Science.gov

Sample records for 4232-dcc hints briefs

  1. Hints.

    PubMed

    Abu-Mostafa, Y S

    1995-07-01

    The systematic use of hints in the learning-from-examples paradigm is the subject of this review. Hints are the properties of the target function that are known to use independently of the training examples. The use of hints is tantamount to combining rules and data in learning, and is compatible with different learning models, optimization techniques, and regularization techniques. The hints are represented to the learning process by virtual examples, and the training examples of the target function are treated on equal footing with the rest of the hints. A balance is achieved between the information provided by the different hints through the choice of objective functions and learning schedules. The Adaptive Minimization algorithm achieves this balance by relating the performance on each hint to the overall performance. The application of hints in forecasting the very noisy foreign-exchange markets is illustrated. On the theoretical side, the information value of hints is contrasted to the complexity value and related to the VC dimension.

  2. HINTS Puerto Rico: Final Report

    Cancer.gov

    This final report describes HINTS implementation in Puerto Rico. The report addresses sampling; staffing, training and management of data collection; calling protocol; findings from the CATI Operations, and sample weights.

  3. Active Learning Using Hint Information.

    PubMed

    Li, Chun-Liang; Ferng, Chun-Sung; Lin, Hsuan-Tien

    2015-08-01

    The abundance of real-world data and limited labeling budget calls for active learning, an important learning paradigm for reducing human labeling efforts. Many recently developed active learning algorithms consider both uncertainty and representativeness when making querying decisions. However, exploiting representativeness with uncertainty concurrently usually requires tackling sophisticated and challenging learning tasks, such as clustering. In this letter, we propose a new active learning framework, called hinted sampling, which takes both uncertainty and representativeness into account in a simpler way. We design a novel active learning algorithm within the hinted sampling framework with an extended support vector machine. Experimental results validate that the novel active learning algorithm can result in a better and more stable performance than that achieved by state-of-the-art algorithms. We also show that the hinted sampling framework allows improving another active learning algorithm designed from the transductive support vector machine.

  4. Hints to blood groupers, 1950.

    PubMed

    Schmidt, Paul J; Greenwalt, Tibor J

    2006-03-01

    Sixty years ago, the premier blood grouping laboratory was that of Robert Race in London. Agglutination tests and blood grouping had provided breakthroughs in immunology, genetics, and the solution of clinical problems. The significance of immunohematology was recognized by the clinical hematology community as a potent force in the expanding field of disorders of the blood and blood-forming organs. The instructions by Race to his London workers entitled Hints to Blood Groupers provide a picture of the immunohematology laboratory even before automation and differed slightly from the American techniques that derived from Landsteiner. Before agglutination is replaced in the near future by the emergence of molecular methods, the detailed method of a superb laboratory is recorded.

  5. Enhancing the Automatic Generation of Hints with Expert Seeding

    ERIC Educational Resources Information Center

    Stamper, John; Barnes, Tiffany; Croy, Marvin

    2011-01-01

    The Hint Factory is an implementation of our novel method to automatically generate hints using past student data for a logic tutor. One disadvantage of the Hint Factory is the time needed to gather enough data on new problems in order to provide hints. In this paper we describe the use of expert sample solutions to "seed" the hint generation…

  6. Enhancing the Automatic Generation of Hints with Expert Seeding

    ERIC Educational Resources Information Center

    Stamper, John; Barnes, Tiffany; Croy, Marvin

    2011-01-01

    The Hint Factory is an implementation of our novel method to automatically generate hints using past student data for a logic tutor. One disadvantage of the Hint Factory is the time needed to gather enough data on new problems in order to provide hints. In this paper we describe the use of expert sample solutions to "seed" the hint generation…

  7. Cosmological hints of modified gravity?

    NASA Astrophysics Data System (ADS)

    Di Valentino, Eleonora; Melchiorri, Alessandro; Silk, Joseph

    2016-01-01

    The recent measurements of cosmic microwave background (CMB) temperature and polarization anisotropies made by the Planck satellite have provided impressive confirmation of the Λ CDM cosmological model. However interesting hints of slight deviations from Λ CDM have been found, including a 95% C.L. preference for a "modified gravity" (MG) structure formation scenario. In this paper we confirm the preference for a modified gravity scenario from Planck 2015 data, find that modified gravity solves the so-called Alens anomaly in the CMB angular spectrum, and constrains the amplitude of matter density fluctuations to σ8=0.81 5-0.048+0.032 , in better agreement with weak lensing constraints. Moreover, we find a lower value for the reionization optical depth of τ =0.059 ±0.020 (to be compared with the value of τ =0.079 ±0.017 obtained in the standard scenario), more consistent with recent optical and UV data. We check the stability of this result by considering possible degeneracies with other parameters, including the neutrino effective number, the running of the spectral index and the amount of primordial helium. The indication for modified gravity is still present at about 95% C.L., and could become more significant if lower values of τ were to be further confirmed by future cosmological and astrophysical data. When the CMB lensing likelihood is included in the analysis the statistical significance for MG simply vanishes, indicating also the possibility of a systematic effect for this MG signal.

  8. Health Hints: Use Caution with Pain Relievers

    MedlinePlus

    ... Resources for You Health Hints: Use Caution with Pain Relievers. Share Tweet Linkedin Pin it More sharing options ... Pin it Email Print PDF version (447KB) (NAPS) -- Pain relievers, when used correctly, are safe and effective. Millions ...

  9. Study Surfaces Helpful Hints for Teachers.

    ERIC Educational Resources Information Center

    Educational R&D Report, 1979

    1979-01-01

    THE FOLLOWING IS THE FULL TEXT OF THIS DOCUMENT Far West Laboratory researchers involved in the Beginning Teacher Evaluation Study contend that increasing Academic Learning Time promotes basic skills achievement among elementary school children. During the course of the six-year study, researchers identified numerous "helpful hints" for…

  10. Study Surfaces Helpful Hints for Teachers.

    ERIC Educational Resources Information Center

    Educational R&D Report, 1979

    1979-01-01

    THE FOLLOWING IS THE FULL TEXT OF THIS DOCUMENT Far West Laboratory researchers involved in the Beginning Teacher Evaluation Study contend that increasing Academic Learning Time promotes basic skills achievement among elementary school children. During the course of the six-year study, researchers identified numerous "helpful hints" for…

  11. Hints on storing timber to prevent decay

    Treesearch

    Forest Products Laboratory

    1919-01-01

    Many serious losses from decay in wooden structures are due to the fact that the timbers used were infected with wood-destroying fungi while in storage. These losses can be greatly reduced by keeping lumber storage yards in a sanitary condition. Some hints as to how to do this are given below.

  12. Interpreting hints for lepton flavor universality violation

    NASA Astrophysics Data System (ADS)

    Altmannshofer, Wolfgang; Stangl, Peter; Straub, David M.

    2017-09-01

    We interpret the recent hints for lepton flavor universality violation in rare B meson decays. Based on a model-independent effective Hamiltonian approach, we determine regions of new physics parameter space that give a good description of the experimental data on RK and RK*, which is in tension with Standard Model predictions. We suggest further measurements that can help narrowing down viable new physics explanations. We stress that the measured values of RK and RK* are fully compatible with new physics explanations of other anomalies in rare B meson decays based on the b →s μ μ transition. If the hints for lepton flavor universality violation are the first signs of new physics, perturbative unitarity implies new phenomena below a scale of ˜100 TeV .

  13. Helpful hints to painless payload processing

    NASA Technical Reports Server (NTRS)

    Terhune, Terry; Carson, Maggie

    1995-01-01

    The helpful hints herein describe, from a system perspective, the functional flow of hardware and software. The flow will begin at the experiment development stage and continue through build-up, test, verification, delivery, launch and deintegration of the experiment. An effort will be made to identify those interfaces and transfer functions of processing that can be improved upon in the new world of 'Faster, Better, and Cheaper.' The documentation necessary to ensure configuration and processing requirements satisfaction will also be discussed. Hints and suggestions for improvements to enhance each phase of the flow will be derived from extensive experience and documented lessons learned. Charts will be utilized to define the functional flow and a list of 'lessons learned' will be addressed to show applicability. In conclusion, specific improvements for several areas of hardware processing, procedure development and quality assurance, that are generic to all Small Payloads, will be identified.

  14. Data-Driven Hint Generation from Peer Debugging Solutions

    ERIC Educational Resources Information Center

    Liu, Zhongxiu

    2015-01-01

    Data-driven methods have been a successful approach to generating hints for programming problems. However, the majority of previous studies are focused on procedural hints that aim at moving students to the next closest state to the solution. In this paper, I propose a data-driven method to generate remedy hints for BOTS, a game that teaches…

  15. Increased anxiety-related behaviour in Hint1 knockout mice.

    PubMed

    Varadarajulu, Jeeva; Lebar, Maria; Krishnamoorthy, Gurumoorthy; Habelt, Sonja; Lu, Jia; Bernard Weinstein, I; Li, Haiyang; Holsboer, Florian; Turck, Christoph W; Touma, Chadi

    2011-07-07

    Several reports have implicated a role for the histidine triad nucleotide-binding protein-1 (Hint1) in psychiatric disorders. We have studied the emotional behaviour of male Hint1 knockout (Hint1 KO) mice in a battery of tests and performed biochemical analyses on brain tissue. The behavioural analysis revealed that Hint1 KO mice exhibit an increased emotionality phenotype compared to wildtype (WT) mice, while no significant differences in locomotion or general exploratory activity were noted. In the elevated plus-maze (EPM) test, the Hint1 KO animals entered the open arms of the apparatus less often than WT littermates. Similarly, in the dark-light box test, Hint1 KO mice spent less time in the lit compartment and the number of entries were reduced, which further confirmed an increased anxiety-related behaviour. Moreover, the Hint1 KO animals showed significantly more struggling and less floating behaviour in the forced swim test (FST), indicating an increased emotional arousal in aversive situations. Hint1 is known as a protein kinase C (PKC) interacting protein. Western blot analysis showed that PKCγ expression was elevated in Hint1 KO compared to WT mice. Interestingly, PKCγ mRNA levels of the two groups did not show a significant difference, implying a post-transcriptional PKCγ regulation. In addition, PKC enzymatic activity was increased in Hint1 KO compared to WT mice. In summary, our results indicate a role for Hint1 and PKCγ in modulating anxiety-related and stress-coping behaviour in mice.

  16. HINTS 2013 Conference Summaries of Presentations and Posters

    Cancer.gov

    Summaries of Presentations and Poster Abstracts for the HINTS 2013 Conference titled A Decade of HINTS: Quantifying the Health Information Revolution through Data Innovation and Collaboration and held on October 2-3, 2013 at the Natcher building on the NIH campus in Bethesda, MD

  17. Structured hints : extracting and abstracting domain expertise.

    SciTech Connect

    Hereld, M.; Stevens, R.; Sterling, T.; Gao, G. R.; Mathematics and Computer Science; California Inst. of Tech.; Louisiana State Univ.; Univ. of Delaware

    2009-03-16

    We propose a new framework for providing information to help optimize domain-specific application codes. Its design addresses problems that derive from the widening gap between the domain problem statement by domain experts and the architectural details of new and future high-end computing systems. The design is particularly well suited to program execution models that incorporate dynamic adaptive methodologies for live tuning of program performance and resource utilization. This new framework, which we call 'structured hints', couples a vocabulary of annotations to a suite of performance metrics. The immediate target is development of a process by which a domain expert describes characteristics of objects and methods in the application code that would not be readily apparent to the compiler; the domain expert provides further information about what quantities might provide the best indications of desirable effect; and the interactive preprocessor identifies potential opportunities for the domain expert to evaluate. Our development of these ideas is progressing in stages from case study, through manual implementation, to automatic or semi-automatic implementation. In this paper we discuss results from our case study, an examination of a large simulation of a neural network modeled after the neocortex.

  18. Flexible synthesis of video frames based on motion hints.

    PubMed

    Naman, Aous Thabit; Taubman, David

    2014-09-01

    In this paper, we propose the use of "motion hints" to produce interframe predictions. A motion hint is a loose and global description of motion that can be communicated using metadata; it describes a continuous and invertible motion model over multiple frames, spatially overlapping other motion hints. A motion hint provides a reasonably accurate description of motion but only a loose description of where it is applicable; it is the task of the client to identify the exact locations where this motion model is applicable. The focus of this paper is a probabilistic multiscale approach to identifying these locations of applicability; the method is robust to noise, quantization, and contrast changes. The proposed approach employs the Laplacian pyramid; it generates motion hint probabilities from observations at each scale of the pyramid. These probabilities are then combined across the scales of the pyramid starting from the coarsest scale. The computational cost of the approach is reasonable, and only the neighborhood of a pixel is employed to determine a motion hint probability, which makes parallel implementation feasible. This paper also elaborates on how motion hint probabilities are exploited in generating interframe predictions. The scheme of this paper is applicable to closed-loop prediction, but it is more useful in open-loop prediction scenarios, such as using prediction in conjunction with remote browsing of surveillance footage, communicated by a JPEG2000 Interactive Protocol (JPIP) server. We show that the interframe predictions obtained using the proposed approach are good both visually and in terms of PSNR.

  19. Measuring Learning from hints in Web-based Socratic Tutor

    NASA Astrophysics Data System (ADS)

    Lee, Young-Jin; Pritchard, D. E.

    2006-12-01

    We present a study of the usefulness of various hints implemented in a Web-based homework tutor MasteringPhysics. Problem solving skill of students and difficulty of problems were first determined by applying Item Response Theory (IRT) to the first answers of students working on homework problems of an introductory Newtonian physics course. The usefulness of hints were then measured by the changes in their problem solving skill on the second attempt at answering the problems they had previously failed after they went through different learning paths, e.g. using different hints provided by the online tutor. We found that the changes in problem solving skill depended strongly on the learning paths students took. The most effective path (about plus 1.8 standard deviation above untutored expectation) was for students who requested hints and subtasks prior to attempting to answer. They may be displaying metacognitive ability.

  20. 108. Photocopy of frontispiece in Owen, Hints. MAIN ENTRANCE, NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    108. Photocopy of frontispiece in Owen, Hints. MAIN ENTRANCE, NORTH FRONT, SMITHSONIAN INSTITUTION - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  1. 107. Photocopy of plate opposite page 104 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    107. Photocopy of plate opposite page 104 in Owen, Hints. SMITHSONIAN INSTITUTION, FROM THE NORTH-EAST - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  2. 112. Photocopy of plate opposite page 43 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    112. Photocopy of plate opposite page 43 in Owen, Hints. CENTRAL SOUTHERN TOWER, SMITHSONIAN INSTITUTION; FROM THE SOUTH-WEST - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  3. 109. Photocopy of plate opposite page 75 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    109. Photocopy of plate opposite page 75 in Owen, Hints. WEST WING, SMITHSONIAN INSTITUTION: FROM THE NORTH-EAST - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  4. 110. Photocopy of plate opposite page 19 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    110. Photocopy of plate opposite page 19 in Owen, Hints. CAMPANILE, SMITHSONIAN INSTITUTION, FROM THE NORTH-EAST - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  5. 113. Photocopy of illustration on page 109 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    113. Photocopy of illustration on page 109 in Owen, Hints. SOUTHERN GATEWAY, SMITHSONIAN INSTITUTION - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  6. 111. Photocopy of plate opposite page 108 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    111. Photocopy of plate opposite page 108 in Owen, Hints. SMITHSONIAN INSTITUTION FROM THE SOUTH WEST - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  7. 106. Photocopy of plate opposite pge 99 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    106. Photocopy of plate opposite pge 99 in Owen, Hints. GOTHIC DESIGN FOR SMITHSONIAN INSTITUTION - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  8. Axonal neuropathy with neuromyotonia: there is a HINT.

    PubMed

    Peeters, Kristien; Chamova, Teodora; Tournev, Ivailo; Jordanova, Albena

    2017-04-01

    Recessive mutations in the gene encoding the histidine triad nucleotide binding protein 1 (HINT1) were recently shown to cause a motor-predominant Charcot-Marie-Tooth neuropathy. About 80% of the patients exhibit neuromyotonia, a striking clinical and electrophysiological hallmark that can help to distinguish this disease and to guide diagnostic screening. HINT1 neuropathy has worldwide distribution and is particularly prevalent in populations inhabiting central and south-eastern Europe. With 12 different mutations identified in more than 60 families, it ranks among the most common subtypes of axonal Charcot-Marie-Tooth neuropathy. This article provides an overview of the present knowledge on HINT1 neuropathy with the aim to increase awareness and spur interest among clinicians and researchers in the field. We propose diagnostic guidelines to recognize and differentiate this entity and suggest treatment strategies to manage common symptoms. As a recent player in the field of hereditary neuropathies, the role of HINT1 in peripheral nerves is unknown and the underlying disease mechanisms are unexplored. We provide a comprehensive overview of the structural and functional characteristics of the HINT1 protein that may guide further studies into the molecular aetiology and treatment strategies of this peculiar Charcot-Marie-Tooth subtype. © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain.

  9. Axonal neuropathy with neuromyotonia: there is a HINT

    PubMed Central

    Peeters, Kristien; Chamova, Teodora; Tournev, Ivailo

    2017-01-01

    Abstract Recessive mutations in the gene encoding the histidine triad nucleotide binding protein 1 (HINT1) were recently shown to cause a motor-predominant Charcot–Marie–Tooth neuropathy. About 80% of the patients exhibit neuromyotonia, a striking clinical and electrophysiological hallmark that can help to distinguish this disease and to guide diagnostic screening. HINT1 neuropathy has worldwide distribution and is particularly prevalent in populations inhabiting central and south-eastern Europe. With 12 different mutations identified in more than 60 families, it ranks among the most common subtypes of axonal Charcot–Marie–Tooth neuropathy. This article provides an overview of the present knowledge on HINT1 neuropathy with the aim to increase awareness and spur interest among clinicians and researchers in the field. We propose diagnostic guidelines to recognize and differentiate this entity and suggest treatment strategies to manage common symptoms. As a recent player in the field of hereditary neuropathies, the role of HINT1 in peripheral nerves is unknown and the underlying disease mechanisms are unexplored. We provide a comprehensive overview of the structural and functional characteristics of the HINT1 protein that may guide further studies into the molecular aetiology and treatment strategies of this peculiar Charcot–Marie–Tooth subtype. PMID:28007994

  10. Hints from Run 1 and prospects from Run 2 at ATLAS

    SciTech Connect

    Bernius, Catrin

    2016-06-21

    The Large Hadron Collider at CERN has allowed the ATLAS experiment to collect a large amount of proton-proton collision data at 7 TeV and 8 TeV centre-of-mass energies throughout Run 1. This dataset was used to discover a Higgs boson with Standard Model-like properties at a mass of about 125 GeV. Furthermore, an impressive number of searches for deviations from the Standard Model expectations have been carried out. To date, no evidence for new physics beyond the SM has been found. However, a few hints in form of 2-3 σ deviations have been observed. After an 18-month shutdown, in which the ATLAS detector has undergone various upgrades, the LHC has again started to deliver collision data at an increased centre-of-mass energy of 13 TeV, providing a much improved sensitivity for various searches, in particular for high mass particles. Some representative hints at the LHC Run 1 are presented, a brief overview of ATLAS upgrades and prospects for SUSY searches with early Run 2 data are given.

  11. Hints from Run 1 and prospects from Run 2 at ATLAS

    NASA Astrophysics Data System (ADS)

    Bernius, Catrin

    2016-06-01

    The Large Hadron Collider at CERN has allowed the ATLAS experiment to collect a large amount of proton-proton collision data at 7 TeV and 8 TeV centre-of-mass energies throughout Run 1. This dataset was used to discover a Higgs boson with Standard Model-like properties at a mass of about 125 GeV. Furthermore, an impressive number of searches for deviations from the Standard Model expectations have been carried out. To date, no evidence for new physics beyond the SM has been found. However, a few hints in form of 2-3 σ deviations have been observed. After an 18-month shutdown, in which the ATLAS detector has undergone various upgrades, the LHC has again started to deliver collision data at an increased centre-of-mass energy of 13 TeV, providing a much improved sensitivity for various searches, in particular for high mass particles. Some representative hints at the LHC Run 1 are presented, a brief overview of ATLAS upgrades and prospects for SUSY searches with early Run 2 data are given.

  12. An analytical model of the HINT performance metric

    SciTech Connect

    Snell, Q.O.; Gustafson, J.L.

    1996-10-01

    The HINT benchmark was developed to provide a broad-spectrum metric for computers and to measure performance over the full range of memory sizes and time scales. We have extended our understanding of why HINT performance curves look the way they do and can now predict the curves using an analytical model based on simple hardware specifications as input parameters. Conversely, by fitting the experimental curves with the analytical model, hardware specifications such as memory performance can be inferred to provide insight into the nature of a given computer system.

  13. Helpful Hints for School Emergency Management: Emergency "Go-Kits"

    ERIC Educational Resources Information Center

    Hill, Tara

    2006-01-01

    "Helpful Hints" offers a quick overview of school emergency preparedness topics that are frequently the subject of inquiries. The Office of Safe and Drug-Free Schools (OSDFS) encourages schools to consider emergency management in the context of its four phases: mitigation and prevention, preparedness, response, and recovery. The preparedness phase…

  14. Some Field Hints from an Old Top Hand.

    ERIC Educational Resources Information Center

    Muller, Seimon W.

    1983-01-01

    Suggestions for successful geology field trips are provided. These "field hints" focus on geological reasoning; equipment; notes; samples and records; field practices, including mapping; camping; working with associates in the field; and general considerations such as carrying along a few textbooks, finding out about an area before the trip, and…

  15. Study Hints for Learning a Foreign/Second Language.

    ERIC Educational Resources Information Center

    Giauque, Gerald S.

    A list of basic study practices and strategies, with examples and alternatives that focus on both receptive and productive skills and the value in interaction, is presented. The following hints are included: (1) don't study a language by yourself and in silence, but study aloud and with another person; (2) use the target language as much as…

  16. HINTS for differentiating peripheral from central causes of vertigo.

    PubMed

    Jaynstein, Dayna

    2016-10-01

    Dizziness and vertigo are common and difficult complaints encountered by providers. The differential diagnosis is large and varies from benign to life-threatening disorders. The true challenge becomes differentiating benign peripheral vertigo from central vertigo. The HINTS examination can help differentiate peripheral from central causes of dizziness and vertigo.

  17. Hints on the use of the PCMDI Visualization and Computation System (VCS)

    SciTech Connect

    Williams, Dean N.; Drach, R. S.; Mobley, R. L.; Phillips, T. J.

    1995-04-01

    This report documents the Hints interactive displays that assist a user of the PCMDI Visualization and Computation System (VCS). These Hints describe the purpose of the VCS panels and provide basic instructions on their use.

  18. A two-Higgs-doublet model facing experimental hints

    NASA Astrophysics Data System (ADS)

    Crivellin, Andreas; Heeck, Julian; Stoffer, Peter

    2016-04-01

    Physics beyond the Standard Model has so far eluded our experimental probes. Nevertheless, a number of interesting anomalies have accumulated that can be taken as hints towards new physics: BaBar, Belle, and LHCb have found deviations of approximately 3:8σ in B → Dτν and B → D*τν; the anomalous magnetic moment of the muon differs by about 3σ from the theoretic prediction; the branching ratio for τ → μνν is about 2σ above the Standard Model expectation; and CMS and ATLAS found hints for a non-zero decay rate of h → μτ at 2.6σ. Here we consider these processes within a lepton-specific two-Higgs doublet model with additional non-standard Yukawa couplings and show how (and which of) these excesses can be accommodated.

  19. Issue Brief #2: Metrics for Improving Cost Accountability (Hint: Not More Detailed Cost Accounting...)

    ERIC Educational Resources Information Center

    Delta Project on Postsecondary Education Costs, Productivity and Accountability, 2009

    2009-01-01

    Most fiscal reporting focuses on revenues (whether or not they go to core purposes), tuition and fees, and financial aid. "How" the money is spent is something that remains shrouded in too much mystery. Several national efforts to address this problem have largely come to naught--probably because those common methodologies are simultaneously not…

  20. [Peripheral vertigo versus central vertigo. Application of the HINTS protocol].

    PubMed

    Batuecas-Caletrío, Ángel; Yáñez-González, Raquel; Sánchez-Blanco, Carmen; González-Sánchez, Enrique; Benito, José; Gómez, José Carlos; Santa Cruz-Ruiz, Santiago

    2014-10-16

    Introduccion. Uno de los dilemas mas importantes concernientes al vertigo en urgencias es su diagnostico diferencial. Existen signos de alarma de gran sensibilidad en la exploracion que pueden ponernos en la pista de encontrarnos ante un vertigo central. Objetivo. Determinar la eficacia de la aplicacion del protocolo HINTS en el diagnostico del accidente cerebrovascular que simula un vertigo periferico. Pacientes y metodos. Estudio observacional descriptivo sobre pacientes ingresados con diagnostico de sindrome vestibular agudo en urgencias. Todos los pacientes fueron objeto de un seguimiento diario hasta la mejoria de sus sintomas con informacion del nistagmo, la maniobra de impulso oculocefalico y el test de skew. Se comparan los resultados del estudio de resonancia magnetica con la alteracion en alguno de esos tres signos a lo largo del ingreso del enfermo. Resultados. Se reunio a 91 pacientes, con una edad media de 55,8 años. Se objetivo un accidente cerebrovascular en ocho de ellos. De estos (edad media: 71 años), en siete existia una alteracion en alguno de los signos HINTS y en uno el estudio fue normal (sensibilidad: 0,88; especificidad: 0,96). Todos ellos tenian algun factor de riesgo vascular. Conclusiones. Una exploracion adecuada y dirigida ante un paciente que acude a urgencias con un sindrome vestibular agudo resulta de vital importancia para establecer el diagnostico diferencial entre la patologia periferica y la central, ya que algunos accidentes cerebrovasculares se pueden presentar bajo la apariencia de un vertigo agudo. Aplicar un protocolo como HINTS permite sospechar la patologia central con una gran sensibilidad y especificidad.

  1. Legacy limits and hints of New Physics at the Tevatron

    SciTech Connect

    Duperrin, Arnaud; /Marseille, CPPM

    2011-12-01

    This paper reviews results of beyond-the-standard model searches at the Tevatron presented in a plenary talk at the Europhysics Conference on High Energy Physics (EPS-HEP) in Grenoble. Here I present a selection of results from the CDF and D0 experiments that were shown at the conference during the parallel sessions. Much more is available and can be found at the experiment's web pages. This proceeding essentially focuses on searches in the dilepton, diboson, and t{bar t} final states. Throughout the paper, hints of new physics observed at the Tevatron are also briefly discussed.

  2. Hints for a nonstandard Higgs boson from the LHC

    SciTech Connect

    Raidal, Martti; Strumia, Alessandro

    2011-10-01

    We reconsider Higgs boson invisible decays into Dark Matter in the light of recent Higgs searches at the LHC. Present hints in the Compact Muon Solenoid and ATLAS data favor a nonstandard Higgs boson with approximately 50% invisible branching ratio, and mass around 143 GeV. This situation can be realized within the simplest thermal scalar singlet Dark Matter model, predicting a Dark Matter mass around 50 GeV and direct detection cross section just below present bound. The present runs of the Xenon100 and LHC experiments can test this possibility.

  3. The Effects of Cognitive Styles on the Use of Hints in Academic English: A Learning Analytics Approach

    ERIC Educational Resources Information Center

    Chen, Sherry Y.; Yeh, Chia-Chi

    2017-01-01

    Various hints have been proposed to scaffold students. Such hints can be broadly divided into direct hints and indirect hints. On the other hand, individual differences existed among learners. In particular, cognitive styles greatly affect student learning. However, there is a lack of studies to investigate how cognitive styles affect students'…

  4. Transfer of metacognitive skills and hint seeking in monkeys.

    PubMed

    Kornell, Nate; Son, Lisa K; Terrace, Herbert S

    2007-01-01

    Metacognition is knowledge that can be expressed as confidence judgments about what one knows (monitoring) and by strategies for learning what one does not know (control). Although there is a substantial literature on cognitive processes in animals, little is known about their metacognitive abilities. Here we show that rhesus macaques, trained previously to make retrospective confidence judgments about their performance on perceptual tasks, transferred that ability immediately to a new perceptual task and to a working memory task. We also show that monkeys can learn to request "hints" when they are given problems that they would otherwise have to solve by trial and error. This study demonstrates, for the first time, that nonhuman primates share with humans the ability to monitor and transfer their metacognitive ability both within and between different cognitive tasks, and to seek new knowledge on a need-to-know basis.

  5. Hints of quantum gravity from the horizon fluid

    NASA Astrophysics Data System (ADS)

    Cropp, Bethan; Bhattacharya, Swastik; Shankaranarayanan, S.

    2017-01-01

    For many years, researchers have tried to glean hints about quantum gravity from black hole thermodynamics. However, black hole thermodynamics suffers from the problem of universality—at leading order, several approaches with different microscopic degrees of freedom lead to Bekenstein-Hawking entropy. We attempt to bypass this issue by using a minimal statistical mechanical model for the horizon fluid based on the Damour-Navier-Stokes (DNS) equation. For stationary asymptotically flat black hole spacetimes in general relativity, we show explicitly that, at equilibrium, the entropy of the horizon fluid is the Bekenstein-Hawking entropy. Further, we show that, for the bulk viscosity of the fluctuations of the horizon fluid to be identical to Damour, a confinement scale exists for these fluctuations, implying quantization of the horizon area. The implications and possible mechanisms from the fluid point of view are discussed.

  6. Understanding Attention to Adaptive Hints in Educational Games: An Eye-Tracking Study

    ERIC Educational Resources Information Center

    Conati, Cristina; Jaques, Natasha; Muir, Mary

    2013-01-01

    This paper presents a user study that investigates the factors affecting student attention to user-adaptive hints during interaction with an educational computer game. The study focuses on Prime Climb, an educational game designed to provide individualized support for learning number factorization skills in the form of textual hints based on a…

  7. Understanding Attention to Adaptive Hints in Educational Games: An Eye-Tracking Study

    ERIC Educational Resources Information Center

    Conati, Cristina; Jaques, Natasha; Muir, Mary

    2013-01-01

    This paper presents a user study that investigates the factors affecting student attention to user-adaptive hints during interaction with an educational computer game. The study focuses on Prime Climb, an educational game designed to provide individualized support for learning number factorization skills in the form of textual hints based on a…

  8. Court Briefs.

    ERIC Educational Resources Information Center

    Nankivell, R.; And Others

    1990-01-01

    Presents court briefs for three separate constitutional issues: the individual right to die as tested in the "Cruzan v. Missouri Department of Health" case; constitutional rights and drunk driving; and student religious clubs' right to meet at public schools in accordance with the Equal Access Act of 1984. Analyzes court opinions and…

  9. Briefing Executives

    DTIC Science & Technology

    2015-09-01

    in order to move forward. You have to report some bad news. Or maybe it is just an information brief to someone with a reputation for asking hard...misunderstanding, and we were able to move on. Getting up the nerve to push back wasn’t easy—Meyer had a reputation for gruffness and great technical

  10. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    Dr. Jim Green, NASA‘s Planetary Science Division Director and Head of Mars Program, gives opening remarks at a media briefing where panelist outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of the agency’s Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  11. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    A model of the Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft is seen on display during a media briefing where panelist outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of MAVEN, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  12. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    Lisa May, lead program executive, Mars Exploration Program, NASA Headquarters gives remarks during a media briefing where she and other panelist outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of the agency’s Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  13. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    Dwayne Brown, NASA public affairs officer, moderates a media briefing where panelist outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of the agency’s Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  14. Court Briefs.

    ERIC Educational Resources Information Center

    Nankivell, R.; And Others

    1990-01-01

    Presents court briefs for three separate constitutional issues: the individual right to die as tested in the "Cruzan v. Missouri Department of Health" case; constitutional rights and drunk driving; and student religious clubs' right to meet at public schools in accordance with the Equal Access Act of 1984. Analyzes court opinions and…

  15. Particle Swarm Optimization algorithms for geophysical inversion, practical hints

    NASA Astrophysics Data System (ADS)

    Garcia Gonzalo, E.; Fernandez Martinez, J.; Fernandez Alvarez, J.; Kuzma, H.; Menendez Perez, C.

    2008-12-01

    PSO is a stochastic optimization technique that has been successfully used in many different engineering fields. PSO algorithm can be physically interpreted as a stochastic damped mass-spring system (Fernandez Martinez and Garcia Gonzalo 2008). Based on this analogy we present a whole family of PSO algorithms and their respective first order and second order stability regions. Their performance is also checked using synthetic functions (Rosenbrock and Griewank) showing a degree of ill-posedness similar to that found in many geophysical inverse problems. Finally, we present the application of these algorithms to the analysis of a Vertical Electrical Sounding inverse problem associated to a seawater intrusion in a coastal aquifer in South Spain. We analyze the role of PSO parameters (inertia, local and global accelerations and discretization step), both in convergence curves and in the a posteriori sampling of the depth of an intrusion. Comparison is made with binary genetic algorithms and simulated annealing. As result of this analysis, practical hints are given to select the correct algorithm and to tune the corresponding PSO parameters. Fernandez Martinez, J.L., Garcia Gonzalo, E., 2008a. The generalized PSO: a new door to PSO evolution. Journal of Artificial Evolution and Applications. DOI:10.1155/2008/861275.

  16. 'Hints' in the horn: diagnostic clues in the stratum corneum.

    PubMed

    Cardoso, José Carlos; Veraitch, Ophelia; Gianotti, Raffaele; Ferrara, Gerardo; Tomasini, Carlo F; Singh, Manuraj; Zalaudek, Iris; Stefanato, Catherine M

    2017-03-01

    The stratum corneum or horny layer is the uppermost layer of the epidermis, and is mainly responsible for the skin's barrier function. In spite of its complexity at the ultrastructural and molecular level, the features accessible to visualization on conventional histology are relatively limited. Nevertheless, knowledge of subtle clues that one may observe in the stratum corneum can prove useful in a wide range of situations in dermatopathology. We herein review a selection of common and rare entities in which the horny layer may reveal significantly important hints for the diagnosis. These clues include parakeratosis and its different patterns (focal, confluent, alternating, associated with spongiosis, epidermal hyperplasia or lichenoid changes), subcorneal acantholysis, infectious organisms in the stratum corneum (including fungal, bacterial and parasitic), thickening or thinning of the stratum corneum and the presence of different kinds of pigment. Even when normal, the horny layer may prove to be useful when seen in association with severe epidermal damage, a combination of features testifying to the acute nature of the underlying pathological process. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Hints for Enhanced b -> sg From Charm and Kaon Counting

    SciTech Connect

    Rathsman, Johan

    2003-05-09

    Previously, motivation for enhanced b {yields} sg from new flavor physics has centered on discrepancies between theory and experiment. Here two experimental hints are considered: (1) updated measurements of the charm multiplicity and {Beta}({bar B} {yields} X{sub c{bar c}s}) at the {Upsilon}(4S) imply {Beta}(B {yields} X{sub no charm}) {approx} 12.4 {+-} 5.6%, (2) the {bar B} {yields} K{sup -}X and {bar B} {yields} K{sup +}/K{sup -}X branching fractions are in excess of conventional {bar B} {yields} X{sub c} {yields} KX yields by about 16.9 {+-} 5.6% and 18 {+-} 5.3%, respectively. JETSET 7.4 was used to estimate kaon yields from s{bar s} popping in {bar B} {yields} X{sub c{bar u}d} decays. JETSET 7.4 Monte Carlos for {Beta}({bar B} {yields} X{sub sg}) {approx} 15% imply that the additional kaon production would lead to 1{sigma} agreement with observed charged and neutral kaon yields. The K{sub s} momentum spectrum would be consistent with recent CLEO bounds in the end point region. Search strategies for enhanced b {yields} sg are discussed in light of large theoretical uncertainty in the standard model fast kaon background from b {yields} s penguin operators.

  18. Hint1 suppresses migration and invasion of hepatocellular carcinoma cells in vitro by modulating girdin activity.

    PubMed

    Wu, Xue-Song; Bao, Tian-Hao; Ke, Yang; Sun, De-Yun; Shi, Zhi-Tian; Tang, Hao-Ran; Wang, Lin

    2016-11-01

    Histidine triad nucleotide-binding protein 1 (Hint1) is a haploinsufficient tumor suppressor gene. Its role in cancer cell migration has not been previously speculated. In the current study, we examined the expression of Hint1 in metastatic and non-metastatic lymph nodes of hepatocellular carcinoma (HCC) patients and further elucidated the effect of Hint1 expression on girdin expression and phosphorylation of AKT and ERK1/2 and on the migration of HCC cells in vitro. Expression of Hint1 and girdin in primary HCC tissues and metastatic and non-metastatic lymph nodes was determined by RT-PCR assays. HepG2 cells were transfected with plasmid vectors overexpressing Hint1 or small interfering RNA (siRNA) targeting Hint1, girdin, Hint1 plus girdin, or the scrambled RNA. Migration and invasion of HCC cells were examined by wound and Transwell assays. Protein expression was detected by immunofluorescence and immunoblotting assays. RT-PCR assays revealed that the messenger RNA (mRNA) transcript levels of Hint1 were markedly lower than those of primary HCC tissues and non-metastatic lymph nodes (P < 0.01). By contrast, the mRNA transcript levels of girdin were significantly higher than non-metastatic lymph nodes (P < 0.05). Furthermore, siRNA knockdown of HINT1 resulted in a significant increase in the mRNA transcript levels of girdin in HepG2 cells (P < 0.05). Wound assays and Transwell assays showed that Hint1 knockdown by siRNA significantly enhanced the migration and invasion of HepG2 cells compared to HepG2 cells transfected with scrambled siRNA. Hint1 knockdown also led to significantly increased phosphorylation of girdin and AKT in HepG2 cells (P < 0.05), which, however, was effectively aborted by girdin knockdown by siRNA (P < 0.05). Hint1 is downregulated in metastatic lymph nodes and is implicated in migration and invasion of HCC cells in vitro by modulating girdin and AKT expression and phosphorylation. The Hint1-girdin-AKT signaling axis should be

  19. Basics of compounding: Tips and hints, part 4: lollipops/lozenges, gummy bears, patches, flavoring/coloring, sweeteners, and packaging.

    PubMed

    Allen, Loyd V

    2014-01-01

    Just a reminder--shortcuts, tips, hints, new techniques, etc. help make every compounder's job easier and enhance patient care. Keep a list of these tips and hints and add to them as new techniques are developed.

  20. 10 Helpful hints for dementia design at home 10 Helpful hints for dementia design at home June Andrews and Colm Cunningham Dementia Services Development Centre £7.50 54pp 9781857692549 1857692543 [Formula: see text].

    PubMed

    2012-02-24

    THERE ARE more than 40 pages of hints in this short booklet, covering lighting, sound, interior decor and the use of assistive technology among other areas. Each section has an illustration relevant to one of the hints. A short paragraph is included about each hint and there are many illustrations of the experiences of people living with dementia.

  1. [HINT1--a novel tumor suppressor protein of the HIT superfamily].

    PubMed

    Ozga, Magdalena

    2010-01-01

    The histidine triad nucleotide binding protein1 (Hint1) belongs to the first branch of the HIT superfamily. Hint1 catalyses the process of hydrolysis of the P-N bond in AMP-lysine, AMP-alanine, AMP-NH2. The physiological role of this enzyme is still unclear. There is accumulating evidence that HINT1 is a novel tumor suppressor protein, albeit the mechanism of action of HINT1 in respect to tumor suppression is not fully understood. Recent findings have shown that Hint1 inhibits the activity of the transcription factors AP1, MITF and USF2, as well as influences the transcription process of some genes of Wnt/beta-catenin pathway. Thereby, it seems that Hint1 exerts its major cellular function as gene transcription regulator, and thus, this function provides its potential role as a tumor suppressor protein. The clinical relevance of impairments in the Hint1 expression with the respect to specific human cancers is still a matter of extensive studies.

  2. Lack of Neuropathy-Related Phenotypes in Hint1 Knockout Mice

    PubMed Central

    Seburn, Kevin L.; Morelli, Kathryn H.; Jordanova, Albena; Burgess, Robert W.

    2014-01-01

    Mutations in HINT1, the gene encoding histidine triad nucleotide-binding protein 1 (HINT1), cause a recessively inherited peripheral neuropathy that involves primarily motor dysfunction and is usually associated with neuromyotonia, i.e. prolonged muscle contraction resulting from hyperexcitability of the peripheral nerve. Because these mutations are hypothesized to cause loss of function, we analyzed Hint1 knockout mice for their relevance as a disease model. Mice lacking Hint1 were normal in appearance and in behavioral tests or motor performance, although they moved slower and for a smaller fraction of time than wild-type (WT) mice in an open field arena. Muscles, neuromuscular junctions, and nodes of Ranvier are anatomically normal and did not show evidence of degeneration or regeneration. Axon numbers and myelination in peripheral nerves were normal at 4 and 13 months of age. Axons were slightly smaller than those in WT mice at 4 months of age, but this did not cause a decrease in conduction velocity, and no differences in axon diameters were detected at 13 months. Using electromyography, we were unable to detect neuromyotonia, even using supra-physiological stimuli and stressors such as reduced temperature or 3,4 diaminopyridine to block potassium channels. Therefore, we conclude that Hint1 knockout mice may be useful for studying the biochemical activities of HINT1, but these mice do not provide a disease model or a means for investigating the basis of HINT1-associated neuropathy and neuromyotonia. PMID:24918641

  3. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    Bruce Jakosky, MAVEN principal investigator, Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, is seen during a media briefing where he and other panelist outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of the agency’s Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  4. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    Bruce Jakosky, MAVEN principal investigator, Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, left, and David Mitchell, MAVEN project manager, NASA’s Goddard Space Flight Center, Greenbelt, Maryland are seen during a media briefing where they and other panelist outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of the agency’s Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  5. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    Lisa May, lead program executive, Mars Exploration Program, NASA Headquarters, and Bruce Jakosky, MAVEN principal investigator, Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, are seen during a media briefing where they and other panelist outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of the agency’s Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  6. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    Guy Beutelschies, Lockheed Martin MAVEN program manager, Lockheed Martin Space Systems Company, Littleton, Colorado is seen during a media briefing where he and other panelist outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of the agency’s Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  7. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    David Mitchell, MAVEN project manager, NASA’s Goddard Space Flight Center, Greenbelt, Maryland is seen during a media briefing where he and other panelist outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of the agency’s Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  8. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    David Mitchell, MAVEN project manager, NASA’s Goddard Space Flight Center, Greenbelt, Maryland, left, and Guy Beutelschies, Lockheed Martin MAVEN program manager, Lockheed Martin Space Systems Company, Littleton, Colorado are seen during a media briefing where they and other panelist outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of the agency’s Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  9. Hints of Period Change for OGLE-TR-113b

    NASA Astrophysics Data System (ADS)

    Adams, Elisabeth R.; Lopez-Morales, M.; Elliot, J. L.; Seager, S.; Osip, D. J.

    2010-10-01

    We present six new transits of the hot Jupiter OGLE-TR-113b observed with MagIC on the Magellan Telescopes between January 2007 and May 2009. We update the system parameters and revise the planetary radius, where the error is dominated by stellar radius uncertainties. The new transit midtimes reveal no transit timing variations from a constant ephemeris over two years, which places an upper limit of 1-2 Earth masses on any perturber in a 1:2 or 2:1 mean-motion resonance with OGLE-TR-113b. Combining the new transit epochs with five epochs published between 2002 and 2006, we find hints that the orbital period of the planet may not be constant, with the best fit indicating the period is decreasing by 60±15 milliseconds per year. If real, this change in period could result from either a long-period (more than 8 years) timing variation due to an external perturber, or more intriguingly from the orbital decay of the planet. The detection of a changing period is still tentative and must be checked with additional observations. If a period decay is confirmed, OGLE-TR-113b will be the first planet observed to be falling onto its star. This would enable direct tests of tidal stability and dynamical models of close-in planets and place observational constraints on the value of stellar tidal energy dissipation factors. This work was supported in part by NASA Origins grant NNX07AN63G and Hubble Fellowship grant HF-01210.01-A/HF-51233.01 awarded by the STScI, which is operated by the AURA, Inc. for NASA, under contract NAS5-26555.

  10. Algebra and Trigonometry Review Workbook. Exercises with Hints and Complete Solutions in Algebra and Trigonometry.

    ERIC Educational Resources Information Center

    Goodman-Petrushka, Sharon

    This workbook is designed to be used as a review at the end of a college level course in algebra and trigonometry. Four review sheets containing 117 problems provide hints and detailed solutions for each problem. (YP)

  11. Lithospheric Decoupling and Rotations: Hints from Ethiopian Rift

    NASA Astrophysics Data System (ADS)

    Muluneh, A. A.; Cuffaro, M.; Doglioni, C.; Kidane, T.

    2014-12-01

    Plates move relative to the mantle because some torques are acting on them. The shear in the low-velocity zone (LVZ) at the base of the lithosphere is the expression of these torques. The decoupling is allowed by the low viscosity in the LVZ, which is likely few orders of magnitudes lower than previously estimated. The viscosity value in the LVZ controls the degree of coupling/decoupling between the lithosphere and the underlying mantle. Lateral variations in viscosity within the LVZ may explain the velocity gradient among tectonic plates as the one determining the Ethiopian Rift (ER) separating Africa from Somalia. While it remains not fully understood the mechanisms of the torques acting on the lithosphere (thermally driven mantle convection or the combination of mantle convection with astronomical forces such as the Earth's rotation and tidal drag), the stresses are transmitted across the different mechanical layers (e.g., the brittle upper crust, down to the viscous-plastic ductile lower crust and upper mantle). Differential basal shear traction at the base of the lithosphere beneath the two sides of the East African Rift System (EARS) is assumed to drive and sustain rifting. In our analysis, the differential torques acting on the lithospheric/crustal blocks drive kinematics and block rotations. Since, ER involves the whole lithosphere, we do not expect large amount of rotation. Rotation can be the result of the whole plate motion on the sphere moving along the tectonic equator, or the second order sub-rotation of a single plate. Further rotation may occur along oblique plate boundaries (e.g., left lateral transtensional setting at the ER). Small amount of vertical axis rotation of blocks in northern ER could be related to the presence of local, shallower decollement layers. Shallow brittle-ductile transition (BDT) zone and differential tilting of crustal blocks in the northern ER could hint a possibility of detachment surface between the flow in the lower

  12. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    Panelist, from left, Lisa May, lead program executive, Mars Exploration Program, NASA Headquarters, Washington, Bruce Jakosky, MAVEN principal investigator, Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, David Mitchell, MAVEN project manager, NASA’s Goddard Space Flight Center, Greenbelt, Maryland, and Guy Beutelschies, Lockheed Martin MAVEN program manager, Lockheed Martin Space Systems Company, Littleton, Colorado, all shake hands at the end of a media briefing where they outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of the agency’s Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  13. MAVEN Briefing

    NASA Image and Video Library

    2014-09-17

    Dwayne Brown, NASA public affairs officer, left, moderates a media briefing where panelist, seated from left, Lisa May, lead program executive, Mars Exploration Program, NASA Headquarters, Washington, Bruce Jakosky, MAVEN principal investigator, Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, David Mitchell, MAVEN project manager, NASA’s Goddard Space Flight Center, Greenbelt, Maryland, and Guy Beutelschies, Lockheed Martin MAVEN program manager, Lockheed Martin Space Systems Company, Littleton, Colorado, outlined activities around the Sunday, Sept. 21 orbital insertion at Mars of the agency’s Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, Wednesday, Sept. 17, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Bill Ingalls)

  14. Mars Briefing

    NASA Image and Video Library

    2011-08-04

    Colin Dundas, a research geologist with the U.S. Geological Survey, speaks during a briefing, Thursday, Aug. 4, 2011, at NASA Headquarters in Washington. Observations from NASA's Mars Reconnaissance Orbiter (MRO) have revealed possible flowing water during the warmest months on Mars. Dark, finger-like features appear and extend down some Martian slopes during late spring through summer, fade in winter, and return during the next spring. Repeated observations have tracked the seasonal changes in these recurring features on several steep slopes in the middle latitudes of Mars' southern hemisphere. Photo Credit: (NASA/Paul E. Alers)

  15. Mars Briefing

    NASA Image and Video Library

    2011-08-04

    Philip Christensen, a geophysicist at Arizona State University, speaks during a briefing, Thursday, Aug. 4, 2011, at NASA Headquarters in Washington. Observations from NASA's Mars Reconnaissance Orbiter (MRO) have revealed possible flowing water during the warmest months on Mars. Dark, finger-like features appear and extend down some Martian slopes during late spring through summer, fade in winter, and return during the next spring. Repeated observations have tracked the seasonal changes in these recurring features on several steep slopes in the middle latitudes of Mars' southern hemisphere. Photo Credit: (NASA/Paul E. Alers)

  16. Research Brief.

    PubMed

    Schoenfelder, Erin; McCabe, Connor; Fife, Aurora; Herzig, Lisa; Ahrens, Kym

    2017-01-01

    Adolescents with ADHD are at risk of functional problems that may be mitigated by consistent ADHD treatment. This study pilots a brief intervention for adolescents with ADHD and their parents to increase treatment knowledge and family motivation to seek treatment. The 3-hr curriculum was developed by a multidisciplinary team and included psychoeducation, goal setting, and motivational interviewing. Fifteen adolescents and 20 caregivers participated in the workshop, completed pre- and post-test assessments, and reported on acceptability. Acceptability and satisfaction with the intervention were high. Perceived knowledge of ADHD increased post intervention; stigma was unchanged. Parents reported more acceptability of stimulant medications and less willingness to use special diets or cognitive games. Family feedback informed modifications to the curriculum. The Teen ADHD Workshop is a feasible and acceptable intervention to increase knowledge of ADHD and evidence-based treatments. Further research will evaluate effects on treatment participation.

  17. Kinetic Mechanism of Human Histidine Triad Nucleotide Binding Protein 1 (Hint1)

    PubMed Central

    Zhou, Xin; Chou, Tsui-Fen; Aubol, Brandon E; Park, Chin Ju; Wolfenden, Richard; Adams, Joseph; Wagner, Carston R.

    2013-01-01

    Human histidine triad nucleotide binding protein 1 (hHint1) is a member of a ubiquitous and ancient branch of the histidine triad (HIT) protein superfamily. hHint1 is a homodimeric protein that catalyzes the hydrolysis of model substrates, phosphoramidate (TpAd) and acyl adenylate (AIPA), with a high efficiency. Recently, catalytically inactive hHint1 has been identified as the cause of inherited peripheral neuropathy (1). We have carried out the first detailed kinetic mechanistic studies of hHint1 and have found that the reaction mechanism is consistent with a double displacement mechanism, in which the active site nucleophile His112 is first adenylylated by the substrate, followed by hydrolysis of the AMP-enzyme intermediate. A transient burst phase followed by a linear phase from the stopped-flow fluorescence assay indicated that enzyme adenylylation was faster than the subsequent intermediate hydrolysis and product release. Solvent viscosity experiments suggested that both chemical transformation and diffusion-sensitive events (product release or protein conformational change) limit the overall turnover. The catalytic trapping experiments and data simulation indicated that the true koff rate of the final product AMP is unlikely to control the overall kcat. Therefore, a protein conformational change associated with product release is likely rate limiting. In addition, the rate of Hint1 adenylylation was found to be dependent on two residues with pKas of 6.5 and 8, with the former pKa agreeing well with the NMR titration results for the pKa of the active site nucleophile His112. When compared to the uncatalyzed rates, hHint1 was shown to enhance acyl-AMP and AMP phosphoramidate hydrolysis by 106 to 108- fold. Taken together, our analysis indicates that hHint1 catalyzes the hydrolysis of phosphoramidate and acyl adenylate with high efficiency, through a mechanism that relies on rapid adenylylation of the active residue, His-112, while being partially rate limited

  18. A Nonresponse Bias Analysis of the Health Information National Trends Survey (HINTS).

    PubMed

    Maitland, Aaron; Lin, Amy; Cantor, David; Jones, Mike; Moser, Richard P; Hesse, Bradford W; Davis, Terisa; Blake, Kelly D

    2017-07-01

    We conducted a nonresponse bias analysis of the Health Information National Trends Survey (HINTS) 4, Cycles 1 and 3, collected in 2011 and 2013, respectively, using three analysis methods: comparison of response rates for subgroups, comparison of estimates with weighting adjustments and external benchmarks, and level-of-effort analysis. Areas with higher concentrations of low socioeconomic status, higher concentrations of young households, and higher concentrations of minority and Hispanic populations had lower response rates. Estimates of health information seeking behavior were higher in HINTS compared to the National Health Interview Survey (NHIS). The HINTS estimate of doctors always explaining things in a way that the patient understands was not significantly different from the same estimate from the Medical Expenditure Panel Survey (MEPS); however, the HINTS estimate of health professionals always spending enough time with the patient was significantly lower than the same estimate from MEPS. A level-of-effort analysis found that those who respond later in the survey field period were less likely to have looked for information about health in the past 12 months, but found only small differences between early and late respondents for the majority of estimates examined. There is some evidence that estimates from HINTS could be biased toward finding higher levels of health information seeking.

  19. Hints at diapirism in Arabia Terra craters, Mars

    NASA Astrophysics Data System (ADS)

    Pozzobon, Riccardo; Pio Rossi, Angelo; Massironi, Matteo; Mazzarini, Francesco; Pondrelli, Monica; Marinangeli, Lucia; Unnithan, Vikram

    2014-05-01

    during bulge sequences deposition. One or - more likely - multiple layers of sulfates below the shallower levels of Arabia Terra surface need, in our opinion, to be hypothesized in order to explain all these contrasting observations. Indeed impact cratering on such an evaporate bearing layered target might have provided the ideal conditions of faulting, interconnectivity of evaporatic beds and lithostatic load release to allow diapirs ascent, In turn diapirism could have been responsible for central bulging as testified by outward dipping strata on stratified bulges, broad un-stratified bulges and folding (see Jackson and Vendeville, 1994 for typical salt tectonics). The depth of the fluid source calculated with a fractal method (Pozzobon et al., 2013) using the position of the small widespread mounds within Firsoff and Crommelin craters can give a hint of the average depth of the evaportic horizons (~4 km). As further developments we plan to test and quantify our model to take into account geological evidences, possible kinematics, rheology and stratigraphic constrains. References: Andrews-Hanna, J.C., and Lewis, K.W., 2011, Early Mars hydrology: 2. Hydrological evolution in the Noachian and Hesperian epochs: Journal of Geophysical Research, v. 116, p. E02007, doi: 10.1029/2010JE003709. Franchi, F., Rossi, A. P., Pondrelli, M., Cavalazzi, B. (2014) Geometry, stratigraphy and evidences for fluid expulsion within Crommelin crater deposits, Arabia Terra, Mars. Planet Space Sci., in press. DOI: 10.1016/j.pss.2013.12.013, Jackson M.P.A. & Vendeville B.C. (1994) - Regional extension as a geologic trigger for diapirism, GSA Bulletin, 106: 57-73, Pondrelli, M., Rossi, A. P., Ori, G.G., van Gasselt, S., Praeg, D., and Ceramicola, S., 2011, Mud volcanoes in the geologic record of Mars: The case of Firsoff crater: Earth and Planetary Science Letters, v. 304, p. 511-519, doi: 10.1016/j.epsl.2011.02.027., Pozzobon R. et al. (2013), AGU Fall Meeting, Abstract #1797270.

  20. Semantic Elaboration through Integration: Hints Both Facilitate and Inform the Process

    ERIC Educational Resources Information Center

    Bauer, Patricia J.; Varga, Nicole L.; King, Jessica E.; Nolen, Ayla M.; White, Elizabeth A.

    2015-01-01

    Semantic knowledge can be extended in a variety of ways, including self-generation of new facts through integration of separate yet related episodes. We sought to promote integration and self-generation by providing "hints" to help 6-year-olds (Experiment 1) and 4-year-olds (Experiment 2) see the relevance of separate episodes to one…

  1. Adult Participation in Children's Word Searches: On the Use of Prompting, Hinting, and Supplying a Model

    ERIC Educational Resources Information Center

    Radford, Julie

    2010-01-01

    Although word searching in children is very common, very little is known about how adults support children in the turns following the child's search behaviours, an important topic because of the social, educational, and clinical implications. This study characterizes, in detail, teachers' use of prompting, hinting, and supplying a model. From a…

  2. Hint of CPT Violation in Short-Baseline Electron Neutrino Disappearance

    NASA Astrophysics Data System (ADS)

    Giunti, Carlo; Laveder, Marco

    2011-12-01

    We analyzed the electron neutrino data of the Gallium radioactive source experiments and the electron antineutrino data of the reactor Bugey and Chooz experiments in terms of neutrino oscillations. We found a hint of a CPT-violating asymmetry of the effective neutrino and antineutrino mixing angles.

  3. Interaction Networks: Generating High Level Hints Based on Network Community Clustering

    ERIC Educational Resources Information Center

    Eagle, Michael; Johnson, Matthew; Barnes, Tiffany

    2012-01-01

    We introduce a novel data structure, the Interaction Network, for representing interaction-data from open problem solving environment tutors. We show how using network community detecting techniques are used to identify sub-goals in problems in a logic tutor. We then use those community structures to generate high level hints between sub-goals.…

  4. Data-Driven Hint Generation in Vast Solution Spaces: A Self-Improving Python Programming Tutor

    ERIC Educational Resources Information Center

    Rivers, Kelly; Koedinger, Kenneth R.

    2017-01-01

    To provide personalized help to students who are working on code-writing problems, we introduce a data-driven tutoring system, ITAP (Intelligent Teaching Assistant for Programming). ITAP uses state abstraction, path construction, and state reification to automatically generate personalized hints for students, even when given states that have not…

  5. Evident or doubtful? How lexical hints in written information influence laypersons' understanding of influenza.

    PubMed

    Mayweg-Paus, Elisabeth; Jucks, Regina

    2015-01-01

    There are clear differences in the way written information on health issues presents research findings. In some cases, the source of a piece of information (e.g. "expert professor") is highlighted to emphasize its credibility and relevance. In other cases, the impact of a certain argument is stressed by avoiding hints on tentativeness such as "mostly" or "up to now." This article examines whether and how far such differences influence laypersons' comprehension of the contents provided. In an experimental setting, 157 laypersons were asked to read an online article on a new approach to preventing influenza. The texts manipulated whether there were (a) hints on the source of information and (b) lexical hints on the tentativeness of the information (hedges). After reading the text, participants were asked to write an essay reporting their opinion on the topic. Their argumentation on vaccination was assessed with content analysis and their attitudes toward vaccination were surveyed with a questionnaire. Results indicated that when lexical hints were given, tentativeness led participants to focus more on the actual information in the text. Additionally, decisions more strongly favored the direction implied in the text when the source of the medical information was not reported. Consequences for the way health information should be presented to laypersons are discussed.

  6. Data-Driven Hint Generation in Vast Solution Spaces: A Self-Improving Python Programming Tutor

    ERIC Educational Resources Information Center

    Rivers, Kelly; Koedinger, Kenneth R.

    2017-01-01

    To provide personalized help to students who are working on code-writing problems, we introduce a data-driven tutoring system, ITAP (Intelligent Teaching Assistant for Programming). ITAP uses state abstraction, path construction, and state reification to automatically generate personalized hints for students, even when given states that have not…

  7. Semantic Elaboration through Integration: Hints Both Facilitate and Inform the Process

    ERIC Educational Resources Information Center

    Bauer, Patricia J.; Varga, Nicole L.; King, Jessica E.; Nolen, Ayla M.; White, Elizabeth A.

    2015-01-01

    Semantic knowledge can be extended in a variety of ways, including self-generation of new facts through integration of separate yet related episodes. We sought to promote integration and self-generation by providing "hints" to help 6-year-olds (Experiment 1) and 4-year-olds (Experiment 2) see the relevance of separate episodes to one…

  8. Helpful Hints for School Emergency Management: Steps for Developing a School Emergency Management Plan

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    "Helpful Hints" offers a quick overview of school emergency preparedness topics that are frequently the subject of inquiries. The U.S. Department of Education's Office of Safe and Drug-Free Schools strongly encourages schools and school districts to develop emergency management plans within the context of the four phases of emergency management:…

  9. Enhancement of Student Learning through the Use of a Hinting Computer E-Learning System and Comparison with Human Teachers

    ERIC Educational Resources Information Center

    Munoz-Merino, P. J.; Kloos, C. D.; Munoz-Organero, M.

    2011-01-01

    This paper reports the results of an experiment in a Computer Architecture Laboratory course classroom session, in which students were divided into two groups for interaction both with a hinting e-learning system and with human teachers generating hints. The results show that there were high learning gains for both groups, demonstrating the…

  10. Stoic Behavior Hypothesis in Hint Seeking and Development of Reversi Learning Environment as Work Bench for Investigation

    ERIC Educational Resources Information Center

    Miwa, Kazuhisa; Kojima, Kazuaki; Terai, Hitoshi

    2014-01-01

    Tutoring systems provide students with various types of on-demand and context-sensitive hints. Students are required to consciously adapt their help-seeking behavior, proactively seek help in some situations, and solve problems independently without supports in other situations. We define the latter behavior as stoic behavior in hint seeking. In…

  11. Rationale, Procedures, and Response Rates for the 2015 Administration of NCI's Health Information National Trends Survey: HINTS-FDA 2015.

    PubMed

    Blake, Kelly D; Portnoy, David B; Kaufman, Annette R; Lin, Chung-Tung Jordan; Lo, Serena C; Backlund, Eric; Cantor, David; Hicks, Lloyd; Lin, Amy; Caporaso, Andrew; Davis, Terisa; Moser, Richard P; Hesse, Bradford W

    2016-12-01

    The National Cancer Institute (NCI) developed the Health Information National Trends Survey (HINTS) to monitor population trends in cancer communication practices, information preferences, health risk behaviors, attitudes, and cancer knowledge. The U.S. Food and Drug Administration (FDA) recognized HINTS as a unique data resource for informing its health communication endeavors and partnered with NCI to field HINTS-FDA 2015. HINTS-FDA 2015 was a self-administered paper instrument sent by mail May 29 to September 8, 2015, using a random probability-based sample of U.S. postal addresses stratified by county-level smoking rates, with an oversampling of high and medium-high smoking strata to increase the yield of current smokers responding to the survey. The response rate for HINTS-FDA 2015 was 33% (N = 3,738). The yield of current smokers (n = 495) was lower than expected, but the sampling strategy achieved the goal of obtaining more former smokers (n = 1,132). Public-use HINTS-FDA 2015 data and supporting documentation have been available for download and secondary data analyses since June 2016 at http://hints.cancer.gov . NCI and FDA encourage the use of HINTS-FDA for health communication research and practice related to tobacco-related communications, public knowledge, and behaviors as well as beliefs and actions related to medical products and dietary supplements.

  12. The Problem with Briefs, in Brief

    ERIC Educational Resources Information Center

    Conaway, Carrie L.

    2013-01-01

    Policy briefs written by academics--the kind typically published in "Education Finance and Policy"--should be a crucial source of information for policy makers. Yet too frequently these briefs fail to garner the consideration they deserve. Their authors are too focused on the potential objections of their fellow academics, who are…

  13. Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level.

    PubMed

    Barbier, Elisabeth; Wang, Jia Bei

    2009-11-13

    Protein kinase C interacting protein (PKCI/HINT1) is a small protein belonging to the histidine triad (HIT) family proteins. Its brain immunoreactivity is located in neurons and neuronal processes. PKCI/HINT1 gene knockout (KO) mice display hyper-locomotion in response to D-amphetamine which is considered a positive symptom of schizophrenia in animal models. Postmortem studies identified PKCI/HINT1 as a candidate molecule for schizophrenia and bipolar disorder. We investigated the hypothesis that the PKCI/HINT1 gene may play an important role in regulating mood function in the CNS. We submitted PKCI/HINT1 KO mice and their wild type (WT) littermates to behavioral tests used to study anti-depressant, anxiety like behaviors, and goal-oriented behavior. Additionally, as many mood disorders coincide with modifications of hypothalamic-pituitary-adrenal (HPA) axis function, we assessed the HPA activity through measurement of plasma corticosterone levels. Compared to the WT controls, KO mice exhibited less immobility in the forced swim (FST) and the tail suspension (TST) tests. Activity in the TST tended to be attenuated by acute treatment with valproate at 300 mg/kg in KO mice. The PKCI/HINT1 KO mice presented less thigmotaxis in the Morris water maze and spent progressively more time in the lit compartment in the light/dark test. In a place navigation task, KO mice exhibited enhanced acquisition and retention. Furthermore, the afternoon basal plasma corticosterone level in PKCI/HINT1 KO mice was significantly higher than in the WT. PKCI/HINT1 KO mice displayed a phenotype of behavioral and endocrine features which indicate changes of mood function, including anxiolytic-like and anti-depressant like behaviors, in conjunction with an elevated corticosterone level in plasma. These results suggest that the PKCI/HINT 1 gene could be important for the mood regulation function in the CNS.

  14. Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level

    PubMed Central

    2009-01-01

    Background Protein kinase C interacting protein (PKCI/HINT1) is a small protein belonging to the histidine triad (HIT) family proteins. Its brain immunoreactivity is located in neurons and neuronal processes. PKCI/HINT1 gene knockout (KO) mice display hyper-locomotion in response to D-amphetamine which is considered a positive symptom of schizophrenia in animal models. Postmortem studies identified PKCI/HINT1 as a candidate molecule for schizophrenia and bipolar disorder. We investigated the hypothesis that the PKCI/HINT1 gene may play an important role in regulating mood function in the CNS. We submitted PKCI/HINT1 KO mice and their wild type (WT) littermates to behavioral tests used to study anti-depressant, anxiety like behaviors, and goal-oriented behavior. Additionally, as many mood disorders coincide with modifications of hypothalamic-pituitary-adrenal (HPA) axis function, we assessed the HPA activity through measurement of plasma corticosterone levels. Results Compared to the WT controls, KO mice exhibited less immobility in the forced swim (FST) and the tail suspension (TST) tests. Activity in the TST tended to be attenuated by acute treatment with valproate at 300 mg/kg in KO mice. The PKCI/HINT1 KO mice presented less thigmotaxis in the Morris water maze and spent progressively more time in the lit compartment in the light/dark test. In a place navigation task, KO mice exhibited enhanced acquisition and retention. Furthermore, the afternoon basal plasma corticosterone level in PKCI/HINT1 KO mice was significantly higher than in the WT. Conclusion PKCI/HINT1 KO mice displayed a phenotype of behavioral and endocrine features which indicate changes of mood function, including anxiolytic-like and anti-depressant like behaviors, in conjunction with an elevated corticosterone level in plasma. These results suggest that the PKCI/HINT 1 gene could be important for the mood regulation function in the CNS. PMID:19912621

  15. The Diagnostic Accuracy of Truncal Ataxia and HINTS as Cardinal Signs for Acute Vestibular Syndrome

    PubMed Central

    Carmona, Sergio; Martínez, Carlos; Zalazar, Guillermo; Moro, Marcela; Batuecas-Caletrio, Angel; Luis, Leonel; Gordon, Carlos

    2016-01-01

    The head impulse, nystagmus type, test of skew (HINTS) protocol set a new paradigm to differentiate peripheral vestibular disease from stroke in patients with acute vestibular syndrome (AVS). The relationship between degree of truncal ataxia and stroke has not been systematically studied in patients with AVS. We studied a group of 114 patients who were admitted to a General Hospital due to AVS, 72 of them with vestibular neuritis (based on positive head impulse, abnormal caloric tests, and negative MRI) and the rest with stroke: 32 in the posterior inferior cerebellar artery (PICA) territory (positive HINTS findings, positive MRI) and 10 in the anterior inferior cerebellar artery (AICA) territory (variable findings and grade 3 ataxia, positive MRI). Truncal ataxia was measured by independent observers as grade 1, mild to moderate imbalance with walking independently; grade 2, severe imbalance with standing, but cannot walk without support; and grade 3, falling at upright posture. When we applied the HINTS protocol to our sample, we obtained 100% sensitivity and 94.4% specificity, similar to previously published findings. Only those patients with stroke presented with grade 3 ataxia. Of those with grade 2 ataxia (n = 38), 11 had cerebellar stroke and 28 had vestibular neuritis, not related to the patient’s age. Grade 2–3 ataxia was 92.9% sensitive and 61.1% specific to detect AICA/PICA stroke in patients with AVS, with 100% sensitivity to detect AICA stroke. In turn, two signs (nystagmus of central origin and grade 2–3 Ataxia) had 100% sensitivity and 61.1% specificity. Ataxia is less sensitive than HINTS but much easier to evaluate. PMID:27551274

  16. The Diagnostic Accuracy of Truncal Ataxia and HINTS as Cardinal Signs for Acute Vestibular Syndrome.

    PubMed

    Carmona, Sergio; Martínez, Carlos; Zalazar, Guillermo; Moro, Marcela; Batuecas-Caletrio, Angel; Luis, Leonel; Gordon, Carlos

    2016-01-01

    The head impulse, nystagmus type, test of skew (HINTS) protocol set a new paradigm to differentiate peripheral vestibular disease from stroke in patients with acute vestibular syndrome (AVS). The relationship between degree of truncal ataxia and stroke has not been systematically studied in patients with AVS. We studied a group of 114 patients who were admitted to a General Hospital due to AVS, 72 of them with vestibular neuritis (based on positive head impulse, abnormal caloric tests, and negative MRI) and the rest with stroke: 32 in the posterior inferior cerebellar artery (PICA) territory (positive HINTS findings, positive MRI) and 10 in the anterior inferior cerebellar artery (AICA) territory (variable findings and grade 3 ataxia, positive MRI). Truncal ataxia was measured by independent observers as grade 1, mild to moderate imbalance with walking independently; grade 2, severe imbalance with standing, but cannot walk without support; and grade 3, falling at upright posture. When we applied the HINTS protocol to our sample, we obtained 100% sensitivity and 94.4% specificity, similar to previously published findings. Only those patients with stroke presented with grade 3 ataxia. Of those with grade 2 ataxia (n = 38), 11 had cerebellar stroke and 28 had vestibular neuritis, not related to the patient's age. Grade 2-3 ataxia was 92.9% sensitive and 61.1% specific to detect AICA/PICA stroke in patients with AVS, with 100% sensitivity to detect AICA stroke. In turn, two signs (nystagmus of central origin and grade 2-3 Ataxia) had 100% sensitivity and 61.1% specificity. Ataxia is less sensitive than HINTS but much easier to evaluate.

  17. Comparison of Hearing in Noise Test (HINT) Scores Using Three Different Transducers

    DTIC Science & Technology

    2007-02-01

    earphones , and Group #3 was tested with the CEP. Presentation sequence of all speech materials was randomized using a Latin Squares design to reduce...between the THD-39P results and those obtained from the other two insert earphones in the quite condition that was likely due to a calibration issue...Conclusion: Insert-type earphones should be considered for administration of the HINT once a correction factor has been established. 15. SUBJECT TERMS

  18. Exome sequencing reveals HINT1 mutations as a cause of distal hereditary motor neuropathy

    PubMed Central

    Zhao, Hui; Race, Valérie; Matthijs, Gert; De Jonghe, Peter; Robberecht, Wim; Lambrechts, Diether; Van Damme, Philip

    2014-01-01

    Distal hereditary motor neuropathies (dHMNs) are a heterogenous group of genetic disorders with length-dependent degeneration of motor axons. Obtaining a genetic diagnosis in patients with dHMN remains challenging. We performed exome sequencing in a diagnostic setting in 12 patients with a clinical diagnosis of dHMN. Potential disease-causing variants in genes associated with dHMN and other forms of inherited neuropathies/motor neuron diseases were validated using Sequenom. The coverage in the genes studied was >95% with an average coverage of >50 times. In none of the patients a mutations was found in genes previously reported to be associated with dHMN. However, in 2/12 patients a recessive mutation in histidine triad nucleotide binding protein 1 (HINT1, recently discovered as a cause of axonal neuropathy with neuromyotonia) was identified. Our results demonstrate the diagnostic value of exome sequencing for patients with inherited neuropathies. The phenotypic spectrum of recessive mutations in HINT1 includes dHMN. HINT1 should be added to the list of genes to check for in dHMN. PMID:24105373

  19. Helpful Hints.

    ERIC Educational Resources Information Center

    Science and Children, 1986

    1986-01-01

    Provides directives for the assembly of a skin sensitivity tester that can be used to examine the skin's function of feeling. Procedures for this experiment are reviewed and a chart for recording the data is also included. (ML)

  20. Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.

    PubMed

    Dolot, Rafał; Kaczmarek, Renata; Sęda, Aleksandra; Krakowiak, Agnieszka; Baraniak, Janina; Nawrot, Barbara

    2016-06-01

    Histidine triad nucleotide-binding protein 1 (HINT1) represents the most ancient and widespread branch in the histidine triad proteins superfamily. HINT1 plays an important role in various biological processes, and it has been found in many species. Here, we report the first structure (at a 2.34Å resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide, containing bis-phosphorothioated glycerol mimicking a polyphosphate chain, obtained from a primitive monoclinic space group P21 crystal. In addition, the apo form of hHINT1 at the space group P21 refined to 1.92Å is reported for comparative studies.

  1. ISAF Overview Brief

    DTIC Science & Technology

    2011-01-01

    OEF BATTLE V. NON-BATTLE INJURY (1-Year) NATO / ISAF UNCLASSIFIED NATO / ISAF UNCLASSIFIED ISAF Overview Brief, MHS Conference 2011 PEDIATRIC...ISAF UNCLASSIFIED NATO / ISAF UNCLASSIFIED ISAF Overview Brief, MHS Conference 2011 *Includes both battle and non‐battle  injury N= 715 CAUSE OF... INJURY (October 2010) NATO / ISAF UNCLASSIFIED NATO / ISAF UNCLASSIFIED ISAF Overview Brief, MHS Conference 2011 Tactical Field Care Combat Casualty

  2. AMAS Robotics Seminar Brief

    DTIC Science & Technology

    2011-07-19

    Unclassified Unclassified 19 July 2011 AMAS ROBOTICS SEMINAR BRIEF Aaron Hart, Product Integrator, RS JPO DISTRIBUTION STATEMENT A. Approved for...19-07-2011 to 19-07-2011 4. TITLE AND SUBTITLE robotics seminar brief 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES AMAS ROBOTICS SEMINAR BRIEF 14

  3. The boy who would be queen: hints and closets on children's television.

    PubMed

    Dennis, Jeffery P

    2009-01-01

    Although American television programs targeted at children and adolescents posit universal heterosexuality and never openly allude to LGBT persons, a content analysis of 102 episodes of 25 contemporary children's programs revealed many examples of resistance to the heteronormative ideology: intimate same-sex friendships; inclusive statements or stage business; scenes that hint at the existence of same-sex desire; gender-transgressive or otherwise gay-stereotyped characters; and jokes and references that require a knowledge of gay culture. The impact of this resistance on viewers is analyzed through fan fiction and artwork, and potential explanations are examined.

  4. P80, the HinT interacting membrane protein, is a secreted antigen of Mycoplasma hominis

    PubMed Central

    Hopfe, Miriam; Hoffmann, Ricarda; Henrich, Birgit

    2004-01-01

    Background Mycoplasmas are cell wall-less bacteria which encode a minimal set of proteins. In Mycoplasma hominis, the genes encoding the surface-localized membrane complex P60/P80 are in an operon with a gene encoding a cytoplasmic, nucleotide-binding protein with a characteristic Histidine triad motif (HinT). HinT is found in both procaryotes and eukaryotes and known to hydrolyze adenosine nucleotides in eukaryotes. Immuno-precipitation and BIACore analysis revealed an interaction between HinT and the P80 domain of the membrane complex. As the membrane anchored P80 carries an N-terminal uncleaved signal peptide we have proposed that the N-terminus extends into the cytoplasm and interacts with the cytosolic HinT. Results Further characterization of P80 suggested that the 4.7 kDa signal peptide is protected from cleavage only in the membrane bound form. We found several proteins were released into the supernatant of a logarithmic phase mycoplasma culture, including P80, which was reduced in size by 10 kDa. Western blot analysis of recombinant P80 mutants expressed in E. coli and differing in the N-terminal region revealed that mutation of the +1 position of the mature protein (Asn to Pro) which is important for signal peptidase I recognition resulted in reduced P80 secretion. All other P80 variants were released into the supernatant, in general as a 74 kDa protein encompassing the helical part of P80. Incubation of M. hominis cells in phosphate buffered saline supplemented with divalent cations revealed that the release of mycoplasma proteins into the supernatant was inhibited by high concentrations of calciumions. Conclusions Our model for secretion of the P80 protein of M. hominis implies a two-step process. In general the P80 protein is transported across the membrane and remains complexed to P60, surface-exposed and membrane anchored via the uncleaved signal sequence. Loss of the 4.7 kDa signal peptide seems to be a pre-requisite for P80 secretion, which is

  5. Developing a Policy Brief.

    PubMed

    Keepnews, David M

    2016-05-01

    A policy brief is a document that provides a succinct explanation and analysis of a policy issue or problem, together with policy options and recommendations for addressing that issue or problem. This article provides an explanation of what a policy brief is, how it is used, and how it is developed. © The Author(s) 2016.

  6. Lobby Day Issue Briefs.

    ERIC Educational Resources Information Center

    National Council of La Raza, Washington, DC. Office of Research Advocacy and Legislation.

    This compilation of seven briefs is intended to help citizens lobby United States senators, representatives, and their staff members on issues of importance to the Hispanic American community. Each brief synopsizes an issue, reviews current proposals for addressing the issue, and suggests the appropriate action that the member of congress should…

  7. Florida: State Policy Brief

    ERIC Educational Resources Information Center

    Corbett, Julie

    2015-01-01

    This brief is one in a series highlighting state policies, regulations, practices, laws, or other tools intended to create the necessary conditions for school and/or district turnaround. Each brief includes an overview of the relevant turnaround tool, its development process, its impact, and lessons learned that could assist other education…

  8. Mississippi: State Policy Brief

    ERIC Educational Resources Information Center

    Corbett, Julie

    2014-01-01

    This brief is one in a series highlighting state policies, regulations, practices, laws, or other tools intended to create the necessary conditions for school and/or district turnaround. Each brief includes an overview of the relevant turnaround tool, its development process, its impact, and lessons learned that could assist other education…

  9. Brief Interventions for Adolescents

    PubMed Central

    Winters, Ken C

    2016-01-01

    Public health concerns regarding adolescent alcohol and other drug involvement emphasize the need for continuing research to develop and evaluate preventive interventions for use in a variety of settings. This focus includes research on brief interventions. This short commentary piece provides an overview of the brief intervention literature and highlights future directions PMID:27182561

  10. [Adaptation of the Hinting Task theory of the mind test to Spanish].

    PubMed

    Gil, David; Fernández-Modamio, Mar; Bengochea, Rosario; Arrieta, Marta

    2012-01-01

    Many studies have found that patients with schizophrenia have a deficit in theory of mind. Some authors associate this deficit with the presence of symptoms, while others maintain that it can also be observed in patients in the remission phase. There is no reference test to assess theory of mind in schizophrenia, although one of the most used is the Hinting Task. The aim of the present study consists of adapting and validating, in Spanish, the 10 histories that make up this test. The study was conducted on a sample of 39 control subjects and 40 patients with schizophrenia. The internal consistency and the between-observer reliability and test-retest were assessed in both sample groups. The performance of the patients and control subjects were also compared. Good reliability data was obtained in the inter-observer and test-retest in the two samples. On the other hand, the internal consistency was somewhat low for all of the 10 histories. For this reason, and starting from a previous study, a reduced version of 5 histories was prepared, which showed good internal consistency. The patients with schizophrenia obtained a significantly lower score than the control subjects in 8 out of the 10 histories. The reduced Spanish version of the Hinting Task demonstrated good psychometric properties. When compared to the control group, the patients with schizophrenia had a deficit in theory of mind. Copyright © 2011 SEP y SEPB. Published by Elsevier Espana. All rights reserved.

  11. Performance of bilingual speakers on the English and Spanish versions of the Hearing in Noise Test (HINT).

    PubMed

    Weiss, Deborah; Dempsey, James J

    2008-01-01

    This study compared the performance of bilingual participants on the English and Spanish versions of the Hearing in Noise Test (HINT). The participants were divided into an early bilingual (EB) group and a late bilingual (LB) group based on age of second-language acquisition. All participants acquired Spanish as their first language (L1) and English as a second language (L2). Care was taken to ensure that all participants demonstrated at least a "good competence level" for self-rated speaking, understanding, reading, and writing skills in both English and Spanish. Results revealed superior performance on the Spanish HINT versus the English HINT in both quiet and in noise for both groups of participants. Significant differences in performance were noted for the EB versus the LB participants. A number of possible explanations for superior performance in L1 are provided, and implications for educating students in their L2 are discussed.

  12. Depleted Uranium: Technical Brief

    EPA Pesticide Factsheets

    This technical brief provides accepted data and references to additional sources for radiological and chemical characteristics, health risks and references for both the monitoring and measurement, and applicable treatment techniques for depleted uranium.

  13. Public Participation Guide: Briefings

    EPA Pesticide Factsheets

    Briefings are generally short presentations provided directly to community groups at their existing meetings or locations – such as social and civic clubs – to provide an overview or update on a project.

  14. Energy: Conservation, Energy Briefs

    ERIC Educational Resources Information Center

    Nation's Schools and Colleges, 1975

    1975-01-01

    A comprehensive energy conservation program at College of the Holy Cross has saved nearly one-third of the fuel oil and one-fifth of the electricity used at the college; briefs on boilers, lights, design. (Author/MLF)

  15. Energy: Conservation, Energy Briefs

    ERIC Educational Resources Information Center

    Nation's Schools and Colleges, 1975

    1975-01-01

    A comprehensive energy conservation program at College of the Holy Cross has saved nearly one-third of the fuel oil and one-fifth of the electricity used at the college; briefs on boilers, lights, design. (Author/MLF)

  16. Community Services Brief.

    ERIC Educational Resources Information Center

    ERIC Clearinghouse for Junior Colleges, Los Angeles, CA.

    This Brief reviews a variety of materials about two-year college community services programs. Specific topics include: their philosophy and definition, organization and administration, descriptions of noteworthy programs, and models for new community service programs. (Author/CK)

  17. Orbiting Carbon Observatory Briefing

    NASA Image and Video Library

    2009-01-29

    Charles Miller talks during a media briefing to discuss the upcoming Orbiting Carbon Observatory mission, the first NASA spacecraft dedicated to studying carbon dioxide, Thursday, Jan. 29, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul E. Alers)

  18. Orbiting Carbon Observatory Briefing

    NASA Image and Video Library

    2009-01-29

    Panelists are seen during a media briefing to discuss the upcoming Orbiting Carbon Observatory mission, the first NASA spacecraft dedicated to studying carbon dioxide, Thursday, Jan. 29, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul E. Alers)

  19. Orbiting Carbon Observatory Briefing

    NASA Image and Video Library

    2009-01-29

    Ralph Basilio talks during a media briefing to discuss the upcoming Orbiting Carbon Observatory mission, the first NASA spacecraft dedicated to studying carbon dioxide, Thursday, Jan. 29, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul E. Alers)

  20. Orbiting Carbon Observatory Briefing

    NASA Image and Video Library

    2009-01-29

    Eric Ianson speaks during a media briefing to discuss the upcoming Orbiting Carbon Observatory mission, the first NASA spacecraft dedicated to studying carbon dioxide, Thursday, Jan. 29, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul E. Alers)

  1. STEREO Press Briefing

    NASA Image and Video Library

    2011-08-17

    Craig DeForest, a staff scientist at the Southwest Research Institute in Boulder, Colo., speaks during a press briefing, Thursday, Aug. 18, 2011, at NASA Headquarters in Washington. The briefing was held to discusses new details about the structure of solar storms and the impact they have on Earth. The new information comes from NASA's Solar Terrestrial Relations Observatory, or STEREO, spacecraft and other NASA probes. Photo Credit: (NASA/GSFC/Rebecca Roth)

  2. STEREO Press Briefing

    NASA Image and Video Library

    2011-08-17

    Madhulika Guhathakurta, seated left, STEREO program scientist, speaks during a press briefing, Thursday, Aug. 18, 2011, at NASA Headquarters in Washington as Craig DeForest, David Webb and Alysha Reinard, look on. The briefing was held to discusses new details about the structure of solar storms and the impact they have on Earth. The new information comes from NASA's Solar Terrestrial Relations Observatory, or STEREO, spacecraft and other NASA probes. Photo Credit: (NASA/GSFC/Rebecca Roth)

  3. STEREO Press Briefing

    NASA Image and Video Library

    2011-08-17

    Craig DeForest, second from left, speaks during a press briefing, Thursday, Aug. 18, 2011, at NASA Headquarters in Washington as Madhulika Guhathakurta, left, David Webb and Alysha Reinard look on. The briefing was held to discusses new details about the structure of solar storms and the impact they have on Earth. The new information comes from NASA's Solar Terrestrial Relations Observatory, or STEREO, spacecraft and other NASA probes. Photo Credit: (NASA/GSFC/Rebecca Roth)

  4. STEREO Press Briefing

    NASA Image and Video Library

    2011-08-17

    Madhulika Guhathakurta, seated left, STEREO program scientist, speaks during a press briefing, Thursday, Aug. 18, 2011, at NASA Headquarters in Washington as Craig DeForest, David Webb and Alysha Reinard, look on. The briefing was held to discusses new details about the structure of solar storms and the impact they have on Earth. The new information comes from NASA's Solar Terrestrial Relations Observatory, or STEREO, spacecraft and other NASA probes. Photo Credit: (NASA/GSFC/Rebecca Roth).

  5. STEREO Press Briefing

    NASA Image and Video Library

    2011-08-17

    David Webb, a research physicist from the Institute for Scientific Research at Boston College speaks during a press briefing, Thursday, Aug. 18, 2011, at NASA Headquarters in Washington. The briefing was held to discuss new details about the structure of solar storms and the impact they have on Earth. The new information comes from NASA's Solar Terrestrial Relations Observatory, or STEREO, spacecraft and other NASA probes. Photo Credit: (NASA/GSFC/Rebecca Roth)

  6. STEREO Press Briefing

    NASA Image and Video Library

    2011-08-17

    Madhulika Guhathakurta, seated left, STEREO program scientist, speaks during a press briefing, Thursday, Aug. 18, 2011, at NASA Headquarters in Washington. The briefing was held to discusses new details about the structure of solar storms and the impact they have on Earth. The new information comes from NASA's Solar Terrestrial Relations Observatory, or STEREO, spacecraft and other NASA probes. Photo Credit: (NASA/GSFC/Rebecca Roth)

  7. STEREO Press Briefing

    NASA Image and Video Library

    2011-08-17

    Alysha Reinard, as research scientist with National Oceanic and Atmospheric Administration and the University of Colorado Boulder, speaks during a press briefing, Thursday, Aug. 18, 2011, at NASA Headquarters in Washington. The briefing was held to discusses new details about the structure of solar storms and the impact they have on Earth. The new information comes from NASA's Solar Terrestrial Relations Observatory, or STEREO, spacecraft and other NASA probes. Photo Credit: (NASA/GSFC/Rebecca Roth)

  8. Prescribing Brief Psychotherapy

    PubMed Central

    Schuyler, Dean

    2000-01-01

    Brief psychotherapy has demonstrated its effectiveness in treating emotional disorders and helping with problems that typically present to primary care physicians. Because practitioners receive little instruction about this treatment option and often have erroneous preconceived ideas about it, psychotherapy remains underprescribed. Effective brief therapy enables the patient to problem-solve, facilitates the relationship with the provider, and ultimately clarifies the patient's situation. Referral of appropriate patients for psychotherapy will enhance the effectiveness of the doctor in primary care. PMID:15014662

  9. Hints of theta13>0 from global neutrino data analysis.

    PubMed

    Fogli, G L; Lisi, E; Marrone, A; Palazzo, A; Rotunno, A M

    2008-10-03

    Nailing down the unknown neutrino mixing angle theta{13} is one of the most important goals in current lepton physics. In this context, we perform a global analysis of neutrino oscillation data, focusing on theta{13}, and including recent results [ (unpublished)]. We discuss two converging hints of theta{13}>0, each at the level of approximately 1sigma: an older one coming from atmospheric neutrino data, and a newer one coming from the combination of solar and long-baseline reactor neutrino data. Their combination provides the global estimate sin{2}theta{13}=0.016+/-0.010(1sigma), implying a preference for theta{13}>0 with non-negligible statistical significance ( approximately 90% C.L.). We discuss possible refinements of the experimental data analyses, which might sharpen such intriguing indications.

  10. Updating and Maintaining School Emergency Management Plans. Helpful Hints for School Emergency Management. Volume 2, Issue 3, 2007

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    "Helpful Hints" offers a quick overview of school emergency preparedness topics that are frequently the subject of inquiries. Developing and implementing comprehensive, multi-hazard emergency management plans is an ongoing process that must be consistently reinforced and strengthened. Opportunities for reviewing, strengthening and updating…

  11. What Does the Public Know about Preventing Cancer? Results from the Health Information National Trends Survey (HINTS)

    ERIC Educational Resources Information Center

    Hawkins, Nikki A.; Berkowitz, Zahava; Peipins, Lucy A.

    2010-01-01

    This study provides information about the public's familiarity with cancer prevention strategies and examines the association between this familiarity and actual prevention behavior. Data from interviews with 5,589 adults included in the 2003 Health Information National Trends Survey (HINTS) were analyzed. Most respondents were able to cite one or…

  12. What Does the Public Know about Preventing Cancer? Results from the Health Information National Trends Survey (HINTS)

    ERIC Educational Resources Information Center

    Hawkins, Nikki A.; Berkowitz, Zahava; Peipins, Lucy A.

    2010-01-01

    This study provides information about the public's familiarity with cancer prevention strategies and examines the association between this familiarity and actual prevention behavior. Data from interviews with 5,589 adults included in the 2003 Health Information National Trends Survey (HINTS) were analyzed. Most respondents were able to cite one or…

  13. Rationale, Procedures, and Response Rates for the 2015 Administration of NCI’s Health Information National Trends Survey: HINTS-FDA 2015

    PubMed Central

    BLAKE, KELLY D.; PORTNOY, DAVID B.; KAUFMAN, ANNETTE R.; LIN, CHUNG-TUNG JORDAN; LO, SERENA C.; BACKLUND, ERIC; CANTOR, DAVID; HICKS, LLOYD; LIN, AMY; CAPORASO, ANDREW; DAVIS, TERISA; MOSER, RICHARD P.; HESSE, BRADFORD W.

    2016-01-01

    The National Cancer Institute (NCI) developed the Health Information National Trends Survey (HINTS) to monitor population trends in cancer communication practices, information preferences, health risk behaviors, attitudes, and cancer knowledge. The U.S. Food and Drug Administration (FDA) recognized HINTS as a unique data resource for informing its health communication endeavors and partnered with NCI to field HINTS-FDA 2015. HINTS-FDA 2015 was a self-administered paper instrument sent by mail May 29 to September 8, 2015, using a random probability-based sample of U.S. postal addresses stratified by county-level smoking rates, with an oversampling of high and medium-high smoking strata to increase the yield of current smokers responding to the survey. The response rate for HINTS-FDA 2015 was 33% (N = 3,738). The yield of current smokers (n = 495) was lower than expected, but the sampling strategy achieved the goal of obtaining more former smokers (n = 1,132). Public-use HINTS-FDA 2015 data and supporting documentation have been available for download and secondary data analyses since June 2016 at http://hints.cancer.gov. NCI and FDA encourage the use of HINTS-FDA for health communication research and practice related to tobacco-related communications, public knowledge, and behaviors as well as beliefs and actions related to medical products and dietary supplements. PMID:27892827

  14. NASA educational briefs

    NASA Technical Reports Server (NTRS)

    Vogt, G. L.

    1982-01-01

    In response to a large public demand for information, the Educational Services Branch of NASA has undertaken a series of publications designed for use by teachers, titled 'Educational Briefs for the Classroom', which has resulted in six to eight issues each year for the last three years. Typical of the topics to which the series is dedicated have been space suits, manned spaceflight mission summaries, solar cells, planetary encounter data, orbits, and rocketry. The planning committee for Educational Briefs is aided in its selection of topics by the many letters received by NASA. Following the Voyager Saturn flybys, NASA received more than 175,000 letters from both children and adults.

  15. Myofunctional therapy: brief intervention.

    PubMed

    Bacha, S M; Rìspoli, C F

    1999-11-01

    This study addresses speech-language therapy in orofacial myology utilizing a Brief Intervention (in Portuguese: IntervenAão Fonoaudiológica Breve) (IFB). IFB is applied to patient groups between the ages of 8 and 15 years with orthodontic/orthopedic appliances in 1997. Results are presented indicating the advantages of using IFB for breathing, feeding, oral-facial habits, buccal hygiene and corporal posture/physical activity. It concludes that Brief Intervention can be accomplished in 8 sessions, is economically advantageous for use in group therapy, and may be used before or in conjunction with Myofunctional Therapy/Myotherapy.

  16. Recent developments: Industry briefs

    SciTech Connect

    1990-04-01

    Recent nuclear industry briefs are presented. These briefs include: Soviet Union to build Iran nuclear plant; Dension announces cuts in Elliot Lake production; Soviet environmental study delays Rostov startup; Cogema closes two mines; Namibian sanctions lifted by USA and Canada; US Energy and Kennecott restructors joint venture; Australians reelect Hawke; China to buy Soviet nuclear plant; Olympic Dam`s first sale of concentrates to USA; Uranevz buys one-third of Cogema`s Rabbit Lake operations; East and West Germany forming joint nuclear law; and Nova Scotia extends uranium exploration plan.

  17. Kepler Media Briefing

    NASA Image and Video Library

    2009-02-19

    William Borucki, principal investigator for Kepler Science at Ames Research Center, Moffett Field, Calif.,, second from left, talks about the Kepler mission during a media briefing, Thursday, Feb. 19, 2008, at NASA Headquarters in Washington. Kepler, the first mission with the ability to find planets like earth, is scheduled to launch on March 5, 2009 from Cape Canaveral Air Force Station, Fla. aboard a Delta II rocket. Joining Borucki at the briefing were Jon Morse, director, Astrophysics Division, NASA Headquarters, Jim Fanson, Kepler project manager at the Jet Propulsion Laboratory and Debra Fischer, a professor of Astronomy at San Francisco State University. Photo Credit: (NASA/Paul. E. Alers)

  18. Kepler Media Briefing

    NASA Image and Video Library

    2009-02-19

    Jon Morse, Director, Astrophysics Division, at NASA Headquarters, left, talks about the Kepler mission during a media briefing, Thursday, Feb. 19, 2008, at NASA Headquarters in Washington. Morse was joined at the briefing by William Borucki, principal investigator for Kepler Science at Ames Research Center, second left, Jim Fanson, Kepler Project Manager at the Jet Propulsion Laboratory and Debra Fischer, professor of Astronomy at San Francisco State University, right. Kepler is scheduled to launch on March 5, 2009 from Cape Canaveral Air Force Station, Fla. aboard a Delta II rocket. Photo Credit: (NASA/Paul. E. Alers)

  19. Recent developments: Industry briefs

    SciTech Connect

    1990-12-01

    Recent nuclear industry briefs are presented. These briefs include: uranium mine closures; all Ontario new reactor plans halted; B & W and GA form MHTGR fuel joint venture; Namibia seeks uranium sales in Japan; Minatco purchases remainder of Wolly Project; CGE agrees to relinquish control of Framatome; Oregon voter keep Trojan Nuclear Plant open; Soviets invited to Foratom meeting; court overrules NRC in licensing and training issues; Glencar exploration injoint venture with Hungarian mine; Soviet Union and Argentina to cooperate in breeder program; and German loads revive Atucha-2.

  20. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: Implications in neurological disorders

    PubMed Central

    Rodríguez-Muñoz, María; Cortés-Montero, Elsa; Pozo-Rodrigálvarez, Andrea; Sánchez-Blázquez, Pilar; Garzón-Niño, Javier

    2015-01-01

    In the brain, the histidine triad nucleotide-binding protein 1 (HINT1) and sigma 1 receptors (σ1Rs) coordinate the activity of certain G-protein coupled receptors (GPCRs) with that of glutamate N-methyl-D-aspartate receptors (NMDARs). To determine the role of HINT1-σ1R in the plasticity of GPCR-NMDAR interactions, substances acting at MOR, cannabinoid CB1 receptor, NMDAR and σ1R were injected into mice, and their effects were evaluated through in vivo, ex vivo, and in vitro assays. It was observed that HINT1 protein binds to GPCRs and NMDAR NR1 subunits in a calcium-independent manner, whereas σ1R binding to these proteins increases in the presence of calcium. In this scenario, σ1R agonists keep HINT1 at the GPCR and stimulate GPCR-NMDAR interaction, whereas σ1R antagonists transfer HINT1 to NR1 subunits and disengage both receptors. This regulation is lost in σ1R−/− mice, where HINT1 proteins mostly associate with NMDARs, and GPCRs are physically and functionally disconnected from NMDARs. In HINT1−/− mice, ischemia produces low NMDAR-mediated brain damage, suggesting that several different GPCRs enhance glutamate excitotoxicity via HINT1-σ1R. Thus, several GPCRs associate with NMDARs by a dynamic process under the physiological control of HINT1 proteins and σ1Rs. The NMDAR-HINT1-σ1R complex deserves attention because it offers new therapeutic opportunities. PMID:26461475

  1. The 2009 Legislative Briefing

    ERIC Educational Resources Information Center

    Gaines, Gale F., Comp.

    2009-01-01

    "The 2009 Legislative Briefing" is a topical summary of actions during the 2009 legislative sessions that affect education in the 16 SREB states. Topics include: state budgets and the economy; tax and revenue; teacher and faculty pay raises; retirement systems; issues affecting teachers and education leaders; health and safety;…

  2. The 2009 Legislative Briefing

    ERIC Educational Resources Information Center

    Gaines, Gale F., Comp.

    2009-01-01

    "The 2009 Legislative Briefing" is a topical summary of actions during the 2009 legislative sessions that affect education in the 16 SREB states. Topics include: state budgets and the economy; tax and revenue; teacher and faculty pay raises; retirement systems; issues affecting teachers and education leaders; health and safety;…

  3. Issue Brief on Diversity

    ERIC Educational Resources Information Center

    Division on Developmental Disabilities, Council for Exceptional Children (NJ1), 2013

    2013-01-01

    During the past year, the Diversity Committee of the Division of Developmental Disabilities (DDD) Board worked with the Board and the Issues Committee Chair to develop an issue brief addressing diversity, its impact on the membership and the wider community that is served by the work of DDD, resulting in recommendations that will influence policy…

  4. Superintendent's Briefing Book, 2011

    ERIC Educational Resources Information Center

    Educational Research Service, 2010

    2010-01-01

    The "2011 Superintendent's Briefing Book" provides comprehensive yet concise overviews of the best thinking available on a wide range of top-priority PreK-12 education concerns. This resource will prove invaluable in making research-based decisions with confidence, and in identifying programs and practices that will improve student achievement.…

  5. Research in Brief.

    ERIC Educational Resources Information Center

    Journalism Quarterly, 1984

    1984-01-01

    Brief research reports discuss Latin America as seen on United States network television; television news coverage of federal regulatory agencies; community perceptions of media impressions; active television viewing and cultivation hypothesis; the impact of cable on traditional television news viewing; George Kibbe Turner; advertising; and…

  6. Research in Brief.

    ERIC Educational Resources Information Center

    Journalism Quarterly, 1982

    1982-01-01

    Offers brief descriptions of research concerning (1) media bias toward business, (2) foreign affairs coverage in elite and mass periodicals, (3) how emphasis on people affects coverage of crime, (4) antisocial and prosocial behavior on prime-time television, (5) network news coverage of Iran, and (6) magazines' reporting on insects. (FL)

  7. Informatics: A Brief Survey.

    ERIC Educational Resources Information Center

    He, Shaoyi

    2003-01-01

    Provides a brief survey of informatics, defined as the application of information technology to various fields, with respect to its historical background, disciplinary identity, fundamental aspects, applications, and challenges. Highlights include biological, clinical, dental, environmental, geomatics, health, legal, management, medical, museum,…

  8. Superintendent's Briefing Book, 2011

    ERIC Educational Resources Information Center

    Educational Research Service, 2010

    2010-01-01

    The "2011 Superintendent's Briefing Book" provides comprehensive yet concise overviews of the best thinking available on a wide range of top-priority PreK-12 education concerns. This resource will prove invaluable in making research-based decisions with confidence, and in identifying programs and practices that will improve student achievement.…

  9. Poverty. Research Brief

    ERIC Educational Resources Information Center

    Walker, Karen

    2007-01-01

    How many people reading this brief believes they could financially survive in a household of four people on $19,784 a year? Yet, this was the official poverty threshold as determined by the federal government for 2005. During this same year, 17% of children under 18 lived below the poverty line, of which 14% were white, 11% Asian, 28% Hispanic and…

  10. A School Briefing Primer.

    ERIC Educational Resources Information Center

    Rush, Richard D.

    2001-01-01

    Examines the use of, and procedures for, a school walkthrough with architectural candidates to help school officials in selecting a design firm that fits their particular circumstances. Included are typical questions architects ask and special situations that may signal the need for a school briefing. (GR)

  11. Annual research briefs, 1994

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Briefs of the 1994 annual progress reports of the Research Fellows and students of the Center for Turbulence Research are presented. Subjects covered include turbulence combustion, large eddy simulation, Reynolds-averaged turbulence modeling, turbulence control, postprocessing, sound generation, and turbulence physics.

  12. Academic Bankruptcy. Policy Brief.

    ERIC Educational Resources Information Center

    Anderson, Amy Berk; Lewis, Anne C.

    In an effort to improve student achievement in low-performing districts, 22 states have developed academic bankruptcy laws, allowing them to intervene in districts that consistently fail to satisfy state education performance standards. This policy brief presents an overview of these statutes. The text offers a comparative summary of state…

  13. Research in Brief.

    ERIC Educational Resources Information Center

    Journalism Quarterly, 1980

    1980-01-01

    Eight brief research reports concerning a newspaper's conversion to VDTs, media evaluation by police chiefs, defending and indemnifying reporters in tort actions, newsmagazine coverage of the Supreme Court, pricing of advertising in weekly newspapers, the importance of writing, "yeasaying" in readership surveys, and public service utilization by…

  14. Expedition 8 Launch Briefing

    NASA Image and Video Library

    2003-10-12

    European Space Agency astronaut Pedro Duque of Spain listens to a briefing on mission activities from a Russian trainer at his crew quarters in Baikonur, Kazakhstan, Wednesday, Oct. 15, 2003 as he prepares for his launch to the International Space Station Oct. 18 in a Soyuz TMA-3 vehicle. Photo Credit (NASA/Bill Ingalls)

  15. Expedition 8 Launch Briefing

    NASA Image and Video Library

    2003-10-15

    Expedition 8 Soyuz Commander and Flight Engineer Alexander Kaleri and European Space Agency astronaut Pedro Duque of Spain are briefed on launch procedures from a Russian trainer at their crew quarters in Baikonur, Kazakhstan, Wednesday, Oct. 15, 2003 as they prepare for launch Oct. 18 in a Soyuz TMA-3 vehicle to the International Space Station. Photo Credit (NASA/Bill Ingalls)

  16. Mars Comet Encounter Briefing

    NASA Image and Video Library

    2014-10-09

    Dwayne Brown, NASA public affairs officer, moderates a media briefing where panelists outlined how space and Earth-based assets will be used to image and study comet Siding Spring during its Sunday, Oct. 19 flyby of Mars, Thursday, Oct. 9, 2014 at NASA Headquarters in Washington. Photo Credit: (NASA/Joel Kowsky)

  17. Solar Dynamics Observatory Briefing

    NASA Image and Video Library

    2010-01-21

    Richard Fisher, Heliophysics Division Director at NASA Headquarters, left, speaks during a briefing to discuss the upcoming launch of NASA's Solar Dynamic Observatory, or SDO, Thursday, Jan. 21, 2010, as Madhulika Guhathakurta, SDO Program Scientist looks on at NASA Headquarters in Washington. The mission is to study the Sun and its dynamic behavior. Photo Credit: (NASA/Paul E. Alers)

  18. Solar Dynamics Observatory Briefing

    NASA Image and Video Library

    2010-01-21

    Richard Fisher, Heliophysics Division Director at NASA Headquarters, speaks during a briefing to discuss the upcoming launch of NASA's Solar Dynamic Observatory, or SDO, Thursday, Jan. 21, 2010, at NASA Headquarters in Washington. The mission is to study the Sun and its dynamic behavior. Photo Credit: (NASA/Paul E. Alers)

  19. Solar Dynamics Observatory Briefing

    NASA Image and Video Library

    2010-01-21

    Madhulika Guhathakurta, SDO Program Scientist, speaks during a briefing to discuss the upcoming launch of NASA's Solar Dynamic Observatory, or SDO, Thursday, Jan. 21, 2010, at NASA Headquarters in Washington. The mission is to study the Sun and its dynamic behavior. Photo Credit: (NASA/Paul E. Alers)

  20. The 2007 Legislative Briefing

    ERIC Educational Resources Information Center

    Grove, Jeffrey; Gaines, Gale F., Comp.

    2007-01-01

    "The 2007 Legislative Briefing" is a topical summary of actions during the 2006 legislative sessions that affect education in the 16 SREB states. Topics include state budgets and the economy, tax and revenue, school finance, teacher compensation, licensure, certification and evaluation of teachers, strengthening elementary and secondary…

  1. Orbiting Carbon Observatory Briefing

    NASA Image and Video Library

    2009-01-29

    Anna Michalak, an Orbiting Carbon Observatory science team member from the University of Michigan, Ann Arbor, speaks during a media briefing to discuss the upcoming Orbiting Carbon Observatory mission, the first NASA spacecraft dedicated to studying carbon dioxide, Thursday, Jan. 29, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul E. Alers)

  2. Informatics: A Brief Survey.

    ERIC Educational Resources Information Center

    He, Shaoyi

    2003-01-01

    Provides a brief survey of informatics, defined as the application of information technology to various fields, with respect to its historical background, disciplinary identity, fundamental aspects, applications, and challenges. Highlights include biological, clinical, dental, environmental, geomatics, health, legal, management, medical, museum,…

  3. Research in Brief.

    ERIC Educational Resources Information Center

    Journalism Quarterly, 1984

    1984-01-01

    Brief research reports discuss Latin America as seen on United States network television; television news coverage of federal regulatory agencies; community perceptions of media impressions; active television viewing and cultivation hypothesis; the impact of cable on traditional television news viewing; George Kibbe Turner; advertising; and…

  4. A Brief History.

    ERIC Educational Resources Information Center

    Yalouris, Nicolaos

    1996-01-01

    Provides a brief but concise overview of the historical development of the Olympic Games in ancient Greece. Originally conceived as a one day, single-race event, the Games grew to the point where they represented an apotheosis of Greek culture. Discusses the role played by conflict within the city-states. (MJP)

  5. Cybernetics of Brief Family Therapy.

    ERIC Educational Resources Information Center

    Keeney, Bradford P.; Ross, Jeffrey M.

    1983-01-01

    Presents a cybernetic view of brief family therapy. Includes a historical discussion of the key ideas underlying brief family therapy, a cybernetic model of therapeutic change, and a clinical case for exemplification. (Author/JAC)

  6. Generic School Grounds Design Brief.

    ERIC Educational Resources Information Center

    Dorset County Council, Dorchester (England).

    This document was produced to provide architects, planners, and builders with an educational design brief for Dorset, England school grounds. The County Education Planning and Development Department will use it as an educational and curriculum statement to complement their more detailed and specific building briefs. The brief uses many of the…

  7. Brief therapy: focused solution development.

    PubMed

    De Shazer, S; Berg, I K; Lipchik, E; Nunnally, E; Molnar, A; Gingerich, W; Weiner-Davis, M

    1986-06-01

    This article describes the form of brief therapy developed at the Brief Family Therapy Center. We have chosen a title similar to Weakland, Fisch, Watzlawick, and Bodin's classic paper, "Brief Therapy: Focused Problem Resolution" (20) to emphasize our view that there is a conceptual relationship and a developmental connection between the points of view expressed in the two papers.

  8. Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain.

    PubMed

    Shah, Rachit; Chou, Tsui-Fen; Maize, Kimberly M; Strom, Alexander; Finzel, Barry C; Wagner, Carston R

    2017-09-23

    Human histidine triad nucleotide binding protein 1 (hHint1) is a purine nucleoside phosphoramidase and adenylate hydrolase that has emerged as a potential therapeutic target for the management of pain. However, the molecular mechanism of Hint1 in the signaling pathway has remained less clear. The role of metal ions in regulating postsynaptic transmission is well known, and the active site of hHint1 contains multiple histidines. Here we have investigated the effect of divalent metal ions (Cd(2+), Cu(2+), Mg(2+), Mn(2+), Ni(2+), and Zn(2+)) on the structural integrity and catalytic activity of hHint1. With the exception of Mg(2+), all the divalent ions inhibited hHint1, the rank of order was found to be Cu(2+) >Zn(2+) >Cd(2+) ≥Ni(2+) >Mn(2+) based on their IC50 and kin/KI values. A crystal structure of hHint1 with bound Cu(2+) is described to explain the competitive reversible inactivation of hHint1 by divalent cations. All the metal ions exhibited time- and concentration- dependent inhibition, with the rate of inactivation highly dependent on alterations of the C-terminus. With the exception of Cu(2+); restoration of inhibition was observed for all the metal ions after treatment with EDTA. Our studies reveal a loss in secondary structure and aggregation of hHint1 upon incubation with 10-fold excess of copper. Thus, hHint1 appears to be structurally sensitive to irreversible inactivation by copper, which may be of neurotoxicological and pharmacological significance. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Health Information National Trends Survey in American Sign Language (HINTS-ASL): Protocol for the Cultural Adaptation and Linguistic Validation of a National Survey.

    PubMed

    Kushalnagar, Poorna; Harris, Raychelle; Paludneviciene, Raylene; Hoglind, TraciAnn

    2017-09-13

    The Health Information National Trends Survey (HINTS) collects nationally representative data about the American's public use of health-related information. This survey is available in English and Spanish, but not in American Sign Language (ASL). Thus, the exclusion of ASL users from these national health information survey studies has led to a significant gap in knowledge of Internet usage for health information access in this underserved and understudied population. The objectives of this study are (1) to culturally adapt and linguistically translate the HINTS items to ASL (HINTS-ASL); and (2) to gather information about deaf people's health information seeking behaviors across technology-mediated platforms. We modified the standard procedures developed at the US National Center for Health Statistics Cognitive Survey Laboratory to culturally adapt and translate HINTS items to ASL. Cognitive interviews were conducted to assess clarity and delivery of these HINTS-ASL items. Final ASL video items were uploaded to a protected online survey website. The HINTS-ASL online survey has been administered to over 1350 deaf adults (ages 18 to 90 and up) who use ASL. Data collection is ongoing and includes deaf adult signers across the United States. Some items from HINTS item bank required cultural adaptation for use with deaf people who use accessible services or technology. A separate item bank for deaf-related experiences was created, reflecting deaf-specific technology such as sharing health-related ASL videos through social network sites and using video remote interpreting services in health settings. After data collection is complete, we will conduct a series of analyses on deaf people's health information seeking behaviors across technology-mediated platforms. HINTS-ASL is an accessible health information national trends survey, which includes a culturally appropriate set of items that are relevant to the experiences of deaf people who use ASL. The final HINTS

  10. Galileo Science Writers' Briefing

    NASA Astrophysics Data System (ADS)

    1989-08-01

    This NASA Kennedy video production presents Part 2 of a press conference held at JPL on August 8, 1989. The briefing in its entirety covers the Galileo Project's mission design from launch to completion in 1997 and is moderated by JPL Public Information Mgr. Robert Macmillan. Part 2 of the 3 part video series begins with Richard J. Spehalski's (Galileo Project Manager) description of the spacecraft and mission operations. E. Cherniack gives a slide presentation of a Galileo spacecraft model and some design features unique to the spacecraft. John Givens (Probe System Design Manager) then presents a brief overview of the mission and subsystems surrounding the Galileo Space Probe. Neal E. Ausman, Jr. (Mission Director) ends the video with a discussion of mission operations including slides of the Galileo launch scenario and a trajectory correction maneuver.

  11. Yemen Country Analysis Brief

    EIA Publications

    2014-01-01

    Update: September 30, 2015 Since the publication of the Yemen Country Analysis Brief in September 2014 below, the situation in Yemen has deteriorated significantly. In September 2014, the Shia Houthi rebel group seized the Yemeni capital of Sanaa. In January 2015, the Houthis captured the presidential palace and other strategic buildings, forcing President Hadi and his ministers to resign and to dissolve parliament. In March 2015, a coalition led by Saudi Arabia began airstrikes on Houthi targets, which are still active as of this publication (September 2015). The report below represents the energy situation in Yemen before the Houthi capture of Sanaa and the rest of Yemen. Lack of data and the halting of nearly all energy sector activity in Yemen do not allow for a full update of the Country Analysis Brief.

  12. NASA tech brief evaluations

    NASA Technical Reports Server (NTRS)

    Workman, Gary L.

    1994-01-01

    A major step in transferring technology is to disseminate information about new developments to the appropriate sector(s). A useful vehicle for transferring technology from the government sector to industry has been demonstrated with the use of periodical and journal announcements to highlight technological achievements which may meet the needs of industries other than the one who developed the innovation. To meet this end, NASA has very successfully pursued the goal of identifying technical innovations through the national circulation publication; NASA Tech Briefs. At one time the Technology Utilization Offices of the various centers coordinated the selection of appropriate technologies through a common channel. In recent years, each NASA field center has undertaken the task of evaluating submittals for Tech Brief publication independently of the others. The University of Alabama in Huntsville was selected to assist MSFC in evaluating technology developed under the various programs managed by the NASA center for publication in the NASA Tech Briefs journal. The primary motivation for the NASA Tech Briefs publication is to bring to the attention of industry the various NASA technologies which, in general, have been developed for a specific aerospace requirement, but has application in other areas. Since there are a number of applications outside of NASA that can benefit from innovative concepts developed within the MSPC programs, the ability to transfer technology to other sectors is very high. In most cases, the innovator(s) are not always knowledgeable about other industries which might potentially benefit from their innovation. The evaluation process can therefore contribute to the list of potential users through a knowledgeable evaluator.

  13. Hurricane Hugo briefing

    NASA Astrophysics Data System (ADS)

    Bush, Susan M.

    The effects of Hurricane Hugo could have been much worse, in terms of lives lost and structural damage, according to postdisaster study teams. As part of the National Research Council's Committee on Natural Disasters, teams were sent to the disaster sites almost immediately after Hugo struck on September 18.Meteorologists, wind engineers, coastal geologists, civil engineers, structural engineers, and other members of the study teams presented their findings at a briefing held November 28 in Washington, D.C.

  14. Bioethics: A brief review.

    PubMed

    Mandal, Jharna; Ponnambath, Dinoop Korol; Parija, Subhash Chandra

    2017-01-01

    Medical and life sciences research is a key driver in development, which leads to better quality of life. These pursuits can lead to discrimination, human rights violation, and injustice. The field of bioethics explores the ethical issues arising due to these advances in research and encompasses social, judicial, and environmental aspects affecting human beings. This brief review discusses the origin of bioethics, its principles, various international organizations, and their network involved in the development and propagation of guidelines on conducting biomedical research.

  15. Kepler Media Briefing

    NASA Image and Video Library

    2009-02-19

    William Borucki, principal investigator for Kepler Science at Ames Research Center, Moffett Field, Calif., talks about the Kepler mission during a media briefing, Thursday, Feb. 19, 2008, at NASA Headquarters in Washington. Kepler, the first mission with the ability to find planets like earth, is scheduled to launch on March 5, 2009 from Cape Canaveral Air Force Station, Fla. aboard a Delta II rocket. Photo Credit: (NASA/Paul. E. Alers)

  16. Kepler Media Briefing

    NASA Image and Video Library

    2009-02-19

    Jim Fanson, Kepler project manager, center, talks about the Kepler mission as William Borucki, left, and Debra Fischer, right, listen during a media briefing, Thursday, Feb. 19, 2008, at NASA Headquarters in Washington. Kepler, the first mission with the ability to find planets like earth, is scheduled to launch on March 5, 2009 from Cape Canaveral Air Force Station, Fla. aboard a Delta II rocket. Photo Credit: (NASA/Paul. E. Alers)

  17. Kepler Media Briefing

    NASA Image and Video Library

    2009-02-19

    Debra Fischer, a professor of Astronomy at San Francisco State University, talks about the Kepler mission during a media briefing, Thursday, Feb. 19, 2008, at NASA Headquarters in Washington. Kepler, the first mission with the ability to find planets like earth, is scheduled to launch on March 5, 2009 from Cape Canaveral Air Force Station, Fla. aboard a Delta II rocket. Photo Credit: (NASA/Paul. E. Alers)

  18. Kepler Media Briefing

    NASA Image and Video Library

    2009-02-19

    Jim Fanson, Kepler project manager, at NASA's Jet Propulsion Laboratory in Pasadena, Calif. holds a model of the Kepler spacecraft as he talks about the Kepler mission during a media briefing, Thursday, Feb. 19, 2008, at NASA Headquarters in Washington. Kepler, the first mission with the ability to find planets like earth, is scheduled to launch on March 5, 2009 from Cape Canaveral Air Force Station, Fla. aboard a Delta II rocket. Photo Credit: (NASA/Paul. E. Alers)

  19. Kepler Media Briefing

    NASA Image and Video Library

    2009-02-19

    Jim Fanson, Kepler project manager, right, talks about the Kepler mission as William Borucki, left, listens during a media briefing, Thursday, Feb. 19, 2008, at NASA Headquarters in Washington. Kepler, the first mission with the ability to find planets like earth, is scheduled to launch on March 5, 2009 from Cape Canaveral Air Force Station, Fla. aboard a Delta II rocket. Photo Credit: (NASA/Paul. E. Alers)

  20. Kepler Media Briefing

    NASA Image and Video Library

    2009-02-19

    William Borucki, principal investigator for Kepler Science at Ames Research Center, Moffett Field, Calif., second from left, is seen through a television camer monitor as he talks about the Kepler mission during a media briefing, Thursday, Feb. 19, 2008, at NASA Headquarters in Washington. Kepler, the first mission with the ability to find planets like earth, is scheduled to launch on March 5, 2009 from Cape Canaveral Air Force Station, Fla. aboard a Delta II rocket. Photo Credit: (NASA/Paul. E. Alers)

  1. Kepler Media Briefing

    NASA Image and Video Library

    2009-02-19

    Jon Morse, director, Astrophysics Division at NASA Headquarters talks about the Kepler mission during a media briefing, Thursday, Feb. 19, 2008, at NASA Headquarters in Washington. Kepler, the first mission with the ability to find planets like earth, is scheduled to launch on March 5, 2009 from Cape Canaveral Air Force Station, Fla. aboard a Delta II rocket. Photo Credit: (NASA/Paul. E. Alers)

  2. Kepler Media Briefing

    NASA Image and Video Library

    2009-02-19

    Jim Fanson, Kepler project manager, at NASA's Jet Propulsion Laboratory in Pasadena, Calif. talks about the Kepler mission during a media briefing, Thursday, Feb. 19, 2008, at NASA Headquarters in Washington. Kepler, the first mission with the ability to find planets like earth, is scheduled to launch on March 5, 2009 from Cape Canaveral Air Force Station, Fla. aboard a Delta II rocket. Photo Credit: (NASA/Paul. E. Alers)

  3. Strategic forces briefing

    SciTech Connect

    Bing, G.; Chrzanowski, P.; May, M.; Nordyke, M.

    1989-04-06

    The Strategic Forces Briefing'' is our attempt, accomplished over the past several months, to outline and highlight the more significant strategic force issues that must be addressed in the near future. Some issues are recurrent: the need for an effective modernized Triad and a constant concern for force survivability. Some issues derive from arms control: the Strategic Arms Reduction Talks (SALT) are sufficiently advanced to set broad numerical limits on forces, but not so constraining as to preclude choices among weapon systems and deployment modes. Finally, a new administration faced with serious budgetary problems must strive for the most effective strategic forces limited dollars can buy and support. A review of strategic forces logically begins with consideration of the missions the forces are charged with. We begin the briefing with a short review of targeting policy and implementation within the constraints of available unclassified information. We then review each element of the Triad with sections on SLBMs, ICBMs, and Air-Breathing (bomber and cruise missile) systems. A short section at the end deals with the potential impact of strategic defense on offensive force planning. We consider ABM, ASAT, and air defense; but we do not attempt to address the technical issues of strategic defense per se. The final section gives a brief overview of the tritium supply problem. We conclude with a summary of recommendations that emerge from our review. The results of calculation on the effectiveness of various weapon systems as a function of cost that are presented in the briefing are by Paul Chrzanowski.

  4. GRAIL Mission Briefing

    NASA Image and Video Library

    2011-08-25

    On the panel from right: Leesa Hubbard, teacher in residence, Sally Ride Science, San Diego; David Lehman, GRAIL project manager, NASA's Jet Propulsion Laboratory, Pasadena, Calif.; Maria Zuber, GRAIL principal investigator, Massachusetts Institute of Technology, Cambridge and Jim Green, director, Planetary Science Division, NASA Headquarters, Washington are seen at a press briefing to discuss the upcoming launch to the moon of the Gravity Recovery and Interior Laboratory (GRAIL) mission, Thursday, Aug. 25, 2011 in Washington. Photo Credit: (NASA/Carla Cioffi)

  5. Diagnosing Stroke in Acute Vertigo: The HINTS Family of Eye Movement Tests and the Future of the "Eye ECG".

    PubMed

    Newman-Toker, David E; Curthoys, Ian S; Halmagyi, G Michael

    2015-10-01

    Patients who present to the emergency department with symptoms of acute vertigo or dizziness are frequently misdiagnosed. Missed opportunities to promptly treat dangerous strokes can result in poor clinical outcomes. Inappropriate testing and incorrect treatments for those with benign peripheral vestibular disorders leads to patient harm and unnecessary costs. Over the past decade, novel bedside approaches to diagnose patients with the acute vestibular syndrome have been developed and refined. A battery of three bedside tests of ocular motor physiology known as "HINTS" (head impulse, nystagmus, test of skew) has been shown to identify acute strokes more accurately than even magnetic resonance imaging with diffusion-weighted imaging (MRI-DWI) when applied in the early acute period by eye-movement specialists. Recent advances in lightweight, high-speed video-oculography (VOG) technology have made possible a future in which HINTS might be applied by nonspecialists in frontline care settings using portable VOG. Use of technology to measure eye movements (VOG-HINTS) to diagnose stroke in the acute vestibular syndrome is analogous to the use of electrocardiography (ECG) to diagnose myocardial infarction in acute chest pain. This "eye ECG" approach could transform care for patients with acute vertigo and dizziness around the world. In the United States alone, successful implementation would likely result in improved quality of emergency care for hundreds of thousands of peripheral vestibular patients and tens of thousands of stroke patients, as well as an estimated national health care savings of roughly $1 billion per year. In this article, the authors review the origins of the HINTS approach, empiric evidence and pathophysiologic principles supporting its use, and possible uses for the eye ECG in teleconsultation, teaching, and triage.

  6. Development and Validation of a Novel Generic Health-related Quality of Life Instrument With 20 Items (HINT-20)

    PubMed Central

    2017-01-01

    Objectives Few attempts have been made to develop a generic health-related quality of life (HRQoL) instrument and to examine its validity and reliability in Korea. We aimed to do this in our present study. Methods After a literature review of existing generic HRQoL instruments, a focus group discussion, in-depth interviews, and expert consultations, we selected 30 tentative items for a new HRQoL measure. These items were evaluated by assessing their ceiling effects, difficulty, and redundancy in the first survey. To validate the HRQoL instrument that was developed, known-groups validity and convergent/discriminant validity were evaluated and its test-retest reliability was examined in the second survey. Results Of the 30 items originally assessed for the HRQoL instrument, four were excluded due to high ceiling effects and six were removed due to redundancy. We ultimately developed a HRQoL instrument with a reduced number of 20 items, known as the Health-related Quality of Life Instrument with 20 items (HINT-20), incorporating physical, mental, social, and positive health dimensions. The results of the HINT-20 for known-groups validity were poorer in women, the elderly, and those with a low income. For convergent/discriminant validity, the correlation coefficients of items (except vitality) in the physical health dimension with the physical component summary of the Short Form 36 version 2 (SF-36v2) were generally higher than the correlations of those items with the mental component summary of the SF-36v2, and vice versa. Regarding test-retest reliability, the intraclass correlation coefficient of the total HINT-20 score was 0.813 (p<0.001). Conclusions A novel generic HRQoL instrument, the HINT-20, was developed for the Korean general population and showed acceptable validity and reliability. PMID:28173686

  7. 12 CFR 622.14 - Briefs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Briefs. 622.14 Section 622.14 Banks and Banking... Formal Hearings § 622.14 Briefs. (a) Contents. Any brief filed in a proceeding shall be confined to the... briefs. Reply briefs may be filed within 10 days after service of original briefs of opposing parties...

  8. 4 CFR 28.60 - Briefs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Briefs. 28.60 Section 28.60 Accounts GOVERNMENT... Hearings § 28.60 Briefs. (a) Length. Principal briefs shall not exceed 60 pages and reply briefs 30 pages... extended briefs shall be granted only for good cause shown. Briefs in excess of 10 pages shall include an...

  9. Precursory Hints of June 23-2001 Earthquake in Southern Peru Seismic Gap

    NASA Astrophysics Data System (ADS)

    Ocola, L.

    2001-12-01

    On June 23, 2001, a destructive 8.3 Mw, shallow depth, shallow-dip thrust-mechanism earthquake shook southern Peru. The hypocenter was located under the ocean floor, at the northern end of the southern Peru seismic gap. The gap is about 500 km long, located between 16\\deg-19\\deg S, parallel to Peru-Chile trench. It delineates the rupture zone of the 1868, 9.0-9.3 Mw, earthquake; the largest historically documented "terremoto" in this region. This gap and the northern Chile gap have been known for several decades and they belong to a normal-subduction segment delimited by the Nazca-Abancay (northern end) and Copiapo-Tucuman (southern end) contortions of the Wadati-Benioff subduction zone. The Peru-Chile trench and the Central Andean Active Volcanic Zone axis run nearly parallel to each other in this subduction segment. Regional seismicity (1999-2000) was the clearest indicator of the proximity of incoming event. It showed a striking deficiency of activity in the southern Peru gap region which has a good spatial correlation with a negative anomaly of the rate of change of the GPS vertical component in, approximately, the same region. Since it was not possible to issue a prediction on the incoming event, an hypothetical scenario was computed for a 9.3 Mw earthquake and reported to the Civil Defense Agency in order to implement preventive measures for disaster mitigation. The June 23-2001, 8.3 Mw , earthquake occurred in the northern extreme of the hypothetical rupture zone. However, about one half of the rupture zone is to go in the near future to cover the 1868-earthquake equivalent rupture zone. In summary, the following precursory hints could be identified before the June 23-2001 earthquake: Deficiency of regional seismic activity, negative tendency on the rate of change of the GPS vertical component, seismicity on the near surface fault system in the gap region.

  10. Mars Comet Encounter Briefing

    NASA Image and Video Library

    2014-10-09

    Jim Green, director, Planetary Science Division, NASA Headquarters, Washington, left, is seen with fellow panelists Carey Lisse, senior astrophysicist, Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland, Kelly Fast, program scientist, Planetary Science Division, NASA Headquarters, Washington, and Padma Yanamandra-Fisher, senior research scientist, Space Science Institute, Rancho Cucamonga Branch, California during a media briefing where they outlined how space and Earth-based assets will be used to image and study comet Siding Spring during its Sunday, Oct. 19 flyby of Mars, Thursday, Oct. 9, 2014 at NASA Headquarters in Washington. Photo Credit: (NASA/Joel Kowsky)

  11. Mars Comet Encounter Briefing

    NASA Image and Video Library

    2014-10-09

    Dwayne Brown, NASA public affairs officer, left, moderates a media briefing where panelist, seated from left, Jim Green, director, Planetary Science Division, NASA Headquarters, Washington, Carey Lisse, senior astrophysicist, Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland, Kelly Fast, program scientist, Planetary Science Division, NASA Headquarters, Washington, and Padma Yanamandra-Fisher, senior research scientist, Space Science Institute, Rancho Cucamonga Branch, California, outlined how space and Earth-based assets will be used to image and study comet Siding Spring during its Sunday, Oct. 19 flyby of Mars, Thursday, Oct. 9, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Joel Kowsky)

  12. Mars Comet Encounter Briefing

    NASA Image and Video Library

    2014-10-09

    Panelists, from left, Jim Green, director, Planetary Science Division, NASA Headquarters, Washington, Carey Lisse, senior astrophysicist, Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland, Kelly Fast, program scientist, Planetary Science Division, NASA Headquarters, Washington, and Padma Yanamandra-Fisher, senior research scientist, Space Science Institute, Rancho Cucamonga Branch, California, are seen during a media briefing where they outlined how space and Earth-based assets will be used to image and study comet Siding Spring during its Sunday, Oct. 19 flyby of Mars, Thursday, Oct. 9, 2014 at NASA Headquarters in Washington. (Photo credit: NASA/Joel Kowsky)

  13. A Brief Report

    PubMed Central

    Ali, Ather; Vitulano, Lawrence A.

    2010-01-01

    The 2010 Yale Research Symposium on Complementary and Integrative Medicine highlighted original research in related areas by Yale faculty and provided a forum to discuss and debate issues of evidence and plausibility. In this brief report, we describe selected presentations on such diverse foci as nutritional influences on cancer, acupuncture for low back pain, protein intake’s effects on bone consumption, Chinese herb-derived adjuvant chemotherapy, and the relationship between anger and cardiac arrhythmia. This symposium demonstrated that rigorous research methods are being used to study unconventional therapies and that an integrative medicine approach requires a solid scientific foundation. PMID:20885898

  14. Odontome: A Brief Overview

    PubMed Central

    Prabhadevi, Maganur C; Sharma, Rajesh

    2011-01-01

    Odontomas are the most common type of odontogenic tumors. They are included under the benign calcified odontogenic tumors. Odontomas are basically classified into two types, complex and compound odontomes. Various theories or etiological factors are been quoted for the occurrence of odontomes. Generally, they are asymptomatic. Occasionally, signs and symptoms relating to their presence do occur. The sole management depends upon the early diagnosis, histopathological examination and excision of these tissues. This article briefs regarding its classification, etiological factors, occurrence, differences between complex and compound odontomes, diagnosis and management. PMID:27678223

  15. Kepler Media Briefing

    NASA Image and Video Library

    2009-02-19

    Debra Fischer, a professor of Astronomy at San Francisco State University, right, makes a comment, as Jim Fanson, William Borucki and Jon Morse, fourth from right, look on during a media briefing on the Kepler mission, Thursday, Feb. 19, 2008, at NASA Headquarters in Washington. Kepler, the first mission with the ability to find planets like earth, is scheduled to launch on March 5, 2009 from Cape Canaveral Air Force Station, Fla. aboard a Delta II rocket. At far left is J.D. Harrington. Photo Credit: (NASA/Paul. E. Alers)

  16. Radioimmunotherapy: a brief overview

    PubMed Central

    Ng, DCE

    2006-01-01

    With the advent of biotechnological advances and knowledge of molecular and cellular biology, radioimmunotherapy (RIT) has become a highly promising oncologic therapeutic modality with established clinically efficacy, particularly in non-Hodgkin’s lymphomas. This paper provides a short survey of the basic science of RIT and the various monoclonal antibodies and radionuclides used. A brief review of the published literature on the clinical applications of radioimmunotherapy, particularly in non-Hodgkin’s lymphoma, is provided. New research data indicate many potential areas of development of this modality, including haematological and solid-organ radioimmunotherapy as well as new radionuclidic approaches and clinical protocols. PMID:21614238

  17. Hurricane Gilbert briefing

    NASA Astrophysics Data System (ADS)

    Bush, Susan M.

    Hurricane Gilbert has been called one of the most monstrous hurricanes of the 20th century, cutting a nearly 2000-mile swath across Jamaica, Mexico's Yucatan Peninsula, and along the border of Texas and Mexico September 10-17. Death toll was about 200, and damage estimates were above $8 billion.A briefing on the effects of Gilbert was held in Washington, D.C., on October 24. It was sponsored by the Committee on Natural Disasters of the National Academy of Sciences, with the Office of U.S. Foreign Disaster Assistance and the National Oceanic and Atmospheric Administration.

  18. NuSTAR Briefing

    NASA Image and Video Library

    2012-05-30

    Yunjin Kim, NuSTAR project manager at the Jet Propulsion Laborartory (JPL), talks about NASA's Spectroscopic Telescope Array (NuStar) during a briefing, Wednesday, May 30, 2012, at NASA Headquarters in Washington. Imaging light in the high-energy, short-wavelength X-ray range, the telescope will aim to study how black holes form and evolve along with galaxies. The instrument, packed aboard an Orbital Sciences Pegasus XL rocket is set to launch from a plane in midair no earlier than June 13 from Kwajalein Atoll in the Marshall Islands. Photo Credit: (NASA/Paul E. Alers)

  19. GRAIL Mission Briefing

    NASA Image and Video Library

    2011-08-25

    Maria Zuber, GRAIL principal investigator, Massachusetts Institute of Technology, Cambridge, answers a reporter's question at a press briefing about the upcoming launch to the moon of the Gravity Recovery and Interior Laboratory (GRAIL) mission, Thursday, Aug. 25, 2011 in Washington. GRAIL's primary science objectives are to determine the structure of the lunar interior, from crust to core, and to advance understanding of the thermal evolution of the moon. The mission will place two spacecraft into the same orbit around the moon which will gather information about the its gravitational field enabling scientists to create a high-resolution map. Photo Credit: (NASA/Carla Cioffi)

  20. Neurolaw: A brief introduction

    PubMed Central

    Petoft, Arian

    2015-01-01

    Neurolaw, as an interdisciplinary field which links the brain to law, facilitates the pathway to better understanding of human behavior in order to regulate it accurately through incorporating neuroscience achievements in legal studies. Since 1990’s, this emerging field, by study on human nervous system as a new dimension of legal phenomena, leads to a more precise explanation for human behavior to revise legal rules and decision-makings. This paper strives to bring about significantly a brief introduction to neurolaw so as to take effective steps toward exploring and expanding the scope of law and more thorough understanding of legal issues in the field at hand. PMID:25874060

  1. Annual Research Briefs - 2006

    DTIC Science & Technology

    2006-12-01

    a round liq- uid jet by a coaxial flow of gas. D. KIM, 0. DESJARDINS, MI. HERRMANN AND P. MOIN 185 Stable and high-order accurate finite difference...Research 185 Annual Research Briefs 2006 Toward two-phase simulation of the primary breakup of a round liquid jet by a coaxial flow of gas By D. Kim, 0...gas phase. The flow solver volume fraction i) is defined as The breakup of a round liquid jet by a coaxial flow of gas 187 Vi = ’ H(G)dV, (2.9) where

  2. Smartphone Ownership Among US Adult Cigarette Smokers: 2014 Health Information National Trends Survey (HINTS) Data.

    PubMed

    Heffner, Jaimee L; Mull, Kristin E

    2017-08-31

    Despite increasing interest in smartphone apps as a platform for delivery of tobacco cessation interventions, no previous studies have evaluated the prevalence and characteristics of smokers who can access smartphone-delivered interventions. To guide treatment development in this new platform and to evaluate disparities in access to smartphone-delivered interventions, we examined associations of smartphone ownership with demographics, tobacco use and thoughts about quitting, other health behaviors, physical and mental health, health care access, and Internet and technology utilization using a nationally representative sample of US adult smokers. Data were from the National Cancer Institute's 2014 Health Information National Trends Survey 4 (HINTS 4), Cycle 4. This mailed survey targeted noninstitutionalized individuals aged 18 years or older using two-stage stratified random sampling. For this analysis, we restricted the sample to current smokers with complete data on smartphone ownership (n=479). Nearly two-thirds (weighted percent=63.8%, 248/479) of smokers reported owning a smartphone. Those who were younger (P<.001), employed (P=.002), never married (P=.002), and had higher education (P=.002) and income (P<.001) had the highest rates of ownership. Smartphone owners did not differ from nonowners on frequency of smoking, recent quit attempts, or future plans to quit smoking, although they reported greater belief in the benefits of quitting (P=.04). Despite being equally likely to be overweight or obese, smartphone owners reported greater fruit and vegetable consumption (P=.03) and were more likely to report past-year efforts to increase exercise (P=.001) and to lose weight (P=.02). No differences in health care access and utilization were found. Smartphone owners reported better physical and mental health in several domains and higher access to and utilization of technology and the Internet, including for health reasons. Smartphone ownership among smokers mirrors

  3. Smartphone Ownership Among US Adult Cigarette Smokers: 2014 Health Information National Trends Survey (HINTS) Data

    PubMed Central

    Mull, Kristin E

    2017-01-01

    Background Despite increasing interest in smartphone apps as a platform for delivery of tobacco cessation interventions, no previous studies have evaluated the prevalence and characteristics of smokers who can access smartphone-delivered interventions. Objective To guide treatment development in this new platform and to evaluate disparities in access to smartphone-delivered interventions, we examined associations of smartphone ownership with demographics, tobacco use and thoughts about quitting, other health behaviors, physical and mental health, health care access, and Internet and technology utilization using a nationally representative sample of US adult smokers. Methods Data were from the National Cancer Institute’s 2014 Health Information National Trends Survey 4 (HINTS 4), Cycle 4. This mailed survey targeted noninstitutionalized individuals aged 18 years or older using two-stage stratified random sampling. For this analysis, we restricted the sample to current smokers with complete data on smartphone ownership (n=479). Results Nearly two-thirds (weighted percent=63.8%, 248/479) of smokers reported owning a smartphone. Those who were younger (P<.001), employed (P=.002), never married (P=.002), and had higher education (P=.002) and income (P<.001) had the highest rates of ownership. Smartphone owners did not differ from nonowners on frequency of smoking, recent quit attempts, or future plans to quit smoking, although they reported greater belief in the benefits of quitting (P=.04). Despite being equally likely to be overweight or obese, smartphone owners reported greater fruit and vegetable consumption (P=.03) and were more likely to report past-year efforts to increase exercise (P=.001) and to lose weight (P=.02). No differences in health care access and utilization were found. Smartphone owners reported better physical and mental health in several domains and higher access to and utilization of technology and the Internet, including for health reasons

  4. PsHint1, associated with the G-protein α subunit PsGPA1, is required for the chemotaxis and pathogenicity of Phytophthora sojae.

    PubMed

    Zhang, Xin; Zhai, Chunhua; Hua, Chenlei; Qiu, Min; Hao, Yujuan; Nie, Pingping; Ye, Wenwu; Wang, Yuanchao

    2016-02-01

    Zoospore chemotaxis to soybean isoflavones is essential in the early stages of infection by the oomycete pathogen Phytophthora sojae. Previously, we have identified a G-protein α subunit encoded by PsGPA1 which regulates the chemotaxis and pathogenicity of P. sojae. In the present study, we used affinity purification to identify PsGPA1-interacting proteins, including PsHint1, a histidine triad (HIT) domain-containing protein orthologous to human HIT nucleotide-binding protein 1 (HINT1). PsHint1 interacted with both the guanosine triphosphate (GTP)- and guanosine diphosphate (GDP)-bound forms of PsGPA1. An analysis of the gene-silenced transformants revealed that PsHint1 was involved in the chemotropic response of zoospores to the isoflavone daidzein. During interaction with a susceptible soybean cultivar, PsHint1-silenced transformants displayed significantly reduced infectious hyphal extension and caused a strong cell death in plants. In addition, the transformants displayed defective cyst germination, forming abnormal germ tubes that were highly branched and exhibited apical swelling. These results suggest that PsHint1 not only regulates chemotaxis by interacting with PsGPA1, but also participates in a Gα-independent pathway involved in the pathogenicity of P. sojae. © 2015 BSPP AND JOHN WILEY & SONS LTD.

  5. Building Confidence through Brief Therapy.

    ERIC Educational Resources Information Center

    Stanton, Harry E.

    1991-01-01

    The usefulness of brief therapy techniques in helping adults build confidence is asserted. Techniques described are clenched fist, split screen, submodalities, Swish, and theater technique for phobias. (SK)

  6. Brief resolved unexplained event

    PubMed Central

    Arane, Karen; Claudius, Ilene; Goldman, Ran D.

    2017-01-01

    Abstract Question For many years, the term apparent life-threatening event (ALTE) was associated with sudden infant death syndrome, and parents who described an acute event in their infants were sent to the hospital for admission. I understand that for infants new terminology is recommended. What is the current approach to a near-death experience of an infant? Answer A recent clinical practice guideline revised the name and definition of an ALTE to a brief resolved unexplained event (BRUE). The diagnosis of BRUE in infants younger than 1 year of age is made when infants experience 1 of the following BRUE symptoms: a brief episode (ie, less than 1 minute and usually less than 20 to 30 seconds) that is entirely resolved (infant is at baseline), which remains unexplained after the history and physical examination are completed, and includes an event characterized by cyanosis or pallor; absent, decreased, or irregular breathing; hypertonia or hypotonia; or altered responsiveness. Low-risk infants should not be admitted to the hospital and overtesting is discouraged. PMID:28115439

  7. Amachi In Brief. P/PV In Brief. Issue 1

    ERIC Educational Resources Information Center

    Farley, Chelsea

    2004-01-01

    This first issue in P/PV's "In Brief" series focuses on the Amachi program, which partners faith-based organizations with public agencies and nonprofit service providers to identify the children of prisoners and match them with caring adult volunteers. "Amachi In Brief" touches on the program's development and recruiting…

  8. 17 CFR 9.23 - Answering brief.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Answering brief. 9.23 Section... Appeals § 9.23 Answering brief. (a) Time for filing answering brief. Within thirty days after service of the appeal brief, the exchange must file with the Commission an answering brief. (b) Contents of...

  9. 24 CFR 1720.615 - Reply brief.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Reply brief. 1720.615 Section 1720... Proceedings Appeals § 1720.615 Reply brief. A brief in reply to an answering brief, limited to rebuttal of matters in the answering brief, may be filed and served by a party within 7 days after receipt of the...

  10. 7 CFR 15.135 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Posthearing briefs. 15.135 Section 15.135 Agriculture... Posthearing briefs. The hearing officer shall fix a reasonable time for filing posthearing briefs, which may contain proposed findings of fact and conclusions of law, and, if permitted, reply briefs. Briefs should...

  11. A Brief Taxometrics Primer

    PubMed Central

    Beauchaine, Theodore P.

    2009-01-01

    Taxometric procedures provide an empirical means of determining which psychiatric disorders are typologically distinct from normal behavioral functioning. Although most disorders reflect extremes along continuously distributed behavioral traits, identifying those that are discrete has important implications for accurate diagnosis, effective treatment, early identification of risk, and improved understanding of etiology. This article provides (a) brief descriptions of the conceptual bases of several taxometric procedures, (b) example analyses using simulated data, and (c) strategies for avoiding common pitfalls that are often observed in taxometrics research. To date, most taxometrics studies have appeared in the adult psychopathology literature. It is hoped that this primer will encourage interested readers to extend taxometrics research to child and adolescent populations. PMID:18088222

  12. SOHO Mission Science Briefing

    NASA Technical Reports Server (NTRS)

    1995-01-01

    Footage shows the SOHO Mission Pre-Launch Science Briefing. The moderator of the conference is Fred Brown, NASA/GSFC Public Affairs, introduces the panel members. Included are Professor Roger Bonnet, Director ESA Science Program, Dr. Wesley Huntress, Jr., NASA Associate Administrator for Space Science and Dr. Vicente Domingo, ESA SOHO Project Scientist. Also present are several members from the SOHO Team: Dr. Richard Harrison, Art Poland, and Phillip Scherrer. The discussions include understanding the phenomena of the sun, eruption of gas clouds into the atmosphere, the polishing of the mirrors for the SOHO satellite, artificial intelligence in the telescopes, and the launch and operating costs. The panel members are also seen answering questions from various NASA Centers and Paris.

  13. Galileo Science Writers' Briefing

    NASA Astrophysics Data System (ADS)

    1989-08-01

    This NASA Kennedy video production presents Part 3 of a press conference held at JPL on August 8, 1989. The briefing in its entirety covers the Galileo Project's mission design from launch to completion in 1997 and is moderated by JPL Public Information Mgr. Robert Macmillan. Part 3 of the 3 part video series centers on the Galileo science goals, which are to explore not only Jupiter but the entire Jovian system, and the individual instruments that will make these objectives possible. Dr. Torrence V. Johnson (Project Scientist) introduces Dr. Richard Young (Probe Scientist (AMES)) and Dr. Clayne M. Yeates (Acting Science Mission Design Manager) who discuss the six main instruments included on the Probe and the Orbiter experiments and instrumentation, respectively. The video is rounded out by a period in which the Science Writer's are given an opportunity to ask questions of the seven member panel.

  14. Performance-Based Funding Brief

    ERIC Educational Resources Information Center

    Washington Higher Education Coordinating Board, 2011

    2011-01-01

    A number of states have made progress in implementing performance-based funding (PFB) and accountability. This policy brief summarizes main features of performance-based funding systems in three states: Tennessee, Ohio, and Indiana. The brief also identifies key issues that states considering performance-based funding must address, as well as…

  15. Legal Briefs for School Administrators.

    ERIC Educational Resources Information Center

    Strahan, Richard Dobbs

    The legal briefs in this volume provide insights into operational problems for a practicing administrator. Fifteen briefs provide some general policy statements that appear to be sound practice for the areas covered. In addition, each section propounds questions that are commonly asked by school people. The author has attempted to attack each…

  16. New Mexico: State Policy Brief

    ERIC Educational Resources Information Center

    Corbett, Julie

    2015-01-01

    This brief is one in a series highlighting state policies, regulations, practices, laws, or other tools intended to create the necessary conditions for school and/or district turnaround. Each brief includes an overview of the relevant turnaround tool, its development process, its impact, and lessons learned that could assist other education…

  17. Galileo Mission Science Briefing

    NASA Technical Reports Server (NTRS)

    1989-01-01

    The first of two tapes of the Galileo Mission Science press briefing is presented. The panel is moderated by George Diller from the Kennedy Space Center (KSC) Public Affairs Office. The participants are John Conway, the director of Payload and operations at Kennedy; Donald E. Williams, Commander of STS-43, the shuttle mission which will launch the Galileo mission; John Casani, the Deputy Assistant Director of Flight Projects at the Jet Propulsion Lab (JPL); Dick Spehalski, Galileo Project Manager at JPL; and Terrence Johnson, Galileo Project Scientist at JPL. The briefing begins with an announcement of the arrival of the Galileo Orbiter at KSC. The required steps prior to the launch are discussed. The mission trajectory and gravity assists from planetary and solar flybys are reviewed. Detailed designs of the orbiter are shown. The distance that Galileo will travel from the sun precludes the use of solar energy for heat. Therefore Radioisotope heater units are used to keep the equipment at operational temperature. A video of the arrival of the spacecraft at KSC and final tests and preparations is shown. Some of the many science goals of the mission are reviewed. Another video showing an overview of the Galileo mission is presented. During the question and answer period, the issue of the use of plutonium on the mission is broached, which engenders a review of the testing methods used to ensure the safety of the capsules containing the hazardous substance. This video has actual shots of the orbiter, as it is undergoing the final preparations and tests for the mission.

  18. Galileo Mission Science Briefing

    NASA Astrophysics Data System (ADS)

    1989-07-01

    The first of two tapes of the Galileo Mission Science press briefing is presented. The panel is moderated by George Diller from the Kennedy Space Center (KSC) Public Affairs Office. The participants are John Conway, the director of Payload and operations at Kennedy; Donald E. Williams, Commander of STS-43, the shuttle mission which will launch the Galileo mission; John Casani, the Deputy Assistant Director of Flight Projects at the Jet Propulsion Lab (JPL); Dick Spehalski, Galileo Project Manager at JPL; and Terrence Johnson, Galileo Project Scientist at JPL. The briefing begins with an announcement of the arrival of the Galileo Orbiter at KSC. The required steps prior to the launch are discussed. The mission trajectory and gravity assists from planetary and solar flybys are reviewed. Detailed designs of the orbiter are shown. The distance that Galileo will travel from the sun precludes the use of solar energy for heat. Therefore Radioisotope heater units are used to keep the equipment at operational temperature. A video of the arrival of the spacecraft at KSC and final tests and preparations is shown. Some of the many science goals of the mission are reviewed. Another video showing an overview of the Galileo mission is presented. During the question and answer period, the issue of the use of plutonium on the mission is broached, which engenders a review of the testing methods used to ensure the safety of the capsules containing the hazardous substance. This video has actual shots of the orbiter, as it is undergoing the final preparations and tests for the mission.

  19. Increased PKC activity and altered GSK3β/NMDAR function drive behavior cycling in HINT1-deficient mice: bipolarity or opposing forces

    PubMed Central

    Garzón-Niño, Javier; Rodríguez-Muñoz, María; Cortés-Montero, Elsa; Sánchez-Blázquez, Pilar

    2017-01-01

    Mice with histidine triad nucleotide-binding protein 1 (HINT1) deletion exhibit manic-like symptoms that evolve into depressive-like behavior in response to stressful paradigms. Molecular and electrophysiological studies have indicated that HINT1−/− mice exhibit increased PKC, PKA, and GSK3β activities, as well as glutamate N-methyl-D-aspartate receptor (NMDAR)/α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptor (AMPAR) and NR2B/NR2A subunit ratios. Pharmacological interventions stabilized their behavior but through different mechanisms. GSK3β inhibitors and valproate directly attenuated the expression of the manic-like symptoms, whereas PKC inhibition, lamotrigine, or risperidone promoted NMDAR-mediated depressive-like behaviors that counterbalanced the preexisting manic-like symptoms. Naïve HINT1−/− mice exposed to stressful paradigms rapidly manifested depressive-like behaviors in subsequent stressful situations, a capacity that persisted for a couple of weeks thereafter. During the depressive-like phase, citalopram, amitriptyline and MK801 precipitated manic-like behaviors in stressed HINT1−/− mice. Notably, the antagonism of NMDARs prevented HINT1−/− mice from alternating behaviors in response to stress. A comparison with “manic” Black Swiss mice indicated that in HINT1−/− mice, PKC supports manic-like symptoms and reduces the expression of depressive-like behaviors via activation of GSK3β and regulation of NR2B-enriched NMDARs. HINT1−/− mice represent a suitable model for studying human BPD and may facilitate the identification of novel targets and drugs to treat this mental disorder. PMID:28240305

  20. Increased PKC activity and altered GSK3β/NMDAR function drive behavior cycling in HINT1-deficient mice: bipolarity or opposing forces.

    PubMed

    Garzón-Niño, Javier; Rodríguez-Muñoz, María; Cortés-Montero, Elsa; Sánchez-Blázquez, Pilar

    2017-02-27

    Mice with histidine triad nucleotide-binding protein 1 (HINT1) deletion exhibit manic-like symptoms that evolve into depressive-like behavior in response to stressful paradigms. Molecular and electrophysiological studies have indicated that HINT1(-/-) mice exhibit increased PKC, PKA, and GSK3β activities, as well as glutamate N-methyl-D-aspartate receptor (NMDAR)/α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptor (AMPAR) and NR2B/NR2A subunit ratios. Pharmacological interventions stabilized their behavior but through different mechanisms. GSK3β inhibitors and valproate directly attenuated the expression of the manic-like symptoms, whereas PKC inhibition, lamotrigine, or risperidone promoted NMDAR-mediated depressive-like behaviors that counterbalanced the preexisting manic-like symptoms. Naïve HINT1(-/-) mice exposed to stressful paradigms rapidly manifested depressive-like behaviors in subsequent stressful situations, a capacity that persisted for a couple of weeks thereafter. During the depressive-like phase, citalopram, amitriptyline and MK801 precipitated manic-like behaviors in stressed HINT1(-/-) mice. Notably, the antagonism of NMDARs prevented HINT1(-/-) mice from alternating behaviors in response to stress. A comparison with "manic" Black Swiss mice indicated that in HINT1(-/-) mice, PKC supports manic-like symptoms and reduces the expression of depressive-like behaviors via activation of GSK3β and regulation of NR2B-enriched NMDARs. HINT1(-/-) mice represent a suitable model for studying human BPD and may facilitate the identification of novel targets and drugs to treat this mental disorder.

  1. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human histidine triad nucleotide-binding protein 2 (hHINT2)

    PubMed Central

    Dolot, Rafał; Włodarczyk, Artur; Bujacz, Grzegorz D.; Nawrot, Barbara

    2013-01-01

    Histidine triad nucleotide-binding protein 2 (HINT2) is a mitochondrial adenosine phosphoramidase mainly expressed in the pancreas, liver and adrenal gland. HINT2 possibly plays a role in apoptosis, as well as being involved in steroid biosynthesis, hepatic lipid metabolism and regulation of hepatic mitochondria function. The expression level of HINT2 is significantly down-regulated in hepatocellular carcinoma patients. To date, endogenous substrates for this enzyme, as well as the three-dimensional structure of human HINT2, are unknown. In this study, human HINT2 was cloned, overexpressed in Escherichia coli and purified. Crystallization was performed at 278 K using PEG 4000 as the main precipitant; the crystals, which belonged to the tetragonal space group P41212 with unit-cell parameters a = b = 76.38, c = 133.25 Å, diffracted to 2.83 Å resolution. Assuming two molecules in the asymmetric unit, the Matthews coefficient and the solvent content were calculated to be 2.63 Å3 Da−1 and 53.27%, respectively. PMID:23832208

  2. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human histidine triad nucleotide-binding protein 2 (hHINT2).

    PubMed

    Dolot, Rafał; Włodarczyk, Artur; Bujacz, Grzegorz D; Nawrot, Barbara

    2013-07-01

    Histidine triad nucleotide-binding protein 2 (HINT2) is a mitochondrial adenosine phosphoramidase mainly expressed in the pancreas, liver and adrenal gland. HINT2 possibly plays a role in apoptosis, as well as being involved in steroid biosynthesis, hepatic lipid metabolism and regulation of hepatic mitochondria function. The expression level of HINT2 is significantly down-regulated in hepatocellular carcinoma patients. To date, endogenous substrates for this enzyme, as well as the three-dimensional structure of human HINT2, are unknown. In this study, human HINT2 was cloned, overexpressed in Escherichia coli and purified. Crystallization was performed at 278 K using PEG 4000 as the main precipitant; the crystals, which belonged to the tetragonal space group P41212 with unit-cell parameters a = b = 76.38, c = 133.25 Å, diffracted to 2.83 Å resolution. Assuming two molecules in the asymmetric unit, the Matthews coefficient and the solvent content were calculated to be 2.63 Å(3) Da(-1) and 53.27%, respectively.

  3. Fiscal Year 2013 Budget Briefing

    NASA Image and Video Library

    2012-02-13

    NASA Chief Financial Officer Elizabeth Robinson delivers an overview briefing on NASA's fiscal year 2013 budget, Monday, Feb. 13, 2012 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  4. The Job Outlook in Brief.

    ERIC Educational Resources Information Center

    Nardone, Tom

    1984-01-01

    Describes factors affecting employment in various occupational categories and presents the "Job Outlook in Brief," a 16-page listing of changes in employment, 1982-1995, as well as employment prospects, arranged by occupational clusters. (SK)

  5. Fiscal Year 2012 Budget Briefing

    NASA Image and Video Library

    2011-02-14

    NASA Administrator Charles Bolden listens to a reporter's question come in via phone during an overview briefing on NASA's fiscal year 2012 budget, Monday, Feb. 14, 2011 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  6. Fiscal Year 2013 Budget Briefing

    NASA Image and Video Library

    2012-02-13

    NASA Administrator Charles Bolden listens as NASA Chief Financial Officer Elizabeth Robinson delivers an overview briefing on NASA's fiscal year 2013 budget, Monday, Feb. 13, 2012 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  7. Fiscal Year 2013 Budget Briefing

    NASA Image and Video Library

    2012-02-13

    NASA Administrator Charles Bolden, center, is seen during an overview briefing on NASA's fiscal year 2013 budget, Monday, Feb. 13, 2012 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  8. The Job Outlook in Brief.

    ERIC Educational Resources Information Center

    Nardone, Tom

    1984-01-01

    Describes factors affecting employment in various occupational categories and presents the "Job Outlook in Brief," a 16-page listing of changes in employment, 1982-1995, as well as employment prospects, arranged by occupational clusters. (SK)

  9. Voyager Saturn encounter press briefing

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The briefing reviewed the mission planning of the Voyager project. The near encounter trajectories of both Voyager spacecraft were examined. The Saturn system is discussed with particular emphasis on Saturn's moons.

  10. Fiscal Year 2012 Budget Briefing

    NASA Image and Video Library

    2011-02-14

    NASA Administrator Charles Bolden responds to a reporter's question during an overview briefing on NASA's fiscal year 2012 budget, Monday, Feb. 14, 2011 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  11. Fiscal Year 2013 Budget Briefing

    NASA Image and Video Library

    2012-02-13

    NASA Administrator Charles Bolden responds to a reporter's question during an overview briefing on NASA's fiscal year 2013 budget, Monday, Feb. 13, 2012 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  12. Fiscal Year 2012 Budget Briefing

    NASA Image and Video Library

    2011-02-14

    NASA Administrator Charles Bolden listens to a reporter's question during an overview briefing on NASA's fiscal year 2012 budget, Monday, Feb. 14, 2011 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  13. Fiscal Year 2012 Budget Briefing

    NASA Image and Video Library

    2011-02-14

    NASA Deputy Associate Administrator for the Office of Communications Bob Jacobs moderates the NASA Fiscal Year 2012 Budget Briefing, Monday, Feb. 14, 2011 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  14. The σ1 Receptor Engages the Redox-Regulated HINT1 Protein to Bring Opioid Analgesia Under NMDA Receptor Negative Control

    PubMed Central

    Rodríguez-Muñoz, María; Sánchez-Blázquez, Pilar; Herrero-Labrador, Raquel; Martínez-Murillo, Ricardo; Merlos, Manuel; Vela, José Miguel

    2015-01-01

    Abstract Aims: The in vivo pharmacology of the sigma 1 receptor (σ1R) is certainly complex; however, σ1R antagonists are of therapeutic interest, because they enhance mu-opioid receptor (MOR)-mediated antinociception and reduce neuropathic pain. Thus, we investigated whether the σ1R is involved in the negative control that glutamate N-methyl-d-aspartate acid receptors (NMDARs) exert on opioid antinociception. Results: The MOR C terminus carries the histidine triad nucleotide-binding protein 1 (HINT1) coupled to the regulator of G-protein signaling RGSZ2-neural nitric oxide synthase assembly. Activated MORs stimulate the production of nitric oxide (NO), and the redox zinc switch RGSZ2 converts this signal into free zinc ions that are required to recruit the redox sensor PKCγ to HINT1 proteins. Then, PKCγ impairs HINT1-RGSZ2 association and enables σ1R-NR1 interaction with MOR-HINT1 complexes to restrain opioid signaling. The inhibition of NOS or the absence of σ1Rs prevents HINT1-PKCγ interaction, and MOR-NMDAR cross-regulation fails. The σ1R antagonists transitorily remove the binding of σ1Rs to NR1 subunits, facilitate the entrance of negative regulators of NMDARs, likely Ca2+-CaM, and prevent NR1 interaction with HINT1, thereby impairing the negative feedback of glutamate on opioid analgesia. Innovation: A redox-regulated process situates MOR signaling under NMDAR control, and in this context, the σ1R binds to the cytosolic C terminal region of the NMDAR NR1 subunit. Conclusion: The σ1R antagonists enhance opioid analgesia in naïve mice by releasing MORs from the negative influence of NMDARs, and they also reset antinociception in morphine tolerant animals. Moreover, σ1R antagonists alleviate neuropathic pain, probably by driving the inhibition of up-regulated NMDARs. Antioxid. Redox Signal. 22, 799–818. PMID:25557043

  15. Neuroophthalmology: a brief Vademecum.

    PubMed

    Schwarz, Urs

    2004-01-01

    The stunning, intricate interaction between the visual, vestibular and optomotor systems--each a miracle on its own--ensures maintenance of orientation in space as well as visual recognition and target selection despite a host of sensory conflicts and adversary disturbances. Their main goals are to keep a target of interest on the fovea by either maintaining or shifting the direction of gaze in order to produce an accurate internal representation of the visual surroundings, in particular the selected target, and to continuously mirror the spatial relationship between these various visual elements and the self. Not surprising, the implementation of this host of elaborate neural networks encompasses almost every part of the brain, including the brainstem, cerebellum, extrapyramidal system and many areas of the cerebral cortex. Thus far, these systems are among the best investigated in brain research; and enormous knowledge was amassed over the last century employing a variety of techniques, including single cell recordings, eye movement studies, functional imaging and neuropsychological observations. In addition, this prolific line of research has enlightened many fundamental principles of neural and neuronal processing, which have subsequently enriched other fields of brain research as well as computational neuroscience, e.g. the discovery of receptive fields, which have now become a ubiquitous concept in many other areas of neurophysiology. This (improperly) brief, fractional and undoubtedly biased Vademecum is meant to accompany the reader into this marvellous field of neurophysiology and neurology. In particular, it stresses the clinical application of its functional neuroanatomy at the bedside, which, in many respects, is superior to other means of investigating a patient.

  16. [Widened forwarding total laryngectomy ("squared laryngectomy"). Hints of surgical techniques and personal experience].

    PubMed

    Croce, A; Moretti, A; Bianchedi, M; Neri, G; Falcone, G

    1995-10-01

    Primitive T4 laryngeal neoplasms with anterior invasion and neoplasm recurring after partial and subtotal intervention often invade the soft prelaryngeal tissues and in these cases the neoplastic illness can be no longer be controlled be "organ surgery". The widened forwarding total laryngectomy, "squared" or "carrè" laryngectomy according to some Authors of French School, is a surgical procedure not "on an organ" but "in an area" or "region" which proposes to delete, in one step, the larynx, the bone hyoid, the fasciae and the prelaryngeal muscles, the thyroid gland and, if necessary, a more or less large quantity of anterior cervical skin. If the removal involves a vast cutaneous area, it is necessary to mend the loss of substance by wrapping around a miocutaneous flap of pectoralis mayor muscle. In the last five years, 4 male patients, between 48 and 73 years, were treated with widened forwarding total laryngectomy. They were all carriers of epidermoid laryngeal carcinomas with various degrees of differentation: primitive in one patients, recidivist after performance of partial (cordectomy) and subtotal (two Labayle) surgery in the other three patients. In the only case of T4 primitive laryngeal neoplasm it was necessary to carry out a functional neck dissection bilaterally. Loss of substance always required the use of a miocutaneous flap of pectoralis mayor muscle except in one patient in which the removal of the prelaryngeal tissues was limited and therefore it was possible to make a direct seam. We always completely removed the thyroid gland, the prelaryngeal muscular system and skin of the preceding stomy (in the Labayle) sparing, on the other hand, the hyoid bone. Only one patient, who died due to recurrence a year after surgery, underwent complemental percutaneous radiotherapy. At present, three patients are alive and NED: one after 5 years, the others are in excellent conditions although the follow-up is still brief. According to our experience, we can

  17. Spanish Language Briefs for Parents, 1995.

    ERIC Educational Resources Information Center

    ERIC Clearinghouse on Rural Education and Small Schools, Charleston, WV.

    This packet contains six briefs developed specifically for Spanish-speaking parents of Mexican origin, and English translations of the briefs. In plain language, these briefs state what researchers and practitioners have learned about various ways parents can help their children do well in school. Titles of the briefs are (1) "Apoyando el…

  18. 29 CFR 2700.75 - Briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Briefs. 2700.75 Section 2700.75 Labor Regulations Relating... Commission § 2700.75 Briefs. (a) Time to file—(1) Opening and response briefs. Within 30 days after the Commission grants a petition for discretionary review, the petitioner shall file his opening brief. If the...

  19. 21 CFR 17.43 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Posthearing briefs. 17.43 Section 17.43 Food and... PENALTIES HEARINGS § 17.43 Posthearing briefs. Any party may file a posthearing brief. The presiding officer shall fix the time for filing such briefs (which shall be filed simultaneously), which shall not exceed...

  20. 43 CFR 4.1273 - Briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Briefs. 4.1273 Section 4.1273 Public Lands... Administrative Law Judges § 4.1273 Briefs. (a) Unless the Board orders otherwise, an appellant's brief is due on... appellant fails to file a timely brief, an appeal under this part may be subject to summary dismissal. (c...

  1. 24 CFR 1720.610 - Answering brief.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Answering brief. 1720.610 Section... Proceedings Appeals § 1720.610 Answering brief. Within 20 days after service of an appeal brief upon a party, such party may file an answering brief conforming to the requirements of § 1720.620. ...

  2. 17 CFR 171.26 - Answering brief.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Answering brief. 171.26... Denial and Registration Actions § 171.26 Answering brief. (a) Time for filing answering brief. Within thirty days after service of the apeal brief, the National Futures Association shall file with the...

  3. 45 CFR 150.451 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Posthearing briefs. 150.451 Section 150.451 Public... ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.451 Posthearing briefs... posthearing brief. The ALJ will establish the schedule by which such briefs must be filed. The ALJ may direct...

  4. 20 CFR 802.213 - Reply briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Reply briefs. 802.213 Section 802.213... Procedures Initial Processing § 802.213 Reply briefs. (a) Within 20 days after the receipt of a brief... upon whom it was served may file a brief, memorandum, or other statement in reply to it. (b) Arguments...

  5. 37 CFR 41.71 - Rebuttal brief.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Rebuttal brief. 41.71 Section... Rebuttal brief. (a) Within one month of the examiner's answer, any appellant may once file a rebuttal brief. (b)(1) The rebuttal brief of the owner may be directed to the examiner's answer and/or any respondent...

  6. Brief Articles for Latino Parents, 1999 Edition.

    ERIC Educational Resources Information Center

    ERIC Clearinghouse on Rural Education and Small Schools, Charleston, WV.

    This packet contains six briefs developed specifically for Spanish-speaking Latino parents, and English translations of the briefs. These briefs state what researchers and practitioners have learned about various ways parents can help their children do well in school. Earlier editions of brief articles for parents have been used in various ways by…

  7. Helpful Hints for School Emergency Management: The National Incident Management System (NIMS) and Schools. Frequently Asked Questions and FY 2006 NIMS Compliance Activities for Schools

    ERIC Educational Resources Information Center

    US Department of Education, 2006

    2006-01-01

    "Helpful Hints" offers a quick overview of school emergency preparedness topics that are frequently the subject of inquiries. The National Incident Management System (NIMS) is a comprehensive system that improves tribal and local emergency response operations through the use of the Incident Command System (ICS) and the application of standardized…

  8. Forensic Psychiatry, A Brief Introduction.

    DTIC Science & Technology

    1985-01-01

    RD-A151 971 FORENSIC PSYCHIATRY A BRIEF INTRODUCTION(U) NAVAL 1/1 JUSTICE SCHOOL NEWIPORT R I JAN 85 D95UNCLA-lSSIFIEDjF654 N mmmhhm7hh MENOMONEEmhh...L. Q28 125 * 13.211111 M 111 2.2_ IIJfL25 111__V MICROCOPY’ RESOLUTION TEST CHART NATIONAL HRFAII Of .TANDARO, l6’ NA FORENSIC PSYCHIATRY A BRIEF...any discernible 0 3 problems with nervous system. Many and varied. I. Psychological tests - Designed to isolate the abnormal by ccparison to others

  9. Some Brief Essays on Mind

    DTIC Science & Technology

    1989-07-01

    8217F11I FHFW 00 00 Some Brief Essays on Mind I- Don Perlis Technical Report 302 July 1989 DTIC ELECTE00T.3119IM UNIVERSITY OFROCHESPE~R COMPUTER...SCIENCE --. m-, 89 10 30 231 SOME BRIEF ESSAYS ON MIND Don Perlis Technical Report 302 July 1989 This work was supported in part by the Defense Advanced...SUPPLEMENTARY NOTES none 19. KEY WORDS (Continue on revrerse side if necessaaa and Iden.If" by block number) mind -body problem, intentionality, default

  10. GOES-R Science Briefing

    NASA Image and Video Library

    2016-11-17

    In the Kennedy Space Center's Press Site auditorium, members of the media participate in a mission briefing on the Geostationary Operational Environmental Satellite (GOES-R). Briefing participants included Steven Goodman, NOAA's GOES-R program scientist, and Joseph A. Pica, director of the National Weather Service Office of Observations. GOES-R is the first satellite in a series of next-generation GOES satellites for NOAA, the National Oceanographic and Atmospheric Administration. It will launch to a geostationary orbit over the western hemisphere to provide images of storms and help meteorologists predict severe weather conditionals and develop long-range forecasts.

  11. Brief Psychotherapy in Family Practice

    PubMed Central

    MacDonald, Peter J.; Brown, Alan

    1986-01-01

    A large number of patients with psychosocial or psychiatric disorders present to family physicians, and the family physician needs a model of psychotherapy with which to cope with their problems. A model of brief psychotherapy is presented which is time limited, goal directed and easy to learn. It consists of four facets drawn from established areas of psychotherapy: characteristics of the therapist; characteristics of the patient; Eriksonian developmental stages; and the process of therapy as described by Carkhuff. These facets fit together in a way which is useful to the family physician in managing those patient problems for which brief psychotherapy is indicated. PMID:21267176

  12. Histidine Triad Nucleotide-binding Protein 1 (HINT-1) Phosphoramidase Transforms Nucleoside 5′-O-Phosphorothioates to Nucleoside 5′-O-Phosphates*

    PubMed Central

    Ozga, Magdalena; Dolot, Rafal; Janicka, Magdalena; Kaczmarek, Renata; Krakowiak, Agnieszka

    2010-01-01

    Nucleoside 5′-O-phosphorothioates are formed in vivo as primary products of hydrolysis of oligo(nucleoside phosphorothioate)s (PS-oligos) that are applied as antisense therapeutic molecules. The biodistribution of PS-oligos and their pharmacokinetics have been widely reported, but little is known about their subsequent decay inside the organism. We suggest that the enzyme responsible for nucleoside 5′-O-monophosphorothioate ((d)NMPS) metabolism could be histidine triad nucleotide-binding protein 1 (Hint-1), a phosphoramidase belonging to the histidine triad (HIT) superfamily that is present in all forms of life. An additional, but usually ignored, activity of Hint-1 is its ability to catalyze the conversion of adenosine 5′-O-monophosphorothioate (AMPS) to 5′-O-monophosphate (AMP). By mutagenetic and biochemical studies, we defined the active site of Hint-1 and the kinetic parameters of the desulfuration reaction (P-S bond cleavage). Additionally, crystallographic analysis (resolution from 1.08 to 1.37 Å) of three engineered cysteine mutants showed the high similarity of their structures, which were not very different from the structure of WT Hint-1. Moreover, we found that not only AMPS but also other ribonucleoside and 2′-deoxyribonucleoside phosphorothioates are desulfurated by Hint-1 at the following relative rates: GMPS > AMPS > dGMPS ≥ CMPS > UMPS > dAMPS ≫ dCMPS > TMPS, and during the reaction, hydrogen sulfide, which is thought to be the third gaseous mediator, was released. PMID:20940308

  13. Beacons In Brief. P/PV In Brief. Issue 2

    ERIC Educational Resources Information Center

    Blank, Susan; Farley, Chelsea

    2004-01-01

    This second issue in P/PV's "In Brief" series focuses on the San Francisco Beacon Initiative and P/PV's recently released evaluation results. The Beacon Initiative established after-school programs in eight public schools in low-income San Francisco neighborhoods. P/PV's 36-month evaluation examined key developmental and academic outcomes.…

  14. Beacons In Brief. P/PV In Brief. Issue 2

    ERIC Educational Resources Information Center

    Blank, Susan; Farley, Chelsea

    2004-01-01

    This second issue in P/PV's "In Brief" series focuses on the San Francisco Beacon Initiative and P/PV's recently released evaluation results. The Beacon Initiative established after-school programs in eight public schools in low-income San Francisco neighborhoods. P/PV's 36-month evaluation examined key developmental and academic outcomes.…

  15. Introduction to the What Works Briefs. What Works Briefs.

    ERIC Educational Resources Information Center

    2002

    The What Works Briefs are a series of short, easy-to-read, "how-to" information packets designed to: (1) promote practices that support young children's social and emotional development and prevent challenging behaviors; (2) highlight practices, strategies, and intervention procedures that have been found to effectively prevent and address…

  16. Humans and Robots. Educational Brief.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This brief discusses human movement and robotic human movement simulators. The activity for students in grades 5-12 provides a history of robotic movement and includes making an End Effector for the robotic arms used on the Space Shuttle and the International Space Station (ISS). (MVL)

  17. Policy Brief: The Four Horsemen

    ERIC Educational Resources Information Center

    Hickrod, G. Alan

    2006-01-01

    In this policy brief, the author contends that there are four other principal causes of the collective poor showing on reaching state equity goals in the United States. These are the Four Horsemen of the Apocalypse in the school finance world. The first horseman rides an economic horse, the second a sociological horse, the third a political horse,…

  18. Policy Brief: The Four Horsemen

    ERIC Educational Resources Information Center

    Hickrod, G. Alan

    2006-01-01

    In this policy brief, the author contends that there are four other principal causes of the collective poor showing on reaching state equity goals in the United States. These are the Four Horsemen of the Apocalypse in the school finance world. The first horseman rides an economic horse, the second a sociological horse, the third a political horse,…

  19. Thai Education in Brief, 1982.

    ERIC Educational Resources Information Center

    Ministry of Education, Bangkok (Thailand). Educational Planning Div.

    Presenting a broad view of education in Thailand, the booklet is arranged into 10 parts. General background information is provided in the first part. Part 2 gives a brief history of Thai education, touching upon the influences of Thai kings and the Buddhist temples. Part 3 briefly describes the legislative structures underlying Thailand's…

  20. Mt. SAC Research Briefs, 2000.

    ERIC Educational Resources Information Center

    Mt. SAC Research Briefs, 2000

    2000-01-01

    These Research Briefs examine Mt. San Antonio College District's (MSAC's) (California) enrollment trends. Over the last few years, the district has drawn a large number of students from surrounding areas; however, there are concerns as to whether this fact will remain the same as new forms of educational techniques such as distance education and…

  1. CDC 2004 Programs in Brief.

    ERIC Educational Resources Information Center

    US Department of Health and Human Services, 2004

    2004-01-01

    Grouped in 16 categories, the 2004 Programs in Brief illustrates the scope of Centers for Disease Control and Prevention (CDC) and the Agency for Toxic Substances and Disease Registry (ATSDR) activities, as well as their shared goals of safer, healthier people here and around the world. Each description includes a statement of the public health…

  2. Zero Tolerance Policies. Research Brief

    ERIC Educational Resources Information Center

    Muir, Mike

    2004-01-01

    Much of this brief comes from the ERIC Digest on Zero Tolerance Policies (ERIC #: ED451579). State legislatures and school boards are adopting a growing number of zero-tolerance polices toward weapons, guns, and violence. Zero-tolerance polices are rules intended to address specific school-safety issues. Despite the controversies that it has…

  3. Childhood Obesity. Special Reference Briefs.

    ERIC Educational Resources Information Center

    Winick, Myron

    This reference brief deals with the problem of childhood obesity and how it can lead to obesity in the adult. Eighty-four abstracts are presented of studies on the identification, prevention, and treatment of obesity in children, focusing on diet and psychological attitudes. Subjects of the studies were children ranging in age from infancy through…

  4. Brief Therapy: An Adolescent Invention.

    ERIC Educational Resources Information Center

    Riley, Shirley

    1999-01-01

    Article states that brief, effective therapy with adolescents can occur by integrating the structure of solution-focused approaches with expressive qualities of art therapy within the framework of adolescent development. The three fundamentals of successful adolescent therapy are addressed. (Author/JDM)

  5. CDC 2004 Programs in Brief.

    ERIC Educational Resources Information Center

    US Department of Health and Human Services, 2004

    2004-01-01

    Grouped in 16 categories, the 2004 Programs in Brief illustrates the scope of Centers for Disease Control and Prevention (CDC) and the Agency for Toxic Substances and Disease Registry (ATSDR) activities, as well as their shared goals of safer, healthier people here and around the world. Each description includes a statement of the public health…

  6. KIDS COUNT Data Brief, 2009

    ERIC Educational Resources Information Center

    Annie E. Casey Foundation, 2009

    2009-01-01

    This 2009 KIDS COUNT Data Brief features highlights of the enhanced, mobile-friendly Data Center; data on the 10 key indicators of child well-being for all U.S. states, the District of Columbia, and many cities, counties, and school districts; and a summary of this year's essay, which calls for improvements to the nation's ability to design and…

  7. OSTP FY 2014 Budget Briefing

    NASA Image and Video Library

    2013-04-10

    Patricia Falcone, Associate Director, National Security and International Affairs Division, White House Office of Science and Technology Policy, is seen during a Fiscal Year 2014 budget briefing held at the American Association for the Advancement of Science (AAAS) on Wednesday, April 10, 2013 in Washington. Photo Credit: (NASA/Bill Ingalls)

  8. OSTP FY 2014 Budget Briefing

    NASA Image and Video Library

    2013-04-10

    Patricia Falcone, Associate Director, National Security and International Affairs Division, White House Office of Science and Technology Policy, delivers remarks during a Fiscal Year 2014 budget briefing held at the American Association for the Advancement of Science (AAAS) on Wednesday, April 10, 2013 in Washington. Photo Credit: (NASA/Bill Ingalls)

  9. NK Cells, Tumor Cell Transition, and Tumor Progression in Solid Malignancies: New Hints for NK-Based Immunotherapy?

    PubMed

    Cantoni, Claudia; Huergo-Zapico, Leticia; Parodi, Monica; Pedrazzi, Marco; Mingari, Maria Cristina; Moretta, Alessandro; Sparatore, Bianca; Gonzalez, Segundo; Olive, Daniel; Bottino, Cristina; Castriconi, Roberta; Vitale, Massimo

    2016-01-01

    Several evidences suggest that NK cells can patrol the body and eliminate tumors in their initial phases but may hardly control established solid tumors. Multiple factors, including the transition of tumor cells towards a proinvasive/prometastatic phenotype, the immunosuppressive effect of the tumor microenvironment, and the tumor structure complexity, may account for limited NK cell efficacy. Several putative mechanisms of NK cell suppression have been defined in these last years; conversely, the cross talk between NK cells and tumor cells undergoing different transitional phases remains poorly explored. Nevertheless, recent in vitro studies and immunohistochemical analyses on tumor biopsies suggest that NK cells could not only kill tumor cells but also influence their evolution. Indeed, NK cells may induce tumor cells to change the expression of HLA-I, PD-L1, or NKG2D-L and modulate their susceptibility to the immune response. Moreover, NK cells may be preferentially located in the borders of tumor masses, where, indeed, tumor cells can undergo Epithelial-to-Mesenchymal Transition (EMT) acquiring prometastatic phenotype. Finally, the recently highlighted role of HMGB1 both in EMT and in amplifying the recruitment of NK cells provides further hints on a possible effect of NK cells on tumor progression and fosters new studies on this issue.

  10. Maximum Time-to-Rescue After the 1908 Messina-Reggio Calabria Earthquake was 20 Days: Hints for Disaster Planning?

    PubMed

    De Santo, Natale Gaspare; Bisaccia, Carmela; De Santo, Luca Salvatore

    2017-06-01

    Introduction Maximum time-to-rescue has been studied accurately for many earthquakes in the years 1985-2004. No study is available for historical quakes. Hypothesis/Problem This study aimed to evaluate long-term survivors (from the fifth day after the quake) of the Messina-Reggio Calabria earthquake (1908; Italy), which is considered, historically, to be the worst seismic event in Europe. Accurate readings of 11 national newspapers from the fifth day after the quake looking for rescued persons and transferring, to an ad hoc form, all data relating to each rescued person. The maximum time-to rescue was 20 days. There were 225 survivors, among them 51 children (22.6 %). For 23 out 225 rescued persons, there was evidence of availability of foods and drinkable fluids while under the rubble. The maximum time-to-rescue under the debris following this historical earthquake far exceeds that of all other quakes that occurred in the years 1985-2004. The long survival under debris was probably due to the lack of an order to stop search and rescue. Recent strategies reducing the time for search and rescue carry the risk of missing survivors. De Santo NG , Bisaccia C , De Santo LS . Maximum time-to-rescue after the 1908 Messina-Reggio Calabria Earthquake was 20 days: hints for disaster planning? Prehosp Disaster Med. 2017;32(3):249-252.

  11. Smokers who use internet and smokers who don't: data from the Health Information and National Trends Survey (HINTS).

    PubMed

    Stoddard, Jacqueline L; Augustson, Erik M

    2006-12-01

    Web-assisted tobacco interventions (WATI) have proliferated in recent years, but little is known about those such sites are reaching and those who might be reached in the future. A better understanding of factors that differentiate smokers who do and do not use the Internet could help developers of smoking cessation resources optimize the content and dissemination of resources to these two groups. Using the 2003 Health Information National Trends Survey (HINTS), a nationally representative survey of U.S. adults, we compared smokers using the Internet (n=728) with smokers not using the Internet (n=516) on demographics, smoking history, healthcare (status, care, access, and use), beliefs about lung cancer risks, and media preferences. Our results showed that compared with smokers not on the Internet, those using the Internet had a higher income and were more likely to be employed, despite having a younger age. Internet-connected smokers also reported less psychological distress, fewer barriers to healthcare, and a greater interest in quitting smoking. Preferences for media also differed by Internet status: Those on the Internet spent less time on television and more time with newspapers and magazines than those not on the Internet. These and other differences may assist the public health community with both the design and dissemination of resources to help smokers quit.

  12. NK Cells, Tumor Cell Transition, and Tumor Progression in Solid Malignancies: New Hints for NK-Based Immunotherapy?

    PubMed Central

    Huergo-Zapico, Leticia; Parodi, Monica; Pedrazzi, Marco; Mingari, Maria Cristina; Sparatore, Bianca; Gonzalez, Segundo; Olive, Daniel; Bottino, Cristina

    2016-01-01

    Several evidences suggest that NK cells can patrol the body and eliminate tumors in their initial phases but may hardly control established solid tumors. Multiple factors, including the transition of tumor cells towards a proinvasive/prometastatic phenotype, the immunosuppressive effect of the tumor microenvironment, and the tumor structure complexity, may account for limited NK cell efficacy. Several putative mechanisms of NK cell suppression have been defined in these last years; conversely, the cross talk between NK cells and tumor cells undergoing different transitional phases remains poorly explored. Nevertheless, recent in vitro studies and immunohistochemical analyses on tumor biopsies suggest that NK cells could not only kill tumor cells but also influence their evolution. Indeed, NK cells may induce tumor cells to change the expression of HLA-I, PD-L1, or NKG2D-L and modulate their susceptibility to the immune response. Moreover, NK cells may be preferentially located in the borders of tumor masses, where, indeed, tumor cells can undergo Epithelial-to-Mesenchymal Transition (EMT) acquiring prometastatic phenotype. Finally, the recently highlighted role of HMGB1 both in EMT and in amplifying the recruitment of NK cells provides further hints on a possible effect of NK cells on tumor progression and fosters new studies on this issue. PMID:27294158

  13. Racial and ethnic differences in direct-to-consumer genetic tests awareness in HINTS 2007: sociodemographic and numeracy correlates.

    PubMed

    Langford, Aisha T; Resnicow, Ken; Roberts, J Scott; Zikmund-Fisher, Brian J

    2012-06-01

    To examine the association of 1) race/ethnicity and 2) numeracy with awareness of DTC genetic tests. Secondary analysis of 6,754 Hispanic, black, and white adult respondents to the National Cancer Institute's 2007 Health Information National Trends Survey (HINTS). Logistic regression was used to examine sociodemographic predictors of DTC genetic tests awareness including race/ethnicity, income, education, and gender. Next, two numeracy variables were added to the model. After controlling for sociodemographic variables, black respondents were significantly less likely to have heard of DTC genetic tests compared to white respondents (OR = 0.79; CI: 0.65-0.97). When numeracy variables were added to the model, the effect of black race was no longer significant (OR = 0.84; CI: 0.69-1.04). Hispanic respondents did not significantly differ from white respondents in awareness of DTC genetic tests. Other significant correlates of DTC genetic tests awareness in the full model included education, income, age, and numeracy variables including degree to which people use medical statistics and numbers to make health decisions, and preference for words or numbers when discussing "the chance of something happening." Although black respondents were generally less aware of DTC genetic tests than white respondents, this relationship appears to be partially mediated by numeracy.

  14. Earnings in e-learning: knowledge, CME credits or both? Hints from analysis of attendance dynamics and users' behaviour.

    PubMed

    Mazzoleni, M Cristina; Rognoni, Carla; Finozzi, Enrico; Landro, Mauro; Capodaglio, Edda; Imbriani, Marcello; Giorgi, Ines

    2010-01-01

    Many papers report and convey positive opinion about the use of e-learning in the healthcare sector. The issue is how to exploit at best such a powerful instrument. Starting from data regarding the usage of a CME e-learning course, attendance dynamics and users' behaviour have been inspected with the aim of getting some hints about how to improve the development and the delivery of e-learning courses for CME, and to promote knowledge acquisition at best. The different paths followed by 7811 users have been modeled, from enrolment to conclusion/drop-out, then the behaviour in terms of effort, elapsed time, achieved result have been analyzed. The obtained results point out: good acceptance (retention rate 83%) of a not basic educational model and effectiveness (success rate 79%). At the same time the inspection of behaviour has shown that there is a good margin of possible improvement in terms of knowledge acquisition. Conclusions provide a list of issues to keep in mind during system development, in order to provide CME e-learning meeting both credit and knowledge acquisition goals.

  15. Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif

    PubMed Central

    Bürglin, Thomas R

    2008-01-01

    Background The Hedgehog (Hh) signaling pathway plays important roles in human and animal development as well as in carcinogenesis. Hh molecules have been found in both protostomes and deuterostomes, but curiously the nematode Caenorhabditis elegans lacks a bona-fide Hh. Instead a series of Hh-related proteins are found, which share the Hint/Hog domain with Hh, but have distinct N-termini. Results We performed extensive genome searches such as the cnidarian Nematostella vectensis and several nematodes to gain further insights into Hh evolution. We found six genes in N. vectensis with a relationship to Hh: two Hh genes, one gene with a Hh N-terminal domain fused to a Willebrand factor type A domain (VWA), and three genes containing Hint/Hog domains with distinct novel N-termini. In the nematode Brugia malayi we find the same types of hh-related genes as in C. elegans. In the more distantly related Enoplea nematodes Xiphinema and Trichinella spiralis we find a bona-fide Hh. In addition, T. spiralis also has a quahog gene like C. elegans, and there are several additional hh-related genes, some of which have secreted N-terminal domains of only 15 to 25 residues. Examination of other Hh pathway components revealed that T. spiralis - like C. elegans - lacks some of these components. Extending our search to all eukaryotes, we recovered genes containing a Hog domain similar to Hh from many different groups of protists. In addition, we identified a novel Hint gene family present in many eukaryote groups that encodes a VWA domain fused to a distinct Hint domain we call Vint. Further members of a poorly characterized Hint family were also retrieved from bacteria. Conclusion In Cnidaria and nematodes the evolution of hh genes occurred in parallel to the evolution of other genes that contain a Hog domain but have different N-termini. The fact that Hog genes comprising a secreted N-terminus and a Hog domain are found in many protists indicates that this gene family must have

  16. 37 CFR 41.68 - Respondent's brief.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Respondent's brief. 41.68... Respondent's brief. (a)(1) Respondent(s) in an appeal may once, within the time limit for filing set forth in... title. (2) The brief must be signed by the party, or the party's duly authorized attorney or agent, and...

  17. 37 CFR 41.67 - Appellant's brief.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Appellant's brief. 41.67... Appellant's brief. (a)(1) Appellant(s) may once, within time limits for filing set forth in § 41.66, file a... title. (2) The brief must be signed by the appellant, or the appellant's duly authorized attorney or...

  18. 39 CFR 955.24 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Posthearing briefs. 955.24 Section 955.24 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE BEFORE THE POSTAL SERVICE BOARD OF CONTRACT APPEALS § 955.24 Posthearing briefs. Posthearing briefs may be submitted upon such terms as may be...

  19. 49 CFR 1113.18 - Briefs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... be required, and reply briefs will not normally be permitted. (b) Evidence abstract. A brief filed after a hearing may contain an abstract of the evidence relied upon by the party filing it, preferably... appears. In the event the party elects not to include a separate abstract in his brief, he should give...

  20. 49 CFR 1113.18 - Briefs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... be required, and reply briefs will not normally be permitted. (b) Evidence abstract. A brief filed after a hearing may contain an abstract of the evidence relied upon by the party filing it, preferably... appears. In the event the party elects not to include a separate abstract in his brief, he should give...

  1. 49 CFR 1113.18 - Briefs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... be required, and reply briefs will not normally be permitted. (b) Evidence abstract. A brief filed after a hearing may contain an abstract of the evidence relied upon by the party filing it, preferably... appears. In the event the party elects not to include a separate abstract in his brief, he should give...

  2. 49 CFR 1113.18 - Briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... be required, and reply briefs will not normally be permitted. (b) Evidence abstract. A brief filed after a hearing may contain an abstract of the evidence relied upon by the party filing it, preferably... appears. In the event the party elects not to include a separate abstract in his brief, he should give...

  3. 49 CFR 1113.18 - Briefs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... be required, and reply briefs will not normally be permitted. (b) Evidence abstract. A brief filed after a hearing may contain an abstract of the evidence relied upon by the party filing it, preferably... appears. In the event the party elects not to include a separate abstract in his brief, he should give...

  4. 45 CFR 213.31 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Posthearing briefs. 213.31 Section 213.31 Public..., Decisions § 213.31 Posthearing briefs. The presiding officer shall fix the time for filing posthearings briefs, which may contain proposed findings of fact and conclusions of law, and, if permitted, reply...

  5. 24 CFR 26.48 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Posthearing briefs. 26.48 Section 26.48 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... Posthearing briefs. Posthearing briefs shall be filed only upon order by the ALJ. ...

  6. 41 CFR 50-203.9 - Briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Briefs. 50-203.9 Section...-Healey Public Contracts Act § 50-203.9 Briefs. (a) Any interested person or organization shall be entitled to file with the administrative law judge, Department of Labor, Washington, D.C., briefs, proposed...

  7. 17 CFR 9.22 - Appeal brief.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Appeal brief. 9.22 Section 9... Appeals § 9.22 Appeal brief. (a) Time to file. Any person who has filed a notice of appeal in accordance with the provisions of § 9.20 must perfect the appeal by filing an appeal brief with the Proceedings...

  8. 43 CFR 4.110 - Prehearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Prehearing briefs. 4.110 Section 4.110... Prehearing briefs. Based on an examination of the appeal file, the pleadings, and a determination of whether..., in its discretion, require the parties to submit prehearing briefs in any case in which a hearing has...

  9. 46 CFR 202.7 - Supplemental briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Supplemental briefs. 202.7 Section 202.7 Shipping... REVIEW BY SECRETARY OF TRANSPORTATION OF ACTIONS BY MARITIME SUBSIDY BOARD § 202.7 Supplemental briefs. If an order taking review is entered by the Secretary, further briefs supplementing the arguments set...

  10. 37 CFR 41.41 - Reply brief.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Reply brief. 41.41 Section 41... COMMERCE PRACTICE BEFORE THE BOARD OF PATENT APPEALS AND INTERFERENCES Ex Parte Appeals § 41.41 Reply brief... file a reply brief to an examiner's answer within two months from the date of the examiner's answer. (2...

  11. 42 CFR 430.100 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Posthearing briefs. 430.100 Section 430.100 Public... State Medicaid Plans and Practice to Federal Requirements § 430.100 Posthearing briefs. The presiding officer fixes the time for filing posthearing briefs, which may contain proposed findings of fact and...

  12. 20 CFR 802.215 - Additional briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Additional briefs. 802.215 Section 802.215 Employees' Benefits BENEFITS REVIEW BOARD, DEPARTMENT OF LABOR RULES OF PRACTICE AND PROCEDURE Prereview Procedures Initial Processing § 802.215 Additional briefs. Additional briefs may be filed or ordered in the...

  13. 16 CFR 1025.22 - Prehearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Prehearing briefs. 1025.22 Section 1025.22... Prehearing briefs. Not later than ten (10) days prior to the hearing, unless otherwise ordered by the Presiding Officer, the parties may simultaneously serve and file prehearing briefs which should set forth...

  14. 25 CFR 17.9 - Briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Briefs. 17.9 Section 17.9 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROBATE ACTION ON WILLS OF OSAGE INDIANS § 17.9 Briefs. When there are... to file a brief or other statement of his contentions, showing service on opposing counsel or...

  15. 5 CFR 2423.33 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Posthearing briefs. 2423.33 Section 2423....33 Posthearing briefs. Except when bench decisions are issued pursuant to § 2423.31(d), posthearing briefs may be filed with the Administrative Law Judge within a time period set by the Judge, not to...

  16. 36 CFR 1150.71 - Briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Briefs. 1150.71 Section 1150... PRACTICE AND PROCEDURES FOR COMPLIANCE HEARINGS Hearing Procedures § 1150.71 Briefs. The judge may require... also require the parties to submit trial briefs. ...

  17. 17 CFR 171.25 - Appeal brief.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Appeal brief. 171.25 Section... Denial and Registration Actions § 171.25 Appeal brief. (a) Time to file. Any person who has filed a... appeal brief with the Proceedings Clerk within thirty days after service of the record by the National...

  18. 45 CFR 1386.110 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Posthearing briefs. 1386.110 Section 1386.110... Posthearing Procedures, Decisions § 1386.110 Posthearing briefs. The presiding officer must fix the time for filing posthearing briefs. This time may not exceed 30 days after termination of the hearing and receipt...

  19. 49 CFR 511.22 - Prehearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Prehearing briefs. 511.22 Section 511.22...; Interlocutory Appeals; Summary Judgment; Settlement § 511.22 Prehearing briefs. Not later ten (10) days prior to... circumstances, simultaneously serve and file prehearing briefs, which shall set forth (a) a statement of the...

  20. CSA/ASC Press Briefing

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Nicole Gignac, Senior Communications Advisor Canadian Space Agency (CSA), introduces the panel for this CSA/ASC press briefing. The panel consist of: Dr. Steve Maclean, CSA astronaut; Dr. Paul Cooper, Deputy General Manager, MacDonald, Dettwiler and Associates Ltd. (MDA); and Dr. Iain Christie, Director of Research and Development from NEPTEC. Maclean will fly on the STS-115 Mission in February of 2006. He presents pictures and talks about the crewmembers of the Space Shuttle Columbia and Space Shuttle Discovery. Maclean also discusses entry risks as it pertains to the leading edge wing of Discovery. Paul Cooper explains and shows a video presentation of Canadarm robotics. The briefing ends with Dr Christie explaining the sensitive three dimensional inspections are performed in space that looks for cracks in the leading edge wing of the Space Shuttle Discovery.

  1. STS-93/ Chandra Science Briefing

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This video shows a press briefing, reviewing the type of information which scientist hope to get from the Chandra X-ray Telescope. The telescope is scheduled to be launched during the STS-93 flight. The participants in the briefing are: Don Savage, of NASA Headquarters; Ed Weiler, Associate Administrator for Space Sciences; Alan Bunner, Chandra Project Scientist and Michael Turner, an astrophysicist at the University of Chicago. After the introduction by Mr. Savage, the broad scientific goals of the Chandra mission are reviewed by Dr. Weiler. This is followed by an acknowledgement of many of the people who participated in the development of the Chandra Telescope. This is followed by a discussion of the astrophysics and the information which the telescope should provide. Mrs. Chandrasekhar, the widow of Subrahmanyan Chandrasekhar, was in the audience. She was introduced and spoke briefly about the late Nobel Laureate astrophysicist.

  2. GOES-R Science Briefing

    NASA Image and Video Library

    2016-11-17

    In the Kennedy Space Center's Press Site auditorium, members of the media participate in a mission briefing on the Geostationary Operational Environmental Satellite (GOES-R). Briefing participants from left are: Steven Goodman, NOAA's GOES-R program scientist; Joseph A. Pica, director of the National Weather Service Office of Observations; Sandra Cauffman, deputy director of NASA's Earth Science Division; and Damon Penn, assistant administrator for response at the Federal Emergency Management Agency. GOES-R is the first satellite in a series of next-generation GOES satellites for NOAA, the National Oceanographic and Atmospheric Administration. It will launch to a geostationary orbit over the western hemisphere to provide images of storms and help meteorologists predict severe weather conditionals and develop long-range forecasts.

  3. GOES-R Science Briefing

    NASA Image and Video Library

    2016-11-17

    In the Kennedy Space Center's Press Site auditorium, members of the media participate in a mission briefing on the Geostationary Operational Environmental Satellite (GOES-R). Briefing participants from left are: Steven Goodman, NOAA's GOES-R program scientist; Joseph A. Pica, director of the National Weather Service Office of Observations; and Sandra Cauffman, deputy director of NASA's Earth Science Division. GOES-R is the first satellite in a series of next-generation GOES satellites for NOAA, the National Oceanographic and Atmospheric Administration. It will launch to a geostationary orbit over the western hemisphere to provide images of storms and help meteorologists predict severe weather conditionals and develop long-range forecasts.

  4. BRIEF INTERVENTIONS IN SUBSTANCE ABUSE

    PubMed Central

    Kumar, Suresh; Malhotra, Anil

    2000-01-01

    Brief interventions in substance abuse refer to a group of cost-effective and time efficient strategies that aim at reduction of substance use and/or harm related to substance use. They are grounded in the scientific principles of harm reduction stage of change, motivational interviewing and feasibility of community-level delivery. This review discusses the characteristics, elements, and techniques of brief interventions for abuse of alcohol, tobacco and other drugs. The available evidence for effectiveness of these strategies vis-a-vis no treatment or extended treatment is also reviewed, which clearly supports these interventions to be effective, especially for alcohol abuse but also for others It is argued that India presents a fertile ground for application of these strategies and that Indian research in this area should be a top priority. PMID:21407932

  5. GOES-R Science Briefing

    NASA Image and Video Library

    2016-11-17

    In the Kennedy Space Center's Press Site auditorium, members of the media participate in a mission briefing on the Geostationary Operational Environmental Satellite (GOES-R). Briefing participants from left are: Sean Potter of NASA Communications; Steven Goodman, NOAA's GOES-R program scientist; Joseph A. Pica, director of the National Weather Service Office of Observations; Sandra Cauffman, deputy director of NASA's Earth Science Division; and Damon Penn, assistant administrator for response at the Federal Emergency Management Agency. GOES-R is the first satellite in a series of next-generation GOES satellites for NOAA, the National Oceanographic and Atmospheric Administration. It will launch to a geostationary orbit over the western hemisphere to provide images of storms and help meteorologists predict severe weather conditionals and develop long-range forecasts.

  6. OCO-2 Post Launch Briefing

    NASA Image and Video Library

    2014-07-02

    Geoff Yoder, deputy associate administrator for programs, Science Mission Directorate, NASA Headquarters, discusses the successful launch of the Orbiting Carbon Observatory-2 (OCO-2), NASA’s first spacecraft dedicated to studying carbon dioxide, during a press briefing, Wednesday, July 2, 2014, at the Vandenberg Air Force Base, Calif. OCO-2 will measure the global distribution of carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. Photo Credit: (NASA/Bill Ingalls)

  7. OCO-2 Post Launch Briefing

    NASA Image and Video Library

    2014-07-02

    NASA Kennedy Space Center Public Affairs Officer George Diller, moderates a post-launch press briefing, following the successful launch of the Orbiting Carbon Observatory-2 (OCO-2), NASA’s first spacecraft dedicated to studying carbon dioxide, Wednesday, July 2, 2014, at the Vandenberg Air Force Base, Calif. OCO-2 will measure the global distribution of carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. Photo Credit: (NASA/Bill Ingalls)

  8. OCO-2 Post Launch Briefing

    NASA Image and Video Library

    2014-07-02

    Mike Miller, senior vice president, Science and Environmental Satellite Programs, Orbital Sciences Space Systems Group, discusses the successful launch of the Orbiting Carbon Observatory-2 (OCO-2), NASA’s first spacecraft dedicated to studying carbon dioxide, during a press briefing, Wednesday, July 2, 2014, at the Vandenberg Air Force Base, Calif. OCO-2 will measure the global distribution of carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. Photo Credit: (NASA/Bill Ingalls)

  9. OCO-2 Post Launch Briefing

    NASA Image and Video Library

    2014-07-02

    Ralph Basilio, OCO-2 project manager, Jet Propulsion Laboratory, discusses the successful launch of the Orbiting Carbon Observatory-2 (OCO-2), NASA’s first spacecraft dedicated to studying carbon dioxide, during a press briefing, Wednesday, July 2, 2014, at the Vandenberg Air Force Base, Calif. OCO-2 will measure the global distribution of carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. Photo Credit: (NASA/Bill Ingalls)

  10. Government Program Briefing: Smart Metering

    SciTech Connect

    Doris, E.; Peterson, K.

    2011-09-01

    This document is adapted and updated from a memo delivered to the City Council of New Orleans, the office of the Mayor of New Orleans, the Chairperson of the Citizen Stakeholders Group (New Orleans Energy Task Force) and the U.S. Department of Energy (DOE) Project Officer in March 2008. This briefing piece provides an overview of the benefits, costs, and challenges of smart metering.

  11. A Brief History of Acoustics

    NASA Astrophysics Data System (ADS)

    Rossing, Thomas

    Although there are certainly some good historical treatments of acoustics in the literature, it still seems appropriate to begin a handbook of acoustics with a brief history of the subject. We begin by mentioning some important experiments that took place before the 19th century. Acoustics in the 19th century is characterized by describing the work of seven outstanding acousticians: Tyndall, von Helmholtz, Rayleigh, Stokes, Bell, Edison, and Koenig. Of course this sampling omits the mention of many other outstanding investigators.

  12. GOES-R Science Briefing

    NASA Image and Video Library

    2016-11-17

    In the Kennedy Space Center's Press Site auditorium, Sean Potter of NASA Communications, moderates a mission briefing on the Geostationary Operational Environmental Satellite (GOES-R). GOES-R is the first satellite in a series of next-generation GOES satellites for NOAA, the National Oceanographic and Atmospheric Administration. It will launch to a geostationary orbit over the western hemisphere to provide images of storms and help meteorologists predict severe weather conditionals and develop long-range forecasts.

  13. STS-34: Mission Overview Briefing

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Live footage shows Milt Heflin, the Lead Flight Director participating in the STS-34 Mission Briefing. He addresses the primary objective, and answered questions from the audience and other NASA Centers. Heflin also mentions the Shuttle Solar Backscatter Ultraviolet secondary payload, and several experiments. These experiments include Growth Hormone Crystal Distribution (Plants), Polymer Morphology, Sensor Technology Experiment, Mesoscale Lightning Experiment, Shuttle Student Involvement Program "Ice Crystals", and the Air Force Maui Optical Site.

  14. OSTP FY 2014 Budget Briefing

    NASA Image and Video Library

    2013-04-10

    Dr. John P. Holdren, Assistant to the President for Science and Technology, Director of the White House Office of Science and Technology Policy, speaks during a Fiscal Year 2014 budget briefing held with Patricia Falcone of OSTP, Charlie Bolden from NASA, Francis Collins from NIH, Cora Marrett from NSF, and Kathryn Sullivan from NOAA, at the American Association for the Advancement of Science (AAAS) on Wednesday, April 10, 2013 in Washington. Photo Credit: (NASA/Bill Ingalls)

  15. OSTP FY 2014 Budget Briefing

    NASA Image and Video Library

    2013-04-10

    Patricia Falcone, Associate Director, National Security and International Affairs Division, White House Office of Science and Technology Policy, delivers remarks during a Fiscal Year 2014 budget briefing with Dr. John P. Holdren, Director of OSTP, Charlie Bolden from NASA, Francis Collins from NIH, Cora Marrett from NSF, and Kathryn Sullivan from NOAA, at the American Association for the Advancement of Science (AAAS) on Wednesday, April 10, 2013 in Washington. Photo Credit: (NASA/Bill Ingalls)

  16. OSTP FY 2014 Budget Briefing

    NASA Image and Video Library

    2013-04-10

    NASA Administrator Charlie Bolden, delivers remarks during a White House Office of Science and Technology Policy (OSTP) Fiscal Year 2014 budget briefing held with with Dr. John P. Holdren, Director of OSTP, Patricia Falcone of OSTP, Francis Collins from NIH, Cora Marrett from NSF, and Kathryn Sullivan from NOAA, at the American Association for the Advancement of Science (AAAS) on Wednesday, April 10, 2013 in Washington. Photo Credit: (NASA/Bill Ingalls)

  17. STS-34: Mission Overview Briefing

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Live footage shows Milt Heflin, the Lead Flight Director participating in the STS-34 Mission Briefing. He addresses the primary objective, and answered questions from the audience and other NASA Centers. Heflin also mentions the Shuttle Solar Backscatter Ultraviolet secondary payload, and several experiments. These experiments include Growth Hormone Crystal Distribution (Plants), Polymer Morphology, Sensor Technology Experiment, Mesoscale Lightning Experiment, Shuttle Student Involvement Program "Ice Crystals", and the Air Force Maui Optical Site.

  18. Family history of gastric cancer correlates with decreased expression of HINT1 tumor suppressor gene in gastric mucosa of dyspeptic patients

    PubMed Central

    ZUK, KAROLINA; PECZEK, LUKASZ; STEC-MICHALSKA, KRYSTYNA; MEDREK, MARTA; NAWROT, BARBARA

    2012-01-01

    Gastric cancer (GC) is the fourth most common cancer and the second most common cause of cancer-associated mortality worldwide. Approximately 10% of gastric cancers are hereditary and a small percentage of these cases (1–3%) have been classified as a single hereditary syndrome (hereditary diffuse gastric cancer). We previously demonstrated that a family history of gastric cancer (FHGC) contributes to a predisposition towards the development of gastric cancer. Our data revealed that for dyspeptic patients whose first-degree relative(s) succumbed to GC, the levels of the fragile histidine triad pro-apoptotic protein in gastric mucosa were decreased. Another member of the histidine triad protein superfamily is histidine triad nucleotide-binding protein 1 (HINT1), a novel tumor suppressor that plays an inhibitory role in the control of gene transcription. The study comprised 38 ethnically homogeneous patients with dyspeptic symptoms without concomitant chronic diseases (18 controls/20 patients with FHGC). The results showed that the samples from the control patients predominantly exhibited non-atrophic changes (approximately 90%), whereas atrophic changes occurred more frequently in patients with FHGC. Notably, the expression levels of the HINT1 gene were markedly higher in the samples with atrophy taken from the antrum of FHGC patients compared to the non-atrophic samples. Moreover, the levels of HINT1 mRNA in samples obtained from the antrum of patients with FHGC were lower compared to analogous samples from the control individuals. The decreased levels of HINT1 mRNA in the antrum samples of patients with the FHGC indicate that it is a factor predisposing those patients to the development of gastric cancer. PMID:22740884

  19. Overcoming students' misconceptions concerning thermal physics with the aid of hints and peer interaction during a lecture course

    NASA Astrophysics Data System (ADS)

    Leinonen, Risto; Asikainen, Mervi A.; Hirvonen, Pekka E.

    2013-12-01

    As has been shown by previous research, students may possess various misconceptions in the area of thermal physics. In order to help them overcome misconceptions observed prior to instruction, we implemented a one-hour lecture-based intervention in their introductory thermal physics course. The intervention was held after the conventional lectures and homework sessions, and it consisted of three phases: individual working, hinting, and peer discussion. To probe students’ conceptual understanding before, during, and after the intervention, use was made of a diagnostic test related to the multiphased process of an ideal gas [D. E. Meltzer, Am. J. Phys. 72, 1432 (2004)AJPIAS0002-950510.1119/1.1789161]. The students’ conceptions were monitored by analyzing the explanations they provided and by recording the peer discussions of five voluntary pairs. The intervention helped students to realize the flaws in their explanations and increased the proportion of their scientific explanations, the increase being statistically significant in five tasks out of seven. When the same themes were addressed in a post-test, it was shown that the level of accurate explanations remained almost constant after the intervention, and hence it could be deduced that the impact had not been short-lived. In comparison with earlier studies conducted with the same material, our intervention produced a better learning outcome, the difference being 15-20 percentage points. In addition, the number of misconceptions on the part of the students was smaller in our study, although with individual exceptions. Hence, we conclude that the intervention was successful and that similar interventions could also be designed and implemented in other areas of physics.

  20. Perturbed Lepton-Specific Two-Higgs-Doublet Model Facing Experimental Hints for Physics beyond the Standard Model.

    PubMed

    Crivellin, Andreas; Heeck, Julian; Stoffer, Peter

    2016-02-26

    BABAR, Belle, and LHCb Collaborations report evidence for new physics in B→Dτν and B→D^{*}τν of approximately 3.8σ. There is also the long lasting discrepancy of about 3σ in the anomalous magnetic moment of the muon, and the branching ratio for τ→μνν is 1.8σ (2.4σ) above the standard model expectation using the HFAG (PDG) values. Furthermore, CMS Collaboration finds hints for a nonzero decay rate of h→μτ. Interestingly, all these observations can be explained by introducing new scalars. In this Letter we consider these processes within a lepton-specific two-Higgs doublet model (i.e., of type X) with additional nonstandard Yukawa couplings. It is found that one can accommodate τ→μνν with modified Higgs-τ couplings. The anomalous magnetic moment of the muon can be explained if the additional neutral CP-even Higgs boson H is light (below 100 GeV). Also R(D) and R(D^{*}) can be easily explained by additional t-c-Higgs couplings. Combining these t-c couplings with a light H the decay rate for t→Hc can be in a testable range for the LHC. Effects in h→μτ are also possible, but in this case a simultaneous explanation of the anomalous magnetic moment of the muon is difficult due to the unavoidable τ→μγ decay.

  1. Trends in cancer survivors' experience of patient-centered communication: results from the Health Information National Trends Survey (HINTS).

    PubMed

    Blanch-Hartigan, Danielle; Chawla, Neetu; Moser, Richard P; Finney Rutten, Lila J; Hesse, Bradford W; Arora, Neeraj K

    2016-12-01

    Two Institute of Medicine reports almost a decade apart suggest that cancer survivors often feel "lost in transition" and experience suboptimal quality of care. The six core functions of patient-centered communication: managing uncertainty, responding to emotions, making decisions, fostering healing relationships, enabling self-management, and exchanging information, represent a central aspect of survivors' care experience that has not been systematically investigated. Nationally representative data from four administrations of the Health Information National Trends Survey (HINTS) was merged with combined replicate weights using the jackknife replication method. Linear and logistic regression models were used to assess (1) characteristics of cancer survivors (N = 1794) who report suboptimal patient-centered communication and (2) whether survivors' patient-centered communication experience changed from 2007 to 2013. One third to one half of survivors report suboptimal patient-centered communication, particularly on core functions of providers helping manage uncertainty (48 %) and responding to emotions (49 %). In a fully adjusted linear regression model, survivors with more education (Wald F = 2.84, p = .04), without a usual source of care (Wald F = 11.59, p < .001), and in poorer health (Wald F = 9.08, p < .001) were more likely to report less patient-centered communication. Although ratings of patient-centered communication improved over time (p trend = .04), this trend did not remain significant in fully adjusted models. Despite increased attention to survivorship, many survivors continue to report suboptimal communication with their health care providers. Survivorship communication should include managing uncertainty about future risk and address survivors' emotional needs. Efforts to improve patient-centered communication should focus on survivors without a usual source of care and in poorer health.

  2. Perturbed Lepton-Specific Two-Higgs-Doublet Model Facing Experimental Hints for Physics beyond the Standard Model

    NASA Astrophysics Data System (ADS)

    Crivellin, Andreas; Heeck, Julian; Stoffer, Peter

    2016-02-01

    BABAR, Belle, and LHCb Collaborations report evidence for new physics in B →D τ ν and B →D*τ ν of approximately 3.8 σ . There is also the long lasting discrepancy of about 3 σ in the anomalous magnetic moment of the muon, and the branching ratio for τ →μ ν ν is 1.8 σ (2.4 σ ) above the standard model expectation using the HFAG (PDG) values. Furthermore, CMS Collaboration finds hints for a nonzero decay rate of h →μ τ . Interestingly, all these observations can be explained by introducing new scalars. In this Letter we consider these processes within a lepton-specific two-Higgs doublet model (i.e., of type X) with additional nonstandard Yukawa couplings. It is found that one can accommodate τ →μ ν ν with modified Higgs-τ couplings. The anomalous magnetic moment of the muon can be explained if the additional neutral C P -even Higgs boson H is light (below 100 GeV). Also R (D ) and R (D*) can be easily explained by additional t -c -Higgs couplings. Combining these t -c couplings with a light H the decay rate for t →H c can be in a testable range for the LHC. Effects in h →μ τ are also possible, but in this case a simultaneous explanation of the anomalous magnetic moment of the muon is difficult due to the unavoidable τ →μ γ decay.

  3. Could structural similarity of specific domains between animal globins and plant antenna proteins provide hints important for the photoprotection mechanism?

    PubMed

    Ioannidis, Nikolaos E; Kotzabasis, Kiriakos

    2015-01-07

    Non photochemical quenching is a fundamental mechanism in photosynthesis, which protects plants against excess excitation energy and is of crucial importance for their survival and fitness. In the last decades hundreds of papers have appeared that describe the role of antenna regulation in protection or the so called qE response. However, the exact quenching site is still obscure. Previously overlooked features of the antenna may provide hints towards the elucidation of its functionality and of the quenching mechanism. Recently it was demonstrated that the catalytic domain of human myoglobin that binds the pigment (i.e. heme) is similar in structure to the domain of the light harvesting complex II of pea that binds Chl a 614 (former known as b3). In addition, it is well accepted that conformational changes of the chlorophyll macrocycle result in reversible changes of fluorescence (the lowest fluorescence corresponds to non planar macrocycle). Here we put forward a hypothesis regarding the molecular mechanism that leads to the formation of a quenching center inside the antenna proteins. Our main suggestion is that a conformational change of helix H5 (known also as helix D) forces conformational changes in the macrocycle of Chl a 614 is implicated in the ΔA535 absorbance change and quenching during photoprotective qE. The specific features (some of them similar to those of heme domain of globins) of the b3 domain account for these traits. The model predicts that antenna proteins having b3 pigments (i.e. LHCII, CP29, CP26) can act as potential quenchers.

  4. Enhanced models for stellar Doppler noise reveal hints of a 13-year activity cycle of 55 Cancri

    NASA Astrophysics Data System (ADS)

    Baluev, Roman V.

    2015-01-01

    We consider the impact of Doppler noise models on the statistical robustness of the exoplanetary radial velocity fits. We show that the traditional model of the Doppler noise with an additive jitter can generate large non-linearity effects, decreasing the reliability of the fit, especially in the cases when a correlated Doppler noise is involved. We introduce a regularization of the additive noise model that can gracefully eliminate its singularities together with the associated non-linearity effects. We apply this approach to Doppler time series data of several exoplanetary systems. It demonstrates that our new regularized noise model yields orbital fits that have either increased or at least the same statistical robustness, in comparison with the simple additive jitter. Various statistical uncertainties in the parametric estimations are often reduced, while planet detection significance is often increased. Concerning the 55 Cnc five-planet system, we show that its Doppler data contain significant correlated (`red') noise. Its correlation time-scale is in the range from days to months, and its magnitude is much larger than the effect of the planetary N-body perturbations in the radial velocity (these perturbations thus appear undetectable). Characteristics of the red noise depend on the spectrograph/observatory, and also show a cyclic time variation in phase with the public Ca II H&K and photometry measurements. We interpret this modulation as a hint of the long-term activity cycle of 55 Cnc, similar to the solar 11-yr cycle. We estimate the 55 Cnc activity period by 12.6± ^{2.5}_{1.0} yr, with the nearest minimum presumably expected in 2014 or 2015.

  5. Quantitative analysis of BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue.

    PubMed

    Symes, Andrew J; Eilertsen, Marte; Millar, Michael; Nariculam, Joseph; Freeman, Alex; Notara, Maria; Feneley, Mark R; Patel, Hitendra R H; Patel, Hitenedra R H; Masters, John R W; Ahmed, Aamir

    2013-01-01

    Prostate carcinoma is the most common cancer in men with few, quantifiable, biomarkers. Prostate cancer biomarker discovery has been hampered due to subjective analysis of protein expression in tissue sections. An unbiased, quantitative immunohistochemical approach provided here, for the diagnosis and stratification of prostate cancer could overcome this problem. Antibodies against four proteins BTF3, HINT1, NDRG1 and ODC1 were used in a prostate tissue array (> 500 individual tissue cores from 82 patients, 41 case pairs matched with one patient in each pair had biochemical recurrence). Protein expression, quantified in an unbiased manner using an automated analysis protocol in ImageJ software, was increased in malignant vs non-malignant prostate (by 2-2.5 fold, p<0.0001). Operating characteristics indicate sensitivity in the range of 0.68 to 0.74; combination of markers in a logistic regression model demonstrates further improvement in diagnostic power. Triple-labeled immunofluorescence (BTF3, HINT1 and NDRG1) in tissue array showed a significant (p<0.02) change in co-localization coefficients for BTF3 and NDRG1 co-expression in biochemical relapse vs non-relapse cancer epithelium. BTF3, HINT1, NDRG1 and ODC1 could be developed as epithelial specific biomarkers for tissue based diagnosis and stratification of prostate cancer.

  6. Healthy household hints.

    PubMed

    Taylor, P

    1999-01-01

    Ten commonly found items that can help keep your home clean are listed. Baking soda and vinegar are effective in cleaning drains. Certain plants, including English ivy and the spider plant, filter carbon dioxide and carbon monoxide out of the air. In addition, specific brand-name products, such as Bon Ami and "Simple Green", are also good alternative cleansers. Contact information is provided.

  7. Hints on Sharing Books.

    ERIC Educational Resources Information Center

    Dorsey, Mary E., Comp.; Horne, Ulysses G., Comp.

    Based on the realization that each child must be given the opportunity to develop as a unique individual and that exposure to books expands a child's world, stimulating his creative thinking and his desire for new experiences, this booklet presents in outline form a variety of suggestions for encouraging children to share the books they have read.…

  8. High-resolution X-ray structure of the rabbit histidine triad nucleotide-binding protein 1 (rHINT1)-adenosine complex at 1.10 Å resolution.

    PubMed

    Dolot, Rafał; Ozga, Magdalena; Krakowiak, Agnieszka; Nawrot, Barbara

    2011-07-01

    Histidine triad nucleotide-binding protein 1 (HINT1) represents the most ancient and widespread branch in the histidine-triad protein superfamily. HINT1 plays an important role in various biological processes and has been found in many species. Here, the first complete structure of the rabbit HINT1-adenosine complex is reported at 1.10 Å resolution, which is one of the highest resolutions obtained for a HINT1 structure. The final structure has an R(cryst) of 14.25% (R(free) = 16.77%) and the model exhibits good stereochemical qualities. A detailed analysis of the atomic resolution data allowed an update of the details of the protein structure in comparison to previously published data.

  9. Infantile Hemangioma: A Brief Review

    PubMed Central

    BOTA, MADALINA; POPA, GHEORGHE; BLAG, CRISTINA; TATARU, ALEXANDRU

    2015-01-01

    Infantile hemangiomas as frequent infancy tumors have been a controversial issue of medical scientists worldwide. Their clinical aspects are various and their physiopathology is yet to be fully understood. Numerous publications outline the characteristics, causes, evolution possibilities and therapeutic approaches. Deciding whether to treat or not is the main question of this kind of pathology. Hemangiomas that have complications or can cause irreversible damage need therapy. This is a brief review of up-to-date information regarding the presentation of infantile hemangiomas and target-therapies. PMID:26528043

  10. Orion Flight Test Preview Briefing

    NASA Image and Video Library

    2014-11-06

    In the Kennedy Space Center’s Press Site auditorium, members of the news media are briefed on the upcoming Orion flight test by Ron Fortson, United Launch Alliance director of Mission Management. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

  11. Orion Flight Test Preview Briefing

    NASA Image and Video Library

    2014-11-06

    In the Kennedy Space Center’s Press Site auditorium, members of the news media are briefed on the upcoming Orion flight test by Bryan Austin, Lockheed Martin mission manager. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

  12. A Brief History of Acoustics

    NASA Astrophysics Data System (ADS)

    Rossing, Thomas D.

    Although there are certainly some good historical treatments of acoustics in the literature, it still seems appropriate to begin a handbook of history acoustics with a brief history of the subject. We begin by mentioning some important experiments that took place before the 19th century. Acoustics in the 19th century is characterized by describing the work of seven outstanding acousticians: Tyndall, von Helmholtz, Rayleigh, Stokes, Bell, Edison, and Koenig. Of course this sampling omits the mention of many other outstanding investigators.

  13. OCO-2 Post Launch Briefing

    NASA Image and Video Library

    2014-07-02

    Ralph Basilio, OCO-2 project manager, Jet Propulsion Laboratory, left, Mike Miller, senior vice president, Science and Environmental Satellite Programs, Orbital Sciences Space Systems Group,and Geoff Yoder, deputy associate administrator for programs, Science Mission Directorate, NASA Headquarters, right, discuss the successful launch of the Orbiting Carbon Observatory-2 (OCO-2), NASA’s first spacecraft dedicated to studying carbon dioxide, during a press briefing, Wednesday, July 2, 2014, at the Vandenberg Air Force Base, Calif. OCO-2 will measure the global distribution of carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. Photo Credit: (NASA/Bill Ingalls)

  14. OSTP FY 2014 Budget Briefing

    NASA Image and Video Library

    2013-04-10

    Director of the National Institutes of Health (NIH) Francis S. Collins, M.D., Ph.D., delivers remarks during a White House Office of Science and Technology Policy (OSTP) Fiscal Year 2014 budget briefing held with with Dr. John P. Holdren, Director of OSTP, Patricia Falcone of OSTP, Charlie Bolden from NASA, Cora Marrett from NSF, and Kathryn Sullivan from NOAA, at the American Association for the Advancement of Science (AAAS) on Wednesday, April 10, 2013 in Washington. Photo Credit: (NASA/Bill Ingalls)

  15. GOES-R Science Briefing

    NASA Image and Video Library

    2016-11-17

    In the Kennedy Space Center's Press Site auditorium, Steven Goodman, NOAA's GOES-R program scientist, speaks to the media during a mission briefing on the Geostationary Operational Environmental Satellite (GOES-R). GOES-R is the first satellite in a series of next-generation GOES satellites for NOAA, the National Oceanographic and Atmospheric Administration. It will launch to a geostationary orbit over the western hemisphere to provide images of storms and help meteorologists predict severe weather conditionals and develop long-range forecasts.

  16. GOES-R Science Briefing

    NASA Image and Video Library

    2016-11-17

    In the Kennedy Space Center's Press Site auditorium, Joseph A. Pica, director of the National Weather Service Office of Observations, speaks to the media during a mission briefing on the Geostationary Operational Environmental Satellite (GOES-R). GOES-R is the first satellite in a series of next-generation GOES satellites for NOAA, the National Oceanographic and Atmospheric Administration. It will launch to a geostationary orbit over the western hemisphere to provide images of storms and help meteorologists predict severe weather conditionals and develop long-range forecasts.

  17. OSTP FY 2014 Budget Briefing

    NASA Image and Video Library

    2013-04-10

    Dr. Kathryn D. Sullivan, Acting Under Secretary of Commerce for Oceans and Atmosphere and Acting NOAA Administrator, delivers remarks during a White House Office of Science and Technology Policy (OSTP) Fiscal Year 2014 budget briefing held with with Dr. John P. Holdren, Director of OSTP, Patricia Falcone of OSTP, Charlie Bolden from NASA, Francis Collins from NIH, and Cora Marrett from NSF, at the American Association for the Advancement of Science (AAAS) on Wednesday, April 10, 2013 in Washington. Photo Credit: (NASA/Bill Ingalls)

  18. GOES-R Science Briefing

    NASA Image and Video Library

    2016-11-17

    In the Kennedy Space Center's Press Site auditorium, Damon Penn, assistant administrator for response at the Federal Emergency Management Agency, speaks to the media during a mission briefing on the Geostationary Operational Environmental Satellite (GOES-R). GOES-R is the first satellite in a series of next-generation GOES satellites for NOAA, the National Oceanographic and Atmospheric Administration. It will launch to a geostationary orbit over the western hemisphere to provide images of storms and help meteorologists predict severe weather conditionals and develop long-range forecasts.

  19. GOES-R Science Briefing

    NASA Image and Video Library

    2016-11-17

    In the Kennedy Space Center's Press Site auditorium, Sandra Cauffman, deputy director of NASA's Earth Science Division, speaks to the media during a mission briefing on the Geostationary Operational Environmental Satellite (GOES-R). GOES-R is the first satellite in a series of next-generation GOES satellites for NOAA, the National Oceanographic and Atmospheric Administration. It will launch to a geostationary orbit over the western hemisphere to provide images of storms and help meteorologists predict severe weather conditionals and develop long-range forecasts.

  20. Orion Flight Test Preview Briefing

    NASA Image and Video Library

    2014-11-06

    In the Kennedy Space Center’s Press Site auditorium, members of the news media are briefed on the upcoming Orion flight test by Mark Geyer, NASA Orion Program manager. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

  1. Brief interventions for alcohol problems: a review.

    PubMed

    Bien, T H; Miller, W R; Tonigan, J S

    1993-03-01

    Relatively brief interventions have consistently been found to be effective in reducing alcohol consumption or achieving treatment referral of problem drinkers. To date, the literature includes at least a dozen randomized trials of brief referral or retention procedures, and 32 controlled studies of brief interventions targeting drinking behavior, enrolling over 6000 problem drinkers in both health care and treatment settings across 14 nations. These studies indicate that brief interventions are more effective than no counseling, and often as effective as more extensive treatment. The outcome literature is reviewed, and common motivational elements of effective brief interventions are described. There is encouraging evidence that the course of harmful alcohol use can be effectively altered by well-designed intervention strategies which are feasible within relatively brief-contact contexts such as primary health care settings and employee assistance programs. Implications for future research and practice are considered.

  2. Using the Internet to Help With Diet, Weight, and Physical Activity: Results From the Health Information National Trends Survey (HINTS)

    PubMed Central

    McCully, Scout N; Don, Brian P

    2013-01-01

    Background The Internet offers a viable platform for cost-effective and wide-reaching health interventions. However, little is known about use of the Internet to help with diet, weight, and physical activity (DWPA) using a nationally representative sample from the United States. Objective To (1) assess the demographic characteristics of people who use the Internet to help with DWPA, (2) assess whether usage trends changed over time, and (3) investigate the associations between using the Internet for DWPA and health behaviors. Methods Data on Internet users from the 2007 and 2011 iterations of the Health Information National Trends Survey (HINTS), N=4827 were analyzed using multiple logistic regression to determine the demographic correlates of using the Internet for help with DWPA. Multiple linear regression was used to test the associations between Internet use for DWPA and three health behaviors: fruit intake, vegetable intake, and physical activity. Results A larger percentage of Internet users used the Internet for DWPA in 2011 (42.83%) than in 2007 (40.43%). In general, Internet users who were younger (OR 0.98, P<.001), more educated (OR 1.40, P<.001), married (OR 1.06, P=.03), of a minority race (non-Hispanic blacks: OR 1.14, P=.02; Hispanics: OR 1.42, P=.01), and who had a higher Body Mass Index (BMI) (OR 1.04, P<.001) were more likely to use the Internet for DWPA. Across survey years, gender was not associated with using the Internet for DWPA (OR 1.03, P=.12), but there was a significant interaction between survey year and gender (OR 1.95, P=.002); in 2007, men were more likely to use the Internet for DWPA, but women were more likely to do so in 2011. Using the Internet for DWPA was associated with more vegetable intake (B=.22, P=.002), more fruit intake (B=.19, P=.001), and more moderate exercise (B=.25, P=.001), although the strength of the associations between using the Internet for DWPA and fruit intake and exercise was weaker in 2011 than in 2007

  3. Ethics in construction project briefing.

    PubMed

    Fellows, Richard; Liu, Anita; Storey, Colin

    2004-04-01

    The research reported in this paper set out to investigate ethics in the initial stages of construction projects. Briefing is the first real contact stage between the commissioner (client/employer) of a project--at this stage a potential project--and those involved in project realization--the designers and, subsequently, the constructors. It is well known that early decisions are of greatest impact and so, the importance of the initial contacts, communications and consequent decisions are paramount. Different project participants are known to pursue individual objectives to varying degrees as well as possessing different perspectives and perceptions and operating/behaving in different ways. Hence, determination of the appropriate form, content etc. of a project is, inevitably, a matter of exercising value judgements and compromises and so, involves ethical considerations. A case study of a project through the briefing stage is reported and analysed, from initial contacts to scheme approval. It is apparent that a number of ethical concerns are manifest through the various actions of the major participants.

  4. Global warming: The complete briefing

    SciTech Connect

    Houghton, J.

    1994-12-31

    John Houghton has drawn on the exhaustive efforts of the Intergovernmental Panel on Climate Change (IPCC) to produce a notably compact, impeccably complete and authoritative, meticulously balanced, and lucidly presented guide to the complex yet vital issue of global warming. Its subtitle is not mere hyperbole: this truly is a complete briefing. Certainly, one could not ask for a more authoritative brief: Houghton has led an imposing series of national and international efforts relating to climate, including the most recent scientific assessments of the IPCC. Citing many concrete examples, Houghton begins by convincing that climate truly is important to humankind and that climate is far from constant. He then elucidates the mechanisms that maintain the benign climate of our planet, providing in the process, for example, the most accurate explanation of the natural greenhouse effect that has yet appeared in print. He then treats the individual greenhouse gases responsible for maintaining the earth`s warmth and presents projections of their probable future concentrations as influenced by human activities. Further chapters deal with conclusions drawn from climate models, estimates of the impacts on human activities, and possible policies and actions to mitigate or alleviate the changes and their consequences.

  5. TEAC Exercise Workbook: Writing the "Inquiry Brief" and "Inquiry Brief Proposal"

    ERIC Educational Resources Information Center

    Teacher Education Accreditation Council, 2010

    2010-01-01

    This workbook is about producing the "Inquiry Brief" or "Inquiry Brief Proposal" for TEAC (Teacher Education Accreditation Council) accreditation. It is designed as a companion to the TEAC "Guide to Accreditation." The exercises in this workbook are selected by the writing workshop presenters to help program faculty get started on their "Brief."…

  6. 37 CFR 41.66 - Time for filing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Time for filing briefs. 41.66... for filing briefs. (a) An appellant's brief must be filed no later than two months from the latest.... The time for filing an appellant's brief or an amended appellant's brief may not be extended. (b) Once...

  7. 29 CFR 2200.93 - Briefs before the Commission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Briefs before the Commission. 2200.93 Section 2200.93 Labor... Posthearing Procedures § 2200.93 Briefs before the Commission. (a) Requests for briefs. The Commission ordinarily will request the parties to file briefs on issues before the Commission. After briefs are...

  8. Anthropic Rock: a brief history

    NASA Astrophysics Data System (ADS)

    Cathcart, R. B.

    2011-03-01

    Stone tool-making is a reductive process. Synthetic rock manufacturing, preeminently an additive process, will not for-ever be confined to only the Earth-biosphere. This brief focuses on humanity's ancient past, hodiernal and possible future even more massive than present-day creation of artificial rocks within our exploitable Solar System. It is mostly Earth-centric account that expands the factual generalities underlying the unique non-copyrighted systemic technogenic rock classification first publicly presented (to the American Geological Society) during 2001, by its sole intellectual innovator, James Ross Underwood, Jr. His pioneering, unique exposition of an organization of this ever-increasingly important aspect of the Anthropic Rock story, spatially expansive material lithification, here is given an amplified discussion for the broader geo and space science social group-purpose of encouragement of a completer 21st Century treatment of Underwood's explicative subject-chart (Fig. 2).

  9. Legal briefing: Healthcare ethics committees.

    PubMed

    Pope, Thaddeus Mason

    2011-01-01

    This issue's "Legal Briefing" column covers recent legal developments involving institutional healthcare ethics committees. This topic has been the subject of recent articles in JCE. Healthcare ethics committees have also recently been the subject of significant public policy attention. Disturbingly, Bobby Schindler and others have described ethics committees as "death panels." But most of the recent attention has been positive. Over the past several months, legislatures and courts have expanded the use of ethics committees and clarified their roles concerning both end-of-life treatment and other issues. These developments are usefully grouped into the following eight categories: 1. Existence and availability. 2. Membership and composition. 3. Operating procedures. 4. Advisory roles. 5. Decision-making and gate-keeping roles. 6. Confidentiality. 7. Immunity. 8. Litigation and court cases.

  10. Orion Flight Test Preview Briefing

    NASA Image and Video Library

    2014-11-06

    In the Kennedy Space Center’s Press Site auditorium, members of the news media are briefed on the upcoming Orion flight test by Jeremy Graeber, Orion Recovery Director in Ground Systems Development and Operations at Kennedy. Also participating in the news conference are Bryan Austin, Lockheed Martin mission manager, left, and Ron Fortson, United Launch Alliance director of Mission Management. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

  11. Orion Flight Test Preview Briefing

    NASA Image and Video Library

    2014-11-06

    In the Kennedy Space Center’s Press Site auditorium, members of the news media are briefed on the upcoming Orion flight test by Mark Geyer, NASA Orion Program manager. Also participating in the news conference are Bill Hill, NASA deputy associate administrator for Exploration Systems Development, left, and Bryan Austin, Lockheed Martin mission manager. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

  12. Orion Flight Test Preview Briefing

    NASA Image and Video Library

    2014-11-06

    In the Kennedy Space Center’s Press Site auditorium, members of the news media are briefed on the upcoming Orion flight test by Mark Geyer, NASA Orion Program manager. Also participating in the news conference are Bryan Austin, Lockheed Martin mission manager, center, and Jeremy Graeber, Orion Recovery Director in Ground Systems Development and Operations at Kennedy. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

  13. Orion Flight Test Preview Briefing

    NASA Image and Video Library

    2014-11-06

    In the Kennedy Space Center’s Press Site auditorium, members of the news media are briefed on the upcoming Orion flight test by Bill Hill, NASA deputy associate administrator for Exploration Systems Development. Mark Geyer, NASA Orion Program manager, is on the right. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

  14. Orion Flight Test Preview Briefing

    NASA Image and Video Library

    2014-11-06

    In the Kennedy Space Center’s Press Site auditorium, members of the news media are briefed on the upcoming Orion flight test by Jeremy Graeber, Orion Recovery Director in Ground Systems Development and Operations at Kennedy. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

  15. Internship or Indenture? Research Brief. Edition 2

    ERIC Educational Resources Information Center

    Sutton Trust, 2014

    2014-01-01

    This brief analyzes the latest higher education data and government wage statistics to examine the number of unpaid graduate interns in the United Kingdom and the cost to an individual of doing an unpaid internship. It also includes newly published Ipsos Mori polling on attitudes to unpaid internships. Key findings in this brief include: (1) 31%…

  16. The GO4KIDDS Brief Adaptive Scale

    ERIC Educational Resources Information Center

    Perry, Adrienne; Taheri, Azin; Ting, Victoria; Weiss, Jonathan

    2015-01-01

    Background: Accurate measurement of adaptive behaviour is important in both clinical and research contexts. While several good clinical measures exist, as well as brief research measures for adults with intellectual disability, there is need for a brief and efficient measure for research with children and youth. We present preliminary psychometric…

  17. 45 CFR 99.31 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Posthearing briefs. 99.31 Section 99.31 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROCEDURE FOR HEARINGS FOR THE CHILD CARE AND DEVELOPMENT FUND Posthearing Procedures, Decisions § 99.31 Posthearing briefs. The...

  18. Protection Against Brief Interruptions Of Power

    NASA Technical Reports Server (NTRS)

    Casad, Theodore A.

    1989-01-01

    Rotating standby power system compensates for brief interruptions in commercial power supply. System furnishes few cycles of alternating current from its stored rotational energy. Protects equipment vulnerable to brief losses of power; for example, prevents computers from erroneously suppressing or adding bits to data being handled at moment of power failure.

  19. Internship or Indenture? Research Brief. Edition 2

    ERIC Educational Resources Information Center

    Sutton Trust, 2014

    2014-01-01

    This brief analyzes the latest higher education data and government wage statistics to examine the number of unpaid graduate interns in the United Kingdom and the cost to an individual of doing an unpaid internship. It also includes newly published Ipsos Mori polling on attitudes to unpaid internships. Key findings in this brief include: (1) 31%…

  20. 14 CFR 91.519 - Passenger briefing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... briefed on— (1) Smoking. Each passenger shall be briefed on when, where, and under what conditions smoking... Regulations require passenger compliance with lighted passenger information signs and no smoking placards, prohibit smoking in lavatories, and require compliance with crewmember instructions with regard to...

  1. 14 CFR 91.519 - Passenger briefing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... briefed on— (1) Smoking. Each passenger shall be briefed on when, where, and under what conditions smoking... Regulations require passenger compliance with lighted passenger information signs and no smoking placards, prohibit smoking in lavatories, and require compliance with crewmember instructions with regard to...

  2. 14 CFR 91.519 - Passenger briefing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... briefed on— (1) Smoking. Each passenger shall be briefed on when, where, and under what conditions smoking... Regulations require passenger compliance with lighted passenger information signs and no smoking placards, prohibit smoking in lavatories, and require compliance with crewmember instructions with regard to...

  3. 14 CFR 91.519 - Passenger briefing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... briefed on— (1) Smoking. Each passenger shall be briefed on when, where, and under what conditions smoking... Regulations require passenger compliance with lighted passenger information signs and no smoking placards, prohibit smoking in lavatories, and require compliance with crewmember instructions with regard to...

  4. 14 CFR 91.519 - Passenger briefing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations require passenger compliance with lighted passenger information signs and no smoking placards, prohibit smoking in lavatories, and require compliance with crewmember instructions with regard to these... briefed on— (1) Smoking. Each passenger shall be briefed on when, where, and under what conditions...

  5. 42 CFR 430.100 - Posthearing briefs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Posthearing briefs. 430.100 Section 430.100 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... conclusions of law. The presiding officer may also permit reply briefs....

  6. 45 CFR 99.31 - Posthearing briefs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Posthearing briefs. 99.31 Section 99.31 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROCEDURE FOR HEARINGS FOR THE... fact and conclusions of law. The presiding officer shall also fix the time for reply briefs,...

  7. 39 CFR 955.10 - Prehearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Prehearing briefs. 955.10 Section 955.10 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE BEFORE THE POSTAL SERVICE BOARD OF CONTRACT APPEALS § 955.10 Prehearing briefs. Based on an examination of the documentation described in...

  8. The GO4KIDDS Brief Adaptive Scale

    ERIC Educational Resources Information Center

    Perry, Adrienne; Taheri, Azin; Ting, Victoria; Weiss, Jonathan

    2015-01-01

    Background: Accurate measurement of adaptive behaviour is important in both clinical and research contexts. While several good clinical measures exist, as well as brief research measures for adults with intellectual disability, there is need for a brief and efficient measure for research with children and youth. We present preliminary psychometric…

  9. 50 CFR 37.33 - Environmental briefing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false Environmental briefing. 37.33 Section 37..., ARCTIC NATIONAL WILDLIFE REFUGE, ALASKA Environmental Protection § 37.33 Environmental briefing. The permittee shall provide opportunities for the Regional Director to conduct environmental and other pertinent...

  10. 50 CFR 37.33 - Environmental briefing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false Environmental briefing. 37.33 Section 37..., ARCTIC NATIONAL WILDLIFE REFUGE, ALASKA Environmental Protection § 37.33 Environmental briefing. The permittee shall provide opportunities for the Regional Director to conduct environmental and other pertinent...

  11. 50 CFR 37.33 - Environmental briefing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Environmental briefing. 37.33 Section 37..., ARCTIC NATIONAL WILDLIFE REFUGE, ALASKA Environmental Protection § 37.33 Environmental briefing. The permittee shall provide opportunities for the Regional Director to conduct environmental and other pertinent...

  12. 50 CFR 37.33 - Environmental briefing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Environmental briefing. 37.33 Section 37..., ARCTIC NATIONAL WILDLIFE REFUGE, ALASKA Environmental Protection § 37.33 Environmental briefing. The permittee shall provide opportunities for the Regional Director to conduct environmental and other pertinent...

  13. 50 CFR 37.33 - Environmental briefing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false Environmental briefing. 37.33 Section 37..., ARCTIC NATIONAL WILDLIFE REFUGE, ALASKA Environmental Protection § 37.33 Environmental briefing. The permittee shall provide opportunities for the Regional Director to conduct environmental and other pertinent...

  14. Evaluating Mentoring Programs. P/PV Brief

    ERIC Educational Resources Information Center

    Grossman, Jean Baldwin

    2009-01-01

    This methodological brief is designed to provide both program operators and researchers with practical advice about how to assess a program's implementation and impact. Adapted from an article that first appeared in "The Handbook of Youth Mentoring" (DuBois and Karcher, ed. 2005), the brief focuses on the evaluation of mentoring programs, but the…

  15. 37 CFR 41.37 - Appeal brief.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... COMMERCE PRACTICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Ex Parte Appeals § 41.37 Appeal brief. (a... in § 41.20(b)(4) must be paid within the time period specified in § 41.45 to avoid dismissal of an... interest. A statement identifying by name the real party in interest at the time the appeal brief is filed...

  16. Delta WIND Mission Science Briefing

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The science objectives of the WIND mission are to: 1) provide complete plasma, energetic particle, and magnetic field input for magnetospheric and ionospheric studies; 2) Determine the magnetospheric output to interplanetary space in the up-stream region; 3) Investigate basic plasma processes occurring in the near-Earth solar wind; and 4) Provide baseline ecliptic plane observations to be used in heliospheric latitudes from ULYSSES. The WIND science briefing is presented by George Diller, NASA public affairs; Dr. Robert L. Carovillano, Project Scientist for the Global Geospace Science Initiative, NASA Headquarters; Dr. Mario H. Acuna, Project Scientist for the WIND Project, Goddard Space Flight Center (GSFC); Dr. Keith W. Ogilvie, Principle Investigator, Solar Wind Experiment at GSFC; Dr. Jean Louis Bougeret, Principle Investigator, Radio/Plasma Wave Experiment, Paris; and Dr. Eugeny Mazets, Co-Principle Investigator, Russian Gamma Ray Spectrometer Instrument, St. Pertersburg, Russia. Dr. Carovillano presents a cartoon slide of the Solar Terrestrial System and describes the Sun and the Magnetic field of the Earth. Dr. Acuna also presents a cartoon slide describing GEOTAIL, POLAR, WIND, SOHO, ULYSSES and Cluster which are the various tools used to study the complex solar terrestrial system. Dr. Ogilvie explains four particle and wave instruments on WIND. These instruments will be used to study the contributions and characteristics of plasma and plasma waves that occur in the solar wind. Dr. Bougeret explains the European participation in the WIND mission. He also shows a slide presentation of SOHO and the CLUSTER spacecraft. Dr. Mazets explains the main objective of the Transient Gamma Ray Spectrometer (TGRS) aboard the WIND spacecraft, which is to perform high resolution measurements of Gamma Ray Burst spectra and time histories, with emphasis on the search for line features in the energy spectra. The briefing ends with a question and answer period. See NONP

  17. XTE Science Briefing from KSCNF

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The X-ray Timing Explorer (XTE), launched on Dec. 30, 1995, is a Satellite that observes the fast-moving, high-energy worlds of black holes, neutron stars, x-ray pulsars and bursts of X-rays that light up the sky and then disappear forever. This videotape presents a pre-launch science briefing to the press by a few of the scientist and managers associated with the XTE satellite. The moderator for the press briefing is Jim Sahli, from the Public Affairs Office at Goddard Space Flight Center (GSFC). He introduces Alan Bunner, of the High Energy Astrophysics at NASA Headquarters; Fred Lamb, from the University of Illinois; Richard Mashotzky, X Ray Scientist at GSFC; Rick Rothschild, Principal Investigator from the University of California at San Diego; and Dale Schultz, the XTE project manager at GSFC. Dr. Bunner explains the electromagnetic spectrum, the placement of x-rays and the importance of the XTE observations to a better understanding of the Universe. Dr. Lamb, explains the difference between white dwarfs, neutron stars and black holes, and the type of observations that the XTE will give to a further understanding of these phenomena. Dr. Mashotzky expands the viewpoint to beyond the galaxy, and explains the interests of scientists who hope to use XTE to further study Quasars and Active Galactic Nuclei. Dr. Rothschild reviews some of the features of XTE, using a diagram to show the features of interest, such as the X ray Telescopes, and the collecting Proportional Counter Array (PCA.) Mr. Schultz presents a videotape tour of the XTE, in which he shows the scientific instruments and the other features of the satellite. In this tour, the source of each of the instruments is noted. Questions from the members of the press are then fielded. Many of the questions are about the cost of the XTE and any problems that are anticipated in regards to the launch.

  18. 19 CFR 207.67 - Posthearing briefs and statements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.67 Posthearing briefs and statements. (a) Briefs from parties. Any party to a five-year review may file with the Secretary a posthearing brief...

  19. 6 CFR 13.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Post-hearing briefs. 13.36 Section 13.36... § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ will fix the time for filing such briefs. Such briefs...

  20. Screeners and brief assessment methods.

    PubMed

    Pérez Rodrigo, Carmen; Morán Fagúndez, Luis Juan; Riobó Serván, Pilar; Aranceta Bartrina, Javier

    2015-02-26

    In the last two decades easy-to-use simple instruments have been developed and validated to assess specific aspects of the diet or a general profile that can be compared with a reference dietary pattern as the Mediterranean Diet or with the recommendations of the Dietary Guidelines. Brief instruments are rapid, simple and easy to use tools that can be implemented by unskilled personnel without specific training. These tools are useful both in clinical settings and in Primary Health Care or in the community as a tool for triage, as a screening tool to identify individuals or groups of people at risk who require further care or even they have been used in studies to investigate associations between specific aspects of the diet and health outcomes. They are also used in interventions focused on changing eating behaviors as a diagnostic tool, for self-evaluation purposes, or to provide tailored advice in web based interventions or mobile apps. There are some specific instruments for use in children, adults, elderly or specific population groups.

  1. NASA Tech Briefs, February 2009

    NASA Technical Reports Server (NTRS)

    2009-01-01

    Tech Briefs are short announcements of innovations originating from research and development activities of the National Aeronautics and Space Administration. They emphasize information considered likely to be transferable across industrial, regional, or disciplinary lines and are issued to encourage commercial application. Topics covered include: Measuring Low Concentrations of Liquid Water in Soil; The Mars Science Laboratory Touchdown Test Facility; Non-Contact Measurement of Density and Thickness Variation in Dielectric Materials; Compact Microwave Fourier Spectrum Analyzer; InP Heterojunction Bipolar Transistor Amplifiers to 255 GHz; Combinatorial Generation of Test Suites; In-Phase Power-Combined Frequency Tripler at 300 GHz; Electronic System for Preventing Airport Runway Incursions; Smaller but Fully Functional Backshell for Cable Connector; Glove-Box or Desktop Virtual-Reality System; Composite Layer Manufacturing with Fewer Interruptions; Improved Photoresist Coating for Making CNT Field Emitters; A Simplified Diagnostic Method for Elastomer Bond Durability; Complex Multifunctional Polymer/Carbon-Nanotube Composites; Very High Output Thermoelectric Devices Based on ITO Nanocomposites; Reducing Unsteady Loads on a Piggyback Miniature Submarine; Ultrasonic/Sonic Anchor; Grooved Fuel Rings for Nuclear Thermal Rocket Engines; Pulsed Operation of an Ion Accelerator; Autonomous Instrument Placement for Mars Exploration Rovers; Mission and Assets Database; TCP/IP Interface for the Satellite Orbit Analysis Program (SOAP); Trajectory Calculator for Finite-Radius Cutter on a Lathe; Integrated System Health Management Development Toolkit.

  2. Cancer Vaccines: A Brief Overview.

    PubMed

    Thomas, Sunil; Prendergast, George C

    2016-01-01

    Vaccine approaches for cancer differ from traditional vaccine approaches for infectious disease in tending to focus on clearing active disease rather than preventing disease. In this review, we provide a brief overview of different types of vaccines and adjuvants that have been investigated for the purpose of controlling cancer burdens in patients, some of which are approved for clinical use or in late-stage clinical trials, such as the personalized dendritic cell vaccine sipuleucel-T (Provenge) and the recombinant viral prostate cancer vaccine PSA-TRICOM (Prostvac-VF). Vaccines against human viruses implicated in the development and progression of certain cancers, such as human papillomavirus in cervical cancer, are not considered here. Cancers express "altered self" antigens that tend to induce weaker responses than the "foreign" antigens expressed by infectious agents. Thus, immune stimulants and adjuvant approaches have been explored widely. Vaccine types considered include autologous patient-derived immune cell vaccines, tumor antigen-expressing recombinant virus vaccines, peptide vaccines, DNA vaccines, and heterologous whole-cell vaccines derived from established human tumor cell lines. Opportunities to develop effective cancer vaccines may benefit from seminal recent advances in understanding how immunosuppressive barricades are erected by tumors to mediate immune escape. In particular, targeted ablation of these barricades with novel agents, such as the immune checkpoint drug ipilimumab (anti-CTLA-4) approved recently for clinical use, may offer significant leverage to vaccinologists seeking to control and prevent malignancy.

  3. Orion Flight Test Preview Briefing

    NASA Image and Video Library

    2014-11-06

    In the Kennedy Space Center’s Press Site auditorium, members of the news media are briefed on the upcoming Orion flight test. From left are: Rachel Kraft, NASA Public Affairs, Bill Hill, NASA deputy associate administrator for Exploration Systems Development, Mark Geyer, NASA Orion Program manager, Bryan Austin, Lockheed Martin mission manager, Jeremy Graeber, Operations Integration Branch of Ground Systems Development and Operations at Kennedy, and Ron Fortson, United Launch Alliance director of Mission Management. Mike Sarafin, NASA's lead flight director, participated by video from the Johnson Space Center. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

  4. STS-99 Prelaunch Press Briefing

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The primary objective of the STS-99 mission was to complete high resolution mapping of large sections of the Earth's surface using the Shuttle Radar Topography Mission (SRTM), a specially modified radar system. This radar system produced unrivaled 3-D images of the Earth's Surface. The mission was launched at 12:31 on February 11, 2000 onboard the space shuttle Endeavour, and led by Commander Kevin Kregel. The crew was Pilot Dominic L. Pudwill Gorie and Mission Specialists Janet L. Kavandi, Janice E. Voss, Mamoru Mohri from the National Space Development Agency (Japanese Space Agency), and Gerhard P. J. Thiele from DARA (German Space Agency). This videotape shows a press briefing about a mechanical problem that the shuttle was having. There was discussion about possibly scrubbing the launch due to the problem with the Enhanced Master Events Controller. A problem with a fuel pump part had also become evident and there was discussion about the impact that this could have on the flight.

  5. Engineering Technical Review Planning Briefing

    NASA Technical Reports Server (NTRS)

    Gardner, Terrie

    2012-01-01

    The general topics covered in the engineering technical planning briefing are 1) overviews of NASA, Marshall Space Flight Center (MSFC), and Engineering, 2) the NASA Systems Engineering(SE) Engine and its implementation , 3) the NASA Project Life Cycle, 4) MSFC Technical Management Branch Services in relation to the SE Engine and the Project Life Cycle , 5) Technical Reviews, 6) NASA Human Factor Design Guidance , and 7) the MSFC Human Factors Team. The engineering technical review portion of the presentation is the primary focus of the overall presentation and will address the definition of a design review, execution guidance, the essential stages of a technical review, and the overall review planning life cycle. Examples of a technical review plan content, review approaches, review schedules, and the review process will be provided and discussed. The human factors portion of the presentation will focus on the NASA guidance for human factors. Human factors definition, categories, design guidance, and human factor specialist roles will be addressed. In addition, the NASA Systems Engineering Engine description, definition, and application will be reviewed as background leading into the NASA Project Life Cycle Overview and technical review planning discussion.

  6. Drought Resilience and Water Conservation Technical Brief

    EPA Pesticide Factsheets

    In many areas of the US, the frequency, intensity, and duration of drought events are increasing, this brief highlights EPA drought and conservation activities across the nation and includes links to additional materials and reference documents.

  7. CLA Brief: Distribution of Federal Government Publications

    ERIC Educational Resources Information Center

    Land, Brian; Kitchen, Paul

    1976-01-01

    The Canadian Library Association submits a brief to the Canadian legislature. History, purpose, and status of government publications and their catalogs and distribution are discussed. Recommendations are provided for an improved government publications program. (LS)

  8. A Brief History of CME Science

    NASA Technical Reports Server (NTRS)

    Alexander, David; Richardson, Ian G.; Zurbuchen, Thomas H.

    2006-01-01

    We present here a brief summary of the rich heritage of observational and theoretical research leading to the development of our current understanding of the initiation, structure, and evolution of Coronal Mass Ejections.

  9. 39 CFR 955.10 - Prehearing briefs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CONTRACT APPEALS § 955.10 Prehearing briefs. Link to an amendment published at 76 FR 37660, June 28, 2011... revising the first sentence, effective July 28, 2011. For the convenience of the user, the revised text...

  10. A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5′-monophosphate at 1.38 Å resolution

    PubMed Central

    Dolot, Rafał; Ozga, Magdalena; Włodarczyk, Artur; Krakowiak, Agnieszka; Nawrot, Barbara

    2012-01-01

    Histidine triad nucleotide-binding protein 1 (HINT1) represents the most ancient and widespread branch of the histidine triad protein superfamily. HINT1 plays an important role in various biological processes and has been found in many species. Here, the structure of the human HINT1–adenosine 5′-monophosphate (AMP) complex at 1.38 Å resolution obtained from a new monoclinic crystal form is reported. The final structure has R cryst = 0.1207 (R free = 0.1615) and the model exhibits good stereochemical quality. Detailed analysis of the high-resolution data allowed the details of the protein structure to be updated in comparison to the previously published data. PMID:22869114

  11. A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 Å resolution.

    PubMed

    Dolot, Rafał; Ozga, Magdalena; Włodarczyk, Artur; Krakowiak, Agnieszka; Nawrot, Barbara

    2012-08-01

    Histidine triad nucleotide-binding protein 1 (HINT1) represents the most ancient and widespread branch of the histidine triad protein superfamily. HINT1 plays an important role in various biological processes and has been found in many species. Here, the structure of the human HINT1-adenosine 5'-monophosphate (AMP) complex at 1.38 Å resolution obtained from a new monoclinic crystal form is reported. The final structure has R(cryst) = 0.1207 (R(free) = 0.1615) and the model exhibits good stereochemical quality. Detailed analysis of the high-resolution data allowed the details of the protein structure to be updated in comparison to the previously published data.

  12. Brief Cognitive Behavioral Therapy for Military Populations

    DTIC Science & Technology

    2012-10-01

    NOTES 14. ABSTRACT The purpose of this study is to compare a brief-cognitive behavioral therapy (B- CBT ) to usual care in the treatment of active...The primary purpose of this study is to compare the effectiveness of brief cognitive-behavioral therapy (B- CBT ) for the treatment of suicidality...involve tests conducted comparing improvement following B- CBT ( treatment duration of 12 weeks) to treatment as usual (TAU). The primary outcome

  13. Cumulative Effect of Repeated Brief Cerebral Ischemia

    DTIC Science & Technology

    1993-05-31

    KL, Pohost GM and Conger KA, Correlating EEG and Lactate Kinetics During Repeated Brief Cerebral Ischemia, Proceedings of the American Heart Association 1993...Cornelating EEG and Lactate Kinetics During Repeated Brief Cerebral Ischemia, Proceedings of the American Heart Association 1993. 4) HP Hetherington...thes Bernhard Foundation. ass- 134 󈧑&.1 n5. 9# American Heart Association 026085 66th Scientific Sessions Abstract Form Medical Research Nursing

  14. Cumulative Index to NASA Tech Briefs

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Tech Briefs are short announcements of new technology derived from the R&D activities of the National Aeronautics and Space Administration. This Index to NASA Tech Briefs lists the technological innovations derived from the U.S. space program and published during the period January through December 1968. A new five year cycle of cumulative indexes begins with this index. The main section is arranged in six categories: Electrical (Electronic); Physical Sciences (Energy Sources); Materials (Chemistry); Life Sciences; Mechanical; and Computer Programs.

  15. NASA Tech Briefs, January 2009

    NASA Technical Reports Server (NTRS)

    2009-01-01

    Tech Briefs are short announcements of innovations originating from research and development activities of the National Aeronautics and Space Administration. They emphasize information considered likely to be transferable across industrial, regional, or disciplinary lines and are issued to encourage commercial application. Topics covered include: The Radio Frequency Health Node Wireless Sensor System; Effects of Temperature on Polymer/Carbon Chemical Sensors; Small CO2 Sensors Operate at Lower Temperature; Tele-Supervised Adaptive Ocean Sensor Fleet; Synthesis of Submillimeter Radiation for Spectroscopy; 100-GHz Phase Switch/Mixer Containing a Slot-Line Transition; Generating Ka-Band Signals Using an X-Band Vector Modulator; SiC Optically Modulated Field-Effect Transistor; Submillimeter-Wave Amplifier Module with Integrated Waveguide Transitions; Metrology System for a Large, Somewhat Flexible Telescope; Economical Implementation of a Filter Engine in an FPGA; Improved Joining of Metal Components to Composite Structures; Machined Titanium Heat-Pipe Wick Structure; Gadolinia-Doped Ceria Cathodes for Electrolysis of CO2; Utilizing Ocean Thermal Energy in a Submarine Robot; Fuel-Cell Power Systems Incorporating Mg-Based H2 Generators; Alternative OTEC Scheme for a Submarine Robot; Sensitive, Rapid Detection of Bacterial Spores; Adenosine Monophosphate-Based Detection of Bacterial Spores; Silicon Microleaks for Inlets of Mass Spectrometers; CGH Figure Testing of Aspherical Mirrors in Cold Vacuums; Series-Coupled Pairs of Silica Microresonators; Precise Stabilization of the Optical Frequency of WGMRs; Formation Flying of Components of a Large Space Telescope; Laser Metrology Heterodyne Phase-Locked Loop; Spatial Modulation Improves Performance in CTIS; High-Performance Algorithm for Solving the Diagnosis Problem; Truncation Depth Rule-of-Thumb for Convolutional Codes; Efficient Method for Optimizing Placement of Sensors.

  16. NASA Tech Briefs, February 2012

    NASA Technical Reports Server (NTRS)

    2012-01-01

    This issue contains the following briefs: (1) Optical Comb from a Whispering Gallery Mode Resonator for Spectroscopy and Astronomy Instruments Calibration (2) Real-Time Flight Envelope Monitoring System (3) Nemesis Autonomous Test System (4) Mirror Metrology Using Nano-Probe Supports (5) Automated Lab-on-a-Chip Electrophoresis System (6) Techniques for Down-Sampling a Measured Surface Height Map for Model Validation (7) Multi-Component, Multi-Point Interferometric Rayleigh/Mie Doppler Velocimeter (8) Frequency to Voltage Converter Analog Front-End Prototype (9) Dust-Tolerant Intelligent Electrical Connection System (10) Gigabit Ethernet Asynchronous Clock Compensation FIFO (11) High-Speed, Multi-Channel Serial ADC LVDS Interface for Xilinx Virtex-5 FPGA (12) Glovebox for GeoLab Subsystem in HDU1-PEM (13) Modified Process Reduces Porosity when Soldering in Reduced Gravity Environments (14) Use of Functionalized Carbon Nanotubes for Covalent Attachment of Nanotubes to Silicon (15) Flexible Plug Repair for Shuttle Wing Leading Edge (16) Three Dimensionally Interlinked, Dense, Solid Form of Single-Walled CNT Ropes (17) Axel Robotic Platform for Crater and Extreme Terrain Exploration (18) Site Tamper and Material Plow Tool - STAMP (19) Magnetic Interface for Segmented Mirror Assembly (20) Transpiration-Cooled Spacecraft-Insulation-Repair Fasteners (21) Fluorescence-Based Sensor for Monitoring Activation of Lunar Dust (22) Aperture Ion Source (23) Virtual Ultrasound Guidance for Inexperienced Operators (24) Model-Based Fault Diagnosis: Performing Root Cause and Impact Analyses in Real Time (25) Interactive Schematic Integration Within the Propellant System Modeling Environment (26) Magnetic and Electric Field Polarizations of Oblique Magnetospheric Chorus Waves (27) Variable Sampling Mapping.

  17. 76 FR 50715 - Briefing on Partner Vetting System Pilot Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ...; ] DEPARTMENT OF STATE Agency for International Development Briefing on Partner Vetting System Pilot Program... briefing. SUMMARY: Notice is hereby given of a briefing on the Partner Vetting System (PVS) pilot program. The objective of the briefing is to provide information about the PVS pilot program. Members of the...

  18. 29 CFR 2200.93 - Briefs before the Commission.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Consequences of failure to timely file brief. The Commission may decline to accept a brief that is not timely... contents. A brief in excess of 15 pages shall include a table of contents. (g) Failure to meet requirements... the criteria of § 2200.24. Any brief of an amicus curiae must meet the requirements of paragraphs...

  19. 29 CFR 2200.93 - Briefs before the Commission.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Consequences of failure to timely file brief. The Commission may decline to accept a brief that is not timely... contents. A brief in excess of 15 pages shall include a table of contents. (g) Failure to meet requirements... the criteria of § 2200.24. Any brief of an amicus curiae must meet the requirements of paragraphs...

  20. 38 CFR 42.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Post-hearing briefs. 42...) STANDARDS IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The...

  1. 22 CFR 1422.14 - Filing of briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Filing of briefs. 1422.14 Section 1422.14... PROCEEDINGS § 1422.14 Filing of briefs. A party desiring to file a brief with the Board shall file the... brief under authority of this section shall be made to the Regional Director, in writing, and copies...

  2. 46 CFR 201.155 - Briefs; request for findings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Briefs; request for findings. 201.155 Section 201.155... PRACTICE AND PROCEDURE Briefs, Requests for Findings, Decisions, Exceptions (Rule 16) § 201.155 Briefs; request for findings. The time for filing briefs to the presiding officer, and extensions thereof, shall...

  3. 21 CFR 12.96 - Briefs and arguments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Briefs and arguments. 12.96 Section 12.96 Food and... PUBLIC HEARING Hearing Procedures § 12.96 Briefs and arguments. (a) Promptly after the taking of evidence is completed, the presiding officer will announce a schedule for the filing of briefs. Briefs are to...

  4. 40 CFR 27.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Post-hearing briefs. 27.36 Section 27... § 27.36 Post-hearing briefs. The presiding officer may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The presiding officer shall fix the time for...

  5. 46 CFR 502.221 - Briefs; requests for findings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Briefs; requests for findings. 502.221 Section 502.221... Briefs; Requests for Findings; Decisions; Exceptions § 502.221 Briefs; requests for findings. (a) The presiding officer shall fix the time and manner of filing briefs and any enlargement of time. The period of...

  6. 16 CFR 1502.34 - Briefs and arguments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Briefs and arguments. 1502.34 Section 1502... REGULATIONS PROCEDURES FOR FORMAL EVIDENTIARY PUBLIC HEARING Hearing Procedures § 1502.34 Briefs and arguments... schedule for the filing of briefs. Briefs are to be filed ordinarily within 45 days of the close of the...

  7. 40 CFR 179.98 - Briefs and arguments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Briefs and arguments. 179.98 Section... EVIDENTIARY PUBLIC HEARING Hearing Procedures § 179.98 Briefs and arguments. (a) Promptly after the taking of evidence is completed, the presiding officer will announce a schedule for the filing of briefs. Briefs must...

  8. 39 CFR 958.15 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Post-hearing briefs. 958.15 Section 958.15 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO CIVIL... briefs. Post-hearing briefs and reply briefs may be submitted upon such terms as established by the...

  9. 42 CFR 3.544 - Post hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Post hearing briefs. 3.544 Section 3.544 Public... ORGANIZATIONS AND PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.544 Post hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief...

  10. 18 CFR 1308.39 - Briefs and motions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Briefs and motions... DISPUTES Prehearing and Hearing Procedures § 1308.39 Briefs and motions. (a) All motions shall be accompanied by a brief or memorandum setting forth supporting authorities. Briefs in opposition to a motion...

  11. 47 CFR 1.50 - Specifications as to briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Specifications as to briefs. 1.50 Section 1.50... Procedure Pleadings, Briefs, and Other Papers § 1.50 Specifications as to briefs. The Commission's preference is for briefs that are either typewritten, prepared by other mechanical processing methods, or, in...

  12. 39 CFR 962.18 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Post-hearing briefs. 962.18 Section 962.18 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO THE PROGRAM FRAUD CIVIL REMEDIES ACT § 962.18 Post-hearing briefs. Post-hearing briefs and reply briefs may be...

  13. 29 CFR 458.86 - Filing of brief.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Filing of brief. 458.86 Section 458.86 Labor Regulations... OF CONDUCT Hearing and Related Matters § 458.86 Filing of brief. Any party desiring to submit a brief... Law Judge may grant a reasonable extension of time. Copies of such brief shall be served on all of the...

  14. Use of the Internet to Communicate with Health Care Providers in the United States: Estimates from the 2003 and 2005 Health Information National Trends Surveys (HINTS)

    PubMed Central

    Finney Rutten, Lila J; Squiers, Linda; Arora, Neeraj K; Volckmann, Lindsey; Moser, Richard P; Hesse, Bradford W

    2007-01-01

    Background Despite substantial evidence that the public wants access to Internet-based communication with health care providers, online patient-provider communication remains relatively uncommon, and few studies have examined sociodemographic and health-related factors associated with the use of online communication with health care providers at a population level. Objective The aim of the study was to use nationally representative data to report on the prevalence of and changes in use of online patient-provider communication in 2003 and 2005 and to describe sociodemographic and health-related factors associated with its use. Methods Data for this study are from two iterations of the Health Information National Trends Survey (HINTS 2003, HINTS 2005). In both years, respondents were asked whether they had ever used email or the Internet to communicate with a doctor or a doctor’s office. Adult Internet users in 2003 (n = 3982) and 2005 (n = 3244) were included in the present study. Multivariate logistic regression analysis was conducted to identify predictors for electronic communication with health care providers. Results In 2003, 7% of Internet users had communicated online with an health care provider; this prevalence significantly increased to 10% in 2005. In multivariate analyses, Internet users with more years of education, who lived in a metro area, who reported poorer health status or who had a personal history of cancer were more likely to have used online patient-provider communication. Conclusions Despite wide diffusion of the Internet, online patient-provider communication remains uncommon but is slowly increasing. Policy-level changes are needed to maximize the availability and effectiveness of online patient-provider communication for health care consumers and health care providers. Internet access remains a significant barrier to online patient-provider communication. PMID:17627929

  15. Hints for cyclical recruitment of atelectasis during ongoing mechanical ventilation in lavage and oleic acid lung injury detected by SpO₂ oscillations and electrical impedance tomography.

    PubMed

    Bodenstein, Marc; Boehme, Stefan; Wang, Hemei; Duenges, Bastian; Markstaller, Klaus

    2014-11-01

    Detection of cyclical recruitment of atelectasis after induction of lavage (LAV) or oleic acid injury (OAI) in mechanically ventilated pigs. Primary hypothesis is that oxygen oscillations within the respiratory cycle can be detected by SpO₂ recordings (direct hint). SpO₂ oscillations reflect shunt oscillations that can only be explained by cyclical recruitment of atelectasis. Secondary hypothesis is that electrical impedance tomography (EIT) depicts specific regional changes of lung aeration and of pulmonary mechanical properties (indirect hint). Three groups (each n = 7) of mechanically ventilated pigs were investigated applying above mentioned methods before and repeatedly after induction of lung injury: (1) sham treated animals (SHAM), (2) LAV, and (3) OAI. Early oxygen oscillations occurred in the LAV group (mean calculated amplitude: 73.8 mmHg reflecting shunt oscillation of 11.2% in mean). In the OAI group oxygen oscillations occurred hours after induction of lung injury (mean calculated amplitude: 57.1 mmHg reflecting shunt oscillations of 8.4% in mean). The SHAM group had no relevant oxygen oscillations (<30 mmHg, shunt oscillations < 1.5%). Synchronously to oxygen oscillations, EIT depicted (1) a decrease of ventilation in dorsal areas, (2) an increase in ventral areas, (3) a decrease of especially dependent expiratory impedance, 3) an increase in late inspiratory flow especially in the dependant areas, (4) an increase in the speed of peak expiratory flow (PEF), and (5) a decrease of dorsal late expiratory flow. SpO2 and EIT recordings detect events that are interpreted as cyclical recruitment of atelectasis.

  16. Profiling and quantitative evaluation of three Nickel-Coated magnetic matrices for purification of recombinant proteins: lelpful hints for the optimized nanomagnetisable matrix preparation

    PubMed Central

    2011-01-01

    Background Several materials are available in the market that work on the principle of protein magnetic fishing by their histidine (His) tags. Little information is available on their performance and it is often quoted that greatly improved purification of histidine-tagged proteins from crude extracts could be achieved. While some commercial magnetic matrices could be used successfully for purification of several His-tagged proteins, there are some which have been proved to operate just for a few extent of His-tagged proteins. Here, we address quantitative evaluation of three commercially available Nickel nanomagnetic beads for purification of two His-tagged proteins expressed in Escherichia coli and present helpful hints for optimized purification of such proteins and preparation of nanomagnetisable matrices. Results Marked differences in the performance of nanomagnetic matrices, principally on the basis of their specific binding capacity, recovery profile, the amount of imidazole needed for protein elution and the extent of target protein loss and purity were obtained. Based on the aforesaid criteria, one of these materials featured the best purification results (SiMAG/N-NTA/Nickel) for both proteins at the concentration of 4 mg/ml, while the other two (SiMAC-Nickel and SiMAG/CS-NTA/Nickel) did not work well with respect to specific binding capacity and recovery profile. Conclusions Taken together, functionality of different types of nanomagnetic matrices vary considerably. This variability may not only be dependent upon the structure and surface chemistry of the matrix which in turn determine the affinity of interaction, but, is also influenced to a lesser extent by the physical properties of the protein itself. Although the results of the present study may not be fully applied for all nanomagnetic matrices, but provide a framework which could be used to profiling and quantitative evaluation of other magnetisable matrices and also provide helpful hints for those

  17. Computational chemistry study of 3D-structure-function relationships for enzymes based on Markov models for protein electrostatic, HINT, and van der Waals potentials.

    PubMed

    Concu, Riccardo; Podda, Gianni; Uriarte, Eugenio; González-Díaz, Humberto

    2009-07-15

    In a significant work, Dobson and Doig (J Mol Biol 2003, 330, 771) illustrated protein prediction as enzymatic or not from spatial structure without resorting to alignments. They used 52 protein features and a nonlinear support vector machine model to classify more than 1000 proteins collected from the PDB with a 77% overall accuracy. The most useful features were: the secondary-structure content, the amino acid frequencies, the number of disulphide bonds, and the largest cleft size. Working on the same dataset used by D&D, in this article we reported a good and simple model, based on the Markov chain models (MCM), to classify protein 3D structures as enzymatic or not, taking into consideration the spatial structure without resorting to alignments. Here we define, for the first time, a general MCM to calculate the electrostatic potential, molecular vibrations, van der Waals (vdw) interactions, and hydrophobic interactions (HINT) and use them in comparative studies of potential fields and/or protein function prediction. The dataset is composed of 1371 proteins divided into 689 enzymes and 682 nonenzymes, all proteins were collected from the PDB. The best model we found was a linear model carried out with the linear discriminant analysis; it was able to classify 74.18% of the proteins using only two electrostatic potentials. In the work described here, we define 3D-HINT potentials (mu(k)) and use them for the first time to derive a classifier for protein enzymes. We analyzed ROC curves, domain of applicability, parametric assumptions, desirability maps, and also tested other nonlinear artificial neural network models which did not improve the linear model. In closing, this MCM allows a fast calculation and comparison of different potentials deriving into accurate protein 3D structure-function relationships, notably simpler than the previous.

  18. 45 CFR 79.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Post-hearing briefs. 79.36 Section 79.36 Public....36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to...

  19. 28 CFR 71.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Post-hearing briefs. 71.36 Section 71.36....36 Post-hearing briefs. ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to exceed 60...

  20. 22 CFR 35.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Post-hearing briefs. 35.36 Section 35.36...-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to exceed 60 days...

  1. 20 CFR 498.219 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Post-hearing briefs. 498.219 Section 498.219... EXCLUSIONS § 498.219 Post-hearing briefs. (a) Any party may file a post-hearing brief. (b) The ALJ may require the parties to file post-hearing briefs and may permit the parties to file reply briefs. (c) The...

  2. 34 CFR 33.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Post-hearing briefs. 33.36 Section 33.36 Education... briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing these briefs, not to exceed 60 days from the...

  3. 22 CFR 521.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Post-hearing briefs. 521.36 Section 521.36... § 521.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time not...

  4. 22 CFR 224.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Post-hearing briefs. 224.36 Section 224.36... ACT § 224.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time...

  5. 15 CFR 25.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Post-hearing briefs. 25.36 Section 25....36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to...

  6. 10 CFR 1013.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Post-hearing briefs. 1013.36 Section 1013.36 Energy... briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to exceed 60 days from the...

  7. Brief Behavioural Activation (Brief BA) for Adolescent Depression: A Pilot Study.

    PubMed

    Pass, Laura; Lejuez, Carl W; Reynolds, Shirley

    2017-07-31

    Depression in adolescence is a common and serious mental health problem. In the UK, access to evidence-based psychological treatments is limited, and training and employing therapists to deliver these is expensive. Brief behavioural activation for the treatment of depression (BATD) has great potential for use with adolescents and to be delivered by a range of healthcare professionals, but there is limited empirical investigation with this group. To adapt BATD for depressed adolescents (Brief BA) and conduct a pilot study to assess feasibility, acceptability and clinical effectiveness. Twenty depressed adolescents referred to the local NHS Child and Adolescent Mental Health service (CAMHs) were offered eight sessions of Brief BA followed by a review around one month later. Self- and parent-reported routine outcome measures (ROMs) were collected at every session. Nineteen of the 20 young people fully engaged with the treatment and all reported finding some aspect of Brief BA helpful. Thirteen (65%) required no further psychological intervention following Brief BA, and both young people and parents reported high levels of acceptability and satisfaction with the approach. The pre-post effect size of Brief BA treatment was large. Brief BA is a promising innovation in the treatment of adolescent depression. This approach requires further evaluation to establish effectiveness and cost effectiveness compared with existing evidence-based treatments for adolescent depression. Other questions concern the effectiveness of delivery in other settings and when delivered by a range of professionals.

  8. Kawasaki disease: A brief history.

    PubMed

    Burns, J C; Kushner, H I; Bastian, J F; Shike, H; Shimizu, C; Matsubara, T; Turner, C L

    2000-08-01

    Tomisaku Kawasaki published the first English-language report of 50 patients with Kawasaki disease (KD) in 1974. Since that time, KD has become the leading cause of acquired heart disease among children in North America and Japan. Although an infectious agent is suspected, the cause remains unknown. However, significant progress has been made toward understanding the natural history of the disease and therapeutic interventions have been developed that halt the immune-mediated destruction of the arterial wall. We present a brief history of KD, review progress in research on the disease, and suggest avenues for future study. Kawasaki saw his first case of KD in January 1961 and published his first report in Japanese in 1967. Whether cases existed in Japan before that time is currently under study. The most significant controversy in the 1960s in Japan was whether the rash and fever sign/symptom complex described by Kawasaki was connected to subsequent cardiac complications in a number of cases. Pathologist Noboru Tanaka and pediatrician Takajiro Yamamoto disputed the early assertion of Kawasaki that KD was a self-limited illness with no sequelae. This controversy was resolved in 1970 when the first Japanese nationwide survey of KD documented 10 autopsy cases of sudden cardiac death after KD. By the time of the first English-language publication by Kawasaki in 1974, the link between KD and coronary artery vasculitis was well-established. KD was independently recognized as a new and distinct condition in the early 1970s by pediatricians Marian Melish and Raquel Hicks at the University of Hawaii. In 1973, at the same Hawaiian hospital, pathologist Eunice Larson, in consultation with Benjamin Landing at Los Angeles Children's Hospital, retrospectively diagnosed a 1971 autopsy case as KD. The similarity between KD and infantile periarteritis nodosa (IPN) was apparent to these pathologists, as it had been to Tanaka earlier. What remains unknown is the reason for the

  9. Observations of Infalling and Rotational Motions on a 1000 AU Scale around 17 Class 0 and 0/I Protostars: Hints of Disk Growth and Magnetic Braking?

    NASA Astrophysics Data System (ADS)

    Yen, Hsi-Wei; Koch, Patrick M.; Takakuwa, Shigehisa; Ho, Paul T. P.; Ohashi, Nagayoshi; Tang, Ya-Wen

    2015-02-01

    We perform imaging and analyses of SMA 1.3 mm continuum, C18O (2-1) and 12CO (2-1) line data of 17 Class 0 and 0/I protostars to study their gas kinematics on a 1000 AU scale. Continuum and C18O (2-1) emission are detected toward all the sample sources and show central primary components with sizes of ~600-1500 AU associated with protostars. The velocity gradients in C18O (2-1) have wide ranges of orientations from parallel to perpendicular to the outflows, with magnitudes from ~1 to ~530 km s-1 pc-1. We construct a simple kinematic model to reproduce the observed velocity gradients, estimate the infalling and rotational velocities, and infer the disk radii and the protostellar masses. The inferred disk radii range from <5 AU to >500 AU with estimated protostellar masses from <0.1 M ⊙ to >1 M ⊙. Our results hint that both large and small disks are possibly present around Class 0 protostars, which could be a sign of disk growth at the Class 0 stage. In addition, the directions of the overall velocity gradients in 7 out of the 17 sources are close to perpendicular to their outflow axes (Δθ > 65°), which is a signature of significant rotational motions. From our model fitting, the specific angular momenta in these sources are estimated to be >2 × 10-4 km s-1 pc, suggesting that magnetic braking is unlikely efficient on a 1000 AU scale in these Class 0 and 0/I sources. In a sub-sample with observed magnetic field orientations, we find no source with large specific angular momenta together with closely aligned magnetic field and outflow axes. This possibly hints that the magnetic field, if originally aligned with the rotational axis, can play a role in removing angular momentum from infalling material at the Class 0 stage. We discuss our results in comparison with theoretical models of collapsing dense cores with and without magnetic fields in the context of disk formation.

  10. OBSERVATIONS OF INFALLING AND ROTATIONAL MOTIONS ON A 1000 AU SCALE AROUND 17 CLASS 0 AND 0/I PROTOSTARS: HINTS OF DISK GROWTH AND MAGNETIC BRAKING?

    SciTech Connect

    Yen, Hsi-Wei; Koch, Patrick M.; Takakuwa, Shigehisa; Ho, Paul T. P.; Ohashi, Nagayoshi; Tang, Ya-Wen

    2015-02-01

    We perform imaging and analyses of SMA 1.3 mm continuum, C{sup 18}O (2-1) and {sup 12}CO (2-1) line data of 17 Class 0 and 0/I protostars to study their gas kinematics on a 1000 AU scale. Continuum and C{sup 18}O (2-1) emission are detected toward all the sample sources and show central primary components with sizes of ∼600-1500 AU associated with protostars. The velocity gradients in C{sup 18}O (2-1) have wide ranges of orientations from parallel to perpendicular to the outflows, with magnitudes from ∼1 to ∼530 km s{sup –1} pc{sup –1}. We construct a simple kinematic model to reproduce the observed velocity gradients, estimate the infalling and rotational velocities, and infer the disk radii and the protostellar masses. The inferred disk radii range from <5 AU to >500 AU with estimated protostellar masses from <0.1 M {sub ☉} to >1 M {sub ☉}. Our results hint that both large and small disks are possibly present around Class 0 protostars, which could be a sign of disk growth at the Class 0 stage. In addition, the directions of the overall velocity gradients in 7 out of the 17 sources are close to perpendicular to their outflow axes (Δθ > 65°), which is a signature of significant rotational motions. From our model fitting, the specific angular momenta in these sources are estimated to be >2 × 10{sup –4} km s{sup –1} pc, suggesting that magnetic braking is unlikely efficient on a 1000 AU scale in these Class 0 and 0/I sources. In a sub-sample with observed magnetic field orientations, we find no source with large specific angular momenta together with closely aligned magnetic field and outflow axes. This possibly hints that the magnetic field, if originally aligned with the rotational axis, can play a role in removing angular momentum from infalling material at the Class 0 stage. We discuss our results in comparison with theoretical models of collapsing dense cores with and without magnetic fields in the context of disk

  11. Screening and brief intervention for underage drinkers.

    PubMed

    Clark, Duncan B; Gordon, Adam J; Ettaro, Lorraine R; Owens, Jill M; Moss, Howard B

    2010-04-01

    In a 2007 report, the US Surgeon General called for health care professionals to renew efforts to reduce underage drinking. Focusing on the adolescent patient, this review provides health care professionals with recommendations for alcohol-related screening, brief intervention, and referral to treatment. MEDLINE and published reviews were used to identify relevant literature. Several brief screening methods have been shown to effectively identify underage drinkers likely to have alcohol use disorders. After diagnostic assessment when germane, the initial intervention typically focuses on education, motivation for change, and consideration of treatment options. Internet-accessible resources providing effective brief interventions are available, along with supplemental suggestions for parents. Recent changes in federal and commercial insurance reimbursement policies provide some fiscal support for these services, although rate increases and expanded applicability may be required to prompt the participation of many practitioners. Nevertheless, advances in clinical methods and progress on reimbursement policies have made screening and brief intervention for underage drinking more feasible in general health care practice.

  12. District Awards for Teacher Excellence: Research Brief

    ERIC Educational Resources Information Center

    National Center on Performance Incentives, 2010

    2010-01-01

    Since 2008 Texas's District Awards for Teacher Excellence (D.A.T.E.) program has provided grants to districts for the implementation of locally designed incentive pay plans. The 2010-11 school year is the third year of the D.A.T.E. incentive pay plans with approximately $197 million in annual state funding. This research brief summarizes the key…

  13. MFT Doctoral Dissertations: A Brief Report

    ERIC Educational Resources Information Center

    Morris, James

    2013-01-01

    This brief report responds to the relative dearth of information available about MFT doctoral dissertations. A preliminary analysis of one COAMFTE [Commission on Accreditation for Marriage and Family Therapy Education] program is detailed. Suggestions for future action are offered. (Contains 1 table.)

  14. Trouble Brewing in Orange County. Policy Brief

    ERIC Educational Resources Information Center

    Buck, Stuart

    2010-01-01

    Orange County will soon face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that Orange County faces a total $41.2 billion liability for retiree benefits that are underfunded--including $9.4 billion for the county pension system and an estimated…

  15. The Wage Gap: Briefing Paper #1.

    ERIC Educational Resources Information Center

    National Committee on Pay Equity, Washington, DC.

    Women have made slow, steady progress in the labor market since 1979, but the wage gap has not narrowed significantly. This briefing paper updates a September 1987 paper based on "Male-Female Differences in Work Experience, Occupations, and Earnings: 1984" (Current Population Reports, Household Economic Studies, Series P-70, No. 10, issued in…

  16. Are Our Schools Safe? AEL Policy Briefs.

    ERIC Educational Resources Information Center

    Ceperley, Patricia; Simon, Karen

    Because of continued concern about school violence, this policy brief examines the trends in school violence in the context of social violence, describes efforts to make schools safe, and reports efforts to curb violence in the four-state Appalachian region (Kentucky, Tennessee, Virginia, and West Virginia). Perceptions of the extent of school…

  17. The Internet and Careers Work. NICEC Briefing.

    ERIC Educational Resources Information Center

    Offer, Marcus; Watts, Tony

    This briefing reviews the state of the art in the application of the Internet in career guidance and counseling. It describes how the Internet works and the main services offered: electronic mail, newsgroups, the World Wide Web, file transfer, and intranets. A glossary is provided. The following current and potential uses are discussed: access to…

  18. Genre Identification of Very Brief Musical Excerpts

    ERIC Educational Resources Information Center

    Mace, Sandra T.; Wagoner, Cynthia L.; Teachout, David J.; Hodges, Donald A.

    2012-01-01

    The purpose of this study was to examine how well individuals were able to identify different music genres from very brief excerpts and whether musical training, gender and preference played a role in genre identification. Listeners were asked to identify genre from classical, jazz, country, metal, and rap/hip hop excerpts that were 125, 250, 500,…

  19. 17 CFR 171.25 - Appeal brief.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... appeal brief with the Proceedings Clerk within thirty days after service of the record by the National... case. The statement shall indicate briefly the nature of the case and include a full description of the... consideration of the appeal with appropriate citations to the record; (3) An argument. The argument...

  20. Educational Access in Bangladesh. Country Policy Brief

    ERIC Educational Resources Information Center

    Ahmed, Manzoor

    2008-01-01

    This Policy Brief describes and explains patterns of access to schooling in Bangladesh. It outlines types of educational provision and provides some basic statistics on access, vulnerability and exclusion, as well as insights into the characteristics of those denied access. It is based on findings from the "Country Analytic Review on Access…

  1. A BRIEF HINDI REFERENCE GRAMMAR. PRELIMINARY VERSION.

    ERIC Educational Resources Information Center

    GUMPERZ, JOHN J.; MISRA, VIDYA NIWAS

    THIS BRIEF OUTLINE OF HINDI PHONOLOGY AND GRAMMAR IS INTENDED FOR FIRST AND SECOND YEAR STUDENTS OF HINDI WHO HAVE SOME PREVIOUS KNOWLEDGE OF THE ORAL AND WRITTEN LANGUAGE BUT WHO MAY HAVE HAD NO PREVIOUS TRAINING IN LINGUISTIC TERMINOLOGY. THE AUTHORS HAVE THEREFORE EMPHASIZED SIMPLICITY AND READABILITY RATHER THAN EXHAUSTIVENESS OR ORIGINALITY…

  2. ADHD--Building Academic Success. Policy Briefs.

    ERIC Educational Resources Information Center

    Gregg, Soleil

    This policy brief discusses students with attention deficit hyperactivity disorder (ADHD) and their school performance. Reasons are presented to explain why children with ADHD fail. The three main characteristics of ADHD (inattention, impulsivity, and hyperactivity) and their interference with academic performance are discussed. The brief…

  3. Partnerships: Sharing Responsibility for Children. Policy Briefs.

    ERIC Educational Resources Information Center

    Gregg, Soleil

    Because increasing numbers of children come to school with problems caused by poverty, divorce, drug use, and teenage pregnancy, schools may no longer be able to limit themselves solely to academic roles. This brief argues that schools, families, and communities need to work together to help children overcome the challenges that they face. It also…

  4. Briefing Teams in World Affairs Class.

    ERIC Educational Resources Information Center

    Dunn, Joe P.

    1992-01-01

    In a college world affairs course, the teacher acted as foreign policy/national security advisor to the president and assigned students as staff members for different geographic regions. Students briefed him daily, first on current events, then on specific issues. Students enjoyed the challenging assignments, intensive questioning, and policy…

  5. Universities and Development: Global Cooperation. Policy Briefing

    ERIC Educational Resources Information Center

    Universities UK, 2010

    2010-01-01

    This policy briefing aims to demonstrate that universities are key organisations in international development. Universities are involved in a wide range of international development activities, including collaborative research projects, developing entrepreneurial and employability skills and the evaluation of non-governmental organisation (NGO)…

  6. Brief to the Committee on University Affairs.

    ERIC Educational Resources Information Center

    Committee of Presidents of Universities of Ontario, Toronto.

    This document contains a brief on operating grants for the purpose of communicating system estimates of future university operating needs in Ontario universities to the Committee on University Affairs. Section II traces briefly the major financial developments of the past decade and the third section contains some impressions on the impacts of the…

  7. Improving Accountability in Public Education. Policy Brief

    ERIC Educational Resources Information Center

    Stecher, Brian; Li, Jennifer

    2009-01-01

    This is one in a series of policy briefs on key education issues prepared by the RAND Corporation for the Obama administration. The accountability systems put in place by No Child Left Behind have not produced enough improvement to meet the goal of all students meeting proficiency standards by 2014. While the current accountability system has…

  8. Quality Physical Education. NASPE Resource Brief

    ERIC Educational Resources Information Center

    National Association for Sport and Physical Education, 2013

    2013-01-01

    A quality physical education program provides learning opportunities, appropriate instruction, meaningful and challenging content, and student and program assessment. In addition, a quality physical education improves mental alertness, academic performance, and readiness and enthusiasm for learning in the nation's youth. This brief provides a list…

  9. Valentine's Day: a Brief History and Game

    ERIC Educational Resources Information Center

    Maxwell, D. Jackson

    2009-01-01

    Valentine's Day presents an opportunity to show loved ones they are appreciated. Sweethearts, spouses, and families exchange gifts to express affection. Beyond traditional celebrations, new customs such as a romantic dinner, attending movies, and exchanging jewelry have been added. This article presents a brief history of Valentine's Day and a…

  10. Counseling Services and Student Success. Research Brief

    ERIC Educational Resources Information Center

    Francis, Perry C.; Horn, Aaron S.

    2016-01-01

    The purpose of this research brief is to provide an overview of mental health issues and counseling services on college campuses. The findings from several national surveys are reviewed to estimate the prevalence of anxiety and depression, suicide and suicidal ideation, and violence among college students. Common prevention and treatment programs…

  11. A BRIEF ORAL OVERVIEW OF ENVIRONMENTAL ECONOMICS

    EPA Science Inventory

    A brief 1 hour oral presentation to professional staff of Cincinnati Nature Center is intended to provide a lay audience with a general understanding of how market-based approaches to environmental protection can meet (or exceed) regulatory efforts at enforcing pollution standard...

  12. Improving Accountability in Public Education. Policy Brief

    ERIC Educational Resources Information Center

    Stecher, Brian; Li, Jennifer

    2009-01-01

    This is one in a series of policy briefs on key education issues prepared by the RAND Corporation for the Obama administration. The accountability systems put in place by No Child Left Behind have not produced enough improvement to meet the goal of all students meeting proficiency standards by 2014. While the current accountability system has…

  13. Safe and Participatory Public Schools. Research Brief

    ERIC Educational Resources Information Center

    Rogers, John

    2010-01-01

    The California State Assembly is presently considering AB 2034 which would prohibit school districts, county offices of education (COEs), or charter schools that elect to fingerprint volunteers from allowing individuals who have been convicted of specific sex, drug or violent offenses to volunteer in schools. This policy brief aims to inform…

  14. Special Education: Migrant Education Policy Brief.

    ERIC Educational Resources Information Center

    Interstate Migrant Education Council, Washington, DC.

    This brief aims to alert educators to the special education needs of migrant children with disabilities. In 1991, the Migrant Student Record Transfer System (MSRTS) identified 711,696 migrant children, ages 0-21. The "at-risk" characteristics of the migrant family's health, working, and living conditions suggest that a representative number of…

  15. Greenhouse Gas Monitoring Technologies Technology Brief

    EPA Science Inventory

    This is a Technology Brief for the ETV Program. The EPA Environmental Technology Verification Program (ETV) develops test protocols and verifies the performance of innovative technologies that have the potential to improve protection of human health and the environment. The progr...

  16. Promoting Effective Preschool Programs. Policy Brief

    ERIC Educational Resources Information Center

    Karoly, Lynn; Zellman, Gail; Li, Jennifer

    2009-01-01

    This is one in a series of policy briefs on key education issues prepared by the RAND Corporation for the Obama administration. Preschool education plays an important role in increasing school readiness and closing achievement gaps for children at risk. However, access to high-quality preschool programs varies greatly. Therefore, policymakers…

  17. 37 CFR 41.37 - Appeal brief.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... convenience of the user, the revised text is set forth as follows: § 41.37 Appeal brief. (a) Requirement for... containing a claims section (see paragraph (p) of this section), a claim support and drawing analysis section (see paragraph (r) of this section), a means or step plus function analysis section (see paragraph...

  18. Grammar Schools: Brief Flowering of Social Mobility?

    ERIC Educational Resources Information Center

    Barker, Bernard

    2012-01-01

    Grammar schools are increasingly remembered, especially by right-wing ideologues, as the agents of a "brief flowering" of post-war social mobility. This article presents statistical, documentary and interview evidence of secondary education in the eleven plus era, and finds nothing to justify the claim that selective schools produced a general…

  19. Valentine's Day: a Brief History and Game

    ERIC Educational Resources Information Center

    Maxwell, D. Jackson

    2009-01-01

    Valentine's Day presents an opportunity to show loved ones they are appreciated. Sweethearts, spouses, and families exchange gifts to express affection. Beyond traditional celebrations, new customs such as a romantic dinner, attending movies, and exchanging jewelry have been added. This article presents a brief history of Valentine's Day and a…

  20. 45 CFR 213.31 - Posthearing briefs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Posthearing briefs. 213.31 Section 213.31 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES PRACTICE AND PROCEDURE...

  1. 45 CFR 213.31 - Posthearing briefs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Posthearing briefs. 213.31 Section 213.31 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES PRACTICE AND PROCEDURE...

  2. 45 CFR 1386.110 - Posthearing briefs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Posthearing briefs. 1386.110 Section 1386.110 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON DEVELOPMENTAL DISABILITIES,...

  3. 45 CFR 1386.110 - Posthearing briefs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Posthearing briefs. 1386.110 Section 1386.110 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON DEVELOPMENTAL DISABILITIES,...

  4. 39 CFR 3001.34 - Briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Briefs. 3001.34 Section 3001.34 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL RULES OF PRACTICE AND PROCEDURE Rules of General Applicability... regard to the timely issuance of a recommended decision or advisory opinion to the Postal Service within...

  5. District Awards for Teacher Excellence: Research Brief

    ERIC Educational Resources Information Center

    National Center on Performance Incentives, 2010

    2010-01-01

    Since 2008 Texas's District Awards for Teacher Excellence (D.A.T.E.) program has provided grants to districts for the implementation of locally designed incentive pay plans. The 2010-11 school year is the third year of the D.A.T.E. incentive pay plans with approximately $197 million in annual state funding. This research brief summarizes the key…

  6. MFT Doctoral Dissertations: A Brief Report

    ERIC Educational Resources Information Center

    Morris, James

    2013-01-01

    This brief report responds to the relative dearth of information available about MFT doctoral dissertations. A preliminary analysis of one COAMFTE [Commission on Accreditation for Marriage and Family Therapy Education] program is detailed. Suggestions for future action are offered. (Contains 1 table.)

  7. Educational Access in Ghana. Country Policy Brief

    ERIC Educational Resources Information Center

    Akyeampong, K.; Djangmah, J.; Oduro, A.; Seidu, A.; Hunt, F.

    2008-01-01

    This Policy Brief describes and explains patterns of access to schools in Ghana. It outlines policy and legislation on access to education and provides an analysis of access, vulnerability and exclusion. It is based on findings from the Country Analytic Report on Access to Basic Education in Ghana (Akyeampong et al, 2007) [ED508809] which can be…

  8. Economic Education in Malaysia: A Brief Report.

    ERIC Educational Resources Information Center

    Rao, C. A.

    1978-01-01

    This report provides a brief description of economic education in Malaysia and indicates interest, on the part of various Asian countries, i.e., Malaysia, Singapore, Indonesia, Thailand, and the Philippines, in the establishment of economic education programs. (Editor/RK)

  9. Early Learning and Educational Technology Policy Brief

    ERIC Educational Resources Information Center

    Lee, Joan

    2016-01-01

    Recognizing the growth of technology use in early learning settings, the U.S. Department of Education and U.S. Department of Health and Human Services collaborated in the development of the "Early Learning and Educational Technology Policy Brief" to promote developmentally appropriate use of technology in homes and early learning…

  10. Teacher Retirement Systems: Research Findings. Research Brief

    ERIC Educational Resources Information Center

    Hansen, Janet S.; Podgursky, Michael J.; Costrell, Robert M.

    2009-01-01

    This policy brief summarizes findings presented at a February 2009 research conference on teacher retirement systems hosted by the National Center on Performance Incentives (NCPI) at Vanderbilt University's Peabody College. The 2009 conference was the second in a series of NCPI events focusing on findings from recent research on issues related to…

  11. Trouble Brewing in Los Angeles. Policy Brief

    ERIC Educational Resources Information Center

    Buck, Stuart

    2010-01-01

    The city of Los Angeles will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that Los Angeles faces a total $152.6 billion liability for pensions that are underfunded--including $49.1 billion for the city pension systems, $2.4 billion for…

  12. Trouble Brewing in San Francisco. Policy Brief

    ERIC Educational Resources Information Center

    Buck, Stuart

    2010-01-01

    The city of San Francisco will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that San Francisco faces an aggregate $22.4 billion liability for pensions and retiree health benefits that are underfunded--including $14.1 billion for the city…

  13. Rhode Island KIDS COUNT Issue Brief, 1996.

    ERIC Educational Resources Information Center

    Bryant, Elizabeth Burke, Ed.; Walsh, Catherine Boisvert, Ed.

    1996-01-01

    These two Kids Count brief reports discuss issues related to the well-being of Rhode Island children. The first report identifies ways to measure the impact of state and federal welfare reform proposals on children who receive benefits through Aid to Families with Dependent Children (AFDC). Potential measures of success for welfare reform include…

  14. CTE's Role in Urban Education. Issue Brief

    ERIC Educational Resources Information Center

    Association for Career and Technical Education (ACTE), 2012

    2012-01-01

    This Issue Brief explores the promising role that career and technical education programs play in addressing key student achievement issues facing urban schools. CTE programs engage urban students by providing rigorous and relevant coursework, fostering positive relationships, establishing clear pathways and connecting education and…

  15. A BRIEF ORAL OVERVIEW OF ENVIRONMENTAL ECONOMICS

    EPA Science Inventory

    A brief 1 hour oral presentation to professional staff of Cincinnati Nature Center is intended to provide a lay audience with a general understanding of how market-based approaches to environmental protection can meet (or exceed) regulatory efforts at enforcing pollution standard...

  16. Economic Education in Malaysia: A Brief Report.

    ERIC Educational Resources Information Center

    Rao, C. A.

    1978-01-01

    This report provides a brief description of economic education in Malaysia and indicates interest, on the part of various Asian countries, i.e., Malaysia, Singapore, Indonesia, Thailand, and the Philippines, in the establishment of economic education programs. (Editor/RK)

  17. NASA Ames Fluid Mechanics Laboratory research briefs

    NASA Technical Reports Server (NTRS)

    Davis, Sanford (Editor)

    1994-01-01

    The Ames Fluid Mechanics Laboratory research program is presented in a series of research briefs. Nineteen projects covering aeronautical fluid mechanics and related areas are discussed and augmented with the publication and presentation output of the Branch for the period 1990-1993.

  18. Grammar Schools: Brief Flowering of Social Mobility?

    ERIC Educational Resources Information Center

    Barker, Bernard

    2012-01-01

    Grammar schools are increasingly remembered, especially by right-wing ideologues, as the agents of a "brief flowering" of post-war social mobility. This article presents statistical, documentary and interview evidence of secondary education in the eleven plus era, and finds nothing to justify the claim that selective schools produced a general…

  19. 19 CFR 207.25 - Posthearing briefs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Posthearing briefs. 207.25 Section 207.25 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  20. 19 CFR 207.65 - Prehearing briefs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Prehearing briefs. 207.65 Section 207.65 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  1. 19 CFR 207.65 - Prehearing briefs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Prehearing briefs. 207.65 Section 207.65 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  2. 19 CFR 207.23 - Prehearing brief.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Prehearing brief. 207.23 Section 207.23 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  3. 19 CFR 207.65 - Prehearing briefs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Prehearing briefs. 207.65 Section 207.65 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  4. 19 CFR 207.23 - Prehearing brief.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Prehearing brief. 207.23 Section 207.23 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  5. 19 CFR 207.65 - Prehearing briefs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Prehearing briefs. 207.65 Section 207.65 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  6. 19 CFR 207.23 - Prehearing brief.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Prehearing brief. 207.23 Section 207.23 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  7. 19 CFR 207.25 - Posthearing briefs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Posthearing briefs. 207.25 Section 207.25 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  8. 19 CFR 207.25 - Posthearing briefs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Posthearing briefs. 207.25 Section 207.25 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  9. 19 CFR 207.25 - Posthearing briefs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Posthearing briefs. 207.25 Section 207.25 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  10. 19 CFR 207.23 - Prehearing brief.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Prehearing brief. 207.23 Section 207.23 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

  11. [Solution focused brief therapy in psychiatric practice].

    PubMed

    Bakker, J M; Bannink, F P

    2008-01-01

    Solution focused brief therapy (SFBT) is a form of psychotherapy that reinforces clients' strengths and focuses on what clients want to replace their problems with. Research shows that SFBT is beneficial and cost-effective and makes the psychiatrist's work more satisfying. It can be used as primary psychotherapy, for instance during crisis intervention, or even as an addition to pharmacotherapy.

  12. Competency-Based Business Degree. Issue Brief

    ERIC Educational Resources Information Center

    Washington State Board for Community and Technical Colleges, 2014

    2014-01-01

    In January 2015, thirteen Washington community colleges launched an online, competency-based business transfer degree--the first in the state's community and technical college system. This issue brief provides answers to commonly asked questions about the new competency-based degree.

  13. 37 CFR 41.68 - Respondent's brief.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... respondent does not file an amended respondent brief within the set time period, or files an amended.... (a)(1) Respondent(s) in an appeal may once, within the time limit for filing set forth in § 41.66... must be specified with particularity. (v) Summary of claimed subject matter. A statement accepting...

  14. OSIRIS-REx Mission Science Briefing

    NASA Image and Video Library

    2016-09-06

    In the Kennedy Space Center’s Press Site auditorium, Christina Richey, OSIRIS-REx deputy program scientist at NASA Headquarters in Washington, speaks to members of the media during a briefing on science experiments involved in NASA’s Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer, or OSIRIS-REx spacecraft.

  15. OSIRIS-REx Mission Science Briefing

    NASA Image and Video Library

    2016-09-06

    In the Kennedy Space Center’s Press Site auditorium, Nancy Neal-Jones of NASA Communications at the Goddard Space Flight Center in Greenbelt, Maryland, moderates a media briefing on science experiments involved in NASA’s Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer, or OSIRIS-REx spacecraft.

  16. OSIRIS-REx Mission Science Briefing

    NASA Image and Video Library

    2016-09-06

    In the Kennedy Space Center’s Press Site auditorium, Daniella DellaGiustina, OSIRIS-REx lead image processing scientist at the University of Arizona, Tucson, speaks to members of the media during a briefing on science experiments involved in NASA’s Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer, or OSIRIS-REx spacecraft.

  17. Genre Identification of Very Brief Musical Excerpts

    ERIC Educational Resources Information Center

    Mace, Sandra T.; Wagoner, Cynthia L.; Teachout, David J.; Hodges, Donald A.

    2012-01-01

    The purpose of this study was to examine how well individuals were able to identify different music genres from very brief excerpts and whether musical training, gender and preference played a role in genre identification. Listeners were asked to identify genre from classical, jazz, country, metal, and rap/hip hop excerpts that were 125, 250, 500,…

  18. 19 CFR 207.23 - Prehearing brief.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Prehearing brief. 207.23 Section 207.23 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM SUBSIDIZED...

  19. 19 CFR 207.65 - Prehearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Prehearing briefs. 207.65 Section 207.65 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM SUBSIDIZED...

  20. 19 CFR 207.25 - Posthearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Posthearing briefs. 207.25 Section 207.25 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM SUBSIDIZED...