or ultrasound in each case. Additional imaging examinations were required in 21% of cases and aspiration cytology in 42%. Conclusions: Asymptomatic fat necrosis is a common adverse event of breast-conserving therapy, having no significant clinical relevance in the majority of the cases. The incidence of both symptomatic and asymptomatic fat necrosis is similar after conventional WBI and accelerated partial-breast HDR-BT.

  19. Prevalence of drug resistance and culture-positive rate among microorganisms isolated from patients with ocular infections over a 4-year period

    PubMed Central

    Shimizu, Yusuke; Toshida, Hiroshi; Honda, Rio; Matsui, Asaki; Ohta, Toshihiko; Asada, Yousuke; Murakami, Akira

    2013-01-01

    Purpose To investigate the microbial isolates from patients with ocular infections and the trend in the emergence of levofloxacin-resistant strains over the past four years from 2006 to 2009 retrospectively. Patients and methods The subjects were 242 patients with ocular infections or traumas treated in our hospital including outpatients, inpatients, and emergency room patients. Most of them needed urgent care presenting with eye complaints, traumas, or decreased vision. Clinical samples were obtained from discharges, corneal, conjunctival tissues or vitreous fluid or aqueous humor, and cultured. Items for assessment included the patient’s age, the diagnosis, the prevalence of isolated bacteria, and the results of susceptibility tests for levofloxacin (LVFX) cefamezin (CEZ), gentamicin (GM) and vancomycin. This information was obtained from the patients’ medical records. Results There were 156 male patients and 86 female patients who were aged from 2 months old to 94 years old and mean age was 56.8 ± 24.2 years. Of the 242 patients, 78 (32.2%) had positive cultures. The culture-positive rate was significantly higher in male patients than female in total (P = 0.002) and in patients with corneal perforation (P = 0.005). Corneal perforation was the highest culture-positive rate (60.0%), followed by orbital cellulitis (56.5%), blepharitis (50.0%), dacryoadenitis (45.5%), conjunctivitis (38.2%), infectious corneal ulcer (28.5%) and endophthalmitis (24.7%). LVFX-resistant strains accounted for 40 out of a total of 122 strains (32.8%), and the minimum inhibitory concentration (MIC) was significantly higher in LVFX and GM compared with the other antibiotics. There were no vancomycin-resistant strains. Conclusion Attention should be paid to a possible future increase of strains with resistance to LVFX, as commonly prescribed ocular antibiotics bring emergence of resistant bacteria. Although no vancomycin-resistant strains were isolated this drug should be reserved as

  20. Cemented and screw-retained implant-supported single-tooth restorations in the molar mandibular region: A retrospective comparison study after an observation period of 1 to 4 years

    PubMed Central

    Peñarrocha-Diago, Miguel; Pradíes, Guillermo; Sola-Ruiz, María-Fernanda; Agustín-Panadero, Rubén

    2015-01-01

    Objectives: The aim of this study was to evaluate the survival and compare the appearance of different mechanical and biological complications, in screw-retained and cemented-retained single-tooth implant-supported restorations localized in the molar mandibular region, over a period of 1 to 4 years. Material and Methods: A retrospective study was carried out with a total of eighty implant-supported restorations, which were placed in eighty patients for prosthetic rehabilitation of a mandibular molar. Forty patients were rehabilitated with a cemented-retained restoration and the other forty with a screw-retained restoration. The presence of the following complications was recorded for both types of prostheses: Fractures of the ceramic veneering, loosening screws, mucositis and peri-implantitis. Debonding of the restoration was analyzed in the cemented-retained restoration group. The clinical survival of crowns was analyzed with a Kaplan-Meier test and the clinical complications were compared, using a Student t test and Log-rank test. Results: 27 patients registered some complication. The average rate of complications was 37,5% for cemented-retained restorations and 30% for screw-retained restorations. The complications more common in the cemented-retained restoration were the presence of mucositis (14,87%), while in the screw-retained restorations was the loosening screw (20%). Student t test and Log-Rank test found significant differences (p=0,001) between the screw loosening and presence of mucositis. Conclusions: The cemented-retained restorations seem to prevent screw loosening, but the presence of cement seem to increase the complications around the soft tissues, however in the screw-retained restorations the presence of mucositis and peri-implantitis are lower than cemented-retained restorations. The incidence of fracture of ceramic veneering was similar in both groups. Key words:Screw-retained restorations, cemented-retained restorations, screw loosening

  1. Results of 4-year analysis of conversion from calcineurin inhibitors to mTOR inhibitors in renal transplant patients: single-center experience.

    PubMed

    Sert, Mehmet; Celik, Ali; Kural, Kemal; Ersan, Sibel; Ataca, Pinar; Atila, Koray; Cavdar, Caner; Sifil, Aykut; Bora, Seymen; Gulay, Hüseyin; Camsari, Taner

    2011-01-01

    In this retrospective study, 83 patients were accepted. Mammalian target of rapamycin (mTOR) group consisting of 37 patients were converted from calcineurin inhibitors (CNI), and the control group included 46 patients (initially CNI-receiving patients). As a control-match of each mTOR inhibitor patient, the succeeding patient with transplantation who continued CNI therapy was chosen. All patients received CNI, MMF, and prednisolone as an immunosuppressive therapy initially. In comparison of two groups, there was no significant difference between sex, donor organ source, donor organ ischemia time, or mismatches. However, mean age between groups was significantly different (mTOR group: 48.3 ± 12, CNI group: 38.6 ± 11, p < 0.001). Decision of conversion to mTOR inhibitors in 30 patients was made by biopsy. The reasons for conversion were determined as CNI nephrotoxicity in 15 patients, chronic allograft nephropathy in 15 patients, malignancy in 6 patients, and renal artery stenosis in 1 patient. Basal glomerular filtration rates (GFRs) were markedly lower in mTOR group than in CNI group (38.8 mL/min vs. 72.7 mL/min). At the end of 48-month follow-ups, GFR increased from 38 mL/min to 54 mL/min in mTOR group; however, it decreased to 53 mL/min from 72 mL/min in CNI group. There was no difference left between the two groups in GFR after 4-year follow-up. Hyperlipidemia was higher in mTOR group. Acute rejection rates were similar. Cytomegalovirus (CMV) disease was more prevalent in CNI group. Graft failure developed due to secondary reasons, causing mortality in both groups. We suggest that conversion to mTOR inhibitors maintains and improves graft functions well. PMID:21787153

  2. Less increase of copeptin and MR-proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.

    PubMed

    Alehagen, Urban; Aaseth, Jan; Johansson, Peter

    2015-01-01

    Intervention with selenium and coenzyme Q10 have recently been found to reduce mortality and increase cardiac function. The mechanisms behind these effects are unclear. As selenium and coenzyme Q10 is involved in the anti-oxidative defence, the present study aimed to evaluate effects of selenium and coenzyme Q10 on copeptin and adrenomedullin as oxidative stress biomarkers. Therefore 437 elderly individuals were included and given intervention for 4 years. Clinical examination and blood samples were undertaken at start and after 18 and 48 months. Evaluations of copeptin and MR-proADM changes were performed using repeated measures of variance. Cardiovascular mortality was evaluated using a 10-year-period of follow-up, and presented in Kaplan-Meier plots. A significant increase in copeptin level could be seen in the placebo group during the intervention period (from 9.4 pmol/L to 15.3 pmol/L), compared to the active treatment group. The difference between the groups was confirmed in the repeated measurement of variance analyses (P = 0.031) with less copeptin increase in the active treatment group. Furthermore, active treatment appeared to protect against cardiovascular death both in those with high and with low copeptin levels at inclusion. Less increase of MR-proADM could also be seen during the intervention in the active treatment group compared to controls (P = 0.026). Both in those having an MR-proADM level above or below median level, significantly less cardiovascular mortality could be seen in the active treatment group (P = 0.0001, and P = 0.04 respectively). In conclusion supplementation with selenium and coenzyme Q10 during four years resulted in less concentration of both copeptin and MR-proADM. A cardioprotective effect of the supplementation was registered, irrespective of the initial levels of these biomarkers, and this protection was recognized also after 10 years of observation. PMID:26662217

  3. Retrieval Results of Unassisted Searches of Two General Periodical Indexes.

    ERIC Educational Resources Information Center

    Blackburn, Jennifer O.

    A survey of public library users was conducted regarding retrieval results of unassisted user searches in general periodical indexes. The data were analyzed to evaluate the impact or lack of impact of searching a CD-ROM index with loosely-controlled vocabulary and expanded-search capabilities (i.e., InfoTrac-General Periodicals Index) versus a…

  4. Scheduling real-time, periodic jobs using imprecise results

    NASA Technical Reports Server (NTRS)

    Liu, Jane W. S.; Lin, Kwei-Jay; Natarajan, Swaminathan

    1987-01-01

    A process is called a monotone process if the accuracy of its intermediate results is non-decreasing as more time is spent to obtain the result. The result produced by a monotone process upon its normal termination is the desired result; the error in this result is zero. External events such as timeouts or crashes may cause the process to terminate prematurely. If the intermediate result produced by the process upon its premature termination is saved and made available, the application may still find the result unusable and, hence, acceptable; such a result is said to be an imprecise one. The error in an imprecise result is nonzero. The problem of scheduling periodic jobs to meet deadlines on a system that provides the necessary programming language primitives and run-time support for processes to return imprecise results is discussed. This problem differs from the traditional scheduling problems since the scheduler may choose to terminate a task before it is completed, causing it to produce an acceptable but imprecise result. Consequently, the amounts of processor time assigned to tasks in a valid schedule can be less than the amounts of time required to complete the tasks. A meaningful formulation of this problem taking into account the quality of the overall result is discussed. Three algorithms for scheduling jobs for which the effects of errors in results produced in different periods are not cumulative are described, and their relative merits are evaluated.

  5. Results at 24 months from the prospective, randomized, multicenter Investigational Device Exemption trial of ProDisc-C versus anterior cervical discectomy and fusion with 4-year follow-up and continued access patients

    PubMed Central

    Delamarter, Rick B.; Murrey, Daniel; Janssen, Michael E.; Goldstein, Jeffrey A.; Zigler, Jack; Tay, Bobby K-B; Darden, Bruce

    2010-01-01

    Background Cervical total disk replacement (TDR) is intended to address pain and preserve motion between vertebral bodies in patients with symptomatic cervical disk disease. Two-year follow-up for the ProDisc-C (Synthes USA Products, LLC, West Chester, Pennsylvania) TDR clinical trial showed non-inferiority versus anterior cervical discectomy and fusion (ACDF), showing superiority in many clinical outcomes. We present the 4-year interim follow-up results. Methods Patients were randomized (1:1) to ProDisc-C (PDC-R) or ACDF. Patients were assessed preoperatively, and postoperatively at 6 weeks and 3, 6, 12, 18, 24, 36, and 48 months. After the randomized portion, continued access (CA) patients also underwent ProDisc-C implantation, with follow-up visits up to 24 months. Evaluations included Neck Disability Index (NDI), Visual Analog Scale (VAS) for pain/satisfaction, and radiographic and physical/neurologic examinations. Results Randomized patients (103 PDC-R and 106 ACDF) and 136 CA patients were treated at 13 sites. VAS pain and NDI score improvements from baseline were significant for all patients (P < .0001) but did not differ among groups. VAS satisfaction was higher at all time points for PDC-R versus ACDF patients (P = .0499 at 48 months). The percentage of patients who responded yes to surgery again was 85.6% at 24 months and 88.9% at 48 months in the PDC-R group, 80.9% at 24 months and 81.0% at 48 months in the ACDF group, and 86.3% at 24 months in the CA group. Five PDC-R patients (48 months) and no CA patients (24 months) had index-level bridging bone. By 48 months, approximately 4-fold more ACDF patients required secondary surgery (3 of 103 PDC-R patients [2.9%] vs 12 of 106 ACDF patients [11.3%], P = .0292). Of these, 6 ACDF patients (5.6%) required procedures at adjacent levels. Three CA patients required secondary procedures (24 months). Conclusions Our 4-year data support that ProDisc-C TDR and ACDF are viable surgical options for symptomatic cervical

  6. Observations and Performances “with distinction” by Physical Therapy Students in Clinical Education: Analysis of Checkboxes on the Physical Therapist Clinical Performance Instrument (PT-CPI) over a 4-Year Period

    PubMed Central

    Booth, Randy

    2015-01-01

    ABSTRACT Purpose: To describe how often the 24 performance criteria of the Physical Therapist Clinical Performance Instrument (PT-CPI) were not observed and how often they were rated exceptionally well for physical therapy (PT) students in relation to clinical placement descriptors. Methods: Indicators of “not observed,” performance “with distinction,” and “significant concerns” were tabulated from 1,460 clinical placements between 2008 and 2012. The rates for these indicators were evaluated with respect to catchment area, practice setting (hospital/institutional or community-based), practice area (musculoskeletal, cardiorespiratory, neurology, paediatrics, geriatrics, or variety), and level (junior to senior). Results: Of the 24 PT-CPI criteria, 15 had observation rates >95%. Of the other nine criteria, some showed significant differences in observation rates across level, practice setting, and practice area. Ratings of “with distinction” were awarded most often for criteria related to professionalism and communication and were awarded more often in community-based settings than in hospital/institutional settings. For some criteria, “with distinction” was awarded more often in paediatrics placements than in other areas. The “significant concerns” checkboxes were rarely used. Conclusions: The overall observation rates were very similar to those reported elsewhere. The findings related to performance “with distinction” and observation rates relative to setting and practice area are new contributions to physical therapy knowledge. PMID:25931650

  7. 4-Year Cohort Graduation Rate: Overview

    ERIC Educational Resources Information Center

    Pennsylvania Department of Education, 2010

    2010-01-01

    Federal law requires Pennsylvania, and all other states, to transition to a new calculation method for determining high school graduation rates. Beginning in 2012, using graduation data from the Classes of 2010 and 2011, the "4-Year Cohort Graduation Rate" calculation will replace the "4-Year Leaver Graduation Rate" calculation. The new…

  8. SMOS Mission completes 4 years in orbit

    NASA Astrophysics Data System (ADS)

    Kerr, Yann; Richaume, Philippe; Mialon, Arnaud; Cabot, François; Bitar, Ahmad Al; Delwart, Steven; Drush, Matthias; Mecklenburg, Susanne

    2014-05-01

    In early November 2013, the SMOS mission celebrated 4 years in orbit. Since its launch, this mission has given many opportunities for breaking new grounds. Shortly after launch, first global maps of soil moisture ever measured from space were produced. Since then, the achieved accuracy has continuously improved to match the requirements. The long term trends of surface moisture can now be closely linked to precipitation regime, and SMOS results have been successfully used in response to extreme events. On the other hand, ocean salinity results have also improved dramatically. Here again, some amazing results regarding river plumes or fresh water pools related to precipitation have been obtained. At last, new applications have been imagined in various fields such as of sea ice thickness, or hurricane winds. This presentation will give an extensive status of the mission, emphasizing the many lessons learned and demonstrating some outstanding results. Some perspectives on the mission and future missions will also be given. A particular emphasis will be given on new level 4 products currently being produced as well as comparisons with other existing sensors.

  9. Late juvenile metachromatic leukodystrophy treated with bone marrow transplantation; a 4-year follow-up study.

    PubMed

    Navarro, C; Fernández, J M; Domínguez, C; Fachal, C; Alvarez, M

    1996-01-01

    We treated a 28-year-old woman who had metachromatic leukodystrophy with bone marrow transplantation. Leukocyte arylsulfatase A levels increased to the donor's range after successful graft. Motor and sensory nerve conduction values did not change significantly in the 4 years after the transplant, and subcortical white matter lesions, as shown on MRI, remained stable during that period of time. The results, after 4 years of follow-up, indicate that the disease has not progressed and signs and symptoms are stabilized. PMID:8559389

  10. A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: design and baseline results of a 4-year cluster-randomised intervention trial.

    PubMed

    Gray, Darren J; Li, Yue-Sheng; Williams, Gail M; Zhao, Zheng-Yuan; Harn, Donald A; Li, Sheng-Ming; Ren, Mao-Yuan; Feng, Zeng; Guo, Feng-Ying; Guo, Jia-Gang; Zhou, Jie; Dong, Yu-Lan; Li, Yuan; Ross, Allen G; McManus, Donald P

    2014-08-01

    Despite major successes in its control over the past 50years, schistosomiasis japonica continues to be a public health problem in the People's Republic of China (P.R. China). Historically, the major endemic foci occur in the lakes and marshlands along the Yangtze River, areas where transmission interruption has proven difficult. The current endemic situation may alter due to the closure of the Three Gorges Dam. Considerable environmental and ecological changes are anticipated that may result in new habitats for the oncomelanid intermediate snail host of Schistosoma japonicum (Sj), thereby increasing the risk of transmission. The current national control program for P.R. China involves a multi-component integrated strategy but, despite targeting multiple transmission pathways, certain challenges remain. As the Chinese government pushes towards elimination, there is a requirement for additional tools, such as vaccination, for long-term prevention. Whereas the zoonotic nature of schistosomiasis japonica adds to the complexity of control, it provides a unique opportunity to develop a transmission blocking vaccine targeting bovines to assist in the prevention of human infection and disease. Mathematical modelling has shown that control options targeting the various transmission pathways of schistosomiasis japonica and incorporating bovine vaccination, mass human chemotherapy and mollusciciding could lead to its elimination from P.R. China. Here we present the study design and baseline results of a four-year cluster randomised intervention trial we are undertaking around the schistosomiasis-endemic Dongting Lake in Hunan Province aimed at determining the impact on schistosome transmission of the multi-component integrated control strategy, including bovine vaccination using a heterologous "prime-boost" delivery platform based on the previously tested SjCTPI vaccine. PMID:24929133

  11. The Effectiveness of Alcohol Policies in 4-Year Public Universities

    ERIC Educational Resources Information Center

    Walter, Gayle T.

    2010-01-01

    A problem facing American universities is heavy drinking by the student body which results in unintentional injuries and deaths, illegal offenses, sexual assault, altercations, and academic demise. The relationship between the type of alcohol policy enacted on campus and alcohol consumption among undergraduate students attending 4-year public…

  12. The OmegaWhite Survey for short period variable stars II: An overview of results from the first four years

    NASA Astrophysics Data System (ADS)

    Toma, R.; Ramsay, G.; Macfarlane, S.; Groot, P. J.; Woudt, P. A.; Dhillon, V.; Jeffery, C. S.; Marsh, T.; Nelemans, G.; Steeghs, D.

    2016-08-01

    OmegaWhite is a wide-field, high cadence, synoptic survey targeting fields in the southern Galactic plane, with the aim of discovering short period variable stars. Our strategy is to take a series of 39 s exposures in the g band of a 1 square degree of sky lasting 2 h using the OmegaCAM wide field imager on the VLT Survey Telescope (VST). We give an overview of the initial 4 years of data which covers 134 square degrees and includes 12.3 million light curves. As the fields overlap with the VLT Survey Telescope Hα Photometric Survey of the Galactic plane and Bulge (VPHAS+), we currently have ugriHα photometry for ˜1/3 of our fields. We find that a significant fraction of the light curves have been affected by the diffraction spikes of bright stars sweeping across stars within a few dozen of pixels over the two hour observing time interval due to the alt-az nature of the VST. We select candidate variable stars using a variety of variability statistics, followed by a manual verification stage. We present samples of several classes of short period variables, including: an ultra compact binary, a DQ white dwarf, a compact object with evidence of a 100 min rotation period, three CVs, one eclipsing binary with an 85 min period, a symbiotic binary which shows evidence of a 31 min photometric period, and a large sample of candidate δ Sct type stars including one with a 9.3 min period. Our overall goal is to cover 400 square degrees, and this study indicates we will find many more interesting short period variable stars as a result.

  13. Fecal Calprotectin in Healthy Children Aged 1-4 Years

    PubMed Central

    Zhu, Qingling; Li, Feng; Wang, Junli; Shen, Lixiao; Sheng, Xiaoyang

    2016-01-01

    Objective Calprotectin has been well emulated recently in adults as well as in children. The aim of this study was to assess fecal calprotectin concentrations in healthy children aged from 1 to 4 years. Methods Volunteers were enlisted from 3 nurseries. A brief questionnaire was used to ensure these children meet the inclusion criteria, and some clinical and sociodemographic factors were collected. Anthro software (version 3.1) was used to calculated Length-for-age Z-scores (LAZ), weight-for-age Z-scores (WAZ), and weight-for-length Z-scores (WLZ) respectively. Fecal calprotectin was detected by a commercially available ELISA. Results In total 274 children were recruited, with age ranging from 1 to 4 years old. The median FC concentration was 83.19 μg/g [range 4.58 to 702.50 μg/g, interquartile range (IQR) 14.69–419.45 μg/g] or 1.92 log10 μg/g (range 0.66 log10 to 2.85 log10 μg/g, IQR 1.17 log10-2.62 log10 μg/g). All of the children were divided into three groups, 1–2 years (12–24 months), 2–3 years (24–36 months), 3–4 years (36–48 months), with median FC concentrations 96.14 μg/g (1.98 log10 μg/g), 81.48 μg/g (1.91 log10 μg/g), 65.36 μg/g (1.82 log10 μg/g), respectively. There was similar FC level between boys and girls. FC concentrations showed a downward trend by the growing age groups. A statistic difference was found in FC concentrations among groups 1–2 years, 2–3 years and 3–4 years (P = 0.016). In inter-groups comparison, a significant difference was found between children aged 1–2 years and children aged 3–4 years (P = 0.007). A negative correlation trend was found between age and FC concentration (Spearman's rho = -0.167, P = 0.005) in all the participants. A simple correlation was performed among WLZ, WAZ, birth weight, or birth length with FC, and there was no correlation being observed. Conclusion Children aged from 1 to 4 years old have lower FC concentrations compared with healthy infants (<1years), and higher FC

  14. Outpatient angioplasty: 4-year experience in one practice.

    PubMed Central

    Payne, S. P.; Stanton, A.; Travers, P.; Glenn, D.; Hanel, K. C.

    1997-01-01

    Angioplasty is often performed as an inpatient procedure after preliminary angiography. In order to increase efficiency and patient comfort we introduced a policy of performing angioplasty for chronic leg ischaemia as an outpatient whenever possible, using duplex scanning to select suitable lesions. This paper examines the safety and feasibility of this policy over a 4-year period. We prospectively assessed 168 consecutive cases which were planned for outpatient angioplasty from a total of 190 cases undergoing angioplasty and found full agreement between duplex scanning and angiography in 92%. Six patients (4%) developed complications of angioplasty requiring admission and another five were admitted for unexpected organisational reasons. Thus, the complication rate of outpatient angioplasty was 4%. All complications were noted at the time of angioplasty with no unexpected readmissions. Angioplasty for leg ischaemia is feasible and safe to perform as an outpatient using duplex scanning to select appropriate cases. PMID:9326123

  15. Mars Exploration Rovers: 4 Years on Mars

    NASA Technical Reports Server (NTRS)

    Landis, Geoffrey A.

    2008-01-01

    This January, the Mars Exploration Rovers "Spirit" and "Opportunity" are starting their fifth year of exploring the surface of Mars, well over ten times their nominal 90-day design lifetime. This lecture discusses the Mars Exploration Rovers, presents the current mission status for the extended mission, some of the most results from the mission and how it is affecting our current view of Mars, and briefly presents the plans for the coming NASA missions to the surface of Mars and concepts for exploration with robots and humans into the next decade, and beyond.

  16. Organized Physical Activity in Young School Children Predicts Subsequent 4-Year Change in Body Mass Index

    PubMed Central

    Dunton, Genevieve; McConnell, Rob; Jerrett, Michael; Wolch, Jennifer; Lam, Claudia; Gilliland, Frank; Berhane, Kiros

    2012-01-01

    Objective To determine whether participation in organized outdoor team sports and structured indoor non-school activity programs in kindergarten and first grade predicted subsequent 4-year change in Body Mass Index (BMI) across the adiposity rebound period of childhood. Design Longitudinal cohort study. Setting Forty-five schools in 13 communities across Southern California. Participants Largely Hispanic and non-Hispanic white children (N = 4,550; average age at study entry 6.60 years, standard deviation 0.65). Main Exposures Parents completed questionnaires assessing physical activity, demographic characteristics and other relevant covariates at baseline. Data on built and social environmental variables were linked to the neighborhood around children’s homes using geographical information systems (GIS). Main Outcome Measures Each child’s height and weight were measured annually during 4-years of follow-up. Results After adjusting for several confounders, BMI increased at a 0.05 unit per year slower rate for children who participated in outdoor organized team sports at least twice per week as compared to children who did not. For participation in each additional indoor non-school structured activity classes, lessons, and program, BMI increased at a 0.05 unit per year slower rate, and the attained BMI level at age 10 was 0.48 units lower. Conclusions Engagement in organized sports and activity programs as early as kindergarten and the first grade may result in smaller increases in BMI during the adiposity rebound period of childhood. PMID:22869403

  17. Longitudinal study of amygdala volume and joint attention in 2- to 4-year-old children with autism

    PubMed Central

    Mosconi, Matthew W.; Hazlett, Heather Cody; Poe, Michele D.; Gerig, Guido; Smith, Rachel Gimpel

    2011-01-01

    Context Cerebral cortical volume enlargement has been reported in 2- to 4-year-olds with autism. Little is known about the volume of sub-regions during this period of development. The amygdala is hypothesized to be abnormal in volume and related to core clinical features in autism. Objective To examine amygdala volume at 2 years with follow-up at 4 years of age in children with autism and to explore the relationship between amygdala volume and selected behavioral features of autism. Design Longitudinal magnetic resonance imaging study. Setting University medical setting. Participants Fifty-two autistic and 33 control (11 developmentally delayed, 22 typically developing) children between 18 and 35 months (2 years) of age followed up at 42 to 59 months (4 years) of age. Main Outcome Measures Amygdala volumes in relation to joint attention ability measured with a new observational coding system, the Social Orienting Continuum and Response scale; group comparisons including total tissue volume, sex, IQ and age as covariates. Results Amygdala enlargement was observed in subjects with autism at both 2 and 4 years of age. Significant change over time in volume was observed, though the rate of change did not differ between groups. Amygdala volume was associated with joint attention ability at age 4 years in subjects with autism. Conclusions The amygdala is enlarged in autism relative to controls by age 2 years but shows no relative increase in magnitude between 2 and 4 years of age. A significant association between amygdala volume and joint attention suggests that alterations to this structure may be linked to a core deficit of autism. PMID:19414710

  18. A result on quasi-periodic solutions of a nonlinear beam equation with a quasi-periodic forcing term

    NASA Astrophysics Data System (ADS)

    Wang, Yi; Si, Jianguo

    2012-02-01

    In this paper, a quasi-periodically forced nonlinear beam equation {u_{tt}+u_{xxxx}+μ u+\\varepsilonφ(t)h(u)=0} with hinged boundary conditions is considered, where μ > 0, {\\varepsilon} is a small positive parameter, {φ} is a real analytic quasi-periodic function in t with a frequency vector ω = ( ω 1, ω 2 . . . , ω m ), and the nonlinearity h is a real analytic odd function of the form {h(u)=η_1u+η_{2bar{r}+1}u^{2bar{r}+1}+sum_{k≥ bar{r}+1}η_{2k+1}u^{2k+1},η_1,η_{2bar{r}+1} neq0, bar{r} in {mathbb {N}}.} The above equation admits a quasi-periodic solution.

  19. Sub-daily periodicities in the results of local monitoring using global navigation satellite systems

    NASA Astrophysics Data System (ADS)

    Kaftan, Vladimir; Ustinov, Alexander

    Nowadays the more attention is focused on the continuous monitoring by using of global navigation satellite systems (GNSS) in the study and control of stability of engineering structures and natural objects. The diurnal and semi-diurnal oscillations take place in high frequency GNSS observation. These waves are caused by the presence of the high frequency periodicities in changes of all geospheres, but also in systematic errors of GNSS techniques. Thus the diurnal variations are already found in the coordinates of global and regional networks of CORS stations. They are often related with the influence of Earth's diurnal tides. The purpose of this study is to examine the periodic variations in coordinate increments of local monitoring networks of engineering structures and the earth's surface. But in this case the tidal changes have a small influence because of the relative proximity of the network control points. Results of static GNSS observations in the local network with the control vectors baselines from 170 m to 4.3 km of length were used for the analysis of periodicities. The hourly time series of baseline components of the length of two months were analyzed. Three qualitatively different methods were applied: wavelet transformation (Morlet wavelet function), fast Fourier transformation (FFT), and sequential analysis of the dominant harmonics (dominant analysis) for the more sure detection of hidden periodicities. The results of determination of oscillation spectrum were obtained by the three methods mentioned above. For all baselines their good mutual agreement were obtained. Diurnal and semi-diurnal waves are mainly and the most vividly appeared in the horizontal components, in the height’s component there are also other periodicity of the high and low frequencies. The oscillation’s amplitude reaches 4 mm. It is necessary to clarify the nature of the observed oscillations, which will be the main subject of the following more detailed studies. It is

  20. Results of Laboratory and Industrial Tests of Periodic-Type Gas Generators

    NASA Astrophysics Data System (ADS)

    Karp, I. N.; P‧yanykh, K. E.; Antoshchuk, T. A.; Lysenko, A. A.

    2015-05-01

    Results of laboratory and industrial tests of periodic-type gas generators burning various solid biofuels have been presented. The tests were carried out with the aim of obtaining producer gas which could totally or partly replace natural gas in power equipment burning gaseous fuel. The energy and environmental characteristics of a boiler unit burning a mixture of producer gas and natural gas have been assessed.

  1. Association of Waist-Height Ratio with Diabetes Risk: A 4-Year Longitudinal Retrospective Study

    PubMed Central

    Son, Yoon Jeong; Kim, Jihyun; Park, Hye-Jeong; Park, Se Eun; Park, Cheol-Young; Lee, Won-Young; Oh, Ki-Won; Park, Sung-Woo

    2016-01-01

    Background Waist-to-height ratio (WHtR) is an easy and inexpensive adiposity index that reflects central obesity. In this study, we examined the association of various baseline adiposity indices, including WHtR, with the development of diabetes over 4 years of follow-up in apparently healthy Korean individuals. Methods A total of 2,900 nondiabetic participants (mean age, 44.3 years; 2,078 men) in a health screening program, who repeated the medical check-up in 2005 and 2009, were recruited. Subjects were divided into two groups according to development of diabetes after 4 years. The cut-off values of baseline body mass index (BMI), waist circumference (WC), and WHtR for the development of diabetes over 4 years were calculated. The sensitivity, specificity, and mean area under the receiver operator characteristic curve (AUROC) of each index were assessed. The odds ratio (OR) for diabetes development was analyzed for each of the three baseline adiposity indices. Results During the follow-up period, 101 new cases (3.5%) of diabetes were diagnosed. The cut-off WHtR value for diabetes development was 0.51. Moreover, WHtR had the highest AUROC value for diabetes development among the three adiposity indices (0.716, 95% confidence interval [CI], 0.669 to 0.763; 0.702, 95% CI, 0.655 to 0.750 for WC; 0.700, 95% CI, 0.651 to 0.750 for BMI). After adjusting for confounding variables, the ORs of WHtR and WC for diabetes development were 1.95 (95% CI, 1.14 to 3.34) and 1.96 (95% CI, 1.10 to 3.49), respectively. No significant differences were observed between the two groups regarding BMI. Conclusion Increased baseline WHtR and WC correlated with the development of diabetes after 4 years. WHtR might be a useful screening measurement to identify individuals at high risk for diabetes. PMID:26754587

  2. Periodic inspection on crop sprayers: results according to age of sprayers.

    PubMed

    Antuniassi, Ulisses R; Gandolfo, Marco A

    2005-01-01

    The objectives of the IPP Project--Periodic Inspection on Crop Sprayers--are to develop methods for sprayer certification, analyze quality on spray operation, propose an inspection system for crop sprayers in Brazil, improve environmental quality on spray operation, and reduce costs on chemical control for plant protection systems. Periodic inspections on crop sprayers are performed in several countries and are compulsory in most of them, and it is becoming an important tool for improvement and optimization of use of chemicals. The IPP Project in Brazil is funded by FAPESP--Fundação de Amparo à Pesquisa do Estado de São Paulo. The results so far showed that all the sprayers presented failures. However, most of them could be approved with minor services. As an example, 56.6% of the sprayers with more than 2 years of use presented leaks, 47% of them had damaged hoses and 80.5% presented bad tips (nozzles). These results indicate the need for better procedures of use and maintenance of sprayers, justifying the periodic inspection system. PMID:15656181

  3. Intergenerational Relations across 4 Years: Well-Being Is Affected by Quality, Not by Support Exchange

    ERIC Educational Resources Information Center

    Merz, Eva-Maria; Schuengel, Carlo; Schulze, Hans-Joachim

    2009-01-01

    Purpose: Providing support to an aging parent may pose challenges to adult children but also provide an opportunity to "give back" to loved ones. The current study investigated changes in emotional and instrumental support and quality across a period of 4 years. Additionally, associations between intergenerational support and well-being in adult…

  4. Communications with Mars During Periods of Solar Conjunction: Initial Study Results

    NASA Astrophysics Data System (ADS)

    Morabito, D.; Hastrup, R.

    2001-07-01

    During the initial phase of the human exploration of Mars, a reliable communications link to and from Earth will be required. The direct link can easily be maintained during most of the 780-day Earth-Mars synodic period. However, during periods in which the direct Earth-Mars link encounters increased intervening charged particles during superior solar conjunctions of Mars, the resultant effects are expected to corrupt the data signals to varying degrees. The purpose of this article is to explore possible strategies, provide recommendations, and identify options for communicating over this link during periods of solar conjunctions. A significant improvement in telemetry data return can be realized by using the higher frequency 32 GHz (Ka-band), which is less susceptible to solar effects. During the era of the onset of probable human exploration of Mars, six superior conjunctions were identified from 2015 to 2026. For five of these six conjunctions, where the signal source is not occulted by the disk of the Sun, continuous communications with Mars should be achievable. Only during the superior conjunction of 2023 is the signal source at Mars expected to lie behind the disk of the Sun for about one day and within two solar radii (0. 5 deg) for about three days.

  5. Temporal Trends of Suicide Mortality in Mainland China: Results from the Age-Period-Cohort Framework

    PubMed Central

    Wang, Zhenkun; Wang, Jinyao; Bao, Junzhe; Gao, Xudong; Yu, Chuanhua; Xiang, Huiyun

    2016-01-01

    The aim of this study is to explore the long-term trends of suicide mortality in China. We implemented the age-period-cohort (APC) framework, using data from the Global Burden of Disease Study 2013. Our results showed that the net drift of suicide mortality was −4.727% (95% CI: −4.821% to −4.634%) per year for men and −6.633% (95% CI: −6.751% to −6.515%) per year for women, and the local drift values were below 0 in all age groups (p < 0.01 for all) for both sexes during the period of 1994–2013. Longitudinal age curves indicated that, in the same birth cohort, suicide death risk increased rapidly to peak at the life stage of 20–24 years old and 15–24 years old for men and women, respectively, and then showed a decelerated decline, followed by a rise thereafter after 54 years old for men and a slight one after 69 years old for women. The estimated period and cohort RRs were found to show similar monotonic downward patterns (significantly with p < 0.01 for all) for both sexes, with more quickly decreasing for women than for men during the whole period. The decreasing trend of suicide was likely to be related to the economic rapid growth, improvements in health care, enhancement on the level of education, and increasing awareness of suicide among the public in China. In addition, fast urbanization and the effective control of pesticides and rodenticides might be the special reasons behind these trends we observed in this study. PMID:27527195

  6. Temporal Trends of Suicide Mortality in Mainland China: Results from the Age-Period-Cohort Framework.

    PubMed

    Wang, Zhenkun; Wang, Jinyao; Bao, Junzhe; Gao, Xudong; Yu, Chuanhua; Xiang, Huiyun

    2016-01-01

    The aim of this study is to explore the long-term trends of suicide mortality in China. We implemented the age-period-cohort (APC) framework, using data from the Global Burden of Disease Study 2013. Our results showed that the net drift of suicide mortality was -4.727% (95% CI: -4.821% to -4.634%) per year for men and -6.633% (95% CI: -6.751% to -6.515%) per year for women, and the local drift values were below 0 in all age groups (p < 0.01 for all) for both sexes during the period of 1994-2013. Longitudinal age curves indicated that, in the same birth cohort, suicide death risk increased rapidly to peak at the life stage of 20-24 years old and 15-24 years old for men and women, respectively, and then showed a decelerated decline, followed by a rise thereafter after 54 years old for men and a slight one after 69 years old for women. The estimated period and cohort RRs were found to show similar monotonic downward patterns (significantly with p < 0.01 for all) for both sexes, with more quickly decreasing for women than for men during the whole period. The decreasing trend of suicide was likely to be related to the economic rapid growth, improvements in health care, enhancement on the level of education, and increasing awareness of suicide among the public in China. In addition, fast urbanization and the effective control of pesticides and rodenticides might be the special reasons behind these trends we observed in this study. PMID:27527195

  7. Longitudinal relations between child vagal tone and parenting behavior: 2 to 4 years.

    PubMed

    Kennedy, Amy E; Rubin, Kenneth H; Hastings, Paul D; Maisel, Beth

    2004-07-01

    The longitudinal relations between physiological markers of child emotion regulation and maternal parenting practices were examined from 2 to 4 years of age. At Time 1, cardiac vagal tone was assessed for one hundred four 2-year-olds (54 females); their mothers completed an assessment of parenting styles. Two years later, at Time 2, 84 of the original participants were reassessed on measures of cardiac vagal tone and parenting style. Results indicated both baseline cardiac vagal tone and maternal parenting practices to be stable from 2 to 4 years of age. Children's cardiac vagal tone predicted specific parenting practices from the toddler to preschool years. Further, child cardiac vagal tone moderated maternal restrictive-parenting practices from 2 to 4 years of age; mothers of children who were highly or moderately physiologically dysregulated were more likely to report restrictive parenting practices at both 2 and 4 years of age. PMID:15229872

  8. The Neutral Atmosphere Parameters on Measurements Using the Artificial Periodic Irregularities. Techniques, processing, results.

    NASA Astrophysics Data System (ADS)

    Tolmacheva, Ariadna V.; Bakhmetieva, Nataliya V.; Grigoriev; Kalinina, Elena E.

    The measurements with the aid of the artificial periodic irregularities (APIs) were begun in 1990. The APIs are created in the ionosphere illuminated by a high power HF radio wave of a frequency below the critical one. The APIs diagnostics is based upon observation of the Bragg backscatter of the pulsed probe radio waves from the periodic structure. The amplitudes and phases of the probe signals back scattered by the APIs are measured. At the E-region heights the APIs relax in the ambipolar diffusion process. Based on this fact we could determine the neutral atmosphere parameters suggesting that the processes of isothermal on small scales (3-5 km) and the electron, ion and neutral temperatures are equal at the E-region heights. The atmospheric height scale H and the neutral atmospheric temperature T are determined on the height dependence of the relaxation times tau(z). The altitude step is about 3 km. Whole height interval of the measurements of τ is equal to about 20-30 km. Selecting small height intervals step by step we obtain altitude dependences T(z), nu(z) and rho(z). Such a way was employed because the steady state is achieved on the scales 20-30 km for a long time. We obtained a lot of information about dynamical phenomena in the lower thermosphere. These results are presented in the report. Firstly, there were temperature profiles with minimum about 100-140 K above 100 km in the equinoctial periods. But in summer of 1999 temperature maximum was observed on z = 100 km. Secondary, there were often profiles with the wave-like variations and with the vertical scale of about to 4-6 km. The temporal variations of the atmospheric parameters had periods from 15 minutes to some hours. These variations caused by the propagation of the internal gravity and tide waves. Planetary waves produce the longer temporal variations. Thirdly, we observed some cases of the instability growth. The dependencies of the atmospheric parameters on the solar and geomagnetic activity

  9. Results of IPS Observations in the Period Near Solar Activity Minimum

    NASA Astrophysics Data System (ADS)

    Chashei, I. V.; Shishov, V. I.; Tyul'bashev, S. A.; Subaev, I. A.; Oreshko, V. V.

    2013-07-01

    IPS observations with the Big Scanning Array of Lebedev Physical Institute (BSA LPI) radio telescope at the frequency 111 MHz have been monitored since 2006. All the sources, about several hundred daily, with a scintillating flux greater than 0.2 Jy are recorded for 24 hours in the 16 beams of the radio telescope covering a sky strip of 8∘ declination width. We present some results of IPS observations for the recent period of low solar activity considering a statistical ensemble of scintillating radio sources. The dependences of the averaged over ensemble scintillation index on heliocentric distance are considerably weaker than the dependence expected for a spherically symmetric geometry. The difference is especially pronounced in the year 2008 during the very deep solar activity minimum period. These features are explained by the influence of the heliospheric current sheet that is seen as a strong concentration of turbulent solar wind plasma aligned with the solar equatorial plane. A local maximum of the scintillation index is found in the anti-solar direction. Future prospects of IPS observations using BSA LPI are briefly discussed.

  10. Patch-test results in children and adolescents: systematic review of a 15-year period*

    PubMed Central

    Rodrigues, Dulcilea Ferraz; Goulart, Eugênio Marcos Andrade

    2016-01-01

    The number of studies on patch-test results in children and adolescents has gradually increased in recent years, thus stimulating reviews. This paper is a systematic review of a 15-year period devoted to studying the issue. Variations pertaining to the number and age groups of tested children and/or adolescents, the number of subjects with atopy/atopic dermatitis history, the quantity, type and concentrations of the tested substances, the test technique and type of data regarding clinical relevance, must all be considered in evaluating these studies, as they make it harder to formulate conclusions. The most common allergens in children were nickel, thimerosal, cobalt, fragrance, lanolin and neomycin. In adolescents, they were nickel, thimerosal, cobalt, fragrance, potassium dichromate, and Myroxylon pereirae. Knowledge of this matter aids health professionals in planning preventive programs aimed at improving children's quality of life and ensuring that their future prospects are not undermined. PMID:26982781

  11. Patch-test results in children and adolescents: systematic review of a 15-year period.

    PubMed

    Rodrigues, Dulcilea Ferraz; Goulart, Eugênio Marcos Andrade

    2016-02-01

    The number of studies on patch-test results in children and adolescents has gradually increased in recent years, thus stimulating reviews. This paper is a systematic review of a 15-year period devoted to studying the issue. Variations pertaining to the number and age groups of tested children and/or adolescents, the number of subjects with atopy/atopic dermatitis history, the quantity, type and concentrations of the tested substances, the test technique and type of data regarding clinical relevance, must all be considered in evaluating these studies, as they make it harder to formulate conclusions. The most common allergens in children were nickel, thimerosal, cobalt, fragrance, lanolin and neomycin. In adolescents, they were nickel, thimerosal, cobalt, fragrance, potassium dichromate, and Myroxylon pereirae. Knowledge of this matter aids health professionals in planning preventive programs aimed at improving children's quality of life and ensuring that their future prospects are not undermined. PMID:26982781

  12. The Passive in 3- and 4-Year-Olds

    ERIC Educational Resources Information Center

    de Barros Pereira Rubin, Maraci Coelho

    2009-01-01

    This paper argues that analyzing the patterns of individual subject performance in tests of comprehension of passives might give insight into how little children interpret passives: 3 and 4 year-olds seem to go through a range of passive interpretation, that varies from actual comprehension to total non-comprehension. The fact that some small…

  13. 20 CFR 210.4 - Year of service.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Year of service. 210.4 Section 210.4... RAILROAD SERVICE § 210.4 Year of service. (a) A year of service is twelve months of reported or deemed service, consecutive or not consecutive. A fraction of a year of service is taken at its actual value....

  14. 20 CFR 210.4 - Year of service.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Year of service. 210.4 Section 210.4... RAILROAD SERVICE § 210.4 Year of service. (a) A year of service is twelve months of reported or deemed service, consecutive or not consecutive. A fraction of a year of service is taken at its actual value....

  15. Head Start, 4 years After Completing the Program

    ERIC Educational Resources Information Center

    Kim, Young-Joo

    2013-01-01

    This paper studies the effect of the Head Start program on children's achievements in reading and math tests during their first 4 years of schooling after completing the program. Using nationally representative data from the Early Childhood Longitudinal Study, I found large measurement error in the parental reports of Head Start attendance,…

  16. Grammatical Morpheme Production in 4-Year-Old Children.

    ERIC Educational Resources Information Center

    Balason, Denise V.; Dollaghan, Christine A.

    2002-01-01

    Grammatical morpheme (GM) production was studied in 15-minute spontaneous language samples from 100 4-year-olds. Substantial variability was observed in both the frequency of obligatory contexts and in the percentages of correct usage of GM. For only one morpheme did all 100 participants contain the minimum number of 3 obligatory contexts.…

  17. 20 CFR 210.4 - Year of service.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Year of service. 210.4 Section 210.4 Employees... SERVICE § 210.4 Year of service. (a) A year of service is twelve months of reported or deemed service, consecutive or not consecutive. A fraction of a year of service is taken at its actual value. (b) The...

  18. 20 CFR 210.4 - Year of service.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Year of service. 210.4 Section 210.4 Employees... SERVICE § 210.4 Year of service. (a) A year of service is twelve months of reported or deemed service, consecutive or not consecutive. A fraction of a year of service is taken at its actual value. (b) The...

  19. The OmegaWhite survey for short-period variable stars - I. Overview and first results

    NASA Astrophysics Data System (ADS)

    Macfarlane, S. A.; Toma, R.; Ramsay, G.; Groot, P. J.; Woudt, P. A.; Drew, J. E.; Barentsen, G.; Eislöffel, J.

    2015-11-01

    We present the goals, strategy and first results of the OmegaWhite survey: a wide-field high-cadence g-band synoptic survey which aims to unveil the Galactic population of short-period variable stars (with periods <80 min), including ultracompact binary star systems and stellar pulsators. The ultimate goal of OmegaWhite is to cover 400 deg2 along the Galactic plane reaching a depth of g = 21.5 mag (10σ), using OmegaCam on the VLT Survey Telescope (VST). The fields are selected to overlap with surveys such as the Galactic Bulge Survey and the VST Photometric Hα Survey of the Southern Galactic Plane for multiband colour information. Each field is observed using 38 exposures of 39 s each, with a median cadence of ˜2.7 min for a total duration of two hours. Within an initial 26 deg2, we have extracted the light curves of 1.6 million stars, and have identified 613 variable candidates which satisfy our selection criteria. Furthermore, we present the light curves and statistical properties of 20 sources which have the highest likelihood of being variable stars. One of these candidates exhibits the colours and light-curve properties typically associated with ultracompact AM CVn binaries, although its spectrum exhibits weak Balmer absorption lines and is thus not likely to be such a binary system. We also present follow-up spectroscopy of five other variable candidates, which identifies them as likely low-amplitude δ Sct pulsating stars.

  20. Hydrochemical monitoring results in relation to the vogtland-nw bohemian earthquake swarm period 2000

    NASA Astrophysics Data System (ADS)

    Kämpf, H.; Bräuer, K.; Dulski, P.; Faber, E.; Koch, U.; Mrlina, J.; Strauch, G.; Weise, S. M.

    2003-04-01

    The Vogtland-NW Bohemian earthquake swarm area/Central Europe is characterised by carbon dioxide- rich mineral springs and mofetts. The August-December 2000 earthquake period was the strongest compared with the December 1985/86 swarms occurred in the area of Novy Kostel, Czech Republic. Here, we present first results of long-term hydrochemical monitoring studies before, during and after the 2000 swarm period. The swarm 2000 lasted from August 28 until December 26 and consisted of altogether nine sub-swarm episodes, each of them lasting for several days. At the mineral spring Wettinquelle, Bad Brambach/Germany the water chemistry and isotope (D, 18O) composition was monitored weekly and two-weekly, respectively, since May 2000. The mineral spring Wettinquelle is located in a distance of about 10 km from the epicentral area of Novy Kostel. The aim of our investigation was to look for seismic induced or seismic coupled changes of the chemical and isotope composition of the mineral water. We had to separate seismohydrological effects from seasonal and hydrological caused changes. The seasonal caused shifts were found for water temperature and alkaline elements (Li, Na, K, Rb and Cs) as well as for discharge, conductivity, hydrogenecarbonate- concentration, and the concentration of the alkaline earth's (Ca, Mg, Sr). Strain related anomalies which could influence the hydrogeochemistry of the mineral water seems to be visible in the iron- concentration of the spring water, in the methane- concentration of the free gas component and caused probably changes of the groundwater level of the well H3 located about 5 km SE of the Wettinquelle at Skalna.

  1. Time periods of GSR particles deposition after discharge-final results.

    PubMed

    Fojtásek, Lubor; Kmjec, Tomás

    2005-10-29

    The elemental objects of the research study are: determination of time periods corresponding to gunshot residue particles (GSR) deposition after the shot from selected pistols and a revolver, and evaluation of the deposited particles number. For several shooting experiments were used a pistol CZ model 85, caliber 9 mm Luger with common ammunition 9 mm Luger FMJ Sellier & Bellot, a pistol CZ model 70, caliber 7.65 mm Browning (32 ACP) with common 7.65 mm Browning FMJ Sellier & Bellot ammunition and a revolver S&W Modell 60, barell length 2-1/8'', cal. .38 Special with common Sellier&Bellot (FMJ) ammunition. The results of the study have indicated the behavior of GSR particles deposited after a single discharge. The overall time interval of GSR particles deposition and the number of deposited particles with the above mentioned arms and ammunition were established. The results can potentially be used for clarifying the situation at crime scenes and for subsequent interpretation of GSR evidential value in caseworks. PMID:16139100

  2. Is There a Critical Period for Amblyopia Therapy? Results of a Study on Older Anisometropic Amblyopes

    PubMed Central

    2015-01-01

    Purpose Amblyopia, a common cause of low vision, is rarely treated in adults. Improvement in vision has been seen beyond the critical period at times. Hence, this study was taken up to study the effect of minimal occlusion therapy (2-4 hours/day) in anisometropic amblyopic patients in the age group of 12-30 years. Materials and Methods The study is a prospective, randomized case series of anisometropic amblyopia patients aged 12-30 years who reported in the outpatient department of Hakeem Abdul Hameed Centenary Hospital, New Delhi, from December 2011 to November 2013. Thorough ocular examination and cycloplegic refraction was done to rule out other ocular disease. Anisometropic Amblyopia was diagnosed only after four weeks of spectacle wear. The selected patients were then advised occlusion therapy of 2-4 hours per day of better eye with stress on near visual task. Videogames, computers, mobile phone gaming and colouring in especially designed patterns were used as vision training aids. The outcome measure selected was best corrected visual acuity (BCVA) achieved that remained stable for three consecutive months of occlusion. Results Sixty one patients of anisometropic amblyopia were included in the study (32 males and 29 females) aged 12-30 years (mean age 17 years). Mean BCVA at the start of treatment was 20/125 (0.8 log MAR units) and 20/32 (0.2 log MAR units) at the end of the treatment. Thirty three patients (54%) out of 61 had BCVA of 20/20, while 58 patients (95%) had ≥ 20/40 BCVA, 01(1.6%) had 20/50 and 02 (3.27%) had 20/80 BCVA at the end of therapy. The results were statistically significant (p- value <0.0001) with a 95% confidence interval. Conclusion This study clearly proves that there is no critical period for the treatment in older (12-30 years) anisometropic amblyope. Even 2-4 hours per day of occlusion of better eye with vision training thorough near visual task of amblyopic eye is effective. However, counseling and patient compliance is

  3. Retroperitoneal necrotizing fasciitis in a 4-year-old girl.

    PubMed

    Paya, K; Hayek, B F; Rebhandl, W; Pollak, A; Horcher, E

    1998-05-01

    Necrotizing fasciitis is a rare but serious condition with a poor prognosis both in adults and in children. Retroperitoneal localization is mostly associated with fatal outcome. Early diagnosis, extensive and repeated surgical debridement, and use of antibiotics are necessary. Herein the authors report on a 4-year-old girl in whom retroperitoneal necrotizing fasciitis developed after she suffered from pyelonephritis. In this case, the outcome was favorable because of early surgical intervention, confirming the diagnosis. PMID:9607500

  4. Obsessive Compulsive Disorder in a 4-Year-Old Child

    PubMed Central

    Kulkarni, Harish; Sudarshan, C. Y.

    2015-01-01

    Obsessive-compulsive disorder (OCD) is a very distressing disorder for both patient and caregiver. Usual onset of the disorder is in late second or early third decade of life. It is diagnosed in children but rarely before 5 years. A case of OCD in a 4-year-old girl is reported here. Diagnostic and therapeutic dilemmas in such a situation are discussed. PMID:25969614

  5. Are symptom features of depression during pregnancy, the postpartum period and outside the peripartum period distinct? Results from a nationally representative sample using Item Response Theory (IRT)

    PubMed Central

    Hoertel, Nicolas; López, Saioa; Peyre, Hugo; Wall, Melanie M.; González-Pinto, Ana; Limosin, Frédéric; Blanco, Carlos

    2014-01-01

    Background Whether there are systematic differences in depression symptom expression during pregnancy, the postpartum period and outside these periods (i.e., outside the peripartum period) remains debated. The aim of this study was to use methods based on item response theory (IRT) to examine, after equating for depression severity, differences in the likelihood of reporting DSM-IV symptoms of major depressive episode (MDE) in women of childbearing age (i.e., aged 18-50) during pregnancy, the postpartum period and outside the peripartum period. Method We conducted these analyses using a large, nationally representative sample of women of childbearing age from the USA (n = 11,256) who participated in the second wave of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Results The overall 12-month prevalence of all depressive criteria (except for worthlessness/guilt) was significantly lower in pregnant women than in women of childbearing age outside the peripartum period, whereas the prevalence of all symptoms (except for “psychomotor symptoms”) were not significantly different between the postpartum and the non-peripartum group. There were no clinically significant differences in the endorsement rates of symptoms of MDE by pregnancy status when equating for levels of depression severity. Conclusions This study suggests that the clinical presentation of depressive symptoms in women of childbearing age does not differ during pregnancy, the postpartum period and outside the peripartum period. These findings do not provide psychometric support for the inclusion of the peripartum onset specifier for major depressive disorder in the DSM-5. PMID:25424539

  6. STS-40 orbital acceleration research experiment flight results during a typical sleep period

    NASA Technical Reports Server (NTRS)

    Blanchard, R. C.; Nicholson, J. Y.; Ritter, J. R.

    1992-01-01

    The Orbital Acceleration Research Experiment (OARE), an electrostatic accelerometer package with complete on-orbit calibration capabilities, was flown for the first time aboard the Space Shuttle on STS-40. This is also the first time an accelerometer package with nano-g sensitivity and a calibration facility has flown aboard the Space Shuttle. The instrument is designed to measure and record the Space Shuttle aerodynamic acceleration environment from the free molecule flow regime through the rarified flow transition into the hypersonic continuum regime. Because of its sensitivity, the OARE instrument defects aerodynamic behavior of the Space Shuttle while in low-earth orbit. A 2-hour orbital time period on day seven of the mission, when the crew was asleep and other spacecraft activities were at a minimum, was examined. During the flight, a 'trimmed-mean' filter was used to produce high quality, low frequency data which was successfully stored aboard the Space Shuttle in the OARE data storage system. Initial review of the data indicated that, although the expected precision was achieved, some equipment problems occurred resulting in uncertain accuracy. An acceleration model which includes aerodynamic, gravity-gradient, and rotational effects was constructed and compared with flight data. Examination of the model with the flight data shows the instrument to be sensitive to all major expected low frequency acceleration phenomena; however, some erratic instrument bias behavior persists in two axes. In these axes, the OARE data can be made to match a comprehensive atmospheric-aerodynamic model by making bias adjustments and slight linear corrections for drift. The other axis does not exhibit these difficulties and gives good agreement with the acceleration model.

  7. Long Period Variables in the LMC: Results from MACHO and 2Mass

    SciTech Connect

    Fraser, O J; Cook, K H; Keller, S C; Hawley, S L

    2004-07-19

    We use the eight year light curve database from the MACHO (MAssive Compact Halo Objects) project together with infrared colors and magnitudes from 2MASS (the Two Micron All Sky Survey) to identify a sample of 22,000 long period variables in the Large Magellanic Cloud (referred to hereafter as LMC LPVs). A period luminosity diagram of these stars reveals six well defined sequences, in substantial agreement with previous analyses of samples from OGLE (Optical Gravitational Lensing Experiment). In our analysis we identify analogues to galactic LPVs in the LMC LPV sample. We find that carbon dominated AGB stars populate only two of the sequences, one of which includes the Mira variables. The high luminosity end of the same two sequences are also the location of the only stars with J K{sub s} > 2, indicating that they are enshrouded in dust. The unknown mechanism that produces the variability of the last sequence--those stars with long secondary periods--produces different morphology in the period luminosity diagram than what is seen in the first four sequences, which are thought to be caused by pulsation. In particular, the last sequence extends to lower luminosity RGB stars and the luminosity function does not peak among the AGB stars. We point out several features which will constrain new models of the period luminosity sequences.

  8. Isolation of Salmonella Enteritidis PT 30 from a single almond orchard over a 4-year period

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In 2001, Salmonella Enteritidis phage type (PT) 30 was isolated from drag swabs of 17 61-ha almond orchards on three farms linked to an outbreak of salmonellosis associated with consumption of raw almonds. The objective of this study was to evaluate the long-term persistence of Salmonella Enteritidi...

  9. Results of 5-year photometric monitoring of the intermediate polar V2306 Cygni: correction of the orbital period and evidence of 2-day periodicity

    NASA Astrophysics Data System (ADS)

    Breus, V.; Petrík, K.; Zoła, S.; Baransky, A.; Hegedus, T.

    2015-09-01

    We present the results of 6 years of photometric monitoring of the magnetic cataclysmic variable V2306 Cygni (formerly known as 1WGAJ1958.2+3232) obtained at collaborating observatories. Using (O-C) analysis we tried to study variability of the spin period of the white dwarf, however we cannot make a firm conclusion based on the scatter. Simultaneously, using (O-C) diagram of orbital minima, we found that the value of 0.181545(3) days better corresponds with the light curve, than do previously published orbital period values. We also found that the variability has a 2.01 day period; this variability may be interpreted as possible precession of the accretion disk in this system.

  10. Boundary conditions for creeping flow along periodic or random rough surfaces : experimental and theoretical results

    NASA Astrophysics Data System (ADS)

    Lecoq, Nicolas

    2012-12-01

    Hydrodynamic interactions between particles and walls are relevant for the open problem of specifying boundary conditions for suspension flows. The Reynolds number around a small particle close to a wall is usually low and creeping flow equations apply. From the solution of these equations, the drag coefficient on a sphere becomes infinite when the gap between the sphere and a smooth wall vanishes, so that contact may not occur. Physically, the drag is finite because of various reasons, one of them being the particle and wall roughness. Then, for vanishing gap, even though some layers of fluid molecules may be left between the particle and wall roughness peaks, it may conventionally be said that contact occurs. In this paper, we are considering the example of a smooth sphere moving towards a rough wall. The roughness considered here consist of random rough planes or parallel periodic wedges, the characteristic length of which is small compared with the sphere radius. This problem is considered both experimentally and theoretically. The motion of a millimetre size bead settling towards a corrugated horizontal wall in a viscous oil is measured with laser interferometry giving an accuracy on the displacement of 0.2μm. Several random rough planes and wedge shaped walls were used, with various wavelengths and wedge angles. From the results, it is observed that the velocity of the sphere is, except for small gaps, similar to that towards a smooth plane that is shifted down from the top of corrugations. For the periodic wedges, the creeping flow is calculated as a series in the slope of the roughness grooves. The convergence of the series for the shift distance in term of the slope is accelerated by use of Euler transformation and of the existence of a limit for large slope. The cases of a flow along and across the grooves are considered separately. The shift is larger in the former case. Slightly flattened tops of the wedges used in experiments are also considered in

  11. [Quality of results of therapy of acute respiratory failure : changes over a period of two decades].

    PubMed

    Briegel, I; Dolch, M; Irlbeck, M; Hauer, D; Kaufmann, I; Schelling, G

    2013-04-01

    Progress in intensive care (ICU) treatment of acute respiratory distress syndrome (ARDS) over the last 20 years includes the introduction of extracorporeal membrane oxygenation (ECMO) for CO2 removal and the widespread use of evidence-based lung-protective ventilatory strategies. Little is known, however, about whether these changes have resulted in improvements in short-term and long-term outcome of acute respiratory distress syndrome (ARDS) within the two decades after introduction. In a retrospective study 167 long-term survivors of severe ARDS who were transferred to the clinic for anesthesiology of the University of Munich, Campus Großhadern by means of specialized intensive care unit (ICU) transport teams and treated over a period of 20 years (1985-2005) were evaluated to investigate whether significant improvements in outcome as a consequence of the above mentioned progress in ARDS therapy have occurred. The ARDS patient cohort studied was characterized with regard to demographic variables, initial acute physiology and chronic health evaluation (APACHE) II score, duration of ICU treatment, the duration of mechanical ventilation and mortality. Data on long-term outcome were collected in a subcohort (n = 125) of patients who responded to mailed questionnaires and included health-related quality of life (HRQL, SF-36 questionnaire), symptoms of post-traumatic stress disorder (PTSD), traumatic memories from ICU treatment (PTSS-10 instrument) and current state of employment. During the observation period no significant changes regarding patient age (39 ± 16 years, mean ± SD), disease severity on admission to the ICU (APACHE II scores 22 ± 5), duration of ICU treatment (47 ± 39 days) or duration of mechanical ventilation (39 ± 38 days) were found. Overall ICU mortality during the two decades was 37.3 % (range 25.0 %-38.1 %) between 1995 and 2001 and a non-significant increase in values between 36.8 % and 58.3 % during the time interval from 2002 und 2005. The

  12. Herpes simplex virus hepatitis 4 years after liver transplantation.

    PubMed

    Bissig, Karl-Dimiter; Zimmermann, Arthur; Bernasch, Dirke; Furrer, Hansjakob; Dufour, Jean-FranCois

    2003-01-01

    If not promptly recognized and treated, herpes simplex virus (HSV) hepatitis is associated with a high mortality. A patient transplanted for primary sclerosing cholangitis required, 4 years later, a colectomy for a steroid-resistant flare of ulcerative colitis. He subsequently developed fever, with genital and oral ulcerations. He was hospitalized for diabetic decompensation with massive elevation of serum aminotransferases. Examination revealed vesicles on the hands. Liver biopsy showed Cowdry type B inclusions. Therapy with acyclovir was immediately initiated and the patient recovered. This case illustrates the diagnostic importance of mucocutaneous lesions in the assessment of complications after liver transplantation. PMID:14614611

  13. CULP (California Union List of Periodicals) 1980 User Survey Results. PN-77.

    ERIC Educational Resources Information Center

    Pearson, Karl M., Jr.

    This survey of California libraries was conducted to gather information on the use of the California Union List of Periodicals (CULP), a microfiche finding list for serials held in all kinds of libraries statewide, exept for those held by major academic institutions. Returned by 391 of 696 libraries in October 1980, the survey questionnaire was…

  14. Saturn's periodicities: New results from an MHD simulation of magnetospheric response to rotating ionospheric vortices

    NASA Astrophysics Data System (ADS)

    Kivelson, M.; Jia, X.

    2013-12-01

    In previous work we demonstrated that a magnetohydrodynamic (MHD) simulation of Saturn's magnetosphere in which periodicity is imposed by rotating vortical flows in the ionosphere reproduces many reported periodically varying properties of the system. Here we shall show that previously unreported features of the MHD simulation of Saturn's magnetosphere illuminate additional measured properties of the system. By averaging over a rotation period, we identify a global electric field whose magnitude is a few tenths of a mV/m (see Figure 1). The electric field intensity decreases with radial distance in the middle magnetosphere, consistent with drift speeds v=E/B of a few km/s towards the morning side and relatively independent of radial distance. The electric field within 10 RS in the equatorial plane is oriented from post-noon to post-midnight, in excellent agreement with observations [e.g., Thomsen et al., 2012; Andriopoulou et al., 2012, 2013; Wilson et al., 2013]. By following the electric field over a full rotation phase we identify oscillatory behavior whose magnitude is consistent with the reported fluctuations of measured electric fields. Of particular interest is the nature of the fast mode perturbations that produce periodic displacement of the magnetopause and flapping of the current sheet. Figure (2) shows the total perturbation pressure (the sum of magnetic and thermal pressure) in the equatorial plane at a rotation phase for which the ionospheric flow near noon is equatorward. By following the perturbations over a full rotation period, we demonstrate properties of the fast mode wave launched by the rotating flow structures and thereby characterize the 'cam' signal originally proposed by Espinosa et al. [2003].

  15. Fermi Large Area Telescope Operations: Progress Over 4 Years

    SciTech Connect

    Cameron, Robert A.; /SLAC

    2012-06-28

    The Fermi Gamma-ray Space Telescope was launched into orbit in June 2008, and is conducting a multi-year gamma-ray all-sky survey, using the main instrument on Fermi, the Large Area Telescope (LAT). Fermi began its science mission in August 2008, and has now been operating for almost 4 years. The SLAC National Accelerator Laboratory hosts the LAT Instrument Science Operations Center (ISOC), which supports the operation of the LAT in conjunction with the Mission Operations Center (MOC) and the Fermi Science Support Center (FSSC), both at NASA's Goddard Space Flight Center. The LAT has a continuous output data rate of about 1.5 Mbits per second, and data from the LAT are stored on Fermi and transmitted to the ground through TDRS and the MOC to the ISOC about 10 times per day. Several hundred computers at SLAC are used to process LAT data to perform event reconstruction, and gamma-ray photon data are subsequently delivered to the FSSC for public release with a few hours of being detected by the LAT. We summarize the current status of the LAT, and the evolution of the data processing and monitoring performed by the ISOC during the first 4 years of the Fermi mission, together with future plans for further changes to detected event data processing and instrument operations and monitoring.

  16. Inappropriate Neural Activity during a Sensitive Period in Embryogenesis Results in Persistent Seizure-like Behavior

    PubMed Central

    Giachello, Carlo N.G.; Baines, Richard A.

    2015-01-01

    Summary Maturation of neural circuits requires activity-dependent processes that underpin the emergence of appropriate behavior in the adult. It has been proposed that disruption of these events, during specific critical periods when they exert maximal influence, may lead to neurodevelopmental diseases, including epilepsy [1, 2, 3]. However, complexity of neurocircuitry, coupled with the lack of information on network formation in mammals, makes it difficult to directly investigate this hypothesis. Alternative models, including the fruit fly Drosophila melanogaster, show remarkable similarities between experimental seizure-like activity and clinical phenotypes [4, 5, 6]. In particular, a group of flies, termed bang-sensitive (bs) mutants have been extensively used to investigate the pathophysiological mechanisms underlying seizure [7, 8, 9, 10, 11, 12]. Seizure phenotype can be measured in larval stages using an electroshock assay, and this behavior in bs mutants is dramatically reduced following ingestion of typical anti-epileptic drugs (AEDs; [13]). In this study we describe a critical period of embryonic development in Drosophila during which manipulation of neural activity is sufficient to significantly influence seizure behavior at postembryonic stages. We show that inhibition of elevated activity, characteristic of bs seizure models, during the critical period is sufficient to suppress seizure. By contrast, increasing neuronal excitation during the same period in wild-type (WT) is sufficient to permanently induce a seizure behavior. Further, we show that induction of seizure in WT correlates with functional alteration of motoneuron inputs that is a characteristic of bs mutants. Induction of seizure is rescued by prior administration of AEDs, opening a new perspective for early drug intervention in the treatment of genetic epilepsy. PMID:26549258

  17. Spontaneous Analogical Transfer in 4-Year-Olds: A Microgenetic Study.

    ERIC Educational Resources Information Center

    Tunteler, Erika; Resing, Wilma C. M.

    2002-01-01

    This microgenetic experimental study examined children's spontaneous application of analogical problem solving from story problems to physical tasks. Results indicated that 4-year-olds did, with varying success, spontaneously apply analogical solutions to physical problems across sessions. A few children even gave an analogical strategy-related…

  18. Displacement reactions in the Ni-Al-O system resulting in periodic layer structures

    SciTech Connect

    Song, D.W.; Subramanian, R.; Dieckmann, R.

    1995-10-01

    Displacement reactions may play an important role in in situ processing technologies for the production of metal-ceramic composites. To better understand such reactions displacement reactions between NiO and Al were studied at high temperatures. Different reaction layers with periodic structures were observed involving Al{sub 2}O{sub 3}, Al{sub 3}Ni, Al{sub 3}Ni{sub 2}, Ni and Al. The experimental observations are presented and discussed with regard to the reaction mechanism.

  19. Experimental results of antigliadin antibodies detection using long period fiber grating

    NASA Astrophysics Data System (ADS)

    Corres, J. M.; Matias, I. R.; Goicoechea, J.; Arregui, F. J.; Viegas, D.; Araújo, F. M.; Santos, J. L.

    2008-04-01

    In this work a new nano-biofilm is proposed for the detection of celiac disease (CD). A long-period fiber grating (LPFG) is used as a transducer and the surface of the fiber is coated with a precursor layer of SiO2-nanospheres using the electrostatic self-assembly technique (ESA). This layer has been designed in order to create a substrate of high porosity where the gliadins could be deposited. Under the presence of specific antibodies antigliadin antibodies (AGA) the refractive index of the overlay changes giving a detectable shift in the resonance wavelength of the LPFG. Concentrations as low as 5 ppm were detected.

  20. Lateral resonances in 1{endash}3 piezoelectric periodic composite: Modeling and experimental results

    SciTech Connect

    Certon, D.; Patat, F.; Levassort, F.; Feuillard, G.; Karlsson, B.

    1997-04-01

    The objective of this work is to provide an accurate model of the lateral resonance modes in 1{endash}3 piezoelectric composite materials. These materials are widely used in ultrasonic transducers and the lowest lateral mode frequency gives the upper limit for the usable transducer bandwidth. Considering the propagation of purely transverse waves in a 2-D periodic medium of infinite thickness, two different approaches for obtaining the solutions are presented and compared. The first approach is based on the use of the Bloch waves theory. The second is a straightforward method (a so-called membrane method) which consists in numerically solving the propagation equation in the two-phase medium while taking into account the periodic boundary conditions. Methods based on both models are described that allow the calculation of the dispersion curves and the stop band limits, as well as the frequencies and the displacement fields of the lateral modes. A test case is used to compare and discuss the theoretical predictions provided by each model. The calculations of the first lateral mode frequency are compared with experimental values obtained for samples with different ceramic volume fractions. The conclusion reached indicates that the infinite thickness assumption is valid for plates of practical interest and that the membrane model enables the prediction of lateral mode frequency with low computation effort and an accuracy better than 5{percent}. {copyright} {ital 1997 Acoustical Society of America.}

  1. STS-40 orbital acceleration research experiment flight results during a typical sleep period

    NASA Technical Reports Server (NTRS)

    Blanchard, Robert C.; Nicholson, John Y.; Ritter, James R.

    1992-01-01

    The Orbital Acceleration Research Experiment (OARE), an electrostatic accelerometer package with complete on-orbit calibration capabilities was flown aboard Shuttle on STS-40. The instrument is designed to measure and record the Shuttle aerodynamic acceleration environment from the free molecule flow regime through the rarefied flow transition into the hypersonic continuum regime. Because of its sensitivity, the OARE instrument detects aerodynamic behavior of the Shuttle while in low-earth orbit. A 2-h orbital time period on day seven of the mission, when the crew was asleep and other spacecraft activities were at a minimum, was examined. Examination of the model with the flight data shows the instrument to be sensitive to all major expected low-frequency acceleration phenomena; however, some erratic instrument bias behavior persists in two axes. In these axes, the OARE data can be made to match a comprehensive atmospheric-aerodynamic model by making bias adjustments and slight liner corrections for drift.

  2. Lumbar disc replacement: preliminary results with ProDisc II after a minimum follow-up period of 1 year.

    PubMed

    Tropiano, Patrick; Huang, Russel C; Girardi, Federico P; Marnay, Thierry

    2003-08-01

    Total disc replacement has the potential to replace fusion as the gold standard surgical treatment of degenerative disc disease. Potential advantages of disc replacement over fusion include avoidance of pseudarthrosis, postoperative orthoses, and junctional degeneration. After observing satisfactory clinical results at 7-11 years' follow-up with the ProDisc first-generation implant, a second-generation prosthesis was designed. This study is a prospective analysis of the early results of total disc replacement with the ProDisc II total disc prosthesis. Fifty-three patients had single-level or multilevel disc replacement and were evaluated clinically and radiographically preoperatively and at mean 1.4-year follow-up. There were clinically and statistically significant improvements in back and leg pain Visual Analog Scale and Oswestry disability scores that were maintained at final follow-up. The clinical results of patients with single- and multilevel surgery were equivalent. Satisfactory results were achieved in 90% of patients who had previous lumbar surgery. Complications occurred in 9% of patients and included vertebral body fracture, transient radicular pain, implant malposition, and transient retrograde ejaculation. Three patients (6%) required reoperation to address complications. No mechanical failure of the implants or loosening was observed, and the prostheses retained motion. Randomized, prospective, long-term studies will be necessary to compare the effectiveness of arthrodesis with total disc replacement. PMID:12902952

  3. Increase in child behavior problems among urban Brazilian 4-year olds: 1993 and 2004 Pelotas birth cohorts

    PubMed Central

    Matijasevich, Alicia; Murray, Elizabeth; Stein, Alan; Anselmi, Luciana; Menezes, Ana M; Santos, Iná S; Barros, Aluísio JD; Gigante, Denise P; Barros, Fernando C; Victora, Cesar G

    2014-01-01

    Background There are an increasing number of reports on time trends in child and adolescent psychological problems but none from low- and middle-income countries, and very few covering the preschool period. The aim was to investigate changes in preschool behavioral/emotional problems in two birth cohorts from a middle-income country born 11 years apart. Methods We analyzed data from the 1993 and 2004 Pelotas birth cohort studies from Brazil. A subsample of 4-year olds from the 1993 cohort (634) and all 4-year olds from the 2004 cohort (3750) were assessed for behavioral/emotional problems through maternal report using the Child Behavior Checklist (CBCL). Response rates in these two population-based cohorts were above 90%. Results We found a significant increase in CBCL total problems, internalizing and externalizing mean scores over the 11-year period. For 1993 and 2004 Pelotas cohorts, respectively, CBCL mean values (SE) total problems scores were 27.9 (0.8) and 34.7 (0.3); for internalizing scores, 5.7 (0.2) and 6.3 (0.1) and for externalizing scores, 12.4 (0.4) and 15.5 (0.1). After adjusting for confounding variables, the largest increase from 1993 to 2004 was identified in the aggressive behavior syndrome score (Cohen's d = .50), followed by the externalizing problem score (Cohen's d = .40) and CBCL total problem score (Cohen's d = .36), respectively. The rise in child psychological problems was more marked in children from families with fewer assets and with less educated mothers. Conclusions Our findings provide evidence for a substantial increase in preschool behavioral problems among children in Brazil over an 11-year period. PMID:24735354

  4. Case Report: Traumatic anterior cerebral artery aneurysm in a 4-year old child

    PubMed Central

    Munakomi, Sunil; Tamrakar, Karuna; Chaudhary, Pramod; Bhattarai, Binod; Cherian, Iype

    2015-01-01

    Traumatic intracranial aneurysm in the proximal part of the anterior cerebral artery in the pediatric population has not been documented so far. Here we report the case of a 4 year-old child who developed a pseudo-aneurysm after minor head trauma and was managed successfully with trapping of the aneurysm. A ventriculo-peritoneal shunt was placed as the child became dependent on extraventricular drain during the post-operative period. The patient made excellent recovery in neurological status within 1 month of post-operative clinical follow up.

  5. Results of magnetic measurements of ELF fields in Tomsk for the period 2013-2014

    NASA Astrophysics Data System (ADS)

    Kolmakov, A. A.; Kolesnik, S. A.; Nedosekov, D. A.

    2015-11-01

    The paper describes a method of magnetic measurements of natural electromagnetic fields ELF range. The results of the analysis of the frequency characteristics of fashion Schumann resonances in a suburban area in the seasonally-daily cycle of observations.

  6. ALEXIS, the little satellite that could -- 4 years later

    SciTech Connect

    Roussel-Dupre, D.; Bloch, J.; Little, C.

    1997-10-01

    The 113-kg Array of Low Energy X-ray Imaging Sensors (ALEXIS) satellite was launched from the fourth flight of Pegasus on 25 April, 1993 into a 750 x 850 km, 70 degree inclination orbit. Due to damage sustained at the time of launch, ground controllers did not make contact with the satellite until late June. By late July, full satellite operations had been restored through the implementation of new procedures for attitude control. Science operations with the two onboard experiments began at that time. Now 4 years later is still collecting more than 100 MB of mission data per day. ALEXIS was originally designed to be a high risk, single string. {open_quotes}Smarter-Faster-Cheaper{close_quotes} satellite, with a 1 year nominal and a 3 year design limit. This paper will discuss how well the various satellite and experiment subsystems are surviving a variety of low and high radiation environments and what improvements have been made to make operations more autonomous. 11 refs., 2 figs., 2 tabs.

  7. [Influenza surveillance in five consecutive seasons during post pandemic period: results from National Influenza Center, Turkey].

    PubMed

    Altaş, Ayşe Başak; Bayrakdar, Fatma; Korukluoğlu, Gülay

    2016-07-01

    Influenza surveillance provides data about the characteristics of influenza activity, types, sub-types and antigenic properties of the influenza viruses in circulation in a region. Surveillance also provides for the preparation against potential influenza pandemics with the identification of the genetic properties of viruses and the mutant strains that could pose a threat. In this study, data in the scope of national influenza surveillance carried out by National Influenza Center, Turkey for five consecutive influenza seasons between 2010-2015, following the A(H1N1)pdm09 virus pandemic, have been presented and evaluated. A total of 15.149 respiratory samples, including 8.894 sentinel and 6.255 non-sentinel specimens, during 2010-2015 influenza seasons, within the periods between September and May, were evaluated in our center. All samples were tested using real-time reverse transcriptase PCR (rRT-PCR) for the presence of influenza virus types and subtypes. Within the sentinel influenza surveillance, the samples that were detected negative for influenza viruses, have also been tested for the other respiratory viruses (respiratory syncytial virus, rhinoviruses, paramyxoviruses, coronaviruses) using the same technique. Further analysis, including virus isolation by cell culture inoculation and antigenic characterization by hemagglutination inhibiton test were performed for the samples found positive for influenza A and B viruses. Selected representative virus isolates have been sent to WHO reference laboratory for the sequence analysis. In the study, influenza virus positivity rates detected for all of the samples (sentinel+non-sentinel) were as follows; 34% (779/2316) in 2010-11 season; 25% (388/1554) in 2011-12; 20% (696/3541) in 2012-13; 23% (615/2678) in 2013-14; and 26% (1332/5060) in 2014-15. When all the samples were considered for influenza A and B viruses, the positivity rates for the seasons of 2010-11; 2011-12; 2012-13; 2013-14; 2014-15 were determined as

  8. Amphetamines and cannabinoids testing in hair: Evaluation of results from a two-year period.

    PubMed

    Burgueño, María José; Alonso, Amaya; Sánchez, Sergio

    2016-08-01

    This paper presents an overview of a set of amphetamines and cannabinoids tests performed on head hair samples from the Medico-Legal sector at the Madrid Department of the Spanish National Institute of Toxicology and Forensic Sciences during the years 2013 and 2014. The hair samples were tested for five stimulant phenylalkylamine derivatives -amphetamine (AP), methamphetamine (MA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxy-amphetamine (MDA), and 3,4-methylenedioxy-N-ethylamphetamine (MDEA)- and/or two cannabinoids-Δ(9)-tetrahydrocannabinol (THC) and cannabinol (CBN)- by gas chromatography equipped with mass spectrometry detection in selected-ion monitoring mode, applying a method accredited to ISO/IEC 17025 standards. The test results were interpreted according to the confirmation cut-offs proposed by the Society of Hair Testing (SoHT) to identify chronic drug use. The ratios of positive results were studied in relation to gender, age, hair colour, dyeing and length of the tested samples to assess the independence from these variables or the association with them. Low, medium and high ranges of concentration were also estimated for each drug. 21.94% of the 2954 hair samples tested for phenylalkylamine derivatives were positive for one or more substances. 16.38% of the samples were positive for AP, 12.09% for MDMA and only 0.44% for MA. 6.60% of the tested samples were positive for AP/MDMA combination. A total of 3178 samples were tested for cannabinoids, resulting in 53.40% positive for THC and CBN. Simultaneous tests for phenylalkylamine derivatives and cannabinoids were performed in 2931 of the samples; 14.94% of them were positive for THC, CBN, and one or more amphetamines. According to the results from the statistical analysis, the use of THC and MDMA vary with age and gender among the Medico-Legal sector in an extended area of Spain, while the use of AP appears to be independent of these variables. On the other hand, the results of THC in

  9. The National Practitioner Data Bank: the first 4 years.

    PubMed

    Oshel, R E; Croft, T; Rodak, J

    1995-01-01

    The National Practitioner Data Bank became operational September 1, 1990, as a flagging system to identify health care practitioners who may have been involved in incidents of medical incompetence. Query volumes have grown substantially over the Data Bank's first 4 years of operation. The greatest increase has come in the number of voluntary queries. By the end of 1994, the Data Bank had processed more than 4.5 million requests for information on practitioners, more than 1.5 million of which were received in 1994 alone. The proportion of queries for which the Data Bank contains information on the practitioner in question has grown as the Data Bank has come to contain more reports. During 1994, 7.9 percent of queries were matched. The Data Bank contained more than 97,500 reports at the end of 1994. More than 82 percent of the reports concerned malpractice payments. Licensure reports made up the bulk of the rest. Physicians predominate in reports, accounting for slightly more than 76 percent of the total. The remainder are related to dentists (16 percent) and all other types of practitioners (8 percent). Since reporting of adverse actions is mandatory only for physicians and dentists, the proportion of reports attributable to these types of practitioners is higher than it would be if adverse action reporting requirements were uniform for all practitioners. State malpractice payment rates and adverse action rates vary widely, but a State's rate in any given year is highly correlated with its rate in any other year. State malpractice rates are not strongly correlated with adverse action rates, neither are the rates for physicians strongly correlated with those for dentists. There is a weak tendency for States with smaller physician populations to have higher levels of licensure and privileging actions. PMID:7638325

  10. Reductions in Serum Lipids with a 4-year Decline in Serum Perfluorooctanoic Acid and Perfluorooctanesulfonic Acid

    PubMed Central

    Fitz-Simon, Nicola; Fletcher, Tony; Luster, Michael I.; Steenland, Kyle; Calafat, Antonia M.; Kato, Kayoko; Armstrong, Ben

    2016-01-01

    Background Several epidemiological cross-sectional studies have found positive associations between serum concentrations of lipids and perfluorooctanoic acid (PFOA, or C8). A longitudinal study should be less susceptible to biases from uncontrolled confounding or reverse causality. Methods We investigated the association between within-individual changes in serum PFOA and perfluorooctanesulfonic acid (PFOS) and changes in serum lipid levels (low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol, total cholesterol, and triglycerides) over a 4.4-year period. The study population consisted of 560 adults living in parts of Ohio and West Virginia where public drinking water had been contaminated with PFOA. They had participated in a cross-sectional study in 2005–2006, and were followed up in 2010, by which time exposure to PFOA had been substantially reduced. Results Overall serum concentrations of PFOA and PFOS fell by half from initial geometric means of 74.8 and 18.5 ng/mL, respectively, with little corresponding change in LDL cholesterol (mean increase 1.8%, standard deviation 26.6%). However, there was a tendency for people with greater declines in serum PFOA or PFOS to have greater LDL decrease. For a person whose serum PFOA fell by half, the predicted fall in LDL cholesterol was 3.6% (95% confidence interval = 1.5–5.7%). The association with a decline in PFOS was even stronger, with a 5% decrease in LDL (2.5–7.4%). Conclusions Our findings from this longitudinal study support previous evidence from cross-sectional studies of positive associations between PFOA and PFOS in serum and LDL cholesterol. PMID:23685825

  11. Changes in Smoking Prevalence, Attitudes, and Beliefs over 4 Years Following a Campus-Wide Anti-Tobacco Intervention

    ERIC Educational Resources Information Center

    Lechner, William V.; Meier, Ellen; Miller, Mary Beth; Wiener, Josh L.; Fils-Aime, Yvon

    2012-01-01

    Objective: The current study examined the effectiveness of an institutional intervention aimed at decreasing prevalence of tobacco use and exposure to smoke on campus over a 4-year period. Participants: Participants were undergraduate students (N = 4,947) enrolled at a large Midwestern university between 2007 and 2010. Methods: In 2008, tobacco…

  12. Design and Experimental Results for the S825 Airfoil; Period of Performance: 1998-1999

    SciTech Connect

    Somers, D. M.

    2005-01-01

    A 17%-thick, natural-laminar-flow airfoil, the S825, for the 75% blade radial station of 20- to 40-meter, variable-speed and variable-pitch (toward feather), horizontal-axis wind turbines has been designed and analyzed theoretically and verified experimentally in the NASA Langley Low-Turbulence Pressure Tunnel. The two primary objectives of high maximum lift, relatively insensitive to roughness and low-profile drag have been achieved. The airfoil exhibits a rapid, trailing-edge stall, which does not meet the design goal of a docile stall. The constraints on the pitching moment and the airfoil thickness have been satisfied. Comparisons of the theoretical and experimental results generally show good agreement.

  13. Design and Experimental Results for the S827 Airfoil; Period of Performance: 1998--1999

    SciTech Connect

    Somers, D. M.

    2005-01-01

    A 21%-thick, natural-laminar-flow airfoil, the S827, for the 75% blade radial station of 40- to 50-meter, stall-regulated, horizontal-axis wind turbines has been designed and analyzed theoretically and verified experimentally in the NASA Langley Low-Turbulence Pressure Tunnel. The primary objective of restrained maximum lift has not been achieved, although the maximum lift is relatively insensitive to roughness, which meets the design goal. The airfoil exhibits a relatively docile stall, which meets the design goal. The primary objective of low profile drag has been achieved. The constraints on the pitching moment and the airfoil thickness have been satisfied. Comparisons of the theoretical and experimental results generally show good agreement with the exception of maximum lift, which is significantly underpredicted.

  14. A new paleointensity result deduced for the Oligocene period fromQatrani basalt, Egypt

    NASA Astrophysics Data System (ADS)

    Saleh, Ahmed; Yamamoto, Yuhji

    2016-04-01

    We have conducted paleodirection and paleointensity measurements of basalt flows from Qatrani basalt, Egypt. Published age of Qatrani basat is 25±2 Ma. Various rock magnetic analyses indicate that the main magnetic carriers of samples are one phase of pure magnetite (Ti-poor titanomagnetites), which have pseudo single domain (PSD) sizes. Directional analysis of the Oligocene basalts is very straightforward and updated mean VGPs have been calculated from the Qatrani (68N, 90E; Kappa=274; A95=1.8) which is coincide with the previous Oligocene paleomagnetic studies. The Tsunakawa-Shaw (LTD-DHT Shaw) method yielded five successful results of 12.9-17.5 μTfrom two sites, giving one acceptable site-mean paleointensityof 15.5 μT with a standard deviation of 1.8 μTat the 25±2Ma. In terms of a dipole moment, an average VDM is calculated to be 2.7×1022A m2with a standard deviation of 1.29×1022Am2. This is the first result from Egypt, and is associated with a reasonably high QPI value (Biggin and Paterson, 2015) of 5. The newly obtained VDM is indistinguishable from an average VDM of 3.55×1022Am2with a standard deviation of 0.67×1022Am2 calculated from theselected 65 site-mean Thellier paleointensity data from the latest paleointensity database, and is about third of the present geomagnetic dipole moment (˜8×1022 Am2).

  15. Clinical and functional results after the rehabilitation period in minimally-invasive unicondylar knee arthroplasty patients.

    PubMed

    Fuchs, Susanne; Rolauffs, Bernd; Plaumann, Thorsten; Tibesku, Carsten O; Rosenbaum, Dieter

    2005-04-01

    The objective of the present study was to analyze the clinical and functional outcome after minimally-invasive implantation of a Repicci-type unicompartmental sledge prosthesis . In 29 patients with primary unicompartmental knee osteoarthritis, 29 replacements of the medial compartment and four of the lateral compartment were performed using the minimally-invasive technique with the metal-backed and the all-polyethylene versions of the Repicci sledge prosthesis. Electromyography (EMG) of standardized locations was measured with the MyoSystem 2000 and analyzed with Myoresearch software. Gait analysis was performed with a six-camera motion analysis system and force platforms. Established clinical and quality of life (SF-36) scores were used to compare patients with 11 healthy age-matched individuals. The Repicci sledge prosthesis led postoperatively to functional results that were in the range of healthy joints, and superior to sledge prostheses of a different design. Gait and balance parameters were comparable to the control group, whilst electromyographically lower amplitudes were found in the patients than the controls and in the operated legs as compared to the non-operated legs. Many parameters of quality of life and activity were comparable to age-matched healthy individuals, and quality of life was superior to total knee replacement. When implanted using a minimally-invasive technique and with suitable patient selection, the Repicci sledge led to functional results comparable to those of healthy joints and gait parameters comparable to those of healthy individuals. The level of evidence is Level III, retrospective cohort study. PMID:15175850

  16. Long-term quasi-periodicity of 4U 1636-536 resulting from accretion disc instability

    NASA Astrophysics Data System (ADS)

    Wisniewicz, Mateusz; Zdziarski, Andrzej; Janiuk, Agnieszka; Rosinska, Dorota; Slowikowska, Agnieszka

    2016-07-01

    We present the results of a study of the low-mass X-ray binary 4U 1636-536. We have performed temporal analysis of all available RXTE/ASM, RXTE/PCA, Swift/BAT and MAXI data. We have confirmed the previously discovered quasi-periodicity of ˜45 d present during ˜2004, however we found it continued to 2006. At other epochs, the quasi-periodicity is only transient, and the quasi-period, if present, drifts. We have then applied a time-dependent accretion disc model to the interval with the significant X-ray quasi-periodicity. For our best model, the period and the amplitude of the theoretical light curve agree well with that observed. The modelled quasi-periodicity is due to the hydrogen thermal-ionization instability occurring in outer regions of the accretion disc. The model parameters are the average mass accretion rate (estimated from the light curves), and the accretion disc viscosity parameters, α_{cold} and α_{hot}, for the hot and cold phases, respectively. Our best model gives relatively low values of α_{cold} and α_{hot}.

  17. Surgical Treatment of a 4-Year-Old Child with Hypertrophic Obstructive Cardiomyopathy: Case Report.

    PubMed

    Chen, Jin; Wu, Qingyu; Xu, Zhonghua; Kong, Xiangchen

    2016-01-01

    The incidence of pediatric hypertrophic obstructive cardiomyopathy is low. The lesions usually involve the left ventricle or ventricular septum, leading to either left or right ventricular outflow tract stenosis. However, combined left and right ventricular outflow tract stenosis is rare, and the surgical treatment is limited, especially in children. Surgery to release the obstruction was performed successfully in a 4-year-old child with right and left ventricular outflow tract obstruction together with a hypertrophic cardiomyopathy. The result was excellent. PMID:26913685

  18. CO2 fluxes exchanged by a 4-year crop rotation cycle.

    NASA Astrophysics Data System (ADS)

    Aubinet, M.; Moureaux, C.; Bodson, B.; Dufranne, D.; Heinesch, B.; Suleau, M.; Vancutsem, F.; Vilret, A.

    2009-04-01

    This study analyses carbon fluxes exchanged by a production crop during a four year cycle. Between 2004 and 2008, the successive crops were sugar beet, winter wheat, potato and again winter wheat. Eddy covariance, automatic and manual soil chamber, leaf diffusion and biomass measurements were performed continuously in order to obtain the daily and seasonal Net Ecosystem Exchange (NEE), Gross Primary Productivity (GPP), Total Ecosystem Respiration (TER), Net Primary Productivity (NPP), Autotrophic Respiration, Heterotrophic Respiration and Net Biome Production (NBP). The whole cycle budget showed that NEE was negative and the rotation behaved as a sink of 1.59 kgC m-2 over the 4-year rotation. However, if exports were deducted from the budget, the crop would become a small source of 0.22 (+/- 0.14) kgC m-2, which also suggests that the crop soil carbon content decreased. This could partly be explained by the crop management, as neither farmyard manure nor slurry had been applied to the crop for more than 10 years and as cereal straw had been systematically exported for livestock. This result is also strongly dependent on climate: the fluxes were subjected to a large inter-annual variability due to differences between crops but also to climate variability. In particular, the mild winter and the dry spring underwent in 2007 induced an increase of the biomass fraction that returned to the soil, at the expense of harvested biomass. If 2007 had been a ‘normal' year, the carbon emission by the crop rotation would have been twice as great. This is analysed more in detail in a companion presentation (Dufranne et al., this session). The impacts of some farmer interventions were quantified. In particular, the impact of ploughing was found to be limited both in intensity (1 to 2 micromol m-2 s-1) and duration (not more than 1 day). Seasonal budgets showed that, during cropping periods, the TER/GPP ratio varied between 40 and 60% and that TER was dominated mainly by the

  19. 42 CFR 476.96 - Review period and reopening of initial denial determinations and changes as a result of DRG...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Review period and reopening of initial denial determinations and changes as a result of DRG validations. 476.96 Section 476.96 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS UTILIZATION AND QUALITY...

  20. 42 CFR 476.96 - Review period and reopening of initial denial determinations and changes as a result of DRG...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Review period and reopening of initial denial determinations and changes as a result of DRG validations. 476.96 Section 476.96 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS QUALITY IMPROVEMENT...

  1. Prosthetic Rehabilitation of a Patient with Gastroesophageal Reflux Disease: 4-Year Followup

    PubMed Central

    Okida, Ricardo Coelho; dos Santos, Daniela Micheline; Vechiato Filho, Aljomar José; Andreotti, Agda Marobo; de Medeiros, Rodrigo Antonio; Goiato, Marcelo Coelho

    2014-01-01

    The gastroesophageal reflux disease (GERD) is one of the main causes of dental erosion. The aim of this case presented is to describe the prosthetic rehabilitation of a patient with GERD after 4 years of followup. A 33-year-old male patient complained about tooth sensitivity. The lingual surface of the maxillary anterior teeth and the cusps of the upper and lower posterior teeth presented wear. It was suspected that the feeling of heartburn reported by the patient associated with the intake of sports supplements (isotonics) was causing gastroesophageal changes. The patient was referred to a gastroenterologist and was diagnosed with GERD. Dental treatment was performed with metal-free crowns and porcelain veneers after medical treatment of the disease. With the change in eating habits, the treatment of GERD and lithium disilicate ceramics provided excellent cosmetic results after 4 years and the patient reported satisfaction with the treatment. PMID:24715992

  2. The HyMeX Special Observation Period in Central Italy: precipitation measurements, retrieval techniques and preliminary results

    NASA Astrophysics Data System (ADS)

    Silvio Marzano, Frank; Baldini, Luca; Picciotti, Errico; Colantonio, Matteo; Barbieri, Stefano; Di Fabio, Saverio; Montopoli, Mario; Vulpiani, Gianfranco; Roberto, Nicoletta; Adirosi, Elisa; Gorgucci, Eugenio; Anagnostou, Marios N.; Kalogiros, John; Anagnostou, Emmanouil N.; Ferretti, Rossella; Gatlin, Patrick.; Wingo, Matt; Petersen, Walt

    2013-04-01

    The Mediterranean area concentrates the major natural risks related to the water cycle, including heavy precipitation and flash-flooding during the fall season. The capability to predict such high-impact events remains weak because of the contribution of very fine-scale processes and their non-linear interactions with the larger scale processes. These societal and science issues motivate the HyMeX (Hydrological cycle in the Mediterranean Experiment, http://www.hymex.org/) experimental programme. HyMeX aims at a better quantification and understanding of the water cycle in the Mediterranean with emphasis on intense events. The observation strategy of HyMEX is organized in a long-term (4 years) Enhanced Observation Periods (EOP) and short-term (2 months) Special Observation Periods (SOP). HyMEX has identified 3 main Mediterranean target areas: North-West (NW), Adriatic (A) and South-East (SE). Within each target area several hydrometeorological sites for heavy rainfall and flash flooding have been set up. The hydrometeorological site in Central Italy (CI) is interested by both western and eastern fronts coming from the Atlantic Ocean and Siberia, respectively. Orographic precipitations play an important role due to the central Apennine range, which reaches nearly 3000 m (Gran Sasso peak). Moreover, convective systems commonly develop in CI during late summer and beginning of autumn, often causing localized hailstorms with cluster organized cells. Western fronts may heavily hit the Tiber basin crossing large urban areas (Rome), whereas eastern fronts can cause flash floods along the Adriatic coastline. Two major basins are involved within CI region: Tiber basin (1000 km long) and its tributary Aniene and the Aterno-Pescara basin (300 km long). The first HyMeX SOP1.1 was carried out from Sept. till Nov. 2012 in the NW target area. The Italian SOP1.1 was coordinated by the Centre of Excellence CETEMPS, University of L'Aquila, a city located in the CI heart. The CI area

  3. The HyMeX Special Observation Period in Central Italy: Precipitation Measurements, Retrieval Techniques and Preliminary Results

    NASA Technical Reports Server (NTRS)

    Gatlin, Patrick; Wingo, Matt; Petersen, Walt; Marzano, Frank Silvio; Baldini, Luca; Picciotti, Errico; Colantonio, Matteo; Barbieri, Stefano; Di Fabio, Saverio; Montopoli, Mario; Roberto, Nicoletta; Adirosi, Elisa; Gorgucci, Eugenio; Anagnostou, Emmanoil N..; Ferretti, Rossella

    2013-01-01

    The Mediterranean area concentrates the major natural risks related to the water cycle, including heavy precipitation and flash-flooding during the fall season. The capability to predict such high-impact events remains weak because of the contribution of very fine-scale processes and their non-linear interactions with the larger scale processes. These societal and science issues motivate the HyMeX (Hydrological cycle in the Mediterranean Experiment, http://www.hymex.orgl) experimental programme. HyMeX aims at a better quantification and understanding of the water cycle in the Mediterranean with emphasis on intense events. The observation strategy of HyMEX is organized in a long-term (4 years) Enhanced Observation Periods (EOP) and short-term (2 months) Special Observation Periods (SOP). HyMEX has identified 3 main Mediterranean target areas: North-West (NW), Adriatic (A) and South-East (SE). Within each target area several hydrometeorological sites for heavy rainfall and flash flooding have been set up. The hydrometeorological sire in Central Italy (CI) is interested by both western and eastern fronts coming from the Atlantic Ocean and Siberia, respectively. Orographic precipitations play an important role due to the central Apennine range, which reaches nearly 3000 m (Gran Sasso peak). Moreover, convective systems commonly develop in CI during late summer and beginning of autumn, often causing localized hailstorms with cluster organized cells. Western fronts may heavily hit the Tiber basin crossing large urban areas (Rome), whereas eastern fronts can cause flash floods along the Adriatic coastline. Two major basins are involved within Cl region: Tiber basin (1000 km long) and its tributary Aniene and the Aterno-Pescara basin (300 km long). The first HyMeX SOP1.1 was carried out from Sept. till Nov. 2012 in the NW target area The Italian SOP1.1 was coordinated by the Centre of Excellence CETEMPS, University of L'Aquila, a city located in the CI heart. The CI area

  4. A 4-year investigation into phonetic inventory development in young cochlear implant users.

    PubMed

    Serry, T A; Blamey, P J

    1999-02-01

    Phonetic inventories of 9 children with profoundly impaired hearing who used the 22-electrode cochlear implant (Cochlear Limited) were monitored before implantation and during the first 4 years of implant use. All children were 5 years old or younger at the time of implant. Spontaneous speech samples were collected at regular intervals for each child and analyzed to investigate phone acquisition over the post-implant period. Acquisition was measured using two different criteria. The "targetless" criterion required the child to produce a phonetically recognizable sound spontaneously, and the "target" criterion required the child to produce the phone correctly at least 50% of the time in meaningful words. At 4 years post-implant, 40 out of 44 phones (91 %) had reached the targetless criterion, and 29 phones (66%) had reached the target criterion for 5 or more of the children. Over the time of the study 100% of monophthongs, 63% of diphthongs, and 54% of consonants reached the target criterion. The average time taken for a phone to progress from the targetless to target criterion was 15 months. Overall, the data suggest trends in the order of phone acquisition similar to those of normally hearing children, although the process of acquisition occurred at a slower rate. PMID:10025550

  5. The 4 year stability of psychopathic traits in non-referred youth.

    PubMed

    Frick, Paul J; Kimonis, Eva R; Dandreaux, Danielle M; Farell, Jamie M

    2003-01-01

    One significant limitation in research extending the construct of psychopathy to youth has been the absence of longitudinal studies testing the stability of psychopathic traits prior to adulthood. To begin to address this limitation, the current study estimated the stability of psychopathic traits over a 4 year period in a sample of non-referred children in the third, fourth, sixth, and seventh grades at the first assessment. For parent ratings of psychopathic traits, stability estimates using intra-class correlation coefficients ranged from 0.80 to 0.88 across 2-4 years, with a stability estimate of 0.93 across all four assessments. There were also distinct trends in the patterns of stability found in the sample. Specifically, children rated as being initially high on these traits were more likely to be rated lower at later assessments than was the case for children rated initially low on these traits. Finally, the child's level of conduct problems, the socioeconomic status of the child's family, and the quality of parenting the child received were the most consistent predictors of stability of psychopathic traits. PMID:14696028

  6. Ultra-short-period Planets in K2 SuPerPiG Results for Campaigns 0–5

    NASA Astrophysics Data System (ADS)

    Adams, Elisabeth R.; Jackson, Brian; Endl, Michael

    2016-08-01

    We analyzed data from Campaigns 0–5 of the K2 mission and report 19 ultra-short-period candidate planets with orbital periods of less than one day (nine of which have not been previously reported). Planet candidates range in size from 0.7 to 16 Earth radii and in orbital period from 4.2 to 23.5 hr. One candidate (EPIC 203533312, Kp = 12.5) is among the shortest-period planet candidates discovered to date (P=4.2 hr), and, if confirmed as a planet, must have a density of at least ρ =8.9 {{g}} {{cm}}-3 to not be tidally disrupted. Five candidates have nominal radius values in the sub-Jovian desert ({R}P=3{--}11 {R}\\oplus and P≤slant 1.5 days) where theoretical models do not favor their long-term stability; the only confirmed planet in this range is thought to be disintegrating (EPIC 201637175). In addition to the planet candidates, we report on four objects that may not be planetary, including one with intermittent transits (EPIC 211152484) and three initially promising candidates that are likely false positives based on characteristics of their light curves and on radial velocity follow-up. A list of 91 suspected eclipsing binaries identified at various stages in our vetting process is also provided. Based on an assessment of our survey's completeness, we estimate an occurrence rate for ultra-short-period planets among K2 target stars that is about half that estimated from the Kepler sample, raising questions as to whether K2 systems are intrinsically different from Kepler systems, possibly as a result of their different galactic location.

  7. [Fentanyl in peridural obstetrical analgesia. Evaluation after 4 years' use].

    PubMed

    Lévêque, C; Garen, C; Pathier, D; Mazuir, E; Maneglia, R; Janse-Marec, J; Cousin, M T

    1987-01-01

    7,500 deliveries occurred from the date of opening of the Maternity Hospital Jean-Rostand. 3,500 of these were conducted under epidural anaesthesia. At different stages prospective studies were carried out to recall the effect of adding fentanyl to bupivacaine when the epidural injection was made. A pharmacokinetic study. This shows that the levels in the mother and the fetus begin to coincide more with the number of doses that are given and pass from 0.3 after 50 micrograms have been administered to 0.5 after 100 micrograms have been administered and 0.7 after 150 micrograms have been administered. The fetal levels are far lower than those required to depress respiration. The half life of distribution through the circulation has been worked out at 4 minutes and the half for elimination of the drug at 460 minutes. The maternal levels show great fluctuations and late alterations. Analgesia is earlier, more complete and more prolonged when fentanyl is added. Fentanyl also masks irregularities. Undesirable effects such as tiredness, pruritus, nausea, vomiting and urinary retention occur infrequently and last only for short periods of time. No mother had respiratory depression. The doses of bupivacaine that had to be given were as a whole less when fentanyl was added. In 40% of cases it only required one injection to achieve analgesia throughout the whole labour. The length of labour and the number of caesarean operations carried out did not change.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3584862

  8. Building the European Seismological Research Infrastructure: results from 4 years NERIES EC project

    NASA Astrophysics Data System (ADS)

    van Eck, T.; Giardini, D.

    2010-12-01

    The EC Research Infrastructure (RI) project, Network of Research Infrastructures for European Seismology (NERIES), implemented a comprehensive European integrated RI for earthquake seismological data that is scalable and sustainable. NERIES opened a significant amount of additional seismological data, integrated different distributed data archives, implemented and produced advanced analysis tools and advanced software packages and tools. A single seismic data portal provides a single access point and overview for European seismological data available for the earth science research community. Additional data access tools and sites have been implemented to meet user and robustness requirements, notably those at the EMSC and ORFEUS. The datasets compiled in NERIES and available through the portal include among others: - The expanded Virtual European Broadband Seismic Network (VEBSN) with real-time access to more then 500 stations from > 53 observatories. This data is continuously monitored, quality controlled and archived in the European Integrated Distributed waveform Archive (EIDA). - A unique integration of acceleration datasets from seven networks in seven European or associated countries centrally accessible in a homogeneous format, thus forming the core comprehensive European acceleration database. Standardized parameter analysis and actual software are included in the database. - A Distributed Archive of Historical Earthquake Data (AHEAD) for research purposes, containing among others a comprehensive European Macroseismic Database and Earthquake Catalogue (1000 - 1963, M ≥5.8), including analysis tools. - Data from 3 one year OBS deployments at three sites, Atlantic, Ionian and Ligurian Sea within the general SEED format, thus creating the core integrated data base for ocean, sea and land based seismological observatories. Tools to facilitate analysis and data mining of the RI datasets are: - A comprehensive set of European seismological velocity reference model including a standardized model description with several visualisation tools currently adapted on a global scale. - An integrated approach to seismic hazard modelling and forecasting, a community accepted forecasting testing and model validation approach and the core hazard portal developed along the same technologies as the NERIES data portal. - Implemented homogeneous shakemap estimation tools at several large European observatories and a complementary new loss estimation software tool. - A comprehensive set of new techniques for geotechnical site characterization with relevant software packages documented and maintained (www.geopsy.org). - A set of software packages for data mining, data reduction, data exchange and information management in seismology as research and observatory analysis tools NERIES has a long-term impact and is coordinated with related US initiatives IRIS and EarthScope. The follow-up EC project of NERIES, NERA (2010 - 2014), is funded and will integrate the seismological and the earthquake engineering infrastructures. NERIES further provided the proof of concept for the ESFRI2008 initiative: the European Plate Observing System (EPOS). Its preparatory phase (2010 - 2014) is also funded by the EC.

  9. Metabolic Health Is More Important than Obesity in the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Retrospective Study

    PubMed Central

    Lee, Min-Kyung; Rhee, Eun-Jung; Kim, Min Chul; Moon, Byung Sub; Lee, Jeong In; Song, Young Seok; Han, Eun Na; Lee, Hyo Sun; Son, Yoonjeong; Park, Se Eun; Park, Cheol-Young; Oh, Ki-Won; Park, Sung-Woo

    2015-01-01

    Background The aim of this study is to compare the risk for future development of nonalcoholic fatty liver disease (NAFLD) according to different status of metabolic health and obesity. Methods A total of 3,045 subjects without NAFLD and diabetes at baseline were followed for 4 years. Subjects were categorized into four groups according to the following baseline metabolic health and obesity statuses: metabolically healthy, non-obese (MHNO); metabolically healthy, obese (MHO); metabolically unhealthy, non-obese (MUHNO); and metabolically unhealthy, obese (MUHO). Being metabolically healthy was defined as having fewer than two of the following five components: high blood pressure, high fasting blood glucose, high triglyceride, low high density lipoprotein cholesterol, and being in the highest decile of the homeostasis model assessment-insulin resistance index. Obesity was defined as a body mass index >25 kg/m2. The presence of NAFLD was assessed by ultrasonography. Results The proportions of subjects included in the MHNO, MHO, MUHNO, and MUHO groups were 71.4%, 9.8%, 13.0%, and 5.8%, respectively. The proportions of subjects who developed NAFLD were 10.5%, 31.4%, 23.2%, and 42% in the MHNO, MHO, MUHNO, and MUHO groups, respectively. The risk for developing NAFLD was highest in subjects who were metabolically unhealthy both at baseline and after 4 years compared with subjects who were consistently metabolically healthy during the follow-up period (odds ratio, 2.862). Using the MHNO group as reference, the odds ratios for the MHO, MUHNO, and MUHO groups were 1.731, 1.877, and 2.501, respectively. Conclusion The risk for NAFLD was lower in MHO subjects than in MUNO subjects. PMID:26394730

  10. [Traumatic hip dislocation in children. Case report of a 4 year-old girl].

    PubMed

    Martínez-Guerrero, J I; Olguín-Hernández, F; Cabrera, A

    2012-01-01

    Traumatic hip dislocation with a history of high energy trauma is infrequent in children. The incidence rate in our country has not been determined in the literature. Everything depends on the patient's age group, the type of trauma and the ligament laxity of children. We report herein the case of a 4 year-old girl with this condition and a history of high energy trauma. She was seen at Aragón Pediatric Hospital, SSDF, 8 hours after the injury and received conservative treatment. She has done well so far and has been followed-up monthly for 18 months, without complications. Avascular necrosis of the femoral head is the most frequent complication and has irreversible sequelae. After the follow-up period the patient is totally functional and independent. PMID:23320340

  11. INDIRECT PULP TREATMENT IN A PERMANENT MOLAR: CASE REPORT OF 4-YEAR FOLLOW-UP

    PubMed Central

    Fagundes, Ticiane Cestari; Barata, Terezinha Jesus Esteves; Prakki, Anuradha; Bresciani, Eduardo; Pereira, José Carlos

    2009-01-01

    This case report describes the Indirect Pulp Treatment (IPT) of deep caries lesion in a permanent molar. A 16-year-old male patient reported discomfort associated with thermal stimulation on the permanent mandibular left first molar. The radiographs revealed a deep distal caries lesion, very close to the pulp, absence of radiolucencies in the periapical region, and absence of periodontal space thickening. Pulp sensitivity was confirmed by thermal pulp vitality tests. Based on the main complaint and the clinical and radiographic examinations, the treatment plan was established to preserve pulp vitality. Clinical procedures consisted of removing the infected dentin and lining the caries-affected dentin with calcium hydroxide paste. The tooth was provisionally sealed for approximately 60 days. After this period, tooth vitality was confirmed, the remaining carious dentin was removed, and the tooth was restored. At 4-year follow-up, no clinical or radiographic pathological findings were found. PMID:19148410

  12. Joint inversion of displacement and gravity changes at Mt. Etna volcano during the 1995-2000 period: results and conclusions

    NASA Astrophysics Data System (ADS)

    Fernandez, Jose; Camacho, Antonio; Carbone, Daniele; Bonforte, Alessandro; Guglielmino, Francesco; Puglisi, Giuseppe

    2015-04-01

    Persistent inflation and long-period gravity fluctuations were observed at Mt. Etna (Italy) during the time interval bounded by the 1991-93 and 2001 main flank eruptions. Past studies suggest that, since 1993 and before the 2001 eruption, a large amount of magma was stored at depth. Until now, a joint inversion of displacement and gravity data has not been performed. We carry out simultaneous inversion of gravity, GNSS and Advanced Differential InSAR displacement data covering the 1995-2000 period. Our inversion scheme uses bodies with a 3D free geometry to determine the best-fitting configuration of pressure and density sources. Results provide new insight into the shallow plumbing system of Etna. Inflation pressure sources are located below the northwestern flank, at depths of 4-6 km, while a mass source is located in a shallower position below the SE flank. Mass increases and decreases are observed without significant associated deformation. The neat separation between mass and pressure sources is a key feature to understand the processes which controlled the activity of Mt Etna during the studied period.

  13. The main results of the long-term measurements of the neutral atmosphere parameters by the artificial periodic irregularities techniques

    NASA Astrophysics Data System (ADS)

    Tolmacheva, Ariadna V.; Bakhmetieva, Nataliya V.; Grigoriev, Gennady I.; Kalinina, Elena E.

    2015-09-01

    The results of the atmospheric parameter determination by the method of artificial periodic irregularities (the API techniques) at the E-region heights obtained during many years of the observation are presented. The features of the obtaining data, their processing and the determination of the atmospheric parameters are given in details. A lot of information about dynamical phenomena in the lower thermosphere has been obtained. There are often height profiles of the atmospheric parameters with the wave-like variations and with the vertical scale of about 4-6 km. The temporal variations of the atmospheric parameters take place with the periods from 15 min to some hours. Such variations could be caused by the passage of the internal gravity waves (IGWs) and the tide waves. The temperature minima were observed as 100-140 K above 100 km in the equinoctial periods. The instability growth is also observed in the number of cases. The dependence of the neutral temperature and the density on solar and geomagnetic activity is not found.

  14. Insights Gained From 4 Years of EOSDIS User Surveys

    NASA Astrophysics Data System (ADS)

    Behnke, J.; Boquist, C. L.

    2007-12-01

    The Earth Observation System Data and Information System (EOSDIS) is a large, complex data system currently supporting over 18 operational NASA satellite missions including the flagship EOS missions: Terra, Aqua, and Aura. A critical underpinning for management of EOSDIS is developing a thorough knowledge of the EOSDIS user community and how they use the EOSDIS products in their research. It is important to know whether the system is meeting the users' needs and expectations. Thus, in 2004 NASA commissioned a comprehensive survey to determine user satisfaction using the American Customer Satisfaction Index (ACSI) approach. NASA has continued to survey users yearly since. Users continue to rate EOSDIS systems and services highly as the EOSDIS ACSI score has outperformed both the averages for U.S. companies and for Federal Agencies. In addition, users' comments have provided valuable insight into the effect of data center processes on users' experiences. Although their satisfaction has remained high, their preferences have changed with the rapid advances in web-based services. We now have four years of data on user satisfaction from these surveys. The results of each survey highlight areas that, if improved, could lead to increased user satisfaction, including overall product quality, product documentation, and product selection and ordering processes. This paper will present the survey results and how they compare from year to year.

  15. [Relationship between the intensity of gynecologic supervision during the postpartum period and fertility results in dairy cow herds].

    PubMed

    Bostedt, H; Maurer, G

    1990-10-01

    The efficiency of regular post-partum gynaecological care in the dairy cow can only be correctly evaluated if cows with a normal post-partum period and those with problems during this time are distinguished. From 1,125 dairy cows being fed a high proportion of maize silage it was shown that gynaecological examinations on days 12, 28 and 40 post-partum had a positive effect on herd fertility. Regular checks resulted in significant reductions in the calving to conception interval, the insemination index and in the percentage culled due to fertility problems in comparison to the control animals (n = 451) where veterinary control took place only occasionally. In particular the early detection and treatment of endometritis and ovary function abnormalities contributed to a high conception rate with appropriate calving interval. The administration of GnRH (20 micrograms Buserelin) to cows with problems in the post-partum period and under continuous gynaecological supervision resulted in improvements in only some aspects (uterine involution, ovarian cyst incidence). The conception rates in the treated group and in the intensively controlled group were the same. PMID:2124734

  16. Screening for developmental delay among children aged 1-4 years: a systematic review

    PubMed Central

    Warren, Rachel; Kenny, Meghan; Bennett, Teresa; Fitzpatrick-Lewis, Donna; Ali, Muhammad Usman; Sherifali, Diana; Raina, Parminder

    2016-01-01

    Background: Existing guidelines on screening children less than 5 years of age for developmental delay vary. In this systematic review, we synthesized the literature on the effectiveness and harms of screening for developmental delay in asymptomatic children aged 1-4 years. Methods: We searched MEDLINE, Embase and PsychINFO for relevant articles published to June 16, 2015. We identified studies that included children aged 1-4 years who were not at high risk of developmental delay, screened in a primary care setting. Randomized trials and controlled cohort studies were considered for benefits (cognitive, academic and functional outcomes); no restrictions on study design were imposed for the review of harms. Results: Two studies were included. One used the Ages and Stages Questionnaire II for screening and reported significantly more referrals to early intervention in the intervention groups than in the control group (relative risk [RR] 1.95, 95% confidence interval [CI] 1.49-2.54, in the intervention group with office support and RR 1.71, 95% CI 1.30-2.25, in the intervention group without office support). The time to referral was 70% shorter in the intervention group with office support (rate ratio 0.30, 95% CI 0.19-0.48) and 64% shorter in the intervention group without office support (rate ratio 0.36, 95% CI 0.23-0.59), compared with the control group. The other study used the VroegTijdige Onderkenning Ontwikkelingsstoornissen Language Screening instrument to screen children aged 15 months at enrolment for language delay. It reported no differences between groups in academic performance outcomes at age 8 years. Interpretation: The evidence on screening for developmental delay in asymptomatic children aged 1-4 years is inconclusive. Further research with longer-term outcomes is needed to inform decisions about screening and screening intervals. PMID:27226967

  17. The growth of the oceanic boundary layer during the COARE intensive observational period: Large Eddy simulation results

    SciTech Connect

    Skyllingstad, E.D.; Wijesekera, H.W.; Gregg, M.C.

    1995-03-01

    A principal goal of the Tropical Ocean Global Atmosphere (TOGA) Coupled Ocean-Atmosphere Response Experiment (COARE) is to gain an understanding of the processes that control mixing in the upper 100 m of the western tropical Pacific warm pool. The warm pool is an important heat reservoir for the global ocean and is responsible for many of the observed climatic changes associated with El Nino/Southern Oscillation (ENSO) events. This water mass is highly sensitive to mixed-layer processes that are controlled by surface heat, salinity, and momentum fluxes. During most of the year, these fluxes are dominated by solar heating and occasional squalls that freshen the top of the mixed layer and force shallow mixing of about 10-20 m. From November to April, the usual weather pattern is frequently altered by westerly wind bursts that are forced by tropical cyclones and intraseasonal oscillations. These wind bursts generate a strong eastward surface current and can force mixing as deep as 100 m over a period of days. Observations from the intensive observation period (IOP) in COARE indicate that mixed-layer deepening is accompanied by strong turbulence dissipation at the mixed layer base. A short westerly wind burst occurred during the first leg of TOGA-COARE, and lasted about 4-5 days. During this period, the maximum winds were about 10 m s{sup -1}, and the resulting eastward surface flow was about 0.5 m s{sup -1}. The strength of this event was somewhat weaker than a typical westerly wind burst, but the mixed-layer structure and growth are similar to the more vigorous wind bursts discussed.

  18. Social context effects in 2- and 4-year-olds' selective versus faithful imitation.

    PubMed

    Yu, Yue; Kushnir, Tamar

    2014-03-01

    This study asked whether children's tendency to imitate selectively (ignore causally unnecessary actions) versus faithfully (overimitate causally unnecessary actions) varies across ages and social contexts. In the first experiment, 2-year-olds and 4-year-olds were randomly assigned to play 1 of 3 prior games with a demonstrator: a mimicry game, an instrumental game, or a noninteractive control game. They then participated in a puzzle-box imitation task in which the demonstrator performed 1 causally necessary and 1 unnecessary action to retrieve an object. Whereas 4-year-olds imitated faithfully across all conditions, 2-year-olds were more likely to imitate faithfully after a mimicry game and to imitate selectively after an instrumental game. Experiment 2 showed no effect of playing a mimicry game with a different experimenter prior to the imitation trials, thus ruling out 2-year-olds' faithful imitation being the result of motor priming or training effects. The results are discussed in terms of children's social affiliation and social-cognitive inferences. PMID:23978298

  19. Results of dose sensors measurements in the middle-Earth orbit for the period of 2009-2015

    NASA Astrophysics Data System (ADS)

    Protopopov, Grigory; Shatov, Pavel; Tasenko, Sergey; Lyakhov, Igor; Makarova, Nina; Balashov, Sergey; Sitnikova, Ninel

    2016-07-01

    The measurements results of space radiation exposure on electronic components carried out by dose sensors are presented in the paper. Dose sensors operate on metal-nitride-oxide-semiconductor dosimetry pricniple. The flight data have been receiving for more than 6 years. The measurements results are compared with others flight data on different orbits. The analysis of the received data from 2009 to 2015 allows us to find out the periods with sharp increase of dose rate and to define values of such increases. We had analyzed space radiation characteristics data from other monitoring systems (such as GOES, Electro-L) in dates of dose rate sharp increase. Results of the analysis of dose rate increase, which had been fixed by TID sensors in 2015, will be presented in full paper. We had calculated average dose rates for different space models in the middle-Earth orbit (AE8, AE9 and others) and determined the most relevant models to the experimental data (with account for relaxation effect of dose sensor outputs). The comparison results for different models will be presented in the full paper. We had used different approaches for simulating of dose sensors shielding geometry, such as semi-sphere, semi-infinite plate, sector analysis, with taking account of different shielding elements. The analysis results of shielding configuration influence on calculated values of dose rate will be presented in the full paper.

  20. Experience with headwear influences the other-race effect in 4-year-old children.

    PubMed

    Suhrke, Janina; Freitag, Claudia; Lamm, Bettina; Teiser, Johanna; Poloczek, Sonja; Fassbender, Ina; Teubert, Manuel; Voehringer, Isabel; Keller, Heidi; Knopf, Monika; Lohaus, Arnold; Schwarzer, Gudrun

    2015-09-01

    The other-race effect (ORE) implies the better recognition of faces of one's own race compared with faces of a different race. It demonstrates that face recognition is shaped by daily experience with human faces. Such experience mainly includes structural information of own-race faces and also information on the way faces are usually seen, as a whole or partly covered by scarves or other headwear. In two experiments, we investigated how this mode of presentation is related to the occurrence of the ORE during childhood. In Experiment 1, 4-year-old German children (N = 104), accustomed to seeing faces without headwear in daily life, were asked to recognize female Caucasian or African faces, presented either as a whole or wearing a woolen hat, in a forced choice paradigm. In Experiment 2, 4-year-olds from rural Cameroon (N = 70), accustomed to seeing faces with and without headwear in daily life, participated in the same task. In both groups, the ORE was present in the familiar mode of presentation, that is, in whole faces in German children and in whole and partly covered faces in Cameroonian children. The results are discussed in relation to the role of experience for face recognition processes. PMID:25935463

  1. A longitudinal study of the emerging self from 9 months to the age of 4 years.

    PubMed

    Kristen-Antonow, Susanne; Sodian, Beate; Perst, Hannah; Licata, Maria

    2015-01-01

    The aim of this study was to investigate if children's early responsiveness toward social partners is developmentally related to their growing concept of self, as reflected in their mirror self-recognition (MSR) and delayed self-recognition (DSR). Thus, a longitudinal study assessed infants' responsiveness (e.g., smiling, gaze) toward social partners during the still-face (SF) task and a social imitation game and related it to their emerging MSR and DSR. Thereby, children were tested at regular time points from 9 months to 4 years of age. Results revealed significant predictive relations between children's responsiveness toward a social partner in the SF task at 9 months and their MSR at 24 months. Further, interindividual differences in children's awareness of and responsiveness toward being imitated in a social imitation game at 12 months proved to be the strongest predictor of children's DSR at 4 years, while some additional variance was explained by MSR at 24 months and verbal intelligence. Overall, findings suggest a developmental link between children's early awareness of and responsiveness toward the social world and their later ability to form a concept of self. PMID:26113834

  2. A measure of inspection time in 4-year-old children: the Benny Bee IT task.

    PubMed

    Williams, Sarah E; Turley, Christopher; Nettelbeck, Ted; Burns, Nicholas R

    2009-09-01

    Inspection time (IT) measures speed of information processing without the confounding influence of motor speed. While IT has been found to relate to cognitive abilities in adults and older children, no measure of IT has been validated for use with children younger than 6 years. This study examined the validity of a new measure of IT for preschool children. N = 71 4-year-old children completed the new IT task and standardized measures of fluid ability, visuospatial ability, and speed of processing. N = 50 adults completed the same tasks and, additionally, a standard IT task. Results showed that the new IT task is a stable, reliable measure of IT in 4-year-old children. The new task had reasonable concurrent validity with the standard IT task in adults and the relationships between cognitive abilities, particularly general cognitive ability, and IT are sufficiently similar in young children and adults to suggest that the new IT task may be a useful tool for research in populations where IT was previously not measurable. PMID:19994574

  3. A longitudinal study of the emerging self from 9 months to the age of 4 years

    PubMed Central

    Kristen-Antonow, Susanne; Sodian, Beate; Perst, Hannah; Licata, Maria

    2015-01-01

    The aim of this study was to investigate if children’s early responsiveness toward social partners is developmentally related to their growing concept of self, as reflected in their mirror self-recognition (MSR) and delayed self-recognition (DSR). Thus, a longitudinal study assessed infants’ responsiveness (e.g., smiling, gaze) toward social partners during the still-face (SF) task and a social imitation game and related it to their emerging MSR and DSR. Thereby, children were tested at regular time points from 9 months to 4 years of age. Results revealed significant predictive relations between children’s responsiveness toward a social partner in the SF task at 9 months and their MSR at 24 months. Further, interindividual differences in children’s awareness of and responsiveness toward being imitated in a social imitation game at 12 months proved to be the strongest predictor of children’s DSR at 4 years, while some additional variance was explained by MSR at 24 months and verbal intelligence. Overall, findings suggest a developmental link between children’s early awareness of and responsiveness toward the social world and their later ability to form a concept of self. PMID:26113834

  4. Three- and 4-year-old children's response tendencies to various interviewers.

    PubMed

    Okanda, Mako; Kanda, Takayuki; Ishiguro, Hiroshi; Itakura, Shoji

    2013-09-01

    Unlike young preschoolers, older preschoolers may exhibit a response bias under social pressure from authoritative interviewers. To examine this, 3- and 4-year-old preschoolers were asked yes-no questions about familiar and unfamiliar objects in three conditions. In one condition an adult asked them questions in a live interaction, in a second condition an adult asked questions via video, and in a third condition a robot asked questions via video. The 3-year-olds exhibited a yes bias-a tendency to say "yes"-in nearly all conditions. The only exception was when they were asked questions about unfamiliar objects by the human interviewer via video, where they did not respond in a biased manner. The 4-year-olds exhibited a yes bias in only one condition-when they were questioned by a live human interviewer about both objects. They also exhibited a nay-saying bias when asked questions about unfamiliar objects in both video conditions, and they did not show any response bias in other conditions. The results suggest that the social pressure from an authoritative adult in a live interaction is problematic. PMID:23664558

  5. Integrating across episodes: Investigating the long-term accessibility of self-derived knowledge in 4-year-old children.

    PubMed

    Varga, Nicole L; Stewart, Rebekah A; Bauer, Patricia J

    2016-05-01

    Semantic memory, defined as our store of knowledge about the world, provides representational support for all of our higher order cognitive functions. As such, it is crucial that the contents of semantic memory remain accessible over time. Although memory for knowledge learned through direct observation has been investigated previously, we know very little about the retention of knowledge derived through integration of information acquired across separate learning episodes. The current research investigated cross-episode integration in 4-year-old children. Participants were presented with novel facts via distinct story episodes and tested for knowledge extension through cross-episode integration as well as for retention of the information over a 1-week delay. In Experiment 1, children retained the self-derived knowledge over the delay, although performance was primarily evidenced in a forced-choice format. In Experiment 2, we sought to facilitate the accessibility and robustness of self-derived knowledge by providing a verbal reminder after the delay. The accessibility of self-derived knowledge increased irrespective of whether participants successfully demonstrated knowledge of the integration facts during the first visit. The results suggest that knowledge extended through integration remains accessible after delays even in a population where this learning process is less robust. The findings also demonstrate the facilitative effect of reminders on the accessibility and further extension of knowledge over extended time periods. PMID:26774259

  6. Searches for periodic gravitational waves from unknown isolated sources and Scorpius X-1: Results from the second LIGO science run

    NASA Astrophysics Data System (ADS)

    Abbott, B.; Abbott, R.; Adhikari, R.; Agresti, J.; Ajith, P.; Allen, B.; Amin, R.; Anderson, S. B.; Anderson, W. G.; Arain, M.; Araya, M.; Armandula, H.; Ashley, M.; Aston, S.; Aufmuth, P.; Aulbert, C.; Babak, S.; Ballmer, S.; Bantilan, H.; Barish, B. C.; Barker, C.; Barker, D.; Barr, B.; Barriga, P.; Barton, M. A.; Bayer, K.; Belczynski, K.; Berukoff, S. J.; Betzwieser, J.; Beyersdorf, P. T.; Bhawal, B.; Bilenko, I. A.; Billingsley, G.; Biswas, R.; Black, E.; Blackburn, K.; Blackburn, L.; Blair, B.; Bland, B.; Bogenstahl, J.; Bogue, L.; Bork, R.; Boschi, V.; Bose, S.; Brady, P. R.; Braginsky, V. B.; Brau, J. E.; Brinkmann, M.; Brooks, A.; Brown, D. A.; Bullington, A.; Bunkowski, A.; Buonanno, A.; Burmeister, O.; Busby, D.; Butler, W. E.; Byer, R. L.; Cadonati, L.; Cagnoli, G.; Camp, J. B.; Cannizzo, J.; Cannon, K.; Cantley, C. A.; Cao, J.; Cardenas, L.; Carter, K.; Casey, M. M.; Castaldi, G.; Cepeda, C.; Chalkey, E.; Charlton, P.; Chatterji, S.; Chelkowski, S.; Chen, Y.; Chiadini, F.; Chin, D.; Chin, E.; Chow, J.; Christensen, N.; Clark, J.; Cochrane, . P.; Cokelaer, T.; Colacino, C. N.; Coldwell, R.; Coles, M.; Conte, R.; Cook, D.; Corbitt, T.; Coward, D.; Coyne, D.; Creighton, J. D. E.; Creighton, T. D.; Croce, R. P.; Crooks, D. R. M.; Cruise, A. M.; Csatorday, P.; Cumming, A.; Cutler, C.; Dalrymple, J.; D'Ambrosio, E.; Danzmann, K.; Davies, G.; Daw, E.; Debra, D.; Degallaix, J.; Degree, M.; Delker, T.; Demma, T.; Dergachev, V.; Desai, S.; Desalvo, R.; Dhurandhar, S.; Díaz, M.; Dickson, J.; di Credico, A.; Diederichs, G.; Dietz, A.; Ding, H.; Doomes, E. E.; Drever, R. W. P.; Dumas, J.-C.; Dupuis, R. J.; Dwyer, J. G.; Ehrens, P.; Espinoza, E.; Etzel, T.; Evans, M.; Evans, T.; Fairhurst, S.; Fan, Y.; Fazi, D.; Fejer, M. M.; Finn, L. S.; Fiumara, V.; Fotopoulos, N.; Franzen, A.; Franzen, K. Y.; Freise, A.; Frey, R.; Fricke, T.; Fritschel, P.; Frolov, V. V.; Fyffe, M.; Galdi, V.; Ganezer, K. S.; Garofoli, J.; Gholami, I.; Giaime, J. A.; Giampanis, S.; Giardina, K. D.; Goda, K.; Goetz, E.; Goggin, L. M.; González, G.; Gossler, S.; Grant, A.; Gras, S.; Gray, C.; Gray, M.; Greenhalgh, J.; Gretarsson, A. M.; Grosso, R.; Grote, H.; Grunewald, S.; Guenther, M.; Gustafson, R.; Hage, B.; Hammer, D.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G.; Harstad, E.; Hayler, T.; Heefner, J.; Heinzel, G.; Heng, I. S.; Heptonstall, A.; Heurs, M.; Hewitson, M.; Hild, S.; Hirose, E.; Hoak, D.; Hosken, D.; Hough, J.; Howell, E.; Hoyland, D.; Huttner, S. H.; Ingram, D.; Innerhofer, E.; Ito, M.; Itoh, Y.; Ivanov, A.; Jackrel, D.; Jennrich, O.; Johnson, B.; Johnson, W. W.; Johnston, W. R.; Jones, D. I.; Jones, G.; Jones, R.; Ju, L.; Kalmus, P.; Kalogera, V.; Kasprzyk, D.; Katsavounidis, E.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kells, W.; Keppel, D. G.; Khalili, F. Ya.; Killow, C. J.; Kim, C.; King, P.; Kissell, J. S.; Klimenko, S.; Kokeyama, K.; Kondrashov, V.; Kopparapu, R. K.; Kozak, D.; Krishnan, B.; Kwee, P.; Lam, P. K.; Landry, M.; Lantz, B.; Lazzarini, A.; Lee, B.; Lei, M.; Leiner, J.; Leonhardt, V.; Leonor, I.; Libbrecht, K.; Libson, A.; Lindquist, P.; Lockerbie, N. A.; Logan, J.; Longo, M.; Lormand, M.; Lubiński, M.; Lück, H.; Machenschalk, B.; Macinnis, M.; Mageswaran, M.; Mailand, K.; Malec, M.; Mandic, V.; Marano, S.; Márka, S.; Markowitz, J.; Maros, E.; Martin, I.; Marx, J. N.; Mason, K.; Matone, L.; Matta, V.; Mavalvala, N.; McCarthy, R.; McClelland, D. E.; McGuire, S. C.; McHugh, M.; McKenzie, K.; McNabb, J. W. C.; McWilliams, S.; Meier, T.; Melissinos, A.; Mendell, G.; Mercer, R. A.; Meshkov, S.; Messaritaki, E.; Messenger, C. J.; Meyers, D.; Mikhailov, E.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Miyakawa, O.; Mohanty, S.; Moreno, G.; Mossavi, K.; Mowlowry, C.; Moylan, A.; Mudge, D.; Mueller, G.; Mukherjee, S.; Müller-Ebhardt, H.; Munch, J.; Murray, P.; Myers, E.; Myers, J.; Nagano, S.; Nash, T.; Newton, G.; Nishizawa, A.; Nocera, F.; Numata, K.; Nutzman, P.; O'Reilly, B.; O'Shaughnessy, R.; Ottaway, D. J.; Overmier, H.; Owen, B. J.; Pan, Y.; Papa, M. A.; Parameshwaraiah, V.; Parameswariah, C.; Patel, P.; Pedraza, M.; Penn, S.; Pierro, V.; Pinto, I. M.; Pitkin, M.; Pletsch, H.; Plissi, M. V.; Postiglione, F.; Prix, R.; Quetschke, V.; Raab, F.; Rabeling, D.; Radkins, H.; Rahkola, R.; Rainer, N.; Rakhmanov, M.; Ramsunder, M.; Rawlins, K.; Ray-Majumder, S.; Re, V.; Regimbau, T.; Rehbein, H.; Reid, S.; Reitze, D. H.; Ribichini, L.; Richman, S.; Riesen, R.; Riles, K.; Rivera, B.; Robertson, N. A.; Robinson, C.; Robison, E. L.; Roddy, S.; Rodriguez, A.; Rogan, A. M.; Rollins, J.; Romano, J. D.; Romie, J.; Rong, H.; Route, R.; Rowan, S.; Rüdiger, A.; Ruet, L.; Russell, P.; Ryan, K.; Sakata, S.; Samidi, M.; Sancho de La Jordana, L.; Sandberg, V.; Sanders, G. H.; Sannibale, V.; Saraf, S.; Sarin, P.; Sathyaprakash, B.; Sato, S.; Saulson, P. R.; Savage, R.; Savov, P.; Sazonov, A.; Schediwy, S.; Schilling, R.; Schnabel, R.; Schofield, R.; Schutz, B. F.; Schwinberg, P.; Scott, S. M.; Searle, A. C.; Sears, B.; Seifert, F.; Sellers, D.; Sengupta, A. S.; Shawhan, P.; Shoemaker, D. H.; Sibley, A.; Sidles, J. A.; Siemens, X.; Sigg, D.; Sinha, S.; Sintes, A. M.; Slagmolen, B. J. J.; Slutsky, J.; Smith, J. R.; Smith, M. R.; Somiya, K.; Strain, K. A.; Strand, N. E.; Strom, D. M.; Stuver, A.; Summerscales, T. Z.; Sun, K.-X.; Sung, M.; Sutton, P. J.; Sylvestre, J.; Takahashi, H.; Takamori, A.; Tanner, D. B.; Tarallo, M.; Taylor, R.; Taylor, R.; Thacker, J.; Thorne, K. A.; Thorne, K. S.; Thüring, A.; Tinto, M.; Tokmakov, K. V.; Torres, C.; Torrie, C.; Traylor, G.; Trias, M.; Tyler, W.; Ugolini, D.; Ungarelli, C.; Urbanek, K.; Vahlbruch, H.; Vallisneri, M.; van den Broeck, C.; van Putten, M.; Varvella, M.; Vass, S.; Vecchio, A.; Veitch, J.; Veitch, P.; Villar, A.; Vorvick, C.; Vyachanin, S. P.; Waldman, S. J.; Wallace, L.; Ward, H.; Ward, R.; Watts, K.; Webber, D.; Weidner, A.; Weinert, M.; Weinstein, A.; Weiss, R.; Wen, L.; Wen, S.; Wette, K.; Whelan, J. T.; Whitbeck, D.. M.; Whitcomb, S. E.; Whiting, B. F.; Wiley, S.; Wilkinson, C.; Willems, P. A.; Williams, L.; Willke, B.; Wilmut, I.; Winkler, W.; Wipf, C. C.; Wise, S.; Wiseman, A. G.; Woan, G.; Woods, D.; Wooley, R.; Worden, J.; Wu, W.; Yakushin, I.; Yamamoto, H.; Yan, Z.; Yoshida, S.; Yunes, N.; Zaleski, K. D.; Zanolin, M.; Zhang, J.; Zhang, L.; Zhao, C.; Zotov, N.; Zucker, M.; Zur Mühlen, H.; Zweizig, J.

    2007-10-01

    We carry out two searches for periodic gravitational waves using the most sensitive few hours of data from the second LIGO science run. Both searches exploit fully coherent matched filtering and cover wide areas of parameter space, an innovation over previous analyses which requires considerable algorithm development and computational power. The first search is targeted at isolated, previously unknown neutron stars, covers the entire sky in the frequency band 160 728.8 Hz, and assumes a frequency derivative of less than 4×10-10Hz/s. The second search targets the accreting neutron star in the low-mass x-ray binary Scorpius X-1 and covers the frequency bands 464 484 Hz and 604 624 Hz as well as the two relevant binary orbit parameters. Because of the high computational cost of these searches we limit the analyses to the most sensitive 10 hours and 6 hours of data, respectively. Given the limited sensitivity and duration of the analyzed data set, we do not attempt deep follow-up studies. Rather we concentrate on demonstrating the data analysis method on a real data set and present our results as upper limits over large volumes of the parameter space. In order to achieve this, we look for coincidences in parameter space between the Livingston and Hanford 4-km interferometers. For isolated neutron stars our 95% confidence level upper limits on the gravitational wave strain amplitude range from 6.6×10-23 to 1×10-21 across the frequency band; for Scorpius X-1 they range from 1.7×10-22 to 1.3×10-21 across the two 20-Hz frequency bands. The upper limits presented in this paper are the first broadband wide parameter space upper limits on periodic gravitational waves from coherent search techniques. The methods developed here lay the foundations for upcoming hierarchical searches of more sensitive data which may detect astrophysical signals.

  7. Sensitivity of 4-Year-Olds to Featural and Second-Order Relational Changes in Face Distinctiveness

    ERIC Educational Resources Information Center

    McKone, Elinor; Boyer, Barbara L.

    2006-01-01

    Sensitivity to adult ratings of facial distinctiveness (how much an individual stands out in a crowd) has been demonstrated previously in children age 5 years or older. Experiment 1 extended this result to 4-year-olds using a "choose the more distinctive face" task. Children's patterns of choice across item pairs also correlated well with those of…

  8. Comparison of SAFER behavior assessment results in shelter dogs at intake and after a 3-day acclimation period.

    PubMed

    Bennett, Sara L; Weng, Hsin-Yi; Walker, Sheryl L; Placer, Margaret; Litster, Annette

    2015-01-01

    In this study, it was hypothesized that different results would be obtained by canine behavior assessments performed within 24 hr of shelter intake (Day 0) and after a 3-day acclimation period (Day 3). Safety Assessment for Evaluating Rehoming assessments were performed on 33 dogs at 2 municipal shelters. Agreements between Day 0 and Day 3 varied among subtests, and no consistent temporal patterns were observed. Weighted kappa statistics for each subtest ranged from .28 to .78, and percentage discordance was 0% to 18%. In a 2nd analysis, subtests skipped due to serious aggression were replaced with scores corresponding to serious aggression, and missing values for the Food subtest were replaced with scores for no aggression if the dog did not eat. For subtests skipped due to severe aggression, more than 50% of the dogs had scores indicating low aggression on the other assessment. Eight of 16 dogs who did not eat on Day 0 ate on Day 3; 2 showed aggression. Until the ideal time to test can be identified, it should be based on the individual dog's welfare status, and testing of dogs showing severe stress should be avoided. PMID:25603466

  9. [School attendance of children with trisomy 21. A 4-year experiment].

    PubMed

    Stoll, C; Roth, M P

    1983-04-28

    Four years ago a class was started with 8 children from 7 to 11 years of age with Down's syndrome. The classroom is in a state school. The children lived at home. They were with the other children of the school for several classes and for lunch. Like other children they learned reading, writing and arithmetic. Psychomotricity was emphasized. The children's I.Q. and behavior were studied before entering the class. After 24 to 30 months every child was able to read and write. Their I.Q.'s were retested after 4 years and the results were far better than previously. The children gained confidence and began to cope very well at school and outside school. PMID:6306812

  10. 26 CFR 1.702-3T - 4-Year spread (temporary).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... partnership items over 4 years, regardless of whether such election was in fact made. Thus, for example, if a... partnership items are taken into account under the rules of this section. Thus, for example, a partner who does not elect out of the 4-year spread must take into account, for purposes of determining...

  11. 26 CFR 1.702-3T - 4-Year spread (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false 4-Year spread (temporary). 1.702-3T Section 1.702-3T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Partners and Partnerships § 1.702-3T 4-Year spread (temporary). (a) Applicability. This section applies to...

  12. Institutional Characteristics Contributing to the Effectiveness of 4-Year Business Degrees

    ERIC Educational Resources Information Center

    Book-Ellard, Tracy Lynn

    2012-01-01

    Over $8 billion is spent yearly, on college education in one Southern U.S. state, yet the employment effectiveness of public and private 4-year undergraduate business degrees (effectiveness defined as obtaining employment or entering into a degree program requiring a 4-year business degree by the end of Year 1 and remaining employed or in a degree…

  13. Should Community College Students Earn an Associate Degree before Transferring to a 4-Year Institution?

    ERIC Educational Resources Information Center

    Kopko, Elizabeth M.; Crosta, Peter M.

    2016-01-01

    Using data on over 41,000 students in one state who entered community college before transferring to a 4-year institution, this study examines the following question: Are community college students who earn an associate degree before transferring to a 4-year college more likely to earn a bachelor's degree? Due to the causal nature surrounding this…

  14. 42 CFR 414.42 - Adjustment for first 4 years of practice.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Adjustment for first 4 years of practice. 414.42 Section 414.42 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Other Practitioners § 414.42 Adjustment for first 4 years of practice. (a) General rule. For...

  15. 42 CFR 414.42 - Adjustment for first 4 years of practice.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Adjustment for first 4 years of practice. 414.42 Section 414.42 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Other Practitioners § 414.42 Adjustment for first 4 years of practice. (a) General rule. For...

  16. The Maine Question: How Is 4-Year College Enrollment Affected by Mandatory College Entrance Exams?

    ERIC Educational Resources Information Center

    Hurwitz, Michael; Smith, Jonathan; Niu, Sunny; Howell, Jessica

    2015-01-01

    We use a difference-in-differences analytic approach to estimate postsecondary consequences from Maine's mandate that all public school juniors take the SAT®. We find that, overall, the policy increased 4-year college-going rates by 2- to 3-percentage points and that 4-year college-going rates among induced students increased by 10-percentage…

  17. Changes in Early Childhood: Public School Programs for 4-Year-Olds.

    ERIC Educational Resources Information Center

    Lawler, S. Dianne; Boals, Beverly M.

    Education programs for 4-year-olds may offer unique opportunities for the growth of services for young children. Currently, the role of state departments of education in preschool instruction is evolving; no single approach to public school programming for 4-year-olds exists. Approximately two-thirds of the 28 state and District of Columbia early…

  18. Smoking Patterns, Attitudes and Motives: Unique Characteristics among 2-Year versus 4-Year College Students

    ERIC Educational Resources Information Center

    Berg, C. J.; An, L. C.; Thomas, J. L.; Lust, K. A.; Sanem, J. R.; Swan, D. W.; Ahluwalia, J. S.

    2011-01-01

    Given the previously documented higher rates of smoking among 2-year college students in comparison with 4-year university students, this study compares smoking patterns, attitudes and motives among 2-year and 4-year college students. Two thousand two hundred and sixty-five undergraduate students aged 18-25 years at a 2-year college and a 4-year…

  19. 42 CFR 414.42 - Adjustment for first 4 years of practice.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Adjustment for first 4 years of practice. 414.42 Section 414.42 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Physicians and Other Practitioners § 414.42 Adjustment for first 4 years of practice. (a) General rule....

  20. 42 CFR 414.42 - Adjustment for first 4 years of practice.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Adjustment for first 4 years of practice. 414.42 Section 414.42 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Physicians and Other Practitioners § 414.42 Adjustment for first 4 years of practice. (a) General rule....

  1. 26 CFR 1.702-3T - 4-Year spread (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false 4-Year spread (temporary). 1.702-3T Section 1... (CONTINUED) INCOME TAXES Partners and Partnerships § 1.702-3T 4-Year spread (temporary). (a) Applicability... spread. A partner may elect out of the rules of paragraph (b) of this section by meeting the...

  2. 26 CFR 1.702-3T - 4-Year spread (temporary).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 8 2012-04-01 2012-04-01 false 4-Year spread (temporary). 1.702-3T Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Partners and Partnerships § 1.702-3T 4-Year spread (temporary). (a... taxable year for the first taxable year beginning after December 31, 1986 (partnership's year of...

  3. Ameloblastic Fibro-Odontoma in a 4-Year-Old Boy

    PubMed Central

    Ghandehari-Motlagh, Mehdi; Khosravi, Zahra; Meighani, Ghasem; Baradaran-Nakhjavani, Yahya

    2016-01-01

    Introduction Ameloblastic fibro-odontoma (AFO) is defined as a benign odontogenic tumor with slow growing behavior. Its prevalence is rare. AFO is characterized by histologic features of ameloblastic fibroma (AF) with the formation of enamel and dentine. Case Presentation This is a case report of AFO accompanied with a number of impacted deciduous teeth and its management in a 4-year old boy. Examination of oral cavity revealed an extensive swelling from midline to left deciduous maxillary first molar, covered with normal mucosa. Radiographic examination showed a well-defined mixed radiolucent-radiopaque lesion that extended horizontally from midline to mesial border of the left maxillary primary first molar and vertically from alveolar crest to the floor of nose. The differential diagnosis was odontoma (ameloblastic fibro-odontoma, complex odontoma). Surgical enucleation and curettage was performed under general anesthesia. Histopathologic sections show bone trabeculae in marrow spaces. There was myxoid matrix in some spaces which contained odontogenic epithelial cells. These findings led to diagnosis of AFO. No sign of recurrence has been observed during the 12-month follow-up period. Conclusion Although AFO is a rare tumor, it is more prevalent in childrenʼs jaw. Conservative surgical treatment allowed the normal development of teeth. PMID:27307963

  4. The Impact of Admission Diagnosis on Recurrent or Frequent Hospitalizations in 3 Dementia Subtypes: A Hospital-Based Cohort in Taiwan with 4 Years Longitudinal Follow-Ups.

    PubMed

    Chang, Chiung-Chih; Lin, Pin-Hsuan; Chang, Ya-Ting; Chen, Nai-Ching; Huang, Chi-Wei; Lui, Chun-Chung; Huang, Shu-Hua; Chang, Yen-Hsiang; Lee, Chen-Chang; Lai, Wei-An

    2015-11-01

    Increasing numbers of patients with different types of dementia have resulted in the increasing medical care loads. It is not known whether explanatory factors for recurrent or prolong hospitalization were driven by the subtypes of dementia. We analyzed 203 dementia patients aged >65-year-old with a clinical diagnosis of Alzheimer disease (AD), vascular dementia (VaD), or Parkinsonism-related dementia (PRD). With a 4-year follow-up period, logistic regression analyses were used to identify predictors of dementia diagnosis, cerebrovascular risk factors, chronic systemic diseases, and the etiology for admission for recurrent (>4 times/4 years) or prolonged hospitalization stay (>14 days per hospitalization). There were 48 AD, 96 VaD, and 59 PRD patients that completed the 4-year study. The average length of hospital stay was significant, the shortest in AD and the longest in PRD (P = 0.01), whereas the frequency of hospitalization was not different among 3 dementia subtypes. Although delirium is the most common etiology for admission in the patients, diabetes mellitus (Odds ratio, OR = 2.79, P = 0.02), pneumonia (OR = 11.21, P < 0.001), and fall-related hip fracture (OR = 4.762, P = 0.029) were significantly associated with prolong hospitalization. Patients with coronary artery disease (OR = 9.87, P = 0.02), pneumonia (OR = 84.48, P < 0.001), urinary tract infection (OR = 55.09, P < 0.001), and fall-related fracture (OR = 141.7, P < 0.001) predict recurrent hospitalization. Dementia subtypes did not influence directly on the hospitalization courses. The etiologies for admission carried higher clinical significance, compared with the coexisted systemic diseases. PMID:26579820

  5. Health risk factors and the incidence of hypertension: 4-year prospective findings from a national cohort of 60 569 Thai Open University students

    PubMed Central

    Thawornchaisit, Prasutr; de Looze, Ferdinandus; Reid, Christopher M; Seubsman, Sam-ang; Sleigh, Adrian C

    2013-01-01

    Objective This study evaluates the impact of a number of demographic, biological, behavioural and lifestyle health risk factors on the incidence of hypertension in Thailand over a 4-year period. Design A 4-year prospective study of health risk factors and their effects on the incidence of hypertension in a national Thai Cohort Study from 2005 to 2009. Setting As Thailand is transitioning from a developing to a middle-income developed country, chronic diseases (particularly cardiovascular disease) have emerged as major health issues. Hypertension is a major risk factor for heart attack and stroke and cross-sectional studies have indicated that the prevalence is increasing. Study participants A total of 57 558 Sukhothai Thammathirat Open University students who participated in both the 2005 and 2009 questionnaire surveys and who were normotensive in 2005 were included in the analysis. Measures Adjusted relative risks associating each risk factor and incidence of hypertension by sex, after controlling for confounders such as age, socioeconomic status, body mass index (BMI) and underlying diseases. Results The overall 4-year incidence of hypertension was 3.5%, with the rate in men being remarkably higher than that in women (5.2% vs 2.1%). In both sexes, hypertension was associated with age, higher BMI and comorbidities but not with income and education. In men, hypertension was associated with physical inactivity, smoking, alcohol and fast food intake. In women, hypertension was related to having a partner. Conclusions In both men and women, hypertension was strongly associated with age, obesity and comorbidities while it had no association with socioeconomic factors. The cohort patterns of socioeconomy and hypertension reflect that the health risk transition in Thais is likely to be at the middle stage. Diet and lifestyle factors associate with incidence of hypertension in Thais and may be amenable targets for hypertension control programmes. PMID:23801711

  6. Microperimetric Assessment after Epiretinal Membrane Surgery: 4-Year Follow-Up

    PubMed Central

    Dal Vecchio, Marco; Lavia, Carlo; Nassisi, Marco; Grignolo, Federico M.; Fea, Antonio M.

    2016-01-01

    Purpose. To investigate retinal function using microperimetry in patients affected by idiopathic epiretinal membrane (iERM) and cataract who underwent combined surgery: 4-year follow-up. Design. Prospective, interventional case series. Methods. 30 eyes of 30 consecutive patients with iERM and age-related cataract underwent 25-gauge vitrectomy and cataract surgery. At baseline, 90 and 180 days, and 1 and 4 years, we examined retinal mean sensitivity (MS), retinal mean defect (MD), fixation stability, and frequency of microscotomas using MP1 microperimetry. Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) using a spectral domain optical coherence tomography (SD-OCT) were also performed. Results. All patients completed 1-year follow-up, while 23 patients reached last follow-up. Baseline MS and MD (10.48 ± 4.17 and −9.18 ± 4.40 dB) significantly changed at one year (12.33 ± 3.66 and −7.49 ± 3.31 dB, p < 0.01), at four years (14.18 ± 3.46 and −4.66 ± 2.85, p < 0.01), and between one and four years (p < 0.01) after surgery. Compared to baseline, CRT and BCVA significantly changed at one year and remained stable at four years. No variations were observed in fixation stability and frequency of microscotomas compared to baseline. Conclusions. Long-term follow-up using microperimetry seems useful to evaluate patients after iERM surgery: retinal sensitivity changes even when BCVA and CRT remain stable. PMID:27088008

  7. Changes in soil chemical and microbiological properties during 4 years of application of various organic residues.

    PubMed

    Odlare, M; Pell, M; Svensson, K

    2008-01-01

    A 4-year field trial was established in eastern Sweden to evaluate the effects of organic waste on soil chemical and microbiological variables. A simple crop rotation with barley and oats was treated with either compost from household waste, biogas residue from household waste, anaerobically treated sewage sludge, pig manure, cow manure or mineral fertilizer. All fertilizers were amended in rates corresponding to 100kgNha(-1)year(-1). The effects of the different types of organic waste were evaluated by subjecting soil samples, taken each autumn 4 weeks after harvest, to an extensive set of soil chemical (pH, Org-C, Tot-N, Tot-P, Tot-S, P-AL, P-Olsen, K-AL, and some metals) and microbiological (B-resp, SIR, microSIR active and dormant microorganisms, PDA, microPDA, PAO, Alk-P and N-min) analyses. Results show that compost increased pH, and that compost as well as sewage sludge increased plant available phosphorus; however, the chemical analysis showed few clear trends over the 4 years and few clear relations to plant yield or soil quality. Biogas residues increased substrate induced respiration (SIR) and, compared to the untreated control amendment of biogas residues as well as compost, led to a higher proportion of active microorganisms. In addition, biogas residues increased potential ammonia oxidation rate (PAO), nitrogen mineralization capacity (N-min) as well as the specific growth rate constant of denitrifiers (microPDA). Despite rather large concentrations of heavy metals in some of the waste products, no negative effects could be seen on either chemical or microbiological soil properties. Changes in soil microbial properties appeared to occur more rapidly than most chemical properties. This suggests that soil microbial processes can function as more sensitive indicators of short-term changes in soil properties due to amendment of organic wastes. PMID:17697770

  8. Minimum 4-Year Outcomes of Cervical Total Disc Arthroplasty Versus Fusion

    PubMed Central

    Wu, Ai-Min; Xu, Hui; Mullinix, Kenneth Paul; Jin, Hai-Ming; Huang, Zhe-Yu; Lv, Qing-Bo; Wang, Sheng; Xu, Hua-Zi; Chi, Yong-Long

    2015-01-01

    Abstract The prevalence of cervical disc disease is high, and the traditional surgical method of anterior cervical discectomy and fusion (ACDF) carries with it the disadvantages of motion loss at the operated level, and accelerated adjacent level disc degeneration. Preliminary results of the efficacy and reoperative rate comparing TDA versus ACDF have been reported; however, the long-term outcomes of TDA versus ACDF still remain a topic of debate. This review was prepared following the standard procedures set forth by the Cochrane Collaboration organization, and preferred reporting items for systematic reviews and meta-analyses (PRISMA). The only studies included were randomized controlled trials with a minimum of 4 years of follow-up data. The meta-analysis included the neck disability index (NDI), visual analog scale (VAS) of neck and arm pain, SF-36 physical component scores (SF-36 PCS), over success, neurological success, work status, implant-related complications, and secondary surgery events. Four randomized controlled trials meet the inclusion criteria. The long-term improvement of NDI, VAS of neck and arm pain, SF-36 PCS, over success, and neurological success favored the TDA group. The TDA group also had a lower incidence of secondary surgery for both the index level (RR: 0.45 [0.28, 0.72]) and adjacent level (RR: 0.53 [0.33, 0.88]). In this meta-analysis of 4 included RCTs with a minimum 4 years of follow-ups, total disc arthroplasty showed improvements over ACDF as measured by the NDI, VAS of neck and arm pain, and SF-36 PCS. PMID:25881841

  9. Self-critical perfectionism and depressive and anxious symptoms over 4 years: The mediating role of daily stress reactivity.

    PubMed

    Mandel, Tobey; Dunkley, David M; Moroz, Molly

    2015-10-01

    This study of 150 community adults examined heightened emotional reactivity to daily stress as a mediator in the relationships between self-critical (SC) perfectionism and depressive and anxious symptoms over a period of 4 years. Participants completed questionnaires assessing: perfectionism dimensions, general depressive symptoms (i.e., shared with anxiety), specific depressive symptoms (i.e., anhedonia), general anxious symptoms (i.e., shared with depression), and specific anxious symptoms (i.e., somatic anxious arousal) at Time 1; daily stress and affect (e.g., sadness, negative affect) for 14 consecutive days at Month 6 and Year 3; and depressive and anxious symptoms at Year 4. Path analyses indicated that SC perfectionism predicted daily stress-sadness reactivity (i.e., greater increases in sadness in response to increases in stress) across Month 6 and Year 3, which in turn explained why individuals with higher SC perfectionism had more general depressive symptoms, anhedonic depressive symptoms, and general anxious symptoms, respectively, 4 years later. In contrast, daily reactivity to stress with negative affect did not mediate the prospective relation between SC perfectionism and anhedonic depressive symptoms. Findings also demonstrated that higher mean levels of daily stress did not mediate the relationship between SC perfectionism and depressive and anxious symptoms 4 years later. These findings highlight the importance of targeting enduring heightened stress reactivity in order to reduce SC perfectionists' vulnerability to depressive and anxious symptoms over the long term. PMID:26191980

  10. Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity.

    PubMed

    He, Ling-jie; Liu, Nan; Cheng, Tian-lin; Chen, Xiao-jing; Li, Yi-ding; Shu, You-sheng; Qiu, Zi-long; Zhang, Xiao-hui

    2014-01-01

    Mutations in the X-linked gene encoding the transcriptional modulator methyl-CpG-binding protein 2 (MeCP2) impair postnatal development of the brain. Here we use neuronal-type specific gene deletion in mice to show that conditional Mecp2 deletion in GABAergic parvalbumin-expressing (PV) cells (PV-Mecp2(-/y)) does not cause most Rett-syndrome-like behaviours, but completely abolishes experience-dependent critical period plasticity of primary visual cortex (V1) that develops normal visual functions. However, selective loss of Mecp2 in GABAergic somatostatin-expressing cells or glutamatergic pyramidal cells does not affect the critical period plasticity. MeCP2-deficient PV cells exhibit high intrinsic excitability, selectively reduced efficacy of recurrent excitatory synapses in V1 layer 4 circuits, and decreased evoked visual responses in vivo. Enhancing cortical gamma-aminobutyric acid (GABA) inhibition with diazepam infusion can restore critical period plasticity in both young and adult PV-Mecp2(-/y) mice. Thus, MeCP2 expression in inhibitory PV cells during the critical period is essential for local circuit functions underlying experience-dependent cortical plasticity. PMID:25297674

  11. ATLAS Detector Performance status, improvements during winter 2010 shutdown and results with initial 2011 data taking period

    NASA Astrophysics Data System (ADS)

    Benekos, Nektarios Chr

    2012-02-01

    After the successful 2010 LHC run, where the ATLAS detector recorder 45pb-1 of proton-proton collision data with 93.6% data taking efficiency and during the recent LHC shutdown period, ATLAS performed vital maintenance and improvements on the various sub-detectors. Maintenance on the Muon Spectrometer included repairs on the readout system as well as updates and leak checks in the gas system. Six TGC chambers have been also replaced. For the Calorimeters, repairs were carried out on the front-end electronics and power supplies to recover detector coverage that have been lost since the last maintenance period. Repairs were also performed on the Inner Detector, but at a smaller scale. Finally the ALFA luminosity detector was installed along the beam line and is being commissioned. This talk summarizes the above repairs and their expected improvement for physics performance and reliability of the ATLAS for the 2011 LHC run.

  12. Results of the Tiegcm and the Peak Height Disturbance Models on the Occasion of Selected Magnetically Disturbed Periods

    NASA Astrophysics Data System (ADS)

    Altadill, David; Blanch, Estefania; Marsal, Santiago

    The AMPERE-driven Thermosphere-Ionosphere Electrodynamics General Circulation Model (TIEGCM) and the ionospheric peak height disturbances model have been used to analyze the ionospheric effects at global and local scales. The AMPERE-driven TIEGCM has been newly improved with auroral conductivities consistent with field-aligned currents provided by the AMPERE satellite mission. Both models are validated using real ionosonde and ground magnetic data on the occasion of recent magnetically active periods.

  13. PG 0308 + 096 and PG 1026 + 002 - Two new short period binary stars resulting from common-envelope evolution

    NASA Technical Reports Server (NTRS)

    Saffer, Rex A.; Wade, Richard A.; Liebert, James; Green, Richard F.; Sion, Edward M.; Bechtold, J.; Foss, Diana; Kidder, K.

    1993-01-01

    Ultraviolet spectroscopy, optical spectroscopy, and spectrophotometry have been used to study the excess UV stars PG 0308 + 096 and PG 1026 + 002. Both objects are short-period binary systems, each containing a DA white dwarf star and a dM star. Orbital periods of approximately 0.284 day for PG 0308 + 096, and aproximately 0.597 day for PG 1026, have been found by spectroscopic analysis of the H-alpha emission line. Ly-alpha and Balmer line profile fitting were used to estimate the mass of white dwarf stars; mass estimates for the dM stars are based on their spectral types. The orbital inclinations are derived from these masses, the periods, and amplitudes of the H-alpha radial velocity curves. The equivalent width of the H-alpha emission line, in each binary system, varies with the orbital phase in such a manner as to imply that it arises, in large part at least, from the hemisphere of the M star that faces the white dwarf star.

  14. Compensatory orthodontic treatment for maxillary deficiency: a 4-year follow-up.

    PubMed

    Silveira, Giordani Santos; de Gauw, Johnny Holanda; Motta, Alexandre Trindade; Mucha, José Nelson

    2014-08-01

    In this article, we report the orthodontic treatment of a boy (age 12 years 9 months) who had a midface deficiency, a concave facial profile with maxillary retrusion, a complete crossbite (anterior and posterior), and the maxillary right canine retained in the alveolus. Rapid maxillary expansion was performed followed by complete orthodontic treatment with fixed appliances combined with Class III elastics and anterior vertical elastics. Time was allowed to elapse until growth was virtually over before removing the fixed appliances (at age 18 years 4 months), and no retainer of any type was used. As a result of treatment, significant improvement was noted in his facial appearance, with a proper maxillomandibular relationship, total correction of the maxillary atresia, and satisfactory overjet and overbite. The results remained stable at the 4-year follow-up. Therefore, it can be argued that the use of Class III elastics combined with rapid maxillary expansion has a beneficial effect in the treatment of transverse and sagittal maxillary deficiency in growing patients. Excellence in how the treatment was finished and discontinuation of treatment and control in the final stages of growth contributed to the stability of the final results. PMID:25085306

  15. Observations of Non-Methane Hydrocarbons Over India During the Asian Summer Monsoon Period: Results from CARIBIC

    NASA Astrophysics Data System (ADS)

    Baker, A. K.; Schuck, T. J.; Slemr, F.; Brenninkmeijer, C. A.

    2008-12-01

    The CARIBIC project (Civil Aircraft for the Regular Investigation of the Atmosphere Based on an Instrument Container, www.caribic-atmospheric.com) involves the monthly deployment of an instrument container equipped to make atmospheric measurements from onboard a long-range commercial airliner. Since December 2004, flights for the second phase of CARIBIC have been aboard a Lufthansa Airbus A340-600 traveling between Frankfurt, Germany and destinations in Asia, North America and South America. The instrument package housed in the container (1.5 ton) is fully automated and during each monthly set of flights carries out a variety of real-time trace gas and aerosol measurements, and also collects 28 air samples, which are analyzed upon return to the laboratory. Routine measurements made from the sampling flasks include non-methane hydrocarbon (NMHC) analysis, and these measurements provide the basis for the data presented here. Between April and September of 2008, the container was deployed monthly on two sequential roundtrip flights between Frankfurt and Chennai, India. To achieve greater resolution, air samples were collected only on the first of the roundtrip flights, with 14 samples collected on the flight to Chennai and 14 collected on the return. These flights provided the opportunity to study the composition of the upper troposphere in this region during the Asian summer monsoon period (typically June-September), which is characterized by anticyclonic circulation in the upper troposphere coupled with deep convection. Samples collected during the monsoon period exhibit elevated levels of NMHCs relative to samples collected outside of the monsoon period, with enhancements in ethyne and benzene being more substantial than enhancements in the alkanes. Enhanced mixing ratios are observed between 15N and 40N, and correspond to enhancements in other trace gases, namely methane and CO. Ethyne in particular is strongly correlated with both methane and CO in this region

  16. Results of Groundwater Monitoring for the 183-H Solar Evaporation Basins Reporting Period: July-December 2006

    SciTech Connect

    Hartman, Mary J.

    2007-04-10

    This is one of a series of reports on Resource Conservation and Recovery Act monitoring at the 183 H basins. It fulfills a requirement of WAC 173-303-645(11)(g) to report twice each year on the effectiveness of the corrective action program. This report covers the period from July through December 2006. The current objective of corrective action monitoring is simply to track trends. Although there is short-term variability in contaminant concentrations, trends over the past 10 years are downward. The current RCRA permit and monitoring plan remain adequate for the objective of tracking trends.

  17. A Patient With Parenteral Nutrition-Dependent Short Bowel Syndrome and Cardiovascular Disease With 4-Year Exposure to Teduglutide.

    PubMed

    Compher, Charlene; Levinson, Katherine Boothe; Cambor, Carolyn L; Stoner, Nancy; Boullata, Joseph I; Piarulli, Amanda; Kinosian, Bruce

    2016-07-01

    Clinical trials of the glucagon-like peptide 2 analogue teduglutide resulted in approval of the drug by the Food and Drug Administration in 2012 as a treatment for parenteral nutrition-dependent short bowel syndrome in adults. This report presents the case study of a man with short bowel syndrome caused by portal vein thrombosis who had 4 years exposure to the drug at the time of his death due to cardiovascular disease. PMID:25567782

  18. Inverse Planned High-Dose-Rate Brachytherapy for Locoregionally Advanced Cervical Cancer: 4-Year Outcomes

    SciTech Connect

    Tinkle, Christopher L.; Weinberg, Vivian; Chen, Lee-May; Littell, Ramey; Cunha, J. Adam M.; Sethi, Rajni A.; Chan, John K.; Hsu, I-Chow

    2015-08-01

    Purpose: Evaluate the efficacy and toxicity of image guided brachytherapy using inverse planning simulated annealing (IPSA) high-dose-rate brachytherapy (HDRB) boost for locoregionally advanced cervical cancer. Methods and Materials: From December 2003 through September 2009, 111 patients with primary cervical cancer were treated definitively with IPSA-planned HDRB boost (28 Gy in 4 fractions) after external radiation at our institution. We performed a retrospective review of our experience using image guided brachytherapy. Of the patients, 70% had a tumor size >4 cm, 38% had regional nodal disease, and 15% had clinically evident distant metastasis, including nonregional nodal disease, at the time of diagnosis. Surgical staging involving pelvic lymph node dissection was performed in 15% of patients, and 93% received concurrent cisplatin-based chemotherapy. Toxicities are reported according to the Common Terminology Criteria for Adverse Events version 4.0 guidelines. Results: With a median follow-up time of 42 months (range, 3-84 months), no acute or late toxicities of grade 4 or higher were observed, and grade 3 toxicities (both acute and late) developed in 8 patients (1 constitutional, 1 hematologic, 2 genitourinary, 4 gastrointestinal). The 4-year Kaplan-Meier estimate of late grade 3 toxicity was 8%. Local recurrence developed in 5 patients (4 to 9 months after HDRB), regional recurrence in 3 (6, 16, and 72 months after HDRB), and locoregional recurrence in 1 (4 months after HDR boost). The 4-year estimates of local, locoregional, and distant control of disease were 94.0%, 91.9%, and 69.1%, respectively. The overall and disease-free survival rates at 4 years were 64.3% (95% confidence interval [CI] of 54%-73%) and 61.0% (95% CI, 51%-70%), respectively. Conclusions: Definitive radiation by use of inverse planned HDRB boost for locoregionally advanced cervical cancer is well tolerated and achieves excellent local control of disease. However, overall

  19. Rapid Buildup of Brain White Matter Hyperintensities Over 4 Years Linked to Ambulatory Blood Pressure, Mobility, Cognition, and Depression in Old Persons

    PubMed Central

    2013-01-01

    Background. Brain white matter hyperintensities (WMH) are associated with functional decline in older people. We performed a 4-year cohort study examining progression of WMH, its effects on mobility, cognition, and depression with the role of clinic and 24-hour ambulatory systolic blood pressure as a predisposing factor. Methods. Ninety-nine subjects, 75–89 years were stratified by age and mobility, with the 67 completing 4-years comprising the cohort. Mobility, cognition, depressive symptoms, and ambulatory blood pressure were assessed, and WMH volumes were determined by quantitative analysis of magnetic resonance images. Results. WMH increased from 0.99±0.98% of intracranial cavity volume at baseline to 1.47±1.2% at 2 years and 1.74±1.30% after 4 years. Baseline WMH was associated with 4-year WMH (p < .0001), explaining 83% of variability. Small, but consistent mobility decrements and some evidence of cognitive decline were noted over 4 years. Regression analyses using baseline and 4-year WMHs were associated with three of five mobility measures, two of four cognitive measures and the depression scale, all performed at 4 years. Increases in ambulatory systolic blood pressure but not clinic systolic blood pressure during the initial 2 years were associated with greater WMH accrual during those years, while ambulatory systolic blood pressure was related to WMH at 4 years. Conclusion. Declines in mobility, cognition, and depressive symptoms were related to WMH accrual over 4 years, and WMH was related to out-of-office blood pressure. This suggests that prevention of microvascular disease, even in asymptomatic older persons, is fundamental for preserving function. There may be value in tighter 24-hour blood pressure control in older persons although this requires further investigation. PMID:23766429

  20. The effects of a 4-year program promoting bicycle helmet use among children in Quebec.

    PubMed Central

    Farley, C; Haddad, S; Brown, B

    1996-01-01

    OBJECTIVES. This study assessed the effectiveness of a 4-year program of bicycle helmet promotion that targeted elementary school children in one region of Quebec. The program revolved primarily around persuasive communication and community organization, combining standard educational activities and activities to facilitate helmet acquisition and use. METHODS. Helmet use was compared between more than 8000 young cyclists in municipalities exposed or not exposed to the program. Factors influencing helmet use were controlled through the use of multivariate analyses. RESULTS. Helmet use increased from 1.3% before program implementation to 33% in 1993. The program was clearly effective in most cycling circumstances and for various groups of children. However, the benefits of the program were unequally distributed; the program was one third as effective in poorer municipalities as in "average-rich" ones. CONCLUSIONS. This community-based program that combined various types of activities appeared to be effective. New intervention models are needed to ensure an equitable distribution of benefits. PMID:8561241

  1. Visual access trumps gender in 3- and 4-year-old children's endorsement of testimony.

    PubMed

    Terrier, Nathalie; Bernard, Stéphane; Mercier, Hugo; Clément, Fabrice

    2016-06-01

    Several studies have investigated how preschoolers weigh social cues against epistemic cues when taking testimony into account. For instance, one study showed that 4- and 5-year-olds preferred to endorse the testimony of an informant who had the same gender as the children; by contrast, when the gender cue conflicted with an epistemic cue-past reliability-the latter trumped the former. None of the previous studies, however, has shown that 3-year-olds can prioritize an epistemic cue over a social cue. In Experiment 1, we offer the first demonstration that 3-year-olds favor testimony from a same-gender informant in the absence of other cues. In Experiments 2 and 3, an epistemic cue-visual access-was introduced. In those experiments, 3- and 4-year-olds endorsed the testimony of the informant with visual access regardless of whether it was a same-gender informant (Experiment 3) or a different-gender informant (Experiment 2). These results demonstrate that 3-year-olds are able to give more weight to an epistemic cue than to a social cue when evaluating testimony. PMID:26925718

  2. 42 CFR 476.96 - Review period and reopening of initial denial determinations and changes as a result of DRG...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... determinations and changes as a result of DRG validations. 476.96 Section 476.96 Public Health CENTERS FOR... initial denial determinations and changes as a result of DRG validations. (a) General timeframe. A QIO or... initial denial determination or a change as a result of a DRG validation. (b) Extended timeframes. (1)...

  3. 42 CFR 476.96 - Review period and reopening of initial denial determinations and changes as a result of DRG...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... determinations and changes as a result of DRG validations. 476.96 Section 476.96 Public Health CENTERS FOR... initial denial determinations and changes as a result of DRG validations. (a) General timeframe. A QIO or... initial denial determination or a change as a result of a DRG validation. (b) Extended timeframes. (1)...

  4. Evolution of T1 black holes in patients with multiple sclerosis imaged monthly for 4 years.

    PubMed

    Bagnato, Francesca; Jeffries, Neal; Richert, Nancy D; Stone, Roger D; Ohayon, Joan M; McFarland, Henry F; Frank, Joseph A

    2003-08-01

    T1 black holes (BHs) on MRIs may represent either areas of oedema or axonal loss in patients with multiple sclerosis. BHs begin as contrast enhancing lesions (CELs) and evolve differently from patient to patient, and within the same patient over time. We analysed BHs formation over a 4-year period. Forty-eight monthly MRIs of nine non-treated multiple sclerosis patients were evaluated for numbers of CELs and BHs. A BH was defined as a hypointense lesion on a T1 pre-contrast image that coincided with a region of high signal intensity on the T2-weighted images. A BH was considered as acute (ABH) when it occurred coincidently with the presence of enhancement and as persisting (PBH) when present after the cessation of enhancement. The present study aimed to analyse: (i) the incidence of CELs and new PBHs, and the accumulation of PBHs; (ii) the relationship between the quantity of the CELs in a given month and the likelihood of accumulating PBHs in the subsequent month; and (iii) the relationship between the duration of CELs and PBHs. Pitman's correlation test evaluated the effect of time on either the increase of CELs and new PBHs or the accumulation of PBHs, while a multiple logistic regression analysis evaluated the relationship between progression of time and CELs, and the increase of PBHs in a multivariate model. The relationship between the enhancing lesions duration and the PBHs duration, or the time to revert back to an isointense lesion was analysed using Kaplan-Meier survival models. PBHs accumulated (P < 0.001) in all patients, but the formation of new PBHs increased in four patients (P < or = 0.007) in conjunction with an increase in either the quantity of CELs (P < 0.001, for two patients) or the proportion of CELs turning into PBHs (P < or = 0.02, for two patients). Logistic regression analysis showed that neither progression of time nor the number of CELs in a given month were able to predict the probability of increasing the number of PBHs in the

  5. Shifting gears higher - digital slides in graduate education - 4 years experience at Semmelweis University

    PubMed Central

    2010-01-01

    Background The spreading of whole slide imaging or digital slide systems in pathology as an innovative technique seems to be unstoppable. Successful introduction of digital slides in education has played a crucial role to reach this level of acceptance. Practically speaking there is no university institute where digital materials are not built into pathology education. At the 1st. Department of Pathology and Experimental Cancer Research, Semmelweis University optical microscopes have been replaced and for four years only digital slides have been used in education. The aim of this paper is to summarize our experiences gathered with the installation of a fully digitized histology lab for graduate education. Methods We have installed a digital histology lab with 40 PCs, two slide servers - one for internal use and one with external internet access. We have digitized hundreds of slides and after 4 years we use a set of 126 slides during the pathology course. A Student satisfaction questionnaire and a Tutor satisfaction questionnaire have been designed, both to be completed voluntarily to have feed back from the users. The page load statistics of the external slide server were evaluated. Results The digital histology lab served ~900 students and ~1600 hours of histology practice. The questionnaires revealed high satisfaction with digital slides. The results also emphasize the importance of the tutors' attitude towards digital microscopy as a factor influencing the students' satisfaction. The constantly growing number of page downloads from the external server confirms this satisfaction and the acceptance of digital slides. Conclusions We are confident, and have showed as well, that digital slides have got numerous advantages over optical slides and are more suitable in education. PMID:21092205

  6. Endometrial intraepithelial neoplasia terminology in practice: 4-year experience at a single institution.

    PubMed

    Kane, Sarah E; Hecht, Jonathan L

    2012-03-01

    An alternative WHO classification system for endometrial precancers and hyperplasia separates a lesion called endometrial intraepithelial neoplasia (EIN) from diffuse hormonal effects and cancer, resulting in a 3-category system. EIN is a localized lesion with objective histologic criteria, characterized by monoclonal growth of mutated cells, and associated with a 45-fold elevated cancer risk. This study summarizes our department's experience with EIN diagnoses in the 4 years since conversion to the new terminology. We identified all reports from endometrial samples diagnosed as EIN or including the terms "gland crowding" or "atypia" since conversion and obtained follow-up information from subsequent pathology specimens or clinic notes (82%). The diagnoses were reported by a mixture of pathologists, the majority of whom are not subspecialized to gynecologic pathology and the slides were not reviewed. Overall, 17.1% of women with EIN had carcinoma and 34.9% had either carcinoma or persistent EIN. The proportion of women with EIN or cancer on follow-up did not trend with years since adoption of EIN terminology. The median age at the time of diagnosis was 55 years in an overall population of women who underwent sampling at a median age of 47 years. The median follow-up time was 4 months. All cancers were of endometrioid histology; all but 2 were International Federation of Gynecology and Obstetrics grade 1. In comparison with a previous reproducibility study among expert pathologists on a comparable population from our department, these results for general pathologists show a higher false positive rate for subsequent cancer. PMID:22317874

  7. Predictors of Funded Scholarly Activity at 4-Year, Non-Doctoral Colleges and Universities

    ERIC Educational Resources Information Center

    Edwards, Maria Montoro

    2010-01-01

    This study seeks to develop a model of institutional supports necessary for faculty to succeed as funded scholars at 4-year non-doctoral colleges and universities. Research was conducted using secondary data analysis on a pre-existing, cross-sectional database from the 2004 National Study of Postsecondary Faculty. Expectancy theory was used as the…

  8. Institutional Characteristics and Student Retention in Public 4-Year Colleges and Universities

    ERIC Educational Resources Information Center

    Marsh, Gregory

    2014-01-01

    The purpose of this study was to determine the relative importance of specific student and institutional factors and characteristics on the retention of students at public, 4-year colleges and universities in the United States based on aggregate student cohort and institutional data. The overriding goal of this research was to identify any…

  9. My Body. Developing an Early Interest in Science: A Preschool Science Curriculum. (4-Year-Olds).

    ERIC Educational Resources Information Center

    Summer, Gail L.; Giovannini, Kathleen

    This teaching guide on the body for 4-year-olds is based on a modification of the "Plan, Do, Review" approach to education devised by High Scope in Ypsilanti, Michigan. First implemented as an outreach early childhood program in North Carolina, the science activities described in this guide can be adapted to various early childhood environments.…

  10. Comparing Student Performance and Growth in 2- and 4-Year Institutions.

    ERIC Educational Resources Information Center

    Strauss, Linda C.; Volkwein, J. Fredericks

    2002-01-01

    Examined the organizational characteristics of 51 higher education institutions in relationship to student performance and growth. Findings included that the different 2-year and 4-year campus missions do exert significantly different influences on undergraduate GPA and self-reported intellectual growth, with students at 2-year institutions…

  11. Transfer Rates of Texas Hispanic Community College Students to 4-Year Institutions: Selected Institutional Factors

    ERIC Educational Resources Information Center

    Klement, Emily Conrady

    2012-01-01

    The purpose of this non-experimental, quantitative study was to determine how well selected institutional characteristics explain the variance in Hispanic community college students' transfer rates to 4-year institutions. Due to the rapidly growing Texas Hispanic population, understanding challenges to their educational attainment has become…

  12. Trends in the Educational Experience of 3- to 4-Year-Old Children.

    ERIC Educational Resources Information Center

    Kaufman, Phillip; And Others

    Using data from the Census Bureau's 1991 Current Population Survey and the National Household Education Survey, this study examined the trends in nursery school enrollment of 3- and 4-year-old children from 1975 to 1990. Factors examined included number of enrollments in nursery schools, race and ethnicity of the students, students' family income,…

  13. Vowel Confusion Patterns in Adults during Initial 4 Years of Implant Use

    ERIC Educational Resources Information Center

    Vaalimaa, Taina T.; Sorri, Martti J.; Laitakari, Jaakko; Sivonen, Ville; Muhli, Arto

    2011-01-01

    This study investigated adult cochlear implant users' (n == 39) vowel recognition and confusions by an open-set syllable test during 4 years of implant use, in a prospective repeated-measures design. Subjects' responses were coded for phoneme errors and estimated by the generalized mixed model. Improvement in overall vowel recognition was highest…

  14. Transfer between Community Colleges and 4-Year Colleges: The All-American Game

    ERIC Educational Resources Information Center

    Hagedorn, Linda Serra; Moon, Hye Sun; Cypers, Scott; Maxwell, William E.; Lester, Jaime

    2006-01-01

    In this article, the authors introduce a novel way, using the metaphor of a baseball game, to evaluate and measure community college student progress for those whose stated goal is to transfer to a 4-year institution and, ultimately, earn a bachelor's degree. The proposed framework of "the Transfer Game" is an outgrowth of the Transfer and…

  15. Title VI-A. Higher Education Act in New York State. 4-Year Report.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Office of Higher Education Planning.

    Title VI-A provides matching federal funds for the purchase of college and university laboratory and audiovisual equipment, closed-circuit television equipment and classroom materials related to the improvement of undergraduate education. This report presents case studies of 12 institutions which obtained Title VI-A funds in the past 4 years. The…

  16. Universal SAT® Policy Boosts 4-Year College Enrollment. Info to Go™ 2015-1

    ERIC Educational Resources Information Center

    Hurwitz, Michael; Smith, Jonathan; Niu, Sunny; Howell, Jessica

    2015-01-01

    Maine replaced its existing high school statewide assessment with the SAT® and administered the exam to almost all public high school juniors. A primary goal of this policy change was to increase 4-year college enrollment by public school students in Maine. This brief report provides an overview of the data, research methodology employed, as well…

  17. Social Context Effects in 2- and 4-Year-Olds' Selective versus Faithful Imitation

    ERIC Educational Resources Information Center

    Yu, Yue; Kushnir, Tamar

    2014-01-01

    This study asked whether children's tendency to imitate selectively (ignore causally unnecessary actions) versus faithfully ("overimitate" causally unnecessary actions) varies across ages and social contexts. In the first experiment, 2-year-olds and 4-year-olds were randomly assigned to play 1 of 3 prior games with a demonstrator: a…

  18. Through Another's Eyes: Elements in the Eyes of a 4-Year-Old

    ERIC Educational Resources Information Center

    Hu, Xuan

    2004-01-01

    My husband, who is a scientist, often brings home different scientific journals and magazines to read, and my 4-year-old son, Nicholas J. Hu, likes to flip through them. A recent issue of Chemical and Engineering News (September, 2003) caught his interest more than usual because there were stories of different elements. Nicholas has been able to…

  19. A Gender Comparison of the Cooperation of 4-Year-Old Children in Classroom Activity Centers

    ERIC Educational Resources Information Center

    Anderson, Genan T.; Hilton, Sterling C.; Wouden-Miller, Melissa

    2003-01-01

    This study examined the proportion of cooperative play in 4-year-old children across centers (housekeeping, block, manipulative, and computer) and gender in a natural classroom setting. Eighty-four white, middle-income children (41 boys and 43 girls, mean age = 55 months) were videotaped during free-play for 30 minutes per day for four weeks in…

  20. Collaboration between 3- and 4-Year-Olds in Self-Initiated Play on Instruments

    ERIC Educational Resources Information Center

    Young, Susan

    2008-01-01

    This article reports on a study of collaborative music-making on instruments among 3- and 4-year-old children. An area equipped with musical instruments was provided as a free-choice play option in an early childhood setting and a fixed camera recorded the children's play continuously during a number of visits. From the total 17 h of data five…

  1. Examining the Role of Advanced Placement[R] Exam Participation in 4-Year College Enrollment

    ERIC Educational Resources Information Center

    Chajewski, Michael; Mattern, Krista D.; Shaw, Emily J.

    2011-01-01

    The purpose of the current study was to examine the relationship between Advanced Placement (AP) exam participation and enrollment in a 4-year postsecondary institution. A positive relationship was expected given that the primary purpose of offering AP courses is to allow students to engage in college-level academic work while in high school, and…

  2. Measuring Implicit Attitudes of 4-Year-Olds: The Preschool Implicit Association Test

    ERIC Educational Resources Information Center

    Cvencek, Dario; Greenwald, Anthony G.; Meltzoff, Andrew N.

    2011-01-01

    The Preschool Implicit Association Test (PSIAT) is an adaptation of an established social cognition measure (IAT) for use with preschool children. Two studies with 4-year-olds found that the PSIAT was effective in evaluating (a) attitudes toward commonly liked objects ("flowers"="good") and (b) gender attitudes ("girl"="good" or "boy"="good"). The…

  3. Creppy Crawlies. Developing an Early Interest in Science: A Preschool Science Curriculum. (4-Year-Olds).

    ERIC Educational Resources Information Center

    Summer, Gail L.; Giovannini, Kathleen

    This science teaching guide on insects and animals for 4-year-old children is based on a modification of the "Plan, Do, Review" approach to education devised by High Scope in Ypsilanti, Michigan. First implemented as an outreach early childhood program in North Carolina, the science activities described in this guide can be adapted to various…

  4. Preventing and Responding to Bullying: An Elementary School's 4-Year Journey

    ERIC Educational Resources Information Center

    McCormac, Mary E.

    2015-01-01

    Bullying continues to be a pervasive problem in schools and requires a schoolwide approach. This article describes the action research process used to examine the impact of a 4-year, K-5 school bullying prevention and intervention. The school counselors collaborated with students, staff, and parents to implement the program, and collected and…

  5. Relations of Television Viewing and Reading: Findings from a 4-Year Longitudinal Study

    ERIC Educational Resources Information Center

    Ennemoser, Marco; Schneider, Wolfgang

    2007-01-01

    This longitudinal study explored the long-term effects of television viewing on the development of children's reading competencies. Among 2 cohorts of German children (N[subscript 1] = 165, N[subscript 2] = 167), measures of television viewing were collected over 4 years, and tests of reading speed and reading comprehension were administered…

  6. Markers for Persistent Specific Expressive Language Delay in 3-4-Year-Olds

    ERIC Educational Resources Information Center

    Everitt, Andrea; Hannaford, Philip; Conti-Ramsden, Gina

    2013-01-01

    Background: Identifying 3-4-year-olds who are most at risk of persisting language difficulties, and possibly specific language impairment (SLI), is difficult due to the natural variation of language in young children. In older children, markers for SLI have been identified that differentiate between children with and without SLI. It is not known…

  7. Overweight among Low-Income Texas Preschoolers Aged 2 to 4 Years

    ERIC Educational Resources Information Center

    Lewis, Kayan L.; Castrucci, Brian C.; Gossman, Ginger; Mirchandani, Gita; Sayegh, M. Aaron; Moehlman, Clint; Van Eck, Mary; Petrilli, Kimberly

    2010-01-01

    Objective: Determine child/maternal factors associated with overweight among 2- to 4-year-olds enrolled in the Texas Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). Design: Matched child and maternal data collected by self-report of the mother during WIC certification. These data were extracted from existing…

  8. Dietary fat types and 4-year cognitive change in community-dwelling older women

    PubMed Central

    Okereke, Olivia I.; Rosner, Bernard A.; Kim, Dae H.; Kang, Jae H.; Cook, Nancy R.; Manson, JoAnn E.; Buring, Julie E.; Willett, Walter C.; Grodstein, Francine

    2012-01-01

    Objective To relate dietary fat types to cognitive change in healthy community-based elders. Methods Among 6,183 older participants in the Women’s Health Study, we related intake of major fatty acids (FAs) (saturated [SFA], mono-unsaturated [MUFA], total poly-unsaturated [PUFA], trans-unsaturated) to late-life cognitive trajectory. Serial cognitive testing, conducted over 4 years, began 5 years post-dietary assessment. Primary outcomes were global cognition (averaging tests of general cognition, verbal memory and semantic fluency) and verbal memory (averaging tests of recall). We used analyses of response profiles and logistic regression to estimate multivariable-adjusted differences in cognitive trajectory and risk of worst cognitive change (worst 10%) by fat intake. Results Higher SFA intake was associated with worse global cognitive (p-linear-trend=0.008) and verbal memory (p-linear-trend=0.01) trajectories. There was a higher risk of worst cognitive change, comparing highest vs. lowest SFA quintiles: the multivariable-adjusted odds ratio (OR) (95% confidence interval, CI) was 1.64 (1.04,2.58) for global cognition and 1.65 (1.04,2.61) for verbal memory. By contrast, higher MUFA intake was related to better global cognitive (p-linear-trend<0.001) and verbal memory (p-linear-trend=0.009) trajectories, and lower OR (95% CI) of worst cognitive change in global cognition (0.52 [0.31,0.88]) and verbal memory (0.56 [0.34,0.94]). Total fat, PUFA, and trans fat intakes were not associated with cognitive trajectory. Interpretation Higher SFA intake was associated with worse global cognitive and verbal memory trajectories, while higher MUFA intake was related to better trajectories. Thus, different consumption levels of the major specific fat types, rather than total fat intake itself, appeared to influence cognitive aging. PMID:22605573

  9. Drinking Consequences and Subsequent Drinking in College Students Over 4 Years

    PubMed Central

    Martinez, Julia A.; Sher, Kenneth J.; Wood, Phillip K.

    2015-01-01

    There is some evidence that college student drinkers may continue drinking in the face of adverse consequences. We examined 2 hypotheses: (a) that this seemingly pathological behavior is a phenomenon of university life, occurring with consistency throughout the entirety of college, and (b) that individuals accumulate these consequences over multiple semesters in college. A sample of 3,720 students from a large Midwestern university was asked to complete surveys the summer before college and every semester thereafter for 4 years. Results showed that certain drinking-related consequences (e.g., blackouts, regretted sexual experiences) consistently predicted continued frequent heavy drinking in the following semester, even after controlling for sex, race, age, and previous-semester frequent heavy drinking (range of odds ratio = 1.17 to 1.45 across semesters, p < .01). Such potent consequences may predict subsequent drinking for a number of possible reasons that may be examined and addressed as they would pertain to specific protective behavioral strategy-related and cognitive interventions. Furthermore, consequences were accumulated over multiple semesters by notable proportions of students. For example, 13.8% of students reported blacking out 5 time-points or more—describing a full half or more of their college careers. Experimental studies which aim to modify students’ perceptions of norms associated with these consequences may aid in developing interventions to reduce the burden of harm to students. In the broader context, and given the prevalence of students’ accumulation of consequences, future study might aim to determine how and in what ways these findings describe either pathological or normative processes. PMID:25528051

  10. Air Pollution and Acute Respiratory Infections Among Children 0–4 Years of Age: An 18-Year Time-Series Study

    PubMed Central

    Darrow, Lyndsey A.; Klein, Mitchel; Flanders, W. Dana; Mulholland, James A.; Tolbert, Paige E.; Strickland, Matthew J.

    2014-01-01

    Upper and lower respiratory infections are common in early childhood and may be exacerbated by air pollution. We investigated short-term changes in ambient air pollutant concentrations, including speciated particulate matter less than 2.5 μm in diameter (PM2.5), in relation to emergency department (ED) visits for respiratory infections in young children. Daily counts of ED visits for bronchitis and bronchiolitis (n = 80,399), pneumonia (n = 63,359), and upper respiratory infection (URI) (n = 359,246) among children 0–4 years of age were collected from hospitals in the Atlanta, Georgia, area for the period 1993–2010. Daily pollutant measurements were combined across monitoring stations using population weighting. In Poisson generalized linear models, 3-day moving average concentrations of ozone, nitrogen dioxide, and the organic carbon fraction of particulate matter less than 2.5 μm in diameter (PM2.5) were associated with ED visits for pneumonia and URI. Ozone associations were strongest and were observed at low (cold-season) concentrations; a 1–interquartile range increase predicted a 4% increase (95% confidence interval: 2%, 6%) in visits for URI and an 8% increase (95% confidence interval: 4%, 13%) in visits for pneumonia. Rate ratios tended to be higher in the 1- to 4-year age group compared with infants. Results suggest that primary traffic pollutants, ozone, and the organic carbon fraction of PM2.5 exacerbate upper and lower respiratory infections in early life, and that the carbon fraction of PM2.5 is a particularly harmful component of the ambient particulate matter mixture. PMID:25324558

  11. Air pollution and acute respiratory infections among children 0-4 years of age: an 18-year time-series study.

    PubMed

    Darrow, Lyndsey A; Klein, Mitchel; Flanders, W Dana; Mulholland, James A; Tolbert, Paige E; Strickland, Matthew J

    2014-11-15

    Upper and lower respiratory infections are common in early childhood and may be exacerbated by air pollution. We investigated short-term changes in ambient air pollutant concentrations, including speciated particulate matter less than 2.5 μm in diameter (PM2.5), in relation to emergency department (ED) visits for respiratory infections in young children. Daily counts of ED visits for bronchitis and bronchiolitis (n = 80,399), pneumonia (n = 63,359), and upper respiratory infection (URI) (n = 359,246) among children 0-4 years of age were collected from hospitals in the Atlanta, Georgia, area for the period 1993-2010. Daily pollutant measurements were combined across monitoring stations using population weighting. In Poisson generalized linear models, 3-day moving average concentrations of ozone, nitrogen dioxide, and the organic carbon fraction of particulate matter less than 2.5 μm in diameter (PM2.5) were associated with ED visits for pneumonia and URI. Ozone associations were strongest and were observed at low (cold-season) concentrations; a 1-interquartile range increase predicted a 4% increase (95% confidence interval: 2%, 6%) in visits for URI and an 8% increase (95% confidence interval: 4%, 13%) in visits for pneumonia. Rate ratios tended to be higher in the 1- to 4-year age group compared with infants. Results suggest that primary traffic pollutants, ozone, and the organic carbon fraction of PM2.5 exacerbate upper and lower respiratory infections in early life, and that the carbon fraction of PM2.5 is a particularly harmful component of the ambient particulate matter mixture. PMID:25324558

  12. Implementation of basic quality control tests for malaria medicines in Amazon Basin countries: results for the 2005–2010 period

    PubMed Central

    2012-01-01

    Background Ensuring the quality of malaria medicines is crucial in working toward malaria control and eventual elimination. Unlike other validated tests that can assess all critical quality attributes, which is the standard for determining the quality of medicines, basic tests are significantly less expensive, faster, and require less skilled labour; yet, these tests provide reproducible data and information on several critical quality attributes, such as identity, purity, content, and disintegration. Visual and physical inspection also provides valuable information about the manufacturing and the labelling of medicines, and in many cases this inspection is sufficient to detect counterfeit medicines. The Promoting the Quality of Medicines (PQM) programme has provided technical assistance to Amazon Malaria Initiative (AMI) countries to implement the use of basic tests as a key screening mechanism to assess the quality of malaria medicines available to patients in decentralized regions. Methods Trained personnel from the National Malaria Control Programmes (NMCPs), often in collaboration with country’s Official Medicine Control Laboratory (OMCL), developed country- specific protocols that encompassed sampling methods, sample analysis, and data reporting. Sampling sites were selected based on malaria burden, accessibility, and geographical location. Convenience sampling was performed and countries were recommended to store the sampled medicines under conditions that did not compromise their quality. Basic analytical tests, such as disintegration and thin layer chromatography (TLC), were performed utilizing a portable mini-laboratory. Results Results were originally presented at regional meetings in a non-standardized format that lacked relevant medicines information. However, since 2008 information has been submitted utilizing a template specifically developed by PQM for that purpose. From 2005 to 2010, the quality of 1,663 malaria medicines from seven AMI countries

  13. French regional surveillance program of carbapenemase-producing Gram-negative bacilli: results from a 2-year period.

    PubMed

    Pantel, A; Boutet-Dubois, A; Jean-Pierre, H; Marchandin, H; Sotto, A; Lavigne, J-P

    2014-12-01

    In February 2011, the CARB-LR group was created as a sentinel laboratory-based surveillance network to control the emergence of carbapenem-resistant Gram-negative bacilli (CR GNB) in a French Southern Region. We report the epidemiological results of a 2-year study. All the Gram-negative bacilli isolates detected in the different labs (hospital and community settings) of a French Southern Region and with reduced susceptibility to ertapenem and/or imipenem were characterised with regard to antibiotic resistance, bla genes content, repetitive sequence-based polymerase chain reaction (rep-PCR) profiles and multilocus sequence typing (MLST). A total of 221 strains were analysed. Acinetobacter baumannii was the most prevalent carbapenemase-producing bacteria, with a majority of OXA-23 producers (n = 37). One isolate co-produced OXA-23 and OXA-58 enzymes. Klebsiella pneumoniae was the most frequent carbapenemase-producing Enterobacteriaceae (CPE) (OXA-48 producer: n = 29, KPC producer: n = 1), followed by Escherichia coli (OXA-48 producer: n = 8, KPC producer: n = 1) and Enterobacter cloacae (OXA-48 producer, n = 1). One isolate of Pseudomonas aeruginosa produced a VIM-1 carbapenemase. A clonal diversity of carbapenemase-producing K. pneumoniae and E. coli was noted with different MLSTs. On the other hand, almost all OXA-23-producing A. baumannii strains belonged to the widespread ST2/international clone II. The link between the detection of CR GNB and a foreign country was less obvious, suggesting the beginning of a local cross-transmission. The number of CR GNB cases in our French Southern Region has sharply increased very recently due to the diffusion of OXA-48 producers. PMID:25037867

  14. Canadian Sedentary Behaviour Guidelines for the Early Years (aged 0-4 years).

    PubMed

    Tremblay, Mark S; Leblanc, Allana G; Carson, Valerie; Choquette, Louise; Connor Gorber, Sarah; Dillman, Carrie; Duggan, Mary; Gordon, Mary Jane; Hicks, Audrey; Janssen, Ian; Kho, Michelle E; Latimer-Cheung, Amy E; Leblanc, Claire; Murumets, Kelly; Okely, Anthony D; Reilly, John J; Stearns, Jodie A; Timmons, Brian W; Spence, John C

    2012-04-01

    The Canadian Society for Exercise Physiology (CSEP), with assistance from multiple partners, stakeholders, and researchers, developed the first Canadian Sedentary Behaviour Guidelines for the Early Years (aged 0-4 years). These national guidelines are in response to a call from health and health care professionals, child care providers, and fitness practitioners for guidance on sedentary behaviour in the early years. The guideline development process followed the Appraisal of Guidelines for Research Evaluation (AGREE) II framework. The recommendations are informed by evidence from a systematic review that examined the relationships between sedentary behaviour (predominantly screen time) and health indicators (healthy body weight, bone and skeletal health, motor skill development, psychosocial health, cognitive development, and cardio-metabolic disease risk factors) for three age groups (infants aged <1 year; toddlers aged 1-2 years; preschoolers aged 3-4 years). Evidence from the review was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. The new guidelines include a preamble to provide context, followed by the specific recommendations. The final guidelines benefitted from extensive on-line consultations with input from >900 domestic and international stakeholders, end-users, and key informants. The final guidelines state: for healthy growth and development, caregivers should minimize the time infants (aged <1 year), toddlers (aged 1-2 years), and preschoolers (aged 3-4 years) spend being sedentary during waking hours. This includes prolonged sitting or being restrained (e.g., stroller, high chair) for more than 1 h at a time. For those under 2 years, screen time (e.g., TV, computer, electronic games) is not recommended. For children 2-4 years, screen time should be limited to under 1 h per day; less is better. PMID:22448609

  15. Pott puffy tumor in a 4-year-old boy presenting in status epilepticus.

    PubMed

    Strony, Robert J; Dula, David

    2007-11-01

    Pott puffy tumor is an osteomyelitis of the frontal bone with the development of a subperiosteal abscess manifesting as a puffy swelling of the forehead or scalp. It is believed to occur as a complication of frontal sinusitis. The modern antibiotic era has made it a rarely encountered entity. This case describes a 4-year-old boy who presented in status epilepticus secondary to Pott puffy tumor. PMID:18007214

  16. Inflammatory epidermolysis bullosa acquisita in a 4-year-old girl.

    PubMed

    Lazić-Mosler, Elvira; Jukić, Ines Lakoš; Murat-Sušić, Slobodna; Husar, Karmela; Skerlev, Mihael; Bukvić Mokos, Zrinka; Ishii, Norito; Hashimoto, Takashi; Marinović, Branka

    2015-11-01

    This study presents a case of linear immunoglobulin A dermatosis-like epidermolysis bullosa acquisita in a 4-year-old girl showing rapid, widespread and inflammatory skin lesions. The diagnosis was confirmed by histopathology, direct and indirect immunofluorescence, various immunoblotting analyses and enzyme-linked immunosorbent assays. Despite the severe clinical manifestations, the disease was successfully controlled by combination therapy of oral prednisolone and dapsone. PMID:26046385

  17. Efficacy and safety of continuous 4-year telbivudine treatment in patients with chronic hepatitis B

    PubMed Central

    Wang, Y; Thongsawat, S; Gane, E J; Liaw, Y-F; Jia, J; Hou, J; Chan, H L Y; Papatheodoridis, G; Wan, M; Niu, J; Bao, W; Trylesinski, A; Naoumov, N V

    2013-01-01

    In the phase-III GLOBE/015 studies, telbivudine demonstrated superior efficacy vs lamivudine during 2-year treatment in HBeAg-positive and HBeAg-negative chronic hepatitis B (CHB). After completion, 847 patients had an option to continue telbivudine treatment for further 2 years. A total of 596 (70%) of telbivudine-treated patients, who were serum HBV DNA positive or negative and without genotypic resistance to telbivudine at the end of the GLOBE/015 trials, were enrolled into a further 2-year extension study. A group of 502 patients completed 4 years of continuous telbivudine treatment and were included in the telbivudine per-protocol population. Amongst 293 HBeAg-positive patients, 76.2% had undetectable serum HBV DNA and 86.0% had normal serum ALT at the end of 4 years. Notably, the cumulative rate of HBeAg seroconversion was 53.2%. Amongst 209 HBeAg-negative patients, 86.4% had undetectable HBV DNA and 89.6% had normal serum ALT. In patients who had discontinued telbivudine treatment due to HBeAg seroconversion, the HBeAg response was durable in 82% of patients (median 111 weeks of off-treatment follow-up). The cumulative 4-year resistance rate was 10.6% for HBeAg-positive and 10.0% for HBeAg-negative patients. Most adverse events were mild or moderate in severity and transient. Renal function measured by estimated glomerular filtration rate (eGFR) increased by 14.9 mL/min/1.73 m2 (16.6%) from baseline to 4 years (P < 0.0001). In conclusion, in HBeAg-positive and HBeAg-negative CHB patients without resistance after 2 years, two additional years of telbivudine treatment continued to provide effective viral suppression with a favourable safety profile. Moreover, telbivudine achieved 53% of HBeAg seroconversion in HBeAg-positive patients. PMID:23490388

  18. Smos Instrument Performance and Calibration after 4 Years and 6 Months in Orbit

    NASA Astrophysics Data System (ADS)

    Martin-Neira, Manuel; Corbella, Ignasi; Torres, Francesc; Kainulainen, Juha; Oliva, Roger; Closa, Josep; Cabot, François; Khazaal, Ali; Anterrieu, Eric; Barbosa, Jose; Gutierrez, Antonio; Freitas, Sofia; Tenerelli, Joe; Martin-Porqueras, Fernando; Díez-García, Raul; Fauste, Jorge; Delwart, Steven; Crapolicchio, Raffaele; Suess, Martin

    2014-05-01

    By April 2014, ESA's Soil Moisture and Ocean Salinity (SMOS) mission will have been in orbit for 4 years and a half, and the second reprocessing of the whole mission data set will have taken place with a fully polarimetric Level-1 processor, for the first time. The assessment of the mission performances based on this new processor will then be possible. In particular the metrics of the spatial ripple and the temporal variations (including orbital, seasonal and long term drifts) will be evaluated and compared against the corresponding values achieved with the current version of the Level-1 processor. This will allow quantifying the improvement of the brightness temperature observations of SMOS since its launch. It is expected that the reprocessed data will no longer exhibit any negative trend in the brightness temperatures at low incidence angles, and that the seasonal and yearly drifts will have been substantially reduced. Other improvements, although not so significant, are also expected, such as a small reduction in the spatial ripple and in the orbital variations. All these benefits come thanks to the readiness of the first fully-polarimetric version of the Level-1 processor, which has been possible, to a great extent, after the correction of some inconsistencies in the use of the cross-polar antenna patterns, the positive cumulative effect of many small improvements in the calibration, a major modification of the image reconstruction processor using the complete polarimetric formulation and the utilization of the available redundancy on-board that allows the selection of the best Noise Injection Radiometer. Major areas that require further work include the correction and handling of the Sun effects, the further reduction of the spatial ripple and temporal variations, some correction of the residual land-sea contamination and an improved Radio-Frequency Interference data flagging. The Sun correction will be attempted through increasingly more complex

  19. Results.

    ERIC Educational Resources Information Center

    Zemsky, Robert; Shaman, Susan; Shapiro, Daniel B.

    2001-01-01

    Describes the Collegiate Results Instrument (CRI), which measures a range of collegiate outcomes for alumni 6 years after graduation. The CRI was designed to target alumni from institutions across market segments and assess their values, abilities, work skills, occupations, and pursuit of lifelong learning. (EV)

  20. Brown midrib corn silage fed during the peripartal period increased intake and resulted in a persistent increase in milk solids yield of Holstein cows.

    PubMed

    Stone, W C; Chase, L E; Overton, T R; Nestor, K E

    2012-11-01

    the BMRCS treatment were likely because of a reduction in fill, whereas the increased intakes in the postpartum period in cows fed the BMRCS were either because of the higher intakes during the prepartum period or because of a reduction in fill limitations in the postpartum period. The carryover response in wk 4 to 15 may have resulted from cows that received BMRCS during the transition period being in a more positive nutrient balance than cows fed CCS. The results of this study indicate the importance that digestible NDF can have in transition diets and the long-term production responses that can occur when intake is increased in the transition period. PMID:22959939

  1. A 4-year sediment trap record of alkenones from the filamentous upwelling region off Cape Blanc, NW Africa and a comparison with distributions in underlying sediments

    NASA Astrophysics Data System (ADS)

    Müller, Peter J.; Fischer, Gerhard

    2001-08-01

    We analysed long-chain alkenones in sinking particles and surface sediments from the filamentous upwelling region off Cape Blanc, NW Africa, to evaluate the transfer of surface water signals into the geological record. Our study is based on time-series sediment trap records from 730 m (1990-1991) to 2195-3562 m depth (1988-1991). Alkenone fluxes showed considerable interannual variations and no consistent seasonality. The average flux of C 37 and C 38 alkenones to the deep traps was 1.9 μg m -2 d -1 from March 1988 to October 1990 and sevenfold higher in the subsequent year. Alkenone fluxes to the shallower traps were on average twice as high and showed similar temporal variations. The alkenone unsaturation indices UK' 37, UK38Me and UK38Et closely mirrored the seasonal variations in sea-surface temperature (weekly Reynolds SST). Time lags of 10-48 days between the SST and unsaturation maxima suggest particle sinking rates of about 80 and 280 m d -1 for the periods of low and high alkenone fluxes, respectively. The average flux-weighted UK' 37 temperature for the 4-year time series of the deeper traps was 22.1°C, in perfect agreement with the mean weekly SST for the same period. This and the comparison with seasonal temperature variations in the upper 100 m of the water column suggests that UK' 37 records principally the yearly average of the mixed-layer temperature in this region. A comparison between the average annual alkenone fluxes to the lower traps (2400 μg m -2 yr -1) and into the underlying sediments (4 μg m -2 yr -1) suggests that only about 0.2% of the alkenones reaching the deep ocean became preserved in the sediments. The flux-weighted alkenone concentrations also decreased considerably, from 2466 μg gC -1 in the water column to 62 μg gC -1 in the surface sediments. Such a low degree of alkenone preservation is typical for slowly accumulating oxygenated sediments. Despite these dramatic diagenetic alkenone losses, the UK' 37 ratio was not

  2. Long-Term, Open-Label Safety and Efficacy of Atomoxetine in Adults with ADHD: Final Report of a 4-Year Study

    ERIC Educational Resources Information Center

    Adler, Lenard A.; Spencer, Thomas J.; Williams, David W.; Moore, Rodney J.; Michelson, David

    2008-01-01

    Objective: Previously, data from 97 weeks of open-label atomoxetine treatment of adults with attention-deficit/hyperactivity disorder (ADHD) were reported. This final report of that study presents results from over 4 years of treatment. Method: Results were derived from the study of 384 patients (125 patients remaining in the open-label trial…

  3. Undergraduate public health at 4-year institutions: it's here to stay.

    PubMed

    Riegelman, Richard K; Albertine, Susan

    2011-02-01

    Undergraduate public health education at 4-year institutions, those with and without graduate public health education, has grown rapidly during the first decade of the 21st century since the IOM recommended that "all undergraduates have access to education in public health." Much of this growth has been guided by the Educated Citizen and Public Health initiative, a collaboration of arts and sciences and public health educators that encourages introductory course work in public health, epidemiology, and global health plus undergraduate minors and majors in public health. The Educated Citizen and Public Health model, as opposed to existing professional models, envisions core public health education based on the Association of American Colleges and Universities' Liberal Education and America's Promise essential learning outcomes that encourage experiential learning, evidence-based thinking, a global and community focus, plus integration and synthesis. Public health education in this model provides solid generalist grounding for graduate education in public health as well as a range of graduate disciplines from the health professions to international affairs and from law to business. In addition, it helps ensure a broad range of college graduates who understand and support public health approaches. The Healthy People 2020 objective to increase the proportion of 4-year colleges and universities that offer minor or major in public health should help propel additional growth, especially in 4-year colleges without graduate public health education. Integrative curricula designed as part of the reform of undergraduate education provide opportunities to make evidence-based public health approaches available to a large number of undergraduates. PMID:21238873

  4. [A continuous 4-year evaluation of medical informatics education in a graduate school of health sciences using a questionnaire survey].

    PubMed

    Monzen, Satoru; Matsutani, Hideya; Kashiwakura, Ikuo

    2013-01-01

    The purpose of this study was to identify the level of awareness among undergraduate students regarding medical informatics and to ascertain whether educational training has progressed with time in the Department of Health Sciences at Hirosaki University, Japan, which is a co-medical staff training institution that conducts a 4-year university course in medical informatics. The university accepts students who have completed the 3rd grade of medical licensing tests and who have attended the medical informatics lectures for 4 years (2007-2010). The ratio of first sight terminology percentage in any given fiscal year in all the 30 terminology categories varied widely from 0% to 80%, but the trend in various categories did not vary between fiscal years. The terminology of informatics under medical technology students obtained high scores of 52.5-77.3% after attending courses, which was higher compared with students from other classes. On the other hand, student nurses and occupational therapy students obtained 0-44.2%. Each class scored a high percentage of correct answers in the medical information-related terminology. Among the radiology students who attended the classes, the percentage of correct answers in categories of "digital imaging and communication in medicine" and "picture archiving and communication system" were lower than other medical terminology categories. These results reflect the gaps in educational curriculum of 1st and 2nd grades of medical licensing tests. PMID:23358336

  5. Influence of solar ultraviolet-B radiation on Antarctic terrestrial plants: results from a 4-year field study.

    PubMed

    Day, T A; Ruhland, C T; Xiong, F S

    2001-09-01

    We examined the influence of solar ultraviolet-B radiation (UV-B; 280-315 nm) on the performance of Antarctic vascular plants (Colobanthus quitensis and Deschampsia antarctica) by placing filters that either absorbed or transmitted most solar UV-B over tundra along the Antarctic Peninsula for four consecutive growing seasons. The difference in biologically effective UV-B levels between our treatments was 65%, which was similar to the enhancement in ambient UV-B levels that appeared attributable to ozone depletion during the first 2 months of the growing season (November and December) at our site (62%). In both species, exposure to UV-B reduced vegetative growth, primarily through slower leaf elongation rates that led to shorter fully expanded leaves. In C. quitensis, exposure to UV-B also led to reductions in leaf longevity, branch production, cushion diameter growth, aboveground biomass, and thickness of the non-green cushion base and litter layer. Exposure to UV-B accelerated the development of reproductive structures and increased the number of panicles (D. antarctica) and capsules (C. quitensis) that reached maturity per unit of ground surface area covered by mother plants. However, this effect was offset by a tendency for these panicles and capsules to produce fewer spikelets and seeds. Ultimately, UV-B exposure did not effect the numbers of spikelets or seeds produced per unit of ground surface area. While seeds from plants exposed to UV-B tended to be lighter, germination rates were similar between UV-B treatments. The relative reductions in leaf elongation rates in D. antarctica attributable to UV-B exposure increased from the first (23%) through the fourth (43%) growing season, and relative reductions in leaf longevity in C. quitensis tended to increase from the first (9%) through the fourth (19%) growing season, suggesting that UV-B growth responses tended to be cumulative over successive years. PMID:11693369

  6. Colonic Necrosis in a 4-Year-Old with Hyperlipidemic Acute Pancreatitis

    PubMed Central

    Patton, Tiffany J.; Sentongo, Timothy A.; Mak, Grace Z.; Kahn, Stacy A.

    2016-01-01

    Here we report the case of a 4-year-old male with severe acute pancreatitis due to hyperlipidemia, who presented with abdominal pain, metabolic abnormalities, and colonic necrosis. This colonic complication was secondary to the extension of a large peripancreatic fluid collection causing direct serosal autodigestion by pancreatic enzymes. Two weeks following the initial presentation, the peripancreatic fluid collection developed into a mature pancreatic pseudocyst, which was percutaneously drained. To our knowledge, this is the youngest documented pediatric case of colonic necrosis due to severe pancreatitis and the first descriptive pediatric case of a colonic complication due to hyperlipidemia-induced acute pancreatitis. PMID:26925282

  7. Crown fracture of the mandibular second primary molars in a 4-year-old child

    PubMed Central

    Deshpande, Anshula; Patel, Jalark; Sujan, Sunanda Gul; Mallikarjuna, Rachappa

    2013-01-01

    Dental traumas are highly prevalent lesions in primary teeth, but crown root fractures are rare. Mostly anterior tooth segment is more commonly involved. Posterior crown root fractures are very rare. A 4-year-old girl reported to our paediatric dentistry department with a 10-day history of severe pain and discomfort in both right and left posterior teeth region. The child was suffering from severe and continuous pain and was unable to chew food. After an examination a fracture was noticed in intraoral periapical radiograph and treatment plan was decided to preserve the affected teeth. PMID:23780765

  8. Adoptive and Nonadoptive Mother–Child Behavioral Interaction: A Comparative Study at 4 Years of Age

    PubMed Central

    Suwalsky, Joan T. D.; Padilla, Christina M.; Yuen, Cynthia X.; Horn, E. Parham; Bradley, Alexandra L.; Putnick, Diane L.; Bornstein, Marc H.

    2016-01-01

    Comparable samples of low-risk adopted and nonadopted children and mothers were observed during 3 tasks at age 4 years. Quality of mother-child interactions, child level of functioning in 4 domains, and maternal parenting satisfaction and social support were assessed. Adopted children were as competent as nonadopted children on measures of developmental functioning. Both groups of mothers expressed high satisfaction and support as parents. However, ratings of child, maternal, and dyadic behavior when interacting were all lower for adoptive dyads than for nonadoptive dyads, and adoptive dyads with boys accounted for the maternal and dyadic group differences. PMID:27134518

  9. Preservation of the lung after 4-year compression by fibrous tumors of pleura.

    PubMed

    Ishibashi, Hironori; Takahashi, Ken; Kumazawa, Sachiko; Okubo, Kenichi

    2016-09-01

    Solitary fibrous tumor of the pleura is a neoplasm arising from mesenchymal tissue, which may cause dyspnea and cough. Computed tomography in a 72-year-old woman, who had been diagnosed with a 3-cm mass in the left upper lung 24 years previously, identified 15- and 10-cm tumors, with complete collapse of the lingula and lower lobe. The tumors were successfully excised with partial lung resection, and the collapsed lung was preserved. There was no recurrence or atelectasis at 4 years postoperatively. PMID:27357112

  10. [Awake Nasotracheal Intubation for a 4-Year-old Boy with an Oral Penetrating Toothbrush Injury].

    PubMed

    Kobayashi, Naoya; Ando, Kokichi; Saito, Kazutomo; Toyama, Hiroaki; Fudeta, Hiroto; Yamauchi, Masanori

    2015-09-01

    We report a case of an oral penetrating injury caused by a toothbrush in a 4-year-old 17-kg boy. The toothbrush was lodged in the right cervical region through the oral cavity, and emergency surgery for removal was planned under general anesthesia. Although mask ventilation was not possible because of the protruding toothbrush handle, awake nasotracheal intubation was successfully performed with a fiber-scope and intravenous fentanyl 25 μg. We conclude that appropriate analgesics could facilitate awake intubation in pediatric patients. PMID:26466500

  11. Colonic Necrosis in a 4-Year-Old with Hyperlipidemic Acute Pancreatitis.

    PubMed

    Patton, Tiffany J; Sentongo, Timothy A; Mak, Grace Z; Kahn, Stacy A

    2016-01-01

    Here we report the case of a 4-year-old male with severe acute pancreatitis due to hyperlipidemia, who presented with abdominal pain, metabolic abnormalities, and colonic necrosis. This colonic complication was secondary to the extension of a large peripancreatic fluid collection causing direct serosal autodigestion by pancreatic enzymes. Two weeks following the initial presentation, the peripancreatic fluid collection developed into a mature pancreatic pseudocyst, which was percutaneously drained. To our knowledge, this is the youngest documented pediatric case of colonic necrosis due to severe pancreatitis and the first descriptive pediatric case of a colonic complication due to hyperlipidemia-induced acute pancreatitis. PMID:26925282

  12. SSPS-CRS first period of operation: preliminary operation results, experiences, and events. IEA Small Solar Power Systems Project SR4

    SciTech Connect

    Bucher, W.

    1984-05-01

    Some lessons learned from operating the SSPS-CRS plant for over one and a half years are presented and major results from the evaluation of plant performance data are provided. Meteorological conditions at the site during the period of operation are described, including insolation, wind, temperatures, precipitation, and a thunderstorm. The performance of the heliostat field system, receiver, sodium heat transfer system, and power conversion system is discussed, and results are given of heliostat flux measurements, receiver efficiencies and losses, sodium heat transfer system losses, heat transfer system performance and efficiency. (LEW)

  13. Cognitive performance as a predictor of functional decline among the non-disabled elderly dwelling in a Japanese community: a 4-year population-based prospective cohort study.

    PubMed

    Iwasa, Hajime; Gondo, Yasuyuki; Yoshida, Yuko; Kwon, Jinhee; Inagaki, Hiroki; Kawaai, Chieko; Masui, Yukie; Kim, Hunkyung; Yoshida, Hideyo; Suzuki, Takao

    2008-01-01

    This study longitudinally examined the relationships between the specific domains of cognitive performance and functional decline among the community elderly. The study population was 119 men and 194 women aged 70-84 at baseline, who were examined at both baseline and in a 4-year follow-up survey. Katz's Index and the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) were used for measuring the functional capacities of basic activities of daily living (BADL) and higher-level competence, respectively. For the purpose of analyses, declines in each subscale of functional capacity during the follow-up period were used as outcome variables; and specific domains of cognitive performances, including information processing speed, executive function, orientation, and episodic memory at baseline, were used as independent variables. Multiple logistic regression analyses, adjusted for the potential confounders, showed that information processing speed and orientation were associated independently and inversely with BADL decline, and that information processing speed and executive function were related independently and inversely to higher-level competence decline. These results suggested that information processing speed and orientation are reliable predictors for decline in BADL, and information processing speed and executive function are also reliable predictors for decline in higher-level competence among the community elderly. PMID:17854924

  14. Enactment of Third-Party Punishment by 4-Year-Olds

    PubMed Central

    Kenward, Ben; Östh, Therese

    2012-01-01

    When prompted, preschoolers advocate punishment for moral transgressions against third parties, but little is known about whether and how they might act out such punishment. In this study, adult demonstrators enacted doll stories in which a perpetrator child doll made an unprovoked attack on a victim child doll, after which an adult doll punished either the perpetrator (consistent punishment) or victim (inconsistent punishment). When asked to help retell the story, given free choice of their own preferred actions for the adult doll, 4-year-olds (N = 32) were influenced by the demonstrated choice of target when selecting a target for punishment or admonishment. This influence was weak following inconsistent punishment, however, because the participants tended to change the story by punishing or admonishing the perpetrator when the demonstrator had punished the victim. Four-year-olds’ tendency to select a moral rule violator as a target for punishment is therefore stronger than their tendency to copy the specific actions of adults, which itself is known to be very strong. The evidence suggests that 4-year-olds’ enactment of punishment is at least partially based on a belief that antisocial actions deserve to be punished. PMID:23162486

  15. Problem Periods

    MedlinePlus

    ... gov/ Home Body Getting your period Problem periods Problem periods It’s common to have cramps or feel ... doctor Some common period problems Signs of period problems top One way to know if you may ...

  16. Predictions of mortality from pleural mesothelioma in Italy: a model based on asbestos consumption figures supports results from age-period-cohort models.

    PubMed

    Marinaccio, Alessandro; Montanaro, Fabio; Mastrantonio, Marina; Uccelli, Raffaella; Altavista, Pierluigi; Nesti, Massimo; Costantini, Adele Seniori; Gorini, Giuseppe

    2005-05-20

    Italy was the second main asbestos producer in Europe, after the Soviet Union, until the end of the 1980s, and raw asbestos was imported on a large scale until 1992. The Italian pattern of asbestos consumption lags on average about 10 years behind the United States, Australia, the United Kingdom and the Nordic countries. Measures to reduce exposure were introduced in the mid-1970s in some workplaces. In 1986, limitations were imposed on the use of crocidolite and in 1992 asbestos was definitively banned. We have used primary pleural cancer mortality figures (1970-1999) to predict mortality from mesothelioma among Italian men in the next 30 years by age-cohort-period models and by a model based on asbestos consumption figures. The pleural cancer/mesothelioma ratio and mesothelioma misdiagnosis in the past were taken into account in the analysis. Estimated risks of birth cohorts born after 1945 decrease less quickly in Italy than in other Western countries. The findings predict a peak with about 800 mesothelioma annual deaths in the period 2012-2024. Results estimated using age-period-cohort models were similar to those obtained from the asbestos consumption model. PMID:15645436

  17. Knowing Minds, Controlling Actions: The Developmental Relations between Theory of Mind and Executive Function from 2 to 4 Years of Age

    ERIC Educational Resources Information Center

    Muller, Ulrich; Liebermann-Finestone, Dana P.; Carpendale, Jeremy I. M.; Hammond, Stuart I.; Bibok, Maximilian B.

    2012-01-01

    This longitudinal study examined the concurrent and predictive relations between executive function (EF) and theory of mind (ToM) in 82 preschoolers who were assessed when they were 2, 3, and 4 years old. The results showed that the concurrent relation between EF and ToM, after controlling for age, verbal ability, and sex, was significant at 3 and…

  18. Effects of prenatal exposure to perfluoroalkyl acids on prevalence ofallergic diseases among 4-year-old children.

    PubMed

    Goudarzi, Houman; Miyashita, Chihiro; Okada, Emiko; Kashino, Ikuko; Kobayashi, Sumitaka; Chen, Chi-Jen; Ito, Sachiko; Araki, Atsuko; Matsuura, Hideyuki; Ito, Yoichi M; Kishi, Reiko

    2016-09-01

    Perfluoroalkyl acids (PFAAs) are ubiquitous chemicals extremely resistant and widespread throughout the environment, frequently being detected in human blood samples. Animal studies have revealed that exposure to PFAAs results in immunotoxicity. However, the association between PFAAs, especially long-chain PFAAs, and allergies in humans is not well established. We examined whether prenatal exposure to PFAAs is associated with allergic diseases among 4-year-old children in a large-scale prospective birth cohort in Hokkaido, Japan. In total, 1558 mother-child pairs were included in this study and prenatal levels of eleven PFAAs were measured in maternal plasma samples obtained between 28 and 32weeks of pregnancy by using ultra-performance liquid chromatography-tandem mass spectrometry. Participant demographic and characteristic information were obtained from self-administered pre- and postnatal questionnaires and medical birth records. Infant allergies were assessed using the Japanese version of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three questionnaire, which was administered 4years post-delivery. Symptoms included eczema, wheezing and rhinoconjunctivitis with a prevalence of 19.0%, 18.7%, and 5.4%, respectively. Associations of PFAA quartiles with allergic outcomes were examined using logistic models. Adjusted odds ratios (ORs) in the 4th quartile vs. 1st quartile (Q4 vs. Q1) for total allergic diseases (including at least one allergic outcome) significantly decreased for perfluorododecanoic acid (PFDoDa) (Q4 vs. Q1 OR: 0.621; 95% confidence interval (CI): 0.454, 0.847) and perfluorotridecanoic acid (PFTrDA) (Q4 vs. Q1 OR: 0.712; 95% CI: 0.524, 0.966) in all children. We obtained similar results when examining the association between PFAAs and eczema. The adjusted OR (Q4 vs. Q1) for wheezing in relation to higher maternal PFHxS levels was 0.728 (95% CI: 0.497, 1.06) in all children. In conclusion, prenatal exposure to long

  19. Is anastomotic urethroplasty is really superior than BMG augmented dorsal onlay urethroplasty in terms of outcomes and patient satisfaction: Our 4-year experience

    PubMed Central

    Choudhary, Anil Kumar; Jha, Nawal K.

    2015-01-01

    Introduction We analyzed the outcomes of augmented buccal mucosa graft (BMG) dorsal onlay urethroplasty and anastomotic urethroplasty in the management of urethral stricture. Methods: Patients having a stricture length more than 2 cm were treated by augmented BMG dorsal onlay urethroplasty; patients with a stricture length less than 2 cm were managed by excision and end-to-end anastomotic urethroplasty. The postoperative retrograde urethrogram, micturating cystourethrogram, and uroflowmetry were compared to preoperative values. The postoperative subjective symptoms and complications were recorded and analyzed. Results: In total, 90 patients were included in this study. Forty-five patients had an average stricture length of 5.9 cm; they underwent BMG augmented dorsal onlay urethroplasty. Of these, 7 (15.55%) patients came with recurrence, while 38 (84.44%) were asymptomatic, in the average follow-up period of 32.8 months. The next 45 patients underwent excision of the stricture and end-to-end anastomosis. Of these, 6 (13.33%) failed on therapy and the remaining 39 (86.66%) were asymptomatic during the average follow-up period of 28.4 months. Conclusion: The technique of BMG dorsal onlay is easy to do, it is very reliable, has high success rate, less postoperative complications and better patient satisfaction compared to anastomotic urethroplasty. Our study has its limitations. Recurrent cases of urethroplasty and hypospadias were excluded from this study. Recurrent stricture cases were eliminated to overcome bias. Cases of hypospadias are still best treated by axial or random penile skin flap as BMG augmentation cannot create a long urethral tube. Based on our 4-year experience, we recommend BMG augmented urethroplasty long and short segment stricture of the urethra. PMID:25624962

  20. Diabetic ketoacidosis in a 9 month old child and the journey to 4 years.

    PubMed

    Chapp-Jumbo, Assumpta Udechi; Ijeoma, Stella

    2014-01-01

    We report a case of diabetes mellitus in a 9-month-old male, a product of a non-consanguinous marriage with no family history of diabetes mellitus. He presented initially with ketoacidosis in our emergency room and recovered from coma after 48 hours but was discharged after 14 days. He is now 4 years old and doing well and caregivers are coping even with the challenges of caring for a very young diabetic child. This article will help to build up the data bank for diabetes in infancy and childhood in our environment as well as highlight the challenges faced by both caregivers and physicians in the management of very young diabetics irrespective of socioeconomic status. PMID:25567469

  1. Predicting Reading and Spelling Disorders: A 4-Year Prospective Cohort Study

    PubMed Central

    Bigozzi, Lucia; Tarchi, Christian; Caudek, Corrado; Pinto, Giuliana

    2016-01-01

    In this 4-year prospective cohort study, children with a reading and spelling disorder, children with a spelling impairment, and children without a reading and/or spelling disorder (control group) in a transparent orthography were identified in third grade, and their emergent literacy performances in kindergarten compared retrospectively. Six hundred and forty-two Italian children participated. This cohort was followed from the last year of kindergarten to third grade. In kindergarten, the children were assessed in phonological awareness, conceptual knowledge of writing systems and textual competence. In third grade, 18 children with a reading and spelling impairment and 13 children with a spelling impairment were identified. Overall, conceptual knowledge of the writing system was the only statistically significant predictor of the clinical samples. No differences were found between the two clinical samples. PMID:27014145

  2. Acute phenytoin intoxication in a 4-year-old mimicking viral meningoencephalitis

    PubMed Central

    Shukla, Amlin; Sankar, Jhuma; Verma, Ankit; Dubey, Nandkishore

    2013-01-01

    We report here the case of a 4-year-old female preschooler who presented to the emergency department with generalised tonic-clonic convulsions and history of vomiting, irritability and dysarthria of short duration. On examination she was found to be responsive only to painful stimulus, had terminal neck stiffness and bilateral extensor plantars. In view of her clinical presentation, an initial diagnosis of viral meningoencephalitis was made in the emergency room and the child treated accordingly. On subsequent transfer to the intensive care unit (ICU), the parents revealed additional history of an elder sibling taking phenytoin for seizures. Therefore, a suspicion of acute phenytoin toxicity was made and phenytoin levels sent for confirmation. Her serum phenytoin level was 80 μgm/mL (normal: 10–20). The child was managed conservatively and discharged after 5 days of hospitalisation. We chose to report this case to highlight the unusual presentation of this rare intoxication. PMID:23814089

  3. From community college to 4-year institutions: Latinas' successful completion of STEM baccalaureate degrees

    NASA Astrophysics Data System (ADS)

    Zamudio, Rocio

    The purpose of this qualitative study was to explore the narrative of Latina graduates who successfully navigated through community college and 4-year institutions in the STEM fields. Rather than focus on what these students lack as much of the current research does, the study explored what assets these students bring that supports their success in STEM fields. Utilizing an ethnographic interview approach, participants who attained STEM baccalaureates in California were interviewed. Qualitative findings revealed various experiences, attitudes, and cultural influences that led to successful completion of a STEM degree. First, the study found that successful community college Latina STEM graduates exhibit grit, are resilient, determined, and have positive attitudes about their underrepresentation in STEM. Second, participants sought after peer, faculty, and staff relationships that helped them be successful. Lastly, participants had the support of their families and reported a high level of connectedness to their culture. Implications, recommendations for practice, and directions for future research are discussed.

  4. A Review and Report of Peripheral Giant Cell Granuloma in a 4-Year-Old Child

    PubMed Central

    Nekouei, Afsaneh; Eshghi, Alireza; Jafarnejadi, Parisa

    2016-01-01

    Peripheral giant cell granuloma is a common benign and reactive gingival epulis in oral cavity. It is often difficult to make a clinical diagnosis; thereby definitive diagnosis depends on histopathologic features. We report a case of a 4-year-old Caucasian boy presenting with a five-month history a 20 × 15 × 12 mm pedunculated, lobular soft tissue mass of the left anterior maxilla gingiva which was misdiagnosed and maltreated before his referral. An excisional biopsy of the lesion followed by histopathologic examination of the biopsy specimen revealed distinctive features of peripheral giant cell granuloma. Early detection and excision of this hyperplastic nodule especially in children are important to minimize potential dentoalveolar complications. PMID:27403351

  5. [Noma in a 4 year-old girl: a case report from Chad].

    PubMed

    Cocquempot, K; Javaudin, O; Lerasle, P; Aigle, L

    2014-01-01

    This case report describes a 4-year-old girl in Chad with noma, also called cancrum oris. This acute gangrenous stomatitis has a combined morbidity-mortality rate that can reach 70%. It occurs worldwide but is most common in sub-Saharan Africa in children aged 2 to 16 years. Its pathogenesis is uncertain, but several bacteria including Fusobacterium necrophorum, Prevotella intermedia and Pseudomonas aeruginosa may be responsible for the development of noma, which develops over the oral lesions these bacteria cause. Poverty is its most important risk factor. Due to its rapid course and high lethality, it requires emergency treatment with antibiotics, daily dressing of the lesion, and nutritional rehabilitation. Surgical removal of the remaining necrotic tissue can be followed by reconstructive procedures. Physical and speech therapy should be initiated to prevent functional complications. PMID:24736219

  6. College for All? Is There Too Much Emphasis on Getting a 4-Year College Degree? Research Synthesis.

    ERIC Educational Resources Information Center

    Boesel, David; Fredland, Eric

    Over the years, larger and larger portions of high school graduates have enrolled in 4-year colleges. Although many people view college as essential to success in the labor market, the movement toward 4-year colleges also has its critics. These critics contend that the public has come to believe that almost all high school graduates should go to…

  7. Long-Term Exercise in Older Adults: 4-Year Outcomes of Music-Based Multitask Training

    PubMed Central

    Herrmann, François R.; Fielding, Roger A.; Reid, Kieran F.; Rizzoli, René; Trombetti, Andrea

    2016-01-01

    Prospective controlled evidence supporting the efficacy of long-term exercise to prevent physical decline and reduce falls in old age is lacking. The present study aimed to assess the effects of long-term music-based multitask exercise (i.e., Jaques-Dalcroze eurhythmics) on physical function and fall risk in older adults. A 3-year follow-up extension of a 1-year randomized controlled trial (NCT01107288) was conducted in Geneva (Switzerland), in which 134 community-dwellers aged ≥65 years at increased risk of falls received a 6-month music-based multitask exercise program. Four years following original trial enrolment, 52 subjects (baseline mean ± SD age, 75 ± 8 years) who (i) have maintained exercise program participation through the 4-year follow-up visit (“long-term intervention group”, n = 23) or (ii) have discontinued participation following original trial completion (“control group”, n = 29) were studied. They were reassessed in a blind fashion, using the same procedures as at baseline. At 4 years, linear mixed-effects models showed significant gait (gait speed, P = 0.006) and balance (one-legged stance time, P = 0.015) improvements in the long-term intervention group, compared with the control group. Also, long-term intervention subjects did better on Timed Up & Go, Five-Times-Sit-to-Stand and handgrip strength tests, than controls (P < 0.05, for all comparisons). Furthermore, the exercise program reduced the risk of falling (relative risk, 0.69; 95 % confidence interval, 0.5–0.9; P = 0.008). These findings suggest that long-term maintenance of a music-based multitask exercise program is a promising strategy to prevent age-related physical decline in older adults. They also highlight the efficacy of sustained long-term adherence to exercise for falls prevention. PMID:25148876

  8. Long-term exercise in older adults: 4-year outcomes of music-based multitask training.

    PubMed

    Hars, Mélany; Herrmann, François R; Fielding, Roger A; Reid, Kieran F; Rizzoli, René; Trombetti, Andrea

    2014-11-01

    Prospective controlled evidence supporting the efficacy of long-term exercise to prevent physical decline and reduce falls in old age is lacking. The present study aimed to assess the effects of long-term music-based multitask exercise (i.e., Jaques-Dalcroze eurhythmics) on physical function and fall risk in older adults. A 3-year follow-up extension of a 1-year randomized controlled trial (NCT01107288) was conducted in Geneva (Switzerland), in which 134 community-dwellers aged ≥65 years at increased risk of falls received a 6-month music-based multitask exercise program. Four years following original trial enrolment, 52 subjects (baseline mean ± SD age, 75 ± 8 years) who (i) have maintained exercise program participation through the 4-year follow-up visit ("long-term intervention group", n = 23) or (ii) have discontinued participation following original trial completion ("control group", n = 29) were studied. They were reassessed in a blind fashion, using the same procedures as at baseline. At 4 years, linear mixed-effects models showed significant gait (gait speed, P = 0.006) and balance (one-legged stance time, P = 0.015) improvements in the long-term intervention group, compared with the control group. Also, long-term intervention subjects did better on Timed Up & Go, Five-Times-Sit-to-Stand and handgrip strength tests, than controls (P < 0.05, for all comparisons). Furthermore, the exercise program reduced the risk of falling (relative risk, 0.69; 95% confidence interval, 0.5-0.9; P = 0.008). These findings suggest that long-term maintenance of a music-based multitask exercise program is a promising strategy to prevent age-related physical decline in older adults. They also highlight the efficacy of sustained long-term adherence to exercise for falls prevention. PMID:25148876

  9. Changes in bread consumption and 4-year changes in adiposity in Spanish subjects at high cardiovascular risk.

    PubMed

    Bautista-Castaño, I; Sánchez-Villegas, A; Estruch, R; Martínez-González, M A; Corella, D; Salas-Salvadó, J; Covas, M I; Schroder, H; Alvarez-Pérez, J; Quilez, J; Lamuela-Raventós, R M; Ros, E; Arós, F; Fiol, M; Lapetra, J; Muñoz, M A; Gómez-Gracia, E; Tur, J; Pintó, X; Ruiz-Gutierrez, V; Portillo-Baquedano, M P; Serra-Majem, L

    2013-07-28

    The effects of bread consumption change over time on anthropometric measures have been scarcely studied. We analysed 2213 participants at high risk for CVD from the PREvención con DIeta MEDiterránea (PREDIMED) trial to assess the association between changes in the consumption of bread and weight and waist circumference gain over time. Dietary habits were assessed with validated FFQ at baseline and repeatedly every year during 4 years of follow-up. Using multivariate models to adjust for covariates, long-term weight and waist circumference changes according to quartiles of change in energy-adjusted white and whole-grain bread consumption were calculated. The present results showed that over 4 years, participants in the highest quartile of change in white bread intake gained 0·76 kg more than those in the lowest quartile (P for trend = 0·003) and 1·28 cm more than those in the lowest quartile (P for trend < 0·001). No significant dose-response relationships were observed for change in whole-bread consumption and anthropometric measures. Gaining weight (>2 kg) and gaining waist circumference (>2 cm) during follow-up was not associated with increase in bread consumption, but participants in the highest quartile of changes in white bread intake had a reduction of 33 % in the odds of losing weight (>2 kg) and a reduction of 36 % in the odds of losing waist circumference (>2 cm). The present results suggest that reducing white bread, but not whole-grain bread consumption, within a Mediterranean-style food pattern setting is associated with lower gains in weight and abdominal fat. PMID:23199451

  10. METHODS AND RESULTS OF RECONSTRUCTION OF NOBLE GAS RELEASES FROM THE STACKS OF THE MAYAK PA GRAPHITE REACTORS OVER THE WHOLE PERIOD OF THEIR OPERATION

    SciTech Connect

    Glagolenko, Y. V.; Drozhko, Evgeniy G.; Mokrov, Y.; Pyatin, N. P.; Rovny, Sergey I.; Anspaugh, L. R.; Napier, Bruce A.

    2008-06-01

    Brief analysis of design features and operational modes of Mayak PA industrial graphite-uranium reactors (PUGRs) is given. The above mentioned Mayak PA PUGRs determined the rates of releases of radioactive noble gases (RNG) from activation (41Ar) and fission (isotopes of Krypton and Xenon) through the vent stack of the reactor. Information is given on methods and results of experimental determination of RNG atmospheric releases for the period starting from 1965 till PUGRs decommissioning in 1987-1990. A calculation method for reconstruction of radioactive noble gas releases is proposed and justified. The results of reconstruction are given. It is shown that maximum rates of RNG releases from PUGRs high stacks were observed in the 1950s, when ordinary atmospheric air was used as a cover gas for the reactor graphite stacks and gas purification systems (flow-type gas holders) had not been installed yet.

  11. In-Hospital and 4-Year Clinical Outcomes Following Transcatheter Versus Surgical Closure for Secundum Atrial Septal Defect in Adults

    PubMed Central

    Chen, Tien-Hsing; Hsiao, Yuan-Chuan; Cheng, Chia-Chi; Mao, Chun-Tai; Chen, Dong-Yi; Tsai, Ming-Lung; Yang, Teng-Yao; Lin, Yu-Sheng

    2015-01-01

    Abstract Atrial septal defect (ASD) closure is major therapy for patients with secundum ASD. Although surgical closure (SC) and transcatheter closure (TC) are usually performed in such patients, data on the long-term outcomes comparing TC and SC in adults are limited. Data on the participants of this cohort study were retrieved from Taiwan's National Health Insurance Research Database from 2004 to 2011. Secundum ASD patients > 18 years of age who underwent TC or SC were initially enrolled, and those with associated comorbidities were excluded. After propensity score matching, the clinical outcomes between the TC and SC groups were analyzed. There were 595 patients recruited in the TC group and 308 patients in the SC group. The SC group had a higher incidence of systemic thromboembolism (P < 0.001), ischemic stroke (P = 0.002), and all-cause mortality (P = 0.013) when compared with those of the TC group at the index hospitalization, and similar phenomena could also be seen in a around 4-year follow-up period after the procedures (systemic thromboembolism (P < 0.001, HR = 11.48, 95% CI: 3.29–40.05), ischemic stroke (P = 0.005, HR = 9.28, 95% CI: 1.94–44.39), and all-cause mortality (P = 0.035, HR = 2.28, 95% CI: 1.06–4.89). In addition, atrial fibrillation (P = 0.005) and atrial flutter (P = 0.049) more frequently developed in the SC group than in the TC group at the index hospitalization. The adult secundum ASD patients had lower incidence rates of systemic thromboembolism, ischemic stroke, and all-cause mortality after TC than those after SC in the 4-year follow-up after procedures. Transcatheter ASD closure should therefore be given priority PMID:26402807

  12. Results of Experimental and Theoretical Studies of the Atmospheric Turbulence, Internal Gravity Waves and Sporadic-E Layers by Resonant Scattering of Radio Waves on Artificial Periodic Irregularities

    NASA Astrophysics Data System (ADS)

    Bakhmetieva, Nataliya V.; Grigoriev; Tolmacheva, Ariadna V.

    Artificial periodic irregularities (API) formed by the powerful standing radio waves in the ionospheric plasma give the good chance for the lower ionosphere comprehensive studies. In this paper we present some applications of the API technique for experimental studies of sporadic E-layers (E _{s}), internal gravity waves and turbulent events in the lower ionosphere. API are formed in the field of the standing radio wave produced by interference of the incident wave and reflected one from the ionosphere (in more details about the API technique one can see in the book Belikovich et al., Ionospheric Research by Means of Artificial Periodic Irregularities - Katlenburg-Lindau, Germany. 2002. Copernicus GmbH. ISBN 3-936586-03-9). The spatial period of the irregular structure is equal to the standing wavelength Lambda or one-half the powerful wavelength lambda/2. API diagnostics are carried out at the API relaxation or decay stage by their sounding of probing radio pulses. Based on the measurement of an amplitude and a phase of the API scattered signal their relaxation time and regular vertical plasma velocity are measured. In the E-region of the ionosphere API are formed as a result of the diffusion redistribution of the non-uniformly heated plasma. The relaxation of the periodic structure is specified by the ambipolar diffusion process. The diffusion time is tau=(K (2) D _{a}) (-1) where K=2pi/Lambda and D _{a} is the ambipolar diffusion rate. The atmospheric turbulence causes reduction of the API relaxation time in comparison the diffusion time. Determination of the turbulent velocity is based on this fact. The vertical plasma velocity is determined by measuring the phase of the scattered signal. Atmospheric waves having the periods from 5-10 minutes to 5-6 hours give the contribution to temporal variations of the velocity. Parameters and effects of atmospheric waves and the turbulence on the API relaxation process are presented. Determination of the masses of the

  13. Calibration and systematic error analysis for the COBE(1) DMR 4year sky maps

    SciTech Connect

    Kogut, A.; Banday, A.J.; Bennett, C.L.; Gorski, K.M.; Hinshaw,G.; Jackson, P.D.; Keegstra, P.; Lineweaver, C.; Smoot, G.F.; Tenorio,L.; Wright, E.L.

    1996-01-04

    The Differential Microwave Radiometers (DMR) instrument aboard the Cosmic Background Explorer (COBE) has mapped the full microwave sky to mean sensitivity 26 mu K per 7 degrees held of view. The absolute calibration is determined to 0.7 percent with drifts smaller than 0.2 percent per year. We have analyzed both the raw differential data and the pixelized sky maps for evidence of contaminating sources such as solar system foregrounds, instrumental susceptibilities, and artifacts from data recovery and processing. Most systematic effects couple only weakly to the sky maps. The largest uncertainties in the maps result from the instrument susceptibility to Earth's magnetic field, microwave emission from Earth, and upper limits to potential effects at the spacecraft spin period. Systematic effects in the maps are small compared to either the noise or the celestial signal: the 95 percent confidence upper limit for the pixel-pixel rms from all identified systematics is less than 6 mu K in the worst channel. A power spectrum analysis of the (A-B)/2 difference maps shows no evidence for additional undetected systematic effects.

  14. Exercise frequency and calcium intake predict 4-year bone changes in postmenopausal women.

    PubMed

    Cussler, Ellen C; Going, Scott B; Houtkooper, Linda B; Stanford, Vanessa A; Blew, Robert M; Flint-Wagner, Hilary G; Metcalfe, Lauve L; Choi, Ji-Eun; Lohman, Timothy G

    2005-12-01

    The aim of this study was to examine the association of exercise frequency and calcium intake (CI) with change in regional and total bone mineral density (BMD) in a group of postmenopausal women completing 4 years of progressive strength training. One hundred sixty-seven calcium-supplemented (800 mg/day) sedentary women (56.1+/-4.5 years) randomized to a progressive strength training exercise program or to control were followed for 4 years. Fifty-four percent of the women were using hormone therapy (HT) at baseline. At 1 year, controls were permitted to begin the exercise program (crossovers). The final sample included 23 controls, 55 crossovers, and 89 randomized exercisers. Exercisers were instructed to complete two sets of six to eight repetitions of exercises at 70-80% of one repetition maximum, three times weekly. BMD was measured at baseline and thereafter annually using dual-energy X-ray absorptiometry. Four-year percentage exercise frequency (ExFreq) averaged 26.8%+/-20.1% for crossovers (including the first year at 0%), and 50.4%+/-26.7% for exercisers. Four-year total CI averaged 1,635+/-367 mg/day and supplemental calcium intake, 711+/-174 mg/day. In adjusted multiple linear regression models, ExFreq was positively and significantly related to changes in femur trochanter (FT) and neck (FN), lumbar spine (LS), and total body (TB) BMD. Among HT users, FT BMD increased 1.5%, and FN and LS BMD, 1.2% (p<0.01) for each standard deviation (SD) of percentage ExFreq (29.5% or 0.9 days/week). HT non-users gained 1.9% and 2.3% BMD at FT and FN, respectively, (p<0.05) for every SD of CI. The significant, positive, association between BMD change and ExFreq supports the long-term usefulness of strength training exercise for the prevention of osteoporosis in postmenopausal women, especially HT users. The positive relationship of CI to change in BMD among postmenopausal women not using HT has clinical implications in light of recent evidence of an increased health risk

  15. How are the VLF quasi-periodic emissions controlled by harmonics of field line oscillations? - The results of a comparison between ground and GEOS satellites measurements

    NASA Astrophysics Data System (ADS)

    Tixier, M.; Cornilleau-Wehrlin, N.

    1986-06-01

    Data on VLF and UHF waves observed in situ for the first time by the GEOS 1 and 2 satellites close to the equatorial plane are compared with ground-based measurements. The results permit a more complete explanation of quasi-periodic (QP) modulation. The data are described, and a general ground-satellite comparison of occurrence and spectra of simultaneous emission is given. A detailed study of some selected events shows that, when the GEOS data are taken into account, it is sometimes difficult to classify QP emissions as either type I or type II. It is suggested that QPs may be due to the same mechanism involving compressional harmonics of a standing fundamental ULF wave.

  16. A 4-year shortwave and longwave radiation climatology in a dust-influenced mountain snow regime

    NASA Astrophysics Data System (ADS)

    Painter, T. H.; Barrett, A. P.; Landry, C. C.; McNeally, P. B.

    2008-12-01

    In winter 2005, we established detailed radiation infrastructure in the Senator Beck Basin Study Area (SBBSA), which lies near Red Mountain Pass in the San Juan Mountains, SW Colorado, US. The San Juan Mountains are subject to multiple dust deposition events each year, primarily in spring and summer. In the period 2004-2008, the study site received 4 to 9 deposition events a year, with mass coming primarily from the Colorado Plateau. The loading observed today is approximately 500% greater than that prior to the disturbance of fragile desert surfaces in the southwest US in the 1870s when numbers of grazing cattle and sheep began to increase dramatically. Snowmelt model sensitivity analyses indicate that snow cover duration is reduced by 25-35 days as a result of enhanced absorption of shortwave radiation by dust in the snow cover. Land surface radiative forcing as a result of early removal of snowcover is of the order 150 W/m2. In this study, we describe the shortwave and longwave climatology (winter 2005 through summer 2008) at alpine and subalpine towers in the SBBSA. At each tower, we measure incident and reflected fluxes for broadband shortwave and NIR/SWIR (from which we infer the visible fluxes), longwave irradiance and snow surface temperature (from which we infer snow longwave exitance), and noontime diffuse irradiance. A CIMEL sunphotometer (NASA AERONET site RedMountainPass) is situated near the subalpine tower to measure aerosol optical depth coordinated with the above radiation measurements. During winter and spring, the top 30 cm of the snow column was sampled at 3 cm resolution to determine the stratigraphy of dust concentration contributing to enhanced absorption.

  17. Psychotropic drug use in a cohort of workers 4 years after an industrial disaster in France.

    PubMed

    Diène, Eloi; Geoffroy-Perez, Béatrice; Cohidon, Christine; Gauvin, Stéphanie; Carton, Matthieu; Fouquet, Aurélie; Fatras, Jean-Yves; Imbernon, Ellen

    2014-08-01

    Two years after the 2001 Toulouse industrial disaster, a longitudinal study was set up to evaluate the impact of the disaster. The current substudy examines the medium-term impact (5 years) the incident had on the mental health of 3,004 participants. As part of the monitoring, data relating to the psychotropic drug use of 2,494 participants were collected from administrative databases 4 years after the disaster. Use of psychotropics was higher among women for anxiolytics (10.4% for men and 15.0% for women), hypnotics (10.5% and 17.0%), and antidepressants (7.6% and 11.2%). Exposure to the disaster, especially proximity to the exposure, was significantly associated with the use of antidepressants in men, OR = 3.22, 95% CI[1.57, 6.61]. This was also the case for other exposure factors (saw dead or injury, injured, home damage, death or injury loved one, psychological disorders, exposure toxic fumes): range of OR 1.75 to 2.52 in men, 1.48 to 1.62 in women. In conclusion, this study highlights the medium-term psychological impact of an industrial disaster on psychotropic drug use and the potential for using medical records data as a means for tracking postdisaster mental health. PMID:25158636

  18. A 4-year study of invasive and native spider populations in Maine

    USGS Publications Warehouse

    Jakob, Elizabeth M.; Porter, Adam H.; Ginsberg, Howard; Bednarski, Julie V.; Houser, Jeremy

    2011-01-01

    Invasive spiders pose potential threats to native spiders. In 2002, the European spider Linyphia triangularis (Clerck, 1757) (Araneae: Linyphiidae) was discovered in all but one county in Maine. At Acadia National Park, we conducted a 4-year study of L. triangularis and three native linyphiid species of a similar size (Frontinella communis (Hentz, 1850), Pityohyphantes subarcticus Chamberlin and Ivie, 1943, and Neriene radiata (Walckenaer, 1842)). Using line-transect surveys, we measured population densities in coastal and forest habitat. The density of L. triangularis varied across years but was always significantly higher on the coast than in the forest. In contrast, only one native species was present on the coast and at very low numbers. Coastal L. triangularis were larger and in better condition than those in the forest, and numbers and biomass of insect prey were also higher on the coast. In 2 years, we also conducted transects at a second coastal location in Maine where the invader was at low density. At that site, native densities were substantially higher than at either Acadia site. Our data are consistent with the hypothesis that L. triangularis is reducing populations of native spiders. Companion studies suggest that L. triangularis negatively impacts natives by usurping both web sites and webs.

  19. Performance of the SCUBA-2 dry dilution refrigerator: 4 years of operation at the JCMT

    NASA Astrophysics Data System (ADS)

    Bintley, Dan; Kuroda, John T.; Starman, Erik G.; Craig, Simon; Holland, Wayne S.

    2012-09-01

    Cryogen free or ‘dry’ dilution refrigerators that integrate a cryocooler such as a two stage pulse tube to replace the conventional liquid helium bath and 1K pot, have become a practical alternative for cooling astronomical detectors to mK temperatures and offer many advantages. SCUBA-2, the new submillimetre camera in operation at the JCMT, on the summit of Mauna Kea, Hawaii, was one of the first instruments to use such a fridge design. The dry dilution fridge for SCUBA-2 has now been in service for almost 4 years during commissioning at JCMT. In the most recent astronomical commissioning phase, the dilution fridge was in continuous operation for 10 months with no loss of base temperature or cooling power, cooling the SCUBA-2 detector arrays to below 100mK while maintaining a further 100Kg of enclosure, shields and SQUID amplifiers at 1K. In this paper we review some of the lessons from operating a dry dilution fridge at the JCMT and the necessary changes that have been incorporated. We present the performance of the fridge and discus its role in ensuring the success of SCUBA-2.

  20. Children's Spatial Representations: 3- and 4-Year-Olds are Affected by Irrelevant Peripheral References.

    PubMed

    Krüger, Markus; Jahn, Georg

    2015-01-01

    Children as young as 3 years can remember an object's location within an arrangement and can retrieve it from a novel viewpoint (Nardini et al., 2006). However, this ability is impaired if the arrangement is rotated to compensate for the novel viewpoint, or, if the arrangement is rotated and children stand still. There are two dominant explanations for this phenomenon: self-motion induces an automatic spatial updating process which is beneficial if children move around the arrangement, but misleading if the children's movement is matched by the arrangement and not activated if children stand still and only the arrangement is moved (see spatial updating; Simons and Wang, 1998). Another explanation concerns reference frames: spatial representations might depend on peripheral spatial relations concerning the surrounding room instead on proximal relations within the arrangement, even if these proximal relations are sufficient or more informative. To evaluate these possibilities, we rotated children (N = 120) aged between 3 and 6 years with an occluded arrangement. When the arrangement was in misalignment to the surrounding room, 3- and 4-year-olds' spatial memory was impaired and 5-year-olds' was lightly impaired suggesting that they relied on peripheral references of the surrounding room for retrieval. In contrast, 6-years-olds' spatial representation seemed robust against misalignment indicating a successful integration of spatial representations. PMID:26617537

  1. Unexpected Leiomyosarcoma 4 Years after Laparoscopic Removal of the Uterus Using Morcellation.

    PubMed

    Prins, J R; Van Oven, M W; Helder-Woolderink, J M

    2015-01-01

    Background. Laparoscopic hysterectomies are increasingly popular; a morcellation device is often used. Although there are some clear benefits, morcellation of tissue does have potential risks. Case Presentation. In this case report we present a 55-year-old woman with an abdominal tumour 4 years after a laparoscopic hysterectomy using a morcellation device. Postoperative histological analysis, compromised by morcellated tissue, showed benign myoma. Because of the benign tumour no follow-up was performed. The patient presented now with an abdominal tumour, and she was scheduled for surgical removal of the tumour. During abdominal surgery the tumour appeared malignant and biopsies were taken. Histological analysis showed leiomyosarcoma, and the patient was referred to a third care centre for further treatment. The patient recovered quickly after abdominal removal of the tumour; however, after 7 months the patient had complaints and a CT scan showed a large intra-abdominal tumour with possible lung metastasis. The patient received palliative chemotherapy and died after 10 months. Conclusion. This case shows that although unexpected after a hysterectomy, a leiomyosarcoma has to be considered in case of a suspect tumour in the lower abdomen. PMID:26491585

  2. Value of PCR in surgically treated patients with staphylococcal infective endocarditis: a 4-year retrospective study.

    PubMed

    Zaloudíková, B; Němcová, E; Pol, J; Sorm, Z; Wurmová, S; Novotná, K; Vaněrková, M; Holá, V; Růžička, F; Dušek, L; Němec, P; Freiberger, T

    2012-06-01

    The aim of the study was to establish a diagnostic value for broad-range polymerase chain reaction (br-PCR) and staphylococci-specific multiplex PCR (ssm-PCR) performed on surgical material from patients with staphylococcal infective endocarditis (IE). Data were analysed retrospectively from 60 patients with suspected staphylococcal IE and 59 controls who were surgically treated at three cardiosurgery centres over 4 years. Both PCR tests showed high agreement and could be aggregated. In patients with definite and rejected IE, the clinical sensitivity and specificity of PCR reached 89 and 95%, respectively. Tissue culture (TC) and PCR agreed with blood culture (BC) in 29% and 67% of IE cases. TC helped to determine aetiology in five BC negative cases while PCR aided in nine cases. Out of 52 patients with conclusive staphylococcal IE, 40 were diagnosed with S. aureus and 12 with coagulase-negative staphylococci. PCR was shown to be highly superior to TC in confirming preoperative diagnosis of IE. In addition to aid in culture negative patients, PCR helped to establish or refine aetiology in inconclusive cases. We suggest that simultaneous br-PCR and ssm-PCR performed on surgical material together with histopathology could significantly increase the performance of current Duke criteria. PMID:21964590

  3. Effect of Retention in First Grade on Children’s Achievement Trajectories Over 4 Years

    PubMed Central

    Wu, Wei; West, Stephen G.; Hughes, Jan N.

    2008-01-01

    The authors investigated the relatively short-term and longer term effects of grade retention in 1st grade on the growth of mathematics and reading achievement over 4 years. The authors initially identified a large multiethnic sample (n = 784) of children who were below the median in literacy at school entrance. From this sample, the authors closely matched 1 retained with 1 promoted child (n = 97 pairs) on the basis of propensity scores constructed from 72 background variables and compared growth of retained and promoted children using Rasch-modeled W scores and grade standard scores, which facilitate age-based and grade-based comparisons, respectively. When using W scores, retained children experienced a slower increase in both mathematics and reading achievement in the short term but a faster increase in reading achievement in the longer term than did the promoted children. When using grade standard scores, retained children experienced a faster increase in the short term but a faster decrease in the longer term in both mathematics and reading achievement than did promoted children. Some of the retention effects were moderated by limited English language proficiency, home-school relationship, and children’s externalizing problems. PMID:19337582

  4. Neural network treatment of 4 years long NO measurement in temperate spruce and beech forests

    NASA Astrophysics Data System (ADS)

    Dupont, R.; Butterbach-Bahl, K.; Delon, C.; Bruggemann, N.; SerçA, D.

    2008-12-01

    NO soil emissions are directly influenced by soil environmental (temperature, humidity), chemical (pH, N content, C content…) and physical (soil content, texture) variables. All these parameters exert linear or non linear influences that fluctuate in threshold and intensity between sites. Because of the lack of field experiments and to the high variability in time (diurnal and seasonal cycle) and space (regions, soil and vegetation type) of the environmental parameters influencing NO emissions, estimates of NO emissions worldwide still remain highly uncertain. In this study we developed nonlinear regressions to describe NO flux emission from soil in dependency with relevant environmental parameters for a forest site in a temperate region (Höglwald, South Germany, 1994-1997) using an Artificial Neural Network (ANN). The resulting algorithm links NO fluxes with air, surface and depth temperatures, surface WFPS (Water Field Pore Space) and humus pH. All these parameters were evaluated and selected as relevant and non redundant. Network performances are evaluated for different numbers of hidden neurons. Resulting equations linking NO fluxes from soils and variables are obtained, and show to perform well with measurements (R2 = 0.81). Average NO fluxes values of 14.6 gN ha-1 d-1 are obtained for calculated and measured fluxes. In a second part, 2002-2003 NO soil fluxes are estimated from the ANN equation obtained from 1994-1997 flux measurements performed at the same site. Overall, simulated results give a good estimation of NO fluxes, with a mean value of 15.3 gN ha d-1 close to the 21.7 gN ha d-1 measured mean for the 2002-2003 period. ANN algorithm gives also a good representation of low frequency (seasonal) variations. On the basis of our results, we suggest that ANN is a good alternative between detailed biogeochemical models and large scale models, and may be the appropriate tool for estimating NO emissions at a regional scale.

  5. Trends in drinking habits among adolescents in the Baltic countries over the period of transition: HBSC survey results, 1993–2002

    PubMed Central

    Zaborskis, Apolinaras; Sumskas, Linas; Maser, Mai; Pudule, Iveta

    2006-01-01

    Background The Baltic countries – Estonia, Latvia, and Lithuania – are considered to be an example of regional homogeneity over the period of transition. The World Health Organization cross-national study on Health Behavior in School-aged Children (HBSC) allows a comparison and time trends analysis of behavioral patterns among adolescents in this region. The aim of this study was to estimate the prevalence and trends of alcohol consumption and drunkenness among adolescents of Estonia, Latvia, and Lithuania in 1993/94, 1997/98, and 2001/02. Methods Representative samples of 5286 boys and 6485 girls aged 15 from Estonia, Latvia, and Lithuania were surveyed in 1993/94, 1997/98, and 2001/02 school-year within the framework of HBSC study. The standardized survey methods were applied. The research focused on the following outcome variables: i) frequency of drinking beer, wine, and spirits; and ii) frequency of drunkenness. The same wording of questions on the consumption of alcohol was retained in each survey. Results Beer was the most frequently used alcoholic beverage across the Baltic countries among adolescents. The rate of weekly drinking of any alcoholic beverage increased considerably during the eight years of observation, especially among Estonian and Lithuanian students. In 2001/02, 25% of boys and 12.5% of girls have reported drinking alcohol at least weekly. The rate of regular alcohol drinking was two times higher in boys, while irregular drinking was more prevalent in girls. Two or more episodes of drunkenness in the lifespan were reported by 30% of boys and 15% of girls in 1993/94 and by 52% of boys and 36% of girls in 2001/02. The use of alcoholic beverages was related to the perceived family wealth: the students from the families perceived by them as wealthy were more likely to drink weekly as compared to the students from the families perceived by them as not wealthy. Conclusion Over the period between 1993 and 2002 the prevalence of alcohol

  6. Telemonitoring in Cystic Fibrosis: A 4-year Assessment and Simulation for the Next 6 Years

    PubMed Central

    2016-01-01

    Background Innovative technologies and informatics offer a wide range of services to health districts, doctors, nurses, and patients, and is changing the traditional concept of health care. In the last few years, the availability of portable devices, their easiness to transport and use, and the capability to collect and transmit various clinical data have resulted in the fast development of telemedicine. However, despite its potential impact in improving patient conditions, and its cost effectiveness reported in literature, telemedicine is not in daily practice. Objective The aim of this study is to provide evidence of the positive impact of telemonitoring proving the sustainability of an application by sending spirometry outcomes from patients’ homes to the hospital doctors via the Internet, and from doctors to patients by an additional phone call solution. Methods We examined collected data related to clinical improvement of patients with cystic fibrosis (CF). The patients were followed-up at home using telemonitoring for a period of 10 years, with the aims to prove the sustainability of the methodology (transmissions of spirometry from the patients' home to the doctors and feedback from the doctors to the patients by phone call from the hospital). We stored and analyzed all spirometry transmissions received, and tested the possible presence to decrease the costs between the standard clinical trial (only ambulatory visits) and standard clinical trial with telemonitoring for the follow-up of patients with CF (telemedicine). This was done through an economic analysis of the costs for patients followed at home by telemonitoring. We assessed four years of observation and a simulation of total long-term costs between 2010 and 2020. Results We discovered a potential saving of €40,397.00 per patient for 10 years, actualized at €36,802.97 for the follow-up of all patients enrolled. Conclusions The results from the study suggest that telemedicine can improve the

  7. Improved safety of biologic therapy for rheumatoid arthritis over the 8-year period since implementation in Japan: long-term results from a multicenter observational cohort study.

    PubMed

    Kojima, Toshihisa; Takahashi, Nobunori; Funahashi, Koji; Asai, Shuji; Terabe, Kenya; Kaneko, Atsushi; Hirano, Yuji; Hayashi, Masatoshi; Miyake, Hiroyuki; Oguchi, Takeshi; Takagi, Hideki; Kanayama, Yasuhide; Yabe, Yuichiro; Watanabe, Tsuyoshi; Fujibayashi, Takayoshi; Shioura, Tomone; Ito, Takayasu; Yoshioka, Yutaka; Ishikawa, Hisato; Asai, Nobuyuki; Takemoto, Toki; Kojima, Masayo; Ishiguro, Naoki

    2016-04-01

    This study aimed to compare the long-term safety of biologics by initiation year of treatment in patients with rheumatoid arthritis (RA) in Japan. RA patients who started their first biologics including infliximab, etanercept, adalimumab, and tocilizumab between 2003 and 2008 were identified in the Tsurumai Biologics Communication Registry (TBCR), multicenter observational cohort, and followed for 2 years or until discontinuation of the drugs. We identified baseline predictors for adverse events (AEs) resulting in discontinuation of the first TNFI using Cox proportional hazards regression analysis. A total of 874 cases (1,340 person-years) were observed. During the observation period, 96 AEs (4.7 events/100 person-years) occurred. From 2003 to 2008, there were significant changes in disease duration, Steinbrocker stage, and disease activity in those aged ≤64 years with no increase of incidence of AEs, whereas those aged >64 years had no significant changes in these variables. In the later initiation year of treatment with biologics, the fewer AEs were observed (log-rank, p = 0.017, 2008 vs. 2003-2005). Multivariate analysis showed that the initiation year significantly impacted the incidence of AEs 6 months into the observation period [initiation at 2008 (vs. 2003-2005): OR: 0.30, 95 % CI: (0.14-0.68)] after adjusting for variables at baseline. The decrease of AEs in the later initiation year was evident in those aged >64 years. The safety of biologic therapy improved over the course of the 8 years from its implementation in Japan. PMID:26846135

  8. An experimental investigation of gapwise periodicity and unsteady aerodynamic response in an oscillating cascade. 1: Experimental and theoretical results. [turbine blades

    NASA Technical Reports Server (NTRS)

    Carta, F. O.

    1982-01-01

    Tests were conducted on a linear cascade of airfoils oscillating in pitch to measure the unsteady pressure response on selected blades along the leading edge plane of the cascade, over the chord of the center blade, and on the sidewall in the plane of the leading edge. The pressure data were reduced to Fourier coefficient form for direct comparison, and were also processed to yield integrated loads and, particularly, the aerodynamic damping coefficient. Results from the unsteady Verdon/Caspar theory for cascaded blades with nonzero thickness and camber were compared with the experimental measurements. The three primary results are: (1) from the leading edge plane blade data, the cascade was judged to be periodic in unsteady flow over the range of parameters tested; (2) the interblade phase angle was found to be the single most important parameter affecting the stability of the oscillating cascade blades; and (3) the real blade theory and the experiment were in excellent agreement for the several cases chosen for comparison.

  9. Somatosensory Evoked Field in Response to Visuotactile Stimulation in 3- to 4-Year-Old Children

    PubMed Central

    Remijn, Gerard B.; Kikuchi, Mitsuru; Shitamichi, Kiyomi; Ueno, Sanae; Yoshimura, Yuko; Nagao, Kikuko; Tsubokawa, Tsunehisa; Kojima, Haruyuki; Higashida, Haruhiro; Minabe, Yoshio

    2014-01-01

    A child-customized magnetoencephalography system was used to investigate somatosensory evoked field (SEF) in 3- to 4-year-old children. Three stimulus conditions were used in which the children received tactile-only stimulation to their left index finger or visuotactile stimulation. In the two visuotactile conditions, the children received tactile stimulation to their finger while they watched a video of tactile stimulation applied either to someone else’s finger (the finger-touch condition) or to someone else’s toe (the toe-touch condition). The latencies and source strengths of equivalent current dipoles (ECDs) over contralateral (right) somatosensory cortex were analyzed. In the preschoolers who provided valid ECDs, the stimulus conditions induced an early-latency ECD occurring between 60 and 68 ms mainly with an anterior direction. We further identified a middle-latency ECD between 97 and 104 ms, which predominantly had a posterior direction. Finally, initial evidence was found for a late-latency ECD at about 139–151 ms again more often with an anterior direction. Differences were found in the source strengths of the middle-latency ECDs among the stimulus conditions. For the paired comparisons that could be formed, ECD source strength was more pronounced in the finger-touch condition than in the tactile-only and the toe-touch conditions. Although more research is necessary to expand the data set, this suggests that visual information modulated preschool SEF. The finding that ECD source strength was higher when seen and felt touch occurred to the same body part, as compared to a different body part, might further indicate that connectivity between visual and tactile information is indexed in preschool somatosensory cortical activity, already in a somatotopic way. PMID:24715860

  10. False belief understanding and "cool" inhibitory control in 3-and 4-years-old Italian children.

    PubMed

    Bellagamba, Francesca; Addessi, Elsa; Focaroli, Valentina; Pecora, Giulia; Maggiorelli, Valentina; Pace, Beatrice; Paglieri, Fabio

    2015-01-01

    During preschool years, major developments occur in both executive function and theory of mind (ToM), and several studies have demonstrated a correlation between these processes. Research on the development of inhibitory control (IC) has distinguished between more cognitive, "cool" aspects of self-control, measured by conflict tasks, that require inhibiting an habitual response to generate an arbitrary one, and "hot," affective aspects, such as affective decision making, measured by delay tasks, that require inhibition of a prepotent response. The aim of this study was to investigate the relations between 3- and 4-year-olds' performance on a task measuring false belief understanding, the most widely used index of ToM in preschoolers, and three tasks measuring cognitive versus affective aspects of IC. To this end, we tested 101 Italian preschool children in four tasks: (a) the Unexpected Content False Belief task, (b) the Conflict task (a simplified version of the Day-Night Stroop task), (c) the Delay task, and (d) the Delay Choice task. Children's receptive vocabulary was assessed by the Peabody Picture Vocabulary test. Children's performance in the False Belief task was significantly related only to performance in the Conflict task, controlling for vocabulary and age. Importantly, children's performance in the Conflict task did not significantly correlate with their performance in the Delay task or in the Delay Choice task, suggesting that these tasks measure different components of IC. The dissociation between the Conflict and the Delay tasks may indicate that monitoring and regulating a cool process (as flexible categorization) may involve different abilities than monitoring and regulating a hot process (not touching an available and highly attractive stimulus or choosing between a smaller immediate option and a larger delayed one). Moreover, our findings support the view that "cool" aspects of IC and ToM are interrelated, extending to an Italian sample of

  11. Effects of explicit teacher-implemented phoneme awareness instruction in 4-year-olds.

    PubMed

    Tyler, Ann A; Osterhouse, Heather; Wickham, Katherine; Mcnutt, Robert; Shao, Yuanyuan

    2014-01-01

    The purpose of this study was to determine whether gains would be observed in an integrated group of 4-year-olds when phoneme awareness skills were explicitly taught by trained early childhood educators. In a quasi-experimental design with a delayed treatment approach, one classroom (N = 14) was randomly assigned to receive the instructional program in fall, while a second classroom (N = 10) served as a control and subsequently received the program in spring. Baseline assessment of speech and language skills indicated there were four participants with speech and/or language impairments. The teacher training involved an initial workshop and weekly hour-long mentoring meetings; the program was provided for 20 min a day, 4 d a week, for 10 weeks. Outcome measures of phoneme awareness and letter knowledge skills were obtained from non-standardized tasks administered pre-instruction and post-instruction, at mid-year and end-year points. When each classroom received the phoneme instruction, participants made gains in letter knowledge and phoneme level skills in comparison with group performance under regular instruction. These gains were statistically significant for phoneme blending and letter knowledge. Using an aggregate of all outcome measures, the gain for each classroom when under instruction was statistically significant as compared with when that same classroom was receiving the regular curriculum. Children with speech and/or language impairment responded more variably. Gains in the more difficult phoneme awareness skill of blending suggest the potential for marked change with an intensive, explicit classroom instruction and hold promise for SLPs collaborating with preschool teachers to provide time-efficient PA instruction. PMID:25000374

  12. Seasonal and interannual variability in algal biomass and primary production in the Mediterranean Sea, as derived from 4 years of SeaWiFS observations

    NASA Astrophysics Data System (ADS)

    Bosc, E.; Bricaud, A.; Antoine, D.

    2004-03-01

    Because the Mediterranean has been subject for several decades to increasing anthropogenic influences, monitoring algal biomass and primary production on a long-term basis is required to detect possible modifications in the biogeochemical equilibrium of the basin. This work was initiated thanks to a 4-year-long time series of SeaWiFS observations. Seasonal variations of algal biomass (estimated using a previously developed regional algorithm) and primary production were analyzed for the various regions, and compared with those estimated using the CZCS sensor (1978-1986). Also, interannual variations could be assessed for the first time. The seasonal cycles of algal biomass generally reveal a maximum in winter or spring, and a minimum in summer. Some conspicuous differences with CZCS observations (e.g., in the Northwest Basin, reduction of the deep convection zone, earlier start of the spring bloom, quasi-absence of the vernal bloom) likely result from environmental changes. Interannual variations in algal biomass are noticeable all over the basin, including in the very oligotrophic waters of the Eastern Basin. The seasonal evolution of primary production is predominantly influenced by that of algal biomass in the Western Basin (with, in particular, a spring maximum). In the Eastern Basin, the seasonal courses of PAR and biomass tend to compensate each other, and primary production varies weakly along the year. The annual values computed over the 1998-2001 period for the Western Basin (163 ± 7 gC m-2 yr-1) and the Eastern Basin (121 ± 5 gC m-2 yr-1) are lower (by 17 and 12%, respectively) than those previously derived (using the same light-photosynthesis model) from CZCS data.

  13. Measurement of the solar neutrino capture rate with gallium metal. III. Results for the 2002-2007 data-taking period

    SciTech Connect

    Abdurashitov, J. N.; Gavrin, V. N.; Gorbachev, V. V.; Gurkina, P. P.; Ibragimova, T. V.; Kalikhov, A. V.; Khairnasov, N. G.; Knodel, T. V.; Mirmov, I. N.; Shikhin, A. A.; Veretenkin, E. P.; Yants, V. E.; Zatsepin, G. T.; Bowles, T. J.; Elliott, S. R.; Teasdale, W. A.; Nico, J. S.; Cleveland, B. T.; Wilkerson, J. F.

    2009-07-15

    The Russian-American experiment SAGE began to measure the solar neutrino capture rate with a target of gallium metal in December 1989. Measurements have continued with only a few brief interruptions since that time. In this article we present the experimental improvements in SAGE since its last published data summary in December 2001. Assuming the solar neutrino production rate was constant during the period of data collection, combined analysis of 168 extractions through December 2007 gives a capture rate of solar neutrinos with energy more than 233 keV of 65.4{sub -3.0}{sup +3.1} (stat) {sub -2.8}{sup +2.6} (syst) SNU. The weighted average of the results of all three Ga solar neutrino experiments, SAGE, Gallex, and GNO, is now 66.1{+-}3.1 SNU, where statistical and systematic uncertainties have been combined in quadrature. During the recent period of data collection a new test of SAGE was made with a reactor-produced {sup 37}Ar neutrino source. The ratio of observed to calculated rates in this experiment, combined with the measured rates in the three prior {sup 51}Cr neutrino-source experiments with Ga, is 0.87{+-}0.05. A probable explanation for this low result is that the cross section for neutrino capture by the two lowest-lying excited states in {sup 71}Ge has been overestimated. If we assume these cross sections are zero, then the standard solar model including neutrino oscillations predicts a total capture rate in Ga in the range of 63 SNU to 66 SNU with an uncertainty of about 4%, in good agreement with experiment. We derive the current value of the neutrino flux produced in the Sun by the proton-proton fusion reaction to be {phi}{sub pp}{sup {center_dot}}=(6.0{+-}0.8)x10{sup 10}/(cm{sup 2} s), which agrees well with the pp flux predicted by the standard solar model. Finally, we make several tests and show that the data are consistent with the assumption that the solar neutrino production rate is constant in time.

  14. Repeated, Intermittent Social Defeat across the Entire Juvenile Period Resulted in Behavioral, Physiological, Hormonal, Immunological, and Neurochemical Alterations in Young Adult Male Golden Hamsters.

    PubMed

    Yu, Wei-Chun; Liu, Ching-Yi; Lai, Wen-Sung

    2016-01-01

    The developing brain is vulnerable to social defeat during the juvenile period. As complements of human studies, animal models of social defeat provide a straightforward approach to investigating the functional and neurobiological consequences of social defeats. Taking advantage of agonist behavior and social defeat in male golden hamster, a set of 6 experiments was conducted to investigate the consequences at multiple levels in young adulthood resulting from repeated, intermittent social defeats or "social threats" across the entire juvenile period. Male hamsters at postnatal day 28 (P28) were randomly assigned to either the social defeat, "social threat", or arena control group, and they correspondingly received a series of nine social interaction trials (i.e., either social defeat, "social threat", or arena control conditions) from P33 to P66. At the behavioral level (Experiment 1), we found that repeated social defeats (but not "social threats") significantly impacted locomotor activity in the familiar context and social interaction in the familiar/unfamiliar social contexts. At the physiological and hormonal levels (Experiments 2 and 3), repeated social defeat significantly enhanced the cortisol and norepinephrine concentrations in blood. Enlargement of the spleen was also found in the social defeat and "social threat" groups. At the immunological level (Experiment 4), the social defeat group showed lower levels of pro-inflammatory cytokines in the hypothalamus and hippocampus but higher concentration of IL-6 in the striatum compared to the other two groups. At the neurochemical level (Experiment 5), the socially defeated hamsters mainly displayed reductions of dopamine, dopamine metabolites, and 5-HT levels in the striatum and decreased level of 5-HT in the hippocampus. In Experiment 6, an increase in the spine density of hippocampal CA1 pyramidal neurons was specifically observed in the "social threat" group. Collectively, our findings indicate that repeated

  15. Repeated, Intermittent Social Defeat across the Entire Juvenile Period Resulted in Behavioral, Physiological, Hormonal, Immunological, and Neurochemical Alterations in Young Adult Male Golden Hamsters

    PubMed Central

    Yu, Wei-Chun; Liu, Ching-Yi; Lai, Wen-Sung

    2016-01-01

    The developing brain is vulnerable to social defeat during the juvenile period. As complements of human studies, animal models of social defeat provide a straightforward approach to investigating the functional and neurobiological consequences of social defeats. Taking advantage of agonist behavior and social defeat in male golden hamster, a set of 6 experiments was conducted to investigate the consequences at multiple levels in young adulthood resulting from repeated, intermittent social defeats or “social threats” across the entire juvenile period. Male hamsters at postnatal day 28 (P28) were randomly assigned to either the social defeat, “social threat”, or arena control group, and they correspondingly received a series of nine social interaction trials (i.e., either social defeat, “social threat”, or arena control conditions) from P33 to P66. At the behavioral level (Experiment 1), we found that repeated social defeats (but not “social threats”) significantly impacted locomotor activity in the familiar context and social interaction in the familiar/unfamiliar social contexts. At the physiological and hormonal levels (Experiments 2 and 3), repeated social defeat significantly enhanced the cortisol and norepinephrine concentrations in blood. Enlargement of the spleen was also found in the social defeat and “social threat” groups. At the immunological level (Experiment 4), the social defeat group showed lower levels of pro-inflammatory cytokines in the hypothalamus and hippocampus but higher concentration of IL-6 in the striatum compared to the other two groups. At the neurochemical level (Experiment 5), the socially defeated hamsters mainly displayed reductions of dopamine, dopamine metabolites, and 5-HT levels in the striatum and decreased level of 5-HT in the hippocampus. In Experiment 6, an increase in the spine density of hippocampal CA1 pyramidal neurons was specifically observed in the “social threat” group. Collectively, our

  16. Higher Education for Refugees: Lessons from a 4-Year Pilot Project

    ERIC Educational Resources Information Center

    Crea, Thomas M.; McFarland, Mary

    2015-01-01

    Refugees experience limited access to adequate education at all levels, but opportunities for higher education are especially lacking. Yet, evidence suggests that education plays an important protective role in helping refugee individuals and communities cope with their daily existence during protracted waiting periods, and the United Nations…

  17. Management of fascial space infections in a Nigerian teaching hospital: A 4-year review

    PubMed Central

    Osunde, Otasowie D.; Akhiwu, Benjamin I.; Efunkoya, Akinwale A.; Adebola, Adetokunbo R.; Iyogun, Cornelius A.; Arotiba, Juwon T.

    2012-01-01

    Background: Fascial space infections of the head and neck region, usually odontogenic in origin, are routinely treated as an out-patient procedure. Untreated or rapidly spreading odontogenic infections can be potentially life threatening. The present study is a review of patients with orofacial infections who required emergent incision and drainage in the maxillofacial unit of our institution. The need for early presentation is highlighted. Materials and Methods: This is a retrospective study of patients with orofacial space infections between January 2007 and December 2010. Patients’ case files were retrieved and demographic as well as clinical characteristics were obtained and analyzed. A P value of <0.05 was considered significant. Results: A total of 53 patients with fascial space infection were seen over the period of study. Of the 41 patients reviewed, males accounted for 26 (63.4%) and females 15 (36.6%). Their ages ranged from 4 months to 80 years (mean 32.8± 18.3 years). There was no statistical difference between the mean age of male and female patients (t=-962, P=0.342). Submandibular space was the most frequently involved single space and accounted for 43.9% of the cases. This was followed by multiple space involvement (Ludwig angina) which accounted for 36.6%. Buccal space and submasseteric space infection represented 7.3% each. Sources of infections were of odontogenic origin in 92.7% of cases and were unknown in the remaining 7.3%. The outcome was satisfactory with complete resolution in 48.8% of cases. Resolution with some morbidities in the form of persistent limitation of mouth opening, orocutaneus fistula, and necrotising fascitis were seen in an almost equal proportion of 46.3% of cases. The outcome was observed to be significantly associated with the presence of underlying systemic conditions (χ2 =21.66; r=0.73; P=0.0001), time of presentation (χ2 =12.28; r=0.55; P=0.002), and age (χ2 =54.48; r=0.69; P=0.0001). Conclusion: Fascial space

  18. Vertebral Osteomyelitis and Acinetobacter Spp. Paravertebral Soft Tissue Infection in a 4-Year-Old Boy With X-Linked Chronic Granulomatous Disease.

    PubMed

    Vignesh, Pandiarajan; Bhattad, Sagar; Shandilya, Jitendra-Kumar; Vyas, Sameer; Garg, Rashi; Rawat, Amit

    2016-09-01

    Vertebral osteomyelitis is known to occur in chronic granulomatous disease, a phagocytic disorder and the etiology is usually a fungus. Indolent spread of fungal infection from lungs to adjacent ribs and vertebra often results in persistent pneumonia and vertebral deformities. We report a 4-year-old boy with chronic cough and kyphosis, who had a fungal vertebral osteomyelitis and Acinetobacter spp. paravertebral soft tissue infection related to X-linked chronic granulomatous disease. PMID:27182896

  19. Tibial turn-up procedure as an alternative to rotationplasty in a 4-year-old with osteosarcoma of the distal femur.

    PubMed

    Tate, Rebecca; Gerrand, Craig; Hale, Juliet

    2015-01-01

    Reconstruction of the distal femur after resection for primary bone tumour in very young patients presents a considerable challenge. The risks and benefits of the available reconstructive options need to be carefully balanced. We report a case of osteosarcoma of the distal femur in a 4-year-old boy that was, unusually, treated by amputation and a tibial turn-up procedure; we discuss the rationale for the procedure and report the results at early follow-up. PMID:25305046

  20. The influence of peers on the tendency of 3- and 4-year-old children to over-imitate.

    PubMed

    McGuigan, Nicola; Robertson, Stacey

    2015-08-01

    Human children have frequently been shown to be high-fidelity imitators who faithfully reproduce the actions performed by a model. Curiously, children do not always appear to copy actions rationally and often copy in situations where doing so will lead to a reduction in task efficiency. This over-imitative tendency has been explored extensively with respect to adult models, but we know very little of the influence that peers can have on the fidelity of copying behavior. In an initial experiment, 3- and 4-year-old children watched two peers retrieve a reward from a puzzle box using a sequence of actions that were either causally relevant or causally irrelevant to reward retrieval. On completion of the task demonstrations, one model left the testing room, leaving the children to perform the task in the presence of the remaining efficient or inefficient peer. The results showed that, rather than copying the strategy of the peer who was physically present, the children displayed "blanket efficiency" and rarely reproduced the causally irrelevant actions. Intriguingly, the children switched from their previously efficient behavior when they were exposed to additional peer models who performed the causally irrelevant actions. The switch to an inefficient approach appeared to result from normative conformity because the children failed to reproduce the causally irrelevant actions when allowed to perform the task one final time in private. We suggest that the influence of the majority, although detrimental to task efficiency in this case, is a key cornerstone of human cultural evolution. PMID:25897959

  1. Evaluating the clinical utility of the Profile of Oral Narrative Ability for 4-year-old children.

    PubMed

    Westerveld, Marleen F; Gillon, Gail T; Boyd, Lynda

    2012-04-01

    This study investigated if the story retelling and comprehension task Ana Gets Lost, that is frequently used with school-aged children, has clinical utility with a preschool population. The study also assessed the task's concurrent and predictive validity with norm-referenced tests of language performance. A total of 92 typically-developing 4-year-old children participated. After 12 months, 57 children were available for a follow-up session. At each session, children listened twice to the story while looking at the pictures and then retold the story without the use of pictures. After the first exposure the children were asked comprehension questions to assess their oral narrative comprehension. Children's performance was analysed on measures of comprehension, narrative quality, semantics, morphosyntax, and verbal productivity to provide a Profile of Oral Narrative Ability (PONA). Results showed normal distribution of some of the measures and acceptable concurrent and predictive correlations with two norm-referenced measures of language ability. Although the results indicate the potential usefulness of this tool with preschool children, further research should investigate its potential as a screening measure of oral narrative performance. PMID:22204368

  2. Maternal child-feeding practices and dietary inadequacy of 4-year-old children.

    PubMed

    Durão, Catarina; Andreozzi, Valeska; Oliveira, Andreia; Moreira, Pedro; Guerra, António; Barros, Henrique; Lopes, Carla

    2015-09-01

    This study aimed to evaluate the association between maternal perceived responsibility and child-feeding practices and dietary inadequacy of 4-year-old children. We studied 4122 mothers and children enrolled in the population-based birth cohort - Generation XXI (Porto, Portugal). Mothers self-completed the Child Feeding Questionnaire and a scale on covert and overt control, and answered to a food frequency questionnaire in face-to-face interviews. Using dietary guidelines for preschool children, adequacy intervals were defined: fruit and vegetables (F&V) 4-7 times/day; dairy 3-5 times/day; meat and eggs 5-10 times/week; fish 2-4 times/week. Inadequacy was considered as below or above these cut-points. For energy-dense micronutrient-poor foods and beverages (EDF), a tolerable limit was defined (<6 times/week). Associations between maternal perceived responsibility and child-feeding practices (restriction, monitoring, pressure to eat, overt and covert control) and children's diet were examined by logistic regression models. After adjustment for maternal BMI, education, and diet, and children's characteristics (sex, BMI z-scores), restriction, monitoring, overt and covert control were associated with 11-18% lower odds of F&V consumption below the interval defined as adequate. Overt control was also associated with 24% higher odds of their consumption above it. Higher perceived responsibility was associated with higher odds of children consuming F&V and dairy above recommendations. Pressure to eat was positively associated with consumption of dairy above the adequate interval. Except for pressure to eat, maternal practices were associated with 14-27% lower odds of inadequate consumption of EDF. In conclusion, children whose mothers had higher levels of covert control, monitoring, and restriction were less likely to consume F&V below recommendations and EDF above tolerable limits. Higher overt control and pressure to eat were associated, respectively, with higher

  3. CONSTRAINTS ON LONG-PERIOD PLANETS FROM AN L'- AND M-BAND SURVEY OF NEARBY SUN-LIKE STARS: MODELING RESULTS

    SciTech Connect

    Heinze, A. N.; Hinz, Philip M.; Kenworthy, Matthew; Sivanandam, Suresh; Miller, Douglas; Meyer, Michael E-mail: phinz@as.arizona.ed E-mail: suresh@as.arizona.ed E-mail: mmeyer@phys.ethz.c

    2010-05-10

    We have carried out an L'- and M-band adaptive optics (AO) extrasolar planet imaging survey of 54 nearby, Sun-like stars using the Clio camera at the MMT. Our survey concentrates more strongly than all others to date on very nearby F, G, and K stars, in that we have prioritized proximity higher than youth. Our survey is also the first to include extensive observations in the M band, which supplemented the primary L' observations. These longer-wavelength bands are most useful for very nearby systems in which low-temperature planets with red IR colors (i.e., H - L', H - M) could be detected. The survey detected no planets, but set interesting limits on planets and brown dwarfs in the star systems we investigated. We have interpreted our null result by means of extensive Monte Carlo simulations and constrained the distributions of extrasolar planets in mass M and semimajor axis a. If planets are distributed according to a power law with dN {proportional_to} M {sup {alpha}} a {sup {beta}} dMda, normalized to be consistent with radial velocity (RV) statistics, we find that a distribution with {alpha} = -1.1 and {beta} = -0.46, truncated at 110 AU, is ruled out at the 90% confidence level. These particular values of {alpha} and {beta} are significant because they represent the most planet-rich case consistent with current statistics from RV observations. With 90% confidence no more than 8.1% of stars like those in our survey have systems with three widely spaced, massive planets like the A star HR 8799. Our observations show that giant planets in long-period orbits around Sun-like stars are rare, confirming the results of shorter-wavelength surveys and increasing the robustness of the conclusion.

  4. Implementation of an Aerosol-Cloud Microphysics-Radiation Coupling into the NASA Unified WRF: Simulation Results for the 6-7 August 2006 AMMA Special Observing Period

    NASA Technical Reports Server (NTRS)

    Shi, J. J.; Matsui, T.; Tao, W.-K.; Tan, Q.; Peters-Lidard, C.; Chin, M.; Pickering, K.; Guy, N.; Lang, S.; Kemp, E. M.

    2014-01-01

    Aerosols affect the Earth's radiation balance directly and cloud microphysical processes indirectly via the activation of cloud condensation and ice nuclei. These two effects have often been considered separately and independently, hence the need to assess their combined impact given the differing nature of their effects on convective clouds. To study both effects, an aerosol-microphysics-radiation coupling, including Goddard microphysics and radiation schemes, was implemented into the NASA Unified Weather Research and Forecasting model (NU-WRF). Fully coupled NU-WRF simulations were conducted for a mesoscale convective system (MCS) that passed through the Niamey, Niger area on 6-7 August 2006 during an African Monsoon Multidisciplinary Analysis (AMMA) special observing period. The results suggest that rainfall is reduced when aerosol indirect effects are included, regardless of the aerosol direct effect. Daily mean radiation heating profiles in the area traversed by the MCS showed the aerosol (mainly mineral dust) direct effect had the largest impact near cloud tops just above 200 hectopascals where short-wave heating increased by about 0.8 Kelvin per day; the weakest long-wave cooling was at around 250 hectopascals. It was also found that more condensation and ice nuclei as a result of higher aerosol/dust concentrations led to increased amounts of all cloud hydrometeors because of the microphysical indirect effect, and the radiation direct effect acts to reduce precipitating cloud particles (rain, snow and graupel) in the middle and lower cloud layers while increasing the non-precipitating particles (ice) in the cirrus anvil. However, when the aerosol direct effect was activated, regardless of the indirect effect, the onset of MCS precipitation was delayed about 2 hours, in conjunction with the delay in the activation of cloud condensation and ice nuclei. Overall, for this particular environment, model set-up and physics configuration, the effect of aerosol

  5. Men's Understanding of and Experiences During the Postcircumcision Abstinence Period: Results From a Field Study of ShangRing Circumcision During Routine Clinical Services in Kenya and Zambia

    PubMed Central

    Li, Philip S.; Zulu, Robert; Awori, Quentin D.; Agot, Kawango; Combes, Stephanie; Simba, Raymond O.; Lee, Richard K.; Hart, Catherine; Lai, Jaim Jou; Zyambo, Zude; Goldstein, Marc; Feldblum, Paul J.; Sokal, David C.

    2016-01-01

    Background: Men's understanding of counseling messages after voluntary medical male circumcision (VMMC) plays an important role in whether they follow them. Data on triggers for early resumption of sex may be useful as scale-up of VMMC for HIV prevention continues in sub-Saharan Africa. Methods: Data on understanding of post-VMMC abstinence recommendations, resumption of sex, condom use, and triggers for resuming sex were collected from participants during a follow-up interview 35–42 days after ShangRing circumcision in Kenya and Zambia. Results: Of 1149 men who had ShangRing circumcision, 1096 (95.4%) completed follow-up. Nearly all (99.2%) reported being counseled to abstain from sex post-VMMC; among those, most (92.2%) recalled the recommended abstinence period was 6 weeks. Most men (94.1%) reported that the counselor gave reasons for post-VMMC abstinence and recalled appropriate reasons. Few (13.4%) men reported resuming sex at 35–42 days' follow-up. Among those, 54.8% reported never using a condom post-VMMC. Younger participants (odds ratio 0.3, 95% confidence interval: 0.2 to 0.5, P < 0.0001) and those reporting at least some condom use at baseline (odds ratio 0.5, 95% confidence interval: 0.3 to 0.7, P = 0.0003) were less likely to report resuming sex. Among men who reported some condom use, most (71.5%) said condoms were much easier or easier to use after circumcision. Men reported various reasons for early resumption of sex, primarily strong sexual desire (76.4%). Conclusions: Most men reported awareness of and adherence to the counseling recommendations for post-VMMC abstinence. A minority reported early resumption of sex, and, among those, condom use was low. Results could be used to improve post-VMMC counseling. PMID:27331585

  6. Vehicle child restraint usage for Pacific children aged 6 weeks to 4 years: findings from the Pacific Islands Families study.

    PubMed

    Schluter, Philip J; Paterson, Janis

    2010-11-01

    Child restraint systems (CRSs) for vehicles are designed to provide protection and prevent or reduce child mortality and morbidity in road traffic accidents. Overall, 90% of children under 5 years of age in New Zealand currently use CRSs. There is considerable regional variability in CRS usage, but little information exists on its ethnic variations or determinants. "Increasing the level of restraint use" is explicitly stated as one of the 13 priorities within the New Zealand Ministry of Transport's new road safety strategy. As such, understanding CRS prevalence, patterns and associates within different communities is essential in realising this priority. Utilising a large birth cohort of Pacific children (n=1376 mothers), this study aimed to report the prevalence of maternal self-reported car seat usage at the 6 weeks, 1-year, and 2 years postpartum measurement waves; car/booster seat usage at the 4 years postpartum measurement wave; and to identify important associates using generalised estimating equation (GEE) models. Car seats were not used by 161 (11.8%) Pacific children at the 6 weeks measurement wave, 71 (5.8%) at 1-year, and 44 (3.8%) at 2 years, while car/booster seats were not used by 139 (13.3%) at the 4 years wave. Multivariable GEE model results revealed that mothers with no formal education, high parity, who smoked tobacco, lower household income, who lacked English language proficiency, and had multiple births were all at higher odds of failing to use car seat/booster seats. Despite differential attrition being noted in mothers over time, a sensitivity analysis using multiple imputation methods yielded similar findings. Targeted initiatives and education programs focusing on these higher risk groups, in particular, is needed to increase uptake and use of CRS thereby decreasing Pacific children's exposure to injury risk. As New Zealand has a large and increasing proportion of Pacific, Maori and Asian people, there is a continuing need to understand

  7. Risk factors for Mycobacterium tuberculosis infection in 2–4 year olds in a rural HIV-prevalent setting

    PubMed Central

    Glynn, J. R.; Fielding, K. L.; Mzembe, T.; Mulawa, D.; Chiumya, R.; Fine, P. E. M.; Koole, O.; Kranzer, K.; Crampin, A. C.

    2016-01-01

    SUMMARY BACKGROUND: Mycobacterium tuberculosis infection in children acts as a sentinel for infectious tuberculosis. OBJECTIVE: To assess risk factors associated with tuberculous infection in pre-school children. METHOD: We conducted a population-wide tuberculin skin test (TST) survey from January to December 2012 in Malawi. All children aged 2–4 years residing in a demographic surveillance area were eligible. Detailed demographic data, including adult human immunodeficiency virus (HIV) status, and clinical and sociodemographic data on all diagnosed tuberculosis (TB) patients were available. RESULTS: The prevalence of M. tuberculosis infection was 1.1% using a TST induration cut-off of 15 mm (estimated annual risk of infection of 0.3%). The main identifiable risk factors were maternal HIV infection at birth (adjusted OR [aOR] 3.6, 95%CI 1.1–12.2), having three or more adult members in the household over a lifetime (aOR 2.4, 95%CI 1.2–4.8) and living in close proximity to a known case of infectious TB (aOR 1.6, 95%CI 1.1–2.4), modelled as a linear variable across categories (>200 m, 100–200 m, <100 m, within household). Less than 20% of the infected children lived within 200 m of a known diagnosed case. CONCLUSION: Household and community risk factors identified do not explain the majority of M. tuberculosis infections in children in our setting. PMID:27046715

  8. The perception of science department chairs regarding the performance of community college science majors transferring to 4-year institutions

    NASA Astrophysics Data System (ADS)

    Ford, Brenda Jordan

    The purpose for conducting the study was to determine the perceptions held by science department chairs toward 2-year college transfer students regarding their ability to succeed in upper level science courses as compared to that of native students. A two-section, researcher-developed questionnaire was utilized to collect data. The first section was related to demographic information about the department chair's institution, such as institution size, number of transfer students at the institution, and the post-graduate plans of students. The second section presented 15 skills that if found in students should lead to academic success. A total of 61 (N = 61) surveys were returned, representing an overall return rate of 54.4%. The mean, the standard deviation, and paired t-tests were used to analyze the data. Results showed that science department chairs perceived significant differences in native and transfer students. The significant differences found between native and transfer students became greater as the size of the institution increased. The significant differences found between native and transfer students became less the greater the number of transfer students attending an institution. Significant differences were found between students planning to attend professional school and students going to jobs after graduation. No significant differences were found between students going to graduate school and those who were undecided about post-graduation plans. Two-year college transfer students were perceived by department chairs as having the ability to be academically successful at 4-year institutions.

  9. Hematogones With Lambda Light Chain Restriction in a 4-Year-Old Boy With Burkitt Lymphoma: A Potential Diagnostic Pitfall.

    PubMed

    Guillory, Tesha; Li, Shiyong; Bergsagel, Daniel J; Weinzierl, Elizabeth; Bunting, Silvia T

    2016-05-01

    Hematogones are immature normal B cell precursors with a characteristic immunophenotype profile on flow cytometry that typically do not express surface immunoglobulin light chains. In this report, we describe a case in which the hematogones exhibit light chain restriction. Our patient was a 4-year-old boy with a complicated medical history involving treatment for a presumed bilateral Wilms tumor of the kidney that on later resection was diagnosed as Burkitt lymphoma. Flow cytometry analysis of his bone marrow revealed a small distinct population of cells expressing dim cluster of differentiation (CD)10, CD19, CD22, CD38, dim CD58, human leukocyte antigen-D related (HLA-DR), and dim CD45, which are characteristic of hematogones. These cells, however, demonstrated dim surface immunoglobulin lambda light-chain restriction. Molecular study results for immunoglobulin heavy and kappa light-chain gene rearrangements were negative. We present this case to raise awareness of the potential pitfalls of working up bone marrow for involvement by B cell lymphoproliferative disorder. PMID:27069035

  10. Metagenomic analysis on seasonal microbial variations of activated sludge from a full-scale wastewater treatment plant over 4 years.

    PubMed

    Ju, Feng; Guo, Feng; Ye, Lin; Xia, Yu; Zhang, Tong

    2014-02-01

    Metagenomic technique was employed to characterize the seasonal dynamics of activated sludge (AS) communities in a municipal wastewater treatment plant (WWTP) over 4 years. The results indicated that contrary to Eukaryota (mainly Rotifera and Nematoda), abundances of Bacteria and Archaea (mainly Euryarchaeota) were significantly higher in winter than summer. Two-way analysis of variance and canonical correspondence analysis revealed that many functionally important genera followed strong seasonal variation patterns driven by temperature and salinity gradients; among them, two nitrifying bacteria, Nitrospira and Nitrosomonas, displayed much higher abundances in summer, whereas phosphate-removing genus Tetrasphaera, denitrifier Paracoccus and potential human faecal bacteria, i.e. Bifidobacterium, Dorea and Ruminococcus, showed significantly higher abundances in winter. Particularly, occurrence of dual variation patterns beyond explanation merely by seasonality indicated that multivariables (e.g. dissolved oxygen, sludge retention time, nutrients) participated in shaping AS community structure. However, SEED subsystems annotation showed that functional categories in AS showed no significant difference between summer and winter, indicating that compared with its microbial components, the functional profiles of AS were much more stable. Taken together, our study provides novel insights into the microbial community variations in AS and discloses their correlations with influential factors in WWTPs. PMID:24596265

  11. Hematogones With Lambda Light Chain Restriction in a 4-Year-Old Boy With Burkitt Lymphoma: A Potential Diagnostic Pitfall

    PubMed Central

    Guillory, Tesha; Li, Shiyong; Bergsagel, Daniel J.; Weinzierl, Elizabeth; Bunting, Silvia T.

    2016-01-01

    Hematogones are immature normal B cell precursors with a characteristic immunophenotype profile on flow cytometry that typically do not express surface immunoglobulin light chains. In this report, we describe a case in which the hematogones exhibit light chain restriction. Our patient was a 4-year-old boy with a complicated medical history involving treatment for a presumed bilateral Wilms tumor of the kidney that on later resection was diagnosed as Burkitt lymphoma. Flow cytometry analysis of his bone marrow revealed a small distinct population of cells expressing dim cluster of differentiation (CD)10, CD19, CD22, CD38, dim CD58, human leukocyte antigen–D related (HLA-DR), and dim CD45, which are characteristic of hematogones. These cells, however, demonstrated dim surface immunoglobulin lambda light-chain restriction. Molecular study results for immunoglobulin heavy and kappa light-chain gene rearrangements were negative. We present this case to raise awareness of the potential pitfalls of working up bone marrow for involvement by B cell lymphoproliferative disorder. PMID:27069035

  12. Changes in Maternal Plasma Adiponectin from Late Pregnancy to the Postpartum Period According to the Mode of Delivery: Results from a Prospective Cohort in Rio de Janeiro, Brazil

    PubMed Central

    Rebelo, Fernanda; Franco-Sena, Ana Beatriz; Struchiner, Claudio Jose; Kac, Gilberto

    2016-01-01

    Introduction Maternal plasma adiponectin is inversely related to insulin resistance, atherosclerosis and child health. However, little is known about its concentrations in the perinatal period, especially according to mode of delivery. Our aim is to evaluate the association between mode of delivery and changes in maternal plasma adiponectin from 3rd trimester of pregnancy to 30–45 days postpartum. Methods A cohort was recruited in Rio de Janeiro, Brazil, with four waves of follow-up: 5-13th, 22-26th, 30-36th gestational weeks and 30–45 days postpartum. Eligible subjects should be between 20–40 years of age, be free of chronic and infectious diseases and presenting with a singleton pregnancy. The mode of delivery was classified as vaginal (VD) or cesarean (CS). Plasma adiponectin concentration (μg/mL) was measured using commercial ELISA kits. Statistical analyses included the Wilcoxon rank-sum test and the multiple linear mixed effects model. Results A total of 159 participated in the study. Median adiponectin concentrations were higher for the VD group (n = 99; 8.25, IQR: 5.85–11.90) than for the CS group (n = 60; 7.34, IQR: 4.36–9.76; p = 0.040) in the postpartum samples but were not different between the two groups in the 3rd trimester. Women who underwent CS had a lower rate of increase in adiponectin concentration from the 3rd trimester to 30–45 days postpartum compared to those who underwent VD (β = -.15, 95% CI: -.28-.02, p = 0.030). Conclusion The CS procedure was associated with lower maternal circulating concentrations of adiponectin at 30–45 days postpartum, compared to the VD. PMID:27391647

  13. Development of venous thromboembolism (VTE) in patients undergoing surgery for brain tumors: results from a single center over a 10 year period.

    PubMed

    Smith, Timothy R; Nanney, Allan D; Lall, Rishi R; Graham, Randall B; McClendon, Jamal; Lall, Rohan R; Adel, Joseph G; Zakarija, Anaadriana; Cote, David J; Chandler, James P

    2015-03-01

    Patients who undergo craniotomy for brain neoplasms have a high risk of developing venous thromboembolism (VTE), including deep vein thromboses (DVT) and pulmonary emboli (PE). The reasons for this correlation are not fully understood. This retrospective, single-center review aimed to determine the risk factors for VTE in patients who underwent neurosurgical resection of brain tumors at Northwestern University from 1999 to 2010. Our cohort included 1148 patients, 158 (13.7%) of whom were diagnosed with DVT and 38 (3.3%) of whom were diagnosed with PE. A variety of clinical factors were studied to determine predictors of VTE, including sex, ethnicity, medical co-morbidities, surgical positioning, length of hospital stay, tumor location, and tumor histology. Use of post-operative anticoagulants and hemorrhagic complications were also investigated. A prior history of VTE was found to be highly predictive of post-operative DVT (odds ratio [OR]=7.6, p=0.01), as was the patient's sex (OR=14.2, p<0.001), ethnicity (OR=0.5, p=0.04), post-operative intensive care unit days (OR=0.2, p=0.003), and tumor histology (OR=-0.16, p=0.01). Contrary to reports in the literature, the data collected did not indicate that the administration of post-operative medical prophylaxis for VTE was significant in preventing their formation (OR=-0.14, p=0.76). Hemorrhagic complications were low (2.2%) and resultant neurologic deficit was lower still (0.7%). The study indicates that patients with high-grade primary brain tumors and metastatic lesions should receive aggressive preventative measures in the post-operative period. PMID:25533212

  14. A 4 year follow-up study of alveolar bone height influenced by two dissimilar Class II amalgam restorations.

    PubMed

    Fisher, D; Markitziu, A; Fishel, D; Brayer, L

    1984-07-01

    Fifty-four paired, approximal amalgam fillings, extended (E) versus unextended (NE) were placed in forty-three patients and followed up to 4 years. Yearly measurements between the alveolar crest and (a) the apical margin of the fillings (E, NE), and (b) the cemento-enamel junction of the control group, were performed using bite-wing radiographs joined to a translucent grid magnified ten-fold. The rate of alveolar crest resorption was similar for the control (C) and the unextended filling (NE) and reached 0.45 mm after 4 years of follow-up. The resorption of the alveolar crest under the extended (E) filling was significantly higher and reached 0.80 mm after 4 years (P less than 0.001). PMID:6589386

  15. Irregular Periods

    MedlinePlus

    ... number of days after the last one. The Menstrual Cycle Most girls get their first period between the ... to skip periods or to have an irregular menstrual cycle. Illness, rapid weight change, or stress can also ...

  16. Women’s Satisfaction with Body Image before Pregnancy and Body Mass Index 4 Years after Delivery in the Mothers of Generation XXI

    PubMed Central

    Henriques, Ana; Alves, Elisabete; Barros, Henrique; Azevedo, Ana

    2013-01-01

    Background Body image satisfaction (BIS) influences body weight regulation and may contribute to long-term healthier lifestyle after pregnancy. Thus, we aimed to assess the association between BIS before pregnancy and body mass index (BMI) 4 years after the index pregnancy. Methods As part of the follow-up of a birth cohort, 3612 women with prepregnancy BMI >18.5 kg/m2 were reevaluated 4 years after the birth of a child. BIS was defined as the difference between perceived and ideal body size before pregnancy, assessed by Stunkard Silhouettes after birth. The associations of BIS with BMI change (continuous) and BMI classes at 4 years, based on measured weight and height, were estimated using linear and multinomial regression, respectively. Results Among women with normal prepregnancy BMI, those who felt too small, regarding their ideal, had a 0.25 kg/m2 smaller increase in BMI within 4 years and a lower likelihood of becoming overweight or obese [multivariate-adjusted odds ratio (OR) = 0.63; 95% confidence interval (95%CI): 0.44–0.91 and OR = 0.21; 95%CI: 0.05–0.91, respectively) than those satisfied with body image. Feeling too large was associated with a 0.41 kg/m2 larger increase in BMI and a higher risk of becoming overweight or obese (OR = 2.12; 95%CI:1.73–2.59 and OR = 3.42; 95%CI:2.02–5.79, respectively). A similar, non-significant, trend was observed for overweight women. Obese women who felt too large had a non-significant decrease in BMI. Conclusions BIS plays a role in maternal body weight after delivery. Realistic body size goals may promote the motivation to lose weight and contribute to higher success in attaining them. PMID:23936169

  17. Argus II retinal prosthesis implantation with scleral flap and autogenous temporalis fascia as alternative patch graft material: a 4-year follow-up

    PubMed Central

    Matet, Alexandre; Amar, Nawel; Mohand-Said, Saddek; Sahel, José-Alain; Barale, Pierre-Olivier

    2016-01-01

    Introduction The Argus II retinal prosthesis is composed of an epiretinal electrode array positioned over the macula and connected to an extrascleral electronics case via a silicone cable, running through a sclerotomy. During implantation, the manufacturer recommends to cover the sclerotomy site with a patch of processed human pericardium to prevent postoperative hypotony and conjunctival erosion by the underlying electronics case. Due to biomedical regulations prohibiting the use of this material in France, we developed an alternative technique combining a scleral flap protecting the sclerotomy and an autogenous graft of superior temporalis fascia overlying the electronics case. Methods The purpose of this study is to describe the 4-year outcomes of this modified procedure in three subjects who underwent Argus II Retinal Prosthesis System implantation. Clinical data consisting of intraocular pressure measurements and tolerance in terms of conjunctival erosion or inflammation were retrospectively assessed over a 4-year postoperative follow-up. Results None of the three patients implanted with the modified technique developed ocular hypotony over 4 years. A normal, transient conjunctival inflammation occurred during the first postoperative month but conjunctival erosion was not observed in any of the three patients over 4 years. Four years after implantation, the autogenous temporalis fascia graft remained well tolerated and the retinal prosthesis was functional in all three patients. Conclusion The combination of an autograft of superficial temporalis fascia and a scleral flap efficiently prevented leakage through the sclerotomy site, ocular hypotony, and conjunctival erosion by the extrascleral electronics case. This modified technique is suitable for the implantation of existing and forthcoming retinal prostheses. Superficial temporalis fascia may also be used as alternative to commercial tectonic tissues for scleral wound repair in clinical settings where they

  18. Understanding young adult physical activity, alcohol and tobacco use in community colleges and 4-year post-secondary institutions: A cross-sectional analysis of epidemiological surveillance data

    PubMed Central

    2010-01-01

    Background Young adults experience many adverse health behavior changes as they transition from adolescence into adulthood. A better understanding of the relationships between health promoting and risky health behaviors may aid in the development of health promotion interventions for various types of young adult post-secondary students. Therefore, the purpose of this study was to examine associations between alcohol and tobacco use and physical activity among 2-year and 4-year college students. Methods Cross-sectional analyses were conducted using 2007 survey data, collected as part of an on-going post-secondary health surveillance system in Minnesota. Students were randomly selected to participant from 14 Minnesota colleges and universities (six 2-year community and/or technical colleges, eight 4-year post-secondary institutions). The 2007 surveillance data included 9,931 respondents. Results The prevalence of demographic characteristics and health behaviors (e.g., physical activity, tobacco use) differed between young adults attending 2-year and 4-year post-secondary institutions; in general, those attending 2-year institutions are representative of more at-risk populations. Overall, higher levels of moderate, vigorous and strengthening physical activity were associated with higher levels of alcohol consumption and lower levels of smoking. In general, despite the disparities in the prevalence of these risk behaviors, the associations between the behaviors did not differ substantially between 2-year and 4-year post-secondary populations. Conclusions These findings illustrate links between leading risk behaviors. Interventions targeting multiple risk behaviors among young adults may warrant further consideration. Overall, future research is needed to support and inform young adult health promotion efforts that may be implemented in a wide array of post-secondary institutions. PMID:20420678

  19. Parental phonological memory contributes to prediction of outcome of late talkers from 20 months to 4 years: a longitudinal study of precursors of specific language impairment

    PubMed Central

    2012-01-01

    Background Many children who are late talkers go on to develop normal language, but others go on to have longer-term language difficulties. In this study, we considered which factors were predictive of persistent problems in late talkers. Methods Parental report of expressive vocabulary at 18 months of age was used to select 26 late talkers and 70 average talkers, who were assessed for language and cognitive ability at 20 months of age. Follow-up at 4 years of age was carried out for 24 late and 58 average talkers. A psychometric test battery was used to categorize children in terms of language status (unimpaired or impaired) and nonverbal ability (normal range or more than 1 SD below average). The vocabulary and non-word repetition skills of the accompanying parent were also assessed. Results Among the late talkers, seven (29%) met our criteria for specific language impairment (SLI) at 4 years of age, and a further two (8%) had low nonverbal ability. In the group of average talkers, eight (14%) met the criteria for SLI at 4 years, and five other children (8%) had low nonverbal ability. Family history of language problems was slightly better than late-talker status as a predictor of SLI.. The best predictors of SLI at 20 months of age were score on the receptive language scale of the Mullen Scales of Early Learning and the parent's performance on a non-word repetition task. Maternal education was not a significant predictor of outcome. Conclusions In this study, around three-quarters of late talkers did not have any language difficulties at 4 years of age, provided there was no family history of language impairment. A family history of language-literacy problems was found to be a significant predictor for persisting problems. Nevertheless, there are children with SLI for whom prediction is difficult because they did not have early language delay. PMID:22958373

  20. Remission in schizophrenia: results of cross-sectional with 6-month follow-up period and 1-year observational therapeutic studies in an outpatient population

    PubMed Central

    2012-01-01

    Background A standardized definition of remission criteria in schizophrenia was proposed by the International group of NC Andreasen in 2005 (low symptom threshold for the eight core Positive and Negative Syndrome Scale (PANSS) symptoms for at least 6 consecutive months). Methods A cross-sectional study of remission rate, using a 6-month follow-up to assess symptomatic stability, was conducted in two healthcare districts (first and second) of an outpatient psychiatric service in Moscow. The key inclusion criteria were outpatients with an International Classification of Diseases, 10th edition (ICD-10) diagnosis of schizophrenia or schizoaffective disorder. Remission was assessed using modern criteria (severity and time criteria), PANSS and Global Assessment of Functioning (GAF). Patients who were stable but did not satisfied the symptomatic criteria were included in a further 1-year observational study, with the first group (first district) receiving risperidone (long-acting, injectable) (RLAI) and the second group (second district) continuing to receiving routine treatment. Symptoms were assessed with PANSS, social functioning with the personal and social performance scale, compliance with rating of medication influences scale, and extrapyramidal side effects with the Simpson-Angus scale. Results Only 64 (31.5%) of 203 outpatients met the criteria for symptomatic remission in the cross-sectional study, but at the end of the 6-month follow-up period, 158 (77.8%) were stable (irrespective of remission status). Among these only 53 (26.1%) patients fulfilled the remission criteria. The observational study had 42 stable patients in the RLAI group and 35 in the routine treatment group: 19.0% in the RLAI group and 5.7% in the control group met remission criteria after 12 months of therapy. Furthermore, reduction of PANSS total and subscale scores, as well as improvement in social functioning, was more significant in the first group. Conclusions Only around one-quarter of

  1. New results to discuss possibility of irrigation in Bat (Wadi Sharsah, northwestern Oman) before Hafit period (ca. 3100-2700 BCE)

    NASA Astrophysics Data System (ADS)

    Fouache, Eric; Desruelles, Stéphane; Eddargach, Wassel; Cammas, Cecilia; Wattez, Julia; Martin, Chloé; Tengberg, Margareta; Beuzen-Waller, Tara; Cable, Charlotte; Thornton, Christopher

    2014-05-01

    Registered as a World Heritage Site by UNESCO in 1989, the extensive archaeological site of Bat is situated within the Wadi Sharsah and around the modern village and palm grove of Bat, 24 km from the modern city of Ibri in northwestern Oman. The archaeological remains from the Bronze Age excavated by the Bat Archaeological Project are located in two mains areas. The northern area consists of a chain of low limestone hills cut by wadi tributaries leading to the main Wadi Sharsah. It is characterised by an exceptionnally high density of graves from two successive Bronze Age periods : Hafit (ca. 3100-2700 BCE) and Umm an-Nar (ca. 2700-2000 BCE). South of the Bat cemetery, in the flat part of the valley, there are several large circular structures (known historically as « towers ») and remains from both Hafit and Umm an-Nar periods, as well as later periods. Geomorphological mapping of the floodplain, associated with archaeological survey, have identified walls suggesting that during the Umm an-Nar period there was a system of irrigation which controlled flood water. Sedimentological, malacological, C14 dating and micromorphological studies of a 10 m long and 2.5 m high section located 143 m northeast of the Tower 1146 on the left bank of a small tributary of the Wadi Sharsah provide strong argument for the presence of an irrigation system that began before the Hafit period. New C14 datings confirm this hypothesis. Botanical macro-remains collected during the excavation of early Bronze Age structures at Bat further indicate the presence of date palm gardens since the 3rd millenium BCE allowing the cultivation of several crop species, in particular cereals. Most generally the global palaeoenvironmental reconstruction from our data supports a model of a general trend of aridification from Bronze Age to iron Age. Key words : Bronze Age, Holocene, Geomoephology, Micromorphology, Irrigation, Oman.

  2. Toward standard HER2 testing of endometrial serous carcinoma: 4-year experience at a large academic center and recommendations for clinical practice.

    PubMed

    Buza, Natalia; English, Diana P; Santin, Alessandro D; Hui, Pei

    2013-12-01

    HER2 overexpression and/or amplification have been reported in endometrial serous carcinoma, suggesting that HER2 may be a promising therapeutic target. However, there is considerable variation in the reported rates of HER2 overexpression and amplification, likely--at least in part--resulting from variability in the testing methods, interpretation, and scoring criteria used. Unlike in breast and gastric cancer, currently there are no established guidelines for HER2 testing in endometrial carcinoma. A total of 108 endometrial carcinoma cases--85 pure serous carcinomas and 23 mixed endometrial carcinomas with serous component--were identified over a 4-year period. All H&E and HER2 immunohistochemical slides were reviewed and HER2 FISH results (available on 52 cases) were retrieved from pathology reports. HER2 immunohistochemical scores were assigned according to the FDA criteria and the current breast ASCO/CAP scoring criteria. Clinical information was retrieved from the patients' medical records. Thirty-eight cases (35%) showed HER2 overexpression and/or gene amplification, 20 of which (53%) had significant heterogeneity of protein expression by immunohistochemistry. Lack of apical membrane staining resulting in a lateral/basolateral staining pattern was observed in the majority of HER2-positive tumors. Five of the HER2-positive cases (13%) demonstrated discrepant immunohistochemical scores when using the FDA versus ASCO/CAP scoring system. The overall concordance rate between HER2 immunohistochemistry and FISH was 75% (39/52) when using the FDA criteria, compared with 81% (42/52) by the ASCO/CAP scoring system. In conclusion, in this largest comprehensive study, 35% of endometrial serous carcinoma harbors HER2 protein overexpression and/or gene amplification, over half of which demonstrate significant heterogeneity of protein expression. The current breast ASCO/CAP scoring criteria provide the highest concordance between immunohistochemistry and FISH. Assessment of

  3. Impact of hypothyroidism on the development of non-alcoholic fatty liver disease: A 4-year retrospective cohort study

    PubMed Central

    Lee, Kil Woo; Bang, Ki Bae; Rhee, Eun Jung; Kwon, Heon Ju; Lee, Mi Yeon

    2015-01-01

    Background/Aims Hypothyroidism is reported to contribute to the development of nonalcoholic fatty liver disease (NAFLD). We compared the risk of the development of NAFLD among three groups with different thyroid hormonal statuses (control, subclinical hypothyroidism, and overt hypothyroidism) in a 4-year retrospective cohort of Korean subjects. Methods Apparently healthy Korean subjects without NAFLD and aged 20-65 years were recruited (n=18,544) at health checkups performed in 2008. Annual health checkups were applied to the cohort for 4 consecutive years until December 2012. Based on their initial serum-free thyroxine (fT4) and thyroid-stimulating hormone (TSH) levels, they were classified into control, subclinical hypothyroidism (TSH >4.2 mIU/L, normal fT4), and overt hypothyroidism (TSH >4.2 mIU/L, fT4 <0.97 ng/dL) groups. NAFLD was diagnosed on the basis of ultrasonography findings. Results NAFLD developed in 2,348 of the 18,544 subjects, representing an overall incidence of 12.7%: 12.8%, 11.0%, 12.7% in the control, subclinical hypothyroidism, and overt hypothyroidism groups, respectively. The incidence of NAFLD did not differ significantly with the baseline thyroid hormonal status, even after multivariate adjustment (subclinical hypothyroidism group: hazard ratio [HR]=0.965, 95% confidence interval [CI]=0.814-1.143, P=0.67; overt hypothyroidism group: HR=1.255, 95% CI=0.830-1.899, P=0.28). Conclusions Our results suggest that the subclinical and overt types of hypothyroidism are not related to an increased incidence of NAFLD. PMID:26770926

  4. Criterion validity of a competency-based assessment center in medical education – a 4-year follow-up study

    PubMed Central

    Rotthoff, Thomas; Ostapczuk, Martin S.; Kröncke, Klaus D.; Zimmerhofer, Alexander; Decking, Ulrich; Schneider, Matthias; Ritz-Timme, Stefanie

    2014-01-01

    Introduction Core competencies have progressively gained importance in medical education. In other contexts, especially personnel selection and development, assessment centers (ACs) are used to assess competencies, but there is only a limited number of studies on competency-based ACs in medical education. To the best of our knowledge, the present study provides the first data on the criterion-related validity of a competency-based AC in medical education. Methods We developed an AC tailored to measure core competencies relevant to medical education (social-ethical, communicative, self, and teaching) and tested its validity in n=30 first-year medical students using 3- to 4-year follow-up measures such as (a) objective structured clinical examinations (OSCE) on basic clinical skills (n=26), (b) OSCE on communication skills (n=21), and (c) peer feedback (n=18). The AC contained three elements: interview, group discussion, and role play. Additionally, a self-report questionnaire was provided as a basis for the interview. Results Baseline AC average score and teaching competency correlated moderately with the communication OSCE average score (r=0.41, p=0.03, and r=0.38, p=0.04, respectively). Social-ethical competency in the AC showed a very strong convergent association with the communication OSCE average score (r=0.60, p<0.01). The AC total score also showed a moderate correlation with the overall peer feedback score provided in Year 4 (r=0.38, p=0.06). In addition, communicative competency correlated strongly with the overall peer feedback (r=0.50, p=0.02). We found predominantly low and insignificant correlations between the AC and the OSCE on basic clinical skills (r=−0.33 to 0.30, all p's>0.05). Conclusion The results showed that competency-based ACs can be used at a very early stage of medical training to successfully predict future performance in core competencies. PMID:25219931

  5. Integrating Research-Informed Teaching within an Undergraduate Level 4 (Year 1) Diagnostic Radiography Curriculum: A Pilot Study

    ERIC Educational Resources Information Center

    Higgins, Robert; Hogg, Peter; Robinson, Leslie

    2013-01-01

    This article discusses the piloting and evaluation of the Research-informed Teaching experience (RiTe) project. The aim of RiTe was to link teaching and learning with research within an undergraduate diagnostic radiography curriculum. A preliminary pilot study of RiTe was undertaken with a group of level 4 (year 1) volunteer BSc (Hons) diagnostic…

  6. Different Executive Functions Support Different Kinds of Cognitive Flexibility: Evidence from 2-, 3-, and 4-Year-Olds

    ERIC Educational Resources Information Center

    Blakey, Emma; Visser, Ingmar; Carroll, Daniel J.

    2016-01-01

    Improvements in cognitive flexibility during the preschool years have been linked to developments in both working memory and inhibitory control, though the precise contribution of each remains unclear. In the current study, one hundred and twenty 2-, 3-, and 4-year-olds completed two rule-switching tasks. In one version, children switched rules in…

  7. The Prevalence of ADHD, ODD, Depression, and Anxiety in a Community Sample of 4-Year-Olds

    ERIC Educational Resources Information Center

    Lavigne, John V.; LeBailly, Susan A.; Hopkins, Joyce; Gouze, Karen R.; Binns, Helen J.

    2009-01-01

    Few studies have examined the epidemiology of preschoolers' psychopathology. This study included 796 4-year-old children recruited from schools and pediatric practices in a diverse, urban area. Psychiatric disorder was assessed by a structured interview adapted for preschool children and by questionnaire. The most common disorders were…

  8. Effectiveness of a Fundamental Motor Skill Intervention for 4-Year-Old Children with Autism Spectrum Disorder: A Pilot Study

    ERIC Educational Resources Information Center

    Bremer, Emily; Balogh, Robert; Lloyd, Meghann

    2015-01-01

    A wait-list control experimental design was employed to investigate the effectiveness of a fundamental motor skill intervention at improving the motor skills, adaptive behavior, and social skills of 4-year-old children with autism spectrum disorder (experimental n?=?5, control n?=?4); the impact of intervention intensity was also explored. The…

  9. CO2 AND N-FERTILIZATION EFFECTS ON FINE ROOT LENGTH, PRODUCTION, AND MORTALITY: A 4-YEAR PONDEROSA PINE STUDY

    EPA Science Inventory

    We conducted a 4-year study of Pinus ponderosa fine root (<2 mm) responses to atmospheric CO2 and N-fertilization. Seedlings were grown in open-top chambers at 3 CO2 levels (ambient, ambient+175 mol/mol, ambient+350 mol/mol) and 3 N-fertilization levels (0, 10, 20 g?m-2?yr-1). ...

  10. Factors Influencing Childcare Workers' Promotion of Physical Activity in Children Aged 0-4 Years: A Qualitative Study

    ERIC Educational Resources Information Center

    Wilke, Sarah; Opdenakker, Claudia; Kremers, Stef P. J; Gubbels, Jessica S

    2013-01-01

    The present study examined the factors influencing childcare workers' promotion of physical activity (PA) among children aged 0-4?years, a particularly interesting context because of the increasing number of children attending childcare. Twenty Dutch childcare workers were interviewed. The interviews revealed some important barriers to the…

  11. Transfer and Graduation Rates, Full-Time Entrants after 4 Years. Revised Brief RB93-16.

    ERIC Educational Resources Information Center

    Clagett, Craig A.

    Drawing from annual data provided by the Maryland Higher Education Commission, Prince George's Community College (PGCC) in Maryland conducted a study of the status of first-time, full-time students at PGCC 4 years after entry. In particular, the study examined the number and percentages of students earning certificates and associate degrees and/or…

  12. Obesity and Developmental Functioning among Children Aged 2-4 Years. National Poverty Center Working Paper Series #08-07

    ERIC Educational Resources Information Center

    Cawley, John; Spiess, C. Katharina

    2008-01-01

    In developed countries, obesity tends to be associated with worse labor market outcomes. One possible reason is that obesity leads to less human capital formation early in life. This paper investigates the association between obesity and the developmental functioning of children at younger ages (2-4 years) than ever previously examined. Data from…

  13. Barriers and Opportunities for 2-Year and 4-Year STEM Degrees: Systemic Change to Support Students' Diverse Pathways

    ERIC Educational Resources Information Center

    Malcom, Shirley, Ed.; Feder, Michael, Ed.

    2016-01-01

    Nearly 40 percent of the students entering 2- and 4-year postsecondary institutions indicated their intention to major in science, technology, engineering, and mathematics (STEM) in 2012. But the barriers to students realizing their ambitions are reflected in the fact that about half of those with the intention to earn a STEM bachelor's degree and…

  14. Higher education for refugees: Lessons from a 4-year pilot project

    NASA Astrophysics Data System (ADS)

    Crea, Thomas M.; McFarland, Mary

    2015-04-01

    Refugees experience limited access to adequate education at all levels, but opportunities for higher education are especially lacking. Yet, evidence suggests that education plays an important protective role in helping refugee individuals and communities cope with their daily existence during protracted waiting periods, and the United Nations refugee agency (UNHCR) recently recognised tertiary education as a basic human right. The purpose of this paper is to present findings from the evaluation of a pilot programme, Jesuit Commons: Higher Education at the Margins (JC:HEM), which initially provided higher education to refugees in Kakuma Camp, Kenya and Dzaleka Camp, Malawi; and to urban refugees in Amman, Jordan. The authors of this note review the progress made towards the pilot objectives, as well as student feedback on the benefits and challenges of higher education for refugees and others living at the margins. The refugees interviewed in this study expressed feelings of empowerment, related to their expanded worldview as well as to a specific set of skills obtained through their participation in the programme. Interviewees also noted a number of limitations specific to the context of their living conditions. Particularly in refugee camps, students expressed concerns about what would happen after their having completed their course. The general outcome of the pilot phase, which ended in 2014, was that the programme addresses a critical need and that it should be continued, albeit with key modifications in its design and delivery. Key areas for future growth of the programme include curriculum transformation, integrated service delivery and university engagement.

  15. Phobic anxiety and cognitive performance over 4 years among community-dwelling older women in the Nurses’ Health Study

    PubMed Central

    Okereke, Olivia I.; Grodstein, Francine

    2012-01-01

    Objective To examine the relation of phobic anxiety to late-life cognitive trajectory. Design Prospective cohort. Setting Nurses’ Health Study – U.S. registered nurses. Participants 16,351 women among whom phobic anxiety symptoms were assessed in 1988 (mean age=63 years). Measurements Beginning a decade after phobic anxiety ascertainment (mean age=74 years), three assessments of general cognition, word and paragraph immediate and delayed recall, category fluency, and attention/working memory were administered over an average of 4.4 years; global cognitive and verbal memory composite scores were generated from the component tests. General linear models of response profiles were used to evaluate relations of phobic anxiety to initial cognitive performance and subsequent change. Results Higher phobic anxiety was associated with poorer initial performance: e.g., comparing women with the highest anxiety to those with no/minimal symptoms, the multivariate-adjusted mean difference (95% confidence interval) in scores was −0.10 (−0.13,−0.06) standard units for the global score summarizing all tests, and −0.08 (−0.11,−0.04) standard units for verbal memory (summarizing 4 word- and paragraph-recall tasks). Mean differences between extreme categories of phobic anxiety were equal to those for participants aged 1.5–2 years apart: i.e., cognitively equivalent to being about two years older. There were no relations of phobic anxiety to subsequent cognitive change. Conclusions Higher mid-life phobic anxiety was related to worse later-life overall cognition and verbal memory. Yet, profiles of poorer cognition with higher anxiety remained parallel over time, suggesting phobic anxiety may impose impact on cognition earlier in life, rather than ongoing impact in later-life. PMID:23567369

  16. National pathfinder survey on children's oral health in Italy: pattern and severity of caries disease in 4-year-olds.

    PubMed

    Campus, G; Solinas, G; Strohmenger, L; Cagetti, M G; Senna, A; Minelli, L; Majori, S; Montagna, M T; Reali, D; Castiglia, P

    2009-01-01

    This paper describes the dental health status of Italian 4-year-olds in 2004/2005 and analyzes the association between caries in preschool children and some background characteristics in children and parents. Caries was recorded according to WHO criteria. 5,538 subjects were examined. Information on the children's and their parents' social, behavioral, ethnic and demographic status was obtained through a series of closed questions. Bivariate analysis was performed to investigate the association between caries and background characteristics. The probability of being an extra zero for the dmfs index was estimated via the zero-inflated negative binomial regression model (ZINB). 78.4% (95% CI = 77.2-79.6) of the children were caries-free. The national mean dmfs index was 1.36 (95% CI = 1.15-1.57), ranging from 1.22 (95% CI = 1.03-1.42) in the Italian North-East to 1.73 (95% CI = 0.83-2.63) in the South section. Significant bivariate associations between caries experience and risk factors were observed for parents' nationality (not Italian vs. Italian: p < 0.001), parents' educational levels (low vs. high: p < 0.001), preterm birth (yes vs. no: p = 0.011), prolonged breastfeeding (13 months: p = 0.038) and early tooth eruption (<6 months as reference: p = 0.004). Multivariable analysis (ZINB) showed that children with a low caries risk level had a higher probability of being an extra zero; in particular, children from fathers with a high educational level showed a probability of being an extra zero of 0.22. The results suggest a need to plan preventive programs to reduce oral health disparities among Italian preschool children, based on educational intervention with parents and children concerning oral health and caries prevention. PMID:19365120

  17. Fat Imaging via Magnetic Resonance Imaging (MRI) in Young Children (Ages 1-4 Years) without Sedation

    PubMed Central

    Shearrer, Grace E.; House, Benjamin T.; Gallas, Michelle C.; Luci, Jeffrey J.; Davis, Jaimie N.

    2016-01-01

    Introduction This pilot study developed techniques to perform Magnetic Resonance Imaging (MRI) of specific fat deposition in 18 children (age 18 months to 4 years). Methods The children engaged in a series of practice tests to become acclimated to the scanner noises, reduce claustrophobia, and rehearse holding still for a set time. The practice tests assessed if the child could remain still for two minutes while watching a video, first while lying on a blanket, second, on the blanket with headphones, and third, in the mock scanner. The children who passed the three practice tests were then scanned with a 3T Siemens Skyra magnet. Abdominal fat distribution (region of interest (ROI) from the top of the ileac crest to the bottom of the ribcage) volume was measured using 2-point DIXON technique. This region was chosen to give an indication of the body composition around the liver. Results Twelve out of eighteen participants successfully completed the actual MRI scan. Chi-squared test showed no significant difference between male and female pass-fail rates. The median age of completed scans was 36 months, whereas the median age for children unable to complete a scan was 28 months. The average total trunk fat was 240.9±85.2mL and the average total VAT was 37.7±25.9mLand liver fat was not quantifiable due to physiological motion. Several strategies (modeling, videos, and incentives) were identified to improve pediatric imaging in different age ranges. Conclusion Using an age-specific and tailored protocol, we were able to successfully use MRI for fat imaging in a majority of young children. Development of such protocols enables researchers to better understand the etiology of fat deposition in young children, which can be used to aid in the prevention and treatment of adiposity. PMID:26901881

  18. Identification of an obese eating style in 4-year-old children born at high and low risk for obesity.

    PubMed

    Berkowitz, Robert I; Moore, Renee' H; Faith, Myles S; Stallings, Virginia A; Kral, Tanja V E; Stunkard, Albert J

    2010-03-01

    This study tested whether children's eating behavior and parental feeding prompts during a laboratory test meal differ among children born at high risk (HR) or low risk (LR) for obesity and are associated with excess child weight gain. At 4 years of age, 32 HR children (mean maternal prepregnancy BMI = 30.4 kg/m(2)) and 29 LR children (maternal BMI = 19.6 kg/m(2)) consumed a test meal in which their eating behavior was assessed, including rate of caloric consumption, mouthfuls/min, and requests for food. Parental prompts for the child to eat also were measured at year 4, and child body composition was measured at ages 4 and 6 years. T-tests, and logistic and multiple regression analyses tested study aims. Results indicated that HR and LR children did not differ in eating rate or parental feeding prompts. Greater maternal BMI, child mouthfuls of food/min, and total caloric intake/min during the test meal predicted an increased risk of being overweight or obese at age 6, whereas greater active mealtime was associated with a reduced risk of being overweight or obese. Regression analyses indicated that only mouthfuls of food/min predicted changes in BMI from 4 to 6 years, and mouthfuls of food/min and gender predicted 2-year changes in sum of skinfolds and total body fat. Thus, a rapid eating style, characterized by increased mouthfuls of food/min, may be a behavioral marker for the development of childhood obesity. PMID:19779474

  19. Injury risk is low among world-class volleyball players: 4-year data from the FIVB Injury Surveillance System

    PubMed Central

    Bere, Tone; Kruczynski, Jacek; Veintimilla, Nadège; Hamu, Yuichiro; Bahr, Roald

    2015-01-01

    Background Little is known about the rate and pattern of injuries in international volleyball competition. Objective To describe the risk and pattern of injuries among world-class players based on data from the The International Volleyball Federation (FIVB) Injury Surveillance System (ISS) (junior and senior, male and female). Methods The FIVB ISS is based on prospective registration of injuries by team medical staff during all major FIVB tournaments (World Championships, World Cup, World Grand Prix, World League, Olympic Games). This paper is based on 4-year data (September 2010 to November 2014) obtained through the FIVB ISS during 32 major FIVB events (23 senior and 9 junior). Results The incidence of time-loss injuries during match play was 3.8/1000 player hours (95% CI 3.0 to 4.5); this was greater for senior players than for junior players (relative risk: 2.04, 1.29 to 3.21), while there was no difference between males and females (1.04, 0.70 to 1.55). Across all age and sex groups, the ankle was the most commonly injured body part (25.9%), followed by the knee (15.2%), fingers/thumb (10.7%) and lower back (8.9%). Injury incidence was greater for centre players and lower for liberos than for other player functions; injury patterns also differed between player functions. Conclusions Volleyball is a very safe sport, even at the highest levels of play. Preventive measures should focus on acute ankle and finger sprains, and overuse injuries in the knee, lower back and shoulder. PMID:26194501

  20. Organic micro-pollutants in a karst system during low and high flow periods, results of a two-year study

    NASA Astrophysics Data System (ADS)

    Reh, Roland; Licha, Tobias; Geyer, Tobias; Nödler, Karsten; Sauter, Martin

    2013-04-01

    and desethylatrazine, indicates limited aquifer connections and demonstrates a residence time of several years for vertical transport into the deep aquifer. Phenazone originates also from a disused waste disposal and is showing a persistency for more than three decades under the observed redox conditions. References Nödler K, Licha T, Bester K, Sauter M. Development of a multi-residue analytical method, based on liquid chromatography-tandem mass spectrometry, for the simultaneous determination of 46 micro-contaminants in aqueous samples. Journal of Chromatography A 2010;1217(42), 6511-6521. Reh R, Licha T, Geyer T, Nödler, K.,Sauter M. Occurrence and spatial distribution of organic micro-pollutants in a complex hydrogeological karst system during low flow and high flow periods, results of a two-year study. Science of The Total Environment 2013, 443,438-445, 10.1016/j.scitotenv.2012.11.005.

  1. Fathers' challenging parenting behavior prevents social anxiety development in their 4-year-old children: a longitudinal observational study.

    PubMed

    Majdandžić, Mirjana; Möller, Eline L; de Vente, Wieke; Bögels, Susan M; van den Boom, Dymphna C

    2014-02-01

    Recent models on parenting propose different roles for fathers and mothers in the development of child anxiety. Specifically, it is suggested that fathers' challenging parenting behavior, in which the child is playfully encouraged to push her limits, buffers against child anxiety. In this longitudinal study, we explored whether the effect of challenging parenting on children's social anxiety differed between fathers and mothers. Fathers and mothers from 94 families were separately observed with their two children (44 % girls), aged 2 and 4 years at Time 1, in three structured situations involving one puzzle task and two games. Overinvolved and challenging parenting behavior were coded. Child social anxiety was measured by observing the child's response to a stranger at Time 1, and half a year later at Time 2, and by parental ratings. In line with predictions, father's challenging parenting behavior predicted less subsequent observed social anxiety of the 4-year-old child. Mothers' challenging behavior, however, predicted more observed social anxiety of the 4-year-old. Parents' overinvolvement at Time 1 did not predict change in observed social anxiety of the 4-year-old child. For the 2-year-old child, maternal and paternal parenting behavior did not predict subsequent social anxiety, but early social anxiety marginally did. Parent-rated social anxiety was predicted by previous parental ratings of social anxiety, and not by parenting behavior. Challenging parenting behavior appears to have favorable effects on observed 4-year-old's social anxiety when displayed by the father. Challenging parenting behavior emerges as an important focus for future research and interventions. PMID:23812638

  2. [Effect of the type of diabetes on the prognosis over 4 years of arterial blood pressure].

    PubMed

    Mayaudon, H; Dupuy, O; Belmejdoub, G; Bredin, C; Rivetta, F; Avaro, J F; Bauduceau, B

    2000-08-01

    The aim of this study was to analyse over a four years period the blood pressure rise according to the type of diabetes. The study population was composed of 79 diabetic patients (type 1: 36; type 2: 43). An evaluation of diabetes mellitus is undertaken at a four years interval (A0, A4). In the same time, blood pressure level is assessed using clinic BP and 24 h-ambulatory blood pressure monitoring (ABPM). Type 2 diabetic patients were older than type 1 (60.9 +/- 9.5 vs 43.5 +/- 12.5 years, p < 0.001). The two groups did not differ in body mass index, tobacco consumption, diabetes duration, glycemic control and serum creatinine. Hypertension was more frequent in type 2 diabetes (46.5 vs 11.1%, p < 0.01) and baseline systolic but not diastolic casual BP was significantly higher in type 2 diabetes compared with type 1 (142 +/- 14 vs 132 +/- 15 mmHg, p < 0.01). Between A0 and A4 the increase in type 1 and type 2 diabetics casual BP was not significant. Type 1 diabetic patients 24 h-ABPM did not differ from significant manner at A0 and at A4. Type 2 diabetic subjects had an increase in 24 h and night time SBP (24 h: 123 +/- 14 at A0 vs 130 +/- 16 mmHg at A4, p < 0.05; night time: 116 +/- 15 at A0 vs 125 +/- 17 mmHg at A4, p < 0.02). This reduction in nocturnal BP fall was not associated with an increase in diabetes complications frequency. BP evolution seems to be closely linked to the type of diabetes and to patients age. In this study, frequency of diabetes complications does not increase when BP level is lower than references values for ABPM. PMID:10989751

  3. Gamma-knife radiosurgery in acromegaly: a 4-year follow-up study.

    PubMed

    Attanasio, Roberto; Epaminonda, Paolo; Motti, Enrico; Giugni, Enrico; Ventrella, Laura; Cozzi, Renato; Farabola, Mario; Loli, Paola; Beck-Peccoz, Paolo; Arosio, Maura

    2003-07-01

    , who already had partial hypopituitarism, after 2 and 6 yr, respectively. No patient developed visual deficits. GK is a valid adjunctive tool in the management of acromegaly that controls GH/IGF-I hypersecretion and tumor growth, with shrinkage of adenoma and no recurrence of the disease in the considered observation period and with low acute and chronic toxicity. PMID:12843150

  4. Evolution of periodicity in periodical cicadas

    PubMed Central

    Ito, Hiromu; Kakishima, Satoshi; Uehara, Takashi; Morita, Satoru; Koyama, Takuya; Sota, Teiji; Cooley, John R.; Yoshimura, Jin

    2015-01-01

    Periodical cicadas (Magicicada spp.) in the USA are famous for their unique prime-numbered life cycles of 13 and 17 years and their nearly perfectly synchronized mass emergences. Because almost all known species of cicada are non-periodical, periodicity is assumed to be a derived state. A leading hypothesis for the evolution of periodicity in Magicicada implicates the decline in average temperature during glacial periods. During the evolution of periodicity, the determinant of maturation in ancestral cicadas is hypothesized to have switched from size dependence to time (period) dependence. The selection for the prime-numbered cycles should have taken place only after the fixation of periodicity. Here, we build an individual-based model of cicadas under conditions of climatic cooling to explore the fixation of periodicity. In our model, under cold environments, extremely long juvenile stages lead to extremely low adult densities, limiting mating opportunities and favouring the evolution of synchronized emergence. Our results indicate that these changes, which were triggered by glacial cooling, could have led to the fixation of periodicity in the non-periodical ancestors. PMID:26365061

  5. Sex-specific trends in 4-year survival in 37 276 men and women with acute myocardial infarction before the age of 55 years in Sweden, 1987–2006: a register-based cohort study

    PubMed Central

    Nielsen, S; Björck, L; Berg, J; Giang, K W; Zverkova Sandström, T; Falk, K; Määttä, S; Rosengren, A

    2014-01-01

    Objective To examine sex-specific trends in 4-year mortality among young patients with first acute myocardial infarction (AMI), 1987–2006. Design Prospective cohort study. Setting Sweden. Participants We identified 37 276 cases (19.4% women; age, 25–54 years) from the Swedish Inpatient Register, 1987–2006, who had survived 28 days after an AMI. Outcome measures 4-year mortality from all causes and standard mortality ratio (SMR). Results From the first to last 5-year period, the absolute excess risk decreased from 1.38 to 0.50 and 1.53 to 0.59 per 100 person-years among men aged 25–44 and 45–54 years, respectively. Corresponding figures for women were a decrease from 2.26 to 1.17 and from 1.93 to 1.45 per 100 person-years, respectively. Trends for women were non-linear, decreasing to the same extent as those for men until the third period, then increasing. For the last 5-year period, the standardised mortality ratio for young survivors of AMI compared with the general population was 4.34 (95% CI 3.04 to 5.87) and 2.43 (95% CI 2.12 to 2.76) for men aged 25–44 and 45–54 years, respectively, and 13.53 (95% CI 8.36 to 19.93) and 6.42 (95% CI 5.24 to 7.73) for women, respectively. Deaths not associated with cardiovascular causes increased from 21.5% to 44.6% in men and 41.5% to 65.9% in women. Conclusions Young male survivors of AMI have low absolute long-term mortality rates, but these rates remain twofold to fourfold that of the general population. After favourable development until 2001, women now have higher absolute mortality than men and a 6-fold to 14-fold risk of death compared with women in the general population. PMID:24793251

  6. The Research-Based Model Partnership Education Program: A 4-Year Outcome Study.

    ERIC Educational Resources Information Center

    Tucker, Carolyn M.; Herman, Keith C.; Reid, Alaycia D.; Keefer, Nikki L.; Vogel, David L.

    1998-01-01

    Evaluated the four-year outcome of the Research-Based Model Partnership in Education Program, an after-school tutoring and adaptive-skills training program for mostly low-achieving, low-income African-American students. Computerized school records provided academic and social data. Results indicated that four-year participants had higher grade…

  7. Safety and Tolerability of Atomoxetine over 3 to 4 Years in Children with ADHD

    ERIC Educational Resources Information Center

    Donnelly, Craig; Bangs, Mark; Trzepacz, Paula; Jin, Ling; Zhang, Shuyu; Witte, Michael M.; Ball, Susan G.; Spencer, Thomas J.

    2009-01-01

    Data from 13 double-blind, placebo-controlled trials and three open-label extension studies were pooled to examine the safety of atomoxetine for treating attention deficit hyperactivity disorder in children and adolescents for less than or equal to three or four years. Results show that atomoxetine is safe and well tolerated in the subjects.

  8. [4 years' evaluation of orthopedics and traumatology at an African Regional Hospital].

    PubMed

    Ribault, L; Gournier, J P

    1989-01-01

    The authors have made an evaluation of the results obtained in orthopaedic surgery and traumatology after a four year practice at the Korhogo hospital (Cote d'Ivoire). They analyse the peculiar conditions bond to the pathology, climate, environment, technical level. The incidence of post operative sepsis was 2.8 per cent, comparable to european statistics. Bed sores were exceptional, the general rate of nonunions was 2.9 per cent. The functional results were hardly analysable. However they seemed to be rather satisfactory despite the lack of post operative rehabilitation. It is concluded that an orthopaedic and traumatologic practice can be valuably conducted in Africa even far from the main centers, provided a rigorous organisation. PMID:2552513

  9. Measuring, discussing, and living together: lessons from 4 years in Suetsugi.

    PubMed

    Ando, R

    2016-06-01

    Cooperating with radiological protection experts and taking radiation measurements, the residents of Suetsugi, Iwaki City, Fukushima have been striving to reshape their lives since the accident at Fukushima Daiichi nuclear power plant. Suetsugi lies within 30 km of the power plant, so the residents have had serious reservations about continuing their lives there since the accident. Today, radiation remains a 'line' dividing their lives, with any dose measurements directly affecting their daily decision making. Assisted by medical and scientific specialists, the residents faced this challenging situation by measuring exposures individually and then discussing the results among themselves. Since 2012, the residents of Suetsugi have been using personal dosimeters, made village-wide trips for whole-body counter tests, and measured food contamination throughout the village. The results have been shared openly between the residents. Obtaining and discussing their own data were crucial to gain understanding of various results and to practice radiological protection in their daily routine. These 4 y of experience in Suetsugi demonstrate cooperation between various stakeholders, which should be a lesson for the future. PMID:26626285

  10. Identification of mucorales from clinical specimens: a 4-year experience in a single institution.

    PubMed

    Yang, Mina; Lee, Jang Ho; Kim, Young Kwon; Ki, Chang Seok; Huh, Hee Jae; Lee, Nam Yong

    2016-01-01

    Mucormycosis, a fatal opportunistic infection in immunocompromised hosts, is caused by fungi belonging to the order Mucorales. Early diagnosis based on exact identification and multidisciplinary treatments is critical. However, identification of Mucorales fungi is difficult and often delayed, resulting in poor prognosis. This study aimed to compare the results of phenotypic and molecular identification of 12 Mucorales isolates collected from 4-yr-accumulated data. All isolates were identified on the basis of phenotypic characteristics such as growth rate, colony morphology, and reproductive structures. PCR and direct sequencing were performed to target internal transcribed spacer (ITS) and/or D1/D2 regions. Target DNA sequencing identified five Lichtheimia isolates, two Rhizopus microsporus isolates, two Rhizomucor pusillus isolates, one Cunninghamella bertholletiae isolate, one Mucor fragilis isolate, and one Syncephalastrum racemosum isolate. Five of the 12 (41.7%) isolates were incorrectly identified on the basis of phenotypic identification. DNA sequencing showed that of these five isolates, two were Lichtheimia isolates, one was Mucor isolate, one was Rhizomucor isolate, and one was Rhizopus microspores. All the isolates were identified at the species level by ITS and/or D1/D2 analyses. Phenotypic differentiation and identification of Mucorales is difficult because different Mucorales share similar morphology. Our results indicate that the molecular methods employed in this study are valuable for identifying Mucorales. PMID:26522761

  11. The Winning with Wellness pilot project: rural Appalachian elementary student physical activity and eating behaviors and program implementation 4 years later.

    PubMed

    Schetzina, Karen E; Dalton, William T; Pfortmiller, Deborah T; Robinson, Hazel F; Lowe, Elizabeth F; Stern, H Patrick

    2011-01-01

    School-based efforts to promote physical activity and healthier eating are a potentially effective approach to decreasing child obesity in rural populations. This article describes follow-up data on student activity and eating behaviors 4 years after implementation of the Winning with Wellness obesity prevention initiative. This project was based on the Centers for Disease Control and Prevention's coordinated school health model and used a community-based participatory research approach to address health behaviors in rural Appalachian elementary students. Results suggest significant increases in daily pedometer steps and healthier food selections by students as well as teacher support for continued health promotion efforts. PMID:21378512

  12. Nutrient emissions from diffuse and point sources into the River Danube and its main tributaries for the period of 1998-2000--results and problems.

    PubMed

    Schreiber, H; Behrendt, H; Constantinescu, L T; Cvitanic, I; Drumea, D; Jabucar, D; Juran, S; Pataki, B; Snishko, S; Zessner, M

    2005-01-01

    Nutrient emissions by point and diffuse sources were estimated for 388 sub-catchments of the Danube river basin for the period 1998-2000 by means of the Model MONERIS. For nitrogen total emissions of 684 kt/a N were estimated for the Danube basin. 80% of these emissions were caused by diffuse sources (mainly groundwater, urban areas and tile drainage). For phosphorus the emission was 57 kt/a P, with a contribution of diffuse sources to this sum of 58%. The comparison of calculated and observed loads shows that the mean deviation for the investigated sub-catchments of the Danube river basin is 20% for dissolved inorganic nitrogen and 34% for phosphorus. The spatial resolution of the emission calculations allows the identification of regional hot spots and the derivation of specific regional measures to reduce the emissions into the Danube and consequently into the Western Black Sea. PMID:15850201

  13. Evaluation of 4 years of continuous δ13C(CO2) data using a moving Keeling plot method

    NASA Astrophysics Data System (ADS)

    Vardag, Sanam Noreen; Hammer, Samuel; Levin, Ingeborg

    2016-07-01

    Different carbon dioxide (CO2) emitters can be distinguished by their carbon isotope ratios. Therefore measurements of atmospheric δ13C(CO2) and CO2 concentration contain information on the CO2 source mix in the catchment area of an atmospheric measurement site. This information may be illustratively presented as the mean isotopic source signature. Recently an increasing number of continuous measurements of δ13C(CO2) and CO2 have become available, opening the door to the quantification of CO2 shares from different sources at high temporal resolution. Here, we present a method to compute the CO2 source signature (δS) continuously and evaluate our result using model data from the Stochastic Time-Inverted Lagrangian Transport model. Only when we restrict the analysis to situations which fulfill the basic assumptions of the Keeling plot method does our approach provide correct results with minimal biases in δS. On average, this bias is 0.2 ‰ with an interquartile range of about 1.2 ‰ for hourly model data. As a consequence of applying the required strict filter criteria, 85 % of the data points - mainly daytime values - need to be discarded. Applying the method to a 4-year dataset of CO2 and δ13C(CO2) measured in Heidelberg, Germany, yields a distinct seasonal cycle of δS. Disentangling this seasonal source signature into shares of source components is, however, only possible if the isotopic end members of these sources - i.e., the biosphere, δbio, and the fuel mix, δF - are known. From the mean source signature record in 2012, δbio could be reliably estimated only for summer to (-25.0 ± 1.0) ‰ and δF only for winter to (-32.5 ± 2.5) ‰. As the isotopic end members δbio and δF were shown to change over the season, no year-round estimation of the fossil fuel or biosphere share is possible from the measured mean source signature record without additional information from emission inventories or other tracer measurements.

  14. Implementation of a Zebrafish Health Program in a Research Facility: A 4-Year Retrospective Study.

    PubMed

    Borges, Ana C; Pereira, Nuno; Franco, Maysa; Vale, Liliana; Pereira, Margarida; Cunha, Mónica V; Amaro, Ana; Albuquerque, Teresa; Rebelo, Manuel

    2016-07-01

    In the past two decades, zebrafish (Danio rerio)-based research has contributed to significant scientific advances. Still, husbandry and health programs did not evolve at the same pace, as evidenced by the absence of general guidelines. Health monitoring is essential to animal welfare, to permit animal exchanges across facilities, to contribute to robust experimental results, and for data reproducibility. In this study, we report a health program implemented in a zebrafish research facility to prevent, monitor, and control pathogen, and disease dissemination. This program includes quarantine, routine health screening of sentinels, and nonroutine screenings of retired animals and sick/moribund individuals. An extensive list of clinical signs, lesions, and pathogens was monitored based on: daily observation of fish, necropsy, histology, and bacterial culture. The results indicate that the combined analysis of sentinels with the evaluation of sick/moribund animals enables a comprehensive description not only of pathogen prevalence but also of clinical and histopathologic lesions of resident animals. The establishment of a quarantine program revealed to be effective in the reduction of Pseudoloma neurophilia frequency in the main aquaria room. Finally, characterization of the colony health status based on this multiapproach program shows a low prevalence of lesions and pathogens in the facility. PMID:27186875

  15. Implementation of a Zebrafish Health Program in a Research Facility: A 4-Year Retrospective Study

    PubMed Central

    Pereira, Nuno; Franco, Maysa; Vale, Liliana; Pereira, Margarida; Cunha, Mónica V.; Amaro, Ana; Albuquerque, Teresa; Rebelo, Manuel

    2016-01-01

    Abstract In the past two decades, zebrafish (Danio rerio)-based research has contributed to significant scientific advances. Still, husbandry and health programs did not evolve at the same pace, as evidenced by the absence of general guidelines. Health monitoring is essential to animal welfare, to permit animal exchanges across facilities, to contribute to robust experimental results, and for data reproducibility. In this study, we report a health program implemented in a zebrafish research facility to prevent, monitor, and control pathogen, and disease dissemination. This program includes quarantine, routine health screening of sentinels, and nonroutine screenings of retired animals and sick/moribund individuals. An extensive list of clinical signs, lesions, and pathogens was monitored based on: daily observation of fish, necropsy, histology, and bacterial culture. The results indicate that the combined analysis of sentinels with the evaluation of sick/moribund animals enables a comprehensive description not only of pathogen prevalence but also of clinical and histopathologic lesions of resident animals. The establishment of a quarantine program revealed to be effective in the reduction of Pseudoloma neurophilia frequency in the main aquaria room. Finally, characterization of the colony health status based on this multiapproach program shows a low prevalence of lesions and pathogens in the facility. PMID:27186875

  16. Analysis of the 4-year IceCube high-energy starting events

    NASA Astrophysics Data System (ADS)

    Vincent, Aaron C.; Palomares-Ruiz, Sergio; Mena, Olga

    2016-07-01

    After four years of data taking, the IceCube neutrino telescope has detected 54 high-energy starting events (HESE, or contained-vertex events) with deposited energies above 20 TeV. They represent the first detection of high-energy extraterrestrial neutrinos and, therefore, the first step in neutrino astronomy. To study the energy, flavor, and isotropy of the astrophysical neutrino flux arriving at Earth, we perform different analyses of two different deposited energy intervals, [10 TeV-10 PeV] and [60 TeV-10 PeV]. We first consider an isotropic unbroken power-law spectrum and constrain its shape, normalization, and flavor composition. Our results are in agreement with the preliminary IceCube results, although we obtain a slightly softer spectrum. We also find that current data are not sensitive to a possible neutrino-antineutrino asymmetry in the astrophysical flux. Then, we show that although a two-component power-law model leads to a slightly better fit, it does not represent a significant improvement with respect to a single power-law flux. Finally, we analyze the possible existence of a north-south asymmetry, hinted at by the combination of the HESE sample with the throughgoing muon data. If we use only HESE data, the scarce statistics from the Northern Hemisphere does not allow us to reach any conclusive answer, which indicates that the HESE sample alone is not driving the potential north-south asymmetry.

  17. Zirconia Implants in Esthetic Areas: 4-Year Follow-Up Evaluation Study

    PubMed Central

    Borgonovo, Andrea Enrico; Censi, Rachele; Vavassori, Virna; Arnaboldi, Oscar; Maiorana, Carlo

    2015-01-01

    Objectives. The aim is to evaluate the survival and success rates, as well as the marginal bone loss (MBL) and periodontal indexes of zirconia implants positioned in the esthetic jaw areas. Materials and Method. 13 patients were selected and 20 one-piece zirconia implants were used for the rehabilitation of single tooth or partially edentulous ridge in the esthetic jaw areas. Six months after surgery and then once a year, a clinical-radiographic evaluation was performed in order to estimate peri-implant tissue health and marginal bone loss. Results. The survival and success rates were 100%. The average marginal bone loss from baseline to 48 months after surgery was +2.1 mm. Four years after surgery, the median and the mode for visible Plaque Index and Bleeding On Probing resulted 1 whereas Probing Pocket Depth amounted to 3 mm (SD = ±0.49 mm). Conclusion. One-piece zirconia dental implants are characterized by high biocompatibility, low plaque adhesion, and absence of microgap that can be related to the clinical success of these implants even in the esthetic areas. PMID:26124836

  18. Public Health Impact After the Introduction of PsA-TT: The First 4 Years

    PubMed Central

    Diomandé, Fabien V. K.; Djingarey, Mamoudou H.; Daugla, Doumagoum M.; Novak, Ryan T.; Kristiansen, Paul A.; Collard, Jean-Marc; Gamougam, Kadidja; Kandolo, Denis; Mbakuliyemo, Nehemie; Mayer, Leonard; Stuart, James; Clark, Thomas; Tevi-Benissan, Carol; Perea, William A.; Preziosi, Marie-Pierre; Marc LaForce, F.; Caugant, Dominique; Messonnier, Nancy; Walker, Oladapo; Greenwood, Brian

    2015-01-01

    Background. During the first introduction of a group A meningococcal vaccine (PsA-TT) in 2010–2011 and its rollout from 2011 to 2013, >150 million eligible people, representing 12 hyperendemic meningitis countries, have been vaccinated. Methods. The new vaccine effectiveness evaluation framework was established by the World Health Organization and partners. Meningitis case-based surveillance was strengthened in PsA-TT first-introducer countries, and several evaluation studies were conducted to estimate the vaccination coverage and to measure the impact of vaccine introduction on meningococcal carriage and disease incidence. Results. PsA-TT implementation achieved high vaccination coverage, and results from studies conducted showed significant decrease of disease incidence as well as significant reduction of oropharyngeal carriage of group A meningococci in vaccinated and unvaccinated individuals, demonstrating the vaccine's ability to generate herd protection and prevent group A epidemics. Conclusions. Lessons learned from this experience provide useful insights in how to guide and better prepare for future new vaccine introductions in resource-limited settings. PMID:26553676

  19. Height, infant-feeding practices and cardiovascular functioning among 3 or 4 year old children in three ethnic groups.

    PubMed

    Baranowski, T; Bryan, G T; Harrison, J A; Rassin, D K; Greaves, K A; Baranowski, J H

    1992-05-01

    Barker recently hypothesized that factors affecting prenatal and infant growth are related to adult blood pressure and CVD mortality. Predictions from Barker's hypothesis in regard to infant feeding were tested among a sample of 3 or 4 year old children. The relationship of infant-feeding characteristics (duration of breast-feeding, times of introduction of high fat, high carbohydrate, high potassium foods and table salt) to indicators of cardiovascular functioning (resting blood pressures and heart rates, and heart rate response to graded activity) while controlling for anthropometric (height, sum of seven skinfolds, BMI) and demographic (ethnicity, gender, social status) characteristics revealed that infant-feeding practices were not related to CV functioning in the predicted directions among this sample of 3 or 4 year old children. Furthermore, the positive relationship between height and systolic blood pressure was inconsistent with the Barker hypothesis. PMID:1588357

  20. Evidence of deontic reasoning in 3- and 4-year-old children.

    PubMed

    Cummins, D D

    1996-11-01

    Deontic reasoning is reasoning about what one may, ought, or ought not do in a given set of circumstances. Virtually all of our social institutions and child-rearing practices presume the capacity to reason about deontic concepts, such as what is permitted, obligated, or prohibited. Despite this, very little is known about the development of deontic reasoning. Two experiments were conducted that contrasted children's reasoning performance on deontic and indicative reasoning tasks (i.e., the reduced array selection version of the Wason card selection task). Like adults, children as young as 3 years of age were found to adopt a violation-detecting strategy more often when reasoning about the deontic case than when reasoning about the indicative case. These results indicate that violation detection emerges as an effective deontic reasoning very early in human development. PMID:8961825

  1. Peripheral cemento-ossifying fibroma in child. A follow-up of 4 years. Report of a case.

    PubMed

    Delbem, Alberto Carlos Botazzo; Cunha, Robson Frederico; Silva, Janaína Zavitoski; Soubhia, Ana Maria Pires

    2008-04-01

    Peripheral cement-ossifying fibroma is a relatively common gingival growth of a reactive rather than neoplastic nature, whose pathogenesis is uncertain. It predominantly affects adolescents and young adults, with peak prevalence between 10 and 19 years. We report here the clinical case of a 5-year-old girl with disease duration of 3 years, who was followed up for 4 years, showing a gingival health and normal radiopacity of bone. PMID:19212524

  2. Risk of Developmental Delay Increases Exponentially as Gestational Age of Preterm Infants Decreases: A Cohort Study at Age 4 Years

    ERIC Educational Resources Information Center

    Kerstjens, Jorien M.; de Winter, Andrea F.; Bocca-TJeertes, Inger F.; Bos, Arend F.; Reijneveld, Sijmen A.

    2012-01-01

    Aim: The aim of the study was to assess the influence of decreasing gestational age on the risk of developmental delay in various domains at age 4 years among children born at a wide range of gestational ages. Method: In a community-based cohort, the parents of 1439 preterm-born children (24 0/7 to 35 6/7wks) and 544 term-born children (38 0/7 to…

  3. [Severe bacterial infections and sudden death in children less than 4-years-old: 3 case reports].

    PubMed

    Chapelon, E; Bélien-Pallet, V; Ayachi, A; Rambaud, C; Gaudelus, J; de Pontual, L

    2012-02-01

    Infectious factors contribute to sudden infant death in about 1 case out of 3. We report 3 children less than 4-years-old who died suddenly of bacterial infection due to Neisseria meningitidis, Streptococcus pneumoniae, and Staphylococcus aureus. The bacteria were isolated from central and peripheral samples. A bacterial origin should be sought in all cases of sudden death in children. When a bacterial origin is confirmed, the question of immunodeficiency should be raised. PMID:22209380

  4. Periodized wavelets

    SciTech Connect

    Schlossnagle, G.; Restrepo, J.M.; Leaf, G.K.

    1993-12-01

    The properties of periodized Daubechies wavelets on [0,1] are detailed and contrasted against their counterparts which form a basis for L{sup 2}(R). Numerical examples illustrate the analytical estimates for convergence and demonstrate by comparison with Fourier spectral methods the superiority of wavelet projection methods for approximations. The analytical solution to inner products of periodized wavelets and their derivatives, which are known as connection coefficients, is presented, and several tabulated values are included.

  5. Dynesys dynamic stabilization: less good outcome than lumbar fusion at 4-year follow-up.

    PubMed

    Haddad, Behrooz; Makki, Daoud; Konan, Sujith; Park, Derek; Khan, Wasim; Okafor, Ben

    2013-02-01

    Dynamic semirigid stabilization of the lumbar spine was introduced in 1994 in an attempt to overcome the drawbacks of fusion. It is supposed to preserve motion at the treated levels, while avoiding hypermobility and thus spondylosis at the adjacent levels. Although the early reports showed promising results, the long term effects are still debated. We retrospectively compared outcomes of Dynesys dynamic stabilization with those of the traditional fusion technique. Thirty-two patients who had undergone Dynesys between 2004 and 2006 (group 1) were compared to 32 patients who had been treated with fusion between 2005 and 2006 (group 2). VAS for back and leg pain, and ODI improved significantly in both groups (p < 0.001). These scores were all better in the fusion group, and even significantly so as far as VAS for back pain was concerned (p = 0.014). Similarly, more patients were satisfied or very satisfied after fusion than after Dynesys: 87.5% versus 68.8% (p = 0.04). Interestingly, in the Dynesys group scatter plot graphs showed a positive correlation between older age and improvement in the two VAS scores and in ODI. Dynamic stabilization with Dynesys remains controversial. Older patients are relatively more satisfied about it, probably because of their low level of demands. PMID:23547523

  6. Evaluation after 4 years of the combined use of fluoride and dental sealants.

    PubMed

    Selwitz, R H; Nowjack-Raymer, R; Driscoll, W S; Li, S H

    1995-02-01

    This study evaluates the caries-preventive potential in permanent teeth of dental sealants when combined with an ongoing, school-based fluoride program. The investigation was designed as a sequential, cross-sectional comparison. Dental caries findings in 1987 for 416 children ages 7-11 and 14-17 who received dental sealants and fluorides were compared with corresponding data derived from 1983 baseline examinations of children who received fluoride therapy only. In addition, sealant retention status was determined. Overall mean DMFS scores in 1987 for children in two age groups combined were 51% lower than in 1983. Also, a surface-specific treatment effect was demonstrated in pit and fissures for both older and younger age groups. The overall proportion of sealants retained on occlusal surfaces of first molars after an average of 2 yr (92%) compared favorably with similar figures cited in the scientific literature. The results of this study suggest that pit and fissure sealants confer additional caries-preventive benefits beyond those of fluoride therapy alone. PMID:7774174

  7. [Evaluation after 4 years' experience with breast implants coated with microthane].

    PubMed

    Baudelot, S

    1989-01-01

    The treatment of breast hypotrophy has for a long time been considered to be one of the most difficult problems to resolve in our specialty. Even in the best hands and even with the most reliable prostheses in terms of manufacture and origin, the major risk of a fibrous capsule still persists. A a result of this complication, the most beautiful operation is doomed to failure with sometimes severe and always unacceptable morphological and psychological implications. The development of microthane-coated prostheses appears to have radically changed the problem. The incidence of fibrous capsules has fallen, according to most statistics, to 2 to 3% which obviously bears no relation to the rates observed previously (gel: more than 50%, inflatable: 30%). We have not observed any complications inherent to the presence of microthane: difficulty of removal, increased incidence of infection. The only particular feature is possibly an increased difficulty of insertion. Although not a miracle cure, this implant appears to be remarkable and its qualities have resisted the test of time: almost ten years in the USA and four years in our personal experience. PMID:2473688

  8. Physical Activity during Pregnancy and Offspring Neurodevelopment and IQ in the First 4 Years of Life

    PubMed Central

    Domingues, Marlos R.; Matijasevich, Alicia; Barros, Aluísio J. D.; Santos, Iná S.; Horta, Bernardo L.; Hallal, Pedro C.

    2014-01-01

    Background Maternal physical activity during pregnancy could alter offspring's IQ and neurodevelopment in childhood. Methods Children belonging to a birth cohort were followed at 3, 12, 24 and 48 months of age. Physical activity during pregnancy was assessed retrospectively at birth. Neurodevelopment was evaluated by Battelle's Development Inventory (12, 24 and 48 months) and IQ by the Weschler's Intelligence Scale (48 months). Neurodevelopment was based on Battelles' (90th percentile) and also analyzed as a continuous outcome. IQ was analyzed as a continuous outcome. Potential confounders were: family income, mother's age, schooling, skin color, number of previous births and smoking; and newborns': preterm birth, sex and low birth weight. Results From birth to 48 months, sample size decreased from 4231 to 3792. Crude analysis showed that IQ at 48 months was slightly higher (5 points) among children from active women. The Battelle's score at 12 and 24 months was higher among offspring from active mothers. After controlling for confounders, physical activity during pregnancy was positively associated to the Battelle's Inventory at 12 months IQ, however, at 48 months no association was observed. Conclusion Physical activity during pregnancy does not seem to impair children's neurodevelopment and children from active mothers presented better performance at 12 months. PMID:25350666

  9. Determinants of waterpipe smoking initiation among school children in Irbid, Jordan: a 4-year longitudinal analysis*

    PubMed Central

    McKelvey, Karma; Attonito, Jennifer; Madhivanan, Purnima; Jaber, Rana; Yi, Qilong; Mzayek, Fawaz; Maziak, Wasim

    2014-01-01

    Objective Guided by the Attitude-Social influence-self Efficacy (ASE) theory, this study identified predictors of waterpipe (WP) smoking initiation in a WP naïve cohort of Jordanian schoolchildren. Methods A school-based cohort of all 7th grade students (N=1,781) in 19 of 60 schools in Irbid, Jordan, was followed from 2008 to 2011. Generalized linear mixed modeling was used to examine predictors of WP initiation among WP-naïve students (N=1,243). Results During the 3-year study, WP initiation was documented in 39% of boys and 28% of girls. Prior cigarette smoking (boys: Odds Ratio 7.41; 95% Confidence Interval 4.05–12.92 and girls: 8.48; 4.34–16.56) and low WP refusal self-efficacy (boys: 26.67; 13.80–51.53 and girls: 11.49; 6.42–20.55) were strongly predictive of initiating WP. Boys were also more likely to initiate WP smoking if they had siblings (2.30; 1.14- 4.64) or teachers (2.07; 1.12–3.84) who smoked and girls if they had friends (2.96; 1.59–5.54) who smoked. Conclusion There is a sizeable incidence of WP initiation among students of both sexes. These findings will help in designing culturally responsive prevention interventions against WP smoking. Gender-specific factors, refusal skills, and cigarette smoking need to be important components of such initiatives. PMID:25060962

  10. Summary of a 4-Year Fog Field Study in Northern Nanjing, Part 1: Fog Boundary Layer

    NASA Astrophysics Data System (ADS)

    Liu, D. Y.; Niu, S. J.; Yang, J.; Zhao, L. J.; Lü, J. J.; Lu, C. S.

    2012-05-01

    Comprehensive fog field observations were conducted during the winters of 2006-2009 at the Nanjing University of Information Science and Technology to study the macro and micro-physical structures and the physical-chemical processes of dense fogs in the area. The observations included features of the fog boundary layer, characteristics of fog water, the particle spectrum, the chemical composition of atmospheric aerosols, radiation and heat components, turbulence, meteorological elements (air temperature, pressure, wind speed, wind direction), and environmental monitoring. The fogs observed were divided into four types: radiation fog, advection-radiation fog, advection fog, and precipitation fog, according to the mechanisms and primary factors of the fog processes. Fog boundary-layer structures of different types and their corresponding characteristics were then studied. Fog boundary-layer features, temperature structures, wind fields, and fog maintenance are discussed. The results show that radiation fog had remarkable diurnal variation and formed mostly at sunset or midnight, and lifted after sunrise or at noon, and that advection-radiation fog and advection fog were of very long duration. Extremely dense fogs occurred only in radiation-related cases. Inversion in radiation fog was short-lived, disappearing 1 or 2 hours after sunrise or at noon, faster than that in advection-radiation fog. When wind direction reversed from easterly to westerly or from southerly to northerly, the fog became an extremely dense fog. Low-level jet at times impeded fog development, whereas at other times it encouraged fog continuance. The deep inversion was merely an essential condition for a thick fog layer; sufficient vapor supply was advantageous to the formation and maintenance of a deep fog layer.

  11. Frequency, causes and pattern of abdominal trauma: A 4-year descriptive analysis

    PubMed Central

    Arumugam, Suresh; Al-Hassani, Ammar; El-Menyar, Ayman; Abdelrahman, Husham; Parchani, Ashok; Peralta, Ruben; Zarour, Ahmad; Al-Thani, Hassan

    2015-01-01

    Background: The incidence of abdominal trauma is still underreported from the Arab Middle-East. We aimed to evaluate the incidence, causes, clinical presentation, and outcome of the abdominal trauma patients in a newly established trauma center. Materials and Methods: A retrospective analysis was conducted at the only level I trauma center in Qatar for the patients admitted with abdominal trauma (2008-2011). Patients demographics, mechanism of injury, pattern of organ injuries, associated extra-abdominal injuries, Injury Severity Score (ISS), Abbreviated Injury Scale, complications, length of Intensive Care Unit, and hospital stay, and mortality were reviewed. Results: A total of 6888 trauma patients were admitted to the hospital, of which 1036 (15%) had abdominal trauma. The mean age was 30.6 ± 13 years and the majority was males (93%). Road traffic accidents (61%) were the most frequent mechanism of injury followed by fall from height (25%) and fall of heavy object (7%). The mean ISS was 17.9 ± 10. Liver (36%), spleen (32%) and kidney (18%) were most common injured organs. The common associated extra-abdominal injuries included chest (35%), musculoskeletal (32%), and head injury (24%). Wound infection (3.8%), pneumonia (3%), and urinary tract infection (1.4%) were the frequently observed complications. The overall mortality was 8.3% and late mortality was observed in 2.3% cases mainly due to severe head injury and sepsis. The predictors of mortality were head injury, ISS, need for blood transfusion, and serum lactate. Conclusion: Abdominal trauma is a frequent diagnosis in multiple trauma and the presence of extra-abdominal injuries and sepsis has a significant impact on the outcome. PMID:26604524

  12. Laser-induced interstitial thermotherapy (LITT) for treatment of uterine leiomyomas: 750 myomas were treated by LITT and the results over a five-year period are analyzed

    NASA Astrophysics Data System (ADS)

    Chapman, Roxana

    1997-05-01

    Approximately 750 leiomyomas of 250 symptomatic patients were treated by LITT over a five-year period. Only 12% were lost to follow-up. Most were treated by a combination of the KTP/YAG laser, rarely by one or the other alone, and a few with the diode laser. The fiber optic was inserted 2 cm apart and, depending on the size of the tumor, 480 - 20,000 Joules were required. Most were treated laparoscopically but very large myomas were treated percutaneously under ultrasound control. Symptoms were nearly always relieved and the six failures were found to be due to unrecognized adenomyosis and other associated pathology. Half the patients complaining of infertility became pregnant and, in those whose only pathology had been leiomyomas it approached 90%. Vaginal delivery was not found to be contraindicated. Finally, oestrogen receptors and epidermal growth factor were found to be destroyed. It is concluded that LITT enables leiomyomas of all sizes and locations to be treated by a minimally invasive method with preservation of the uterus.

  13. A multicenter, open-label extension study of velaglucerase alfa in Japanese patients with Gaucher disease: Results after a cumulative treatment period of 24months.

    PubMed

    Ida, Hiroyuki; Tanaka, Akemi; Matsubayashi, Tomoko; Murayama, Kei; Hongo, Teruaki; Lee, Hak-Myung; Mellgard, Björn

    2016-07-01

    Enzyme replacement therapy (ERT) with exogenous glucocerebrosidase is indicated to treat symptomatic Gaucher disease (GD), a rare, inherited metabolic disorder. ERT with velaglucerase alfa, which is produced in a human cell line using gene activation technology, was studied in a 12-month phase III trial in Japanese patients with type 1 or 3 GD who were switched from imiglucerase ERT (n=6); the current, open-label, 12-month extension study was designed to assess longer-term safety and efficacy. Two adult and three pediatric patients (aged <18years) were enrolled into the extension study. Every-other-week intravenous infusions were administered for 63-78weeks at average doses between 51.5 and 60.7units/kg. Three non-serious adverse events were considered related to velaglucerase alfa treatment, but no patient discontinued from the study. Six serious but non-drug-related adverse events were reported. No patient tested positive for anti-velaglucerase alfa antibodies. Hemoglobin concentrations, platelet counts, and liver and spleen volumes (normalized to body weight) in these patients were generally stable over a cumulative 24-month period from the baseline of the parent trial. The data suggest that velaglucerase alfa was well tolerated and maintained clinical stability in Japanese GD patients over 2years after switching from imiglucerase. ClinicalTrials.gov identifier NCT01842841. PMID:27241455

  14. Study of the Clinical Outcome between Traumatic and Degenerative (non-traumatic) Meniscal Tears after Arthroscopic Surgery: A 4-Years Follow-up Study

    PubMed Central

    Ghislain, Nietiayurk Aminake; Wei, Ji-Nan

    2016-01-01

    Introduction The meniscus is a biconcave fibrocartilage in the knee joint interpose between the femoral condyles and tibial plateau; the meniscus has functions in load bearing, load transmission, shock absorption joint stability, joint lubrication, and joint congruity. Aim The aim of this study is to provide orthopeadic surgeon a base of reference in the choice of the optimal course of management for meniscal tears. Materials and Methods One hundred and seventeen patients met the criteria of inclusion for the present study. Patients were divided in two groups T and NT according to the presence of distinct previous traumatic events to the knees. Two subgroups were formed in each groups T and NT respectively at a mean follow up of 1 and 4 years. Postoperative clinical outcome were assessed using Lysholm scores and Rand SF-36 survey. Results One hundred and seventeen patients were included in the present study with 60(51.28%) patients in the traumatic group and 57(48.71%) in the degenerative group. 95(81.19%) patients in total were satisfied with their health status at end of follow up. The mean value of Lysholm scores at 1 year were respectively 85.25±8.78 for traumatic group and 86.38±12.14 for non-traumatic group and at 4 years were respectively 92.63±7.31 for traumatic group and 72.90±20.77 for non-traumatic group. According to Rand SF-36 health, traumatic group showed better improvements compare to non-traumatic group between 1 and 4 years after arthroscopic meniscus surgery. Conclusion A total of 95(81.19%) patients in total were satisfied with their health status at follow up, however, we found that arthroscopy as a treatment for meniscal tear have a relatively better mid-term clinical outcome for traumatic meniscal tears compare to non-traumatic/degenerative meniscal tears. PMID:27190905

  15. Five-year-olds are willing, but 4-year-olds refuse, to trust informants who offer new and unfamiliar labels for parts of the body.

    PubMed

    Luu, Betty; Rosnay, Marc de; Harris, Paul L

    2013-10-01

    This study employed the selective trust paradigm to examine how children interpret novel labels when compared with labels they already know to be accurate or inaccurate within the biological domain. The participants--3-, 4-, and 5-year-olds (N=144)--were allocated to one of three conditions. In the accurate versus inaccurate condition, one informant labeled body parts correctly, whereas the other labeled them incorrectly (e.g., calling an eye an "arm"). In the accurate versus novel condition, one informant labeled body parts accurately, whereas the other provided novel labels (e.g., calling an eye a "roke"). Finally, in the inaccurate versus novel condition, one informant labeled body parts incorrectly, whereas the other offered novel labels. In subsequent test trials, the two informants provided conflicting labels for unfamiliar internal organs. In the accurate versus inaccurate condition, children sought and endorsed labels from the accurate informant. In the accurate versus novel condition, only 4- and 5-year-olds preferred the accurate informant, whereas 3-year-olds did not selectively prefer either informant. In the inaccurate versus novel condition, only 5-year-olds preferred the novel informant, whereas 3- and 4-year-olds did not demonstrate a selective preference. Results are supportive of previous studies suggesting that 3-year-olds are sensitive to inaccuracy and that 4-year-olds privilege accuracy. However, 3- and 4-year-olds appear to be unsure as to how the novel informant should be construed. In contrast, 5-year-olds appreciate that speakers offering new information are more trustworthy than those offering inaccurate information, but they are cautious in judging such informants as being "better" at providing that information. PMID:23872524

  16. Compensation strategies for a lip-tube perturbation of French [u]: an acoustic and perceptual study of 4-year-old children.

    PubMed

    Ménard, Lucie; Perrier, Pascal; Aubin, Jero Me; Savariaux, Christophe; Thibeault, Mélanie

    2008-08-01

    The relations between production and perception in 4-year-old children were examined in a study of compensation strategies for a lip-tube perturbation. Acoustic and perceptual analyses of the rounded vowel [u] produced by twelve 4-year-old French speakers were conducted under two conditions: normal and with a 15-mm-diam tube inserted between the lips. Recordings of isolated vowels were made in the normal condition before any perturbation (N1), immediately upon insertion of the tube and for the next 19 trials in this perturbed condition, with (P2) or without articulatory instructions (P1), and in the normal condition after the perturbed trials (N2). The results of the acoustic analyses reveal speaker-dependent alterations of F1, F2, and/or F0 in the perturbed conditions and after the removal of the tube. For some subjects, the presence of the tube resulted in very little change; for others, an increase in F2 was observed in P1, which was generally reduced in some of the 20 repetitions, but not systematically and not continuously. The use of articulatory instructions provided in the P2 condition was detrimental to the achievement of a good acoustic target. Perceptual data are used to determine optimal combinations of F0, F1, and F2 (in bark) related to these patterns. The data are compared to a previous study conducted with adults [Savariaux et al., J. Acoust. Soc. Am. 106, 381-393 (1999)]. PMID:18681607

  17. Periodic cages.

    PubMed

    Diudea, Mircea V; Nagy, Csaba L; Silaghi-Dumitrescu, Ioan; Graovac, Ante; Janezic, Dusanka; Vikić-Topić, Drazen

    2005-01-01

    Various cages are constructed by using three types of caps: f-cap (derived from spherical fullerenes by deleting zones of various size), kf-cap (obtainable by cutting off the polar ring, of size k), and t-cap ("tubercule"-cap). Building ways are presented, some of them being possible isomerization routes in the real chemistry of fullerenes. Periodic cages with ((5,7)3) covering are modeled, and their constitutive typing enumeration is given. Spectral data revealed some electronic periodicity in fullerene clusters. Semiempirical and strain energy calculations complete their characterization. PMID:15807490

  18. Weight gain and reduced energy expenditure in low-income Brazilian women living in slums: a 4-year follow-up study.

    PubMed

    Florêncio, Telma M M T; Bueno, Nassib B; Clemente, Ana P G; Albuquerque, Fabiana C A; Britto, Revilane P A; Ferriolli, Eduardo; Sawaya, Ana L

    2015-08-14

    The present study aimed to investigate the possible changes in anthropometric and biochemical parameters in low-income women living in the outskirts of Maceió (northeast Brazil), and to explore the possible role of dietary intake and physical activity in these changes. A prospective longitudinal study was conducted in a cohort of mothers of malnourished children who attended the Center for Nutritional Recovery and Education, an outreach programme of the Federal University of Alagoas. Socio-economic, anthropometric, biochemical and dietary intake data were assessed at baseline and after a follow-up period of 4 years. Energy expenditure (using doubly labelled water) and physical activity (using triaxial accelerometers) were assessed only in a subgroup of women after 4 years. A total of eighty-five women were assessed. Participants showed an altered biochemical profile, increased systolic blood pressure, decreased thyroid hormone levels, and body-weight gain. However, dietary intakes of the participants did not include large quantities of highly processed and high-glycaemic index foods. The energy intake of the participants did not differ from their total energy expenditure (7990.3 (7173.7-8806.8) v. 8798.1 (8169.0-9432.4) kJ, respectively; P= 0.084). Multivariate analyses showed a significant effect of time spent watching television (β = 0.639 (0.003 to 1.275); P= 0.048) and dietary diversity score (β = -1.039 ( -2.010 to -0.067); P = 0.036) on weight gain. The present study indicates that poor women, who are mothers of malnourished children and have a reasonably balanced dietary intake, exhibit weight gain and are at risk of developing chronic diseases. PMID:26123236

  19. Comparison of analytical predictions of longitudinal short period pilot-induced oscillations with results from a simulation study of the space shuttle orbiter

    NASA Technical Reports Server (NTRS)

    Riley, D. R.; Miller, G. K., Jr.

    1982-01-01

    An analytical analysis of conditions producing pilot induced oscillations (PIO's) was made for the space shuttle orbiter in a landing approach configuration for the task of milling the elevation angle of the line of sight to a target vehicle. The analysis yielded a value of PIO frequency and a value for the amount of total system time delay (pilot + control system) that can be tolerated before instability results. Calculations were performed showing the effect of varying the range to the target and of varying the handling qualities of the orbiter vehicle. Analytical predictions were compared with simulation results obtained using a visual motion simulator.

  20. Visual Analysis of the Daily QA Results of Photon and Electron Beams of a Trilogy Linac over a Five-year Period

    PubMed Central

    Chan, Maria F.; Li, Qiongge; Tang, Xiaoli; Li, Xiang; Li, Jingdong; Tang, Grace; Hunt, Margie A.; Deasy, Joseph O.

    2016-01-01

    Data visualization technique was applied to analyze the daily QA results of photon and electron beams. Special attention was paid to any trend the beams might display. A Varian Trilogy Linac equipped with dual photon energies and five electron energies was commissioned in early 2010. Daily Linac QA tests including the output constancy, beam flatness and symmetry (radial and transverse directions) were performed with an ionization chamber array device (QA BeamChecker Plus, Standard Imaging). The data of five years were collected and analyzed. For each energy, the measured data were exported and processed for visual trending using an in-house Matlab program. These daily data were cross-correlated with the monthly QA and annual QA results, as well as the preventive maintenance records. Majority of the output were within 1% of variation, with a consistent positive/upward drift for all seven energies (~+0.25% per month). The baseline of daily device is reset annually right after the TG-51 calibration. This results in a sudden drop of the output. On the other hand, the large amount of data using the same baseline exhibits a sinusoidal behavior (cycle = 12 months; amplitude = 0.8%, 0.5% for photons, electrons, respectively) on symmetry and flatness when normalization of baselines is accounted for. The well known phenomenon of new Linac output drift was clearly displayed. This output drift was a result of the air leakage of the over-pressurized sealed monitor chambers for the specific vendor. Data visualization is a new trend in the era of big data in radiation oncology research. It allows the data to be displayed visually and therefore more intuitive. Based on the visual display from the past, the physicist might predict the trend of the Linac and take actions proactively. It also makes comparisons, alerts failures, and potentially identifies causalities.

  1. Excess Body Weight and 4-Year Function Outcomes: Comparison of African-Americans and Caucasians in the Osteoarthritis Initiative

    PubMed Central

    Colbert, Carmelita J.; Almagor, Orit; Chmiel, Joan S.; Song, Jing; Dunlop, Dorothy; Hayes, Karen W.; Sharma, Leena

    2012-01-01

    We evaluated whether African-Americans in the Osteoarthritis Initiative have a greater risk (vs. Caucasians) of poor 4-year function outcome within strata defined by gender, BMI, and waist circumference. Using WOMAC function, 20 meter walk, and chair stand performance, poor outcome was defined as moving into a worse function group or remaining in the 2 worst groups over 4 years. Logistic regression was used to evaluate the relationship between racial group and outcome within each stratum, adjusting for age, education, and income, and then further adjusting for BMI, comorbidity, depressive symptoms, physical activity, knee pain, and OA severity. In 3695 persons with or at higher risk for knee OA, higher BMI and large waist circumference were each associated with poor outcome. Among women with high BMI and among women with large waist circumference, African-Americans were at greater risk for poor outcome by every measure, adjusting for age, education, and income. From fully adjusted models, potential explanatory factors included income, comorbidity, depressive symptoms, pain, and disease severity. Findings were less consistent for men, emerging only for the 20 meter walk or chair stand outcomes, and potentially explained by age and knee pain. Among OAI women with excess body weight, African-Americans are at greater risk than Caucasians for poor 4-year outcome. Modifiable factors that may help to explain these findings in the OAI include comorbidity, depressive symptoms, and knee pain. Targeting such factors, while supporting weight loss, may help to lessen the outcome disparity between African-American and Caucasian women. PMID:22833527

  2. The Proportion of Women Who Have a Breast 4 Years after Breast Cancer Surgery: A Population-Based Cohort Study

    PubMed Central

    Mennie, Joanna C.; Mohanna, Pari-Naz; O’Donoghue, Joseph M; Rainsbury, Richard; Cromwell, David A.

    2016-01-01

    Background There are numerous pathways in breast cancer treatment, many of which enable women to retain a breast after treatment. We evaluated the proportion of women who have a breast, either through conserving surgery (BCS) or reconstruction, at 4-years after diagnosis, and how this varied by patient group. Methods and Findings We identified women with breast cancer who underwent initial BCS or mastectomy in English National Health Service (NHS) hospitals between January 2008 and December 2009 using the Hospital Episode Statistics (HES) database. Women were assigned into one of four patient groups depending on their age at diagnosis and presence of comorbidities. The series of breast cancer procedure (BCS, mastectomy, immediate, or delayed reconstruction) undergone by each women was identified over four years, and the proportion of women with a breast calculated. Variation was examined across patient groups, and English Cancer Networks. Between 2008 and 2009, 60,959 women underwent BCS or mastectomy. The proportion with a breast at 4 years was 79.3%, and 64.0%, in women less than 70 years without, and with comorbidities. Whilst in women aged 70 and over without, and with comorbidities, proportions were 52.6%, and 38.2%, respectively. Comorbidities were associated with lower proportions of BCS, but had little effect on reconstruction rates unlike age. Networks variation of 15% or more was found within each patient group, and Cancer Networks tended to have either a high or low proportion across all four patient groups. However, while 14% of women under 70 years had undergone reconstruction, less than 2% of women aged 70 or more had this treatment option. Conclusion The proportion of women diagnosed with breast cancer who retain a breast at 4 years is strongly associated with age, and presence of comorbidities. There was significant variation between Cancer Networks indicating that women’s experience in England was dependent on their geographical location of

  3. Prevalence of Obesity was Related to HLA-DQ in 2–4 Year Old Children at Genetic Risk for Type 1 Diabetes

    PubMed Central

    Yang, Jimin; Lernmark, Åke; Uusitalo, Ulla M.; Lynch, Kristian F.; Veijola, Riitta; Winkler, Christiane; Larsson, Helena Elding; Rewers, Marian; She, Jin-Xiong; Ziegler, Anette G.; Simell, Olli G.; Hagopian, William A.; Akolkar, Beena; Krischer, Jeffrey P.; Vehik, Kendra

    2014-01-01

    OBJECTIVES Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes. METHODS Repeated measures of weight and height were collected from 5 969 children 2–4 years of age enrolled in The Environmental Determinants of Diabetes in the Young prospective study. Overweight and obesity was determined by the International Obesity Task Force cutoff values that correspond to body mass index of 25 and 30 kg/m2 at age 18. RESULTS The average BMI was comparable across specific HLA genotypes at every age point. The proportion of overweight was not different by HLA, but percent obesity varied by age with a decreasing trend among DQ2/8 carriers (p for trend = 0.0315). A multivariable regression model suggested DQ2/2 was associated with higher obesity risk at age four (OR, 2.41; 95% CI, 1.21–4.80) after adjusting for the development of islet autoantibody and/or type 1 diabetes. CONCLUSIONS The HLA-DQ2/2 genotype may predispose to obesity among 2–4 year old children with genetic risk for type 1 diabetes. PMID:24694666

  4. Children's Comprehension of Sentences with Focus Particles and the Role of Cognitive Control: An Eye Tracking Study with German-Learning 4-Year-Olds.

    PubMed

    Höhle, Barbara; Fritzsche, Tom; Müller, Anja

    2016-01-01

    Children's interpretations of sentences containing focus particles do not seem adult-like until school age. This study investigates how German 4-year-old children comprehend sentences with the focus particle 'nur' (only) by using different tasks and controlling for the impact of general cognitive abilities on performance measures. Two sentence types with 'only' in either pre-subject or pre-object position were presented. Eye gaze data and verbal responses were collected via the visual world paradigm combined with a sentence-picture verification task. While the eye tracking data revealed an adult-like pattern of focus particle processing, the sentence-picture verification replicated previous findings of poor comprehension, especially for 'only' in pre-subject position. A second study focused on the impact of general cognitive abilities on the outcomes of the verification task. Working memory was related to children's performance in both sentence types whereas inhibitory control was selectively related to the number of errors for sentences with 'only' in pre-subject position. These results suggest that children at the age of 4 years have the linguistic competence to correctly interpret sentences with focus particles, which--depending on specific task demands--may be masked by immature general cognitive abilities. PMID:26930286

  5. Children’s Comprehension of Sentences with Focus Particles and the Role of Cognitive Control: An Eye Tracking Study with German-Learning 4-Year-Olds

    PubMed Central

    Höhle, Barbara; Fritzsche, Tom; Müller, Anja

    2016-01-01

    Children’s interpretations of sentences containing focus particles do not seem adult-like until school age. This study investigates how German 4-year-old children comprehend sentences with the focus particle ‘nur’ (only) by using different tasks and controlling for the impact of general cognitive abilities on performance measures. Two sentence types with ‘only’ in either pre-subject or pre-object position were presented. Eye gaze data and verbal responses were collected via the visual world paradigm combined with a sentence-picture verification task. While the eye tracking data revealed an adult-like pattern of focus particle processing, the sentence-picture verification replicated previous findings of poor comprehension, especially for ‘only’ in pre-subject position. A second study focused on the impact of general cognitive abilities on the outcomes of the verification task. Working memory was related to children’s performance in both sentence types whereas inhibitory control was selectively related to the number of errors for sentences with ‘only’ in pre-subject position. These results suggest that children at the age of 4 years have the linguistic competence to correctly interpret sentences with focus particles, which–depending on specific task demands–may be masked by immature general cognitive abilities. PMID:26930286

  6. A 4-year prospective evaluation of protocols to improve clinical outcomes for patients with lymphangioleiomyomatosis in a national clinical centre.

    PubMed

    Bee, Janet; Bhatt, Rupesh; McCafferty, Ian; Johnson, Simon R

    2015-12-01

    Lymphangioleiomyomatosis (LAM) is a rare multisystem disease. Progressive airflow limitation, pneumothorax and angiomyolipoma-related bleeding are major morbidities. As treatments are available for these complications, we prospectively audited loss of FEV1 (ΔFEV1), pneumothorax and angiomyolipoma bleeding against clinical standards over 4 years at the UK Clinical Centre. ΔFEV1 for these patients is lower than previously reported and rates of pneumothorax and angiomyolipoma haemorrhage are low. This suggests that real-time analysis of clinical data with targeted interventions can reduce morbidity in LAM. These measures could be applied as quality standards to compare the emerging LAM clinical networks worldwide. PMID:26123659

  7. Periodic Polymers

    NASA Astrophysics Data System (ADS)

    Thomas, Edwin

    2013-03-01

    Periodic polymers can be made by self assembly, directed self assembly and by photolithography. Such materials provide a versatile platform for 1, 2 and 3D periodic nano-micro scale composites with either dielectric or impedance contrast or both, and these can serve for example, as photonic and or phononic crystals for electromagnetic and elastic waves as well as mechanical frames/trusses. Compared to electromagnetic waves, elastic waves are both less complex (longitudinal modes in fluids) and more complex (longitudinal, transverse in-plane and transverse out-of-plane modes in solids). Engineering of the dispersion relation between wave frequency w and wave vector, k enables the opening of band gaps in the density of modes and detailed shaping of w(k). Band gaps can be opened by Bragg scattering, anti-crossing of bands and discrete shape resonances. Current interest is in our group focuses using design - modeling, fabrication and measurement of polymer-based periodic materials for applications as tunable optics and control of phonon flow. Several examples will be described including the design of structures for multispectral band gaps for elastic waves to alter the phonon density of states, the creation of block polymer and bicontinuous metal-carbon nanoframes for structures that are robust against ballistic projectiles and quasi-crystalline solid/fluid structures that can steer shock waves.

  8. Changes in body mass index in Canadians over a five-year period: Results of a prospective, population-based study

    PubMed Central

    Hopman, Wilma M; Leroux, Cristine; Berger, Claudie; Joseph, Lawrence; Barr, Susan I; Prior, Jerilynn C; Harrison, Mark; Poliquin, Suzette; Towheed, Tanveer; Anastassiades, Tassos; Goltzman, David

    2007-01-01

    Background The initiation of the Canadian Multicentre Osteoporosis Study in 1996, and subsequent follow-up of the cohort 5 years later, provided longitudinal body mass index (BMI) data for a random sample of Canadians. Methods Height and weight were measured at baseline and 5 years and used to calculate BMI and assign one of six weight categories. Multiple imputation was used to adjust for missing weight at year 5. Data were stratified by age and gender. The proportion of participants moving between categories was generated, and multivariable linear regression was used to identify factors associated with weight change. Results Baseline data were available for 8548 participants, year 5 data for 6721, and year 5 weight was imputed for 1827 (17.6%). Mean BMI for every age and gender group exceeded healthy weight guidelines. Most remained within their BMI classification over 5 years, but when change occurred, BMI category was more likely to increase than decrease. Several sociodemographic, lifestyle and clinical characteristics were associated with change. Conclusion Mean baseline BMI tended to be higher than recommended. Moreover, on average, men under age 45 and women under age 55 were gaining approximately 0.45 kilograms (one pound) per year, which leveled off with increased age and reversed in the oldest age groups. These findings underscore the need for public health efforts aimed at combating obesity. PMID:17620129

  9. [Ambulatory recording of esophageal pH over a 24-hour period in a population of 27 control subjects: analysis of technical and methodological factors influencing results].

    PubMed

    Gignoux, C; Bonnet-Eymard, P O; Hostein, J; Fournet, J

    1987-01-01

    Twenty-four hour pH monitoring is used increasingly as a technique for diagnosis of gastro-esophageal reflux (GER). The Synectics recording apparatus (Stockholm, Sweden) was used in 27 ambulatory control subjects in order to: identify the variations of the data-dependent factors (electrodes, buffer solutions, calibration, placement of esophageal electrode). The consequences of these variations were evaluated by studying the measurement deflection after 24 h, baseline variations, and a comparative double pH esophageal recording with reference equipment for 3 h postprandial; to provide normal values for several parameters of GER measurement under the conditions of this study (total number of reflux, number of reflux episodes longer than 5 min, duration of the longest reflux, percentage of time during which pH was less than 4.0). Important interindividual variations were observed. When interpreting the results provided by this type of apparatus, one should take into account these large variations due, first, to the technique used and second, to the conditions of ambulatory recording. PMID:3556956

  10. Psychosocial and Neurohormonal Predictors of HIV Disease Progression (CD4 Cells and Viral Load): A 4 Year Prospective Study.

    PubMed

    Ironson, G; O'Cleirigh, C; Kumar, M; Kaplan, L; Balbin, E; Kelsch, C B; Fletcher, M A; Schneiderman, N

    2015-08-01

    Most studies of psychosocial predictors of disease progression in HIV have not considered norepinephrine (NE), a neurohormone related to emotion and stress, even though NE has been related to accelerated viral replication in vitro and impaired response to antiretroviral therapy (ART). We therefore examined NE, cortisol, depression, hopelessness, coping, and life event stress as predictors of HIV progression in a diverse sample. Participants (n = 177) completed psychological assessment, blood draws [CD4, viral load (VL)], and a 15 h urine sample (NE, cortisol) every 6 months over 4 years. Hierarchical linear modeling (HLM) was used to model slope in CD4 and VL controlling for ART at every time point, gender, age, race, SES, and initial disease status. NE (as well as depression, hopelessness, and avoidant coping) significantly predicted a greater rate of decrease in CD4 and increase in VL. Cortisol was not significantly related to CD4, but predicted VL increase. To our knowledge, this is the first study relating NE, in vivo, to accelerated disease progression over an extended time. It also extends our previous 2 year study by relating depressed mood and coping to accelerated disease progression over 4 years. PMID:25234251

  11. Increased risk of severe vaso-occlusive episodes after initial acute chest syndrome in children with sickle cell anemia less than 4 years old: Sleep and asthma cohort.

    PubMed

    Vance, Leah D; Rodeghier, Mark; Cohen, Robyn T; Rosen, Carol L; Kirkham, Fenella J; Strunk, Robert C; DeBaun, Michael R

    2015-05-01

    Previous studies have shown that the highest incidence of acute chest syndrome (ACS) in sickle cell disease occurs in children <4 years old, and a history of ACS at this age is a risk factor for future ACS episodes. However, the interval associated with the highest risk of subsequent ACS or severe pain is not known. Through this mixed retrospective-prospective observational study, the Sleep and Asthma Cohort, we sought to determine the interval after an initial ACS episode during which the majority of children <4 years old are rehospitalized for ACS or severe pain. The cumulative prevalence of rehospitalization for ACS or severe pain within 6 months, 1 years, and 2 years was calculated for children with an initial ACS episode <4 years old and compared to children with an initial ACS episode ≥4 years old. A total of 44.8% and 55.2% of participants had an initial ACS episode <4 years and ≥4 years old (Range: 4-17.7 years), respectively. At 1 year following the initial ACS episode, children <4 years old had a significantly higher cumulative prevalence of rehospitalizations for ACS or pain as compared to children ≥4 years of age, 62.5 and 39.1%, respectively (P = 0.009). After initial ACS episodes, the majority of children <4 years old will be rehospitalized for ACS or severe pain within one year, suggesting the need for a therapeutic intervention for this high-risk group. PMID:25619382

  12. Mathematical learning instruction and teacher motivation factors affecting science technology engineering and math (STEM) major choices in 4-year colleges and universities: Multilevel structural equation modeling

    NASA Astrophysics Data System (ADS)

    Lee, Ahlam

    2011-12-01

    Using the Educational Longitudinal Study of 2002/06, this study examined the effects of the selected mathematical learning and teacher motivation factors on graduates' science, technology, engineering, and math (STEM) related major choices in 4-year colleges and universities, as mediated by math performance and math self-efficacy. Using multilevel structural equation modeling, I analyzed: (1) the association between mathematical learning instruction factors (i.e., computer, individual, and lecture-based learning activities in mathematics) and students' STEM major choices in 4-year colleges and universities as mediated by math performance and math self-efficacy and (2) the association between school factor, teacher motivation and students' STEM major choices in 4-year colleges and universities via mediators of math performance and math self-efficacy. The results revealed that among the selected learning experience factors, computer-based learning activities in math classrooms yielded the most positive effects on math self-efficacy, which significantly predicted the increase in the proportion of students' STEM major choice as mediated by math self-efficacy. Further, when controlling for base-year math Item Response Theory (IRT) scores, a positive relationship between individual-based learning activities in math classrooms and the first follow-up math IRT scores emerged, which related to the high proportion of students' STEM major choices. The results also indicated that individual and lecture-based learning activities in math yielded positive effects on math self-efficacy, which related to STEM major choice. Concerning between-school levels, teacher motivation yielded positive effects on the first follow up math IRT score, when controlling for base year IRT score. The results from this study inform educators, parents, and policy makers on how mathematics instruction can improve student math performance and encourage more students to prepare for STEM careers. Students

  13. Financial Results during Periods of Inflation.

    ERIC Educational Resources Information Center

    Thompson, James W.; Anderson, Richard E.

    1983-01-01

    The effects of inflation on the operations of 10 northeastern colleges and universities and the effect of using current cost accounting are considered. The focus is on adjustments to assets in the plant fund by restating the surplus and deficit calculations of four state and six private institutions. The 10 institutions had plant assets with an…

  14. Recent (<4 year old) Leaf Litter is Not a Major Source of Microbial Carbon in a Temperate Forest Mineral Soil

    SciTech Connect

    Kramer, Christiane; Trumbore, Susan E.; Froberg, Mats J.; Cisneros dozal, Luz Maria; Zhang, Dachun; Xu, Xiamei; Santos, Guaciara; Hanson, Paul J

    2010-01-01

    Microbial communities in soil A horizons derive their carbon from several potential sources: organic carbon (C) transported down from overlying litter and organic horizons, root-derived C, or soil organic matter. We took advantage of a multi-year experiment that manipulated the {sup 14}C isotope signature of surface leaf litter inputs in a temperate forest at the Oak Ridge Reservation, Tennessee, USA, to quantify the contribution of recent leaf litter C to microbial respiration and biomarkers in the underlying mineral soil. We observed no measurable difference (< {approx}40{per_thousand} given our current analytical methods) in the radiocarbon signatures of microbial phospholipid fatty acids (PLFA) isolated from the top 10 cm of mineral soil in plots that experienced 3 years of litterfall that differed in each year by {approx}750{per_thousand} between high-{sup 14}C and low-{sup 14}C treatments. Assuming any difference in {sup 14}C between the high- and low-{sup 14}C plots would reflect C derived from these manipulated litter additions, we estimate that <6% of the microbial C after 4 years was derived from the added 1-4-year-old surface litter. Large contributions of C from litter < 1 year (or >4 years) old (which fell after (or prior to) the manipulation and therefore did not differ between plots) are not supported because the {sup 14}C signatures of the PLFA compounds (averaging 200-220{per_thousand}) is much higher that of the 2004-5 leaf litter (115{per_thousand}) or pre-2000 litter. A mesocosm experiment further demonstrated that C leached from {sup 14}C-enriched surface litter or the O horizon was not a detectable C source in underlying mineral soil microbes during the first eight months after litter addition. Instead a decline in the {sup 14}C of PLFA over the mesocosm experiment likely reflected the loss of a pre-existing substrate not associated with added leaf litter. Measured PLFA {Delta}{sup 14}C signatures were higher than those measured in bulk

  15. A Successfully Treated Metastatic Choriocarcinoma Coexistent With Pregnancy: A Case Report of a 4-Year Follow-Up.

    PubMed

    Yu, Panxi; Diao, Wenqi; Jiang, Xuefeng

    2016-05-01

    Gestational choriocarcinoma ended with a successful parturition is extremely rare, especially in cases where multiple metastases occurred.A 29-year-old Chinese primigravida was admitted with vaginal bleeding at 32 gestational week, and diagnosed with gestational choriocarcinoma with vaginal, pulmonary, and cerebral metastasis after pathological, and imaging examination. At 33 gestational week, a healthy infant was delivered by cesarean section. Although no evidence of choriocarcinoma or any other forms of gestational trophoblastic diseases was found in the placenta and uterine curettages, the patient was given 7 cycles of postpartum chemotherapy. Her serum beta-human chorionic gonadotropin level fell to the normal range, and the metastatic lesions reduced. The baby is still free from diseases, and the patient reports no clinical manifestation 4 years after the hospital discharge.Despite its rapid metastases and complications, gestational choriocarcinoma still can be successfully treated by postpartum chemotherapy with the least delay. PMID:27227917

  16. Bilateral Thalamic and Right Fronto-temporo-parietal Gliomas in a 4 Years Old Child Diagnosed by Magnetic Resonance Imaging

    PubMed Central

    Sharaf, Ahmed Fathy; Hamouda, Ehab Shaban Mahmoud; Teo, Jennifer Gek Choo

    2016-01-01

    We report the neuroimaging findings of a 4-year-old girl with biopsy-proven bilateral thalamic and right fronto-temporo-parietal cortical gliomas, which are uncommon tumours involving the central nervous system. Despite their benignity, the prognosis is usually poor because of involvement of the thalamic nuclei and difficulty in surgical excision. These lesions have limited differential diagnoses that include metabolic, toxic, infective, vascular and neoplastic. Imaging characteristics on conventional Magnetic Resonance (MR), Magnetic Resonance Spectroscopy (MRS) and Diffusion tensor imaging (DTI) can further narrow the differential diagnosis and also provide additional information regarding the degree of involvement of adjacent brain tissue and white matter tracts around the lesions. PMID:27200150

  17. No aggression in a 4-year-old boy with an androgen-producing tumour: Case Report

    PubMed Central

    De la Marche, Wouter; Prinsen, Karin; Boot, Annemieke M; Ferdinand, Robert F

    2005-01-01

    Background The androgen testosterone plays a critical role in many aspects of sexual differentiation. Also, it is thought to induce aggressive behaviours or to play a role in social dominance. Case presentation In this case report a 4-year-old boy is described whose testosterone and dehydroepiandrosterone sulphate (DHEA-S) levels were raised to pubertal levels due to a testosterone producing testis tumour. This provided the unique opportunity to examine the effects of elevated levels of androgens on levels of aggression or on social dominance before the onset of puberty. Conclusion The present case report does not support the hypothesis of a causal relationship between testosterone and aggression or between testosterone and social dominance in young children. PMID:16202122

  18. Mineral trioxide aggregate pulpotomy in autotransplanted immature mandibular third molar with a 4-year follow-up.

    PubMed

    Dharmani, Umesh; Jadhav, Ganesh Ranganath; Kaur Dharmani, Charan Kamal; Devi, Takhellambam Premlata

    2016-01-01

    Autotransplantation is the surgical transposition of a tooth from its original site to another, replacing a lost or a compromised tooth by another tooth, usually the third molar in the same individual. This technique is considered a viable method due to its high success rate, well-grounded treatment option, provided the case selection and the procedure followed is within the acceptable limits. Autotransplantation is considered as an alternative approach of oral rehabilitations in a conservative manner mainly in young patients with compromised financial conditions to perform a high cost treatment. It is a fast way to recover function and aesthetic properties without interfering with the orofacial growth. This report describes a successful 4-year follow-up of a case of immediately performed mineral trioxide aggregate (MTA) pulpotomy in autotransplantated mandibular left immature third molar to replace the mandibular left first molar that was extracted due to extensive carious lesion. PMID:27217648

  19. Mineral trioxide aggregate pulpotomy in autotransplanted immature mandibular third molar with a 4-year follow-up

    PubMed Central

    Dharmani, Umesh; Jadhav, Ganesh Ranganath; Kaur Dharmani, Charan Kamal; Devi, Takhellambam Premlata

    2016-01-01

    Autotransplantation is the surgical transposition of a tooth from its original site to another, replacing a lost or a compromised tooth by another tooth, usually the third molar in the same individual. This technique is considered a viable method due to its high success rate, well-grounded treatment option, provided the case selection and the procedure followed is within the acceptable limits. Autotransplantation is considered as an alternative approach of oral rehabilitations in a conservative manner mainly in young patients with compromised financial conditions to perform a high cost treatment. It is a fast way to recover function and aesthetic properties without interfering with the orofacial growth. This report describes a successful 4-year follow-up of a case of immediately performed mineral trioxide aggregate (MTA) pulpotomy in autotransplantated mandibular left immature third molar to replace the mandibular left first molar that was extracted due to extensive carious lesion. PMID:27217648

  20. Emergency coronary artery bypass grafting for cardiogenic shock due to left main coronary artery obstruction caused by Kawasaki disease in a 4-year-old boy.

    PubMed

    Tamaki, Wataru; Tsuda, Etsuko; Nakajima, Hiroyuki; Kobayashi, Junjiro; Shiono, Junko

    2014-04-01

    We describe the case of a 4-year-old boy whose clinical course after Kawasaki disease resulted in coronary artery bypass grafting (CABG) due to acute myocardial infarction (AMI) causing cardiogenic shock. He had developed an ischemic cardiomyopathy due to severe localized stenosis of the left main coronary artery (LCA) and went into cardiogenic shock due to AMI on the day before a scheduled operation. He underwent successful emergency CABG within 4 h of MI. Postoperatively his neurological status was intact. This is the first report of a successful emergency CABG in a small child with cardiogenic shock due to LCA occlusion. CABG should be undertaken in small patients when appropriate indications exist, if bodyweight is >10 kg. PMID:24730632

  1. What physical performance measures predict incident cognitive decline among intact older adults? A 4.4year follow up study.

    PubMed

    Veronese, Nicola; Stubbs, Brendon; Trevisan, Caterina; Bolzetta, Francesco; De Rui, Marina; Solmi, Marco; Sartori, Leonardo; Musacchio, Estella; Zambon, Sabina; Perissinotto, Egle; Crepaldi, Gaetano; Manzato, Enzo; Sergi, Giuseppe

    2016-08-01

    Reductions in physical performance, cognitive impairment (CI) and decline (CD), are common in older age, but few prospective cohort studies have considered the relationship between these domains. In this study we investigated whether reduced physical performance and low handgrip/lower limbs strength, could predict a higher incidence of CI/CD during a 4-year follow-up among a cohort of elderly individuals. From 3099 older community-dwelling individuals initially enrolled in the Progetto Veneto Anziani (PRO.V.A.) study, 1249 participants without CI at the baseline were included (mean age 72.2years, 59.5% females). Physical performance measures included the Short Physical Performance Battery (SPPB), 4m gait speed, chair stands time, leg extension and flexion, handgrip strength, and 6-Minute Walking Test (6MWT), categorized in gender-specific tertiles. CI was defined as a Mini-Mental State Examination (MMSE) score below 24; CD a decline of 3 or more points in the MMSE without CI. At baseline, participants developing CI during follow-up scored significantly worse across all physical performance measures compared to those that retained normal cognitive status. After adjusting for potential confounders, a significant trend for MMSE changes was noted for all physical performance tests, except for the SPPB and chair stands time. Multinomial logistic regression revealed that slow gait speed at baseline significantly predicted CD at follow up. Poor SPPB performance and slower gait speed predicted the onset of CI at the follow-up. In conclusion, slow walking speed appears to be the best independent predictor of poor cognitive status over a 4.4-year follow-up, while other items of SPPB were also significantly associated with CI. PMID:27235850

  2. Ventriculo-bipleural shunt as last resort in a 4-year-old child in whom a VP and VA shunt failed.

    PubMed

    Ratliff, Miriam; Unterberg, Andreas; Bächli, Heidi

    2016-03-01

    The authors present the unusual case of a 4-year-old boy who had a complex history of posthemorrhagic hydrocephalus and who underwent more than 40 surgeries related to this condition. In the course of trying to treat his condition, ventriculoperitoneal, ventriculoatrial, and ventriculopleural shunts were inserted and failed. The child presented with a dysfunction of his shunt system. A ventriculopleural shunt was inserted, but within days the patient developed dyspnea as a clinical symptom of pleural effusion that required repeated thoracentesis. A bipleural drainage system was inserted, and no relevant pleural effusions developed during the follow-up period. Although the authors' experience is based on a single case, they do suggest bipleural drainage in patients with clinically relevant pleural effusions when the more common alternatives are not a good choice. Bipleural drainage might particularly be an option in children, who are prone to pleural effusion because of the smaller absorbing pleural surface. The authors reviewed the English-language literature on PubMed dating back to 1952. To their knowledge, this is the only published case in which a patient was treated with a ventriculo-bipleural shunt. PMID:26613270

  3. Effects of a Specialist-Led, School Physical Education Program on Bone Mass, Structure, and Strength in Primary School Children: A 4-Year Cluster Randomized Controlled Trial.

    PubMed

    Daly, Robin M; Ducher, Gaele; Hill, Briony; Telford, Rohan M; Eser, Prisca; Naughton, Geraldine; Seibel, Markus J; Telford, Richard D

    2016-02-01

    This 4-year cluster randomized controlled trial of 365 boys and 362 girls (mean age 8.1 ± 0.3 years) from grade 2 in 29 primary schools investigated the effects of a specialist-taught physical education (PE) program on bone strength and body composition. All children received 150 min/week of common practice (CP) PE from general classroom teachers but in 13 schools 100 min/week of CP PE was replaced by specialized-led PE (SPE) by teachers who emphasized more vigorous exercise/games combined with static and dynamic postural activities involving muscle strength. Outcome measures assessed in grades 2, 4, and 6 included: total body bone mineral content (BMC), lean mass (LM), and fat mass (FM) by DXA, and radius and tibia (4% and 66% sites) bone structure, volumetric density and strength, and muscle cross-sectional area (CSA) by pQCT. After 4-years, gains in total body BMC, FM, and muscle CSA were similar between the groups in both sexes, but girls in the SPE group experienced a greater gain in total body LM (mean 1.0 kg; 95% CI, 0.2 to 1.9 kg). Compared to CP, girls in the SPE group also had greater gains in cortical area (CoA) and cortical thickness (CoTh) at the mid-tibia (CoA, 5.0% [95% CI, 0.2% to 1.9%]; CoTh, 7.5% [95% CI, 2.4% to 12.6%]) and mid-radius (CoA, 9.3% [95% CI, 3.5% to 15.1%]; CoTh, 14.4% [95% CI, 6.1% to 22.7%]), whereas SPE boys had a 5.2% (95% CI, 0.4% to 10.0%) greater gain in mid-tibia CoTh. These benefits were due to reduced endocortical expansion. There were no significant benefits of SPE on total bone area, cortical density or bone strength at the mid-shaft sites, nor any appreciable effects at the distal skeletal sites. This study indicates that a specialist-led school-based PE program improves cortical bone structure, due to reduced endocortical expansion. This finding challenges the notion that periosteal apposition is the predominant response of bone to loading during the prepubertal and early-pubertal period. PMID:26260216

  4. Perceptions of veterinary admissions committee members of undergraduate credits earned from community colleges or online compared to traditional 4-year institutions

    PubMed Central

    Kogan, L.R.; Stewart, S.M.; Schoenfeld-Tacher, R.; Hellyer, P.W.

    2015-01-01

    Veterinary admission committees are asked to create and implement a fair, reliable, and valid system to select the candidates most likely to succeed in veterinary school from a large pool of applicants. Although numerous studies have explored grade point average (GPA) as a predictive value of later academic success, there has been little attention paid to how and where an applicant acquires his/her undergraduate coursework. Quality of academic program is an important component of applicant files, and it is suggested that the source of a candidate’s coursework might influence admissions committee decisions, perhaps even outside of the committee’s immediate awareness. Options for undergraduate education include taking classes at a traditional four-year institution, a community college, or online. This study provides an overview of the current state of online courses and community colleges in the US as a foundation to explore the views of veterinary admissions committee members pertaining to coursework completed at traditional residential 4-year schools or at community colleges and whether they are delivered on campus or online (at either type of institution). Survey participants reported a pattern of preference for traditional four-year residential coursework compared to online or community college courses. These results are interesting given the exponential growth of students taking online courses and data showing community colleges are providing a successful gateway to obtaining a four-year degree. This also points to the need for admission committees to discuss potential biases since the information about type of school and/or course may not be consistently available for all applicants. Finally, at a time when admitting a diverse class of students is a goal of many programs, it is of special concern that there are potential biases against courses taken online or from community colleges - venues that tend to draw a more diverse population than traditional 4

  5. Reduced Prevalence of Oral Human Papillomavirus (HPV) 4 Years after Bivalent HPV Vaccination in a Randomized Clinical Trial in Costa Rica

    PubMed Central

    Herrero, Rolando; Quint, Wim; Hildesheim, Allan; Gonzalez, Paula; Struijk, Linda; Katki, Hormuzd A.; Porras, Carolina; Schiffman, Mark; Rodriguez, Ana Cecilia; Solomon, Diane; Jimenez, Silvia; Schiller, John T.; Lowy, Douglas R.; van Doorn, Leen-Jan; Wacholder, Sholom; Kreimer, Aimée R.

    2013-01-01

    Background Human papillomavirus (HPV) infection, particularly with type 16, causes a growing fraction of oropharyngeal cancers, whose incidence is increasing, mainly in developed countries. In a double-blind controlled trial conducted to investigate vaccine efficacy (VE) of the bivalent HPV 16/18 vaccine against cervical infections and lesions, we estimated VE against prevalent oral HPV infections 4 years after vaccination. Methods and Findings A total of 7,466 women 18–25 years old were randomized (1∶1) to receive the HPV16/18 vaccine or hepatitis A vaccine as control. At the final blinded 4-year study visit, 5,840 participants provided oral specimens (91·9% of eligible women) to evaluate VE against oral infections. Our primary analysis evaluated prevalent oral HPV infection among all vaccinated women with oral and cervical HPV results. Corresponding VE against prevalent cervical HPV16/18 infection was calculated for comparison. Oral prevalence of identifiable mucosal HPV was relatively low (1·7%). Approximately four years after vaccination, there were 15 prevalent HPV16/18 infections in the control group and one in the vaccine group, for an estimated VE of 93·3% (95% CI = 63% to 100%). Corresponding efficacy against prevalent cervical HPV16/18 infection for the same cohort at the same visit was 72·0% (95% CI = 63% to 79%) (p versus oral VE = 0·04). There was no statistically significant protection against other oral HPV infections, though power was limited for these analyses. Conclusions HPV prevalence four years after vaccination with the ASO4-adjuvanted HPV16/18 vaccine was much lower among women in the vaccine arm compared to the control arm, suggesting that the vaccine affords strong protection against oral HPV16/18 infection, with potentially important implications for prevention of increasingly common HPV-associated oropharyngeal cancer. ClinicalTrials.gov, Registry number NCT00128661 PMID:23873171

  6. Sources of dietary fluoride intake in 4-year-old children residing in low, medium and high fluoride areas in Iran.

    PubMed

    Zohouri, F V; Rugg-Gunn, A J

    2000-09-01

    Accurate estimation of fluoride dietary intake is desirable for optimising caries prevention. Little is known about the dietary fluoride intake of children aged 4 years, an age when many permanent teeth are forming. This study was undertaken in Fars Province, Iran, in 1995-1996, where there are big differences in temperature between winter and summer. The aims were to determine: (a) the relative contributions of different components of the diet to fluoride intake, (b) the effect of variation in fluoride concentration in drinking water, and (c) the effect of climate temperature. Temperature varied between +40 degrees C in summer to -5 degrees C in winter. The mean fluoride concentrations in drinking water in the three areas were 0.3, 0.6 and 4.0 mgF/L. Dietary information was obtained by two 3-day diet diaries with interview, validated with reference to international standards. The fluoride content of foods was measured using the silicon-facilitated diffusion method. One hundred and three 4-year-old children completed the study. The mean (and 95% confidence interval) dietary fluoride intakes in each of the three areas, respectively, were 413 (+/- 21), 698 (+/- 89) and 3472 (+/- 557) micrograms/day. Drinks provided 72 to 87% of dietary fluoride--this proportion increased with increasing water fluoride concentration and increasing climate temperature. Tea (infusion) was an important source of dietary fluoride, providing 31 to 38% of total dietary intake. Tap water was a more important source of fluoride than soft drinks. Cooked rice and bread were the most important food source of fluoride and the amount of fluoride they contributed increased as water fluoride concentration increased. The results of this first such survey in the Middle East showed (a) that water (as a drink) and tea were by far the most important contributors to dietary fluoride intake, (b) substantial increases in fluoride intake with increasing water fluoride concentrations, and (c) substantially

  7. Minimum 4-year outcomes of cervical total disc arthroplasty versus fusion: a meta-analysis based on prospective randomized controlled trials.

    PubMed

    Wu, Ai-Min; Xu, Hui; Mullinix, Kenneth Paul; Jin, Hai-Ming; Huang, Zhe-Yu; Lv, Qing-Bo; Wang, Sheng; Xu, Hua-Zi; Chi, Yong-Long

    2015-04-01

    The prevalence of cervical disc disease is high, and the traditional surgical method of anterior cervical discectomy and fusion (ACDF) carries with it the disadvantages of motion loss at the operated level, and accelerated adjacent level disc degeneration. Preliminary results of the efficacy and reoperative rate comparing TDA versus ACDF have been reported; however, the long-term outcomes of TDA versus ACDF still remain a topic of debate. This review was prepared following the standard procedures set forth by the Cochrane Collaboration organization, and preferred reporting items for systematic reviews and meta-analyses (PRISMA). The only studies included were randomized controlled trials with a minimum of 4 years of follow-up data. The meta-analysis included the neck disability index (NDI), visual analog scale (VAS) of neck and arm pain, SF-36 physical component scores (SF-36 PCS), over success, neurological success, work status, implant-related complications, and secondary surgery events. Four randomized controlled trials meet the inclusion criteria. The long-term improvement of NDI, VAS of neck and arm pain, SF-36 PCS, over success, and neurological success favored the TDA group. The TDA group also had a lower incidence of secondary surgery for both the index level (RR: 0.45 [0.28, 0.72]) and adjacent level (RR: 0.53 [0.33, 0.88]). In this meta-analysis of 4 included RCTs with a minimum 4 years of follow-ups, total disc arthroplasty showed improvements over ACDF as measured by the NDI, VAS of neck and arm pain, and SF-36 PCS. PMID:25881841

  8. 5 CFR 930.108 - Periodic medical evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Periodic medical evaluation. 930.108... Operators § 930.108 Periodic medical evaluation. At least once every 4 years, each agency will ensure that..., the employee may be referred for a medical examination in accordance with the provisions of part...

  9. 5 CFR 930.108 - Periodic medical evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Periodic medical evaluation. 930.108 Section 930.108 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... Operators § 930.108 Periodic medical evaluation. At least once every 4 years, each agency will ensure...

  10. [The effect of selected prophylactic-educational programs on oral hygiene, periodontium and caries in school children during a 4-year observation].

    PubMed

    Grocholewicz, K

    1999-01-01

    stage of examinations was additionally evaluated and analysed thoroughly. The questionnaire studies made it possible to estimate the changes in the pro-health awareness among examined children. Reduction of OHI-S after 4 years was about 23% to 26% (Fig. 1). The status of gums shows the state of oral cavity hygiene in a better way. In control group the state remained unchanged, but in groups I, II and III it improved considerably (reduction of GI about 46% to 79%--Fig. 2). The reduction of caries in examined groups obtained after 4 years of studies was about 25% to 77% (Fig. 3) however during the second stage of research if figured out from 17% up to 72% (Fig. 4). Extreme increase of DS observed in the second stage of studies was 2.0 in control group K, a little less--1.51 in group I and 0.38 in group III (Fig. 5). The DS in group III reached the value -0.27 which proved that program III was the most efficient. The results of questionnaire studies showed a distinct improvement of health awareness among examined children. However the value of GI indicated some discrepancy between children's health knowledge and pro-health behaviour. Also it was noticed that the level of parents' education and their socioeconomic status had influence on building up good hygiene habits and on the state of caries among the examined children. The studies proved that the implementation of the above-mentioned prophylactic-educational programs or similar ones in elementary school conditions is possible with the use of hygienist under the dentist's supervision. PMID:10909495

  11. Associations of Fat Mass and Fat-Free Mass with Physical Fitness in 4-Year-Old Children: Results from the MINISTOP Trial.

    PubMed

    Henriksson, Pontus; Cadenas-Sanchez, Cristina; Leppänen, Marja H; Delisle Nyström, Christine; Ortega, Francisco B; Pomeroy, Jeremy; Ruiz, Jonatan R; Löf, Marie

    2016-01-01

    Physical fitness is a powerful marker of health in youth. Studies in adolescents and adults suggest that higher fat mass is related to worse physical fitness. However, there is limited knowledge whether fat mass and fat-free mass are associated with physical fitness already in preschoolers. Baseline data from the MINISTOP (Mobile-based INtervention Intended to STop Obesity in Preschoolers) trial was utilized for this cross-sectional analysis. Body composition was assessed using air-displacement plethysmography. Fat mass index [fat mass (kg)/height² (m)] and fat-free mass index [fat-free mass (kg)/height² (m)] were used to provide height-adjusted measures of body composition. Physical fitness was measured using the PREFIT (FITness testing in PREschool children) battery, which assesses cardiorespiratory fitness, upper-body and lower-body muscular strength as well as motor fitness. In total, this study included 303 children (168 boys and 135 girls), who were on average 4.48 ± 0.15 years old. Higher fat mass index was associated with worse cardiorespiratory fitness (standardized β = -0.17, p = 0.002), lower-body muscular strength (β = -0.17, p = 0.003) and motor fitness (β = -0.21, p < 0.001) in regression analyses adjusted for age, sex and mutually adjusted for fat-mass index and fat-free mass index. Conversely, higher fat-free mass index was associated with better cardiorespiratory fitness (β = 0.18, p = 0.002), upper-body muscular strength (β = 0.39, p < 0.001), lower-body muscular strength (β = 0.22, p < 0.001) and motor fitness (β = 0.17, p = 0.004). Thus, fat mass and fat-free mass in preschoolers appear to have joint but opposite associations with physical fitness, an important marker for current and future health. PMID:27483320

  12. Associations of Fat Mass and Fat-Free Mass with Physical Fitness in 4-Year-Old Children: Results from the MINISTOP Trial

    PubMed Central

    Henriksson, Pontus; Cadenas-Sanchez, Cristina; Leppänen, Marja H.; Delisle Nyström, Christine; Ortega, Francisco B.; Pomeroy, Jeremy; Ruiz, Jonatan R.; Löf, Marie

    2016-01-01

    Physical fitness is a powerful marker of health in youth. Studies in adolescents and adults suggest that higher fat mass is related to worse physical fitness. However, there is limited knowledge whether fat mass and fat-free mass are associated with physical fitness already in preschoolers. Baseline data from the MINISTOP (Mobile-based INtervention Intended to STop Obesity in Preschoolers) trial was utilized for this cross-sectional analysis. Body composition was assessed using air-displacement plethysmography. Fat mass index [fat mass (kg)/height2 (m)] and fat-free mass index [fat-free mass (kg)/height2 (m)] were used to provide height-adjusted measures of body composition. Physical fitness was measured using the PREFIT (FITness testing in PREschool children) battery, which assesses cardiorespiratory fitness, upper-body and lower-body muscular strength as well as motor fitness. In total, this study included 303 children (168 boys and 135 girls), who were on average 4.48 ± 0.15 years old. Higher fat mass index was associated with worse cardiorespiratory fitness (standardized β = −0.17, p = 0.002), lower-body muscular strength (β = −0.17, p = 0.003) and motor fitness (β = −0.21, p < 0.001) in regression analyses adjusted for age, sex and mutually adjusted for fat-mass index and fat-free mass index. Conversely, higher fat-free mass index was associated with better cardiorespiratory fitness (β = 0.18, p = 0.002), upper-body muscular strength (β = 0.39, p < 0.001), lower-body muscular strength (β = 0.22, p < 0.001) and motor fitness (β = 0.17, p = 0.004). Thus, fat mass and fat-free mass in preschoolers appear to have joint but opposite associations with physical fitness, an important marker for current and future health. PMID:27483320

  13. Setting the Periodic Table.

    ERIC Educational Resources Information Center

    Saturnelli, Annette

    1985-01-01

    Examines problems resulting from different forms of the periodic table, indicating that New York State schools use a form reflecting the International Union of Pure and Applied Chemistry's 1984 recommendations. Other formats used and reasons for standardization are discussed. (DH)

  14. Increased risk of severe vaso-occlusive episodes after initial acute chest syndrome in children with sickle cell anemia less than 4 years old: Sleep and Asthma Cohort

    PubMed Central

    Vance, Leah D; Rodeghier, Mark; Cohen, Robyn T.; Rosen, Carol L.; Kirham, Fenella J.; Strunk, Robert C.; DeBaun, Michael R.

    2015-01-01

    Previous studies have shown that the highest incidence of acute chest syndrome (ACS) in sickle cell disease (SCD) occurs in children less than 4 years old, and a history of ACS at this age is a risk factor for future ACS episodes. However, the interval associated with the highest risk of subsequent ACS or severe pain is not known. Through this mixed retrospective-prospective observational study, the Sleep and Asthma Cohort, we sought to determine the interval after an initial ACS episode during which the majority of children <4 years old are re-hospitalized for ACS or severe pain. The cumulative prevalence of re-hospitalization for ACS or severe pain within 6 months, 1 years, and 2 years was calculated for children with an initial ACS episode <4 years old and compared to children with an initial ACS episode ≥4 years old. A total of 44.8% and 55.2% of participants had an initial ACS episode <4 years and ≥4 years old (Range: 4-17.7 years), respectively. At 1 year following the initial ACS episode, children <4 years old had a significantly higher cumulative prevalence of re-hospitalizations for ACS or pain as compared to children ≥4 years of age, 62.5% and 39.1%, respectively (P = 0.009). After initial ACS episodes, the majority of children <4 years old will be re-hospitalized for ACS or severe pain within one year, suggesting the need for a therapeutic intervention for this high-risk group. PMID:25619382

  15. Use of quartz fiber post for reattachment of complex crown root fractures: A 4-year follow-up

    PubMed Central

    Hegde, Shubha G.; Tawani, Gopal S.; Warhadpande, Manjusha M.

    2014-01-01

    Dental hard tissue trauma is among the most common cases encountered in dental practice. Simple tooth fractures, which occur due to sharp blows, are widely seen in all age groups, especially in young adults. If in case of complex fractures the fractured tooth fragments are available to the dentist in a clean and hydrated state, reattachment of the tooth fragment is the most conservative and biological treatment option possible. Cases of enamel and dentin fractures not involving pulp are treated by reattaching the fragment with adhesives and composite resin. However, fractures involving the pulp require reinforcement by quartz fiber posts and resin luting cement. In cases of fractures extending subgingivally, an envelope flap helps to achieve the desired isolation and visibility. This article presents 2 case reports of reattachment of fractured tooth fragments. The first case showing a 4-year success was treated without raising a flap. The second case with a subgingival fracture was treated by raising a flap. Reattachment is the most economical, biologically acceptable and esthetic restorative option for dental trauma. PMID:25125857

  16. Children’s Spatial Representations: 3- and 4-Year-Olds are Affected by Irrelevant Peripheral References

    PubMed Central

    Krüger, Markus; Jahn, Georg

    2015-01-01

    Children as young as 3 years can remember an object’s location within an arrangement and can retrieve it from a novel viewpoint (Nardini et al., 2006). However, this ability is impaired if the arrangement is rotated to compensate for the novel viewpoint, or, if the arrangement is rotated and children stand still. There are two dominant explanations for this phenomenon: self-motion induces an automatic spatial updating process which is beneficial if children move around the arrangement, but misleading if the children’s movement is matched by the arrangement and not activated if children stand still and only the arrangement is moved (see spatial updating; Simons and Wang, 1998). Another explanation concerns reference frames: spatial representations might depend on peripheral spatial relations concerning the surrounding room instead on proximal relations within the arrangement, even if these proximal relations are sufficient or more informative. To evaluate these possibilities, we rotated children (N = 120) aged between 3 and 6 years with an occluded arrangement. When the arrangement was in misalignment to the surrounding room, 3- and 4-year-olds’ spatial memory was impaired and 5-year-olds’ was lightly impaired suggesting that they relied on peripheral references of the surrounding room for retrieval. In contrast, 6-years-olds’ spatial representation seemed robust against misalignment indicating a successful integration of spatial representations. PMID:26617537

  17. Antibodies to measles, mumps and rubella in UK children 4 years after vaccination with different MMR vaccines.

    PubMed

    Miller, E; Hill, A; Morgan-Capner, P; Forsey, T; Rush, M

    1995-06-01

    Persistence of antibodies 4 years after vaccination with measles, mumps and rubella (MMR) vaccine from three different manufacturers was compared in 475 children who received a single injection of vaccine when aged 12-18 months. Antibodies to measles and mumps were measured using a plaque reduction neutralisation assay; rubella antibodies were measured by radial haemolysis and latex agglutination. Children given MMR vaccine containing the Urabe mumps strain were less likely to be antibody negative than those given the Jeryl Lynn mumps strain (39/266, 15% vs 39/204, 19%, p = 0.048). However, the relatively high proportions in both groups without detectable mumps neutralising antibody suggests the probable need for a second dose in order to achieve mumps elimination. No significant differences were found in the proportions with detectable antibody to measles between vaccines containing the Schwarz and the Enders-Edmonston strains. Overall, only 3% of vaccinees were without detectable measles antibody, although a further 28% had a level below 200 mille International Units, the putative protective level for clinical measles. Geometric mean titres (GMTs) to measles were twofold higher in girls vaccinated after than before 14 months of age; GMTs in boys were intermediate and showed no age effect. Over 99% of vaccinees were seropositive to rubella, confirming the excellent immunogenicity of the RA 27/3 rubella strain and the potential for elimination of rubella with a single dose strategy. PMID:7483800

  18. The effects of perceptual priming on 4-year-olds' haptic-to-visual cross-modal transfer.

    PubMed

    Kalagher, Hilary

    2013-01-01

    Four-year-old children often have difficulty visually recognizing objects that were previously experienced only haptically. This experiment attempts to improve their performance in these haptic-to-visual transfer tasks. Sixty-two 4-year-old children participated in priming trials in which they explored eight unfamiliar objects visually, haptically, or visually and haptically together. Subsequently, all children participated in the same haptic-to-visual cross-modal transfer task. In this task, children haptically explored the objects that were presented in the priming phase and then visually identified a match from among three test objects, each matching the object on only one dimension (shape, texture, or color). Children in all priming conditions predominantly made shape-based matches; however, the most shape-based matches were made in the Visual and Haptic condition. All kinds of priming provided the necessary memory traces upon which subsequent haptic exploration could build a strong enough representation to enable subsequent visual recognition. Haptic exploration patterns during the cross-modal transfer task are discussed and the detailed analyses provide a unique contribution to our understanding of the development of haptic exploratory procedures. PMID:24494437

  19. Portion Size Variably Affects Food Intake of 6-year-old and 4-year-old Children in Kunming, China

    PubMed Central

    Smith, Lindsey; Conroy, Katharine; Wen, Hongmei; Rui, Li; Humphries, Debbie

    2015-01-01

    Age and portion size have been found to influence food intake in American children but have not been examined in an international context. This study evaluated the association between age and the effects of portion size on the food intake of kindergarteners in Kunming, China. Using a within-subjects crossover design in a classroom setting, 173 children in two age groups, mean age 4.2 years and 6.1 years, were served a predefined reference, small (-30%) and large (+30%) portion of rice, vegetables, and a protein source during lunchtime over three consecutive days. Each portion was weighed before and after the meal to determine amount of food consumed. Linear mixed modeling, controlling for repeated measures and clustering by classroom, was used to compare food intake under small and large portion size conditions to the reference portion. Children ate significantly less food when served small portions. When served a large portion, 6-year-old children increased food intake while 4-year-old children decreased food intake in comparison to the reference portion. Findings indicate that portion size affects food intake in Chinese children 4- to 6-years old. Older children show larger increases in food intake with increased portion size than do younger children. PMID:23702260

  20. Changes in White college students' color-blind racial ideology over 4 years: do diversity experiences make a difference?

    PubMed

    Neville, Helen A; Poteat, V Paul; Lewis, Jioni A; Spanierman, Lisa B

    2014-04-01

    In this longitudinal study, we explored how White students' (N = 857) color-blind racial ideology (CBRI; i.e., beliefs that serve to deny, minimize, and/or distort the existence of racism) changed over time and the factors associated with these patterns of change. Specifically, we investigated whether gender, diversity attitudes (i.e., openness to diversity and interest in social issues), and college diversity experiences (i.e., diversity-related courses/activities and close interracial friendships) predicted patterns of CBRI change. Findings indicated that gender and diversity attitudes were related to initial levels of CBRI, such that women and students who were more open to diversity issues at the beginning of college were more likely to report lower levels of CBRI; gender was also related to a greater decrease in CBRI changes over the college experience. Furthermore, college diversity experiences predicted changes in CBRI over time, such that students who completed a greater number of diversity courses and activities and those who had a greater number of close Black friends showed a significantly greater decrease in CBRI over their 4 years in college; interestingly, students who reported having no Latino friends compared with having some close Latino friends showed a significantly greater decrease in CBRI over time. PMID:24635589

  1. Gastrointestinal Fistulas in Acute Pancreatitis With Infected Pancreatic or Peripancreatic Necrosis: A 4-Year Single-Center Experience.

    PubMed

    Jiang, Wei; Tong, Zhihui; Yang, Dongliang; Ke, Lu; Shen, Xiao; Zhou, Jing; Li, Gang; Li, Weiqin; Li, Jieshou

    2016-04-01

    Gastrointestinal (GI) fistula is a well-recognized complication of acute pancreatitis (AP). However, it has been reported in limited literature. This study aimed to evaluate the incidence and outcome of GI fistulas in AP patients complicated with infected pancreatic or peripancreatic necrosis (IPN).Between 2010 and 2013 AP patients with IPN who diagnosed with GI fistula in our center were analyzed in this retrospective study. And we also conducted a comparison between patients with and without GI fistula regarding the baseline characteristics and outcomes.Over 4 years, a total of 928 AP patients were admitted into our center, of whom 119 patients with IPN were diagnosed with GI fistula and they developed 160 GI fistulas in total. Colonic fistula found in 72 patients was the most common form of GI fistula followed with duodenal fistula. All duodenal fistulas were managed by nonsurgical management. Ileostomy or colostomy was performed for 44 (61.1%) of 72 colonic fistulas. Twenty-one (29.2%) colonic fistulas were successfully treated by percutaneous drainage or continuous negative pressure irrigation. Mortality of patients with GI fistula did not differ significantly from those without GI fistula (28.6% vs 21.9%, P = 0.22). However, a significantly higher mortality (34.7%) was observed in those with colonic fistula.GI fistula is a common finding in patients of AP with IPN. Most of these fistulas can be successfully managed with different procedures depending on their sites of origin. Colonic fistula is related with higher mortality than those without GI fistula. PMID:27057908

  2. Transition from non-periodic to periodic explosions.

    PubMed

    Cartes, Carlos; Descalzi, Orazio

    2015-12-13

    We show the existence of periodic exploding dissipative solitons. These non-chaotic explosions appear when higher-order nonlinear and dispersive effects are added to the complex cubic-quintic Ginzburg-Landau equation modelling soliton transmission lines. This counterintuitive phenomenon is the result of period-halving bifurcations leading to order (periodic explosions), followed by period-doubling bifurcations (or intermittency) leading to chaos (non-periodic explosions). PMID:26527807

  3. Time-course of occupational psychological and social factors as predictors of new-onset and persistent neck pain: a three-wave prospective study over 4 years.

    PubMed

    Christensen, Jan Olav; Knardahl, Stein

    2014-07-01

    The current study estimated the impact of psychological and social work factors over time on neck pain. A sample of Norwegian employees (n=1250) was surveyed on 3 occasions spanning 4 years. Five exposures were studied: quantitative demands, decision control, social climate, empowering leadership, and role conflict. Group-based trajectory models suggested factors changed little over time-employees could be classified by mean levels of exposure into groups exhibiting stable "high", "middle", and "low" levels. The exception was decision control, for which a 4-level classification was derived: "high", "high-middle", "low-middle", and "low". Pain prevalence at the end of the study period was compared across groups. Risk and prognosis were also assessed separately by dividing the sample according to pain status at baseline. For all factors, distinct differences in risk were observed between exposure groups, controlled for pain at baseline, skill level, sex, and age. Statistically significant effects ranged from 0.38 (CI 0.20-0.73, P<0.01) for high social climate to 3.00 (CI 1.63-5.50, P<0.01) for high role conflict. The risk of new-onset pain was predicted by all factors. ORs ranged from 0.32 (CI 0.16-0.67, P<0.01) for high empowering leadership to 2.61 (CI 1.09-6.21, P<0.05) for high role conflict. Pain persistence was predicted by high role conflict (OR 3.26, CI 1.30-8.18, P<0.05), high quantitative demands (odds ratio [OR] 3.66, CI 1.58-8.49, P<0.01), and high-middle decision control (OR 0.45, CI 0.21-0.99, P<0.05). Future studies should collect information at multiple time points to clarify the impact of prolonged and changing exposure on musculoskeletal pain. PMID:24704365

  4. Learning to perceive English /d/ versus /edh/: A comparison of French, English, and English-French bilingual 4-year-olds

    NASA Astrophysics Data System (ADS)

    Sundara, Megha; Polka, Linda; Campisi, Lisa; Genesee, Fred; Marcoux, Caroline

    2002-05-01

    Recent findings show that discrimination of the English /d-edh/ does not differ for English and French infants (6-8-month-olds and 10-12-month-olds), although English adults clearly outperform French adults on this contrast, which is not phonemic in French. With respect to age effects, English listeners' perception of /d-edh/ improves between infancy and adulthood, whereas French listeners' perception remains unchanged [Polka et al., J. Acoust. Soc. Am. 109, 2190-2200 (2001)]. In the present study, we tested monolingual English, monolingual French, and early English-French bilingual 4-year-olds on the same contrast using the same stimuli and procedures to clarify when facilitative effects of language experience emerge and whether they are affected by bilingualism. Four findings are reported. First, a language effect (English>French) is evident by 4 years of age. Second, among native (English) listeners facilitative effects are evident by 4-years of age (infants<4-year-olds4-year-olds=adults). Fourth, bilingual 4-year-olds' performance is virtually identical to that of their French-speaking peers, revealing a strong effect of bilingualism on the perception of this contrast. Several factors contributing to these findings will be discussed.

  5. Genealogy of periodic trajectories

    SciTech Connect

    de Adguiar, M.A.M.; Maldta, C.P.; de Passos, E.J.V.

    1986-05-20

    The periodic solutions of non-integrable classical Hamiltonian systems with two degrees of freedom are numerically investigated. Curves of periodic families are given in plots of energy vs. period. Results are presented for this Hamiltonian: H = 1/2(p/sub x//sup 2/ + p/sub y//sup 2/) + 1/2 x/sup 2/ + 3/2 y/sup 2/ - x/sup 2/y + 1/12 x/sup 4/. Properties of the families of curves are pointed out. (LEW)

  6. The impact of the DoH Commissioning for Quality and Innovation incentive on the success of venous thromboembolism risk assessment in hospitalised patients. A single institution experience in a quality outcome improvement over a 4-year cycle

    PubMed Central

    Sandhu, Polly; Ali, Vernisha; Jones, Garth; Baker, Christopher

    2016-01-01

    Objectives To i) demonstrate compliance with the Commissioning for Quality and Innovation for venous thromboembolism risk assessment ii) to undertake root cause analysis of Hospital Acquired Thrombosis and to investigate its impact on quality of care. Design Prospective monitoring of all admissions. Setting Imperial College Healthcare Hospitals, London. Participants All Hospital Provider Spells as defined on the NHS Data Model and Dictionary. Main outcome measures i) Percentage of patients undergoing Venous Thromboembolism Risk Assessment (VTE-RA) at and 24-hours after admission ii) root cause analysis of Hospital Acquired Thrombosis up to 90 days following discharge. Results Over a 48-month cycle 83% were overall VTE-RA assessed with 36% in the first 12 months but with significant improvement to ≥95% between April 2013 and April 2015, achieving compliance target since April 2012 involving a massive 633, 850 Spells over the 4 year period. We undertook root cause analysis of all VTE episodes from April 2013 to March 2014, to ascertain Hospital Acquired Thrombosis (HAT), we analysed 433, 174 inpatient days and found a HAT rate of 1 per 1000 with 23% and 24% for DVTs and PEs potentially avoidable respectively. We further analysed VTE risk stratification (n = 1000) and found 37.0% at high risk, 44.4% at medium risk and 18.6 % at low risk, indicating the need of thromboprophylaxis in 81.4% (high and medium) of whom 33.6% were excluded. Conclusions We achieved 95% RA compliance which has favourably impacted on our daily practice and improved the quality of the clinical care. PMID:27293773

  7. Antibody Persistence at 1 and 4 Years Following a Single Dose of MenAfriVac or Quadrivalent Polysaccharide Vaccine in Healthy Subjects Aged 2–29 Years

    PubMed Central

    Diallo, Aldiouma; Sow, Samba O.; Idoko, Olubukola T.; Hirve, Siddhivinayak; Findlow, Helen; Preziosi, Marie-Pierre; Elie, Cheryl; Kulkarni, Prasad S.; Parulekar, Varsha; Diarra, Bou; Cheick Haidara, Fadima; Diallo, Fatoumata; Tapia, Milagritos; Akinsola, Adebayo K.; Adegbola, Richard A.; Bavdekar, Ashish; Juvekar, Sanjay; Chaumont, Julie; Martellet, Lionel; Marchetti, Elisa; LaForce, Marc F.; Plikaytis, Brian D.; Enwere, Godwin C.; Tang, Yuxiao; Borrow, Ray; Carlone, George; Viviani, Simonetta

    2015-01-01

    Background. Mass vaccination campaigns of the population aged 1–29 years with 1 dose of group A meningococcal (MenA) conjugate vaccine (PsA-TT, MenAfriVac) in African meningitis belt countries has resulted in the near-disappearance of MenA. The vaccine was tested in clinical trials in Africa and in India and found to be safe and highly immunogenic compared with the group A component of the licensed quadrivalent polysaccharide vaccine (PsACWY). Antibody persistence in Africa and in India was investigated. Methods. A total of 900 subjects aged 2–29 years were followed up for 4 years in Senegal, Mali, and The Gambia (study A). A total of 340 subjects aged 2–10 years were followed up for 1 year in India (study B). In study A, subjects were randomized in a 2:1 ratio, and in study B a 1:1 ratio to receive either PsA-TT or PsACWY. Immunogenicity was evaluated by measuring MenA serum bactericidal antibody (SBA) with rabbit complement and by a group A–specific immunoglobulin G (IgG) enzyme-linked immunosorbent assay. Results. In both studies, substantial SBA decay was observed at 6 months postvaccination in both vaccine groups, although more marked in the PsACWY group. At 1 year and 4 years (only for study A) postvaccination, SBA titers were relatively sustained in the PsA-TT group, whereas a slight increasing trend, more pronounced among the youngest, was observed in the participants aged <18 years in the PsACWY groups. The SBA titers were significantly higher in the PsA-TT group than in the PsACWY group at any time point, and the majority of subjects in the PsA-TT group had SBA titers ≥128 and group A–specific IgG concentrations ≥2 µg/mL at any point in time in both the African and Indian study populations. Conclusions. Four years after vaccination with a single dose of PsA-TT vaccine in Africa, most subjects are considered protected from MenA disease. Clinical Trials Registration. PsA-TT-003 (ISRCTN87739946); PsA-TT-003a (ISRCTN46335400). PMID

  8. Vascular access for hemodialysis. Patency rates and results of revision.

    PubMed Central

    Palder, S B; Kirkman, R L; Whittemore, A D; Hakim, R M; Lazarus, J M; Tilney, N L

    1985-01-01

    Over a 4-year interval, 324 arteriovenous conduits were created in 256 patients with end-stage renal disease as access for chronic hemodialysis. These included 154 Cimino fistulae, 163 polytetrafluoroethylene (PTFE) grafts, and seven miscellaneous grafts. Satisfactory patency rates were demonstrated for as long as 4 years for both Cimino fistulae and PTFE grafts by life-table analysis. Failures of Cimino fistulae usually occurred early in the postoperative period, secondary to attempts to use inadequate veins. Thrombosis caused the majority of PTFE graft failures and was generally the result of venous stenosis. Correction of such venous stenosis is mandatory to restore graft patency and can result in prolonged graft survival. PMID:4015229

  9. Does the Age and Familiarity of the Informant Group Influence the Tendency of 3- and 4-year-old Children to Conform?

    PubMed

    McGuigan, Nicola; Stevenson, Amy

    2016-01-01

    The authors' aim was to explore whether the age and the familiarity of the individuals comprising a group majority influenced the tendency of 3- and 4-year-old children to conform. Participants were presented with 2 variants of a novel task in which they were required to judge which of 3 line-drawn tigers had the greatest number of stripes. The participants made their judgments in 2 contexts, first after viewing 5 informants perform the task incorrectly, and second without viewing the responses of other individuals. The informants comprised a group of familiar children, a group of unfamiliar children, a group of familiar adults, or a group of unfamiliar adults. The results showed that the children displayed selective conformity with respect to informant age, readily adopting the incorrect response when it was indicated by an adult majority, but failing to do so when the same incorrect response was indicated by a majority of children. In contrast the familiarity of the individuals comprising the majority had little influence on the tendency of children to conform. These results suggest that children are not blanket conformists, rather they respond selectively depending on characteristics of the individuals comprising the group majority. PMID:27341477

  10. False belief understanding and “cool” inhibitory control in 3-and 4-years-old Italian children

    PubMed Central

    Bellagamba, Francesca; Addessi, Elsa; Focaroli, Valentina; Pecora, Giulia; Maggiorelli, Valentina; Pace, Beatrice; Paglieri, Fabio

    2015-01-01

    During preschool years, major developments occur in both executive function and theory of mind (ToM), and several studies have demonstrated a correlation between these processes. Research on the development of inhibitory control (IC) has distinguished between more cognitive, “cool” aspects of self-control, measured by conflict tasks, that require inhibiting an habitual response to generate an arbitrary one, and “hot,” affective aspects, such as affective decision making, measured by delay tasks, that require inhibition of a prepotent response. The aim of this study was to investigate the relations between 3- and 4-year-olds’ performance on a task measuring false belief understanding, the most widely used index of ToM in preschoolers, and three tasks measuring cognitive versus affective aspects of IC. To this end, we tested 101 Italian preschool children in four tasks: (a) the Unexpected Content False Belief task, (b) the Conflict task (a simplified version of the Day–Night Stroop task), (c) the Delay task, and (d) the Delay Choice task. Children’s receptive vocabulary was assessed by the Peabody Picture Vocabulary test. Children’s performance in the False Belief task was significantly related only to performance in the Conflict task, controlling for vocabulary and age. Importantly, children’s performance in the Conflict task did not significantly correlate with their performance in the Delay task or in the Delay Choice task, suggesting that these tasks measure different components of IC. The dissociation between the Conflict and the Delay tasks may indicate that monitoring and regulating a cool process (as flexible categorization) may involve different abilities than monitoring and regulating a hot process (not touching an available and highly attractive stimulus or choosing between a smaller immediate option and a larger delayed one). Moreover, our findings support the view that “cool” aspects of IC and ToM are interrelated, extending to an

  11. Caries experience in the primary dentition and presence of plaque in 7-year-old Chinese children: A 4-year time-lag study

    PubMed Central

    Hu, Xuan; Fan, Mingwen; Mulder, Jan; Frencken, J. E.

    2015-01-01

    Objectives: The aim of the present study was to test the hypothesis that dental caries prevalence and caries experience in primary dentitions has increased over 4 years and to compare the presence of plaque on permanent teeth in child cohorts over 4 years. Materials and Methods: A time-lag study design was used comprising two cohorts of children aged 7 years from the same five primary schools in Wuhan examined in 2007 and 2011. Two calibrated examiners visually assessed plaque accumulation according to the Greene and Vermillion Index and the dentitions according to the Atraumatic Restorative Treatment (ART) caries criteria. Analysis of variance (ANOVA), logistic regression, and Chi-square test were used to test for differences between dependent and independent variables. Results: The 2007 sample consisted of 817 children and the 2011 sample consisted of 1010 children. The prevalence of dental caries (d3mft) was 68.2% in 2007 and 67.7% in 2011, while that of d2mft was 78.5% in 2007 and 71.4% in 2011 (P < 0.0006). The mean d3mft score was 2.8 in 2007 and 3.1 in 2011 (P = 0.046), while the mean d3mfs score was 4.9 in 2007 and 7.3 in 2011 (P < 0.0001). The d3-component of the d3mft index was 73% in 2007 and 69% in 2011, while the f-component was 22% in 2007 and 26% in 2011. The hypothesis was not accepted. The proportion of children with plaque code 3 (extensive coverage) was higher in 2011 (21.8%) than in age mates in 2007 (5.7%). Conclusions: There were no obvious signs that dental caries prevalence had been increased in primary dentitions of this child population between 2007 and 2011. But as the mean caries experience scores at the surface level were higher in 2011 than in 2007, monitoring caries prevalence remains essential, but should start at an earlier age than that covered by this study. Health and educational authorities should collaborate in setting up programs aimed at ensuring good oral health for school children. PMID:26236680

  12. Micronutrient Fortified Milk Improves Iron Status, Anemia and Growth among Children 1–4 Years: A Double Masked, Randomized, Controlled Trial

    PubMed Central

    Sazawal, Sunil; Dhingra, Usha; Dhingra, Pratibha; Hiremath, Girish; Sarkar, Archana; Dutta, Arup; Menon, Venugopal P.; Black, Robert E.

    2010-01-01

    Background Multiple micronutrient deficiencies are highly prevalent among preschool children and often lead to anemia and growth faltering. Given the limited success of supplementation and health education programs, fortification of foods could be a viable and sustainable option. We report results from a community based double-masked, randomized trial among children 1–4 years evaluating the effects of micronutrients (especially of zinc and iron) delivered through fortified milk on growth, anemia and iron status markers as part of a four group study design, running two studies simultaneously. Methods and Findings Enrolled children (n = 633) were randomly allocated to receive either micronutrients fortified milk (MN = 316) or control milk (Co = 317). Intervention of MN milk provided additional 7.8 mg zinc, 9.6 mg iron, 4.2 µg selenium, 0.27 mg copper, 156 µg vitamin A, 40.2 mg vitamin C, and 7.5 mg vitamin E per day (three serves) for one year. Anthropometry was recorded at baseline, mid- and end-study. Hematological parameters were estimated at baseline and end-study. Both groups were comparable at baseline. Compliance was over 85% and did not vary between groups. Compared to children consuming Co milk, children consuming MN milk showed significant improvement in weight gain (difference of mean: 0.21 kg/year; 95% confidence interval [CI] 0.12 to 0.31, p<0.001) and height gain (difference of mean: 0.51 cm/year; 95% CI 0.27 to 0.75, p<0.001). Mean hemoglobin (Hb) (difference of 13.6 g/L; 95% CI 11.1 to 16.0, p<0.001) and serum ferritin levels (difference of 7.9 µg/L; 95% CI 5.4 to 10.5, p<0.001) also improved. Children in MN group had 88% (odds ratio = 0.12, 95% CI 0.08 to 0.20, p<0.001) lower risk of iron deficiency anemia. Conclusions/Significance Milk provides an acceptable and effective vehicle for delivery of specific micronutrients, especially zinc and iron. Micronutrient bundle improved growth and iron status and reduced anemia in children

  13. An Inquiry-based Instruction Model Designed to Recruit and Retain 2-year and 4-year Early Underclassmen and Undeclared Students into Biogeoscience Majors

    NASA Astrophysics Data System (ADS)

    Hale, S.; Rock, B. N.; Hayden, L. B.; Perry, C.; Barber, L.

    2010-12-01

    From 2006-2009, the Watershed Watch Program (NSF DUE #0525433) engaged early undergraduates and undeclared students in a student-directed, full-inquiry summer course and an academic year (AY) seminar course with engaging research interactions. Student from 4-year institutions (University of New Hampshire, Elizabeth City State University) and 2-year institutions (Great Bay Community College, College of the Albemarle) participated jointly in this program. The largest number of students (50) came from Elizabeth City State University, which is a Historically Black University. Results from this developing program indicate that undeclared students in Watershed Watch declare STEM majors at double the rate of undeclared students not in Watershed Watch. Comparison data from institution with small institutional research capacity makes direct comparisons challenging, but indicate higher rates of STEM major retention. Factors that contributed most to higher STEM major declaration rates included mentoring faculty qualities, opportunity for student-directed learning, conducting field research, minimizing lecture instruction, and student attainment of high standards for research, which imparted a high self-confidence for students to do science.

  14. Trace elements, pH and organic matter evolution in contaminated soils under assisted natural remediation: a 4-year field study.

    PubMed

    Madejón, E; Madejón, P; Burgos, P; Pérez de Mora, A; Cabrera, F

    2009-03-15

    A 4-year study was undertaken on the effect of three amendments (biosolid compost (BC), sugar beet lime (SL), and combination of leonardite plus sugar beet lime (LESL)) on reclamation of a moderately trace element-contaminated soil under field conditions. Results showed that organic C increased in BC and LESL treatments. BC and SL treatments increased soil pH and reduced CaCl(2)-extractable metal concentrations more efficiently. At the end of the experiment, CaCl(2)-extractable metal concentrations decreased and were similar in all treatments pointing out the importance of the natural remediation processes in contaminated soils. Addition of amendments showed no clear reduction in EDTA-extractable trace element concentrations, even, BC and LESL subplots showed some little increase of these elements with time. Amendments did not cause any change in total trace element concentration in soil. Addition of amendments could be a successful and reliable long term technique for stabilization of trace elements in contaminated soils at a field scale with minimum maintenance. PMID:18602216

  15. Environmental surveillance and molecular epidemiology of waterborne pathogen Legionella pneumophila in health-care facilities of Northeastern Greece: a 4-year survey.

    PubMed

    Alexandropoulou, Ioanna G; Ntougias, Spyridon; Konstantinidis, Theocharis G; Parasidis, Theodoros A; Panopoulou, Maria; Constantinidis, Theodoros C

    2015-05-01

    A 4-year proactive environmental surveillance of Legionella spp. in the water distribution and cooling systems of five health-care facilities was carried out as part of the strategy for the prevention of hospital-acquired Legionnaires' disease in Northeastern Greece. Legionella spp. were detected in 71 out of 458 collected samples. The majority of strains belonged to Legionella pneumophila serogroups 2-15 (75.0%), while all L. pneumophila serogroup 1 strains (23.6%) were isolated from a single hospital. The highest percentage of positive samples was found in distal sites (19.4%), while no Legionella strains were detected in cooling systems. Each hospital was colonized at least once with L. pneumophila, while remedial actions resulted in significant reduction of Legionella concentration. The molecular epidemiology of environmental L. pneumophila strains was also investigated using random amplified polymorphic DNA (RAPD) and multi-gene sequence-based analysis. Based on RAPD patterns, L. pneumophila serogroups 2-15 and serogroup 1 strains were classified into 24 and 9 operational taxonomic units (OTUs), respectively. Sequencing of housekeeping and diversifying pressure-related genes recommended by European Working Group for Legionella Infections (EWGLI) revealed not only a high intraspecies variability but also the circulation and persistence of one specific genotyping profile in the majority of hospitals. This study highlights the necessity for diachronic surveillance of Legionella in health-care facilities by adopting both cultural and molecular methods. PMID:25712880

  16. Associations between Maternal Scaffolding and Executive Functioning in 3 and 4 Year Olds Born Very Low Birth Weight and Normal Birth Weight

    PubMed Central

    Lowe, Jean; Erickson, Sarah J.; MacLean, Peggy; Duvall, Susanne W.; Ohls, Robin K.; Duncan, Andrea F.

    2014-01-01

    Background Deficits in executive function, including measures of working memory, inhibition and cognitive flexibility, have been documented in preschoolers born very low birth weight (VLBW) compared with preschoolers born with normal birth weight (NBW). Maternal verbal scaffolding has been associated with positive outcomes for both at-risk and typically developing preschoolers. Aims The purpose of this study was to examine associations between maternal verbal scaffolding, Verbal IQ (VIQ) and executive function measures in preschoolers born VLBW. Subjects A total of 64 VLBW and 40 NBW preschoolers ranging in age from 3 ½ to 4 years participated in the study. Outcome Measures VIQ was measured with the Wechsler Preschool and Primary Scale of Intelligence – 3rd edition. Executive function tests included the Bear Dragon, Gift Delay Peek, Reverse Categorization and Dimensional Change Card Sort-Separated Dimensions. Study Design Maternal verbal scaffolding was coded during a videotaped play session. Associations between maternal verbal scaffolding and preschoolers’ measures of VIQ and executive function were compared. Covariates included test age, maternal education, and gender. Results Preschoolers born VLBW performed significantly worse on VIQ and all executive function measures compared to those born NBW. Maternal verbal scaffolding was associated with VIQ for VLBW preschoolers and Gift Delay Peek for the NBW group. Girls born VLBW outperformed boys born VLBW on VIQ and Bear Dragon. Conclusion Integrating scaffolding skills training as part of parent-focused intervention may be both feasible and valuable for early verbal reasoning and EF development. PMID:25127288

  17. Period variations in SZ ARIETIS

    NASA Astrophysics Data System (ADS)

    Srivastava, R. K.

    1990-06-01

    Results are presented of a detailed period study of the eclipsing binary system SZ Arietis, based on up-to-date collection of minima. A new period (P = 1.7175405 d) of the SZ Ari was found, and the period changes (with the new period) in different portions of the O-C diagram were estimated. The average period change (leaving out an unusual value) was estimated to be about 0.00006 d. The O-C diagram displayed a sinusoidal variation, indicating that the SZ Ari system may be a three-body system, having a period of nearly 66 years.

  18. Two-Year Community: Cultivating the STEM Transfer Pathway and Capacity for Research: A Partnership between a Community College and a 4-Year College

    ERIC Educational Resources Information Center

    Hirst, Rachel A.; Bolduc, Gilles; Liotta, Louis; Packard, Becky Wai-Ling

    2014-01-01

    Summer research experiences have been identified as important vehicles for fostering the learning, skill development, and retention of undergraduates in the sciences. In this initiative, community college faculty and students partnered with private 4-year college colleagues on summer research in order to expand the capacity for research for…

  19. Predicting the Persistence of Full-Time African-American Students Attending 4-Year Public Colleges: A Disaggregation of Financial Aid Packaging and Social and Academic Integration Variables

    ERIC Educational Resources Information Center

    Smith, Curt L.

    2010-01-01

    The purpose of the study was to investigate to what extent do demographic characteristics, high school experience, aspirations and achievement, college experience-academic integration, college experience-social integration, financial aid, and price influence the first-year persistence of African-American students attending 4-year public colleges.…

  20. Is the Community College a Less Expensive Path toward a Bachelor's Degree? Public 2- and 4-Year Colleges' Impact on Loan Debt

    ERIC Educational Resources Information Center

    Canché, Manuel S. González

    2014-01-01

    Policy makers and state representatives have claimed that, compared to the traditional path to a four-year degree, a course of study that begins in the 2-year sector provides a more affordable option. If this is true, then all else equal, 2-year students who obtained a 4-year degree would be expected to have acquired less student loan debt. To…

  1. Looking but Not Seeing: Atypical Visual Scanning and Recognition of Faces in 2 and 4-Year-Old Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Chawarska, Katarzyna; Shic, Frederick

    2009-01-01

    This study used eye-tracking to examine visual scanning and recognition of faces by 2- and 4-year-old children with autism spectrum disorder (ASD) (N = 44) and typically developing (TD) controls (N = 30). TD toddlers at both age levels scanned and recognized faces similarly. Toddlers with ASD looked increasingly away from faces with age,…

  2. Academic Transfer Shock and Social Integration: A Comparison of Outcomes for Traditional and Nontraditional Students Transferring from 2-Year to 4-Year Institutions

    ERIC Educational Resources Information Center

    Strahn-Koller, Brooke Lindsey

    2012-01-01

    The purpose of this study was to explore whether traditional and nontraditional students who transferred from 2-year to 4-year institutions experienced differences in transfer shock, academic integration, and social integration. A substantial body of knowledge comparing transfer students to native students on transfer shock exists, while only a…

  3. Special Education in a 4-Year Response to Intervention (RtI) Environment: Characteristics of Students with Learning Disability and Grade of Identification

    ERIC Educational Resources Information Center

    O'Connor, Rollanda E.; Bocian, Kathleen M.; Beach, Kristen D.; Sanchez, Victoria; Flynn, Lindsay J.

    2013-01-01

    This 4-year longitudinal research was designed to study special education determinations of students who participated in Tier 2 intervention in a Response to Intervention (RtI) model focused on reading across Grades 1-4. We compared identification rates for learning disabilities (LD) and student characteristics of 381 students the year prior to…

  4. Professional Leadership Experiences with Formal and Informal Mentoring of College Deans of Education at 4-Year Nonprofit Private Colleges and Universities in California

    ERIC Educational Resources Information Center

    Baartman, Ingrid

    2011-01-01

    Purpose: The purpose of this study was to examine professional leadership experiences of college deans of education with formal and informal mentoring in the course of their career progression at 4-year nonprofit private colleges and universities in California. Methodology: Using a mixed-methods approach that emphasized the qualitative data…

  5. Compositionality and Statistics in Adjective Acquisition: 4-Year-Olds Interpret "Tall" and "Short" Based on the Size Distributions of Novel Noun Referents

    ERIC Educational Resources Information Center

    Barner, David; Snedeker, Jesse

    2008-01-01

    Four experiments investigated 4-year-olds' understanding of adjective-noun compositionality and their sensitivity to statistics when interpreting scalar adjectives. In Experiments 1 and 2, children selected "tall" and "short" items from 9 novel objects called "pimwits" (1-9 in. in height) or from this array plus 4 taller or shorter distractor…

  6. Faculty Perceptions of Factors Affecting Faculty Attrition and Retention at 4-Year Public Colleges and Universities in One Southern North American State

    ERIC Educational Resources Information Center

    Rhone, Denton W.

    2010-01-01

    The purpose of this study was to identify the perceptions of faculty at selected 4-year public colleges and universities in the state of Georgia regarding factors that would influence them to leave or remain at their respective institutions. This study uses a quantitative descriptive design, utilizing an online survey with 20 intrinsic and…

  7. Developing a General Outcome Measure of Growth in the Cognitive Abilities of Children 1 to 4 Years Old: The Early Problem-Solving Indicator

    ERIC Educational Resources Information Center

    Greenwood, Charles R.; Walker, Dale; Carta, Judith J.; Higgins, Susan K.

    2006-01-01

    Proficiency in problem solving is an important outcome in early childhood necessary for cognitive and emotional development. The development of an individual growth and development indicator of problem solving for children 1 to 4 years of age is described. Based on the general outcome measurement approach (Deno, 1997), the measure is intended for…

  8. A STABLE ISOTOPE ANALYSIS OF SOIL CARBON DENSITY FRACTIONS FOLLOWING 4 YEARS OF CONTINUOUS CLIMATE CHANGE EXPOSURE IN A DOUGLAS FIR MESOCOSM STUDY

    EPA Science Inventory

    We conducted a 4-year full-factorial study of the effects of elevated atmospheric CO2 and temperature on Douglas fir seedlings growing in reconstructed native forest soils in mesocosms. The elevated CO2 treatment was ambient CO2 plus 200 ppm CO2. The elevated temperature treatm...

  9. The Everyday Mathematical Experiences and Understandings of Three, 4-Year-Old, African-American Children from Working-Class Backgrounds

    ERIC Educational Resources Information Center

    Benigno, Grace Marie R.

    2012-01-01

    This qualitative study examined the everyday mathematical experiences and understandings of three, 4-year-old, African-American children from working-class backgrounds. The study drew on Street, Baker, and Tomlin's (2005) broad, ideological model of mathematics as "social" and their analytic concepts of mathematical events (units of…

  10. Baccalaureate and Beyond: A First Look at the Employment Experiences and Lives of College Graduates, 4 Years On (B&B:08/12). NCES 2014-141

    ERIC Educational Resources Information Center

    Cataldi, Emily Forrest; Siegel, Peter; Shepherd, Bryan; Cooney, Jennifer

    2014-01-01

    This report presents initial findings about the employment outcomes of bachelor's degree recipients approximately 4 years after they completed their 2007-08 degrees. These findings are based on data from the second follow-up of the Baccalaureate and Beyond Longitudinal Study (B&B:08/12), a nationally representative longitudinal sample…

  11. Focus Particles in Children's Language: Production and Comprehension of "Auch" "Also" in German Learners from 1 Year to 4 Years of Age

    ERIC Educational Resources Information Center

    Hohle, Barbara; Berger, Frauke; Muller, Anja; Schmitz, Michaela; Weissenborn, Jurgen

    2009-01-01

    This article investigates the acquisition of the focus particle "auch" "also" by German-learning children. We report data from spontaneous and elicited production of utterances with the focus particle "auch" by 1- to 4-year-olds complementing earlier findings of a delayed production of the unaccented "auch" compared to the accented one. But in…

  12. Immune response to the HPV-16/18 AS04-adjuvanted vaccine administered as a 2-dose or 3-dose schedule up to 4 years after vaccination

    PubMed Central

    Romanowski, Barbara; Schwarz, Tino F; Ferguson, Linda M; Ferguson, Murdo; Peters, Klaus; Dionne, Marc; Schulze, Karin; Ramjattan, Brian; Hillemanns, Peter; Behre, Ulrich; Suryakiran, Pemmaraju; Thomas, Florence; Struyf, Frank

    2014-01-01

    This randomized, partially-blind study (ClinicalTrials.gov registration number NCT00541970) evaluated the immunogenicity and safety of 2-dose (2D) schedules of the HPV-16/18 AS04-adjuvanted vaccine. Results to month (M) 24 have been reported previously and we now report data to M48 focusing on the licensed vaccine formulation (20 μg each of HPV-16 and -18 antigens) administered at M0,6 compared with the standard 3-dose (3D) schedule (M0,1,6). Healthy females (age stratified: 9–14, 15–19, 20–25 years) were randomized to receive 2D at M0,6 (n = 240) or 3D at M0,1,6 (n = 239). In the according-to-protocol immunogenicity cohort, all initially seronegative subjects seroconverted for HPV-16 and -18 antibodies and remained seropositive up to M48. For both HPV-16 and -18, geometric mean antibody titer (GMT) ratios (3D schedule in women aged 15–25 years divided by 2D schedule in girls aged 9–14 years) at M36 and M48 were close to 1, as they were at M7 when non-inferiority was demonstrated. The kinetics of HPV-16, -18, -31, and -45 antibody responses were similar for both groups and HPV-16 and -18 GMTs were substantially higher than natural infection titers. The vaccine had a clinically acceptable safety profile in both groups. In summary, antibody responses to a 2D M0,6 schedule of the licensed vaccine formulation in girls aged 9–14 years appeared comparable to the standard 3D schedule in women aged 15–25 years up to 4 years after first vaccination. A 2D schedule could facilitate implementation of HPV vaccination programs and improve vaccine coverage and series completion rates. PMID:24576907

  13. Risk of Future Diabetes in Japanese People with High-normal Fasting Plasma Glucose Levels: A 4-Year Follow-up Study.

    PubMed

    Watanabe, Yoh; Eto, Tanenao; Taniguchi, Shotaro; Terauchi, Yasuo

    2016-01-01

    Objective There is no definite consensus regarding the treatment and guidance for individuals with high-normal fasting plasma glucose levels (FPG;100-109 mg/dL). The present study aimed to determine the risk factors for future diabetes in Japanese people with high-normal FPG. Methods Retrospective cohort studies were conducted from 2008 to 2012, including 15,097 individuals who underwent medical examinations. First, the participants were divided into normal FPG (n=13,065) and high-normal FPG (n=2,032) groups to compare the diabetes incidence. Second, the high FPG group was divided into diabetes onset (n=133) and non-diabetes onset (n=1,899) groups to compare the baseline values. Third, to determine the risk factors for future diabetes in the high-normal FPG group, multivariate analyses were conducted. Results The cumulative incidence during the mean follow-up of 4 years was 94/13,065 (0.72%) and 133/2,032 (6.55%) in the normal FPG and high-normal FPG groups, respectively. Within the high-normal FPG group, the baseline body mass index, waist circumference, triglycerides, FPG, alanine aminotransferase (ALT), and gamma-glutamyl transferase were significantly higher and high-density lipoprotein cholesterol (HDL-C) was significantly lower in the diabetes onset group than in the non-diabetes onset group. Obesity, abdominal obesity, hypertriglyceridemia, low HDL-C, and high ALT were significant risk factors for diabetes according to a multivariate analysis. Conclusion The high-normal FPG group had a higher risk of diabetes than the normal FPG group, particularly when accompanied with obesity, abdominal obesity, hypertriglyceridemia, low HDL-C, and high ALT. Thus, this high risk group should receive appropriate guidance for lifestyle changes to avoid developing diabetes at an early stage. PMID:27580535

  14. Rosiglitazone Decreases C-Reactive Protein to a Greater Extent Relative to Glyburide and Metformin Over 4 Years Despite Greater Weight Gain

    PubMed Central

    Kahn, Steven E.; Haffner, Steven M.; Viberti, Giancarlo; Herman, William H.; Lachin, John M.; Kravitz, Barbara G.; Yu, Dahong; Paul, Gitanjali; Holman, Rury R.; Zinman, Bernard

    2010-01-01

    OBJECTIVE C-reactive protein (CRP) is closely associated with obesity and cardiovascular disease in both diabetic and nondiabetic populations. In the short term, commonly prescribed antidiabetic agents have different effects on CRP; however, the long-term effects of those agents are unknown. RESEARCH DESIGN AND METHODS In A Diabetes Outcome Progression Trial (ADOPT), we examined the long-term effects of rosiglitazone, glyburide, and metformin on CRP and the relationship among CRP, weight, and glycemic variables in 904 subjects over 4 years. RESULTS Baseline CRP was significantly correlated with homeostasis model assessment of insulin resistance (HOMA-IR), A1C, BMI, waist circumference, and waist-to-hip ratio. CRP reduction was greater in the rosiglitazone group by −47.6% relative to glyburide and by −30.5% relative to metformin at 48 months. Mean weight gain from baseline (at 48 months) was 5.6 kg with rosiglitazone, 1.8 kg with glyburide, and −2.8 kg with metformin. The change in CRP from baseline to 12 months was correlated positively with change in BMI in glyburide (r = 0.18) and metformin (r = 0.20) groups but not in the rosiglitazone (r = −0.05, NS) group. However, there was no longer a significant correlation between change in CRP and change in HOMA-IR, A1C, or waist-to-hip ratio in any of the three treatment groups. CONCLUSIONS Rosiglitazone treatment was associated with durable reductions in CRP independent of changes in insulin sensitivity, A1C, and weight gain. CRP in the glyburide and metformin groups was positively associated with changes in weight, but this was not the case with rosiglitazone. PMID:19808911

  15. Poverty as a Predictor of 4-Year-Olds' Executive Function: New Perspectives on Models of Differential Susceptibility

    ERIC Educational Resources Information Center

    Raver, C. Cybele; Blair, Clancy; Willoughby, Michael

    2013-01-01

    In a predominantly low-income, population-based longitudinal sample of 1,259 children followed from birth, results suggest that chronic exposure to poverty and the strains of financial hardship were each uniquely predictive of young children's performance on measures of executive functioning. Results suggest that temperament-based vulnerability…

  16. Radiostrontium levels in foodstuffs: 4-Years control activity by Italian reference centre, as a contribution to risk assessment.

    PubMed

    Iammarino, Marco; dell'Oro, Daniela; Bortone, Nicola; Mangiacotti, Michele; Damiano, Rita; Chiaravalle, Antonio Eugenio

    2016-11-01

    (90)Sr is considered an important contaminant relating to food supply chains. In this study, 176 liquid and 260 solid foods, were analysed in order to quantify (90)Sr. Through ruggedness tests, the application field of radiochemical methods used was extended successfully to all most important types of foodstuffs. Regarding liquid matrices, milk samples resulted the most important indicator about (90)Sr contamination, with mean (90)Sr activity concentration equal to 0.058BqL(-1). Among other liquid foods, wine/spirits and livestock watering resulted the most contaminated, with mean contamination levels equal to 0.022 and 0.035BqL(-1), respectively. Concerning solid matrices, cheeses produced from sheep's milk and animal feeds resulted the most contaminated (mean levels: 1.237 and 1.557Bqkg(-1), respectively). Meat products and seafood showed contamination levels not significant within this survey; while, among vegetables, cacao/chocolate and spices resulted in contamination levels comparable with those of cheese obtained from milk of cows origin. PMID:27211657

  17. Support for Alcohol-Control Policies and Enforcement Strategies among US College Students at 4-Year Institutions

    ERIC Educational Resources Information Center

    DeJong, William; Towvim, Laura Gomberg; Schneider, Shari Kessel

    2007-01-01

    Objective: The authors examined college student support for policies and enforcement strategies to reduce alcohol problems on campus. Participants: A random sample of students from each of 32 four-year colleges and universities participated. Methods: Students completed an anonymous mail survey. Results: A majority of students supported 5 of the 12…

  18. The integration of minimally invasive surgery in surgical practice in a Canadian setting: results from 2 consecutive province-wide practice surveys of general surgeons over a 5-year period

    PubMed Central

    Hallet, Julie; Mailloux, Olivier; Chhiv, Mony; Grégoire, Roger C.; Gagné, Jean-Pierre

    2015-01-01

    Background Although minimally invasive surgery (MIS) has been quickly embraced, the introduction of advanced procedures appears more complex. We assessed the evolution of MIS in the province of Quebec over a 5-year period to identify areas for improvement in the modern surgical era. Methods We developed, test-piloted and conducted a self-administered questionnaire among Quebec general surgeons in 2007 and 2012 to examine stated MIS practice, MIS training and barriers and facilitators to the use of MIS. Results Response rates were 51.3% (251 of 489) in 2007 and 31.3% (153 of 491) in 2012. A significant increase was observed for performance of most advanced MIS procedures, especially for colectomy for benign (66.0% v. 84.3%, p < 0,001) and malignant diseases (43.3% v. 77.8%, p < 0,001) and for rectal surgery for malignancy (21.0% v. 54.6%, p < 0.001). More surgeons practised 3 or more advanced MIS procedures in 2012 than in 2007 (82.3% v. 64.3%, p < 0,001). At multivariate analysis, the 2007 survey administration was associated with fewer surgeons practising advanced MIS (odds ratio 0.13, 95% confidence interval 0.06–0.29). In 2012, more respondents stated they gained their skills during residency (p = 0.028). Conclusion From 2007 to 2012 there was a significant increase in advanced MIS procedures practised by general surgeons in Québec. This technique appears well established in current surgical practice. The growing place of MIS in residency training seems to be a paramount part of this development. Results from this study could be used as a baseline for studies focusing on ways to further improve the MIS practice. PMID:25598180

  19. Coincident 1.3-year Periodicities in the ap Geomagnetic Index and the Solar Wind

    NASA Technical Reports Server (NTRS)

    Paularena, K. I.; Szabo, A.; Richardson, J. D.

    1995-01-01

    Recent observations show an approximately 1.3-year period in the speed of the solar wind detected by the IMP 8 and Voyager 2 spacecraft. A similar period is also seen in the north-south (GSE) component of the magnetic field observed by IMP 8. Since both parameters are commonly used as input to models of geomagnetic activity, the 'ap' index (a measure of geomagnetic disturbance) is examined to look for this periodicity. The Lomb-Scargle periodogram method is used on the ap, plasma, and magnetic field data during the 1973-1994 time range. A dynamic FFT periodogram method is also used to analyze the ap data during this time, as well as to look for periods present between 1932 and 1972. A clear 1.3-year periodicity is present in the post-1986 data when the same period is observed in the plasma and field data. The V(2)B(zsm) and V(2)B(s) proxies for geomagnetic activity also show this periodicity. However, the southward (GSM) component of the magnetic field does not have a 1.3-year period, and neither do solar wind or ap data from 1973-1985. This demonstrates that the ap geomagnetic index can act as a proxy for solar wind periodicities at this time scale. Historic ap data are examined, and show that a similar periodicity in ap exists around 1942. Since auroral data show a 1.4-year periodicity, all these similar periods may result from a common underlying solar mechanism.

  20. Astrophysical implications of periodicity

    NASA Technical Reports Server (NTRS)

    Muller, Richard A.

    1988-01-01

    Two remarkable discoveries of the last decade have profound implications for astrophysics and for geophysics. These are the discovery by Alvarez et al., that certain mass extinctions are caused by the impact on the earth of a large asteroid or comet, and the discovery by Raup and Sepkoski that such extinctions are periodic, with a cycle time of 26 to 30 million years. The validity of both of these discoveries is assumed and the implications are examined. Most of the phenomena described depend not on periodicity, but just on the weaker assumption that the impacts on the earth take place primarily in showers. Proposed explanations for the periodicity include galactic oscillations, the Planet X model, and the possibility of Nemesis, a solar companion star. These hypotheses are critically examined. Results of the search for the solar companion are reported. The Deccan flood basalts of India have been proposed as the impact site for the Cretaceous impact, but this hypotheisis is in contradiction with the conclusion of Courtillot et al., that the magma flow began during a period of normal magnetic field. A possible resolution of this contradiction is proposed.

  1. Oscillations following periodic reinforcement.

    PubMed

    Monteiro, Tiago; Machado, Armando

    2009-06-01

    Three experiments examined behavior in extinction following periodic reinforcement. During the first phase of Experiment 1, four groups of pigeons were exposed to fixed interval (FI 16s or FI 48s) or variable interval (VI 16s or VI 48s) reinforcement schedules. Next, during the second phase, each session started with reinforcement trials and ended with an extinction segment. Experiment 2 was similar except that the extinction segment was considerably longer. Experiment 3 replaced the FI schedules with a peak procedure, with FI trials interspersed with non-food peak interval (PI) trials that were four times longer. One group of pigeons was exposed to FI 20s PI 80s trials, and another to FI 40s PI 160s trials. Results showed that, during the extinction segment, most pigeons trained with FI schedules, but not with VI schedules, displayed pause-peck oscillations with a period close to, but slightly greater than the FI parameter. These oscillations did not start immediately after the onset of extinction. Comparing the oscillations from Experiments 1 and 2 suggested that the alternation of reconditioning and re-extinction increases the reliability and earlier onset of the oscillations. In Experiment 3 the pigeons exhibited well-defined pause-peck cycles since the onset of extinction. These cycles had periods close to twice the value of the FI and lasted for long intervals of time. We discuss some hypotheses concerning the processes underlying behavioral oscillations following periodic reinforcement. PMID:18992793

  2. Micro-Bypass Implantation for Primary Open-Angle Glaucoma Combined with Phacoemulsification: 4-Year Follow-Up

    PubMed Central

    Fea, Antonio Maria; Consolandi, Giulia; Zola, Marta; Pignata, Giulia; Cannizzo, Paola; Lavia, Carlo; Rolle, Teresa; Grignolo, Federico Maria

    2015-01-01

    Purpose. To report the long-term follow-up results in patients with cataract and primary open-angle glaucoma (POAG) randomly assigned to cataract surgery combined with micro-bypass stent implantation or phacoemulsification alone. Methods. 36 subjects with cataract and POAG were randomized in a 1 : 2 ratio to either iStent implantation and cataract surgery (combined group) or cataract surgery alone (control group). 24 subjects agreed to be evaluated again 48 months after surgery. Patients returned one month later for unmedicated washout assessment. Results. At the long-term follow-up visit we reported a mean IOP of 15,9 ± 2,3 mmHg in the iStent group and 17 ± 2,5 mmHg in the control group (p = NS). After washout, a 14,2% between group difference in favour of the combined group was statistically significant (p = 0,02) for mean IOP reduction. A significant reduction in the mean number of medications was observed in both groups compared to baseline values (p = 0,005 in the combined group and p = 0,01 in the control group). Conclusion. Patients in the combined group maintained low IOP levels after long-term follow-up. Cataract surgery alone showed a loss of efficacy in controlling IOP over time. Both treatments reduced the number of ocular hypotensive medications prescribed. This trial is registered with: NCT00847158. PMID:26587282

  3. Complete mouth reconstruction with implant-supported fixed partial dental prostheses fabricated with zirconia frameworks: a 4-year clinical follow-up.

    PubMed

    Puri, Shweta; Parciak, Ewa C; Kattadiyil, Mathew T

    2014-09-01

    Few scientific reports regarding the success of complete mouth partial fixed dental prostheses frameworks fabricated with zirconia are available, especially when dental implants serve as the abutments. A complete mouth reconstruction with zirconia frameworks veneered with feldspathic porcelain is reported involving a 65-year-old white woman who presented with partial edentulism and an unrestorable remaining dentition. After examination, 14 implants were planned (8 in the maxillary arch and 6 in the mandibular arch), and implant-supported zirconia framework screw-retained partial fixed dental prostheses (ISZPFDPs) were fabricated and made in sections for easier retrievability and management. No major complications were encountered during follow-up appointments at 6-month intervals for 4 years. However, minor fractures of the veneering ceramic were noted 4 years after placement. The ISZPFDPs were well accepted by the patient and had a favorable outcome in terms of patient acceptability and success, despite some complications. PMID:24674806

  4. Use of an Intrapericardial Continuous Flow Ventricular Assist Device in a 4-Year-Old Child Weighing 12 Kilograms.

    PubMed

    Erkanlı, Korhan; Kaya, Mehmet; Avşar, Murat; Bakır, İhsan

    2016-01-01

    Ventricular assist devices are implanted in patients with intractable heart failure as a bridge to cardiac transplantation to support the circulatory system mechanically. We present a report of a continuous flow ventricular assist device successfully placed as a bridge to transplantation in the intrapericardium of a petite-sized child with a BSA of 0.56 m2. Not only is the use of an intrapericardial, continuous-flow, centrifugal pump feasible for destination therapy, but also for low-weight pediatric patients with end-stage heart failure as a bridge to transplantation when there is chronic shortage of donor organs for heart transplantation. Consequently, the HeartWare system has been implanted in smaller patients with acceptable results, and this patient may be the youngest ever reported. PMID:27146239

  5. Positive periodic solutions of delayed periodic Lotka-Volterra systems

    NASA Astrophysics Data System (ADS)

    Lin, Wei; Chen, Tianping

    2005-01-01

    In this Letter, for a general class of delayed periodic Lotka-Volterra systems, we prove some new results on the existence of positive periodic solutions by Schauder's fixed point theorem. The global asymptotical stability of positive periodic solutions is discussed further, and conditions for exponential convergence are given. The conditions we obtained are weaker than the previously known ones and can be easily reduced to several special cases.

  6. Trends in paediatric rheumatology referral times and disease activity indices over a ten-year period among children and young people with Juvenile Idiopathic Arthritis: results from the childhood arthritis prospective Study

    PubMed Central

    McErlane, Flora; Foster, Helen E.; Carrasco, Roberto; Baildam, Eileen M.; Chieng, S. E. Alice; Davidson, Joyce E.; Ioannou, Yiannis; Wedderburn, Lucy R.; Thomson, Wendy

    2016-01-01

    Objectives. The medical management of JIA has advanced significantly over the past 10 years. It is not known whether these changes have impacted on outcomes. The aim of this analysis was to identify and describe trends in referral times, treatment times and 1-year outcomes over a 10-year period among children with JIA enrolled in the Childhood Arthritis Prospective Study. Methods. The Childhood Arthritis Prospective Study is a prospective inception cohort of children with new-onset inflammatory arthritis. Analysis included all children recruited in 2001–11 with at least 1 year of follow-up, divided into four groups by year of diagnosis. Median referral time, baseline disease pattern (oligoarticular, polyarticular or systemic onset) and time to first definitive treatment were compared between groups. Where possible, clinical juvenile arthritis disease activity score (cJADAS) cut-offs were applied at 1 year. Results. One thousand and sixty-six children were included in the analysis. The median time from symptom onset and referral to first paediatric rheumatology appointment (22.7–24.7 and 3.4–4.7 weeks, respectively) did not vary significantly (∼20% seen within 10 weeks of onset and ∼50% within 4 weeks of referral). For oligoarticular and polyarticular disease, 33.8–47 and 25.4–34.9%, respectively, achieved inactive disease by 1 year, with ∼30% in high disease activity at 1 year. A positive trend towards earlier definitive treatment reached significance in oligoarticular and polyarticular pattern disease. Conclusion. Children with new-onset JIA have a persistent delay in access to paediatric rheumatology care, with one-third in high disease activity at 1 year and no significant improvement over the past 10 years. Contributing factors may include service pressures and poor awareness. Further research is necessary to gain a better understanding and improve important clinical outcomes. PMID:27016664

  7. Use of a Rapid Ethylene Glycol Assay: a 4-Year Retrospective Study at an Academic Medical Center.

    PubMed

    Rooney, Sydney L; Ehlers, Alexandra; Morris, Cory; Drees, Denny; Davis, Scott R; Kulhavy, Jeff; Krasowski, Matthew D

    2016-06-01

    Ethylene glycol (EG) is a common cause of toxic ingestions. Gas chromatography (GC)-based laboratory assays are the gold standard for diagnosing EG intoxication. However, GC requires specialized instrumentation and technical expertise that limits feasibility for many clinical laboratories. The objective of this retrospective study was to determine the utility of incorporating a rapid EG assay for management of cases with suspected EG poisoning. The University of Iowa Hospitals and Clinics core clinical laboratory adapted a veterinary EG assay (Catachem, Inc.) for the Roche Diagnostics cobas 8000 c502 analyzer and incorporated this assay in an osmolal gap-based algorithm for potential toxic alcohol/glycol ingestions. The main limitation is that high concentrations of propylene glycol (PG), while readily identifiable by reaction rate kinetics, can interfere with EG measurement. The clinical laboratory had the ability to perform GC for EG and PG, if needed. A total of 222 rapid EG and 24 EG/PG GC analyses were documented in 106 patient encounters. Of ten confirmed EG ingestions, eight cases were managed entirely with the rapid EG assay. PG interference was evident in 25 samples, leading to 8 GC analyses to rule out the presence of EG. Chart review of cases with negative rapid EG assay results showed no evidence of false negatives. The results of this study highlight the use of incorporating a rapid EG assay for the diagnosis and management of suspected EG toxicity by decreasing the reliance on GC. Future improvements would involve rapid EG assays that completely avoid interference by PG. PMID:26553280

  8. Exploring the Academic and Social Experiences of Latino Engineering Community College Transfer Students at a 4-Year Institution: A Qualitative Research Study

    NASA Astrophysics Data System (ADS)

    Hagler, LaTesha R.

    As the number of historically underrepresented populations transfer from community college to university to pursue baccalaureate degrees in science, technology, engineering, and mathematics (STEM), little research exists about the challenges and successes Latino students experience as they transition from 2-year colleges to 4-year universities. Thus, institutions of higher education have limited insight to inform their policies, practices, and strategic planning in developing effective sources of support, services, and programs for underrepresented students in STEM disciplines. This qualitative research study explored the academic and social experiences of 14 Latino engineering community college transfer students at one university. Specifically, this study examined the lived experiences of minority community college transfer students' transition into and persistence at a 4-year institution. The conceptual framework applied to this study was Schlossberg's Transition Theory, which analyzed the participant's social and academic experiences that led to their successful transition from community college to university. Three themes emerged from the narrative data analysis: (a) Academic Experiences, (b) Social Experiences, and (c) Sources of Support. The findings indicate that engineering community college transfer students experience many challenges in their transition into and persistence at 4-year institutions. Some of the challenges include lack of academic preparedness, environmental challenges, lack of time management skills and faculty serving the role as institutional agents.

  9. Periodate oxidation of dextrans

    SciTech Connect

    Mirgorodskaya, O.A.; Poletaeva, L.V.

    1986-03-01

    The authors estimate the degree of oxidation of the thiol group in dextran with various mol. wt. and make an attempt at a kinetic description of the main parameters of the process. Polyglucin was used. The results are shown of experiments done on the estimation of the amount of products formed in the process of oxidation of polyglucin in which the reaction stopped as a result of complete exhaustion of one of the original reagents. To estimate the reactivity of the thiol group toward oxidation, the authors studied the interaction of potassium periodate with alpha-D-glucose, isolated by the monomer unit of dextran.

  10. Clostridium Difficile Infection in Hospitalized Patients at University Clinical Center Tuzla, Bosnia and Herzegovina: a 4 Year Experience

    PubMed Central

    Ahmetagic, Sead; Salkic, Nermin; Ahmetagic, Aldina; Custovic, Amer; Tihic, Nijaz; Smajlovic, Jasmina; Porobic-Jahic, Humera

    2013-01-01

    Introduction: Clostridium difficile (C. difficile) is currently the leading cause of healthcare-associated diarrhea, but almost nothing is known about the extent of C. difficile infection (CDI) in Bosnia and Herzegovina. Goal: We aimed to retrospectively analyze CDI in hospitalized patients at University Clinical Center (UCC) Tuzla, Bosnia and Herzegovina from January 2009 through June 2012. Methods: We analyzed all patients (except children ages 0-2), diagnosed with CDI based on anamnestic and epidemiological, clinical picture and microbiological tests (proof of toxins in the stool by enzyme-linked immunosorbent assay). Results: From a total of 989 patients tested for C. difficile toxin (60.2 per 10,000 inpatient days) 347 (35.08%) were positives. The mean incidence rate of CDI was 2.23 per 10,000 inpatient days (range 1.32-2.87). Annual rates of hospitalization were 15.68 per 10,000 admissions (range 8.99-20.35). Most patients had a previously identified risk profile of old age, comorbidity and recent use of antibiotics. 41/276 (14.86%) patients had died, and 11/41 (26.82%) were CDI-associated deaths. Complicated CDI were registered in 53/276 (19.21%) patients, and recurrent infections in 65/276 (23.55%). Conclusion: Our data suggest that CDI is largely present in our setting which represents a serious problem and points to the importance of international surveillance, detection and control of CDI. PMID:24167425

  11. College Health Surveillance Network: Epidemiology and Health Care Utilization of College Students at US 4-Year Universities

    PubMed Central

    Turner, James C.; Keller, Adrienne

    2015-01-01

    Abstract Objective: This description of the College Health Surveillance Network (CHSN) includes methodology, demography, epidemiology, and health care utilization. Participants: Twenty-three universities representing approximately 730,000 enrolled students contributed data from January 1, 2011, through May 31, 2014. Methods: Participating schools uploaded de-identified electronic health records from student health services monthly. Results: During this study, just over 800,000 individuals used the health centers, comprising 4.17 million patient encounters. Sixty percent of visits included primary care, 13% mental health, 9% vaccination, and 31% other miscellaneous services. The 5 most common specific diagnostic categories (with annual rates per 100 enrolled students) were preventive (16); respiratory (12); skin, hair, and nails; infectious non–sexually transmitted infection (5 each); and mental health (4). Utilization and epidemiologic trends are identified among subpopulations of students. Conclusions: CHSN data establish trends in utilization and epidemiologic patterns by college students and the importance of primary and behavioral health care services on campuses. PMID:26086428

  12. Limits on dark matter annihilation signals from the Fermi LAT 4-year measurement of the isotropic gamma-ray background

    DOE PAGESBeta

    Ackermann, M.

    2015-09-02

    We search for evidence of dark matter (DM) annihilation in the isotropic gamma-ray background (IGRB) measured with 50 months of Fermi Large Area Telescope (LAT) observations. An improved theoretical description of the cosmological DM annihilation signal, based on two complementary techniques and assuming generic weakly interacting massive particle (WIMP) properties, renders more precise predictions compared to previous work. More specifically, we estimate the cosmologically-induced gamma-ray intensity to have an uncertainty of a factor ~ 20 in canonical setups. We consistently include both the Galactic and extragalactic signals under the same theoretical framework, and study the impact of the former onmore » the IGRB spectrum derivation. We find no evidence for a DM signal and we set limits on the DM-induced isotropic gamma-ray signal. Our limits are competitive for DM particle masses up to tens of TeV and, indeed, are the strongest limits derived from Fermi LAT data at TeV energies. This is possible thanks to the new Fermi LAT IGRB measurement, which now extends up to an energy of 820 GeV. As a result, we quantify uncertainties in detail and show the potential this type of search offers for testing the WIMP paradigm with a complementary and truly cosmological probe of DM particle signals.« less

  13. Limits on dark matter annihilation signals from the Fermi LAT 4-year measurement of the isotropic gamma-ray background

    SciTech Connect

    Ackermann, M.

    2015-09-02

    We search for evidence of dark matter (DM) annihilation in the isotropic gamma-ray background (IGRB) measured with 50 months of Fermi Large Area Telescope (LAT) observations. An improved theoretical description of the cosmological DM annihilation signal, based on two complementary techniques and assuming generic weakly interacting massive particle (WIMP) properties, renders more precise predictions compared to previous work. More specifically, we estimate the cosmologically-induced gamma-ray intensity to have an uncertainty of a factor ~ 20 in canonical setups. We consistently include both the Galactic and extragalactic signals under the same theoretical framework, and study the impact of the former on the IGRB spectrum derivation. We find no evidence for a DM signal and we set limits on the DM-induced isotropic gamma-ray signal. Our limits are competitive for DM particle masses up to tens of TeV and, indeed, are the strongest limits derived from Fermi LAT data at TeV energies. This is possible thanks to the new Fermi LAT IGRB measurement, which now extends up to an energy of 820 GeV. As a result, we quantify uncertainties in detail and show the potential this type of search offers for testing the WIMP paradigm with a complementary and truly cosmological probe of DM particle signals.

  14. Cells anticipate periodic events

    NASA Astrophysics Data System (ADS)

    Nakagaki, Toshiyuki

    2009-03-01

    We show that an amoeboid organism can anticipate the timing of periodic events. The plasmodium of the true slime mold Physarum polycephalum moves rapidly under favourable conditions, but stops moving when transferred to less-favourable conditions. Plasmodia exposed to unfavourable conditions, presented in three consecutive pulses at constant intervals, reduced their locomotive speed in response to each episode. When subsequently subjected to favourable conditions, the plasmodia spontaneously reduced their locomotive speed at the time point when the next unfavourable episode would have occurred. This implied anticipation of impending environmental change. After this behaviour had been evoked several times, the locomotion of the plasmodia returned to normal; however, the anticipatory response could subsequently be induced by a single unfavourable pulse, implying recall of the memorized periodicity. We explored the mechanisms underlying these behaviours from a dynamical systems perspective. Our results hint at the cellular origins of primitive intelligence and imply that simple dynamics might be sufficient to explain its emergence.

  15. Hot executive function following moderate-to-late preterm birth: altered delay discounting at 4 years of age.

    PubMed

    Hodel, Amanda S; Brumbaugh, Jane E; Morris, Alyssa R; Thomas, Kathleen M

    2016-03-01

    Interest in monitoring long-term neurodevelopmental outcomes of children born moderate-to-late preterm (32-36 weeks gestation) is increasing. Moderate-to-late preterm birth has a negative impact on academic achievement, which may relate to differential development of executive function (EF). Prior studies reporting deficits in EF in preterm children have almost exclusively assessed EF in affectively neutral contexts in high-risk preterm children (< 32 weeks gestation). Disrupted function in motivational or emotionally charged contexts (hot EF) following preterm birth remains uninvestigated, despite evidence that preterm children show differential development of neural circuitry subserving hot EF, including reduced orbitofrontal cortex volume. The present study is the first to examine whether low-risk, healthy children born moderate-to-late preterm exhibit impairments in the development of hot EF. Preterm children at age 4.5 years were less likely to choose larger, delayed rewards across all levels of reward magnitude on a delay discounting task using tangible rewards, but performed more similarly to their full-term peers on a delay aversion task involving abstract rewards and on measures of cool EF. The relationship between gestational age at birth and selection of delayed rewards extended across the entire gestational age range of the sample (32-42 weeks), and remained significant after controlling for intelligence and processing speed. Results imply that there is not a finite cut-off point at which children are spared from potential long-term neurodevelopmental effects of PT birth. Further investigation of reward processing and hot EF in individuals with a history of PT birth is warranted given the susceptibility of prefrontal cortex development to early environmental variations. PMID:25873181

  16. Sugar Sweetened Beverages and Weight Gain over 4 Years in a Thai National Cohort – A Prospective Analysis

    PubMed Central

    Lim, Lynette; Banwell, Cathy; Bain, Chris; Banks, Emily; Seubsman, Sam-ang; Kelly, Matthew; Yiengprugsawan, Vasoontara; Sleigh, Adrian

    2014-01-01

    Introduction Sugar sweetened beverages (SSBs) are implicated in the rising prevalence of obesity and diet-related chronic diseases worldwide. However, little is known about their contribution to weight gain in Asian populations. This study aimed to investigate weight change associated with SSB consumption between 2005 and 2009 in a large national cohort of Thai university students. Methods Questionnaire data were collected from a large Thai cohort (the Thai Health-Risk Transition: a National Cohort Study). The analysis was based on responses from 59 283 of the 60 569 (98%) cohort members who had valid SSB consumption and weight variables in 2005 and 2009. The relationship between SSB consumption in 2005 and self-reported weight change was analysed using multiple linear regression models controlled for socio-demographic, activity and (non-validated) dietary factors shown to influence weight. Results Higher frequency of SSB consumption in 2005 was significantly associated with greater weight gain between 2005 and 2009 in all age groups and in both sexes (p<0.0001); persons who consumed SSBs at least once a day in 2005 gained 0.5 kg more than those who consumed SSBs less than once a month. The estimated weight gain for the average person in the sample was 1.9 kg (95% C I 1.95–1.96). The difference in weight gain between those who increased their consumption frequency ( once per day) between 2005 and 2009 compared to those who maintained it was 0.3 kgs, while persons who reduced their consumption frequency (once a day to > once a month) gained 0.2 kgs less than those whose consumption remained unchanged. Conclusion SSB consumption is independently associated with weight gain in the Thai population. Research and health promotion in Thailand and other economically transitioning countries should focus on reducing their contribution to population weight gain and to diet-related chronic diseases. PMID:24805125

  17. A comparison of proficiency levels in 4-year-old monolingual and trilingual speakers of Afrikaans, isiXhosa and South African English across SES boundaries, using LITMUS-CLT.

    PubMed

    Perold Potgieter, Anneke; Southwood, Frenette

    2016-01-01

    This study investigated how trilinguals fare on the cross-linguistic lexical tasks (CLT)-Afrikaans, -isiXhosa and -South African English (SAE) (cf. Haman et al., 2015) compared to monolingual controls, and whether the CLT-Afrikaans renders comparable results across socioeconomic status (SES) backgrounds. The LITMUS-CLTs were administered to 41 low SES 4-year-olds (11 trilinguals; 10 monolingual speakers of Afrikaans, isiXhosa and SAE) and the LITMUS-CLT-Afrikaans to 11 mid-SES 4-year-old monolinguals. Results (a) indicate that trilinguals' proficiency in their exposure-dominant language did not differ significantly from monolinguals' proficiency, but their proficiency in their additional two languages was significantly lower than monolinguals' proficiency; (b) reflect the extent, but not current amount, of exposure trilinguals had had over time to each of their languages; and (c) show that low and mid-SES monolinguals differed significantly on noun-related, but not verb-related, CLT measures. Possible reasons for and the clinical implications of these results are discussed. PMID:26785940

  18. Familial Periodic Paralyses

    MedlinePlus

    ... NINDS NINDS Familial Periodic Paralyses Information Page Synonym(s): Periodic Paralyses Table of Contents (click to jump to sections) What are Familial Periodic Paralyses? Is there any treatment? What is the ...

  19. Middle school students' attitudes toward math and STEM career interests: A 4-year follow-up study

    NASA Astrophysics Data System (ADS)

    Schneider, Madalyn R.

    /careers with a medium effect. Results supported a 2-factor model of Attitudes toward Mathematics consisting of Math Self-Concept and Attitudes toward Assistments. Other significant findings include: a positive relationship between students' Attitudes toward Assistments and level of math class taken in high school; a positive relationship between students' Math Self-Concept and Self Control; a positive relationship between Self Control and students' endorsement of STEM careers while in middle school, and discrepancy between male and female students' endorsement of STEM careers as early as middle school. Although many of the study's primary hypotheses were not supported, the present study provides a framework and baseline for several important considerations. Limitations, including those related to the present study's small sample size, and future implications of the present study, which add to career development literature in STEM, are discussed in regard to both research and practice. Keywords: career development, middle school, attitudes, math, STEM, self-concept

  20. Impact of 4-year CO2 injection on reservoir-rock integrity at the CO2 pilot site Ketzin (Germany)

    NASA Astrophysics Data System (ADS)

    Bock, S.; Förster, H.; Meier, A.; Pudlo, D.; Förster, A.; Gaupp, R.

    2013-12-01

    The CO2 Ketzin pilot site offers the possibility to study the short-term effects of injected CO2 on the mineralogy, geochemistry and porosity/permeability of siliciclastic reservoir rocks in a saline aquifer. Ketzin is located 30 kilometers west of Berlin in the Northeast German Basin, a sedimentary basin containing Paleozoic to Cenozoic sediments. The site is characterized by an anticlinal structure formed through halokinetic uprise of Permian salt. The reservoir in the Upper Triassic Stuttgart Formation, in which about 64,000 tons of CO2 are stored at depth of 630-700 m, is heterogeneous, comprising sandstones and siltstones. The Stuttgart Formation is overlain by a 200-m-thick caprock system of massive mudstones pertaining to the Upper Triassic Weser Formation and Arnstadt Formation. Argillaceous Tertiary sediments form an additional caprock in the shallow subsurface. Core material was recovered in 2007 for a baseline study and again in August 2012, almost four years after start of CO2 injection, to evaluate the fluid-rock reactions that took place. Preliminary results of an ongoing study, which focuses on petrographic-mineralogical and geochemical features, reveal negligible changes in bulk-rock composition almost in the range of the pristine natural heterogeneity of the reservoir. No significant dissolution or precipitation of minerals occurred implying that CO2 was trapped mainly structurally and residually as well as became dissolved in the formation brine. Additional studies concentrated on the fixation of CO2 by mineral trapping. Analytical work was focused on small-scale variations and reactions within and on the surface of minerals. X-ray Photoelectron Spectroscopy (XPS) supplied information about the alteration of Fe-rich grain coatings. This surface-sensitive method provides, beyond the quantitative analysis of certain elements, information on the valence state and quantity of iron. A weak tendency of transformation from hematite to goethite coatings

  1. Seasonal 4-year investigation into the role of the alpine marmot (Marmota marmota) as a carrier of zoophilic dermatophytes.

    PubMed

    Gallo, M G; Lanfranchi, P; Poglayen, G; Calderola, S; Menzano, A; Ferroglio, E; Peano, A

    2005-06-01

    Two hundred and six samples of alpine marmot (Mamota marmota) hair (148 from adults and 58 from young subjects), 102 soil samples from the entrances to the burrows of the above individuals and 20 control specimens (obtained from adjoining areas away from the burrow systems where the rodents are not usually present) were examined from May 1994 to September 1997. Seventy-five isolates belonging to six species of dermatophytes were found in 69 of the 206 hair samples examined (33.5%). Two species were zoophilic, Microsporum canis (7.8%) and Trichophyton mentagrophytes (11.2.%), and four geophilic, Microsporum cookei (2%), M. gypseum (5.8%), Trichophyton ajelloi (3.9%) and T. terrestre (5.8%). The prevalence of each species in the hair samples did not change significantly according to year, season (chi-squared test [limit significance: P <0.05] gives no significant values [P>0.05] both in year and in season comparison) or age/sex (adult versus juvenile: P=0.1; male versus female: P=0.8) of the marmot. Twenty-three of the 102 soil samples (22.5%) were positive for dermatophytes found in the hair of marmots from the same burrow systems. Five of the 20 control soil samples (25%) were positive for dermatophytes. One isolate of M. gypseum, three of T. terrestre and one of T. mentagrophytes were obtained. Compared with other free-ranging rodent hosts studied in Europe, this mycoflora is characterized by the presence and relatively high prevalence of M. canis, frequently reported in symptomatic and asymptomatic cats, dogs and fur animals. M. canis has not been isolated in other rodents in the wild. However, it has recently been reported in asymptomatic foxes (Vulpes vulpes) from northern Italy. The close link between V vulpes and M. marmota, with the former representing the most important mammal predator of the latter in the Alps (only a fraction of the predator's attacks result in the death of the rodent) may have favoured the adaptation of M. canis to this rodent host. The

  2. Mechanisms of grass response in grasslands and shrublands during dry or wet periods.

    PubMed

    Peters, Debra P C; Yao, Jin; Browning, Dawn; Rango, Albert

    2014-04-01

    Multi-year climatic periods are expected to increase with global change, yet long-term data are often insufficient to document factors leading to ecological responses. We used a suite of long-term datasets (1993-2010) to examine the processes underlying different relationships between aboveground net primary production (ANPP) and precipitation in wet and dry rainfall periods in shrublands and grasslands in the Chihuahuan Desert. We hypothesized that trends in ANPP can be explained by different processes associated with their dominant grasses [Bouteloua eriopoda (grasslands); Sporobolus flexuosus (shrublands)] and with ecosystem properties that influence soil water dynamics with feedbacks to ANPP. We compared datasets on recruitment and growth for 7 years with no trend in precipitation followed by a 4-year drought and 5 consecutive wet years. We integrated these data in a simulation model to examine the importance of positive feedbacks. In grasslands, ANPP was linearly related to precipitation regardless of rainfall period, primarily as a result of stolon recruitment by B. eriopoda. A lag in responses suggests the importance of legacies associated with stolon density. In shrublands, ANPP was only related to rainfall in the wet period when it increased nonlinearly as the number of wet years increased. Seed availability increased in the first wet year, and seedling establishment occurred 2-4 years later. Increases in biomass, litter and simulated transpiration beginning in the third year corresponded with increases in ANPP. Understanding the processes underlying ecosystem dynamics in multi-year dry or wet periods is expected to improve predictions under directional increases or decreases in rainfall. PMID:24263235

  3. Developmental milestones record - 4 years

    MedlinePlus

    ... little differently. If you are concerned about your child's development, talk to your child's health care provider. PHYSICAL ... A.M. Editorial team. Related MedlinePlus Health Topics Child Development Browse the Encyclopedia A.D.A.M., Inc. ...

  4. THE COLOR-PERIOD DIAGRAM AND STELLAR ROTATIONAL EVOLUTION-NEW ROTATION PERIOD MEASUREMENTS IN THE OPEN CLUSTER M34

    SciTech Connect

    Meibom, Soeren; Saar, Steven H.; Mathieu, Robert D.; Stassun, Keivan G.; Liebesny, Paul

    2011-06-01

    We present the results of a 5 month photometric time-series survey for stellar rotation periods combined with a 4 year radial-velocity survey for membership and binarity in the 220 Myr open cluster M34. We report surface rotation periods for 120 stars, 83 of which are kinematic and photometric late-type cluster members. A comparison to previous work serves to illustrate the importance of high-cadence long baseline photometric observations and membership information. The new M34 periods are less biased against slow rotation and cleaned for non-members. The rotation periods of the cluster members span over more than an order of magnitude from 0.5 days up to 11.5 days, and trace two distinct rotational sequences-fast (C) and moderate-to-slow (I)-in the color-period diagram. The sequences represent two different states (fast and slow) in the rotational evolution of the late-type cluster members. We use the color-period diagrams for M34 and for younger and older clusters to estimate the timescale for the transition from the C to the I sequence and find {approx}<150 Myr, {approx}150-300 Myr, and {approx}300-600 Myr for G, early-mid K, and late K dwarfs, respectively. The small number of stars in the gap between C and I suggests a quick transition. We estimate a lower limit on the maximum spin-down rate (dP/dt) during this transition to be {approx}0.06 days Myr{sup -1} and {approx}0.08 days Myr{sup -1} for early and late K dwarfs, respectively. We compare the I sequence rotation periods in M34 and the Hyades for G and K dwarfs and find that K dwarfs spin down slower than the Skumanich {radical}t rate. We determine a gyrochronology age of 240 Myr for M34. The gyro-age has a small formal uncertainty of 2% which reflects the tight I sequence in the M34 color-period diagram. We measure the effect of cluster age uncertainties on the gyrochronology age for M34 and find the resulting error on the gyro-age to be consistent with the {approx}15% error estimate for the technique in

  5. [Preventive-curative dental care in a large East German urban population. The 4-year experiences of a Dresden prevention study with 16- to 35-year-old subjects].

    PubMed

    Klimm, W; Natusch, I; Koch, R; Schreger, E

    1994-01-01

    The present 4-year Dresden preventive study was carried out to realize a dental care concept with preventive emphasis in 6 Dresden state health services. 2502 patients aged 16-35 years were randomly selected in 1988. The effectiveness of this study was evaluated by means of the parameters oral health behaviour, oral health state and preventive care needs. The spectrum of methods included extended anamnesis, plaque index according to Silness & Löe, DMF/T, DMF/S, GPM/T index, CPITN and saliva tests in case of high caries risk. The dental care based on a basic and a risk strategy. The basic strategy included a complex symptomatic dental treatment and a dental prophylaxis, repeated once every 3 month. The patients were given instruction, demonstration, remotivation, professional oral hygiene measures and topical application of fluorides. The 4-year preventive intervention resulted in an improved consultation and oral hygiene behaviour. The nutritional behaviour did not change essentially. Within the cohort plaque index decreased from 1.01 to 0.68, the GPM/T index from 11.7 to 10.4 as well as the preventive care needs. It was found a low caries increment. The care concept with preventive emphasis is recommendable by its effectiveness. PMID:7939548

  6. A 4-year follow-up of two complete mandibular implant-supported removable prostheses in a patient with severe rheumatoid polyarthritis: case report.

    PubMed

    Ella, Bruno; Lasserre, Jean-François; Blanchard, Jean-Pierre; Fricain, Jean Christophe

    2011-01-01

    Rheumatoid polyarthritis is a systemic autoimmune disease characterized by chronic synovitis and bone damage associated with significant functional disability and morbidity. This case report describes a 4-year follow-up of a 56-year-old female receiving polymedication for severe rheumatoid polyarthritis and osteoporosis with a fully edentulous maxilla treated with two osseointegrated implants supporting a removable mandibular prosthesis. No practitioner wanted to use implants to stabilize her mandibular prosthesis because of the health risks involved. This report encourages the dental practitioner to be familiar with the symptoms and oral manifestations of rheumatoid polyarthritis in order to help manage this disease when patients lose all of their teeth. PMID:21483874

  7. Anisotropic diffusion at the field scale in a 4-year multi-tracer diffusion and retention experiment - I: Insights from the experimental data

    NASA Astrophysics Data System (ADS)

    Gimmi, Thomas; Leupin, Olivier X.; Eikenberg, Jost; Glaus, Martin A.; Van Loon, Luc R.; Waber, H. Niklaus; Wersin, Paul; Wang, Hao A. O.; Grolimund, Daniel; Borca, Camelia N.; Dewonck, Sarah; Wittebroodt, Charles

    2014-01-01

    Claystones are considered worldwide as barrier materials for nuclear waste repositories. In the Mont Terri underground research laboratory (URL), a nearly 4-year diffusion and retention (DR) experiment has been performed in Opalinus Clay. It aimed at (1) obtaining data at larger space and time scales than in laboratory experiments and (2) under relevant in situ conditions with respect to pore water chemistry and mechanical stress, (3) quantifying the anisotropy of in situ diffusion, and (4) exploring possible effects of a borehole-disturbed zone. The experiment included two tracer injection intervals in a borehole perpendicular to bedding, through which traced artificial pore water (APW) was circulated, and a pressure monitoring interval. The APW was spiked with neutral tracers (HTO, HDO, H2O-18), anions (Br, I, SeO4), and cations (Na-22, Ba-133, Sr-85, Cs-137, Co-60, Eu-152, stable Cs, and stable Eu). Most tracers were added at the beginning, some were added at a later stage. The hydraulic pressure in the injection intervals was adjusted according to the measured value in the pressure monitoring interval to ensure transport by diffusion only. Concentration time-series in the APW within the borehole intervals were obtained, as well as 2D concentration distributions in the rock at the end of the experiment after overcoring and subsampling which resulted in ∼250 samples and ∼1300 analyses. As expected, HTO diffused the furthest into the rock, followed by the anions (Br, I, SeO4) and by the cationic sorbing tracers (Na-22, Ba-133, Cs, Cs-137, Co-60, Eu-152). The diffusion of SeO4 was slower than that of Br or I, approximately proportional to the ratio of their diffusion coefficients in water. Ba-133 diffused only into ∼0.1 m during the ∼4 a. Stable Cs, added at a higher concentration than Cs-137, diffused further into the rock than Cs-137, consistent with a non-linear sorption behavior. The rock properties (e.g., water contents) were rather homogeneous at the

  8. Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector–transduced CD34+ cells

    PubMed Central

    Kim, Yoo-Jin; Kim, Yoon-Sang; Larochelle, Andre; Renaud, Gabriel; Wolfsberg, Tyra G.; Adler, Rima; Donahue, Robert E.; Hematti, Peiman; Hong, Bum-Kee; Roayaei, Jean; Akagi, Keiko; Riberdy, Janice M.; Nienhuis, Arthur W.; Persons, Derek A.

    2009-01-01

    We previously reported that lentiviral vectors derived from the simian immunodeficiency virus (SIV) were efficient at transducing rhesus hematopoietic repopulating cells. To evaluate the persistence of vector-containing and -expressing cells long term, and the safety implications of SIV lentiviral vector–mediated gene transfer, we followed 3 rhesus macaques for more than 4 years after transplantation with transduced CD34+ cells. All 3 animals demonstrated significant vector marking and expression of the GFP transgene in T cells, B cells, and granulocytes, with mean GFP+ levels of 6.7% (range, 3.3%-13.0%), 7.4% (4.2%-13.4%), and 5.6% (3.1%-10.5%), respectively. There was no vector silencing in hematopoietic cells over time. Vector insertion site analysis of granulocytes demonstrated sustained highly polyclonal reconstitution, with no evidence for progression to oligoclonality. A significant number of clones were found to contribute at both 1-year and 3- or 4-year time points. No vector integrations were detected in the MDS1/EVI1 region, in contrast to our previous findings with a γ-retroviral vector. These data show that lentiviral vectors can mediate stable and efficient long-term expression in the progeny of transduced hematopoietic stem cells, with an integration profile that may be safer than that of standard Moloney murine leukemia virus (MLV)–derived retroviral vectors. PMID:19339698

  9. Attention Reorients Periodically.

    PubMed

    Dugué, Laura; Roberts, Mariel; Carrasco, Marisa

    2016-06-20

    Reorienting of voluntary attention enables the processing of stimuli at previously unattended locations. Although studies have identified a ventral fronto-parietal network underlying attention [1, 2], little is known about whether and how early visual areas are involved in involuntary [3, 4] and even less in voluntary [5] reorienting, and their temporal dynamics are unknown. We used transcranial magnetic stimulation (TMS) over the occipital cortex to interfere with attentional reorienting and study its role and temporal dynamics in this process. Human observers performed an orientation discrimination task, with either valid or invalid attention cueing, across a range of stimulus contrasts. Valid cueing induced a behavioral response gain increase, higher asymptotic performance for attended than unattended locations. During subsequent TMS sessions, observers performed the same task, with high stimulus contrast. Based on phosphene mapping, TMS double pulses were applied at one of various delays to a consistent brain location in retinotopic areas (V1/V2), corresponding to the evoked signal of the target or distractor, in a valid or invalid trial. Thus, the stimulation was identical for the four experimental conditions (valid/invalid cue condition × target/distractor-stimulated). TMS modulation of the target and distractor were both periodic (5 Hz, theta) and out of phase with respect to each other in invalid trials only, when attention had to be disengaged from the distractor and reoriented to the target location. Reorientation of voluntary attention periodically involves V1/V2 at the theta frequency. These results suggest that TMS probes theta phase-reset by attentional reorienting and help link periodic sampling in time and attention reorienting in space. PMID:27265395

  10. Growth hormone treatment of adolescents with growth hormone deficiency (GHD) during the transition period: results of a survey among adult and paediatric endocrinologists from Italy. Endorsed by SIEDP/ISPED, AME, SIE, SIMA.

    PubMed

    Aimaretti, G; Attanasio, R; Cannavò, S; Nicoletti, M C; Castello, R; Di Somma, C; Garofalo, P; Iughetti, L; Loche, S; Maghnie, M; Mazzanti, L; Saggese, G; Salerno, M; Tonini, G; Toscano, V; Zucchini, S; Cappa, M

    2015-03-01

    Treatment of adolescents with growth hormone deficiency (GHD) during the transition period is a controversial issue. This paper is a contribution from the Italian community of paediatric and adult endocrinologists surveyed in a Delphi panel. The Delphi method is a structured communication technique, originally developed as a systematic, interactive forecasting method that relies on a panel of experts. The experts answer questionnaires in two or more rounds. There was substantial agreement on the definition of the problems associated with the diagnosis and treatment of adolescents with GHD in the transition period, as well as on the identification of the controversial issues which need further studies. There is general consensus on the need of re-testing all isolated idiopathic GHD after at least 30-day withdrawn from treatment, while in patients with multiple pituitary deficiency and low IGF-I levels there is generally no need to re-test. In patients with permanent or confirmed GHD, a starting low rhGH dose (0.01-0.03 mg per day) to be adjusted according to IGF-I concentrations is also widely accepted. For those continuing treatment, the optimal therapeutic schedule to obtain full somatic maturation, normalization of body composition and bone density, cardiovascular function and Quality of Life, need to be evaluated. PMID:25362629

  11. Evidence of past climate change in the Little Ice Age and of the Pacific Decadal Oscillation periodicity in Africa: comparison between two neighbor stalagmites from Namibia and Botswana (preliminary results)

    NASA Astrophysics Data System (ADS)

    Voarintsoa, N. G.; Railsback, L. B.; Liang, F.; Brook, G. A.; Cheng, H.; Edwards, R.

    2013-12-01

    Stalagmites are potential sources of paleoenvironmental records because their characteristics respond to climate change. In this preliminary study we compare isotopic values resolvable at annual to bi-annual scale from two stalagmites from caves in Proterozoic dolomitic marbles, as a proxy for the past climate variability in Southern Africa. Stalagmite DP1 is from Dante Cave in the Otjozondjupa region of Namibia, and Stalagmite BC97-14 is from Bone Cave, in the Koanaka Hills of Northwest Botswana, ~125km west of the Okavango Delta. Dante and Bone Cave receive respectively ~532 and ~475mm annual rainfall with an annual average temperature of 21.0°C and 22.6°C. Both caves are in semi-arid areas with highly seasonal rainfall. Vegetation is distinctive for each location: deciduous woodland savanna with a relatively high diversity of scattered tall trees on the hill in which Dante is located and a sparser tree cover on the hillsite of Bone Cave area. The data from the two stalagmites are very different, reflecting the distinctive hydrological and vegetation settings of the caves where they formed. δ18O in BC97-14 is highly variable, ranging from -11.6 to -5.8 ‰, while δ13C is nearly constant (-10.5 to -8.5 ‰). In contrast, δ13C and δ18O are covariant in DP1, with much higher δ13C values (-10.8 to -5.1‰) and much lower δ18O (-11.7 to -6.5 ‰) compared to that of Bone Cave. The distance from the water vapor source (Indian Ocean) might explain the generally lower δ18O values from the Namibian stalagmite compared to that of Botswana; while the difference in vegetation cover reflects the difference between δ13C for the two areas. Regardless of this isotopic difference, the stalagmite data for Bone Cave show a marked 15- to 22-year periodicity that is much more subdued in the Namibia speleothem. This cycle matches with the 17- or 18-year periodicity in the Botswana historical rainfall record. The periodicity is very well pronounced between AD 1825 to 1925

  12. Prevalence of Chlamydia trachomatis, Ureaplasma spp., Mycoplasma genitalium and Mycoplasma hominis among outpatients in central Greece: absence of tetracycline resistance gene tet(M) over a 4-year period study

    PubMed Central

    Ikonomidis, A.; Venetis, C.; Georgantzis, D.; Giaslakiotis, V.; Kolovos, V.; Efstathiou, K.; Moschou, M.; Κoutsiaris, Ε.; Panopoulou, M.

    2015-01-01

    A total of 301 men and women attending local urologists and gynaecologists in the state of Thessaly, central Greece, were tested for Chlamydia trachomatis, Ureaplasma spp., Mycoplasma genitalium and Mycoplasma hominis DNA. Investigation of the tet(M) gene, which confers tetracycline resistance in these genera, was also performed. Low incidence of C. trachomatis and Mycoplasma spp. as well as high prevalence of Ureaplasma spp., especially among women, were found. The tet(M) gene was absent in all cases, notably in a region where doxycycline administration remains the first therapeutic option unless special medical conditions direct otherwise. PMID:26862428

  13. Period meter for reactors

    DOEpatents

    Rusch, Gordon K.

    1976-01-06

    An improved log N amplifier type nuclear reactor period meter with reduced probability for noise-induced scrams is provided. With the reactor at low power levels a sampling circuit is provided to determine the reactor period by measuring the finite change in the amplitude of the log N amplifier output signal for a predetermined time period, while at high power levels, differentiation of the log N amplifier output signal provides an additional measure of the reactor period.

  14. The Periodic Pyramid

    ERIC Educational Resources Information Center

    Hennigan, Jennifer N.; Grubbs, W. Tandy

    2013-01-01

    The chemical elements present in the modern periodic table are arranged in terms of atomic numbers and chemical periodicity. Periodicity arises from quantum mechanical limitations on how many electrons can occupy various shells and subshells of an atom. The shell model of the atom predicts that a maximum of 2, 8, 18, and 32 electrons can occupy…

  15. Testing for periodicity of extinction

    NASA Technical Reports Server (NTRS)

    Raup, David M.; Sepkoski, J. J., Jr.

    1988-01-01

    The statistical techniques used by Raup and Sepkoski (1984 and 1986) to identify a 26-Myr periodicity in the biological extinction record for the past 250 Myr are reexamined, responding in detail to the criticisms of Stigler and Wagner (1987). It is argued that evaluation of a much larger set of extinction data using a time scale with 51 sampling intervals supports the finding of periodicity. In a reply by Sigler and Wagner, the preference for a 26-Myr period is attributed to a numerical quirk in the Harland et al. (1982) time scale, in which the subinterval boundaries are not linear interpolations between the stage boundaries but have 25-Myr periodicity. It is stressed that the results of the stringent statistical tests imposed do not disprove periodicity but rather indicate that the evidence and analyses presented so far are inadequate.

  16. Schuler Period in LEO Satellites

    NASA Technical Reports Server (NTRS)

    Carpenter, Russell J.; Bar-Itzhack, Itzhack Y.

    2004-01-01

    This paper generalizes and extends the concept of the Schuler oscillation that occurs in the theory of inertial navigation systems, allowing one to see how the Schuler phenomenon affects inertial navigation systems operating in space. We show why a low earth orbit satellite's orbital period is identical to the period of the Schuler pendulum, which is the period of the errors for terrestrial inertial navigation systems. We also show that the generalized form of the Schuler oscillation takes the same form as the Hill-Clohessy-Wiltshire equations for satellite relative motion and that the period of the out-of-plane motion in neighboring satellite relative trajectories is the same as the Schuler period. Finally, we describe how INS gyro drift manifests itself in different coordinate systems for the orbital case. These results may assist orbital flight dynamics and attitude control systems engineers in the design and analysis of INS-equipped spacecraft

  17. Incorporating Spectra Into Periodic Timing

    NASA Astrophysics Data System (ADS)

    Connors, Alanna; Hong, J.; Protopapas, P.; Kashyap, V.

    2011-09-01

    The Chandra surveys have resulted in a wealth of data on low-luminosity X-ray sources (Lx 1030-34 erg/s) of Galactic scales beyond the local solar neighborhood. Many of these are compact binaries, in particular, cataclysmic variables, often identified by their periodic X-ray variability and spectra. Hong et al. (2009, 2011) have used energy quantiles (Hong, Schlegel & Grindlay, 2004) as a fast, robust indicator of spectral hardness and absorption of the X-ray sources. Energy quantiles also enable a simple but effective illustration of spectral changes with phase in these periodic systems: e.g. absorption by the accreting material is understood to drive the periodic light-curves. An interesting question is how to best make use of the information encapsulated in the periodic change in energy spectrum, along with the periodic change in intensity, especially for cases of ambiguous period determination? And, how to do it computationally efficiently? A first approach is to do the period search in intensity, as is standard; and then use a criterion of spectral variation to verify possible periods. Huijse, Zegers & Protopapas (2011) recently demonstrated a powerful period estimation technique using information potential and correntropy embedded in the light curve. Similar quantities based on energies (or energy quantiles) of X-ray photons can serve as criteria of spectral variation. A different approach treats the spectrum variations and intensity variations completely independently, searching through period-space in each, and then combining the results. A more general method would include both at the same time, looking for statistically significant variations above what is expected for a constant (in intensity and spectrum).

  18. Looking But Not Seeing: Atypical Visual Scanning and Recognition of Faces in 2 and 4-Year-Old Children with Autism Spectrum Disorder

    PubMed Central

    Shic, Frederick

    2016-01-01

    This study used eye-tracking to examine visual scanning and recognition of faces by 2- and 4-year-old children with autism spectrum disorder (ASD) (N = 44) and typically developing (TD) controls (N = 30). TD toddlers at both age levels scanned and recognized faces similarly. Toddlers with ASD looked increasingly away from faces with age, atypically attended to key features of faces, and were impaired in face recognition. Deficits in recognition were associated with imbalanced attention between key facial features. This study illustrates that face processing in ASD may be affected early and become further compromised with age. We propose that deficits in face processing likely impact the effectiveness of toddlers with ASD as social partners and thus should be targeted for intervention. PMID:19590943

  19. Child anxiety treatment: outcomes in adolescence and impact on substance use and depression at 7.4-year follow-up.

    PubMed

    Kendall, Philip C; Safford, Scott; Flannery-Schroeder, Ellen; Webb, Alicia

    2004-04-01

    Research suggests that the sequelae of childhood anxiety disorders, if left untreated, can include chronic anxiety, depression, and substance abuse. The current study evaluated the maintenance of outcomes of children who received a 16-week cognitive-behavioral treatment for primary anxiety disorders (generalized, separation, and social anxiety disorders) an average of 7.4 years earlier. The 86 participants (ages 15 to 22 years; 91% of the original sample) and their parents completed diagnostic interviews and self- and parent-report measures. According to the diagnostic interviews, a meaningful percentage of participants maintained significant improvements in anxiety at long-term follow-up. With regard to sequelae, positive responders to anxiety treatment, as compared with less positive responders, had a reduced amount of substance use involvement and related problems at long-term follow-up. The findings are discussed with regard to child anxiety and some of its sequelae. PMID:15065961

  20. Looking but not seeing: atypical visual scanning and recognition of faces in 2 and 4-year-old children with autism spectrum disorder.

    PubMed

    Chawarska, Katarzyna; Shic, Frederick

    2009-12-01

    This study used eye-tracking to examine visual scanning and recognition of faces by 2- and 4-year-old children with autism spectrum disorder (ASD) (N = 44) and typically developing (TD) controls (N = 30). TD toddlers at both age levels scanned and recognized faces similarly. Toddlers with ASD looked increasingly away from faces with age, atypically attended to key features of faces, and were impaired in face recognition. Deficits in recognition were associated with imbalanced attention between key facial features. This study illustrates that face processing in ASD may be affected early and become further compromised with age. We propose that deficits in face processing likely impact the effectiveness of toddlers with ASD as social partners and thus should be targeted for intervention. PMID:19590943

  1. The impact of different flooding periods on the dynamics of pore water concentrations of As, Cr, Mo and V in a contaminated floodplain soil - results of a lysimeter study

    NASA Astrophysics Data System (ADS)

    Rupp, Holger; Meissner, Ralph; Shaheen, Sabry; Rinklebe, Jörg

    2014-05-01

    Trace elements and arsenic (As) were transported with water during inundation in floodplain ecosystems, where they settled down and accumulated predominantly in depressions and low-lying terraces. Highly variable hydrological conditions in floodplains can affect the dynamics of pollutants. The impact of different flooding/drying periods on the temporal dynamics of pore water concentrations of As, Cr, Mo and V as a function of soil EH/pH changes and dynamics of DOC, Fe, Mn and SO42- was studied in a contaminated floodplain soil collected at the Elbe River (Germany). A specific groundwater lysimeter technique with two separate small lysimeter vessels served as replicates was used for this study. The groundwater level inside the lysimeters was controlled to simulate long term and short term flooding/drying. The long term (LT) flooding scenario consists of 94 days of flooding followed by similar drying term. The short term (ST) flooding/drying scenario comprises 21 days and was six times repeated. The entire experimental period (LT_ST) was about 450 days. Flooding of the soil caused a significant decrease of EH and pH. Concentrations of soluble As, Cr, Fe, Mn, Mo and DOC were higher under reducing conditions than under oxidizing conditions in LT. However, As and Cr tended to be mobilized under oxidizing conditions during ST, which might be due to slow kinetics of the redox reaction of As and Cr. Dynamics of Mo were more affected by changes of EH/pH as compared to As, Cr and V and governed mainly by Fe-Mn chemistry. Concentrations of V in ST were higher than in LT and were controlled particularly by pH and chemistry of Fe. The interactions between the elements and carriers studied were stronger during long flood-dry-cycles than during short cycles, which confirmed our hypothesis. We conclude that the dynamics of As, Cr, Mo and V are determined by the length of time soils are exposed to flooding, because drivers of element mobility need a certain time to provoke

  2. Long-term effects following 4 years of randomized treatment with atorvastatin in patients with type 2 diabetes mellitus on hemodialysis.

    PubMed

    Krane, Vera; Schmidt, Kay-Renke; Gutjahr-Lengsfeld, Lena J; Mann, Johannes F E; März, Winfried; Swoboda, Florian; Wanner, Christoph

    2016-06-01

    The 4D (Die Deutsche Diabetes Dialyse) Study was a randomized, double-blind trial comparing 4 years of treatment with atorvastatin to placebo in 1255 hemodialysis patients with type 2 diabetes. The primary end point of cardiovascular events (cardiac death, myocardial infarction, and stroke) was non-significantly reduced by 8%. However, long-term effects remained uncertain. Therefore, surviving patients were invited to a follow-up survey done by questionnaire. Post-trial statin therapy was at nephrologist discretion, and outcomes were centrally adjudicated and analyzed by intention to treat and time to first event in the original treatment groups. Median overall follow-up was 11.5 years. Post-trial statin use and low-density lipoprotein cholesterol levels did not differ between groups. Statin treatment non-significantly affected the former primary outcome (relative risk, 0.91; 95% confidence interval, 0.78-1.07). The risk of all cardiac events combined and the risk of cardiac death were significantly lower in the original statin group compared to placebo (0.83, 0.70-0.97, and 0.80, 0.66-0.97). No significant effect was detected on cerebrovascular events, fatal stroke, fatal cancer, non-vascular, or all-cause death. No rhabdomyolysis was reported. Thus, after 4 years of atorvastatin treatment in diabetic hemodialysis patients, similar effects on outcomes were found after 11.5 years of follow-up as were found at the end of the original study. There was no evidence of emerging hazards in the long term, confirming current clinical practice guidelines. PMID:26924051

  3. Towards extracting the best possible results from NOν A

    NASA Astrophysics Data System (ADS)

    Soumya, C.; Mohanta, R.

    2016-06-01

    The NuMI Off-Axis ν e Appearance (NOν A) is the currently running leading long-baseline neutrino oscillation experiment, whose main physics goal is to explore the current issues in the neutrino sector, such as determination of the neutrino mass ordering, resolution of the octant of the atmospheric mixing angle, and to constrain the Dirac-type CP violating phase δ _CP. In this paper, we would like to investigate whether it is possible to extract the best possible results from NOν A with a shorter time span than its scheduled run period by analyzing its capability to discriminate the degeneracy among various neutrino oscillation parameters within 4 years of run time, with 2 years in each neutrino and antineutrino modes. Further, we study the same by adding the data from the T2K experiment for a total of 5 years run with 3.5 years in neutrino mode and 1.5 years in antineutrino mode. We find that NOν A (2+2) has a better oscillation parameter degeneracy discrimination capability compared to its scheduled run period for 4 years, i.e., NOν A (3+1).

  4. The first results of the development and implementation of the upper extremity exoskeleton "EXAR"

    NASA Astrophysics Data System (ADS)

    Vorobiev, A. A.; Krivonozhkina, P. S.; Zasypkina, O. A.; Andrewshenko, F. A.

    2015-11-01

    This research considers the first results of the development and implementation of the upper extremity exoskeleton "EXAR". Made anatomical parameterization developed the device the testing of the apparatus have been conducted in accordance with the bioethics regulations with the girl I. Sh. at the age of 4 years suffering the artrogryposis. The parameters of the exoskeleton "EXAR" selected according to our methods allowed us to conduct its use in the period of 4 months. There have been no defects at all. By the analysis of the first results of the passive upper limb skeleton EXAR development we should consider them as positive and worthy of the widespread adoption in the remedial practice.

  5. Single-Bundle Anterior Cruciate Ligament Reconstruction with Semitendinosus Tendon Using the PINN-ACL CrossPin System: Minimum 4-Year Follow-up

    PubMed Central

    Baek, Seung-Gil; Lee, Byoung-Joo; Lee, Chang-Hwa

    2015-01-01

    Purpose This study evaluated mid-term results of anterior cruciate ligament (ACL) reconstruction using the PINN-ACL CrossPin system that allowed for short graft fixation. Materials and Methods Forty-three patients underwent single-bundle ACL reconstruction with a 4-strand semitendinosus tendon graft using the PINN-ACL CrossPin system. Femoral fixation was done using the PINN-ACL CrossPin system, and the tibial side was fixed with post-tie and a bioabsorbable interference screw. The mean follow-up period was 50 months. Evaluation was done using the Lachman test, pivot-shift test, International Knee Documentation Committee (IKDC) score and grade. Anterior displacement was assessed. Results There was improvement in the Lachman test and pivot-shift test at final follow-up, form grade II (n=40) or III (n=3) to grade I (n=3) or 0 (n=40) and from grade I (n=20) or II (n=10) to grade I (n=8) or 0 (n=22), respectively. The mean IKDC score was 88.7, and grade A and B were 93.0% at final follow-up. Side-to-side difference was improved from 6.7 mm to 2.1 mm at final follow-up. Complications occurred in 3 patients, a re-ruptured due to trauma at 2 years after surgery and a deep infection and a superficial infection. Conclusions The mid-term follow-up results of ACL reconstruction with the PINN-ACL CrossPin system were satisfactory. The PINN-ACL CrossPin can be considered as a useful instrument for short graft fixation. PMID:25750893

  6. The Changes of Pulmonary Function in COPD During Four-Year Period

    PubMed Central

    Cukic, Vesna; Lovre, Vladimir; Ustamujic, Aida

    2013-01-01

    Conflict of interest: none declared. Introduction COPD (chronic obstructive pulmonary disease) is characterized by airflow limitation that is not fully reversible. OBJECTIVE: to show the changes of pulmonary function in COPD during the 4 -year evolution of illness. Material and Methods The research was done on patients suffering from COPD treated at the Clinic “Podhrastovi” during 2006 and 2007. The tested parameters were examined from the date of receiving patient with COPD to hospital treatment in 2006 and 2007 and then followed prospectively until 2010 or 2011 (the follow-up period was 4 years). There were total 199 treated patients who were chosen at random and regularly attended the control examinations. The study was conducted on adult patients of both sexes, different age group. In each patient the duration of illness was recorded so is sex, age, data of smoking habits, information about the regularity of taking bronchodilator therapy during remissions of disease, about the treatment of disease exacerbations, results of pulmonary functional tests as follows: FVC (forced vital capacity), FEV1 (forced expiratory volume in one second) and bronchodilator reversibility testing. All these parameters were measured at the beginning and at the end of each hospital treatment on the apparatuses of Clinic “Podhrastovi”. We took in elaboration those data obtained in the beginning of the first hospitalization and at the end of the last hospitalization or at the last control in outpatient department when patient was in stable state. Patients were divided into three groups according to the number of exacerbations per year. Results airflow limitation in COPD is progressive; both FVC and FEV1 shows the statistically significant decrease during follow-up period of 4 years (p values / for both parameters/ =0.05) . But in patients regularly treated in phases of remission and exacerbations of illness the course of illness is slower. The fall of FVC and FEV1 is

  7. Automated Periodical Reference Service.

    ERIC Educational Resources Information Center

    Ellefsen, David

    1985-01-01

    Describes public library reference service which allows patrons to type out search instructions on a computer terminal, review and select references, and receive, by high-speed printer, facsimile copy of selected periodical articles. Development of periodicals center at main county library and use of self-coaching SEARCH HELPER system are…

  8. The Living Periodic Table

    ERIC Educational Resources Information Center

    Nahlik, Mary Schrodt

    2005-01-01

    To help make the abstract world of chemistry more concrete eighth-grade students, the author has them create a living periodic table that can be displayed in the classroom or hallway. This display includes information about the elements arranged in the traditional periodic table format, but also includes visual real-world representations of the…

  9. Bragg interactions in periodic media

    NASA Technical Reports Server (NTRS)

    Jaggard, D. L.

    1976-01-01

    The interaction of electromagnetic waves of wavelength lambda with periodic structures of spatial period lambda are studied. The emphasis of the work is on Bragg interactions where lambda approximately equal to 2 lambda/N and the Bragg order N takes on the values 1, 2,.... An extended coupled waves (ECW) theory is developed for the case N greater or equal to 2 and the results of the theory are found to compare favorably with the exact results of Floquet theory. Numerous numerical results are displayed as Brillouin diagrams for the first few Bragg orders. Moreover, explicit expressions for coupling coefficients, bandgap shifts and bandgap widths are derived for singly periodic media. Particular note is taken of phase speeding effects.

  10. On composites with periodic structure

    NASA Technical Reports Server (NTRS)

    Nemat-Nasser, S.; Iwakuma, T.; Hejazi, M.

    1982-01-01

    The overall moduli of a composite with an isotropic elastic matrix containing periodically distributed (anisotropic) inclusions or voids, can be expressed in terms of several infinite series which only depend on the geometry of the inclusions or voids, and hence can be computed once and for all for given geometries. For solids with periodic structures these infinite series play exactly the same role as does Eshelby's tensor for a single inclusion or void in an unbounded elastic medium. For spherical and circular-cylindrical geometries, the required infinite series are calculated and the results are tabulated. These are then used to estimate the overall elastic moduli when either the overall strains or the overall stresses are prescribed, obtaining the same results. These results are compared with other estimates and with experimental data. It is found that the model of composites with periodic structure yields estimates in excellent agreement with the experimental observations.

  11. Safety and immunogenicity of Vi conjugate vaccines for typhoid fever in adults, teenagers, and 2- to 4-year-old children in Vietnam.

    PubMed

    Kossaczka, Z; Lin, F Y; Ho, V A; Thuy, N T; Van Bay, P; Thanh, T C; Khiem, H B; Trach, D D; Karpas, A; Hunt, S; Bryla, D A; Schneerson, R; Robbins, J B; Szu, S C

    1999-11-01

    The capsular polysaccharide of Salmonella typhi, Vi, is an essential virulence factor and a protective vaccine for people older than 5 years. The safety and immunogenicity of two investigational Vi conjugate vaccines were evaluated in adults, 5- to 14-year-old children, and 2- to 4-year-old children in Vietnam. The conjugates were prepared with Pseudomonas aeruginosa recombinant exoprotein A (rEPA) as the carrier, using either N-succinimidyl-3-(2-pyridyldithio)-propionate (SPDP; Vi-rEPA(1)) or adipic acid dihydrazide (ADH; Vi-rEPA(2)) as linkers. None of the recipients experienced a temperature of >38.5 degrees C or significant local reactions. One injection of Vi-rEPA(2) into adults elicited a geometric mean (GM) increase in anti-Vi immunoglobulin G (IgG) from 9.62 enzyme-linked immunosorbent assay units/ml (EU) to 465 EU at 6 weeks; this level fell to 119 EU after 26 weeks. In the 5- to 14-year-old children, anti-Vi IgG levels at 6 weeks elicited by Vi-rEPA(2), Vi-rEPA(1), and Vi were 169, 22.8, and 18.9 EU, respectively (P = 0.0001 for Vi-rEPA(1) and Vi with respect to Vi-rEPA(2)). At 26 weeks, the anti-Vi IgG levels for recipients of Vi-rEPA(2), Vi-rEPA(1), and Vi were 30.0, 10.8, and 13.4 EU, respectively (P < 0.001 for Vi-rEPA(1) and Vi with respect to Vi-rEPA(2)); all were higher than the preinjection levels (P = 0. 0001). Vi-rEPA(2) also elicited the highest anti-Vi IgM and IgA levels of the three vaccines. In the 2- to 4-year-old children at 6 weeks following the first injection, Vi-rEPA(2) elicited an anti-Vi IgG level of 69.9 EU compared to 28.9 EU for Vi-rEPA(1) (P = 0.0001). Reinjection increased Vi antibody levels from 69.9 to 95.4 EU for Vi-rEPA(2) and from 28.9 to 83.0 EU for Vi-rEPA(1). At 26 weeks, anti-Vi IgG levels remained higher than those at preinjection (30.6 versus 0.18 for Vi-rEPA(2) and 12.8 versus 0.33 for Vi-rEPA(1); P = 0.0001 for both). Vi vaccine is recommended for individuals of 5 years of age or older. In the present study, the GM

  12. Wavelet periodicity detection algorithms

    NASA Astrophysics Data System (ADS)

    Benedetto, John J.; Pfander, Goetz E.

    1998-10-01

    This paper deals with the analysis of time series with respect to certain known periodicities. In particular, we shall present a fast method aimed at detecting periodic behavior inherent in noise data. The method is composed of three steps: (1) Non-noisy data are analyzed through spectral and wavelet methods to extract specific periodic patterns of interest. (2) Using these patterns, we construct an optimal piecewise constant wavelet designed to detect the underlying periodicities. (3) We introduce a fast discretized version of the continuous wavelet transform, as well as waveletgram averaging techniques, to detect occurrence and period of these periodicities. The algorithm is formulated to provide real time implementation. Our procedure is generally applicable to detect locally periodic components in signals s which can be modeled as s(t) equals A(t)F(h(t)) + N(t) for t in I, where F is a periodic signal, A is a non-negative slowly varying function, and h is strictly increasing with h' slowly varying, N denotes background activity. For example, the method can be applied in the context of epileptic seizure detection. In this case, we try to detect seizure periodics in EEG and ECoG data. In the case of ECoG data, N is essentially 1/f noise. In the case of EEG data and for t in I,N includes noise due to cranial geometry and densities. In both cases N also includes standard low frequency rhythms. Periodicity detection has other applications including ocean wave prediction, cockpit motion sickness prediction, and minefield detection.

  13. Intravenous injection of AAVrh10-GALC after the neonatal period in twitcher mice results in significant expression in the central and peripheral nervous systems and improvement of clinical features.

    PubMed

    Rafi, Mohammad A; Rao, Han Zhi; Luzi, Paola; Luddi, Alice; Curtis, Mark T; Wenger, David A

    2015-03-01

    Globoid cell leukodystrophy (GLD) or Krabbe disease is an autosomal recessive disorder resulting from the defective lysosomal enzyme galactocerebrosidase (GALC). The lack of GALC enzyme leads to severe neurological symptoms. While most human patients are infants who do not survive beyond 2 years of age, older patients are also diagnosed. In addition to human patients, several naturally occurring animal models, including dog, mouse, and monkey, have also been identified. The mouse model of Krabbe disease, twitcher (twi) mouse has been used for many treatment trials including gene therapy. Using the combination of intracerebroventricular, intracerebellar, and intravenous (iv) injection of the adeno-associated virus serotype rh10 (AAVrh10) expressing mouse GALC in neonate twi mice we previously have demonstrated a significantly extended normal life and exhibition of normal behavior in treated mice. In spite of the prolonged healthy life of these treated mice and improved myelination, it is unlikely that using multiple injection sites for viral administration will be approved for treatment of human patients. In this study, we have explored the outcome of the single iv injection of viral vector at post-natal day 10 (PND10). This has resulted in increased GALC activity in the central nervous system (CNS) and high GALC activity in the peripheral nervous system (PNS). As we have shown previously, an iv injection of AAVrh10 at PND2 results in a small extension of life beyond the typical lifespan of the untreated twi mice (~40 days). In this study, we report that mice receiving a single iv injection at PND10 had no tremor and continued to gain weight until a few weeks before they died. On average, they lived 20-25 days longer than untreated mice. We anticipate that this strategy in combination with other therapeutic options may be beneficial and applicable to treatment of human patients. PMID:25533112

  14. The dependence of honey-bee behaviour on weather — Shown by the results of weighing bee-hives in the period of 1969 to 1978 in the region of the Beekeepers Association of Hannover

    NASA Astrophysics Data System (ADS)

    Gerlach, Jutta

    1985-03-01

    This paper presents the results of an investigation of honey bee behaviour and their dependence on weather conditions. The main interest of the data evaluation was the rentability of beekeeping, especially the amount of honey produced, meteorological parameters were used to analyse the measurements. So-called “hive scale” measurements, a method used to judge the annual development of honey bees, were carried out in the region of the “Landesverband Hannoverscher Imker e. V.” by 30 to 35 observers from 1969 to 1978 under the direction of Wagener. Number of flight and forage days were collected in addition to climatic data and evaluated.

  15. Periodized Daubechies wavelets

    SciTech Connect

    Restrepo, J.M.; Leaf, G.K.; Schlossnagle, G.

    1996-03-01

    The properties of periodized Daubechies wavelets on [0,1] are detailed and counterparts which form a basis for L{sup 2}(R). Numerical examples illustrate the analytical estimates for convergence and demonstrated by comparison with Fourier spectral methods the superiority of wavelet projection methods for approximations. The analytical solution to inner products of periodized wavelets and their derivatives, which are known as connection coefficients, is presented, and their use ius illustrated in the approximation of two commonly used differential operators. The periodization of the connection coefficients in Galerkin schemes is presented in detail.

  16. Compensation for a lip-tube perturbation in 4-year-olds: Articulatory, acoustic, and perceptual data analyzed in comparison with adults.

    PubMed

    Ménard, Lucie; Perrier, Pascal; Aubin, Jérôme

    2016-05-01

    The nature of the speech goal in children was investigated in a study of compensation strategies for a lip-tube perturbation. Acoustic, articulatory, and perceptual analyses of the vowels /y/ and /u/ produced by ten 4-year-old French speakers and ten adult French speakers were conducted under two conditions: normal and with a large tube inserted between the lips. Ultrasound and acoustic recordings of isolated vowels were made in the normal condition before any perturbation, for each of the trials in the perturbed condition, and in the normal condition after the perturbed trials. Data revealed that adult participants moved their tongues in the perturbed condition more than children did. The perturbation was generally at least partly compensated for during the perturbed trials in adults, but children did not show a typical learning effect. In particular, unsystematic improvements were observed during the sequence of perturbed trials, and after-effects were not clear in the articulatory domain. This suggests that children may establish associative links between multisensory phonemic representations and articulatory maneuvers, but those links may mainly rely on trial-to-trial, error-based feedback correction mechanisms rather than on the internal model of the speech production apparatus, as they are in adults. PMID:27250147

  17. Imitation as a mechanism in cognitive development: a cross-cultural investigation of 4-year-old children’s rule learning

    PubMed Central

    Wang, Zhidan; Williamson, Rebecca A.; Meltzoff, Andrew N.

    2015-01-01

    Children learn about the social and physical world by observing other people’s acts. This experiment tests both Chinese and American children’s learning of a rule. For theoretical reasons we chose the rule of categorizing objects by the weight. Children, age 4 years, saw an adult heft four visually-identical objects and sort them into two bins based on an invisible property—the object’s weight. Children who saw this categorization behavior were more likely to sort those objects by weight than were children who saw control actions using the same objects and the same bins. Crucially, children also generalized to a novel set of objects with no further demonstration, suggesting rule learning. We also report that high-fidelity imitation of the adult’s “hefting” acts may give children crucial experience with the objects’ weights, which could then be used to infer the more abstract rule. The connection of perception, action, and cognition was found in children from both cultures, which leads to broad implications for how the imitation of adults’ acts functions as a lever in cognitive development. PMID:26029132

  18. Chronic Candida albicans Meningitis in a 4-Year-Old Girl with a Homozygous Mutation in the CARD9 Gene (Q295X).

    PubMed

    Herbst, Martin; Gazendam, Roel; Reimnitz, Denise; Sawalle-Belohradsky, Julie; Groll, Andreas; Schlegel, Paul-Gerhardt; Belohradsky, Bernd; Renner, Ellen; Klepper, Jörg; Grimbacher, Bodo; Kuijpers, Taco; Liese, Johannes

    2015-09-01

    A 4-year-old Turkish girl of consanguineous parents was hospitalized for the evaluation of headaches and recurrent febrile episodes of unknown origin. Her medical history was unremarkable except for a few episodes of uncomplicated oral thrush. Meningitis was diagnosed, and Candida albicans was the only pathogen identified by polymerase chain reaction and culture. Despite systemic antifungal multidrug therapy, a prolonged course of 16 months of therapy was necessary to clear C. albicans from the cerebrospinal fluid. Molecular genetic analysis revealed a homozygous caspase recruitment domain 9 (CARD9) mutation (Q295X), which was reported to predispose to chronic mucocutaneous candidiasis. Immunologic workup excluded predisposing B-cell and T-cell defects. In addition, T cells producing interleukin-17 were repeatedly measured within the normal range. Analyses of neutrophils demonstrated normal nicotinamide adenine dinucleotide phosphate oxidase activity in response to various stimuli including Staphylococcus aureus and C. albicans. Additional neutrophilic functional testing, however, showed a decreased cytotoxicity to nonopsonized C. albicans, indicating an impaired killing mechanism against Candida spp. independent from the production of reactive oxygen species by the nicotinamide adenine dinucleotide phosphate oxidase system. Because this defect was only demonstrated in the absence of opsonins, it might especially predispose to chronic C. albicans infections in the central nervous system where opsonin concentrations are usually low. We, therefore, suggest that due to an additional neutrophil dependent defect CARD9 deficiency predisposes not only to chronic mucocutaneous candidiasis, but also to invasive chronic Candida infections, especially of the central nervous system. PMID:25933095

  19. Lack of physiological responses to hydrocarbon accumulation by Mytilus trossulus after 3-4 years chronic exposure to spilled Exxon Valdez crude oil in Prince William Sound.

    PubMed

    Thomas, R E; Brodersen, C; Carls, M G; Babcock, M; Rice, S D

    1999-01-01

    Mussels, Mytilus trossulus, were sampled in 1992 and 1993 from beaches in Prince William Sound that had been oiled by the Exxon Valdez spill of March, 1989. At some of the oiled beaches, mussels were collected from beds overlying oiled sediments, and from bedrock adjacent to these beds. Mussels were also collected from beaches within the Sound that had not been impacted by the spill. Polynuclear aromatic hydrocarbon (PAH) concentrations in mussel tissue, physiological responses (byssal thread production, condition index, clearance rate, and glycogen content), were determined for each group of mussels. Total PAH concentrations in mussel tissue ranged from 0 to 6 micrograms g-1, and were significantly greater in mussels from oiled beds than those from reference beds. No significant differences were noted in byssal thread production, condition index, clearance rate, or glycogen content between oiled sample sites and reference sites. The lack of physiological response was surprising because mussels in this study were chronically exposed to PAH for 3-4 years, and none of the physiological responses measured appeared to be affected by that exposure. The lack of a physiological response suggests that chronically exposed mussels may develop a physiological tolerance to PAH, but we recognize that these measures may not have been sensitive enough to discriminate response from background noise. PMID:10190040

  20. Reading Faces: Differential Lateral Gaze Bias in Processing Canine and Human Facial Expressions in Dogs and 4-Year-Old Children

    PubMed Central

    Racca, Anaïs; Guo, Kun; Meints, Kerstin; Mills, Daniel S.

    2012-01-01

    Sensitivity to the emotions of others provides clear biological advantages. However, in the case of heterospecific relationships, such as that existing between dogs and humans, there are additional challenges since some elements of the expression of emotions are species-specific. Given that faces provide important visual cues for communicating emotional state in both humans and dogs, and that processing of emotions is subject to brain lateralisation, we investigated lateral gaze bias in adult dogs when presented with pictures of expressive human and dog faces. Our analysis revealed clear differences in laterality of eye movements in dogs towards conspecific faces according to the emotional valence of the expressions. Differences were also found towards human faces, but to a lesser extent. For comparative purpose, a similar experiment was also run with 4-year-old children and it was observed that they showed differential processing of facial expressions compared to dogs, suggesting a species-dependent engagement of the right or left hemisphere in processing emotions. PMID:22558335

  1. The suitability of negative pions for radiotherapy: 4 years preclinical research with the biomedical PiE3-beam at SIN.

    PubMed

    Fritz-Niggli, H

    1979-08-10

    The radiobiological experiences over 4 years research with the biomedical pion channel of the 590 MeV proton-accelerator of the Swiss Institute for Nuclear Research (SIN) have been summarized. Mainly sensitive biological systems have been chosen (limiting factor: dose-rate not more than 10 rad/min, exceptionally till 30 rad/min). The RBE values in the peak region vary between 0.7-3.3 and in the plateau region between 0.4-1. The gain factors for pion radiotherapy of cancer are, beside the excellent physical dose distribution, irradiation in the same treatment with two types of radiation: sparsely ionizing (low LET) radiation in plateau (healthy tissue) region and densely ionizing (high LET) radiation in peak (tumor) region. The biological effectiveness ratio in peak and plateau as the clinically most important relation vary between 1.4-4.2. This is valid also for clinically limiting factors such as reaction of skin, of small intestine, vascular damage, dominant lethals in hypoxic cells, tumor induction. For peak pions the RBE in hypoxic cells (tumor cells) can be much higher than in euoxic cells (healthy tissue). This preclinical work supports the hope in a highly effective cancer therapy with negative pions. PMID:116302

  2. [Loeys-Dietz syndrome (TGFβR2 mutation) in a 4-year-old child with thoracic aortic aneurysm].

    PubMed

    De Potter, M-J; Edouard, T; Amadieu, R; Plaisancié, J; Julia, S; Hadeed, K; Hascoët, S; Acar, P; Dulac, Y

    2016-05-01

    Loeys-Dietz syndrome is a rare form of connective tissue disorder, whose clinical features can resemble those of Marfan syndrome, but with a more unpolished appearance. Recently brought out, this pathology remains little known; however, its consequences may be dramatic. We report on the case of a 4-year-old girl followed for a congenital hip dislocation, in which a systematic exam found increased cutaneous elasticity and a bifid uvula, suggesting a connective tissue disorder. Symptoms were unpolished, as the child's height was normal, without any positive cardiac, rheumatological, or ophthalmological family history. Cardiovascular tests found a thoracic aortic aneurysm at the Valsalva sinus (26mm, Z-score=+4.24). A genetic investigation found a TGFβR2 gene mutation, leading to the diagnosis of Loeys-Dietz syndrome type 2. Skeletal damage associated with bifid uvula and/or hypertelorism and an aneurysm of the ascending aorta should guide the genetic investigation to the search for TGF-β vasculopathy such as Loeys-Dietz syndrome. PMID:27017362

  3. [A case of non-resectable pancreatic cancer surviving more than 4 years by intra-arterial infusion chemotherapy with angiotensin-II].

    PubMed

    Tsuji, Y; Ohigashi, H; Ishikawa, O; Yasuda, T; Nakano, H; Nakamori, S; Kameyama, M; Hiratsuka, M; Sasaki, Y; Kabuto, T; Furukawa, H; Imaoka, S; Iwanaga, T

    1996-09-01

    This is a report of a 62-year-old woman whose non-resectable pancreatic cancer had been treated effectively by a new method of intra-arterial regional chemotherapy for more than 4 years. A catheter was placed into the celiac artery during laparotomy, and an intra -arterial chemotherapy (methotrexate (50 mg) and Angiotensin-II (AT-II, 5 micrograms)) has been repeated every other week (108 times) in addition to the external beam therapy (50 Gy). Both pain relief and "partial response" in the size of tumor have been obtained, with no hepatic metastasis or adverse effect. She died of brain metastasis at 51 postoperative months. Autopsy revealed that the pancreatic tumor was mostly replaced by fibrous connective tissues. Scintigraphic study indicated that the intra-arterial infusion of AT-II increased the blood flow in the tumor but decreased it in the surrounding non-cancerous tissues. This seemed to explain the effective loco-regional control in the present case. PMID:8854821

  4. Long-Term Outcome of Cognitive Behavior Therapy for Body Dysmorphic Disorder: A Naturalistic Case Series of 1 to 4 Years After a Controlled Trial.

    PubMed

    Veale, David; Miles, Sarah; Anson, Martin

    2015-11-01

    There is some evidence for the efficacy of cognitive behavior therapy (CBT) for body dysmorphic disorder (BDD) after 1 to 6months but none in the long term. The aim of this study was to follow up the participants in a randomized controlled trial of CBT versus anxiety management to determine whether or not the treatment gains were maintained over time. Thirty of the original 39 participants who had CBT were followed up over 1 to 4years and assessed using a number of clinician and self-report measures, which included the primary outcome measure of the Yale-Brown Obsessive Compulsive Scale modified for BDD. Outcome scores generally maintained over time from end of treatment to long-term follow-up. There was a slight deterioration from n=20 (51.3%) to n=18 (46.2%) who met improvement criteria at long-term follow-up. Eleven (28.2%) were in full remission and 22 (56.4%) were in partial remission. The gains made were generally maintained at long-term follow-up. However, there were a significant number of participants who maintained chronic symptoms after treatment and may need a longer-term or more complex intervention and active medication management. PMID:26520220

  5. Hypokalemic periodic paralysis

    MedlinePlus

    ... that may be due to this condition include: Kidney stones (a side effect of acetazolamide) Irregular heartbeat during ... 2016:chap 99. Read More Breathing difficulty Carbohydrates Kidney stones Potassium test Thyrotoxic periodic paralysis Weakness Update Date ...

  6. Thyrotoxic periodic paralysis

    MedlinePlus

    ... high levels of thyroid hormone in their blood ( hyperthyroidism , thyrotoxicosis). Causes This is a rare condition that ... include a family history of periodic paralysis and hyperthyroidism. Symptoms Symptoms involve attacks of muscle weakness or ...

  7. Vaginal bleeding between periods

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/003156.htm Vaginal bleeding between periods To use the sharing features ... this page, please enable JavaScript. This article discusses vaginal bleeding that occurs between a woman's monthly menstrual ...

  8. Painful periods (dysmenorrhea) (image)

    MedlinePlus

    ... may be caused by abnormal conditions such as endometriosis or pelvic inflammatory disease. Unless one of these potentially serious conditions is present, the treatment for painful periods is pain relief. If a ...

  9. Your First Period

    MedlinePlus

    ... severe asthma). Always follow the directions on the bottle about how much to take. Exercise. Place a ... days. Glossary Amenorrhea: The absence of menstrual periods. Egg: The female reproductive cell produced in and released ...

  10. The Periodic Table CD.

    ERIC Educational Resources Information Center

    Banks, Alton J.; Holmes, Jon L.

    1995-01-01

    Describes the characteristics of the digitized version of The Periodic Table Videodisc. Provides details about the organization of information and access to the data via Macintosh and Windows computers. (DDR)

  11. Painful periods (dysmenorrhea) (image)

    MedlinePlus

    Primary dysmenorrhea is a normal cramping of the lower abdomen caused by hormone-induced uterine contractions before the period. Secondary dysmenorrhea may be caused by abnormal conditions such as ...

  12. On almost periodic solutions of logistic delay differential equations with almost periodic time dependence

    NASA Astrophysics Data System (ADS)

    Yuan, Rong

    2007-06-01

    In this paper, we study almost periodic logistic delay differential equations. The existence and module of almost periodic solutions are investigated. In particular, we extend some results of Seifert in [G. Seifert, Almost periodic solutions of certain differential equations with piecewise constant delays and almost periodic time dependence, J. Differential Equations 164 (2000) 451-458].

  13. 7 CFR 1437.5 - Coverage period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Coverage period. 1437.5 Section 1437.5 Agriculture... Provisions § 1437.5 Coverage period. (a) The coverage period is the time during which coverage is available against loss of production of the eligible crop as a result of natural disaster. (b) The coverage...

  14. Histologic Typing in Oropharyngeal Squamous Cell Carcinoma: A 4-Year Prospective Practice Study With p16 and High-Risk HPV mRNA Testing Correlation.

    PubMed

    Gondim, Dikson Dibe; Haynes, Wesley; Wang, Xiaowei; Chernock, Rebecca D; El-Mofty, Samir K; Lewis, James S

    2016-08-01

    Oropharyngeal squamous cell carcinomas (OPSCCs) associated with human papillomavirus (HPV) represent a distinct clinical and pathologic entity. The majority of HPV-related OPSCCs have a characteristic nonkeratinizing morphology. This study sought to determine the strength of the association between nonkeratinizing histology and HPV status compared with other squamous cell carcinoma variants in 4 years of routine clinical practice on a high-volume head and neck service. Primary and/or nodal metastatic tumors in all cases of OPSCC from 2010 to 2013 were typed by 1 of 3 head and neck pathologists as keratinizing, nonkeratinizing, nonkeratinizing with maturation, or another defined variant. All were assessed for p16 by immunohistochemistry with a 70% nuclear and cytoplasmic positivity cutoff as part of routine clinical practice. In addition, 70 consecutive cases from 1 year were "audited" for high-risk HPV mRNA by reverse transcription polymerase chain reaction and in situ hybridization. Of the 435 cases, the majority (90%) consisted of 1 of the 3 main types described and the rest (10%) of uncommon variants. Nonkeratinizing morphology had 99.1% and 100.0% positive predictive value for p16 and high-risk HPV mRNA positivity, respectively. Nonkeratinizing with maturation, keratinizing, and other specific squamous cell carcinoma variants were p16 positive in 91.8%, 22.8%, and 79.5%, respectively. All 47 nonkeratinizing OPSCCs tested for HPV mRNA were positive. In summary, strictly defined nonkeratinizing OPSCC (which constitutes ∼55% of all tumors) essentially implies positivity for both p16 and transcriptionally active high-risk HPV. PMID:27035614

  15. Fruit and vegetable intakes, sources and contribution to total diet in very young children (1-4 years): the Irish National Pre-School Nutrition Survey.

    PubMed

    O'Connor, Laura; Walton, Janette; Flynn, Albert

    2016-06-01

    Although the importance of fruit and vegetable (F&V) intakes in the prevention of chronic diseases is well established, there are limited data on intakes in very young children. This study estimates F&V intakes and sources and the contribution to the total diet using data from the National Pre-School Nutrition Survey, a nationally representative sample (n 500) of Irish children aged 1-4 years. A 4-d weighed food record was used to collect food intake data. Of 1652 food codes consumed, 740 had a fruit/vegetable component. The percentage of edible fruits and/or vegetables in each food code was calculated. Intakes (g/d), sources (g/d) and the contribution of F&V to the weight of the total diet (%) were estimated, split by age. All children consumed F&V. Intakes of total fruits, in particular fruit juice, increased with age. The contribution to total fruit intake was discrete fruits (47-56 % range across age), 100 % fruit juice, smoothies and pureés (32-45 %) as well as fruits in composite dishes (7-13 %). Total vegetable intake comprised of discrete vegetables (48-62 % range across age) and vegetables in composite dishes (38-52 %). F&V contributed on average 20 % (15 % fruit; 5 % vegetables) to the weight of the total diet and was <10 % in sixty-one children (12 %). F&V contributed 50 % of vitamin C, 53 % of carotene, 34 % of dietary fibre and 42 % of non-milk sugar intakes from the total diet. F&V are important components of the diet of Irish pre-school children; however, some aspects of F&V intake patterns could be improved in this age group. PMID:27102717

  16. Development of a distance education program by a Land-Grant University augments the 2-year to 4-year STEM pipeline and increases diversity in STEM.

    PubMed

    Drew, Jennifer C; Oli, Monika W; Rice, Kelly C; Ardissone, Alexandria N; Galindo-Gonzalez, Sebastian; Sacasa, Pablo R; Belmont, Heather J; Wysocki, Allen F; Rieger, Mark; Triplett, Eric W

    2015-01-01

    Although initial interest in science, technology, engineering and mathematics (STEM) is high, recruitment and retention remains a challenge, and some populations are disproportionately underrepresented in STEM fields. To address these challenges, the Microbiology and Cell Science Department in the College of Agricultural and Life Sciences at the University of Florida has developed an innovative 2+2 degree program. Typical 2+2 programs begin with a student earning an associate's degree at a local community college and then transferring to a 4-year institution to complete a bachelor's degree. However, many universities in the United States, particularly land-grant universities, are located in rural regions that are distantly located from their respective states' highly populated urban centers. This geographical and cultural distance could be an impediment to recruiting otherwise highly qualified and diverse students. Here, a new model of a 2+2 program is described that uses distance education as the vehicle to bring a research-intensive university's life sciences curriculum to students rather than the oft-tried model of a university attempting to recruit underrepresented minority students to its location. In this paradigm, community college graduates transfer into the Microbiology and Cell Science program as distance education students to complete their Bachelor of Science degree. The distance education students' experiences are similar to the on-campus students' experiences in that both groups of students take the same department courses taught by the same instructors, take required laboratory courses in a face-to-face format, take only proctored exams, and have the same availability to instructors. Data suggests that a hybrid online transfer program may be a viable approach to increasing STEM participation (as defined by enrollment) and diversity. This approach is particularly compelling as the distance education cohort has comparable grade point averages and

  17. Effects of 4 years of CO 2 enrichment on the abundance of leaf-galls and leaf-mines in mature oaks

    NASA Astrophysics Data System (ADS)

    Kampichler, Christian; Teschner, Markus; Klein, Stefan; Körner, Christian

    2008-09-01

    Since CO 2 enrichment alters the composition of live plant tissues, the ongoing global increase of atmospheric CO 2 concentration is expected to affect plant-animal interactions. Although this is a widely explored field, test systems studied so far have not included mature trees. Our study uses the Swiss Canopy Crane and the web-FACE CO 2 enrichment system in a 35 m tall temperate deciduous forest. We studied the in situ abundance of dominant leaf-galls and leaf-miners on 13 mature oaks before the treatment started, and in two sub-groups, one of which received CO 2 enrichment from 2001 to 2004. We expected that gall-inducing cynipids ( Neuroterus quercusbaccarum and N. numismalis) would show similar loads with spangle-galls on the two tree groups, due to their capacity to manipulate their host plant and the quality of gall tissues. On the other hand, we expected that leaf-miners ( Tischeria ekebladella) would show higher infestation on trees with high-quality (i.e. low C/N ratio, etc.) foliage leading to less mines on CO 2 enriched oaks. Partially in line with our hypothesis, spangle-gall density showed only a positive short-term pulse effect ( N. quercusbaccarum only) and did not differ across treatments after 4 years. In contrast to our hypothesis, the leaf-miner species did not respond persistently to CO 2 enrichment either; it even showed higher infestation on CO 2 enriched oaks in the 1st year after the onset of enrichment. In conclusion, CO 2 enrichment had no lasting effect in all three taxa, despite the substantial and consistent change in leaf chemistry of oak due to growth in elevated CO 2.

  18. LISK-BROOM: Clearing near-Earth space debris in 4 years using a 20-kW, 530-nm repetitively pulsed laser

    SciTech Connect

    Phipps, C.R.; Michaelis, M.M.

    1994-10-01

    When space debris forced a change of plan for a recent US Space Shuttle mission, it finally reached the point of broad awareness. Almost a million pieces of debris have been generated by 35 years of spaceflight, and now threaten some long-term space missions. This problem can best a be solved by causing space debris items to re-enter and burn up in the atmosphere on a computed trajectory. Illumination of the objects by a repetitively-pulsed laser will easily produce a laser-ablation jet providing the impulse to de-orbit the object. For reasons we will discuss, we propose the use of a ground-based laser system, atmospheric-turbulence compensating beam director, computer and high resolution detection system to solve this problem. A laser of just 2OkW average power and state-of-the-art detection capabilities could clear near-Earth space below 1100km altitude of all space debris larger than 1 cm but less massive than 100kg in about 4 years. The LISK-BROOM laser would be located near the Equator above 5km elevation [e.g., the Uhuru site on Kilimanjarol, minimizing turbulence correction and absorption of the 530-nm wavelength laser beam. LISK-BROOM is a special case of Laser Impulse Space Propulsion (LISP), by which objects are propelled in space by the ablation jet due to a distant laser. We will also discuss active beam phase error correction during passage through the atmosphere and the object detection system which are necessary.

  19. Development of a Distance Education Program by a Land-Grant University Augments the 2-Year to 4-Year STEM Pipeline and Increases Diversity in STEM

    PubMed Central

    Drew, Jennifer C.; Oli, Monika W.; Rice, Kelly C.; Ardissone, Alexandria N.; Galindo-Gonzalez, Sebastian; Sacasa, Pablo R.; Belmont, Heather J.; Wysocki, Allen F.; Rieger, Mark; Triplett, Eric W.

    2015-01-01

    Although initial interest in science, technology, engineering and mathematics (STEM) is high, recruitment and retention remains a challenge, and some populations are disproportionately underrepresented in STEM fields. To address these challenges, the Microbiology and Cell Science Department in the College of Agricultural and Life Sciences at the University of Florida has developed an innovative 2+2 degree program. Typical 2+2 programs begin with a student earning an associate’s degree at a local community college and then transferring to a 4-year institution to complete a bachelor’s degree. However, many universities in the United States, particularly land-grant universities, are located in rural regions that are distantly located from their respective states’ highly populated urban centers. This geographical and cultural distance could be an impediment to recruiting otherwise highly qualified and diverse students. Here, a new model of a 2+2 program is described that uses distance education as the vehicle to bring a research-intensive university’s life sciences curriculum to students rather than the oft-tried model of a university attempting to recruit underrepresented minority students to its location. In this paradigm, community college graduates transfer into the Microbiology and Cell Science program as distance education students to complete their Bachelor of Science degree. The distance education students’ experiences are similar to the on-campus students’ experiences in that both groups of students take the same department courses taught by the same instructors, take required laboratory courses in a face-to-face format, take only proctored exams, and have the same availability to instructors. Data suggests that a hybrid online transfer program may be a viable approach to increasing STEM participation (as defined by enrollment) and diversity. This approach is particularly compelling as the distance education cohort has comparable grade point

  20. Magnitude of undernutrition in children aged 2 to 4 years using CIAF and conventional indices in the slums of Mumbai city.

    PubMed

    Savanur, Mitravinda S; Ghugre, Padmini S

    2015-01-01

    Conventional indicators - weight-for-age, height-for-age, weight-for-height and mid-upper arm circumference (MUAC) reflect different facets of the nutritional status. Weight-for-age is the most commonly used indicator. When used individually or in combination, conventional indices fail to depict the overall magnitude of undernutrition in the population. Composite Index of Anthropometric Failure (CIAF) is an alternative classification system which attempts to fill this lacuna. Thus, we undertook this study with the objective to compare the prevalence of undernutrition using CIAF and the conventional indices. We included 634 children aged between 2 to 4 years from anganwadis located in three areas of Mumbai. Weight, height and MUAC measurements were taken. Z scores were computed for weight-for-age (WAZ), height-for-age (HAZ) and weight-for-height (WHZ) using WHO Anthro software. Children were classified as per the conventional indices and CIAF. The prevalence of underweight, stunting and wasting was 35.7%, 33.8% and 18.5% respectively. None of the children had MUAC < 11.5 cm. About 1% of the children were moderately wasted according to MUAC. As per CIAF, 47.8% children were undernourished. According to CIAF, one-third of the undernourished children had single anthropometric failure while half of them had dual failure and 17.1% had multiple failures. When compared with the conventional indices, CIAF could recognize 12.1%, 14.0%, 29.3% and 46.7% more undernourished children than WAZ, HAZ, WHZ and MUAC respectively. In conclusion, CIAF is seen to have many advantages over the conventional indices. CIAF is useful in assessing the overall magnitude of undernutrition and identifying children with multiple anthropometric failures. It also recognizes more undernourished children than all the conventional indices. Therefore, CIAF should be used more widely as a tool for nutritional assessment particularly in developing countries where the burden of undernutrition is high