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  1. The 40th AAAS Gordon Conference on nuclear chemistry

    SciTech Connect

    Seaborg, G.T.

    1991-06-27

    I am pleased to speak at the Fortieth Gordon Conference on Nuclear Chemistry. I served as Chairman of the first Gordon Conference on Nuclear Chemistry held June 23--27, 1952, at New Hampton, New Hampshire. In my remarks, during which I shall quote from my journal, I shall describe some of the background leading up to the first Gordon Conference on Nuclear Chemistry and my attendance at the first seven Gordon Conferences during the period 1952 through 1958. I shall also quote my description of my appearance as the featured speaker at the Silver Anniversary of the Gordon Research Conferences on December 27, 1956 held at the Commodore Hotel in New York City. I shall begin with reference to my participation in the predecessor to the Gordon Conferences, the Gibson Island Research Conferences 45 years ago, on Thursday, June 20, 1946, as a speaker. This was 15 years after the start of these conferences in 1931. Neil Gordon played a leading role in these conferences, which were named (in 1948) in his honor -- the Gordon Research Conferences -- soon after they were moved to Colby Junior College, New London, New Hampshire in 1947. W. George Parks became Director in 1947, Alexander Cruickshank became Assistant Director in 1947 and Director in 1968.

  2. Abdominal Aortic Aneurysm (AAA)

    MedlinePlus

    ... Resources Professions Site Index A-Z Abdominal Aortic Aneurysm (AAA) Abdominal aortic aneurysm (AAA) occurs when atherosclerosis ... aortic aneurysm treated? What is an abdominal aortic aneurysm? The aorta, the largest artery in the body, ...

  3. AAAS: Politics. . . and Science

    ERIC Educational Resources Information Center

    Science News, 1978

    1978-01-01

    Reviews topics discussed during the American Association for the Advancement of Science (AAAS) meeting held in Washington, D.C. Topics included: the equal rights amendment, laetrile, nuclear radiation hazards, sociobiology, and various science topics. (SL)

  4. Science Education at AAAS

    ERIC Educational Resources Information Center

    Livermore, Arthur H.

    1975-01-01

    Describes several programs of the American Association for the Advancement of Science (AAAS) Office of Science Education (OSE), including short courses offered in the natural and social sciences, mathematics, and engineering to college teachers. Discusses several OSE publications. (MLH)

  5. The First Reactor, 40th Anniversary (rev.)

    SciTech Connect

    Allardice, Corbin; Trapnell, Edward R; Fermi, Enrico; Fermi, Laura; Williams, Robert C

    1982-12-01

    This booklet, an updated version of the original booklet describing the first nuclear reactor, was written in honor of the 40th anniversary of the first reactor or "pile". It is based on firsthand accounts told to Corbin Allardice and Edward R. Trapnell, and includes recollections of Enrico and Laura Fermi.

  6. AAA Foundation for Traffic Safety

    MedlinePlus

    ... Survey: Teens should be wired less while driving, AAA Arizona says ... - ABC15 Arizona Graduated Licensing Laws - Insurance ... of Top Deadly Mistakes Made by Teen Drivers -- AAA More... Spotlight American Driving Survey This survey provides ...

  7. ESO's First Observatory Celebrates 40th Anniversary

    NASA Astrophysics Data System (ADS)

    2009-03-01

    ESO's La Silla Observatory, which is celebrating its 40th anniversary, became the largest astronomical observatory of its time. It led Europe to the frontline of astronomical research, and is still one of the most scientifically productive in ground-based astronomy. ESO PR Photo 12a/09 La Silla Aerial View ESO PR Photo 12b/09 The ESO New Technology Telescope ESO PR Photo 12c/09 SEST on La Silla ESO PR Photo 12d/09 Looking for the best site ESO PR Video 12a/09 ESOcast 5 With about 300 refereed publications attributable to the work of the observatory per year, La Silla remains at the forefront of astronomy. It has led to an enormous number of scientific discoveries, including several "firsts". The HARPS spectrograph is the world's foremost exoplanet hunter. It detected the system around Gliese 581, which contains what may be the first known rocky planet in a habitable zone, outside the Solar System (ESO 22/07). Several telescopes at La Silla played a crucial role in discovering that the expansion of the Universe is accelerating (ESO 21/98) and in linking gamma-ray bursts -- the most energetic explosions in the Universe since the Big Bang - with the explosions of massive stars (ESO 15/98). Since 1987, the ESO La Silla Observatory has also played an important role in the study and follow-up of the nearest supernova, SN 1987A (ESO 08/07). "The La Silla Observatory continues to offer the astronomical community exceptional capabilities," says ESO Director General, Tim de Zeeuw. "It was ESO's first presence in Chile and as such, it triggered a very long and fruitful collaboration with this country and its scientific community." The La Silla Observatory is located at the edge of the Chilean Atacama Desert, one of the driest and loneliest areas of the world. Like other observatories in this geographical area, La Silla is located far from sources of polluting light and, as the Paranal Observatory that houses the Very Large Telescope, it has one of the darkest and clearest

  8. Universal Declaration of Human Rights: 40th Anniversary.

    ERIC Educational Resources Information Center

    Adams, Juanita, Ed.

    December 10, 1988, marks the 40th anniversary of the adoption by the United Nations of the Universal Declaration of Human Rights. The Declaration represents the first comprehensive, global statement on basic human rights, embracing many of the values long held by U.S. citizens; and it urges all peoples and all nations to promote respect for the…

  9. Gordon Becomes a Hurricane, Weakens

    NASA Video Gallery

    In this animation of satellite observations from August 17-20, 2012, Tropical Storm Gordon strengthens into a hurricane as an eye became visible on Aug. 18 just before Gordon affected the Azores Is...

  10. Obituary: Gordon Donaldson Obituary: Gordon Donaldson

    NASA Astrophysics Data System (ADS)

    Pegrum, Colin; Campbell, Archie; Hampshire, Damian

    2013-07-01

    Gordon Donaldson died in Glasgow on 28 November 2012 at the age of 71. He was born in Edinburgh and brought up and educated in Glasgow, which was his home city for much of his life. He was educated first at Glasgow Academy, and then with a scholarship at Christ's College Cambridge. Here he read Natural Sciences, finishing with first class honors in Physics. He then did a PhD on tunneling in superconductors in the Mond Laboratory, supervised by John Adkins. These were interesting times, since type II superconductors had only recently been identified, and the Mond was a leading player in the physics of vortices and other quantum effects. It was headed by Pippard and Shoenberg, and colleagues around that time were Brian Josephson, John Clarke, Colin Gough and John Waldram. On finishing his PhD in 1966 Gordon went straight to a lectureship at the University of Lancaster. In 1975 during a sabbatical at the University of California, Berkeley, with John Clarke's group, Gordon co-invented thin-film gradiometers with integrated DC SQUIDs. He then moved back to Glasgow, to the Department of Applied Physics at Strathclyde University, where he founded a new research group to make and use superconducting devices, especially SQUIDs and gradiometers. From modest beginnings the group grew steadily, acquiring new facilities and members, until in the 1990s it had over 20 members and a host of collaborators from elsewhere in Glasgow and abroad. With funding from the Wellcome Trust, Gordon and colleagues at Glasgow University and the Southern General Hospital in Glasgow set up a new biomagnetism facility in 1998 on the hospital campus to use SQUID gradiometers made at Strathclyde for measurements on patients and volunteers. Another of his main research interests was the use of SQUIDs for nondestructive evaluation (NDE). This started in the days before high temperature superconductors (HTS) with wire-wound gradiometers and niobium SQUIDs, soon moving on to miniature thin-film niobium

  11. The first reactor [40th anniversary commemorative edition

    SciTech Connect

    1982-12-01

    This updated and revised story of the first reactor, or 'pile,' commemorates the 40th anniversary of the first controlled, self-sustaining nuclear chain reaction created by mankind. Enrico Fermi and his team of scientists initiated the reaction on December 2, 1941, underneath the West Stands of Stagg Field at the University of Chicago. Firsthand accounts of the participants as well as postwar recollections by Enrico and Laura Fermi are included.

  12. The First Reactor [40th Anniversary Commemorative Edition].

    DOE R&D Accomplishments Database

    1982-12-01

    This updated and revised story of the first reactor, or 'pile,' commemorates the 40th anniversary of the first controlled, self-sustaining nuclear chain reaction created by mankind. Enrico Fermi and his team of scientists initiated the reaction on December 2, 1941, underneath the West Stands of Stagg Field at the University of Chicago. Firsthand accounts of the participants as well as postwar recollections by Enrico and Laura Fermi are included.

  13. Obituary: Gordon Donaldson Obituary: Gordon Donaldson

    NASA Astrophysics Data System (ADS)

    Pegrum, Colin; Campbell, Archie; Hampshire, Damian

    2013-07-01

    Gordon Donaldson died in Glasgow on 28 November 2012 at the age of 71. He was born in Edinburgh and brought up and educated in Glasgow, which was his home city for much of his life. He was educated first at Glasgow Academy, and then with a scholarship at Christ's College Cambridge. Here he read Natural Sciences, finishing with first class honors in Physics. He then did a PhD on tunneling in superconductors in the Mond Laboratory, supervised by John Adkins. These were interesting times, since type II superconductors had only recently been identified, and the Mond was a leading player in the physics of vortices and other quantum effects. It was headed by Pippard and Shoenberg, and colleagues around that time were Brian Josephson, John Clarke, Colin Gough and John Waldram. On finishing his PhD in 1966 Gordon went straight to a lectureship at the University of Lancaster. In 1975 during a sabbatical at the University of California, Berkeley, with John Clarke's group, Gordon co-invented thin-film gradiometers with integrated DC SQUIDs. He then moved back to Glasgow, to the Department of Applied Physics at Strathclyde University, where he founded a new research group to make and use superconducting devices, especially SQUIDs and gradiometers. From modest beginnings the group grew steadily, acquiring new facilities and members, until in the 1990s it had over 20 members and a host of collaborators from elsewhere in Glasgow and abroad. With funding from the Wellcome Trust, Gordon and colleagues at Glasgow University and the Southern General Hospital in Glasgow set up a new biomagnetism facility in 1998 on the hospital campus to use SQUID gradiometers made at Strathclyde for measurements on patients and volunteers. Another of his main research interests was the use of SQUIDs for nondestructive evaluation (NDE). This started in the days before high temperature superconductors (HTS) with wire-wound gradiometers and niobium SQUIDs, soon moving on to miniature thin-film niobium

  14. Proceedings of the 40th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Littlefield, Alan C.; Mueller, Robert P.; Boesiger, Edward A. (Editor)

    2010-01-01

    The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development and flight certification of new mechanisms. Organized by the Mechanisms Education Association, responsibility for hosting the AMS is shared by the National Aeronautics and Space Administration and Lockheed Martin Space Systems Company (LMSSC). Now in its 40th symposium, the AMS continues to be well attended, attracting participants from both the U.S. and abroad. The 40th AMS, hosted by the Kennedy Space Center (KSC) in Cocoa Beach, Florida, was held May 12, 13 and 14, 2010. During these three days, 38 papers were presented. Topics included gimbals and positioning mechanisms, CubeSats, actuators, Mars rovers, and Space Station mechanisms. Hardware displays during the supplier exhibit gave attendees an opportunity to meet with developers of current and future mechanism components. The use of trade names of manufacturers in this publication does not constitute an official endorsement of such products or manufacturers, either expressed or implied, by the National Aeronautics and Space Administration

  15. Reflections on the Gordon Commission

    ERIC Educational Resources Information Center

    Haertel, Edward

    2014-01-01

    Background:This brief reflection on the work of the Gordon Commission calls out significant themes and implications found in the various papers authored by the commissioners and other scholars, especially those included in this special issue of Teachers College Record. Purpose: The forward-looking vision of the Gordon Commission is contrasted with…

  16. Genetic analysis of abdominal aortic aneurysms (AAA)

    SciTech Connect

    St. Jean, P.L.; Hart, B.K.; Zhang, X.C.

    1994-09-01

    The association between AAA and gender, smoking (SM), hypertension (HTN) and inguinal herniation (IH) was examined in 141 AAA probands and 139 of their 1st degree relatives with aortic exam (36 affected, 103 unaffected). There was no significant difference between age at diagnosis of affecteds and age at exam of unaffecteds. Of 181 males, 142 had AAA; of 99 females, 35 had AAA. Using log-linear modeling AAA was significantly associated at the 5% level with gender, SM and HTN but not IH. The association of AAA with SM and HTN held when males and females were analyzed separately. HTN was -1.5 times more common in both affected males and females, while SM was 1.5 and 2 times more common in affected males and females, respectively. Tests of association and linkage analyses were performed with relevant candidate genes: 3 COL3A1 polymorphisms (C/T, ALA/THR, AvaII), 2 ELN polymorphisms (SER/GLY, (CA)n), FBN1(TAAA)n, 2 APOB polymorphisms (Xbal,Ins/Del), CLB4B (CA)n, PI and markers D1S243 (CA)n, HPR (CA)n and MFD23(CA)n. The loci were genotyped in > 100 AAA probands and > 95 normal controls. No statistically significant evidence of association at the 5% level was obtained for any of the loci using chi-square test of association. 28 families with 2 or more affecteds were analyzed using the affected pedigree member method (APM) and lod-score analyses. There was no evidence for linkage with any loci using APM. Lod-score analysis under an autosomal recessive model resulted in excluding linkage (lod score < -2) of all loci to AAA at {theta}=0.0. Under an autosomal dominant model, linkage was excluded at {theta}=0.0 to ELN, APOB, CLG4B, D1S243, HPR and MFD23. The various genes previously proposed in AAA pathogenesis are neither associated nor casually related in our study population.

  17. Pathophysiology of AAA: heredity vs environment.

    PubMed

    Björck, Martin; Wanhainen, Anders

    2013-01-01

    Abdominal aortic aneurysm (AAA) has a complex pathophysiology, in which both environmental and genetic factors play important roles, the most important being smoking. The recently reported falling prevalence rates of AAA in northern Europe and Australia/New Zeeland are largely explained by healthier smoking habits. Dietary factors and obesity, in particular abdominal obesity, are also of importance. A family history of AAA among first-degree relatives is present in approximately 13% of incident cases. The probability that a monozygotic twin of a person with an AAA has the disease is 24%, 71 times higher than that for a monozygotic twin of a person without AAA. Approximately 1000 SNPs in 100 candidate genes have been studied, and three genome-wide association studies were published, identifying different diverse weak associations. An example of interaction between environmental and genetic factors is the effect of cholesterol, where genetic and dietary factors affect levels of both HDL and LDL. True epigenetic studies have not yet been published.

  18. Sequence analysis of the AAA protein family.

    PubMed Central

    Beyer, A.

    1997-01-01

    The AAA protein family, a recently recognized group of Walker-type ATPases, has been subjected to an extensive sequence analysis. Multiple sequence alignments revealed the existence of a region of sequence similarity, the so-called AAA cassette. The borders of this cassette were localized and within it, three boxes of a high degree of conservation were identified. Two of these boxes could be assigned to substantial parts of the ATP binding site (namely, to Walker motifs A and B); the third may be a portion of the catalytic center. Phylogenetic trees were calculated to obtain insights into the evolutionary history of the family. Subfamilies with varying degrees of intra-relatedness could be discriminated; these relationships are also supported by analysis of sequences outside the canonical AAA boxes: within the cassette are regions that are strongly conserved within each subfamily, whereas little or even no similarity between different subfamilies can be observed. These regions are well suited to define fingerprints for subfamilies. A secondary structure prediction utilizing all available sequence information was performed and the result was fitted to the general 3D structure of a Walker A/GTPase. The agreement was unexpectedly high and strongly supports the conclusion that the AAA family belongs to the Walker superfamily of A/GTPases. PMID:9336829

  19. 26 CFR 1.1368-2 - Accumulated adjustments account (AAA).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Accumulated adjustments account (AAA). 1.1368-2... adjustments account (AAA). (a) Accumulated adjustments account—(1) In general. The accumulated adjustments account is an account of the S corporation and is not apportioned among shareholders. The AAA is...

  20. District Energy Corporation SW 40th Street Thermal Energy Plant

    SciTech Connect

    Davlin, Thomas

    2014-06-06

    The overall deliverable from the project is the design, construction and commissioning of a detention facility heating and cooling system that minimizes ownership costs and maximizes efficiency (and therefore minimizes environmental impact). The primary deliverables were the proof of concept for the application of geothermal systems for an institutional facility and the ongoing, quarterly system operating data downloads to the Department of Energy . The primary advantage of geothermal based heat pump systems is the higher efficiency of the system compared to a conventional chiller, boiler, cooling tower based system. The higher efficiency results in a smaller environmental foot print and lower energy costs for the detention facility owner, Lancaster County. The higher efficiency for building cooling is primarily due to a more constant compressor condensing temperature with the geothermal well field acting as a thermal “sink” (in place of the conventional system’s cooling tower). In the heating mode, Ground Couple Heat Pump (GCHP) systems benefits from the advantage of a heat pump Coefficient of Performance (COP) of approximately 3.6, significantly better than a conventional gas boiler. The geothermal well field acting as a thermal “source” allows the heat pumps to operate efficiently in the heating mode regardless of ambient temperatures. The well field is partially located in a wetland with a high water table so, over time, the project will be able to identify the thermal loading characteristics of a well field located in a high water table location. The project demonstrated how a large geothermal well field can be installed in a wetland area in an economical and environmentally sound manner. Finally, the SW 40th Street Thermal Energy Plant project demonstrates the benefits of providing domestic hot water energy, as well as space heating, to help balance well filed thermal loading in a cooling dominated application. During the period of August 2012 thru

  1. Proceedings of the 40th Lunar and Planetary Science Conference

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The 40th Lunar and Planetary Science Conference included sessions on: Phoenix: Exploration of the Martian Arctic; Origin and Early Evolution of the Moon; Comet Wild 2: Mineralogy and More; Astrobiology: Meteorites, Microbes, Hydrous Habitats, and Irradiated Ices; Phoenix: Soil, Chemistry, and Habitability; Planetary Differentiation; Presolar Grains: Structures and Origins; SPECIAL SESSION: Venus Atmosphere: Venus Express and Future Missions; Mars Polar Caps: Past and Present; SPECIAL SESSION: Lunar Missions: Results from Kaguya, Chang'e-1, and Chandrayaan-1, Part I; 5 Early Nebula Processes and Models; SPECIAL SESSION: Icy Satellites of Jupiter and Saturn: Cosmic Gymnasts; Mars: Ground Ice and Climate Change; SPECIAL SESSION: Lunar Missions: Results from Kaguya, Chang'e-1, and Chandrayaan-1, Part II; Chondrite Parent-Body Processes; SPECIAL SESSION: Icy Satellites of Jupiter and Saturn: Salubrious Surfaces; SNC Meteorites; Ancient Martian Crust: Primary Mineralogy and Aqueous Alteration; SPECIAL SESSION: Messenger at Mercury: A Global Perspective on the Innermost Planet; CAIs and Chondrules: Records of Early Solar System Processes; Small Bodies: Shapes of Things to Come; Sulfur on Mars: Rocks, Soils, and Cycling Processes; Mercury: Evolution and Tectonics; Venus Geology, Volcanism, Tectonics, and Resurfacing; Asteroid-Meteorite Connections; Impacts I: Models and Experiments; Solar Wind and Genesis: Measurements and Interpretation; Mars: Aqueous Processes; Magmatic Volatiles and Eruptive Conditions of Lunar Basalts; Comparative Planetology; Interstellar Matter: Origins and Relationships; Impacts II: Craters and Ejecta Mars: Tectonics and Dynamics; Mars Analogs I: Geological; Exploring the Diversity of Lunar Lithologies with Sample Analyses and Remote Sensing; Chondrite Accretion and Early History; Science Instruments for the Mars Science Lander; . Martian Gullies: Morphology and Origins; Mars: Dunes, Dust, and Wind; Mars: Volcanism; Early Solar System Chronology

  2. AAA-DDD triple hydrogen bond complexes.

    PubMed

    Blight, Barry A; Camara-Campos, Amaya; Djurdjevic, Smilja; Kaller, Martin; Leigh, David A; McMillan, Fiona M; McNab, Hamish; Slawin, Alexandra M Z

    2009-10-01

    Experiment and theory both suggest that the AAA-DDD pattern of hydrogen bond acceptors (A) and donors (D) is the arrangement of three contiguous hydrogen bonding centers that results in the strongest association between two species. Murray and Zimmerman prepared the first example of such a system (complex 3*2) and determined the lower limit of its association constant (K(a)) in CDCl(3) to be 10(5) M(-1) by (1)H NMR spectroscopy (Murray, T. J. and Zimmerman, S. C. J. Am. Chem. Soc. 1992, 114, 4010-4011). The first cationic AAA-DDD pair (3*4(+)) was described by Bell and Anslyn (Bell, D. A. and Anslyn, E. A. Tetrahedron 1995, 51, 7161-7172), with a K(a) > 5 x 10(5) M(-1) in CH(2)Cl(2) as determined by UV-vis spectroscopy. We were recently able to quantify the strength of a neutral AAA-DDD arrangement using a more chemically stable AAA-DDD system, 6*2, which has an association constant of 2 x 10(7) M(-1) in CH(2)Cl(2) (Djurdjevic, S., Leigh, D. A., McNab, H., Parsons, S., Teobaldi, G. and Zerbetto, F. J. Am. Chem. Soc. 2007, 129, 476-477). Here we report on further AA(A) and DDD partners, together with the first precise measurement of the association constant of a cationic AAA-DDD species. Complex 6*10(+)[B(3,5-(CF(3))(2)C(6)H(3))(4)(-)] has a K(a) = 3 x 10(10) M(-1) at RT in CH(2)Cl(2), by far the most strongly bound triple hydrogen bonded system measured to date. The X-ray crystal structure of 6*10(+) with a BPh(4)(-) counteranion shows a planar array of three short (NH...N distances 1.95-2.15 A), parallel (but staggered rather than strictly linear; N-H...N angles 165.4-168.8 degrees), primary hydrogen bonds. These are apparently reinforced, as theory predicts, by close electrostatic interactions (NH-*-N distances 2.78-3.29 A) between each proton and the acceptor atoms of the adjacent primary hydrogen bonds.

  3. Proceedings of the 40th Lunar and Planetary Science Conference

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The 40th Lunar and Planetary Science Conference included sessions on: Phoenix: Exploration of the Martian Arctic; Origin and Early Evolution of the Moon; Comet Wild 2: Mineralogy and More; Astrobiology: Meteorites, Microbes, Hydrous Habitats, and Irradiated Ices; Phoenix: Soil, Chemistry, and Habitability; Planetary Differentiation; Presolar Grains: Structures and Origins; SPECIAL SESSION: Venus Atmosphere: Venus Express and Future Missions; Mars Polar Caps: Past and Present; SPECIAL SESSION: Lunar Missions: Results from Kaguya, Chang'e-1, and Chandrayaan-1, Part I; 5 Early Nebula Processes and Models; SPECIAL SESSION: Icy Satellites of Jupiter and Saturn: Cosmic Gymnasts; Mars: Ground Ice and Climate Change; SPECIAL SESSION: Lunar Missions: Results from Kaguya, Chang'e-1, and Chandrayaan-1, Part II; Chondrite Parent-Body Processes; SPECIAL SESSION: Icy Satellites of Jupiter and Saturn: Salubrious Surfaces; SNC Meteorites; Ancient Martian Crust: Primary Mineralogy and Aqueous Alteration; SPECIAL SESSION: Messenger at Mercury: A Global Perspective on the Innermost Planet; CAIs and Chondrules: Records of Early Solar System Processes; Small Bodies: Shapes of Things to Come; Sulfur on Mars: Rocks, Soils, and Cycling Processes; Mercury: Evolution and Tectonics; Venus Geology, Volcanism, Tectonics, and Resurfacing; Asteroid-Meteorite Connections; Impacts I: Models and Experiments; Solar Wind and Genesis: Measurements and Interpretation; Mars: Aqueous Processes; Magmatic Volatiles and Eruptive Conditions of Lunar Basalts; Comparative Planetology; Interstellar Matter: Origins and Relationships; Impacts II: Craters and Ejecta Mars: Tectonics and Dynamics; Mars Analogs I: Geological; Exploring the Diversity of Lunar Lithologies with Sample Analyses and Remote Sensing; Chondrite Accretion and Early History; Science Instruments for the Mars Science Lander; . Martian Gullies: Morphology and Origins; Mars: Dunes, Dust, and Wind; Mars: Volcanism; Early Solar System Chronology

  4. Astronaut Gordon Cooper After Recovery

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut Gordon Cooper leaves the Faith 7 (MA-9) spacecraft after a successful recovery operation. The MA-9 mission, the last flight of the Mercury Project, was launched on May 15, 1963, orbited the Earth 22 times, and lasted for 1-1/2 days.

  5. C. Gordon Fullerton

    NASA Technical Reports Server (NTRS)

    1989-01-01

    C. Gordon Fullerton is a research pilot at NASA's Dryden Flight Research Center, Edwards, California. His assignments include a variety of flight research and support activities piloting NASA's B-52 launch aircraft, the 747 Shuttle Carrier Aircraft (SCA), and other multi-engine and high performance aircraft. Fullerton, who has logged 382 hours in space flight, was a NASA astronaut from September 1969 until November 1986 when he joined the Flight Crew Branch at Dryden. In July 1988, he completed a 30-year career with the U.S. Air Force and retired as a colonel. As the project pilot on the NASA B-52 launch aircraft, Fullerton flew during the first six air launches of the commercially developed Pegasus space vehicle. He was involved in a series of development air launches of the X-38 Crew Recovery Vehicle and in the Pegasus launch of the X-43A Hyper-X advanced propulsion project. Fullerton also flies Dryden's DC-8 Airborne Science aircraft, regularly deployed worldwide to support a variety of research studies, including atmospheric physics, ground mapping and meteorology. In addition to these current activities, Fullerton has been involved in numerous other research programs at Dryden. He was the project pilot on the Propulsion Controlled Aircraft program, during which he successfully landed both a modified F-15 and an MD-11 transport with all control surfaces neutralized, using only engine thrust modulation for control. Assigned to evaluate the flying qualities of the Russian Tu-144 supersonic transport during two flights in 1998, he reached a speed of Mach 2 and became one of only two non-Russian pilots to fly that aircraft. He piloted a Convair 990 modified to test space shuttle landing gear components during many very high-speed landings. Other projects for which he has flown in the past include the C-140 JetStar Laminar Flow Control; F-111 Mission Adaptive Wing; F-14 Variable Sweep Flow Transition; Space Shuttle drag chute and F-111 crew module parachute tests

  6. C. Gordon Fullerton

    NASA Technical Reports Server (NTRS)

    1989-01-01

    C. Gordon Fullerton is a research pilot at NASA's Dryden Flight Research Center, Edwards, California. His assignments include a variety of flight research and support activities piloting NASA's B-52 launch aircraft, the 747 Shuttle Carrier Aircraft (SCA), and other multi-engine and high performance aircraft. Fullerton, who has logged 382 hours in space flight, was a NASA astronaut from September 1969 until November 1986 when he joined the Flight Crew Branch at Dryden. In July 1988, he completed a 30-year career with the U.S. Air Force and retired as a colonel. As the project pilot on the NASA B-52 launch aircraft, Fullerton flew during the first six air launches of the commercially developed Pegasus space vehicle. He was involved in a series of development air launches of the X-38 Crew Recovery Vehicle and in the Pegasus launch of the X-43A Hyper-X advanced propulsion project. Fullerton also flies Dryden's DC-8 Airborne Science aircraft, regularly deployed worldwide to support a variety of research studies, including atmospheric physics, ground mapping and meteorology. In addition to these current activities, Fullerton has been involved in numerous other research programs at Dryden. He was the project pilot on the Propulsion Controlled Aircraft program, during which he successfully landed both a modified F-15 and an MD-11 transport with all control surfaces neutralized, using only engine thrust modulation for control. Assigned to evaluate the flying qualities of the Russian Tu-144 supersonic transport during two flights in 1998, he reached a speed of Mach 2 and became one of only two non-Russian pilots to fly that aircraft. He piloted a Convair 990 modified to test space shuttle landing gear components during many very high-speed landings. Other projects for which he has flown in the past include the C-140 JetStar Laminar Flow Control; F-111 Mission Adaptive Wing; F-14 Variable Sweep Flow Transition; Space Shuttle drag chute and F-111 crew module parachute tests

  7. 1993 Gordon Bell Prize Winners

    NASA Technical Reports Server (NTRS)

    Karp, Alan H.; Simon, Horst; Heller, Don; Cooper, D. M. (Technical Monitor)

    1994-01-01

    The Gordon Bell Prize recognizes significant achievements in the application of supercomputers to scientific and engineering problems. In 1993, finalists were named for work in three categories: (1) Performance, which recognizes those who solved a real problem in the quickest elapsed time. (2) Price/performance, which encourages the development of cost-effective supercomputing. (3) Compiler-generated speedup, which measures how well compiler writers are facilitating the programming of parallel processors. The winners were announced November 17 at the Supercomputing 93 conference in Portland, Oregon. Gordon Bell, an independent consultant in Los Altos, California, is sponsoring $2,000 in prizes each year for 10 years to promote practical parallel processing research. This is the sixth year of the prize, which Computer administers. Something unprecedented in Gordon Bell Prize competition occurred this year: A computer manufacturer was singled out for recognition. Nine entries reporting results obtained on the Cray C90 were received, seven of the submissions orchestrated by Cray Research. Although none of these entries showed sufficiently high performance to win outright, the judges were impressed by the breadth of applications that ran well on this machine, all nine running at more than a third of the peak performance of the machine.

  8. CAEL 2014 Forum and News: The Big 40th Anniversary Edition

    ERIC Educational Resources Information Center

    Bamford-Rees, Diana, Ed.; Doyle, Beth, Ed.; Klein-Collins, Becky, Ed.; Wertheim, Judith, Ed.

    2014-01-01

    The Council for Adult and Experiential Learning's (CAEL's) 40th anniversary year provided an opportunity for the "Forum and News" to examine the world of the adult learner from multiple perspectives and to invite CAEL friends and supporters to reflect on the evolution of the field and of CAEL as an organization. This publication presents…

  9. 75 FR 23222 - National Poultry Improvement Plan; General Conference Committee Meeting and 40th Biennial Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ... Animal and Plant Health Inspection Service National Poultry Improvement Plan; General Conference... of the National Poultry Improvement Plan (NPIP) and the NPIP's 40th Biennial Conference. DATES: The.... Andrew R. Rhorer, Senior Coordinator, National Poultry Improvement Plan, VS, APHIS, 1498 Klondike...

  10. Chickamauga National Military Park Tour Roads, Gordon's Slough Bridge, At ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Chickamauga National Military Park Tour Roads, Gordon's Slough Bridge, At the confluence of Alexander's Bridge Road and Gordon's Slough, southeast of Alexander's Bridge, Fort Oglethorpe, Catoosa County, GA

  11. Integrated Control of Axonemal Dynein AAA+ Motors

    PubMed Central

    King, Stephen M.

    2012-01-01

    Axonemal dyneins are AAA+ enzymes that convert ATP hydrolysis to mechanical work. This leads to the sliding of doublet microtubules with respect to each other and ultimately the generation of ciliary/flagellar beating. However, in order for useful work to be generated, the action of individual dynein motors must be precisely controlled. In addition, cells modulate the motility of these organelles through a variety of second messenger systems and these signals too must be integrated by the dynein motors to yield an appropriate output. This review describes the current status of efforts to understand dynein control mechanisms and their connectivity focusing mainly on studies of the outer dynein arm from axonemes of the unicellular biflagellate green alga Chlamydomonas. PMID:22406539

  12. AAAS Communicating Science Program: Reflections on Evaluation

    NASA Astrophysics Data System (ADS)

    Braha, J.

    2015-12-01

    The AAAS Center for Public Engagement (Center) with science builds capacity for scientists to engage public audiences by fostering collaboration among natural or physical scientists, communication researchers, and public engagement practitioners. The recently launched Leshner Leadership Institute empowers cohorts of mid-career scientists to lead public engagement by supporting their networks of scientists, researchers, and practitioners. The Center works closely with social scientists whose research addresses science communication and public engagement with science to ensure that the Communicating Science training program builds on empirical evidence to inform best practices. Researchers ( Besley, Dudo, & Storkdieck 2015) have helped Center staff and an external evaluator develop pan instrument that measures progress towards goals that are suggested by the researcher, including internal efficacy (increasing scientists' communication skills and confidence in their ability to engage with the public) and external efficacy (scientists' confidence in engagement methods). Evaluation results from one year of the Communicating Science program suggest that the model of training yields positive results that support scientists in the area that should lead to greater engagement. This talk will explore the model for training, which provides a context for strategic communication, as well as the practical factors, such as time, access to public engagement practitioners, and technical skill, that seems to contribute to increased willingness to engage with public audiences. The evaluation program results suggest willingness by training participants to engage directly or to take preliminary steps towards engagement. In the evaluation results, 38% of trained scientists reported time as a barrier to engagement; 35% reported concern that engagement would distract from their work as a barrier. AAAS works to improve practitioner-researcher-scientist networks to overcome such barriers.

  13. Fundamental Characteristics of AAA+ Protein Family Structure and Function

    PubMed Central

    2016-01-01

    Many complex cellular events depend on multiprotein complexes known as molecular machines to efficiently couple the energy derived from adenosine triphosphate hydrolysis to the generation of mechanical force. Members of the AAA+ ATPase superfamily (ATPases Associated with various cellular Activities) are critical components of many molecular machines. AAA+ proteins are defined by conserved modules that precisely position the active site elements of two adjacent subunits to catalyze ATP hydrolysis. In many cases, AAA+ proteins form a ring structure that translocates a polymeric substrate through the central channel using specialized loops that project into the central channel. We discuss the major features of AAA+ protein structure and function with an emphasis on pivotal aspects elucidated with archaeal proteins. PMID:27703410

  14. What happens to linear properties as we move from the Klein-Gordon equation to the sine-Gordon equation

    SciTech Connect

    Kovalyov, Mikhail

    2010-06-15

    In this article the sets of solutions of the sine-Gordon equation and its linearization the Klein-Gordon equation are discussed and compared. It is shown that the set of solutions of the sine-Gordon equation possesses a richer structure which partly disappears during linearization. Just like the solutions of the Klein-Gordon equation satisfy the linear superposition principle, the solutions of the sine-Gordon equation satisfy a nonlinear superposition principle.

  15. Satellite Sees Birth of Tropical Storm Gordon

    NASA Video Gallery

    An animation of satellite observations from August 13-16, 2012, shows the birth of the Atlantic Ocean hurricane season's eighth tropical depression that strengthens into Tropical Storm Gordon. This...

  16. Portrait of Astronaut Richard F. Gordon Jr.

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Portrait of Astronaut Richard F. Gordon Jr., Prime Crew Command Module Pilot of the Apollo 12 Lunar Landing Mission, in his space suit minus the helmet. He is standing outside beside a mock-up of the Lunar Lander.

  17. Inhibitors of the AAA+ Chaperone p97

    PubMed Central

    Chapman, Eli; Maksim, Nick; de la Cruz, Fabian; La Clair, James J.

    2015-01-01

    It is remarkable that a pathway as ubiquitous as protein quality control can be targeted to treat cancer. Bortezomib, an inhibitor of the proteasome, was first approved by the US Food and Drug Administration (FDA) more than 10 years ago to treat refractory myeloma and later extended to lymphoma. Its use has increased the survival rate of myeloma patients by as much as three years. This success was followed with the recent accelerated approval of the natural product derived proteasome inhibitor carfilzomib (Kyprolis®), which is used to treat patients with bortezomib-resistant multiple myeloma. The success of these two drugs has validated protein quality control as a viable target to fight select cancers, but begs the question why are proteasome inhibitors limited to lymphoma and myeloma? More recently, these limitations have encouraged the search for additional targets within the protein quality control system that might offer heightened cancer cell specificity, enhanced clinical utility, a lower rate of resistance, reduced toxicity, and mitigated side effects. One promising target is p97, an ATPase associated with various cellular activities (AAA+) chaperone. p97 figures prominently in protein quality control as well as serving a variety of other cellular functions associated with cancer. More than a decade ago, it was determined that up-regulation of p97 in many forms of cancer correlates with a poor clinical outcome. Since these initial discoveries, a mechanistic explanation for this observation has been partially illuminated, but details are lacking. Understandably, given this clinical correlation, myriad roles within the cell, and its importance in protein quality control, p97 has emerged as a potential therapeutic target. This review provides an overview of efforts towards the discovery of small molecule inhibitors of p97, offering a synopsis of efforts that parallel the excellent reviews that currently exist on p97 structure, function, and physiology. PMID

  18. Neurognostics question. Gordon Morgan Holmes.

    PubMed

    Fine, Edward J; Mehta, Bijal; Lohr, Linda A

    2011-04-01

    Gordon Morgan Holmes, MD, MRCP was an Irish born neurologist who received his medical education at Trinity College, Dublin, Ireland. He was trained in neuroanatomy and neuropathology at the Senckenberg Institute, Frankfort-Am-Main by Ludwig Edinger. He then returned to serve as a Registrar (House Officer) mentored by Richard Gowers and John Hughlings Jackson at the National Hospital, Queen Square, London. He collaborated with Thomas Granger Stewart in describing the loss of recoil in patients with cerebellar hemispheric tumors in 1904. Volunteering in 1914 for frontline hospital duty, he examined soldiers who had injuries to their occipital area causing hypotonia, dysmetria, staggering gait, and falling to the side ipsilateral to their injured cerebellar hemisphere. Holmes discovered that increasing the pace of the finger-nose manuever and applying slight resistance to a moving limb attenuated the dysmetria. Continuing observation of these patients afforded him to describe the evolution of their injuries to include increasing tremor and decreasing hypotonia. Holmes first attached levers to the limbs of hispatients to record their movements on a moving smoked paper kymograph. In 1939 he published photograh tracings made by low mass minature light bulbs attached to ataxic limbs that showed thehpometira and hypometria of their movements ipsilateral to their damaged cerebellar lobes. Holmes made sigficant contributions to understanding of the physiology of the human cerebellum. PMID:21480038

  19. Lateral boundary conditions for the Klein-Gordon-Fock equation

    NASA Astrophysics Data System (ADS)

    Tulenov, Kanat S.; Dauitbek, Dostilek

    2016-08-01

    In this paper we consider an initial-boundary value problem for the Klein-Gordon-Fock equation. We prove the uniqueness of the solution and find lateral boundary conditions for the Klein-Gordon-Fock equation.

  20. 1. VIEW OF MEDIAN FROM GORDON HIGHWAY OVERPASS, LOOKING WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW OF MEDIAN FROM GORDON HIGHWAY OVERPASS, LOOKING WEST SHOWING REVOLUTIONARY WAR MONUMENT 56/1 - Greene Street Historic District, Greene Street, Gordon Highway to Augusta Canal Bridge, Augusta, Richmond County, GA

  1. Role of AAA(+)-proteins in peroxisome biogenesis and function.

    PubMed

    Grimm, Immanuel; Erdmann, Ralf; Girzalsky, Wolfgang

    2016-05-01

    Mutations in the PEX1 gene, which encodes a protein required for peroxisome biogenesis, are the most common cause of the Zellweger spectrum diseases. The recognition that Pex1p shares a conserved ATP-binding domain with p97 and NSF led to the discovery of the extended family of AAA+-type ATPases. So far, four AAA+-type ATPases are related to peroxisome function. Pex6p functions together with Pex1p in peroxisome biogenesis, ATAD1/Msp1p plays a role in membrane protein targeting and a member of the Lon-family of proteases is associated with peroxisomal quality control. This review summarizes the current knowledge on the AAA+-proteins involved in peroxisome biogenesis and function.

  2. Distribution of Wall Stress in Abdominal Aortic Aneurysm (AAA)

    NASA Astrophysics Data System (ADS)

    Lasheras, Juan

    2005-11-01

    Abdominal aortic aneurysm (AAA) rupture is believed to occur when the mechanical stress acting on the wall exceeds the strength of the wall tissue. Therefore, knowledge of the AAA wall stress distribution could be useful in assessing its risk of rupture. In our research, a finite element analysis was used to determine the wall stresses both in idealized models and in a real clinical model in which the aorta was considered isotropic with nonlinear material properties and was loaded with a given pressure. In the idealized models, both maximum diameter and asymmetry were found to have substantial influence on the distribution of the wall stress. The thrombus inside the AAA was also found to help protecting the walls from high stresses. Using CT scans of the AAA, the actual geometry of the aneurysm was reconstructed and we found that wall tension increases on the flatter surface (typically corresponds to the posterior surface) and at the inflection points of the bulge. In addition to the static analysis, we also performed simulations of the effect of unsteady pressure wave propagation inside the aneurysm.

  3. Ex-congressman Rush Holt to lead AAAS

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2015-01-01

    The particle physicist Rush Holt, who served in the US Congress for 15 years, has been named as the next chief executive of the American Association for the Advancement of Science (AAAS) - the non-profit US society that promotes public engagement with science and technology.

  4. The Adult Asperger Assessment (AAA): A Diagnostic Method

    ERIC Educational Resources Information Center

    Baron-Cohen, Simon; Wheelwright, Sally; Robinson, Janine; Woodbury-Smith, Marc

    2005-01-01

    At the present time there are a large number of adults who have "suspected" Asperger syndrome (AS). In this paper we describe a new instrument, the Adult Asperger Assessment (AAA), developed in our clinic for adults with AS. The need for a new instrument relevant to the diagnosis of AS in adulthood arises because existing instruments are designed…

  5. THE AAA3 DOMAIN OF CYTOPLASMIC DYNEIN ACTS AS A SWITCH TO FACILITATE MICROTUBULE RELEASE

    PubMed Central

    Dewitt, Mark A.; Cypranowska, Caroline A.; Cleary, Frank B.; Belyy, Vladislav; Yildiz, Ahmet

    2014-01-01

    Cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation along microtubules (MTs). Unlike kinesin and myosin, dynein contains multiple ATPase subunits, with AAA1 serving as the primary catalytic site. ATPase activity at AAA3 is also essential for robust motility, but its role in dynein’s mechanochemical cycle remains unclear. Here, we introduced transient pauses in Saccharomyces cerevisiae dynein motility by using a slowly hydrolyzing ATP analog. Analysis of pausing behavior revealed that AAA3 hydrolyzes nucleotide an order of magnitude slower than AAA1 and the two sites do not coordinate. ATPase mutations to AAA3 abolish the ability of dynein to modulate MT release. Nucleotide hydrolysis at AAA3 lifts this “MT gate” to fast motility. These results suggest that AAA3 acts as a switch that repurposes cytoplasmic dynein for fast cargo transport and MT anchoring tasks in cells. PMID:25486306

  6. Astronaut Gordon Cooper in centrifuge for tests

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut L. Gordon Cooper, prime pilot for the Mercury-Atlas 9 mission, is strapped into the gondola while undergoing tests in the centrifuge at the Naval Air Development Center, Johnsville, Pennsylvania. The centrifuge is used to investigate by simulation the pilot's capability to control the vehicle during the actual flight in its booster and reentry profile.

  7. Astronaut Gordon Cooper smiles for recovery crew

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut L. Gordon Cooper Jr., has a smile for the recovery crew of the U.S.S. Kearsarge, after he is on board from a successful 22 orbit mission of the earth in his spacecraft 'Faith 7'. Cooper is still sitting in his capsule, with his helmet off.

  8. 1999 Gordon Research Conference on Atmospheric Chemistry

    SciTech Connect

    Storm, C.

    2000-08-01

    The Gordon Research Conference (GRC) on Atmospheric Chemistry was held at Salve Regina University in Newport, Rhode Island, June 13-18, 1999. The conference was well attended with 151 participants. The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both US and foreign scientists, senior researchers, young investigators, and students.

  9. The Religion Journalism of James Gordon Bennett.

    ERIC Educational Resources Information Center

    Buddenbaum, Judith M.

    A study was conducted to examine the journalism work of James Gordon Bennett, who founded the "New York Herald" in the 1830s, and to determine the nature of his coverage of religion before, during, and after the "Moral War" waged in 1840 against Bennett's popular newspaper. In addition, the study analyzed what Bennett's religion coverage reveals…

  10. Molecularly Defined Nanostructures Based on a Novel AAA-DDD Triple Hydrogen-Bonding Motif.

    PubMed

    Papmeyer, Marcus; Vuilleumier, Clément A; Pavan, Giovanni M; Zhurov, Konstantin O; Severin, Kay

    2016-01-26

    A facile and flexible method for the synthesis of a new AAA-DDD triple hydrogen-bonding motif is described. Polytopic supramolecular building blocks with precisely oriented AAA and DDD groups are thus accessible in few steps. These building blocks were used for the assembly of large macrocycles featuring four AAA-DDD interactions and a macrobicyclic complex with a total of six AAA-DDD interactions.

  11. Inhibition of early AAA formation by aortic intraluminal pentagalloyl glucose (PGG) infusion in a novel porcine AAA model

    PubMed Central

    Kloster, Brian O.; Lund, Lars; Lindholt, Jes S.

    2016-01-01

    Background The vast majority of abdominal aortic aneurysms found in screening programs are small, and as no effective treatment exits, many will expand until surgery is indicated. Therefore, it remains intriguing to develop a safe and low cost treatment of these small aneurysms, that is able to prevent or delay their expansion. In this study, we investigated whether intraluminal delivered pentagalloyl glucose (PGG) can impair the early AAA development in a porcine model. Methods The infrarenal aorta was exposed in thirty pigs. Twenty underwent an elastase based AAA inducing procedure and ten of these received an additional intraluminal PGG infusion. The final 10 were sham operated and served as controls. Results All pigs who only had an elastase infusion developed macroscopically expanding AAAs. In pigs treated with an additional PGG infusion the growth rate of the AP-diameter rapidly returned to physiological values as seen in the control group. In the elastase group, histology revealed more or less complete resolution of the elastic lamellae in the media while they were more abundant, coherent and structurally organized in the PGG group. The control group displayed normal physiological growth and histology. Conclusion In our model, intraluminal delivered PGG is able to penetrate the aortic wall from the inside and impair the early AAA development by stabilizing the elastic lamellae and preserving their integrity. The principle holds a high clinical potential if it can be translated to human conditions, since it, if so, potentially could represent a new drug for stabilizing small abdominal aneurysms. PMID:27144001

  12. U.S. Commission on Civil Rights' 40th Anniversary: The Road Ahead for Civil Rights. A Civil Rights Symposium.

    ERIC Educational Resources Information Center

    Civil Rights Journal, 1997

    1997-01-01

    This special theme issue of the newly titled "Civil Rights Journal" (previously titled "Perspectives"), commemorates the 40th anniversary of the U.S. Commission on Civil Rights by presenting a written symposium that offers a wide range of perspectives on civil rights realities and the future of civil rights. Three context-setting articles…

  13. Discourses of Inclusion and Exclusion in the Commemoration of the 40th Anniversary of the Portuguese Revolution

    ERIC Educational Resources Information Center

    de Oliveira, Sandi Michele

    2014-01-01

    This article takes a discourse analytical approach to elements of the 40th commemoration of the Portuguese Revolution, focusing specifically on the absence of themes and participants by groups who were most directly involved in the Revolution, either as actors (the "Captains of Abril"), the "retornados" (Portuguese nationals…

  14. Transgenic proteins in agricultural biotechnology: The toxicology forum 40th annual summer meeting.

    PubMed

    Sherman, James H; Choudhuri, Supratim; Vicini, John L

    2015-12-01

    During the 40th Annual Meeting of The Toxicology Forum, the current and potential future science, regulations, and politics of agricultural biotechnology were presented and discussed. The range of current commercial crops and commercial crop traits related to transgenic proteins were reviewed and example crop traits discussed, including insecticidal resistance conferred by Bt proteins and the development of nutritionally enhanced food such as Golden Rice. The existing regulatory framework in the USA, with an emphasis on US FDA's role in evaluating the safety of genetically engineered crops under the regulatory umbrella of the FD&C Act was reviewed. Consideration was given to the polarized politics surrounding agricultural biotechnology, the rise of open access journals, and the influence of the internet and social media in shaping public opinion. Numerous questions related to misconceptions regarding current products and regulations were discussed, highlighting the need for more scientists to take an active role in public discourse to facilitate public acceptance and adoption of new technologies and to enable science-based regulations. PMID:26493003

  15. RNAi technologies in agricultural biotechnology: The Toxicology Forum 40th Annual Summer Meeting.

    PubMed

    Sherman, James H; Munyikwa, Tichafa; Chan, Stephen Y; Petrick, Jay S; Witwer, Kenneth W; Choudhuri, Supratim

    2015-11-01

    During the 40th Annual Meeting of The Toxicology Forum, the current and potential future science, regulations, and politics of agricultural biotechnology were presented and discussed. The meeting session described herein focused on the technology of RNA interference (RNAi) in agriculture. The general process by which RNAi works, currently registered RNAi-based plant traits, example RNAi-based traits in development, potential use of double stranded RNA (dsRNA) as topically applied pesticide active ingredients, research related to the safety of RNAi, biological barriers to ingested dsRNA, recent regulatory RNAi science reviews, and regulatory considerations related to the use of RNAi in agriculture were discussed. Participants generally agreed that the current regulatory framework is robust and appropriate for evaluating the safety of RNAi employed in agricultural biotechnology and were also supportive of the use of RNAi to develop improved crop traits. However, as with any emerging technology, the potential range of future products, potential future regulatory frameworks, and public acceptance of the technology will continue to evolve. As such, continuing dialogue was encouraged to promote education of consumers and science-based regulations. PMID:26361858

  16. Transgenic proteins in agricultural biotechnology: The toxicology forum 40th annual summer meeting.

    PubMed

    Sherman, James H; Choudhuri, Supratim; Vicini, John L

    2015-12-01

    During the 40th Annual Meeting of The Toxicology Forum, the current and potential future science, regulations, and politics of agricultural biotechnology were presented and discussed. The range of current commercial crops and commercial crop traits related to transgenic proteins were reviewed and example crop traits discussed, including insecticidal resistance conferred by Bt proteins and the development of nutritionally enhanced food such as Golden Rice. The existing regulatory framework in the USA, with an emphasis on US FDA's role in evaluating the safety of genetically engineered crops under the regulatory umbrella of the FD&C Act was reviewed. Consideration was given to the polarized politics surrounding agricultural biotechnology, the rise of open access journals, and the influence of the internet and social media in shaping public opinion. Numerous questions related to misconceptions regarding current products and regulations were discussed, highlighting the need for more scientists to take an active role in public discourse to facilitate public acceptance and adoption of new technologies and to enable science-based regulations.

  17. RNAi technologies in agricultural biotechnology: The Toxicology Forum 40th Annual Summer Meeting.

    PubMed

    Sherman, James H; Munyikwa, Tichafa; Chan, Stephen Y; Petrick, Jay S; Witwer, Kenneth W; Choudhuri, Supratim

    2015-11-01

    During the 40th Annual Meeting of The Toxicology Forum, the current and potential future science, regulations, and politics of agricultural biotechnology were presented and discussed. The meeting session described herein focused on the technology of RNA interference (RNAi) in agriculture. The general process by which RNAi works, currently registered RNAi-based plant traits, example RNAi-based traits in development, potential use of double stranded RNA (dsRNA) as topically applied pesticide active ingredients, research related to the safety of RNAi, biological barriers to ingested dsRNA, recent regulatory RNAi science reviews, and regulatory considerations related to the use of RNAi in agriculture were discussed. Participants generally agreed that the current regulatory framework is robust and appropriate for evaluating the safety of RNAi employed in agricultural biotechnology and were also supportive of the use of RNAi to develop improved crop traits. However, as with any emerging technology, the potential range of future products, potential future regulatory frameworks, and public acceptance of the technology will continue to evolve. As such, continuing dialogue was encouraged to promote education of consumers and science-based regulations.

  18. [The system of selection and training of military-medical staff for the 40th army (1979-1989)].

    PubMed

    Ryabinkin, V V

    2015-10-01

    In December 1979 in order to fulfil their internationalist duty troops and units of the 40th Army of the Armed Forces of the USSR was brought into Afghanistan. For complete and qualitative manning of the army with the military doctors it was needed in a short time to create a system capable to carry out candidates selection, their education and specialized training for work in extreme conditions of combat operations. This system was created in a short time. The article presents information about its features, advantages and problems that had to be solved during the entire period of the Soviet-Afghan war. The complex staff arrangements had allowed solving medical support problems of the 40th Army on the high level.

  19. 2011 Clusters, Nanocrystals & Nanostructures Gordon Research Conference

    SciTech Connect

    Lai-Sheng Wang

    2011-07-29

    Small particles have been at the heart of nanoscience since the birth of the field and now stand ready to make significant contributions to the big challenges of energy, health and sustainability. Atomic clusters show exquisite size-dependent electronic and magnetic properties and offer a new level of control in catalyses, sensors and biochips; functionalised nanocrystals offer remarkable optical properties and diverse applications in electronic devices, solar energy, and therapy. Both areas are complemented by a raft of recent advances in fabrication, characterization, and performance of a diversity of nanomaterials from the single atom level to nanowires, nanodevices, and biologically-inspired nanosystems. The goal of the 2011 Gordon Conference is thus to continue and enhance the interdisciplinary tradition of this series and discuss the most recent advances, fundamental scientific questions, and emerging applications of clusters, nanocrystals, and nanostructures. A single conference covering all aspects of nanoscience from fundamental issues to applications has the potential to create new ideas and stimulate cross fertilization. The meeting will therefore provide a balance among the three sub-components of the conference, true to its title, with a selection of new topics added to reflect rapid advances in the field. The open atmosphere of a Gordon conference, emphasizing the presentation of unpublished results and extensive discussions, is an ideal home for this rapidly developing field and will allow all participants to enjoy a valuable and stimulating experience. Historically, this Gordon conference has been oversubscribed, so we encourage all interested researchers from academia, industry, and government institutions to apply as early as possible. We also encourage all attendees to submit their latest results for presentation at the poster sessions. We anticipate that several posters will be selected for 'hot topic' oral presentations. Given the important

  20. 2012 BATTERIES GORDON RESEARCH CONFERENCE, MARCH 4-9, 2012

    SciTech Connect

    Stephen Harris

    2012-03-09

    The Gordon Research Conference on BATTERIES was held at Four Points Sheraton / Holiday Inn Express, Ventura, California, March 4-9, 2012. The Conference was well-attended with 176 participants. Gordon Research Conferences does not permit publication of meeting proceedings.

  1. MA-9 PILOT L. GORDON COOPER INSIDE HIS MERCURY SPACECRAFT

    NASA Technical Reports Server (NTRS)

    1963-01-01

    MA-9 PILOT L. GORDON COOPER INSIDE HIS MERCURY SPACECRAFT S-63-6129 P-07144, ARCHIVE-03810 MA-9 pilot, L. Gordon Cooper, inside his Mercury spacecraft runs through one of the numerous pre-flight checks surrounded by dials, switches, indicators and buttons representing the complciated engineering technology of the space age.

  2. Psychometric Testing of the Gordon Facial Muscle Weakness Assessment Tool

    ERIC Educational Resources Information Center

    Gordon, Shirley C.; Blum, Cynthia Ann; Parcells, Dax Andrew

    2010-01-01

    School nurses may be the first health professionals to assess the onset of facial paralysis/muscle weakness in school-age children. The purpose of this study was to test the psychometric properties of the Gordon Facial Muscle Weakness Assessment Tool (GFMWT) developed by Gordon. Data were collected in two phases. In Phase 1, 4 content experts…

  3. Klein-Gordon Equation in Hydrodynamical Form

    SciTech Connect

    Wong, Cheuk-Yin

    2010-01-01

    We follow and modify the Feshbach-Villars formalism by separating the Klein-Gordon equation into two coupled time-dependent Schroedinger equations for the particle and antiparticle wave functions with positive probability densities. We find that the equation of motion for the probability densities is in the form of relativistic hydrodynamics where various forces have their physical and classical counterparts. An additional element is the presence of the quantum stress tensor that depends on the derivatives of the amplitude of the wave function.

  4. Differential expression of TRAIL and its receptors relative to calcification in AAA

    SciTech Connect

    Liu, Xun . E-mail: mpscrs@bath.ac.uk; Winrow, Vivienne R.; Horrocks, Michael; Stevens, Cliff R.

    2007-06-22

    Abdominal aortic aneurysm (AAA) is commonly associated with atherosclerosis. Human AAA tissue displays cells undergoing all stages of apoptosis. Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in tumour cells but not in normal cells. It has death receptors and decoy receptors. An inhibitor of TRAIL, osteoprotegerin (OPG), is involved in osteogenesis and vascular calcification. We investigated TRAIL and its receptors in AAA compared within normal aorta (NA). Both qualitative and quantitative analyses of calcification in AAA walls were determined using Von Kossa staining and pre-operation computer tomography (CT) scans. There was a significant difference in calcification level at different locations in the AAA wall (p < 0.05). Apoptosis was confirmed in AAA by TUNEL assay. A significant difference in TRAIL and its receptor expression was observed between normal aortae and AAA (p < 0.05). Significant differences were also observed between tissues displaying different extents of calcification for TRAIL mRNA (p < 0.05) by RT-PCR examination and OPG protein (p < 0.01) by protein blotting examination. We propose that this pattern of expression of TRAIL and its receptors may contribute to AAA formation and calcification in the AAA wall.

  5. Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.

    PubMed

    Kirstein, Janine; Molière, Noël; Dougan, David A; Turgay, Kürşad

    2009-08-01

    Members of the AAA+ protein superfamily contribute to many diverse aspects of protein homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic machines in bacteria, AAA+ proteins play a crucial part not only in general protein quality control but also in the regulation of developmental programmes, through the controlled turnover of key proteins such as transcription factors. To manage these many, varied tasks, Hsp100/Clp and AAA+ proteases use specific adaptor proteins to enhance or expand the substrate recognition abilities of their cognate protease. Here, we review our current knowledge of the modulation of bacterial AAA+ proteases by these cellular arbitrators.

  6. Engineering fluorescent protein substrates for the AAA+ Lon protease.

    PubMed

    Wohlever, Matthew L; Nager, Andrew R; Baker, Tania A; Sauer, Robert T

    2013-04-01

    AAA+ proteases, such as Escherichia coli Lon, recognize protein substrates by binding to specific peptide degrons and then unfold and translocate the protein into an internal degradation chamber for proteolysis. For some AAA+ proteases, attaching specific degrons to the N- or C-terminus of green fluorescent protein (GFP) generates useful substrates, whose unfolding and degradation can be monitored by loss of fluorescence, but Lon fails to degrade appropriately tagged GFP variants at a significant rate. Here, we demonstrate that Lon catalyzes robust unfolding and degradation of circularly permuted variants of GFP with a β20 degron appended to the N terminus or a sul20 degron appended to the C terminus. Lon degradation of non-permuted GFP-sul20 is very slow, in part because the enzyme cannot efficiently extract the degron-proximal C-terminal β-strand to initiate denaturation. The circularly permuted GFP substrates described here allow convenient high-throughput assays of the kinetics of Lon degradation in vitro and also permit assays of Lon proteolysis in vivo.

  7. Training Scientists to be Effective Communicators: AAAS Communicating Science Workshops

    NASA Astrophysics Data System (ADS)

    Cendes, L.; Lohwater, T.

    2012-12-01

    "Communicating Science: Tools for Scientists and Engineers" is a workshop program developed by AAAS to provide guidance and practice for scientists and engineers in communicating about science with public audiences. The program was launched at the 2008 AAAS Annual Meeting in Boston and has since provided 24 workshops for more than 1,500 scientist and engineer attendees at universities, science society meetings, and government agency labs around the United States. Each interactive workshop targets scientists and engineers specifically and has included content such as message development, defining audience, identifying opportunities for engaging the public, and practice with public presentations and cameras. The workshop format allows for collaborative learning through small-group discussion, resource sharing, and participation in critique of other participants' presentations. Continuous monitoring of the program includes on-site and online surveys and evaluation. On an assessment of workshops from 2008-2010, attendees reported that knowledge gained from the workshop helped in crafting messages about their scientific work for use in communicating with public audiences, and approximately 80 percent of respondents reported participation in communication with a public audience after attending the workshop. Through workshop content and feedback of participating scientists, this presentation will highlight some best practices and resources for scientists who want to take a proactive role in science communication.

  8. The Dynamical Sine-Gordon Model

    NASA Astrophysics Data System (ADS)

    Hairer, Martin; Shen, Hao

    2016-02-01

    We introduce the dynamical sine-Gordon equation in two space dimensions with parameter {β}, which is the natural dynamic associated to the usual quantum sine-Gordon model. It is shown that when {β2 in (0, 16π/3)} the Wick renormalised equation is well-posed. In the regime {β2 in (0, 4π)}, the Da Prato-Debussche method [J Funct Anal 196(1):180-210, 2002; Ann Probab 31(4):1900-1916, 2003] applies, while for {β2 in [4π, 16π/3)}, the solution theory is provided via the theory of regularity structures [Hairer, Invent Math 198(2):269-504, 2014]. We also show that this model arises naturally from a class of {2 + 1} -dimensional equilibrium interface fluctuation models with periodic nonlinearities. The main mathematical difficulty arises in the construction of the model for the associated regularity structure where the role of the noise is played by a non-Gaussian random distribution similar to the complex multiplicative Gaussian chaos recently analysed in Lacoin et al. [Commun Math Phys 337(2):569-632, 2015].

  9. 2012 ELECTRODEPOSITION GORDON RESEARCH CONFERENCE AND GORDON RESEARCH SEMINAR, JULY 29 - AUGUST 3, 2012

    SciTech Connect

    Gewirth, Andrew

    2013-08-03

    The 2012 Gordon Conference on Electrodeposition: Electrochemical Materials Synthesis and Applications will present cutting-edge research on electrodeposition with emphasis on (i) advances in basic science, (ii) developments in next-generation technologies, and (iii) new and emerging areas. The Conference will feature a wide range of topics, from atomic scale processes, nucleation and growth, thin film deposition, and electrocrystallization, to applications of electrodeposition in devices including microelectronics, batteries, solar energy, and fuel cells.

  10. The 2013 Clusters, Nanocrystals & Nanostructures Gordon Research Conference/Gordon Research Seminar

    SciTech Connect

    Krauss, Todd D.

    2014-11-25

    The fundamental properties of small particles and their potential for groundbreaking applications are among the most exciting areas of study in modern physics, chemistry, and materials science. The Clusters, Nanocrystals & Nanostructures Gordon ResearchConference and Gordon Research Seminar synthesize contributions from these inter-related fields that reflect the pivotal role of nano-particles at the interface between these disciplines. Size-dependent optical, electronic, magnetic and catalytic properties offer prospects for applications in many fields, and possible solutions for many of the grand challenges facing energy generation, consumption, delivery, and storage in the 21st century. The goal of the 2013 Clusters, Nanocrystals & Nanostructures Gordon Research Conference and Gordon Research Seminar is to continue the historical interdisciplinary tradition of this series and discuss the most recent advances, basic scientific questions, and emerging applications of clusters, nanocrystals, and nanostructures. The Clusters, Nanocrystals & Nanostructures GRC/GRS traditionally brings together the leading scientific groups that have made significant recent advances in one or more fundamental nanoscience or nanotechnology areas. Broad interests of the DOE BES and Solar Photochemistry Program addressed by this meeting include the areas of solar energy to fuels conversion, new photovoltaic systems, fundamental characterization of nanomaterials, magnetism, catalysis, and quantum physics. The vast majority of speakers and attendees will address either directly the topic of nanotechnology for photoinduced charge transfer, charge transport, and catalysis, or will have made significant contributions to related areas that will impact these fields indirectly. These topics have direct relevance to the mission of the DOE BES since it is this cutting-edge basic science that underpins our energy future.

  11. Analysis of a Typical Chinese High School Biology Textbook Using the AAAS Textbook Standards

    ERIC Educational Resources Information Center

    Liang, Ye; Cobern, William W.

    2013-01-01

    The purpose of this study was to evaluate a typical Chinese high school biology textbook using the textbook standards of the American Association for the Advancement of Science (AAAS). The data were composed of three chapters selected from the textbook. Each chapter was analyzed and rated using the AAAS textbook standards. Pearson correlations…

  12. [40th anniversary of the 736th Main Center of State Sanitary and Epidemiological Surveillance of the Russian Defense Ministry].

    PubMed

    Soloveĭ, È P; Berskiĭ, O V; Ian'shin, L A

    2012-11-01

    In November 2012 736th Main Center of State Sanitary and Epidemiological Supervision of the Ministry of Defense of the Russian Federation celebrates 40th anniversary. It is a multidisciplanary prevention and treatment facility of high level standing at the top of the sanitary-epidemiological institutions of the army and navy. The Main Center is included into a united, centralized system of state sanitary-epidemiological control of Russia with the main purpose--organization and conduction of surveillance and anti-epidemic (preventive) measures in the army and navy. The article provides a consistent presentation of historical perspective of creation and development of the institution and its mission today. PMID:23301297

  13. Perturbative Solutions of the Einstein Klein-Gordon Equations

    NASA Astrophysics Data System (ADS)

    Puliti, Gianluca; Jennings, Mara; Mamo, Vincent; Vuille, Chris

    2005-11-01

    As the Klein-Gordon equation is important in quantum theory and describes spin-0 particles, it is of interest to discover the nature of the gravity field such particles would be expected to create. In this paper, we solve the static, massive Einstein-Klein-Gordon (EKG) equations in perturbation, and compare the results with a similar calculation developed for the Einstein-Proca system. Subsequently, we study the massless static Klein-Gordon equation, and compare the result to the Reissner-Nordstrom metric.

  14. 2011 GASEOUS IONS GORDON RESEARCH CONFERENCE

    SciTech Connect

    Scott Anderson

    2011-03-04

    The Gaseous Ions: Structures, Energetics and Reactions Gordon Research Conference will focus on ions and their interactions with molecules, surfaces, electrons, and light. The conference will cover theory and experiments, and systems ranging from molecular to biological to clusters to materials. The meeting goal continues to be bringing together scientists interested in fundamentals, with those applying fundamental phenomena to a wide range of practical problems. Each of the ten conference sessions will focus on a topic within this spectrum, and there will also be poster sessions for contributed papers, with sufficient space and time to allow all participants to present their latest results. To encourage active participation by young investigators, about ten of the poster abstracts will be selected for 15 minute 'hot topic' talks during the conference sessions. Hot topic selection will be done about a month before the meeting. Funds should be available to offset the participation cost for young investigators.

  15. Gordon Research Conference on Mammary Gland Biology

    SciTech Connect

    Not Available

    1989-01-01

    The 1989 conference was the tenth in the series of biennial Gordon Research Conferences on Mammary Gland Biology. Traditionally this conference brings together scientists from diverse backgrounds and experience but with a common interest in the biology of the mammary gland. Investigators from agricultural and medical schools, biochemists, cell and molecular biologists, endocrinologists, immunologists, and representatives from the emerging biotechnology industries met to discuss current concepts and results on the function and regulation of the normal and neoplastic mammary gland in a variety of species. Of the participants, approximately three-fourths were engaged in studying the normal mammary gland function, whereas the other quarter were engaged in studying the neoplastic gland. The interactions between scientists, clinicians, veterinarians examining both normal and neoplastic cell function serves to foster the multi-disciplinary goals of the conference and has stimulated many cooperative projects among participants in previous years.

  16. Gordon Fullerton in PCA (MD-11) Simulator

    NASA Technical Reports Server (NTRS)

    1998-01-01

    NASA research pilot Gordon Fullerton 'flying' in the MD-11 simulator during the Propulsion Controlled Aircraft (PCA) project. This investigation grew out of the crash of a DC-10 airliner on July 19, 1989, following an explosion in the rear engine which caused the loss of all manual flight controls. The flight crew attempted to control the airliner using only the thrust from the two remaining engines. Although the DC-10 crashed during the landing attempt, 184 of the 296 passengers and crew aboard survived. The PCA effort at the Dryden Flight Research Center grew out of the crash, and attempted to develop a means to successfully land an aircraft using only engine thrust. After more than five years of work, on August 29, 1995, Gordon Fullerton made the first PCA touchdown aboard an MD-11 airliner (a later version of the DC-10). The concept was further refined over the years that followed this first landing. Simulators were essential ingredients of the PCA development process. The feasibility of the concept was first tested with an F-15 simulator, then the results of actual flight tests in an F-15 were incorporated back into the simulator. Additional simulations were run on the Boeing 720 airliner simulator used in the Controlled Impact Demonstration project. After the MD-11 test landings, Boeing 747 and 757 simulators tested a wide range of possible situations. Simulations even helped develop a method of landing an airliner if it lost its complete hydraulic system as well as a wing engine, by transferring fuel to shift the center of gravity toward the working engine. The most extreme procedure was undertaken in a 747 simulator. The aircraft simulated the loss of the hydraulic system at 35,000 feet and rolled upside down. Then, the PCA mode was engaged, the airliner righted itself, leveled its wings, and made an approach nearly identical to that of a normal auto landing.

  17. Simulations to demonstrate reduction of the Gordon-Haus effect.

    PubMed

    Marcuse, D

    1992-01-01

    The superposition of spontaneous emission noise on a train of soliton pulses produces a random change of the center frequency of the soliton spectrum that causes a change of the group velocity of individual solitons, which in long-light-wave systems translates into a random jitter of the position of the pulses at the receiver. This phenomenon is known as the Gordon-Haus effect. If uncontrolled, the Gordon-Haus effect sets a definite limit on the permissible data rate or on the length of soliton-based light-wave systems. Recently Kodama and Hasegawa [Opt. Lett. 17, 31 (1992)] have shown that the Gordon-Haus effect can be suppressed by placing filters along the fiber that reduce the frequency jitter and the concomitant group-velocity changes. We demonstrate the reduction of the Gordon-Haus effect by computer simulations.

  18. Tropical Storm Gordon Makes a U-Turn

    NASA Video Gallery

    An animation of satellite observations from August 14-17, 2012, shows the birth and strengthening of the Atlantic Ocean's Tropical Storm Gordon making a U-turn and heading back to the east. This vi...

  19. Astronauts L. Gordon Cooper Jr. hoisted up to Navy helicopter

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Astronaut L. Gordon Cooper Jr. is hoisted up to a Navy helicopter during recovery operations in the Atlantic Ocean of the Gemini 5 spacecraft. The NASA Headquarter alternative photo number is 65-H-688.

  20. Astronaut L. Gordon Cooper Jr. during water egress training

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Astronaut L. Gordon Cooper Jr., Gemini 5 command pilot, sits in the Gemini Static Article 5 spacecraft and prepares to be lowered from the deck of the NASA Motor Vessel Retriever for water egress training in the Gulf.

  1. Astronaut Richard Gordon returns to hatch of spacecraft following EVA

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Astronaut Richard F. Gordon Jr., pilot for the Gemini 11 space flight, returns to the hatch of the spacecraft following extravehicular activity (EVA). This picture was taken over the Atlantic Ocean at approximately 160 nautical miles above the earth's surface.

  2. Astronaut Gordon Cooper walks to elevator to spacecraft 'Faith 7'

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut L. Gordon Cooper Jr. waited inside the transfer van for several minutes and then leaving the transfer van walked to the elevator which took him to the spacecraft 'Faith 7' atop the Atlas vehicle for his mission.

  3. Applied and Environmental Microbiology Gordon Research Conference

    SciTech Connect

    Wall, Judy D.

    2003-11-19

    The main objective of the Gordon Research Conference on Applied and Environmental Microbiology was to present and discuss new, fundamental research findings on microorganisms, their activities in the environment, their ecosystem-level effects, and their environmental or commercial applications. To accomplish this goal, knowledge of microbial diversity, interactions and population dynamics was required. The genomic basis of microbial processes, the cycling of naturally occurring and hazardous substances, and methodologies to assess the functional relationships of microorganisms in their habitats were essential for understanding the ecological consequences of microbial activities and the formulation of generalizing principles. In the last decade, molecular technology has revealed that microbial diversity is far more extensive than the limited view obtained from culturing procedures. Great advances in environmental microbiology have resulted from the development and application of molecular approaches to ecology and molecular evolution. A further surprise resulting from the application of these new tools is the blurring of the distinction between pathogenic traits versus those considered non-pathogenic. This year's conference addressed the issues of biodiversity, its development, and the impact of stress on gene selection and expression. In addition microbial metabolic versatility with toxins such as heavy metals, antibiotics, and organic pollutants were discussed. The nine session topics were (1) biodiversity and the bacterial species, (2) mechanisms of biodiversification, (3) biofilms in health and environment, (4) a genomic view of microbial response to stress, (5) microbial use of toxic metals, (6) microbial mineral formation and dissolution, (7) power and limitations of antimicrobials, (8) biodegradation of organic pollutants, and (9) astrobiology. The Conference had an international profile: the Conference Vice-Chair, Dr. Gerard Muyzer, was from The Nether lands

  4. Gordon Research Conference on Genetic Toxicology

    SciTech Connect

    Project Director Penelope Jeggo

    2003-02-15

    Genetic toxicology represents a study of the genetic damage that a cell can incur, the agents that induce such damage, the damage response mechanisms available to cells and organisms, and the potential consequences of such damage. Genotoxic agents are abundant in the environment and are also induced endogenously. The consequences of such damage can include carcinogenesis and teratogenesis. An understanding of genetic toxicology is essential to carry out risk evaluations of the impact of genotoxic agents and to assess how individual genetic differences influence the response to genotoxic damage. In recent years, the importance of maintaining genomic stability has become increasingly recognized, in part by the realization that failure of the damage response mechanisms underlies many, if not all, cancer incidence. The importance of these mechanisms is also underscored by their remarkable conservation between species, allowing the study of simple organisms to provide significant input into our understanding of the underlying mechanisms. It has also become clear that the damage response mechanisms interface closely with other aspects of cellular metabolism including replication, transcription and cell cycle regulation. Moreover, defects in many of these mechanisms, as observed for example in ataxia telangiectasia patients, confer disorders with associated developmental abnormalities demonstrating their essential roles during growth and development. In short, while a decade ago, a study of the impact of DNA damage was seen as a compartmentalized area of cellular research, it is now appreciated to lie at the centre of an array of cellular responses of crucial importance to human health. Consequently, this has become a dynamic and rapidly advancing area of research. The Genetic Toxicology Gordon Research Conference is biannual with an evolving change in the emphasis of the meetings. From evaluating the nature of genotoxic chemicals, which lay at the centre of the early

  5. Modelling of residually stressed materials with application to AAA.

    PubMed

    Ahamed, T; Dorfmann, L; Ogden, R W

    2016-08-01

    Residual stresses are generated in living tissues by processes of growth and adaptation and they significantly influence the mechanical behaviour of the tissues. Thus, to effectively model the elastic response of the tissues relative to a residually stressed configuration the residual stresses need to be incorporated into the constitutive equations. The purposes of this paper are (a) to summarise a general elastic constitutive formulation that includes residual stress, (b) to specify the tensors needed for the three-dimensional implementation of the theory in a nonlinear finite element code, and (c) to use the theory and its implementation to evaluate the wall stress distribution in an abdominal aortic aneurysm (AAA) using patient specific geometry and material model parameters. The considered material is anisotropic with two preferred directions indicating the orientation of the collagen fibres in the aortic tissue. The method described in this paper is general and can be used, by specifying appropriate energy functions, to investigate other residually stressed biological systems. PMID:26874252

  6. 2010 Atomic & Molecular Interactions Gordon Research Conference

    SciTech Connect

    Todd Martinez

    2010-07-23

    The Atomic and Molecular Interactions Gordon Conferences is justifiably recognized for its broad scope, touching on areas ranging from fundamental gas phase and gas-condensed matter collision dynamics, to laser-molecule interactions, photophysics, and unimolecular decay processes. The meeting has traditionally involved scientists engaged in fundamental research in gas and condensed phases and those who apply these concepts to systems of practical chemical and physical interest. A key tradition in this meeting is the strong mixing of theory and experiment throughout. The program for 2010 conference continues these traditions. At the 2010 AMI GRC, there will be talks in 5 broadly defined and partially overlapping areas of intermolecular interactions and chemical dynamics: (1) Photoionization and Photoelectron Dynamics; (2) Quantum Control and Molecules in Strong Fields; (3) Photochemical Dynamics; (4) Complex Molecules and Condensed Phases; and (5) Clusters and Reaction Dynamics. These areas encompass many of the most productive and exciting areas of chemical physics, including both reactive and nonreactive processes, intermolecular and intramolecular energy transfer, and photodissociation and unimolecular processes. Gas phase dynamics, van der Waals and cluster studies, laser-matter interactions and multiple potential energy surface phenomena will all be discussed.

  7. 2010 Membranes: Materials & Processes Gordon Research Conference

    SciTech Connect

    Jerry Lin

    2010-07-30

    The GRC series on Membranes: Materials and Processes have gained significant international recognition, attracting leading experts on membranes and other related areas from around the world. It is now known for being an interdisciplinary and synergistic meeting. The next summer's edition will keep with the past tradition and include new, exciting aspects of material science, chemistry, chemical engineering, computer simulation with participants from academia, industry and national laboratories. This edition will focus on cutting edge topics of membranes for addressing several grand challenges facing our society, in particular, energy, water, health and more generally sustainability. During the technical program, we want to discuss new membrane structure and characterization techniques, the role of advanced membranes and membrane-based processes in sustainability/environment (including carbon dioxide capture), membranes in water processes, and membranes for biological and life support applications. As usual, the informal nature of the meeting, excellent quality of the oral presentations and posters, and ample opportunity to meet many outstanding colleagues make this an excellent conference for established scientists as well as for students. A Gordon Research Seminar (GRS) on the weekend prior to the GRC meeting will provide young researchers an opportunity to present their work and network with outstanding experts. It will also be a right warm-up for the conference participants to join and enjoy the main conference.

  8. Obituary: William Gordon (1918-2010)

    NASA Astrophysics Data System (ADS)

    Terzian, Yervant

    2011-12-01

    Bill Gordon was born in Paterson, New Jersey on January 8, 1918, and died in Ithaca, New York, on February 16, 2010. He is known as the engineer and ionospheric physicist who conceived and built the Arecibo giant radar/radio telescope. Bill graduated from Montclair State College in New Jersey and then in 1953 received his doctorate degree from Cornell University in electrical engineering, working under Henry Booker. During World War II he was in the Army where he studied the atmospheric conditions that affected radar transmissions. In the mid 1950s he began investigating giant antennas capable of studying the earths ionosphere. He succeeded in raising funds from the US Defense Department to construct the 1000 ft in diameter radar/radio telescope near the city of Arecibo on the island of Puerto Rico. The telescope was completed in 1963 under Bill's management, and he was its first Director. The huge fixed spherical antenna surface was made of a thin wire mesh allowing it to operate at frequencies up to about 600 MHz (50 cm wavelength). The spherical surface required complex 'line feeds' to correct for the spherical aberration, but allowed the telescope to track celestial radio sources by moving the line feeds which were supported by a platform suspended 500 ft above the reflector surface. Its sky coverage declination range was from -2 to +38 degrees. The large collecting area of the telescope made possible the detailed study of the physical properties of the earth's ionosphere. Measurements also included the rotation rates of the planets Mercury and Venus, radar imaging of the Moon and terrestrial planets. This new magastructure operated at low frequencies with its prime frequency at 430 MHz. One of Bill's passions was to make controlled experiments with the ionosphere. These so called 'heating experiments,' used a powerful HF radar transmitting from 5 to 10 MHz, to heat the ionosphere near the plasma frequency. The Arecibo radar then would study the heated

  9. Obituary: William Gordon (1918-2010)

    NASA Astrophysics Data System (ADS)

    Terzian, Yervant

    2011-12-01

    Bill Gordon was born in Paterson, New Jersey on January 8, 1918, and died in Ithaca, New York, on February 16, 2010. He is known as the engineer and ionospheric physicist who conceived and built the Arecibo giant radar/radio telescope. Bill graduated from Montclair State College in New Jersey and then in 1953 received his doctorate degree from Cornell University in electrical engineering, working under Henry Booker. During World War II he was in the Army where he studied the atmospheric conditions that affected radar transmissions. In the mid 1950s he began investigating giant antennas capable of studying the earths ionosphere. He succeeded in raising funds from the US Defense Department to construct the 1000 ft in diameter radar/radio telescope near the city of Arecibo on the island of Puerto Rico. The telescope was completed in 1963 under Bill's management, and he was its first Director. The huge fixed spherical antenna surface was made of a thin wire mesh allowing it to operate at frequencies up to about 600 MHz (50 cm wavelength). The spherical surface required complex 'line feeds' to correct for the spherical aberration, but allowed the telescope to track celestial radio sources by moving the line feeds which were supported by a platform suspended 500 ft above the reflector surface. Its sky coverage declination range was from -2 to +38 degrees. The large collecting area of the telescope made possible the detailed study of the physical properties of the earth's ionosphere. Measurements also included the rotation rates of the planets Mercury and Venus, radar imaging of the Moon and terrestrial planets. This new magastructure operated at low frequencies with its prime frequency at 430 MHz. One of Bill's passions was to make controlled experiments with the ionosphere. These so called 'heating experiments,' used a powerful HF radar transmitting from 5 to 10 MHz, to heat the ionosphere near the plasma frequency. The Arecibo radar then would study the heated

  10. AAA: Road Debris a Mounting Danger on U.S. Highways

    MedlinePlus

    ... Highways Crashes involving objects that have fallen from vehicles up 40 percent since 2001 To use the ... the AAA Foundation for Traffic Safety. Crashes involving vehicle-related debris are up 40 percent since the ...

  11. An AAA-DDD triply hydrogen-bonded complex easily accessible for supramolecular polymers.

    PubMed

    Han, Yi-Fei; Chen, Wen-Qiang; Wang, Hong-Bo; Yuan, Ying-Xue; Wu, Na-Na; Song, Xiang-Zhi; Yang, Lan

    2014-12-15

    For a complementary hydrogen-bonded complex, when every hydrogen-bond acceptor is on one side and every hydrogen-bond donor is on the other, all secondary interactions are attractive and the complex is highly stable. AAA-DDD (A=acceptor, D=donor) is considered to be the most stable among triply hydrogen-bonded sequences. The easily synthesized and further derivatized AAA-DDD system is very desirable for hydrogen-bonded functional materials. In this case, AAA and DDD, starting from 4-methoxybenzaldehyde, were synthesized with the Hantzsch pyridine synthesis and Friedländer annulation reaction. The association constant determined by fluorescence titration in chloroform at room temperature is 2.09×10(7)  M(-1) . The AAA and DDD components are not coplanar, but form a V shape in the solid state. Supramolecular polymers based on AAA-DDD triply hydrogen bonded have also been developed. This work may make AAA-DDD triply hydrogen-bonded sequences easily accessible for stimuli-responsive materials.

  12. Determining the influence of calcification on the failure properties of abdominal aortic aneurysm (AAA) tissue.

    PubMed

    O'Leary, Siobhan A; Mulvihill, John J; Barrett, Hilary E; Kavanagh, Eamon G; Walsh, Michael T; McGloughlin, Tim M; Doyle, Barry J

    2015-02-01

    Varying degrees of calcification are present in most abdominal aortic aneurysms (AAAs). However, their impact on AAA failure properties and AAA rupture risk is unclear. The aim of this work is evaluate and compare the failure properties of partially calcified and predominantly fibrous AAA tissue and investigate the potential reasons for failure. Uniaxial mechanical testing was performed on AAA samples harvested from 31 patients undergoing open surgical repair. Individual tensile samples were divided into two groups: fibrous (n=31) and partially calcified (n=38). The presence of calcification was confirmed by fourier transform infrared spectroscopy (FTIR). A total of 69 mechanical tests were performed and the failure stretch (λf), failure stress (σf) and failure tension (Tf) were recorded for each test. Following mechanical testing, the failure sites of a subset of both tissue types were examined using scanning electron microscopy (SEM)/energy dispersive X-ray spectroscopy (EDS) to investigate the potential reasons for failure. It has been shown that the failure properties of partially calcified tissue are significantly reduced compared to fibrous tissue and SEM and EDS results suggest that the junction between a calcification deposit and the fibrous matrix is highly susceptible to failure. This study implicates the presence of calcification as a key player in AAA rupture risk and provides further motivation for the development of non-invasive methods of measuring calcification.

  13. Determining the influence of calcification on the failure properties of abdominal aortic aneurysm (AAA) tissue.

    PubMed

    O'Leary, Siobhan A; Mulvihill, John J; Barrett, Hilary E; Kavanagh, Eamon G; Walsh, Michael T; McGloughlin, Tim M; Doyle, Barry J

    2015-02-01

    Varying degrees of calcification are present in most abdominal aortic aneurysms (AAAs). However, their impact on AAA failure properties and AAA rupture risk is unclear. The aim of this work is evaluate and compare the failure properties of partially calcified and predominantly fibrous AAA tissue and investigate the potential reasons for failure. Uniaxial mechanical testing was performed on AAA samples harvested from 31 patients undergoing open surgical repair. Individual tensile samples were divided into two groups: fibrous (n=31) and partially calcified (n=38). The presence of calcification was confirmed by fourier transform infrared spectroscopy (FTIR). A total of 69 mechanical tests were performed and the failure stretch (λf), failure stress (σf) and failure tension (Tf) were recorded for each test. Following mechanical testing, the failure sites of a subset of both tissue types were examined using scanning electron microscopy (SEM)/energy dispersive X-ray spectroscopy (EDS) to investigate the potential reasons for failure. It has been shown that the failure properties of partially calcified tissue are significantly reduced compared to fibrous tissue and SEM and EDS results suggest that the junction between a calcification deposit and the fibrous matrix is highly susceptible to failure. This study implicates the presence of calcification as a key player in AAA rupture risk and provides further motivation for the development of non-invasive methods of measuring calcification. PMID:25482218

  14. Klein-Gordon oscillator in Kaluza-Klein theory

    NASA Astrophysics Data System (ADS)

    Carvalho, Josevi; Carvalho, Alexandre M. de M.; Cavalcante, Everton; Furtado, Claudio

    2016-07-01

    In this contribution we study the Klein-Gordon oscillator on the curved background within the Kaluza-Klein theory. The problem of the interaction between particles coupled harmonically with topological defects in Kaluza-Klein theory is studied. We consider a series of topological defects, then we treat the Klein-Gordon oscillator coupled to this background, and we find the energy levels and corresponding eigenfunctions in these cases. We show that the energy levels depend on the global parameters characterizing these spacetimes. We also investigate a quantum particle described by the Klein-Gordon oscillator interacting with a cosmic dislocation in Som-Raychaudhuri spacetime in the presence of homogeneous magnetic field in a Kaluza-Klein theory. In this case, the energy spectrum is determined, and we observe that these energy levels represent themselves as the sum of the terms related with Aharonov-Bohm flux and of the parameter associated to the rotation of the spacetime.

  15. Verification of IMRT dose calculations using AAA and PBC algorithms in dose buildup regions.

    PubMed

    Oinam, Arun S; Singh, Lakhwant

    2010-08-26

    The purpose of this comparative study was to test the accuracy of anisotropic analytical algorithm (AAA) and pencil beam convolution (PBC) algorithms of Eclipse treatment planning system (TPS) for dose calculations in the low- and high-dose buildup regions. AAA and PBC algorithms were used to create two intensity-modulated radiotherapy (IMRT) plans of the same optimal fluence generated from a clinically simulated oropharynx case in an in-house fabricated head and neck phantom. The TPS computed buildup doses were compared with the corresponding measured doses in the phantom using thermoluminescence dosimeters (TLD 100). Analysis of dose distribution calculated using PBC and AAA shows an increase in gamma value in the dose buildup region indicating large dose deviation. For the surface areas of 1, 50 and 100 cm2, PBC overestimates doses as compared to AAA calculated value in the range of 1.34%-3.62% at 0.6 cm depth, 1.74%-2.96% at 0.4 cm depth, and 1.96%-4.06% at 0.2 cm depth, respectively. In high-dose buildup region, AAA calculated doses were lower by an average of -7.56% (SD = 4.73%), while PBC was overestimated by 3.75% (SD = 5.70%) as compared to TLD measured doses at 0.2 cm depth. However, at 0.4 and 0.6 cm depth, PBC overestimated TLD measured doses by 5.84% (SD = 4.38%) and 2.40% (SD = 4.63%), respectively, while AAA underestimated the TLD measured doses by -0.82% (SD = 4.24%) and -1.10% (SD = 4.14%) at the same respective depth. In low-dose buildup region, both AAA and PBC overestimated the TLD measured doses at all depths except -2.05% (SD = 10.21%) by AAA at 0.2 cm depth. The differences between AAA and PBC at all depths were statistically significant (p < 0.05) in high-dose buildup region, whereas it is not statistically significant in low-dose buildup region. In conclusion, AAA calculated the dose more accurately than PBC in clinically important high-dose buildup region at 0.4 cm and 0.6 cm depths. The use of an orfit cast increases the dose buildup

  16. 77 FR 51023 - R. Gordon Gooch v. Colonial Pipeline Company; Notice of Complaint

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-23

    ... Energy Regulatory Commission R. Gordon Gooch v. Colonial Pipeline Company; Notice of Complaint Take... 343.2 (2012)), R. Gordon Gooch (Complainant) filed a formal complaint against Colonial Pipeline.... R. Gordon Gooch states that a copy of the Complaint has been served on the contact for...

  17. Gemini 11 Commander Conrad and Pilot Gordon at post flight press conference

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Gemini 11 Commander Charles Conrad, Jr (left) and Pilot Richard F. Gordon, Jr describe mission activities during their post flight press conference at JSC. Gordon at the microphone talks about the extravehicular activity (EVA) photo projected behind the two crewmembers. During the EVA Gordon attached a tether to the Agena and retrieved a nuclear emulsion experiment package.

  18. Potpourri of comments about the fiber optic gyro for its 40th anniversary, and how fascinating it was and it still is!

    NASA Astrophysics Data System (ADS)

    Lefèvre, Hervé C.

    2016-05-01

    This 40th anniversary is the opportunity to recall how fascinating is the fiber-optic gyro with its potential perfection. Pure unaided strapdown inertial navigation yielding drift of less than one nautical mile in a month has been demonstrated in a laboratory. This paper also adds several comments about points that could be better known and should be outlined.

  19. Klein-Gordon and Dirac Equations with Thermodynamic Quantities

    NASA Astrophysics Data System (ADS)

    Arda, Altuğ; Tezcan, Cevdet; Sever, Ramazan

    2016-03-01

    We study the thermodynamic quantities such as the Helmholtz free energy, the mean energy and the specific heat for both the Klein-Gordon, and Dirac equations. Our analyze includes two main subsections: (1) statistical functions for the Klein-Gordon equation with a linear potential having Lorentz vector, and Lorentz scalar parts (2) thermodynamic functions for the Dirac equation with a Lorentz scalar, inverse-linear potential by assuming that the scalar potential field is strong ( A ≫ 1). We restrict ourselves to the case where only the positive part of the spectrum gives a contribution to the sum in partition function. We give the analytical results for high temperatures.

  20. 2007 Plant Metabolic Engineering Gordon Conference and Graduate Research Seminar

    SciTech Connect

    Erich Grotewold

    2008-09-15

    Plant Metabolic Engineering is an emerging field that integrates a diverse range of disciplines including plant genetics, genomics, biochemistry, chemistry and cell biology. The Gordon-Kenan Graduate Research Seminar (GRS) in Plant Metabolic Engineering was initiated to provide a unique opportunity for future researcher leaders to present their work in this field. It also creates an environment allowing for peer-review and critical assessment of work without the intimidation usually associated with the presence of senior investigators. The GRS immediately precedes the Plant Metabolic Engineering Gordon Research Conference and will be for and by graduate students and post-docs, with the assistance of the organizers listed.

  1. 2012 PLANT CELL WALLS GORDON RESEARCH CONFERENCE AND GORDON RESEARCH SEMINAR, AUGUST 4-10, 2012

    SciTech Connect

    Rose, Jocelyn

    2012-08-10

    The sub-theme of this year’s meeting, ‘Cell Wall Research in a Post-Genome World’, will be a consideration of the dramatic technological changes that have occurred in the three years since the previous cell wall Gordon Conference in the area of DNA sequencing. New technologies are providing additional perspectives of plant cell wall biology across a rapidly growing number of species, highlighting a myriad of architectures, compositions, and functions in both "conventional" and specialized cell walls. This meeting will focus on addressing the knowledge gaps and technical challenges raised by such diversity, as well as our need to understand the underlying processes for critical applications such as crop improvement and bioenergy resource development.

  2. 2010 PLASMONICS GORDON RESEARCH CONFERENCE/GORDON-KENAN GRADUATE STUDENT SEMINAR, JUNE 13-18

    SciTech Connect

    Naomi Halas

    2010-06-18

    The field of plasmonics lies at the forefront of current revolutionary developments in optics at nanoscale dimensions, with broad applications in the fields of biology, chemistry, and engineering. Advancing these applications will require an enhanced focus on the fundamental science of plasmonics in new and exotic regimes. This 2010 Gordon Conference on Plasmonics will focus on recent advances in fundamental and applied plasmonics. As with past conferences, this meeting will bring together top researchers and future leaders for substantial interactions between students, young speakers, and senior figures in the field. Participants should expect lively discussion during the sessions, intermingled with unstructured time where ideas move, collaborations form, and connections are made. Invited talks will cover a diverse range of topics, including active devices, coherence effects, metamaterials and cloaking, quantum optical phenomena, and plasmons in exotic media and in new wavelength regimes. At the conclusion of the conference, our final session will look forward and begin defining upcoming challenges and opportunities for plasmonics.

  3. 2012 ATOMIC AND MOLECULAR INTERACTIONS GORDON RESEARCH CONFERENCE AND GORDON RESEARCH SEMINAR, JULY 15-20, 2012

    SciTech Connect

    Zwier, Timothy

    2012-07-20

    At the 2012 Atomic and Molecular Interactions Gordon Conference, there will be talks in several broadly defined and partially overlapping areas:  Intramolecular and single-collision reaction dynamics;  Photophysics and photochemistry of excited states;  Clusters, aerosols and solvation;  Interactions at interfaces;  Conformations and folding of large molecules;  Interactions under extreme conditions of temperature and pressure. The theme of the Gordon Research Seminar on Atomic & Molecular Interactions, in keeping with the tradition of the Atomic and Molecular Interactions Gordon Research Conference, is far-reaching and involves fundamental research in the gas and condensed phases along with application of these ideas to practical chemical fields. The oral presentations, which will contain a combination of both experiment and theory, will focus on four broad categories:  Ultrafast Phenomena;  Excited States, Photoelectrons, and Photoions;  Chemical Reaction Dynamics;  Biomolecules and Clusters.

  4. Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains.

    PubMed

    Nicholas, Matthew P; Berger, Florian; Rao, Lu; Brenner, Sibylle; Cho, Carol; Gennerich, Arne

    2015-05-19

    Cytoplasmic dynein is a homodimeric microtubule (MT) motor protein responsible for most MT minus-end-directed motility. Dynein contains four AAA+ ATPases (AAA: ATPase associated with various cellular activities) per motor domain (AAA1-4). The main site of ATP hydrolysis, AAA1, is the only site considered by most dynein motility models. However, it remains unclear how ATPase activity and MT binding are coordinated within and between dynein's motor domains. Using optical tweezers, we characterize the MT-binding strength of recombinant dynein monomers as a function of mechanical tension and nucleotide state. Dynein responds anisotropically to tension, binding tighter to MTs when pulled toward the MT plus end. We provide evidence that this behavior results from an asymmetrical bond that acts as a slip bond under forward tension and a slip-ideal bond under backward tension. ATP weakens MT binding and reduces bond strength anisotropy, and unexpectedly, so does ADP. Using nucleotide binding and hydrolysis mutants, we show that, although ATP exerts its effects via binding AAA1, ADP effects are mediated by AAA3. Finally, we demonstrate "gating" of AAA1 function by AAA3. When tension is absent or applied via dynein's C terminus, ATP binding to AAA1 induces MT release only if AAA3 is in the posthydrolysis state. However, when tension is applied to the linker, ATP binding to AAA3 is sufficient to "open" the gate. These results elucidate the mechanisms of dynein-MT interactions, identify regulatory roles for AAA3, and help define the interplay between mechanical tension and nucleotide state in regulating dynein motility.

  5. Results of direct containment heating integral experiments at 1/40th scale at Argonne National Laboratory

    SciTech Connect

    Binder, J.L.; McUmber, L.M.; Spencer, B.W.

    1993-09-01

    A series of integral tests have been completed that investigate the effect of scale and containment atmosphere initial composition on Direct Containment Heating (DCH) phenomena at 1/40 linear scale. A portion of these experiments were performed as counterparts to integral experiments conducted at 1/10th linear scale at Sandia National Laboratories. The tests investigated DCH phenomena in a 1/40th scale mockup of Zion Nuclear Power Plant geometry. The test apparatus was a scaled down version of the SNL apparatus and included models of the reactor vessel lower head, containment cavity, instrument tunnel, lower subcompartment structures and the upper dome. A High Pressure Melt Ejection (HPME) was produced using steam as a blowdown gas and iron-alumina thermite with chromium as a core melt simulant. The results of the counterpart experiments indicated no effect of scale on debris/gas heat transfer and debris metal oxidation with steam. However, the tests indicated a slight effect of scale on hydrogen combustion, the results indicating slightly more efficient combustion with increasing scale. The experiments demonstrated the effectiveness of the subcompartment structures in trapping debris exiting the cavity and preventing it from reaching the upper dome. The test results also indicated that a 50% air -- 50% steam atmosphere prevented hydrogen combustion. However, a 50% air - 50% nitrogen did not prevent hydrogen combustion in a HPME with all other conditions being nominally the same.

  6. Identification of AAAS gene mutation in Allgrove syndrome: A report of three cases

    PubMed Central

    LI, WENJING; GONG, CHUNXIU; QI, ZHAN; WU, DI; CAO, BINGYAN

    2015-01-01

    Allgrove syndrome (AS) is an autosomal recessive congenital disease, caused by mutations in the AAAS gene, and is characterized by the triad of Addison's disease, achalasia and alacrima. The present study describes three newly diagnosed cases of AS, in which genetic analysis of the AAAS gene was used to identify AAAS gene mutations, to enhance the understanding of the pathogenesis and clinical manifestations of AS in the Chinese population. Two of the cases exhibited homozygous mutations of c.771delG (p.Arg258GlyfsX33) in exon 8 and one case exhibited a homozygous mutation of c.1366C>T (p.Q456X) in exon 15. A review of the current literature suggests that the AAAS c.771delG mutation has only been reported in the Chinese population. Genetic analysis of the AAAS gene in Chinese AS patients at a young age may facilitate an earlier diagnosis and the timely initiation of the appropriate treatment, ultimately improving the patient outcome. PMID:26622478

  7. 2011 Chemical Reactions at Surfaces Gordon Research Conference

    SciTech Connect

    Peter Stair

    2011-02-11

    The Gordon Research Conference on Chemical Reactions at Surfaces is dedicated to promoting and advancing the fundamental science of interfacial chemistry and physics by providing surface scientists with the foremost venue for presentation and discussion of research occurring at the frontiers of their fields.

  8. Becoming the University: Early Presidential Discourses of Gordon Gee

    ERIC Educational Resources Information Center

    Rishell, Michael W.

    2011-01-01

    The author explores Gordon Gee's career as a university president. There is a special focus on the journey Gee made between 1990, when he first became president of The Ohio State University, to 2007, when he returned to Ohio State for another term as university president ten years later. During this time away from Ohio State, he served as the…

  9. Generalized universality in the massive sine-Gordon model

    SciTech Connect

    Nagy, S.; Sailer, K.; Nandori, I.; Polonyi, J.

    2008-01-15

    A nontrivial interplay of the UV and IR scaling laws, a generalization of the universality is demonstrated in the framework of the massive sine-Gordon model, as a result of a detailed study of the global behavior of the renormalization group flow and the phase structure.

  10. Astronaut Gordon Cooper backs out of his spacecraft 'Faith 7'

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut L. Gordon Cooper backs out of his spacecraft 'Faith 7' after a 600,000 mile, 22.9 orbit journey around the earth. He elected to remain in the spacecraft until it was hoisted to the deck of the Kearsarge, as did Astronaut Walter Schirra during the previous mission.

  11. Astronauts Conrad and Gordon demonstrate tethering procedures for news media

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Astronauts Charles Conrad (left), command pilot, and Richard F. Gordon (right), pilot, demonstrate tether procedure between their Gemini 11 spacecraft and the Agena Target Docking Vehicle at the post flight press conference. They use models of their spacecraft and its Agena to illustrate maneuvers.

  12. Astronaut Gordon Cooper assisted into his Mercury Spacecraft

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut L. Gordon Cooper Jr., is assisted into his 'Faith 7' Mercury Spacecraft early Tuesday (May 14, 1963) morning. Cooper remained in the spacecraft for approximately 5 hours and then climbed out again as the mission was delayed because of trouble at a tracking station.

  13. Astronaut C. Gordon Fullerton in suit donning/doffing exercise

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Astronaut C. Gordon Fullerton, STS-3 pilot, takes part in a suit donning/doffing exercise aboard a KC-135 'zero-gravity' aircraft. Mission Specialist William F. Fisher, far left, holds a mirror to assist Fullerton with hose and cable linkups to his suit. Fullerton is wearing an extravehicular mobility unit (EMU) minus gloves and helmet.

  14. Astronaut Gordon Cooper assisted into his Mercury Spacecraft

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut L. Gordon Cooper Jr., pilot of the Mercury-Atlas 9 (MA-9) earth-orbital space mission, is assisted into his 'Faith 7' Mercury Spacecraft during the prelaunch countdown. MA-9 was launched on May 15, 1963, and the flight lasted for 34 hours and 20 minutes.

  15. Astronaut C. Gordon Fullerton in donning/doffing exercise experiences

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Astronaut C. Gordon Fullerton, STS-3 pilot, experiences free fall while taking part in a suit donning/doffing exercise aboard a KC-135 'zero-gravity' aircraft. Fullerton is wearing an extravehicular mobility unit (EMU) complete with gloves and helmet.

  16. Astronaut Gordon Cooper is assisted from his spacecraft 'Faith 7'

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut L. Gordon Cooper stands supported by strong hands after climbing out of his spacecraft 'Faith 7' after a 600,000 mile, 22.9 orbit journey around the earth. He elected to remain in the spacecraft until it was hoisted to the deck of the Kearsarge, as did Astronaut Walter Schirra during the previous mission.

  17. Astronaut Richard Gordon practices attaching camera to film EVA

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Astronaut Richard F. Gordon Jr., prime crew pilot for the Gemini 11 space flight, practices attaching to a Gemini boilerplate a camera which will film his extravehicular activity (EVA) outside the spacecraft. The training exercise is being conducted in the Astronaut Training Building, Kennedy Space Center, Florida.

  18. Control of antikinks of the Sine Gordon equation

    NASA Astrophysics Data System (ADS)

    Porubov, A. V.; Bondarenkov, R. S.; Fradkov, A. L.; Andrievsky, B. R.

    2016-06-01

    The control of the smoothness of an antikink profile of the Sine Gordon equation is considered. It is shown that variations in the initial conditions give rise to oscillations on the profile of the antikink. The control algorithm based on variation of one of the coefficient of the equation is developed to recover the smooth wave shape and the phase velocity of the antikink.

  19. Astronauts Conrad and Gordon demonstrate tethering procedures for news media

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Astronauts Charles Conrad (center), command pilot, and Richard F. Gordon (right), pilot, demonstrate tether procedure between their Gemini 11 spacecraft and the Agena Target Docking Vehicle at the post flight press conference. They use models of their spacecraft and its Agena to illustrate maneuvers. At left is George Low, Deputy Director, Manned Spacecraft Center, Houston.

  20. Exact solutions of the generalized Sinh-Gordon equation

    NASA Astrophysics Data System (ADS)

    Neirameh, A.

    2016-07-01

    In this paper, we successfully derive a new exact traveling wave solutions of the generalized Sinh-Gordon equation by new application of the homogeneous balance method. This method could be used in further works to establish more entirely new solutions for other kinds of nonlinear evolution equations arising in physics.

  1. Breather compactons in nonlinear Klein-Gordon systems.

    PubMed

    Dinda, P T; Remoissenet, M

    1999-11-01

    We demonstrate the existence of a localized breathing mode with a compact support, i.e., a stationary breather compacton, in a nonlinear Klein-Gordon system. This breather compacton results from a delicate balance between the harmonicity of the substrate potential and the total nonlinearity induced by the substrate potential and the coupling forces between adjacent lattice sites.

  2. Dynein motors: How AAA+ ring opening and closing coordinates microtubule binding and linker movement.

    PubMed

    Schmidt, Helgo

    2015-05-01

    Dyneins are a family of motor proteins that move along the microtubule. Motility is generated in the motor domain, which consists of a ring of six AAA+ (ATPases associated with diverse cellular activities) domains, the linker and the microtubule-binding domain (MTBD). The cyclic ATP-hydrolysis in the AAA+ ring causes the remodelling of the linker, which creates the necessary force for movement. The production of force has to be synchronized with cycles of microtubule detachment and rebinding to efficiently create movement along the microtubule. The analysis of four dynein motor domain crystal structures in the essay presented here provides evidence that this crucial coordination is carried out by open/closed AAA+ ring conformations.

  3. Cell-Activation by Shear Stresses in Abdominal Aortic Aneurysms (AAA)

    NASA Astrophysics Data System (ADS)

    Salsac, Anne-Virginie; Sparks, Steven; Chomaz, Jean-Marc; Lasheras, Juan C.

    2003-11-01

    Increasing experimental evidence indicates that low and oscillatory shear stresses promote proliferative, thrombotic, adhesive and inflammatory-mediated degenerative conditions throughout the wall of the aorta. These degenerative conditions have been shown to be involved in the pathogenesis of AAAs, a permanent, localized dilatation of the abdominal aorta. The purpose of this study is to measure both the magnitude and the duration of the shear stresses acting on both the arterial walls and on the blood cells inside AAAs, and to characterize their changes as the AAA enlarges. We conducted a parametric in-vitro study of the pulsatile blood flow in elastic models of AAAs while systematically varying the blood flow parameters, and the geometry of the aneurysm's bulging. The instantaneous flow characteristic inside the AAA was measured using DPIV at a sampling rate of 15 Hertz. A "cell-activation parameter" defined as the integral of the product of the magnitude of the shear stress and the time during which the stress acts was computed along each of the blood cell pathlines. The Lagrangian tracking of the blood cells shows that a large majority of them are subjected first to very high level of shear-induced "cell-activation" while later on they are entrained in regions of stasis where their residence time can increase up to several cardiac cycles. This cell-activation followed by the entrainment in low shear regions creates the optimal cell-adhesive and inflammatory-mediated degenerative conditions that are postulated to play an important role in the etiology and progressive enlargement of AAAs.

  4. 2012 MITOCHONDRIA AND CHLOROPLASTS GORDON RESEARCH CONFERENCE & GORDON RESEARCH SEMINAR, JULY 29 - AUGUST 3, 2012

    SciTech Connect

    Barkan, Alice

    2012-08-03

    The 2012 Gordon Research Conference on Mitochondria and Chloroplasts will assemble an international group of scientists investigating fundamental properties of these organelles, and their integration into broader physiological processes. The conference will emphasize the many commonalities between mitochondria and chloroplasts: their evolution from bacterial endosymbionts, their genomes and gene expression systems, their energy transducing membranes whose proteins derive from both nuclear and organellar genes, the challenge of maintaining organelle integrity in the presence of the reactive oxygen species that are generated during energy transduction, their incorporation into organismal signaling pathways, and more. The conference will bring together investigators working in animal, plant, fungal and protozoan systems who specialize in cell biology, genetics, biochemistry, physiology, proteomics, genomics, and structural biology. As such, this conference will provide a unique forum that engenders cross-disciplinary discussions concerning the biogenesis, dynamics, and regulation of these key cellular structures. By fostering interactions among mammalian, fungal and plant organellar biologists, this conference also provides a conduit for the transmission of mechanistic insights obtained in model organisms to applications in medicine and agriculture. The 2012 conference will highlight areas that are moving rapidly and emerging themes. These include new insights into the ultrastructure and organization of the energy transducing membranes, the coupling of organellar gene expression with the assembly of photosynthetic and respiratory complexes, the regulatory networks that couple organelle biogenesis with developmental and physiological signals, the signaling events through which organellar physiology influences nuclear gene expression, and the roles of organelles in disease and development.

  5. Localization of the sine-Gordon equation solutions

    NASA Astrophysics Data System (ADS)

    Porubov, A. V.; Fradkov, A. L.; Bondarenkov, R. S.; Andrievsky, B. R.

    2016-10-01

    Localization of the waves of the sine-Gordon equation depends on the shape of the initial condition. It is shown how initially motionless Gaussian distribution may be modified to obtain propagation of localized waves in both directions. However, the resulting localized wave profile is described neither by an asymptotic envelope- wave solution to the sine-Gordon equation nor by its exact traveling breather solution. The distributed control algorithms are developed to achieve wave localization independent of the shape of the initial condition. It is shown that localization of the waves in both directions is achieved by means of a feedforward (nonfeedback) control. The waves are similar to the envelope wave solution. The feedback distributed algorithm is shown to provide both localized waves according to analytical solutions and their unidirectional propagation.

  6. Radial sine-Gordon kinks as sources of fast breathers.

    PubMed

    Caputo, J-G; Soerensen, M P

    2013-08-01

    We consider radial sine-Gordon kinks in two, three, and higher dimensions. A full two-dimensional simulation showing that azimuthal perturbations remain small allows us to reduce the problem to the one-dimensional radial sine-Gordon equation. We solve this equation on an interval [r(0),r(1)] and absorb all outgoing radiation. As the kink shrinks toward r(0), before the collision, its motion is well described by a simple law derived from the conservation of energy. In two dimensions for r(0)≤2, the collision disintegrates the kink into a fast breather, while for r(0)≥4 we obtain a kink-breather metastable state where breathers are shed at each kink "return." In three and higher dimensions d, an additional kink-oscillon state appears for small r(0). On the application side, the kink disintegration opens the way for new types of terahertz microwave generators.

  7. Norwalk Community College AA-AS Degree Review Committee Curriculum Report, August 21, 1989.

    ERIC Educational Resources Information Center

    Pennino, Eileen M.; Luster, Gwen Tolliver

    In an attempt to revitalize and reform its curriculum, the Associate of Arts-Associate of Science (AA-AS) Degree Review Committee (DRC) of Connecticut's Norwalk Community College issued a curriculum report proposing a 21 credit, limited distributive core for the AS degree (which accounts for 80% of the college's degree recipients). This proposal…

  8. Professional Ethics Activities in the Scientific and Engineering Societies. AAAS Professional Ethics Project.

    ERIC Educational Resources Information Center

    Chalk, Rosemary; And Others

    Presented is an overview of the depth and range of the ethics activities undertaken by societies affiliated with the American Association for the Advancement of Science (AAAS). Included in this report are: (1) reviews of previous surveys of organizations which had adopted codes of ethics; (2) descriptions of the methodology and findings of the…

  9. Fluid Characteristics in Abdominal Aortic Aneurysms (AAAs) and Its Correlation to Thrombus Formation

    NASA Astrophysics Data System (ADS)

    Tang, Rubing; Bar-Yoseph, Pinhas Z.; Lasheras, Juan

    2008-11-01

    It has been observed that most large Abdominal Aortic Aneurysms (AAAs) develop an intraluminal thrombus as they progressively enlarge. Previous studies have suggested that the build up of the thrombus may be associated with the altered hemodynamic patterns that arise inside the AAA. We have performed a parametrical computational study of the flow patterns inside enlarging AAA to investigate the possible mechanism controlling the thrombus formation. Pulsatile blood flows were simulated in idealized models of fusiform aneurysms with different dilatation ratios and the effects of shear-activated platelet accumulation and platelet/wall interaction were evaluated based on the calculated flow fields. The platelet activation level (PAL) was determined by computing the integral over time of flow shear stresses exerted over the platelets as they are transported throughout the aneurysm. Our results have shown that the values of PAL in AAAs are in fact smaller than the maximum value obtained in a healthy abdominal aorta. However, we show that the transportation of blood cells towards the wall and the formation of stagnation points on the aneurysm's wall play more significant roles in thrombus formation than PAL.

  10. Effects of doping and bias voltage on the screening in AAA-stacked trilayer graphene

    NASA Astrophysics Data System (ADS)

    Mohammadi, Yawar; Moradian, Rostam; Shirzadi Tabar, Farzad

    2014-09-01

    We calculate the static polarization of AAA-stacked trilayer graphene (TLG) and study its screening properties within the random phase approximation (RPA) in all undoped, doped and biased regimes. We find that the static polarization of undoped AAA-stacked TLG is a combination of the doped and undoped single-layer graphene static polarization. This leads to an enhancement of the dielectric background constant along a Thomas-Fermi screening with the Thomas-Fermi wave vector which is independent of carrier concentrations and a 1/r3 power law decay for the long-distance behavior of the screened Coulomb potential. We show that effects of a bias voltage can be taken into account by a renormalization of the interlayer hopping energy to a new bias-voltage-dependent value, indicating screening properties of AAA-stacked TLG can be tuned electrically. We also find that screening properties of doped AAA-stacked TLG, when μ exceeds √{2}γ, are similar to that of doped SLG only depending on doping. While for μ<√{2}γ, its screening properties are combination of SLG and AA-stacked bilayer graphene screening properties and they are determined by doping and the interlayer hopping energy.

  11. Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major

    SciTech Connect

    Arakaki, Tracy; Le Trong, Isolde; Phizicky, Eric; Quartley, Erin; DeTitta, George; Luft, Joseph; Lauricella, Angela; Anderson, Lori; Kalyuzhniy, Oleksandr; Worthey, Elizabeth; Myler, Peter J.; Kim, David; Baker, David; Hol, Wim G. J.; Merritt, Ethan A.

    2006-03-01

    The crystal structure of a conserved hypothetical protein from L. major, Pfam sequence family PF04543, structural genomics target ID Lmaj006129AAA, has been determined at a resolution of 1.6 Å. The gene product of structural genomics target Lmaj006129 from Leishmania major codes for a 164-residue protein of unknown function. When SeMet expression of the full-length gene product failed, several truncation variants were created with the aid of Ginzu, a domain-prediction method. 11 truncations were selected for expression, purification and crystallization based upon secondary-structure elements and disorder. The structure of one of these variants, Lmaj006129AAH, was solved by multiple-wavelength anomalous diffraction (MAD) using ELVES, an automatic protein crystal structure-determination system. This model was then successfully used as a molecular-replacement probe for the parent full-length target, Lmaj006129AAA. The final structure of Lmaj006129AAA was refined to an R value of 0.185 (R{sub free} = 0.229) at 1.60 Å resolution. Structure and sequence comparisons based on Lmaj006129AAA suggest that proteins belonging to Pfam sequence families PF04543 and PF01878 may share a common ligand-binding motif.

  12. The two faces of hydrogen-bond strength on triple AAA-DDD arrays.

    PubMed

    Lopez, Alfredo Henrique Duarte; Caramori, Giovanni Finoto; Coimbra, Daniel Fernando; Parreira, Renato Luis Tame; da Silva, Éder Henrique

    2013-12-01

    Systems that are connected through multiple hydrogen bonds are the cornerstone of molecular recognition processes in biology, and they are increasingly being employed in supramolecular chemistry, specifically in molecular self-assembly processes. For this reason, the effects of different substituents (NO2, CN, F, Cl, Br, OCH3 and NH2) on the electronic structure, and consequently on the magnitude of hydrogen bonds in triple AAA-DDD arrays (A=acceptor, D=donor) were evaluated in the light of topological [electron localization function (ELF) and quantum theory of atoms in molecules (QTAIM)], energetic [Su-Li energy-decomposition analysis (EDA) and natural bond orbital analysis (NBO)], and geometrical analysis. The results based on local H-bond descriptors (geometries, QTAIM, ELF, and NBO) indicate that substitutions with electron-withdrawing groups on the AAA module tend to strengthen, whereas electron-donating substituents tend to weaken the covalent character of the AAA-DDD intermolecular H-bonds, and also indicate that the magnitude of the effect is dependent on the position of substitution. In contrast, Su-Li EDA results show an opposite behavior when compared to local H-bond descriptors, indicating that electron-donating substituents tend to increase the magnitude of H-bonds in AAA-DDD arrays, and thus suggesting that the use of local H-bond descriptors describes the nature of H bonds only partially, not providing enough insight about the strength of such H bonds.

  13. Anonymous Communication Policies for the Internet: Results and Recommendations of the AAAS Conference.

    ERIC Educational Resources Information Center

    Teich, Al; Frankel, Mark S.; Kling, Rob; Lee, Yaching

    1999-01-01

    Reports the results of a conference on the Internet and anonymous communication organized by the American Association for the Advancement of Science (AAAS). Discusses how anonymous communications can be shaped by the law, education, and public awareness, and highlights the importance of involving all affected interests in policy development.…

  14. The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development.

    PubMed

    Cox, G A; Mahaffey, C L; Nystuen, A; Letts, V A; Frankel, W N

    2000-10-01

    The mouse mutation fidget arose spontaneously in a heterogeneous albino stock. This mutant mouse is characterized by a side-to-side head-shaking and circling behaviour, due to reduced or absent semicircular canals. Fidget mice also have small eyes, associated with cell-cycle delay and insufficient growth of the retinal neural epithelium, and lower penetrance skeletal abnormalities, including pelvic girdle dysgenesis, skull bone fusions and polydactyly. By positional cloning, we found the gene mutated in fidget mice, fidgetin (Fign), which encodes a new member of the 'meiotic' or subfamily-7 (SF7; ref. 7) group of ATPases associated with diverse cellular activities (AAA proteins). We also discovered two closely related mammalian genes. AAA proteins are molecular chaperones that facilitate a variety of functions, including membrane fusion, proteolysis, peroxisome biogenesis, endosome sorting and meiotic spindle formation, but functions for the SF7 AAA proteins are largely unknown. Fidgetin is the first mutant AAA protein found in a mammalian developmental mutant, thus defining a new role for these proteins in embryonic development.

  15. National dosimetric audit network finds discrepancies in AAA lung inhomogeneity corrections.

    PubMed

    Dunn, Leon; Lehmann, Joerg; Lye, Jessica; Kenny, John; Kron, Tomas; Alves, Andrew; Cole, Andrew; Zifodya, Jackson; Williams, Ivan

    2015-07-01

    This work presents the Australian Clinical Dosimetry Service's (ACDS) findings of an investigation of systematic discrepancies between treatment planning system (TPS) calculated and measured audit doses. Specifically, a comparison between the Anisotropic Analytic Algorithm (AAA) and other common dose-calculation algorithms in regions downstream (≥2cm) from low-density material in anthropomorphic and slab phantom geometries is presented. Two measurement setups involving rectilinear slab-phantoms (ACDS Level II audit) and anthropomorphic geometries (ACDS Level III audit) were used in conjunction with ion chamber (planar 2D array and Farmer-type) measurements. Measured doses were compared to calculated doses for a variety of cases, with and without the presence of inhomogeneities and beam-modifiers in 71 audits. Results demonstrate a systematic AAA underdose with an average discrepancy of 2.9 ± 1.2% when the AAA algorithm is implemented in regions distal from lung-tissue interfaces, when lateral beams are used with anthropomorphic phantoms. This systemic discrepancy was found for all Level III audits of facilities using the AAA algorithm. This discrepancy is not seen when identical measurements are compared for other common dose-calculation algorithms (average discrepancy -0.4 ± 1.7%), including the Acuros XB algorithm also available with the Eclipse TPS. For slab phantom geometries (Level II audits), with similar measurement points downstream from inhomogeneities this discrepancy is also not seen. PMID:25921329

  16. 2004 Atomic and Molecular Interactions Gordon Research Conference

    SciTech Connect

    Dr. Paul J. Dagdigian

    2004-10-25

    The 2004 Gordon Research Conference on Atomic and Molecular Interactions was held July 11-16 at Colby-Sawyer College, New London, New Hampshire. This latest edition in a long-standing conference series featured invited talks and contributed poster papers on dynamics and intermolecular interactions in a variety of environments, ranging from the gas phase through surfaces and condensed media. A total of 90 conferees participated in the conference.

  17. Astronaut Richard F. Gordon Aboard Command Module Yankee Clipper

    NASA Technical Reports Server (NTRS)

    1969-01-01

    This is a view of astronaut Richard F. Gordon attaching a high resolution telephoto lens to a camera aboard the Apollo 12 Command Module (CM) Yankee Clipper. The second manned lunar landing mission, Apollo 12 launched from launch pad 39-A at Kennedy Space Center in Florida on November 14, 1969 via a Saturn V launch vehicle. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. Aboard Apollo 12 was a crew of three astronauts: Alan L. Bean, pilot of the Lunar Module (LM), Intrepid; Richard Gordon, pilot of the Command Module (CM), Yankee Clipper; and Spacecraft Commander Charles Conrad. The LM, Intrepid, landed astronauts Conrad and Bean on the lunar surface in what's known as the Ocean of Storms. Their lunar soil activities included the deployment of the Apollo Lunar Surface Experiments Package (ALSEP), finding the unmanned Surveyor 3 that landed on the Moon on April 19, 1967, and collecting 75 pounds (34 kilograms) of rock samples. Astronaut Richard Gordon piloted the CM, Yankee Clipper, in a parking orbit around the Moon. Apollo 12 safely returned to Earth on November 24, 1969.

  18. Asymmetric processing of a substrate protein in sequential allosteric cycles of AAA+ nanomachines

    NASA Astrophysics Data System (ADS)

    Kravats, Andrea N.; Tonddast-Navaei, Sam; Bucher, Ryan J.; Stan, George

    2013-09-01

    Essential protein quality control includes mechanisms of substrate protein (SP) unfolding and translocation performed by powerful ring-shaped AAA+ (ATPases associated with various cellular activities) nanomachines. These SP remodeling actions are effected by mechanical forces imparted by AAA+ loops that protrude into the central channel. Sequential intra-ring allosteric motions, which underlie repetitive SP-loop interactions, have been proposed to comprise clockwise (CW), counterclockwise (CCW), or random (R) conformational transitions of individual AAA+ subunits. To probe the effect of these allosteric mechanisms on unfoldase and translocase functions, we perform Langevin dynamics simulations of a coarse-grained model of an all-alpha SP processed by the single-ring ClpY ATPase or by the double-ring p97 ATPase. We find that, in all three allosteric mechanisms, the SP undergoes conformational transitions along a common set of pathways, which reveals that the active work provided by the ClpY machine involves single loop-SP interactions. Nevertheless, the rates and yields of SP unfolding and translocation are controlled by mechanism-dependent loop-SP binding events, as illustrated by faster timescales of SP processing in CW allostery compared with CCW and R allostery. The distinct efficacy of allosteric mechanisms is due to the asymmetric collaboration of adjacent subunits, which involves CW-biased structural motions of AAA+ loops and results in CW-compatible torque applied onto the SP. Additional simulations of mutant ClpY rings, which render a subset of subunits catalytically-defective or reduce their SP binding affinity, reveal that subunit-based conformational transitions play the major role in SP remodeling. Based on these results we predict that the minimally functional AAA+ ring includes three active subunits, only two of which are adjacent.

  19. Asymmetric processing of a substrate protein in sequential allosteric cycles of AAA+ nanomachines.

    PubMed

    Kravats, Andrea N; Tonddast-Navaei, Sam; Bucher, Ryan J; Stan, George

    2013-09-28

    Essential protein quality control includes mechanisms of substrate protein (SP) unfolding and translocation performed by powerful ring-shaped AAA+ (ATPases associated with various cellular activities) nanomachines. These SP remodeling actions are effected by mechanical forces imparted by AAA+ loops that protrude into the central channel. Sequential intra-ring allosteric motions, which underlie repetitive SP-loop interactions, have been proposed to comprise clockwise (CW), counterclockwise (CCW), or random (R) conformational transitions of individual AAA+ subunits. To probe the effect of these allosteric mechanisms on unfoldase and translocase functions, we perform Langevin dynamics simulations of a coarse-grained model of an all-alpha SP processed by the single-ring ClpY ATPase or by the double-ring p97 ATPase. We find that, in all three allosteric mechanisms, the SP undergoes conformational transitions along a common set of pathways, which reveals that the active work provided by the ClpY machine involves single loop-SP interactions. Nevertheless, the rates and yields of SP unfolding and translocation are controlled by mechanism-dependent loop-SP binding events, as illustrated by faster timescales of SP processing in CW allostery compared with CCW and R allostery. The distinct efficacy of allosteric mechanisms is due to the asymmetric collaboration of adjacent subunits, which involves CW-biased structural motions of AAA+ loops and results in CW-compatible torque applied onto the SP. Additional simulations of mutant ClpY rings, which render a subset of subunits catalytically-defective or reduce their SP binding affinity, reveal that subunit-based conformational transitions play the major role in SP remodeling. Based on these results we predict that the minimally functional AAA+ ring includes three active subunits, only two of which are adjacent.

  20. On the Klein-Gordon oscillator subject to a Coulomb-type potential

    NASA Astrophysics Data System (ADS)

    Bakke, K.; Furtado, C.

    2015-04-01

    By introducing the scalar potential as modification in the mass term of the Klein-Gordon equation, the influence of a Coulomb-type potential on the Klein-Gordon oscillator is investigated. Relativistic bound states solutions are achieved to both attractive and repulsive Coulomb-type potentials and the arising of a quantum effect characterized by the dependence of angular frequency of the Klein-Gordon oscillator on the quantum numbers of the system is shown.

  1. SFM-FDTD analysis of triangular-lattice AAA structure: Parametric study of the TEM mode

    NASA Astrophysics Data System (ADS)

    Hamidi, M.; Chemrouk, C.; Belkhir, A.; Kebci, Z.; Ndao, A.; Lamrous, O.; Baida, F. I.

    2014-05-01

    This theoretical work reports a parametric study of enhanced transmission through annular aperture array (AAA) structure arranged in a triangular lattice. The effect of the incidence angle in addition to the inner and outer radii values on the evolution of the transmission spectra is carried out. To this end, a 3D Finite-Difference Time-Domain code based on the Split Field Method (SFM) is used to calculate the spectral response of the structure for any angle of incidence. In order to work through an orthogonal unit cell which presents the advantage to reduce time and space of computation, special periodic boundary conditions are implemented. This study provides a new modeling of AAA structures useful for producing tunable ultra-compact devices.

  2. Geometrical factors influencing the hemodynamic behavior of the AAA stent grafts: essentials for the clinician.

    PubMed

    Georgakarakos, Efstratios; Argyriou, Christos; Schoretsanitis, Nikolaos; Ioannou, Chris V; Kontopodis, Nikolaos; Morgan, Robert; Tsetis, Dimitrios

    2014-12-01

    Endovascular aneurysm repair (EVAR) is considered to be the treatment of choice for abdominal aortic aneurysms (AAA). Despite the initial technical success, EVAR is amenable to early and late complications, among which the migration of the endograft (EG) with subsequent proximal endoleak (Type Ia) leads to repressurization of the AAA sac, exposure to excessive wall stress, and, hence, to potential rupture. This article discusses the influence that certain geometrical factors, such as neck angulation, iliac bifurcation, EG curvature, neck-to-iliac diameter, and length ratios, as well as iliac limbs configuration can exert on the hemodynamic behavior of the EGs. The information provided could help both clinicians and EG manufacturers towards further development and improvement of EG designs and better operational planning. PMID:24938906

  3. Substituent effects in double-helical hydrogen-bonded AAA-DDD complexes.

    PubMed

    Wang, Hong-Bo; Mudraboyina, Bhanu P; Wisner, James A

    2012-01-27

    Two series of DDD and AAA hydrogen-bond arrays were synthesized that form triply-hydrogen-bonded double-helical complexes when combined in CDCl(3) solution. Derivatization of the DDD arrays with electron-withdrawing groups increases the complex association constants by up to a factor of 30 in those arrays examined. Derivatization of the AAA arrays with electron donating substituents reveals a similar magnitude effect on the complex stabilities. The effect of substitution on both types of arrays are modeled quite satisfactorily (R(2) > 0.96 in all cases) as free energy relationships with respect to the sums of their Hammett substituent constants. In all, the complex stabilities can be manipulated over more than three orders of magnitude (>20 kJ mol(-1)) using this type of modification.

  4. Dosimetric comparison of Acuros XB, AAA, and XVMC in stereotactic body radiotherapy for lung cancer

    SciTech Connect

    Tsuruta, Yusuke; Nakata, Manabu; Higashimura, Kyoji; Nakamura, Mitsuhiro Matsuo, Yukinori; Monzen, Hajime; Mizowaki, Takashi; Hiraoka, Masahiro

    2014-08-15

    Purpose: To compare the dosimetric performance of Acuros XB (AXB), anisotropic analytical algorithm (AAA), and x-ray voxel Monte Carlo (XVMC) in heterogeneous phantoms and lung stereotactic body radiotherapy (SBRT) plans. Methods: Water- and lung-equivalent phantoms were combined to evaluate the percentage depth dose and dose profile. The radiation treatment machine Novalis (BrainLab AG, Feldkirchen, Germany) with an x-ray beam energy of 6 MV was used to calculate the doses in the composite phantom at a source-to-surface distance of 100 cm with a gantry angle of 0°. Subsequently, the clinical lung SBRT plans for the 26 consecutive patients were transferred from the iPlan (ver. 4.1; BrainLab AG) to the Eclipse treatment planning systems (ver. 11.0.3; Varian Medical Systems, Palo Alto, CA). The doses were then recalculated with AXB and AAA while maintaining the XVMC-calculated monitor units and beam arrangement. Then the dose-volumetric data obtained using the three different radiation dose calculation algorithms were compared. Results: The results from AXB and XVMC agreed with measurements within ±3.0% for the lung-equivalent phantom with a 6 × 6 cm{sup 2} field size, whereas AAA values were higher than measurements in the heterogeneous zone and near the boundary, with the greatest difference being 4.1%. AXB and XVMC agreed well with measurements in terms of the profile shape at the boundary of the heterogeneous zone. For the lung SBRT plans, AXB yielded lower values than XVMC in terms of the maximum doses of ITV and PTV; however, the differences were within ±3.0%. In addition to the dose-volumetric data, the dose distribution analysis showed that AXB yielded dose distribution calculations that were closer to those with XVMC than did AAA. Means ± standard deviation of the computation time was 221.6 ± 53.1 s (range, 124–358 s), 66.1 ± 16.0 s (range, 42–94 s), and 6.7 ± 1.1 s (range, 5–9 s) for XVMC, AXB, and AAA, respectively. Conclusions: In the

  5. The Drug Diazaborine Blocks Ribosome Biogenesis by Inhibiting the AAA-ATPase Drg1*

    PubMed Central

    Loibl, Mathias; Klein, Isabella; Prattes, Michael; Schmidt, Claudia; Kappel, Lisa; Zisser, Gertrude; Gungl, Anna; Krieger, Elmar; Pertschy, Brigitte; Bergler, Helmut

    2014-01-01

    The drug diazaborine is the only known inhibitor of ribosome biogenesis and specifically blocks large subunit formation in eukaryotic cells. However, the target of this drug and the mechanism of inhibition were unknown. Here we identify the AAA-ATPase Drg1 as a target of diazaborine. Inhibitor binding into the second AAA domain of Drg1 requires ATP loading and results in inhibition of ATP hydrolysis in this site. As a consequence the physiological activity of Drg1, i.e. the release of Rlp24 from pre-60S particles, is blocked, and further progression of cytoplasmic preribosome maturation is prevented. Our results identify the first target of an inhibitor of ribosome biogenesis and provide the mechanism of inhibition of a key step in large ribosomal subunit formation. PMID:24371142

  6. Indications for and outcome of open AAA repair in the endovascular era.

    PubMed

    Wieker, Carola M; Spazier, Max; Böckler, Dittmar

    2016-04-01

    The benefits, safety and efficacy of endovascular aortic aneurysm repair (EVAR) is well documented and intensively reported in multiple randomized trials and meta-analysis. Therefore, EVAR became the first choice of abdominal aortic aneurysms (AAA) treatment in almost 70-100% of patients. Consecutively, open repair (OR) is performed less frequently in morphologically preselected patients. Anatomical condition remains the most important factor for indication for OR. Especially unfavorable intrarenal landing zone based on difficult neck anatomy like very short neck or excessive neck angulation is still the most predictive factor. Furthermore, patients presenting additional iliac aneurysms, aortoiliac occlusive disease or variations of renal arteries are recommended for OR. Randomized trials like EVAR 1, DREAM and OVER from the year 2004/2005 and 2009 showed lower 30-day mortality rates in EVAR compared to OR. However, the late mortality rates after two years became equal in both treatment options. Furthermore, reinterventions after EVAR occur more frequently than after OR. Analysis from our own data showed a higher 30-day mortality in the patients who underwent OR in the endovascular era (15% vs. 2.5%), however the number of emergency open AAA repair because of ruptured aneurysms was much higher in the endovascular era (32.5% vs. 5%). In conclusion, treatment of AAA has changed in the past decade. Nevertheless OR of AAA still remains as a safe and durable method in experienced surgeons, even in the endovascular era. High volume centres are needed to offer the best patients' treatment providing the best postoperative outcome. Therefore OR must remain a part of fellowship training in the future. To decide the best treatment option many facts like patients' fitness and preference or finally the anatomic suitability for endovascular repair have to be considered. PMID:26822580

  7. Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis.

    PubMed

    Tan, Dongyan; Blok, Neil B; Rapoport, Tom A; Walz, Thomas

    2016-03-01

    The Pex1 and Pex6 proteins are members of the AAA family of ATPases and are involved in peroxisome biogenesis. Recently, cryo-electron microscopy structures of the Pex1-Pex6 complex in different nucleotide states have been determined. This Structural Snapshot describes the structural features of the complex and their implications for its function, as well as questions that still await answers.

  8. Creating Value from Innovation: Laura Gordon-Murnane--Bureau of National Affairs

    ERIC Educational Resources Information Center

    Library Journal, 2005

    2005-01-01

    Some corporate executives regard their libraries as black holes that just consume company resources, but thanks to Laura Gordon-Murnane, executives at the Bureau of National Affairs (BNA) know their library actively adds value to the company. As web master for BNA's intranet, Gordon-Murnane creates information tools, databases, and products for…

  9. MA-9 ASTRONAUT L. GORDON COOPER LEAVES TRANSFER VAN AT LAUNCH COMPLEX 14

    NASA Technical Reports Server (NTRS)

    1963-01-01

    MA-9 ASTRONAUT L. GORDON COOPER LEAVES TRANSFER VAN AT LAUNCH COMPLEX 14 S-63-6247 P-07136, ARCHIVE-03808 Astronaut L. Gordon Cooper, Jr., leaves the transfer van at Pad #14 for his ride up the gantry elevator to the 11th deck where he will be inserted into the spacecraft for his 22-orbit mission.

  10. The Affirmative Development of Academic Ability: A Response to Edmund Gordon

    ERIC Educational Resources Information Center

    Lee, Carol D.

    2006-01-01

    This article presents the author's response to Edmund Gordon and Beatrice Bridglall's paper titled "The Affirmative Development of Academic Ability: In Pursuit of Social Justice." Placing her comments in a historical context, the author states that Gordon and Bridglall point out that the "Brown v. Board of Education" case was the result of decades…

  11. 2009 Epigenetics Gordon Research Conference (August 9 - 14, 2009)

    SciTech Connect

    Jeanie Lee

    2009-08-14

    Epigenetics refers to the study of heritable changes in genome function that occur without a change in primary DNA sequence. The 2009 Gordon Conference in Epigenetics will feature discussion of various epigenetic phenomena, emerging understanding of their underlying mechanisms, and the growing appreciation that human, animal, and plant health all depend on proper epigenetic control. Special emphasis will be placed on genome-environment interactions particularly as they relate to human disease. Towards improving knowledge of molecular mechanisms, the conference will feature international leaders studying the roles of higher order chromatin structure, noncoding RNA, repeat elements, nuclear organization, and morphogenic evolution. Traditional and new model organisms are selected from plants, fungi, and metazoans.

  12. Summary of completed project: 1991 Atmospheric Chemistry Gordon Research Conference

    SciTech Connect

    1995-04-01

    The focus of the Gordon Conference on Atmospheric Chemistry was to address and discuss several timely issues involving regional, continental and global scale chemical processes in both the troposphere and the stratosphere. These issues included photochemical pollution, tropospheric oxidative capacity, acid formation and deposition, greenhouse gas build-up, cloud and aerosol effects on chemical and radiation, biogeochemical cycling of trace atmospheric species and stratospheric ozone depletion. The technical sessions were organized along the topical lines used to define the US Global Tropospheric Chemistry Program with an added Policy and Perspective topic.

  13. Characterization of ATPase activity of the AAA ARC from Bifidobacterium longum subsp. infantis.

    PubMed

    Guzmán-Rodríguez, Mabel; de la Rosa, Ana Paulina Barba; Santos, Leticia

    2015-01-01

    Bifidobacteria are considered to be probiotics that exist in the large intestine and are helpful to maintain human health. Oral administration of bifidobacteria may be effective in improving the intestinal flora and environment, stimulating the immune response and possibly preventing cancer. However, for consistent and positive results, further well-controlled studies are urgently needed to describe the basic mechanisms of this microorganism. Analysis of the proteasome-lacking Bifidobacterium longum genome reveals that it possesses a gene, IPR003593 AAA ATPase core, which codes a 56 kDa protein containing one AAA ATPase domain. Phylogenetic classification made by CLANS, positioned this sequence into the ARC divergent branch of the AAA ATPase family of proteins. N-terminal analysis of the sequence indicates this protein is closely related to other ATPases such as the Rhodococcus erythropolis ARC, Archaeoglobus fulgidus PAN, Mycobacterium tuberculosis Mpa and the human proteasomal Rpt1 subunit. This gene was cloned, the full-length recombinant protein was overexpressed in Escherichia coli, purified as a high-molecular size complex and named Bl-ARC. Enzymatic characterization showed that Bl-ARC ATPase is active, Mg(+2)-dependent and sensitive to N-ethylmaleimide. Gene organization positions bl-arc in a region flanked by a cluster of genes that includes pup, dop and pafA genes. These findings point to a possible function as a chaperone in the degradation pathway via pupylation.

  14. An atypical AAA+ ATPase assembly controls efficient transposition through DNA remodeling and transposase recruitment

    PubMed Central

    Arias-Palomo, Ernesto; Berger, James M.

    2015-01-01

    Transposons are ubiquitous genetic elements that drive genome rearrangements, evolution, and the spread of infectious disease and drug-resistance. Many transposons, such as Mu, Tn7 and IS21, require regulatory AAA+ ATPases for function. We use x-ray crystallography and cryo-electron microscopy to show that the ATPase subunit of IS21, IstB, assembles into a clamshell-shaped decamer that sandwiches DNA between two helical pentamers of ATP-associated AAA+ domains, sharply bending the duplex into a 180° U-turn. Biochemical studies corroborate key features of the structure, and further show that the IS21 transposase, IstA, recognizes the IstB•DNA complex and promotes its disassembly by stimulating ATP hydrolysis. Collectively, these studies reveal a distinct manner of higher-order assembly and client engagement by a AAA+ ATPase and suggest a mechanistic model where IstB binding and subsequent DNA bending primes a selected insertion site for efficient transposition. PMID:26276634

  15. Structural basis for DNA-mediated allosteric regulation facilitated by the AAA+ module of Lon protease.

    PubMed

    Lee, Alan Yueh-Luen; Chen, Yu-Da; Chang, Yu-Yung; Lin, Yu-Ching; Chang, Chi-Fon; Huang, Shing-Jong; Wu, Shih-Hsiung; Hsu, Chun-Hua

    2014-02-01

    Lon belongs to a unique group of AAA+ proteases that bind DNA. However, the DNA-mediated regulation of Lon remains elusive. Here, the crystal structure of the α subdomain of the Lon protease from Brevibacillus thermoruber (Bt-Lon) is presented, together with biochemical data, and the DNA-binding mode is delineated, showing that Arg518, Arg557 and Arg566 play a crucial role in DNA binding. Electrostatic interactions contributed by arginine residues in the AAA+ module are suggested to be important to DNA binding and allosteric regulation of enzymatic activities. Intriguingly, Arg557, which directly binds DNA in the α subdomain, has a dual role in the negative regulation of ATPase stimulation by DNA and in the domain-domain communication in allosteric regulation of Bt-Lon by substrate. In conclusion, structural and biochemical evidence is provided to show that electrostatic interaction in the AAA+ module is important for DNA binding by Lon and allosteric regulation of its enzymatic activities by DNA and substrate.

  16. Subunit dynamics and nucleotide-dependent asymmetry of an AAA(+) transcription complex.

    PubMed

    Zhang, Nan; Gordiyenko, Yuliya; Joly, Nicolas; Lawton, Edward; Robinson, Carol V; Buck, Martin

    2014-01-01

    Bacterial enhancer binding proteins (bEBPs) are transcription activators that belong to the AAA(+) protein family. They form higher-order self-assemblies to regulate transcription initiation at stress response and pathogenic promoters. The precise mechanism by which these ATPases utilize ATP binding and hydrolysis energy to remodel their substrates remains unclear. Here we employed mass spectrometry of intact complexes to investigate subunit dynamics and nucleotide occupancy of the AAA(+) domain of one well-studied bEBP in complex with its substrate, the σ(54) subunit of RNA polymerase. Our results demonstrate that the free AAA(+) domain undergoes significant changes in oligomeric states and nucleotide occupancy upon σ(54) binding. Such changes likely correlate with one transition state of ATP and are associated with an open spiral ring formation that is vital for asymmetric subunit function and interface communication. We confirmed that the asymmetric subunit functionality persists for open promoter complex formation using single-chain forms of bEBP lacking the full complement of intact ATP hydrolysis sites. Outcomes reconcile low- and high-resolution structures and yield a partial sequential ATP hydrolysis model for bEBPs. PMID:24055699

  17. Functional characterization of fidgetin, an AAA-family protein mutated in fidget mice

    SciTech Connect

    Yang Yan; Mahaffey, Connie L.; Berube, Nathalie; Nystuen, Arne; Frankel, Wayne N. . E-mail: wnf@jax.org

    2005-03-10

    The mouse fidget mutation is an autosomal recessive mutation that renders reduced or absent semicircular canals, microphthalmia, and various skeletal abnormalities to affected mice. We previously identified the defective gene which encodes fidgetin, a new member of the ATPases associated with diverse cellular activities (AAA proteins). Here, we report on the subcellular localization of fidgetin as well as that of two closely related proteins, fidgetin-like 1 and fidgetin-like 2. Epitope-tagging and immunostaining revealed that both fidgetin and fidgetin-like 2 were predominantly localized to the nucleus, whereas fidgetin-like 1 was both nuclear and cytoplasmic. Furthermore, deletion studies identified a putative bipartite nuclear localization signal in the middle portion of the fidgetin protein. Since AAA proteins are known to form functional hetero- or homo-hexamers, we used reciprocal immunoprecipitation to examine the potential interaction among these proteins. We found that fidgetin interacted with itself and this specific interaction was abolished when either the N- or C-terminus of the protein was truncated. Taken together, our results suggest that fidgetin is a nuclear AAA-family protein with the potential to form homo-oligomers, thus representing the first step towards the elucidation of fidgetin's cellular function and the disease mechanism in fidget mutant mice.

  18. Molecular snapshots of the Pex1/6 AAA+ complex in action

    PubMed Central

    Ciniawsky, Susanne; Grimm, Immanuel; Saffian, Delia; Girzalsky, Wolfgang; Erdmann, Ralf; Wendler, Petra

    2015-01-01

    The peroxisomal proteins Pex1 and Pex6 form a heterohexameric type II AAA+ ATPase complex, which fuels essential protein transport across peroxisomal membranes. Mutations in either ATPase in humans can lead to severe peroxisomal disorders and early death. We present an extensive structural and biochemical analysis of the yeast Pex1/6 complex. The heterohexamer forms a trimer of Pex1/6 dimers with a triangular geometry that is atypical for AAA+ complexes. While the C-terminal nucleotide-binding domains (D2) of Pex6 constitute the main ATPase activity of the complex, both D2 harbour essential substrate-binding motifs. ATP hydrolysis results in a pumping motion of the complex, suggesting that Pex1/6 function involves substrate translocation through its central channel. Mutation of the Walker B motif in one D2 domain leads to ATP hydrolysis in the neighbouring domain, giving structural insights into inter-domain communication of these unique heterohexameric AAA+ assemblies. PMID:26066397

  19. Functional characterization of fidgetin, an AAA-family protein mutated in fidget mice.

    PubMed

    Yang, Yan; Mahaffey, Connie L; Bérubé, Nathalie; Nystuen, Arne; Frankel, Wayne N

    2005-03-10

    The mouse fidget mutation is an autosomal recessive mutation that renders reduced or absent semicircular canals, microphthalmia, and various skeletal abnormalities to affected mice. We previously identified the defective gene which encodes fidgetin, a new member of the ATPases associated with diverse cellular activities (AAA proteins). Here, we report on the subcellular localization of fidgetin as well as that of two closely related proteins, fidgetin-like 1 and fidgetin-like 2. Epitope-tagging and immunostaining revealed that both fidgetin and fidgetin-like 2 were predominantly localized to the nucleus, whereas fidgetin-like 1 was both nuclear and cytoplasmic. Furthermore, deletion studies identified a putative bipartite nuclear localization signal in the middle portion of the fidgetin protein. Since AAA proteins are known to form functional hetero- or homo-hexamers, we used reciprocal immunoprecipitation to examine the potential interaction among these proteins. We found that fidgetin interacted with itself and this specific interaction was abolished when either the N- or C-terminus of the protein was truncated. Taken together, our results suggest that fidgetin is a nuclear AAA-family protein with the potential to form homo-oligomers, thus representing the first step towards the elucidation of fidgetin's cellular function and the disease mechanism in fidget mutant mice.

  20. Experimental and computational studies on the flow fields in aortic aneurysms associated with deployment of AAA stent-grafts

    NASA Astrophysics Data System (ADS)

    Zhang, Xiwen; Yao, Zhaohui; Zhang, Yan; Xu, Shangdong

    2007-10-01

    Pulsatile flow fields in rigid abdominal aortic aneurysm (AAA) models were investigated numerically, and the simulation results are found in good agreement with particle image velocimetry (PIV) measurements. There are one or more vortexes in the AAA bulge, and a fairly high wall shear stress exists at the distal end, and thus the AAA is in danger of rupture. Medical treatment consists of inserting a vascular stent-graft in the AAA, which would decrease the blood impact to the inner walls and reduce wall shear stress so that the rupture could be prevented. A new computational model, based on porous medium model, was developed and results are documented. Therapeutic effect of the stent-graft was verified numerically with the new model.

  1. On the Klein–Gordon oscillator subject to a Coulomb-type potential

    SciTech Connect

    Bakke, K. Furtado, C.

    2015-04-15

    By introducing the scalar potential as modification in the mass term of the Klein–Gordon equation, the influence of a Coulomb-type potential on the Klein–Gordon oscillator is investigated. Relativistic bound states solutions are achieved to both attractive and repulsive Coulomb-type potentials and the arising of a quantum effect characterized by the dependence of angular frequency of the Klein–Gordon oscillator on the quantum numbers of the system is shown. - Highlights: • Interaction between the Klein–Gordon oscillator and a modified mass term. • Relativistic bound states for both attractive and repulsive Coulomb-type potentials. • Dependence of the Klein–Gordon oscillator frequency on the quantum numbers. • Relativistic analogue of a position-dependent mass system.

  2. 2012 WATER & AQUEOUS SOLUTIONS GORDON RESEARCH CONFERENCE (GRC) AND GORDON RESEARCH SEMINAR (GRS), AUG 10-17, 2012

    SciTech Connect

    Dor Ben-Amotz, PI

    2012-08-17

    Understanding the fundamental principles governing the structure and dynamics of water - and particularly how water mediates chemical interactions and processes - continues to pose formidable challenges and yield abundant surprises. The focus of this Gordon Research Conference is on identifying key questions, describing emerging understandings, and unveiling surprising discoveries related to water and aqueous solutions. The talks and posters at this meeting will describe studies of water and its interactions with objects such as interfaces, channels, electrons, oils, ions, and proteins; probed using optical, electrical, and particle experiments, and described using classical, quantum, and multi-scale theories.

  3. Breather-like structures in modified sine-Gordon models

    NASA Astrophysics Data System (ADS)

    Ferreira, L. A.; Zakrzewski, Wojtek J.

    2016-05-01

    We report analytical and numerical results on breather-like field configurations in a theory which is a deformation of the integrable sine-Gordon model in (1  +  1) dimensions. The main motivation of our study is to test the ideas behind the recently proposed concept of quasi-integrability, which emerged from the observation that some field theories possess an infinite number of quantities which are asymptotically conserved in the scattering of solitons, and periodic in time in the case of breather-like configurations. Even though the mechanism responsible for such phenomena is not well understood yet, it is clear that special properties of the solutions under a space-time parity transformation play a crucial role. The numerical results of the present paper give support for the ideas on quasi-integrability, as it is found that extremely long-lived breather configurations satisfy these parity properties. We also report on a mechanism, particular to the theory studied here, that favours the existence of long lived breathers even in cases of significant deformations of the sine-Gordon potential. We also find numerically that our breather-like configurations decay through the gradual increase of their frequency of oscillations.

  4. 1998 Gordon Research Conference on Gravitational Effects on Living Systems

    NASA Technical Reports Server (NTRS)

    Evans, Michael L.

    1998-01-01

    The Gordon Research Conference (GRC) on GRAVITATIONAL EFFECTS ON LIVING SYSTEMS was held at COLBY SAYWER 2 from 7/12/98 thru 7/17/98. The Conference was well-attended with 94 participants (attendees list attached). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. Attached is a copy of the formal schedule and speaker program and the poster program. In addition to these formal interactions, "free time" was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field. As you know, in the interest of promoting the presentation of unpublished and frontier-breaking research, Gordon Research Conferences does not permit publication of meeting proceedings.

  5. Extended Klein-Gordon action, gravity and nonrelativistic fluid

    SciTech Connect

    Hassaiene, Mokhtar

    2006-03-15

    We consider a scalar field action for which the Lagrangian density is a power of the massless Klein-Gordon Lagrangian. The coupling of gravity to this matter action is considered. In this case, we show the existence of nontrivial scalar field configurations with vanishing energy-momentum tensor on any static, spherically symmetric vacuum solutions of the Einstein equations. These configurations in spite of being coupled to gravity do not affect the curvature of space-time. The properties of this particular matter action are also analyzed. For a particular value of the exponent, the extended Klein-Gordon action is shown to exhibit a conformal invariance without requiring the introduction of a nonminimal coupling. We also establish a correspondence between this action and a nonrelativistic isentropic fluid in one fewer dimension. This fluid can be identified with the (generalized) Chaplygin gas for a particular value of the power. It is also shown that the nonrelativistic fluid admits, apart from the Galileo symmetry, an additional symmetry whose action is a rescaling of the time.

  6. Criticality in self-dual sine-Gordon models

    NASA Astrophysics Data System (ADS)

    Lecheminant, P.; Gogolin, Alexander O.; Nersesyan, Alexander A.

    2002-09-01

    We discuss the nature of criticality in the β2=2 πN self-dual extension of the sine-Gordon model. This field theory is related to the two-dimensional classical XY model with a N-fold degenerate symmetry-breaking field. We briefly overview the already studied cases N=2,4 and analyze in detail the case N=3 where a single phase transition in the three-state Potts universality class is expected to occur. The Z3 infrared critical properties of the β2=6 π self-dual sine-Gordon model are derived using two non-perturbative approaches. On one hand, we map the model onto an integrable deformation of the Z4 parafermion theory. The latter is known to flow to a massless Z3 infrared fixed point. Another route is based on the connection with a chirally asymmetric, su(2) 4⊗su(2) 1 Wess-Zumino-Novikov-Witten model with anisotropic current-current interaction, where we explore the existence of a decoupling (Toulouse) point.

  7. Resonant phase dynamics in 0- π Sine-Gordon facets

    NASA Astrophysics Data System (ADS)

    Rotoli, Giacomo; Stornaiuolo, Daniela; Cedergren, Karin; Leo, Antonio; Bauch, Thilo; Lombardi, Filomena; Tafuri, Francesco

    2015-09-01

    A locally phase-shifted Sine-Gordon model well accounts for the phenomenology of unconventional Josephson junctions. The phase dynamics shows resonant modes similar to Fiske modes that appear both in the presence and in the absence of the external magnetic field in standard junctions. In the latter case, they are also in competition with zero field propagation of Sine-Gordon solitons, i.e., fluxons, which give rise to the so-called zero field steps in the current-voltage (I-V) of the junction. We numerically study the I-V characteristics and the resonances magnetic field patterns for some different faceting configurations, in various dissipative regimes, as a function of temperature. The simulated dynamics of the phase is analyzed for lower-order resonances. We give evidence of a nontrivial dynamics due to the interaction of propagating fluxons with localized semifluxons. Numerical results are compared with experimental outcomes obtained on high-quality high-Tc grain boundary YBCO junctions.

  8. [Gordon syndrome: The importance of measuring blood pressure in children].

    PubMed

    Bruel, A; Vargas-Poussou, R; Jeunemaitre, X; Labbe, A; Merlin, E; Bessenay, L

    2016-08-01

    Gordon's syndrome, or type II pseudo-hypoaldosteronism, is a rare cause of arterial hypertension in children. However, it is important to diagnose this syndrome because of the spectacular efficacy of thiazide diuretics. The typical clinical picture of Gordon syndrome includes, apart from arterial hypertension and dyskaliemia, hyperchloremia metabolic acidosis, hypercalciuria, a low rate of renin, and most frequently, a normal or high rate of aldosterone. Dental abnormalities and growth retardation can also be associated. In most cases, it is inherited in an autosomal dominant pattern. We report on a 7-year-old girl who was discovered with arterial hypertension during a consultation for chronic diarrhea. The association of growth retardation, hyperkaliemia, and metabolic acidosis oriented the diagnosis. Starting a thiazide diuretic helped control the arterial hypertension and the kaliemia in a spectacular manner. The genetic analysis proved the existence of a splice mutation on exon 9 of the CUL3 gene coding for cullin 3. This mutation is de novo. PMID:27369102

  9. Dissipative effects in nonlinear Klein-Gordon dynamics

    NASA Astrophysics Data System (ADS)

    Plastino, A. R.; Tsallis, C.

    2016-03-01

    We consider dissipation in a recently proposed nonlinear Klein-Gordon dynamics that admits exact time-dependent solutions of the power-law form e_qi(kx-wt) , involving the q-exponential function naturally arising within the nonextensive thermostatistics (e_qz \\equiv [1+(1-q)z]1/(1-q) , with e_1^z=ez ). These basic solutions behave like free particles, complying, for all values of q, with the de Broglie-Einstein relations p=\\hbar k , E=\\hbar ω and satisfying a dispersion law corresponding to the relativistic energy-momentum relation E2 = c^2p2 + m^2c4 . The dissipative effects explored here are described by an evolution equation that can be regarded as a nonlinear generalization of the celebrated telegraph equation, unifying within one single theoretical framework the nonlinear Klein-Gordon equation, a nonlinear Schrödinger equation, and the power-law diffusion (porous-media) equation. The associated dynamics exhibits physically appealing traveling solutions of the q-plane wave form with a complex frequency ω and a q-Gaussian square modulus profile.

  10. Structural Insights into the Unusually Strong ATPase Activity of the AAA Domain of the Caenorhabditis elegans Fidgetin-like 1 (FIGL-1) Protein*

    PubMed Central

    Peng, Wentao; Lin, Zhijie; Li, Weirong; Lu, Jing; Shen, Yuequan; Wang, Chunguang

    2013-01-01

    The FIGL-1 (fidgetin like-1) protein is a homolog of fidgetin, a protein whose mutation leads to multiple developmental defects. The FIGL-1 protein contains an AAA (ATPase associated with various activities) domain and belongs to the AAA superfamily. However, the biological functions and developmental implications of this protein remain unknown. Here, we show that the AAA domain of the Caenorhabditis elegans FIGL-1 protein (CeFIGL-1-AAA), in clear contrast to homologous AAA domains, has an unusually high ATPase activity and forms a hexamer in solution. By determining the crystal structure of CeFIGL-1-AAA, we found that the loop linking helices α9 and α10 folds into the short helix α9a, which has an acidic surface and interacts with a positively charged surface of the neighboring subunit. Disruption of this charge interaction by mutagenesis diminishes both the ATPase activity and oligomerization capacity of the protein. Interestingly, the acidic residues in helix α9a of CeFIGL-1-AAA are not conserved in other homologous AAA domains that have relatively low ATPase activities. These results demonstrate that the sequence of CeFIGL-1-AAA has adapted to establish an intersubunit charge interaction, which contributes to its strong oligomerization and ATPase activity. These unique properties of CeFIGL-1-AAA distinguish it from other homologous proteins, suggesting that CeFIGL-1 may have a distinct biological function. PMID:23979136

  11. 2012 MICROBIAL STRESS RESPONSE GORDON RESEARCH CONFERENCE, JULY 20-25, 2012

    SciTech Connect

    Timothy Donohue

    2012-07-25

    The Gordon Research Conference on MICROBIAL STRESS RESPONSE was held at Mount Holyoke College, South Hadley, Massachusetts, July 15-20, 2012. The Conference was well-attended with 180 participants. The 2012 Microbial Stress Responses Gordon Research Conference will provide a forum for the open reporting of recent discoveries on the diverse mechanisms employed by microbes to respond to stress. Approaches range from analysis at the molecular level (how are signals perceived and transmitted to change gene expression or function) to cellular and microbial community responses. Gordon Research Conferences does not permit publication of meeting proceedings.

  12. Relativistic quantum effects of confining potentials on the Klein-Gordon oscillator

    NASA Astrophysics Data System (ADS)

    Vitória, R. L. L.; Bakke, K.

    2016-02-01

    The behaviour of the Klein-Gordon oscillator under the influence of linear and Coulomb-type potentials is investigated. The introduction of the scalar potentials is made by modifying the mass term of the Klein-Gordon equation, then, by searching for relativistic bound states, a particular quantum effect can be observed: a dependence of the angular frequency of the Klein-Gordon oscillator on the quantum numbers associated with the radial modes and the angular momentum. As an example, we analyse the angular frequency and the energy level associated with the ground state of the relativistic system.

  13. NASA Astrophysics E/PO Impact: NASA SOFIA AAA Program Evaluation Results

    NASA Astrophysics Data System (ADS)

    Harman, Pamela; Backman, Dana E.; Clark, Coral; Inverness Research Sofia Aaa Evaluation Team, Wested Sofia Aaa Evaluation Team

    2015-01-01

    SOFIA is an airborne observatory, studying the universe at infrared wavelengths, capable of making observations that are impossible for even the largest and highest ground-based telescopes. SOFIA also inspires the development of new scientific instrumentation and fosters the education of young scientists and engineers.SOFIA is an 80% - 20% partnership of NASA and the German Aerospace Center (DLR), consisting of an extensively modified Boeing 747SP aircraft carrying a reflecting telescope with an effective diameter of 2.5 meters (100 inches). The SOFIA aircraft is based at NASA Armstrong Flight Research Center, Building 703, in Palmdale, California. The Science Program and Outreach Offices are located at NASA Ames Research center. SOFIA is a program in NASA's Science Mission Directorate, Astrophysics Division.Data will be collected to study many different kinds of astronomical objects and phenomena, including star cycles, solar system formation, identification of complex molecules in space, our solar system, galactic dust, nebulae and ecosystems.Airborne Astronomy Ambassador (AAA) Program:The SOFIA Education and Communications program exploits the unique attributes of airborne astronomy to contribute to national goals for the reform of science, technology, engineering, and math (STEM) education, and to elevate public scientific and technical literacy.The AAA effort is a professional development program aspiring to improve teaching, inspire students, and inform the community. To date, 55 educators from 21 states; Cycles 0, 1 and 2; have completed their astronomy professional development and their SOFIA science flight experience. Evaluation has confirmed the program's positive impact on the teacher participants, on their students, and in their communities. The inspirational experience has positively impacted their practice and career trajectory. AAAs have incorporated content knowledge and specific components of their experience into their curricula, and have given

  14. Morphological State as a Predictor for Reintervention and Mortality After EVAR for AAA

    SciTech Connect

    Ohrlander, Tomas; Dencker, Magnus; Acosta, Stefan

    2012-10-15

    Purpose: This study was designed to assess aorto-iliac morphological characteristics in relation to reintervention and all-cause long-term mortality in patients undergoing standard EVAR for infrarenal AAA. Methods: Patients treated with EVAR (Zenith{sup Registered-Sign} Stentgrafts, Cook) between May 1998 and February 2006 were prospectively enrolled in a computerized database where comorbidities and preoperative aneurysm morphology were entered. Reinterventions and mortality were checked until December 1, 2010. Median follow-up time was 68 months. Results: A total of 304 patients were included, of which 86% were men. Median age was 74 years. The reintervention rate was 23.4% (71/304). A greater diameter of the common iliac artery (p = 0.037; hazard ratio (HR) 1.037 [1.002-1.073]) was an independent factor for an increased number of reinterventions. The 30-day mortality rate was 3.0% (9/304). Aneurysm-related deaths due to AAA occurred in 4.9% (15/304). Five patients died due to a concomitant ruptured thoracic aortic aneurysm. The mortality until end of follow-up was 54.3% (165/304). The proportion of deaths caused by vascular diseases was 61.6%. The severity of angulation of the iliac arteries (p = 0.014; HR 1.018 [95% confidence interval (CI) 1.004-1.033]) and anemia (p = 0.044; HR 2.79 [95% CI 1.029-7.556]) remained as independent factors associated with all-cause long-term mortality. The crude reintervention-free survival rate at 1, 3, and 5 years was 84.5%, 64.8%, and 51.6%, respectively. Conclusions: The initial aorto-iliac morphological state in patients scheduled for standard EVAR for AAA seems to be strongly related to the need for reinterventions and long-term mortality.

  15. SU-E-P-16: A Feasibility Study of Using Eclipse AAA for SRS Treatement

    SciTech Connect

    Lim, S; LoSasso, T

    2015-06-15

    Purpose: To commission Varian Eclipse AAA for SRS treatment and compare the accuracy with Brainlab iPlan system for clinical cases measured with radiochromic film. Methods: A 6MV AAA clinical model for a Varian TrueBeam STx is used as baseline. The focal spot and field size of the baseline model(BASE) are (1.75,0.75) and 40×40cm{sup 2} respectively. Maximum field sizes, output factors(S{sub t}), FWHM focal spot and secondary source sizes are systematically adjusted to obtain an optimized model(OPT) by comparing the calculated PDD’s, profiles, and output factors with measurements taken with a stereotactic diode(SD) and, cc01 and cc04 ion chambers in Blue Phantom. In-phantom dose distributions of clinical SRS fields are calculated using the OPT and the clinical Brainlab iPlan pencil-beam. Within the 90% isodose-line(ROI), the average dose difference between the calculations and radiochromic film measurements are assessed. Results: The maximum field, focal spot and secondary source sizes for the OPT are 15×15cm{sup 2}, (0,0), and 32.3mm respectively. The OPT St input at 1.0 and 2.0cm fields are increased by 4.5% and 1.5% from BASE. The calculated output of the BASE and OPT underestimate by 16.1%–3.2% respectively at 0.5×0.5cm{sup 2} field and 3.1%−0.02% respectively at 1.0×1.0cm{sup 2} field. The depth doses at 10cm are within 3.5% and 0.4% of measurements for 0.5×0.5 and 1.0×1.0cm{sup 2}. The ROI dose of OPT and iPlan are within 1.6% and 0.6% of film measurements for 3.0cm clinical fields. For 1.0cm fields, the ROI dose of OPT underestimate 0.0–2.0% and iPlan overestimates 1.7–2.9% relative to measurements. Conclusion: The small field dose calculation of Eclipse AAA algorithm can be significantly improved by carefully adjusting the input parameters. The larger deviation of the OPT for 0.5×0.5cm{sup 2} field from measurements can be attributed to the lowest 1.0cm field size input limit of AAA. The OPT compares reasonably well with the iPlan pencil

  16. Philip G. Zimbardo on his career and the Stanford Prison Experiment's 40th anniversary. Interview by Scott Drury, Scott A. Hutchens, Duane E. Shuttlesworth, and Carole L. White.

    PubMed

    Zimbardo, Philip G

    2012-05-01

    We interviewed Philip G. Zimbardo on April 19, 2011, in anticipation of the 40th anniversary of the Stanford Prison Experiment in August 2011. While Zimbardo's name is mentioned often in tandem with the experiment, he has distinguished himself in many other areas within psychology before and after the experiment, beginning with an accomplished early career at New York University in which he took interest in social psychology research on deindividuation. We discussed the Stanford Prison Experiment in the greater context of his varied and illustrious career, including recent pioneering work on heroism, the establishment of The Shyness Clinic at Stanford University, and the iconic Discovering Psychology series. We also addressed his adroit and candid approach to the experiment itself over the years.

  17. Gordon Research Conference on Holography and Optical Information Processing

    NASA Astrophysics Data System (ADS)

    Walkup, John F.

    1991-09-01

    The 1991 Gordon Research Conference on Holography and Optical Information Processing was held on 17-21 June, 1991 at Plymouth State College in Plymouth, NH. The talks on Ultrafast Optical Logic Using Solitons and Optical Processing with Planar Optics pointed out the significant progress being made by various Bell Labs investigators on various aspects of optical computing. Professor Sing Lee from the University of California-San Diego gave an excellent overview of some engineering and performance Issues in optoelectronic computing. It is clear that the Soviets have made considerable progress on multi transducer acousto-optic spectrum analyzers. It is also clear that the Japanese government is planning to continue to make optical computing one of its high priority areas, with its NIPT (New Information Processing Technology project), and are projected to continue to investigate so called sixth generation computer technologies.

  18. Zero temperature landscape of the random sine-Gordon model

    SciTech Connect

    Sanchez, A.; Bishop, A.R.; Cai, D.

    1997-04-01

    We present a preliminary summary of the zero temperature properties of the two-dimensional random sine-Gordon model of surface growth on disordered substrates. We found that the properties of this model can be accurately computed by using lattices of moderate size as the behavior of the model turns out to be independent of the size above certain length ({approx} 128 x 128 lattices). Subsequently, we show that the behavior of the height difference correlation function is of (log r){sup 2} type up to a certain correlation length ({xi} {approx} 20), which rules out predictions of log r behavior for all temperatures obtained by replica-variational techniques. Our results open the way to a better understanding of the complex landscape presented by this system, which has been the subject of very many (contradictory) analysis.

  19. Emergence of compact structures in a Klein-Gordon model.

    PubMed

    Rosenau, Philip; Kashdan, Eugene

    2010-01-22

    The Klein-Gordon model (KG) phi=P{'}(|phi|)phi/|phi| is Lorenz invariant and has a finite wave speed, yet its localized modes, whether Q balls or vortices, suffer from the same fundamental flaw as all other solitons-they extend indefinitely. Using the KG model as a case study, we demonstrate that appending the site potential, P{a}(phi|), with a subquadratic part P(|phi|)=b{2}|phi|{1+delta}+P{a}(|phi|), 0

  20. Gordon S. Fulcher: Renaissance Man of Glass Science

    NASA Astrophysics Data System (ADS)

    Mauro, John

    2014-11-01

    To a glass scientist, the name “Fulcher” conjures images of viscosity vs. temperature diagrams for glass-forming liquids. Indeed, Gordon Fulcher’s seminal 1925 publication, in which he proposed his three-parameter model of viscosity, is one of the most significant and influential papers ever published in the field of glass science. Fulcher developed this equation during the early part of his 14-year career at Corning Glass Works (1920-1934). However, Fulcher’s work in viscosity represents a small fraction of his highly diverse and accomplished career, which included pioneering the field of electrocast ceramics and developing the modern system of scientific abstracting that it still in use today. Fulcher also had a keen interest in social and economic problems, and his latter research focused heavily on the field of metacognition, i.e., the process of thinking.

  1. 2011 Plant Lipids: Structure, Metabolism, & Function Gordon Research Conference

    SciTech Connect

    Christopher Benning

    2011-02-04

    This is the second Gordon Research Conference on 'Plant Lipids: Structure, Metabolism & Function'. It covers current topics in lipid structure, metabolism and function in eukaryotic photosynthetic organisms including seed plants, algae, mosses and ferns. Work in photosynthetic bacteria is considered as well as it serves the understanding of specific aspects of lipid metabolism in plants. Breakthroughs are discussed in research on plant lipids as diverse as glycerolipids, sphingolipids, lipids of the cell surface, isoprenoids, fatty acids and their derivatives. The program covers nine concepts at the forefront of research under which afore mentioned plant lipid classes are discussed. The goal is to integrate areas such as lipid signaling, basic lipid metabolism, membrane function, lipid analysis, and lipid engineering to achieve a high level of stimulating interaction among diverse researchers with interests in plant lipids. One Emphasis is on the dynamics and regulation of lipid metabolism during plant cell development and in response to environmental factors.

  2. A higher plant mitochondrial homologue of the yeast m-AAA protease. Molecular cloning, localization, and putative function.

    PubMed

    Kolodziejczak, Marta; Kolaczkowska, Anna; Szczesny, Bartosz; Urantowka, Adam; Knorpp, Carina; Kieleczawa, Jan; Janska, Hanna

    2002-11-15

    Mitochondrial AAA metalloproteases play a fundamental role in mitochondrial biogenesis and function. They have been identified in yeast and animals but not yet in plants. This work describes the isolation and sequence analysis of the full-length cDNA from the pea (Pisum sativum) with significant homology to the yeast matrix AAA (m-AAA) protease. The product of this clone was imported into isolated pea mitochondria where it was processed to its mature form (PsFtsH). We have shown that the central region of PsFtsH containing the chaperone domain is exposed to the matrix space. Furthermore, we have demonstrated that the pea protease can complement respiration deficiency in the yta10 and/or yta12 null yeast mutants, indicating that the plant protein can compensate for the loss of at least some of the important m-AAA functions in yeast. Based on biochemical experiments using isolated pea mitochondria, we propose that PsFtsH-like m-AAA is involved in the accumulation of the subunit 9 of the ATP synthase in the mitochondrial membrane.

  3. Astronaut Gordon Cooper in his spacecraft during pre-flight checks

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut L. Gordon Cooper Jr.,prime pilot for the Mercury-Atlas 9 mission, inside his Mercury spacecraft runs through one of the numerous pre-flight checks surrounded by dials, switches, indicators and buttons.

  4. Sine-Gordon solitons in networks: Scattering and transmission at vertices

    NASA Astrophysics Data System (ADS)

    Sobirov, Zarif; Babajanov, Doniyor; Matrasulov, Davron; Nakamura, Katsuhiro; Uecker, Hannes

    2016-09-01

    We consider the sine-Gordon equation on metric graphs with simple topologies and derive vertex boundary conditions from the fundamental conservation laws together with successive space-derivatives of sine-Gordon equation. We analytically obtain traveling-wave solutions in the form of standard sine-Gordon solitons such as kinks and antikinks for star and tree graphs. We show that for this case the sine-Gordon equation becomes completely integrable just as in case of a simple 1D chain. This simple analysis provides a cornerstone for the numerical solution of the general case, including a quantification of the vertex scattering. Applications of the obtained results to Josephson junction networks and DNA double helix are discussed.

  5. Spacetimes with a separable Klein-Gordon equation in higher dimensions

    NASA Astrophysics Data System (ADS)

    Kolář, Ivan; Krtouš, Pavel

    2016-01-01

    We study spacetimes that lead to a separable Klein-Gordon equation in a general number of dimensions. We introduce an ansatz for the metric in higher dimensions motivated by analogical work by Carter in four dimensions and find solutions of the Klein-Gordon equation. For such a metric we solve the Einstein equations and regain the Kerr-NUT-(A)dS spacetime as one of our results. Other solutions lead to the Einstein-Kähler metric of a Euclidean signature. Next we investigate a warped geometry of two Klein-Gordon separable spaces with a properly chosen warped factor. We show that the resulting metric leads also to a separable Klein-Gordon equation and we find the corresponding solutions. Finally, we solve the Einstein equations for the warped geometry and obtain new solutions.

  6. TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

    PubMed Central

    Ye, Qiaozhen; Rosenberg, Scott C; Moeller, Arne; Speir, Jeffrey A; Su, Tiffany Y; Corbett, Kevin D

    2015-01-01

    The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family. Here we present the structure of the Caenorhabditis elegans TRIP13 ortholog PCH-2, revealing a new family of AAA+ ATPase protein remodelers. PCH-2 possesses a substrate-recognition domain related to those of the protein remodelers NSF and p97, while its overall hexameric architecture and likely structural mechanism bear close similarities to the bacterial protein unfoldase ClpX. We find that TRIP13, aided by the adapter protein p31(comet), converts the HORMA-family spindle checkpoint protein MAD2 from a signaling-active ‘closed’ conformer to an inactive ‘open’ conformer. We propose that TRIP13 and p31(comet) collaborate to inactivate the spindle assembly checkpoint through MAD2 conformational conversion and disassembly of mitotic checkpoint complexes. A parallel HORMA protein disassembly activity likely underlies TRIP13's critical regulatory functions in meiotic chromosome structure and recombination. DOI: http://dx.doi.org/10.7554/eLife.07367.001 PMID:25918846

  7. Going the distance: validation of Acuros and AAA at an extended SSD of 400 cm.

    PubMed

    Lamichhane, Narottam; Patel, Vivek N; Studenski, Matthew T

    2016-01-01

    Accurate dose calculation and treatment delivery is essential for total body irradiation (TBI). In an effort to verify the accuracy of TBI dose calculation at our institution, we evaluated both the Varian Eclipse AAA and Acuros algorithms to predict dose distributions at an extended source-to-surface distance (SSD) of 400 cm. Measurements were compared to calculated values for a 6 MV beam in physical and virtual phantoms at 400 cm SSD using open beams for both 5 × 5 and 40 × 40cm2 field sizes. Inline and crossline profiles were acquired at equivalent depths of 5 cm, 10 cm, and 20 cm. Depth-dose curves were acquired using EBT2 film and an ion chamber for both field sizes. Finally, a RANDO phantom was used to simulate an actual TBI treatment. At this extended SSD, care must be taken using the planning system as there is good relative agreement between measured and calculated profiles for both algorithms, but there are deviations in terms of the absolute dose. Acuros has better agreement than AAA in the penumbra region. PMID:27074473

  8. Changes in the wall shear stresses (WSS) during the enlargement of Abdominal Aortic Aneurysms (AAA)

    NASA Astrophysics Data System (ADS)

    Salsac, Anne-Virginie; Sparks, Steven R.; Chomaz, Jean-Marc; Lasheras, Juan C.

    2004-11-01

    The changes in the evolution of the spatial and temporal distribution of the WSS and gradients of WSS at different stages of the enlargement of AAAs are important to understand the etiology and progression of this vascular disease, since they affect the wall structural integrity, primarily via the changes induced on the shape, functions and metabolism of the endothelial cells. PIV measurements were performed in aneurysm models, while changing systematically their geometric parameters. We show that, even at very early stages of the disease (dilatation > 30%), the flow separates from the wall and the formation of a large vortex ring followed by internal shear layers leads to the generation of WSS that drastically differ from the healthy vessel. Inside the AAA, the mean WSS decreases to zero and the magnitude of the WSS can be as low as 26% of the value in a healthy vessel. Two regions with distinct patterns of WSS were identified. The region of flow detachment, with oscillatory WSS of very low mean, and the region of flow reattachment, located distally, where large, negative WSS and sustained gradients of WSS are produced as a result of the impact of the vortex ring on the wall.

  9. Structural Characterization of the ATPase Reaction Cycle of Endosomal AAA Protein Vps4

    SciTech Connect

    Xiao, Junyu; Xia, Hengchuan; Yoshino-Koh, Kae; Zhou, Jiahai; Xu, Zhaohui

    2008-12-12

    The multivesicular body (MVB) pathway functions in multiple cellular processes including cell surface receptor down-regulation and viral budding from host cells. An important step in the MVB pathway is the correct sorting of cargo molecules, which requires the assembly and disassembly of endosomal sorting complexes required for transport (ESCRTs) on the endosomal membrane. Disassembly of the ESCRTs is catalyzed by ATPase associated with various cellular activities (AAA) protein Vps4. Vps4 contains a single AAA domain and undergoes ATP-dependent quaternary structural change to disassemble the ESCRTs. Structural and biochemical analyses of the Vps4 ATPase reaction cycle are reported here. Crystal structures of Saccharomyces cerevisiae Vps4 in both the nucleotide-free form and the ADP-bound form provide the first structural view illustrating how nucleotide binding might induce conformational changes within Vps4 that lead to oligomerization and binding to its substrate ESCRT-III subunits. In contrast to previous models, characterization of the Vps4 structure now supports a model where the ground state of Vps4 in the ATPase reaction cycle is predominantly a monomer and the activated state is a dodecamer. Comparison with a previously reported human VPS4B structure suggests that Vps4 functions in the MVB pathway via a highly conserved mechanism supported by similar protein-protein interactions during its ATPase reaction cycle.

  10. An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome

    PubMed Central

    Förster, Friedrich; Lasker, Keren; Beck, Florian; Nickell, Stephan; Sali, Andrej; Baumeister, Wolfgang

    2009-01-01

    The 26S proteasome is the most downstream element of the ubiquitin-proteasome pathway of protein degradation. It is composed of the 20S core particle (CP) and the 19S regulatory particle (RP). The RP consists of 6 AAA-ATPases and at least 13 non-ATPase subunits. Based on a cryo-EM map of the 26S proteasome, structures of homologs, and physical protein-protein interactions we derive an atomic model of the AAA-ATPase-CP sub-complex. The ATPase order in our model (Rpt1/Rpt2/Rpt6/Rpt3/Rpt4/Rpt5) is in excellent agreement with the recently identified base-precursor complexes formed during the assembly of the RP. Furthermore, the atomic CP-AAA-ATPase model suggests that the assembly chaperone Nas6 facilitates CP-RP association by enhancing the shape complementarity between Rpt3 and its binding CP alpha subunits partners. PMID:19653995

  11. An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome.

    PubMed

    Förster, Friedrich; Lasker, Keren; Beck, Florian; Nickell, Stephan; Sali, Andrej; Baumeister, Wolfgang

    2009-10-16

    The 26S proteasome is the most downstream element of the ubiquitin-proteasome pathway of protein degradation. It is composed of the 20S core particle (CP) and the 19S regulatory particle (RP). The RP consists of 6 AAA-ATPases and at least 13 non-ATPase subunits. Based on a cryo-EM map of the 26S proteasome, structures of homologs, and physical protein-protein interactions we derive an atomic model of the AAA-ATPase-CP sub-complex. The ATPase order in our model (Rpt1/Rpt2/Rpt6/Rpt3/Rpt4/Rpt5) is in excellent agreement with the recently identified base-precursor complexes formed during the assembly of the RP. Furthermore, the atomic CP-AAA-ATPase model suggests that the assembly chaperone Nas6 facilitates CP-RP association by enhancing the shape complementarity between Rpt3 and its binding CP alpha subunits partners.

  12. The ATPase of the phi29 DNA packaging motor is a member of the hexameric AAA+ superfamily.

    PubMed

    Schwartz, Chad; De Donatis, Gian Marco; Fang, Huaming; Guo, Peixuan

    2013-08-15

    The AAA+ superfamily of proteins is a class of motor ATPases performing a wide range of functions that typically exist as hexamers. The ATPase of phi29 DNA packaging motor has long been a subject of debate in terms of stoichiometry and mechanism of action. Here, we confirmed the stoichiometry of phi29 motor ATPase to be a hexamer and provide data suggesting that the phi29 motor ATPase is a member of the classical hexameric AAA+ superfamily. Native PAGE, EMSA, capillary electrophoresis, ATP titration, and binomial distribution assay show that the ATPase is a hexamer. Mutations in the known Walker motifs of the ATPase validated our previous assumptions that the protein exists as another member of this AAA+ superfamily. Our data also supports the finding that the phi29 DNA packaging motor uses a revolution mechanism without rotation or coiling (Schwartz et al., this issue).

  13. Effects of the Transient Blood Flow-Wall Interaction on the Wall Stress Distribution in Abdominal Aortic Aneurysm (AAA)

    NASA Astrophysics Data System (ADS)

    Tang, Rubing; Geindreau, Christian; Lasheras, Juan

    2006-11-01

    Our static finite element analysis (FEA) of both idealized and real clinical models has shown that the maximum diameter and asymmetry have substantial influence on the AAA wall stress distribution. The thrombus inside the AAA was also found to reduce the magnitude of the wall stresses. To achieve a better understanding of the wall stress distribution in real AAAs, a dynamic FEA was also performed. We considered models, both symmetric and non-symmetric, in which the aorta is assumed isotropic with nonlinear material properties. For the limiting case of rigid walls, the evolution of the flow pattern and the wall shear stresses due to fluid flow at different stages of cardiac cycle predicted by our simulations are compared with experimental results obtained in in-vitro models. A good agreement is found between both results. Finally, we have extended the analysis to the physiologically correct case of deformable walls and characterized the transient effects on the wall stresses.

  14. Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state

    NASA Astrophysics Data System (ADS)

    Morito, Daisuke; Nishikawa, Kouki; Hoseki, Jun; Kitamura, Akira; Kotani, Yuri; Kiso, Kazumi; Kinjo, Masataka; Fujiyoshi, Yoshinori; Nagata, Kazuhiro

    2014-03-01

    Moyamoya disease is an idiopathic human cerebrovascular disorder that is characterized by progressive stenosis and abnormal collateral vessels. We recently identified mysterin/RNF213 as its first susceptibility gene, which encodes a 591-kDa protein containing enzymatically active P-loop ATPase and ubiquitin ligase domains and is involved in proper vascular development in zebrafish. Here we demonstrate that mysterin further contains two tandem AAA+ ATPase modules and forms huge ring-shaped oligomeric complex. AAA+ ATPases are known to generally mediate various biophysical and mechanical processes with the characteristic ring-shaped structure. Fluorescence correlation spectroscopy and biochemical evaluation suggested that mysterin dynamically changes its oligomeric forms through ATP/ADP binding and hydrolysis cycles. Thus, the moyamoya disease-associated gene product is a unique protein that functions as ubiquitin ligase and AAA+ ATPase, which possibly contributes to vascular development through mechanical processes in the cell.

  15. An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome

    SciTech Connect

    Foerster, Friedrich; Lasker, Keren; Beck, Florian; Nickell, Stephan; Sali, Andrej; Baumeister, Wolfgang

    2009-10-16

    The 26S proteasome is the most downstream element of the ubiquitin-proteasome pathway of protein degradation. It is composed of the 20S core particle (CP) and the 19S regulatory particle (RP). The RP consists of 6 AAA-ATPases and at least 13 non-ATPase subunits. Based on a cryo-EM map of the 26S proteasome, structures of homologs, and physical protein-protein interactions we derive an atomic model of the AAA-ATPase-CP sub-complex. The ATPase order in our model (Rpt1/Rpt2/Rpt6/Rpt3/Rpt4/Rpt5) is in excellent agreement with the recently identified base-precursor complexes formed during the assembly of the RP. Furthermore, the atomic CP-AAA-ATPase model suggests that the assembly chaperone Nas6 facilitates CP-RP association by enhancing the shape complementarity between Rpt3 and its binding CP alpha subunits partners.

  16. SecAAA trimer is fully functional as SecAA dimer in the membrane: Existence of higher oligomers?

    PubMed Central

    Wang, Hongyun; Ma, Yamin; Hsieh, Ying-Hsin; Yang, Hsiuchin; Li, Minyong; Wang, Binghe; Tai, Phang C.

    2014-01-01

    SecA is an essential ATPase in bacterial Sec-dependent protein translocation pathway, and equilibrates between monomers and dimers in solution. The question of whether SecA functions as monomers or dimers in membranes during the protein translocation is controversial. We previously constructed a tail-to-head SecAA tandem dimer, and showed it is fully functional by complementation in vivo and protein translocation in vitro, indicating that SecA can function at least as a dimer in the membrane without dissociating into monomers. In this study, we further constructed genetically a tail-to-head SecAAA trimer, which is functional in complementing a temperature-sensitive secA mutant. The purified SecAAA trimer per protomer is fully active as SecAA tandem dimers in ATPase activity, in protein translocation in vitro and in ion channel activities in the oocytes. With these functional tail-to-head trimer SecAAA and tandem SecAA, we examined their surface topology in the presence of liposomes using AFM. As expected, the soluble SecAAA without lipids are larger than SecAA. However, the ring/pore structures of SecAAA trimers were, surprisingly, almost identical to the SecA 2-monomers and SecAA dimers, raising the intriguing possibility that the SecA may exist and function as hexamer ring-structures in membranes. Cross-linking with formaldehyde showed that SecA, SecAA and SecAAA could form larger oligomers, including the hexamers. The molecular modeling simulation shows that both tail-to-head and tail-to-tail hexamers in the membranes are possible. PMID:24704204

  17. Walker-A threonine couples nucleotide occupancy with the chaperone activity of the AAA+ ATPase ClpB

    PubMed Central

    Nagy, Maria; Wu, Hui-Chuan; Liu, Zhonghua; Kedzierska-Mieszkowska, Sabina; Zolkiewski, Michal

    2009-01-01

    Hexameric AAA+ ATPases induce conformational changes in a variety of macromolecules. AAA+ structures contain the nucleotide-binding P-loop with the Walker A sequence motif: GxxGxGK(T/S). A subfamily of AAA+ sequences contains Asn in the Walker A motif instead of Thr or Ser. This noncanonical subfamily includes torsinA, an ER protein linked to human dystonia and DnaC, a bacterial helicase loader. Role of the noncanonical Walker A motif in the functionality of AAA+ ATPases has not been explored yet. To determine functional effects of introduction of Asn into the Walker A sequence, we replaced the Walker-A Thr with Asn in ClpB, a bacterial AAA+ chaperone which reactivates aggregated proteins. We found that the T-to-N mutation in Walker A partially inhibited the ATPase activity of ClpB, but did not affect the ClpB capability to associate into hexamers. Interestingly, the noncanonical Walker A sequence in ClpB induced preferential binding of ADP vs. ATP and uncoupled the linkage between the ATP-bound conformation and the high-affinity binding to protein aggregates. As a consequence, ClpB with the noncanonical Walker A sequence showed a low chaperone activity in vitro and in vivo. Our results demonstrate a novel role of the Walker-A Thr in sensing the nucleotide's γ-phosphate and in maintaining an allosteric linkage between the P-loop and the aggregate binding site of ClpB. We postulate that AAA+ ATPases with the noncanonical Walker A might utilize distinct mechanisms to couple the ATPase cycle with their substrate-remodeling activity. PMID:19177562

  18. Industrial Arts: "Youth's Gateway to the Future." Addresses and Proceedings of the 40th National and 7th International Conference of the American Industrial Arts Association (Atlanta, Georgia, February 27-March 3, 1978).

    ERIC Educational Resources Information Center

    Northern Kentucky Univ., Highland Heights.

    Included in this document are the addresses and proceedings of the 40th National and 7th International Annual Conference of the American Industrial Arts Association. The proceedings are organized by the following subject groups: career education, curriculum, drafting, electricity/electronics, elementary school industrial arts, energy, evaluation,…

  19. 2010 Thin Film & Small Scale Mechanical Behavior Gordon Research Conference

    SciTech Connect

    Dr. Thomas Balk

    2010-07-30

    Over the past decades, it has been well established that the mechanical behavior of materials changes when they are confined geometrically at least in one dimension to small scale. It is the aim of the 2010 Gordon Conference on 'Thin Film and Small Scale Mechanical Behavior' to discuss cutting-edge research on elastic, plastic and time-dependent deformation as well as degradation mechanisms like fracture, fatigue and wear at small scales. As in the past, the conference will benefit from contributions from fundamental studies of physical mechanisms linked to material science and engineering reaching towards application in modern applications ranging from optical and microelectronic devices and nano- or micro-electrical mechanical systems to devices for energy production and storage. The conference will feature entirely new testing methodologies and in situ measurements as well as recent progress in atomistic and micromechanical modeling. Particularly, emerging topics in the area of energy conversion and storage, such as material for batteries will be highlighted. The study of small-scale mechanical phenomena in systems related to energy production, conversion or storage offer an enticing opportunity to materials scientists, who can provide new insight and investigate these phenomena with methods that have not previously been exploited.

  20. 2010 Ceramics, Solid State Studies in Gordon Research Conference

    SciTech Connect

    John Halloran

    2010-08-20

    The 2010 Gordon Conference on Solid State Studies in Ceramics will present forefront research on ceramic materials in energy conversion, storage, and environmental sustainability. Oxide materials in advanced Li-ion batteries will be featured, including first principles computational methods, new experimental methods, novel synthesis, and the design of batteries that exploit nanoscale cathode materials. Several speakers address advances in oxides for solar applications, including photo-catalysts for solar hydrogen production and dye sensitized solar cells, along with thin film photovoltaics. Fast ionic conducting ceramics in electrochemical energy conversion and storage will be addressed for fuel cells and electrochemical storage. New concepts for electrochemical capacitor materials will be addressed, as will thermoelectric, geopolymers, and ceramics in nuclear energy. The Conference will bring together investigators at the forefront of their field as well as junior scientists in a collegial atmosphere, with programmed discussion sessions and informal gatherings in the afternoons and evenings. Poster presentations provide opportunities for junior scientists and graduate students to present their work and exchange ideas with leaders in the field. This Conference provides an avenue for scientists from different disciplines to explore new ideas and promotes cross-disciplinary collaborations in the various research areas represented.

  1. 2010 ELECTRODEPOSITION GORDON RESEARCH CONFERENCE, AUGUST 1-6, 2010

    SciTech Connect

    Peter Searson

    2010-08-06

    The 2010 Gordon Conference on Electrodeposition will present cutting-edge research on electrodeposition with emphasis on (i) advances in basic science, (ii) developments in next-generation technologies, and (iii) new and emerging areas. The Conference will feature a wide range of topics, from atomic scale processes, nucleation and growth, thin film deposition, and electrocrystallization, to applications of electrodeposition in devices including microelectronics, solar energy, and power sources. The Conference will bring together investigators from a wide range of scientific disciplines, including chemical engineering, materials science and engineering, physics, and chemistry. The Conference will feature invited speakers at the forefront of the field, and a late-breaking news session that will provide the opportunity for graduate students, post-docs, and junior faculty to participate. The collegial atmosphere of this Conference, with scientific talks and poster sessions, as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to discuss current issues and promotes cross-disciplinary collaborations in the various research areas represented. The Conference will be held at Colby-Sawyer College, located in the Mt. Kearsarge-Lake Sunapee Region of New Hampshire. The surrounding mountains, forests, and lakes provide a beautiful setting for this conference. The attendance is limited so early application is strongly advised.

  2. 1998 Gordon Research Conference on Gravitational Effects on Living Systems

    NASA Technical Reports Server (NTRS)

    Evans, Michael L.

    1998-01-01

    The Gordon Research Conference (GRC) on GRAVITATIONAL EFFECTS ON LIVING SYSTEMS was held at COLBY SAYWER 2 from 7/12/98 thru 7/17/98. The Conference was well-attended with 94 participants. The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. A copy of the formal schedule and speaker program and the poster program is included. In addition to these formal interactions, "free time" was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field.

  3. 2012 MUTAGENESIS GORDON RESEARCH CONFERENCE, AUGUST 19-23, 2012

    SciTech Connect

    Demple, Bruce

    2012-08-23

    The delicate balance among cellular pathways that control mutagenic changes in DNA will be the focus of the 2012 Mutagenesis Gordon Research Conference. Mutagenesis is essential for evolution, while genetic stability maintains cellular functions in all organisms from microbes to metazoans. Different systems handle DNA lesions at various times of the cell cycle and in different places within the nucleus, and inappropriate actions can lead to mutations. While mutation in humans is closely linked to disease, notably cancers, mutational systems can also be beneficial. The conference will highlight topics of beneficial mutagenesis, including full establishment of the immune system, cell survival mechanisms, and evolution and adaptation in microbial systems. Equal prominence will be given to detrimental mutation processes, especially those involved in driving cancer, neurological diseases, premature aging, and other threats to human health. Provisional session titles include Branching Pathways in Mutagenesis; Oxidative Stress and Endogenous DNA Damage; DNA Maintenance Pathways; Recombination, Good and Bad; Problematic DNA Structures; Localized Mutagenesis; Hypermutation in the Microbial World; and Mutation and Disease.

  4. Lytic Water Dynamics Reveal Evolutionarily Conserved Mechanisms of ATP Hydrolysis by TIP49 AAA+ ATPases

    PubMed Central

    Afanasyeva, Arina; Hirtreiter, Angela; Schreiber, Anne; Grohmann, Dina; Pobegalov, Georgii; McKay, Adam R.; Tsaneva, Irina; Petukhov, Michael; Käs, Emmanuel; Grigoriev, Mikhail; Werner, Finn

    2014-01-01

    Summary Eukaryotic TIP49a (Pontin) and TIP49b (Reptin) AAA+ ATPases play essential roles in key cellular processes. How their weak ATPase activity contributes to their important functions remains largely unknown and difficult to analyze because of the divergent properties of TIP49a and TIP49b proteins and of their homo- and hetero-oligomeric assemblies. To circumvent these complexities, we have analyzed the single ancient TIP49 ortholog found in the archaeon Methanopyrus kandleri (mkTIP49). All-atom homology modeling and molecular dynamics simulations validated by biochemical assays reveal highly conserved organizational principles and identify key residues for ATP hydrolysis. An unanticipated crosstalk between Walker B and Sensor I motifs impacts the dynamics of water molecules and highlights a critical role of trans-acting aspartates in the lytic water activation step that is essential for the associative mechanism of ATP hydrolysis. PMID:24613487

  5. Distinct quaternary structures of the AAA+ Lon protease control substrate degradation.

    PubMed

    Vieux, Ellen F; Wohlever, Matthew L; Chen, James Z; Sauer, Robert T; Baker, Tania A

    2013-05-28

    Lon is an ATPase associated with cellular activities (AAA+) protease that controls cell division in response to stress and also degrades misfolded and damaged proteins. Subunits of Lon are known to assemble into ring-shaped homohexamers that enclose an internal degradation chamber. Here, we demonstrate that hexamers of Escherichia coli Lon also interact to form a dodecamer at physiological protein concentrations. Electron microscopy of this dodecamer reveals a prolate structure with the protease chambers at the distal ends and a matrix of N domains forming an equatorial hexamer-hexamer interface, with portals of ∼45 Å providing access to the enzyme lumen. Compared with hexamers, Lon dodecamers are much less active in degrading large substrates but equally active in degrading small substrates. Our results support a unique gating mechanism that allows the repertoire of Lon substrates to be tuned by its assembly state.

  6. The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly

    SciTech Connect

    Her, Joonyoung; Chung, In Kwon

    2012-01-20

    Highlights: Black-Right-Pointing-Pointer Identification of the AAA-ATPase NVL2 as a novel hTERT-interacting protein. Black-Right-Pointing-Pointer NVL2 associates with catalytically active telomerase via an interaction with hTERT. Black-Right-Pointing-Pointer NVL2 is a telomerase component essential for holoenzyme assembly. Black-Right-Pointing-Pointer ATP-binding activity of NVL2 is required for hTERT binding and telomerase assembly. -- Abstract: Continued cell proliferation requires telomerase to maintain functional telomeres that are essential for chromosome integrity. Although the core enzyme includes a telomerase reverse transcriptase (TERT) and a telomerase RNA component (TERC), a number of auxiliary proteins have been identified to regulate telomerase assembly, localization, and enzymatic activity. Here we describe the characterization of the AAA-ATPase NVL2 as a novel hTERT-interacting protein. NVL2 interacts and co-localizes with hTERT in the nucleolus. NLV2 is also found in association with catalytically competent telomerase in cell lysates through an interaction with hTERT. Depletion of endogenous NVL2 by small interfering RNA led to a decrease in hTERT without affecting the steady-state levels of hTERT mRNA, thereby reducing telomerase activity, suggesting that NVL2 is an essential component of the telomerase holoenzyme. We also found that ATP-binding activity of NVL2 is required for hTERT binding as well as telomerase assembly. Our findings suggest that NVL2, in addition to its role in ribosome biosynthesis, is essential for telomerase biogenesis and provides an alternative approach for inhibiting telomerase activity in cancer.

  7. Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p.

    PubMed Central

    Babst, M; Sato, T K; Banta, L M; Emr, S D

    1997-01-01

    In a late-Golgi compartment of the yeast Saccharomyces cerevisiae, vacuolar proteins such as carboxypeptidase Y (CPY) are actively sorted away from the secretory pathway and transported to the vacuole via a pre-vacuolar, endosome-like intermediate. The vacuolar protein sorting (vps) mutant vps4 accumulates vacuolar, endocytic and late-Golgi markers in an aberrant multilamellar pre-vacuolar compartment. The VPS4 gene has been cloned and found to encode a 48 kDa protein which belongs to the protein family of AAA-type ATPases. The Vps4 protein was purified and shown to exhibit an N-ethylmaleimide-sensitive ATPase activity. A single amino acid change within the AAA motif of Vps4p yielded a protein that lacked ATPase activity and did not complement the protein sorting or morphological defects of the vps4 delta1 mutant. Indeed, when expressed at normal levels in wild-type cells, the mutant vps4 gene acted as a dominant-negative allele. The phenotypic characterization of a temperature-sensitive vps4 allele showed that the immediate consequence of loss of Vps4p function is a defect in vacuolar protein delivery. In this mutant, precursor CPY was not secreted but instead accumulated in an intracellular compartment, presumably the pre-vacuolar endosome. Electron microscopy revealed that upon temperature shift, exaggerated stacks of curved cisternal membranes (aberrant endosome) also accumulated in the vps4ts mutant. Based on these and other observations, we propose that Vps4p function is required for efficient transport out of the pre-vacuolar endosome. PMID:9155008

  8. Student-Athlete Perceptions of a Summer Pre-Enrollment Experience at an NCAA Division I-AAA Institution

    ERIC Educational Resources Information Center

    Dalgety, Michael Franklin

    2012-01-01

    The purpose of this exploratory qualitative study was to examine student-athlete perceptions of the role of summer pre-enrollment in their adjustment and transition to college. The study focused on student-athletes who received athletically-related financial aid at a National Collegiate Athletic Association (NCAA) Division I-AAA institution. The…

  9. Pareto front analysis of 6 and 15 MV dynamic IMRT for lung cancer using pencil beam, AAA and Monte Carlo

    NASA Astrophysics Data System (ADS)

    Ottosson, R. O.; Karlsson, A.; Behrens, C. F.

    2010-08-01

    The pencil beam dose calculation method is frequently used in modern radiation therapy treatment planning regardless of the fact that it is documented inaccurately for cases involving large density variations. The inaccuracies are larger for higher beam energies. As a result, low energy beams are conventionally used for lung treatments. The aim of this study was to analyze the advantages and disadvantages of dynamic IMRT treatment planning for high and low photon energy in order to assess if deviating from the conventional low energy approach could be favorable in some cases. Furthermore, the influence of motion on the dose distribution was investigated. Four non-small cell lung cancer cases were selected for this study. Inverse planning was conducted using Varian Eclipse. A total number of 31 dynamic IMRT plans, distributed amongst the four cases, were created ranging from PTV conformity weighted to normal tissue sparing weighted. All optimized treatment plans were calculated using three different calculation algorithms (PBC, AAA and MC). In order to study the influence of motion, two virtual lung phantoms were created. The idea was to mimic two different situations: one where the GTV is located centrally in the PTV and another where the GTV was close to the edge of the PTV. PBC is in poor agreement with MC and AAA for all cases and treatment plans. AAA overestimates the dose, compared to MC. This effect is more pronounced for 15 than 6 MV. AAA and MC both predict similar perturbations in dose distributions when moving the GTV to the edge of the PTV. PBC, however, predicts results contradicting those of AAA and MC. This study shows that PB-based dose calculation algorithms are clinically insufficient for patient geometries involving large density inhomogeneities. AAA is in much better agreement with MC, but even a small overestimation of the dose level by the algorithm might lead to a large part of the PTV being underdosed. It is advisable to use low energy as a

  10. Pareto front analysis of 6 and 15 MV dynamic IMRT for lung cancer using pencil beam, AAA and Monte Carlo.

    PubMed

    Ottosson, R O; Karlsson, A; Behrens, C F

    2010-08-21

    The pencil beam dose calculation method is frequently used in modern radiation therapy treatment planning regardless of the fact that it is documented inaccurately for cases involving large density variations. The inaccuracies are larger for higher beam energies. As a result, low energy beams are conventionally used for lung treatments. The aim of this study was to analyze the advantages and disadvantages of dynamic IMRT treatment planning for high and low photon energy in order to assess if deviating from the conventional low energy approach could be favorable in some cases. Furthermore, the influence of motion on the dose distribution was investigated. Four non-small cell lung cancer cases were selected for this study. Inverse planning was conducted using Varian Eclipse. A total number of 31 dynamic IMRT plans, distributed amongst the four cases, were created ranging from PTV conformity weighted to normal tissue sparing weighted. All optimized treatment plans were calculated using three different calculation algorithms (PBC, AAA and MC). In order to study the influence of motion, two virtual lung phantoms were created. The idea was to mimic two different situations: one where the GTV is located centrally in the PTV and another where the GTV was close to the edge of the PTV. PBC is in poor agreement with MC and AAA for all cases and treatment plans. AAA overestimates the dose, compared to MC. This effect is more pronounced for 15 than 6 MV. AAA and MC both predict similar perturbations in dose distributions when moving the GTV to the edge of the PTV. PBC, however, predicts results contradicting those of AAA and MC. This study shows that PB-based dose calculation algorithms are clinically insufficient for patient geometries involving large density inhomogeneities. AAA is in much better agreement with MC, but even a small overestimation of the dose level by the algorithm might lead to a large part of the PTV being underdosed. It is advisable to use low energy as a

  11. Bernard de Gordon (fl. 1270-1330): medieval physician and teacher.

    PubMed

    Pearn, John

    2013-02-01

    The Montpellier physician Bernard de Gordon flourished in the late Middle Ages in the era when university education first evolved in the training of European physicians. Fragmentary details of his life and medical influence are known from seven books, particularly his extensive (163 chapters) text Lilium Medicine and from Chaucer's reference to him in the Canterbury Tales. Chaucer lists Bernard de Gordon as one whose writings were part of the core curriculum of the best-trained European doctors of medieval Europe. Bernard de Gordon was one of that small group of medieval physicians who reverently followed Galenic lore which had endured for a thousand years yet who began to challenge its details and to experiment clinically with new methods of treatment. In his writings, Bernard de Gordon made the first reference to spectacles and to the hernial truss. His writings also contained detailed desiderata for the ethical best practice of medicine of his day, extending the principles of both Hippocrates and Haly ibn Abbas. Unlike many of the surviving writings of other medieval medical teachers, his texts have within them a tone of humility and acknowledged fallibility. Bernard de Gordon holds a small but significant place in the evolving pre-Renaissance chronology of medical professionalism.

  12. Bernard de Gordon (fl. 1270-1330): medieval physician and teacher.

    PubMed

    Pearn, John

    2013-02-01

    The Montpellier physician Bernard de Gordon flourished in the late Middle Ages in the era when university education first evolved in the training of European physicians. Fragmentary details of his life and medical influence are known from seven books, particularly his extensive (163 chapters) text Lilium Medicine and from Chaucer's reference to him in the Canterbury Tales. Chaucer lists Bernard de Gordon as one whose writings were part of the core curriculum of the best-trained European doctors of medieval Europe. Bernard de Gordon was one of that small group of medieval physicians who reverently followed Galenic lore which had endured for a thousand years yet who began to challenge its details and to experiment clinically with new methods of treatment. In his writings, Bernard de Gordon made the first reference to spectacles and to the hernial truss. His writings also contained detailed desiderata for the ethical best practice of medicine of his day, extending the principles of both Hippocrates and Haly ibn Abbas. Unlike many of the surviving writings of other medieval medical teachers, his texts have within them a tone of humility and acknowledged fallibility. Bernard de Gordon holds a small but significant place in the evolving pre-Renaissance chronology of medical professionalism. PMID:23610222

  13. Symmetry analysis of the Klein-Gordon equation in Bianchi I spacetimes

    NASA Astrophysics Data System (ADS)

    Paliathanasis, A.; Tsamparlis, M.; Mustafa, M. T.

    2015-02-01

    In this work we perform the symmetry classification of the Klein-Gordon equation in Bianchi I spacetime. We apply a geometric method which relates the Lie symmetries of the Klein-Gordon equation with the conformal algebra of the underlying geometry. Furthermore, we prove that the Lie symmetries which follow from the conformal algebra are also Noether symmetries for the Klein-Gordon equation. We use these results in order to determine all the potentials in which the Klein-Gordon admits Lie and Noether symmetries. Due to the large number of cases and for easy reference the results are presented in the form of tables. For some of the potentials we use the Lie admitted symmetries to determine the corresponding invariant solution of the Klein-Gordon equation. Finally, we show that the results also solve the problem of classification of Lie/Noether point symmetries of the wave equation in Bianchi I spacetime and can be used for the determination of invariant solutions of the wave equation.

  14. 2010 Tetrapyrroles, Chemistry & Biology of Gordon Research Conference

    SciTech Connect

    Angela Wilks

    2010-07-30

    The objective of the Chemistry & Biology of Tetrapyrroles Gordon Conference is to bring together researchers from diverse disciplines that otherwise would not interact. By bringing biologists, chemists, engineers and clinicians with a common interest in tetrapyrroles the conference provides a forum for cross-disciplinary ideas and collaboration. The perspective provided by biologists, chemists, and clinicians working in fields such as newly discovered defects in human porphyrin metabolism, the myriad of strategies for light harvesting in photosynthetic organisms, novel tetrapyrroles that serve as auxiliary chromophores or enzyme cofactors, synthetic strategies in the design of novel tetrapyrrole scaffolds, and tetrapyrrole based cell signaling and regulatory systems, makes this conference unique in the field. Over the years the growing evidence for the role of tetrapyrroles and their reactive intermediates in cell signaling and regulation has been of increasing importance at this conference. The 2010 conference on Chemistry & Biology of Tetrapyrroles will focus on many of these new frontiers as outlined in the preliminary program listed. Speakers will emphasize unpublished results and new findings in the field. The oral sessions will be followed by the highly interactive afternoon poster sessions. The poster sessions provide all conferees with the opportunity to present their latest research and to exchange ideas in a more informal setting. As in the past, this opportunity will continue during the nightly social gathering that takes place in the poster hall following the evening lectures. All conferees are encouraged to submit and present posters. At the conference the best poster in the areas of biology, chemistry and medicine will be selected by a panel of previous conference chairs.

  15. RADIATION CHEMISTRY 2010 GORDON RESEARCH CONFERENCE JULY 18-23

    SciTech Connect

    Thomas Orlando

    2010-07-23

    The 2010 Gordon Conference on Radiation Chemistry will present cutting edge research regarding the study of radiation-induced chemical transformations. Radiation Chemistry or 'high energy' chemistry is primarily initiated by ionizing radiation: i.e. photons or particles with energy sufficient to create conduction band electrons and 'holes', excitons, ionic and neutral free radicals, highly excited states, and solvated electrons. These transients often interact or 'react' to form products vastly different than those produced under thermal equilibrium conditions. The non-equilibrium, non-thermal conditions driving radiation chemistry exist in plasmas, star-forming regions, the outer solar system, nuclear reactors, nuclear waste repositories, radiation-based medical/clinical treatment centers and in radiation/materials processing facilities. The 2010 conference has a strong interdisciplinary flavor with focus areas spanning (1) the fundamental physics and chemistry involved in ultrafast (atto/femtosecond) energy deposition events, (2) radiation-induced processes in biology (particularly spatially resolved studies), (3) radiation-induced modification of materials at the nanoscale and cosmic ray/x-ray mediated processes in planetary science/astrochemistry. While the conference concentrates on fundamental science, topical applied areas covered will also include nuclear power, materials/polymer processing, and clinical/radiation treatment in medicine. The Conference will bring together investigators at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present work in poster format or as contributors to the Young Investigator session. The program and format provides excellent avenues to promote cross-disciplinary collaborations.

  16. Happy 40th Cinema Guild

    ERIC Educational Resources Information Center

    Kuzyk, Raya

    2008-01-01

    On May 10, 1968, the Cannes Film Festival shuddered to a stop when filmmakers including Jean-Luc Godard and Francois Truffaut rushed the stage at the Palais des Festivals to protest French New Waver Henri Langlois's removal from his post as president of the National Cinematheque Francaise. Also that month, in that same spirit of film lovers'…

  17. Revisiting Gordon's Teacher Effectiveness Training: An Intervention Study on Teachers' Social and Emotional Learning

    ERIC Educational Resources Information Center

    Talvio, Markus; Lonka, Kirsti; Komulainen, Erkki; Kuusela, Marjo; Lintunen, Taru

    2013-01-01

    Introduction: This study explored the development of teachers' social and emotional learning (SEL) skills by using "Teacher Effectiveness Training (TET)" (Gordon Training International) as an intervention with two groups of teachers. Further Gordon's model was approached from the perspective of modern educational psychology.…

  18. 2012 CELLULAR & MOLECULAR FUNGAL BIOLOGY GORDON RESEARCH CONFERENCE, JUNE 17 - 22, 2012

    SciTech Connect

    Judith Berman

    2012-06-22

    The Gordon Research Conference on CELLULAR & MOLECULAR FUNGAL BIOLOGY was held at Holderness School, Holderness New Hampshire, June 17 - 22, 2012. The 2012 Gordon Conference on Cellular and Molecular Fungal Biology (CMFB) will present the latest, cutting-edge research on the exciting and growing field of molecular and cellular aspects of fungal biology. Topics will range from yeast to filamentous fungi, from model systems to economically important organisms, and from saprophytes and commensals to pathogens of plants and animals. The CMFB conference will feature a wide range of topics including systems biology, cell biology and morphogenesis, organismal interactions, genome organisation and regulation, pathogenesis, energy metabolism, biomass production and population genomics. The Conference was well-attended with 136 participants. Gordon Research Conferences does not permit publication of meeting proceedings.

  19. A revision of Trimuricea Gordon, 1926 (Cnidaria: Octocorallia: Plexauridae) with the description of six new species.

    PubMed

    Samimi-Namin, Kaveh; Ofwegen, Leen P Van

    2016-01-01

    The genus Trimuricea Gordon, 1926 is revised. An overview and identification key of all presently known Trimuricea species is given. The type material of Trimuricea africana Gordon, 1926, T. reticulata (Thomson & Simpson, 1909), T. merguiensis Gordon, 1926, T. inermis (Nutting, 1910), T. magna (Nutting, 1910) and T. caledonica Grasshoff, 1999, is re-examined. Trimuricea andamanensis (Thomson & Simpson, 1909) is assigned to Echinogorgia Kölliker, 1865, Trimuricea aff. reticulata (Samimi-Namin & van Ofwegen 2009a) is synonymised with T. persica n. sp.; and T. magna (Nutting, 1910) with T. inermis (Nutting, 1910). Furthermore, six new species are described and depicted, T. bicolor, T. flava, T. omanensis, T. persica, T. tuberculosa, and T. spinosa, increasing the number of known Trimuricea species to eleven. PMID:27394763

  20. The Klein-Gordon equation of a rotating charged hairy black hole in (2 + 1) dimensions

    NASA Astrophysics Data System (ADS)

    Pourhassan, B.

    2016-03-01

    In this paper, we consider the Klein-Gordon equation in a 3D charged rotating hairy black hole background to study behavior of a massive scalar field. In the general case, we find periodic-like behavior for the scalar field which may vanish at the black hole horizon or far from the black hole horizon. For the special cases of non-rotating or near horizon approximation, we find radial solution of Klein-Gordon equation in terms of hypergeometric and Kummer functions. Also for the case of uncharged black hole, we find numerical solution of the Klein-Gordon equation as periodic function which may enhance out of the black hole or vanish at horizon. We find allowed boundary conditions which may yield to the identical bosons described by scalar field.

  1. Relative importance of aneurysm diameter and body size for predicting AAA rupture in men and women

    PubMed Central

    Lo, Ruby C.; Lu, Bing; Fokkema, Margriet T.M.; Conrad, Mark; Patel, Virendra I.; Fillinger, Mark; Matyal, Robina; Schermerhorn, Marc L.

    2014-01-01

    Objectives Women have been shown to have up to a four-fold higher risk of abdominal aortic aneurysm (AAA) rupture at any given aneurysm diameter compared to men, leading to recommendations to offer repair to women at lower diameter thresholds. Although this higher risk of rupture may simply reflect greater relative aortic dilatation in women who have smaller aortas to begin with, this has never been quantified. Our objective was therefore to quantify the relationship between rupture and aneurysm diameter relative to body size and to determine whether a differential association between aneurysm diameter, body size, and rupture risk exists for men and women. Methods We performed a retrospective review of all patients in the Vascular Study Group of New England (VSGNE) database who underwent endovascular or open AAA repair. Using each patient’s height and weight, body mass index (BMI) and body surface area (BSA) were calculated. Next, indices of each measure of body size (height, weight, BMI, BSA) relative to aneurysm diameter were calculated for each patient. To generate these indices, we divided aneurysm diameter (in cm) by the measure of body size [e.g. aortic size index (ASI) = aneurysm diameter (cm) / BSA (m2)]. Along with other relevant clinical variables, we used these indices to construct different age-adjusted and multivariable-adjusted logistic regression models to determine predictors of ruptured repair vs. elective repair. Models for men and women were developed separately and different models were compared using the area under the curve (AUC). Results We identified 4045 patients who underwent AAA repair (78% male, 53% EVAR). Women had significantly smaller diameter aneurysms, lower BSA, and higher BSA indices than men (Table 1). For men, the variable that increased the odds of rupture the most was aneurysm diameter (AUC = 0.82). Men exhibited an increased rupture risk with increasing aneurysm diameter (<5.5cm: OR 1.0; 5.5–6.4cm: OR 0.9, 95% CI 0.5–1

  2. AAAS Mass Media Science and Engineering Fellowship Program: Building Communication Skills in Young Scientists

    NASA Astrophysics Data System (ADS)

    Pasco, S.

    2006-12-01

    The AAAS Mass Media Science &Engineering Fellowship program has succeeded in training scientists to become more effective communicators for more than 30 years. The program places advanced science, engineering and mathematics students at media sites to work as science reporters for ten weeks each summer. AAAS places between 15 to 20 students a year at newspapers, magazines and radio stations. Our goal is to create better science communicators who understand their role in fostering the public's understanding of science. Fellows leave the program with a greater awareness of how to communicate complex issues by making the connection as to why people should be interested in certain developments, and more specifically, how they will impact their communities. 2004 AGU Fellow Rei Ueyama put her lessons learned to good use during her Fellowship at the Sacramento Bee. "In a regional paper like The Bee, a (story) also had to have a local touch. I needed to show why people in Sacramento (or California) should bother to read the story. One example is the story I wrote about seeding the ocean with iron particles to fight global warming. Since ocean fertilization is a global issue, I had to clearly specify the reason why The Bee and not The New York Times was running the story. The local angle I chose was to point out that the core group of scientists involved in this study was from Monterey Bay, Calif." Many alumni tell us the program has been an integral force in shaping the course of their career. Similarly, sites often report that having a scientist on staff is an invaluable resource that allows them to cover additional science stories as well as report some technical stories in more depth. The American Geophysical Union has sponsored a Mass Media Fellow since 1997. Sponsorship allows affiliate program partners to establish connections with young professionals in their field. They are then also able to take advantage of the communication skills resident in their alumni base

  3. Symmetries and soliton solutions of the Galilean complex Sine-Gordon equation

    NASA Astrophysics Data System (ADS)

    de Melo, G. R.; de Montigny, M.; Pinfold, J.; Tuszynski, J. A.

    2016-03-01

    We discuss a new equation, the Galilean version of the complex Sine-Gordon equation in 1 + 1 dimensions, Ψxx (1 -Ψ* Ψ) + 2 imΨt +Ψ* Ψx2- Ψ(1 -Ψ* Ψ) 2 = 0, derived from its relativistic counterpart via Galilean covariance. We determine its Lie point symmetries, discuss some group-invariant solutions, and examine some soliton solutions. The reduction under Galilean symmetry leads to an equation similar to the stationary Gross-Pitaevskii equation. This work is motivated in part by recent applications of the relativistic complex Sine-Gordon equation to the dynamics of Q-balls.

  4. Wigner function for Klein-Gordon oscillator in commutative and noncommutative spaces

    NASA Astrophysics Data System (ADS)

    Hassanabadi, S.; Ghominejad, M.

    2016-06-01

    As a quasi-probability distribution function in phase-space and a special representation of the density matrix, the Wigner function is of great significance in physics. In this work, the Wigner function for the Klein-Gordon oscillator is studied in commutative and noncommutative spaces. We first study the Wigner function for Klein-Gordon oscillator in commutative space then, by using a generalized Bopp's shift method, we obtain the corresponding Wigner function in noncommutative space. The additional terms in Wigner function on a NC space is related to the noncommutativity of space.

  5. Hydrodynamic representation of the Klein-Gordon-Einstein equations in the weak field limit

    NASA Astrophysics Data System (ADS)

    Suárez, Abril; Chavanis, Pierre-Henri

    2015-11-01

    Using a generalization of the Madelung transformation, we derive the hydrodynamic representation of the Klein-Gordon-Einstein equations in the weak field limit. We consider a complex self-interacting scalar field with an arbitrary potential of the form V(|ϕ|2). We compare the results with simplified models in which the gravitational potential is introduced by hand in the Klein-Gordon equation, and assumed to satisfy a (generalized) Poisson equation. Nonrelativistic hydrodynamic equations based on the Schrodinger-Poisson equations or on the Gross-Pitaevskii-Poisson equations are recovered in the limit c → +∞.

  6. Kink topology control by high-frequency external forces in nonlinear Klein-Gordon models

    NASA Astrophysics Data System (ADS)

    Alvarez-Nodarse, R.; Quintero, N. R.; Mertens, F. G.

    2014-10-01

    A method of averaging is applied to study the dynamics of a kink in the damped double sine-Gordon equation driven by both external (nonparametric) and parametric periodic forces at high frequencies. This theoretical approach leads to the study of a double sine-Gordon equation with an effective potential and an effective additive force. Direct numerical simulations show how the appearance of two connected π kinks and of an individual π kink can be controlled via the frequency. An anomalous negative mobility phenomenon is also predicted by theory and confirmed by simulations of the original equation.

  7. Kink topology control by high-frequency external forces in nonlinear Klein-Gordon models.

    PubMed

    Alvarez-Nodarse, R; Quintero, N R; Mertens, F G

    2014-10-01

    A method of averaging is applied to study the dynamics of a kink in the damped double sine-Gordon equation driven by both external (nonparametric) and parametric periodic forces at high frequencies. This theoretical approach leads to the study of a double sine-Gordon equation with an effective potential and an effective additive force. Direct numerical simulations show how the appearance of two connected π kinks and of an individual π kink can be controlled via the frequency. An anomalous negative mobility phenomenon is also predicted by theory and confirmed by simulations of the original equation.

  8. Sine-Gordon quantum mechanics on the complex plane and N=2 gauge theory

    SciTech Connect

    He Wei

    2010-05-15

    We study the relation between the N=2 gauge theory in the {Omega} background and the quantized integral system recently proposed by Nekrasov and Shatashvili. We focus on the simplest case, the pure Yang-Mills theory with the SU(2) gauge group and the corresponding sine-Gordon integral model on the complex plane. We analyze the periodic wave function and the corresponding energy spectrum of the sine-Gordon quantum mechanics, and find this model contains information of the low energy effective theory of the gauge theory.

  9. {pi} kinks in the parametrically driven sine-Gordon equation and applications

    SciTech Connect

    Zharnitsky, V.; Mitkov, I.

    1997-07-08

    Parametrically driven sine-Gordon equation with a mean-zero forcing is considered. It is shown that the system is well approximated by the double sine-Gordon equation using the normal form technique. The reduced equation possesses {pi}-kink solutions, which are also observed numerically in the original system. This result is applied to domain walls dynamics in one-dimensional easy-plane ferromagnets. For such system the existence of {pi}-kinks implies the true domain structure in the presence of high-frequency magnetic field.

  10. Scattering of Klein–Gordon particles by a Kink-like potential

    SciTech Connect

    Hassanabadi, H.; Lu, Liangliang; Maghsoodi, E.; Liu, Guanghui; Zarrinkamar, S.

    2014-03-15

    The Klein–Gordon equation for the non-minimal vector and a scalar Kink-like potential is solved in terms of the hypergeometric functions. The scattering problem, i.e. the transmission and reflection coefficients, is studied as well. -- Highlights: •The Klein–Gordon equation for the non-minimal vector and a scalar Kink-like potential is solved. •We have calculated the corresponding transmission and reflection coefficients. •We discussed the behavior of the reflection and transmission coefficients vs. energy.

  11. 2012 Molecular Basis of Microbial One-Carbon Metabolism Gordon Research Conferences and Gordon Research Seminar, August 4-10,2012

    SciTech Connect

    Hanson, Thomas

    2012-08-10

    The 2012 Gordon Conference will present and discuss cutting-edge research in the field of microbial metabolism of C1 compounds. The conference will feature the roles and application of C1 metabolism in natural and synthetic systems at scales from molecules to ecosystems. The conference will stress molecular aspects of the unique metabolism exhibited by autotrophic bacteria, methanogens, methylotrophs, aerobic and anaerobic methanotrophs, and acetogens.

  12. Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus.

    PubMed

    Vass, Robert H; Chien, Peter

    2013-11-01

    Chromosome replication relies on sliding clamps that are loaded by energy-dependent complexes. In Escherichia coli, the ATP-binding clamp loader subunit DnaX exists as both long (τ) and short (γ) forms generated through programmed translational frameshifting, but the need for both forms is unclear. Here, we show that in Caulobacter crescentus, DnaX isoforms are unexpectedly generated through partial proteolysis by the AAA+ protease casein lytic proteinase (Clp) XP. We find that the normally processive ClpXP protease partially degrades DnaX to produce stable fragments upon encountering a glycine-rich region adjacent to a structured domain. Increasing the sequence complexity of this region prevents partial proteolysis and generates a τ-only form of DnaX in vivo that is unable to support viability on its own. Growth is restored when γ is provided in trans, but these strains are more sensitive to DNA damage compared with strains that can generate γ through proteolysis. Our work reveals an unexpected mode of partial processing by the ClpXP protease to generate DnaX isoforms, demonstrates that both τ and γ forms of DnaX are required for Caulobacter viability, and identifies a role for clamp loader diversity in responding to DNA damage. The conservation of distinct DnaX isoforms throughout bacteria despite fundamentally different mechanisms for producing them suggests there may be a conserved need for alternate clamp loader complexes during DNA damaging conditions.

  13. Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation.

    PubMed

    Gal, Csenge; Murton, Heather E; Subramanian, Lakxmi; Whale, Alex J; Moore, Karen M; Paszkiewicz, Konrad; Codlin, Sandra; Bähler, Jürg; Creamer, Kevin M; Partridge, Janet F; Allshire, Robin C; Kent, Nicholas A; Whitehall, Simon K

    2016-01-01

    Maintenance of the correct level and organisation of nucleosomes is crucial for genome function. Here, we uncover a role for a conserved bromodomain AAA-ATPase, Abo1, in the maintenance of nucleosome architecture in fission yeast. Cells lacking abo1(+) experience both a reduction and mis-positioning of nucleosomes at transcribed sequences in addition to increased intragenic transcription, phenotypes that are hallmarks of defective chromatin re-establishment behind RNA polymerase II. Abo1 is recruited to gene sequences and associates with histone H3 and the histone chaperone FACT. Furthermore, the distribution of Abo1 on chromatin is disturbed by impaired FACT function. The role of Abo1 extends to some promoters and also to silent heterochromatin. Abo1 is recruited to pericentromeric heterochromatin independently of the HP1 ortholog, Swi6, where it enforces proper nucleosome occupancy. Consequently, loss of Abo1 alleviates silencing and causes elevated chromosome mis-segregation. We suggest that Abo1 provides a histone chaperone function that maintains nucleosome architecture genome-wide.

  14. Simulation of bifurcated stent grafts to treat abdominal aortic aneurysms (AAA)

    NASA Astrophysics Data System (ADS)

    Egger, J.; Großkopf, S.; Freisleben, B.

    2007-03-01

    In this paper a method is introduced, to visualize bifurcated stent grafts in CT-Data. The aim is to improve therapy planning for minimal invasive treatment of abdominal aortic aneurysms (AAA). Due to precise measurement of the abdominal aortic aneurysm and exact simulation of the bifurcated stent graft, physicians are supported in choosing a suitable stent prior to an intervention. The presented method can be used to measure the dimensions of the abdominal aortic aneurysm as well as simulate a bifurcated stent graft. Both of these procedures are based on a preceding segmentation and skeletonization of the aortic, right and left iliac. Using these centerlines (aortic, right and left iliac) a bifurcated initial stent is constructed. Through the implementation of an ACM method the initial stent is fit iteratively to the vessel walls - due to the influence of external forces (distance- as well as balloonforce). Following the fitting process, the crucial values for choosing a bifurcated stent graft are measured, e.g. aortic diameter, right and left common iliac diameter, minimum diameter of distal neck. The selected stent is then simulated to the CT-Data - starting with the initial stent. It hereby becomes apparent if the dimensions of the bifurcated stent graft are exact, i.e. the fitting to the arteries was done properly and no ostium was covered.

  15. CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease.

    PubMed

    Strauss, Kevin A; Jinks, Robert N; Puffenberger, Erik G; Venkatesh, Sundararajan; Singh, Kamalendra; Cheng, Iteen; Mikita, Natalie; Thilagavathi, Jayapalraja; Lee, Jae; Sarafianos, Stefan; Benkert, Abigail; Koehler, Alanna; Zhu, Anni; Trovillion, Victoria; McGlincy, Madeleine; Morlet, Thierry; Deardorff, Matthew; Innes, A Micheil; Prasad, Chitra; Chudley, Albert E; Lee, Irene Nga Wing; Suzuki, Carolyn K

    2015-01-01

    CODAS syndrome is a multi-system developmental disorder characterized by cerebral, ocular, dental, auricular, and skeletal anomalies. Using whole-exome and Sanger sequencing, we identified four LONP1 mutations inherited as homozygous or compound-heterozygous combinations among ten individuals with CODAS syndrome. The individuals come from three different ancestral backgrounds (Amish-Swiss from United States, n = 8; Mennonite-German from Canada, n = 1; mixed European from Canada, n = 1). LONP1 encodes Lon protease, a homohexameric enzyme that mediates protein quality control, respiratory-complex assembly, gene expression, and stress responses in mitochondria. All four pathogenic amino acid substitutions cluster within the AAA(+) domain at residues near the ATP-binding pocket. In biochemical assays, pathogenic Lon proteins show substrate-specific defects in ATP-dependent proteolysis. When expressed recombinantly in cells, all altered Lon proteins localize to mitochondria. The Old Order Amish Lon variant (LONP1 c.2161C>G[p.Arg721Gly]) homo-oligomerizes poorly in vitro. Lymphoblastoid cell lines generated from affected children have (1) swollen mitochondria with electron-dense inclusions and abnormal inner-membrane morphology; (2) aggregated MT-CO2, the mtDNA-encoded subunit II of cytochrome c oxidase; and (3) reduced spare respiratory capacity, leading to impaired mitochondrial proteostasis and function. CODAS syndrome is a distinct, autosomal-recessive, developmental disorder associated with dysfunction of the mitochondrial Lon protease.

  16. Development and Analysis of Synthetic Composite Materials Emulating Patient AAA Wall Material Properties

    NASA Astrophysics Data System (ADS)

    Margossian, Christa M.

    Abdominal Aortic Aneurysm (AAA) rupture accounts for 14,000 deaths a year in the United States. Since the number of ruptures has not decreased significantly in recent years despite improvements in imaging and surgical procedures, there is a need for an accurate, noninvasive technique capable of establishing rupture risk for specific patients and discriminating lesions at high risk. In this project, synthetic composite materials replicating patient-specific wall stiffness and strength were developed and their material properties evaluated. Composites utilizing various fibers were developed to give a range of stiffness from 1825.75 kPa up through 8187.64 kPa with one base material, Sylgard 170. A range of strength from 631.12 kPa to 1083 kPa with the same base material was also found. By evaluating various base materials and various reinforcing fibers, a catalogue of stiffnesses and strengths was started to allow for adaptation to specific patient properties. Three specific patient properties were well-matched with two composites fabricated: silk thread-reinforced Sylgard 170 and silk thread-reinforced Dragon Skin 20. The composites showed similar stiffnesses to the specific patients while reaching target stresses at particular strains. Not all patients were matched with composites as of yet, but recommendations for future matches are able to be determined. These composites will allow for the future evaluation of flow-induced wall stresses in models replicating patient material properties and geometries.

  17. AAA-ATPase FIDGETIN-LIKE 1 and Helicase FANCM Antagonize Meiotic Crossovers by Distinct Mechanisms

    PubMed Central

    Girard, Chloe; Chelysheva, Liudmila; Choinard, Sandrine; Froger, Nicole; Macaisne, Nicolas; Lehmemdi, Afef; Mazel, Julien; Crismani, Wayne; Mercier, Raphael

    2015-01-01

    Meiotic crossovers (COs) generate genetic diversity and are critical for the correct completion of meiosis in most species. Their occurrence is tightly constrained but the mechanisms underlying this limitation remain poorly understood. Here we identified the conserved AAA-ATPase FIDGETIN-LIKE-1 (FIGL1) as a negative regulator of meiotic CO formation. We show that Arabidopsis FIGL1 limits CO formation genome-wide, that FIGL1 controls dynamics of the two conserved recombinases DMC1 and RAD51 and that FIGL1 hinders the interaction between homologous chromosomes, suggesting that FIGL1 counteracts DMC1/RAD51-mediated inter-homologue strand invasion to limit CO formation. Further, depleting both FIGL1 and the previously identified anti-CO helicase FANCM synergistically increases crossover frequency. Additionally, we showed that the effect of mutating FANCM on recombination is much lower in F1 hybrids contrasting from the phenotype of inbred lines, while figl1 mutation equally increases crossovers in both contexts. This shows that the modes of action of FIGL1 and FANCM are differently affected by genomic contexts. We propose that FIGL1 and FANCM represent two successive barriers to CO formation, one limiting strand invasion, the other disassembling D-loops to promote SDSA, which when both lifted, leads to a large increase of crossovers, without impairing meiotic progression. PMID:26161528

  18. Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus

    PubMed Central

    Vass, Robert H.; Chien, Peter

    2013-01-01

    Chromosome replication relies on sliding clamps that are loaded by energy-dependent complexes. In Escherichia coli, the ATP-binding clamp loader subunit DnaX exists as both long (τ) and short (γ) forms generated through programmed translational frameshifting, but the need for both forms is unclear. Here, we show that in Caulobacter crescentus, DnaX isoforms are unexpectedly generated through partial proteolysis by the AAA+ protease casein lytic proteinase (Clp) XP. We find that the normally processive ClpXP protease partially degrades DnaX to produce stable fragments upon encountering a glycine-rich region adjacent to a structured domain. Increasing the sequence complexity of this region prevents partial proteolysis and generates a τ-only form of DnaX in vivo that is unable to support viability on its own. Growth is restored when γ is provided in trans, but these strains are more sensitive to DNA damage compared with strains that can generate γ through proteolysis. Our work reveals an unexpected mode of partial processing by the ClpXP protease to generate DnaX isoforms, demonstrates that both τ and γ forms of DnaX are required for Caulobacter viability, and identifies a role for clamp loader diversity in responding to DNA damage. The conservation of distinct DnaX isoforms throughout bacteria despite fundamentally different mechanisms for producing them suggests there may be a conserved need for alternate clamp loader complexes during DNA damaging conditions. PMID:24145408

  19. CODAS Syndrome Is Associated with Mutations of LONP1, Encoding Mitochondrial AAA+ Lon Protease

    PubMed Central

    Strauss, Kevin A.; Jinks, Robert N.; Puffenberger, Erik G.; Venkatesh, Sundararajan; Singh, Kamalendra; Cheng, Iteen; Mikita, Natalie; Thilagavathi, Jayapalraja; Lee, Jae; Sarafianos, Stefan; Benkert, Abigail; Koehler, Alanna; Zhu, Anni; Trovillion, Victoria; McGlincy, Madeleine; Morlet, Thierry; Deardorff, Matthew; Innes, A. Micheil; Prasad, Chitra; Chudley, Albert E.; Lee, Irene Nga Wing; Suzuki, Carolyn K.

    2015-01-01

    CODAS syndrome is a multi-system developmental disorder characterized by cerebral, ocular, dental, auricular, and skeletal anomalies. Using whole-exome and Sanger sequencing, we identified four LONP1 mutations inherited as homozygous or compound-heterozygous combinations among ten individuals with CODAS syndrome. The individuals come from three different ancestral backgrounds (Amish-Swiss from United States, n = 8; Mennonite-German from Canada, n = 1; mixed European from Canada, n = 1). LONP1 encodes Lon protease, a homohexameric enzyme that mediates protein quality control, respiratory-complex assembly, gene expression, and stress responses in mitochondria. All four pathogenic amino acid substitutions cluster within the AAA+ domain at residues near the ATP-binding pocket. In biochemical assays, pathogenic Lon proteins show substrate-specific defects in ATP-dependent proteolysis. When expressed recombinantly in cells, all altered Lon proteins localize to mitochondria. The Old Order Amish Lon variant (LONP1 c.2161C>G[p.Arg721Gly]) homo-oligomerizes poorly in vitro. Lymphoblastoid cell lines generated from affected children have (1) swollen mitochondria with electron-dense inclusions and abnormal inner-membrane morphology; (2) aggregated MT-CO2, the mtDNA-encoded subunit II of cytochrome c oxidase; and (3) reduced spare respiratory capacity, leading to impaired mitochondrial proteostasis and function. CODAS syndrome is a distinct, autosomal-recessive, developmental disorder associated with dysfunction of the mitochondrial Lon protease. PMID:25574826

  20. Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX.

    PubMed

    Kasashima, Katsumi; Sumitani, Megumi; Endo, Hitoshi

    2012-11-01

    The segregation of mitochondrial DNA (mtDNA) is important for the maintenance and transmission of the genome between generations. Recently, we clarified that human mitochondrial transcription factor A (TFAM) is required for equal distribution and symmetric segregation of mtDNA in cultured cells; however, the molecular mechanism involved is largely unknown. ClpX is an ATPase associated with various cellular activities (AAA+) proteins that localize to the mitochondrial matrix and is suggested to associate with mtDNA. In this study, we found that RNAi-mediated knockdown of ClpX in HeLa cells resulted in enlarged mtDNA nucleoids, which is very similar to that observed in TFAM-knockdown cells in several properties. The expression of TFAM protein was not significantly reduced in ClpX-knockdown cells. However, the enlarged mtDNA nucleoids caused by ClpX-knockdown were suppressed by overexpression of recombinant TFAM and the phenotype was not observed in knockdown with ClpP, a protease subunit of ClpXP. Endogenous ClpX and TFAM exist in close vicinity, and ClpX enhanced DNA-binding activity of TFAM in vitro. These results suggest that human ClpX, a novel mtDNA regulator, maintains mtDNA nucleoid distribution through TFAM function as a chaperone rather than as a protease and its involvement in mtDNA segregation. PMID:22841477

  1. ATP-binding sites in brain p97/VCP (valosin-containing protein), a multifunctional AAA ATPase.

    PubMed Central

    Zalk, Ran; Shoshan-Barmatz, Varda

    2003-01-01

    VCP (valosin-containing protein) or p97 is a member of the AAA family (ATPases associated with a variety of cellular activities family), a diverse group of proteins sharing a key conserved AAA module containing duplicate putative ATP-binding sites. Although the functions of the AAA family are related to their putative ATP-binding sites, the binding of ATP to these sites has not yet been demonstrated. In the present study, the ATP-binding site(s) of brain VCP was characterized using the photoreactive ATP analogue, BzATP [3'- O -(4-benzoylbenzoyl)ATP]. Photo-activation of Bz-[alpha-(32)P]ATP resulted in its covalent binding to a 97-kDa purified soluble or membrane-associated protein, identified by amino acid sequencing as VCP. Bz-[alpha-(32)P]ATP covalently bound to the purified homo-hexameric VCP with an apparent high affinity (74-111 nM). A molar stoichiometry of 2.23+/-0.14 BzATP bound per homo-hexameric VCP (n =6) was determined using different methods for analysis of radiolabelling and protein determination. Nucleotides inhibited the binding of Bz-[alpha-(32)P]ATP to VCP with the following efficiency: BzATP>ATP>ADP>>adenosine 5'-[beta,gamma-imido]triphosphate>or=adenosine 5'-[beta,gamma-methylene]triphosphate, whereas AMP, GTP and CTP were ineffective. VCP was observed to possess very low ATPase activity, with nucleotide specificity similar to that for BzATP binding. Conformational changes induced by an alternating site mechanism for ATP binding are suggested as a molecular mechanism for coupling ATP binding to the diverse activities of the AAA family. PMID:12747802

  2. The statistical properties of Klein-Gordon oscillator in noncommutative space

    SciTech Connect

    Hassanabadi, H. Hosseini, S. S.; Boumali, A.; Zarrinkamar, S.

    2014-03-15

    We study the relativistic spin-zero bosons influenced by the Klein-Gordon oscillator and an external magnetic field in noncommutative formulation. The problem is considered in two dimensions and is solved in an exact analytical manner. Having found the spectrum of the system, the statistical properties of an N-boson system are reported.

  3. 2012 ELECTRON DONOR-ACCEPTOR INTERACTIONS GORDON RESEARCH CONFERENCE, AUGUST 5-10, 2012

    SciTech Connect

    McCusker, James

    2012-08-10

    The upcoming incarnation of the Gordon Research Conference on Electron Donor Acceptor Interactions will feature sessions on classic topics including proton-coupled electron transfer, dye-sensitized solar cells, and biological electron transfer, as well as emerging areas such as quantum coherence effects in donor-acceptor interactions, spintronics, and the application of donor-acceptor interactions in chemical synthesis.

  4. Reservoir Characterization of Upper Devonian Gordon Sandstone, Jacksonburg, Stringtown Oil Field, Northwestern West Virginia

    SciTech Connect

    Ameri, S.; Aminian, K.; Avary, K.L.; Bilgesu, H.I.; Hohn, M.E.; McDowell, R.R.; Patchen, D.L.

    2002-05-21

    This report gives results of efforts to determine electrofacies from logs; measure permeability in outcrop to study very fine-scale trends; find the correlation between permeability measured by the minipermeameter and in core plugs, define porosity-permeability flow units; and run the BOAST III reservoir simulator using the flow units defined for the Gordon reservoir.

  5. Stability of Schwarzschild-AdS for the Spherically Symmetric Einstein-Klein-Gordon System

    NASA Astrophysics Data System (ADS)

    Holzegel, Gustav; Smulevici, Jacques

    2013-01-01

    In this paper, we study the global behavior of solutions to the spherically symmetric coupled Einstein-Klein-Gordon (EKG) system in the presence of a negative cosmological constant. For the Klein-Gordon mass-squared satisfying a ≥ -1 (the Breitenlohner-Freedman bound being a > -9/8), we prove that the Schwarzschild-AdS spacetimes are asymptotically stable: Small perturbations of Schwarzschild-AdS initial data again lead to regular black holes, with the metric on the black hole exterior approaching, at an exponential rate, a Schwarzschild-AdS spacetime. The main difficulties in the proof arise from the lack of monotonicity for the Hawking mass and the asymptotically AdS boundary conditions, which render even (part of) the orbital stability intricate. These issues are resolved in a bootstrap argument on the black hole exterior, with the redshift effect and weighted Hardy inequalities playing the fundamental role in the analysis. Both integrated decay and pointwise decay estimates are obtained. As a corollary of our estimates on the Klein-Gordon field, one obtains in particular exponential decay in time of spherically-symmetric solutions to the linear Klein-Gordon equation on Schwarzschild-AdS.

  6. Scattering theory for the Klein-Gordon equation with nondecreasing potentials

    SciTech Connect

    Cruz, Maximino; Arredondo R, Juan H.

    2008-11-15

    The Klein-Gordon equation is considered in the case of nondecreasing potentials. The energy inner product is nonpositive on a subspace of infinite dimension, not consisting entirely of eigenvectors of the associated operator. A scattering theory for this case is developed and asymptotic completeness for generalized Moeller operators is proven.

  7. Grumbling, Raised Eyebrows, and Worse as Gordon Gee Prepares To Leave Brown.

    ERIC Educational Resources Information Center

    Lively, Kit

    2000-01-01

    Reports on controversy Brown University (Rhode Island) as Gordon Gee leaves to become chancellor of Vanderbilt University (Tennessee) after only two years as president of Brown, and notes feelings of betrayal in light of large compensation offered Gee by Vanderbilt. Reports average tenures for college presidents and quotes Gee as saying that he…

  8. Astronauts Jack R. Lousma, right, and C. Gordon Fullerton greet the press

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Astronauts Jack R. Lousma speaks to news media and friends at Ellington Air Force Base after the landing the the Space Shuttle Columbia at the end of the STS-3 mission. Pilot C. Gordon Fullerton, holding his daughter, stands behind him (28929); wide angle view of STS-3 crew and families on podium (28930).

  9. Astronaut Gordon Fullerton first pilot for Shuttle Approach and Landing Test

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Astronaut C. Gordon Fullerton, pilot of the first crew for the Space Shuttle Approach and Landing Tests (ALT), is photographed at the Rockwell International Space Division's Orbiter assembly facility at Palmdale, California on the day of the rollout of the Shuttle Orbiter 101 'Enterprise' spacecraft. The DC-9 size airplane-like Orbiter 101 is in the background.

  10. Spectral averaging of small-amplitude sine-Gordon wave trains

    NASA Astrophysics Data System (ADS)

    Larson, J. W.; Tracy, E. R.

    1988-11-01

    It is well known that the nonlinear Schrödinger equation is the generic envelope description of nonlinear wave trains in the small-amplitude limit. V. E. Zakharov and E. A. Kuznetsov [Physica 18D, 455 (1986)] have shown that for many systems integrable via inverse-scattering techniques it is possible, through the use of multiscale techniques, to derive the nonlinear Schrödinger Lax pair from the Lax pair of the system that is being modulated. It will be shown that this technique of ``multiscale averaging'' can be applied to the sine-Gordon theory to obtain not only the nonlinear Schrödinger Lax pair from the sine-Gordon Lax pair, but also the nonlinear Schrödinger spectral data, conservation laws, Θ-function solutions, and reality constraint from their sine-Gordon counterparts. This allows a physical interpretation of the mathematical elements of the nonlinear Schrödinger envelope in terms of the physical characteristics of the sine-Gordon system that is being modulated.

  11. Scattering and Bound States of Klein-Gordon Particle with Hylleraas Potential Within Effective Mass Formalism

    NASA Astrophysics Data System (ADS)

    Onyeaju, M. C.; Ikot, A. N.; Chukwuocha, E. O.; Obong, H. P.; Zare, S.; Hassanabadi, H.

    2016-06-01

    Scattering and bound states solution for the one-dimensional Klein-Gordon particle with Hylleraas potential is presented within the frame work of position dependent effective mass formalism. We calculate in detail the reflection and transmission coefficients using the properties of hypergeometric functions and the equation of continuity of the wave functions.

  12. Astronaut Gordon Cooper is assisted backing out of his spacecraft 'Faith 7'

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut L. Gordon Cooper is assisted in backing out of his spacecraft 'Faith 7' after a 600,000 mile, 22.9 orbit journey around the earth. He elected to remain in the spacecraft until it was hoisted to the deck of the Kearsarge, as did Astronaut Walter Schirra during the previous mission.

  13. MA-9 ASTRONAUT GORDON COOPER EXPLAINS CAMERA TO BACKUP PILOT ALAN SHEPARD

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut L. Gordon Cooper explains the 16MM handheld spacecraft camera to his back-up pilot Astronaut Alan Shepard. The camera designed by J. R. Hereford, McDonnell Aircraft Corp., will be used by Cooper during the MA-9 mission.

  14. Atlas booster which will lift Astronaut L. Gordon Cooper into space arrives at Cape Canaveral, Fla.

    NASA Technical Reports Server (NTRS)

    1963-01-01

    The Atlas vehicle 130D which will lift Astronaut L. Gordon Cooper into space arrives at Cape Canaveral, Fla. The launch vehicle is a one-and-a-half stage, liquid propellant launch vehicle with five engines: 2 booster engines, 1 sustainer engine, and 2 small vernier engines. These engines produce a total thrust of approximately 360,000 pounds.

  15. A new explicit solution to the lattice sine-Gordon equation

    NASA Astrophysics Data System (ADS)

    Xu, Xiaoxue; Cao, Cewen

    2016-03-01

    Based on a new discrete Lax pair, an elementary explicit solution is found for the lattice sine-Gordon equation through Riemann surface method. It contains only exponential functions, quite different from the usual higher genus solutions, expressed with complicated theta functions. The solutions to the associated models, the lattice potential MKdV equation and a special H3 equation are also discussed.

  16. The acoustical Klein-Gordon equation: the wave-mechanical step and barrier potential functions.

    PubMed

    Forbes, Barbara J; Pike, E Roy; Sharp, David B

    2003-09-01

    The transformed form of the Webster equation is investigated. Usually described as analogous to the Schrödinger equation of quantum mechanics, it is noted that the second-order time dependency defines a Klein-Gordon problem. This "acoustical Klein-Gordon equation" is analyzed with particular reference to the acoustical properties of wave-mechanical potential functions, U(x), that give rise to geometry-dependent dispersions at rapid variations in tract cross section. Such dispersions are not elucidated by other one-dimensional--cylindrical or conical--duct models. Since Sturm-Liouville analysis is not appropriate for inhomogeneous boundary conditions, the exact solution of the Klein-Gordon equation is achieved through a Green's-function methodology referring to the transfer matrix of an arbitrary string of square potential functions, including a square barrier equivalent to a radiation impedance. The general conclusion of the paper is that, in the absence of precise knowledge of initial conditions on the area function, any given potential function will map to a multiplicity of area functions of identical relative resonance characteristics. Since the potential function maps uniquely to the acoustical output, it is suggested that the one-dimensional wave physics is both most accurately and most compactly described within the Klein-Gordon framework.

  17. Scattering and Bound States of Klein-Gordon Particle with Hylleraas Potential Within Effective Mass Formalism

    NASA Astrophysics Data System (ADS)

    Onyeaju, M. C.; Ikot, A. N.; Chukwuocha, E. O.; Obong, H. P.; Zare, S.; Hassanabadi, H.

    2016-09-01

    Scattering and bound states solution for the one-dimensional Klein-Gordon particle with Hylleraas potential is presented within the frame work of position dependent effective mass formalism. We calculate in detail the reflection and transmission coefficients using the properties of hypergeometric functions and the equation of continuity of the wave functions.

  18. Exact Analytical Solution of the Klein-Gordon Equation in the Generalized Woods-Saxon Potential

    NASA Astrophysics Data System (ADS)

    Bayrak, O.; Sahin, D.

    2015-09-01

    The exact analytical solution of the Klein-Gordon equation for the spin-0 particles in the generalized Woods-Saxon potential is presented. The bound state energy eigenvalues and corresponding wave functions are obtained in the closed forms. The correlations between the potential parameters and energy eigenvalues are examined for π0 particles.

  19. Scattering solutions of the Klein-Gordon equation for a step potential with hyperbolic tangent potential

    NASA Astrophysics Data System (ADS)

    Rojas, Clara

    2014-09-01

    We solve the Klein-Gordon equation for a step potential with hyperbolic tangent potential. The scattering solutions are derived in terms of hypergeometric functions. The reflection coefficient R and transmission coefficient T are calculated, we observed superradiance and transmission resonances.

  20. Approximate solutions to the nonlinear Klein-Gordon equation in de Sitter spacetime

    NASA Astrophysics Data System (ADS)

    Yazici, Muhammet; Şengül, Süleyman

    2016-09-01

    We consider initial value problems for the nonlinear Klein-Gordon equation in de Sitter spacetime. We use the differential transform method for the solution of the initial value problem. In order to show the accuracy of results for the solutions, we use the variational iteration method with Adomian's polynomials for the nonlinearity. We show that the methods are effective and useful.

  1. 2004 Electron Donor Acceptor Interactions Gordon Conference - August 8-13, 2004

    SciTech Connect

    GUILFORD JONES BOSTON UNIVERSITY PHOTONICS CENTER 8 ST. MARY'S ST BOSTON, MA 02215

    2005-09-14

    The 2004 Gordon Conference on Donor/Acceptor Interactions will take place at Salve Regina University in Newport, Rhode Island on August 8-13, 2004. The conference will be devoted to the consequences of charge interaction and charge motion in molecular and materials systems.

  2. Renormalization-group analysis of layered sine-Gordon type models

    NASA Astrophysics Data System (ADS)

    Nándori, I.; Nagy, S.; Sailer, K.; Jentschura, U. D.

    2005-10-01

    We analyze the phase structure and the renormalization group (RG) flow of the generalized sine-Gordon models with nonvanishing mass terms, using the Wegner-Houghton RG method in the local potential approximation. Particular emphasis is laid upon the layered sine-Gordon (LSG) model, which is the bosonized version of the multi-flavour Schwinger model and approaches the sum of two "normal", massless sine-Gordon (SG) models in the limit of a vanishing interlayer coupling J. Another model of interest is the massive sine-Gordon (MSG) model. The leading-order approximation to the UV (ultraviolet) RG flow predicts two phases for the LSG as well as for the MSG, just as it would be expected for the SG model, where the two phases are known to be separated by the Coleman fixed point. The presence of finite mass terms (for the LSG and the MSG) leads to corrections to the UV RG flow, which are naturally identified as the "mass corrections". The leading-order mass corrections are shown to have the following consequences: (i) for the MSG model, only one phase persists, and (ii) for the LSG model, the transition temperature is modified. Within the mass-corrected UV scaling laws, the limit of J→0 is thus nonuniform with respect to the phase structure of the model. The modified phase structure of general massive sine-Gordon models is connected with the breaking of symmetries in the internal space spanned by the field variables. For the LSG, the second-order subleading mass corrections suggest that there exists a cross-over regime before the IR scaling sets in, and the nonlinear terms show explicitly that higher-order Fourier modes appear in the periodic blocked potential.

  3. A case report of Gordon's syndrome in a 20-year-old male with free medical family history.

    PubMed

    Kostakis, Ioannis D; Tsoukalas, Nikolaos G; Aravantinos, Dionysios C; Gkizis, Ilias G; Cholidou, Kyriaki G; Papadopoulos, Dimitris P

    2013-01-01

    Gordon's syndrome is a rare autosomal dominant disease that manifests in childhood. It is characterized by hypertension, hyperkalemic hyperchloremic metabolic acidosis, low renin and usually normal aldosterone levels, and it is sensitive to thiazide diuretics. A 20-year-old male with a history of diagnosed Gordon's syndrome was referred to a nephrology clinic for evaluation. The patient, who was under treatment with hydrochlorothiazide, had been diagnosed with Gordon's syndrome at the age of 11, when he presented hypertension and episodes of hyperkalemic hyperchloremic metabolic acidosis. However, none of his relatives had been diagnosed with this syndrome. Therefore, we assume that our patient might be a case of de novo gene mutation.

  4. BÄCKLUND Transformations and Lax Pairs for the Nonlinear Klein-Gordon Equation with Symbolic Computation

    NASA Astrophysics Data System (ADS)

    Xu, Xiao-Ge; Gao, Yi-Tian; Wei, Guang-Mei

    In this paper, the nonlinear Klein-Gordon equation describing the propagation of pulse waves in plasma or waveguide is investigated. With symbolic computation, the generalized Bäcklund Transformations (BTs) for this equation are constructed under different conditions. It is shown that the BTs published in the previous literature for the Sine-Gordon equation, Sinh-Gordon equation, and Liouville equation all turn out to be special cases of the results in the present paper. Moreover, the corresponding Lax pairs are explicitly derived from the obtained BTs through some transformations.

  5. AAA+ proteases and their role in distinct stages along the Vibrio cholerae lifecycle.

    PubMed

    Pressler, Katharina; Vorkapic, Dina; Lichtenegger, Sabine; Malli, Gerald; Barilich, Benjamin P; Cakar, Fatih; Zingl, Franz G; Reidl, Joachim; Schild, Stefan

    2016-09-01

    The facultative human pathogen Vibrio cholerae has to adapt to different environmental conditions along its lifecycle by means of transcriptional, translational and post-translational regulation. This study provides a first comprehensive analysis regarding the contribution of the cytoplasmic AAA+ proteases Lon, ClpP and HslV to distinct features of V. cholerae behaviour, including biofilm formation, motility, cholera toxin expression and colonization fitness in the mouse model. While absence of HslV did not yield to any altered phenotype compared to wildtype, absence of Lon or ClpP resulted in significantly reduced colonization in vivo. In addition, a Δlon deletion mutant showed altered biofilm formation and increased motility, which could be correlated with higher expression of V. cholerae flagella gene class IV. Concordantly, we could show by immunoblot analysis, that Lon is the main protease responsible for proteolytic control of FliA, which is required for class IV flagella gene transcription, but also downregulates virulence gene expression. FliA becomes highly sensitive to proteolytic degradation in absence of its anti-sigma factor FlgM, a scenario reported to occur during mucosal penetration due to FlgM secretion through the broken flagellum. Our results confirm that the high stability of FliA in the absence of Lon results in less cholera toxin and toxin corgulated pilus production under virulence gene inducing conditions and in the presence of a damaged flagellum. Thus, the data presented herein provide a molecular explanation on how V. cholerae can achieve full expression of virulence genes during early stages of colonization, despite FliA getting liberated from the anti-sigma factor FlgM. PMID:27345492

  6. A proteomic study of Corynebacterium glutamicum AAA+ protease FtsH

    PubMed Central

    Lüdke, Alja; Krämer, Reinhard; Burkovski, Andreas; Schluesener, Daniela; Poetsch, Ansgar

    2007-01-01

    Background The influence of the membrane-bound AAA+ protease FtsH on membrane and cytoplasmic proteins of Corynebacterium glutamicum was investigated in this study. For the analysis of the membrane fraction, anion exchange chromatography was combined with SDS-PAGE, while the cytoplasmic protein fraction was studied by conventional two-dimensional gel electrophoresis. Results In contrast to the situation in other bacteria, deletion of C. glutamicum ftsH has no significant effect on growth in standard minimal medium or response to heat or osmotic stress. On the proteome level, deletion of the ftsH gene resulted in a strong increase of ten cytoplasmic and membrane proteins, namely biotin carboxylase/biotin carboxyl carrier protein (accBC), glyceraldehyde-3-phosphate dehydrogenase (gap), homocysteine methyltransferase (metE), malate synthase (aceB), isocitrate lyase (aceA), a conserved hypothetical protein (NCgl1985), succinate dehydrogenase A (sdhA), succinate dehydrogenase B (sdhB), succinate dehydrogenase CD (sdhCD), and glutamate binding protein (gluB), while 38 cytoplasmic and membrane-associated proteins showed a decreased abundance. The decreasing amount of succinate dehydrogenase A (sdhA) in the cytoplasmic fraction of the ftsH mutant compared to the wild type and its increasing abundance in the membrane fraction indicates that FtsH might be involved in the cleavage of a membrane anchor of this membrane-associated protein and by this changes its localization. Conclusion The data obtained hint to an involvement of C. glutamicum FtsH protease mainly in regulation of energy and carbon metabolism, while the protease is not involved in stress response, as found in other bacteria. PMID:17254330

  7. Crystal structure of a novel archaeal AAA+ ATPase SSO1545 from Sulfolobus solfataricus

    SciTech Connect

    Xu, Qingping; Rife, Christopher L.; Carlton, Dennis; Miller, Mitchell D.; Krishna, S. Sri; Elsliger, Marc-André; Abdubek, Polat; Astakhova, Tamara; Chiu, Hsiu-Ju; Clayton, Thomas; Duan, Lian; Feuerhelm, Julie; Grzechnik, Slawomir K.; Hale, Joanna; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kumar, Abhinav; McMullan, Daniel; Morse, Andrew T.; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Reyes, Ron; van den Bedem, Henry; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2009-08-28

    Signal transduction ATPases with numerous domains (STAND), a large class of P-loop NTPases, belong to AAA+ ATPases. They include AP(apoptotic)-ATPases (e.g., animal apoptosis regulators CED4/Apaf-1, plant disease resistance proteins, and bacterial AfsR-like transcription regulators), NACHT NTPases (e.g. CARD4, NAIP, Het-E-1, TLP1), and several other less well-characterized families. STAND differ from other P-loop NTPases by their unique sequence motifs, which include an hhGRExE (h, hydrophobic; x, any residue) motif at the N-terminal region, a GxP/GxxP motif at the C-terminal region of the NTPase domain, in addition to a C-terminal helical domain and additional domains such as WD40, TPR, LRR or catalytic modules. Despite significant biological interests, structural coverage of STAND proteins is very limited and only two other structures are currently known: the cell death regulators Apaf-1 and CED-4. Here, we report the crystal structure of SSO1545 from Sulfolobus solfataricus, which was determined using the semi-automated, high-throughput pipeline of the Joint Center for Structural Genomics (JCSG; http://www.jcsg.org), as part of the National Institute of General Medical Sciences' Protein Structure Initiative (PSI). SSO1545 (NP-342973.1), a representative of the archaeal STANDs, is a member of Pfam PF01637 and encodes a protein of 356 residues with calculated molecular weight and isoelectric point of 41.7 kD and 8.2, respectively.

  8. Prevalence of previously undiagnosed abdominal aortic aneurysms in the area of Como: the ComoCuore "looking for AAA" ultrasonography screening.

    PubMed

    Corrado, Giovanni; Durante, Alessandro; Genchi, Vincenzo; Trabattoni, Loris; Beretta, Sandro; Rovelli, Enza; Foglia-Manzillo, Giovanni; Ferrari, Giovanni

    2016-08-01

    The prognosis for abdominal aortic aneurysm (AAA) rupture is poor. Long-term follow-up of population-based randomized trials has demonstrated that ultrasound (US) screening for abdominal aortic aneurysms (AAAs) measuring 3 cm or greater decreases AAA-related mortality rates and is cost-effective. We though to prospectively perform during a 26-month period a limited US examination of the infrarenal aorta in volunteers of both gender aged 60-85 years without history of AAA living in the area of Como, Italy. From September 2010 to November 2013 ComoCuore, a no-profit nongovernmental association, enrolled 1555 people (aged 68.8 ± 6.8 years; 48.6 % males). Clinical data and a US imaging of the aorta were collected for each participant. AAA was found in 22 volunteers (1.4 %) mainly males (2.5 % in males vs. 0.4 % in females p = 0.005). Overall, the prevalence of cardiovascular risk factors was higher in patients with vs. without AAA (mean 2.9 ± 3.0 vs. 1.4 ± 1.0 respectively, p < 0.0001). Independent predictors of AAA on multivariate analysis were age (OR 1.14, 1.06-1.22; p < 0.0001), male gender (OR 8.23, 1.79-37.91; p = 0.007), and both current (OR 4.98, 1.57-15.79; p = 0.007) and previous smoking (OR 2.76, 1.12-8.94; p = 0.03). Our study confirms the feasibility of one time US screening for AAA in a large cohort of asymptomatic people. Independent predictors of AAA were male sex, older age and a history of smoking. Accordingly to recent data the prevalence of AAA seems to be declining, maybe due to a reduction of smoking in Italy. PMID:27215751

  9. Prevalence of previously undiagnosed abdominal aortic aneurysms in the area of Como: the ComoCuore "looking for AAA" ultrasonography screening.

    PubMed

    Corrado, Giovanni; Durante, Alessandro; Genchi, Vincenzo; Trabattoni, Loris; Beretta, Sandro; Rovelli, Enza; Foglia-Manzillo, Giovanni; Ferrari, Giovanni

    2016-08-01

    The prognosis for abdominal aortic aneurysm (AAA) rupture is poor. Long-term follow-up of population-based randomized trials has demonstrated that ultrasound (US) screening for abdominal aortic aneurysms (AAAs) measuring 3 cm or greater decreases AAA-related mortality rates and is cost-effective. We though to prospectively perform during a 26-month period a limited US examination of the infrarenal aorta in volunteers of both gender aged 60-85 years without history of AAA living in the area of Como, Italy. From September 2010 to November 2013 ComoCuore, a no-profit nongovernmental association, enrolled 1555 people (aged 68.8 ± 6.8 years; 48.6 % males). Clinical data and a US imaging of the aorta were collected for each participant. AAA was found in 22 volunteers (1.4 %) mainly males (2.5 % in males vs. 0.4 % in females p = 0.005). Overall, the prevalence of cardiovascular risk factors was higher in patients with vs. without AAA (mean 2.9 ± 3.0 vs. 1.4 ± 1.0 respectively, p < 0.0001). Independent predictors of AAA on multivariate analysis were age (OR 1.14, 1.06-1.22; p < 0.0001), male gender (OR 8.23, 1.79-37.91; p = 0.007), and both current (OR 4.98, 1.57-15.79; p = 0.007) and previous smoking (OR 2.76, 1.12-8.94; p = 0.03). Our study confirms the feasibility of one time US screening for AAA in a large cohort of asymptomatic people. Independent predictors of AAA were male sex, older age and a history of smoking. Accordingly to recent data the prevalence of AAA seems to be declining, maybe due to a reduction of smoking in Italy.

  10. Celebrating the Fiftieth Baker Gordon Symposium on Cosmetic Surgery: The Legacy of Thomas J. Baker, M.D.

    PubMed

    Stuzin, James M

    2016-02-01

    The Baker Gordon Symposium on Cosmetic Surgery celebrates its fiftieth year. A review of its history mirrors the evolution of aesthetic surgery in terms of advancements in techniques, and the acceptance of cosmetic surgery as a credible subspecialty of plastic surgery. Beginning in 1967, the Baker Gordon Symposium was the first live surgery symposium that focused on aesthetic surgery, and set a precedent for aesthetic surgery education over the ensuing decades. Historically, the pioneers in aesthetic techniques first presented their innovations at the Baker Gordon Symposium, helping to educate and train their peers to perform cosmetic procedures. The legacy of Thomas Baker is intertwined with the history of the Baker Gordon Symposium, both in terms of his contributions to plastic surgery education, and to the acceptance of the subspecialty of aesthetic surgery.

  11. Shannon information entropies for the three-dimensional Klein-Gordon problem with the Poschl-Teller potential

    NASA Astrophysics Data System (ADS)

    Ghafourian, M.; Hassanabadi, H.

    2016-06-01

    The Shannon information entropies for the Klein-Gordon equations are evaluated for the Poschl-Teller potential, and the position-space information entropies for the ground and the excited states are calculated.

  12. Support for the 2001 Gordon Research Conference on the Origins of Solar Systems

    NASA Technical Reports Server (NTRS)

    Stevenson, David J.

    2002-01-01

    This grant provided partial support for participants at the Gordon Research Conference on Origins of Solar Systems, held at Connecticut College, June 17 through June 22, 2001. This conference was chaired by the PI (David Stevenson) and Pat Cassell (NASA Ames) was Vice-Chair. In addition to the money provided by this grant ($15,000), the Gordon Research Conference organization provided about $22,000 (in large part from registration fees) and BPI provided $10,000 (through Director David Black); the latter targeted primarily for students and postdocs. Accordingly the grant money from NASA was used to cover the costs of registration and travel for about one half of the invited speakers (22 in total) and discussion leaders (about 10 in total).

  13. 2011 Photochemistry Gordon Research Conference (July10-15, 2011, Stonehill College, Easton, MA)

    SciTech Connect

    Prof. Gerald Meyer

    2011-07-15

    Photochemistry has wide implications on fundamental science with technological applications that range from synthetic and mechanistic organic and inorganic chemistry to sensing/manipulation in the biological sciences to viable solar energy conversion assemblies. The 2011 Gordon Research Conference on Photochemistry will highlight recent advances on photochemical reactions, their mechanisms, spectroscopic techniques and applications to materials, organic synthesis, and biology. The conference will continue its long tradition on dynamic discussions on recent advances and unsolved scientific problems. The format of lectures, poster presentations and informal discussions provides an ideal venue for students and post-doctoral fellows to interact with the leaders in the field. These junior scientists will have an opportunity to participate in the Gordon Research Seminar on Photochemistry to be held prior to the GRC. The GRS will focus on photochemical aspects of solar energy conversion. Four abstracts for posters at the GRC and presentations at the GRS will be selected as short talks at the GRC.

  14. Mathematical model of the shooter's position during shooting using Gordon's method

    NASA Astrophysics Data System (ADS)

    Zulkifli, Wan Nur Syazana Wan; Din, Wan Rozita Wan; Rambely, Azmin Sham

    2014-10-01

    The aim of this study was to develop a mathematical biomechanical modeling of a shooter's position while firing a rifle for accurate shooting. Gordon's method has been used to develop the model. This model comprises of six kinematic chains of the arms that represent the right shoulder joint, right elbow joint, right wrist joint, left shoulder joint, left elbow joint and left wrist joint. Gordon's method uses Kane's method to formulate the n dynamic equations of motion for n-link planar linkage to be written down without having to derive them. The findings should provide the correct angles of elbows, shoulders and wrist for left and right hands of soldiers while aiming at the target. Torque will be calculated from the model developed and the results obtained can assist the army or sportsman in order to obtain the correct posture while aiming.

  15. Form factors of descendant operators: resonance identities in the sinh-Gordon model

    NASA Astrophysics Data System (ADS)

    Lashkevich, Michael; Pugai, Yaroslav

    2014-12-01

    We study the space of local operators in the sinh-Gordon model in the framework of the bootstrap form factor approach. Our final goal is to identify the operators obtained by solving bootstrap equations with those defined in terms of the Lagrangian field. Here we try to identify operators at some very particular points, where the phenomenon of operator resonance takes place. The operator resonance phenomenon being perturbative, nevertheless, results in exact identities between some local operators. By applying an algebraic approach developed earlier for form factors we derive an infinite set of identities between particular descendant and exponential operators in the sinh-Gordon theory, which generalize the quantum equation of motion. We identify the corresponding descendant operators by comparing them with the result of perturbation theory.

  16. Darboux Transformation for the Vector Sine-Gordon Equation and Integrable Equations on a Sphere

    NASA Astrophysics Data System (ADS)

    Mikhailov, Alexander V.; Papamikos, Georgios; Wang, Jing Ping

    2016-07-01

    We propose a method for construction of Darboux transformations, which is a new development of the dressing method for Lax operators invariant under a reduction group. We apply the method to the vector sine-Gordon equation and derive its Bäcklund transformations. We show that there is a new Lax operator canonically associated with our Darboux transformation resulting an evolutionary differential-difference system on a sphere. The latter is a generalised symmetry for the chain of Bäcklund transformations. Using the re-factorisation approach and the Bianchi permutability of the Darboux transformations, we derive new vector Yang-Baxter map and integrable discrete vector sine-Gordon equation on a sphere.

  17. Quantum quenches in the sinh-Gordon model: steady state and one-point correlation functions

    NASA Astrophysics Data System (ADS)

    Bertini, Bruno; Piroli, Lorenzo; Calabrese, Pasquale

    2016-06-01

    We consider quantum quenches to the sinh-Gordon integrable quantum field theory from a particular class of initial states. Our analysis includes the case of mass and interaction quenches starting from a non-interacting theory. By means of the recently developed quench action method, we fully characterize the stationary state reached at long times after the quench in terms of the corresponding rapidity distribution. We also provide exact results for the expectation values of arbitrary vertex operators in the post-quench stationary state by proposing a formula based on the analogy with the standard thermodynamic Bethe ansatz. Finally, we comment on the behavior of the post-quench stationary state under the mapping between the sinh-Gordon field theory and the one-dimensional Lieb-Liniger model.

  18. Nonlinear self-adjointness and conservation laws of Klein-Gordon-Fock equation with central symmetry

    NASA Astrophysics Data System (ADS)

    Abdulwahhab, Muhammad Alim

    2015-05-01

    The concept of nonlinear self-adjointness, introduced by Ibragimov, has significantly extends approaches to constructing conservation laws associated with symmetries since it incorporates the strict self-adjointness, the quasi self-adjointness as well as the usual linear self-adjointness. Using this concept, the nonlinear self-adjointness condition for the Klein-Gordon-Fock equation was established and subsequently used to construct simplified but infinitely many nontrivial and independent conserved vectors. The Noether's theorem was further applied to the Klein-Gordon-Fock equation to explore more distinct first integrals, result shows that conservation laws constructed through this approach are exactly the same as those obtained under strict self-adjointness of Ibragimov's method.

  19. Support for the 2001 Gordon Research Conference on the Origins of Solar Systems

    NASA Astrophysics Data System (ADS)

    Stevenson, David J.

    2002-01-01

    This grant provided partial support for participants at the Gordon Research Conference on Origins of Solar Systems, held at Connecticut College, June 17 through June 22, 2001. This conference was chaired by the PI (David Stevenson) and Pat Cassell (NASA Ames) was Vice-Chair. In addition to the money provided by this grant (15,000), the Gordon Research Conference organization provided about 22,000 (in large part from registration fees) and BPI provided 10,000 (through Director David Black); the latter targeted primarily for students and postdocs. Accordingly the grant money from NASA was used to cover the costs of registration and travel for about one half of the invited speakers (22 in total) and discussion leaders (about 10 in total).

  20. Collective coordinate approximation to the scattering of solitons in modified NLS and sine-Gordon models

    NASA Astrophysics Data System (ADS)

    Baron, H. E.; Zakrzewski, W. J.

    2016-06-01

    We investigate the validity of collective coordinate approximations to the scattering of two solitons in several classes of (1+1) dimensional field theory models. We consider models which are deformations of the sine-Gordon (SG) or the nonlinear Schrödinger (NLS) model which posses soliton solutions (which are topological (SG) or non-topological (NLS)). Our deformations preserve their topology (SG), but change their integrability properties, either completely or partially (models become `quasi-integrable').

  1. Logical inference approach to relativistic quantum mechanics: Derivation of the Klein-Gordon equation

    NASA Astrophysics Data System (ADS)

    Donker, H. C.; Katsnelson, M. I.; De Raedt, H.; Michielsen, K.

    2016-09-01

    The logical inference approach to quantum theory, proposed earlier De Raedt et al. (2014), is considered in a relativistic setting. It is shown that the Klein-Gordon equation for a massive, charged, and spinless particle derives from the combination of the requirements that the space-time data collected by probing the particle is obtained from the most robust experiment and that on average, the classical relativistic equation of motion of a particle holds.

  2. Snakes in the wrong places: Gordon Rodda’s career in invasive species research

    USGS Publications Warehouse

    Wilson, Jim

    2012-01-01

    When USGS research zoologist Gordon G. Rodda was a graduate student at Cornell University studying behavioral biology of alligators —or later, completing a post-doc at the Smithsonian Institute studying the social behavior of green iguanas in Venezuela or following that, as a statistics and sociobiology instructor at the University of Tennessee—he did not foresee that his professional future was in snakes. Lots of snakes, and in places they don’t belong.

  3. Solutions of the Klein-Gordon equation with the improved Rosen-Morse potential energy model

    NASA Astrophysics Data System (ADS)

    Chen, Tao; Lin, Shu-Rong; Jia, Chun-Sheng

    2013-07-01

    We solve the Klein-Gordon equation with the improved Rosen-Morse empirical potential energy model. The bound-state energy equation has been obtained by using the supersymmetric shape invariance approach. The relativistic vibrational transition frequencies for the 33Σg+ state of the Cs2 molecule have been computed by using the improved Rosen-Morse potential model. The relativistic vibrational transition frequencies are in good agreement with the experimental RKR values and DPF values.

  4. New records of the striped cleaner shrimp Lysmata grabhami (Gordon, 1935) from Brazil, Southwestern Atlantic.

    PubMed

    Kassuga, A D; Diele, K; Hostim-Silva, M

    2015-11-01

    New records for Lysmata grabhami (Gordon, 1935) in Brazilian waters are presented. Four adult individuals from coastal waters off the city of Vitória, Espírito Santo coast and one adult from Trindade Island were collected during scuba diving in depths between 20-40 meters. These two records represent the southernmost published finding of this species in the Atlantic and the record for Vitória, Espirito Santo is the first from Brazilian coastal waters. PMID:26675910

  5. Generalized Klein-Gordon and Dirac Equations from Nonlocal Kinetic Approach

    NASA Astrophysics Data System (ADS)

    El-Nabulsi, Rami Ahmad

    2016-09-01

    In this note, I generalized the Klein-Gordon and the Dirac equations by using Suykens's nonlocal-in-time kinetic energy approach, which is motivated from Feynman's kinetic energy functional formalism where the position differences are shifted with respect to one another. I proved that these generalized equations are similar to those obtained in literature in the presence of minimal length based on the Quesne-Tkachuk algebra.

  6. Klein-Gordon equations for energy-momentum of the relativistic particle in rapidity space

    SciTech Connect

    Yamaleev, R. M.

    2013-10-15

    The notion of four-rapidity is defined as a four-vector with one time-like and three space-like coordinates. It is proved, the energy and momentum defined in the space of four-rapidity obey Klein-Gordon equations constrained by the classical trajectory of a relativistic particle. It is shown, for small values of a proper mass influence of the constraint is weakened and the classical motion gains features of a wave motion.

  7. Dressing method for the vector sine-Gordon equation and its soliton interactions

    NASA Astrophysics Data System (ADS)

    Mikhailov, Alexander V.; Papamikos, Georgios; Wang, Jing Ping

    2016-06-01

    In this paper, we develop the dressing method to study the exact solutions for the vector sine-Gordon equation. The explicit formulas for one kink and one breather are derived. The method can be used to construct multi-soliton solutions. Two soliton interactions are also studied. The formulas for position shift of the kink and position and phase shifts of the breather are given. These quantities only depend on the pole positions of the dressing matrices.

  8. On the solution of the generalized wave and generalized sine-Gordon equations

    NASA Technical Reports Server (NTRS)

    Ablowitz, M. J.; Beals, R.; Tenenblat, K.

    1986-01-01

    The generalized wave equation and generalized sine-Gordon equations are known to be natural multidimensional differential geometric generalizations of the classical two-dimensional versions. In this paper, a system of linear differential equations is associated with these equations, and it is shown how the direct and inverse problems can be solved for appropriately decaying data on suitable lines. An initial-boundary value problem is solved for these equations.

  9. New records of the striped cleaner shrimp Lysmata grabhami (Gordon, 1935) from Brazil, Southwestern Atlantic.

    PubMed

    Kassuga, A D; Diele, K; Hostim-Silva, M

    2015-11-01

    New records for Lysmata grabhami (Gordon, 1935) in Brazilian waters are presented. Four adult individuals from coastal waters off the city of Vitória, Espírito Santo coast and one adult from Trindade Island were collected during scuba diving in depths between 20-40 meters. These two records represent the southernmost published finding of this species in the Atlantic and the record for Vitória, Espirito Santo is the first from Brazilian coastal waters.

  10. Interconnection between static regimes in the LJJs described by the double sine-Gordon equation

    NASA Astrophysics Data System (ADS)

    Atanasova, P. Kh; Zemlyanaya, E. V.; Shukrinov, Yu M.

    2012-11-01

    The second harmonic contribution to the current-phase relation changes the properties of the static magnetic flux distributions in the long Josephson junction (LJJ) and inspires new homogenious and fluxon static states. We study stability properties and bifurcations of these static regimes within the frame of a model described by the double sine-Gordon equation. The critical curves behavior and the interconnection between different types of magnetic flux distributions are analyzed.

  11. 2003 Partial Support of the Photoions:Photoionization and Photodetachment Gordon Research Conference

    SciTech Connect

    John HD Eland

    2004-11-01

    The Gordon Research Conference (GRC) on 2004 Gordon Research Conference on Biopolymers was held at Queen's College, Oxford, United Kingdom on 9/21-26/2003. The Conference was well-attended with 57 participants (attendees list attached). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. Attached is a copy of the formal schedule and speaker program and the poster program. In addition to these formal interactions, ''free time'' was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field. I want to personally thank you for your support of this Conference. As you know, in the interest of promoting the presentation of unpublished and frontier-breaking research, Gordon Research Conferences does not permit publication of meeting proceedings. If you wish any further details, please feel free to contact me. Thank you, Dr. John HD. Eland, 2003 Conference Chair.

  12. The Einstein-Klein-Gordon Equations, Wave Dark Matter, and the Tully-Fisher Relation

    NASA Astrophysics Data System (ADS)

    Goetz, Andrew S.

    2015-01-01

    We examine the Einstein equation coupled to the Klein-Gordon equation for a complex-valued scalar field. These two equations together are known as the Einstein-Klein-Gordon system. In the low-field, non-relativistic limit, the Einstein-Klein-Gordon system reduces to the Poisson-Schrodinger system. We describe the simplest solutions of these systems in spherical symmetry, the spherically symmetric static states, and some scaling properties they obey. We also describe some approximate analytic solutions for these states. The EKG system underlies a theory of wave dark matter, also known as scalar field dark matter (SFDM), boson star dark matter, and Bose-Einstein condensate (BEC) dark matter. We discuss a possible connection between the theory of wave dark matter and the baryonic Tully-Fisher relation, which is a scaling relation observed to hold for disk galaxies in the universe across many decades in mass. We show how fixing boundary conditions at the edge of the spherically symmetric static states implies Tully-Fisher-like relations for the states. We also catalog other ``scaling conditions'' one can impose on the static states and show that they do not lead to Tully-Fisher-like relations--barring one exception which is already known and which has nothing to do with the specifics of wave dark matter.

  13. Wave operators to a quadratic nonlinear Klein-Gordon equation in two space dimensions revisited

    NASA Astrophysics Data System (ADS)

    Hayashi, Nakao; Naumkin, Pavel I.; Tonegawa, Satoshi

    2012-08-01

    We continue to study the existence of the wave operators for the nonlinear Klein-Gordon equation with quadratic nonlinearity in two space dimensions {(partialt2-Δ+m2) u=λ u2,( t,x) in{R}×{R}2}. We prove that if u1+in{H}^{3/2+3γ,1}( {R}2),{ }u2+in{H}^{1/2+3γ,1}( {R} 2), where {γin( 0,1/4)} and the norm {Vert u1+Vert_{{H}1^{3/2+γ}}+Vert u2+Vert_{{H}1^{1/2+γ}}≤ρ,} then there exist ρ > 0 and T > 1 such that the nonlinear Klein-Gordon equation has a unique global solution {uin{C}( [ T,infty) ;{H}^{1/2}( {R}2) ) } satisfying the asymptotics Vert u( t) -u0 ( t) Vert _{{H}^{1/2}} ≤ Ct^{-1/2-γ} for all t > T, where u 0 denotes the solution of the free Klein-Gordon equation.

  14. The AAA+ proteins Pontin and Reptin enter adult age: from understanding their basic biology to the identification of selective inhibitors.

    PubMed

    Matias, Pedro M; Baek, Sung Hee; Bandeiras, Tiago M; Dutta, Anindya; Houry, Walid A; Llorca, Oscar; Rosenbaum, Jean

    2015-01-01

    Pontin and Reptin are related partner proteins belonging to the AAA+ (ATPases Associated with various cellular Activities) family. They are implicated in multiple and seemingly unrelated processes encompassing the regulation of gene transcription, the remodeling of chromatin, DNA damage sensing and repair, and the assembly of protein and ribonucleoprotein complexes, among others. The 2nd International Workshop on Pontin and Reptin took place at the Instituto de Tecnologia Química e Biológica António Xavier in Oeiras, Portugal on October 10-12, 2014, and reported significant new advances on the mechanisms of action of these two AAA+ ATPases. The major points under discussion were related to the mechanisms through which these proteins regulate gene transcription, their roles as co-chaperones, and their involvement in pathophysiology, especially in cancer and ciliary biology and disease. Finally, they may become anticancer drug targets since small chemical inhibitors were shown to produce anti-tumor effects in animal models.

  15. The AAA+ ATPase ATAD3A Controls Mitochondrial Dynamics at the Interface of the Inner and Outer Membranes ▿

    PubMed Central

    Gilquin, Benoît; Taillebourg, Emmanuel; Cherradi, Nadia; Hubstenberger, Arnaud; Gay, Olivia; Merle, Nicolas; Assard, Nicole; Fauvarque, Marie-Odile; Tomohiro, Shiho; Kuge, Osamu; Baudier, Jacques

    2010-01-01

    Dynamic interactions between components of the outer (OM) and inner (IM) membranes control a number of critical mitochondrial functions such as channeling of metabolites and coordinated fission and fusion. We identify here the mitochondrial AAA+ ATPase protein ATAD3A specific to multicellular eukaryotes as a participant in these interactions. The N-terminal domain interacts with the OM. A central transmembrane segment (TMS) anchors the protein in the IM and positions the C-terminal AAA+ ATPase domain in the matrix. Invalidation studies in Drosophila and in a human steroidogenic cell line showed that ATAD3A is required for normal cell growth and cholesterol channeling at contact sites. Using dominant-negative mutants, including a defective ATP-binding mutant and a truncated 50-amino-acid N-terminus mutant, we showed that ATAD3A regulates dynamic interactions between the mitochondrial OM and IM sensed by the cell fission machinery. The capacity of ATAD3A to impact essential mitochondrial functions and organization suggests that it possesses unique properties in regulating mitochondrial dynamics and cellular functions in multicellular organisms. PMID:20154147

  16. Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study.

    PubMed

    Huang, Rui; Ripstein, Zev A; Augustyniak, Rafal; Lazniewski, Michal; Ginalski, Krzysztof; Kay, Lewis E; Rubinstein, John L

    2016-07-19

    The AAA+ (ATPases associated with a variety of cellular activities) enzymes play critical roles in a variety of homeostatic processes in all kingdoms of life. Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), the archaeal homolog of the ubiquitous AAA+ protein Cdc48/p97, functions in concert with the 20S proteasome by unfolding substrates and passing them on for degradation. Here, we present electron cryomicroscopy (cryo-EM) maps showing that VAT undergoes large conformational rearrangements during its ATP hydrolysis cycle that differ dramatically from the conformational states observed for Cdc48/p97. We validate key features of the model with biochemical and solution methyl-transverse relaxation optimized spectroscopY (TROSY) NMR experiments and suggest a mechanism for coupling the energy of nucleotide hydrolysis to substrate unfolding. These findings illustrate the unique complementarity between cryo-EM and solution NMR for studies of molecular machines, showing that the structural properties of VAT, as well as the population distributions of conformers, are similar in the frozen specimens used for cryo-EM and in the solution phase where NMR spectra are recorded.

  17. From AAA to Acuros XB-clinical implications of selecting either Acuros XB dose-to-water or dose-to-medium.

    PubMed

    Zifodya, Jackson M; Challens, Cameron H C; Hsieh, Wen-Long

    2016-06-01

    When implementing Acuros XB (AXB) as a substitute for anisotropic analytic algorithm (AAA) in the Eclipse Treatment Planning System, one is faced with a dilemma of reporting either dose to medium, AXB-Dm or dose to water, AXB-Dw. To assist with decision making on selecting either AXB-Dm or AXB-Dw for dose reporting, a retrospective study of treated patients for head & neck (H&N), prostate, breast and lung is presented. Ten patients, previously treated using AAA plans, were selected for each site and re-planned with AXB-Dm and AXB-Dw. Re-planning was done with fixed monitor units (MU) as well as non-fixed MUs. Dose volume histograms (DVH) of targets and organs at risk (OAR), were analyzed in conjunction with ICRU-83 recommended dose reporting metrics. Additionally, comparisons of plan homogeneity indices (HI) and MUs were done to further highlight the differences between the algorithms. Results showed that, on average AAA overestimated dose to the target volume and OARs by less than 2.0 %. Comparisons between AXB-Dw and AXB-Dm, for all sites, also showed overall dose differences to be small (<1.5 %). However, in non-water biological media, dose differences between AXB-Dw and AXB-Dm, as large as 4.6 % were observed. AXB-Dw also tended to have unexpectedly high 3D maximum dose values (>135 % of prescription dose) for target volumes with high density materials. Homogeneity indices showed that AAA planning and optimization templates would need to be adjusted only for the H&N and Lung sites. MU comparison showed insignificant differences between AXB-Dw relative to AAA and between AXB-Dw relative to AXB-Dm. However AXB-Dm MUs relative to AAA, showed an average difference of about 1.3 % signifying an underdosage by AAA. In conclusion, when dose is reported as AXB-Dw, the effect that high density structures in the PTV has on the dose distribution should be carefully considered. As the results show overall small dose differences between the algorithms, when

  18. From AAA to Acuros XB-clinical implications of selecting either Acuros XB dose-to-water or dose-to-medium.

    PubMed

    Zifodya, Jackson M; Challens, Cameron H C; Hsieh, Wen-Long

    2016-06-01

    When implementing Acuros XB (AXB) as a substitute for anisotropic analytic algorithm (AAA) in the Eclipse Treatment Planning System, one is faced with a dilemma of reporting either dose to medium, AXB-Dm or dose to water, AXB-Dw. To assist with decision making on selecting either AXB-Dm or AXB-Dw for dose reporting, a retrospective study of treated patients for head & neck (H&N), prostate, breast and lung is presented. Ten patients, previously treated using AAA plans, were selected for each site and re-planned with AXB-Dm and AXB-Dw. Re-planning was done with fixed monitor units (MU) as well as non-fixed MUs. Dose volume histograms (DVH) of targets and organs at risk (OAR), were analyzed in conjunction with ICRU-83 recommended dose reporting metrics. Additionally, comparisons of plan homogeneity indices (HI) and MUs were done to further highlight the differences between the algorithms. Results showed that, on average AAA overestimated dose to the target volume and OARs by less than 2.0 %. Comparisons between AXB-Dw and AXB-Dm, for all sites, also showed overall dose differences to be small (<1.5 %). However, in non-water biological media, dose differences between AXB-Dw and AXB-Dm, as large as 4.6 % were observed. AXB-Dw also tended to have unexpectedly high 3D maximum dose values (>135 % of prescription dose) for target volumes with high density materials. Homogeneity indices showed that AAA planning and optimization templates would need to be adjusted only for the H&N and Lung sites. MU comparison showed insignificant differences between AXB-Dw relative to AAA and between AXB-Dw relative to AXB-Dm. However AXB-Dm MUs relative to AAA, showed an average difference of about 1.3 % signifying an underdosage by AAA. In conclusion, when dose is reported as AXB-Dw, the effect that high density structures in the PTV has on the dose distribution should be carefully considered. As the results show overall small dose differences between the algorithms, when

  19. SU-E-T-137: Dosimetric Validation for Pinnacle, Acuros, AAA, and Brainlab Algorithms with Induced Inhomogenieties

    SciTech Connect

    Lopez, P; Tambasco, M; LaFontaine, R; Burns, L

    2014-06-01

    Purpose: To compare the dosimetric accuracy of the Eclipse 11.0 Acuros XB and Anisotropic Analytical Algorithm (AAA), Pinnacle-3 9.2 Collapsed Cone Convolution, and the iPlan 4.1 Monte Carlo (MC) and Pencil Beam (PB) algorithms using measurement as the gold standard. Methods: Ion chamber and diode measurements were taken for 6, 10, and 18 MV beams in a phantom made up of slab densities corresponding to solid water, lung, and bone. The phantom was setup at source-to-surface distance of 100 cm, and the field sizes were 3.0 × 3.0, 5.0 × 5.0, and 10.0 × 10.0 cm2. Data from the planning systems were computed along the central axis of the beam. The measurements were taken using a pinpoint chamber and edge diode for interface regions. Results: The best agreement between data from the algorithms and our measurements occurs away from the slab interfaces. For the 6 MV beam, iPlan 4.1 MC software performs the best with 1.7% absolute average percent difference from measurement. For the 10 MV beam, iPlan 4.1 PB performs the best with 2.7% absolute average percent difference from measurement. For the 18 MV beam, Acuros performs the best with 2.0% absolute average percent difference from measurement. It is interesting to note that the steepest drop in dose occurred the at lung heterogeneity-solid water interface of the18 MV, 3.0 × 3.0 cm2 field size setup. In this situation, Acuros and AAA performed best with an average percent difference within −1.1% of measurement, followed by iPlan 4.1 MC, which was within 4.9%. Conclusion: This study shows that all of the algorithms perform reasonably well in computing dose in a heterogeneous slab phantom. Moreover, Acuros and AAA perform particularly well at the lung-solid water interfaces for higher energy beams and small field sizes.

  20. 'National Hero and Very Queer Fish': Empire, Sexuality and the British Remembrance of General Gordon, 1918-72.

    PubMed

    Jones, Max

    2015-01-01

    This article presents the first detailed study of General Gordon's remembrance in Britain between 1918 and 1972. Previous scholars have exaggerated the impact of Lytton Strachey's Eminent Victorians (1918). Strachey damaged Gordon's reputation, but part one reveals how several commentators forcefully rebutted Eminent Victorians; official commemorations, books, radio plays, and films celebrated Gordon in the 1930s, as empire featured prominently in mass culture. Didactic uses of his example by the state diminished after 1945, but parts 2 and 3 show how writers used Gordon's story to engage with new debates about Britain's role in the world, immigration and sexuality. The article reveals how a fascination with the sexuality of heroes inspired men as diverse as Viscount Robin Maugham and East End gangster Ronnie Kray to identify with Gordon. Maugham's works and the feature film Khartoum (1966) expressed nostalgia for empire during decolonization, but American screenwriter Robert Ardrey also drew on his experiences in the Congo to present a dark vision of African savagery in Khartoum, a vision performed at Pinewood studios by black immigrants from London's slums. The article questions Edward Berenson's emphasis on the 'charismatic aura' of heroes, emphasizing instead the diversity of engagements inspired through different genre.

  1. Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis

    PubMed Central

    Anderson, Daniel J.; Le Moigne, Ronan; Djakovic, Stevan; Kumar, Brajesh; Rice, Julie; Wong, Steve; Wang, Jinhai; Yao, Bing; Valle, Eduardo; von Soly, Szerenke Kiss; Madriaga, Antonett; Soriano, Ferdie; Menon, Mary-Kamala; Wu, Zhi Yong; Kampmann, Martin; Chen, Yuwen; Weissman, Jonathan S.; Aftab, Blake T.; Yakes, F. Michael; Shawver, Laura; Zhou, Han-Jie; Wustrow, David; Rolfe, Mark

    2016-01-01

    Summary p97 is a AAA-ATPase with multiple cellular functions, one of which is critical regulation of protein homeostasis pathways. We describe the characterization of CB-5083, a potent, selective and orally bioavailable inhibitor of p97. Treatment of tumor cells with CB-5083 leads to accumulation of poly-ubiquitinated proteins, retention of endoplasmic reticulum associated degradation (ERAD) substrates and generation of irresolvable proteotoxic stress leading to activation of the apoptotic arm of the unfolded protein response (UPR). In xenograft models, CB-5083 causes modulation of key p97-related pathways, induces apoptosis and has antitumor activity in a broad range of both hematological and solid tumor models. Molecular determinants of CB-5083 activity include expression of genes in the ERAD pathway providing a potential strategy for patient selection. PMID:26555175

  2. The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits

    PubMed Central

    Gardner, Brooke M.; Chowdhury, Saikat; Lander, Gabriel C.; Martin, Andreas

    2015-01-01

    Pex1 and Pex6 are Type-2 AAA+ ATPases required for the de-novo biogenesis of peroxisomes. Mutations in Pex1 and Pex6 account for the majority of the most severe forms of peroxisome biogenesis disorders in humans. Here we show that the ATP-dependent complex of Pex1 and Pex6 from S. cerevisiae is a heterohexamer with alternating subunits. Within the Pex1/Pex6 complex, only the D2 ATPase ring hydrolyzes ATP, while nucleotide binding in the D1 ring promotes complex assembly. ATP hydrolysis by Pex1 is highly coordinated with that of Pex6. Furthermore, Pex15, the membrane anchor required for Pex1/Pex6 recruitment to peroxisomes inhibits the ATP-hydrolysis activity of Pex1/Pex6. PMID:25659908

  3. The talent endoluminal AAA stent-graft system. Report of the phase I USA trial, and summary of worldwide experience.

    PubMed

    Criado, F J; Fry, P D; Machan, L S; Twena, M; Patten, P

    1998-12-01

    In the United States, the Phase I Feasibility Study under IDE G970065 was approved by the Food and Drug Administration on 04/11/97. The approved protocol called for implantation of the bifurcated Talent spring stent-graft system on patients who are high-risk candidates for conventional surgery because of cardio-respiratory, medical, general, or local anatomical reasons which would likely complicate the technical execution of the operation or be accompanied by a high expected mortality rate. Patient enrollment was complete with 16 cases as of September 26, 1997. This was a multicenter experience involving five different sites. This is an ongoing study and patients, of course, will continue to be followed longitudinally. Phase II will likely be approved by the FDA for initiation in January or February of 1998. Standard-risk AAA patients will be entered into the study at this time; comparison with concurrent controls will be used for comparison with conventional surgery. PMID:9894193

  4. Structural Characterization of a Newly Identified Component of α-Carboxysomes: The AAA+ Domain Protein CsoCbbQ

    SciTech Connect

    Sutter, Markus; Roberts, Evan W.; Gonzalez, Raul C.; Bates, Cassandra; Dawoud, Salma; Landry, Kimberly; Cannon, Gordon C.; Heinhorst, Sabine; Kerfeld, Cheryl A.

    2015-11-05

    Carboxysomes are bacterial microcompartments that enhance carbon fixation by concentrating ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and its substrate CO2 within a proteinaceous shell. They are found in all cyanobacteria, some purple photoautotrophs and many chemoautotrophic bacteria. Carboxysomes consist of a protein shell that encapsulates several hundred molecules of RuBisCO, and contain carbonic anhydrase and other accessory proteins. Genes coding for carboxysome shell components and the encapsulated proteins are typically found together in an operon. The α-carboxysome operon is embedded in a cluster of additional, conserved genes that are presumably related to its function. In many chemoautotrophs, products of the expanded carboxysome locus include CbbO and CbbQ, a member of the AAA+ domain superfamily. We bioinformatically identified subtypes of CbbQ proteins and show that their genes frequently co-occur with both Form IA and Form II RuBisCO. The α-carboxysome-associated ortholog, CsoCbbQ, from Halothiobacillus neapolitanus forms a hexamer in solution and hydrolyzes ATP. The crystal structure shows that CsoCbbQ is a hexamer of the typical AAA+ domain; the additional C-terminal domain, diagnostic of the CbbQ subfamily, structurally fills the inter-monomer gaps, resulting in a distinctly hexagonal shape. Finally, we show that CsoCbbQ interacts with CsoCbbO and is a component of the carboxysome shell, the first example of ATPase activity associated with a bacterial microcompartment.

  5. Structural Characterization of a Newly Identified Component of α-Carboxysomes: The AAA+ Domain Protein CsoCbbQ

    DOE PAGES

    Sutter, Markus; Roberts, Evan W.; Gonzalez, Raul C.; Bates, Cassandra; Dawoud, Salma; Landry, Kimberly; Cannon, Gordon C.; Heinhorst, Sabine; Kerfeld, Cheryl A.

    2015-11-05

    Carboxysomes are bacterial microcompartments that enhance carbon fixation by concentrating ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and its substrate CO2 within a proteinaceous shell. They are found in all cyanobacteria, some purple photoautotrophs and many chemoautotrophic bacteria. Carboxysomes consist of a protein shell that encapsulates several hundred molecules of RuBisCO, and contain carbonic anhydrase and other accessory proteins. Genes coding for carboxysome shell components and the encapsulated proteins are typically found together in an operon. The α-carboxysome operon is embedded in a cluster of additional, conserved genes that are presumably related to its function. In many chemoautotrophs, products of the expanded carboxysome locusmore » include CbbO and CbbQ, a member of the AAA+ domain superfamily. We bioinformatically identified subtypes of CbbQ proteins and show that their genes frequently co-occur with both Form IA and Form II RuBisCO. The α-carboxysome-associated ortholog, CsoCbbQ, from Halothiobacillus neapolitanus forms a hexamer in solution and hydrolyzes ATP. The crystal structure shows that CsoCbbQ is a hexamer of the typical AAA+ domain; the additional C-terminal domain, diagnostic of the CbbQ subfamily, structurally fills the inter-monomer gaps, resulting in a distinctly hexagonal shape. Finally, we show that CsoCbbQ interacts with CsoCbbO and is a component of the carboxysome shell, the first example of ATPase activity associated with a bacterial microcompartment.« less

  6. Structural Characterization of a Newly Identified Component of α-Carboxysomes: The AAA+ Domain Protein CsoCbbQ

    PubMed Central

    Sutter, Markus; Roberts, Evan W.; Gonzalez, Raul C.; Bates, Cassandra; Dawoud, Salma; Landry, Kimberly; Cannon, Gordon C.; Heinhorst, Sabine; Kerfeld, Cheryl A.

    2015-01-01

    Carboxysomes are bacterial microcompartments that enhance carbon fixation by concentrating ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and its substrate CO2 within a proteinaceous shell. They are found in all cyanobacteria, some purple photoautotrophs and many chemoautotrophic bacteria. Carboxysomes consist of a protein shell that encapsulates several hundred molecules of RuBisCO, and contain carbonic anhydrase and other accessory proteins. Genes coding for carboxysome shell components and the encapsulated proteins are typically found together in an operon. The α-carboxysome operon is embedded in a cluster of additional, conserved genes that are presumably related to its function. In many chemoautotrophs, products of the expanded carboxysome locus include CbbO and CbbQ, a member of the AAA+ domain superfamily. We bioinformatically identified subtypes of CbbQ proteins and show that their genes frequently co-occur with both Form IA and Form II RuBisCO. The α-carboxysome-associated ortholog, CsoCbbQ, from Halothiobacillus neapolitanus forms a hexamer in solution and hydrolyzes ATP. The crystal structure shows that CsoCbbQ is a hexamer of the typical AAA+ domain; the additional C-terminal domain, diagnostic of the CbbQ subfamily, structurally fills the inter-monomer gaps, resulting in a distinctly hexagonal shape. We show that CsoCbbQ interacts with CsoCbbO and is a component of the carboxysome shell, the first example of ATPase activity associated with a bacterial microcompartment. PMID:26538283

  7. In vitro propagation and assessment of the genetic fidelity of Musa acuminata (AAA) cv. Vaibalhla derived from immature male flowers.

    PubMed

    Hrahsel, Lalremsiami; Basu, Adreeja; Sahoo, Lingaraj; Thangjam, Robert

    2014-02-01

    An efficient in vitro propagation method has been developed for the first time for Musa acuminata (AAA) cv. Vaibalhla, an economically important banana cultivar of Mizoram, India. Immature male flowers were used as explants. Murashige and Skoog's (MS) medium supplemented with plant growth regulators (PGRs) were used for the regeneration process. Out of different PGR combinations, MS medium supplemented with 2 mg L(-1) 6-benzylaminopurine (BAP) + 0.5 mg L(-1) α-naphthalene acetic acid (NAA) was optimal for production of white bud-like structures (WBLS). On this medium, explants produced the highest number of buds per explant (4.30). The highest percentage (77.77) and number (3.51) of shoot formation from each explants was observed in MS medium supplemented with 2 mg L(-1) kinetin + 0.5 mg L(-1) NAA. While MS medium supplemented with a combination of 2 mg L(-1) BAP + 0.5 mg L(-1) NAA showed the maximum shoot length (14.44 cm). Rooting efficiency of the shoots was highest in the MS basal medium without any PGRs. The plantlets were hardened successfully in the greenhouse with 96% survival rate. Random amplified polymorphic DNA (RAPD) and inter-simple sequence repeat (ISSR) markers were employed to assess the genetic stability of in vitro regenerated plantlets of M. acuminata (AAA) cv. Vaibalhla. Eight RAPD and 8 ISSR primers were successfully used for the analysis from the 40 RAPD and 30 ISSR primers screened initially. The amplified products were monomorphic across all the regenerated plants and were similar to the mother plant. The present standardised protocol will find application in mass production, conservation and genetic transformation studies of this commercially important banana.

  8. Regularization of multi-soliton form factors in sine-Gordon model

    NASA Astrophysics Data System (ADS)

    Pálmai, T.

    2012-08-01

    A general and systematic regularization is developed for the exact solitonic form factors of exponential operators in the (1+1)-dimensional sine-Gordon model by analytical continuation of their integral representations. The procedure is implemented in Mathematica. Test results are shown for four- and six-soliton form factors. Catalogue identifier: AEMG_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEMG_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 1462 No. of bytes in distributed program, including test data, etc.: 15 488 Distribution format: tar.gz Programming language: Mathematica [1] Computer: PC Operating system: Cross-platform Classification: 7.7, 11.1, 23 Nature of problem: The multi-soliton form factors of the sine-Gordon model (relevant in two-dimensional physics) were given only by highly non-trivial integral representation with a limited domain of convergence. Practical applications of the form factors, e.g. calculation of correlation functions in two-dimensional condensed matter systems, were not possible in general. Solution method: Using analytic continuation techniques an efficient algorithm is found and implemented in Mathematica, which provides a general and systematic way to calculate multi-soliton form factors in the sine-Gordon model. The package contains routines to compute the two-, four- and six-soliton form factors. Running time: Strongly dependent on the desired accuracy and the number of solitons. For physical rapidities after an initialization of about 30 s, the calculation of the two-, four- and six-soliton form factors at a single point takes approximately 0.5 s, 2.5 s and 8 s, respectively. Wolfram Research, Inc., Mathematica Edition: Version 7.0, Wolfram Research, Inc., Champaign, Illinois, 2008.

  9. Stochastic D-bifurcation for a damped sine-Gordon equation with noise

    SciTech Connect

    Huang, Qiongwei; Xue, Changfeng; Tang, Jiashi

    2015-04-15

    We investigate the stochastic bifurcation of a damped sine-Gordon equation with Dirichlet boundary conditions under the influence of multiplicative Gaussian white noise. Introducing a slow time scale, we derive the amplitude equations near the trivial solution by multiscale analysis. And the stationary probability density functions are formulated analytically using the stochastic averaging of energy envelope. The numerical calculations show that the system undergoes a stochastic D-bifurcation of energy envelope from a delta measure to new stationary measures when the control parameter crosses a critical point.

  10. Quantum Creep and Quantum-Creep Transitions in 1D Sine-Gordon Chains.

    PubMed

    Krajewski, Florian R; Müser, Martin H

    2004-01-23

    Discrete sine-Gordon (SG) chains are studied with path-integral molecular dynamics. Chains commensurate with the substrate show the transition from pinning to quantum creep at bead masses slightly larger than in the continuous SG model. Within the creep regime, a field-driven transition from creep to complete depinning is identified. The effects of disorder on the chain's dynamics depend on the potential's roughness exponent H. For example, quantum fluctuations are generally too small to depin the chain if H=1/2, while an H=0 chain can be pinned or unpinned depending on the bead masses. Thermal fluctuations always depin the chain. PMID:14753858

  11. Oscillons and quasibreathers in the ϕ4 Klein-Gordon model

    NASA Astrophysics Data System (ADS)

    Fodor, Gyula; Forgács, Péter; Grandclément, Philippe; Rácz, István

    2006-12-01

    Strong numerical evidence is presented for the existence of a continuous family of time-periodic solutions with “weak” spatial localization of the spherically symmetric nonlinear Klein-Gordon equation in 3+1 dimensions. These solutions are “weakly” localized in space in that they have slowly decaying oscillatory tails and can be interpreted as localized standing waves (quasibreathers). By a detailed analysis of long-lived metastable states (oscillons) formed during the time evolution, it is demonstrated that the oscillon states can be quantitatively described by the weakly localized quasibreathers. It is found that the quasibreathers and their oscillon counterparts exist for a whole continuum of frequencies.

  12. 2013 GASEOUS IONS GORDON RESEARCH CONFERENCE, FEBRUARY 24 - MARCH 1, 2013

    SciTech Connect

    Williams, Evan

    2013-03-01

    The Gaseous Ions: Structures, Energetics and Reactions Gordon Research Conference will focus on ions and their interactions with molecules, surfaces, electrons, and light. The long-standing goal of our community is to develop new strategies for capturing complex molecular architectures as gas phase ions where they can be isolated, characterized and manipulated with great sensitivity. Emergent areas of interest include catalytic mechanisms, cryogenic processing of ions extracted from solution, ion fragmentation mechanisms, and new methods for ion formation and structural characterization. The conference will cover theoretical and experimental advances on systems ranging from model studies at the molecular scale to preparation of nanomaterials and characterization of large biological molecules.

  13. A five-dimensional perspective on the Klein–Gordon equation

    SciTech Connect

    Breban, Romulus

    2015-05-15

    We discuss the Klein–Gordon (KG) equation using a path-integral approach in 5D space–time. We explicitly show that the KG equation in flat space–time admits a consistent probabilistic interpretation with positively defined probability density. However, the probabilistic interpretation is not covariant. In the non-relativistic limit, the formalism reduces naturally to that of the Schrödinger equation. We further discuss other interpretations of the KG equation (and their non-relativistic limits) resulting from the 5D space–time picture. Finally, we apply our results to the problem of hydrogenic spectra and calculate the canonical sum of the hydrogenic atom.

  14. Mass of the sine-Gordon soliton in the Hartree approximation

    NASA Astrophysics Data System (ADS)

    Altenbokum, M.; Kaulfuss, U.; Verbaarschot, J. J. M.

    1986-09-01

    We derive the quantum corrections to the mass of the one-soliton solution of the sine-Gordon system in the Hartree approximation. In the weak-coupling limit we reproduce the semiclassical correction to the soliton mass. This happens only after a nontrivial cancellation of contributions related to the deformation of the soliton due to quantum fluctuations. Numerical results are obtained up to the critical value of the coupling constant as given by Coleman. In approaching the critical point we find an increasing number of discrete modes which seem to build up a new continuum with a lower mass.

  15. 2001 Gordon Research Conference on Organometallic Chemistry. Final progress report [agenda and attendee list

    SciTech Connect

    Burns, Carol

    2001-07-27

    The Gordon Research Conference on Organometallic Chemistry was held at Salve Regina University, Newport, Rhode Island, July 22-27, 2001. The conference had 133 participants. The attendees represented the spectrum of endeavor in this field, coming from academia, industry, and government laboratories, and included US and foreign scientists, senior researchers, young investigators, and students. Emphasis was place on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions; poster sessions were held.

  16. To evolve an ear: Epistemological implications of Gordon Pask`s electrochemical devices

    SciTech Connect

    Cariani, P.

    1993-12-31

    In the late 1950`s Gordon Pask constructed several electrochemical devices having emergent sensory capabilities. These control systems possessed the ability to adaptively construct their own sensors, thereby choosing the relationship between their internal states and the world at large. Devices were built that evolved de novo sensitivity to sound or magnetic fields. Pask`s devices have far-reaching implications for artificial intelligence, self-constructing devices, theories of observers and epistemically-autonomous agents, theories of functional emergence, machine creativity, and the limits of contemporary machine learning paradigms. 44 refs.

  17. Chaos in a model of the forced and damped Sine-Gordon equation

    SciTech Connect

    Kovacic, G.

    1990-01-01

    The author analytically determines two of the mechanisms which cause chaotic dynamics to appear in a model of the forced and damped Sine Gordon equation. In particular, he finds orbits homoclinic to periodic orbits, and orbits homoclinic to fixed points which satisfy conditions sufficient to guarantee the existence of nearby chaotic invariant sets. One of these homoclinic orbits is a so-called Silnikov-type loop. A proof the existence of a symmetric pair of such loops is the main result. This proof consists of a modified Melnikov perturbation analysis, augmented by some techniques from the field of geometric singular perturbation theory.

  18. Stochastic variational method as quantization scheme: Field quantization of the complex Klein-Gordon equation

    NASA Astrophysics Data System (ADS)

    Koide, T.; Kodama, T.

    2015-09-01

    The stochastic variational method (SVM) is the generalization of the variational approach to systems described by stochastic variables. In this paper, we investigate the applicability of SVM as an alternative field-quantization scheme, by considering the complex Klein-Gordon equation. There, the Euler-Lagrangian equation for the stochastic field variables leads to the functional Schrödinger equation, which can be interpreted as the Euler (ideal fluid) equation in the functional space. The present formulation is a quantization scheme based on commutable variables, so that there appears no ambiguity associated with the ordering of operators, e.g., in the definition of Noether charges.

  19. Nonperturbative study of the two-frequency sine-Gordon model

    NASA Astrophysics Data System (ADS)

    Bajnok, Z.; Palla, L.; Takács, G.; Wágner, F.

    2001-05-01

    The two-frequency sine-Gordon model is examined. The focus is mainly on the case when the ratio of the frequencies is 1/2, given the recent interest in the literature. We discuss the model both in a perturbative (form factor perturbation theory) and a nonperturbative (truncated conformal space approach) framework, and give particular attention to a phase transition conjectured earlier by Delfino and Mussardo. We give substantial evidence that the transition is of second order and that it is in the Ising universality class. Furthermore, we check the UV-IR operator correspondence and conjecture the phase diagram of the theory.

  20. Nonperturbative Analysis of the Two-Frequency Sine-Gordon Model

    NASA Astrophysics Data System (ADS)

    Bajnok, Z.; Palla, L.; Takács, G.; Wágner, F.

    2001-04-01

    The two-frequency sine-Gordon model is examined. The focus is mainly on the case when the ratio of the frequencies is 1/2, given the recent interest in the literature. We discuss the model both in a perturbative (form factor perturbation theory) and a nonperturbative (truncated conformal space approach) framework, and give particular attention to a phase transition conjectured earlier by Delfino and Mussardo. We give substantial evidence that the transition is of second order and that it is in the Ising universality class. Furthermore, we check the UV-IR operator correspondence and conjecture the phase diagram of the theory.

  1. Dispersion relation of the nonlinear Klein-Gordon equation through a variational method.

    PubMed

    Amore, Paolo; Raya, Alfredo

    2006-03-01

    We derive approximate expressions for the dispersion relation of the nonlinear Klein-Gordon equation in the case of strong nonlinearities using a method based on the linear delta expansion. All the results obtained in this article are fully analytical, never involve the use of special functions, and can be used to obtain systematic approximations to the exact results to any desired degree of accuracy. We compare our findings with similar results in the literature and show that our approach leads to better and simpler results.

  2. Exact Mass-Coupling Relation for the Homogeneous Sine-Gordon Model

    NASA Astrophysics Data System (ADS)

    Bajnok, Zoltán; Balog, János; Ito, Katsushi; Satoh, Yuji; Tóth, Gábor Zsolt

    2016-05-01

    We derive the exact mass-coupling relation of the simplest multiscale quantum integrable model, i.e., the homogeneous sine-Gordon model with two mass scales. The relation is obtained by comparing the perturbed conformal field theory description of the model valid at short distances to the large distance bootstrap description based on the model's integrability. In particular, we find a differential equation for the relation by constructing conserved tensor currents, which satisfy a generalization of the Θ sum rule Ward identity. The mass-coupling relation is written in terms of hypergeometric functions.

  3. Dispersion estimates for one-dimensional Schrödinger and Klein-Gordon equations revisited

    NASA Astrophysics Data System (ADS)

    Egorova, I. E.; Kopylova, E. A.; Marchenko, V. A.; Teschl, G.

    2016-06-01

    It is shown that for a one-dimensional Schrödinger operator with a potential whose first moment is integrable the elements of the scattering matrix are in the unital Wiener algebra of functions with integrable Fourier transforms. This is then used to derive dispersion estimates for solutions of the associated Schrödinger and Klein-Gordon equations. In particular, the additional decay conditions are removed in the case where a resonance is present at the edge of the continuous spectrum. Bibliography: 29 titles.

  4. On the properties of the Volkov solutions of the Klein-Gordon equation

    NASA Astrophysics Data System (ADS)

    Boca, Madalina

    2011-11-01

    We present an elementary proof based on a direct calculation of the property of completeness at constant time of the solutions of the Klein-Gordon equation for a charged particle in a plane wave electromagnetic field. We also review different forms of the orthogonality and completeness relations previously presented in the literature and discuss the possibility of constructing the Feynman propagator for the particle in a plane-wave laser pulse as an expansion in terms of Volkov solutions. We show that this leads to a rigorous justification for the expression of the transition amplitude, currently used in the literature, for a class of laser-assisted or laser-induced processes.

  5. Relativistic superfluidity and vorticity from the nonlinear Klein-Gordon equation

    NASA Astrophysics Data System (ADS)

    Xiong, Chi; Good, Michael R. R.; Guo, Yulong; Liu, Xiaopei; Huang, Kerson

    2014-12-01

    We investigate superfluidity, and the mechanism for creation of quantized vortices, in the relativistic regime. The general framework is a nonlinear Klein-Gordon equation in curved spacetime for a complex scalar field, whose phase dynamics gives rise to superfluidity. The mechanisms discussed are local inertial forces (Coriolis and centrifugal), and current-current interaction with an external source. The primary application is to cosmology, but we also discuss the reduction to the nonrelativistic nonlinear Schrödinger equation, which is widely used in describing superfluidity and vorticity in liquid helium and cold-trapped atomic gases.

  6. The Klein-Gordon equation on the toric AdS-Schwarzschild black hole

    NASA Astrophysics Data System (ADS)

    Dunn, Jake; Warnick, Claude

    2016-06-01

    We consider the Klein-Gordon equation on the exterior of the toric anti de-Sitter Schwarzschild black hole with Dirichlet, Neumann and Robin boundary conditions at { I }. We define a non-degenerate energy for the equation which controls the renormalised H 1 norm of the field. We then establish both decay and integrated decay of this energy through vector field methods. Finally, we demonstrate the necessity of ‘losing a derivative’ in the integrated energy estimate through the construction of a Gaussian beam staying in the exterior of the event horizon for arbitrarily long coordinate time.

  7. Analytical solution of the Klein Gordon equation for a quadratic exponential-type potential

    NASA Astrophysics Data System (ADS)

    Ezzatpour, Somayyeh; Akbarieh, Amin Rezaei

    2016-07-01

    In this research study, analytical solutions of the Klein Gordon equation by considering the potential as a quadratic exponential will be presented. However, the potential is assumed to be within the framework of an approximation for the centrifugal potential in any state. The Nikiforov-Uvarov method is used to calculate the wave function, as well as corresponding exact energy equation, in bound states. We finally concluded that the quadratic exponential-type potential under which the results were deduced, led to outcomes that were comparable to the results obtained from the well-known potentials in some special cases.

  8. A note on soliton solutions of Klein-Gordon-Zakharov equation by variational approach

    NASA Astrophysics Data System (ADS)

    Khan, Najeeb Alam; Riaz, Fatima; Ara, Asmat

    2016-09-01

    In this paper, an investigation has been made to validate the variational approach to obtain soliton solutions of the Klein-Gordon-Zakharov (KGZ) equations. It is evident that to resolve the non-linear partial differential equations are quite complex and difficult. The presented approach is capable of achieving the condition for continuation of the solitary solution of KGZ equation as well as the initial solutions selected in soliton form including various unknown parameters can be resolute in the solution course of action. The procedure of attaining the solution reveals that the scheme is simple and straightforward.

  9. Breaking integrability at the boundary: the sine-Gordon model with Robin boundary conditions

    NASA Astrophysics Data System (ADS)

    Arthur, Robert; Dorey, Patrick; Parini, Robert

    2016-04-01

    We explore boundary scattering in the sine-Gordon model with a non-integrable family of Robin boundary conditions. The soliton content of the field after collision is analysed using a numerical implementation of the direct scattering problem associated with the inverse scattering method. We find that an antikink may be reflected into various combinations of an antikink, a kink, and one or more breathers, depending on the values of the initial antikink velocity and a parameter associated with the boundary condition. In addition we observe regions with an intricate resonance structure arising from the creation of an intermediate breather whose recollision with the boundary is highly dependent on the breather phase.

  10. First Order Solutions for Klein-Gordon-Maxwell Equations in a Specific Curved Manifold Case

    SciTech Connect

    Murariu, Gabriel

    2009-05-22

    The aim of this paper is to study the SO(3,1)xU(1) gauge minimally coupled charged spinless field to a spherically symmetric curved space-time. It is derived the first order analytically approximation solution for the system of Klein-Gordon-Maxwell equations. Using these solutions, it evaluated the system electric charge density. The considered space -time manifold generalize an anterior studied one. The chosen space time configuration is of S diagonal type from the MAPLE GRTensor II metrics package.

  11. Helping the helpers around the world: an interview with James S. Gordon, MD. Interview by Lewis, Sheldon.

    PubMed

    Gordon, James S

    2007-01-01

    James S. Gordon, MD, is the founder and director of The Center for Mind-Body Medicine in Washington, DC. A graduate of Harvard Medical School, Dr Gordon is a clinical professor in the departments of Psychiatry and Family Medicine at the Georgetown University School of Medicine and the former Chairman of the White House Commission on Complementary and Alternative Medicine Policy. For 10 years, Dr Gordon was a research psychiatrist at the National Institute of Mental Health, where he developed the first national program for runaway and homeless youth, directed the Special Study on Alternative Services for President Carter's Commission on Mental Health, and created a nationwide preceptorship program for medical students. At The Center for Mind-Body Medicine, Dr Gordon created a mind-body skills program for physicians, medical students, and other healthcare professionals and for people with cancer, depression, and other chronic illnesses. Through the Center's Healing the Wounds of War initiative, he has brought these programs around the world to populations in crisis in Kosovo, Gaza, Israel, Macedonia, Bosnia, New York City following 9/11, and more recently to the Gulf Coast following Hurricane Katrina. Dr Gordon is the author of Manifesto for a New Medicine (Perseus, 1996), Comprehensive Cancer Care (Perseus, 2000), and the forthcoming Unstuck: Your Guide to the Seven Stage Journey Out of Depression (Penguin, June 2008). In November, Dr Gordon was honored as one of the Pioneers of Integrative Medicine by the Bravewell Collaborative. Recently, he spoke with Advances editor in chief Sheldon Lewis, who participated in the Professional Training Program in Mind-Body Medicine in New Orleans in September. PMID:20664129

  12. Nonlinear instabilities of multi-site breathers in Klein-Gordon lattices

    SciTech Connect

    Cuevas-Maraver, Jesus; Kevrekidis, Panayotis G.; Pelinovsky, Dmitry E.

    2015-12-14

    Here, we explore the possibility of multi-site breather states in a nonlinear Klein–Gordon lattice to become nonlinearly unstable, even if they are found to be spectrally stable. The mechanism for this nonlinear instability is through the resonance with the wave continuum of a multiple of an internal mode eigenfrequency in the linearization of excited breather states. For the nonlinear instability, the internal mode must have its Krein signature opposite to that of the wave continuum. This mechanism is not only theoretically proposed, but also numerically corroborated through two concrete examples of the Klein–Gordon lattice with a soft (Morse) and a hard (Φ4) potential. Compared to the case of the nonlinear Schrödinger lattice, the Krein signature of the internal mode relative to that of the wave continuum may change depending on the period of the multi-site breather state. For the periods for which the Krein signatures of the internal mode and the wave continuum coincide, multi-site breather states are observed to be nonlinearly stable.

  13. Nonlinear instabilities of multi-site breathers in Klein-Gordon lattices

    DOE PAGES

    Cuevas-Maraver, Jesus; Kevrekidis, Panayotis G.; Pelinovsky, Dmitry E.

    2015-12-14

    Here, we explore the possibility of multi-site breather states in a nonlinear Klein–Gordon lattice to become nonlinearly unstable, even if they are found to be spectrally stable. The mechanism for this nonlinear instability is through the resonance with the wave continuum of a multiple of an internal mode eigenfrequency in the linearization of excited breather states. For the nonlinear instability, the internal mode must have its Krein signature opposite to that of the wave continuum. This mechanism is not only theoretically proposed, but also numerically corroborated through two concrete examples of the Klein–Gordon lattice with a soft (Morse) and amore » hard (Φ4) potential. Compared to the case of the nonlinear Schrödinger lattice, the Krein signature of the internal mode relative to that of the wave continuum may change depending on the period of the multi-site breather state. For the periods for which the Krein signatures of the internal mode and the wave continuum coincide, multi-site breather states are observed to be nonlinearly stable.« less

  14. Quantum sine-Gordon dynamics on analogue curved spacetime in a weakly imperfect scalar Bose gas

    NASA Astrophysics Data System (ADS)

    Volkoff, T. J.; Fischer, Uwe R.

    2016-07-01

    Using the coherent state functional integral expression of the partition function, we show that the sine-Gordon model on an analogue curved spacetime arises as the effective quantum field theory for phase fluctuations of a weakly imperfect Bose gas on an incompressible background superfluid flow when these fluctuations are restricted to a subspace of the single-particle Hilbert space. We consider bipartitions of the single-particle Hilbert space relevant to experiments on ultracold bosonic atomic or molecular gases, including, e.g., restriction to high- or low-energy sectors of the dynamics and spatial bipartition corresponding to tunnel-coupled planar Bose gases. By assuming full unitary quantum control in the low-energy subspace of a trapped gas, we show that (1) appropriately tuning the particle number statistics of the lowest-energy mode partially decouples the low- and high-energy sectors, allowing any low-energy single-particle wave function to define a background for sine-Gordon dynamics on curved spacetime and (2) macroscopic occupation of a quantum superposition of two states of the lowest two modes produces an analogue curved spacetime depending on two background flows, with respective weights continuously dependent on the corresponding weights of the superposed quantum states.

  15. 2005 Laser Diagnostics in Combustion Gordon Conference July 31-August 5, 2005

    SciTech Connect

    Mark G. Allen

    2005-08-01

    The Gordon Research Conference (GRC) on LASER DIAGNOSTICS IN COMBUSTION was held at Mount Holyoke College from 7/31/2005 thru 8/5/2005. The Conference was well-attended with 121 participants (attendees list attached). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. Attached is a copy of the formal schedule and speaker program and the poster program. In addition to these formal interactions, ''free time'' was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field. I want to personally thank you for your support of this Conference. As you know, in the interest of promoting the presentation of unpublished and frontier-breaking research, Gordon Research Conferences does not permit publication of meeting proceedings. If you wish any further details, please feel free to contact me.

  16. Quantum Singularity as Indicated by Klein-Gordon, Maxwell, and Dirac Fields in Quasiregular Spacetimes

    NASA Astrophysics Data System (ADS)

    Konkowski, Deborah A.; Arndt, Valerie; Helliwell, Thomas M.

    2002-04-01

    Klein-Gordon, Maxwell and Dirac fields are studied in quasiregular spacetimes, spacetimes with a classical quasiregular singularity, the mildest true classical singularity [G.F.R. Ellis and B.G. Schmidt, Gen. Rel. Grav.8, 915 (1977)]. A class of static quasiregular spacetimes possessing disclinations and dislocations [R.A. Puntigam and H.H. Soleng, Class. Quantum Grav. 14, 1129 (1997)] is shown to have field operators which are not essentially self-adjoint. This class of spacetimes includes an idealized cosmic string, i.e., a four-dimensional spacetime with a conical singularity [L.H. Ford and A. Vilenkin, J. Phys. A: Math. Gen. 14, 2353 (1981)], and a Galtsov/Letelier/Tod spacetime featuring a screw dislocation [K.P. Tod, Class. Quantum Grav. 11, 1331 (1994); D.V. Galtsov and P.S. Letelier, Phys. Rev. D47, 4273 (1993)]. The definition of G. T. Horowitz and D. Marolf [Phys. Rev. D52, 5670 (1995)] for a quantum-mechanically singular spacetime as one in which the spatial-derivative operator in the Klein-Gordon equation for a massive scalar field is not essentially self-adjoint is extended in the case of quasiregular spacetimes to include Maxwell and Dirac fields. Therefore, the class of static quasiregular spacetimes under consideration is quantum-mechanically singular independent of the type of test field.

  17. Nonlinear quantum-mechanical system associated with Sine-Gordon equation in (1 + 2) dimensions

    SciTech Connect

    Zarmi, Yair

    2014-10-15

    Despite the fact that it is not integrable, the (1 + 2)-dimensional Sine-Gordon equation has N-soliton solutions, whose velocities are lower than the speed of light (c = 1), for all N ≥ 1. Based on these solutions, a quantum-mechanical system is constructed over a Fock space of particles. The coordinate of each particle is an angle around the unit circle. U, a nonlinear functional of the particle number-operators, which obeys the Sine-Gordon equation in (1 + 2) dimensions, is constructed. Its eigenvalues on N-particle states in the Fock space are the slower-than-light, N-soliton solutions of the equation. A projection operator (a nonlinear functional of U), which vanishes on the single-particle subspace, is a mass-density generator. Its eigenvalues on multi-particle states play the role of the mass density of structures that emulate free, spatially extended, relativistic particles. The simplicity of the quantum-mechanical system allows for the incorporation of perturbations with particle interactions, which have the capacity to “annihilate” and “create” solitons – an effect that does not have an analog in perturbed classical nonlinear evolution equations.

  18. 2004 Molecular Basis of Microbial One-Carbon Metabolism Gordon Conference - August 1-6, 2004

    SciTech Connect

    Joseph A. Krzycki

    2005-09-15

    The Gordon Research Conference (GRC) on 2004 Molecular Basis of Microbial One-Carbon Metabolism Gordon Conference - August 1-6, 2004 was held at Mount Holyoke College, South Hadley, MA from August 1-6, 2004. The Conference was well-attended with 117 participants (attendees list attached). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. Attached is a copy of the formal schedule and speaker program and the poster program. In addition to these formal interactions, 'free time' was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field.

  19. 1999 Gordon Research Conference on Mammalian DNA Repair. Final Progress Report

    SciTech Connect

    1999-02-12

    This Conference will examine DNA repair as the key component in genomic surveillance that is so crucial to the overall integrity and function of mammalian cells. Recent discoveries have catapulted the field of DNA repair into a pivotal position for fundamental investigations into oncology, aging, environmental health, and developmental biology. We hope to highlight the most promising and exciting avenues of research in robust discussions at this conference. This Mammalian DNA Repair Gordon Conference differs from the past conferences in this series, in which the programs were broader in scope, with respect to topics and biological systems covered. A conference sponsored by the Genetics Society in April 1998 emphasized recombinational mechanisms for double-strand break repair and the role of mismatch repair deficiency in colorectal cancer. These topics will therefore receive somewhat less emphasis in the upcoming Conference. In view of the recent mechanistic advances in mammalian DNA repair, an upcoming comprehensive DNA repair meeting next autumn at Hilton Head; and the limited enrollment for Gordon Conferences we have decided to focus session-by-session on particular areas of controversy and/or new developments specifically in mammalian systems. Thus, the principal presentations will draw upon results from other cellular systems only to the extent that they impact our understanding of mammalian DNA repair.

  20. Efficient and accurate numerical methods for the Klein-Gordon-Schroedinger equations

    SciTech Connect

    Bao, Weizhu . E-mail: bao@math.nus.edu.sg; Yang, Li . E-mail: yangli@nus.edu.sg

    2007-08-10

    In this paper, we present efficient, unconditionally stable and accurate numerical methods for approximations of the Klein-Gordon-Schroedinger (KGS) equations with/without damping terms. The key features of our methods are based on: (i) the application of a time-splitting spectral discretization for a Schroedinger-type equation in KGS (ii) the utilization of Fourier pseudospectral discretization for spatial derivatives in the Klein-Gordon equation in KGS (iii) the adoption of solving the ordinary differential equations (ODEs) in phase space analytically under appropriate chosen transmission conditions between different time intervals or applying Crank-Nicolson/leap-frog for linear/nonlinear terms for time derivatives. The numerical methods are either explicit or implicit but can be solved explicitly, unconditionally stable, and of spectral accuracy in space and second-order accuracy in time. Moreover, they are time reversible and time transverse invariant when there is no damping terms in KGS, conserve (or keep the same decay rate of) the wave energy as that in KGS without (or with a linear) damping term, keep the same dynamics of the mean value of the meson field, and give exact results for the plane-wave solution. Extensive numerical tests are presented to confirm the above properties of our numerical methods for KGS. Finally, the methods are applied to study solitary-wave collisions in one dimension (1D), as well as dynamics of a 2D problem in KGS.

  1. Angiostrongylus cantonensis: role of eosinophils in the neurotoxic syndrome (Gordon-like phenomenon).

    PubMed

    Perez, O; Capron, M; Lastre, M; Venge, P; Khalife, J; Capron, A

    1989-05-01

    The role of eosinophils in the pathophysiology of Angiostrongylus cantonensis infections was investigated in nonpermissive (guinea pig) and permissive (rat) hosts. Neurological symptoms similar to the Gordon phenomenon (ataxia, tremor, paralysis) together with a loss of Purkinje cells in the cerebellum were observed after intracraneal injection of human eosinophil extracts or after infection with A. cantonensis, only in guinea pigs and not in rats. Blood eosinophilia as well as eosinophil numbers present in the cerebellum and in the cerebrospinal fluid were higher in guinea pigs than in rats, at all times after infection with A. cantonensis. Increased levels of cytotoxicity toward L3 larvae in vitro were obtained in the presence of guinea pig eosinophils and IgE antibodies, rather than with the corresponding rat effector system. The detection of one eosinophil granule component, the eosinophil peroxidase, in the cerebrospinal fluid from infected guinea pigs but not from rats suggested that in nonpermissive hosts, neurological disorders, similar to the previously described Gordon phenomenon, might be due to eosinophil neurotoxins released after interaction of eosinophils with the parasites.

  2. Edmund W. Gordon: Producing Knowledge, Pursuing Understanding. Advances in Education in Diverse Communities: Research, Policy, and Praxis, Volume 1.

    ERIC Educational Resources Information Center

    Yeakey, Carol Camp, Ed.

    This volume focuses on the work of Edmund W. Gordon and the influence he has had on contemporary thinking in psychology, education, and social policy, and the implications of his work for the schooling of lower-status youth and children of color in the United States. The chapters are: (1) "The Social Context of Emotions in Black Adolescents:…

  3. Developments in the EPA Computational Toxicology Program to Identify Environmental Endocrine Disruptors ( Environmental Endocrine Disruptors Gordon Conference)

    EPA Science Inventory

    Presentation at the Environmental Endocrine Disruptors Gordon Conference in Newry, ME June 22, 2016 to give an overview of the use of high throughput screening and high throughput toxicokinetics to build models for endocrine disruption by environmental chemicals for estrogen rece...

  4. Spatially Extended Relativistic Particles Out of Traveling Front Solutions of Sine-Gordon Equation in (1+2) Dimensions

    PubMed Central

    Zarmi, Yair

    2016-01-01

    Slower-than-light multi-front solutions of the Sine-Gordon in (1+2) dimensions, constructed through the Hirota algorithm, are mapped onto spatially localized structures, which emulate free, spatially extended, massive relativistic particles. A localized structure is an image of the junctions at which the fronts intersect. It propagates together with the multi-front solution at the velocity of the latter. The profile of the localized structure obeys the linear wave equation in (1+2) dimensions, to which a term that represents interaction with a slower-than-light, Sine-Gordon-multi-front solution has been added. This result can be also formulated in terms of a (1+2)-dimensional Lagrangian system, in which the Sine-Gordon and wave equations are coupled. Expanding the Euler-Lagrange equations in powers of the coupling constant, the zero-order part of the solution reproduces the (1+2)-dimensional Sine-Gordon fronts. The first-order part is the spatially localized structure. PACS: 02.30.Ik, 03.65.Pm, 05.45.Yv, 02.30.Ik. PMID:26930077

  5. How Jeff Gordon and NASCAR Helped to Develop a High School Science Curriculum and Educate Future Teachers

    ERIC Educational Resources Information Center

    Hoodak, Ronald A.

    2004-01-01

    The focus of this article is the development of future science teachers. A research project, involving Cornell University, the Cornell Center for Materials Research, and NASCAR Champion Jeff Gordon is described. All research was conducted in association with faculty and staff at Cornell University and resulted in the development of a science…

  6. Of Madness and Empire: The Rhetor as "Fool" in the Khartoum Siege Journals of Charles Gordon, 1884

    ERIC Educational Resources Information Center

    Bass, Jeff D.

    2007-01-01

    This essay examines the rhetorical persona of the "Fool" as employed by General Charles Gordon in six volumes of journals recorded during the siege of Khartoum by Mahdist forces from September to December, 1884. After identifying the particular rhetorical aspects of the "Fool" as social critic/site of ideological contestation, I argue that Gordon…

  7. 78 FR 27961 - Gordon Foster and Seneca Falls School, Deep Creek Energy LLC; Notice of Transfer of Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Gordon Foster and Seneca Falls School, Deep Creek Energy LLC; Notice of Transfer of Exemption 1. By letter filed March 20, 2013, Mr. Brian Gogarty, Deep Creek Energy LLC...

  8. New exact solutions for fractional Sine-Gordon equation by using the new version of generalized F-expansion method

    NASA Astrophysics Data System (ADS)

    Pandir, Yusuf; Duzgun, Hasan Huseyin

    2016-06-01

    In this study, we investigate some new analytical solutions to the fractional Sine-Gordon equation by using the new version of generalized F-expansion method. The fractional derivatives are defined in the modified Riemann-Liouville context. As a result, new analytical solutions were obtained in terms Jacobi elliptic functions.

  9. Solutions of the Klein-Gordon equation with equal scalar and vector harmonic oscillator plus inverse quadratic potential

    NASA Astrophysics Data System (ADS)

    Ita, B. I.; Obong, H. P.; Ehi-Eromosele, C. O.; Edobor-Osoh, A.; Ikeuba, A. I.

    2014-11-01

    The solutions of the Klein-Gordon equation with equal scalar and vector harmonic oscillator plus inverse quadratic potential for S-waves have been presented using the Nikiforov-Uvarov method. The bound state energy eigenvalues and the corresponding un-normalized eigenfunctions are obtained in terms of the Laguerre polynomials.

  10. Separation of variables and exact solution of the Klein-Gordon and Dirac equations in an open universe

    NASA Astrophysics Data System (ADS)

    Villalba, Víctor M.; Catalá, Esteban Isasi

    2002-10-01

    We solve the Klein-Gordon and Dirac equations in an open cosmological universe with a partially horn topology in the presence of a time dependent magnetic field. Since the exact solution cannot be obtained explicitly for arbitrary time dependence of the field, we discuss the asymptotic behavior of the solutions with the help of the relativistic Hamilton-Jacobi equation.

  11. Children with ANSD fitted with hearing aids applying the AAA Pediatric Amplification Guideline: Current Practice and Outcomes

    PubMed Central

    Walker, Elizabeth A.; McCreery, Ryan W.; Spratford, Meredith; Roush, Patricia A.

    2015-01-01

    Background Up to 15% of children with permanent hearing loss have auditory neuropathy spectrum disorder (ANSD), which involves normal outer hair cell function and disordered afferent neural activity in the auditory nerve or brainstem. Given the varying presentations of ANSD in children, there is a need for more evidence-based research on appropriate clinical interventions for this population. Purpose This study compared the speech production, speech perception, and language outcomes of children with auditory neuropathy spectrum disorder (ANSD) who are hard of hearing and children with similar degrees of mild to moderately-severe sensorineural hearing loss (SNHL), all of whom were fitted with bilateral hearing aids based on the American Academy of Audiology (AAA) pediatric amplification guidelines. Research design Speech perception and communication outcomes data were gathered in a prospective accelerated longitudinal design, with entry into the study between six months and seven years of age. Three sites were involved in participant recruitment: Boys Town National Research Hospital, the University of North Carolina at Chapel Hill, and the University of Iowa. Study sample: The sample consisted of 12 children with ANSD and 22 children with SNHL. The groups were matched based on better-ear pure-tone average, better-ear aided speech intelligibility index, gender, maternal education level, and newborn hearing screening result (i.e., pass or refer). Data collection and analysis Children and their families participated in an initial baseline visit, followed by visits twice a year for children under age 2 years and once a year for children older than 2 years. Paired-sample t-tests were used to compare children with ANSD to children with SNHL. Results Paired t-tests indicated no significant differences between the ANSD and SNHL groups on language and articulation measures. Children with ANSD displayed functional speech perception skills in quiet. Although the number of

  12. Flow-banded Rhyolite of the Northern Oregon Cascades: Graveyard and Gordon Buttes, Tygh Valley, Oregon

    NASA Astrophysics Data System (ADS)

    Westby, E.; Streck, M. J.

    2013-12-01

    One of the most structurally complex areas along the northeastern margin of the Oregon Cascades is in Tygh Valley. Crustal shortening produced folds and extensional tectonics resulted in rifting during the Miocene/Pliocene. Rhyolite, exposed in channel cuts and river canyon, records this transition, summarized in new, more detailed research. Tygh Valley, Oregon, is a synclinal basin bordered by the Tygh Ridge anticline to the north, Mutton Mountains to the south, and the Cascade Range (with Mt. Hood) to the west. The stratigraphy of the basin consists of epi- and volcaniclastic deposits mostly derived from the Cascades Range, in addition to ash flow tuffs and surficial basalt lava flows. Rhyolite lava flows are found at two dome complexes in the Tygh Valley area, Graveyard Butte and Gordon Butte. At Graveyard Butte, the White River has cut a winding canyon 140 meters deep, exposing at its base, a 40-meter thick outcrop of flow-banded rhyolite (73 wt.% SiO2) that laterally extends along the canyon walls for about 1 km. Stratigraphically above the flow-banded rhyolites are locally-erupted Fe-rich andesites (lava flows, agglutinate and other pyroclastic rocks as well as clastic debris), a rhyolitic ash-flow tuff (74 wt.% SiO2) and the 2.7 My basalt lava flows of Juniper Flat. At Gordon Butte, compositionally similar rhyolite lavas are exposed in channel cuts but flows are less constrained on ridge tops due to heavy vegetation. Ongoing age dating experiments will likely reveal a late Miocene/Pliocene age for these rhyolite lava flows. The rhyolite lavas flows at both buttes are chemically nearly indistinguishable but contrast with the stratigraphically younger rhyolitic ash-flow tuff at Graveyard Butte. Rhyolite lavas are richer in Nb and Zr than the younger rhyolitic tuff (Nb 30-40 versus 13 ppm; Zr 490 versus 240 ppm) and share characteristics with much older (~30 Ma) rhyolites of the Western Cascades and John Day Formation of central and eastern Oregon as well as

  13. The Pch2 AAA+ ATPase promotes phosphorylation of the Hop1 meiotic checkpoint adaptor in response to synaptonemal complex defects.

    PubMed

    Herruzo, Esther; Ontoso, David; González-Arranz, Sara; Cavero, Santiago; Lechuga, Ana; San-Segundo, Pedro A

    2016-09-19

    Meiotic cells possess surveillance mechanisms that monitor critical events such as recombination and chromosome synapsis. Meiotic defects resulting from the absence of the synaptonemal complex component Zip1 activate a meiosis-specific checkpoint network resulting in delayed or arrested meiotic progression. Pch2 is an evolutionarily conserved AAA+ ATPase required for the checkpoint-induced meiotic block in the zip1 mutant, where Pch2 is only detectable at the ribosomal DNA array (nucleolus). We describe here that high levels of the Hop1 protein, a checkpoint adaptor that localizes to chromosome axes, suppress the checkpoint defect of a zip1 pch2 mutant restoring Mek1 activity and meiotic cell cycle delay. We demonstrate that the critical role of Pch2 in this synapsis checkpoint is to sustain Mec1-dependent phosphorylation of Hop1 at threonine 318. We also show that the ATPase activity of Pch2 is essential for its checkpoint function and that ATP binding to Pch2 is required for its localization. Previous work has shown that Pch2 negatively regulates Hop1 chromosome abundance during unchallenged meiosis. Based on our results, we propose that, under checkpoint-inducing conditions, Pch2 also possesses a positive action on Hop1 promoting its phosphorylation and its proper distribution on unsynapsed chromosome axes. PMID:27257060

  14. Thyroid Hormone Receptor Interacting Protein 13 (TRIP13) AAA-ATPase Is a Novel Mitotic Checkpoint-silencing Protein*

    PubMed Central

    Wang, Kexi; Sturt-Gillespie, Brianne; Hittle, James C.; Macdonald, Dawn; Chan, Gordon K.; Yen, Tim J.; Liu, Song-Tao

    2014-01-01

    The mitotic checkpoint (or spindle assembly checkpoint) is a fail-safe mechanism to prevent chromosome missegregation by delaying anaphase onset in the presence of defective kinetochore-microtubule attachment. The target of the checkpoint is the E3 ubiquitin ligase anaphase-promoting complex/cyclosome. Once all chromosomes are properly attached and bioriented at the metaphase plate, the checkpoint needs to be silenced. Previously, we and others have reported that TRIP13 AAA-ATPase binds to the mitotic checkpoint-silencing protein p31comet. Here we show that endogenous TRIP13 localizes to kinetochores. TRIP13 knockdown delays metaphase-to-anaphase transition. The delay is caused by prolonged presence of the effector for the checkpoint, the mitotic checkpoint complex, and its association and inhibition of the anaphase-promoting complex/cyclosome. These results suggest that TRIP13 is a novel mitotic checkpoint-silencing protein. The ATPase activity of TRIP13 is essential for its checkpoint function, and interference with TRIP13 abolished p31comet-mediated mitotic checkpoint silencing. TRIP13 overexpression is a hallmark of cancer cells showing chromosomal instability, particularly in certain breast cancers with poor prognosis. We suggest that premature mitotic checkpoint silencing triggered by TRIP13 overexpression may promote cancer development. PMID:25012665

  15. Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31comet

    PubMed Central

    Eytan, Esther; Wang, Kexi; Miniowitz-Shemtov, Shirly; Sitry-Shevah, Danielle; Kaisari, Sharon; Yen, Tim J.; Liu, Song-Tao; Hershko, Avram

    2014-01-01

    The mitotic (or spindle assembly) checkpoint system delays anaphase until all chromosomes are correctly attached to the mitotic spindle. When the checkpoint is active, a Mitotic Checkpoint Complex (MCC) assembles and inhibits the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C). MCC is composed of the checkpoint proteins Mad2, BubR1, and Bub3 associated with the APC/C activator Cdc20. When the checkpoint signal is turned off, MCC is disassembled and the checkpoint is inactivated. The mechanisms of the disassembly of MCC are not sufficiently understood. We have previously observed that ATP hydrolysis is required for the action of the Mad2-binding protein p31comet to disassemble MCC. We now show that HeLa cell extracts contain a factor that promotes ATP- and p31comet-dependent disassembly of a Cdc20–Mad2 subcomplex and identify it as Thyroid Receptor Interacting Protein 13 (TRIP13), an AAA-ATPase known to interact with p31comet. The joint action of TRIP13 and p31comet also promotes the release of Mad2 from MCC, participates in the complete disassembly of MCC and abrogates checkpoint inhibition of APC/C. We propose that TRIP13 plays centrally important roles in the sequence of events leading to MCC disassembly and checkpoint inactivation. PMID:25092294

  16. Multiple sequence signals direct recognition and degradation of protein substrates by the AAA+ protease HslUV.

    PubMed

    Sundar, Shankar; McGinness, Kathleen E; Baker, Tania A; Sauer, Robert T

    2010-10-29

    Proteolysis is important for protein quality control and for the proper regulation of many intracellular processes in prokaryotes and eukaryotes. Discerning substrates from other cellular proteins is a key aspect of proteolytic function. The Escherichia coli HslUV protease is a member of a major family of ATP-dependent AAA+ degradation machines. HslU hexamers recognize and unfold native protein substrates and then translocate the polypeptide into the degradation chamber of the HslV peptidase. Although a wealth of structural information is available for this system, relatively little is known about mechanisms of substrate recognition. Here, we demonstrate that mutations in the unstructured N-terminal and C-terminal sequences of two model substrates alter HslUV recognition and degradation kinetics, including changes in V(max). By introducing N- or C-terminal sequences that serve as recognition sites for specific peptide-binding proteins, we show that blocking either terminus of the substrate interferes with HslUV degradation, with synergistic effects when both termini are obstructed. These results support a model in which one terminus of the substrate is tethered to the protease and the other terminus is engaged by the translocation/unfolding machinery in the HslU pore. Thus, degradation appears to consist of discrete steps, which involve the interaction of different terminal sequence signals in the substrate with different receptor sites in the HslUV protease. PMID:20837023

  17. In-situ monitoring of blood glucose level for dialysis machine by AAA-battery-size ATR Fourier spectroscopy

    NASA Astrophysics Data System (ADS)

    Hosono, Satsuki; Sato, Shun; Ishida, Akane; Suzuki, Yo; Inohara, Daichi; Nogo, Kosuke; Abeygunawardhana, Pradeep K.; Suzuki, Satoru; Nishiyama, Akira; Wada, Kenji; Ishimaru, Ichiro

    2015-07-01

    For blood glucose level measurement of dialysis machines, we proposed AAA-battery-size ATR (Attenuated total reflection) Fourier spectroscopy in middle infrared light region. The proposed one-shot Fourier spectroscopic imaging is a near-common path and spatial phase-shift interferometer with high time resolution. Because numerous number of spectral data that is 60 (= camera frame rare e.g. 60[Hz]) multiplied by pixel number could be obtained in 1[sec.], statistical-averaging improvement realize high-accurate spectral measurement. We evaluated the quantitative accuracy of our proposed method for measuring glucose concentration in near-infrared light region with liquid cells. We confirmed that absorbance at 1600[nm] had high correlations with glucose concentrations (correlation coefficient: 0.92). But to measure whole-blood, complex light phenomenon caused from red blood cells, that is scattering and multiple reflection or so, deteriorate spectral data. Thus, we also proposed the ultrasound-assisted spectroscopic imaging that traps particles at standing-wave node. Thus, if ATR prism is oscillated mechanically, anti-node area is generated around evanescent light field on prism surface. By elimination complex light phenomenon of red blood cells, glucose concentration in whole-blood will be quantify with high accuracy. In this report, we successfully trapped red blood cells in normal saline solution with ultrasonic standing wave (frequency: 2[MHz]).

  18. Roles of the N domain of the AAA+ Lon protease in substrate recognition, allosteric regulation and chaperone activity.

    PubMed

    Wohlever, Matthew L; Baker, Tania A; Sauer, Robert T

    2014-01-01

    Degron binding regulates the activities of the AAA+ Lon protease in addition to targeting proteins for degradation. The sul20 degron from the cell-division inhibitor SulA is shown here to bind to the N domain of Escherichia coli Lon, and the recognition site is identified by cross-linking and scanning for mutations that prevent sul20-peptide binding. These N-domain mutations limit the rates of proteolysis of model sul20-tagged substrates and ATP hydrolysis by an allosteric mechanism. Lon inactivation of SulA in vivo requires binding to the N domain and robust ATP hydrolysis but does not require degradation or translocation into the proteolytic chamber. Lon-mediated relief of proteotoxic stress and protein aggregation in vivo can also occur without degradation but is not dependent on robust ATP hydrolysis. In combination, these results demonstrate that Lon can function as a protease or a chaperone and reveal that some of its ATP-dependent biological activities do not require translocation.

  19. The IbpA and IbpB small heat-shock proteins are substrates of the AAA+ Lon protease.

    PubMed

    Bissonnette, Sarah A; Rivera-Rivera, Izarys; Sauer, Robert T; Baker, Tania A

    2010-03-01

    Small heat-shock proteins (sHSPs) are a widely conserved family of molecular chaperones, all containing a conserved alpha-crystallin domain flanked by variable N- and C-terminal tails. We report that IbpA and IbpB, the sHSPs of Escherichia coli, are substrates for the AAA+ Lon protease. This ATP-fueled enzyme degraded purified IbpA substantially more slowly than purified IbpB, and we demonstrate that this disparity is a consequence of differences in maximal Lon degradation rates and not in substrate affinity. Interestingly, however, IbpB stimulated Lon degradation of IbpA both in vitro and in vivo. Furthermore, although the variable N- and C-terminal tails of the Ibps were dispensable for proteolytic recognition, these tails contain critical determinants that control the maximal rate of Lon degradation. Finally, we show that E. coli Lon degrades variants of human alpha-crystallin, indicating that Lon recognizes conserved determinants in the folded alpha-crystallin domain itself. These results suggest a novel mode for Lon substrate recognition and provide a highly suggestive link between the degradation and sHSP branches of the protein quality-control network.

  20. Random amplified polymorphic DNA (RAPD) detection of dwarf off-types in micropropagated Cavendish (Musa spp. AAA) bananas.

    PubMed

    Damasco, O P; Graham, G C; Henry, R J; Adkins, S W; Smiths, M K; Godwin, I D

    1996-11-01

    A RAPD marker specific to the dwarf off-type (hereafter known as dwarf) from micropropagation of Cavendish banana (Musa spp. AAA) cultivars New Guinea Cavendish and Williams was identified following an analysis of 57 normal (true-to-type) and 59 dwarf plants generated from several different micropropagation events. Sixty-six random decamer primers were used in the initial screen, of which 19 (28.8%) revealed polymorphisms between normal and dwarf plants. Primer OPJ-04 (5'-CCGAACACGG-3') was found to amplify an approx. 1.5 kb band which was consistently present in all normal but absent in all dwarf plants of both cultivars. Reliable detection of dwarf plants was achieved using this marker, providing the only available means ofin vitro detection of dwarfs. The use of this marker could facilitate early detection and elimination of dwarfs from batches of micropropagated bananas, and may be a useful tool in determining what factors in the tissue culture process lead to this off type production.Other micropropagation-induced RAPD polymorphisms were observed but were not associated with the dwarf trait. PMID:24178669

  1. The Pch2 AAA+ ATPase promotes phosphorylation of the Hop1 meiotic checkpoint adaptor in response to synaptonemal complex defects

    PubMed Central

    Herruzo, Esther; Ontoso, David; González-Arranz, Sara; Cavero, Santiago; Lechuga, Ana; San-Segundo, Pedro A.

    2016-01-01

    Meiotic cells possess surveillance mechanisms that monitor critical events such as recombination and chromosome synapsis. Meiotic defects resulting from the absence of the synaptonemal complex component Zip1 activate a meiosis-specific checkpoint network resulting in delayed or arrested meiotic progression. Pch2 is an evolutionarily conserved AAA+ ATPase required for the checkpoint-induced meiotic block in the zip1 mutant, where Pch2 is only detectable at the ribosomal DNA array (nucleolus). We describe here that high levels of the Hop1 protein, a checkpoint adaptor that localizes to chromosome axes, suppress the checkpoint defect of a zip1 pch2 mutant restoring Mek1 activity and meiotic cell cycle delay. We demonstrate that the critical role of Pch2 in this synapsis checkpoint is to sustain Mec1-dependent phosphorylation of Hop1 at threonine 318. We also show that the ATPase activity of Pch2 is essential for its checkpoint function and that ATP binding to Pch2 is required for its localization. Previous work has shown that Pch2 negatively regulates Hop1 chromosome abundance during unchallenged meiosis. Based on our results, we propose that, under checkpoint-inducing conditions, Pch2 also possesses a positive action on Hop1 promoting its phosphorylation and its proper distribution on unsynapsed chromosome axes. PMID:27257060

  2. Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein.

    PubMed

    Wang, Kexi; Sturt-Gillespie, Brianne; Hittle, James C; Macdonald, Dawn; Chan, Gordon K; Yen, Tim J; Liu, Song-Tao

    2014-08-22

    The mitotic checkpoint (or spindle assembly checkpoint) is a fail-safe mechanism to prevent chromosome missegregation by delaying anaphase onset in the presence of defective kinetochore-microtubule attachment. The target of the checkpoint is the E3 ubiquitin ligase anaphase-promoting complex/cyclosome. Once all chromosomes are properly attached and bioriented at the metaphase plate, the checkpoint needs to be silenced. Previously, we and others have reported that TRIP13 AAA-ATPase binds to the mitotic checkpoint-silencing protein p31(comet). Here we show that endogenous TRIP13 localizes to kinetochores. TRIP13 knockdown delays metaphase-to-anaphase transition. The delay is caused by prolonged presence of the effector for the checkpoint, the mitotic checkpoint complex, and its association and inhibition of the anaphase-promoting complex/cyclosome. These results suggest that TRIP13 is a novel mitotic checkpoint-silencing protein. The ATPase activity of TRIP13 is essential for its checkpoint function, and interference with TRIP13 abolished p31(comet)-mediated mitotic checkpoint silencing. TRIP13 overexpression is a hallmark of cancer cells showing chromosomal instability, particularly in certain breast cancers with poor prognosis. We suggest that premature mitotic checkpoint silencing triggered by TRIP13 overexpression may promote cancer development.

  3. Loss of the m-AAA protease subunit AFG₃L₂ causes mitochondrial transport defects and tau hyperphosphorylation.

    PubMed

    Kondadi, Arun Kumar; Wang, Shuaiyu; Montagner, Sara; Kladt, Nikolay; Korwitz, Anne; Martinelli, Paola; Herholz, David; Baker, Michael J; Schauss, Astrid C; Langer, Thomas; Rugarli, Elena I

    2014-05-01

    The m-AAA protease subunit AFG₃L₂ is involved in degradation and processing of substrates in the inner mitochondrial membrane. Mutations in AFG₃L₂ are associated with spinocerebellar ataxia SCA28 in humans and impair axonal development and neuronal survival in mice. The loss of AFG₃L₂ causes fragmentation of the mitochondrial network. However, the pathogenic mechanism of neurodegeneration in the absence of AFG₃L₂ is still unclear. Here, we show that depletion of AFG₃L₂ leads to a specific defect of anterograde transport of mitochondria in murine cortical neurons. We observe similar transport deficiencies upon loss of AFG₃L₂ in OMA1-deficient neurons, indicating that they are not caused by OMA1-mediated degradation of the dynamin-like GTPase OPA1 and inhibition of mitochondrial fusion. Treatment of neurons with antioxidants, such as N-acetylcysteine or vitamin E, or decreasing tau levels in axons restored mitochondrial transport in AFG₃L₂-depleted neurons. Consistently, tau hyperphosphorylation and activation of ERK kinases are detected in mouse neurons postnatally deleted for Afg3l2. We propose that reactive oxygen species signaling leads to cytoskeletal modifications that impair mitochondrial transport in neurons lacking AFG₃L₂.

  4. The Pch2 AAA+ ATPase promotes phosphorylation of the Hop1 meiotic checkpoint adaptor in response to synaptonemal complex defects.

    PubMed

    Herruzo, Esther; Ontoso, David; González-Arranz, Sara; Cavero, Santiago; Lechuga, Ana; San-Segundo, Pedro A

    2016-09-19

    Meiotic cells possess surveillance mechanisms that monitor critical events such as recombination and chromosome synapsis. Meiotic defects resulting from the absence of the synaptonemal complex component Zip1 activate a meiosis-specific checkpoint network resulting in delayed or arrested meiotic progression. Pch2 is an evolutionarily conserved AAA+ ATPase required for the checkpoint-induced meiotic block in the zip1 mutant, where Pch2 is only detectable at the ribosomal DNA array (nucleolus). We describe here that high levels of the Hop1 protein, a checkpoint adaptor that localizes to chromosome axes, suppress the checkpoint defect of a zip1 pch2 mutant restoring Mek1 activity and meiotic cell cycle delay. We demonstrate that the critical role of Pch2 in this synapsis checkpoint is to sustain Mec1-dependent phosphorylation of Hop1 at threonine 318. We also show that the ATPase activity of Pch2 is essential for its checkpoint function and that ATP binding to Pch2 is required for its localization. Previous work has shown that Pch2 negatively regulates Hop1 chromosome abundance during unchallenged meiosis. Based on our results, we propose that, under checkpoint-inducing conditions, Pch2 also possesses a positive action on Hop1 promoting its phosphorylation and its proper distribution on unsynapsed chromosome axes.

  5. Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA

    PubMed Central

    Kandiah, Eaazhisai; Carriel, Diego; Perard, Julien; Malet, Hélène; Bacia, Maria; Liu, Kaiyin; Chan, Sze W. S.; Houry, Walid A.; Ollagnier de Choudens, Sandrine; Elsen, Sylvie; Gutsche, Irina

    2016-01-01

    The inducible lysine decarboxylase LdcI is an important enterobacterial acid stress response enzyme whereas LdcC is its close paralogue thought to play mainly a metabolic role. A unique macromolecular cage formed by two decamers of the Escherichia coli LdcI and five hexamers of the AAA+ ATPase RavA was shown to counteract acid stress under starvation. Previously, we proposed a pseudoatomic model of the LdcI-RavA cage based on its cryo-electron microscopy map and crystal structures of an inactive LdcI decamer and a RavA monomer. We now present cryo-electron microscopy 3D reconstructions of the E. coli LdcI and LdcC, and an improved map of the LdcI bound to the LARA domain of RavA, at pH optimal for their enzymatic activity. Comparison with each other and with available structures uncovers differences between LdcI and LdcC explaining why only the acid stress response enzyme is capable of binding RavA. We identify interdomain movements associated with the pH-dependent enzyme activation and with the RavA binding. Multiple sequence alignment coupled to a phylogenetic analysis reveals that certain enterobacteria exert evolutionary pressure on the lysine decarboxylase towards the cage-like assembly with RavA, implying that this complex may have an important function under particular stress conditions. PMID:27080013

  6. High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97.

    PubMed

    Noi, Kentaro; Yamamoto, Daisuke; Nishikori, Shingo; Arita-Morioka, Ken-ichi; Kato, Takayuki; Ando, Toshio; Ogura, Teru

    2013-11-01

    p97 (also called VCP and CDC-48) is an AAA+ chaperone, which consists of a substrate/cofactor-binding N domain and two ATPase domains (D1 and D2), and forms a homo-hexameric ring. p97 plays crucial roles in a variety of cellular processes such as the ubiquitin-proteasome pathway, the endoplasmic reticulum-associated protein degradation, autophagy, and modulation of protein aggregates. Mutations in human p97 homolog VCP are linked to neurodegenerative diseases. The key mechanism of p97 in these various functions has been proposed to be the disassembly of protein complexes. To understand the molecular mechanism of p97, we studied the conformational changes of hexameric CDC-48.1, a Caenorhabditis elegans p97 homolog, using high-speed atomic force microscopy. In the presence of ATP, the N-D1 ring repeatedly rotates ~23 ± 8° clockwise and resets relative to the D2 ring. Mutational analysis reveals that this rotation is induced by ATP binding to the D2 domain. PMID:24055316

  7. Some Remarks on Similarity and Soliton Solutions of Nonlinear Klein-Gordon Equation

    NASA Astrophysics Data System (ADS)

    Tajiri, Masayoshi

    1984-11-01

    The three-dimensional nonlinear Klein-Gordon [, Higgs field and Yang-Milles] (3D-KG [, H and YM]) equation is first reduced to the 2D nonlinear Schrödinger (2D-NLS) and 2D-KG [, H and YM] equations, and secondly to the 1D-NLS and 1D-KG [, H and YM] equations by similarity transformations. It is shown that similar type soliton solutions of the 3D-KG, H and YM equations, which have singularity on a plane in (x, y, z, t) space, are obtained by substituting the soliton solutions of the 1D-NLS or 1D-KG (or H) equation into the similarity transformations. The soliton solutions of the YM equation are also investigated.

  8. Reculturing and particularizing climate discourses: weather, identity, and the work of Gordon Manley.

    PubMed

    Endfield, Georgina

    2011-01-01

    During the last three decades, popular discourses of climate have been replaced by a global and scientific metanarrative focusing on climate change and global warming. Recent climate scholarship has thus highlighted the need for a reexamination of the idea of climate and its culturally and spatially variable dimensions, though anxieties over the reemergence of climatic determinism in a number of high-profile publications have compounded a reluctance to engage in scholarship exploring the influence of climate on society. This article focuses on the work of British meteorologist and geographer Gordon Manley, whose publications, particularly those produced for popular audiences in the second half of the twentieth century, focus on the relationships between climate, place, and identity in postwar Britain. I argue that his approach may have renewed significance given recent efforts to reparticularize and reculture climate change discourses.

  9. 2010 MULTIPHOTON PROCESSES GORDON RESEARCH CONFERENCE, JUNE 6-11, 2010, TILTON, NH

    SciTech Connect

    Mette Gaarde

    2010-06-11

    The Gordon Research Conference on Multiphoton Processes will be held for the 15th time in 2010. The meeting continues to evolve as it embraces both the rapid technological and intellectual growth in the field as well as the multi-disciplinary expertise of the participants. This time the sessions will focus on: (1) Ultrafast coherent control; (2) Free-electron laser experiments and theory; (3) Generation of harmonics and attosecond pulses; (4) Ultrafast imaging; (5) Applications of very high intensity laser fields; (6) Strong-field processes in molecules and solids; (7) Attosecond science; and (8) Controlling light. The scientific program will blur traditional disciplinary boundaries as the presenters and discussion leaders involve chemists, physicists, and optical engineers, representing both experiment and theory. The broad range of expertise and different perspectives of attendees should provide a stimulating and unique environment for solving problems and developing new ideas in this rapidly evolving field.

  10. 2008 Multiphoton Processes Gordon Research Conferences - June 8-13, 2008

    SciTech Connect

    Mette B. Gaarde

    2009-08-28

    In 2008 the Gordon Research Conference on Multiphoton Processes is held for the 14th time. The meeting continues to evolve as it embraces both the rapid technological and intellectual growth in the field as well as the multi-disciplinary expertise of the participants. This time the sessions will focus on: (1) Attosecond Science; (2) Free-electron laser experiments and theory; (3) Ultrafast dynamics of molecules; (4) Laser control of molecules; (5) Ultrafast imaging; (6) Super-high intensity and x-rays; (7) Strong field processes in molecules; and (8) Control atoms with light and vice versa. The scientific program will blur traditional disciplinary boundaries as the presenters and discussion leaders involve chemists, physicists, and optical engineers, representing both experiment and theory. The broad range of expertise and different perspectives of attendees should provide a stimulating and unique environment for solving problems and developing new ideas in this rapidly evolving field.

  11. 2012 BIOINSPIRED MATERIALS GORDON RESEARCH CONFERENCE, JUNE 24-29, 2012

    SciTech Connect

    Chilkoti, Ashutosh

    2013-06-29

    The emerging, interdisciplinary field of Bioinspired Materials focuses on developing a fundamental understanding of the synthesis, directed self-assembly and hierarchical organization of natural occurring materials, and uses this understanding to engineer new bioinspired artificial materials for diverse applications. The inaugural 2012 Gordon Conference on Bioinspired Materials seeks to capture the excitement of this burgeoning field by a cutting-edge scientific program and roster of distinguished invited speakers and discussion leaders who will address the key issues in the field. The Conference will feature a wide range of topics, such as materials and devices from DNA, reprogramming the genetic code for design of new materials, peptide, protein and carbohydrate based materials, biomimetic systems, complexity in self-assembly, and biomedical applications of bioinspired materials.

  12. Structure of the Broken Phase of the Sine-Gordon Model Using Functional Renormalization

    NASA Astrophysics Data System (ADS)

    Pangon, V.

    We study in this paper the sine-Gordon model using functional renormalization group at local potential approximation using different renormalization group (RG) schemes. In d = 2, using Wegner-Houghton RG we demonstrate that the location of the phase boundary is entirely driven by the relative position to the Coleman fixed point even for strongly coupled bare theories. We show the existence of a set of IR fixed points in the broken phase that are reached independently of the bare coupling. The bad convergence of the Fourier series in the broken phase is discussed and we demonstrate that these fixed points can be found only using a global resolution of the effective potential. We then introduce the methodology for the use of average action method where the regulator breaks periodicity and show that it provides the same conclusions for various regulators. The behavior of the model is then discussed in d≠2 and the absence of the previous fixed points is interpreted.

  13. 2001 Gordon Research Conference on Applied and Environmental Microbiology. Final progress report [agenda and attendee list

    SciTech Connect

    Drake, Harold

    2001-07-26

    The Gordon Research Conference on Applied and Environmental Microbiology was held at Connecticut College, New London, Connecticut, July 22-27, 2001. The conference was attended by 121 participants. The attendees represented the spectrum of endeavor in this field, coming from academia, industry, and government laboratories, and included US and foreign scientists, senior researchers, young investigators, and students. Emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate discussion about the key issues in the field today. Session topics included the following: Environmental and applied genomics, Cell-to-cell signaling and multicellular behavior, Emerging technologies and methods, Novel metabolisms and ecosystems, Directed evolution of enzymes and pathways, Symbiotic and trophic relationships, Synthesis and application of novel biopolymers, and Microbes at the oxic-anoxic interface. There was also a special lecture titled ''Under the umbrella of the big tree: microbial biology into the 21st century.''

  14. 2001 Gordon Research Conference on Photoions, Photoionization and Photodetachment. Final progress report [agenda and attendees list

    SciTech Connect

    Johnson, Mark

    2001-07-13

    The Gordon Research Conference on Photoions, Photoionization and Photodetachment was held at Williams College, Williamstown, Massachusetts, July 8-13, 2001. The 72 conference attendees represented the spectrum of endeavor in this field, coming from academia, industry, and government laboratories, and including US and foreign scientists, senior researchers, young investigators, and students. Emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate discussion about the key issues in the field today. Time for formal presentations was limited. Sessions included the following topics: Vibrational structure, Time resolved studies: nuclear wavepackets, Valence photoionization, Clusters and networks, Resonance structures and decay mechanisms, Ultrafast photoionization, Threshold photoionization, Molecule fixed properties, and Collisional phenomena.

  15. 2013 INORGANIC REACTION MECHANISMS GORDON RESEARCH CONFERENCE (MARCH 3-8, 2013 - HOTEL GALVEZ, GALVESTON TX)

    SciTech Connect

    Abu-Omar, Mahdi M.

    2012-12-08

    The 2013 Gordon Conference on Inorganic Reaction Mechanisms will present cutting-edge research on the molecular aspects of inorganic reactions involving elements from throughout the periodic table and state-of-the art techniques that are used in the elucidation of reaction mechanisms. The Conference will feature a wide range of topics, such as homogeneous and heterogeneous catalysis, metallobiochemistry, electron-transfer in energy reactions, polymerization, nitrogen fixation, green chemistry, oxidation, solar conversion, alkane functionalization, organotransition metal chemistry, and computational chemistry. The talks will cover themes of current interest including energy, materials, and bioinorganic chemistry. Sections cover: Electron-Transfer in Energy Reactions; Catalytic Polymerization and Oxidation Chemistry; Kinetics and Spectroscopy of Heterogeneous Catalysts; Metal-Organic Chemistry and its Application in Synthesis; Green Energy Conversion;Organometallic Chemistry and Activation of Small Molecules; Advances in Kinetics Modeling and Green Chemistry; Metals in Biology and Disease; Frontiers in Catalytic Bond Activation and Cleavage.

  16. Quantum quench dynamics of the sine-Gordon model in some solvable limits

    NASA Astrophysics Data System (ADS)

    Iucci, A.; Cazalilla, M. A.

    2010-05-01

    With regard to the thermalization problem in isolated quantum systems, we investigate the dynamics following a quantum quench of the sine-Gordon model (sGM) in the Luther-Emery and the semiclassical limits. We consider the quench from the gapped to the gapless phase, as well as the reverse one. By obtaining analytic expressions for the one- and two-point correlation functions of the order parameter operator at zero-temperature, the manifestations of integrability in the absence of thermalization in the sGM are studied. It is shown that correlations in the long-time regime after the quench are well described by a generalized Gibbs ensemble. We also consider the case where the system is initially in contact with a reservoir at finite temperature. The possible relevance of our results to current and future experiments with ultracold atomic systems is also considered.

  17. Multisymplectic approach to integrable defects in the sine-Gordon model

    NASA Astrophysics Data System (ADS)

    Caudrelier, Vincent

    2015-05-01

    Ideas from the theory of multisymplectic systems, introduced recently in integrable systems by the author and Kundu to discuss Liouville integrability in classical field theories with a defect, are applied to the sine-Gordon model. The key ingredient is the introduction of a second Poisson bracket in the theory that allows for a Hamiltonian description of the model that is completely equivalent to the standard one, in the absence of a defect. In the presence of a defect described by frozen Bäcklund transformations, our approach based on the new bracket unifies the various tools used so far to attack the problem. It also gets rid of the known issues related to the evaluation of the Poisson brackets of the defect matrix which involve fields at coinciding space point (the location of the defect). The original Lagrangian approach also finds a nice reinterpretation in terms of the canonical transformation representing the defect conditions.

  18. 2001 Gordon Research Conference on Archaea: Ecology [sic], Metabolism. Final progress report [agenda and attendee list

    SciTech Connect

    Daniels, Charles

    2001-08-10

    The Gordon Research Conference on Archaea: Ecology, Metabolism [and Molecular Biology] was held at Proctor Academy, Andover, New Hampshire, August 5-10, 2001. The conference was attended by 135 participants. The attendees represented the spectrum of endeavor in this field, coming from academia, industry, and government laboratories, and included US and foreign scientists, senior researchers, young investigators, and students. Emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate discussion about the key issues in the field today. Session topics included the following: Ecology and genetic elements; Genomics and evolution; Ecology, genomes and gene regulation; Replication and recombination; Chromatin and transcription; Gene regulation; Post-transcription processing; Biochemistry and metabolism; Proteomics and protein structure; Metabolism and physiology. The featured speaker addressed the topic: ''Archaeal viruses, witnesses of prebiotic evolution?''

  19. Klein-Gordon equation and reflection of Alfven waves in nonuniform media

    NASA Technical Reports Server (NTRS)

    Musielak, Z. E.; Fontenla, J. M.; Moore, R. L.

    1992-01-01

    A new analytical approach is presented for assessing the reflection of linear Alfven waves in smoothly nonuniform media. The general one-dimensional case in Cartesian coordinates is treated. It is shown that the wave equations, upon transformation into the form of the Klein-Gordon equation, display a local critical frequency for reflection. At any location in the medium, reflection becomes strong as the wave frequency descends past this characteristic frequency set by the local nonuniformity of the medium. This critical frequecy is given by the transformation as an explicit function of the Alfven velocity and its first and second derivatives, and hence as an explicit spatial function. The transformation thus directly yields, without solution of the wave equations, the location in the medium at which an Alfven wave of any given frequency becomes strongly reflected and has its propagation practically cut off.

  20. Quantum quenches in the sine-Gordon model: A semiclassical approach

    NASA Astrophysics Data System (ADS)

    Kormos, M.; Zaránd, G.

    2016-06-01

    We compute the time evolution of correlation functions after quantum quenches in the sine-Gordon model within the semiclassical approximation, which is expected to yield accurate results for small and slow quenches producing slow quasiparticles with low density. We demonstrate this by reproducing results of a recent form-factor calculation of the relaxation of expectation values [B. Bertini, D. Schuricht, and F. H. L. Essler, J. Stat. Mech. (2014) P10035, 10.1088/1742-5468/2014/10/P10035]. Extending these results, we find that—in the universal limit of vanishingly small quasiparticle velocities—the expectation values of most vertex operators do not decay to zero. We give analytic expressions for the relaxation of dynamic correlation functions and show that they have diffusive behavior for large timelike separation.

  1. 2012 PLANT MOLECULAR BIOLOGY GORDON RESEARCH CONFERENCE, JULY 15-20, 2012

    SciTech Connect

    Sussman, Michael

    2013-07-20

    The 2012 Gordon Conference on Plant Molecular Biology will present cutting-edge research on molecular aspects of plant growth and development, with particular emphasis on recent discoveries in molecular mechanisms involved with plant signaling systems. The Conference will feature a wide range of topics in plant molecular biology including hormone receptors and early events in hormone signaling, plant perception of and response to plant pathogen and symbionts, as well as technological and biological aspects of epigenomics particularly as it relates to signaling systems that regulate plant growth and development. Genomic approaches to plant signaling will be emphasized, including genomic profiling technologies for quantifying various biological subsystems, such as the epigenome, transcriptome, phosphorylome, and metabolome. The meeting will include an important session devoted to answering the question, "What are the biological and technological limits of plant breeding/genetics, and how can they be solved"?

  2. Discrete gap breathers in a diatomic Klein-Gordon chain: stability and mobility.

    PubMed

    Gorbach, Andrey V; Johansson, Magnus

    2003-06-01

    A one-dimensional diatomic chain with harmonic intersite potential and nonlinear external potential is considered (the Klein-Gordon model). Localized solutions of the corresponding nonlinear differential equations with frequencies inside the gap of the linear wave spectrum--"gap breathers"--are studied numerically. The linear stability analysis for these solutions is performed while changing the system parameters from the anticontinuous to the continuous limit. Two different types of solutions are considered: symmetric centered at a heavy atom and antisymmetric centered at a light atom, respectively. Different mechanisms of instability, oscillatory as well as nonoscillatory, of the gap breathers are studied, and the influence of the instabilities on the breather solutions is investigated in the dynamics simulations. In particular, the presence of an "inversion of stability" regime, with simultaneous nonoscillatory instabilities of symmetric and antisymmetric solutions with respect to antisymmetric perturbations, is found, yielding practically radiationless mobility.

  3. Spectral and modulational stability of periodic wavetrains for the nonlinear Klein-Gordon equation

    NASA Astrophysics Data System (ADS)

    Jones, Christopher K. R. T.; Marangell, Robert; Miller, Peter D.; Plaza, Ramón G.

    2014-12-01

    This paper is a detailed and self-contained study of the stability properties of periodic traveling wave solutions of the nonlinear Klein-Gordon equation utt-uxx+V‧(u)=0, where u is a scalar-valued function of x and t, and the potential V(u) is of class C2 and periodic. Stability is considered both from the point of view of spectral analysis of the linearized problem (spectral stability analysis) and from the point of view of wave modulation theory (the strongly nonlinear theory due to Whitham as well as the weakly nonlinear theory of wave packets). The aim is to develop and present new spectral stability results for periodic traveling waves, and to make a solid connection between these results and predictions of the (formal) modulation theory, which has been developed by others but which we review for completeness.

  4. Dynamical Hamiltonian-Hopf instabilities of periodic traveling waves in Klein-Gordon equations

    NASA Astrophysics Data System (ADS)

    Marangell, R.; Miller, P. D.

    2015-07-01

    We study the unstable spectrum close to the imaginary axis for the linearization of the nonlinear Klein-Gordon equation about a periodic traveling wave in a co-moving frame. We define dynamical Hamiltonian-Hopf instabilities as points in the stable spectrum that are accumulation points for unstable spectrum, and show how they can be determined from the knowledge of the discriminant of Hill's equation for an associated periodic potential. This result allows us to give simple criteria for the existence of dynamical Hamiltonian-Hopf instabilities in terms of instability indices previously shown to be useful in stability analysis of periodic traveling waves. We also discuss how these methods can be applied to more general nonlinear wave equations.

  5. A new approximate analytical approach for dispersion relation of the nonlinear Klein-Gordon equation.

    PubMed

    Lim, C. W.; Wu, B. S.; He, L. H.

    2001-12-01

    A novel approach is presented for obtaining approximate analytical expressions for the dispersion relation of periodic wavetrains in the nonlinear Klein-Gordon equation with even potential function. By coupling linearization of the governing equation with the method of harmonic balance, we establish two general analytical approximate formulas for the dispersion relation, which depends on the amplitude of the periodic wavetrain. These formulas are valid for small as well as large amplitude of the wavetrain. They are also applicable to the large amplitude regime, which the conventional perturbation method fails to provide any solution, of the nonlinear system under study. Three examples are demonstrated to illustrate the excellent approximate solutions of the proposed formulas with respect to the exact solutions of the dispersion relation. (c) 2001 American Institute of Physics.

  6. Sharp comparison theorems for the Klein-Gordon equation in d dimensions

    NASA Astrophysics Data System (ADS)

    Hall, Richard L.; Zorin, Petr

    2016-06-01

    We establish sharp (or ’refined’) comparison theorems for the Klein-Gordon equation. We show that the condition Va ≤ Vb, which leads to Ea ≤ Eb, can be replaced by the weaker assumption Ua ≤ Ub which still implies the spectral ordering Ea ≤ Eb. In the simplest case, for d = 1, Ui(x) =∫0xV i(t)dt, i = a or b and for d > 1, Ui(r) =∫0rV i(t)td-1dt, i = a or b. We also consider sharp comparison theorems in the presence of a scalar potential S (a ‘variable mass’) in addition to the vector term V (the time component of a four-vector). The theorems are illustrated by a variety of explicit detailed examples.

  7. Acoustical Klein-Gordon equation: a time-independent perturbation analysis.

    PubMed

    Forbes, Barbara J; Pike, E Roy

    2004-07-30

    The perturbation analysis of an ideal acoustical duct was first made by Rayleigh in 1878 and the result has since stood in the literature. However, the analysis is based on the assumption of potential and kinetic energy densities that remain constant as a change in cross section occurs, whereas, in fact, they may fluctuate significantly in comparison to the slowly varying "wave function," Psi(x,t), of the acoustical Klein-Gordon equation. The square of the time-independent eigenfunction, psi(2)(x), is directly proportional to the potential energy per unit length of fluid, and it is shown that it is precisely the perturbation in potential energy that defines correctly the eigenvalue shifts.

  8. Three-dimensional Einstein-Klein-Gordon system in characteristic numerical relativity

    SciTech Connect

    Barreto, W.; Silva, A. da; Lehner, L.; Gomez, R.; Rosales, L.; Winicour, J.

    2005-03-15

    We incorporate a massless scalar field into a three-dimensional code for the characteristic evolution of the gravitational field. The extended three-dimensional code for the Einstein-Klein-Gordon system is calibrated to be second-order convergent. It provides an accurate calculation of the gravitational and scalar radiation at infinity. As an application, we simulate the fully nonlinear evolution of an asymmetric scalar pulse of ingoing radiation propagating toward an interior Schwarzschild black hole and compute the backscattered scalar and gravitational outgoing radiation patterns. The amplitudes of the scalar and gravitational outgoing radiation modes exhibit the predicted power law scaling with respect to the amplitude of the initial data. For the scattering of an axisymmetric scalar field, the final ring down matches the complex frequency calculated perturbatively for the l=2 quasinormal mode.

  9. Didactic derivation of the special theory of relativity from the Klein-Gordon equation

    NASA Astrophysics Data System (ADS)

    Arodź, H.

    2014-09-01

    We present a didactic derivation of the special theory of relativity in which Lorentz transformations are ‘discovered’ as symmetry transformations of the Klein-Gordon equation. The interpretation of Lorentz boosts as transformations to moving inertial reference frames is not assumed at the start, but it naturally appears at a later stage. The relative velocity v of two inertial reference frames is defined in terms of the elements of the pertinent Lorentz matrix, and the bound |{\\bf v}| is presented as a simple theorem that follows from the structure of the Lorentz group. The polar decomposition of Lorentz matrices is used to explain noncommutativity and nonassociativity of the relativistic composition (‘addition’) of velocities.

  10. Lattice twist operators and vertex operators in sine-Gordon theory in one dimension

    NASA Astrophysics Data System (ADS)

    Nakamura, Masaaki; Voit, Johannes

    2002-04-01

    In one dimension, the exponential position operators introduced in a theory of polarization are identified with the twist operators appearing in the Lieb-Schultz-Mattis argument, and their finite-size expectation values z(q)L measure the overlap between the q-fold degenerate ground state and an excited state. Insulators are characterized by z∞≠0, and different states are distinguished by the sign of zL. We identify zL with ground-state expectation values of vertex operators in the sine-Gordon model. This allows an accurate detection of quantum phase transitions in the universality classes of the Gaussian and the SU(2)1 Wess-Zumino-Novikov-Witten models. We apply this theory to the half-filled extended Hubbard model and obtain agreement with the level-crossing method.

  11. Klein-Gordon versus relativistic Schroedinger equations in pion-nucleus scattering

    SciTech Connect

    McLeod, R.J. )

    1994-06-01

    The relativistic Schroedinger equation and the Klein-Gordon equation for an optical potential for pion scattering are investigated in the resonance energy region and at higher energies. Previous calculations showed that the two equations give nearly the same results with the difference decreasing with increasing energy. We find a substantial difference between the two approaches for [pi][sup +] on [sup 40]Ca at 180 MeV. This difference persists even at 500 MeV. The difference is partly due to the different off-shell behaviors and partly due to the different propagators used. At small angles in the resonance region, the difference can be understood as an energy shift at which the two-body [ital t] matrix is evaluated or as a different range of the two-body interaction.

  12. Quantum quenches in the sine-Gordon model: A semiclassical approach.

    PubMed

    Kormos, M; Zaránd, G

    2016-06-01

    We compute the time evolution of correlation functions after quantum quenches in the sine-Gordon model within the semiclassical approximation, which is expected to yield accurate results for small and slow quenches producing slow quasiparticles with low density. We demonstrate this by reproducing results of a recent form-factor calculation of the relaxation of expectation values [B. Bertini, D. Schuricht, and F. H. L. Essler, J. Stat. Mech. (2014) P100351742-546810.1088/1742-5468/2014/10/P10035]. Extending these results, we find that-in the universal limit of vanishingly small quasiparticle velocities-the expectation values of most vertex operators do not decay to zero. We give analytic expressions for the relaxation of dynamic correlation functions and show that they have diffusive behavior for large timelike separation. PMID:27415202

  13. 1997 Gordon Research Conference on Plant Cell Walls. Final progress report

    SciTech Connect

    Staehelin, A.

    1999-08-25

    The Gordon Research Conference (GRC) on Plant Cell Walls was held at Tilton School, Tilton, New Hampshire, July 18-22, 1997. The conference was well attended with 106 participants. The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both US and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. In addition to these formal interactions, free time was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field.

  14. Non-equilibrium steady states in the Klein-Gordon theory

    NASA Astrophysics Data System (ADS)

    Doyon, Benjamin; Lucas, Andrew; Schalm, Koenraad; Bhaseen, M. J.

    2015-03-01

    We construct non-equilibrium steady states in the Klein-Gordon theory in arbitrary space dimension d following a local quench. We consider the approach where two independently thermalized semi-infinite systems, with temperatures {{T}L} and {{T}R}, are connected along a d-1-dimensional hypersurface. A current-carrying steady state, described by thermally distributed modes with temperatures {{T}L} and {{T}R} for left and right-moving modes, respectively, emerges at late times. The non-equilibrium density matrix is the exponential of a non-local conserved charge. We obtain exact results for the average energy current and the complete distribution of energy current fluctuations. The latter shows that the long-time energy transfer can be described by a continuum of independent Poisson processes, for which we provide the exact weights. We further describe the full time evolution of local observables following the quench. Averages of generic local observables, including the stress-energy tensor, approach the steady state with a power-law in time, where the exponent depends on the initial conditions at the connection hypersurface. We describe boundary conditions and special operators for which the steady state is reached instantaneously on the connection hypersurface. A semiclassical analysis of freely propagating modes yields the average energy current at large distances and late times. We conclude by comparing and contrasting our findings with results for interacting theories and provide an estimate for the timescale governing the crossover to hydrodynamics. As a modification of our Klein-Gordon analysis we also include exact results for free Dirac fermions.

  15. 2012 MOLECULAR AND IONIC CLUSTERS GORDON RESEARCH CONFERENCE, JANUARY 29 - FEBRUARY 3, 2012

    SciTech Connect

    Anne McCoy

    2012-02-03

    The Gordon Research Conference on 'Molecular and Ionic Clusters' focuses on clusters, which are the initial molecular species found in gases when condensation begins to occur. Condensation can take place solely from molecules interacting with each other, mostly at low temperatures, or when molecules condense around charged particles (electrons, protons, metal cations, molecular ions), producing ion molecule clusters. These clusters provide models for solvation, allow a pristine look at geometric as well as electronic structures of molecular complexes or matter in general, their interaction with radiation, their reactivity, their thermodynamic properties and, in particular, the related dynamics. This conference focuses on new ways to make clusters composed of different kinds of molecules, new experimental techniques to investigate the properties of the clusters and new theoretical methods with which to calculate the structures, dynamical motions and energetics of the clusters. Some of the main experimental methods employed include molecular beams, mass spectrometry, laser spectroscopy (from infrared to XUV; in the frequency as well as the time domain) and photoelectron spectroscopy. Techniques include laser absorption spectroscopy, laser induced fluorescence, resonance enhanced photoionization, mass-selected photodissociation, photofragment imaging, ZEKE photoelectron spectroscopy, etc. From the theoretical side, this conference highlights work on potential surfaces and measurable properties of the clusters. The close ties between experiment, theory and computation have been a hallmark of the Gordon Research Conference on Molecular and Ionic Clusters. In the 2012 meeting, we plan to have sessions that will focus on topics including: (1) The use of cluster studies to probe fundamental phenomena; (2) Finite size effects on structure and thermodynamics; (3) Intermolecular forces and cooperative effects; (4) Molecular clusters as models for solvation; and (5) Studies of

  16. Resurgence in sine-Gordon quantum mechanics: exact agreement between multi-instantons and uniform WKB

    NASA Astrophysics Data System (ADS)

    Misumi, Tatsuhiro; Nitta, Muneto; Sakai, Norisuke

    2015-09-01

    We compute multi-instanton amplitudes in the sine-Gordon quantum mechanics (periodic cosine potential) by integrating out quasi-moduli parameters corresponding to separations of instantons and anti-instantons. We propose an extension of Bogomolnyi-Zinn-Justin prescription for multi-instanton configurations and an appropriate subtraction scheme. We obtain the multi-instanton contributions to the energy eigenvalue of the lowest band at the zeroth order of the coupling constant. For the configurations with only instantons (anti-instantons), we obtain unambiguous results. For those with both instantons and anti-instantons, we obtain results with imaginary parts, which depend on the path of analytic continuation. We show that the imaginary parts of the multi-instanton amplitudes precisely cancel the imaginary parts of the Borel resummation of the perturbation series, and verify that our results completely agree with those based on the uniform-WKB calculations, thus confirming the resurgence structure: divergent perturbation series combined with the nonperturbative multi-instanton contributions conspire to give unambiguous results. We also study the neutral bion contributions in the {C}{P}^{N-1} model on {{R}}^1× {S}^1 with a small circumference, taking account of the relative phase moduli between the fractional instanton and anti-instanton. We find that the sign of the interaction potential depends on the relative phase moduli, and that both the real and imaginary parts resulting from quasi-moduli integral of the neutral bion get quantitative corrections compared to the sine-Gordon quantum mechanics.

  17. Applying GORE-TEX technology for rapid contaminant assessments at Fort Gordon, Georgia

    USGS Publications Warehouse

    Falls, Fred W.; Harrelson, Larry G.; Ratliff, W. Hagan; Wellborn, John B.; Landmeyer, James E.

    2010-01-01

    The U.S. Geological Survey, in cooperation with the U.S. Department of the Army at Fort Gordon, Georgia, deployed GORE1 adsorbent samplers along creeks and floodplains to rapidly assess potential contamination at abandoned facilities and in adjacent surface water. The samplers provide screening-level data to determine the presence or absence of volatile organic compounds, semi-volatile organic compounds, and polycyclic aromatic hydrocarbons and were deployed in saturated creek and floodplain sediments adjacent to four abandoned waste-disposal/warfare-training sites. Fuelrelated compounds, not solvents, are the most prevalent organic compounds detected along segments of McCoys Creek adjacent to the 19th Street landfill; South Prong Creek adjacent to the South Prong Creek waste-disposal area; an unnamed tributary to Butler Creek adjacent to the old hospital landfill; and the Brier Creek floodplain adjacent to the Patterson anti-tank range. All 37 samplers deployed in these assessments had detections of total petroleum hydrocarbons ranging from just above 3 (laboratory method detection level) to 344 micrograms per liter. Detections of octane that ranged from 1 to 7.6 micrograms per liter were common in all assessments, except for South Prong Creek. Calculated concentrations of benzene are at or just above the National Primary Drinking Water Standard maximum contaminant level for all samplers deployed in the floodplain at the Patterson anti-tank range. The highest calculated concentration of a specific fuel-related compound was for toluene collected at one sampling site on McCoys Creek adjacent to the 19th Street landfill, but the concentration was below the National Primary Drinking Water Standard. These results are being used by Fort Gordon environmental compliance personnel to decide if further assessments are needed at these abandoned waste-disposal/warfare-training sites

  18. 2011 Photosynthesis Gordon Research Conference & Seminar (June 11-17, 2011, Davidson College, Davidson, North Carolina)

    SciTech Connect

    Prof. Krishna Niyogi

    2011-06-17

    Photosynthesis is the biological process that converts solar energy into chemical energy. Elucidation of the mechanisms of photosynthetic energy conversion at a molecular level is fundamentally important for understanding the biology of photosynthetic organisms, for optimizing biological solar fuels production, and for developing biologically inspired approaches to solar energy conversion. The 2011 Gordon Conference on Photosynthesis will present cutting-edge research focusing on the biochemical aspects of photosynthesis, including: (1) structure, assembly, and function of photosynthetic complexes; (2) the mechanism of water splitting by PSII; (3) light harvesting and quenching; (4) alternative electron transport pathways; (5) biosynthesis of pigments and cofactors; and (6) improvement of photosynthesis for bioenergy and food production. Reflecting the interdisciplinary nature of photosynthesis research, a diverse group of invited speakers will represent a variety of scientific approaches to investigate photosynthesis, such as biochemistry, molecular genetics, structural biology, systems biology, and spectroscopy. Highly interactive poster sessions provide opportunities for graduate students and postdocs to present their work and exchange ideas with leaders in the field. One of the highlights of the Conference is a session featuring short talks by junior investigators selected from the poster presentations. The collegial atmosphere of the Photosynthesis GRC, with programmed discussion sessions as well as informal gatherings in the afternoons and evenings, enables participants to brainstorm, exchange ideas, and forge new collaborations. For the second time, this Conference will be immediately preceded by a Gordon Research Seminar on Photosynthesis (June 11-12, 2011, at the same location), with a focus on 'Photosynthesis, Bioenergy, and the Environment.' The GRS provides an additional opportunity for graduate students and postdocs to present their research, and it

  19. 2012 PHOTOSYNTHESIS GORDON RESEARCH CONFERENCE AND SEMINAR, JUL 7-13, 2012

    SciTech Connect

    Debus, Richard

    2012-07-13

    The Gordon Research Conference on PHOTOSYNTHESIS was held at Davidson College, Davidson, North Carolina, July 8 ? 13, 2012. The Conference was well-attended with 150 participants (attendees list attached). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. Of the 150 attendees, 65 voluntarily responded to a general inquiry regarding ethnicity which appears on our registration forms. Of the 65 respondents, 20% were Minorities ? 5% Hispanic, 15% Asian and 0% African American. Approximately 28% of the participants at the 2012 meeting were women. The Gordon Research Seminar on PHOTOSYNTHESIS held at Davidson College, Davidson, North Carolina, July 7-8, 2012.. The Conference was well-attended with 51 participants (attendees list attached). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. Of the 51 attendees, 22 voluntarily responded to a general inquiry regarding ethnicity which appears on our registration forms. Of the 22 respondents, 14% were Minorities ? 0% Hispanic, 14% Asian and 0% African American. Approximately 35% of the participants at the 2012 meeting were women. Focal points for talks and discussions will include:  Artificial photosynthesis and solar energy conversion strategies;  Engineering organisms for biofuels and hydrogen production;  Electron transport, proton transport, and energy coupling;  Photoprotection mechanisms;  Photosynthetic reaction center structure and function, including rewiring reaction centers for artificial photosynthesis;  Energy capture and light harvesting solutions, including quantum coherence;  Structure of the oxygen evolving complex and the mechanism of oxygen production.

  20. Fall of blood ionized calcium on watching a provocative TV program and its prevention by active absorbable algal calcium (AAA Ca).

    PubMed

    Fujita, T; Ohgitani, S; Nomura, M

    1999-01-01

    In December 1997, more than 680 children developed convulsive seizures while watching a notorious audiovisually provocative TV program, "Pocket Monster." Emotional stimulation via hyperventilation may cause respiratory alkalosis, fall of blood ionized calcium (Ca), and sensitization of the nervous system to excessive emotional stress. A study was therefore undertaken to follow the changes of blood ionized Ca in eight healthy volunteers after watching the "Pocket Monster" and also a quiet program, "Classical Music," as a control for 20min from 4 P.M. Although neither marked hyperventilation nor convulsions developed in any of these adult volunteers, blood ionized Ca showed a significantly more pronounced fall during and after watching "Pocket Monster," and their plasma intact parathyroid hormone (iPTH) was significantly higher 120min after the beginning of "Pocket Monster" than the "Classical Music" program. Plasma total Ca, pH, and albumin were free of detectable changes. Ingestion of 600mg Ca as active absorbable algal Ca (AAA Ca) with high bioavailability completely prevented the fall of ionized Ca and suppressed iPTH. Plama osteocalcin was also significantly suppressed after ingestion of AAA Ca. It may be worthwhile to ingest AAA Ca before anticipated emotional stress such as watching a provocative TV program to prevent possible neuromuscular instability. PMID:10340641

  1. Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structure-based mechanistic dissection of a molecular motor

    SciTech Connect

    Zeymer, Cathleen Barends, Thomas R. M.; Werbeck, Nicolas D.; Schlichting, Ilme; Reinstein, Jochen

    2014-02-01

    High-resolution crystal structures together with mutational analysis and transient kinetics experiments were utilized to understand nucleotide sensing and the regulation of the ATPase cycle in an AAA+ molecular motor. ATPases of the AAA+ superfamily are large oligomeric molecular machines that remodel their substrates by converting the energy from ATP hydrolysis into mechanical force. This study focuses on the molecular chaperone ClpB, the bacterial homologue of Hsp104, which reactivates aggregated proteins under cellular stress conditions. Based on high-resolution crystal structures in different nucleotide states, mutational analysis and nucleotide-binding kinetics experiments, the ATPase cycle of the C-terminal nucleotide-binding domain (NBD2), one of the motor subunits of this AAA+ disaggregation machine, is dissected mechanistically. The results provide insights into nucleotide sensing, explaining how the conserved sensor 2 motif contributes to the discrimination between ADP and ATP binding. Furthermore, the role of a conserved active-site arginine (Arg621), which controls binding of the essential Mg{sup 2+} ion, is described. Finally, a hypothesis is presented as to how the ATPase activity is regulated by a conformational switch that involves the essential Walker A lysine. In the proposed model, an unusual side-chain conformation of this highly conserved residue stabilizes a catalytically inactive state, thereby avoiding unnecessary ATP hydrolysis.

  2. Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase

    PubMed Central

    Schmitz, Karl R.; Sauer, Robert T.

    2014-01-01

    Summary Mycobacterial Clp-family proteases function via collaboration of the heteromeric ClpP1P2 peptidase with a AAA+ partner, ClpX or ClpC1. These enzymes are essential for M. tuberculosis viability and are validated antibacterial drug targets, but the requirements for assembly and regulation of functional proteolytic complexes are poorly understood. Here, we report the reconstitution of protein degradation by mycobacterial Clp proteases in vitro and describe novel features of these enzymes that distinguish them from orthologs in other bacteria. Both ClpX and ClpC1 catalyze ATP-dependent unfolding and degradation of native protein substrates in conjunction with ClpP1P2, but neither mediates protein degradation with just ClpP1 or ClpP2. ClpP1P2 alone has negligible peptidase activity, but is strongly stimulated by translocation of protein substrates into ClpP1P2 by either AAA+ partner. Interestingly, our results support a model in which both binding of a AAA+ partner and protein-substrate delivery are required to stabilize active ClpP1P2. Our model has implications for therapeutically targeting ClpP1P2 in dormant M. tuberculosis, and our reconstituted systems should facilitate identification of novel Clp protease inhibitors and activators. PMID:24976069

  3. FY05 LDRD Fianl Report Investigation of AAA+ protein machines that participate in DNA replication, recombination, and in response to DNA damage LDRD Project Tracking Code: 04-LW-049

    SciTech Connect

    Sawicka, D; de Carvalho-Kavanagh, M S; Barsky, D; Venclovas, C

    2006-12-04

    The AAA+ proteins are remarkable macromolecules that are able to self-assemble into nanoscale machines. These protein machines play critical roles in many cellular processes, including the processes that manage a cell's genetic material, but the mechanism at the molecular level has remained elusive. We applied computational molecular modeling, combined with advanced sequence analysis and available biochemical and genetic data, to structurally characterize eukaryotic AAA+ proteins and the protein machines they form. With these models we have examined intermolecular interactions in three-dimensions (3D), including both interactions between the components of the AAA+ complexes and the interactions of these protein machines with their partners. These computational studies have provided new insights into the molecular structure and the mechanism of action for AAA+ protein machines, thereby facilitating a deeper understanding of processes involved in DNA metabolism.

  4. Theodor Billroth's vision and Karl Ziegler's action: commemoration of the 40th day of death and the 50th anniversary of conferment of Nobel Prize for Chemistry of Karl Ziegler.

    PubMed

    Kapischke, Matthias; Pries, Alexandra

    2014-02-01

    Alloplastic materials are broadly used in modern surgery. Until the middle of the 20th century, metal materials and especially silver were used because of their antimicrobial properties. With the development of a new catalytic process for the production of high-density polyethylene and polypropylene materials, a new era of prosthesis was introduced. These polymers are integral part of our everyday operations surgery, especially in hernia repair. The famous surgeon Billroth mentioned to his pupil Czerny in 1878: "If we could artificially produce tissues of the density and toughness of fascia and tendon, the secret of the radical cure of hernia would be discovered". The polypropylene developed by Karl Ziegler gave the surgeon a material for daily practice, which in its properties (nearly) achieved Billroth's initial vision. In 1963 the Nobel Prize for Chemistry was awarded to Karl Ziegler and Giulio Natta in Stockholm. Furthermore, August 11, 2013 will be the 40th anniversary of Karl Ziegler's death. This manuscript honors both days.

  5. Theodor Billroth's vision and Karl Ziegler's action: commemoration of the 40th day of death and the 50th anniversary of conferment of Nobel Prize for Chemistry of Karl Ziegler.

    PubMed

    Kapischke, Matthias; Pries, Alexandra

    2014-02-01

    Alloplastic materials are broadly used in modern surgery. Until the middle of the 20th century, metal materials and especially silver were used because of their antimicrobial properties. With the development of a new catalytic process for the production of high-density polyethylene and polypropylene materials, a new era of prosthesis was introduced. These polymers are integral part of our everyday operations surgery, especially in hernia repair. The famous surgeon Billroth mentioned to his pupil Czerny in 1878: "If we could artificially produce tissues of the density and toughness of fascia and tendon, the secret of the radical cure of hernia would be discovered". The polypropylene developed by Karl Ziegler gave the surgeon a material for daily practice, which in its properties (nearly) achieved Billroth's initial vision. In 1963 the Nobel Prize for Chemistry was awarded to Karl Ziegler and Giulio Natta in Stockholm. Furthermore, August 11, 2013 will be the 40th anniversary of Karl Ziegler's death. This manuscript honors both days. PMID:24387785

  6. Existence of global decaying solutions to the exterior problem for the Klein-Gordon equation with a nonlinear localized dissipation and a derivative nonlinearity

    NASA Astrophysics Data System (ADS)

    Nakao, Mitsuhiro

    We prove the existence of global decaying solutions to the exterior problem for the Klein-Gordon equation with a nonlinear localized dissipation and a derivative nonlinearity. To derive the required estimates of solutions we employ a 'loan' method.

  7. On a relativistic particle and a relativistic position-dependent mass particle subject to the Klein-Gordon oscillator and the Coulomb potential

    NASA Astrophysics Data System (ADS)

    Vitória, R. L. L.; Furtado, C.; Bakke, K.

    2016-07-01

    The relativistic quantum dynamics of an electrically charged particle subject to the Klein-Gordon oscillator and the Coulomb potential is investigated. By searching for relativistic bound states, a particular quantum effect can be observed: a dependence of the angular frequency of the Klein-Gordon oscillator on the quantum numbers of the system. The meaning of this behaviour of the angular frequency is that only some specific values of the angular frequency of the Klein-Gordon oscillator are permitted in order to obtain bound state solutions. As an example, we obtain both the angular frequency and the energy level associated with the ground state of the relativistic system. Further, we analyse the behaviour of a relativistic position-dependent mass particle subject to the Klein-Gordon oscillator and the Coulomb potential.

  8. High-intensity interval exercise training before abdominal aortic aneurysm repair (HIT-AAA): protocol for a randomised controlled feasibility trial

    PubMed Central

    Tew, Garry A; Weston, Matthew; Kothmann, Elke; Batterham, Alan M; Gray, Joanne; Kerr, Karen; Martin, Denis; Nawaz, Shah; Yates, David; Danjoux, Gerard

    2014-01-01

    Introduction In patients with large abdominal aortic aneurysm (AAA), open surgical or endovascular aneurysm repair procedures are often used to minimise the risk of aneurysm-related rupture and death; however, aneurysm repair itself carries a high risk. Low cardiopulmonary fitness is associated with an increased risk of early post-operative complications and death following elective AAA repair. Therefore, fitness should be enhanced before aneurysm repair. High-intensity interval exercise training (HIT) is a potent, time-efficient strategy for enhancing cardiopulmonary fitness. Here, we describe a feasibility study for a definitive trial of a pre-operative HIT intervention to improve post-operative outcomes in patients undergoing elective AAA repair. Methods and analysis A minimum of 50 patients awaiting elective repair of a 5.5–7.0 cm infrarenal AAA will be allocated by minimisation to HIT or usual care control in a 1:1 ratio. The patients allocated to HIT will complete three hospital-based exercise sessions per week, for 4 weeks. Each session will include 2 or 4 min of high-intensity stationary cycling followed by the same duration of easy cycling or passive recovery, repeated until a total of 16 min of high-intensity exercise is accumulated. Outcomes to be assessed before randomisation and 24–48 h before aneurysm repair include cardiopulmonary fitness, maximum AAA diameter and health-related quality of life. In the post-operative period, we will record destination (ward or critical care unit), organ-specific morbidity, mortality and the durations of critical care and hospital stay. Twelve weeks after the discharge, participants will be interviewed to reassess quality of life and determine post-discharge healthcare utilisation. The costs associated with the exercise intervention and healthcare utilisation will be calculated. Ethics and dissemination Ethics approval was secured through Sunderland Research Ethics Committee. The findings of the trial

  9. Experimental verification of the Acuros XB and AAA dose calculation adjacent to heterogeneous media for IMRT and RapidArc of nasopharygeal carcinoma

    SciTech Connect

    Kan, Monica W. K.; Leung, Lucullus H. T.; So, Ronald W. K.; Yu, Peter K. N.

    2013-03-15

    Purpose: To compare the doses calculated by the Acuros XB (AXB) algorithm and analytical anisotropic algorithm (AAA) with experimentally measured data adjacent to and within heterogeneous medium using intensity modulated radiation therapy (IMRT) and RapidArc{sup Registered-Sign} (RA) volumetric arc therapy plans for nasopharygeal carcinoma (NPC). Methods: Two-dimensional dose distribution immediately adjacent to both air and bone inserts of a rectangular tissue equivalent phantom irradiated using IMRT and RA plans for NPC cases were measured with GafChromic{sup Registered-Sign} EBT3 films. Doses near and within the nasopharygeal (NP) region of an anthropomorphic phantom containing heterogeneous medium were also measured with thermoluminescent dosimeters (TLD) and EBT3 films. The measured data were then compared with the data calculated by AAA and AXB. For AXB, dose calculations were performed using both dose-to-medium (AXB{sub Dm}) and dose-to-water (AXB{sub Dw}) options. Furthermore, target dose differences between AAA and AXB were analyzed for the corresponding real patients. The comparison of real patient plans was performed by stratifying the targets into components of different densities, including tissue, bone, and air. Results: For the verification of planar dose distribution adjacent to air and bone using the rectangular phantom, the percentages of pixels that passed the gamma analysis with the {+-} 3%/3mm criteria were 98.7%, 99.5%, and 97.7% on the axial plane for AAA, AXB{sub Dm}, and AXB{sub Dw}, respectively, averaged over all IMRT and RA plans, while they were 97.6%, 98.2%, and 97.7%, respectively, on the coronal plane. For the verification of planar dose distribution within the NP region of the anthropomorphic phantom, the percentages of pixels that passed the gamma analysis with the {+-} 3%/3mm criteria were 95.1%, 91.3%, and 99.0% for AAA, AXB{sub Dm}, and AXB{sub Dw}, respectively, averaged over all IMRT and RA plans. Within the NP region where

  10. The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes

    PubMed Central

    Mérai, Zsuzsanna; Chumak, Nina; García-Aguilar, Marcelina; Hsieh, Tzung-Fu; Nishimura, Toshiro; Schoft, Vera K.; Bindics, János; Ślusarz, Lucyna; Arnoux, Stéphanie; Opravil, Susanne; Mechtler, Karl; Zilberman, Daniel; Fischer, Robert L.; Tamaru, Hisashi

    2014-01-01

    Centromeres mediate chromosome segregation and are defined by the centromere-specific histone H3 variant (CenH3)/centromere protein A (CENP-A). Removal of CenH3 from centromeres is a general property of terminally differentiated cells, and the persistence of CenH3 increases the risk of diseases such as cancer. However, active mechanisms of centromere disassembly are unknown. Nondividing Arabidopsis pollen vegetative cells, which transport engulfed sperm by extended tip growth, undergo loss of CenH3; centromeric heterochromatin decondensation; and bulk activation of silent rRNA genes, accompanied by their translocation into the nucleolus. Here, we show that these processes are blocked by mutations in the evolutionarily conserved AAA-ATPase molecular chaperone, CDC48A, homologous to yeast Cdc48 and human p97 proteins, both of which are implicated in ubiquitin/small ubiquitin-like modifier (SUMO)-targeted protein degradation. We demonstrate that CDC48A physically associates with its heterodimeric cofactor UFD1-NPL4, known to bind ubiquitin and SUMO, as well as with SUMO1-modified CenH3 and mutations in NPL4 phenocopy cdc48a mutations. In WT vegetative cell nuclei, genetically unlinked ribosomal DNA (rDNA) loci are uniquely clustered together within the nucleolus and all major rRNA gene variants, including those rDNA variants silenced in leaves, are transcribed. In cdc48a mutant vegetative cell nuclei, however, these rDNA loci frequently colocalized with condensed centromeric heterochromatin at the external periphery of the nucleolus. Our results indicate that the CDC48ANPL4 complex actively removes sumoylated CenH3 from centromeres and disrupts centromeric heterochromatin to release bulk rRNA genes into the nucleolus for ribosome production, which fuels single nucleus-driven pollen tube growth and is essential for plant reproduction. PMID:25344531

  11. 40th annual Reed rig census

    SciTech Connect

    Fitts, R.L.; Stokes, T.A. )

    1992-10-01

    This paper reports that declines characterize the 1992 rig census-in the number of available drilling rigs, in the number of active rigs, in rig utilization rate, in the number of rig owners and in industry optimism. The number of rotary rigs available for U.S. drilling fell by 255 units (11.3%) during the past 12 months, an attrition rate almost four times greater than in 1991. But despite the high attrition, only 59.7% of remaining rigs were working during the time the census was taken. Results of the 1992 census bring emphasis to an industry trend that became apparent in early 1991. The major oil companies, and many independents, continued their exodus form the U.S., and the remaining independents, which were hurt by low natural gas prices and unfavorable tax treatment of intangible drilling costs, were not able to pick u the drilling slack. Consequently, the past year has been disastrous for many U.S. drilling contractors, and the outlook for this industry segment remains bleak.

  12. PARTICIPANT SUPPORT FOR THE 2010 GORDON RESEARCH CONFERENCE ON PLASMA PROCESSING SCIENCE (JULY 11-16,2010)

    SciTech Connect

    Uwe Kortshagen

    2011-06-14

    The 2010 Gordon Research Conference on Plasma Processing Science will feature a comprehensive program that will highlight the most cutting edge scientific advances in low temperature plasma science and will explore the applications of low temperature plasma technology relative to many grand societal challenges. Fundamental science sessions will focus on plasma kinetics, plasma surface interactions, and recent trends in plasma generation and multi-phase plasmas. Application sessions will explore the impact of plasma technology in renewable energy and the production of fuels from renewable feedstocks, plasma-enabled medicine and sterilization, and environmental remediation and waste treatment. The conference will bring together in an informal atmosphere leaders in the field with junior investigators and graduate students. The special format of the Gordon Conferences, with programmed discussion sessions and ample time for informal gatherings in the afternoons and evenings, will provide for a fertile atmosphere of brainstorming and creative thinking among the attendees.

  13. Exact solutions of the Klein–Gordon equation in the Kerr–Newman background and Hawking radiation

    SciTech Connect

    Vieira, H.S.; Bezerra, V.B.; Muniz, C.R.

    2014-11-15

    This work considers the influence of the gravitational field produced by a charged and rotating black hole (Kerr–Newman spacetime) on a charged massive scalar field. We obtain exact solutions of both angular and radial parts of the Klein–Gordon equation in this spacetime, which are given in terms of the confluent Heun functions. From the radial solution, we obtain the exact wave solutions near the exterior horizon of the black hole, and discuss the Hawking radiation of charged massive scalar particles. - Highlights: • The covariant Klein–Gordon equation for a charged massive scalar field in the Kerr–Newman black hole is solved. • Both angular and radial parts are transformed to a Heun-type equation. • The resulting Hawking radiation spectrum of scalar particles has a thermal character.

  14. Bound and Scattering State of Position Dependent Mass Klein-Gordon Equation with Hulthen Plus Deformed-Type Hyperbolic Potential

    NASA Astrophysics Data System (ADS)

    Ikot, A. N.; Obong, H. P.; Abbey, T. M.; Zare, S.; Ghafourian, M.; Hassanabadi, H.

    2016-05-01

    In this article we use supersymmetry quantum mechanics and factorization methods to study the bound and scattering state of Klein-Gordon equation with deformed Hulthen plus deformed hyperbolical potential for arbitrary state in D-dimensions. The analytic relativistic bound state eigenvalues and the scattering phase factor are found in closed form. We report on the numerical results for the bound state energy in D-dimensions.

  15. Bound and Scattering State of Position Dependent Mass Klein-Gordon Equation with Hulthen Plus Deformed-Type Hyperbolic Potential

    NASA Astrophysics Data System (ADS)

    Ikot, A. N.; Obong, H. P.; Abbey, T. M.; Zare, S.; Ghafourian, M.; Hassanabadi, H.

    2016-09-01

    In this article we use supersymmetry quantum mechanics and factorization methods to study the bound and scattering state of Klein-Gordon equation with deformed Hulthen plus deformed hyperbolical potential for arbitrary state in D-dimensions. The analytic relativistic bound state eigenvalues and the scattering phase factor are found in closed form. We report on the numerical results for the bound state energy in D-dimensions.

  16. Approximate solutions of Klein—Gordon equation with improved Manning—Rosen potential in D-dimensions using SUSYQM

    NASA Astrophysics Data System (ADS)

    N. Ikot, A.; Hassanabadi, H.; P. Obong, H.; E. Chad Umoren, Y.; N. Isonguyo, C.; H. Yazarloo, B.

    2014-12-01

    In this paper, we present solutions of the Klein-Gordon equation for the improved Manning—Rosen potential for arbitrary l state in d-dimensions using the supersymmetric shape invariance method. We obtained the energy levels and the corresponding wave functions expressed in terms of Jacobi polynomial in a closed form for arbitrary l state. We also calculate the oscillator strength for the potential.

  17. RESERVOIR CHARACTERIZATION OF UPPER DEVONIAN GORDON SANDSTONE, JACKSONBURG STRINGTOWN OIL FIELD, NORTHWESTERN WEST VIRGINIA

    SciTech Connect

    S. Ameri; K. Aminian; K.L. Avary; H.I. Bilgesu; M.E. Hohn; R.R. McDowell; D.L. Matchen

    2001-07-01

    The Jacksonburg-Stringtown oil field contained an estimated 88,500,000 barrels of oil in place, of which approximately 20,000,000 barrels were produced during primary recovery operations. A gas injection project, initiated in 1934, and a pilot waterflood, begun in 1981, yielded additional production from limited portions of the field. The pilot was successful enough to warrant development of a full-scale waterflood in 1990, involving approximately 8,900 acres in three units, with a target of 1,500 barrels of oil per acre recovery. Historical patterns of drilling and development within the field suggests that the Gordon reservoir is heterogeneous, and that detailed reservoir characterization is necessary for understanding well performance and addressing problems observed by the operators. The purpose of this work is to establish relationships among permeability, geophysical and other data by integrating geologic, geophysical and engineering data into an interdisciplinary quantification of reservoir heterogeneity as it relates to production. Conventional stratigraphic correlation and core description shows that the Gordon sandstone is composed of three parasequences, formed along the Late Devonian shoreline of the Appalachian Basin. The parasequences comprise five lithofacies, of which one includes reservoir sandstones. Pay sandstones were found to have permeabilities in core ranging from 10 to 200 mD, whereas non-pay sandstones have permeabilities ranging from below the level of instrumental detection to 5 mD; Conglomeratic zones could take on the permeability characteristics of enclosing materials, or could exhibit extremely low values in pay sandstone and high values in non-pay or low permeability pay sandstone. Four electrofacies based on a linear combination of density and scaled gamma ray best matched correlations made independently based on visual comparison of geophysical logs. Electrofacies 4 with relatively high permeability (mean value > 45 mD) was

  18. Reflection factors and a two-parameter family of boundary bound states in the sinh-Gordon model

    NASA Astrophysics Data System (ADS)

    Corrigan, E.; Taormina, A.

    2000-12-01

    The investigation of boundary breather states of the sinh-Gordon model restricted to a half-line is revisited. Properties of the classical boundary breathers for the two-parameter family of integrable boundary conditions are reviewed and extended. The energy spectrum of the quantized boundary states is computed, firstly by using a bootstrap technique and, subsequently using a WKB approximation. Requiring that the two descriptions of the spectrum agree with one another allows a determination of the relationship between the boundary parameters, the bulk coupling constant, and the two parameters appearing in the reflection factor describing the scattering of the sinh-Gordon particle from the boundary. These calculations had been performed previously for the case in which the boundary conditions preserve the bulk Z2 symmetry of the model. The significantly more difficult case of general boundary conditions which violate the bulk symmetry is treated in this paper. The results clarify the weak-strong-coupling duality of the sinh-Gordon model with integrable boundary conditions.

  19. The Inverse Problem of Klein-Gordon Equation Boundary Value Problem and Its Application in Data Assimilation

    NASA Astrophysics Data System (ADS)

    Mu, Xiyu; Cheng, Hao; Liu, Guoqing

    2016-04-01

    It is often difficult to provide the exact boundary condition in the practical use of variational method. The Euler equation derived from variational method cannot be solved without boundary condition. However, in some application problems such as the assimilation of remote sensing data, the values can be easily obtained in the inner region of the domain. Since the solution of elliptic partial differential equations continuously depends on the boundary condition, the boundary condition can be retrieved using part solutions in the inner area. In this paper, the variational problem of remote sensing data assimilation within a circular area is first established. The Klein-Gordon elliptic equation is derived from the Euler method of variational problems with assumed boundary condition. Secondly, a computer-friendly Green function is constructed for the Dirichlet problem of two-dimensional Klein-Gordon equation, with the formal solution according to Green formula. Thirdly, boundary values are retrieved by solving the optimal problem which is constructed according to the smoothness of boundary value function and the best approximation between formal solutions and high-accuracy measurements in the interior of the domain. Finally, the assimilation problem is solved on substituting the retrieved boundary values into the Klein-Gordon equation. It is a type of inverse problem in mathematics. The advantage of our method lies in that it needs no assumptions of the boundary condition. It thus alleviates the error introduced by artificial boundary condition in data fusion using variational method in the past.

  20. Geomorphology and groundwater origin of amphitheater-shaped gullies at Fort Gordon, Georgia, 2010-2012

    USGS Publications Warehouse

    Landmeyer, James E.; Wellborn, John B.

    2013-01-01

    Seven amphitheater-shaped gullies at valley heads in the northern part of Fort Gordon, Georgia, were identified by personnel from Fort Gordon and the U.S. Geological Survey during a field investigation of environmental contamination near the cantonment area between 2008 and 2010. Between 2010 and 2012, the amphitheater-shaped gullies were photographed, topographic features were surveyed using a global positioning system device, and the extent of erosion was estimated using Light Detection and Ranging imagery. The seven gullies are distributed across a broad area (and most likely are not the only examples) and have a similar geomorphology that includes (1) an amphitheater (semicircular) shaped escarpment at the upgradient end on a plateau of Upper Eocene sands of no readily discernible elevated catchment area or natural surface-water drainage; (2) a narrow, trench-shaped, flat-bottomed incisement of low-permeability marl at the downgradient end; and (3) steep-sided valley walls, some formed by landslides. Surface-water runoff is an unlikely cause for the amphitheater-shaped gullies, because each valley has a relatively small drainage area of sandy terrain even at those gullies that have recently received discharge from stormwater drains. Also, presumed high rates of runoff and gully formation associated with historic land uses, such as clearcutting, cotton production, and silviculture, would have occurred no later than when the fort was established in the early 1900s. The lack of an elevated catchment area at the headward scarps, the amphitheater shape, and presence of low permeability marl at the base of each feature provides the most convincing lines of evidence for headward erosion by groundwater sapping. The absence of current (2013) seeps and springs at most of the amphitheater-shaped gullies indicates that the gullies may have been formed previously by groundwater sapping under conditions of higher and (or) sustained precipitation amounts, local water

  1. The Lon AAA+ protease.

    PubMed

    Gur, Eyal

    2013-01-01

    As the first ATP-dependent protease to be identified, Lon holds a special place in the history of cellular biology. In fact, the concept of ATP-dependent protein degradation was established through the findings that led to the discovery of Lon. Therefore, this chapter begins with a historical perspective, describing the milestones that led to the discovery of Lon and ATP-dependent proteolysis, starting from the early findings in the 1960s until the demonstration of Lon's ATP-dependent proteolytic activity in vitro, in 1981. Most of our knowledge on Lon derives from studies of the Escherichia coli Lon ortholog, and, therefore, most of this chapter relates to this particular enzyme. Nonetheless, Lon is not only found in most bacterial species, it is also found in Archaea and in the mitochondrion and chloroplast of eukaryotic cells. Therefore many of the conclusions gained from studies on the E. coli enzyme are relevant to Lon proteases in other organisms. Lon, more than any other bacterial or organellar protease, is associated with the degradation of misfolded proteins and protein quality control. In addition, Lon also degrades many regulatory proteins that are natively folded, thus it also plays a prominent role in regulation of physiological processes. Throughout the years, many Lon substrates have been identified, confirming its role in the regulation of diverse cellular processes, including cell division, DNA replication, differentiation, and adaptation to stress conditions. Some examples of these functions are described and discussed here, as is the role of Lon in the degradation of misfolded proteins and in protein quality control. Finally, this chapter deals with the exquisite sensitivity of protein degradation inside a cell. How can a protease distinguish so many substrates from cellular proteins that should not be degraded? Can the specificity of a protease be regulated according to the physiological needs of a cell? This chapter thus broadly discusses the substrate specificity of Lon and its allosteric regulation.

  2. Determination of the self-association residues within a homomeric and a heteromeric AAA+ enhancer binding protein.

    PubMed

    Lawton, Edward; Jovanovic, Milija; Joly, Nicolas; Waite, Christopher; Zhang, Nan; Wang, Baojun; Burrows, Patricia; Buck, Martin

    2014-04-17

    The σ(54)-dependent transcription in bacteria requires specific activator proteins, bacterial enhancer binding protein (bEBP), members of the AAA+ (ATPases Associated with various cellular Activities) protein family. The bEBPs usually form oligomers in order to hydrolyze ATP and make open promoter complexes. The bEBP formed by HrpR and HrpS activates transcription from the σ(54)-dependent hrpL promoter responsible for triggering the Type Three Secretion System in Pseudomonas syringae pathovars. Unlike other bEBPs that usually act as homohexamers, HrpR and HrpS operate as a highly co-dependent heterohexameric complex. To understand the organization of the HrpRS complex and the HrpR and HrpS strict co-dependence, we have analyzed the interface between subunits using the random and directed mutagenesis and available crystal structures of several closely related bEBPs. We identified key residues required for the self-association of HrpR (D32, E202 and K235) with HrpS (D32, E200 and K233), showed that the HrpR D32 and HrpS K233 residues form interacting pairs directly involved in an HrpR-HrpS association and that the change in side-chain length at position 233 in HrpS affects self-association and interaction with the HrpR and demonstrated that the HrpS D32, E200 and K233 are not involved in negative regulation imposed by HrpV. We established that the equivalent residues K30, E200 and E234 in a homo-oligomeric bEBP, PspF, are required for the subunit communication and formation of an oligomeric lock that cooperates with the ATP γ-phosphate sensing PspF residue R227, providing insights into their roles in the heteromeric HrpRS co-complex. PMID:24434682

  3. Noncanonical Role for the Host Vps4 AAA+ ATPase ESCRT Protein in the Formation of Tomato Bushy Stunt Virus Replicase

    PubMed Central

    Pogany, Judit; Risco, Cristina; Nagy, Peter D.

    2014-01-01

    Assembling of the membrane-bound viral replicase complexes (VRCs) consisting of viral- and host-encoded proteins is a key step during the replication of positive-stranded RNA viruses in the infected cells. Previous genome-wide screens with Tomato bushy stunt tombusvirus (TBSV) in a yeast model host have revealed the involvement of eleven cellular ESCRT (endosomal sorting complexes required for transport) proteins in viral replication. The ESCRT proteins are involved in endosomal sorting of cellular membrane proteins by forming multiprotein complexes, deforming membranes away from the cytosol and, ultimately, pinching off vesicles into the lumen of the endosomes. In this paper, we show an unexpected key role for the conserved Vps4p AAA+ ATPase, whose canonical function is to disassemble the ESCRT complexes and recycle them from the membranes back to the cytosol. We find that the tombusvirus p33 replication protein interacts with Vps4p and three ESCRT-III proteins. Interestingly, Vps4p is recruited to become a permanent component of the VRCs as shown by co-purification assays and immuno-EM. Vps4p is co-localized with the viral dsRNA and contacts the viral (+)RNA in the intracellular membrane. Deletion of Vps4p in yeast leads to the formation of crescent-like membrane structures instead of the characteristic spherule and vesicle-like structures. The in vitro assembled tombusvirus replicase based on cell-free extracts (CFE) from vps4Δ yeast is highly nuclease sensitive, in contrast with the nuclease insensitive replicase in wt CFE. These data suggest that the role of Vps4p and the ESCRT machinery is to aid building the membrane-bound VRCs, which become nuclease-insensitive to avoid the recognition by the host antiviral surveillance system and the destruction of the viral RNA. Other (+)RNA viruses of plants and animals might also subvert Vps4p and the ESCRT machinery for formation of VRCs, which require membrane deformation and spherule formation. PMID:24763736

  4. Severity of the Aggression/Anxiety-Depression/Attention (A-A-A) CBCL Profile Discriminates between Different Levels of Deficits in Emotional Regulation in Youth with ADHD

    PubMed Central

    Biederman, Joseph; Petty, Carter R.; Day, Helen; Goldin, Rachel L.; Spencer, Thomas; Faraone, Stephen V.; Surman, Craig B.H.; Wozniak, Janet

    2012-01-01

    Objective We examined whether severity scores (1SD vs. 2SDs) of a unique profile of the Child Behavior Checklist (CBCL) consisting of the Anxiety/Depression, Aggression, and Attention (A-A-A) scales would help differentiate levels of deficits in children with ADHD. Study Design Subjects were 197 children with and 224 without ADHD. We defined deficient emotional selfregulation (DESR) as an aggregate cut-off score of >180 but <210 (1SD) on the A-A-A scales of the CBCL (CBCL-DESR) and Severe Dysregulation as an aggregate cut-off score of ≥210 on the same scales (CBCL-Severe Dysregulation). All subjects were assessed with structured diagnostic interviews and a range of functional measures. Results 36% of children with ADHD had a positive CBCL-DESR profile vs. 2% of controls (p<0.001) and 19% had a positive CBCL-Severe Dysregulation profile vs. 0% of controls (p<0.001). The subjects positive for the CBCL-Severe Dysregulation profile differed selectively from those with the CBCL-DESR profile in having higher rates of unipolar and bipolar mood disorders, oppositional defiant and conduct disorders, psychiatric hospitalization at both baseline and follow up assessments, and a higher rate of the CBCL-Severe Dysregulation in siblings. In contrast, the CBCL-DESR was associated with higher rates of comorbid disruptive behavior, anxiety disorders, and impaired interpersonal functioning compared to other ADHD children. Conclusion Severity scores of the A-A-A CBCL profiles can help distinguish two groups of emotional regulation problems in children with ADHD. PMID:22278125

  5. A Screen for Dominant Negative Mutants of SEC18 Reveals a Role for the AAA Protein Consensus Sequence in ATP Hydrolysis

    PubMed Central

    Steel, Gregor J.; Harley, Carol; Boyd, Alan; Morgan, Alan

    2000-01-01

    An evolutionarily ancient mechanism is used for intracellular membrane fusion events ranging from endoplasmic reticulum–Golgi traffic in yeast to synaptic vesicle exocytosis in the human brain. At the heart of this mechanism is the core complex of N-ethylmaleimide-sensitive fusion protein (NSF), soluble NSF attachment proteins (SNAPs), and SNAP receptors (SNAREs). Although these proteins are accepted as key players in vesicular traffic, their molecular mechanisms of action remain unclear. To illuminate important structure–function relationships in NSF, a screen for dominant negative mutants of yeast NSF (Sec18p) was undertaken. This involved random mutagenesis of a GAL1-regulated SEC18 yeast expression plasmid. Several dominant negative alleles were identified on the basis of galactose-inducible growth arrest, of which one, sec18-109, was characterized in detail. The sec18-109 phenotype (abnormal membrane trafficking through the biosynthetic pathway, accumulation of a membranous tubular network, growth suppression, increased cell density) is due to a single A-G substitution in SEC18 resulting in a missense mutation in Sec18p (Thr394→Pro). Thr394 is conserved in most AAA proteins and indeed forms part of the minimal AAA consensus sequence that serves as a signature of this large protein family. Analysis of recombinant Sec18-109p indicates that the mutation does not prevent hexamerization or interaction with yeast α-SNAP (Sec17p), but instead results in undetectable ATPase activity that cannot be stimulated by Sec17p. This suggests a role for the AAA protein consensus sequence in regulating ATP hydrolysis. Furthermore, this approach of screening for dominant negative mutants in yeast can be applied to other conserved proteins so as to highlight important functional domains in their mammalian counterparts. PMID:10749934

  6. Ethnology in the metropole: Robert Knox, Robert Gordon Latham and local sites of observational training.

    PubMed

    Sera-Shriar, Efram

    2011-12-01

    Anthropologists have traditionally separated the history of their discipline into two main diverging methodological paradigms: nineteenth-century armchair theorizing, and twentieth-century field-based research. But this tradition obscures both the complexity of the observational practices of early nineteenth-century researchers and the high degree of continuity between these practices and the techniques that came later. While historians have long since abandoned the notion that nineteenth-century ethnologists and anthropologists were merely 'armchair' theorists, this paper shows that there is still much to learn once one asks more insistently what the observational practices of early researchers were actually like. By way of bringing out this complexity and continuity, this essay re-examines the work of two well-known British ethnologists, Robert Knox, and Robert Gordon Latham; looking in particular at their methods of observing, analysing and representing different racial groups. In the work of each figure, early training in natural history, anatomy and physiology can be seen to have influenced their observational practices when it came to identifying and classifying human varieties. Moreover, in both cases, Knox and Latham developed locally-based observational training sites.

  7. 2009 Plant Lipids: Structure, Metabolism & Function Gordon Research Conference - February 1- 6 ,2009

    SciTech Connect

    Kent D. Chapman

    2009-02-06

    The Gordon Research Conference on 'Plant Lipids: Structure, Metabolism and Function' has been instituted to accelerate research productivity in the field of plant lipids. This conference will facilitate wide dissemination of research breakthroughs, support recruitment of young scientists to the field of plant lipid metabolism and encourage broad participation of the plant lipid community in guiding future directions for research in plant lipids. This conference will build upon the strengths of the successful, previous biannual meetings of the National Plant Lipid Cooperative (www.plantlipids.org) that began in 1993, but will reflect a broader scope of topics to include the biochemistry, cell biology, metabolic regulation, and signaling functions of plant acyl lipids. Most importantly, this conference also will serve as a physical focal point for the interaction of the plant lipid research community. Applications to attend this conference will be open to all researchers interested in plant lipids and will provide a venue for the presentation of the latest research results, networking opportunities for young scientists, and a forum for the development and exchange of useful lipid resources and new ideas. By bringing together senior- and junior-level scientists involved in plant lipid metabolism, a broad range of insights will be shared and the community of plant lipid researchers will function more as a network of vested partners. This is important for the vitality of the research community and for the perceived value that will encourage conference attendance into the future.

  8. Gordon Research Conference on Radiation & Climate in 2009, July 5 -10

    SciTech Connect

    Quiang Fu

    2009-07-10

    The 2009 Gordon Research Conference on Radiation and Climate will present cutting-edge research on the outstanding issues in global climate change with focus on the radiative forcing and sensitivity of the climate system and associated physical processes. The Conference will feature a wide range of topics, including grand challenges in radiation and climate, radiative forcing, climate feedbacks, cloud processes in climate system, hydrological cycle in changing climate, absorbing aerosols and Asian monsoon, recent climate changes, and geo-engineering. The invited speakers will present the recent most important advances and future challenges in these areas. The Conference will bring together a collection of leading investigators who are at the forefront of their field, and will provide opportunities for scientists especially junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.

  9. Harvey Cushing, Gordon Holmes, and the neurological lessons of World War I.

    PubMed

    Lepore, F E

    1994-07-01

    As the gunshots that fatally wounded Archduke Franz Ferdinand and Countess Sophie of Austria resounded from Sarajevo across Europe to become the deafening roar of artillery on the Western Front in August 1914, Harvey Williams Cushing was the world's preeminent neurosurgeon and Gordon Morgan Holmes was arguably the foremost neurologist in the world. The 45-year-old Cushing, and Holmes just 38 years old, would strive to respond to the neurological challenges of World War I. They distinguished themselves amidst the redoubtable efforts of workers such as Walter Cannon, George Riddoch, Charles Sherrington, Henry Head, Victor Horsley, Walther Poppelreuter, and Robert Barany. Even the intense martial spirit of the time would be held in abeyance by the contributions of such men of science, as when the intercession of Prince Carl of Sweden secured the release of Barany from a Russian prisoner-of-war camp and allowed him to accept the 1916 Nobel Prize for his exposition of vestibular physiology. Such respite from the brutality of war was all too brief, and if we are to grasp the significance of the different approaches of Holmes and Cushing to the terrible problems of World War I, we must examine some of the harsh medical realities that they confronted in the "war to end all wars."

  10. Infinite-dimensional Estabrook-Wahlquist prolongations for the sine-Gordon equation

    NASA Astrophysics Data System (ADS)

    Finley, J. D., III; McIver, John K.

    1995-10-01

    We are looking for the universal covering algebra for all symmetries of a given partial differential equation (PDE), using the sine-Gordon equation as a typical example for a nonevolution equation. For nonevolution equations, Estabrook-Wahlquist prolongation structures for nonlocal symmetries depend on the choice of a specific subideal of the contact module to define the PDE. For each inequivalent such choice we determine the most general solution of the prolongation equations, as subalgebras of the (infinite-dimensional) algebra of all vector fields over the space of nonlocal variables associated with the PDE, in the style of Vinogradov covering spaces. We show explicitly how previously known prolongation structures, known to lie within the Kac-Moody algebra, A(1)1, are special cases of these general solutions, although we are unable to identify the most general solutions with previously studied algebras. We show the existence of gauge transformations between prolongation structures, viewed as determining connections over the solution space, and use these to relate (otherwise) distinct algebras. Faithful realizations of the universal algebra allow integral representations of the prolongation structure, opening up interesting connections with algebras of Toeplitz operators over Banach spaces, an area that has only begun to be explored.

  11. 2011 Raditation & Climate Gordon Research Conference (July 10-15 2011- Colby College, Waterville, Maine)

    SciTech Connect

    Prof. Max Hoggblom

    2012-02-09

    The 2011 Gordon Research Conference on Radiation and Climate will present cutting-edge research on outstanding issues in climate change, particularly those in which the interactions between clouds, aerosols, and precipitation play a major role. The Conference will feature a broad range of topics, including grand challenges in atmospheric radiation and climate, cloud and water vapor feedbacks, aerosol-cloud-precipitation-climate interactions across scales, new approaches for remote sensing and in-situ observations of clouds, aerosols and precipitation, and multi-scale modeling challenges. The invited speakers will present the most important recent advances and future challenges in these areas. The Conference will bring together a collection of leading investigators who are at the forefront of their field, and will provide opportunities for scientists, especially junior scientists and graduate students, to present their work in poster format and exchange ideas with leaders in the field. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.

  12. Sine-Gordon modulation solutions: Application to macroscopic non-lubricant friction

    NASA Astrophysics Data System (ADS)

    Gershenzon, Naum I.; Bambakidis, Gust; Skinner, Thomas E.

    2016-10-01

    The Frenkel-Kontorova (FK) model and its continuum approximation, the sine-Gordon (SG) equation, are widely used to model a variety of important nonlinear physical systems. Many practical applications require the wave-train solution, which includes many solitons. In such cases, an important and relevant extension of these models applies Whitham's averaging procedure to the SG equation. The resulting SG modulation equations describe the behavior of important measurable system parameters that are the average of the small-scale solutions given by the SG equation. A fundamental problem of modern physics that is the topic of this paper is the description of the transitional process from a static to a dynamic frictional regime. We have shown that the SG modulation equations are a suitable apparatus for describing this transition. The model provides relations between kinematic (rupture and slip velocities) and dynamic (shear and normal stresses) parameters of the transition process. A particular advantage of the model is its ability to describe frictional processes over a wide range of rupture and slip velocities covering seismic events ranging from regular earthquakes, with rupture velocities on the order of a few km/s, to slow slip events, with rupture velocities on the order of a few km/day.

  13. Sine-Gordon model and the small k+ region of light-cone perturbation theory

    NASA Astrophysics Data System (ADS)

    Griffin, Paul A.

    1992-10-01

    The nonperturbative ultraviolet divergence of the sine-Gordon model is used to study the k+=0 region of light-cone perturbation theory. The light-cone vacuum is shown to be unstable at the nonperturbative β2=8π critical point by a light-cone version of Coleman's variational method. Vacuum bubbles, which are k+=0 diagrams in light-cone field theory and are individually finite and nonvanishing for all β, conspire to generate ultraviolet divergences of the light-cone energy density. The k+=0 region of momentum also contributes to connected Green's functions; the connected two-point function will not diverge, as it should, at the critical point unless diagrams which contribute only at k+=0 are properly included. This analysis shows in a simple way how the k+=0 region cannot be ignored even for connected diagrams. This phenomenon is expected to occur in higher-dimensional gauge theories starting at two-loop order in light-cone perturbation theory.

  14. Supersymmetric quantum mechanics and solitons of the sine-Gordon and nonlinear Schroedinger equations

    SciTech Connect

    Koller, Andrew; Olshanii, Maxim

    2011-12-15

    We present a case demonstrating the connection between supersymmetric quantum mechanics (SUSYQM), reflectionless scattering, and soliton solutions of integrable partial differential equations. We show that the members of a class of reflectionless Hamiltonians, namely, Akulin's Hamiltonians, are connected via supersymmetric chains to a potential-free Hamiltonian, explaining their reflectionless nature. While the reflectionless property in question has been mentioned in the literature for over two decades, the enabling algebraic mechanism was previously unknown. Our results indicate that the multisoliton solutions of the sine-Gordon and nonlinear Schroedinger equations can be systematically generated via the supersymmetric chains connecting Akulin's Hamiltonians. Our findings also explain a well-known but little-understood effect in laser physics: when a two-level atom, initially in the ground state, is subjected to a laser pulse of the form V(t)=(n({h_bar}/2{pi})/{tau})/cosh(t/{tau}), with n being an integer and {tau} being the pulse duration, it remains in the ground state after the pulse has been applied, for any choice of the laser detuning.

  15. 2010 CORRELATED ELECTRON SYSTEMS GORDON RESEARCH CONFERENCE, JUNE 13-18, 2010 For

    SciTech Connect

    Dmitri Basov

    2010-06-18

    The 2010 Gordon Conference on Correlated Electron Systems will present cutting-edge research on emergent properties arising from strong electronic correlations. The Conference will feature a wide range of topics, such as the role of topology in condensed matter systems, quantum Hall interferometry and non-Abelian statistics, quantum criticality, metal-insulator transition, quantum effects in conductivity, Dirac quasiparticles, and superconductivity in cuprates and pnictides. In addition, we are reserving two sessions for new developments in this field that may arise in the coming year. The Conference will bring together a collection of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. We intend to have talks by established leaders in the field and also by young researchers who have made seminal contributions to various aspects of correlated electron physics, The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.

  16. Final state problem for the cubic nonlinear Klein-Gordon equation

    SciTech Connect

    Hayashi, Nakao; Naumkin, Pavel I.

    2009-10-15

    We study the final state problem for the nonlinear Klein-Gordon equation, u{sub tt}+u-u{sub xx}={mu}u{sup 3}, t is an element of R,x is an element of R, where {mu} is an element of R. We prove the existence of solutions in the neighborhood of the approximate solutions 2 Re U(t)w{sub +}(t), where U(t) is the free evolution group defined by U(t)=F{sup -1}e{sup -it<{xi}}{sup >}F, ={radical}(1+x{sup 2}), F and F{sup -1} are the direct and inverse Fourier transformations, respectively, and w{sub +}(t,x)=F{sup -1}(u{sub +}({xi})e{sup (3/2)i{mu}}{sup <{xi}}{sup >{sup 2}}{sup |u{sub +}{sup ({xi})|{sup 2}}{sup log t}), with a given final data u{sub +} is a real-valued function and parallel <{xi}>{sup 3}u{sub +}({xi}) parallel {sub L{sup {infinity}}} is small.

  17. Mutations in PIEZO2 Cause Gordon Syndrome, Marden-Walker Syndrome, and Distal Arthrogryposis Type 5

    PubMed Central

    McMillin, Margaret J.; Beck, Anita E.; Chong, Jessica X.; Shively, Kathryn M.; Buckingham, Kati J.; Gildersleeve, Heidi I.S.; Aracena, Mariana I.; Aylsworth, Arthur S.; Bitoun, Pierre; Carey, John C.; Clericuzio, Carol L.; Crow, Yanick J.; Curry, Cynthia J.; Devriendt, Koenraad; Everman, David B.; Fryer, Alan; Gibson, Kate; Giovannucci Uzielli, Maria Luisa; Graham, John M.; Hall, Judith G.; Hecht, Jacqueline T.; Heidenreich, Randall A.; Hurst, Jane A.; Irani, Sarosh; Krapels, Ingrid P.C.; Leroy, Jules G.; Mowat, David; Plant, Gordon T.; Robertson, Stephen P.; Schorry, Elizabeth K.; Scott, Richard H.; Seaver, Laurie H.; Sherr, Elliott; Splitt, Miranda; Stewart, Helen; Stumpel, Constance; Temel, Sehime G.; Weaver, David D.; Whiteford, Margo; Williams, Marc S.; Tabor, Holly K.; Smith, Joshua D.; Shendure, Jay; Nickerson, Deborah A.; Bamshad, Michael J.

    2014-01-01

    Gordon syndrome (GS), or distal arthrogryposis type 3, is a rare, autosomal-dominant disorder characterized by cleft palate and congenital contractures of the hands and feet. Exome sequencing of five GS-affected families identified mutations in piezo-type mechanosensitive ion channel component 2 (PIEZO2) in each family. Sanger sequencing revealed PIEZO2 mutations in five of seven additional families studied (for a total of 10/12 [83%] individuals), and nine families had an identical c.8057G>A (p.Arg2686His) mutation. The phenotype of GS overlaps with distal arthrogryposis type 5 (DA5) and Marden-Walker syndrome (MWS). Using molecular inversion probes for targeted sequencing to screen PIEZO2, we found mutations in 24/29 (82%) DA5-affected families and one of two MWS-affected families. The presence of cleft palate was significantly associated with c.8057G>A (Fisher’s exact test, adjusted p value < 0.0001). Collectively, although GS, DA5, and MWS have traditionally been considered separate disorders, our findings indicate that they are etiologically related and perhaps represent variable expressivity of the same condition. PMID:24726473

  18. Hydromagnetic waves in a compressed-dipole field via field-aligned Klein-Gordon equations

    NASA Astrophysics Data System (ADS)

    Zheng, Jinlei; Hu, Qiang; Webb, Gary M.; McKenzie, James F.

    2016-05-01

    Hydromagnetic waves, especially those of frequencies in the range of a few millihertz to a few hertz observed in the Earth's magnetosphere, are categorized as ultra low-frequency (ULF) waves or pulsations. They have been extensively studied due to their importance in the interaction with radiation belt particles and in probing the structures of the magnetosphere. We developed an approach to examining the toroidal standing Aflvén waves in a background magnetic field by recasting the wave equation into a Klein-Gordon (KG) form along individual field lines. The eigenvalue solutions to the system are characteristic of a propagation type when the corresponding eigenfrequency is greater than a critical frequency and a decaying type otherwise. We apply the approach to a compressed-dipole magnetic field model of the inner magnetosphere and obtain the spatial profiles of relevant parameters and the spatial wave forms of harmonic oscillations. We further extend the approach to poloidal-mode standing Alfvén waves along field lines. In particular, we present a quantitative comparison with a recent spacecraft observation of a poloidal standing Alfvén wave in the Earth's magnetosphere. Our analysis based on the KG equation yields consistent results which agree with the spacecraft measurements of the wave period and the amplitude ratio between the magnetic field and electric field perturbations.

  19. 2009 MICROBIAL POPULATION BIOLOGY GORDON RESEARCH CONFERENCES JULY 19-24,2009

    SciTech Connect

    ANTHONY DEAN

    2009-07-24

    The 2009 Gordon Conference on Microbial Population Biology will cover a diverse range of cutting edge issues in the microbial sciences and beyond. Firmly founded in evolutionary biology and with a strongly integrative approach, past Conferences have covered a range of topics from the dynamics and genetics of adaptation to the evolution of mutation rate, community ecology, evolutionary genomics, altruism, and epidemiology. The 2009 Conference is no exception, and will include sessions on the evolution of infectious diseases, social evolution, the evolution of symbioses, experimental evolution, adaptive landscapes, community dynamics, and the evolution of protein structure and function. While genomic approaches continue to make inroads, broadening our knowledge and encompassing new questions, the conference will also emphasize the use of experimental approaches to test hypotheses decisively. As in the past, this Conference provides young scientists and graduate students opportunities to present their work in poster format and exchange ideas with leading investigators from a broad spectrum of disciplines. This meeting is never dull: some of the most significant and contentious issues in biology have been thrashed out here. The 2009 meeting will be no exception.

  20. Solitons and chaos of the Klein-Gordon-Zakharov system in a high-frequency plasma

    NASA Astrophysics Data System (ADS)

    Zhen, Hui-Ling; Tian, Bo; Sun, Ya; Chai, Jun; Wen, Xiao-Yong

    2015-10-01

    In this paper, we study the Klein-Gordon-Zakharov (KGZ) system, which describes the interaction between the Langmuir wave and ion sound wave in a high-frequency plasma. By means of the Hirota method and symbolic computation, bright and mixed-type soliton solutions are obtained. For the one soliton, amplitude of E is positively related to β 2 , and that of n is inversely related to β 2 , while they are both positively related to α, where E refers to the high-frequency part of the electrostatic potential of the electric field raised by the electrons, and n represents the deviation of ion density from its equilibrium, β 2 and α are the plasma frequency and ion sound speed, respectively. Head-on interactions between the two bright solitons and two mixed-type ones are respectively displayed. With β 2 increasing, the head-on interaction is transformed into an overtaking one. Bright bound-state solitons are investigated, and the interaction period decreases with α increasing. Furthermore, with the external forces Γ 1 ( t ) and Γ 2 ( t ) introduced, the perturbed KGZ system is studied numerically for its associated chaotic motions. Both the weak and developed chaotic motions can be observed. Γ 1 ( t ) and Γ 2 ( t ) have different effects on the chaotic motions: the chaotic motion can be weakened by decreasing the amplitude of Γ 1 ( t ) or increasing the amplitude and frequency of Γ 2 ( t ) .

  1. A local energy-preserving scheme for Klein-Gordon-Schrödinger equations

    NASA Astrophysics Data System (ADS)

    Cai, Jia-Xiang; Wang, Jia-Lin; Wang, Yu-Shun

    2015-05-01

    A local energy conservation law is proposed for the Klein-Gordon-Schrödinger equations, which is held in any local time-space region. The local property is independent of the boundary condition and more essential than the global energy conservation law. To develop a numerical method preserving the intrinsic properties as much as possible, we propose a local energy-preserving (LEP) scheme for the equations. The merit of the proposed scheme is that the local energy conservation law can hold exactly in any time-space region. With the periodic boundary conditions, the scheme also possesses the discrete change and global energy conservation laws. A nonlinear analysis shows that the LEP scheme converges to the exact solutions with order 𝒪(τ2 + h2). The theoretical properties are verified by numerical experiments. Project supported by the National Natural Science Foundation of China (Grant Nos. 11201169, 11271195, and 41231173) and the Project of Graduate Education Innovation of Jiangsu Province, China (Grant No. CXLX13 366).

  2. Details in Semiconductors Gordon Conference, New London, NH, August 3-8, 2008

    SciTech Connect

    Shengbai Zhang and Nancy Ryan Gray

    2009-09-16

    Continuing its tradition of excellence, this Gordon Conference will focus on research at the forefront of the field of defects in homogeneous and structured semiconductors. The conference will have a strong emphasis on the control of defects during growth and processing, with an increases emphasis on nanostructures as compared to previous conferences. Electronic, magnetic, and optical properties of bulk, thin film, and nanoscale semiconductors will be discussed in detail. In contrast to many conferences, which tend to focus on specific semiconductors, this conference deals with defects in a broad range of bulk and nanoscale electronic materials. This approach has proved to be extremely fruitful for advancing fundamental understanding in emerging materials such as wide-band-gap semiconductors, doped nanoparticles, and organic semiconductors. Presentations of state-of-the-art theoretical methods will contribute to a fundamental understanding of atomic-scale phenomena. The program consists of about twenty invited talks, with plenty of discussion time, and a number of contributed poster sessions. Because of the large amount of discussion time, the conference provides an ideal forum for dealing with topics that are new and/or controversial.

  3. Geology and industrial mineral resources of the Macon-Gordon Kaolin District, Georgia

    USGS Publications Warehouse

    Buie, Bennett Frank; Hetrick, J.H.; Patterson, S.H.; Neeley, C.L.

    1979-01-01

    The Macon-Gordon kaolin district is about 80 miles (130 km) southeast of Atlanta, Georgia. It extends across the boundary between, and includes parts of, the Piedmont and Atlantic Coastal Plain physiographic provinces. The rocks in the Piedmont are mainly intensely folded sericite schist and granite gneiss containing irregular masses of amphibolite and feldspathic biotite gneiss and scattered igneous intrusive rocks. Most of the crystalline rocks are thought to be of Paleozoic age, but some of the intrusive rocks may be younger. The crystalline rocks are cut by a major unconformity and are overlain by sedimentary formations ranging in age from Cretaceous to Miocene. The valuable kaolin deposits occur in the Cretaceous beds, undivided, and in the Huber Formation which is of Paleocene to middle Eocene age. The resources of kaolin in the district are estimated in millions of metric tons as follows: reserves, 100; subeconomic resources, 700 to 900; undiscovered resources, probably 700 to 1,000. In addition to kaolin, the leading mineral commodity mined in the district, crushed stone and sand are now being produced, and fuller's earth and a minor amount of limestone were formerly produced. The crushed stone is quarried from igneous rocks in the Piedmont province. The sand is washed from the Cretaceous beds, undivided. The fuller's earth was mined from the Twiggs Clay Member of the Barnwell Formation, and limestone was dug from the Tivola Limestone.

  4. 2010 MICROBIAL STRESS RESPONSE GORDON RESEARCH CONFERENCE, JULY 18-23, 2010

    SciTech Connect

    Sarah Ades

    2011-07-23

    The 2010 Gordon Research Conference on Microbial Stress Responses provides an open and exciting forum for the exchange of scientific discoveries on the remarkable mechanisms used by microbes to survive in nearly every niche on the planet. Understanding these stress responses is critical for our ability to control microbial survival, whether in the context of biotechnology, ecology, or pathogenesis. From its inception in 1994, this conference has traditionally employed a very broad definition of stress in microbial systems. Sessions will cover the major steps of stress responses from signal sensing to transcriptional regulation to the effectors that mediate responses. A wide range of stresses will be represented. Some examples include (but are not limited to) oxidative stress, protein quality control, antibiotic-induced stress and survival, envelope stress, DNA damage, and nutritional stress. The 2010 meeting will also focus on the role of stress responses in microbial communities, applied and environmental microbiology, and microbial development. This conference brings together researchers from both the biological and physical sciences investigating stress responses in medically- and environmentally relevant microbes, as well as model organisms, using cutting-edge techniques. Computational, systems-level, and biophysical approaches to exploring stress responsive circuits will be integrated throughout the sessions alongside the more traditional molecular, physiological, and genetic approaches. The broad range of excellent speakers and topics, together with the intimate and pleasant setting at Mount Holyoke College, provide a fertile ground for the exchange of new ideas and approaches.

  5. Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5.

    PubMed

    McMillin, Margaret J; Beck, Anita E; Chong, Jessica X; Shively, Kathryn M; Buckingham, Kati J; Gildersleeve, Heidi I S; Aracena, Mariana I; Aylsworth, Arthur S; Bitoun, Pierre; Carey, John C; Clericuzio, Carol L; Crow, Yanick J; Curry, Cynthia J; Devriendt, Koenraad; Everman, David B; Fryer, Alan; Gibson, Kate; Giovannucci Uzielli, Maria Luisa; Graham, John M; Hall, Judith G; Hecht, Jacqueline T; Heidenreich, Randall A; Hurst, Jane A; Irani, Sarosh; Krapels, Ingrid P C; Leroy, Jules G; Mowat, David; Plant, Gordon T; Robertson, Stephen P; Schorry, Elizabeth K; Scott, Richard H; Seaver, Laurie H; Sherr, Elliott; Splitt, Miranda; Stewart, Helen; Stumpel, Constance; Temel, Sehime G; Weaver, David D; Whiteford, Margo; Williams, Marc S; Tabor, Holly K; Smith, Joshua D; Shendure, Jay; Nickerson, Deborah A; Bamshad, Michael J

    2014-05-01

    Gordon syndrome (GS), or distal arthrogryposis type 3, is a rare, autosomal-dominant disorder characterized by cleft palate and congenital contractures of the hands and feet. Exome sequencing of five GS-affected families identified mutations in piezo-type mechanosensitive ion channel component 2 (PIEZO2) in each family. Sanger sequencing revealed PIEZO2 mutations in five of seven additional families studied (for a total of 10/12 [83%] individuals), and nine families had an identical c.8057G>A (p.Arg2686His) mutation. The phenotype of GS overlaps with distal arthrogryposis type 5 (DA5) and Marden-Walker syndrome (MWS). Using molecular inversion probes for targeted sequencing to screen PIEZO2, we found mutations in 24/29 (82%) DA5-affected families and one of two MWS-affected families. The presence of cleft palate was significantly associated with c.8057G>A (Fisher's exact test, adjusted p value < 0.0001). Collectively, although GS, DA5, and MWS have traditionally been considered separate disorders, our findings indicate that they are etiologically related and perhaps represent variable expressivity of the same condition. PMID:24726473

  6. Dosimetric accuracy and clinical quality of Acuros XB and AAA dose calculation algorithm for stereotactic and conventional lung volumetric modulated arc therapy plans

    PubMed Central

    2013-01-01

    Introduction The main aim of the current study was to assess the dosimetric accuracy and clinical quality of volumetric modulated arc therapy (VMAT) plans for stereotactic (stage I) and conventional (stage III) lung cancer treatments planned with Eclipse version 10.0 Anisotropic Analytical Algorithm (AAA) and Acuros XB (AXB) algorithm. Methods The dosimetric impact of using AAA instead of AXB, and grid size 2.5 mm instead of 1.0 mm for VMAT treatment plans was evaluated. The clinical plan quality of AXB VMAT was assessed using 45 stage I and 73 stage III patients, and was compared with published results, planned with VMAT and hybrid-VMAT techniques. Results The dosimetric impact on near-minimum PTV dose (D98%) using AAA instead of AXB was large (underdose up to 12.3%) for stage I and very small (underdose up to 0.8%) for stage III lung treatments. There were no significant differences for dose volume histogram (DVH) values between grid sizes. The calculation time was significantly higher for AXB grid size 1.0 than 2.5 mm (p < 0.01). The clinical quality of the VMAT plans was at least comparable with clinical qualities given in literature of lung treatment plans with VMAT and hybrid-VMAT techniques. The average mean lung dose (MLD), lung V20Gy and V5Gy in this study were respectively 3.6 Gy, 4.1% and 15.7% for 45 stage I patients and 12.4 Gy, 19.3% and 46.6% for 73 stage III lung patients. The average contra-lateral lung dose V5Gy-cont was 35.6% for stage III patients. Conclusions For stereotactic and conventional lung treatments, VMAT calculated with AXB grid size 2.5 mm resulted in accurate dose calculations. No hybrid technique was needed to obtain the dose constraints. AXB is recommended instead of AAA for avoiding serious overestimation of the minimum target doses compared to the actual delivered dose. PMID:23800024

  7. The Multivesicular Bodies (MVBs)-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice.

    PubMed

    Zhu, Xiaobo; Yin, Junjie; Liang, Sihui; Liang, Ruihong; Zhou, Xiaogang; Chen, Zhixiong; Zhao, Wen; Wang, Jing; Li, Weitao; He, Min; Yuan, Can; Miyamoto, Koji; Ma, Bingtian; Wang, Jichun; Qin, Peng; Chen, Weilan; Wang, Yuping; Wang, Wenming; Wu, Xianjun; Yamane, Hisakazu; Zhu, Lihuang; Li, Shigui; Chen, Xuewei

    2016-09-01

    Previous studies have shown that multivesicular bodies (MVBs)/endosomes-mediated vesicular trafficking may play key roles in plant immunity and cell death. However, the molecular regulation is poorly understood in rice. Here we report the identification and characterization of a MVBs-localized AAA ATPase LRD6-6 in rice. Disruption of LRD6-6 leads to enhanced immunity and cell death in rice. The ATPase activity and homo-dimerization of LRD6-6 is essential for its regulation on plant immunity and cell death. An ATPase inactive mutation (LRD6-6E315Q) leads to dominant-negative inhibition in plants. The LRD6-6 protein co-localizes with the MVBs marker protein RabF1/ARA6 and interacts with ESCRT-III components OsSNF7 and OsVPS2. Further analysis reveals that LRD6-6 is required for MVBs-mediated vesicular trafficking and inhibits the biosynthesis of antimicrobial compounds. Collectively, our study shows that the AAA ATPase LRD6-6 inhibits plant immunity and cell death most likely through modulating MVBs-mediated vesicular trafficking in rice. PMID:27618555

  8. The Multivesicular Bodies (MVBs)-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice.

    PubMed

    Zhu, Xiaobo; Yin, Junjie; Liang, Sihui; Liang, Ruihong; Zhou, Xiaogang; Chen, Zhixiong; Zhao, Wen; Wang, Jing; Li, Weitao; He, Min; Yuan, Can; Miyamoto, Koji; Ma, Bingtian; Wang, Jichun; Qin, Peng; Chen, Weilan; Wang, Yuping; Wang, Wenming; Wu, Xianjun; Yamane, Hisakazu; Zhu, Lihuang; Li, Shigui; Chen, Xuewei

    2016-09-01

    Previous studies have shown that multivesicular bodies (MVBs)/endosomes-mediated vesicular trafficking may play key roles in plant immunity and cell death. However, the molecular regulation is poorly understood in rice. Here we report the identification and characterization of a MVBs-localized AAA ATPase LRD6-6 in rice. Disruption of LRD6-6 leads to enhanced immunity and cell death in rice. The ATPase activity and homo-dimerization of LRD6-6 is essential for its regulation on plant immunity and cell death. An ATPase inactive mutation (LRD6-6E315Q) leads to dominant-negative inhibition in plants. The LRD6-6 protein co-localizes with the MVBs marker protein RabF1/ARA6 and interacts with ESCRT-III components OsSNF7 and OsVPS2. Further analysis reveals that LRD6-6 is required for MVBs-mediated vesicular trafficking and inhibits the biosynthesis of antimicrobial compounds. Collectively, our study shows that the AAA ATPase LRD6-6 inhibits plant immunity and cell death most likely through modulating MVBs-mediated vesicular trafficking in rice.

  9. The Multivesicular Bodies (MVBs)-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice

    PubMed Central

    Liang, Sihui; Liang, Ruihong; Zhou, Xiaogang; Chen, Zhixiong; Zhao, Wen; Wang, Jing; Li, Weitao; He, Min; Yuan, Can; Miyamoto, Koji; Ma, Bingtian; Wang, Jichun; Qin, Peng; Chen, Weilan; Wang, Yuping; Wang, Wenming; Wu, Xianjun; Yamane, Hisakazu; Zhu, Lihuang; Li, Shigui; Chen, Xuewei

    2016-01-01

    Previous studies have shown that multivesicular bodies (MVBs)/endosomes-mediated vesicular trafficking may play key roles in plant immunity and cell death. However, the molecular regulation is poorly understood in rice. Here we report the identification and characterization of a MVBs-localized AAA ATPase LRD6-6 in rice. Disruption of LRD6-6 leads to enhanced immunity and cell death in rice. The ATPase activity and homo-dimerization of LRD6-6 is essential for its regulation on plant immunity and cell death. An ATPase inactive mutation (LRD6-6E315Q) leads to dominant-negative inhibition in plants. The LRD6-6 protein co-localizes with the MVBs marker protein RabF1/ARA6 and interacts with ESCRT-III components OsSNF7 and OsVPS2. Further analysis reveals that LRD6-6 is required for MVBs-mediated vesicular trafficking and inhibits the biosynthesis of antimicrobial compounds. Collectively, our study shows that the AAA ATPase LRD6-6 inhibits plant immunity and cell death most likely through modulating MVBs-mediated vesicular trafficking in rice. PMID:27618555

  10. An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2

    PubMed Central

    Heallen, Todd R.; Adams, Henry P.; Furuta, Tokiko; Verbrugghe, Koen J.; Schumacher, Jill M.

    2008-01-01

    SUMMARY The Aurora B kinase is the enzymatic core of the chromosomal passenger complex, which is a critical regulator of mitosis. To identify novel regulators of Aurora B, we performed a genome-wide screen for suppressors of a temperature-sensitive lethal allele of the C. elegans Aurora B kinase AIR-2. This screen uncovered a member of the Afg2/Spaf subfamily of Cdc48-like AAA ATPases as an essential inhibitor of AIR-2 stability and activity. Depletion of CDC-48.3 restores viability to air-2 mutant embryos and leads to abnormally high AIR-2 levels at the late telophase/G1 transition. Furthermore, CDC-48.3 binds directly to AIR-2 and inhibits its kinase activity from metaphase through telophase. While canonical p97/Cdc48 proteins have been assigned contradictory roles in the regulation of Aurora B, our results are the first to identify a member of the Afg2/Spaf AAA ATPases as a critical in vivo inhibitor of this kinase during embryonic development. PMID:18854144

  11. Comparison of build-up region doses in oblique tangential 6 MV photon beams calculated by AAA and CCC algorithms in breast Rando phantom

    NASA Astrophysics Data System (ADS)

    Masunun, P.; Tangboonduangjit, P.; Dumrongkijudom, N.

    2016-03-01

    The purpose of this study is to compare the build-up region doses on breast Rando phantom surface with the bolus covered, the doses in breast Rando phantom and also the doses in a lung that is the heterogeneous region by two algorithms. The AAA in Eclipse TPS and the collapsed cone convolution algorithm in Pinnacle treatment planning system were used to plan in tangential field technique with 6 MV photon beam at 200 cGy total doses in Breast Rando phantom with bolus covered (5 mm and 10 mm). TLDs were calibrated with Cobalt-60 and used to measure the doses in irradiation process. The results in treatment planning show that the doses in build-up region and the doses in breast phantom were closely matched in both algorithms which are less than 2% differences. However, overestimate of doses in a lung (L2) were found in AAA with 13.78% and 6.06% differences at 5 mm and 10 mm bolus thickness, respectively when compared with CCC algorithm. The TLD measurements show the underestimate in buildup region and in breast phantom but the doses in a lung (L2) were overestimated when compared with the doses in the two plannings at both thicknesses of the bolus.

  12. The Torsin-family AAA+ Protein OOC-5 Contains a Critical Disulfide Adjacent to Sensor-II That Couples Redox State to Nucleotide Binding

    PubMed Central

    Zhu, Li; Wrabl, James O.; Hayashi, Adam P.; Rose, Lesilee S.

    2008-01-01

    A subgroup of the AAA+ proteins that reside in the endoplasmic reticulum and the nuclear envelope including human torsinA, a protein mutated in hereditary dystonia, is called the torsin family of AAA+ proteins. A multiple-sequence alignment of this family with Hsp100 proteins of known structure reveals a conserved cysteine in the C-terminus of torsin proteins within the Sensor-II motif. A structural model predicts this cysteine to be a part of an intramolecular disulfide bond, suggesting that it may function as a redox sensor to regulate ATPase activity. In vitro experiments with OOC-5, a torsinA homolog from Caenorhabditis elegans, demonstrate that redox changes that reduce this disulfide bond affect the binding of ATP and ADP and cause an attendant local conformational change detected by limited proteolysis. Transgenic worms expressing an ooc-5 gene with cysteine-to-serine mutations that disrupt the disulfide bond have a very low embryo hatch rate compared with wild-type controls, indicating these two cysteines are essential for OOC-5 function. We propose that the Sensor-II in torsin family proteins is a redox-regulated sensor. This regulatory mechanism may be central to the function of OOC-5 and human torsinA. PMID:18550799

  13. Multicenter Orthopaedic Outcome Network Early Anti-inflammatory Treatment in Patients with Acute ACL Tear” (MOON-AAA) Clinical Trial

    PubMed Central

    Lattermann, Christian; Proffitt, Mary; Huston, Laura J.; Gammon, Lee; Johnson, Darren L.; Kraus, Virginia B.; Spindler, Kurt P.

    2016-01-01

    Objectives: We present the early results from the “Multicenter Orthopaedic Outcome Network Early Anti-inflammatory Treatment in Patients with Acute ACL Tear and Painful Effusions” (MOON-AAA) clinical trial (figure 1). This trial allows for a well controlled prospective cohort of patients with isolated ACL injury at risk for OA. We compared the effect of a single versus a repeated dosage of Kenalog within the first two weeks after ACL injury and its effect on chondral degradation in the first 4 weeks prior to surgical reconstruction of the ACL. Methods: 49 patients with isolated ACL tears were enrolled. Knee joints were aspirated and patients received an injection with 40 mg Kenalog either within 4 days, 10 days, both time points or not at all (saline injection control). Serum, synovial fluid and urine were collected at 3 time points. Permutated block randomization, triple blinding, independent monitoring and standardized x-ray was performed to comply with GCP standards. Patient reported outcomes were collected at 6 time points up to 6 months post-ACL reconstruction(IKDC, KOOS and Marx activity level). A standardized synovial fluid biomarker panel was analyzed according to OARSI guidelines. Statistical analysis were performed using SAS mixed models analysis. Results: Serum analysis shows significant change after injury. Chondrodegradatory markers such as CTX-II, MMP-1 and MMP-3 as well as COMP indicate a progressive destruction of chondral matrix and collagen breakdown . There is a dramatic (250%) increase of CTX-II in the first 4 weeks. Matrix proteins such as MMP-1 and 3 as well as COMP show an initial increase and then a steep decline (see figure 1). Inflammatory markers (IL-1 alpha, IL-1beta, IRAP) show a decline from the time of injury. IL-1 alpha, however shows a dramatic uptake after week 2. This longitudinal data confirms a dramatic onset of early osteoarthritic biomarker profiles immediately after ACL injury as measured in synovial fluid

  14. Research Pilot C. Gordon Fullerton in Cockpit of TU-144LL SST Flying Laboratory

    NASA Technical Reports Server (NTRS)

    1998-01-01

    NASA Research pilot C. Gordon Fullerton sits in cockpit of TU-144LL SST Flying Laboratory. Fullerton was one of two NASA pilots who flew the aircraft as part of a joint high speed research program. NASA teamed with American and Russian aerospace industries for an extended period in a joint international research program featuring the Russian-built Tu-144LL supersonic aircraft. The object of the program was to develop technologies for a proposed future second-generation supersonic airliner to be developed in the 21st Century. The aircraft's initial flight phase began in June 1996 and concluded in February 1998 after 19 research flights. A shorter follow-on program involving seven flights began in September 1998 and concluded in April 1999. All flights were conducted in Russia from Tupolev's facility at the Zhukovsky Air Development Center near Moscow. The centerpiece of the research program was the Tu 144LL, a first-generation Russian supersonic jetliner that was modified by its developer/builder, Tupolev ANTK (aviatsionnyy nauchno-tekhnicheskiy kompleks-roughly, aviation technical complex), into a flying laboratory for supersonic research. Using the Tu-144LL to conduct flight research experiments, researchers compared full-scale supersonic aircraft flight data with results from models in wind tunnels, computer-aided techniques, and other flight tests. The experiments provided unique aerodynamic, structures, acoustics, and operating environment data on supersonic passenger aircraft. Data collected from the research program was being used to develop the technology base for a proposed future American-built supersonic jetliner. Although actual development of such an advanced supersonic transport (SST) is currently on hold, commercial aviation experts estimate that a market for up to 500 such aircraft could develop by the third decade of the 21st Century. The Tu-144LL used in the NASA-sponsored research program was a 'D' model with different engines than were used in

  15. SINGLE MOLECULE APPROACHES TO BIOLOGY, 2010 GORDON RESEARCH CONFERENCE, JUNE 27-JULY 2, 2010, ITALY

    SciTech Connect

    Professor William Moerner

    2010-07-09

    The 2010 Gordon Conference on Single-Molecule Approaches to Biology focuses on cutting-edge research in single-molecule science. Tremendous technical developments have made it possible to detect, identify, track, and manipulate single biomolecules in an ambient environment or even in a live cell. Single-molecule approaches have changed the way many biological problems are addressed, and new knowledge derived from these approaches continues to emerge. The ability of single-molecule approaches to avoid ensemble averaging and to capture transient intermediates and heterogeneous behavior renders them particularly powerful in elucidating mechanisms of biomolecular machines: what they do, how they work individually, how they work together, and finally, how they work inside live cells. The burgeoning use of single-molecule methods to elucidate biological problems is a highly multidisciplinary pursuit, involving both force- and fluorescence-based methods, the most up-to-date advances in microscopy, innovative biological and chemical approaches, and nanotechnology tools. This conference seeks to bring together top experts in molecular and cell biology with innovators in the measurement and manipulation of single molecules, and will provide opportunities for junior scientists and graduate students to present their work in poster format and to exchange ideas with leaders in the field. A number of excellent poster presenters will be selected for short oral talks. Topics as diverse as single-molecule sequencing, DNA/RNA/protein interactions, folding machines, cellular biophysics, synthetic biology and bioengineering, force spectroscopy, new method developments, superresolution imaging in cells, and novel probes for single-molecule imaging will be on the program. Additionally, the collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings in the beauty of the Il Ciocco site in

  16. Cylindric partitions, {{\\boldsymbol{ W }}}_{r} characters and the Andrews-Gordon-Bressoud identities

    NASA Astrophysics Data System (ADS)

    Foda, O.; Welsh, T. A.

    2016-04-01

    We study the Andrews-Gordon-Bressoud (AGB) generalisations of the Rogers-Ramanujan q-series identities in the context of cylindric partitions. We recall the definition of r-cylindric partitions, and provide a simple proof of Borodin’s product expression for their generating functions, that can be regarded as a limiting case of an unpublished proof by Krattenthaler. We also recall the relationships between the r-cylindric partition generating functions, the principal characters of {\\hat{{sl}}}r algebras, the {{\\boldsymbol{ M }}}r r,r+d minimal model characters of {{\\boldsymbol{ W }}}r algebras, and the r-string abaci generating functions, providing simple proofs for each. We then set r = 2, and use two-cylindric partitions to re-derive the AGB identities as follows. Firstly, we use Borodin’s product expression for the generating functions of the two-cylindric partitions with infinitely long parts, to obtain the product sides of the AGB identities, times a factor {(q;q)}∞ -1, which is the generating function of ordinary partitions. Next, we obtain a bijection from the two-cylindric partitions, via two-string abaci, into decorated versions of Bressoud’s restricted lattice paths. Extending Bressoud’s method of transforming between restricted paths that obey different restrictions, we obtain sum expressions with manifestly non-negative coefficients for the generating functions of the two-cylindric partitions which contains a factor {(q;q)}∞ -1. Equating the product and sum expressions of the same two-cylindric partitions, and canceling a factor of {(q;q)}∞ -1 on each side, we obtain the AGB identities.

  17. 2010 Electron Donor-Acceptor Interactions Gordon Research Conference, August 8 - 13, 2010.

    SciTech Connect

    Gerald Meyer

    2010-08-18

    The Gordon Research Conference on Electron Donor Acceptor Interactions (GRC EDAI) presents and advances the current frontiers in experimental and theoretical studies of Electron Transfer Processes and Energy Conversion. The fundamental concepts underpinning the field of electron transfer and charge transport phenomena are understood, but fascinating experimental discoveries and novel applications based on charge transfer processes are expanding the discipline. Simultaneously, global challenges for development of viable and economical alternative energy resources, on which many researchers in the field focus their efforts, are now the subject of daily news headlines. Enduring themes of this conference relate to photosynthesis, both natural and artificial, and solar energy conversion. More recent developments include molecular electronics, optical switches, and nanoscale charge transport structures of both natural (biological) and man-made origin. The GRC EDAI is one of the major international meetings advancing this field, and is one of the few scientific meetings where fundamental research in solar energy conversion has a leading voice. The program includes sessions on coupled electron transfers, molecular solar energy conversion, biological and biomimetic systems, spin effects, ultrafast reactions and technical frontiers as well as electron transport in single molecules and devices. In addition to disseminating the latest advances in the field of electron transfer processes, the conference is an excellent forum for scientists from different disciplines to meet and initiate new directions; for scientists from different countries to make contacts; for young scientists to network and establish personal contacts with other young scientists and with established scientists who, otherwise, might not have the time to meet young people. The EDAI GRC also features an interactive atmosphere with lively poster sessions, a few of which are selected for oral presentations.

  18. 2008 Co2 Assimilation in Plants: Genome to Biome Gordon Research Conference - August 17-22

    SciTech Connect

    James V. Maroney

    2009-08-12

    Formerly entitled 'CO2 Fixation and Metabolism in Green Plants', this long-standing Gordon Research Conference has been held on a triennial basis since 1976. In 1990 the participants decided to alternate between sites in the U.S. and outside the U.S. The 2005 conference was held in Europe at the Centre Paul Langevin in Aussois, France, so the 2008 conference returns to a U.S. site - the University of New England in Biddeford, Maine. The 2008 conference covers basic plant research related to photosynthesis and the subsequent regulation and engineering of carbon assimilation. Approaches that range from post-genomic technologies and systems biology, through to fundamental biochemistry, physiology and molecular biology are integrated within ecological and agronomic contexts. As such, the meeting provides the rare opportunity of a single venue for discussing all aspects of the 'carbon-side' of photosynthesis - from genome to biome. The 2008 conference will include an emphasis on the central role of carbon assimilation by plants for developing new sources of bioenergy and for achieving a carbon-neutral planet. A special characteristic of this conference is its 'intimacy' with approximately 110 conferees, ranging from beginning graduate students and postdoctoral associates to leading senior plant scientists, engaged in open and forward-thinking discussions in an informal, friendly setting. With extended time devoted to discussion, and the encouragement to challenge dogma, it is unlike other meetings in the U.S. or abroad. Another novel feature of the conference is a session devoted to the latest 'hot off the press' findings by both established and early career scientists, picked from the abstracts. Together with an expanded poster discussion in the evening sessions, this session provides an opportunity for early career scientists to present interesting new data and to 'test drive' hypotheses in a collegial atmosphere.

  19. The Global Nonlinear Stability of Minkowski Space for Self-gravitating Massive Fields. The Wave-Klein-Gordon Model

    NASA Astrophysics Data System (ADS)

    LeFloch, Philippe G.; Ma, Yue

    2016-09-01

    The Hyperboloidal Foliation Method (introduced by the authors in 2014) is extended here and applied to the Einstein equations of general relativity. Specifically, we establish the nonlinear stability of Minkowski spacetime for self-gravitating massive scalar fields, while existing methods only apply to massless scalar fields. First of all, by analyzing the structure of the Einstein equations in wave coordinates, we exhibit a nonlinear wave-Klein-Gordon model defined on a curved background, which is the focus of the present paper. For this model, we prove here the existence of global-in-time solutions to the Cauchy problem, when the initial data have sufficiently small Sobolev norms. A major difficulty comes from the fact that the class of conformal Killing fields of Minkowski space is significantly reduced in the presence of a massive scalar field, since the scaling vector field is not conformal Killing for the Klein-Gordon operator. Our method relies on the foliation (of the interior of the light cone) of Minkowski spacetime by hyperboloidal hypersurfaces and uses Lorentz-invariant energy norms. We introduce a frame of vector fields adapted to the hyperboloidal foliation and we establish several key properties: Sobolev and Hardy-type inequalities on hyperboloids, as well as sup-norm estimates, which correspond to the sharp time decay for the wave and the Klein-Gordon equations. These estimates allow us to control interaction terms associated with the curved geometry and the massive field by distinguishing between two levels of regularity and energy growth and by a successive use of our key estimates in order to close a bootstrap argument.

  20. Assessment of soil-gas contamination at building 310 underground storage tank area, Fort Gordon, Georgia, 2010-2011

    USGS Publications Warehouse

    Guimaraes, Wladmir B.; Falls, W. Fred; Caldwell, Andral W.; Ratliff, W. Hagan; Wellborn, John B.; Landmeyer, James E.

    2012-01-01

    Soil gas was assessed for contaminants in the building 310 underground storage tank area adjacent to the Dwight D. Eisenhower Army Medical Center at Ft. Gordon, Georgia, from October 2010 to September 2011. The assessment, which also included the detection of organic compounds in soil gas, provides environmental contamination data to Fort Gordon personnel pursuant to requirements of the Resource Conservation and Recovery Act Part B Hazardous Waste Permit process. The study was conducted by the U.S. Geological Survey, in cooperation with the U.S. Department of the Army Environmental and Natural Resources Management Office of the U.S. Army Signal Center and Fort Gordon. Soil-gas samplers were deployed below land surface at 37 locations in the building 310 underground storage tank area. Soil-gas samplers were deployed in a grid pattern near the storage tank area as well as downslope of the tank area in the direction of groundwater flow toward an unnamed tributary to Butler Creek. Total petroleum hydrocarbons were detected in 35 of the 37 soil-gas samplers at levels above the method detection level, and the combined mass of benzene, toluene, ethylbenzene, and total xylenes were detected above their detection levels in 8 of the 37 samplers. In addition, the combined masses of undecane, tridecane, and pentadecane were detected at or above their method detection levels in 9 of the 37 samplers. Other volatile organic compounds detected above their respective method detection levels were chloroform, 1,2,4-trimethylbenzene, and perchloroethylene. In addition, naphthalene, 2-methyl naphthalene, and 1,2,4-trimethylbenzene were detected below the method detection levels, but above the nondetection level.

  1. Comparison of two reliable analytical methods based on the solutions of fractional coupled Klein-Gordon-Zakharov equations in plasma physics

    NASA Astrophysics Data System (ADS)

    Saha Ray, S.; Sahoo, S.

    2016-07-01

    In this paper, homotopy perturbation transform method and modified homotopy analysis method have been applied to obtain the approximate solutions of the time fractional coupled Klein-Gordon-Zakharov equations. We consider fractional coupled Klein-Gordon-Zakharov equation with appropriate initial values using homotopy perturbation transform method and modified homotopy analysis method. Here we obtain the solution of fractional coupled Klein-Gordon-Zakharov equation, which is obtained by replacing the time derivatives with a fractional derivatives of order α ∈ (1, 2], β ∈ (1, 2]. Through error analysis and numerical simulation, we have compared approximate solutions obtained by two present methods homotopy perturbation transform method and modified homotopy analysis method. The fractional derivatives here are described in Caputo sense.

  2. Organization by Gordon Research Conferences of the 2012 Plasma Processing Science Conference 22-27 July 2012

    SciTech Connect

    Chang, Jane

    2012-07-27

    The 2012 Gordon Research Conference on Plasma Processing Science will feature a comprehensive program that will highlight the most cutting edge scientific advances in plasma science and technology as well as explore the applications of this nonequilibrium medium in possible approaches relative to many grand societal challenges. Fundamental science sessions will focus on plasma kinetics and chemistry, plasma surface interactions, and recent trends in plasma generation and multi-phase plasmas. Application sessions will explore the impact of plasma technology in renewable energy, the production of fuels from renewable feedstocks and carbon dioxide neutral solar fuels (from carbon dioxide and water), and plasma-enabled medicine and sterilization.

  3. A Density Functional Approach to Polarizable Models: A Kim-Gordon-Response Density Interaction Potential for Molecular Simulations

    SciTech Connect

    Tabacchi, G; Hutter, J; Mundy, C

    2005-04-07

    A combined linear response--frozen electron density model has been implemented in a molecular dynamics scheme derived from an extended Lagrangian formalism. This approach is based on a partition of the electronic charge distribution into a frozen region described by Kim-Gordon theory, and a response contribution determined by the instaneous ionic configuration of the system. The method is free from empirical pair-potentials and the parameterization protocol involves only calculations on properly chosen subsystems. They apply this method to a series of alkali halides in different physical phases and are able to reproduce experimental structural and thermodynamic properties with an accuracy comparable to Kohn-Sham density functional calculations.

  4. Time exponential splitting technique for the Klein-Gordon equation with Hagstrom-Warburton high-order absorbing boundary conditions

    NASA Astrophysics Data System (ADS)

    Alonso-Mallo, I.; Portillo, A. M.

    2016-04-01

    Klein-Gordon equations on an unbounded domain are considered in one dimensional and two dimensional cases. Numerical computation is reduced to a finite domain by using the Hagstrom-Warburton (H-W) high-order absorbing boundary conditions (ABCs). Time integration is made by means of exponential splitting schemes that are efficient and easy to implement. In this way, it is possible to achieve a negligible error due to the time integration and to study the behavior of the absorption error. Numerical experiments displaying the accuracy of the numerical solution for the two dimensional case are provided. The influence of the dispersion coefficient on the error is also studied.

  5. Global well-posedness and scattering of the (4+1)-dimensional Maxwell-Klein-Gordon equation

    NASA Astrophysics Data System (ADS)

    Oh, Sung-Jin; Tataru, Daniel

    2016-09-01

    This article constitutes the final and main part of a three-paper sequence, whose goal is to prove global well-posedness and scattering of the energy critical Maxwell-Klein-Gordon equation (MKG) on $\\mathbb{R}^{1+4}$ for arbitrary finite energy initial data. Using the successively stronger continuation/scattering criteria established in the previous two papers, we carry out a blow-up analysis and deduce that the failure of global well-posedness and scattering implies the existence of a nontrivial stationary or self-similar solution to MKG. Then, by establishing that such solutions do not exist, we complete the proof.

  6. A numerical scheme and some theoretical aspects for the cylindrically and spherically symmetric sine-Gordon equations

    NASA Astrophysics Data System (ADS)

    Nguyen, Lu Trong Khiem

    2016-07-01

    A finite difference formula based on the predictor-corrector technique is presented to integrate the cylindrically and spherically symmetric sine-Gordon equations numerically. Based on various numerical observations, one property of the waves of kink type is conjectured and used to explain their returning effect. Several numerical experiments are carried out and they are in excellent agreement with the existing results. In addition, the corresponding modulation solution for the two-dimensional ring-shaped kink is extended to that in three-dimension. Both numerical and theoretical aspects are utilized to verify the reliability of the proposed numerical scheme and thus the analytical modulation solutions.

  7. Solutions of the Klein-Gordon equation with the Morse potential energy model in higher spatial dimensions

    NASA Astrophysics Data System (ADS)

    Xie, Xiang-Jun; Jia, Chun-Sheng

    2015-03-01

    We solve the Klein-Gordon equation with the Morse potential energy model to obtain the relativistic bound state energy equation in D spatial dimensions. We find that the inter-dimensional degeneracy symmetry exists for the molecular system represented by the Morse potential model. For a fixed vibrational quantum number and various rotational quantum numbers, the relativistic energies for the X1Σ+ state of the ScI molecule diverge as D increases. We observe that the behavior of the relativistic vibrational energies in higher dimensions remains similar to that of the three-dimensional system.

  8. American Recovery and Reinvestment Act (ARRA) Federal Energy Management Program Technical Assistance Project 282 Renewable Energy Opportunities at Fort Gordon, Georgia

    SciTech Connect

    Boyd, Brian K.; Gorrissen, Willy J.; Hand, James R.; Horner, Jacob A.; Orrell, Alice C.; Russo, Bryan J.; Weimar, Mark R.; Williamson, Jennifer L.; Nesse, Ronald J.

    2010-09-30

    This document provides an overview of renewable resource potential at Fort Gordon, based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. This effort focuses on grid-connected generation of electricity from renewable energy sources and also on ground source heat pumps for heating and cooling buildings. The effort was funded by the American Recovery and Reinvestment Act (ARRA) as follow-on to the 2005 Department of Defense (DoD) Renewables Assessment. The site visit to Fort Gordon took place on March 9, 2010.

  9. Assessment of Soil-Gas and Soil Contamination at the Former Military Police Range, Fort Gordon, Georgia, 2009-2010

    USGS Publications Warehouse

    Falls, W. Fred; Caldwell, Andral W.; Guimaraes, Wladmir B.; Ratliff, W. Hagan; Wellborn, John B.; Landmeyer, James E.

    2011-01-01

    Soil gas and soil were assessed for organic and inorganic contaminants at the former military police range at Fort Gordon, Georgia, from May to September 2010. The assessment evaluated organic contaminants in soil-gas samplers and inorganic contaminants in soil samples. This assessment was conducted to provide environmental contamination data to Fort Gordon pursuant to requirements of the Resource Conservation and Recovery Act Part B Hazardous Waste Permit process. Soil-gas samplers deployed and collected from May 20 to 24, 2010, identified masses above method detection level for total petroleum hydrocarbons, gasoline-related and diesel-related compounds, and chloroform. Most of these detections were in the southwestern quarter of the study area and adjacent to the road on the eastern boundary of the site. Nine of the 11 chloroform detections were in the southern half of the study area. One soil-gas sampler deployed adjacent to the road on the southern boundary of the site detected a mass of tetrachloroethene greater than, but close to, the method detection level of 0.02 microgram. For soil-gas samplers deployed and collected from September 15 to 22, 2010, none of the selected organic compounds classified as chemical agents and explosives were detected above method detection levels. Inorganic concentrations in the five soil samples collected at the site did not exceed the U.S. Environmental Protection Agency regional screening levels for industrial soil and were at or below background levels for similar rocks and strata in South Carolina.

  10. Hydrodynamic representation of the Klein-Gordon-Einstein equations in the weak field limit: General formalism and perturbations analysis

    NASA Astrophysics Data System (ADS)

    Suárez, Abril; Chavanis, Pierre-Henri

    2015-07-01

    Using a generalization of the Madelung transformation, we derive the hydrodynamic representation of the Klein-Gordon-Einstein equations in the weak field limit. We consider a complex self-interacting scalar field with a λ |φ |4 potential. We study the evolution of the spatially homogeneous background in the fluid representation and derive the linearized equations describing the evolution of small perturbations in a static and in an expanding Universe. We compare the results with simplified models in which the gravitational potential is introduced by hand in the Klein-Gordon equation, and assumed to satisfy a (generalized) Poisson equation. Nonrelativistic hydrodynamic equations based on the Schrödinger-Poisson equations or on the Gross-Pitaevskii-Poisson equations are recovered in the limit c →+∞. We study the evolution of the perturbations in the matter era using the nonrelativistic limit of our formalism. Perturbations whose wavelength is below the Jeans length oscillate in time while perturbations whose wavelength is above the Jeans length grow linearly with the scale factor as in the cold dark matter model. The growth of perturbations in the scalar field model is substantially faster than in the cold dark matter model. When the wavelength of the perturbations approaches the cosmological horizon (Hubble length), a relativistic treatment is mandatory. In that case, we find that relativistic effects attenuate or even prevent the growth of perturbations. This paper exposes the general formalism and provides illustrations in simple cases. Other applications of our formalism will be considered in companion papers.

  11. Quantization of the linearized Einstein-Klein-Gordon system on arbitrary backgrounds and the special case of perturbations in inflation

    NASA Astrophysics Data System (ADS)

    Hack, Thomas-Paul

    2014-11-01

    We quantize the linearized Einstein-Klein-Gordon system on arbitrary on-shell backgrounds in a manifestly covariant and gauge-invariant manner. For the special case of perturbations in inflation, i.e. on-shell backgrounds of Friedmann-Lemaître-Robertson-Walker type, we compare our general quantization construction with the standard approach to the quantum theory of perturbations in inflation. We find that not all local quantum observables of the linearized Einstein-Klein-Gordon system can be split into local observables of scalar and tensor type as in the standard approach. However, we argue that this subclass of observables is sufficient for measuring perturbations that vanish at spatial infinity, which is in line with standard assumptions. Finally, we comment on a recent observation that, upon standard quantization, the quantum Bardeen potentials display a non-local behaviour and argue that a similar phenomenon occurs in any local quantum field theory. It is the hope of the author that the present work may constitute a bridge between the generally applicable and thus powerful framework of algebraic quantum field theory in curved spacetimes and the standard treatment of perturbations in inflation.

  12. 2009 Plant Cell Walls Gordon Research Conference-August 2-7,2009

    SciTech Connect

    Debra Mohnen

    2009-08-07

    Plant cell walls are a complex cellular compartment essential for plant growth, development and response to biotic and abiotic stress and a major biological resource for meeting our future bioenergy and natural product needs. The goal of the 2009 Plant Cell Walls Gordon Research Conference is to summarize and critically evaluate the current level of understanding of the structure, synthesis and function of the whole plant extracellular matrix, including the polysaccharides, proteins, lignin and waxes that comprise the wall, and the enzymes and regulatory proteins that drive wall synthesis and modification. Innovative techniques to study how both primary and secondary wall polymers are formed and modified throughout plant growth will be emphasized, including rapid advances taking place in the use of anti-wall antibodies and carbohydrate binding proteins, comparative and evolutionary wall genomics, and the use of mutants and natural variants to understand and identify wall structure-function relationships. Discussions of essential research advances needed to push the field forward toward a systems biology approach will be highlighted. The meeting will include a commemorative lecture in honor of the career and accomplishments of the late Emeritus Professor Bruce A. Stone, a pioneer in wall research who contributed over 40 years of outstanding studies on plant cell wall structure, function, synthesis and remodeling including emphasis on plant cell wall beta-glucans and arabinogalactans. The dwindling supply of fossil fuels will not suffice to meet our future energy and industrial product needs. Plant biomass is the renewable resource that will fill a large part of the void left by vanishing fossil fuels. It is therefore critical that basic research scientists interact closely with industrial researchers to critically evaluate the current state of knowledge regarding how plant biomass, which is largely plant cell walls, is synthesized and utilized by the plant. A final

  13. TU-C-BRE-05: Clinical Implications of AAA Commissioning Errors and Ability of Common Commissioning ' Credentialing Procedures to Detect Them

    SciTech Connect

    McVicker, A; Oldham, M; Yin, F; Adamson, J

    2014-06-15

    Purpose: To test the ability of the TG-119 commissioning process and RPC credentialing to detect errors in the commissioning process for a commercial Treatment Planning System (TPS). Methods: We introduced commissioning errors into the commissioning process for the Anisotropic Analytical Algorithm (AAA) within the Eclipse TPS. We included errors in Dosimetric Leaf Gap (DLG), electron contamination, flattening filter material, and beam profile measurement with an inappropriately large farmer chamber (simulated using sliding window smoothing of profiles). We then evaluated the clinical impact of these errors on clinical intensity modulated radiation therapy (IMRT) plans (head and neck, low and intermediate risk prostate, mesothelioma, and scalp) by looking at PTV D99, and mean and max OAR dose. Finally, for errors with substantial clinical impact we determined sensitivity of the RPC IMRT film analysis at the midpoint between PTV and OAR using a 4mm distance to agreement metric, and of a 7% TLD dose comparison. We also determined sensitivity of the 3 dose planes of the TG-119 C-shape IMRT phantom using gamma criteria of 3% 3mm. Results: The largest clinical impact came from large changes in the DLG with a change of 1mm resulting in up to a 5% change in the primary PTV D99. This resulted in a discrepancy in the RPC TLDs in the PTVs and OARs of 7.1% and 13.6% respectively, which would have resulted in detection. While use of incorrect flattening filter caused only subtle errors (<1%) in clinical plans, the effect was most pronounced for the RPC TLDs in the OARs (>6%). Conclusion: The AAA commissioning process within the Eclipse TPS is surprisingly robust to user error. When errors do occur, the RPC and TG-119 commissioning credentialing criteria are effective at detecting them; however OAR TLDs are the most sensitive despite the RPC currently excluding them from analysis.

  14. The d'--d--d' vertical triad is less discriminating than the a'--a--a' vertical triad in the antiparallel coiled-coil dimer motif.

    PubMed

    Steinkruger, Jay D; Bartlett, Gail J; Hadley, Erik B; Fay, Lindsay; Woolfson, Derek N; Gellman, Samuel H

    2012-02-01

    Elucidating relationships between the amino-acid sequences of proteins and their three-dimensional structures, and uncovering non-covalent interactions that underlie polypeptide folding, are major goals in protein science. One approach toward these goals is to study interactions between selected residues, or among constellations of residues, in small folding motifs. The α-helical coiled coil has served as a platform for such studies because this folding unit is relatively simple in terms of both sequence and structure. Amino acid side chains at the helix-helix interface of a coiled coil participate in so-called "knobs-into-holes" (KIH) packing whereby a side chain (the knob) on one helix inserts into a space (the hole) generated by four side chains on a partner helix. The vast majority of sequence-stability studies on coiled-coil dimers have focused on lateral interactions within these KIH arrangements, for example, between an a position on one helix and an a' position of the partner in a parallel coiled-coil dimer, or between a--d' pairs in an antiparallel dimer. More recently, it has been shown that vertical triads (specifically, a'--a--a' triads) in antiparallel dimers exert a significant impact on pairing preferences. This observation provides impetus for analysis of other complex networks of side-chain interactions at the helix-helix interface. Here, we describe a combination of experimental and bioinformatics studies that show that d'--d--d' triads have much less impact on pairing preference than do a'--a--a' triads in a small, designed antiparallel coiled-coil dimer. However, the influence of the d'--d--d' triad depends on the lateral a'--d interaction. Taken together, these results strengthen the emerging understanding that simple pairwise interactions are not sufficient to describe side-chain interactions and overall stability in antiparallel coiled-coil dimers; higher-order interactions must be considered as well.

  15. Complete set of commuting symmetry operators for the Klein-Gordon equation in generalized higher-dimensional Kerr-NUT-(A)dS spacetimes

    SciTech Connect

    Sergyeyev, Artur; Krtous, Pavel

    2008-02-15

    We consider the Klein-Gordon equation in generalized higher-dimensional Kerr-NUT-(A)dS spacetime without imposing any restrictions on the functional parameters characterizing the metric. We establish commutativity of the second-order operators constructed from the Killing tensors found in [J. High Energy Phys. 02 (2007) 004] and show that these operators, along with the first-order operators originating from the Killing vectors, form a complete set of commuting symmetry operators (i.e., integrals of motion) for the Klein-Gordon equation. Moreover, we demonstrate that the separated solutions of the Klein-Gordon equation obtained in [J. High Energy Phys. 02 (2007) 005] are joint eigenfunctions for all of these operators. We also present an explicit form of the zero mode for the Klein-Gordon equation with zero mass. In the semiclassical approximation we find that the separated solutions of the Hamilton-Jacobi equation for geodesic motion are also solutions for a set of Hamilton-Jacobi-type equations which correspond to the quadratic conserved quantities arising from the above Killing tensors.

  16. Title IV-A Works Toward Total Child Development: John B. Gordon Elementary School, 1972-73. Research and Development Report, Volume 7, Number 25, December, 1973.

    ERIC Educational Resources Information Center

    McWilliams, Joyce H.; Wells, Veronica

    Gordon Elementary School had three supplementary programs during 1972-73 which were funded by federal, state, and local monies. Title IV-A is a federally funded program based on a "total family" approach to treating problems of the child and his education. Health, recreation, and physical fitness; remediation; family counseling; cultural…

  17. Strategies for Improving Education in Urban Communities. A Collection of Articles in Honor of Edmund W. Gordon and Maynard C. Reynolds.

    ERIC Educational Resources Information Center

    Wang, Margaret C., Ed.; Walberg, Herbert J., Ed.

    This collection, which was prepared to honor Edmund W. Gordon and Maynard C. Reynolds for their leadership at the Temple University Center for Research in Human Development and Education, represents the work of researchers from the Center on Education in the Inner Cities. It is organized around the four themes of educational resilience, student…

  18. ADHD Subtypes and Co-Occurring Anxiety, Depression, and Oppositional-Defiant Disorder: Differences in Gordon Diagnostic System and Wechsler Working Memory and Processing Speed Index Scores

    ERIC Educational Resources Information Center

    Mayes, Susan Dickerson; Calhoun, Susan L.; Chase, Gary A.; Mink, Danielle M.; Stagg, Ryan E.

    2009-01-01

    Objective: Wechsler Intelligence Scale for Children Freedom-from-Distractibility/Working Memory Index (FDI/WMI), Processing Speed Index (PSI), and Gordon Diagnostic System (GDS) scores in ADHD children were examined as a function of subtype and coexisting anxiety, depression, and oppositional-defiant disorder. Method: Participants were 587…

  19. A note on four-particle form factors of operators {T}_{2n}{T}_{-2n} in the sinh-Gordon model

    NASA Astrophysics Data System (ADS)

    Lashkevich, Michael; Pugai, Yaroslav

    2016-07-01

    The diagonal matrix elements < {θ }1,{θ }2| {T}2n{T}-2n| {θ }1,{θ }2> between two-particle states in the sinh-Gordon model are computed analytically for all integers n\\gt 0. This confirms the proposal [1] by Smirnov and Zamolodchikov for these matrix elements and demonstrates the effectiveness of the algebraic approach to form factors.

  20. On localized long-lived three-dimensional solutions of the nonlinear Klein-Gordon equation with a fractional power potential

    NASA Astrophysics Data System (ADS)

    Ekomasov, E. G.; Salimov, R. K.

    2014-12-01

    The existence of long-lived ( t ˜ 1000) stable spherically symmetric solutions in the form of pulsons has been numerically revealed for a certain class of Klein-Gordon equations. Their average amplitude of oscillations and the frequency of fast oscillation mode do not change during the entire time of calculation.

  1. Ecological characterization of streams, and fish-tissue analysis for mercury and lead at selected locations, Fort Gordon, Georgia, June 1999 to May 2000

    USGS Publications Warehouse

    Gregory, M. Brian; Stamey, Timothy C.; Wellborn, John B.

    2001-01-01

    The U.S. Geological Survey, in cooperation with the Environmental and Natural Resources Management Office of the U.S. Army Signal Center and Fort Gordon, Ga., documented the ecological condition of selected water-bodies on the Fort Gordon military installation from June 1999 to May 2000. This study includes stream-habitat assessments, aquatic invertebrate and fish-community surveys in selected stream reaches, and analyses of mercury and lead concentrations in largemouth bass (Micropterous salmoides) muscle tissue from three impoundments. Assessment surveys indicate lower habitat value scores in some streams draining the more developed areas on Fort Gordon. A small tributary to Butler Creek--which drains parking lots associated with military motor pools and other impervious surfaces--is characterized by moderate levels of bank erosion and excess sediment in the stream channel compared to reference sites. Four other stream reaches are more similar to reference streams in respect to habitat conditions. Invertebrate communities in streams draining these urbanized watersheds are inhabited by 13 to 16 taxa per reach; whereas, 23 and 33 taxa were collected from the two reference stream reaches. Measures of invertebrate abundance, taxa richness, Ephemeroptera, Plecoptera, and Tricoptera Index are lower in streams draining urbanized watersheds. Measures of community similarity also indicate differences between streams draining urbanized areas and reference streams. Streams draining developed areas on Fort Gordon are inhabited by 3 to 10 fish species and included more species regarded as tolerant of degraded water-quality conditions; whereas, the two reference stream reaches support 4 and 10 species, respectively, including one species considered intolerant of degraded water-quality conditions. Mercury was detected in all largemouth bass collected from three impoundments on Fort Gordon. Wet-weight mercury concentrations in fish tissue analyzed from all sites range from 0

  2. 2007 Renewable Energy: Solar Fuels Gordon Research Conference - January 21-26

    SciTech Connect

    Daniel G. Nocera

    2008-02-01

    This Gordon Research Conference seeks to brings together chemists, physicists, materials scientists and biologists to address perhaps the outstanding technical problem of the 21st Century - the efficient, and ultimately economical, storage of energy from carbon-neutral sources. Such an advance would deliver a renewable, environmentally benign energy source for the future. A great technological challenge facing our global future is energy. The generation of energy, the security of its supply, and the environmental consequences of its use are among the world's foremost geopolitical concerns. Fossil fuels - coal, natural gas, and petroleum - supply approximately 90% of the energy consumed today by industrialized nations. An increase in energy supply is vitally needed to bring electric power to the 25% of the world's population that lacks it, to support the industrialization of developing nations, and to sustain economic growth in developed countries. On the geopolitical front, insuring an adequate energy supply is a major security issue for the world, and its importance will grow in proportion to the singular dependence on oil as a primary energy source. Yet, the current approach to energy supply, that of increased fossil fuel exploration coupled with energy conservation, is not scaleable to meet future demands. Rising living standards of a growing world population will cause global energy consumption to increase significantly. Estimates indicate that energy consumption will increase at least two-fold, from our current burn rate of 12.8 TW to 28 - 35 TW by 2050. - U.N. projections indicate that meeting global energy demand in a sustainable fashion by the year 2050 will require a significant fraction of the energy supply to come carbon free sources to stabilize atmospheric carbon dioxide levels at twice the pre-anthropogenic levels. External factors of economy, environment, and security dictate that this global energy need be met by renewable and sustainable sources

  3. Assessment of soil-gas contamination at the 17th Street landfill, Fort Gordon, Georgia, 2011

    USGS Publications Warehouse

    Falls, W. Fred; Caldwell, Andral W.; Guimaraes, Wladmir G.; Ratliff, W. Hagan; Wellborn, John B.; Landmeyer, James E.

    2012-01-01

    Assessments of contaminants in soil gas were conducted in two study areas at Fort Gordon, Georgia, in July and August of 2011 to supplement environmental contaminant data for previous studies at the 17th Street landfill. The two study areas include northern and eastern parts of the 17th Street landfill and the adjacent wooded areas to the north and east of the landfill. These study areas were chosen because of their close proximity to the surface water in Wilkerson Lake and McCoys Creek. A total of 48 soil-gas samplers were deployed for the July 28 to August 3, 2011, assessment in the eastern study area. The assessment mostly identified detections of total petroleum hydrocarbons (TPH), and gasoline- and diesel-range compounds, but also identified the presence of chlorinated solvents in six samplers, chloroform in three samplers, 2-methyl naphthalene in one sampler, and trimethylbenzene in one sampler. The TPH masses exceeded 0.02 microgram (μg) in all 48 samplers and exceeded 0.9 μg in 24 samplers. Undecane, one of the three diesel-range compounds used to calculate the combined mass for diesel-range compounds, was detected in 17 samplers and is the second most commonly detected compound in the eastern study area, exceeded only by the number of TPH detections. Six samplers had detections of toluene, but other gasoline compounds were detected with toluene in three of the samplers, including detections of ethylbenzene, meta- and para-xylene, and octane. All detections of chlorinated organic compounds had soil-gas masses equal to or less than 0.08 μg, including three detections of trichloroethene, three detections of perchloroethene, three chloroform detections, one 1,4-dichlorobenzene detection, and one 1,1,2-trichloroethane detection. Three methylated compounds were detected in the eastern study area, but were detected at or below method detection levels. A total of 32 soil-gas samplers were deployed for the August 11–24, 2011, assessment in the northern study

  4. ROCK DEFORMATION 2010 GORDON RESEARCH CONFERENCE, AUGUST 8-13, 2010

    SciTech Connect

    David Prior

    2010-08-13

    Creep in the crust and mantle is commonly considered a steady-state process. This view prevails despite the fact that earthquakes do not represent steady-state and at the base of the seismogenic zone, for example, the stresses that drive creep must vary with the earthquake cycle. The contribution of transient versus steady-state behavior is not easy to determine from naturally-deformed brittle or plastic rocks and our view of steady-state depends on whether we consider geological or shorter time-scales. Perhaps we avoid a non steady-state picture because we lack appropriate descriptive or quantitative tools. The aim of the 2010 Gordon Research Conference (GRC) in rock deformation is to explore what we know about non steady-state deformation and how we might advance our understanding through geological and geophysical field investigations, laboratory experiments and modeling. This will require an appraisal of the applicability of steady-state concepts as well as an exploration of transient behavior, in which processes and physical properties cycle between different states as might be the case during earthquake cycles, and transitions in behavior, where finite strain or changing environmental conditions lead to changes in processes and properties. Conference sessions will cover seven broad and interlinked topics. (1) What is steady state?; an appraisal of applicability of the steady-state concept in rock deformation. (2) Seismogenic Faulting and Brittle Fault Rocks; where transience in rates and conditions are accepted but not fully understood. (3) Episodic Creep During the Seismic Cycle; with a focus on processes in areas adjacent to the base of the seismogenic zone. (4) Creep in Zones of Stress and Temperature Cycling; considering deformation in real-world complex systems (5) Deformation, Metamorphism, and Fluids; exploring the interaction of diagenesis/metamorphism and thermal instabilities with deformation. (6) Mechanism and Microstructure Transitions During

  5. 2001 Gordon Research Conference on Quantum Control of Light and Matter. Final progress report [agenda and attendee list

    SciTech Connect

    Shapiro, Moshe

    2001-08-03

    The Gordon Research Conference on Quantum Control of Light and Matter [Quantum Control of Atomic and Molecular Motion] was held at Mount Holyoke College, South Hadley, Massachusetts, July 29 - August 3, 2001. The conference was attended by 119 participants. The attendees represented the spectrum of endeavor in this field, coming from academia, industry, and government laboratories, and included US and foreign scientists, senior researchers, young investigators, and students. Emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate discussion about the key issues in the field today. Session topics included the following: General perspectives, Phase control, Optimal control, Quantum information, Light manipulation and manipulation with light, Control in the condensed phase, Strong field control, Laser cooling and Bose-Einstein Condensate dynamics, and Control in the solid phase.

  6. Quantum signature of discrete breathers in a nonlinear Klein-Gordon lattice with nearest and next-nearest neighbor interactions

    NASA Astrophysics Data System (ADS)

    Tang, Bing; Li, De-Jun

    2016-05-01

    A theoretical work on quantum breathers in a nonlinear Klein-Gordon lattice model with nearest and next-nearest neighbor interactions is presented. The semiclassical and the full quantum cases are respectively considered. For the semiclassical case, we obtain the analytical solution of discrete breather, and find that the wave number corresponding to the appearance of discrete breather changes when the ratio of the next-nearest- to -nearest - neighbor harmonic force constants is greater than 1/4. For the full quantum case, by calculating the energy spectrum of the system containing two quanta, we prove numerically the existence of quantum breathers (two-quanta bound states) and find the shape of energy spectrum changes dramatically as the value of next -nearest neighbor harmonic force constant increasing.

  7. Four five-parametric and five four-parametric independent confluent Heun potentials for the stationary Klein-Gordon equation

    NASA Astrophysics Data System (ADS)

    Tarloyan, A. S.; Ishkhanyan, T. A.; Ishkhanyan, A. M.

    2016-04-01

    We present in total fifteen potentials for which the stationary Klein-Gordon equation is solvable in terms of the confluent Heun functions. Because of the symmetry of the confluent Heun equation with respect to the transposition of its regular singularities, only nine of the potentials are independent. Four of these independent potentials are five-parametric. One of them possesses a four-parametric ordinary hypergeometric sub-potential, another one possesses a four-parametric confluent hypergeometric sub-potential, and one potential possesses four-parametric sub-potentials of both hypergeometric types. The fourth five-parametric potential has a three-parametric confluent hypergeometric sub-potential, which is, however, only conditionally integrable. The remaining five independent Heun potentials are four-parametric and have solutions only in terms of irreducible confluent Heun functions.

  8. 2011 Dynamics at Surfaces Gordon Research Conference (August 7-12, 2011, Salve Regina University, Newport, Rhode Island)

    SciTech Connect

    Greg Sitz

    2011-08-12

    The 2011 Gordon Conference on Dynamics at Surfaces is the 32nd anniversary of a meeting held every two years that is attended by leading researchers in the area of experimental and theoretical dynamics at liquid and solid surfaces. The conference focuses on the dynamics of the interaction of molecules with either liquid or solid surfaces, the dynamics of the outermost layer of liquid and solid surfaces and the dynamics at the liquid-solid interface. Specific topics that are featured include state-to-state scattering dynamics, chemical reaction dynamics, non-adiabatic effects in reactive and inelastic scattering of molecules from surfaces, single molecule dynamics at surfaces, surface photochemistry, ultrafast dynamics at surfaces, and dynamics at water interfaces. The conference brings together investigators from a variety of scientific disciplines including chemistry, physics, materials science, geology, biophysics, and astronomy.

  9. Quantity and quality of stormwater collected from selected stormwater outfalls at industrial sites, Fort Gordon, Georgia, 2011

    USGS Publications Warehouse

    Nagle, Doug D.; Guimaraes, Wladmir B.

    2012-01-01

    An assessment of the quantity and quality of stormwater runoff associated with industrial activities at Fort Gordon was conducted from January through December 2011. The assessment was provided to satisfy the requirements from a general permit that authorizes the discharge of stormwater under the National Pollutant Discharge Elimination System from a site associated with industrial activities. The stormwater quantity refers to the runoff discharge at the point and time of the runoff sampling. The study was conducted by the U.S. Geological Survey, in cooperation with the U.S. Department of the Army Environmental and Natural Resources Management Office of the U.S. Army Signal Center and Fort Gordon. The initial scope of this study was to sample stormwater runoff from five stations at four industrial sites (two landfills and two heating and cooling sites). As a consequence of inadequate hydrologic conditions during 2011, no samples were collected at the two landfills; however, three samples were collected from the heating and cooling sites. The assessment included the collection of physical properties, such as water temperature, specific conductance, dissolved oxygen, and pH; the detection of suspended materials (total suspended solids, total fixed solids, total volatile solids), nutrients and organic compounds, and major and trace inorganic compounds (metals); and the detection of volatile and semivolatile organic compounds. Nutrients and organic compounds, major and trace inorganic compounds, and volatile and semivolatile organic compounds were detected above the laboratory reporting levels in all samples collected from the three stations. The detection of volatile and semivolatile organic compounds included anthracene, benzo[a]anthracene, benzo[a]pyrene, benzo[ghi]perylene, cis,1, 2-dichloroethene, dimethyl phthalate, fluoranthene, naphthalene, pyrene, acenaphthylene (station SWR11-3), and di-n-butyl phthalate (station SWR11-4).

  10. MHC class I antigen presentation of DRiP-derived peptides from a model antigen is not dependent on the AAA ATPase p97.

    PubMed

    Palmer, Amy L; Dolan, Brian P

    2013-01-01

    CD8(+) T cells are responsible for killing cells of the body that have become infected or oncogenically transformed. In order to do so, effector CD8(+) T cells must recognize their cognate antigenic peptide bound to a MHC class I molecule that has been directly presented by the target cell. Due to the rapid nature of antigen presentation, it is believed that antigenic peptides are derived from a subset of newly synthesized proteins which are degraded almost immediately following synthesis and termed Defective Ribosomal Products or DRiPs. We have recently reported on a bioassay which can distinguish antigen presentation of DRiP substrates from other forms of rapidly degraded proteins and found that poly-ubiquitin chain disassembly may be necessary for efficient DRiP presentation. The AAA ATPase p97 protein is necessary for efficient cross-presentation of antigens on MHC class I molecules and plays an important role in extracting mis-folded proteins from the endoplasmic reticulum. Here, we find that genetic ablation or chemical inhibition of p97 does not diminish DRiP antigen presentation to any great extent nor does it alter the levels of MHC class I molecules on the cell surface, despite our observations that p97 inhibition increased the levels of poly-ubiquitinated proteins in the cell. These data demonstrate that inhibiting poly-ubiquitin chain disassembly alone is insufficient to abolish DRiP presentation.

  11. Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates.

    PubMed

    Martin, Andreas; Baker, Tania A; Sauer, Robert T

    2008-02-29

    ClpX, an archetypal proteolytic AAA+ unfoldase, must engage the ssrA tags of appropriate substrates prior to ATP-dependent unfolding and translocation of the denatured polypeptide into ClpP for degradation. Here, specificity-transplant and disulfide-crosslinking experiments reveal that the ssrA tag interacts with different loops that form the top, middle, and lower portions of the central channel of the ClpX hexamer. Our results support a two-step binding mechanism, in which the top loop serves as a specificity filter and the remaining loops form a binding site for the peptide tag relatively deep within the pore. Crosslinking experiments suggest a staggered arrangement of pore loops in the hexamer and nucleotide-dependent changes in pore-loop conformations. This mechanism of initial tag binding would allow ATP-dependent conformational changes in one or more pore loops to drive peptide translocation, force unfolding, and mediate threading of the denatured protein through the ClpX pore.

  12. Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome.

    PubMed

    Gillette, Thomas G; Kumar, Brajesh; Thompson, David; Slaughter, Clive A; DeMartino, George N

    2008-11-14

    The 26 S proteasome is an energy-dependent protease that degrades proteins modified with polyubiquitin chains. It is assembled from two multi-protein subcomplexes: a protease (20 S proteasome) and an ATPase regulatory complex (PA700 or 19 S regulatory particle) that contains six different AAA family subunits (Rpt1 to -6). Here we show that binding of PA700 to the 20 S proteasome is mediated by the COOH termini of two (Rpt2 and Rpt5) of the six Rpt subunits that constitute the interaction surface between the subcomplexes. COOH-terminal peptides of either Rpt2 or Rpt5 bind to the 20 S proteasome and activate hydrolysis of short peptide substrates. Simultaneous binding of both COOH-terminal peptides had additive effects on peptide substrate hydrolysis, suggesting that they bind to distinct sites on the proteasome. In contrast, only the Rpt5 peptide activated hydrolysis of protein substrates. Nevertheless, the COOH-terminal peptide of Rpt2 greatly enhanced this effect, suggesting that proteasome activation is a multistate process. Rpt2 and Rpt5 COOH-terminal peptides cross-linked to different but specific subunits of the 20 S proteasome. These results reveal critical roles of COOH termini of Rpt subunits of PA700 in the assembly and activation of eukaryotic 26 S proteasome. Moreover, they support a model in which Rpt subunits bind to dedicated sites on the proteasome and play specific, nonequivalent roles in the asymmetric assembly and activation of the 26 S proteasome.

  13. Identification of an AAA ATPase VPS4B-Dependent Pathway That Modulates Epidermal Growth Factor Receptor Abundance and Signaling during Hypoxia

    PubMed Central

    Lin, H. Helen; Li, Xu; Chen, Jo-Lin; Sun, Xiuzhu; Cooper, Fariba Norouziyan; Chen, Yun-Ru; Zhang, Wenyu; Chung, Yiyin; Li, Angela; Cheng, Chun-Ting; Yang, Lixin; Deng, XuTao; Liu, Xiyong; Yen, Yun; Johnson, Deborah L.; Shih, Hsiu-Ming; Yang, Austin

    2012-01-01

    VPS4B, an AAA ATPase (ATPase associated with various cellular activities), participates in vesicular trafficking and autophagosome maturation in mammalian cells. In solid tumors, hypoxia is a common feature and an indicator of poor treatment outcome. Our studies demonstrate that exogenous or endogenous (assessed with anchorage-independent three-dimensional multicellular spheroid culture) hypoxia induces VPS4B downregulation by the ubiquitin-proteasome system. Inhibition of VPS4B function by short hairpin VPS4B (sh-VPS4B) or expression of dominant negative VPS4B(E235Q) promotes anchorage-independent breast cancer cell growth and resistance to gefitinib, U0126, and genotoxicity. Biochemically, hyperactivation of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase essential for cell proliferation and survival, accompanied by increased EGFR accumulation and altered intracellular compartmentalization, is observed in cells with compromised VPS4B. Furthermore, enhanced FOS/JUN induction and AP-1 promoter activation are noted in EGF-treated cells with VPS4B knockdown. However, VPS4B depletion does not affect EGFRvIII stability or its associated signaling. An inverse correlation between VPS4B expression and EGFR abundance is observed in breast tumors, and high-grade or recurrent breast carcinomas exhibit lower VPS4B expression. Together, our findings highlight a potentially critical role of VPS4B downregulation or chronic-hypoxia-induced VPS4B degradation in promoting tumor progression, unveiling a nongenomic mechanism for EGFR overproduction in human breast cancer. PMID:22252323

  14. Effects of the changes in the wall shear stresses (WSS) acting on endothelial cells (EC) during the enlargement of Abdominal Aortic Aneurysms (AAA)

    NASA Astrophysics Data System (ADS)

    Salsac, Anne-Virginie

    2005-03-01

    The changes in the spatial and temporal distribution of the WSS and gradients of WSS during the enlargement of AAAs are important to understand the etiology and progression of this vascular disease, since they affect the wall structural integrity, primarily via the changes induced on the shape, functions and metabolism of the endothelial cells. PIV measurements were performed in aneurysm models, while changing systematically their size and geometry. Two regions with distinct patterns of WSS were identified. The region of flow detachment extends over the proximal half and is characterized by oscillatory WSS of very low mean. The region of flow reattachment, located distally, is dominated by large, negative WSS and sustained gradients of WSS that result from the impact of the vortex ring on the wall. Cultured EC were subjected to these two types of stimuli in vitro. The permeability of the endothelium was found to be largely increased in the flow detachment region. Endothelium cell-cell adhesion, proliferation and apoptosis were also affected by the high gradients of WSS.

  15. Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases

    PubMed Central

    Rajendra, Eeson; Garaycoechea, Juan I.; Patel, Ketan J.; Passmore, Lori A.

    2014-01-01

    Fanconi anaemia (FA) is a genome instability disease caused by defects in the FA DNA repair pathway that senses and repairs damage caused by DNA interstrand crosslinks. At least 8 of the 16 genes found mutated in FA encode proteins that assemble into the FA core complex, a multisubunit monoubiquitin E3 ligase. Here, we show that the RuvBL1 and RuvBL2 AAA+ ATPases co-purify with FA core complex isolated under stringent but native conditions from a vertebrate cell line. Depletion of the RuvBL1-RuvBL2 complex in human cells causes hallmark features of FA including DNA crosslinker sensitivity, chromosomal instability and defective FA pathway activation. Genetic knockout of RuvBL1 in a murine model is embryonic lethal while conditional inactivation in the haematopoietic stem cell pool confers profound aplastic anaemia. Together these findings reveal a function for RuvBL1-RuvBL2 in DNA repair through a physical and functional association with the FA core complex. Surprisingly, depletion of RuvBL1-RuvBL2 leads to co-depletion of the FA core complex in human cells. This suggests that a potential mechanism for the role of RuvBL1-RuvBL2 in maintaining genome integrity is through controlling the cellular abundance of FA core complex. PMID:25428364

  16. Engagement of Arginine Finger to ATP Triggers Large Conformational Changes in NtrC1 AAA+ ATPase for Remodeling Bacterial RNA Polymerase

    SciTech Connect

    Chen, Baoyu; Sysoeva, Tatyana A.; Chowdhury, Saikat; Guo, Liang; De Carlo, Sacha; Hanson, Jeffrey A.; Yang, Haw; Nixon, B. Tracy

    2010-11-19

    The NtrC-like AAA+ ATPases control virulence and other important bacterial activities through delivering mechanical work to {sigma}54-RNA polymerase to activate transcription from {sigma}54-dependent genes. We report the first crystal structure for such an ATPase, NtrC1 of Aquifex aeolicus, in which the catalytic arginine engages the {gamma}-phosphate of ATP. Comparing the new structure with those previously known for apo and ADP-bound states supports a rigid-body displacement model that is consistent with large-scale conformational changes observed by low-resolution methods. First, the arginine finger induces rigid-body roll, extending surface loops above the plane of the ATPase ring to bind {sigma}54. Second, ATP hydrolysis permits Pi release and retraction of the arginine with a reversed roll, remodeling {sigma}54-RNAP. This model provides a fresh perspective on how ATPase subunits interact within the ring-ensemble to promote transcription, directing attention to structural changes on the arginine-finger side of an ATP-bound interface.

  17. Identification of novel biomarkers of abdominal aortic aneurysms by 2D-DIGE and MALDI-MS from AAA-thrombus-conditioned media.

    PubMed

    Martinez-Pinna, Roxana; Lopez, Juan Antonio; Ramos-Mozo, Priscila; Blanco-Colio, Luis M; Camafeita, Emilio; Calvo, Enrique; Meilhac, Olivier; Michel, Jean Baptiste; Egido, Jesús; Martin-Ventura, José Luis

    2013-01-01

    In the search for novel biomarkers, noncandidate-based proteomic strategies open up new opportunities to gain a deeper insight into disease processes regarding their molecular mechanisms, the risk factors involved, and the monitoring of disease progression. To carry out these complex analyses, the combined use of gel electrophoresis with mass spectrometry (MS) represents a powerful choice. In addition, the introduction of protein dye labeling has notably improved the reliability of differential expression studies by increasing the statistical significance of the protein candidates. Here, we describe a strategy where different layers (luminal/abluminal) from the intraluminal thrombus (ILT) of human abdominal aortic aneurysm (AAA) patients were incubated in protein-free medium. Then, the levels of the proteins released were compared by two-dimensional differential in-gel electrophoresis (2D-DIGE) and the proteins of interest identified by MS. We consider that the use of tissue-conditioned media could offer a substantial advantage in the analytical study of biological fluids, as they provide a source of proteins to be released to the bloodstream, which could serve as potential circulating biomarkers.

  18. When symptom is symbol: some comments on Rosemary Gordon's, 'Masochism: the shadow side of the archetypal need to venerate and worship'.

    PubMed

    Stein, Murray

    2015-09-01

    This paper is a commentary on Rosemary Gordon's paper, 'Masochism: the shadow side of the archetypal need to venerate and worship', with a suggestion for an alternative interpretation of masochism as a part of a sado-masochistic couple. Gordon postulates an archetypal need to venerate and worship that can be hidden in the shadow and distorted in such practices as sexual masochism. Her paper also offers several avenues of exploration for further studies in connection with the phenomenon of masochism, including sexual perversion ('paraphilia'), chronic psychological victimhood, PTSD and traumatology, religious extremist behaviour such as self-flagellation, transformation in the individuation process and numinous experience. An extension of her hypothesis to include religious problems of modernity is suggested. PMID:26274850

  19. When symptom is symbol: some comments on Rosemary Gordon's, 'Masochism: the shadow side of the archetypal need to venerate and worship'.

    PubMed

    Stein, Murray

    2015-09-01

    This paper is a commentary on Rosemary Gordon's paper, 'Masochism: the shadow side of the archetypal need to venerate and worship', with a suggestion for an alternative interpretation of masochism as a part of a sado-masochistic couple. Gordon postulates an archetypal need to venerate and worship that can be hidden in the shadow and distorted in such practices as sexual masochism. Her paper also offers several avenues of exploration for further studies in connection with the phenomenon of masochism, including sexual perversion ('paraphilia'), chronic psychological victimhood, PTSD and traumatology, religious extremist behaviour such as self-flagellation, transformation in the individuation process and numinous experience. An extension of her hypothesis to include religious problems of modernity is suggested.

  20. Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24

    PubMed Central

    Agler, Caryline; Nielsen, Dahlia M.; Urkasemsin, Ganokon; Singleton, Andrew; Tonomura, Noriko; Sigurdsson, Snaevar; Tang, Ruqi; Linder, Keith; Arepalli, Sampath; Hernandez, Dena; Lindblad-Toh, Kerstin; van de Leemput, Joyce; Motsinger-Reif, Alison; O'Brien, Dennis P.; Bell, Jerold; Harris, Tonya; Steinberg, Steven; Olby, Natasha J.

    2014-01-01

    Old English Sheepdogs and Gordon Setters suffer from a juvenile onset, autosomal recessive form of canine hereditary ataxia primarily affecting the Purkinje neuron of the cerebellar cortex. The clinical and histological characteristics are analogous to hereditary ataxias in humans. Linkage and genome-wide association studies on a cohort of related Old English Sheepdogs identified a region on CFA4 strongly associated with the disease phenotype. Targeted sequence capture and next generation sequencing of the region identified an A to C single nucleotide polymorphism (SNP) located at position 113 in exon 1 of an autophagy gene, RAB24, that segregated with the phenotype. Genotyping of six additional breeds of dogs affected with hereditary ataxia identified the same polymorphism in affected Gordon Setters that segregated perfectly with phenotype. The other breeds tested did not have the polymorphism. Genome-wide SNP genotyping of Gordon Setters identified a 1.9 MB region with an identical haplotype to affected Old English Sheepdogs. Histopathology, immunohistochemistry and ultrastructural evaluation of the brains of affected dogs from both breeds identified dramatic Purkinje neuron loss with axonal spheroids, accumulation of autophagosomes, ubiquitin positive inclusions and a diffuse increase in cytoplasmic neuronal ubiquitin staining. These findings recapitulate the changes reported in mice with induced neuron-specific autophagy defects. Taken together, our results suggest that a defect in RAB24, a gene associated with autophagy, is highly associated with and may contribute to canine hereditary ataxia in Old English Sheepdogs and Gordon Setters. This finding suggests that detailed investigation of autophagy pathways should be undertaken in human hereditary ataxia. PMID:24516392