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Sample records for 4d planck mass

  1. Localizability and the planck mass

    SciTech Connect

    Ne`eman, Y. |

    1993-06-01

    The author combines the assumption of environmental decoherence, as the mechanism generating the classical (i.e. no quantum interferences) nature of spacetime, with the limit on its other classical feature, point-like continuity, namely Planck length. As a result, quantum extended objects with masses larger than Planck mass have to derive their quantum behavior from long-range correlations; objects with masses smaller than Planck mass cannot display classical behavior.

  2. Observational effects of a running Planck mass

    NASA Astrophysics Data System (ADS)

    Huang, Zhiqi

    2016-02-01

    We consider observational effects of a running effective Planck mass in the scalar-tensor gravity theory. At the background level, an increasing effective Planck mass allows a larger Hubble constant H0, which is more compatible with the local direct measurements. At the perturbative level, for cosmic microwave background (CMB) anisotropies, an increasing effective Planck mass (i) suppresses the unlensed CMB power at ℓ≲30 via the integrated Sachs-Wolfe effect and (ii) enhances CMB lensing power. Both effects slightly relax the tension between the current CMB data from the Planck satellite and the standard Λ CDM model predictions. However, these impacts on the CMB secondary anisotropies are subdominant, and the overall constraints are driven by the background measurements. Combining CMB data from the Planck satellite and an H0 prior from Riess et al., we find a ˜2 σ hint of a positive running of the effective Planck mass. However, the hint goes away when we add other low-redshift observational data including type Ia supernovae, baryon acoustic oscillations, and an estimation of the age of the Universe using the old stars.

  3. Planck-scale physics and neutrino masses

    NASA Astrophysics Data System (ADS)

    Akhmedov, Evgenii Kh.; Berezhiani, Zurab G.; Senjanovic, Goran

    1992-11-01

    We discuss gravitationally induced masses and mass splittings of Majorana, Zeldovich-Konopinski-Mahmoud, and Dirac neutrinos. Among other implications, these effects can provide a solution of the solar neutrino puzzle. In particular, we show how this may work in the 17 keV neutrino picture.

  4. Magnetic mass in 4D AdS gravity

    NASA Astrophysics Data System (ADS)

    Araneda, René; Aros, Rodrigo; Miskovic, Olivera; Olea, Rodrigo

    2016-04-01

    We provide a fully covariant expression for the diffeomorphic charge in four-dimensional anti-de Sitter gravity, when the Gauss-Bonnet and Pontryagin terms are added to the action. The couplings of these topological invariants are such that the Weyl tensor and its dual appear in the on-shell variation of the action and such that the action is stationary for asymptotic (anti-)self-dual solutions in the Weyl tensor. In analogy with Euclidean electromagnetism, whenever the self-duality condition is global, both the action and the total charge are identically vanishing. Therefore, for such configurations, the magnetic mass equals the Ashtekhar-Magnon-Das definition.

  5. The important role of evolution in the Planck YSZ-mass calibration

    NASA Astrophysics Data System (ADS)

    Andreon, S.

    2014-10-01

    In light of the tension between cosmological parameters from Planck cosmic microwave background and galaxy clusters, we revised the Planck analysis of the YSZ-mass calibration to allow evolution to be determined by the data instead of being imposed as an external constraint. Our analysis uses the very same data and Malmquist bias corrections as used by the Planck team in order to emphasize that differences in the results come from differences in the assumptions. The evolution derived from 71 calibrating clusters, with 0.05 < z < 0.45, is proportional to E2.5 ± 0.4(z), so inconsistent with the self-similar evolution (E2/3) assumed by previous analyses. When allowing for evolution, the slope of YSZ-mass relation turns out to be 1.51 ± 0.07, which is shallower by 4.8σ than the value derived when assuming self-similar evolution, introducing a mass-dependent bias. The non-self-similar evolution of YSZ has to be accounted for in analyses aimed to establish the biases of Planck masses.

  6. Mass hierarchies from anomalies: A peek behind the Planck curtain

    SciTech Connect

    Ramond, P.

    1996-05-01

    The masses of quarks and leptons suggest a strong hierarchical structure. We argue that their patterns can be reproduced through the introduction of a new Abelian symmetry. The data suggest that this symmetry is anomalous. We suggest that the cancellation of its anomalies occurs through the Green-Schwarz mechanism. An important check of this idea is that it links the Weinberg angle to a mass ration of the elementary fermions. The Green-Schwarz mechanism occurs naturally in many superstring compactifications, and produces a small parameter, which we use to determine the quark mass hierarchy. We show that hierarchy and mixings among the chiral fermions is a consequence of the Green-Schwarz mechanism. We present several models where this idea is realized. 16 refs., 2 tabs.

  7. Cosmological axion and neutrino mass constraints from Planck 2015 temperature and polarization data

    NASA Astrophysics Data System (ADS)

    Di Valentino, Eleonora; Giusarma, Elena; Lattanzi, Massimiliano; Mena, Olga; Melchiorri, Alessandro; Silk, Joseph

    2016-01-01

    Axions currently provide the most compelling solution to the strong CP problem. These particles may be copiously produced in the early universe, including via thermal processes. Therefore, relic axions constitute a hot dark matter component and their masses are strongly degenerate with those of the three active neutrinos, as they leave identical signatures in the different cosmological observables. In addition, thermal axions, while still relativistic states, also contribute to the relativistic degrees of freedom, parameterized via Neff. We present the cosmological bounds on the relic axion and neutrino masses, exploiting the full Planck mission data, which include polarization measurements. In the mixed hot dark matter scenario explored here, we find the tightest and more robust constraint to date on the sum of the three active neutrino masses, ∑mν < 0.136 eV at 95% CL, as it is obtained in the very well-known linear perturbation regime. The Planck Sunyaev-Zeldovich cluster number count data further tightens this bound, providing a 95% CL upper limit of ∑mν < 0.126 eV in this very same mixed hot dark matter model, a value which is very close to the expectations in the inverted hierarchical neutrino mass scenario. Using this same combination of data sets we find the most stringent bound to date on the thermal axion mass, ma < 0.529 eV at 95% CL.

  8. Demokrit - Planck

    NASA Astrophysics Data System (ADS)

    Rompe, Robert; Treder, Hans-Jürgen

    Es gibt eine Physik, die an die Konstante h gebunden ist und die mit der Atomistik zusammenhängt. Diese h-Physik geht eindeutig auf Planck zurück. Aber, aus dieser Physik folgt die Atomistik als Existenz lokalisierter geladener Teilchen unterschiedlichen Massen nicht, vor allem nicht die des Ladungsquants, so daß also Demokrit mehr behauptet hat, als die Quantenphysik zu beantworten kompetent ist.Translated AbstractDemokrit - PlanckA branch of physics exists closely linked to the constant h and associated with atomism. It is this h-physics that Planck originated. But atomism like existence of localized, charged particles with different masses does not follow from this physics, especially the charge quant. Hence Demokrit asserted more then quantum physics is competent to answer.

  9. Regional water-quality analysis of 2,4-D and dicamba in river water using gas chromatography-isotope dilution mass spectrometry

    USGS Publications Warehouse

    Thurman, E.M.; Zimmerman, L.R.; Aga, D.S.; Gilliom, R.J.

    2001-01-01

    Gas chromatography with isotope dilution mass spectrometry (GC-MS) and enzyme-linked immunosorbent assay (ELISA) were used in regional National Water Quality Assessment studies of the herbicides, 2,4-D and dicamba, in river water across the United States. The GC-MS method involved solid-phase extraction, derivatized with deutemted 2,4-D, and analysis by selected ion monitoring. The ELISA method was applied after preconcentration with solid-phase extraction. The ELISA method was unreliable because of interference from humic substances that were also isolated by solid-phase extraction. Therefore, GC-MS was used to analyzed 80 samples from river water from 14 basins. The frequency of detection of dicamba (28%) was higher than that for 2,4-D (16%). Concentrations were higher for dicamba than for 2,4-D, ranging from less than the detection limit (<0.05 ??g/L) to 3.77 ??g/L, in spite of 5 times more annual use of 2,4-D as compared to dicamba. These results suggest that 2,4-D degrades more rapidly in the environment than dicamba.

  10. Planck stars

    NASA Astrophysics Data System (ADS)

    Rovelli, Carlo; Vidotto, Francesca

    2014-12-01

    Quantum-gravitational pressure can stop gravitational collapse and cause a bounce. We observe that: (i) due to the huge time dilation, the process can last micro-seconds in local proper time and billions of years observed from the outside; (ii) the bounce volume can be much larger than planckian, because the onset of quantum-gravity effects is governed by density, not size; (iii) the emerging object can then be bigger than planckian by a factor (m/mP)n, where m is the initial mass, mP is the Planck mass, and n positive; (iv) the interior of an evaporating hole can keep memory of the initial mass, providing an independent scale for the physics of the final explosion. If so, primordial black holes could produce a detectable signal of quantum gravitational origin, which we estimate, under some hypotheses, around the wavelength 10-14 cm.

  11. An adaptive, conservative 0D-2V multispecies Rosenbluth-Fokker-Planck solver for arbitrarily disparate mass and temperature regimes

    NASA Astrophysics Data System (ADS)

    Taitano, W. T.; Chacón, L.; Simakov, A. N.

    2016-08-01

    In this study, we propose an adaptive velocity-space discretization scheme for the multi-species, multidimensional Rosenbluth-Fokker-Planck (RFP) equation, which is exactly mass-, momentum-, and energy-conserving. Unlike most earlier studies, our approach normalizes the velocity-space coordinate to the temporally varying individual plasma species' local thermal velocity, vth (t), and explicitly considers the resulting inertial terms in the Fokker-Planck equation. Our conservation strategy employs nonlinear constraints to enforce discretely the conservation properties of these inertial terms and the Fokker-Planck collision operator. To deal with situations of extreme thermal velocity disparities among different species, we employ an asymptotic vth-ratio-based expansion of the Rosenbluth potentials that only requires the computation of several velocity-space integrals. Numerical examples demonstrate the favorable efficiency and accuracy properties of the scheme. In particular, we show that the combined use of the velocity-grid adaptivity and asymptotic expansions delivers many orders-of-magnitude savings in mesh resolution requirements compared to a single, static uniform mesh.

  12. Planck 2010

    SciTech Connect

    2010-06-02

    Planck 2010 From the Planck Scale to the ElectroWeak Scale The conference will be the twelfth one in a series of meetings on physics beyond the Standard Model, organized jointly by several European groups: Bonn, CERN, Ecole Polytechnique, ICTP, Madrid, Oxford, Padua, Pisa, SISSA and Warsaw as part of activities in the framework of the European network UNILHC.Topics to be discussed: Supersymmetry Supergravity & string phenomenology Extra dimensions Electroweak symmetry breaking LHC and Tevatron Physics Collider physics Flavor & neutrinos physics Astroparticle & cosmology Gravity & holography Strongly coupled physics & CFT Registration: registration will be open until May 1st. Registration fees amount to 150 CHF and cover the cost of the coffee breaks and the social dinner. Payment has to be made online. The deadline for registration has been postponed to May 7th. However, after May 3th, we shall not accept any talk request any more. The meeting will be partly supported by ° the Marie Curie Initial Training Network "UNILHC" PITN-GA-2009-23792, ° the ERC Advanced Grant "MassTeV" 226371, ° and the CERN-TH unit.

  13. Planck 2010

    ScienceCinema

    None

    2016-07-12

    Planck 2010 From the Planck Scale to the ElectroWeak Scale The conference will be the twelfth one in a series of meetings on physics beyond the Standard Model, organized jointly by several European groups: Bonn, CERN, Ecole Polytechnique, ICTP, Madrid, Oxford, Padua, Pisa, SISSA and Warsaw as part of activities in the framework of the European network UNILHC.Topics to be discussed: Supersymmetry Supergravity & string phenomenology Extra dimensions Electroweak symmetry breaking LHC and Tevatron Physics Collider physics Flavor & neutrinos physics Astroparticle & cosmology Gravity & holography Strongly coupled physics & CFT Registration: registration will be open until May 1st. Registration fees amount to 150 CHF and cover the cost of the coffee breaks and the social dinner. Payment has to be made online. The deadline for registration has been postponed to May 7th. However, after May 3th, we shall not accept any talk request any more. The meeting will be partly supported by ° the Marie Curie Initial Training Network "UNILHC" PITN-GA-2009-23792, ° the ERC Advanced Grant "MassTeV" 226371, ° and the CERN-TH unit.

  14. Updated measurements of the dark matter halo masses of obscured quasars with improved WISE and Planck data

    NASA Astrophysics Data System (ADS)

    DiPompeo, M. A.; Hickox, R. C.; Myers, A. D.

    2016-02-01

    Using the most recent releases of WISE and Planck data, we perform updated measurements of the bias and typical dark matter halo mass of infrared (IR)-selected obscured and unobscured quasars, using the angular autocorrelation function and cosmic microwave background lensing cross-correlations. Since our recent work of this kind, the WISE ALLWISE catalogue was released with improved photometry, and the Planck mission was completed and released improved products. These new data provide a more reliable measurement of the quasar bias and provide an opportunity to explore the role of changing survey pipelines in results downstream. We present a comparison of IR colour-selected quasars, split into obscured and unobscured populations based on optical-IR colours, selected from two versions of the WISE data. Which combination of data is used impacts the final results, particularly for obscured quasars, both because of mitigation of some systematics and because the newer catalogue provides a slightly different sample. We show that ALLWISE data is superior in several ways, though there may be some systematic trends with Moon contamination that were not present in the previous catalogue. We opt currently for the most conservative sample that meet our selection criteria in both the previous and new WISE catalogues. We measure a higher bias and halo mass for obscured quasars (bobsc ˜ 2.1, bunob ˜ 1.8) - at odds with simple orientation models - but at a reduced significance (˜1.5σ) as compared to our work with previous survey data.

  15. Evaluation of mass balance, 4D-Var, and hybrid approaches to constraining NOx emissions using OMI NO2 remote sensing measurements.

    NASA Astrophysics Data System (ADS)

    Qu, Z.

    2015-12-01

    Nitrogen oxides (NOx) contribute to photochemical smog, tropospheric ozone and aerosol, and human health problems. Remote sensing observations provide a valuable means of constraining emissions of NOx, and thus improving our ability to use air quality models for further understanding these issues. Traditional top-down estimates have provided important constraints for NOx emission inventories in China, but are either time-consuming (e.g., 4D-Var) or only crudely represent the influence of atmospheric transport and chemistry (e.g., mass balance). Here, we combine mass balance and 4D-Var approaches, and investigate the improvements in simulated NOx column density over China. Scaling factors derived from the mass balance approach with OMI observations are first applied to NOx emissions. In this process, a smoothing kernel is used to account for emissions from adjacent grid cells, and optimized NOx emissions are derived using maximum likelihood estimation, which weigh top-down and bottom up estimates by their relative errors. This is followed by subsequent inversion using an adjoint-based 4D-Var approach with GEOS-Chem at the 0.5x0.667 degree resolution. We consider the correlations between errors in neighboring grid cells by using off-diagonal terms in scaling factors' error covariance matrix. An optimal value of the regularization parameter is selected using an L-curve and minimization of total error. We compare the solutions obtained using this hybrid approach with that obtained from standard 4D-Var, as well as to the direct solution from the mass balance approach itself. Differences between these methods in specific grid cells are investigated. We demonstrate the effect of transport and chemistry on the performance of mass balance and 4D-Var, identifying cases where the smoothing kernel and weighting errors in mass balance can cause the scaling factor to be in a direction that occasionally increases residual error. This study shows potential to facilitate decadal

  16. Assessment of the Precision and Reproducibility of Ventricular Volume, Function and Mass Measurements with Ferumoxytol-Enhanced 4D Flow MRI

    PubMed Central

    Hanneman, Kate; Kino, Aya; Cheng, Joseph Y; Alley, Marcus T; Vasanawala, Shreyas S

    2016-01-01

    Purpose To compare the precision and inter-observer agreement of ventricular volume, function and mass quantification by three-dimensional time-resolved (4D) flow MRI relative to cine steady state free precession (SSFP). Materials and Methods With research board approval, informed consent, and HIPAA compliance, 22 consecutive patients with congenital heart disease (CHD) (10 males, 6.4±4.8 years) referred for 3T ferumoxytol-enhanced cardiac MRI were prospectively recruited. Complete ventricular coverage with standard 2D short-axis cine SSFP and whole chest coverage with axial 4D flow were obtained. Two blinded radiologists independently segmented images for left ventricular (LV) and right ventricular (RV) myocardium at end systole (ES) and end diastole (ED). Statistical analysis included linear regression, ANOVA, Bland-Altman (BA) analysis, and intra-class correlation (ICC). Results Significant positive correlations were found between 4D flow and SSFP for ventricular volumes (r = 0.808–0.972, p<0.001), ejection fraction (EF) (r = 0.900–928, p<0.001), and mass (r = 0.884–0.934, p<0.001). BA relative limits of agreement for both ventricles were between −52% to 34% for volumes, −29% to 27% for EF, and −41% to 48% for mass, with wider limits of agreement for the RV compared to the LV. There was no significant difference between techniques with respect to mean square difference of ED-ES mass for either LV (F=2.05, p=0.159) or RV (F=0.625, p=0.434). Inter-observer agreement was moderate to good with both 4D flow (ICC 0.523–0.993) and SSFP (ICC 0.619–0.982), with overlapping confidence intervals. Conclusion Quantification of ventricular volume, function and mass can be accomplished with 4D flow MRI with precision and inter-observer agreement comparable to that of cine SSFP. PMID:26871420

  17. Direct dose mapping versus energy/mass transfer mapping for 4D dose accumulation: fundamental differences and dosimetric consequences

    NASA Astrophysics Data System (ADS)

    Li, Haisen S.; Zhong, Hualiang; Kim, Jinkoo; Glide-Hurst, Carri; Gulam, Misbah; Nurushev, Teamour S.; Chetty, Indrin J.

    2014-01-01

    The direct dose mapping (DDM) and energy/mass transfer (EMT) mapping are two essential algorithms for accumulating the dose from different anatomic phases to the reference phase when there is organ motion or tumor/tissue deformation during the delivery of radiation therapy. DDM is based on interpolation of the dose values from one dose grid to another and thus lacks rigor in defining the dose when there are multiple dose values mapped to one dose voxel in the reference phase due to tissue/tumor deformation. On the other hand, EMT counts the total energy and mass transferred to each voxel in the reference phase and calculates the dose by dividing the energy by mass. Therefore it is based on fundamentally sound physics principles. In this study, we implemented the two algorithms and integrated them within the Eclipse treatment planning system. We then compared the clinical dosimetric difference between the two algorithms for ten lung cancer patients receiving stereotactic radiosurgery treatment, by accumulating the delivered dose to the end-of-exhale (EE) phase. Specifically, the respiratory period was divided into ten phases and the dose to each phase was calculated and mapped to the EE phase and then accumulated. The displacement vector field generated by Demons-based registration of the source and reference images was used to transfer the dose and energy. The DDM and EMT algorithms produced noticeably different cumulative dose in the regions with sharp mass density variations and/or high dose gradients. For the planning target volume (PTV) and internal target volume (ITV) minimum dose, the difference was up to 11% and 4% respectively. This suggests that DDM might not be adequate for obtaining an accurate dose distribution of the cumulative plan, instead, EMT should be considered.

  18. Digit (2D:4D) ratio is associated with muscle mass (MM) and strength (MS) in older adults: possible effect of in utero androgen exposure.

    PubMed

    Halil, Meltem; Gurel, Esin Ileri; Kuyumcu, Mehmet Emin; Karaismailoglu, Serkan; Yesil, Yusuf; Ozturk, Zeynel Abidin; Yavuz, Burcu Balam; Cankurtaran, Mustafa; Ariogul, Servet

    2013-01-01

    Decline in MM and MS with aging, defined as sarcopenia, is related with physical disability, poor quality of life and death. Its mechanisms are not fully understood. Testosterone increases muscle protein synthesis. However, the effects of in utero androgen exposure to MM and MS in older adults have not been studied. In utero androgen exposure is inversely related with 2D:4D ratio. The aim of this study was to investigate the relationship between 2D:4D ratio as an indicator of in utero androgen exposure and MM and MS in elderly patients. A total of 151 older adults were included. Calf-circumference (CC) and skeletal muscle mass index (SMI) were used for the assessment of MM and hand grip strength for the assessment of MS. Mean age ± SD of the patients was 73.72 ± 6.23. Fifty-two (34.4%) of patients were male, 99 (65.6%) were female. Right and left 2D:4D were significantly and negatively correlated with hand grip strength (r=-0.365, p=0.018 and r=-0.434, p=0.005, respectively), CC (r=-0.422, p=0.002 and r=-0.459, p=0.001, respectively) and SMI (r=-0.354, p=0.018 and r=-0.348, p=0.022, respectively) in men. In women, right and left 2D:4D were significantly and negatively correlated with hand grip strength (r=-0.252, p=0.022 and r=-0.234, p=0.033, respectively), CC (r=-0.229, p=0.024 and r=-0.302, p=0.003, respectively) and SMI (r=-0.382, p<0.001 and r=-0.431, p<0.001, respectively). In this study, we found that 2D:4D ratio was significantly and negatively correlated with parameters depicting MM and MS which may suggest the possible role of in utero androgen exposure in the development of MM and MS loss in the elderly. PMID:23219021

  19. Planck intermediate results. XI. The gas content of dark matter halos: the Sunyaev-Zeldovich-stellar mass relation for locally brightest galaxies

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Balbi, A.; Banday, A. J.; Barreiro, R. B.; Barrena, R.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Bernard, J.-P.; Bersanelli, M.; Bikmaev, I.; Bock, J. J.; Böhringer, H.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bourdin, H.; Burenin, R.; Burigana, C.; Butler, R. C.; Cabella, P.; Chamballu, A.; Chary, R.-R.; Chiang, L.-Y.; Chon, G.; Christensen, P. R.; Clements, D. L.; Colafrancesco, S.; Colombi, S.; Colombo, L. P. L.; Comis, B.; Coulais, A.; Crill, B. P.; Cuttaia, F.; Da Silva, A.; Dahle, H.; Davis, R. J.; de Bernardis, P.; de Gasperis, G.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Démoclès, J.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Dupac, X.; Efstathiou, G.; Enßlin, T. A.; Finelli, F.; Flores-Cacho, I.; Forni, O.; Frailis, M.; Franceschi, E.; Frommert, M.; Galeotta, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Giraud-Héraud, Y.; González-Nuevo, J.; Górski, K. M.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Harrison, D.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, T. R.; Jaffe, A. H.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Khamitov, I.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lawrence, C. R.; Le Jeune, M.; Leonardi, R.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Luzzi, G.; Macías-Pérez, J. F.; MacTavish, C. J.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Marleau, F.; Marshall, D. J.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Mazzotta, P.; Mei, S.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Osborne, S.; Oxborrow, C. A.; Pajot, F.; Paoletti, D.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Piffaretti, R.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Ristorcelli, I.; Rocha, G.; Roman, M.; Rosset, C.; Rossetti, M.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Savini, G.; Scott, D.; Spencer, L.; Starck, J.-L.; Stolyarov, V.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Valenziano, L.; Van Tent, B.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; Wang, W.; Welikala, N.; Weller, J.; White, S. D. M.; White, M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2013-09-01

    We present the scaling relation between Sunyaev-Zeldovich (SZ) signal and stellar mass for almost 260,000 locally brightest galaxies (LBGs) selected from the Sloan Digital Sky Survey (SDSS). These are predominantly the central galaxies of their dark matter halos. We calibrate the stellar-to-halo mass conversion using realistic mock catalogues based on the Millennium Simulation. Applying a multi-frequency matched filter to the Planck data for each LBG, and averaging the results in bins of stellar mass, we measure the mean SZ signal down to M∗ ~ 2 × 1011 M⊙, with a clear indication of signal at even lower stellar mass. We derive the scaling relation between SZ signal and halo mass by assigning halo properties from our mock catalogues to the real LBGs and simulating the Planck observation process. This relation shows no evidence for deviation from a power law over a halo mass range extending from rich clusters down to M500 ~ 2 × 1013 M⊙, and there is a clear indication of signal down to M500 ~ 4 × 1012 M⊙. Planck's SZdetections in such low-mass halos imply that about a quarter of all baryons have now been seen in the form of hot halo gas, and that this gas must be less concentrated than the dark matter in such halos in order to remain consistent with X-ray observations. At the high-mass end, the measured SZ signal is 20% lower than found from observations of X-ray clusters, a difference consistent with the magnitude of Malmquist bias effects that were previously estimated for the X-ray sample.

  20. Estimation of volcanic ash emissions with satellite data: The inclusion of mass loading and plume height information in modified 4D-Var

    NASA Astrophysics Data System (ADS)

    Lu, Sha; Lin, Hai Xiang; Heemink, Arnold; Segers, Arjo; Fu, Guangliang

    2015-04-01

    Volcanic ash forecasting is a critical tool in hazard assessment and operational volcano monitoring. Emission parameters such as injection height, total emission mass and vertical distribution of the emission plume rate are essential and important in the implementation of volcanic ash models. Satellite instrument is a powerful tool to monitor volcanic aerosol evolution and satellite total-column data has been integrated in the modeling process to achieve a better initial condition for the forecasting. However, the use of total-column data,which has no vertical resolution, usually leads to an ill-conditioned problem and ineffective estimation of emission parameters. Fortunately, techniques to retrieve the information of total ash mass loading and injection height from satellite data has been developed recently. It provides a new possibility to increase the accuracy of estimation results by integrating them into data assimilation systems. In this work we propose a modified 4D-Var approach which seek the vertical emission distribution by observing ash cloud transport patterns from satellite total-ash-columns data, and two ways of including the information of mass loading and plume height in the assimilation process. The modified 4D-Var based on trajectory statistics forms a reformulated cost function which computes the total difference between observed ash columns and a linear combination of simulated ensemble columns coupled with a priori emission knowledge ('background' term). The ensembles are generated by a volcanic ash transport model with the tracer released form different layers. Experiment shows such straightforward method does not always guarantee the identification of injection height with a short assimilation time window, and additional information of injection height is needed to correct the solution. We propose two tricks to incorporate the information: 1. add extra terms containing the information to the cost function as restriction term; 2. generate a

  1. 4-D Photoacoustic Tomography

    NASA Astrophysics Data System (ADS)

    Xiang, Liangzhong; Wang, Bo; Ji, Lijun; Jiang, Huabei

    2013-01-01

    Photoacoustic tomography (PAT) offers three-dimensional (3D) structural and functional imaging of living biological tissue with label-free, optical absorption contrast. These attributes lend PAT imaging to a wide variety of applications in clinical medicine and preclinical research. Despite advances in live animal imaging with PAT, there is still a need for 3D imaging at centimeter depths in real-time. We report the development of four dimensional (4D) PAT, which integrates time resolutions with 3D spatial resolution, obtained using spherical arrays of ultrasonic detectors. The 4D PAT technique generates motion pictures of imaged tissue, enabling real time tracking of dynamic physiological and pathological processes at hundred micrometer-millisecond resolutions. The 4D PAT technique is used here to image needle-based drug delivery and pharmacokinetics. We also use this technique to monitor 1) fast hemodynamic changes during inter-ictal epileptic seizures and 2) temperature variations during tumor thermal therapy.

  2. 4D Electron Tomography

    NASA Astrophysics Data System (ADS)

    Kwon, Oh-Hoon; Zewail, Ahmed H.

    2010-06-01

    Electron tomography provides three-dimensional (3D) imaging of noncrystalline and crystalline equilibrium structures, as well as elemental volume composition, of materials and biological specimens, including those of viruses and cells. We report the development of 4D electron tomography by integrating the fourth dimension (time resolution) with the 3D spatial resolution obtained from a complete tilt series of 2D projections of an object. The different time frames of tomograms constitute a movie of the object in motion, thus enabling studies of nonequilibrium structures and transient processes. The method was demonstrated using carbon nanotubes of a bracelet-like ring structure for which 4D tomograms display different modes of motion, such as breathing and wiggling, with resonance frequencies up to 30 megahertz. Applications can now make use of the full space-time range with the nanometer-femtosecond resolution of ultrafast electron tomography.

  3. A mass, momentum, and energy conserving, fully implicit, scalable algorithm for the multi-dimensional, multi-species Rosenbluth-Fokker-Planck equation

    NASA Astrophysics Data System (ADS)

    Taitano, W. T.; Chacón, L.; Simakov, A. N.; Molvig, K.

    2015-09-01

    In this study, we demonstrate a fully implicit algorithm for the multi-species, multidimensional Rosenbluth-Fokker-Planck equation which is exactly mass-, momentum-, and energy-conserving, and which preserves positivity. Unlike most earlier studies, we base our development on the Rosenbluth (rather than Landau) form of the Fokker-Planck collision operator, which reduces complexity while allowing for an optimal fully implicit treatment. Our discrete conservation strategy employs nonlinear constraints that force the continuum symmetries of the collision operator to be satisfied upon discretization. We converge the resulting nonlinear system iteratively using Jacobian-free Newton-Krylov methods, effectively preconditioned with multigrid methods for efficiency. Single- and multi-species numerical examples demonstrate the advertised accuracy properties of the scheme, and the superior algorithmic performance of our approach. In particular, the discretization approach is numerically shown to be second-order accurate in time and velocity space and to exhibit manifestly positive entropy production. That is, H-theorem behavior is indicated for all the examples we have tested. The solution approach is demonstrated to scale optimally with respect to grid refinement (with CPU time growing linearly with the number of mesh points), and timestep (showing very weak dependence of CPU time with time-step size). As a result, the proposed algorithm delivers several orders-of-magnitude speedup vs. explicit algorithms.

  4. 4D volcano gravimetry

    USGS Publications Warehouse

    Battaglia, Maurizio; Gottsmann, J.; Carbone, D.; Fernandez, J.

    2008-01-01

    Time-dependent gravimetric measurements can detect subsurface processes long before magma flow leads to earthquakes or other eruption precursors. The ability of gravity measurements to detect subsurface mass flow is greatly enhanced if gravity measurements are analyzed and modeled with ground-deformation data. Obtaining the maximum information from microgravity studies requires careful evaluation of the layout of network benchmarks, the gravity environmental signal, and the coupling between gravity changes and crustal deformation. When changes in the system under study are fast (hours to weeks), as in hydrothermal systems and restless volcanoes, continuous gravity observations at selected sites can help to capture many details of the dynamics of the intrusive sources. Despite the instrumental effects, mainly caused by atmospheric temperature, results from monitoring at Mt. Etna volcano show that continuous measurements are a powerful tool for monitoring and studying volcanoes.Several analytical and numerical mathematical models can beused to fit gravity and deformation data. Analytical models offer a closed-form description of the volcanic source. In principle, this allows one to readily infer the relative importance of the source parameters. In active volcanic sites such as Long Valley caldera (California, U.S.A.) and Campi Flegrei (Italy), careful use of analytical models and high-quality data sets has produced good results. However, the simplifications that make analytical models tractable might result in misleading volcanological inter-pretations, particularly when the real crust surrounding the source is far from the homogeneous/ isotropic assumption. Using numerical models allows consideration of more realistic descriptions of the sources and of the crust where they are located (e.g., vertical and lateral mechanical discontinuities, complex source geometries, and topography). Applications at Teide volcano (Tenerife) and Campi Flegrei demonstrate the

  5. Latest results from Planck

    NASA Astrophysics Data System (ADS)

    Tauber, Jan; sSubmitted Planck Collaboration

    2016-01-01

    This talk will present an overview of the most recent Planck data and results, with emphasis on polarization.The use of CMB polarization data from Planck confirms the best-fit Lambda-CDM model obtained with Planck temperature-only data, and improves the accuracy with which cosmological parameters are determined. The most recent results based on polarized E-mode and B-mode CMB power spectra at large angular scales will be presented, and their implications for the epoch of reionization and primordial gravitational waves.In this talk I will also present the latest analysis of polarized diffuse galactic foreground emissions based on Planck data. Both the synchrotron and dust emission maps obtained from Planck reveal new facets of the galactic interstellar medium. In particular dust emission holds the promise of providing a model of the large-scale 3D shape of the Galactic magnetic field, as well as its small scale behavior.

  6. Einstein and Planck

    NASA Astrophysics Data System (ADS)

    Heilbron, John

    2005-03-01

    As an editor of the Annalen der Physik, Max Planck published Einstein's early papers on thermodynamics and on special relativity, which Planck probably was the first major physicist to appreciate. They respected one another not only as physicists but also, for their inspired creation of world pictures, as artists. Planck helped to establish Einstein in a sinecure at the center of German physics, Berlin. Despite their differences in scientific style, social life, politics, and religion, they became fast friends. Their mutual admiration survived World War I, during which Einstein advocated pacifism and Planck signed the infamous Manifesto of the 93 Intellectuals supporting the German invasion of Belgium. It also survived the Weimar Republic, which Einstein favored and Planck disliked. Physics drew them together, as both opposed the Copenhagen Interpretation; so did common decency, as Planck helped to protect Einstein from anti-semitic attacks. Their friendship did not survive the Nazis. As a standing secretary of the Berlin Academy, Planck had to advise Einstein to resign from it before his colleagues, outraged at his criticism of the new Germany from the safety of California, expelled him. Einstein never forgave his old friend and former fellow artist for not protesting publicly against his expulsion and denigration, and other enormities of National Socialism. .

  7. Halo and subhalo demographics with Planck cosmological parameters: Bolshoi-Planck and MultiDark-Planck simulations

    NASA Astrophysics Data System (ADS)

    Rodríguez-Puebla, Aldo; Behroozi, Peter; Primack, Joel; Klypin, Anatoly; Lee, Christoph; Hellinger, Doug

    2016-10-01

    We report and provide fitting functions for the abundance of dark matter haloes and subhaloes as a function of mass, circular velocity, and redshift from the new Bolshoi-Planck and MultiDark-Planck ΛCDM cosmological simulations, based on the Planck parameters. We also report halo mass accretion rates and concentrations. We show that the higher cosmological matter density of the Planck parameters compared with the WMAP parameters leads to higher abundance of massive haloes at high redshifts. We find that the median halo spin parameter {λ _B}= J(√{2}M_virR_virV_vir)^{-1} is nearly independent of redshift, leading to predicted evolution of galaxy sizes that is consistent with observations, while the significant decrease with redshift in median {λ _P}= J|E|^{-1/2}G^{-1}M^{-5/2} predicts more decrease in galaxy sizes than is observed. Using the Tully-Fisher and Faber-Jackson relations between galaxy velocity and mass, we show that a simple model of how galaxy velocity is related to halo maximum circular velocity leads to increasing overprediction of cosmic stellar mass density as redshift increases beyond z ˜ 1, implying that such velocity-mass relations must change at z ≳ 1. By making a realistic model of how observed galaxy velocities are related to halo circular velocity, we show that recent optical and radio observations of the abundance of galaxies are in good agreement with our ΛCDM simulations. Our halo demographics are based on updated versions of the ROCKSTAR and CONSISTENT TREES codes, and this paper includes appendices explaining all of their outputs. This paper is an introduction to a series of related papers presenting other analyses of the Bolshoi-Planck and MultiDark-Planck simulations.

  8. [Critical mass, explosive participation at the Max-Planck Institute about research of the living conditions of the scientific-technical world in Starnberg].

    PubMed

    Sonntag, Philipp

    2014-01-01

    Reviewers of the Max-Planck-Institut zur Erforschung der Lebensbedingungen der wissenschaftlich-technischen Welt (MPIL) did focus upon an abundance of vague reports of evaluative commissions, of benchmarking, of scientific modes. Thus it remained rather neglected, what staff actually had researched. An example: Progression and end of project AKR (Work-Consumption-Assessment) does display all kinds of related emotions at MPIL, and the sensitive guidance by Carl Friedrich von Weizsäcker.

  9. Cosmological constraints on neutrinos with Planck data

    SciTech Connect

    Spinelli, M.

    2015-07-15

    Neutrinos take part in the dance of the evolving Universe influencing its history from leptogenesis, to Big Bang nucleosynthesis, until late time structure formation. This makes cosmology, and in particular one of its primary observables the Cosmic Microwave Background (CMB), an unusual but valuable tool for testing Neutrino Physics. The best measurement to date of full-sky CMB anisotropies comes from the Planck satellite launched in 2009 by the European Space Agency (ESA) and successful follower of COBE and WMAP. Testing Planck data against precise theoretical predictions allow us to shed light on various interesting open questions such as the value of the absolute scale of neutrino masses or their energy density. We revise here the results concerning neutrinos obtained by the Planck Collaboration in the 2013 data release.

  10. Cosmological constraints on neutrinos with Planck data

    NASA Astrophysics Data System (ADS)

    Spinelli, M.

    2015-07-01

    Neutrinos take part in the dance of the evolving Universe influencing its history from leptogenesis, to Big Bang nucleosynthesis, until late time structure formation. This makes cosmology, and in particular one of its primary observables the Cosmic Microwave Background (CMB), an unusual but valuable tool for testing Neutrino Physics. The best measurement to date of full-sky CMB anisotropies comes from the Planck satellite launched in 2009 by the European Space Agency (ESA) and successful follower of COBE and WMAP. Testing Planck data against precise theoretical predictions allow us to shed light on various interesting open questions such as the value of the absolute scale of neutrino masses or their energy density. We revise here the results concerning neutrinos obtained by the Planck Collaboration in the 2013 data release.

  11. The Planck Radiation Functions.

    ERIC Educational Resources Information Center

    Larsen, Russell D.

    1985-01-01

    Blackbody radiation is used as an example to illustrate that oversimplification in teaching quantum ideas can result in later misunderstanding. Although textbooks give Planck's distribution function in terms of wavelength, there are actually 12 different radiation functions. Some of the more interesting ones are given and discussed. (JN)

  12. The Planck Legacy Archive

    NASA Astrophysics Data System (ADS)

    Dupac, X.; Arviset, C.; Fernandez Barreiro, M.; Lopez-Caniego, M.; Tauber, J.

    2015-12-01

    The Planck Collaboration has released in 2015 their second major dataset through the Planck Legacy Archive (PLA). It includes cosmological, Extragalactic and Galactic science data in temperature (intensity) and polarization. Full-sky maps are provided with unprecedented angular resolution and sensitivity, together with a large number of ancillary maps, catalogues (generic, SZ clusters and Galactic cold clumps), time-ordered data and other information. The extensive cosmological likelihood package allows cosmologists to fully explore the plausible parameters of the Universe. A new web-based PLA user interface is made public since Dec. 2014, allowing easier and faster access to all Planck data, and replacing the previous Java-based software. Numerous additional improvements to the PLA are also being developed through the so-called PLA Added-Value Interface, making use of an external contract with the Planetek Hellas and Expert Analytics software companies. This will allow users to process time-ordered data into sky maps, separate astrophysical components in existing maps, simulate the microwave and infrared sky through the Planck Sky Model, and use a number of other functionalities.

  13. Axion hot dark matter bounds after Planck

    SciTech Connect

    Archidiacono, Maria; Hannestad, Steen; Mirizzi, Alessandro; Raffelt, Georg; Wong, Yvonne Y.Y. E-mail: sth@phys.au.dk E-mail: raffelt@mpp.mpg.de

    2013-10-01

    We use cosmological observations in the post-Planck era to derive limits on thermally produced cosmological axions. In the early universe such axions contribute to the radiation density and later to the hot dark matter fraction. We find an upper limit m{sub a} < 0.67 eV at 95% C.L. after marginalising over the unknown neutrino masses, using CMB temperature and polarisation data from Planck and WMAP respectively, the halo matter power spectrum extracted from SDSS-DR7, and the local Hubble expansion rate H{sub 0} released by the Carnegie Hubble Program based on a recalibration of the Hubble Space Telescope Key Project sample. Leaving out the local H{sub 0} measurement relaxes the limit somewhat to 0.86 eV, while Planck+WMAP alone constrain the axion mass to 1.01 eV, the first time an upper limit on m{sub a} has been obtained from CMB data alone. Our axion limit is therefore not very sensitive to the tension between the Planck-inferred H{sub 0} and the locally measured value. This is in contrast with the upper limit on the neutrino mass sum, which we find here to range from Σ m{sub ν} < 0.27 eV at 95% C.L. combining all of the aforementioned observations, to 0.84 eV from CMB data alone.

  14. Planck 2013 results. XXXII. The updated Planck catalogue of Sunyaev-Zeldovich sources

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Aussel, H.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Barrena, R.; Bartelmann, M.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bikmaev, I.; Bobin, J.; Bock, J. J.; Böhringer, H.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bridges, M.; Bucher, M.; Burenin, R.; Burigana, C.; Butler, R. C.; Cardoso, J.-F.; Carvalho, P.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chen, X.; Chiang, H. C.; Chiang, L.-Y.; Chon, G.; Christensen, P. R.; Churazov, E.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Comis, B.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Da Silva, A.; Dahle, H.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Démoclès, J.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Dupac, X.; Efstathiou, G.; Enßlin, T. A.; Eriksen, H. K.; Feroz, F.; Ferragamo, A.; Finelli, F.; Flores-Cacho, I.; Forni, O.; Frailis, M.; Franceschi, E.; Fromenteau, S.; Galeotta, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Giardino, G.; Gilfanov, M.; Giraud-Héraud, Y.; González-Nuevo, J.; Górski, K. M.; Grainge, K. J. B.; Gratton, S.; Gregorio, A.; Groeneboom, N., E.; Gruppuso, A.; Hansen, F. K.; Hanson, D.; Harrison, D.; Hempel, A.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Hurley-Walker, N.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Khamitov, I.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Laureijs, R. J.; Lawrence, C. R.; Leahy, J. P.; Leonardi, R.; León-Tavares, J.; Lesgourgues, J.; Li, C.; Liddle, A.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; MacTavish, C. J.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Mei, S.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mikkelsen, K.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nastasi, A.; Nati, F.; Natoli, P.; Nesvadba, N. P. H.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; O'Dwyer, I. J.; Olamaie, M.; Osborne, S.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrott, Y. C.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rumsey, C.; Rusholme, B.; Sandri, M.; Santos, D.; Saunders, R. D. E.; Savini, G.; Schammel, M. P.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Shimwell, T. W.; Spencer, L. D.; Starck, J.-L.; Stolyarov, V.; Stompor, R.; Streblyanska, A.; Sudiwala, R.; Sunyaev, R.; Sureau, F.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Tavagnacco, D.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tramonte, D.; Tristram, M.; Tucci, M.; Tuovinen, J.; Türler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vibert, L.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; White, M.; White, S. D. M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2015-09-01

    We update the all-sky Planck catalogue of 1227 clusters and cluster candidates (PSZ1) published in March 2013, derived from detections of the Sunyaev-Zeldovich (SZ) effect using the first 15.5 months of Planck satellite observations. As an addendum, we deliver an updated version of the PSZ1 catalogue, reporting the further confirmation of 86 Planck-discovered clusters. In total, the PSZ1 now contains 947 confirmed clusters, of which 214 were confirmed as newly discovered clusters through follow-up observations undertaken by the Planck Collaboration. The updated PSZ1 contains redshifts for 913 systems, of which 736 (~ 80.6%) are spectroscopic, and associated mass estimates derived from the Yz mass proxy. We also provide a new SZ quality flag for the remaining 280 candidates. This flag was derived from a novel artificial neural-network classification of the SZ signal. Based on this assessment, the purity of the updated PSZ1 catalogue is estimated to be 94%. In this release, we provide the full updated catalogue and an additional readme file with further information on the Planck SZ detections. The catalogue is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/581/A14

  15. Beyond the Planck Scale

    SciTech Connect

    Giddings, Steven B.

    2009-12-15

    I outline motivations for believing that important quantum gravity effects lie beyond the Planck scale at both higher energies and longer distances and times. These motivations arise in part from the study of ultra-high energy scattering, and also from considerations in cosmology. I briefly summarize some inferences about such ultra-planckian physics, and clues we might pursue towards the principles of a more fundamental theory addressing the known puzzles and paradoxes of quantum gravity.

  16. Warming up for Planck

    SciTech Connect

    Bartrum, Sam; Berera, Arjun; Rosa, João G. E-mail: ab@ph.ed.ac.uk

    2013-06-01

    The recent Planck results and future releases on the horizon present a key opportunity to address a fundamental question in inflationary cosmology of whether primordial density perturbations have a quantum or thermal origin, i.e. whether particle production may have significant effects during inflation. Warm inflation provides a natural arena to address this issue, with interactions between the scalar inflaton and other degrees of freedom leading to dissipative entropy production and associated thermal fluctuations. In this context, we present relations between CMB observables that can be directly tested against observational data. In particular, we show that the presence of a thermal bath warmer than the Hubble scale during inflation decreases the tensor-to-scalar ratio with respect to the conventional prediction in supercooled inflation, yielding r < 8|n{sub t}|, where n{sub t} is the tensor spectral index. Focusing on supersymmetric models at low temperatures, we determine consistency relations between the observables characterizing the spectrum of adiabatic scalar and tensor modes, both for generic potentials and particular canonical examples, and which we compare with the WMAP and Planck results. Finally, we include the possibility of producing the observed baryon asymmetry during inflation through dissipative effects, thereby generating baryon isocurvature modes that can be easily accommodated by the Planck data.

  17. Black hole remnants due to Planck-length deformed QFT

    NASA Astrophysics Data System (ADS)

    Dirkes, Alain R. P.; Maziashvili, Michael; Silagadze, Zurab K.

    2016-10-01

    It was argued in a number of papers that the gravitational potential calculated by using the modified QFT that follows from the Planck-length deformed uncertainty relation implies the existence of black hole (BH) remnants of the order of the Planck mass. Usually, this sort of QFTs are endowed with two specific features, the modified dispersion relation, which is universal, and the concept of minimum length, which, however, is not universal. While the emergence of the minimum length most readily leads to the idea of the BH remnants, here, we examine the behavior of the potential that follows from the Planck-length deformed QFT in the absence of the minimum length and show that it might also lead to the formation of the Planck mass BHs in some particular cases. The calculations are made for higher-dimensional case as well. Such BH remnants might be considered as a possible candidates for the dark-matter.

  18. The Planck Telescope reflectors

    NASA Astrophysics Data System (ADS)

    Stute, Thomas

    2004-09-01

    The mechanical division of EADS-Astrium GmbH, Friedrichshafen is currently engaged with the development, manufacturing and testing of the advanced dimensionally stable composite reflectors for the ESA satellite borne telescope Planck. The objective of the ESA mission Planck is to analyse the first light that filled the universe, the cosmic microwave background radiation. Under contract of the Danish Space Research Institute and ESA EADS-Astrium GmbH is developing the all CFRP primary and secondary reflectors for the 1.5-metre telescope which is the main instrument of the Planck satellite. The operational frequency ranges from to 25 GHz to 1000 GHz. The demanding high contour accuracy and surface roughness requirements are met. The design provides the extreme dimensional stability required by the cryogenic operational environment at around 40 K. The elliptical off-axis reflectors display a classical lightweight sandwich design with CFRP core and facesheets. Isostatic mounts provide the interfaces to the telescope structure. Protected VDA provides the reflecting surface. The manufacturing is performed at the Friedrichshafen premises of EADS-Space Transportation GmbH, the former Dornier composite workshops. Advanced manufacturing technologies like true angle lay-up by CNC fibre placement and filament winding are utilized. The protected coating is applied at the CAHA facilities at the Calar Alto Observatory, Spain. The exhaustive environmental testing is performed at the facilities of IABG, Munich (mechanical testing) and for the cryo-optical tests at CSL Liege. The project is in advanced state with both Qualification Models being under environmental testing. The flight models will be delivered in 2004. The paper gives an overview over the requirements and the main structural features how these requirements are met. Special production aspects and available test results are reported.

  19. Why Planck (the Satellite) could have been Zel'dovich

    NASA Astrophysics Data System (ADS)

    Partridge, Bruce

    2016-10-01

    In this brief paper, I cannot provide an overall review of the Planck results to date. Instead I will focus on a handful of results from both Planck and related cosmic microwave background (CMB) experiments that reflect Ya. B. Zel'dovich's legacy in cosmology. These include the Sunyaev-Zel'dovich effect in clusters of galaxies and in the cosmic web, and a map of the overall distribution of mass in the Universe derived from CMB maps.

  20. Quantum Gravity corrections and entropy at the Planck time

    SciTech Connect

    Basilakos, Spyros; Vagenas, Elias C.; Das, Saurya E-mail: saurya.das@uleth.ca

    2010-09-01

    We investigate the effects of Quantum Gravity on the Planck era of the universe. In particular, using different versions of the Generalized Uncertainty Principle and under specific conditions we find that the main Planck quantities such as the Planck time, length, mass and energy become larger by a factor of order 10−10{sup 4} compared to those quantities which result from the Heisenberg Uncertainty Principle. However, we prove that the dimensionless entropy enclosed in the cosmological horizon at the Planck time remains unchanged. These results, though preliminary, indicate that we should anticipate modifications in the set-up of cosmology since changes in the Planck era will be inherited even to the late universe through the framework of Quantum Gravity (or Quantum Field Theory) which utilizes the Planck scale as a fundamental one. More importantly, these corrections will not affect the entropic content of the universe at the Planck time which is a crucial element for one of the basic principles of Quantum Gravity named Holographic Principle.

  1. 4-D OCT in Developmental Cardiology

    NASA Astrophysics Data System (ADS)

    Jenkins, Michael W.; Rollins, Andrew M.

    Although strong evidence exists to suggest that altered cardiac function can lead to CHDs, few studies have investigated the influential role of cardiac function and biophysical forces on the development of the cardiovascular system due to a lack of proper in vivo imaging tools. 4-D imaging is needed to decipher the complex spatial and temporal patterns of biomechanical forces acting upon the heart. Numerous solutions over the past several years have demonstrated 4-D OCT imaging of the developing cardiovascular system. This chapter will focus on these solutions and explain their context in the evolution of 4-D OCT imaging. The first sections describe the relevant techniques (prospective gating, direct 4-D imaging, retrospective gating), while later sections focus on 4-D Doppler imaging and measurements of force implementing 4-D OCT Doppler. Finally, the techniques are summarized, and some possible future directions are discussed.

  2. Probing Planck's Law at Home

    ERIC Educational Resources Information Center

    Bonnet, I.; Gabelli, J.

    2010-01-01

    We report on the physics around an incandescent lamp. Using a consumer-grade digital camera, we combine electrical and optical measurements to explore Planck's law of black-body radiation. This simple teaching experiment is successfully used to measure both Stefan's and Planck's constants. Our measurements lead to a strikingly accurate value for…

  3. Advances in 4D radiation therapy for managing respiration: part I - 4D imaging.

    PubMed

    Hugo, Geoffrey D; Rosu, Mihaela

    2012-12-01

    Techniques for managing respiration during imaging and planning of radiation therapy are reviewed, concentrating on free-breathing (4D) approaches. First, we focus on detailing the historical development and basic operational principles of currently-available "first generation" 4D imaging modalities: 4D computed tomography, 4D cone beam computed tomography, 4D magnetic resonance imaging, and 4D positron emission tomography. Features and limitations of these first generation systems are described, including necessity of breathing surrogates for 4D image reconstruction, assumptions made in acquisition and reconstruction about the breathing pattern, and commonly-observed artifacts. Both established and developmental methods to deal with these limitations are detailed. Finally, strategies to construct 4D targets and images and, alternatively, to compress 4D information into static targets and images for radiation therapy planning are described.

  4. Advances in 4D Radiation Therapy for Managing Respiration: Part I – 4D Imaging

    PubMed Central

    Hugo, Geoffrey D.; Rosu, Mihaela

    2014-01-01

    Techniques for managing respiration during imaging and planning of radiation therapy are reviewed, concentrating on free-breathing (4D) approaches. First, we focus on detailing the historical development and basic operational principles of currently-available “first generation” 4D imaging modalities: 4D computed tomography, 4D cone beam computed tomography, 4D magnetic resonance imaging, and 4D positron emission tomography. Features and limitations of these first generation systems are described, including necessity of breathing surrogates for 4D image reconstruction, assumptions made in acquisition and reconstruction about the breathing pattern, and commonly-observed artifacts. Both established and developmental methods to deal with these limitations are detailed. Finally, strategies to construct 4D targets and images and, alternatively, to compress 4D information into static targets and images for radiation therapy planning are described. PMID:22784929

  5. 2,4-D and IAA Amino Acid Conjugates Show Distinct Metabolism in Arabidopsis

    PubMed Central

    Eyer, Luděk; Vain, Thomas; Pařízková, Barbora; Oklestkova, Jana; Barbez, Elke; Kozubíková, Hana; Pospíšil, Tomáš; Wierzbicka, Roksana; Kleine-Vehn, Jürgen; Fránek, Milan; Strnad, Miroslav; Robert, Stéphanie

    2016-01-01

    The herbicide 2,4-D exhibits an auxinic activity and therefore can be used as a synthetic and traceable analog to study auxin-related responses. Here we identified that not only exogenous 2,4-D but also its amide-linked metabolite 2,4-D-Glu displayed an inhibitory effect on plant growth via the TIR1/AFB auxin-mediated signaling pathway. To further investigate 2,4-D metabolite conversion, identity and activity, we have developed a novel purification procedure based on the combination of ion exchange and immuno-specific sorbents combined with a sensitive liquid chromatography-mass spectrometry method. In 2,4-D treated samples, 2,4-D-Glu and 2,4-D-Asp were detected at 100-fold lower concentrations compared to 2,4-D levels, showing that 2,4-D can be metabolized in the plant. Moreover, 2,4-D-Asp and 2,4-D-Glu were identified as reversible forms of 2,4-D homeostasis that can be converted to free 2,4-D. This work paves the way to new studies of auxin action in plant development. PMID:27434212

  6. 2,4-D and IAA Amino Acid Conjugates Show Distinct Metabolism in Arabidopsis.

    PubMed

    Eyer, Luděk; Vain, Thomas; Pařízková, Barbora; Oklestkova, Jana; Barbez, Elke; Kozubíková, Hana; Pospíšil, Tomáš; Wierzbicka, Roksana; Kleine-Vehn, Jürgen; Fránek, Milan; Strnad, Miroslav; Robert, Stéphanie; Novak, Ondrej

    2016-01-01

    The herbicide 2,4-D exhibits an auxinic activity and therefore can be used as a synthetic and traceable analog to study auxin-related responses. Here we identified that not only exogenous 2,4-D but also its amide-linked metabolite 2,4-D-Glu displayed an inhibitory effect on plant growth via the TIR1/AFB auxin-mediated signaling pathway. To further investigate 2,4-D metabolite conversion, identity and activity, we have developed a novel purification procedure based on the combination of ion exchange and immuno-specific sorbents combined with a sensitive liquid chromatography-mass spectrometry method. In 2,4-D treated samples, 2,4-D-Glu and 2,4-D-Asp were detected at 100-fold lower concentrations compared to 2,4-D levels, showing that 2,4-D can be metabolized in the plant. Moreover, 2,4-D-Asp and 2,4-D-Glu were identified as reversible forms of 2,4-D homeostasis that can be converted to free 2,4-D. This work paves the way to new studies of auxin action in plant development. PMID:27434212

  7. CMB anomalies after Planck

    NASA Astrophysics Data System (ADS)

    Schwarz, Dominik J.; Copi, Craig J.; Huterer, Dragan; Starkman, Glenn D.

    2016-09-01

    Several unexpected features have been observed in the microwave sky at large angular scales, both by WMAP and by Planck. Among those features is a lack of both variance and correlation on the largest angular scales, alignment of the lowest multipole moments with one another and with the motion and geometry of the solar system, a hemispherical power asymmetry or dipolar power modulation, a preference for odd parity modes and an unexpectedly large cold spot in the Southern hemisphere. The individual p-values of the significance of these features are in the per mille to per cent level, when compared to the expectations of the best-fit inflationary ΛCDM model. Some pairs of those features are demonstrably uncorrelated, increasing their combined statistical significance and indicating a significant detection of CMB features at angular scales larger than a few degrees on top of the standard model. Despite numerous detailed investigations, we still lack a clear understanding of these large-scale features, which seem to imply a violation of statistical isotropy and scale invariance of inflationary perturbations. In this contribution we present a critical analysis of our current understanding and discuss several ideas of how to make further progress.

  8. Los Alamos National Laboratory 4D Database

    SciTech Connect

    Atencio, Julian J.

    2014-05-02

    4D is an integrated development platform - a single product comprised of the components you need to create and distribute professional applications. You get a graphical design environment, SQL database, a programming language, integrated PHP execution, HTTP server, application server, executable generator, and much more. 4D offers multi-platform development and deployment, meaning whatever you create on a Mac can be used on Windows, and vice-versa. Beyond productive development, 4D is renowned for its great flexibility in maintenance and modification of existing applications, and its extreme ease of implementation in its numerous deployment options. Your professional application can be put into production more quickly, at a lower cost, and will always be instantly scalable. 4D makes it easy, whether you're looking to create a classic desktop application, a client-server system, a distributed solution for Web or mobile clients - or all of the above!

  9. Planck 2013 results. I. Overview of products and scientific results

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Alves, M. I. R.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Aussel, H.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Barrena, R.; Bartelmann, M.; Bartlett, J. G.; Bartolo, N.; Basak, S.; Battaner, E.; Battye, R.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bertincourt, B.; Bethermin, M.; Bielewicz, P.; Bikmaev, I.; Blanchard, A.; Bobin, J.; Bock, J. J.; Böhringer, H.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bourdin, H.; Bowyer, J. W.; Bridges, M.; Brown, M. L.; Bucher, M.; Burenin, R.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cappellini, B.; Cardoso, J.-F.; Carr, R.; Carvalho, P.; Casale, M.; Castex, G.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chen, X.; Chiang, H. C.; Chiang, L.-Y.; Chon, G.; Christensen, P. R.; Churazov, E.; Church, S.; Clemens, M.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Comis, B.; Couchot, F.; Coulais, A.; Crill, B. P.; Cruz, M.; Curto, A.; Cuttaia, F.; Da Silva, A.; Dahle, H.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Déchelette, T.; Delabrouille, J.; Delouis, J.-M.; Démoclès, J.; Désert, F.-X.; Dick, J.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fabre, O.; Falgarone, E.; Falvella, M. C.; Fantaye, Y.; Fergusson, J.; Filliard, C.; Finelli, F.; Flores-Cacho, I.; Foley, S.; Forni, O.; Fosalba, P.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Freschi, M.; Fromenteau, S.; Frommert, M.; Gaier, T. C.; Galeotta, S.; Gallegos, J.; Galli, S.; Gandolfo, B.; Ganga, K.; Gauthier, C.; Génova-Santos, R. T.; Ghosh, T.; Giard, M.; Giardino, G.; Gilfanov, M.; Girard, D.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Haissinski, J.; Hamann, J.; Hansen, F. K.; Hansen, M.; Hanson, D.; Harrison, D. L.; Heavens, A.; Helou, G.; Hempel, A.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Ho, S.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hou, Z.; Hovest, W.; Huey, G.; Huffenberger, K. M.; Hurier, G.; Ilić, S.; Jaffe, A. H.; Jaffe, T. R.; Jasche, J.; Jewell, J.; Jones, W. C.; Juvela, M.; Kalberla, P.; Kangaslahti, P.; Keihänen, E.; Kerp, J.; Keskitalo, R.; Khamitov, I.; Kiiveri, K.; Kim, J.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lacasa, F.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Langer, M.; Lasenby, A.; Lattanzi, M.; Laureijs, R. J.; Lavabre, A.; Lawrence, C. R.; Le Jeune, M.; Leach, S.; Leahy, J. P.; Leonardi, R.; León-Tavares, J.; Leroy, C.; Lesgourgues, J.; Lewis, A.; Li, C.; Liddle, A.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; Lindholm, V.; López-Caniego, M.; Lowe, S.; Lubin, P. M.; Macías-Pérez, J. F.; MacTavish, C. J.; Maffei, B.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marcos-Caballero, A.; Marinucci, D.; Maris, M.; Marleau, F.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matsumura, T.; Matthai, F.; Maurin, L.; Mazzotta, P.; McDonald, A.; McEwen, J. D.; McGehee, P.; Mei, S.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Menegoni, E.; Mennella, A.; Migliaccio, M.; Mikkelsen, K.; Millea, M.; Miniscalco, R.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Morgante, G.; Morisset, N.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Negrello, M.; Nesvadba, N. P. H.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; North, C.; Noviello, F.; Novikov, D.; Novikov, I.; O'Dwyer, I. J.; Orieux, F.; Osborne, S.; O'Sullivan, C.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Pandolfi, S.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Paykari, P.; Pearson, D.; Pearson, T. J.; Peel, M.; Peiris, H. V.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Platania, P.; Pogosyan, D.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Pullen, A. R.; Rachen, J. P.; Racine, B.; Rahlin, A.; Räth, C.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Riazuelo, A.; Ricciardi, S.; Riller, T.; Ringeval, C.; Ristorcelli, I.; Robbers, G.; Rocha, G.; Roman, M.; Rosset, C.; Rossetti, M.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Ruiz-Granados, B.; Rusholme, B.

    2014-11-01

    The European Space Agency's Planck satellite, dedicated to studying the early Universe and its subsequent evolution, was launched 14 May 2009 and has been scanning the microwave and submillimetre sky continuously since 12 August 2009. In March 2013, ESA and the Planck Collaboration released the initial cosmology products based on the first 15.5 months of Planck data, along with a set of scientific and technical papers and a web-based explanatory supplement. This paper gives an overview of the mission and its performance, the processing, analysis, and characteristics of the data, the scientific results, and the science data products and papers in the release. The science products include maps of the cosmic microwave background (CMB) and diffuse extragalactic foregrounds, a catalogue of compact Galactic and extragalactic sources, and a list of sources detected through the Sunyaev-Zeldovich effect. The likelihood code used to assess cosmological models against the Planck data and a lensing likelihood are described. Scientific results include robust support for the standard six-parameter ΛCDM model of cosmology and improved measurements of its parameters, including a highly significant deviation from scale invariance of the primordial power spectrum. The Planck values for these parameters and others derived from them are significantly different from those previously determined. Several large-scale anomalies in the temperature distribution of the CMB, first detected by WMAP, are confirmed with higher confidence. Planck sets new limits on the number and mass of neutrinos, and has measured gravitational lensing of CMB anisotropies at greater than 25σ. Planck finds no evidence for non-Gaussianity in the CMB. Planck's results agree well with results from the measurements of baryon acoustic oscillations. Planck finds a lower Hubble constant than found in some more local measures. Some tension is also present between the amplitude of matter fluctuations (σ8) derived from

  10. Planck 2015 results. XIII. Cosmological parameters

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Bartolo, N.; Battaner, E.; Battye, R.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chiang, H. C.; Chluba, J.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Di Valentino, E.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Farhang, M.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Gauthier, C.; Gerbino, M.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Giusarma, E.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hamann, J.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huang, Z.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leahy, J. P.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Lewis, A.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marchini, A.; Maris, M.; Martin, P. G.; Martinelli, M.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Millea, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rouillé d'Orfeuil, B.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rusholme, B.; Said, N.; Salvatelli, V.; Salvati, L.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Serra, P.; Shellard, E. P. S.; Spencer, L. D.; Spinelli, M.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Trombetti, T.; Tucci, M.; Tuovinen, J.; Türler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, F.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; White, M.; White, S. D. M.; Wilkinson, A.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    This paper presents cosmological results based on full-mission Planck observations of temperature and polarization anisotropies of the cosmic microwave background (CMB) radiation. Our results are in very good agreement with the 2013 analysis of the Planck nominal-mission temperature data, but with increased precision. The temperature and polarization power spectra are consistent with the standard spatially-flat 6-parameter ΛCDM cosmology with a power-law spectrum of adiabatic scalar perturbations (denoted "base ΛCDM" in this paper). From the Planck temperature data combined with Planck lensing, for this cosmology we find a Hubble constant, H0 = (67.8 ± 0.9) km s-1Mpc-1, a matter density parameter Ωm = 0.308 ± 0.012, and a tilted scalar spectral index with ns = 0.968 ± 0.006, consistent with the 2013 analysis. Note that in this abstract we quote 68% confidence limits on measured parameters and 95% upper limits on other parameters. We present the first results of polarization measurements with the Low Frequency Instrument at large angular scales. Combined with the Planck temperature and lensing data, these measurements give a reionization optical depth of τ = 0.066 ± 0.016, corresponding to a reionization redshift of z_re=8.8+1.7-1.4. These results are consistent with those from WMAP polarization measurements cleaned for dust emission using 353-GHz polarization maps from the High Frequency Instrument. We find no evidence for any departure from base ΛCDM in the neutrino sector of the theory; for example, combining Planck observations with other astrophysical data we find Neff = 3.15 ± 0.23 for the effective number of relativistic degrees of freedom, consistent with the value Neff = 3.046 of the Standard Model of particle physics. The sum of neutrino masses is constrained to ∑ mν < 0.23 eV. The spatial curvature of our Universe is found to be very close to zero, with | ΩK | < 0.005. Adding a tensor component as a single-parameter extension to base

  11. Helical 4D CT and Comparison with Cine 4D CT

    NASA Astrophysics Data System (ADS)

    Pan, Tinsu

    4D CT was one of the most important developments in radiation oncology in the last decade. Its early development in single slice CT and commercialization in multi-slice CT has radically changed our practice in radiation treatment of lung cancer, and has enabled the stereotactic radiosurgery of early stage lung cancer. In this chapter, we will document the history of 4D CT development, detail the data sufficiency condition governing the 4D CT data collection; present the design of the commercial helical 4D CTs from Philips and Siemens; compare the differences between the helical 4D CT and the GE cine 4D CT in data acquisition, slice thickness, acquisition time and work flow; review the respiratory monitoring devices; and understand the causes of image artifacts in 4D CT.

  12. 4D flow imaging with MRI

    PubMed Central

    Stankovic, Zoran; Allen, Bradley D.; Garcia, Julio; Jarvis, Kelly B.

    2014-01-01

    Magnetic resonance imaging (MRI) has become an important tool for the clinical evaluation of patients with cardiovascular disease. Since its introduction in the late 1980s, 2-dimensional phase contrast MRI (2D PC-MRI) has become a routine part of standard-of-care cardiac MRI for the assessment of regional blood flow in the heart and great vessels. More recently, time-resolved PC-MRI with velocity encoding along all three flow directions and three-dimensional (3D) anatomic coverage (also termed ‘4D flow MRI’) has been developed and applied for the evaluation of cardiovascular hemodynamics in multiple regions of the human body. 4D flow MRI allows for the comprehensive evaluation of complex blood flow patterns by 3D blood flow visualization and flexible retrospective quantification of flow parameters. Recent technical developments, including the utilization of advanced parallel imaging techniques such as k-t GRAPPA, have resulted in reasonable overall scan times, e.g., 8-12 minutes for 4D flow MRI of the aorta and 10-20 minutes for whole heart coverage. As a result, the application of 4D flow MRI in a clinical setting has become more feasible, as documented by an increased number of recent reports on the utility of the technique for the assessment of cardiac and vascular hemodynamics in patient studies. A number of studies have demonstrated the potential of 4D flow MRI to provide an improved assessment of hemodynamics which might aid in the diagnosis and therapeutic management of cardiovascular diseases. The purpose of this review is to describe the methods used for 4D flow MRI acquisition, post-processing and data analysis. In addition, the article provides an overview of the clinical applications of 4D flow MRI and includes a review of applications in the heart, thoracic aorta and hepatic system. PMID:24834414

  13. Phosphodiesterase4D (PDE4D)--A risk factor for atrial fibrillation and stroke?

    PubMed

    Jørgensen, Carina; Yasmeen, Saiqa; Iversen, Helle K; Kruuse, Christina

    2015-12-15

    Mutations in the gene encoding phosphodiesterase 4D (PDE4D) enzyme are associated with ischemic stroke; however the functional implications of such mutations are not well understood. PDE4D is part of a complex protein family modulating intracellular signalling by cyclic nucleotides. The PDE4 family includes subtypes A-D, all of which show unique intracellular, cellular and tissue distribution. PDE4D is the major subtype expressed in human atrial myocytes and involved in the pathophysiology of arrhythmias, such as atrial fibrillation. The PDE4D enzyme hydrolyses cyclic adenosine monophosphate (cAMP). Though diverging results are reported, several population based studies describe association of various PDE4D single nucleotide polymorphisms (SNP) with cardio-embolic stroke in particular. Functionally, a down regulation of PDE4D variants has been reported in stroke patients. The anti-inflammatory and vasodilator properties of PDE4 inhibitors make them suitable for treatment of stroke and cardiovascular disease. PDE4D has recently been suggested as factor in atrial fibrillation. This review summarizes the possible function of PDE4D in the brain, heart, and vasculature. Further, association of the described SNPs, in particular, with cardioembolic stroke, is reviewed. Current findings on the PDE4D mutations suggest functionality involves an increased cardiac risk factor as well as augmented risk of atrial fibrillation. PMID:26671126

  14. Characterizing Planck SZ detected clusters with X-ray observations

    NASA Astrophysics Data System (ADS)

    Lovisari, L.; Forman, W.; Jones, C.; Kraft, R.; Randall, S.; Santos, F.

    2016-06-01

    Galaxy clusters are a powerful tool to constrain cosmological parameters. An accurate knowledge of the scaling relations between X-ray observables and cluster mass is a crucial step because it will enable us to compare the theoretical predictions with the real data and with the cosmological models. A complete sample is required for any meaningful study of the scaling properties, otherwise potentially important biases (e.g. Malmquist bias, cool-core and merger fractions) cannot be corrected. The Planck mission provided a nearly complete mass-limited sample of clusters of galaxies. From XMM-Newton and/or Chandra observations of the 165 Planck ESZ clusters at z <0.35, we derived the total mass, gas mass, X-ray luminosity, temperature, and morphology of each cluster. We will show how the cluster properties and morphologies differ for X-ray and SZ selected samples. In particular we will show that the Planck sample has a smaller fraction of cool-core clusters than X-ray selected samples. We will show the derived X-ray scaling relations for the Planck SZ selected sample. Finally, we will show the preliminary results of the cluster mass function.

  15. Planck scale effects in neutrino physics

    NASA Astrophysics Data System (ADS)

    Akhmedov, E. K.; Senjanovic, G.; Tao, Zhi-Jan; Berezhiani, Z. G.

    1992-08-01

    We study the phenomenology and cosmology of the Majoron (flavon) models of one inert neutrino and three active ones. We pay special attention to the possible (almost) conserved generalization of the Zeldovich-Konopinski-Mahmoud lepton charge. Using Planck scale physics effects, which provide the breaking of the lepton charge, we show how, in this picture, one can incorporate the solutions to some of the central issues in neutrino physics, such as the solar and atmospheric neutrino puzzles, dark matter, and a 17 keV neutrino. These gravitation effects induce tiny Majorana mass terms for neutrinos and considerable masses for flavons. The cosmological demand for the sufficiently fast decay of flavons implies a lower limit on the electron neutrino mass in the range of 0.1-1 eV.

  16. Planck scale effects in neutrino physics

    NASA Astrophysics Data System (ADS)

    Akhmedov, Eugeni Kh.; Berezhiani, Zurab G.; Senjanović, Goran; Tao, Zhijian

    1993-04-01

    We study the phenomenology and cosmology of the Majoron (flavon) models of three active and one inert neutrino paying special attention to the possible (almost) conserved generalization of the Zeldovich-Konopinski-Mahmoud lepton charge. Using Planck scale physics effects which provide the breaking of the lepton charge, we show how in this picture one can incorporate the solutions to some of the central issues in neutrino physics such as the solar and atmospheric neutrino puzzles and the dark matter problem with the possible existence of a heavy (1-10 keV) neutrino. These gravitational effects induce tiny Majorana mass terms for neutrinos and considerable masses for flavons. The cosmological demand for the sufficiently fast decay of flavons implies a lower limit on the electron-neutrino mass in the range of 0.1-1 eV.

  17. Shadow-driven 4D haptic visualization.

    PubMed

    Zhang, Hui; Hanson, Andrew

    2007-01-01

    Just as we can work with two-dimensional floor plans to communicate 3D architectural design, we can exploit reduced-dimension shadows to manipulate the higher-dimensional objects generating the shadows. In particular, by taking advantage of physically reactive 3D shadow-space controllers, we can transform the task of interacting with 4D objects to a new level of physical reality. We begin with a teaching tool that uses 2D knot diagrams to manipulate the geometry of 3D mathematical knots via their projections; our unique 2D haptic interface allows the user to become familiar with sketching, editing, exploration, and manipulation of 3D knots rendered as projected imageson a 2D shadow space. By combining graphics and collision-sensing haptics, we can enhance the 2D shadow-driven editing protocol to successfully leverage 2D pen-and-paper or blackboard skills. Building on the reduced-dimension 2D editing tool for manipulating 3D shapes, we develop the natural analogy to produce a reduced-dimension 3D tool for manipulating 4D shapes. By physically modeling the correct properties of 4D surfaces, their bending forces, and their collisions in the 3D haptic controller interface, we can support full-featured physical exploration of 4D mathematical objects in a manner that is otherwise far beyond the experience accessible to human beings. As far as we are aware, this paper reports the first interactive system with force-feedback that provides "4D haptic visualization" permitting the user to model and interact with 4D cloth-like objects.

  18. Planck 2015 results. XXVIII. The Planck Catalogue of Galactic cold clumps

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Catalano, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Falgarone, E.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; McGehee, P.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Pelkonen, V.-M.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-08-01

    We present the Planck Catalogue of Galactic Cold Clumps (PGCC), an all-sky catalogue of Galactic cold clump candidates detected by Planck. This catalogue is the full version of the Early Cold Core (ECC) catalogue, which was made available in 2011 with the Early Release Compact Source Catalogue (ERCSC) and which contained 915 high signal-to-noise sources. It is based on the Planck 48-month mission data that are currently being released to the astronomical community. The PGCC catalogue is an observational catalogue consisting exclusively of Galactic cold sources. The three highest Planck bands (857, 454, and 353 GHz) have been combined with IRAS data at 3 THz to perform a multi-frequency detection of sources colder than their local environment. After rejection of possible extragalactic contaminants, the PGCC catalogue contains 13188 Galactic sources spread across the whole sky, i.e., from the Galactic plane to high latitudes, following the spatial distribution of the main molecular cloud complexes. The median temperature of PGCC sources lies between 13 and 14.5 K, depending on the quality of the flux density measurements, with a temperature ranging from 5.8 to 20 K after removing the sources with the top 1% highest temperature estimates. Using seven independent methods, reliable distance estimates have been obtained for 5574 sources, which allows us to derive their physical properties such as their mass, physical size, mean density, and luminosity.The PGCC sources are located mainly in the solar neighbourhood, but also up to a distance of 10.5 kpc in the direction of the Galactic centre, and range from low-mass cores to large molecular clouds. Because of this diversity and because the PGCC catalogue contains sources in very different environments, the catalogue is useful for investigating the evolution from molecular clouds to cores. Finally, it also includes 54 additional sources located in the Small and Large Magellanic Clouds.

  19. 4D Confocal Imaging of Yeast Organelles.

    PubMed

    Day, Kasey J; Papanikou, Effrosyni; Glick, Benjamin S

    2016-01-01

    Yeast cells are well suited to visualizing organelles by 4D confocal microscopy. Typically, one or more cellular compartments are labeled with a fluorescent protein or dye, and a stack of confocal sections spanning the entire cell volume is captured every few seconds. Under appropriate conditions, organelle dynamics can be observed for many minutes with only limited photobleaching. Images are captured at a relatively low signal-to-noise ratio and are subsequently processed to generate movies that can be analyzed and quantified. Here, we describe methods for acquiring and processing 4D data using conventional scanning confocal microscopy. PMID:27631997

  20. The scientific value of 4D visualizations

    NASA Astrophysics Data System (ADS)

    Minster, J.; Olsen, K.; Day, S.; Moore, R.; Jordan, T. H.; Maechling, P.; Chourasia, A.

    2006-12-01

    Significant scientific insights derive from viewing measured, or calculated three-dimensional, time-dependent -- that is four-dimensional-- fields. This issue cuts across all disciplines of Earth Sciences. Addressing it calls for close collaborations between "domain" scientists and "IT" visualization specialists. Techniques to display such 4D fields in a intuitive way are a major challenge, especially when the relevant variables to be displayed are not scalars but tensors. This talk will illustrate some attempts to deal with this challenge, using seismic wave fields as specific objects to display. We will highlight how 4D displays can help address very difficult issues of significant scientific import.

  1. Planck constraints on monodromy inflation

    SciTech Connect

    Easther, Richard; Flauger, Raphael E-mail: flauger@ias.edu

    2014-02-01

    We use data from the nominal Planck mission to constrain modulations in the primordial power spectrum associated with monodromy inflation. The largest improvement in fit relative to the unmodulated model has Δχ{sup 2} ≈ 10 and we find no evidence for a primordial signal, in contrast to a previous analysis of the WMAP9 dataset, for which Δχ{sup 2} ≈ 20. The Planck and WMAP9 results are broadly consistent on angular scales where they are expected to agree as far as best-fit values are concerned. However, even on these scales the significance of the signal is reduced in Planck relative to WMAP, and is consistent with a fit to the ''noise'' associated with cosmic variance. Our results motivate both a detailed comparison between the two experiments and a more careful study of the theoretical predictions of monodromy inflation.

  2. String inflation after Planck 2013

    SciTech Connect

    Burgess, C.P.; Cicoli, M.; Quevedo, F. E-mail: mcicoli@ictp.it

    2013-11-01

    We briefly summarize the impact of the recent Planck measurements for string inflationary models, and outline what might be expected to be learned in the near future from the expected improvement in sensitivity to the primordial tensor-to-scalar ratio. We comment on whether these models provide sufficient added value to compensate for their complexity, and ask how they fare in the face of the new constraints on non-gaussianity and dark radiation. We argue that as a group the predictions made before Planck agree well with what has been seen, and draw conclusions from this about what is likely to mean as sensitivity to primordial gravitational waves improves.

  3. Constrained reconstructions for 4D intervention guidance.

    PubMed

    Kuntz, J; Flach, B; Kueres, R; Semmler, W; Kachelriess, M; Bartling, S

    2013-05-21

    Image-guided interventions are an increasingly important part of clinical minimally invasive procedures. However, up to now they cannot be performed under 4D (3D + time) guidance due to the exceedingly high x-ray dose. In this work we investigate the applicability of compressed sensing reconstructions for highly undersampled CT datasets combined with the incorporation of prior images in order to yield low dose 4D intervention guidance. We present a new reconstruction scheme prior image dynamic interventional CT (PrIDICT) that accounts for specific image features in intervention guidance and compare it to PICCS and ASD-POCS. The optimal parameters for the dose per projection and the numbers of projections per reconstruction are determined in phantom simulations and measurements. In vivo experiments in six pigs are performed in a cone-beam CT; measured doses are compared to current gold-standard intervention guidance represented by a clinical fluoroscopy system. Phantom studies show maximum image quality for identical overall doses in the range of 14 to 21 projections per reconstruction. In vivo studies reveal that interventional materials can be followed in 4D visualization and that PrIDICT, compared to PICCS and ASD-POCS, shows superior reconstruction results and fewer artifacts in the periphery with dose in the order of biplane fluoroscopy. These results suggest that 4D intervention guidance can be realized with today's flat detector and gantry systems using the herein presented reconstruction scheme.

  4. 4D-Var Developement at GMAO

    NASA Technical Reports Server (NTRS)

    Pelc, Joanna S.; Todling, Ricardo; Akkraoui, Amal El

    2014-01-01

    The Global Modeling and Assimilation Offce (GMAO) is currently using an IAU-based 3D-Var data assimilation system. GMAO has been experimenting with a 3D-Var-hybrid version of its data assimilation system (DAS) for over a year now, which will soon become operational and it will rapidly progress toward a 4D-EnVar. Concurrently, the machinery to exercise traditional 4DVar is in place and it is desirable to have a comparison of the traditional 4D approach with the other available options, and evaluate their performance in the Goddard Earth Observing System (GEOS) DAS. This work will also explore the possibility for constructing a reduced order model (ROM) to make traditional 4D-Var computationally attractive for increasing model resolutions. Part of the research on ROM will be to search for a suitably acceptable space to carry on the corresponding reduction. This poster illustrates how the IAU-based 4D-Var assimilation compares with our currently used IAU-based 3D-Var.

  5. Constrained reconstructions for 4D intervention guidance

    NASA Astrophysics Data System (ADS)

    Kuntz, J.; Flach, B.; Kueres, R.; Semmler, W.; Kachelrieß, M.; Bartling, S.

    2013-05-01

    Image-guided interventions are an increasingly important part of clinical minimally invasive procedures. However, up to now they cannot be performed under 4D (3D + time) guidance due to the exceedingly high x-ray dose. In this work we investigate the applicability of compressed sensing reconstructions for highly undersampled CT datasets combined with the incorporation of prior images in order to yield low dose 4D intervention guidance. We present a new reconstruction scheme prior image dynamic interventional CT (PrIDICT) that accounts for specific image features in intervention guidance and compare it to PICCS and ASD-POCS. The optimal parameters for the dose per projection and the numbers of projections per reconstruction are determined in phantom simulations and measurements. In vivo experiments in six pigs are performed in a cone-beam CT; measured doses are compared to current gold-standard intervention guidance represented by a clinical fluoroscopy system. Phantom studies show maximum image quality for identical overall doses in the range of 14 to 21 projections per reconstruction. In vivo studies reveal that interventional materials can be followed in 4D visualization and that PrIDICT, compared to PICCS and ASD-POCS, shows superior reconstruction results and fewer artifacts in the periphery with dose in the order of biplane fluoroscopy. These results suggest that 4D intervention guidance can be realized with today’s flat detector and gantry systems using the herein presented reconstruction scheme.

  6. Primordial power spectrum from Planck

    SciTech Connect

    Hazra, Dhiraj Kumar; Shafieloo, Arman; Souradeep, Tarun E-mail: arman@apctp.org

    2014-11-01

    Using modified Richardson-Lucy algorithm we reconstruct the primordial power spectrum (PPS) from Planck Cosmic Microwave Background (CMB) temperature anisotropy data. In our analysis we use different combinations of angular power spectra from Planck to reconstruct the shape of the primordial power spectrum and locate possible features. Performing an extensive error analysis we found the dip near ℓ ∼ 750–850 represents the most prominent feature in the data. Feature near ℓ ∼ 1800–2000 is detectable with high confidence only in 217 GHz spectrum and is apparently consequence of a small systematic as described in the revised Planck 2013 papers. Fixing the background cosmological parameters and the foreground nuisance parameters to their best fit baseline values, we report that the best fit power law primordial power spectrum is consistent with the reconstructed form of the PPS at 2σ C.L. of the estimated errors (apart from the local features mentioned above). As a consistency test, we found the reconstructed primordial power spectrum from Planck temperature data can also substantially improve the fit to WMAP-9 angular power spectrum data (with respect to power-law form of the PPS) allowing an overall amplitude shift of ∼ 2.5%. In this context low-ℓ and 100 GHz spectrum from Planck which have proper overlap in the multipole range with WMAP data found to be completely consistent with WMAP-9 (allowing amplitude shift). As another important result of our analysis we do report the evidence of gravitational lensing through the reconstruction analysis. Finally we present two smooth form of the PPS containing only the important features. These smooth forms of PPS can provide significant improvements in fitting the data (with respect to the power law PPS) and can be helpful to give hints for inflationary model building.

  7. Primordial features and Planck polarization

    NASA Astrophysics Data System (ADS)

    Hazra, Dhiraj Kumar; Shafieloo, Arman; Smoot, George F.; Starobinsky, Alexei A.

    2016-09-01

    With the Planck 2015 Cosmic Microwave Background (CMB) temperature and polarization data, we search for possible features in the primordial power spectrum (PPS). We revisit the Wiggly Whipped Inflation (WWI) framework and demonstrate how generation of some particular primordial features can improve the fit to Planck data. WWI potential allows the scalar field to transit from a steeper potential to a nearly flat potential through a discontinuity either in potential or in its derivatives. WWI offers the inflaton potential parametrizations that generate a wide variety of features in the primordial power spectra incorporating most of the localized and non-local inflationary features that are obtained upon reconstruction from temperature and polarization angular power spectrum. At the same time, in a single framework it allows us to have a background parameter estimation with a nearly free-form primordial spectrum. Using Planck 2015 data, we constrain the primordial features in the context of Wiggly Whipped Inflation and present the features that are supported both by temperature and polarization. WWI model provides more than 13 improvement in χ2 fit to the data with respect to the best fit power law model considering combined temperature and polarization data from Planck and B-mode polarization data from BICEP and Planck dust map. We use 2-4 extra parameters in the WWI model compared to the featureless strict slow roll inflaton potential. We find that the differences between the temperature and polarization data in constraining background cosmological parameters such as baryon density, cold dark matter density are reduced to a good extent if we use primordial power spectra from WWI. We also discuss the extent of bispectra obtained from the best potentials in arbitrary triangular configurations using the BI-spectra and Non-Gaussianity Operator (BINGO).

  8. Interactive animation of 4D performance capture.

    PubMed

    Casas, Dan; Tejera, Margara; Guillemaut, Jean-Yves; Hilton, Adrian

    2013-05-01

    A 4D parametric motion graph representation is presented for interactive animation from actor performance capture in a multiple camera studio. The representation is based on a 4D model database of temporally aligned mesh sequence reconstructions for multiple motions. High-level movement controls such as speed and direction are achieved by blending multiple mesh sequences of related motions. A real-time mesh sequence blending approach is introduced, which combines the realistic deformation of previous nonlinear solutions with efficient online computation. Transitions between different parametric motion spaces are evaluated in real time based on surface shape and motion similarity. Four-dimensional parametric motion graphs allow real-time interactive character animation while preserving the natural dynamics of the captured performance.

  9. Nondipole Effects in Xe 4d Photoemission

    SciTech Connect

    Hemmers, O; Guillemin, R; Wolska, A; Lindle, D W; Rolles, D; Cheng, K T; Johnson, W R; Zhou, H L; Manson, S T

    2004-07-14

    We measured the nondipole parameters for the spin-orbit doublets Xe 4d{sub 5/2} and Xe 4d{sub 3/2} over a photon-energy range from 100 eV to 250 eV at beamline 8.0.1.3 of the Advanced Light Source at the Lawrence Berkeley National Laboratory. Significant nondipole effects are found at relatively low energies as a result of Cooper minima in dipole channels and interchannel coupling in quadrupole channels. Most importantly, sharp disagreement between experiment and theory, when otherwise excellent agreement was expected, has provided the first evidence of satellite two-electron quadrupole photoionization transitions, along with their crucial importance for a quantitatively accurate theory.

  10. Interactive animation of 4D performance capture.

    PubMed

    Casas, Dan; Tejera, Margara; Guillemaut, Jean-Yves; Hilton, Adrian

    2013-05-01

    A 4D parametric motion graph representation is presented for interactive animation from actor performance capture in a multiple camera studio. The representation is based on a 4D model database of temporally aligned mesh sequence reconstructions for multiple motions. High-level movement controls such as speed and direction are achieved by blending multiple mesh sequences of related motions. A real-time mesh sequence blending approach is introduced, which combines the realistic deformation of previous nonlinear solutions with efficient online computation. Transitions between different parametric motion spaces are evaluated in real time based on surface shape and motion similarity. Four-dimensional parametric motion graphs allow real-time interactive character animation while preserving the natural dynamics of the captured performance. PMID:23492379

  11. Planck Surveyor On Its Way to Orbit

    ScienceCinema

    Borrill, Julian

    2016-07-12

    An Ariane 5 rocket carried the Planck Surveyor and a companion satellite into space May 14, 2009 from the European Space Agency (ESA) base on the northwest coast of South America. Once in orbit beyond the moon, Planck will produce the most accurate measurements ever made of the relic radiation from the big bang, plus the largest set of CMB data ever recorded. Berkeley Labs long and continuing involvement with Planck began when George Smoot of the Physics Division proposed Plancks progenitor to ESA and continues with preparations for ongoing data analysis for the U.S. Planck team at NERSC, led by Julian Borrill, co-leader of the Computational Cosmology Center.

  12. Planck Surveyor On Its Way to Orbit

    ScienceCinema

    None

    2016-07-12

    An Ariane 5 rocket carried the Planck Surveyor and a companion satellite into space May 14, 2009 from the European Space Agency (ESA) base on the northwest coast of South America. Once in orbit beyond the moon, Planck will produce the most accurate measurements ever made of the relic radiation from the big bang, plus the largest set of CMB data ever recorded. Berkeley Labs long and continuing involvement with Planck began when George Smoot of the Physics Division proposed Plancks progenitor to ESA and continues with preparations for ongoing data analysis for the U.S. Planck team at NERSC, led by Julian Borrill, co-leader of the Computational Cosmology Center

  13. Planck Surveyor On Its Way to Orbit

    SciTech Connect

    2009-05-14

    An Ariane 5 rocket carried the Planck Surveyor and a companion satellite into space May 14, 2009 from the European Space Agency (ESA) base on the northwest coast of South America. Once in orbit beyond the moon, Planck will produce the most accurate measurements ever made of the relic radiation from the big bang, plus the largest set of CMB data ever recorded. Berkeley Labs long and continuing involvement with Planck began when George Smoot of the Physics Division proposed Plancks progenitor to ESA and continues with preparations for ongoing data analysis for the U.S. Planck team at NERSC, led by Julian Borrill, co-leader of the Computational Cosmology Center

  14. Planck Surveyor On Its Way to Orbit

    SciTech Connect

    Borrill, Julian

    2009-01-01

    An Ariane 5 rocket carried the Planck Surveyor and a companion satellite into space May 14, 2009 from the European Space Agency (ESA) base on the northwest coast of South America. Once in orbit beyond the moon, Planck will produce the most accurate measurements ever made of the relic radiation from the big bang, plus the largest set of CMB data ever recorded. Berkeley Labs long and continuing involvement with Planck began when George Smoot of the Physics Division proposed Plancks progenitor to ESA and continues with preparations for ongoing data analysis for the U.S. Planck team at NERSC, led by Julian Borrill, co-leader of the Computational Cosmology Center.

  15. Abdominal and pancreatic motion correlation using 4D CT, 4D transponders, and a gating belt.

    PubMed

    Betancourt, Ricardo; Zou, Wei; Plastaras, John P; Metz, James M; Teo, Boon-Keng; Kassaee, Alireza

    2013-01-01

    The correlation between the pancreatic and external abdominal motion due to respiration was investigated on two patients. These studies utilized four dimensional computer tomography (4D CT), a four dimensional (4D) electromagnetic transponder system, and a gating belt system. One 4D CT study was performed during simulation to quantify the pancreatic motion using computer tomography images at eight breathing phases. The motion under free breathing and breath-hold were analyzed for the 4D electromagnetic transponder system and the gating belt system during treatment. A linear curve was fitted for all data sets and correlation factors were evaluated between the 4D electromagnetic transponder system and the gating belt system data. The 4D CT study demonstrated a modest correlation between the external marker and the pancreatic motion with R-square values larger than 0.8 for the inferior-superior (inf-sup). Then, the relative pressure from the belt gating system correlated well with the 4D electromagnetic transponder system's motion in the anterior-posterior (ant-post) and the inf-post directions. These directions have a correlation value of -0.93 and 0.76, while the lateral only had a 0.03 correlation coefficient. Based on our limited study, external surrogates can be used as predictors of the pancreatic motion in the inf-sup and the ant-post directions. Although there is a low correlation on the lateral direction, its motion is significantly shorter. In conclusion, an appropriate treatment delivery can be used for pancreatic cancer when an internal tracking system, such as the 4D electromagnetic transponder system, is unavailable. PMID:23652242

  16. Abdominal and pancreatic motion correlation using 4D CT, 4D transponders, and a gating belt.

    PubMed

    Betancourt, Ricardo; Zou, Wei; Plastaras, John P; Metz, James M; Teo, Boon-Keng; Kassaee, Alireza

    2013-05-06

    The correlation between the pancreatic and external abdominal motion due to respiration was investigated on two patients. These studies utilized four dimensional computer tomography (4D CT), a four dimensional (4D) electromagnetic transponder system, and a gating belt system. One 4D CT study was performed during simulation to quantify the pancreatic motion using computer tomography images at eight breathing phases. The motion under free breathing and breath-hold were analyzed for the 4D electromagnetic transponder system and the gating belt system during treatment. A linear curve was fitted for all data sets and correlation factors were evaluated between the 4D electromagnetic transponder system and the gating belt system data. The 4D CT study demonstrated a modest correlation between the external marker and the pancreatic motion with R-square values larger than 0.8 for the inferior-superior (inf-sup). Then, the relative pressure from the belt gating system correlated well with the 4D electromagnetic transponder system's motion in the anterior-posterior (ant-post) and the inf-post directions. These directions have a correlation value of -0.93 and 0.76, while the lateral only had a 0.03 correlation coefficient. Based on our limited study, external surrogates can be used as predictors of the pancreatic motion in the inf-sup and the ant-post directions. Although there is a low correlation on the lateral direction, its motion is significantly shorter. In conclusion, an appropriate treatment delivery can be used for pancreatic cancer when an internal tracking system, such as the 4D electromagnetic transponder system, is unavailable.

  17. Inflationary paradigm after Planck 2013

    NASA Astrophysics Data System (ADS)

    Guth, Alan H.; Kaiser, David I.; Nomura, Yasunori

    2014-06-01

    Models of cosmic inflation posit an early phase of accelerated expansion of the universe, driven by the dynamics of one or more scalar fields in curved spacetime. Though detailed assumptions about fields and couplings vary across models, inflation makes specific, quantitative predictions for several observable quantities, such as the flatness parameter (Ωk = 1 - Ω) and the spectral tilt of primordial curvature perturbations (ns - 1 = dln ⁡PR / dln ⁡ k), among others-predictions that match the latest observations from the Planck satellite to very good precision. In the light of data from Planck as well as recent theoretical developments in the study of eternal inflation and the multiverse, we address recent criticisms of inflation by Ijjas, Steinhardt, and Loeb. We argue that their conclusions rest on several problematic assumptions, and we conclude that cosmic inflation is on a stronger footing than ever before.

  18. The Planck Mission: Early Results

    SciTech Connect

    Marco Bersanelli

    2012-03-07

    The ESA Planck space mission, launched on May 14, 2009, is dedicated to high precision measurements of the cosmic microwave background (CMB), the first light of the universe, both in temperature and polarization. The satellite observes the full sky from a far-Earth orbit with two cryogenic instruments in the 30-850 GHz range at the focal plane of a 1.5-meter telescope. The primary objective of Planck is to measure with unprecedented precision the key cosmological parameters and to provide accurate tests of physics in the early universe. Planck has recently completed the fifth full-sky survey. The data analysis is underway. The first cosmology results are expected in early 2013 while a number of astrophysical results have been recently delivered to the community, including galactic and extragalactic astrophysics and a rich catalogue of radio and infrared sources. These results demonstrate the excellent in-orbit performance of the instruments and give excellent prospects for the forthcoming cosmological results.

  19. Active origami by 4D printing

    NASA Astrophysics Data System (ADS)

    Ge, Qi; Dunn, Conner K.; Qi, H. Jerry; Dunn, Martin L.

    2014-09-01

    Recent advances in three dimensional (3D) printing technology that allow multiple materials to be printed within each layer enable the creation of materials and components with precisely controlled heterogeneous microstructures. In addition, active materials, such as shape memory polymers, can be printed to create an active microstructure within a solid. These active materials can subsequently be activated in a controlled manner to change the shape or configuration of the solid in response to an environmental stimulus. This has been termed 4D printing, with the 4th dimension being the time-dependent shape change after the printing. In this paper, we advance the 4D printing concept to the design and fabrication of active origami, where a flat sheet automatically folds into a complicated 3D component. Here we print active composites with shape memory polymer fibers precisely printed in an elastomeric matrix and use them as intelligent active hinges to enable origami folding patterns. We develop a theoretical model to provide guidance in selecting design parameters such as fiber dimensions, hinge length, and programming strains and temperature. Using the model, we design and fabricate several active origami components that assemble from flat polymer sheets, including a box, a pyramid, and two origami airplanes. In addition, we directly print a 3D box with active composite hinges and program it to assume a temporary flat shape that subsequently recovers to the 3D box shape on demand.

  20. Planck 2015 results. XXI. The integrated Sachs-Wolfe effect

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Casaponsa, B.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Fernandez-Cobos, R.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Ilić, S.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Langer, M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Ma, Y.-Z.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marcos-Caballero, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Schaefer, B. M.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, F.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    This paper presents a study of the integrated Sachs-Wolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the large-scale time-evolving gravitational potential is probed from different perspectives. The CMB is cross-correlated with different large-scale structure (LSS) tracers: radio sources from the NVSS catalogue; galaxies from the optical SDSS and the infrared WISE surveys; and the Planck 2015 convergence lensing map. The joint cross-correlation of the CMB with the tracers yields a detection at 4σ where most of the signal-to-noise is due to the Planck lensing and the NVSS radio catalogue. In fact, the ISW effect is detected from the Planck data only at ≈3σ (through the ISW-lensing bispectrum), which is similar to the detection level achieved by combining the cross-correlation signal coming from all the galaxy catalogues mentioned above. We study the ability of the ISW effect to place constraints on the dark-energy parameters; in particular, we show that ΩΛ is detected at more than 3σ. This cross-correlation analysis is performed only with the Planck temperature data, since the polarization scales available in the 2015 release do not permit significant improvement of the CMB-LSS cross-correlation detectability. Nevertheless, the Planck polarization data are used to study the anomalously large ISW signal previously reported through the aperture photometry on stacked CMB features at the locations of known superclusters and supervoids, which is in conflict with ΛCDM expectations. We find that the current Planck polarization data do not exclude that this signal could be caused by the ISW effect. In addition, the stacking of the Planck lensing map on the locations of superstructures exhibits a positive cross-correlation with these large-scale structures. Finally, we have improved our previous reconstruction of the ISW temperature fluctuations by combining the

  1. The Planck Catalogue of High-z source candidates

    NASA Astrophysics Data System (ADS)

    Montier, Ludovic

    2015-08-01

    The Planck satellite has provided the first FIR/submm all-sky survey with a sensitivity allowing us to identify the rarest, most luminous high-z dusty star-forming sources on the sky. It opens a new window on these extreme star-forming systems at redshift above 1.5, providing a powerful laboratory to study the mechanisms of galaxy evolution and enrichment in the frame of the large scale structure growth.I will describe how the Planck catalogue of high-z source candidates (PHz, Planck 2015 in prep.) has been built and charcaterized over 25% of the sky by selecting the brightest red submm sources at a 5' resolution. Follow-up observations with Herschel/SPIRE over 228 Planck candidates have shown that 93% of these candidates are actually overdensities of red sources with SEDs peaking at 350um (Planck Int. results. XXVII 2014). Complementarily to this population of objects, 12 Planck high-z candidates have been identified as strongly lensed star forming galaxies at redshift lying between 2.2 and 3.6 (Canameras et al 2015 subm.), with flux densities larger than 400 mJy up to 1 Jy at 350um, and strong magnification factors. These Planck lensed star-forming galaxies are the rarest brightest lensed in the submm range, providing a unique opportunity to extend the exploration of the star-forming system in this range of mass and redshift.I will detail further a specific analysis performed on a proto-cluster candidate, PHz G95.5-61.6, identified as a double structure at z=1.7 and z=2.03, using an extensive follow-up program (Flores-Cacho et al 2015 subm.). This is the first Planck proto-cluster candidate with spectroscopic confirmation, which opens a new field of statistical analysis about the evolution of dusty star-forming galaxies in such accreting structures.I will finally discuss how the PHz catalogue may help to answer some of the fundamental questions like: At what cosmic epoch did massive galaxy clusters form most of their stars? Is star formation more or less vigorous

  2. Advances in 4D radiation therapy for managing respiration: part II - 4D treatment planning.

    PubMed

    Rosu, Mihaela; Hugo, Geoffrey D

    2012-12-01

    The development of 4D CT imaging technology made possible the creation of patient models that are reflective of respiration-induced anatomical changes by adding a temporal dimension to the conventional 3D, spatial-only, patient description. This had opened a new venue for treatment planning and radiation delivery, aimed at creating a comprehensive 4D radiation therapy process for moving targets. Unlike other breathing motion compensation strategies (e.g. breath-hold and gating techniques), 4D radiotherapy assumes treatment delivery over the entire respiratory cycle - an added bonus for both patient comfort and treatment time efficiency. The time-dependent positional and volumetric information holds the promise for optimal, highly conformal, radiotherapy for targets experiencing movements caused by respiration, with potentially elevated dose prescriptions and therefore higher cure rates, while avoiding the uninvolved nearby structures. In this paper, the current state of the 4D treatment planning is reviewed, from theory to the established practical routine. While the fundamental principles of 4D radiotherapy are well defined, the development of a complete, robust and clinically feasible process still remains a challenge, imposed by limitations in the available treatment planning and radiation delivery systems.

  3. Advances in 4D Radiation Therapy for Managing Respiration: Part II – 4D Treatment Planning

    PubMed Central

    Rosu, Mihaela; Hugo, Geoffrey D.

    2014-01-01

    The development of 4D CT imaging technology made possible the creation of patient models that are reflective of respiration-induced anatomical changes by adding a temporal dimension to the conventional 3D, spatial-only, patient description. This had opened a new venue for treatment planning and radiation delivery, aimed at creating a comprehensive 4D radiation therapy process for moving targets. Unlike other breathing motion compensation strategies (e.g. breath-hold and gating techniques), 4D radiotherapy assumes treatment delivery over the entire respiratory cycle – an added bonus for both patient comfort and treatment time efficiency. The time-dependent positional and volumetric information holds the promise for optimal, highly conformal, radiotherapy for targets experiencing movements caused by respiration, with potentially elevated dose prescriptions and therefore higher cure rates, while avoiding the uninvolved nearby structures. In this paper, the current state of the 4D treatment planning is reviewed, from theory to the established practical routine. While the fundamental principles of 4D radiotherapy are well defined, the development of a complete, robust and clinically feasible process still remains a challenge, imposed by limitations in the available treatment planning and radiation delivery systems. PMID:22796324

  4. ICT4D: A Computer Science Perspective

    NASA Astrophysics Data System (ADS)

    Sutinen, Erkki; Tedre, Matti

    The term ICT4D refers to the opportunities of Information and Communication Technology (ICT) as an agent of development. Research in that field is often focused on evaluating the feasibility of existing technologies, mostly of Western or Far East Asian origin, in the context of developing regions. A computer science perspective is complementary to that agenda. The computer science perspective focuses on exploring the resources, or inputs, of a particular context and on basing the design of a technical intervention on the available resources, so that the output makes a difference in the development context. The modus operandi of computer science, construction, interacts with evaluation and exploration practices. An analysis of a contextualized information technology curriculum of Tumaini University in southern Tanzania shows the potential of the computer science perspective for designing meaningful information and communication technology for a developing region.

  5. 4D Clinical Imaging for Dynamic CAD

    PubMed Central

    McIntyre, Frederick

    2013-01-01

    A basic 4D imaging system to capture the jaw motion has been developed that produces high resolution 3D surface data. Fluorescent microspheres are brushed onto the areas of the upper and the lower arches to be imaged, producing a high-contrast random optical pattern. A hand-held imaging device operated at about 10 cm from the mouth captures time-based perspective images of the fluorescent areas. Each set of images, containing both upper and the lower arch data, is converted to a 3d point mesh using photogrammetry, thereby providing an instantaneous relative jaw position. Eight 3d positions per second are captured. Using one of the 3d frames as a reference, incremental transforms are derived to express the free body motion of the mandible. Conventional 3d models of the dentition are directly registered to the reference frame, allowing them to be animated using the derived transforms. PMID:24082882

  6. Soft Route to 4D Tomography.

    PubMed

    Taillandier-Thomas, Thibault; Roux, Stéphane; Hild, François

    2016-07-01

    Based on the assumption that the time evolution of a sample observed by computed tomography requires many less parameters than the definition of the microstructure itself, it is proposed to reconstruct these changes based on the initial state (using computed tomography) and very few radiographs acquired at fixed intervals of time. This Letter presents a proof of concept that for a fatigue cracked sample its kinematics can be tracked from no more than two radiographs in situations where a complete 3D view would require several hundreds of radiographs. This 2 order of magnitude gain opens the way to a "computed" 4D tomography, which complements the recent progress achieved in fast or ultrafast computed tomography, which is based on beam brightness, detector sensitivity, and signal acquisition technologies.

  7. Soft Route to 4D Tomography

    NASA Astrophysics Data System (ADS)

    Taillandier-Thomas, Thibault; Roux, Stéphane; Hild, François

    2016-07-01

    Based on the assumption that the time evolution of a sample observed by computed tomography requires many less parameters than the definition of the microstructure itself, it is proposed to reconstruct these changes based on the initial state (using computed tomography) and very few radiographs acquired at fixed intervals of time. This Letter presents a proof of concept that for a fatigue cracked sample its kinematics can be tracked from no more than two radiographs in situations where a complete 3D view would require several hundreds of radiographs. This 2 order of magnitude gain opens the way to a "computed" 4D tomography, which complements the recent progress achieved in fast or ultrafast computed tomography, which is based on beam brightness, detector sensitivity, and signal acquisition technologies.

  8. German science. Max Planck charts new path.

    PubMed

    Koenig, R

    2000-06-01

    Germany's premier basic research organization, the Max Planck Society, released a long-awaited blueprint for change during its annual meeting this week, recommending that the society's nearly 3000 scientists embrace more interdisciplinary and international projects in a range of new research priorities. The report, called Max Planck 2000-Plus, is the product of an 18-month-long internal review. Its recommendations were formulated by some two dozen Max Planck researchers and administrators, who sought input from every institute.

  9. Planck 2013 results. XXXI. Consistency of the Planck data

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Battaner, E.; Benabed, K.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Burigana, C.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Dupac, X.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Galeotta, S.; Ganga, K.; Giard, M.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Keihänen, E.; Keskitalo, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lawrence, C. R.; Leonardi, R.; León-Tavares, J.; Lesgourgues, J.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maino, D.; Mandolesi, N.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Pagano, L.; Pajot, F.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, D.; Pearson, T. J.; Perdereau, O.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Pratt, G. W.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Ristorcelli, I.; Rocha, G.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Scott, D.; Stolyarov, V.; Sudiwala, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; White, S. D. M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2014-11-01

    The Planck design and scanning strategy provide many levels of redundancy that can be exploited to provide tests of internal consistency. One of the most important is the comparison of the 70 GHz (amplifier) and 100 GHz (bolometer) channels. Based on different instrument technologies, with feeds located differently in the focal plane, analysed independently by different teams using different software, and near the minimum of diffuse foreground emission, these channels are in effect two different experiments. The 143 GHz channel has the lowest noise level on Planck, and is near the minimum of unresolved foreground emission. In this paper, we analyse the level of consistency achieved in the 2013 Planck data. We concentrate on comparisons between the 70, 100, and 143 GHz channel maps and power spectra, particularly over the angular scales of the first and second acoustic peaks, on maps masked for diffuse Galactic emission and for strong unresolved sources. Difference maps covering angular scales from 8° to 15' are consistent with noise, and show no evidence of cosmic microwave background structure. Including small but important corrections for unresolved-source residuals, we demonstrate agreement (measured by deviation of the ratio from unity) between 70 and 100 GHz power spectra averaged over 70 ≤ ℓ ≤ 390 at the 0.8% level, and agreement between 143 and 100 GHz power spectra of 0.4% over the same ℓ range. These values are within and consistent with the overall uncertainties in calibration given in the Planck 2013 results. We also present results based on the 2013 likelihood analysis showing consistency at the 0.35% between the 100, 143, and 217 GHz power spectra. We analyse calibration procedures and beams to determine what fraction of these differences can be accounted for by known approximations or systematicerrors that could be controlled even better in the future, reducing uncertainties still further. Several possible small improvements are described

  10. Triangulum galaxy viewed by Planck

    NASA Astrophysics Data System (ADS)

    De Paolis, F.; Gurzadyan, V. G.; Nucita, A. A.; Chemin, L.; Qadir, A.; Kashin, A. L.; Khachatryan, H. G.; Sargsyan, S.; Yegorian, G.; Ingrosso, G.; Jetzer, Ph.; Vetrugno, D.

    2016-09-01

    We used Planck data to study the M 33 galaxy and find a substantial temperature asymmetry with respect to its minor axis projected onto the sky plane. This temperature asymmetry correlates well with the HI velocity field at 21 cm, at least within a galactocentric distance of 0.5°, and it is found to extend up to about 3° from the galaxy center. We conclude that the revealed effect, that is, the temperature asymmetry and its extension, implies that we detected the differential rotation of the M 33 galaxy and of its extended baryonic halo.

  11. Millikan's measurement of Planck's constant

    NASA Astrophysics Data System (ADS)

    Franklin, Allan

    2013-12-01

    Robert Millikan is famous for measuring the charge of the electron. His result was better than any previous measurement and his method established that there was a fundamental unit of charge, or charge quantization. He is less well-known for his measurement of Planck's constant, although, as discussed below, he is often mistakenly given credit for providing significant evidence in support of Einstein's photon theory of light.1 His Nobel Prize citation was "for his work on the elementary electric charge of electricity and the photoelectric effect," an indication of the significance of his work on the photoelectric effect.

  12. Opening the Black Box of ICT4D: Advancing Our Understanding of ICT4D Partnerships

    ERIC Educational Resources Information Center

    Park, Sung Jin

    2013-01-01

    The term, Information and Communication Technologies for Development (ICT4D), pertains to programs or projects that strategically use ICTs (e.g. mobile phones, computers, and the internet) as a means toward the socio-economic betterment for the poor in developing contexts. Gaining the political and financial support of the international community…

  13. The Polarization of the CMB with Planck

    NASA Astrophysics Data System (ADS)

    Rocha, Graca; Planck Collaboration

    2016-06-01

    In this talk I will give an overview of Planck data and Cosmological results focusing on the analysis of polarized data. I will present new insights into the polarization of foregrounds rendered by the Planck satelite and an account of current constraints on the optical depth due to reionization, τ, and the scalar to tensor ratio, r.

  14. Planck intermediate results. XXIX. All-sky dust modelling with Planck, IRAS, and WISE observations

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Alves, M. I. R.; Aniano, G.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Couchot, F.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Dickinson, C.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Draine, B. T.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Falgarone, E.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Ghosh, T.; Giard, M.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gregorio, A.; Gruppuso, A.; Guillet, V.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Holmes, W. A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Natoli, P.; Nørgaard-Nielsen, H. U.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Pasian, F.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Pratt, G. W.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ristorcelli, I.; Rocha, G.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Scott, D.; Spencer, L. D.; Stolyarov, V.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Ysard, N.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-02-01

    We present all-sky modelling of the high resolution Planck, IRAS, and WISE infrared (IR) observations using the physical dust model presented by Draine & Li in 2007 (DL, ApJ, 657, 810). We study the performance and results of this model, and discuss implications for future dust modelling. The present work extends the DL dust modelling carried out on nearby galaxies using Herschel and Spitzer data to Galactic dust emission. We employ the DL dust model to generate maps of the dust mass surface density ΣMd, the dust optical extinction AV, and the starlight intensity heating the bulk of the dust, parametrized by Umin. The DL model reproduces the observed spectral energy distribution (SED) satisfactorily over most of the sky, with small deviations in the inner Galactic disk and in low ecliptic latitude areas, presumably due to zodiacal light contamination. In the Andromeda galaxy (M31), the present dust mass estimates agree remarkably well (within 10%) with DL estimates based on independent Spitzer and Herschel data. We compare the DL optical extinction AV for the diffuse interstellar medium (ISM) with optical estimates for approximately 2 × 105 quasi-stellar objects (QSOs) observed inthe Sloan Digital Sky Survey (SDSS). The DL AV estimates are larger than those determined towards QSOs by a factor of about 2, which depends on Umin. The DL fitting parameter Umin, effectively determined by the wavelength where the SED peaks, appears to trace variations in the far-IR opacity of the dust grains per unit AV, and not only in the starlight intensity. These results show that some of the physical assumptions of the DL model will need to be revised. To circumvent the model deficiency, we propose an empirical renormalization of the DL AV estimate, dependent of Umin, which compensates for the systematic differences found with QSO observations. This renormalization, made to match the AV estimates towards QSOs, also brings into agreement the DL AV estimates with those derived for

  15. 4-D ultrafast shear-wave imaging.

    PubMed

    Gennisson, Jean-Luc; Provost, Jean; Deffieux, Thomas; Papadacci, Clément; Imbault, Marion; Pernot, Mathieu; Tanter, Mickael

    2015-06-01

    Over the last ten years, shear wave elastography (SWE) has seen considerable development and is now routinely used in clinics to provide mechanical characterization of tissues to improve diagnosis. The most advanced technique relies on the use of an ultrafast scanner to generate and image shear waves in real time in a 2-D plane at several thousands of frames per second. We have recently introduced 3-D ultrafast ultrasound imaging to acquire with matrix probes the 3-D propagation of shear waves generated by a dedicated radiation pressure transducer in a single acquisition. In this study, we demonstrate 3-D SWE based on ultrafast volumetric imaging in a clinically applicable configuration. A 32 × 32 matrix phased array driven by a customized, programmable, 1024-channel ultrasound system was designed to perform 4-D shear-wave imaging. A matrix phased array was used to generate and control in 3-D the shear waves inside the medium using the acoustic radiation force. The same matrix array was used with 3-D coherent plane wave compounding to perform high-quality ultrafast imaging of the shear wave propagation. Volumetric ultrafast acquisitions were then beamformed in 3-D using a delay-and-sum algorithm. 3-D volumetric maps of the shear modulus were reconstructed using a time-of-flight algorithm based on local multiscale cross-correlation of shear wave profiles in the three main directions using directional filters. Results are first presented in an isotropic homogeneous and elastic breast phantom. Then, a full 3-D stiffness reconstruction of the breast was performed in vivo on healthy volunteers. This new full 3-D ultrafast ultrasound system paves the way toward real-time 3-D SWE. PMID:26067040

  16. WMAP OBSERVATIONS OF PLANCK ESZ CLUSTERS

    SciTech Connect

    Ma Yinzhe; Hinshaw, Gary; Scott, Douglas

    2013-07-10

    We examine the Sunyaev-Zeldovich (SZ) effect in the seven year Wilkinson Microwave Anisotropy Probe (WMAP) data by cross-correlating it with the Planck Early-release Sunyaev-Zeldovich catalog. Our analysis proceeds in two parts. We first perform a stacking analysis in which the filtered WMAP data are averaged at the locations of the 175 Planck clusters. We then perform a regression analysis to compare the mean amplitude of the SZ signal, Y{sub 500}, in the WMAP data to the corresponding amplitude in the Planck data. The aggregate Planck clusters are detected in the seven year WMAP data with a signal-to-noise ratio of 16.3. In the regression analysis, we find that the SZ amplitude measurements agree to better than 25%: a = 1.23 {+-} 0.18 for the fit Y{sup wmap}{sub 500}= aY{sup planck}{sub 500}.

  17. Dark radiation sterile neutrino candidates after Planck data

    SciTech Connect

    Valentino, Eleonora Di; Melchiorri, Alessandro; Mena, Olga E-mail: alessandro.melchiorri@roma1.infn.it

    2013-11-01

    Recent Cosmic Microwave Background (CMB) results from the Planck satellite, combined with previous CMB data and Hubble constant measurements from the Hubble Space Telescope, provide a constraint on the effective number of relativistic degrees of freedom 3.62{sup +0.50}{sub −0.48} at 95% CL. New Planck data provide a unique opportunity to place limits on models containing relativistic species at the decoupling epoch. We present here the bounds on sterile neutrino models combining Planck data with galaxy clustering information. Assuming N{sub eff} active plus sterile massive neutrino species, in the case of a Planck+WP+HighL+HST analysis we find m{sub ν,} {sub sterile}{sup eff} < 0.36 eV and 3.14 < N{sub eff} < 4.15 at 95% CL, while using Planck+WP+HighL data in combination with the full shape of the galaxy power spectrum from the Baryon Oscillation Spectroscopic Survey BOSS Data Relase 9 measurements, we find that 3.30 < N{sub eff} < 4.43 and m{sub ν,} {sub sterile}{sup eff} < 0.33 eV both at 95% CL with the three active neutrinos having the minimum mass allowed in the normal hierarchy scheme, i.e. ∑m{sub ν} ∼ 0.06 eV. These values compromise the viability of the (3+2) massive sterile neutrino models for the parameter region indicated by global fits of neutrino oscillation data. Within the (3+1) massive sterile neutrino scenario, we find m{sub ν,} {sub sterile}{sup eff} < 0.34 eV at 95% CL. While the existence of one extra sterile massive neutrino state is compatible with current oscillation data, the values for the sterile neutrino mass preferred by oscillation analyses are significantly higher than the current cosmological bound. We review as well the bounds on extended dark sectors with additional light species based on the latest Planck CMB observations.

  18. 17 CFR 260.4d-8 - Content.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Content. 260.4d-8 Section 260.4d-8 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Rules Under Section 304 § 260.4d-8 Content. (a)...

  19. 17 CFR 260.4d-8 - Content.

    Code of Federal Regulations, 2012 CFR

    2005-04-01

    ... 17 Commodity and Securities Exchanges 3 2005-04-01 2005-04-01 false Content. 260.4d-8 Section 260.4d-8 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Rules Under Section 304 § 260.4d-8 Content. (a)...

  20. 17 CFR 260.4d-8 - Content.

    Code of Federal Regulations, 2013 CFR

    2000-04-01

    ... 17 Commodity and Securities Exchanges 3 2000-04-01 2000-04-01 false Content. 260.4d-8 Section 260.4d-8 Commodity and Securities Exchanges GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Rules Under Section 304 § 260.4d-8 Content. (a) Each application for an order under section 304(d)...

  1. 17 CFR 260.4d-8 - Content.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Content. 260.4d-8 Section 260.4d-8 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Rules Under Section 304 § 260.4d-8 Content. (a)...

  2. 17 CFR 260.4d-8 - Content.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Content. 260.4d-8 Section 260.4d-8 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Rules Under Section 304 § 260.4d-8 Content. (a)...

  3. 17 CFR 260.4d-8 - Content.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Content. 260.4d-8 Section 260.4d-8 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Rules Under Section 304 § 260.4d-8 Content. (a)...

  4. 76 FR 55814 - 2,4-D; Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... AGENCY 40 CFR Part 180 2,4-D; Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This regulation establishes tolerances for residues of 2,4-D in or on teff, bran... 180.142 be amended by establishing a tolerance for residues of the herbicide 2,4-D...

  5. 17 CFR 260.4d-8 - Content.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Content. 260.4d-8 Section 260.4d-8 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Rules Under Section 304 § 260.4d-8 Content. (a)...

  6. The Planck Mission and its Products

    NASA Astrophysics Data System (ADS)

    Tauber, Jan A.

    2015-08-01

    Planck (http://www.esa.int/Planck) is an astronomical satellite part of the Scientific Programme of the European Space Agency, which was designed to image the anisotropies of the Cosmic Microwave Background (CMB) over the whole sky, with unprecedented sensitivity and angular resolution. Planck is a major source of information relevant to many cosmological and astrophysical issues. The ability to measure to high accuracy the angular power spectrum of the CMB fluctuations allows the determination of fundamental cosmological parameters with an uncertainty better than a percent. In addition to the main cosmological goals of the mission, the Planck sky survey can be used to study in detail the very sources of emission which "contaminate" the signal due to the CMB, and will result in a wealth of information on the properties of extragalactic sources, and on the dust and gas in our own galaxy.Planck was launched together with Herschel on 14 May 2009. Its payload surveyed the sky continuously between July 2009 and October 2013. In January 2011 the first Planck data product (the Early Release Compact Source Catalogue) and scientific results were released to the public. The second data release took place on March 2013, and included maps of the whole sky at nine frequencies as well as maps of the major physical emission components. The third data release is taking place between February and May 2015, and includes all the data acquired by Planck.I will present - on behalf of the Planck Collaboration - a very brief overview of the Planck mission, its scientific objectives, and also briefly describe its most recent scientific results. Next, I will concentrate on describing the Planck data products that have been publicly released, and how they can serve a wide community of users. This talk is intended to be an appropriate introduction to the IAU GA Focus Meeting “The Legacy of Planck”.

  7. Planck data and ultralight axions

    NASA Astrophysics Data System (ADS)

    Csáki, Csaba; Kaloper, Nemanja; Terning, John

    2015-06-01

    We examine the effects of photon-axion mixing on the CMB. We show that if there are very underdense regions between us and the last scattering surface which contain coherent magnetic fields (whose strength can be orders of magnitude weaker than the current bounds), then photon-axion mixing can induce observable deviations in the CMB spectrum. Specifically, we show that the mixing can give rise to non-thermal spots on the CMB sky. As an example we consider the well known CMB cold spot, which according to the Planck data has a weak distortion from a black body spectrum, that can be fit by our model. While this explanation of the non-thermality in the region of the cold spot is quite intriguing, photon-axion oscillations do not explain the temperature of the cold spot itself. Nevertheless we demonstrate the possible sensitivity of the CMB to ultralight axions which could be exploited by observers.

  8. Predicting a prior for Planck

    SciTech Connect

    Hertog, Thomas

    2014-02-01

    The quantum state of the universe combined with the structure of the landscape potential implies a prior that specifies predictions for observations. We compute the prior for CMB related observables given by the no-boundary wave function (NBWF) in a landscape model that includes a range of inflationary patches representative of relatively simple single-field models. In this landscape the NBWF predicts our classical cosmological background emerges from a region of eternal inflation associated with a plateau-like potential. The spectra of primordial fluctuations on observable scales are characteristic of concave potentials, in excellent agreement with the Planck data. By contrast, alternative theories of initial conditions that strongly favor inflation at high values of the potential are disfavored by observations in this landscape.

  9. Countability of Planck Boxes in Quantum Branching Models

    NASA Astrophysics Data System (ADS)

    Berezin, Alexander A.

    2002-04-01

    Two popular paradigms of cosmological quantum branching are Many World (MW) model of parallel universes (Everett, Deutsch) and inflationary quantum foam (IQF) model (Guth, Linde). Taking Planck L,T units as physically smallest, our Big Bang miniverse with size 10E28 cm and duration 10E18 sec has some 10E244 (N) elementary 4D Planck Boxes (PB) in its entire spacetime history. Using combinatorics, N! (about 10E10E247) is upper estimate for number of all possible 4D states, i.e. scale of "eternal return" (ER; Nietzsche, Eliade) for such miniverses. To count all states in full Megaverse (all up and down branches of infinite tree of all MW and/or IQF miniverses) we recall that all countable infinities have same (aleph-naught) cardinality (Cantor). Using Godel-type numbering, count PB in our miniverse by primes. This uses first N primes. Both MW and IQF models presume splitting of miniverses as springing (potentially) from each PB, making each PB infinitely rich, inexhaustible and unique. Next branching level is counted by integers p1Ep2, third level by p1Ep2Ep3 integers, etc, ad infinitum. To count in up and down directions from "our" miniverse, different branching subsets of powers of primes can be used at all levels of tower exponentiation. Thus, all PB in all infinitude of MW and/or IQF branches can be uniquely counted by never repeating integers (tower exponents of primes), offering escape from grim ER scenarios.

  10. Holographic Noise in Michelson Interferometers: A Direct Experimental Probe of Unification at the Planck Scale

    ScienceCinema

    Hogan, Craig

    2016-07-12

    Classical spacetime and quantum mass-energy form the basis of all of physics. They become inconsistent at the Planck scale, 5.4 times 10^{-44} seconds, which may signify a need for reconciliation in a unified theory. Although proposals for unified theories exist, a direct experimental probe of this scale, 16 orders of magnitude above Tevatron energy, has seemed hopelessly out of reach. However in a particular interpretation of holographic unified theories, derived from black hole evaporation physics, a world assembled out of Planck-scale waves displays effects of unification with a new kind of uncertainty in position at the Planck diffraction scale, the geometric mean of the Planck length and the apparatus size. In this case a new phenomenon may measurable, an indeterminacy of spacetime position that appears as noise in interferometers. The colloquium will discuss the theory of the effect, and our plans to build a holographic interferometer at Fermilab to measure it.

  11. Steady-state benchmarks of DK4D: A time-dependent, axisymmetric drift-kinetic equation solvera)

    NASA Astrophysics Data System (ADS)

    Lyons, B. C.; Jardin, S. C.; Ramos, J. J.

    2015-05-01

    The DK4D code has been written to solve a set of time-dependent, axisymmetric, finite-Larmor-radius drift-kinetic equations (DKEs) for the non-Maxwellian part of the electron and ion distribution functions using the full, linearized Fokker-Planck-Landau collision operator. The plasma is assumed to be in the low- to finite-collisionality regime, as is found in the cores of modern and future magnetic confinement fusion experiments. Each DKE is formulated such that the perturbed distribution function carries no net density, parallel momentum, or kinetic energy. Rather, these quantities are contained within the background Maxwellians and would be evolved by an appropriate set of extended magnetohydrodynamic (MHD) equations. This formulation allows for straight-forward coupling of DK4D to existing extended MHD time evolution codes. DK4D uses a mix of implicit and explicit temporal representations and finite element and spectral spatial representations. These, along with other computational methods used, are discussed extensively. Steady-state benchmarks are then presented comparing the results of DK4D to expected analytic results at low collisionality, qualitatively, and to the Sauter analytic fits for the neoclassical conductivity and bootstrap current, quantitatively. These benchmarks confirm that DK4D is capable of solving for the correct, gyroaveraged distribution function in stationary magnetic equilibria. Furthermore, the results presented demonstrate how the exact drift-kinetic solution varies with collisionality as a function of the magnetic moment and the poloidal angle.

  12. Relation between the 4d superconformal index and the S 3 partition function

    NASA Astrophysics Data System (ADS)

    Imamura, Yosuke

    2011-09-01

    A relation between the 4d superconformal index and the S 3 partition function is studied with focus on the 4d and 3d actions used in localization. In the case of vanishing Chern-Simons levels and round S 3 we explicitly show that the 3d action is obtained from the4d action by dimensional reduction up to terms which do not affect the exact results. By combining this fact and a recent proposal concerning a squashing of S 3 and SU(2) Wilson line, we obtain a formula which gives the partition function depending on the Weyl weight of chiral multiplets, real mass parameters, FI parameters, and a squashing parameter as a limit of the index of a parent 4d theory.

  13. Bounds on very low reheating scenarios after Planck

    NASA Astrophysics Data System (ADS)

    de Salas, P. F.; Lattanzi, M.; Mangano, G.; Miele, G.; Pastor, S.; Pisanti, O.

    2015-12-01

    We consider the case of very low reheating scenarios [TRH˜O (MeV ) ] with a better calculation of the production of the relic neutrino background (with three-flavor oscillations). At 95% confidence level, a lower bound on the reheating temperature TRH>4.1 MeV is obtained from big bang nucleosynthesis, while TRH>4.7 MeV from Planck data (allowing neutrino masses to vary), the most stringent bound on the reheating temperature to date. Neutrino masses as large as 1 eV are possible for very low reheating temperatures.

  14. Planck intermediate results. I. Further validation of new Planck clusters with XMM-Newton

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Aghanim, N.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Balbi, A.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Bernard, J.-P.; Bersanelli, M.; Böhringer, H.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bourdin, H.; Brown, M. L.; Burigana, C.; Butler, R. C.; Cabella, P.; Cardoso, J.-F.; Carvalho, P.; Catalano, A.; Cayón, L.; Chamballu, A.; Chary, R.-R.; Chiang, L.-Y.; Chon, G.; Christensen, P. R.; Clements, D. L.; Colafrancesco, S.; Colombi, S.; Coulais, A.; Crill, B. P.; Cuttaia, F.; Da Silva, A.; Dahle, H.; Davis, R. J.; de Bernardis, P.; de Gasperis, G.; de Zotti, G.; Delabrouille, J.; Démoclès, J.; Désert, F.-X.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Dupac, X.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Flores-Cacho, I.; Forni, O.; Fosalba, P.; Frailis, M.; Fromenteau, S.; Galeotta, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; González-Nuevo, J.; González-Riestra, R.; Górski, K. M.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Harrison, D.; Hempel, A.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hornstrup, A.; Huffenberger, K. M.; Hurier, G.; Jagemann, T.; Jasche, J.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lawrence, C. R.; Leach, S.; Leonardi, R.; Liddle, A.; Lilje, P. B.; López-Caniego, M.; Luzzi, G.; Macías-Pérez, J. F.; Maino, D.; Mandolesi, N.; Mann, R.; Marleau, F.; Marshall, D. J.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Naselsky, P.; Natoli, P.; Nørgaard-Nielsen, H. U.; Noviello, F.; Osborne, S.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perrotta, F.; Piacentini, F.; Pierpaoli, E.; Plaszczynski, S.; Platania, P.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Savini, G.; Schaefer, B. M.; Scott, D.; Smoot, G. F.; Starck, J.-L.; Stivoli, F.; Sunyaev, R.; Sutton, D.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Valenziano, L.; Van Tent, B.; Vielva, P.; Villa, F.; Vittorio, N.; Wandelt, B. D.; Weller, J.; White, S. D. M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2012-07-01

    We present further results from the ongoing XMM-Newton validation follow-up of Planck cluster candidates, detailing X-ray observations of eleven candidates detected at a signal-to-noise ratio of 4.5 < S/N < 5.3 in the same 10-month survey maps used in the construction of the Early SZ sample. The sample was selected in order to test internal SZ quality flags, and the pertinence of these flags is discussed in light of the validation results. Ten of the candidates are found to be bona fide clusters lying below the RASS flux limit. Redshift estimates are available for all confirmed systems via X-ray Fe-line spectroscopy. They lie in the redshift range 0.19 < z < 0.94, demonstrating Planck’s capability to detect clusters up to high z. The X-ray properties of the new clusters appear to be similar to previous new detections by Planck at lower z and higher SZ flux: the majority are X-ray underluminous for their mass, estimated using YX as mass proxy, and many have a disturbed morphology. We find tentative indication for Malmquist bias in the YSZ-YX relation, with a turnover at YSZ ~ 4 × 10-4 arcmin2. We present additional new optical redshift determinations with ENO and ESO telescopes of candidates previously confirmed with XMM-Newton. The X-ray and optical redshifts for a total of 20 clusters are found to be in excellent agreement. We also show that useful lower limits can be put on cluster redshifts using X-ray data only via the use of the YX vs. YSZ and X-ray flux FX vs. YSZ relations.

  15. Development of an immunoassay for determination of 2,4-dichlorophenoxyacetic acid (2,4-D) based upon the recombinant Fab fragment of 2,4-D specific antibody

    NASA Astrophysics Data System (ADS)

    Nguyen, Van C.; Nguyen, Thi D. T.; Dau, Hung A.; Tham, Thu N.; Quyen, Dinh T.; Bachmman, Till; Schmid, Rolf D.

    2001-09-01

    To develop an immunoassay and further an immunosensor for 2,4-D based upon recombinant antibody, the Fab fragments of 2,4-D specific antibody were expressed in E. coli. Western blotting analysis of the periplasmic cell fractions shown that under the non-reducing condition only a single protein band at a molecular mass of 45-kDa, corresponding to the whole Fab fragment was detected. Antigen binding activity for 2,4-D was found only in the extract of cells bearing the 2,4-D plasmid. An immunoassay based on the competitive reaction of 2,4-D and enzyme tracer with 2,4-D Fab fragments immobilized on micro titer plates via rabbit anti-mouse IgC was developed. Using this assay, 2,4-D could be detected at concentration range of 0.5 (mu) g/1 to 10(mu) g/1. The center point of the 2,4-D test was found at a concentration of 5 (mu) g/l. The assay was applied for detection of 2,4-D in spiked orange samples, resulting in recovery rate of 90 percent. The immunoassay could be applied to monitor human exposure to 2,4-D from contamination in fruit samples.

  16. 4D electron microscopy: principles and applications.

    PubMed

    Flannigan, David J; Zewail, Ahmed H

    2012-10-16

    achievable with short intense pulses containing a large number of electrons, however, are limited to tens of nanometers and nanoseconds, respectively. This is because Coulomb repulsion is significant in such a pulse, and the electrons spread in space and time, thus limiting the beam coherence. It is therefore not possible to image the ultrafast elementary dynamics of complex transformations. The challenge was to retain the high spatial resolution of a conventional TEM while simultaneously enabling the temporal resolution required to visualize atomic-scale motions. In this Account, we discuss the development of four-dimensional ultrafast electron microscopy (4D UEM) and summarize techniques and applications that illustrate the power of the approach. In UEM, images are obtained either stroboscopically with coherent single-electron packets or with a single electron bunch. Coulomb repulsion is absent under the single-electron condition, thus permitting imaging, diffraction, and spectroscopy, all with high spatiotemporal resolution, the atomic scale (sub-nanometer and femtosecond). The time resolution is limited only by the laser pulse duration and energy carried by the electron packets; the CCD camera has no bearing on the temporal resolution. In the regime of single pulses of electrons, the temporal resolution of picoseconds can be attained when hundreds of electrons are in the bunch. The applications given here are selected to highlight phenomena of different length and time scales, from atomic motions during structural dynamics to phase transitions and nanomechanical oscillations. We conclude with a brief discussion of emerging methods, which include scanning ultrafast electron microscopy (S-UEM), scanning transmission ultrafast electron microscopy (ST-UEM) with convergent beams, and time-resolved imaging of biological structures at ambient conditions with environmental cells.

  17. Motion4D-library extended

    NASA Astrophysics Data System (ADS)

    Müller, Thomas

    2011-06-01

    The new version of the Motion4D-library now also includes the integration of a Sachs basis and the Jacobi equation to determine gravitational lensing of pointlike sources for arbitrary spacetimes.New version program summaryProgram title: Motion4D-libraryCatalogue identifier: AEEX_v3_0Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEEX_v3_0.htmlProgram obtainable from: CPC Program Library, Queen's University, Belfast, N. IrelandLicensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.htmlNo. of lines in distributed program, including test data, etc.: 219 441No. of bytes in distributed program, including test data, etc.: 6 968 223Distribution format: tar.gzProgramming language: C++Computer: All platforms with a C++ compilerOperating system: Linux, WindowsRAM: 61 MbytesClassification: 1.5External routines: Gnu Scientic Library (GSL) (http://www.gnu.org/software/gsl/)Catalogue identifier of previous version: AEEX_v2_0Journal reference of previous version: Comput. Phys. Comm. 181 (2010) 703Does the new version supersede the previous version?: YesNature of problem: Solve geodesic equation, parallel and Fermi-Walker transport in four-dimensional Lorentzian spacetimes. Determine gravitational lensing by integration of Jacobi equation and parallel transport of Sachs basis.Solution method: Integration of ordinary differential equations.Reasons for new version: The main novelty of the current version is the extension to integrate the Jacobi equation and the parallel transport of the Sachs basis along null geodesics. In combination, the change of the cross section of a light bundle and thus the gravitational lensing effect of a spacetime can be determined. Furthermore, we have implemented several new metrics.Summary of revisions: The main novelty of the current version is the integration of the Jacobi equation and the parallel transport of the Sachs basis along null geodesics. The corresponding set of equations readd2xμdλ2=-Γρ

  18. VizieR Online Data Catalog: Optical ident. and redshifts of Planck SZ sources (Planck+, 2016)

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Barrena, R.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoit-Levy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bikmaev, I.; Boehringer, H.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Burenin, R.; Burigana, C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Chamballu, A.; Chary, R.-R.; Chiang, H. C.; Chon, G.; Christensen, P. R.; Clements, D. L.; Colombo, L. P. L.; Combet, C.; Comis, B.; Crill, B. P.; Curto, A.; Cuttaia, F.; Dahle, H.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; De Rosa, A.; de Zotti, G.; Delabrouille, J.; Diego, J. M.; Dole, H.; Donzelli, S.; Dore, O.; Douspis, M.; Dupac, X.; Efstathiou, G.; Elsner, F.; Ensslin, T. A.; Eriksen, H. K.; Ferragamo, A.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Fromenteau, S.; Galeotta, S.; Galli, S.; Ganga, K.; Genova-Santos, R. T.; Giard, M.; Gjerlow, E.; Gonzalez-Nuevo, J.; Gorski, K. M.; Gruppuso, A.; Hansen, F. K.; Harrison, D. L.; Hempel, A.; Hernandez-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, T. R.; Keihaenen, E.; Keskitalo, R.; Khamitov, I.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Leon-Tavares, J.; Levrier, F.; Lietzen, H.; Liguori, M.; Lilje, P. B.; Linden-Vornle, M.; Lopez-Caniego, M.; Lubin, P. M.; Macias-Perez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Martin, P. G.; Martinez-Gonzalez, E.; Masi, S.; Matarrese, S.; McGehee, P.; Melchiorri, A.; Mennella, A.; Migliaccio, M.; Miville-Deschenes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Perdereau, O.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prunet, S.; Puget, J.-L.; Rachen J. P.; Rebol, O. R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubino-Martin, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Stolyarov, V.; Streblyanska, A.; Sudiwala, R.; Sunyaev, R.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tramonte, D.; Tristram, M.; Tucci, M.; Valenziano, L.; Valiviita, J.; van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-04-01

    This article is a companion paper to the Planck catalogue of SZ sources (PSZ1) published in Planck Collaboration XXIX (2014, Cat. J/A+A/581/A14). It contains the results of approximately three years of observations with telescopes at the Canary Islands observatories (IAC80, NOT, INT, TNG, WHT, and GTC), as part of the general optical follow-up programme undertaken by the Planck Collaboration. (2 data files).

  19. Planck 2015 constraints on neutrino physics

    NASA Astrophysics Data System (ADS)

    Lattanzi, Massimiliano

    2016-05-01

    Anisotropies of the cosmic microwave background radiation represent a powerful probe of neutrino physics, complementary to laboratory experiments. Here I review constraints on neutrino properties from the recent 2015 data from the Planck satellite.

  20. Planck scale unification and dynamical symmetry breaking

    SciTech Connect

    Lykken, Joseph D.; Willenbrock, Scott

    1993-09-01

    We explore the possibility of unification of gauge couplings near the Planck scale in models of extended technicolor. We observe that models of the form G X SU(3)_c X SU(2)_L X U(1)_Y cannot be realized, due to the presence of massless neutral Goldstone bosons (axions) and light charged pseudo-Goldstone bosons; thus, unification of the known forces near the Planck scale cannot be achieved. The next simplest possibility, G X SU(4)_{PS} X SU(2)_L X U(1)_{T_{3R}}, cannot lead to unification of the Pati-Salam and weak gauge groups near the Planck scale. However, superstring theory provides relations between couplings at the Planck scale without the need for an underlying grand-unified gauge group, which allows unification of the SU(4)PS and SU(2)L couplings.

  1. HEALPix in Planck and beyond

    NASA Astrophysics Data System (ADS)

    Hivon, Eric; Reinecke, Martin; Gorski, Krzysztof M.

    2015-08-01

    The Hierarchical Equal Area iso-Latitude Pixelation of the Sphere (HEALPix, http://healpix.sf.net) is both a mathematical pixelation of the sphere and a suite of software tools implementing it in many different languages (C, C++, Fortran, IDL/GDL, Java, Python). It has been used in the simulation, observation and analysis of WMAP, Planck and many other CMB and astronomical missions and has become a standard tool used in many different astronomical fields, such as large galaxy surveys (eg, SDSS), 3D structure of the Galaxy (eg, GAIA), high energy cosmic rays (eg, Pierre Auger Observatory), ..., and is fully supported by many Virtual Observatory visualization tools (eg, Aladin).Third party developments have implemented new functionalities like wavelet analysis, Minkowski functionals, structures identification, and propose wrappings or translations of HEALPix functionalities in other languages (eg, Matlab/Octave, Yorick).This talk will review what is currently possible with HEALPix, in terms of simulations, Spherical Harmonics transforms, data processing, visualization, statistical analyses, search of local extrema, pixel queries, I/O, and the projected developments including database storage and queries, multi-resolution dataset (MOC),

  2. The 4D-TECS integration for NASA TSRV airplane

    NASA Technical Reports Server (NTRS)

    Kaminer, I.; Oshaughnessy, P. R.

    1989-01-01

    The integration of the Total Energy Control System (TECS) concept with 4D navigation is described. This integration was made to increase the operational capacity of modern aircraft and encourage incorporation of this increased capability with the evolving National Airspace System (NAS). Described herein is: 4D smoothing, the basic concepts of TECS, the spoiler integration concept, an algorithm for nulling out time error, speed and altitude profile modes, manual spoiler implementation, 4D logic, and the results of linear and nonlinear analysis.

  3. Killing Weeds with 2,4-D. Extension Bulletin 389.

    ERIC Educational Resources Information Center

    Lee, Oliver C.

    Discussed is the use of the herbicide 2,4-D. Though written for farmers and agricultural workers, the pamphlet considers turf weed control and use of 2,4-D near ornamental plants. Aspects of the use of this herbicide covered are: (1) the common forms of 2,4-D; (2) plant responses and tolerances to the herbicide; (3) dilution and concentration of…

  4. The Planck Catalogue of Galactic Cold Clumps : Looking at the early stages of star-formation

    NASA Astrophysics Data System (ADS)

    Montier, Ludovic

    2015-08-01

    The Planck satellite has provided an unprecedented view of the submm sky, allowing us to search for the dust emission of Galactic cold sources. Combining Planck-HFI all-sky maps in the high frequency channels with the IRAS map at 100um, we built the Planck catalogue of Galactic Cold Clumps (PGCC, Planck 2015 results XXVIII 2015), counting 13188 sources distributed over the whole sky, and following mainly the Galactic structures at low and intermediate latitudes. This is the first all-sky catalogue of Galactic cold sources obtained with a single instrument at this resolution and sensitivity, which opens a new window on star-formation processes in our Galaxy.I will briefly describe the colour detection method used to extract the Galactic cold sources, i.e., the Cold Core Colour Detection Tool (CoCoCoDeT, Montier et al. 2010), and its application to the Planck data. I will discuss the statistical distribution of the properties of the PGCC sources (in terms of dust temperature, distance, mass, density and luminosity), which illustrates that the PGCC catalogue spans a large variety of environments and objects, from molecular clouds to cold cores, and covers various stages of evolution. The Planck catalogue is a very powerful tool to study the formation and the evolution of prestellar objects and star-forming regions.I will finally present an overview of the Herschel Key Program Galactic Cold Cores (PI. M.Juvela), which allowed us to follow-up about 350 Planck Galactic Cold Clumps, in various stages of evolution and environments. With this program, the nature and the composition of the 5' Planck sources have been revealed at a sub-arcmin resolution, showing very different configurations, such as starless cold cores or multiple Young Stellar objects still embedded in their cold envelope.

  5. Planck Telescope: optical design and verification

    NASA Astrophysics Data System (ADS)

    Martin, Philippe; Riti, Jean-Bernard; de Chambure, Daniel

    2004-06-01

    The cornerstone mission of the European Space Agency (ESA) scientific program Herschel/Planck is currently in the design manufacturing phase (phase C/D). The Planck satellite will be launched in 2007, together with Herschel. Located around the L2 Lagrange point, Planck aims at obtaining very accurate images of the Cosmic Wave Background fluctuations. Working up to high frequency (857 GHz, i.e. 350 μm wavelength), Planck is expected to give sharper images than the recently launched WMAP satellite. The Planck Telescope is an off-axis (unobscured) Gregorian antenna, with a 1.5 m diameter pupil, a small F-number (~1) and a large FOV (+/-5° circular), owing to place a large number of detectors (bolometers) in the focal plane. This paper presents the optical design, performance, and verification concept of the Planck telescope. The custom made sequential Hartmann system is described. Working at 10.6 μm, it will directly measure the wavefront of the telescope in cryogenic environment i.e. at operational conditions. This will be a major milestone in the spacecraft development.

  6. Pros and cons for C4d as a biomarker.

    PubMed

    Cohen, Danielle; Colvin, Robert B; Daha, Mohamed R; Drachenberg, Cinthia B; Haas, Mark; Nickeleit, Volker; Salmon, Jane E; Sis, Banu; Zhao, Ming-Hui; Bruijn, Jan A; Bajema, Ingeborg M

    2012-04-01

    The introduction of C4d in daily clinical practice in the late nineties aroused an ever-increasing interest in the role of antibody-mediated mechanisms in allograft rejection. As a marker of classical complement activation, C4d made it possible to visualize the direct link between anti-donor antibodies and tissue injury at sites of antibody binding in a graft. With the expanding use of C4d worldwide several limitations of C4d were identified. For instance, in ABO-incompatible transplantations C4d is present in the majority of grafts but this seems to point at 'graft accommodation' rather than antibody-mediated rejection. C4d is now increasingly recognized as a potential biomarker in other fields where antibodies can cause tissue damage, such as systemic autoimmune diseases and pregnancy. In all these fields, C4d holds promise to detect patients at risk for the consequences of antibody-mediated disease. Moreover, the emergence of new therapeutics that block complement activation makes C4d a marker with potential to identify patients who may possibly benefit from these drugs. This review provides an overview of the past, present, and future perspectives of C4d as a biomarker, focusing on its use in solid organ transplantation and discussing its possible new roles in autoimmunity and pregnancy. PMID:22297669

  7. 4D GPR Experiments--Towards the Virtual Lysimeter

    NASA Astrophysics Data System (ADS)

    Grasmueck, M.; Viggiano, D. A.; Day-Lewis, F. D.; Drasdis, J. B.; Kruse, S. E.; Or, D.

    2006-05-01

    data shows the shape and size of the imaged wet-bulb closely match the modeling and excavation results. Wetting front propagation was on the order of 0.2-0.5 m/hr. GPR detected retained water 17 hr after completion of the infiltration. In addition to pattern detection, attempts for establishing mass balance are underway. In summary, preliminary results from controlled field experiments show the 4D GPR method has the precision, resolution, and repeatability required for non-invasive detection of water-flow patterns and dynamics in the vadose zone, hence could potentially serve as a virtual lysimeter.

  8. Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential

    PubMed Central

    Powers, Ginny L.; Hammer, Kimberly D.P.; Domenech, Maribella; Frantskevich, Katsiaryna; Malinowski, Rita L.; Bushman, Wade; Beebe, David J.; Marker, Paul C.

    2014-01-01

    Phosphodiesterase 4D (PDE4D) has recently been implicated as a proliferation-promoting factor in prostate cancer and is over-expressed in human prostate carcinoma. However, the effects of PDE4D inhibition using pharmacological inhibitors have not been examined in prostate cancer. These studies examined the effects of selective PDE4D inhibitors, NVP-ABE171 and cilomilast, as anti-prostate cancer therapies in both in vitro and in vivo models. The effects of PDE4D inhibitors on pathways that are critical in prostate cancer and/or downstream of cyclic AMP (cAMP) were examined. Both NVP-ABE171 and cilomilast decreased cell growth. In vitro, PDE4D inhibitors lead to decreased signaling of the sonic hedgehog (SHH), Androgen Receptor (AR), and MAPK pathways, but growth inhibition was best correlated to the sonic hedgehog pathway. PDE4D inhibition also reduced proliferation of epithelial cells induced by paracrine signaling from co-cultured stromal cells that had activated hedgehog signaling. In addition, PDE4D inhibitors decreased the weight of the prostate in wild-type mice. Prostate cancer xenografts grown in nude mice that were treated with cilomilast or NVP-ABE171 had decreased wet weight and increased apoptosis compared to vehicle treated controls. These studies suggest the pharmacological inhibition of PDE4D using small molecule inhibitors is an effective option for prostate cancer therapy. Implications PDE4D inhibitors decrease the growth of prostate cancer cells in vivo and in vitro, and PDE4D inhibition has therapeutic potential in prostate cancer. PMID:25149359

  9. 4D Printing with Mechanically Robust, Thermally Actuating Hydrogels.

    PubMed

    Bakarich, Shannon E; Gorkin, Robert; in het Panhuis, Marc; Spinks, Geoffrey M

    2015-06-01

    A smart valve is created by 4D printing of hydrogels that are both mechanically robust and thermally actuating. The printed hydrogels are made up of an interpenetrating network of alginate and poly(N-isopropylacrylamide). 4D structures are created by printing the "dynamic" hydrogel ink alongside other static materials. PMID:25864515

  10. 32 CFR 1645.4 - Exclusion from Class 4-D.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MINISTERS OF RELIGION § 1645.4 Exclusion from Class 4-D. A registrant is excluded from Class 4-D when his... duly ordained minister of religion in accordance with the ceremonial rite or discipline of a church... principles of religion and administer the ordinances of public worship, as embodied in the creed...

  11. 4D Printing with Mechanically Robust, Thermally Actuating Hydrogels.

    PubMed

    Bakarich, Shannon E; Gorkin, Robert; in het Panhuis, Marc; Spinks, Geoffrey M

    2015-06-01

    A smart valve is created by 4D printing of hydrogels that are both mechanically robust and thermally actuating. The printed hydrogels are made up of an interpenetrating network of alginate and poly(N-isopropylacrylamide). 4D structures are created by printing the "dynamic" hydrogel ink alongside other static materials.

  12. 32 CFR 1645.4 - Exclusion from Class 4-D.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... MINISTERS OF RELIGION § 1645.4 Exclusion from Class 4-D. A registrant is excluded from Class 4-D when his... duly ordained minister of religion in accordance with the ceremonial rite or discipline of a church... principles of religion and administer the ordinances of public worship, as embodied in the creed...

  13. 32 CFR 1645.4 - Exclusion from Class 4-D.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... MINISTERS OF RELIGION § 1645.4 Exclusion from Class 4-D. A registrant is excluded from Class 4-D when his... duly ordained minister of religion in accordance with the ceremonial rite or discipline of a church... principles of religion and administer the ordinances of public worship, as embodied in the creed...

  14. 32 CFR 1645.4 - Exclusion from Class 4-D.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... MINISTERS OF RELIGION § 1645.4 Exclusion from Class 4-D. A registrant is excluded from Class 4-D when his... duly ordained minister of religion in accordance with the ceremonial rite or discipline of a church... principles of religion and administer the ordinances of public worship, as embodied in the creed...

  15. 32 CFR 1645.4 - Exclusion from Class 4-D.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... MINISTERS OF RELIGION § 1645.4 Exclusion from Class 4-D. A registrant is excluded from Class 4-D when his... duly ordained minister of religion in accordance with the ceremonial rite or discipline of a church... principles of religion and administer the ordinances of public worship, as embodied in the creed...

  16. Composite inflation confronts BICEP2 and PLANCK

    NASA Astrophysics Data System (ADS)

    Karwan, Khamphee; Channuie, Phongpichit

    2014-06-01

    We examine observational constraints on single-field inflation in which the inflaton is a composite field stemming from a four-dimensional strongly interacting field theory. We confront the predictions with the Planck and very recent BICEP2 data. In the large non-minimal coupling regions, we discover for the minimal composite inflationary model that the predictions lie well inside the joint 68% CL for the Planck data, but is in tension with the recent BICEP2 observations. In the case of the glueball inflationary model, the predictions satisfy the Planck results. However, this model can produce a large tensor-to-scalar ratio consistent with the recent BICEP2 observations if the number of e-foldings is slightly smaller than the range commonly used. For a super Yang-Mills paradigm, we discover that the predictions satisfy the Planck data, and surprisingly a large tensor-to-scalar ratio consistent with the BICEP2 results can also be produced for an acceptable range of the number of e-foldings and of the confining scale. In the small non-minimal coupling regions, all of the models can satisfy the BICEP2 results. However, the predictions of the glueball and superglueball inflationary models cannot satisfy the observational bound on the amplitude of the curvature perturbation launched by Planck, and the techni-inflaton self-coupling in the minimal composite inflationary model is constrained to be extremely small.

  17. 4D-fingerprints, universal QSAR and QSPR descriptors.

    PubMed

    Senese, Craig L; Duca, J; Pan, D; Hopfinger, A J; Tseng, Y J

    2004-01-01

    An elusive goal in the field of chemoinformatics and molecular modeling has been the generation of a set of descriptors that, once calculated for a molecule, may be used in a wide variety of applications. Since such universal descriptors are generated free from external constraints, they are inherently independent of the data set in which they are employed. The realization of a set of universal descriptors would significantly streamline such chemoinformatics tasks as virtual high-throughout screening (VHTS) and toxicity profiling. The current study reports the derivation and validation of a potential set of universal descriptors, referred to as the 4D-fingerprints. The 4D-fingerprints are derived from the 4D-molecular similarity analysis. To evaluate the applicability of the 4D-fingerprints as universal descriptors, they are used to generate descriptive QSAR models for 5 independent training sets. Each of the training sets has been analyzed previously by several varying QSAR methods, and the results of the models generated using the 4D-fingerprints are compared to the results of the previous QSAR analyses. It was found that the models generated using the 4D-fingerprints are comparable in quality, based on statistical measures of fit and test set prediction, to the previously reported models for the other QSAR methods. This finding is particularly significant considering the 4D-fingerprints are generated independent of external constraints such as alignment, while the QSAR methods used for comparison all require an alignment analysis.

  18. Planck, the Quantum, and the Historians

    NASA Astrophysics Data System (ADS)

    Gearhart, Clayton A.

    2002-05-01

    In late 1900, the German theoretical physicist Max Planck derived an expression for the spectrum of black-body radiation. That derivation was the first step in the introduction of quantum concepts into physics. But how did Planck think about his result in the early years of the twentieth century? Did he assume that his derivation was consistent with the continuous energies inherent in Maxwellian electrodynamics and Newtonian mechanics? Or did he see the beginnings, however tentative and uncertain, of the quantum revolution to come? Historians of physics have debated this question for over twenty years. In this article, I review that debate and, at the same time, present Planck's achievement in its historical context.

  19. Planck Scale Gravity Test with Accelerators

    NASA Astrophysics Data System (ADS)

    Gharibyan, V.

    2015-01-01

    Quantum or torsion gravity models predict unusual properties of space-time at very short distances. In particular, near the Planck length, around 10-35m, empty space may behave as a crystal, singly or doubly refractive. However, this hypothesis remains uncheckable for any direct measurement since the smallest distance accessible in experiment is about 10-19m at the LHC. Here I propose a laboratory test to measure the space refractivity and birefringence induced by gravity. A sensitivity from 10-31m down to the Planck length could be reached at existent GeV and future TeV energy lepton accelerators using laser Compton scattering. There are already experimental hints for gravity signature at distances approaching the Planck length by 5-7 orders of magnitude, derived from SLC and HERA data.

  20. Testing Planck-scale gravity with accelerators.

    PubMed

    Gharibyan, Vahagn

    2012-10-01

    Quantum or torsion gravity models predict unusual properties of space-time at very short distances. In particular, near the Planck length, around 10(-35)  m, empty space may behave as a crystal, singly or doubly refractive. However, this hypothesis remains uncheckable for any direct measurement, since the smallest distance accessible in experiment is about 10(-19)  m at the LHC. Here I propose a laboratory test to measure the space refractivity and birefringence induced by gravity. A sensitivity from 10(-31)  m down to the Planck length could be reached at existent GeV and future TeV energy lepton accelerators using laser Compton scattering. There are already experimental hints for gravity signature at distances approaching the Planck length by 5-7 orders of magnitude, derived from SLC and HERA data.

  1. Watt balance experiments for the determination of the Planck constant and the redefinition of the kilogram

    NASA Astrophysics Data System (ADS)

    Stock, M.

    2013-02-01

    Since 1889 the international prototype of the kilogram has served as the definition of the unit of mass in the International System of Units (SI). It is the last material artefact to define a base unit of the SI, and it influences several other base units. This situation is no longer acceptable in a time of ever increasing measurement precision. It is therefore planned to redefine the unit of mass by fixing the numerical value of the Planck constant. At the same time three other base units, the ampere, the kelvin and the mole, will be redefined. As a first step, the kilogram redefinition requires a highly accurate determination of the Planck constant in the present SI system, with a relative uncertainty of the order of 1 part in 108. The most promising experiment for this purpose, and for the future realization of the kilogram, is the watt balance. It compares mechanical and electrical power and makes use of two macroscopic quantum effects, thus creating a relationship between a macroscopic mass and the Planck constant. In this paper the background for the choice of the Planck constant for the kilogram redefinition is discussed and the role of the Planck constant in physics is briefly reviewed. The operating principle of watt balance experiments is explained and the existing experiments are reviewed. An overview is given of all presently available experimental determinations of the Planck constant, and it is shown that further investigation is needed before the redefinition of the kilogram can take place. This article is based on a lecture given at the International School of Physics ‘Enrico Fermi’, Course CLXXXV: Metrology and Physical Constants, held in Varenna on 17-27 July 2012. It will also be published in the proceedings of the school, edited by E Bava, M Kühne and A M Rossi (IOS Press, Amsterdam and SIF, Bologna).

  2. C4d staining as immunohistochemical marker in inflammatory myopathies.

    PubMed

    Pytel, Peter

    2014-10-01

    The diagnosis of an inflammatory myopathy is often established based on basic histologic studies. Additional immunohistochemical studies are sometimes required to support the diagnosis and the classification of inflammatory myopathies. Staining for major histocompatibility complex 1 (MHC1) often shows increased sarcolemmal labeling in inflammatory myopathies. Endomysial capillary staining C5b-9 (membrane attack complex) is a feature that is reported as frequently associated with dermatomyositis. Immunohistochemical staining for C4d is widely used for various applications including the assessment of antibody-mediated rejection after solid organ transplantation. In the context of dermatomyositis, C4d staining has been described in skin biopsies but not in muscle biopsies. A total of 32 muscle biopsy specimens were examined. The hematoxylin and eosin-stained slides were reviewed, and immunohistochemical studies for MHC1, C5b-9, and C4d were conducted. The staining observed for C5b-9 and C4d was compared. Overall, the staining pattern for C4d mirrored the one observed for C5b-9 in the examined muscle biopsy specimens. There was high and statistically significant (P<0.0001) correlation between the staining seen with these 2 antibodies. Both antibodies labeled the cytoplasm of degenerating necrotic myofibers. In addition, both antibodies showed distinct endomysial capillary labeling in a subset of dermatomyositis. Areas with perifascicular atrophy often exhibited the most prominent vascular labeling for C4d and C5b-9. In conclusion, C4d and C5b-9 show similar expression patterns in muscle biopsies of patients with inflammatory myopathies and both highlight the presence of vascular labeling associated with dermatomyositis. C4d antibodies are widely used and may offer an alternative for C5b-9 staining.

  3. Substitutional 4d and 5d impurities in graphene.

    PubMed

    Alonso-Lanza, Tomás; Ayuela, Andrés; Aguilera-Granja, Faustino

    2016-08-21

    We describe the structural and electronic properties of graphene doped with substitutional impurities of 4d and 5d transition metals. The adsorption energies and distances for 4d and 5d metals in graphene show similar trends for the later groups in the periodic table, which are also well-known characteristics of 3d elements. However, along earlier groups the 4d impurities in graphene show very similar adsorption energies, distances and magnetic moments to the 5d ones, which can be related to the influence of the 4d and 5d lanthanide contraction. Surprisingly, within the manganese group, the total magnetic moment of 3 μB for manganese is reduced to 1 μB for technetium and rhenium. We find that compared with 3d elements, the larger size of the 4d and 5d elements causes a high degree of hybridization with the neighbouring carbon atoms, reducing spin splitting in the d levels. It seems that the magnetic adjustment of graphene could be significantly different if 4d or 5d impurities are used instead of 3d impurities.

  4. Substitutional 4d and 5d impurities in graphene.

    PubMed

    Alonso-Lanza, Tomás; Ayuela, Andrés; Aguilera-Granja, Faustino

    2016-08-21

    We describe the structural and electronic properties of graphene doped with substitutional impurities of 4d and 5d transition metals. The adsorption energies and distances for 4d and 5d metals in graphene show similar trends for the later groups in the periodic table, which are also well-known characteristics of 3d elements. However, along earlier groups the 4d impurities in graphene show very similar adsorption energies, distances and magnetic moments to the 5d ones, which can be related to the influence of the 4d and 5d lanthanide contraction. Surprisingly, within the manganese group, the total magnetic moment of 3 μB for manganese is reduced to 1 μB for technetium and rhenium. We find that compared with 3d elements, the larger size of the 4d and 5d elements causes a high degree of hybridization with the neighbouring carbon atoms, reducing spin splitting in the d levels. It seems that the magnetic adjustment of graphene could be significantly different if 4d or 5d impurities are used instead of 3d impurities. PMID:27439363

  5. How Measuring the Planck Constant gets to an Electronic Kilogram Standard

    SciTech Connect

    Steiner, Richard

    2007-08-01

    The best measurement of the Planck constant is now derived from the watt balance method. This method measures mechanical power, in reference units of the kilogram (artifact mass standard), second (atomic clocks), and meter (lasers), in ratio to electrical power, in reference units of the volt (Josephson effect) and ohm (quantum Hall effect). Of these reference standards, only the kilogram is still an artifact standard. Thus a high precision measurement of the Planck constant is equivalent to monitoring the SI kilogram artifact, and may be used to redefine the kilogram. This talk will summarize the complexity of making a Planck constant measurement, where there are interesting aspects of basic physics that appear when the ultimate precision of the standards laboratory is applied to obtain an uncertainty of 20 parts in a billion.

  6. Planck 2015 results. XXVII. The second Planck catalogue of Sunyaev-Zeldovich sources

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Barrena, R.; Bartlett, J. G.; Bartolo, N.; Battaner, E.; Battye, R.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bikmaev, I.; Böhringer, H.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bucher, M.; Burenin, R.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Carvalho, P.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chiang, H. C.; Chon, G.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Comis, B.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Dahle, H.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Eisenhardt, P. R. M.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Falgarone, E.; Fergusson, J.; Feroz, F.; Ferragamo, A.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Grainge, K. J. B.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Hempel, A.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jin, T.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Khamitov, I.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mak, D. S. Y.; Mandolesi, N.; Mangilli, A.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; McGehee, P.; Mei, S.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nastasi, A.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Olamaie, M.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrott, Y. C.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rozo, E.; Rubiño-Martín, J. A.; Rumsey, C.; Rusholme, B.; Rykoff, E. S.; Sandri, M.; Santos, D.; Saunders, R. D. E.; Savelainen, M.; Savini, G.; Schammel, M. P.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Shimwell, T. W.; Spencer, L. D.; Stanford, S. A.; Stern, D.; Stolyarov, V.; Stompor, R.; Streblyanska, A.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tramonte, D.; Tristram, M.; Tucci, M.; Tuovinen, J.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; White, S. D. M.; Wright, E. L.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    We present the all-sky Planck catalogue of Sunyaev-Zeldovich (SZ) sources detected from the 29 month full-mission data. The catalogue (PSZ2) is the largest SZ-selected sample of galaxy clusters yet produced and the deepest systematic all-sky surveyof galaxy clusters. It contains 1653 detections, of which 1203 are confirmed clusters with identified counterparts in external data sets, and is the first SZ-selected cluster survey containing >103 confirmed clusters. We present a detailed analysis of the survey selection function in terms of its completeness and statistical reliability, placing a lower limit of 83% on the purity. Using simulations, we find that the estimates of the SZ strength parameter Y5R500are robust to pressure-profile variation and beam systematics, but accurate conversion to Y500 requires the use of prior information on the cluster extent. We describe the multi-wavelength search for counterparts in ancillary data, which makes use of radio, microwave, infra-red, optical, and X-ray data sets, and which places emphasis on the robustness of the counterpart match. We discuss the physical properties of the new sample and identify a population of low-redshift X-ray under-luminous clusters revealed by SZ selection. These objects appear in optical and SZ surveys with consistent properties for their mass, but are almost absent from ROSAT X-ray selected samples.

  7. A better presentation of Planck's radiation law

    NASA Astrophysics Data System (ADS)

    Marr, Jonathan M.; Wilkin, Francis P.

    2012-05-01

    Introductory physics and astronomy courses commonly use Wien's displacement law to explain the colors of blackbodies, including the Sun and other stars, in terms of their temperatures. We argue here that focusing on the peak of the blackbody spectrum is misleading for three reasons. First, the Planck curve is too broad for an individual spectral color to stand out. Second, the location of the peak of the Planck curve depends on the choice of the independent variable in the plot. And third, Wien's displacement law is seldom used in actual practice to find a temperature and direct fitting to the Planck function is preferable. We discuss these flaws and argue that, at the introductory level, presentation of blackbody radiation in terms of photon statistics would be more effective pedagogically. The average energy of the emitted photons would then be presented in place of Wien's displacement law, and discussion of the Stefan-Boltzmann law would include the total number of photons emitted per second. Finally, we suggest that the Planck spectrum is most appropriately plotted as a ``spectral energy density per fractional bandwidth distribution,'' using a logarithmic scale for the wavelength or frequency.

  8. The watt balance: determination of the Planck constant and redefinition of the kilogram.

    PubMed

    Stock, M

    2011-10-28

    Since 1889, the international prototype of the kilogram has served as the definition of the unit of mass in the International System of Units (SI). It is the last material artefact to define a base unit of the SI, and it influences several other base units. This situation is no longer acceptable in a time of ever-increasing measurement precision. It is therefore planned to redefine the unit of mass by fixing the numerical value of the Planck constant. At the same time three other base units, the ampere, the kelvin and the mole, will be redefined. As a first step, the kilogram redefinition requires a highly accurate determination of the Planck constant in the present SI system, with a relative uncertainty of the order of 1 part in 10(8). The most promising experiment for this purpose, and for the future realization of the kilogram, is the watt balance. It compares mechanical and electrical power and makes use of two macroscopic quantum effects, thus creating a relationship between a macroscopic mass and the Planck constant. In this paper, the operating principle of watt balance experiments is explained and the existing experiments are reviewed. An overview is given of all available experimental determinations of the Planck constant, and it is shown that further investigation is needed before the redefinition of the kilogram can take place. Independent of this requirement, a consensus has been reached on the form that future definitions of the SI base units will take.

  9. Probing neutrinos from Planck and forthcoming galaxy redshift surveys

    SciTech Connect

    Takeuchi, Yoshitaka; Kadota, Kenji E-mail: kadota.kenji@f.nagoya-u.jp

    2014-01-01

    We investigate how much the constraints on the neutrino properties can be improved by combining the CMB, the photometric and spectroscopic galaxy redshift surveys which include the CMB lensing, galaxy lensing tomography, galaxy clustering and redshift space distortion observables. We pay a particular attention to the constraint on the neutrino mass in view of the forthcoming redshift surveys such as the Euclid satellite and the LSST survey along with the Planck CMB lensing measurements. Combining the transverse mode information from the angular power spectrum and the longitudinal mode information from the spectroscopic survey with the redshift space distortion measurements can determine the total neutrino mass with the projected error of O(0.02) eV. Our analysis fixes the mass splittings among the neutrino species to be consistent with the neutrino oscillation data, and we accordingly study the sensitivity of our parameter estimations on the minimal neutrino mass. The cosmological measurement of the total neutrino mass can distinguish between the normal and inverted mass hierarchy scenarios if the minimal neutrino mass ∼<0.005 eV with the predicted 1–σ uncertainties taken into account.

  10. A dose error evaluation study for 4D dose calculations

    NASA Astrophysics Data System (ADS)

    Milz, Stefan; Wilkens, Jan J.; Ullrich, Wolfgang

    2014-10-01

    Previous studies have shown that respiration induced motion is not negligible for Stereotactic Body Radiation Therapy. The intrafractional breathing induced motion influences the delivered dose distribution on the underlying patient geometry such as the lung or the abdomen. If a static geometry is used, a planning process for these indications does not represent the entire dynamic process. The quality of a full 4D dose calculation approach depends on the dose coordinate transformation process between deformable geometries. This article provides an evaluation study that introduces an advanced method to verify the quality of numerical dose transformation generated by four different algorithms. The used transformation metric value is based on the deviation of the dose mass histogram (DMH) and the mean dose throughout dose transformation. The study compares the results of four algorithms. In general, two elementary approaches are used: dose mapping and energy transformation. Dose interpolation (DIM) and an advanced concept, so called divergent dose mapping model (dDMM), are used for dose mapping. The algorithms are compared to the basic energy transformation model (bETM) and the energy mass congruent mapping (EMCM). For evaluation 900 small sample regions of interest (ROI) are generated inside an exemplary lung geometry (4DCT). A homogeneous fluence distribution is assumed for dose calculation inside the ROIs. The dose transformations are performed with the four different algorithms. The study investigates the DMH-metric and the mean dose metric for different scenarios (voxel sizes: 8 mm, 4 mm, 2 mm, 1 mm 9 different breathing phases). dDMM achieves the best transformation accuracy in all measured test cases with 3-5% lower errors than the other models. The results of dDMM are reasonable and most efficient in this study, although the model is simple and easy to implement. The EMCM model also achieved suitable results, but the approach requires a more complex

  11. Planck satellite to be presented to media

    NASA Astrophysics Data System (ADS)

    2007-01-01

    Planck will make the most accurate maps yet of the microwave background radiation that fills space. It will be sensitive to temperature variations of a few millionths of a degree and will map the full sky in nine wavelengths. The immediate outcome of the Big Bang and the initial conditions for the evolution in the universe’s structure are the primary target of this important mission. From the results, a great deal more will be learnt not only about the nature and amount of dark matter, the ‘missing mass’ of the universe, but also about the nature of dark energy and the expansion of the universe itself. To address such challenging objectives, Planck will need to operate at very low, stable temperatures. Once in space, its detectors will have to be cooled to temperature levels close to absolute zero (-273.15ºC), ranging from -253ºC to only a few tenths of a degree above absolute zero. The Planck spacecraft thus has to be a marvel of cryotechnology. After integration, Planck will start a series of tests that will continue into early-2008. It will be launched by end-July 2008 in a dual-launch configuration with Herschel, ESA’s mission to study the formation of galaxies, stars and planetary systems in the infrared. Interested media are invited to fill in the reply form below. Note to editors The Planck spacecraft was built by AAS Cannes, the prime contractor, leading a consortium of industrial partners with the AAS industry branch in Turin, Italy, responsible for the satellite’s service module. ESA and the Danish National Space Centre (Copenhagen, Denmark) are responsible for the hardware provision of Planck’s telescope mirrors, manufactured by EADS Astrium (Friedrichshafen, Germany). AAS Cannes is also responsible for the payload module, the platform that hosts the telescope and the two onboard instruments, HFI and LFI. The instruments themselves are being supplied by a consortium of scientists and institutes led by the Institut d'Astrophysique Spatiale

  12. Induced gravity and Planck zeros

    NASA Astrophysics Data System (ADS)

    Khuri, N. N.

    1982-11-01

    Starting with an asymptotically free gauge theory with dynamical symmetry breaking and a mass hierarchy, we investigate the Adler-Zee formula for the induced gravitational constant. We study the two-point function ψ(q2), constructed with the trace of the energy-momentum tensor. First, we show that if the zeros of ψ are at a mass scale significantly below the leading scale, then Gind-1=O(mzero2) making it impossible to get a realistic Gind from the Adler-Zee formula with low-mass zeros. Next we use the Jensen formula to derive a sum rule for |mzero|. The analysis of this sum rule coupled with the result above leads to a dilemma with only one reasonable resolution. To get a realistic Gind from the Adler-Zee formula, ψ(q2) must have a pair of complex-conjugate zeros at q2=M02+/-2iγM0, where M0 is large and of the maximal scale and γM0<<1. The presence of this zero essentially determines Gind-1. It gives a lower bound, which with our previously derived general upper bound gives [π24(ln10)288]CψM02<=(16πG)-1<=[5π2288]CψM02, where Cψ is the anomaly coefficient, a number easily determined by low-order perturbation theory for any group.

  13. Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer.

    PubMed

    Yang, Ying-Hua; Buhamrah, Asma; Schneider, Abraham; Lin, Yi-Ling; Zhou, Hua; Bugshan, Amr; Basile, John R

    2016-01-01

    Bone density is controlled by interactions between osteoclasts, which resorb bone, and osteoblasts, which deposit it. The semaphorins and their receptors, the plexins, originally shown to function in the immune system and to provide chemotactic cues for axon guidance, are now known to play a role in this process as well. Emerging data have identified Semaphorin 4D (Sema4D) as a product of osteoclasts acting through its receptor Plexin-B1 on osteoblasts to inhibit their function, tipping the balance of bone homeostasis in favor of resorption. Breast cancers and other epithelial malignancies overexpress Sema4D, so we theorized that tumor cells could be exploiting this pathway to establish lytic skeletal metastases. Here, we use measurements of osteoblast and osteoclast differentiation and function in vitro and a mouse model of skeletal metastasis to demonstrate that both soluble Sema4D and protein produced by the breast cancer cell line MDA-MB-231 inhibits differentiation of MC3T3 cells, an osteoblast cell line, and their ability to form mineralized tissues, while Sema4D-mediated induction of IL-8 and LIX/CXCL5, the murine homologue of IL-8, increases osteoclast numbers and activity. We also observe a decrease in the number of bone metastases in mice injected with MDA-MB-231 cells when Sema4D is silenced by RNA interference. These results are significant because treatments directed at suppression of skeletal metastases in bone-homing malignancies usually work by arresting bone remodeling, potentially leading to skeletal fragility, a significant problem in patient management. Targeting Sema4D in these cancers would not affect bone remodeling and therefore could elicit an improved therapeutic result without the debilitating side effects.

  14. Soil matrix and macropore biodegradation of 2,4-D

    SciTech Connect

    Pivetz, B.E.; Steenhuis, T.S.

    1995-07-01

    Preferential flow of pesticides in macropores can lead to decreased travel times through the vadose zone and increased groundwater contamination. Macropores, however, may present a favorable environment for biodegradation because of greater oxygen, nutrient, and substrate supply, and higher microbial populations in earthworm burrows, compared to the soil matrix. The biodegradation of 2,4-dichlorophenoxyacetic acid (2,4-D) was measured in macropores and soil matrix of packed soil columns (7.0-cm diam., 10-cm length) and undisturbed cores contained as well-defined artificial macropore and the undisturbed cores contained earthworm-burrow macropores. A 50 {mu}g/L 2,4-D solution was continuously applied to the unsaturated soil surface and breakthrough curves (BTCs) indicating pesticide loss in the effluent were obtained from the soil matrix and macropore flow paths. Biodegradation rates were calculated separately for each flow path by comparing the BTCs to BTCs representing abiotic conditions, and dividing the 2,4-D loss by the travel time through each flow path. The biodegradation rates increased with time in both flow paths, and the final biodegradation rate in the macropore region surpassed that of the matrix, presumably because of increased microbial populations in the macropore. Complete loss of the 2,4-D in both flow paths was observed after continuous application of 2,4-D for 400 h, with maximum column-averaged 2,4-D loss rates of 0.879 {mu}g/(L h) in the matrix and 1.073 {mu}g/(L h) in the macropore. Biodegradation of 2,4-D was also observed in the macropore and matrix regions of the undisturbed soil cores. 19 refs., 7 figs., 2 tabs.

  15. Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer

    PubMed Central

    Yang, Ying-Hua; Buhamrah, Asma; Schneider, Abraham; Lin, Yi-Ling; Zhou, Hua; Bugshan, Amr; Basile, John R.

    2016-01-01

    Bone density is controlled by interactions between osteoclasts, which resorb bone, and osteoblasts, which deposit it. The semaphorins and their receptors, the plexins, originally shown to function in the immune system and to provide chemotactic cues for axon guidance, are now known to play a role in this process as well. Emerging data have identified Semaphorin 4D (Sema4D) as a product of osteoclasts acting through its receptor Plexin-B1 on osteoblasts to inhibit their function, tipping the balance of bone homeostasis in favor of resorption. Breast cancers and other epithelial malignancies overexpress Sema4D, so we theorized that tumor cells could be exploiting this pathway to establish lytic skeletal metastases. Here, we use measurements of osteoblast and osteoclast differentiation and function in vitro and a mouse model of skeletal metastasis to demonstrate that both soluble Sema4D and protein produced by the breast cancer cell line MDA-MB-231 inhibits differentiation of MC3T3 cells, an osteoblast cell line, and their ability to form mineralized tissues, while Sema4D-mediated induction of IL-8 and LIX/CXCL5, the murine homologue of IL-8, increases osteoclast numbers and activity. We also observe a decrease in the number of bone metastases in mice injected with MDA-MB-231 cells when Sema4D is silenced by RNA interference. These results are significant because treatments directed at suppression of skeletal metastases in bone-homing malignancies usually work by arresting bone remodeling, potentially leading to skeletal fragility, a significant problem in patient management. Targeting Sema4D in these cancers would not affect bone remodeling and therefore could elicit an improved therapeutic result without the debilitating side effects. PMID:26910109

  16. Planck 2015 results. XV. Gravitational lensing

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Lewis, A.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; White, M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    We present the most significant measurement of the cosmic microwave background (CMB) lensing potential to date (at a level of 40σ), using temperature and polarization data from the Planck 2015 full-mission release. Using a polarization-only estimator, we detect lensing at a significance of 5σ. We cross-check the accuracy of our measurement using the wide frequency coverage and complementarity of the temperature and polarization measurements. Public products based on this measurement include an estimate of the lensing potential over approximately 70% of the sky, an estimate of the lensing potential power spectrum in bandpowers for the multipole range 40 ≤ L ≤ 400, and an associated likelihood for cosmological parameter constraints. We find good agreement between our measurement of the lensing potential power spectrum and that found in the ΛCDM model that best fits the Planck temperature and polarization power spectra. Using the lensing likelihood alone we obtain a percent-level measurement of the parameter combination σ8Ω0.25m = 0.591 ± 0.021. We combine our determination of the lensing potential with the E-mode polarization, also measured by Planck, to generate an estimate of the lensing B-mode. We show that this lensing B-mode estimate is correlated with the B-modes observed directly by Planck at the expected level and with a statistical significance of 10σ, confirming Planck's sensitivity to this known sky signal. We also correlate our lensing potential estimate with the large-scale temperature anisotropies, detecting a cross-correlation at the 3σ level, as expected because of dark energy in the concordance ΛCDM model.

  17. Motion artifacts occurring at the lung/diaphragm interface using 4D CT attenuation correction of 4D PET scans.

    PubMed

    Killoran, Joseph H; Gerbaudo, Victor H; Mamede, Marcelo; Ionascu, Dan; Park, Sang-June; Berbeco, Ross

    2011-11-15

    For PET/CT, fast CT acquisition time can lead to errors in attenuation correction, particularly at the lung/diaphragm interface. Gated 4D PET can reduce motion artifacts, though residual artifacts may persist depending on the CT dataset used for attenuation correction. We performed phantom studies to evaluate 4D PET images of targets near a density interface using three different methods for attenuation correction: a single 3D CT (3D CTAC), an averaged 4D CT (CINE CTAC), and a fully phase matched 4D CT (4D CTAC). A phantom was designed with two density regions corresponding to diaphragm and lung. An 8 mL sphere phantom loaded with 18F-FDG was used to represent a lung tumor and background FDG included at an 8:1 ratio. Motion patterns of sin(x) and sin4(x) were used for dynamic studies. Image data was acquired using a GE Discovery DVCT-PET/CT scanner. Attenuation correction methods were compared based on normalized recovery coefficient (NRC), as well as a novel quantity "fixed activity volume" (FAV) introduced in our report. Image metrics were compared to those determined from a 3D PET scan with no motion present (3D STATIC). Values of FAV and NRC showed significant variation over the motion cycle when corrected by 3D CTAC images. 4D CTAC- and CINE CTAC-corrected PET images reduced these motion artifacts. The amount of artifact reduction is greater when the target is surrounded by lower density material and when motion was based on sin4(x). 4D CTAC reduced artifacts more than CINE CTAC for most scenarios. For a target surrounded by water equivalent material, there was no advantage to 4D CTAC over CINE CTAC when using the sin(x) motion pattern. Attenuation correction using both 4D CTAC or CINE CTAC can reduce motion artifacts in regions that include a tissue interface such as the lung/diaphragm border. 4D CTAC is more effective than CINE CTAC at reducing artifacts in some, but not all, scenarios.

  18. 4-D reconstruction for dynamic fluorescence diffuse optical tomography.

    PubMed

    Liu, Xin; Zhang, Bin; Luo, Jianwen; Bai, Jing

    2012-11-01

    Dynamic fluorescence diffuse optical tomography (FDOT) is important for the research of drug delivery, medical diagnosis and treatment. Conventionally, dynamic tomographic images are reconstructed frame by frame, independently. This approach fails to account for the temporal correlations in measurement data. Ideally, the entire image sequence should be considered as a whole and a four-dimensional (4-D) reconstruction should be performed. However, the fully 4-D reconstruction is computationally intensive. In this paper, we propose a new 4-D reconstruction approach for dynamic FDOT, which is achieved by applying a temporal Karhunen-Loève (KL) transformation to the imaging equation. By taking advantage of the decorrelation and compression properties of the KL transformation, the complex 4-D optical reconstruction problem is greatly simplified. To evaluate the performance of the method, simulation, phantom, and in vivo experiments (N=7) are performed on a hybrid FDOT/x-ray computed tomography imaging system. The experimental results indicate that the reconstruction images obtained by the KL method provide good reconstruction quality. Additionally, by discarding high-order KL components, the computation time involved with fully 4-D reconstruction can be greatly reduced in contrast to the conventional frame-by-frame reconstruction.

  19. New C4D Sensor with a Simulated Inductor

    PubMed Central

    Lyu, Yingchao; Ji, Haifeng; Yang, Shijie; Huang, Zhiyao; Wang, Baoliang; Li, Haiqing

    2016-01-01

    A new capacitively coupled contactless conductivity detection (C4D) sensor with an improved simulated inductor is developed in this work. The improved simulated inductor is designed on the basis of the Riordan-type floating simulated inductor. With the improved simulated inductor, the negative influence of the coupling capacitances is overcome and the conductivity measurement is implemented by the series resonance principle. The conductivity measurement experiments are carried out in three pipes with different inner diameters of 3.0 mm, 4.6 mm and 6.4 mm, respectively. The experimental results show that the designs of the new C4D sensor and the improved simulated inductor are successful. The maximum relative error of the conductivity measurement is less than 5%. Compared with the C4D sensors using practical inductors, the measurement accuracy of the new C4D sensor is comparable. The research results also indicate that the adjustability of a simulated inductor can reduce the requirement for the AC source and guarantee the interchangeableness. Meanwhile, it is recommended that making the potential of one terminal of a simulated inductor stable is beneficial to the running stability. Furthermore, this work indirectly verifies the possibility and feasibility of the miniaturization of the C4D sensor by using the simulated inductor technique and lays a good foundation for future research work. PMID:26828493

  20. The observational status of Galileon gravity after Planck

    SciTech Connect

    Barreira, Alexandre; Li, Baojiu; Baugh, Carlton M.; Pascoli, Silvia E-mail: baojiu.li@durham.ac.uk E-mail: silvia.pascoli@durham.ac.uk

    2014-08-01

    We use the latest CMB data from Planck, together with BAO measurements, to constrain the full parameter space of Galileon gravity. We constrain separately the three main branches of the theory known as the Cubic, Quartic and Quintic models, and find that all yield a very good fit to these data. Unlike in ΛCDM, the Galileon model constraints are compatible with local determinations of the Hubble parameter and predict nonzero neutrino masses at over 5σ significance. We also identify that the low l part of the CMB lensing spectrum may be able to distinguish between ΛCDM and Galileon models. In the Cubic model, the lensing potential deepens at late times on sub-horizon scales, which is at odds with the current observational suggestion of a positive ISW effect. Compared to ΛCDM, the Quartic and Quintic models predict less ISW power in the low l region of the CMB temperature spectrum, and as such are slightly preferred by the Planck data. We illustrate that residual local modifications to gravity in the Quartic and Quintic models may render the Cubic model as the only branch of Galileon gravity that passes Solar System tests.

  1. From Planck Constant to Isomorphicity Through Justice Paradox

    NASA Astrophysics Data System (ADS)

    Hidajatullah-Maksoed, Widastra

    2015-05-01

    Robert E. Scott in his ``Chaos theory and the Justice Paradox'', William & Mary Law Review, v 35, I 1, 329 (1993) wrotes''...As we approach the 21-st Century, the signs of social disarray are everywhere. Social critics observe the breakdown of core structure - the nuclear family, schools, neighborhoods & political groups''. For completions for ``soliton'' first coined by Morikazu TODA, comparing the ``Soliton on Scott-Russell aqueduct on the Union Canal near Heriot-WATT University, July 12, 1995 to Michael Stock works: ``a Fine WATT-Balance: Determination of Planck constant & Redefinition of Kilogram'', January 2011, we can concludes the inherencies between `chaos' & `soliton'. Further through ``string theory'' from Michio KAKU sought statements from Peter Mayr: Stringy world brane & Exponential hierarchy'', JHEP 11 (2000): ``if the 5-brane is embedded in flat 10-D space time, the 6-D Planck mass on the brane is infinite'' who also describes the relation of isomorphicity & ``string theory'', from whom denotes the smart city. Replace this text with your abstract body. Incredible acknowledgments to HE. Mr. Drs. P. SWANTORO & HE. Mr. Dr-HC Jakob OETAMA.

  2. Planck 2015 results. XX. Constraints on inflation

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Arroja, F.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Ballardini, M.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chiang, H. C.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Contreras, D.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Frolov, A.; Galeotta, S.; Galli, S.; Ganga, K.; Gauthier, C.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hamann, J.; Handley, W.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huang, Z.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kim, J.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Lewis, A.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Ma, Y.-Z.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Münchmeyer, M.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Pandolfi, S.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Peiris, H. V.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Shiraishi, M.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Trombetti, T.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; White, M.; Yvon, D.; Zacchei, A.; Zibin, J. P.; Zonca, A.

    2016-09-01

    We present the implications for cosmic inflation of the Planck measurements of the cosmic microwave background (CMB) anisotropies in both temperature and polarization based on the full Planck survey, which includes more than twice the integration time of the nominal survey used for the 2013 release papers. The Planck full mission temperature data and a first release of polarization data on large angular scales measure the spectral index of curvature perturbations to be ns = 0.968 ± 0.006 and tightly constrain its scale dependence to dns/ dlnk = -0.003 ± 0.007 when combined with the Planck lensing likelihood. When the Planck high-ℓ polarization data are included, the results are consistent and uncertainties are further reduced. The upper bound on the tensor-to-scalar ratio is r0.002< 0.11 (95% CL). This upper limit is consistent with the B-mode polarization constraint r< 0.12 (95% CL) obtained from a joint analysis of the BICEP2/Keck Array and Planck data. These results imply that V(φ) ∝ φ2 and natural inflation are now disfavoured compared to models predicting a smaller tensor-to-scalar ratio, such as R2 inflation. We search for several physically motivated deviations from a simple power-law spectrum of curvature perturbations, including those motivated by a reconstruction of the inflaton potential not relying on the slow-roll approximation. We find that such models are not preferred, either according to a Bayesian model comparison or according to a frequentist simulation-based analysis. Three independent methods reconstructing the primordial power spectrum consistently recover a featureless and smooth PR(k) over the range of scales 0.008 Mpc-1 ≲ k ≲ 0.1 Mpc-1. At large scales, each method finds deviations from a power law, connected to a deficit at multipoles ℓ ≈ 20-40 in the temperature power spectrum, but at an uncompelling statistical significance owing to the large cosmic variance present at these multipoles. By combining power spectrum and non

  3. A 4D Hyperspherical Interpretation of q-Space

    PubMed Central

    Hosseinbor, A. Pasha; Chung, Moo K.; Wu, Yu-Chien; Alexander, Andrew L.; Bendlin, Barbara B.

    2014-01-01

    3D q-space can be viewed as the surface of a 4D hypersphere. In this paper, we seek to develop a 4D hyperspherical interpretation of q-space by projecting it onto a hypersphere and subsequently modeling the q-space signal via 4D hyperspherical harmonics (HSH). Using this orthonormal basis, we analytically derive several quantitative indices and numerically estimate the diffusion ODF. Importantly, we derive the integral transform describing the relationship between the diffusion signal and propagator on a hypersphere. We also show that the HSH basis expends less fitting parameters than other well-established methods to achieve comparable signal and better ODF reconstructions. All in all, this work provides a new way of looking at q-space. PMID:24505799

  4. Neutrinos help reconcile Planck measurements with the local universe.

    PubMed

    Wyman, Mark; Rudd, Douglas H; Vanderveld, R Ali; Hu, Wayne

    2014-02-01

    Current measurements of the low and high redshift Universe are in tension if we restrict ourselves to the standard six-parameter model of flat ΛCDM. This tension has two parts. First, the Planck satellite data suggest a higher normalization of matter perturbations than local measurements of galaxy clusters. Second, the expansion rate of the Universe today, H0, derived from local distance-redshift measurements is significantly higher than that inferred using the acoustic scale in galaxy surveys and the Planck data as a standard ruler. The addition of a sterile neutrino species changes the acoustic scale and brings the two into agreement; meanwhile, adding mass to the active neutrinos or to a sterile neutrino can suppress the growth of structure, bringing the cluster data into better concordance as well. For our fiducial data set combination, with statistical errors for clusters, a model with a massive sterile neutrino shows 3.5σ evidence for a nonzero mass and an even stronger rejection of the minimal model. A model with massive active neutrinos and a massless sterile neutrino is similarly preferred. An eV-scale sterile neutrino mass--of interest for short baseline and reactor anomalies--is well within the allowed range. We caution that (i) unknown astrophysical systematic errors in any of the data sets could weaken this conclusion, but they would need to be several times the known errors to eliminate the tensions entirely; (ii) the results we find are at some variance with analyses that do not include cluster measurements; and (iii) some tension remains among the data sets even when new neutrino physics is included. PMID:24580585

  5. Neutrinos help reconcile Planck measurements with the local universe.

    PubMed

    Wyman, Mark; Rudd, Douglas H; Vanderveld, R Ali; Hu, Wayne

    2014-02-01

    Current measurements of the low and high redshift Universe are in tension if we restrict ourselves to the standard six-parameter model of flat ΛCDM. This tension has two parts. First, the Planck satellite data suggest a higher normalization of matter perturbations than local measurements of galaxy clusters. Second, the expansion rate of the Universe today, H0, derived from local distance-redshift measurements is significantly higher than that inferred using the acoustic scale in galaxy surveys and the Planck data as a standard ruler. The addition of a sterile neutrino species changes the acoustic scale and brings the two into agreement; meanwhile, adding mass to the active neutrinos or to a sterile neutrino can suppress the growth of structure, bringing the cluster data into better concordance as well. For our fiducial data set combination, with statistical errors for clusters, a model with a massive sterile neutrino shows 3.5σ evidence for a nonzero mass and an even stronger rejection of the minimal model. A model with massive active neutrinos and a massless sterile neutrino is similarly preferred. An eV-scale sterile neutrino mass--of interest for short baseline and reactor anomalies--is well within the allowed range. We caution that (i) unknown astrophysical systematic errors in any of the data sets could weaken this conclusion, but they would need to be several times the known errors to eliminate the tensions entirely; (ii) the results we find are at some variance with analyses that do not include cluster measurements; and (iii) some tension remains among the data sets even when new neutrino physics is included.

  6. Relative charge transfer cross section from Rb (4d)

    NASA Astrophysics Data System (ADS)

    Shah, M. H.; Camp, H. A.; Trachy, M. L.; Fléchard, X.; Gearba, M. A.; Nguyen, H.; Brédy, R.; Lundeen, S. R.; Depaola, B. D.

    2005-08-01

    Relative charge transfer cross section measurements for the excited state Rb(4d) with 7keV Na+ is reported. The specific channels reported are Na++Rb(4d5/2)→Na(nl)+Rb+ , where the dominant transfer cross sections channels were nl=3d and 4s . Using a combination of a magneto-optical trap and recoil ion momentum spectroscopy (MOTRIMS methodology), the cross sections were measured relative to the previously studied Na++Rb(5s,5p) systems at the same collision energy.

  7. Relative charge transfer cross section from Rb(4d)

    SciTech Connect

    Shah, M.H.; Camp, H.A.; Trachy, M.L.; De Paola, B.D.; Flechard, X.; Gearba, M.A.; Nguyen, H.; Bredy, R.; Lundeen, S.R.

    2005-08-15

    Relative charge transfer cross section measurements for the excited state Rb(4d) with 7 keV Na{sup +} is reported. The specific channels reported are Na{sup +}+Rb(4d{sub 5/2}){yields}Na(nl)+Rb{sup +}, where the dominant transfer cross sections channels were nl=3d and 4s. Using a combination of a magneto-optical trap and recoil ion momentum spectroscopy (MOTRIMS methodology), the cross sections were measured relative to the previously studied Na{sup +}+Rb(5s,5p) systems at the same collision energy.

  8. The 4-D approach to visual control of autonomous systems

    NASA Technical Reports Server (NTRS)

    Dickmanns, Ernst D.

    1994-01-01

    Development of a 4-D approach to dynamic machine vision is described. Core elements of this method are spatio-temporal models oriented towards objects and laws of perspective projection in a foward mode. Integration of multi-sensory measurement data was achieved through spatio-temporal models as invariants for object recognition. Situation assessment and long term predictions were allowed through maintenance of a symbolic 4-D image of processes involving objects. Behavioral capabilities were easily realized by state feedback and feed-foward control.

  9. Emerging Applications of Abdominal 4D Flow MRI

    PubMed Central

    Roldán-Alzate, Alejandro; Francois, Christopher J.; Wieben, Oliver; Reeder, Scott B.

    2016-01-01

    OBJECTIVE Comprehensive assessment of abdominal hemodynamics is crucial for many clinical diagnoses but is challenged by a tremendous complexity of anatomy, normal physiology, and a wide variety of pathologic abnormalities. This article introduces 4D flow MRI as a powerful technique for noninvasive assessment of the hemodynamics of abdominal vascular territories. CONCLUSION Four-dimensional flow MRI provides clinicians with a more extensive and straightforward approach to evaluate disorders that affect blood flow in the abdomen. This review presents a series of clinical cases to illustrate the utility of 4D flow MRI in the comprehensive assessment of the abdominal circulation. PMID:27187681

  10. Planck early results. VIII. The all-sky early Sunyaev-Zeldovich cluster sample

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Balbi, A.; Banday, A. J.; Barreiro, R. B.; Bartelmann, M.; Bartlett, J. G.; Battaner, E.; Battye, R.; Benabed, K.; Benoît, A.; Bernard, J.-P.; Bersanelli, M.; Bhatia, R.; Bock, J. J.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Brown, M. L.; Bucher, M.; Burigana, C.; Cabella, P.; Cantalupo, C. M.; Cardoso, J.-F.; Carvalho, P.; Catalano, A.; Cayón, L.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chiang, L.-Y.; Chiang, C.; Chon, G.; Christensen, P. R.; Churazov, E.; Clements, D. L.; Colafrancesco, S.; Colombi, S.; Couchot, F.; Coulais, A.; Crill, B. P.; Cuttaia, F.; da Silva, A.; Dahle, H.; Danese, L.; Davis, R. J.; de Bernardis, P.; de Gasperis, G.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Dörl, U.; Douspis, M.; Dupac, X.; Efstathiou, G.; Eisenhardt, P.; Enßlin, T. A.; Feroz, F.; Finelli, F.; Flores-Cacho, I.; Forni, O.; Fosalba, P.; Frailis, M.; Franceschi, E.; Fromenteau, S.; Galeotta, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Giardino, G.; Giraud-Héraud, Y.; González-Nuevo, J.; González-Riestra, R.; Górski, K. M.; Grainge, K. J. B.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Harrison, D.; Heinämäki, P.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hovest, W.; Hoyland, R. J.; Huffenberger, K. M.; Hurier, G.; Hurley-Walker, N.; Jaffe, A. H.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knox, L.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Laureijs, R. J.; Lawrence, C. R.; Le Jeune, M.; Leach, S.; Leonardi, R.; Li, C.; Liddle, A.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; MacTavish, C. J.; Maffei, B.; Maino, D.; Mandolesi, N.; Mann, R.; Maris, M.; Marleau, F.; Martínez-González, E.; Masi, S.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Mei, S.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Olamaie, M.; Osborne, S.; Pajot, F.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Piffaretti, R.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Poutanen, T.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rubiño-Martín, J. A.; Rusholme, B.; Saar, E.; Sandri, M.; Santos, D.; Saunders, R. D. E.; Savini, G.; Schaefer, B. M.; Scott, D.; Seiffert, M. D.; Shellard, P.; Smoot, G. F.; Stanford, A.; Starck, J.-L.; Stivoli, F.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Sygnet, J.-F.; Taburet, N.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Torre, J.-P.; Tristram, M.; Tuovinen, J.; Valenziano, L.; Vibert, L.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; Weller, J.; White, S. D. M.; White, M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2011-12-01

    We present the first all-sky sample of galaxy clusters detected blindly by the Planck satellite through the Sunyaev-Zeldovich (SZ) effect from its six highest frequencies. This early SZ (ESZ) sample is comprised of 189 candidates, which have a high signal-to-noise ratio ranging from 6 to 29. Its high reliability (purity above 95%) is further ensured by an extensive validation process based on Planck internal quality assessments and by external cross-identification and follow-up observations. Planck provides the first measured SZ signal for about 80% of the 169 previously-known ESZ clusters. Planck furthermore releases 30 new cluster candidates, amongst which 20 meet the ESZ signal-to-noise selection criterion. At the submission date, twelve of the 20 ESZ candidates were confirmed as new clusters, with eleven confirmed using XMM-Newton snapshot observations, most of them with disturbed morphologies and low luminosities. The ESZ clusters are mostly at moderate redshifts (86% with z below 0.3) and span more than a decade in mass, up to the rarest and most massive clusters with masses above 1 × 1015 M⊙. Corresponding author: M. Douspis, e-mail: marian.douspis@ias.u-psud.frAppendix is available in electronic form at http://www.aanda.org

  11. SZ/X-ray scaling relations using X-ray data and Planck Nominal maps

    NASA Astrophysics Data System (ADS)

    De Martino, I.; Atrio-Barandela, F.

    2016-09-01

    We determine the relation between the Comptonization parameter predicted using X-ray data YC, Xray and the X-ray luminosity LX, both magnitudes derived from ROSAT data, with the Comptonization parameter YC, SZ measured on Planck 2013 foreground cleaned Nominal maps. The 560 clusters of our sample includes clusters with masses M ≥ 1013 M⊙, one order of magnitude smaller than those used by the Planck Collaboration in a similar analysis. It also contains eight times more clusters in the redshift interval z ≤ 0.3. The prediction of the β = 2/3 model convolved with the Planck antenna beam agrees with the anisotropies measured in foreground cleaned Planck Nominal maps within the X-ray emitting region, confirming the results of an earlier analysis. The universal pressure profile overestimates the signal by a 15-21 per cent depending on the angular aperture. We show that the discrepancy is not due to the presence of cool-core systems but it is an indication of a brake in the LX - M relation towards low mass systems. We show that relation of the Comptonization parameter averaged over the region that emits 99 per cent of the X-ray flux and and the X-ray luminosity is consistent with the predictions of the self-similar model. We confirm previous findings that the scaling relations studied here do not evolve with redshift within the range probed by our catalogue.

  12. Planck 2015 results. XXIV. Cosmology from Sunyaev-Zeldovich cluster counts

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Bartolo, N.; Battaner, E.; Battye, R.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chiang, H. C.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Comis, B.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Falgarone, E.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Roman, M.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Türler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Weller, J.; White, S. D. M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    We present cluster counts and corresponding cosmological constraints from the Planck full mission data set. Our catalogue consists of 439 clusters detected via their Sunyaev-Zeldovich (SZ) signal down to a signal-to-noise ratio of 6, and is more than a factor of 2 larger than the 2013 Planck cluster cosmology sample. The counts are consistent with those from 2013 and yield compatible constraints under the same modelling assumptions. Taking advantage of the larger catalogue, we extend our analysis to the two-dimensional distribution in redshift and signal-to-noise. We use mass estimates from two recent studies of gravitational lensing of background galaxies by Planck clusters to provide priors on the hydrostatic bias parameter, (1-b). In addition, we use lensing of cosmic microwave background (CMB) temperature fluctuations by Planck clusters as an independent constraint on this parameter. These various calibrations imply constraints on the present-day amplitude of matter fluctuations in varying degrees of tension with those from the Planck analysis of primary fluctuations in the CMB; for the lowest estimated values of (1-b) the tension is mild, only a little over one standard deviation, while it remains substantial (3.7σ) for the largest estimated value. We also examine constraints on extensions to the base flat ΛCDM model by combining the cluster and CMB constraints. The combination appears to favour non-minimal neutrino masses, but this possibility does little to relieve the overall tension because it simultaneously lowers the implied value of the Hubble parameter, thereby exacerbating the discrepancy with most current astrophysical estimates. Improving the precision of cluster mass calibrations from the current 10%-level to 1% would significantly strengthen these combined analyses and provide a stringent test of the base ΛCDM model.

  13. Fokker-Planck response of stochastic satellites

    NASA Technical Reports Server (NTRS)

    Huang, T. C.; Das, A.

    1982-01-01

    The present investigation is concerned with the effects of stochastic geometry and random environmental torques on the pointing accuracy of spinning and three-axis stabilized satellites. The study of pointing accuracies requires a knowledge of the rates of error growth over and above any criteria for the asymptotic stability of the satellites. For this reason the investigation is oriented toward the determination of the statistical properties of the responses of the satellites. The geometries of the satellites are considered stochastic so as to have a phenomenological model of the motions of the flexible structural elements of the satellites. A widely used method of solving stochastic equations is the Fokker-Planck approach where the equations are assumed to define a Markoff process and the transition probability densities of the responses are computed directly as a function of time. The Fokker-Planck formulation is used to analyze the response vector of a rigid satellite.

  14. Does Planck really rule out monomial inflation?

    SciTech Connect

    Enqvist, Kari; Karčiauskas, Mindaugas E-mail: mindaugas.karciauskas@helsinki.fi

    2014-02-01

    We consider the modifications of monomial chaotic inflation models due to radiative corrections induced by inflaton couplings to bosons and/or fermions necessary for reheating. To the lowest order, ignoring gravitational corrections and treating the inflaton as a classical background field, they are of the Coleman-Weinberg type and parametrized by the renormalization scale μ. In cosmology, there are not enough measurements to fix μ so that we end up with a family of models, each having a slightly different slope of the potential. We demonstrate by explicit calculation that within the family of chaotic φ{sup 2} models, some may be ruled out by Planck whereas some remain perfectly viable. In contrast, radiative corrections do not seem to help chaotic φ{sup 4} models to meet the Planck constraints.

  15. 2,4-Dichlorophenoxyacetic acid (2,4-D)

    Integrated Risk Information System (IRIS)

    2,4 - Dichlorophenoxyacetic acid ( 2,4 - D ) ; CASRN 94 - 75 - 7 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Asses

  16. Enterococcus faecalis promotes osteoclastogenesis and semaphorin 4D expression.

    PubMed

    Wang, Shuai; Deng, Zuhui; Seneviratne, Chaminda J; Cheung, Gary S P; Jin, Lijian; Zhao, Baohong; Zhang, Chengfei

    2015-10-01

    Enterococcus faecalis is considered a major bacterial pathogen implicated in endodontic infections and contributes considerably to periapical periodontitis. This study aimed to investigate the potential mechanisms by which E. faecalis accounts for the bone destruction in periapical periodontitis in vitro. Osteoclast precursor RAW264.7 cells were treated with E. faecalis ATCC 29212 and a wild strain of E. faecalis derived clinically from an infected root canal. The results showed that, to some extent, E. faecalis induced the RAW264.7 cells to form tartrate-resistant acid phosphatase (TRAP)-positive multinucleated osteoclast-like cells. This pathogen markedly stimulated RAW264.7 cells to express semaphorin 4D (Sema4D), which inhibits bone formation. Once RAW264.7 cells were primed by low-dose receptor activator of nuclear factor-kappa B ligand (RANKL), E. faecalis could significantly increase the production of TRAP-positive multinucleated cells and up-regulate the expression of osteoclast-specific markers, including NFATc1, TRAP and cathepsin K. Both p38 and ERK1/2 MAPK signaling pathways were activated by E. faecalis in RANKL-primed RAW264.7 cells, and meanwhile the expression of Sema4D was highly increased. In conclusion, E. faecalis may greatly contribute to the bone resorption in periapical periodontitis by promoting RANKL-dependent osteoclastogenesis and expression of Sema4D through activation of p38 and ERK1/2 MAPK signaling pathways.

  17. 4D flow mri post-processing strategies for neuropathologies

    NASA Astrophysics Data System (ADS)

    Schrauben, Eric Mathew

    4D flow MRI allows for the measurement of a dynamic 3D velocity vector field. Blood flow velocities in large vascular territories can be qualitatively visualized with the added benefit of quantitative probing. Within cranial pathologies theorized to have vascular-based contributions or effects, 4D flow MRI provides a unique platform for comprehensive assessment of hemodynamic parameters. Targeted blood flow derived measurements, such as flow rate, pulsatility, retrograde flow, or wall shear stress may provide insight into the onset or characterization of more complex neuropathologies. Therefore, the thorough assessment of each parameter within the context of a given disease has important medical implications. Not surprisingly, the last decade has seen rapid growth in the use of 4D flow MRI. Data acquisition sequences are available to researchers on all major scanner platforms. However, the use has been limited mostly to small research trials. One major reason that has hindered the more widespread use and application in larger clinical trials is the complexity of the post-processing tasks and the lack of adequate tools for these tasks. Post-processing of 4D flow MRI must be semi-automated, fast, user-independent, robust, and reliably consistent for use in a clinical setting, within large patient studies, or across a multicenter trial. Development of proper post-processing methods coupled with systematic investigation in normal and patient populations pushes 4D flow MRI closer to clinical realization while elucidating potential underlying neuropathological origins. Within this framework, the work in this thesis assesses venous flow reproducibility and internal consistency in a healthy population. A preliminary analysis of venous flow parameters in healthy controls and multiple sclerosis patients is performed in a large study employing 4D flow MRI. These studies are performed in the context of the chronic cerebrospinal venous insufficiency hypothesis. Additionally, a

  18. Planck 2015 results. V. LFI calibration

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Battaglia, P.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Chamballu, A.; Christensen, P. R.; Colombi, S.; Colombo, L. P. L.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Dickinson, C.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Knoche, J.; Krachmalnicoff, N.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leahy, J. P.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Novikov, D.; Novikov, I.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Peel, M.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Pierpaoli, E.; Pietrobon, D.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renzi, A.; Rocha, G.; Romelli, E.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Tavagnacco, D.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Türler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vassallo, T.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Watson, R.; Wehus, I. K.; Wilkinson, A.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-08-01

    We present a description of the pipeline used to calibrate the Planck Low Frequency Instrument (LFI) timelines into thermodynamic temperatures for the Planck 2015 data release, covering four years of uninterrupted operations. As in the 2013 data release, our calibrator is provided by the spin-synchronous modulation of the cosmic microwave background dipole, but we now use the orbital component, rather than adopting the Wilkinson Microwave Anisotropy Probe (WMAP) solar dipole. This allows our 2015 LFI analysis to provide an independent Solar dipole estimate, which is in excellent agreement with that of HFI and within 1σ (0.3% in amplitude) of the WMAP value. This 0.3% shift in the peak-to-peak dipole temperature from WMAP and a general overhaul of the iterative calibration code increases the overall level of the LFI maps by 0.45% (30 GHz), 0.64% (44 GHz), and 0.82% (70 GHz) in temperature with respect to the 2013 Planck data release, thus reducing the discrepancy with the power spectrum measured by WMAP. We estimate that the LFI calibration uncertainty is now at the level of 0.20% for the 70 GHz map, 0.26% for the 44 GHz map, and 0.35% for the 30 GHz map. We provide a detailed description of the impact of all the changes implemented in the calibration since the previous data release.

  19. SPECTRAL IMAGING OF GALAXY CLUSTERS WITH PLANCK

    SciTech Connect

    Bourdin, H.; Mazzotta, P.; Rasia, E.

    2015-12-20

    The Sunyaev–Zeldovich (SZ) effect is a promising tool for detecting the presence of hot gas out to the galaxy cluster peripheries. We developed a spectral imaging algorithm dedicated to the SZ observations of nearby galaxy clusters with Planck, with the aim of revealing gas density anisotropies related to the filamentary accretion of materials, or pressure discontinuities induced by the propagation of shock fronts. To optimize an unavoidable trade-off between angular resolution and precision of the SZ flux measurements, the algorithm performs a multi-scale analysis of the SZ maps as well as of other extended components, such as the cosmic microwave background (CMB) anisotropies and the Galactic thermal dust. The demixing of the SZ signal is tackled through kernel-weighted likelihood maximizations. The CMB anisotropies are further analyzed through a wavelet analysis, while the Galactic foregrounds and SZ maps are analyzed via a curvelet analysis that best preserves their anisotropic details. The algorithm performance has been tested against mock observations of galaxy clusters obtained by simulating the Planck High Frequency Instrument and by pointing at a few characteristic positions in the sky. These tests suggest that Planck should easily allow us to detect filaments in the cluster peripheries and detect large-scale shocks in colliding galaxy clusters that feature favorable geometry.

  20. 4D MR imaging using robust internal respiratory signal

    NASA Astrophysics Data System (ADS)

    Hui, CheukKai; Wen, Zhifei; Stemkens, Bjorn; Tijssen, R. H. N.; van den Berg, C. A. T.; Hwang, Ken-Pin; Beddar, Sam

    2016-05-01

    The purpose of this study is to investigate the feasibility of using internal respiratory (IR) surrogates to sort four-dimensional (4D) magnetic resonance (MR) images. The 4D MR images were constructed by acquiring fast 2D cine MR images sequentially, with each slice scanned for more than one breathing cycle. The 4D volume was then sorted retrospectively using the IR signal. In this study, we propose to use multiple low-frequency components in the Fourier space as well as the anterior body boundary as potential IR surrogates. From these potential IR surrogates, we used a clustering algorithm to identify those that best represented the respiratory pattern to derive the IR signal. A study with healthy volunteers was performed to assess the feasibility of the proposed IR signal. We compared this proposed IR signal with the respiratory signal obtained using respiratory bellows. Overall, 99% of the IR signals matched the bellows signals. The average difference between the end inspiration times in the IR signal and bellows signal was 0.18 s in this cohort of matching signals. For the acquired images corresponding to the other 1% of non-matching signal pairs, the respiratory motion shown in the images was coherent with the respiratory phases determined by the IR signal, but not the bellows signal. This suggested that the IR signal determined by the proposed method could potentially correct the faulty bellows signal. The sorted 4D images showed minimal mismatched artefacts and potential clinical applicability. The proposed IR signal therefore provides a feasible alternative to effectively sort MR images in 4D.

  1. Poisson–Boltzmann–Nernst–Planck model

    PubMed Central

    Zheng, Qiong; Wei, Guo-Wei

    2011-01-01

    The Poisson–Nernst–Planck (PNP) model is based on a mean-field approximation of ion interactions and continuum descriptions of concentration and electrostatic potential. It provides qualitative explanation and increasingly quantitative predictions of experimental measurements for the ion transport problems in many areas such as semiconductor devices, nanofluidic systems, and biological systems, despite many limitations. While the PNP model gives a good prediction of the ion transport phenomenon for chemical, physical, and biological systems, the number of equations to be solved and the number of diffusion coefficient profiles to be determined for the calculation directly depend on the number of ion species in the system, since each ion species corresponds to one Nernst–Planck equation and one position-dependent diffusion coefficient profile. In a complex system with multiple ion species, the PNP can be computationally expensive and parameter demanding, as experimental measurements of diffusion coefficient profiles are generally quite limited for most confined regions such as ion channels, nanostructures and nanopores. We propose an alternative model to reduce number of Nernst–Planck equations to be solved in complex chemical and biological systems with multiple ion species by substituting Nernst–Planck equations with Boltzmann distributions of ion concentrations. As such, we solve the coupled Poisson–Boltzmann and Nernst–Planck (PBNP) equations, instead of the PNP equations. The proposed PBNP equations are derived from a total energy functional by using the variational principle. We design a number of computational techniques, including the Dirichlet to Neumann mapping, the matched interface and boundary, and relaxation based iterative procedure, to ensure efficient solution of the proposed PBNP equations. Two protein molecules, cytochrome c551 and Gramicidin A, are employed to validate the proposed model under a wide range of bulk ion concentrations

  2. Poisson-Boltzmann-Nernst-Planck model

    NASA Astrophysics Data System (ADS)

    Zheng, Qiong; Wei, Guo-Wei

    2011-05-01

    The Poisson-Nernst-Planck (PNP) model is based on a mean-field approximation of ion interactions and continuum descriptions of concentration and electrostatic potential. It provides qualitative explanation and increasingly quantitative predictions of experimental measurements for the ion transport problems in many areas such as semiconductor devices, nanofluidic systems, and biological systems, despite many limitations. While the PNP model gives a good prediction of the ion transport phenomenon for chemical, physical, and biological systems, the number of equations to be solved and the number of diffusion coefficient profiles to be determined for the calculation directly depend on the number of ion species in the system, since each ion species corresponds to one Nernst-Planck equation and one position-dependent diffusion coefficient profile. In a complex system with multiple ion species, the PNP can be computationally expensive and parameter demanding, as experimental measurements of diffusion coefficient profiles are generally quite limited for most confined regions such as ion channels, nanostructures and nanopores. We propose an alternative model to reduce number of Nernst-Planck equations to be solved in complex chemical and biological systems with multiple ion species by substituting Nernst-Planck equations with Boltzmann distributions of ion concentrations. As such, we solve the coupled Poisson-Boltzmann and Nernst-Planck (PBNP) equations, instead of the PNP equations. The proposed PBNP equations are derived from a total energy functional by using the variational principle. We design a number of computational techniques, including the Dirichlet to Neumann mapping, the matched interface and boundary, and relaxation based iterative procedure, to ensure efficient solution of the proposed PBNP equations. Two protein molecules, cytochrome c551 and Gramicidin A, are employed to validate the proposed model under a wide range of bulk ion concentrations and external

  3. Poisson-Boltzmann-Nernst-Planck model

    SciTech Connect

    Zheng Qiong; Wei Guowei

    2011-05-21

    The Poisson-Nernst-Planck (PNP) model is based on a mean-field approximation of ion interactions and continuum descriptions of concentration and electrostatic potential. It provides qualitative explanation and increasingly quantitative predictions of experimental measurements for the ion transport problems in many areas such as semiconductor devices, nanofluidic systems, and biological systems, despite many limitations. While the PNP model gives a good prediction of the ion transport phenomenon for chemical, physical, and biological systems, the number of equations to be solved and the number of diffusion coefficient profiles to be determined for the calculation directly depend on the number of ion species in the system, since each ion species corresponds to one Nernst-Planck equation and one position-dependent diffusion coefficient profile. In a complex system with multiple ion species, the PNP can be computationally expensive and parameter demanding, as experimental measurements of diffusion coefficient profiles are generally quite limited for most confined regions such as ion channels, nanostructures and nanopores. We propose an alternative model to reduce number of Nernst-Planck equations to be solved in complex chemical and biological systems with multiple ion species by substituting Nernst-Planck equations with Boltzmann distributions of ion concentrations. As such, we solve the coupled Poisson-Boltzmann and Nernst-Planck (PBNP) equations, instead of the PNP equations. The proposed PBNP equations are derived from a total energy functional by using the variational principle. We design a number of computational techniques, including the Dirichlet to Neumann mapping, the matched interface and boundary, and relaxation based iterative procedure, to ensure efficient solution of the proposed PBNP equations. Two protein molecules, cytochrome c551 and Gramicidin A, are employed to validate the proposed model under a wide range of bulk ion concentrations and external

  4. Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene.

    PubMed Central

    Bolger, G B; Erdogan, S; Jones, R E; Loughney, K; Scotland, G; Hoffmann, R; Wilkinson, I; Farrell, C; Houslay, M D

    1997-01-01

    We have isolated and characterized complete cDNAs for two isoforms (HSPDE4D4 and HSPDE4A5) encoded by the human PDE4D gene, one of four genes that encode cAMP-specific rolipram-inhibited 3',5'-cyclic nucleotide phosphodiesterases (type IVPDEs; PDE4 family). The HSPDE4D4 and HSPDE4D5 cDNAs encode proteins of 810 and 746 amino acids respectively. A comparison of the nucleotide sequences of these two cDNAs with those encoding the three other human PDE4D proteins (HSPDE4D1, HSPDE4D2 and HSPDE4D3) demonstrates that each corresponding mRNA transcript has a unique region of sequence at or near its 5'-end, consistent with alternative mRNA splicing. Transient expression of the five cDNAs in monkey COS-7 cells produced proteins of apparent molecular mass under denaturing conditions of 68, 68, 95, 119 and 105 kDa for isoforms HSPDE4D1-5 respectively. Immunoblotting of human cell lines and rat brain demonstrated the presence of species that co-migrated with the proteins produced in COS-7 cells. COS-cell-expressed and native HSPDE4D1 and HSPDE4D2 were found to exist only in the cytosol, whereas HSPDE4D3, HSPDE4D4 and HSPDE4D5 were found in both cytosolic and particulate fractions. The IC50 values for the selective PDE4 inhibitor rolipram for the cytosolic forms of the five enzymes were similar (0.05-0.14 microM), whereas they were 2-7-fold higher for the particulate forms of HSPDE4D3 and HSPDE4D5 (0.32 and 0.59 microM respectively), than for the corresponding cytosolic forms. Our data indicate that the N-terminal regions of the HSPDE4D3, HSPDE4D4 and HSPDE4D5 proteins, which are derived from alternatively spliced regions of their mRNAs, are important in determining their subcellular localization, activity and differential sensitivity to inhibitors. PMID:9371713

  5. Mass

    SciTech Connect

    Quigg, Chris

    2007-12-05

    In the classical physics we inherited from Isaac Newton, mass does not arise, it simply is. The mass of a classical object is the sum of the masses of its parts. Albert Einstein showed that the mass of a body is a measure of its energy content, inviting us to consider the origins of mass. The protons we accelerate at Fermilab are prime examples of Einsteinian matter: nearly all of their mass arises from stored energy. Missing mass led to the discovery of the noble gases, and a new form of missing mass leads us to the notion of dark matter. Starting with a brief guided tour of the meanings of mass, the colloquium will explore the multiple origins of mass. We will see how far we have come toward understanding mass, and survey the issues that guide our research today.

  6. Impact of incorporating visual biofeedback in 4D MRI.

    PubMed

    To, David T; Kim, Joshua P; Price, Ryan G; Chetty, Indrin J; Glide-Hurst, Carri K

    2016-05-08

    Precise radiation therapy (RT) for abdominal lesions is complicated by respiratory motion and suboptimal soft tissue contrast in 4D CT. 4D MRI offers improved con-trast although long scan times and irregular breathing patterns can be limiting. To address this, visual biofeedback (VBF) was introduced into 4D MRI. Ten volunteers were consented to an IRB-approved protocol. Prospective respiratory-triggered, T2-weighted, coronal 4D MRIs were acquired on an open 1.0T MR-SIM. VBF was integrated using an MR-compatible interactive breath-hold control system. Subjects visually monitored their breathing patterns to stay within predetermined tolerances. 4D MRIs were acquired with and without VBF for 2- and 8-phase acquisitions. Normalized respiratory waveforms were evaluated for scan time, duty cycle (programmed/acquisition time), breathing period, and breathing regularity (end-inhale coefficient of variation, EI-COV). Three reviewers performed image quality assessment to compare artifacts with and without VBF. Respiration-induced liver motion was calculated via centroid difference analysis of end-exhale (EE) and EI liver contours. Incorporating VBF reduced 2-phase acquisition time (4.7 ± 1.0 and 5.4 ± 1.5 min with and without VBF, respectively) while reducing EI-COV by 43.8% ± 16.6%. For 8-phase acquisitions, VBF reduced acquisition time by 1.9 ± 1.6 min and EI-COVs by 38.8% ± 25.7% despite breathing rate remaining similar (11.1 ± 3.8 breaths/min with vs. 10.5 ± 2.9 without). Using VBF yielded higher duty cycles than unguided free breathing (34.4% ± 5.8% vs. 28.1% ± 6.6%, respectively). Image grading showed that out of 40 paired evaluations, 20 cases had equivalent and 17 had improved image quality scores with VBF, particularly for mid-exhale and EI. Increased liver excursion was observed with VBF, where superior-inferior, anterior-posterior, and left-right EE-EI displacements were 14.1± 5.8, 4.9 ± 2.1, and 1.5 ± 1.0 mm, respectively, with VBF compared to 11.9

  7. Planck early results. XI. Calibration of the local galaxy cluster Sunyaev-Zeldovich scaling relations

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Balbi, A.; Banday, A. J.; Barreiro, R. B.; Bartelmann, M.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Benoît, A.; Bernard, J.-P.; Bersanelli, M.; Bhatia, R.; Bock, J. J.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bourdin, H.; Brown, M. L.; Bucher, M.; Burigana, C.; Cabella, P.; Cardoso, J.-F.; Catalano, A.; Cayón, L.; Challinor, A.; Chamballu, A.; Chiang, L.-Y.; Chiang, C.; Chon, G.; Christensen, P. R.; Churazov, E.; Clements, D. L.; Colafrancesco, S.; Colombi, S.; Couchot, F.; Coulais, A.; Crill, B. P.; Cuttaia, F.; da Silva, A.; Dahle, H.; Danese, L.; de Bernardis, P.; de Gasperis, G.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Diego, J. M.; Dolag, K.; Donzelli, S.; Doré, O.; Dörl, U.; Douspis, M.; Dupac, X.; Efstathiou, G.; Enßlin, T. A.; Finelli, F.; Flores-Cacho, I.; Forni, O.; Frailis, M.; Franceschi, E.; Fromenteau, S.; Galeotta, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Giardino, G.; Giraud-Héraud, Y.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Harrison, D.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hovest, W.; Hoyland, R. J.; Huffenberger, K. M.; Jaffe, A. H.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knox, L.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lanoux, J.; Lasenby, A.; Laureijs, R. J.; Lawrence, C. R.; Leach, S.; Leonardi, R.; Liddle, A.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; MacTavish, C. J.; Maffei, B.; Maino, D.; Mandolesi, N.; Mann, R.; Maris, M.; Marleau, F.; Martínez-González, E.; Masi, S.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, A.; Naselsky, P.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Osborne, S.; Pajot, F.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Piffaretti, R.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Poutanen, T.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savini, G.; Schaefer, B. M.; Scott, D.; Seiffert, M. D.; Shellard, P.; Smoot, G. F.; Starck, J.-L.; Stivoli, F.; Stolyarov, V.; Sudiwala, R.; Sunyaev, R.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Torre, J.-P.; Tristram, M.; Tuovinen, J.; Valenziano, L.; Vibert, L.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; White, S. D. M.; White, M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2011-12-01

    We present precise Sunyaev-Zeldovich (SZ) effect measurements in the direction of 62 nearby galaxy clusters (z < 0.5) detected at high signal-to-noise in the first Planck all-sky data set. The sample spans approximately a decade in total mass, 2 × 1014 M⊙ < M500 < 2 × 1015 M⊙, where M500 is the mass corresponding to a total density contrast of 500. Combining these high quality Planck measurements with deep XMM-Newton X-ray data, we investigate the relations between DA2 Y500, the integrated Compton parameter due to the SZ effect, and the X-ray-derived gas mass Mg,500, temperature TX, luminosity LX,500, SZ signal analogue YX,500 = Mg,500 × TX, and total mass M500. After correction for the effect of selection bias on the scaling relations, we find results that are in excellent agreement with both X-ray predictions and recently-published ground-based data derived from smaller samples. The present data yield an exceptionally robust, high-quality local reference, and illustrate Planck's unique capabilities for all-sky statistical studies of galaxy clusters. Corresponding author: G. W. Pratt, e-mail: gabriel.pratt@cea.fr

  8. Exome sequencing identifies PDE4D mutations in acrodysostosis.

    PubMed

    Lee, Hane; Graham, John M; Rimoin, David L; Lachman, Ralph S; Krejci, Pavel; Tompson, Stuart W; Nelson, Stanley F; Krakow, Deborah; Cohn, Daniel H

    2012-04-01

    Acrodysostosis is a dominantly-inherited, multisystem disorder characterized by skeletal, endocrine, and neurological abnormalities. To identify the molecular basis of acrodysostosis, we performed exome sequencing on five genetically independent cases. Three different missense mutations in PDE4D, which encodes cyclic AMP (cAMP)-specific phosphodiesterase 4D, were found to be heterozygous in three of the cases. Two of the mutations were demonstrated to have occurred de novo, providing strong genetic evidence of causation. Two additional cases were heterozygous for de novo missense mutations in PRKAR1A, which encodes the cAMP-dependent regulatory subunit of protein kinase A and which has been recently reported to be the cause of a form of acrodysostosis resistant to multiple hormones. These findings demonstrate that acrodysostosis is genetically heterogeneous and underscore the exquisite sensitivity of many tissues to alterations in cAMP homeostasis. PMID:22464252

  9. Intelligent Vehicle Systems: A 4D/RCS Approach

    SciTech Connect

    Madhavan, Raj

    2007-04-01

    This book presents new research on autonomous mobility capabilities and shows how technological advances can be anticipated in the coming two decades. An in-depth description is presented on the theoretical foundations and engineering approaches that enable these capabilities. Chapter 1 provides a brief introduction to the 4D/RCS reference model architecture and design methodology that has proven successful in guiding the development of autonomous mobility systems. Chapters 2 through 7 provide more detailed descriptions of research that has been conducted and algorithms that have been developed to implement the various aspects of the 4D/RCS reference model architecture and design methodology. Chapters 8 and 9 discuss applications, performance measures, and standards. Chapter 10 provides a history of Army and DARPA research in autonomous ground mobility. Chapter 11 provides a perspective on the potential future developments in autonomous mobility.

  10. Brain tissue segmentation in 4D CT using voxel classification

    NASA Astrophysics Data System (ADS)

    van den Boom, R.; Oei, M. T. H.; Lafebre, S.; Oostveen, L. J.; Meijer, F. J. A.; Steens, S. C. A.; Prokop, M.; van Ginneken, B.; Manniesing, R.

    2012-02-01

    A method is proposed to segment anatomical regions of the brain from 4D computer tomography (CT) patient data. The method consists of a three step voxel classification scheme, each step focusing on structures that are increasingly difficult to segment. The first step classifies air and bone, the second step classifies vessels and the third step classifies white matter, gray matter and cerebrospinal fluid. As features the time averaged intensity value and the temporal intensity change value were used. In each step, a k-Nearest-Neighbor classifier was used to classify the voxels. Training data was obtained by placing regions of interest in reconstructed 3D image data. The method has been applied to ten 4D CT cerebral patient data. A leave-one-out experiment showed consistent and accurate segmentation results.

  11. 4D embryonic cardiography using gated optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Jenkins, M. W.; Rothenberg, F.; Roy, D.; Nikolski, V. P.; Hu, Z.; Watanabe, M.; Wilson, D. L.; Efimov, I. R.; Rollins, A. M.

    2006-01-01

    Simultaneous imaging of very early embryonic heart structure and function has technical limitations of spatial and temporal resolution. We have developed a gated technique using optical coherence tomography (OCT) that can rapidly image beating embryonic hearts in four-dimensions (4D), at high spatial resolution (10-15 μm), and with a depth penetration of 1.5 - 2.0 mm that is suitable for the study of early embryonic hearts. We acquired data from paced, excised, embryonic chicken and mouse hearts using gated sampling and employed image processing techniques to visualize the hearts in 4D and measure physiologic parameters such as cardiac volume, ejection fraction, and wall thickness. This technique is being developed to longitudinally investigate the physiology of intact embryonic hearts and events that lead to congenital heart defects.

  12. Digit ratio (2D:4D) predicts sporting success among female fencers independent from physical, experience, and personality factors.

    PubMed

    Voracek, M; Reimer, B; Dressler, S G

    2010-12-01

    Research particularly focusing on male athletes and popular sports (running and soccer) suggests associations of lower (masculinized) second-to-fourth digit ratio (2D:4D), a putative marker of prenatal androgen action, with better sports performance. Studies focusing on women, non-mainstream sports, or controlling for covariates relevant for sporting success are still sparse. This study examined associations between 2D:4D and performance of both male and female athletes active in fencing (a non-mainstream sport dominated by male participants), while controlling for covariates. National fencing rankings and 2D:4D of 58 male and 41 female Austrian tournament fencers (mean age 24 years) were correlated. Among female, but not male, fencers, lower 2D:4D was related to better national fencing rankings. 2D:4D still accounted for incremental variance (12%) in fencing success, when the effects of salient performance factors (age, body mass index, years of fencing, training intensity, and the personality variables achievement, control, harm avoidance, and social potency) were controlled for (totaling 35% attributable variance). Athletes active in the most aggressive form (the sabre) had lower 2D:4D than those active in the other forms (épée and foil fencing). Sporting success in adult life might be partly prenatally programmed via long-lasting extragenital effects of testosterone. PMID:19843265

  13. 4D flow cardiovascular magnetic resonance consensus statement.

    PubMed

    Dyverfeldt, Petter; Bissell, Malenka; Barker, Alex J; Bolger, Ann F; Carlhäll, Carl-Johan; Ebbers, Tino; Francios, Christopher J; Frydrychowicz, Alex; Geiger, Julia; Giese, Daniel; Hope, Michael D; Kilner, Philip J; Kozerke, Sebastian; Myerson, Saul; Neubauer, Stefan; Wieben, Oliver; Markl, Michael

    2015-01-01

    Pulsatile blood flow through the cavities of the heart and great vessels is time-varying and multidirectional. Access to all regions, phases and directions of cardiovascular flows has formerly been limited. Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) has enabled more comprehensive access to such flows, with typical spatial resolution of 1.5×1.5×1.5 - 3×3×3 mm(3), typical temporal resolution of 30-40 ms, and acquisition times in the order of 5 to 25 min. This consensus paper is the work of physicists, physicians and biomedical engineers, active in the development and implementation of 4D Flow CMR, who have repeatedly met to share experience and ideas. The paper aims to assist understanding of acquisition and analysis methods, and their potential clinical applications with a focus on the heart and greater vessels. We describe that 4D Flow CMR can be clinically advantageous because placement of a single acquisition volume is straightforward and enables flow through any plane across it to be calculated retrospectively and with good accuracy. We also specify research and development goals that have yet to be satisfactorily achieved. Derived flow parameters, generally needing further development or validation for clinical use, include measurements of wall shear stress, pressure difference, turbulent kinetic energy, and intracardiac flow components. The dependence of measurement accuracy on acquisition parameters is considered, as are the uses of different visualization strategies for appropriate representation of time-varying multidirectional flow fields. Finally, we offer suggestions for more consistent, user-friendly implementation of 4D Flow CMR acquisition and data handling with a view to multicenter studies and more widespread adoption of the approach in routine clinical investigations. PMID:26257141

  14. Phosphodiesterase 4D gene polymorphisms in sudden sensorineural hearing loss.

    PubMed

    Chien, Chen-Yu; Tai, Shu-Yu; Wang, Ling-Feng; Hsi, Edward; Chang, Ning-Chia; Wang, Hsun-Mo; Wu, Ming-Tsang; Ho, Kuen-Yao

    2016-09-01

    The phosphodiesterase 4D (PDE4D) gene has been reported as a risk gene for ischemic stroke. The vascular factors are between the hypothesized etiologies of sudden sensorineural hearing loss (SSNHL), and this genetic effect might be attributed for its role in SSNHL. We hypothesized that genetic variants of the PDE4D gene are associated with susceptibility to SSNHL. We conducted a case-control study with 362 SSNHL cases and 209 controls. Three single nucleotide polymorphisms (SNPs) were selected. The genotypes were determined using TaqMan technology. Hardy-Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. We carried out sex-specific analysis to analyze the overall data. All three SNPs were in HWE. When subjects were stratified by sex, the genetic effect was only evident in females but not in males. The TT genotype of rs702553 exhibited an adjusted odds ratio (OR) of 3.83 (95 % confidence interval = 1.46-11.18) (p = 0.006) in female SSNHL. The TT genotype of SNP rs702553 was associated with female SSNHL under the recessive model (p = 0.004, OR 3.70). In multivariate logistic regression analysis, TT genotype of rs702553 was significantly associated with female SSNHL (p = 0.0043, OR 3.70). These results suggest that PDE4D gene polymorphisms influence the susceptibility for the development of SSNHL in the southern Taiwanese female population.

  15. A 4D Hyperspherical Interpretation of q-Space

    PubMed Central

    Hosseinbor, A. Pasha; Chung, Moo K.; Wu, Yu-Chien; Bendlin, Barbara B.; Alexander, Andrew L.

    2015-01-01

    3D q-space can be viewed as the surface of a 4D hypersphere. In this paper, we seek to develop a 4D hyperspherical interpretation of q-space by projecting it onto a hypersphere and subsequently modeling the q-space signal via 4D hyperspherical harmonics (HSH). Using this orthonormal basis, we derive several well-established q-space indices and numerically estimate the diffusion orientation distribution function (dODF). We also derive the integral transform describing the relationship between the diffusion signal and propagator on a hypersphere. Most importantly, we will demonstrate that for hybrid diffusion imaging (HYDI) acquisitions low order linear expansion of the HSH basis is sufficient to characterize diffusion in neural tissue. In fact, the HSH basis achieves comparable signal and better dODF reconstructions than other well-established methods, such as Bessel Fourier orientation reconstruction (BFOR), using fewer fitting parameters. All in all, this work provides a new way of looking at q-space. PMID:25624043

  16. 4D-Flow validation, numerical and experimental framework

    NASA Astrophysics Data System (ADS)

    Sansom, Kurt; Liu, Haining; Canton, Gador; Aliseda, Alberto; Yuan, Chun

    2015-11-01

    This work presents a group of assessment metrics of new 4D MRI flow sequences, an imaging modality that allows for visualization of three-dimensional pulsatile flow in the cardiovascular anatomy through time-resolved three-dimensional blood velocity measurements from cardiac-cycle synchronized MRI acquisition. This is a promising tool for clinical assessment but lacks a robust validation framework. First, 4D-MRI flow in a subject's stenotic carotid bifurcation is compared with a patient-specific CFD model using two different boundary condition methods. Second, Particle Image Velocimetry in a patient-specific phantom is used as a benchmark to compare the 4D-MRI in vivo measurements and CFD simulations under the same conditions. Comparison of estimated and measureable flow parameters such as wall shear stress, fluctuating velocity rms, Lagrangian particle residence time, will be discussed, with justification for their biomechanics relevance and the insights they can provide on the pathophysiology of arterial disease: atherosclerosis and intimal hyperplasia. Lastly, the framework is applied to a new sequence to provide a quantitative assessment. A parametric analysis on the carotid bifurcation pulsatile flow conditions will be presented and an accuracy assessment provided.

  17. Max-Planck-Institut für Astrophysik

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    The Max-Planck-Institut für Astrophysik, now located in the town of Garching north of Munich in Germany, is one of the more than 70 autonomous research institutes of the Max-Planck-Gesellschaft. It was founded in 1958 under the direction of Ludwig Biermann as part of the Max-Planck-Institut für Physik und Astrophysik, directed at that time by Werner Heisenberg. In 1979, when the headquarters of t...

  18. Fokker-Planck equation in mirror research

    SciTech Connect

    Post, R.F.

    1983-08-11

    Open confinement systems based on the magnetic mirror principle depend on the maintenance of particle distributions that may deviate substantially from Maxwellian distributions. Mirror research has therefore from the beginning relied on theoretical predictions of non-equilibrium rate processes obtained from solutions to the Fokker-Planck equation. The F-P equation plays three roles: Design of experiments, creation of classical standards against which to compare experiment, and predictions concerning mirror based fusion power systems. Analytical and computational approaches to solving the F-P equation for mirror systems will be reviewed, together with results and examples that apply to specific mirror systems, such as the tandem mirror.

  19. Kähler potentials for Planck inflation

    SciTech Connect

    Roest, Diederik; Scalisi, Marco; Zavala, Ivonne E-mail: m.scalisi@rug.nl

    2013-11-01

    We assess which Kähler potentials in supergravity lead to viable single-field inflationary models that are consistent with Planck. We highlight the role of symmetries, such as shift, Heisenberg and supersymmetry, in these constructions. Also the connections to string theory are pointed out. Finally, we discuss a supergravity model for arbitrary inflationary potentials that is suitable for open string inflation and generalise it to the case of closed string inflation. Our model includes the recently discussed supergravity reformulation of the Starobinsky model of inflation as well as an interesting alternative with comparable predictions.

  20. AN ENZYME LINKED IMMUNOSORBENT ASSAY (ELISA) METHOD FOR MONITORING 2,4 DICHLOROPHENOXYACETIC ACID (2,4-D) EXPOSURES

    EPA Science Inventory

    Abstract describes a streamlined ELISA method developed to quantitatively measure 2,4-D in human urine samples. Method development steps and comparison with gas chromatography/mass spectrometry are presented. Results indicated that the ELISA method could be used as a high throu...

  1. Ultra-large distance modification of gravity from Lorentz symmetry breaking at the Planck scale

    NASA Astrophysics Data System (ADS)

    Gorbunov, Dmitry S.; Sibiryakov, Sergei M.

    2005-09-01

    We present an extension of the Randall-Sundrum model in which, due to spontaneous Lorentz symmetry breaking, graviton mixes with bulk vector fields and becomes quasilocalized. The masses of KK modes comprising the four-dimensional graviton are naturally exponentially small. This allows to push the Lorentz breaking scale to as high as a few tenth of the Planck mass. The model does not contain ghosts or tachyons and does not exhibit the van Dam-Veltman-Zakharov discontinuity. The gravitational attraction between static point masses becomes gradually weaker with increasing of separation and gets replaced by repulsion (antigravity) at exponentially large distances.

  2. Cosmological parameter estimation from CMB and X-ray cluster after Planck

    SciTech Connect

    Hu, Jian-Wei; Cai, Rong-Gen; Guo, Zong-Kuan; Hu, Bin E-mail: cairg@itp.ac.cn E-mail: hu@lorentz.leidenuniv.nl

    2014-05-01

    We investigate constraints on cosmological parameters in three 8-parameter models with the summed neutrino mass as a free parameter, by a joint analysis of CCCP X-ray cluster data, the newly released Planck CMB data as well as some external data sets including baryon acoustic oscillation measurements from the 6dFGS, SDSS DR7 and BOSS DR9 surveys, and Hubble Space Telescope H{sub 0} measurement. We find that the combined data strongly favor a non-zero neutrino masses at more than 3σ confidence level in these non-vanilla models. Allowing the CMB lensing amplitude A{sub L} to vary, we find A{sub L} > 1 at 3σ confidence level. For dark energy with a constant equation of state w, we obtain w < −1 at 3σ confidence level. The estimate of the matter power spectrum amplitude σ{sub 8} is discrepant with the Planck value at 2σ confidence level, which reflects some tension between X-ray cluster data and Planck data in these non-vanilla models. The tension can be alleviated by adding a 9% systematic shift in the cluster mass function.

  3. Cosmological parameter estimation from CMB and X-ray cluster after Planck

    NASA Astrophysics Data System (ADS)

    Hu, Jian-Wei; Cai, Rong-Gen; Guo, Zong-Kuan; Hu, Bin

    2014-05-01

    We investigate constraints on cosmological parameters in three 8-parameter models with the summed neutrino mass as a free parameter, by a joint analysis of CCCP X-ray cluster data, the newly released Planck CMB data as well as some external data sets including baryon acoustic oscillation measurements from the 6dFGS, SDSS DR7 and BOSS DR9 surveys, and Hubble Space Telescope H0 measurement. We find that the combined data strongly favor a non-zero neutrino masses at more than 3σ confidence level in these non-vanilla models. Allowing the CMB lensing amplitude AL to vary, we find AL > 1 at 3σ confidence level. For dark energy with a constant equation of state w, we obtain w < -1 at 3σ confidence level. The estimate of the matter power spectrum amplitude σ8 is discrepant with the Planck value at 2σ confidence level, which reflects some tension between X-ray cluster data and Planck data in these non-vanilla models. The tension can be alleviated by adding a 9% systematic shift in the cluster mass function.

  4. Treatment of 2,4-D, mecoprop, and dicamba using membrane bioreactor technology.

    PubMed

    Ghoshdastidar, Avik J; Tong, Anthony Z

    2013-08-01

    Phenoxyacetic and benzoic acid herbicides are widely used agricultural, commercial, and domestic pesticides. As a result of high water solubility, mobility, and persistence, 2,4-dichlorophenoxyacetic acid (2,4-D), methylchlorophenoxypropionic acid (mecoprop), and 3,6-dichloro-2-methoxybenzoic acid (dicamba) have been detected in surface and waste waters across Canada. As current municipal wastewater treatment plants do not specifically address chronic, trace levels of contaminants like pesticides, an urgent need exists for an efficient, environmentally friendly means of breaking down these toxic herbicides. A commercially available herbicide mix, WeedEx, containing 2,4-D, mecoprop, and dicamba, was subjected to treatment using membrane bioreactor (MBR) technology. The three herbicides, in simulated wastewater with a chemical oxygen demand of 745 mg/L, were introduced to the MBR at concentrations ranging from 300 μg/L to 3.5 mg/L. Herbicides and biodegradation products were extracted from MBR effluent using solid-phase extraction followed by detection using high-performance liquid chromatography coupled with mass spectrometry. 2,4-D was reduced by more than 99.0 % within 12 days. Mecoprop and dicamba were more persistent and reduced by 69.0 and 75.4 %, respectively, after 112 days of treatment. Half-lives of 2,4-D, mecoprop and dicamba during the treatment were determined to be 1.9, 10.5, and 28.3 days, respectively. Important water quality parameters of the effluent such as dissolved oxygen, pH, ammonia, chemical oxygen demand, etc. were measured daily. MBR was demonstrated to be an environmentally friendly, compact, and efficient method for the treatment of toxic phenoxyacetic and benzoic acid herbicides. PMID:23361178

  5. Inflationary paradigm in trouble after Planck2013

    NASA Astrophysics Data System (ADS)

    Ijjas, Anna; Steinhardt, Paul J.; Loeb, Abraham

    2013-06-01

    Recent results from the Planck satellite combined with earlier observations from WMAP, ACT, SPT and other experiments eliminate a wide spectrum of more complex inflationary models and favor models with a single scalar field, as reported by the Planck Collaboration. More important, though, is that all the simplest inflaton models are disfavored statistically relative to those with plateau-like potentials. We discuss how a restriction to plateau-like models has three independent serious drawbacks: it exacerbates both the initial conditions problem and the multiverse-unpredictability problem and it creates a new difficulty that we call the inflationary "unlikeliness problem." Finally, we comment on problems reconciling inflation with a standard model Higgs, as suggested by recent LHC results. In sum, we find that recent experimental data disfavors all the best-motivated inflationary scenarios and introduces new, serious difficulties that cut to the core of the inflationary paradigm. Forthcoming searches for B-modes, non-Gaussianity and new particles should be decisive.

  6. Astrophysical Data Transmission in Planck Units

    NASA Astrophysics Data System (ADS)

    Goradia, Shantilal

    2008-10-01

    ``Data Communication and Net Working'' by Forouzan expresses (an informatics equivalent of statistics) that N (data rate or bits/second) divided by r (number of data elements per signal or log2L) is the baud rate. For N = 10^43 Planck times per second, and L = 10^90, the number of photons in the universe, the baud rate is more than 10^40, so high a signal rate for the carriers of the attractive and repulsive pulses that we, the observers, would think that gravity is continuous, and not probabilistic. Any potential slight correction to the above as it may apply to the case, or its application to smaller baryon number (10^79) would not change the above implicit message, considering the order of magnitudes involved. This communicative aspect of gravity, and our postulation, slight modification to the inverse square law, in [1] that the probability of an interaction between two particles is inversely proportional to the square of their separations in integer number of Planck lengths, are mutually supplementary and complimentary, portraying two ducks that, not only walk like ducks, but also talk like ducks. Therefore, they are ducks. Refer to: [1] Goradia, Shantilal http://www.arXiv.org/pdf/physics/0210040v4.

  7. The best inflationary models after Planck

    SciTech Connect

    Martin, Jérôme; Vennin, Vincent; Ringeval, Christophe; Trotta, Roberto E-mail: christophe.ringeval@uclouvain.be E-mail: vennin@iap.fr

    2014-03-01

    We compute the Bayesian evidence and complexity of 193 slow-roll single-field models of inflation using the Planck 2013 Cosmic Microwave Background data, with the aim of establishing which models are favoured from a Bayesian perspective. Our calculations employ a new numerical pipeline interfacing an inflationary effective likelihood with the slow-roll library ASPIC and the nested sampling algorithm MultiNest. The models considered represent a complete and systematic scan of the entire landscape of inflationary scenarios proposed so far. Our analysis singles out the most probable models (from an Occam's razor point of view) that are compatible with Planck data, while ruling out with very strong evidence 34% of the models considered. We identify 26% of the models that are favoured by the Bayesian evidence, corresponding to 15 different potential shapes. If the Bayesian complexity is included in the analysis, only 9% of the models are preferred, corresponding to only 9 different potential shapes. These shapes are all of the plateau type.

  8. Mass of a Black Hole Firewall

    NASA Astrophysics Data System (ADS)

    Abramowicz, M. A.; Kluźniak, W.; Lasota, J.-P.

    2014-03-01

    Quantum entanglement of Hawking radiation has been supposed to give rise to a Planck density "firewall" near the event horizon of old black holes. We show that Planck density firewalls are excluded by Einstein's equations for black holes of mass exceeding the Planck mass. We find an upper limit of 1/(8πM) to the surface density of a firewall in a Schwarzschild black hole of mass M, translating for astrophysical black holes into a firewall density smaller than the Planck density by more than 30 orders of magnitude. A strict upper limit on the firewall density is given by the Planck density times the ratio MPl/(8πM).

  9. Mass of a black hole firewall.

    PubMed

    Abramowicz, M A; Kluźniak, W; Lasota, J-P

    2014-03-01

    Quantum entanglement of Hawking radiation has been supposed to give rise to a Planck density "firewall" near the event horizon of old black holes. We show that Planck density firewalls are excluded by Einstein's equations for black holes of mass exceeding the Planck mass. We find an upper limit of 1/(8πM) to the surface density of a firewall in a Schwarzschild black hole of mass M, translating for astrophysical black holes into a firewall density smaller than the Planck density by more than 30 orders of magnitude. A strict upper limit on the firewall density is given by the Planck density times the ratio M(Pl)/(8πM). PMID:24655237

  10. Mass of a black hole firewall.

    PubMed

    Abramowicz, M A; Kluźniak, W; Lasota, J-P

    2014-03-01

    Quantum entanglement of Hawking radiation has been supposed to give rise to a Planck density "firewall" near the event horizon of old black holes. We show that Planck density firewalls are excluded by Einstein's equations for black holes of mass exceeding the Planck mass. We find an upper limit of 1/(8πM) to the surface density of a firewall in a Schwarzschild black hole of mass M, translating for astrophysical black holes into a firewall density smaller than the Planck density by more than 30 orders of magnitude. A strict upper limit on the firewall density is given by the Planck density times the ratio M(Pl)/(8πM).

  11. 4D Proton treatment planning strategy for mobile lung tumors

    SciTech Connect

    Kang Yixiu; Zhang Xiaodong; Chang, Joe Y.; Wang He; Wei Xiong; Liao Zhongxing; Komaki, Ritsuko; Cox, James D.; Balter, Peter A.; Liu, Helen; Zhu, X. Ronald; Mohan, Radhe; Dong Lei . E-mail: ldong@mdanderson.org

    2007-03-01

    Purpose: To investigate strategies for designing compensator-based 3D proton treatment plans for mobile lung tumors using four-dimensional computed tomography (4DCT) images. Methods and Materials: Four-dimensional CT sets for 10 lung cancer patients were used in this study. The internal gross tumor volume (IGTV) was obtained by combining the tumor volumes at different phases of the respiratory cycle. For each patient, we evaluated four planning strategies based on the following dose calculations: (1) the average (AVE) CT; (2) the free-breathing (FB) CT; (3) the maximum intensity projection (MIP) CT; and (4) the AVE CT in which the CT voxel values inside the IGTV were replaced by a constant density (AVE{sub R}IGTV). For each strategy, the resulting cumulative dose distribution in a respiratory cycle was determined using a deformable image registration method. Results: There were dosimetric differences between the apparent dose distribution, calculated on a single CT dataset, and the motion-corrected 4D dose distribution, calculated by combining dose distributions delivered to each phase of the 4DCT. The AVE{sub R}IGTV plan using a 1-cm smearing parameter had the best overall target coverage and critical structure sparing. The MIP plan approach resulted in an unnecessarily large treatment volume. The AVE and FB plans using 1-cm smearing did not provide adequate 4D target coverage in all patients. By using a larger smearing value, adequate 4D target coverage could be achieved; however, critical organ doses were increased. Conclusion: The AVE{sub R}IGTV approach is an effective strategy for designing proton treatment plans for mobile lung tumors.

  12. Localization of 4D gravity on pure geometrical thick branes

    SciTech Connect

    Barbosa-Cendejas, Nandinii; Herrera-Aguilar, Alfredo

    2006-04-15

    We consider the generation of thick brane configurations in a pure geometric Weyl integrable 5D spacetime which constitutes a non-Riemannian generalization of Kaluza-Klein (KK) theory. In this framework, we show how 4D gravity can be localized on a scalar thick brane which does not necessarily respect reflection symmetry, generalizing in this way several previous models based on the Randall-Sundrum (RS) system and avoiding both, the restriction to orbifold geometries and the introduction of the branes in the action by hand. We first obtain a thick brane solution that preserves 4D Poincare invariance and breaks Z{sub 2}-symmetry along the extra dimension which, indeed, can be either compact or extended, and supplements brane solutions previously found by other authors. In the noncompact case, this field configuration represents a thick brane with positive energy density centered at y=c{sub 2}, whereas pairs of thick branes arise in the compact case. Remarkably, the Weylian scalar curvature is nonsingular along the fifth dimension in the noncompact case, in contraposition to the RS thin brane system. We also recast the wave equations of the transverse traceless modes of the linear fluctuations of the classical background into a Schroedinger's equation form with a volcano potential of finite bottom in both the compact and the extended cases. We solve Schroedinger equation for the massless zero mode m{sup 2}=0 and obtain a single bound wave function which represents a stable 4D graviton. We also get a continuum gapless spectrum of KK states with m{sup 2}>0 that are suppressed at y=c{sub 2} and turn asymptotically into plane waves.

  13. Phase and amplitude binning for 4D-CT imaging

    NASA Astrophysics Data System (ADS)

    Abdelnour, A. F.; Nehmeh, S. A.; Pan, T.; Humm, J. L.; Vernon, P.; Schöder, H.; Rosenzweig, K. E.; Mageras, G. S.; Yorke, E.; Larson, S. M.; Erdi, Y. E.

    2007-07-01

    We compare the consistency and accuracy of two image binning approaches used in 4D-CT imaging. One approach, phase binning (PB), assigns each breathing cycle 2π rad, within which the images are grouped. In amplitude binning (AB), the images are assigned bins according to the breathing signal's full amplitude. To quantitate both approaches we used a NEMA NU2-2001 IEC phantom oscillating in the axial direction and at random frequencies and amplitudes, approximately simulating a patient's breathing. 4D-CT images were obtained using a four-slice GE Lightspeed CT scanner operating in cine mode. We define consistency error as a measure of ability to correctly bin over repeated cycles in the same field of view. Average consistency error μe ± σe in PB ranged from 18% ± 20% to 30% ± 35%, while in AB the error ranged from 11% ± 14% to 20% ± 24%. In PB nearly all bins contained sphere slices. AB was more accurate, revealing empty bins where no sphere slices existed. As a proof of principle, we present examples of two non-small cell lung carcinoma patients' 4D-CT lung images binned by both approaches. While AB can lead to gaps in the coronal images, depending on the patient's breathing pattern, PB exhibits no gaps but suffers visible artifacts due to misbinning, yielding images that cover a relatively large amplitude range. AB was more consistent, though often resulted in gaps when no data existed due to patients' breathing pattern. We conclude AB is more accurate than PB. This has important consequences to treatment planning and diagnosis.

  14. Non-spherical particle generation from 4D optofluidic fabrication.

    PubMed

    Paulsen, Kevin S; Chung, Aram J

    2016-08-01

    Particles with non-spherical shapes can exhibit properties which are not available from spherical shaped particles. Complex shaped particles can provide unique benefits for areas such as drug delivery, tissue engineering, structural materials, and self-assembly building blocks. Current methods of creating complex shaped particles such as 3D printing, photolithography, and imprint lithography are limited by either slow speeds, shape limitations, or expensive processes. Previously, we presented a novel microfluidic flow lithography fabrication scheme combined with fluid inertia called optofluidic fabrication for the creation of complex shaped three-dimensional (3D) particles. This process was able to address the aforementioned limits and overcome two-dimensional shape limitations faced by traditional flow lithography methods; however, all of the created 3D particle shapes displayed top-down symmetry. Here, by introducing the time dimension into our existing optofluidic fabrication process, we break this top-down symmetry, generating fully asymmetric 3D particles where we termed the process: four-dimensional (4D) optofluidic fabrication. This 4D optofluidic fabrication is comprised of three sequential procedures. First, density mismatched precursor fluids flow past pillars within fluidic channels to manipulate the flow cross sections via fluid inertia. Next, the time dimension is incorporated by stopping the flow and allowing the denser fluids to settle by gravity to create asymmetric flow cross sections. Finally, the fluids are exposed to patterned ultraviolet (UV) light in order to polymerize fully asymmetric 3D-shaped particles. By varying inertial flow shaping, gravity-induced flow shaping, and UV light patterns, 4D optofluidic fabrication can create an infinite set of complex shaped asymmetric particles. PMID:27092661

  15. Non-spherical particle generation from 4D optofluidic fabrication.

    PubMed

    Paulsen, Kevin S; Chung, Aram J

    2016-08-01

    Particles with non-spherical shapes can exhibit properties which are not available from spherical shaped particles. Complex shaped particles can provide unique benefits for areas such as drug delivery, tissue engineering, structural materials, and self-assembly building blocks. Current methods of creating complex shaped particles such as 3D printing, photolithography, and imprint lithography are limited by either slow speeds, shape limitations, or expensive processes. Previously, we presented a novel microfluidic flow lithography fabrication scheme combined with fluid inertia called optofluidic fabrication for the creation of complex shaped three-dimensional (3D) particles. This process was able to address the aforementioned limits and overcome two-dimensional shape limitations faced by traditional flow lithography methods; however, all of the created 3D particle shapes displayed top-down symmetry. Here, by introducing the time dimension into our existing optofluidic fabrication process, we break this top-down symmetry, generating fully asymmetric 3D particles where we termed the process: four-dimensional (4D) optofluidic fabrication. This 4D optofluidic fabrication is comprised of three sequential procedures. First, density mismatched precursor fluids flow past pillars within fluidic channels to manipulate the flow cross sections via fluid inertia. Next, the time dimension is incorporated by stopping the flow and allowing the denser fluids to settle by gravity to create asymmetric flow cross sections. Finally, the fluids are exposed to patterned ultraviolet (UV) light in order to polymerize fully asymmetric 3D-shaped particles. By varying inertial flow shaping, gravity-induced flow shaping, and UV light patterns, 4D optofluidic fabrication can create an infinite set of complex shaped asymmetric particles.

  16. Founding Gravitation in 4D Euclidean Space-Time Geometry

    SciTech Connect

    Winkler, Franz-Guenter

    2010-11-24

    The Euclidean interpretation of special relativity which has been suggested by the author is a formulation of special relativity in ordinary 4D Euclidean space-time geometry. The natural and geometrically intuitive generalization of this view involves variations of the speed of light (depending on location and direction) and a Euclidean principle of general covariance. In this article, a gravitation model by Jan Broekaert, which implements a view of relativity theory in the spirit of Lorentz and Poincare, is reconstructed and shown to fulfill the principles of the Euclidean approach after an appropriate reinterpretation.

  17. CMT4D (NDRG1 mutation): genotype-phenotype correlations.

    PubMed

    Ricard, Emilie; Mathis, Stéphane; Magdelaine, Corinne; Delisle, Marie-Bernadette; Magy, Laurent; Funalot, Benoît; Vallat, Jean-Michel

    2013-09-01

    Charcot-Marie-Tooth (CMT) disease is a heterogeneous condition with a large number of clinical, electrophysiological and pathological phenotypes. More than 40 genes are involved. We report a child of gypsy origin with an autosomal recessive demyelinating phenotype. Clinical data, familial history, and electrophysiological studies were in favor of a CMT4 sub-type. The characteristic N-Myc downstream-regulated gene 1 (NDRG1) mutation responsible for this CMT4D phenotype was confirmed: p.R148X. The exact molecular function of the NDRG1 protein has yet to be elucidated.

  18. Multicolor 4D Fluorescence Microscopy using Ultrathin Bessel Light Sheets.

    PubMed

    Zhao, Teng; Lau, Sze Cheung; Wang, Ying; Su, Yumian; Wang, Hao; Cheng, Aifang; Herrup, Karl; Ip, Nancy Y; Du, Shengwang; Loy, M M T

    2016-01-01

    We demonstrate a simple and efficient method for producing ultrathin Bessel ('non-diffracting') light sheets of any color using a line-shaped beam and an annulus filter. With this robust and cost-effective technology, we obtained two-color, 3D images of biological samples with lateral/axial resolution of 250 nm/400 nm, and high-speed, 4D volume imaging of 20 μm sized live sample at 1 Hz temporal resolution. PMID:27189786

  19. Oblique sounding using the DPS-4D stations in Europe

    NASA Astrophysics Data System (ADS)

    Mosna, Zbysek; Kouba, Daniel; Koucka Knizova, Petra; Arikan, Feza; Arikan, Orhan; Gok, Gokhan; Rejfek, Lubos

    2016-07-01

    The DPS-4D Digisondes are capable of detection of echoes from neighbouring European stations. Currently, a campaign with high-temporal resolution of 5 min is being run. Further, ionograms from regular vertical sounding with 15 min resolution provide us with oblique reflections together with vertical reflections. We analyzed profiles of electron concentration and basic ionospheric parameters derived from the ionograms. We compared results derived from reflections from the ionosphere above the stations (vertical sounding) with information derived from oblique reflections between the stations. This study is supported by the Joint TUBITAK 114E092 and AS CR 14/001 projects.

  20. Lagrangian constraints and renormalization of 4D gravity

    NASA Astrophysics Data System (ADS)

    Park, I. Y.

    2015-04-01

    It has been proposed in [21] that 4D Einstein gravity becomes effectively reduced to 3D after solving the Lagrangian analogues of the Hamiltonian and momentum constraints of the Hamiltonian quantization. The analysis in [21] was carried out at the classical/operator level. We review the proposal and make a transition to the path integral account. We then set the stage for explicitly carrying out the two-loop renormalization procedure of the resulting 3D action. We also address a potentially subtle issue in the gravity context concerning whether renormalizability does not depend on the background around which the original action is expanded.

  1. Multicolor 4D Fluorescence Microscopy using Ultrathin Bessel Light Sheets

    PubMed Central

    Zhao, Teng; Lau, Sze Cheung; Wang, Ying; Su, Yumian; Wang, Hao; Cheng, Aifang; Herrup, Karl; Ip, Nancy Y.; Du, Shengwang; Loy, M. M. T.

    2016-01-01

    We demonstrate a simple and efficient method for producing ultrathin Bessel (‘non-diffracting’) light sheets of any color using a line-shaped beam and an annulus filter. With this robust and cost-effective technology, we obtained two-color, 3D images of biological samples with lateral/axial resolution of 250 nm/400 nm, and high-speed, 4D volume imaging of 20 μm sized live sample at 1 Hz temporal resolution. PMID:27189786

  2. All the supersymmetric configurations of N=4, d=4 supergravity

    NASA Astrophysics Data System (ADS)

    Bellorín, Jorge; Ortín, Tomás

    2005-10-01

    All the supersymmetric configurations of pure, ungauged, N=4, d=4 supergravity are classified in a formalism that keeps manifest the S and T dualities of the theory. We also find simple equations that need to be satisfied by the configurations to be classical solutions of the theory. While the solutions associated to null Killing vectors were essentially classified by Tod (a classification that we refine), we find new configurations and solutions associated to timelike Killing vectors that do not satisfy Tod's rigidity hypothesis (hence, they have a nontrivial U(1) connection) and whose supersymmetry projector is associated to 1-dimensional objects (strings), although they have a trivial axion field.

  3. Actively triggered 4d cone-beam CT acquisition

    SciTech Connect

    Fast, Martin F.; Wisotzky, Eric; Oelfke, Uwe; Nill, Simeon

    2013-09-15

    Purpose: 4d cone-beam computed tomography (CBCT) scans are usually reconstructed by extracting the motion information from the 2d projections or an external surrogate signal, and binning the individual projections into multiple respiratory phases. In this “after-the-fact” binning approach, however, projections are unevenly distributed over respiratory phases resulting in inefficient utilization of imaging dose. To avoid excess dose in certain respiratory phases, and poor image quality due to a lack of projections in others, the authors have developed a novel 4d CBCT acquisition framework which actively triggers 2d projections based on the forward-predicted position of the tumor.Methods: The forward-prediction of the tumor position was independently established using either (i) an electromagnetic (EM) tracking system based on implanted EM-transponders which act as a surrogate for the tumor position, or (ii) an external motion sensor measuring the chest-wall displacement and correlating this external motion to the phase-shifted diaphragm motion derived from the acquired images. In order to avoid EM-induced artifacts in the imaging detector, the authors devised a simple but effective “Faraday” shielding cage. The authors demonstrated the feasibility of their acquisition strategy by scanning an anthropomorphic lung phantom moving on 1d or 2d sinusoidal trajectories.Results: With both tumor position devices, the authors were able to acquire 4d CBCTs free of motion blurring. For scans based on the EM tracking system, reconstruction artifacts stemming from the presence of the EM-array and the EM-transponders were greatly reduced using newly developed correction algorithms. By tuning the imaging frequency independently for each respiratory phase prior to acquisition, it was possible to harmonize the number of projections over respiratory phases. Depending on the breathing period (3.5 or 5 s) and the gantry rotation time (4 or 5 min), between ∼90 and 145

  4. 4D micro-CT using fast prospective gating

    NASA Astrophysics Data System (ADS)

    Guo, Xiaolian; Johnston, Samuel M.; Qi, Yi; Johnson, G. Allan; Badea, Cristian T.

    2012-01-01

    Micro-CT is currently used in preclinical studies to provide anatomical information. But, there is also significant interest in using this technology to obtain functional information. We report here a new sampling strategy for 4D micro-CT for functional cardiac and pulmonary imaging. Rapid scanning of free-breathing mice is achieved with fast prospective gating (FPG) implemented on a field programmable gate array. The method entails on-the-fly computation of delays from the R peaks of the ECG signals or the peaks of the respiratory signals for the triggering pulses. Projection images are acquired for all cardiac or respiratory phases at each angle before rotating to the next angle. FPG can deliver the faster scan time of retrospective gating (RG) with the regular angular distribution of conventional prospective gating for cardiac or respiratory gating. Simultaneous cardio-respiratory gating is also possible with FPG in a hybrid retrospective/prospective approach. We have performed phantom experiments to validate the new sampling protocol and compared the results from FPG and RG in cardiac imaging of a mouse. Additionally, we have evaluated the utility of incorporating respiratory information in 4D cardiac micro-CT studies with FPG. A dual-source micro-CT system was used for image acquisition with pulsed x-ray exposures (80 kVp, 100 mA, 10 ms). The cardiac micro-CT protocol involves the use of a liposomal blood pool contrast agent containing 123 mg I ml-1 delivered via a tail vein catheter in a dose of 0.01 ml g-1 body weight. The phantom experiment demonstrates that FPG can distinguish the successive phases of phantom motion with minimal motion blur, and the animal study demonstrates that respiratory FPG can distinguish inspiration and expiration. 4D cardiac micro-CT imaging with FPG provides image quality superior to RG at an isotropic voxel size of 88 µm and 10 ms temporal resolution. The acquisition time for either sampling approach is less than 5 min. The

  5. Fokker-Planck/Transport model for neutral beam driven tokamaks

    SciTech Connect

    Killeen, J.; Mirin, A.A.; McCoy, M.G.

    1980-01-01

    The application of nonlinear Fokker-Planck models to the study of beam-driven plasmas is briefly reviewed. This evolution of models has led to a Fokker-Planck/Transport (FPT) model for neutral-beam-driven Tokamaks, which is described in detail. The FPT code has been applied to the PLT, PDX, and TFTR Tokamaks, and some representative results are presented.

  6. Evaluation of intrinsic respiratory signal determination methods for 4D CBCT adapted for mice

    SciTech Connect

    Martin, Rachael; Pan, Tinsu; Rubinstein, Ashley; Court, Laurence; Ahmad, Moiz

    2015-01-15

    Purpose: 4D CT imaging in mice is important in a variety of areas including studies of lung function and tumor motion. A necessary step in 4D imaging is obtaining a respiratory signal, which can be done through an external system or intrinsically through the projection images. A number of methods have been developed that can successfully determine the respiratory signal from cone-beam projection images of humans, however only a few have been utilized in a preclinical setting and most of these rely on step-and-shoot style imaging. The purpose of this work is to assess and make adaptions of several successful methods developed for humans for an image-guided preclinical radiation therapy system. Methods: Respiratory signals were determined from the projection images of free-breathing mice scanned on the X-RAD system using four methods: the so-called Amsterdam shroud method, a method based on the phase of the Fourier transform, a pixel intensity method, and a center of mass method. The Amsterdam shroud method was modified so the sharp inspiration peaks associated with anesthetized mouse breathing could be detected. Respiratory signals were used to sort projections into phase bins and 4D images were reconstructed. Error and standard deviation in the assignment of phase bins for the four methods compared to a manual method considered to be ground truth were calculated for a range of region of interest (ROI) sizes. Qualitative comparisons were additionally made between the 4D images obtained using each of the methods and the manual method. Results: 4D images were successfully created for all mice with each of the respiratory signal extraction methods. Only minimal qualitative differences were noted between each of the methods and the manual method. The average error (and standard deviation) in phase bin assignment was 0.24 ± 0.08 (0.49 ± 0.11) phase bins for the Fourier transform method, 0.09 ± 0.03 (0.31 ± 0.08) phase bins for the modified Amsterdam shroud method, 0

  7. Functional organization of the human 4D Nucleome

    PubMed Central

    Chen, Haiming; Chen, Jie; Muir, Lindsey A.; Ronquist, Scott; Meixner, Walter; Ljungman, Mats; Ried, Thomas; Smale, Stephen; Rajapakse, Indika

    2015-01-01

    The 4D organization of the interphase nucleus, or the 4D Nucleome (4DN), reflects a dynamical interaction between 3D genome structure and function and its relationship to phenotype. We present initial analyses of the human 4DN, capturing genome-wide structure using chromosome conformation capture and 3D imaging, and function using RNA-sequencing. We introduce a quantitative index that measures underlying topological stability of a genomic region. Our results show that structural features of genomic regions correlate with function with surprising persistence over time. Furthermore, constructing genome-wide gene-level contact maps aided in identifying gene pairs with high potential for coregulation and colocalization in a manner consistent with expression via transcription factories. We additionally use 2D phase planes to visualize patterns in 4DN data. Finally, we evaluated gene pairs within a circadian gene module using 3D imaging, and found periodicity in the movement of clock circadian regulator and period circadian clock 2 relative to each other that followed a circadian rhythm and entrained with their expression. PMID:26080430

  8. Atlas construction for dynamic (4D) PET using diffeomorphic transformations.

    PubMed

    Bieth, Marie; Lombaert, Hervé; Reader, Andrew J; Siddiqi, Kaleem

    2013-01-01

    A novel dynamic (4D) PET to PET image registration procedure is proposed and applied to multiple PET scans acquired with the high resolution research tomograph (HRRT), the highest resolution human brain PET scanner available in the world. By extending the recent diffeomorphic log-demons (DLD) method and applying it to multiple dynamic [11C]raclopride scans from the HRRT, an important step towards construction of a PET atlas of unprecedented quality for [11C]raclopride imaging of the human brain has been achieved. Accounting for the temporal dimension in PET data improves registration accuracy when compared to registration of 3D to 3D time-averaged PET images. The DLD approach was chosen for its ease in providing both an intensity and shape template, through iterative sequential pair-wise registrations with fast convergence. The proposed method is applicable to any PET radiotracer, providing 4D atlases with useful applications in high accuracy PET data simulations and automated PET image analysis. PMID:24579121

  9. 488-4D ASH LANDFILL CLOSURE CAP HELP MODELING

    SciTech Connect

    Phifer, M.

    2014-11-17

    At the request of Area Completion Projects (ACP) in support of the 488-4D Landfill closure, the Savannah River National Laboratory (SRNL) has performed Hydrologic Evaluation of Landfill Performance (HELP) modeling of the planned 488-4D Ash Landfill closure cap to ensure that the South Carolina Department of Health and Environmental Control (SCDHEC) limit of no more than 12 inches of head on top of the barrier layer (saturated hydraulic conductivity of no more than 1.0E-05 cm/s) in association with a 25-year, 24-hour storm event is not projected to be exceeded. Based upon Weber 1998 a 25-year, 24-hour storm event at the Savannah River Site (SRS) is 6.1 inches. The results of the HELP modeling indicate that the greatest peak daily head on top of the barrier layer (i.e. geosynthetic clay liner (GCL) or high density polyethylene (HDPE) geomembrane) for any of the runs made was 0.079 inches associated with a peak daily precipitation of 6.16 inches. This is well below the SCDHEC limit of 12 inches.

  10. 4D Dynamic Required Navigation Performance Final Report

    NASA Technical Reports Server (NTRS)

    Finkelsztein, Daniel M.; Sturdy, James L.; Alaverdi, Omeed; Hochwarth, Joachim K.

    2011-01-01

    New advanced four dimensional trajectory (4DT) procedures under consideration for the Next Generation Air Transportation System (NextGen) require an aircraft to precisely navigate relative to a moving reference such as another aircraft. Examples are Self-Separation for enroute operations and Interval Management for in-trail and merging operations. The current construct of Required Navigation Performance (RNP), defined for fixed-reference-frame navigation, is not sufficiently specified to be applicable to defining performance levels of such air-to-air procedures. An extension of RNP to air-to-air navigation would enable these advanced procedures to be implemented with a specified level of performance. The objective of this research effort was to propose new 4D Dynamic RNP constructs that account for the dynamic spatial and temporal nature of Interval Management and Self-Separation, develop mathematical models of the Dynamic RNP constructs, "Required Self-Separation Performance" and "Required Interval Management Performance," and to analyze the performance characteristics of these air-to-air procedures using the newly developed models. This final report summarizes the activities led by Raytheon, in collaboration with GE Aviation and SAIC, and presents the results from this research effort to expand the RNP concept to a dynamic 4D frame of reference.

  11. Complete valvular heart apparatus model from 4D cardiac CT.

    PubMed

    Grbic, Sasa; Ionasec, Razvan; Vitanovski, Dime; Voigt, Ingmar; Wang, Yang; Georgescu, Bogdan; Navab, Nassir; Comaniciu, Dorin

    2012-07-01

    The cardiac valvular apparatus, composed of the aortic, mitral, pulmonary and tricuspid valves, is an essential part of the anatomical, functional and hemodynamic characteristics of the heart and the cardiovascular system as a whole. Valvular heart diseases often involve multiple dysfunctions and require joint assessment and therapy of the valves. In this paper, we propose a complete and modular patient-specific model of the cardiac valvular apparatus estimated from 4D cardiac CT data. A new constrained Multi-linear Shape Model (cMSM), conditioned by anatomical measurements, is introduced to represent the complex spatio-temporal variation of the heart valves. The cMSM is exploited within a learning-based framework to efficiently estimate the patient-specific valve parameters from cine images. Experiments on 64 4D cardiac CT studies demonstrate the performance and clinical potential of the proposed method. Our method enables automatic quantitative evaluation of the complete valvular apparatus based on non-invasive imaging techniques. In conjunction with existent patient-specific chamber models, the presented valvular model enables personalized computation modeling and realistic simulation of the entire cardiac system.

  12. Composite Inflation in the light of 2015 Planck data

    NASA Astrophysics Data System (ADS)

    Channuie, Phongpichit

    2016-08-01

    In this work, we examine cosmological constraints on models of composite inflation based on the slow-roll approximation by using the recent Planck measurement. We compare the spectral index of curvature perturbation (and its running) and the tensor-to-scalar ratio predicted by such models with Planck 2015 data. We find that the predictions of technicolor inflation are nicely consistent with the Planck analysis. Moreover, the predictions from the second model, glueball inflation, are in good agreement with the Planck data at 2σC.L. However, the final two models, super glueball inflation and orientifold inflation, favor only the rather large value of the tensor-to-scalar ratio of which the predictions are in tension with the Planck analysis.

  13. The Planck Mission: Recent Results, Cosmological and Fundamental Physics Perspectives

    NASA Astrophysics Data System (ADS)

    Mandolesi, Nazzareno; Burigana, Carlo; Gruppuso, Alessandro; Natoli, Paolo

    2015-01-01

    We provide a description of the latest status and performance of the Planck satellite, focusing on the final predicted sensitivity of Planck. The optimization of the observational strategy for the additional surveys following the nominal fifteen months of integration (about two surveys) originally allocated and the limitation represented by astrophysical foreground emissions are presented. An outline of early and intermediate astrophysical results from the Planck Collaboration is provided. A concise view of some fundamental cosmological results that will be achieved by exploiting Planck's full set of temperature and polarization data is presented. Finally, the perspectives opened by Planck in answering some key questions in fundamental physics, with particular attention to Parity symmetry analyses, are described.

  14. Significant Redistribution of Ce 4d Oscillator Strength Observed in Photoionization of Endohedral Ce-C{sub 82}{sup +} Ions

    SciTech Connect

    Mueller, A.; Schippers, S.; Habibi, M.; Esteves, D.; Wang, J. C.; Phaneuf, R. A.; Kilcoyne, A. L. D.; Aguilar, A.; Dunsch, L.

    2008-09-26

    Mass-selected beams of atomic Ce{sup q+} ions (q=2, 3, 4), of C{sub 82}{sup +} and of endohedral Ce-C{sub 82}{sup +} ions were employed to study photoionization of free and encaged cerium atoms. The Ce 4d inner-shell contributions to single and double ionization of the endohedral Ce-C{sub 82}{sup +} fullerene have been extracted from the data and compared with expectations based on theory and the experiments with atomic Ce ions. Dramatic reduction and redistribution of the ionization contributions to 4d photoabsorption is observed. More than half of the Ce 4d oscillator strength appears to be diverted to the additional decay channels opened by the fullerene cage surrounding the Ce atom.

  15. Parametrized modified gravity constraints after Planck

    NASA Astrophysics Data System (ADS)

    Hu, Bin; Liguori, Michele; Bartolo, Nicola; Matarrese, Sabino

    2013-12-01

    We constrain f(R) and chameleon-type modified gravity in the framework of the Berstchinger-Zukin parametrization using the recently released Planck data, including both the cosmic mircowave background radiation (CMB) temperature power spectrum and the lensing potential power spectrum. Some other external data sets are included, such as baryon acoustic oscillation (BAO) measurements from the 6dFGS, SDSS DR7 and BOSS DR9 surveys; Hubble Space Telescope (HST) H0 measurements, and supernovae from the Union2.1 compilation. We also use WMAP9 data for a consistency check and comparison. For f(R) gravity, WMAP9 results can only give a quite loose constraint on the modified gravity parameter B0, which is related to the present value of the Compton wavelength of the extra scalar degree of freedom, B0<3.37 at 95% C.L. We demonstrate that this constraint mainly comes from the late integrated Sachs-Wolfe effect. With only Planck CMB temperature power-spectrum data, we can improve the WMAP9 result by a factor 3.7 (B0<0.91 at 95% C.L.). If the Planck lensing potential power-spectrum data are also taken into account, the constraint can be further strengthened by a factor 5.1 (B0<0.18 at 95% C.L.). This major improvement mainly comes from the small-scale lensing signal. Furthermore, BAO, HST and supernovae data could slightly improve the B0 bound (B0<0.12 at 95% C.L.). For the chameleon-type model, we find that the data set that we used cannot constrain the Compton wavelength B0 or the potential index s of the chameleon field, but it can give a tight constraint on the parameter β1=1.043-0.104+0.163 at 95% C.L. (β1=1 in general relativity), which accounts for the nonminimal coupling between the chameleon field and the matter component. In addition, we find that both modified gravity models we consider favor a relatively higher Hubble parameter than the concordance ΛCDM model in general relativity.

  16. Constraints on secret neutrino interactions after Planck

    NASA Astrophysics Data System (ADS)

    Forastieri, Francesco; Lattanzi, Massimiliano; Natoli, Paolo

    2015-07-01

    Neutrino interactions beyond the standard model of particle physics may affect the cosmological evolution and can be constrained through observations. We consider the possibility that neutrinos possess secret scalar or pseudoscalar interactions mediated by the Nambu-Goldstone boson of a still unknown spontaneously broken global U(1) symmetry, as in, e.g., Majoron models. In such scenarios, neutrinos still decouple at Tsimeq 1 MeV, but become tightly coupled again (``recouple'') at later stages of the cosmological evolution. We use available observations of the cosmic microwave background (CMB) anisotropies, including Planck 2013 and the joint BICEP2/Planck 2015 data, to derive constraints on the quantity γνν4, parameterizing the neutrino collision rate due to scalar or pseudoscalar interactions. We consider both a minimal extension of the standard ΛCDM model, and more complicated scenarios with extra relativistic degrees of freedom or non-vanishing tensor amplitude. For a wide range of dataset and model combinations, we find a typical constraint γνν4 lesssim 0.9× 10-27 (95% C.L.), implying an upper limit on the redshift zνrec of neutrino recoupling 0lesssim 850, leaving open the possibility that the latter occured well before hydrogen recombination. In the framework of Majoron models, the upper limit on γνν roughly translates on a constraint g lesssim 8.2× 10-7 on the Majoron-neutrino coupling constant g. In general, the data show a weak (~ 1σ) but intriguing preference for non-zero values of γνν4, with best fits in the range γνν4 = (0.15-0.35)× 10-27, depending on the particular dataset. This is more evident when either high-resolution CMB observations from the ACT and SPT experiments are included, or the possibility of non-vanishing tensor modes is considered. In particular, for the minimal model ΛCDM+γνν and including the Planck 2013, ACT and SPT data, we report γνν4=(0.44+0.17-0.36)×10-27 (0300 lesssim zνrec lesssim 550) at 68

  17. Physical properties of Galactic Planck cold cores revealed by the Hi-GAL survey

    NASA Astrophysics Data System (ADS)

    Zahorecz, S.; Jimenez-Serra, I.; Wang, K.; Testi, L.; Tóth, L. V.; Molinari, S.

    2016-06-01

    Context. Previous studies of the initial conditions of massive star and star cluster formation have mainly targeted infrared-dark clouds (or IRDCs) toward the inner Galaxy. This is because IRDCs were first detected in absorption against the bright mid-infrared (IR) background of the inner Galaxy, requiring a favorable location to be observed. By selection, IRDCs therefore represent only a fraction of the Galactic clouds capable of forming massive stars and star clusters. Owing their low dust temperatures, however, IRDCs are bright in the far-IR and millimeter and, thus, observations at these wavelengths have the potential to provide a complete sample of star-forming massive clouds across the Galaxy. Aims: Our aim is to identify the clouds at the initial conditions of massive star and star cluster formation across the Galaxy and compare their physical properties as a function of Galactic longitude and Galactocentric distance. Methods: We have examined the physical properties of a homogeneous Galactic cold core sample obtained with the Planck satellite across the Galactic plane. With the use of Herschel Hi-GAL observations, we characterized the internal structure of the most reliable Galactic cold clumps within the Early Cold Core (ECC) Planck catalog. By using background-subtracted Herschel images, we derived the H2 column density and dust temperature maps for 48 Planck clumps covered by the Herschel Hi-GAL survey. We calculated and analyzed the basic physical parameters (size, mass, and average dust temperature) of these clumps as a function of location within the Galaxy. We also compared these properties with the empirical relation for massive star formation previously derived. Results: Most of the Planck clumps contain signs of star formation. About 25% of the clumps are massive enough to form high-mass stars and star clusters since they exceed the empirical threshold for massive star formation. Planck clumps toward the Galactic center region show higher peak

  18. Planck intermediate results. XVIII. The millimetre and sub-millimetre emission from planetary nebulae

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Arnaud, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Battaner, E.; Benabed, K.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Buemi, C. S.; Burigana, C.; Cardoso, J.-F.; Casassus, S.; Catalano, A.; Cerrigone, L.; Chamballu, A.; Chiang, H. C.; Colombi, S.; Colombo, L. P. L.; Couchot, F.; Crill, B. P.; Curto, A.; Cuttaia, F.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Dickinson, C.; Diego, J. M.; Donzelli, S.; Doré, O.; Dupac, X.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Frailis, M.; Franceschi, E.; Galeotta, S.; Ganga, K.; Giard, M.; González-Nuevo, J.; Górski, K. M.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Harrison, D. L.; Hildebrandt, S. R.; Hivon, E.; Holmes, W. A.; Hora, J. L.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lawrence, C. R.; Leonardi, R.; Leto, P.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Macías-Pérez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Martin, P. G.; Masi, S.; Massardi, M.; Matarrese, S.; Mazzotta, P.; Mendes, L.; Mennella, A.; Migliaccio, M.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Noviello, F.; Novikov, D.; Novikov, I.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Peel, M.; Perdereau, O.; Perrotta, F.; Piacentini, F.; Piat, M.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Procopio, P.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reinecke, M.; Remazeilles, M.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Savini, G.; Scott, D.; Spencer, L. D.; Stolyarov, V.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Trigilio, C.; Tristram, M.; Trombetti, T.; Tucci, M.; Umana, G.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Zacchei, A.; Zijlstra, A.; Zonca, A.

    2015-01-01

    Late stages of stellar evolution are characterized by copious mass-loss events whose signature is the formation of circumstellar envelopes (CSE). Planck multi-frequency measurements have provided relevant information on a sample of Galactic planetary nebulae (PNe) in the important and relatively unexplored observational band between 30 and 857 GHz. Planck enables the assembly of comprehensive PNe spectral energy distributions (SEDs) from radio to far-IR frequencies. Modelling the derived SEDs provides us with information on physical properties of CSEs and the mass content of both main components: ionized gas, traced by the free-free emission at cm-mm waves; and thermal dust, traced by the millimetre and far-IR emission. In particular, the amount of ionized gas and dust has been derived here. Such quantities have also been estimated for the very young PN CRL 618, where the strong variability observed in its radio and millimetre emission has previously prevented constructing its SED. A morphological study of the Helix Nebula was also performed. Planck maps reveal, for the first time, the spatial distribution of the dust inside the envelope, allowing us to identify different components, the most interesting of which is a very extended component (up to 1 pc) that may be related to a region where the slow expanding envelope is interacting with the surrounding interstellar medium.

  19. CARMA FOLLOW-UP OF THE NORTHERN UNCONFIRMED PLANCK GALAXY CLUSTER CANDIDATES

    SciTech Connect

    Muchovej, Stephen; Leitch, Erik; Culverhouse, Thomas; Carpenter, John; Sievers, Jonathan

    2012-04-10

    We present the Combined Array for Research in Millimeter-wave Astronomy (CARMA) observations of the three northern unconfirmed galaxy clusters discovered by the Planck satellite. We confirm the existence of two massive clusters (PLCKESZ G115.71+17.52 and PLCKESZ G121.11+57.01) at high significance. For these clusters, we present refined centroid locations from the 31 GHz CARMA data, as well as mass estimates obtained from a joint analysis of CARMA and Planck data. We do not detect the third candidate, PLCKESZ G189.84-37.24, and place an upper limit on its mass of M{sub 500} < 3.2 Multiplication-Sign 10{sup 14} M{sub Sun} at 68% confidence. Considering our data and the characteristics of the Planck Early Sunyaev-Zel'dovich (ESZ) Catalog, we conclude that this object is likely to be a cold-core object in the plane of our Galaxy. As a result, we estimate the purity of the ESZ Catalog to be greater than 99.5%.

  20. The bandmerged Planck Early Release Compact Source Catalogue: probing sub-structure in the molecular gas at high Galactic latitude

    NASA Astrophysics Data System (ADS)

    Chen, X.; Chary, R.; Pearson, T. J.; McGehee, P.; Fowler, J. W.; Helou, G.

    2016-06-01

    The Planck Early Release Compact Source Catalogue (ERCSC) includes nine lists of highly reliable sources, individually extracted at each of the nine Planck frequency channels. To facilitate the study of the Planck sources, especially their spectral behaviour across the radio/infrared frequencies, we provide a `bandmerged' catalogue of the ERCSC sources. This catalogue consists of 15 191 entries, with 79 sources detected in all nine frequency channels of Planck and 6818 sources detected in only one channel. We describe the bandmerging algorithm, including the various steps used to disentangle sources in confused regions. The multifrequency matching allows us to develop spectral energy distributions of sources between 30 and 857 GHz, in particular across the 100 GHz band, where the energetically important CO J = 1→0 line enters the Planck bandpass. We find ˜3σ-5σ evidence for contribution to the 100 GHz intensity from foreground CO along the line of sight to 147 sources with |b|>{30°}. The median excess contribution is 4.5 ± 0.9 per cent of their measured 100 GHz flux density which cannot be explained by calibration or beam uncertainties. This translates to 0.5 ± 0.1 K km s-1 of CO which must be clumped on the scale of the Planck 100 GHz beam, i.e. ˜10 arcmin. If this is due to a population of low-mass (˜15 M⊙) molecular gas clumps, the total mass in these clumps may be more than 2000 M⊙. Further, high-spatial-resolution, ground-based observations of the high-latitude sky will help shed light on the origin of this diffuse, clumpy CO emission.

  1. Unveiling the most massive Planck clusters at z>0.5 (XMM LP re-observations).

    NASA Astrophysics Data System (ADS)

    Arnaud, Monique

    2012-10-01

    We have been awarded a Large Program in AO11 to gather spatially resolved X ray spectroscopy on a sample of 32 massive (M_500 > 5e+14Msun) clusters detected blindly by Planck in the redshift range 0.5mass, high-redshift regime, our aim is to study the fundamental scalings between YSZ, YX and M500, and the pressure and entropy profiles. This will provide an important probe of the physics of cluster gravitational collapse and be of large legacy value for the cosmological exploitation of the Planck sample. We propose to re-observe 8 targets, the observations of which are dramatically affected by flares.

  2. Planck-scale corrections to Friedmann equation

    NASA Astrophysics Data System (ADS)

    Awad, Adel; Ali, Ahmed

    2014-04-01

    Recently, Verlinde proposed that gravity is an emergent phenomenon which originates from an entropic force. In this work, we extend Verlinde's proposal to accommodate generalized uncertainty principles (GUP), which are suggested by some approaches to quantum gravity such as string theory, black hole physics and doubly special relativity (DSR). Using Verlinde's proposal and two known models of GUPs, we obtain modifications to Newton's law of gravitation as well as the Friedmann equation. Our modification to the Friedmann equation includes higher powers of the Hubble parameter which is used to obtain a corresponding Raychaudhuri equation. Solving this equation, we obtain a leading Planck-scale correction to Friedmann-Robertson-Walker (FRW) solutions for the p = ωp equation of state.

  3. 4D XCAT phantom for multimodality imaging research

    SciTech Connect

    Segars, W. P.; Sturgeon, G.; Mendonca, S.; Grimes, Jason; Tsui, B. M. W.

    2010-09-15

    Purpose: The authors develop the 4D extended cardiac-torso (XCAT) phantom for multimodality imaging research. Methods: Highly detailed whole-body anatomies for the adult male and female were defined in the XCAT using nonuniform rational B-spline (NURBS) and subdivision surfaces based on segmentation of the Visible Male and Female anatomical datasets from the National Library of Medicine as well as patient datasets. Using the flexibility of these surfaces, the Visible Human anatomies were transformed to match body measurements and organ volumes for a 50th percentile (height and weight) male and female. The desired body measurements for the models were obtained using the PEOPLESIZE program that contains anthropometric dimensions categorized from 1st to the 99th percentile for US adults. The desired organ volumes were determined from ICRP Publication 89 [ICRP, ''Basic anatomical and physiological data for use in radiological protection: reference values,'' ICRP Publication 89 (International Commission on Radiological Protection, New York, NY, 2002)]. The male and female anatomies serve as standard templates upon which anatomical variations may be modeled in the XCAT through user-defined parameters. Parametrized models for the cardiac and respiratory motions were also incorporated into the XCAT based on high-resolution cardiac- and respiratory-gated multislice CT data. To demonstrate the usefulness of the phantom, the authors show example simulation studies in PET, SPECT, and CT using publicly available simulation packages. Results: As demonstrated in the pilot studies, the 4D XCAT (which includes thousands of anatomical structures) can produce realistic imaging data when combined with accurate models of the imaging process. With the flexibility of the NURBS surface primitives, any number of different anatomies, cardiac or respiratory motions or patterns, and spatial resolutions can be simulated to perform imaging research. Conclusions: With the ability to produce

  4. 4D Light Field Imaging System Using Programmable Aperture

    NASA Technical Reports Server (NTRS)

    Bae, Youngsam

    2012-01-01

    Complete depth information can be extracted from analyzing all angles of light rays emanated from a source. However, this angular information is lost in a typical 2D imaging system. In order to record this information, a standard stereo imaging system uses two cameras to obtain information from two view angles. Sometimes, more cameras are used to obtain information from more angles. However, a 4D light field imaging technique can achieve this multiple-camera effect through a single-lens camera. Two methods are available for this: one using a microlens array, and the other using a moving aperture. The moving-aperture method can obtain more complete stereo information. The existing literature suggests a modified liquid crystal panel [LC (liquid crystal) panel, similar to ones commonly used in the display industry] to achieve a moving aperture. However, LC panels cannot withstand harsh environments and are not qualified for spaceflight. In this regard, different hardware is proposed for the moving aperture. A digital micromirror device (DMD) will replace the liquid crystal. This will be qualified for harsh environments for the 4D light field imaging. This will enable an imager to record near-complete stereo information. The approach to building a proof-ofconcept is using existing, or slightly modified, off-the-shelf components. An SLR (single-lens reflex) lens system, which typically has a large aperture for fast imaging, will be modified. The lens system will be arranged so that DMD can be integrated. The shape of aperture will be programmed for single-viewpoint imaging, multiple-viewpoint imaging, and coded aperture imaging. The novelty lies in using a DMD instead of a LC panel to move the apertures for 4D light field imaging. The DMD uses reflecting mirrors, so any light transmission lost (which would be expected from the LC panel) will be minimal. Also, the MEMS-based DMD can withstand higher temperature and pressure fluctuation than a LC panel can. Robotics need

  5. 4D XCAT phantom for multimodality imaging research

    PubMed Central

    Segars, W. P.; Sturgeon, G.; Mendonca, S.; Grimes, Jason; Tsui, B. M. W.

    2010-01-01

    Purpose: The authors develop the 4D extended cardiac-torso (XCAT) phantom for multimodality imaging research. Methods: Highly detailed whole-body anatomies for the adult male and female were defined in the XCAT using nonuniform rational B-spline (NURBS) and subdivision surfaces based on segmentation of the Visible Male and Female anatomical datasets from the National Library of Medicine as well as patient datasets. Using the flexibility of these surfaces, the Visible Human anatomies were transformed to match body measurements and organ volumes for a 50th percentile (height and weight) male and female. The desired body measurements for the models were obtained using the PEOPLESIZE program that contains anthropometric dimensions categorized from 1st to the 99th percentile for US adults. The desired organ volumes were determined from ICRP Publication 89 [ICRP, ‘‘Basic anatomical and physiological data for use in radiological protection: reference values,” ICRP Publication 89 (International Commission on Radiological Protection, New York, NY, 2002)]. The male and female anatomies serve as standard templates upon which anatomical variations may be modeled in the XCAT through user-defined parameters. Parametrized models for the cardiac and respiratory motions were also incorporated into the XCAT based on high-resolution cardiac- and respiratory-gated multislice CT data. To demonstrate the usefulness of the phantom, the authors show example simulation studies in PET, SPECT, and CT using publicly available simulation packages. Results: As demonstrated in the pilot studies, the 4D XCAT (which includes thousands of anatomical structures) can produce realistic imaging data when combined with accurate models of the imaging process. With the flexibility of the NURBS surface primitives, any number of different anatomies, cardiac or respiratory motions or patterns, and spatial resolutions can be simulated to perform imaging research. Conclusions: With the ability to produce

  6. Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications

    PubMed Central

    Yoshida, Yuji; Kang, Sujin; Ebina, Kousuke; Shi, Kenrin; Nojima, Satoshi; Kimura, Tetsuya; Ito, Daisuke; Morimoto, Keiko; Nishide, Masayuki; Hosokawa, Takashi; Hirano, Toru; Shima, Yoshihito; Narazaki, Masashi; Tsuboi, Hideki; Saeki, Yukihiko; Tomita, Tetsuya; Tanaka, Toshio; Kumanogoh, Atsushi

    2015-01-01

    Objective Semaphorin 4D (Sema4D)/CD100 has pleiotropic roles in immune activation, angiogenesis, bone metabolism, and neural development. We undertook this study to investigate the role of Sema4D in rheumatoid arthritis (RA). Methods Soluble Sema4D (sSema4D) levels in serum and synovial fluid were analyzed by enzyme‐linked immunosorbent assay. Cell surface expression and transcripts of Sema4D were analyzed in peripheral blood cells from RA patients, and immunohistochemical staining of Sema4D was performed in RA synovium. Generation of sSema4D was evaluated in an ADAMTS‐4–treated monocytic cell line (THP‐1 cells). The efficacy of anti‐Sema4D antibody was evaluated in mice with collagen‐induced arthritis (CIA). Results Levels of sSema4D were elevated in both serum and synovial fluid from RA patients, and disease activity markers were correlated with serum sSema4D levels. Sema4D‐expressing cells also accumulated in RA synovium. Cell surface levels of Sema4D on CD3+ and CD14+ cells from RA patients were reduced, although levels of Sema4D transcripts were unchanged. In addition, ADAMTS‐4 cleaved cell surface Sema4D to generate sSema4D in THP‐1 cells. Soluble Sema4D induced tumor necrosis factor α (TNFα) and interleukin‐6 (IL‐6) production from CD14+ monocytes. IL‐6 and TNFα induced ADAMTS‐4 expression in synovial cells. Treatment with an anti‐Sema4D antibody suppressed arthritis and reduced proinflammatory cytokine production in CIA. Conclusion A positive feedback loop involving sSema4D/IL‐6 and TNFα/ADAMTS‐4 may contribute to the pathogenesis of RA. The inhibition of arthritis by anti‐Sema4D antibody suggests that Sema4D represents a potential therapeutic target for RA. PMID:25707877

  7. Orthogonal non-Gaussianity in DBI galileon: prospect for Planck polarization and post-Planck experiments

    NASA Astrophysics Data System (ADS)

    Koyama, Kazuya; Pettinari, Guido Walter; Mizuno, Shuntaro; Fidler, Christian

    2014-06-01

    In this paper, we study cosmic microwave background (CMB) constraints on primordial non-Gaussianity in Dirac-Born-Infeld (DBI) galileon models in which an induced gravity term is added to the DBI action. In this model, the non-Gaussianity of orthogonal shape can be generated. We provide a relation between theoretical parameters and orthogonal/equilateral nonlinear parameters using the Fisher matrix approach for the CMB bispectrum. In doing so, we include the effect of the CMB transfer functions and experimental noise properties by employing the recently developed second order non-Gaussianity code. The relation is also shown in the language of effective theory so that it can be applied to general single-field models. Using the bispectrum Fisher matrix and the central values for equilateral and orthogonal non-Gaussianities found by the Planck temperature survey, we provide forecasts on the theoretical parameters of the DBI galileon model. We consider the upcoming Planck polarization data and the proposed post-Planck experiments Cosmic Origins Explore (COrE) and Polarized Radiation Imaging and Spectroscopy Mission (PRISM). We find that Planck polarization measurements may provide a hint for a non-canonical sound speed at the 68% confidence level. COrE and PRISM will not only confirm a non-canonical sound speed but also exclude the conventional DBI inflation model at more than the 95% and 99% confidence level respectively, assuming that the central values will not change. This indicates that improving constraints on non-Gaussianity further by future CMB experiments is invaluable to constrain the physics of the early universe.

  8. Mapping motion from 4D-MRI to 3D-CT for use in 4D dose calculations: A technical feasibility study

    SciTech Connect

    Boye, Dirk; Lomax, Tony; Knopf, Antje

    2013-06-15

    Purpose: Target sites affected by organ motion require a time resolved (4D) dose calculation. Typical 4D dose calculations use 4D-CT as a basis. Unfortunately, 4D-CT images have the disadvantage of being a 'snap-shot' of the motion during acquisition and of assuming regularity of breathing. In addition, 4D-CT acquisitions involve a substantial additional dose burden to the patient making many, repeated 4D-CT acquisitions undesirable. Here the authors test the feasibility of an alternative approach to generate patient specific 4D-CT data sets. Methods: In this approach motion information is extracted from 4D-MRI. Simulated 4D-CT data sets [which the authors call 4D-CT(MRI)] are created by warping extracted deformation fields to a static 3D-CT data set. The employment of 4D-MRI sequences for this has the advantage that no assumptions on breathing regularity are made, irregularities in breathing can be studied and, if necessary, many repeat imaging studies (and consequently simulated 4D-CT data sets) can be performed on patients and/or volunteers. The accuracy of 4D-CT(MRI)s has been validated by 4D proton dose calculations. Our 4D dose algorithm takes into account displacements as well as deformations on the originating 4D-CT/4D-CT(MRI) by calculating the dose of each pencil beam based on an individual time stamp of when that pencil beam is applied. According to corresponding displacement and density-variation-maps the position and the water equivalent range of the dose grid points is adjusted at each time instance. Results: 4D dose distributions, using 4D-CT(MRI) data sets as input were compared to results based on a reference conventional 4D-CT data set capturing similar motion characteristics. Almost identical 4D dose distributions could be achieved, even though scanned proton beams are very sensitive to small differences in the patient geometry. In addition, 4D dose calculations have been performed on the same patient, but using 4D-CT(MRI) data sets based on

  9. Planck 2015 results. XXVI. The Second Planck Catalogue of Compact Sources

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Argüeso, F.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Battaner, E.; Beichman, C.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Böhringer, H.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Carvalho, P.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chiang, H. C.; Christensen, P. R.; Clemens, M.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Falgarone, E.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leahy, J. P.; Leonardi, R.; León-Tavares, J.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Negrello, M.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Sanghera, H. S.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tornikoski, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Türler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Walter, B.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    The Second Planck Catalogue of Compact Sources is a list of discrete objects detected in single-frequency maps from the full duration of the Planck mission and supersedes previous versions. It consists of compact sources, both Galactic and extragalactic, detected over the entire sky. Compact sources detected in the lower frequency channels are assigned to the PCCS2, while at higher frequencies they are assigned to one of two subcatalogues, the PCCS2 or PCCS2E, depending on their location on the sky. The first of these (PCCS2) covers most of the sky and allows the user to produce subsamples at higher reliabilities than the target 80% integral reliability of the catalogue. The second (PCCS2E) contains sources detected in sky regions where the diffuse emission makes it difficult to quantify the reliability of the detections. Both the PCCS2 and PCCS2E include polarization measurements, in the form of polarized flux densities, or upper limits, and orientation angles for all seven polarization-sensitive Planck channels. The improved data-processing of the full-mission maps and their reduced noise levels allow us to increase the number of objects in the catalogue, improving its completeness for the target 80% reliability as compared with the previous versions, the PCCS and the Early Release Compact Source Catalogue (ERCSC).

  10. Biomechanics of DNA structures visualized by 4D electron microscopy

    PubMed Central

    Lorenz, Ulrich J.; Zewail, Ahmed H.

    2013-01-01

    We present a technique for in situ visualization of the biomechanics of DNA structural networks using 4D electron microscopy. Vibrational oscillations of the DNA structure are excited mechanically through a short burst of substrate vibrations triggered by a laser pulse. Subsequently, the motion is probed with electron pulses to observe the impulse response of the specimen in space and time. From the frequency and amplitude of the observed oscillations, we determine the normal modes and eigenfrequencies of the structures involved. Moreover, by selective “nano-cutting” at a given point in the network, it was possible to obtain Young’s modulus, and hence the stiffness, of the DNA filament at that position. This experimental approach enables nanoscale mechanics studies of macromolecules and should find applications in other domains of biological networks such as origamis. PMID:23382239

  11. Myocardial motion and function assessment using 4D images

    NASA Astrophysics Data System (ADS)

    Shi, Peng-Cheng; Robinson, Glynn P.; Duncan, James S.

    1994-09-01

    This paper describes efforts aimed at more objectively and accurately quantifying the local, regional and global function of the left ventricle (LV) of the heart from 4D image data. Using our shape-based image analysis methods, point-wise myocardial motion vector fields between successive image frames through the entire cardiac cycle will be computed. Quantitative LV motion, thickening, and strain measurements will then be established from the point correspondence maps. In the paper, we will also briefly describe an in vivo experimental model which uses implanted imaging-opaque markers to validate the results of our image analysis methods. Finally, initial experimental results using image sequences from two different modalities will be presented.

  12. Chaos in a 4D dissipative nonlinear fermionic model

    NASA Astrophysics Data System (ADS)

    Aydogmus, Fatma

    2015-12-01

    Gursey Model is the only possible 4D conformally invariant pure fermionic model with a nonlinear self-coupled spinor term. It has been assumed to be similar to the Heisenberg's nonlinear generalization of Dirac's equation, as a possible basis for a unitary description of elementary particles. Gursey Model admits particle-like solutions for the derived classical field equations and these solutions are instantonic in character. In this paper, the dynamical nature of damped and forced Gursey Nonlinear Differential Equations System (GNDES) are studied in order to get more information on spinor type instantons. Bifurcation and chaos in the system are observed by constructing the bifurcation diagrams and Poincaré sections. Lyapunov exponent and power spectrum graphs of GNDES are also constructed to characterize the chaotic behavior.

  13. Parallel Wavefront Analysis for a 4D Interferometer

    NASA Technical Reports Server (NTRS)

    Rao, Shanti R.

    2011-01-01

    This software provides a programming interface for automating data collection with a PhaseCam interferometer from 4D Technology, and distributing the image-processing algorithm across a cluster of general-purpose computers. Multiple instances of 4Sight (4D Technology s proprietary software) run on a networked cluster of computers. Each connects to a single server (the controller) and waits for instructions. The controller directs the interferometer to several images, then assigns each image to a different computer for processing. When the image processing is finished, the server directs one of the computers to collate and combine the processed images, saving the resulting measurement in a file on a disk. The available software captures approximately 100 images and analyzes them immediately. This software separates the capture and analysis processes, so that analysis can be done at a different time and faster by running the algorithm in parallel across several processors. The PhaseCam family of interferometers can measure an optical system in milliseconds, but it takes many seconds to process the data so that it is usable. In characterizing an adaptive optics system, like the next generation of astronomical observatories, thousands of measurements are required, and the processing time quickly becomes excessive. A programming interface distributes data processing for a PhaseCam interferometer across a Windows computing cluster. A scriptable controller program coordinates data acquisition from the interferometer, storage on networked hard disks, and parallel processing. Idle time of the interferometer is minimized. This architecture is implemented in Python and JavaScript, and may be altered to fit a customer s needs.

  14. History and progress on accurate measurements of the Planck constant.

    PubMed

    Steiner, Richard

    2013-01-01

    The measurement of the Planck constant, h, is entering a new phase. The CODATA 2010 recommended value is 6.626 069 57 × 10(-34) J s, but it has been a long road, and the trip is not over yet. Since its discovery as a fundamental physical constant to explain various effects in quantum theory, h has become especially important in defining standards for electrical measurements and soon, for mass determination. Measuring h in the International System of Units (SI) started as experimental attempts merely to prove its existence. Many decades passed while newer experiments measured physical effects that were the influence of h combined with other physical constants: elementary charge, e, and the Avogadro constant, N(A). As experimental techniques improved, the precision of the value of h expanded. When the Josephson and quantum Hall theories led to new electronic devices, and a hundred year old experiment, the absolute ampere, was altered into a watt balance, h not only became vital in definitions for the volt and ohm units, but suddenly it could be measured directly and even more accurately. Finally, as measurement uncertainties now approach a few parts in 10(8) from the watt balance experiments and Avogadro determinations, its importance has been linked to a proposed redefinition of a kilogram unit of mass. The path to higher accuracy in measuring the value of h was not always an example of continuous progress. Since new measurements periodically led to changes in its accepted value and the corresponding SI units, it is helpful to see why there were bumps in the road and where the different branch lines of research joined in the effort. Recalling the bumps along this road will hopefully avoid their repetition in the upcoming SI redefinition debates. This paper begins with a brief history of the methods to measure a combination of fundamental constants, thus indirectly obtaining the Planck constant. The historical path is followed in the section describing how the

  15. Planck early results. XXII. The submillimetre properties of a sample of Galactic cold clumps

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Balbi, A.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Benoît, A.; Bernard, J.-P.; Bersanelli, M.; Bhatia, R.; Bock, J. J.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Cabella, P.; Cantalupo, C. M.; Cardoso, J.-F.; Catalano, A.; Cayón, L.; Challinor, A.; Chamballu, A.; Chiang, L.-Y.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Couchot, F.; Coulais, A.; Crill, B. P.; Cuttaia, F.; Danese, L.; Davies, R. D.; de Bernardis, P.; de Gasperis, G.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Dickinson, C.; Doi, Y.; Donzelli, S.; Doré, O.; Dörl, U.; Douspis, M.; Dupac, X.; Efstathiou, G.; Enßlin, T. A.; Falgarone, E.; Finelli, F.; Forni, O.; Frailis, M.; Franceschi, E.; Galeotta, S.; Ganga, K.; Giard, M.; Giardino, G.; Giraud-Héraud, Y.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Harrison, D.; Helou, G.; Henrot-Versillé, S.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hovest, W.; Hoyland, R. J.; Huffenberger, K. M.; Ikeda, N.; Jaffe, A. H.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kitamura, Y.; Kneissl, R.; Knox, L.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Laureijs, R. J.; Lawrence, C. R.; Leach, S.; Leonardi, R.; Leroy, C.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; MacTavish, C. J.; Maffei, B.; Malinen, J.; Mandolesi, N.; Mann, R.; Maris, M.; Marshall, D. J.; Martin, P.; Martínez-González, E.; Masi, S.; Matarrese, S.; Matthai, F.; Mazzotta, P.; McGehee, P.; Melchiorri, A.; Mendes, L.; Mennella, A.; Meny, C.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Osborne, S.; Pagani, L.; Pajot, F.; Paladini, R.; Pasian, F.; Patanchon, G.; Pelkonen, V.-M.; Perdereau, O.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Poutanen, T.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savini, G.; Scott, D.; Seiffert, M. D.; Smoot, G. F.; Starck, J.-L.; Stivoli, F.; Stolyarov, V.; Sudiwala, R.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Torre, J.-P.; Toth, V.; Tristram, M.; Tuovinen, J.; Umana, G.; Valenziano, L.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; Ysard, N.; Yvon, D.; Zacchei, A.; Zonca, A.

    2011-12-01

    We perform a detailed investigation of sources from the Cold Cores Catalogue of Planck Objects (C3PO). Our goal is to probe the reliability of the detections, validate the separation between warm and cold dust emission components, provide the first glimpse at the nature, internal morphology and physical characterictics of the Planck-detected sources. We focus on a sub-sample of ten sources from the C3PO list, selected to sample different environments, from high latitude cirrus to nearby (150pc) and remote (2kpc) molecular complexes. We present Planck surface brightness maps and derive the dust temperature, emissivity spectral index, and column densities of the fields. With the help of higher resolution Herschel and AKARI continuum observations and molecular line data, we investigate the morphology of the sources and the properties of the substructures at scales below the Planck beam size. The cold clumps detected by Planck are found to be located on large-scale filamentary (or cometary) structures that extend up to 20pc in the remote sources. The thickness of these filaments ranges between 0.3 and 3pc, for column densities NH2 ~ 0.1 to 1.6 × 1022 cm-2, and with linear mass density covering a broad range, between 15 and 400 M⊙ pc-1. The dust temperatures are low (between 10 and 15K) and the Planck cold clumps correspond to local minima of the line-of-sight averaged dust temperature in these fields. These low temperatures are confirmed when AKARI and Herschel data are added to the spectral energy distributions. Herschel data reveal a wealth of substructure within the Planck cold clumps. In all cases (except two sources harbouring young stellar objects), the substructures are found to be colder, with temperatures as low as 7K. Molecular line observations provide gas column densities which are consistent with those inferred from the dust. The linewidths are all supra-thermal, providing large virial linear mass densities in the range 10 to 300 M⊙ pc-1, comparable

  16. Escape from a Crisis in Fokker-Planck Models

    NASA Astrophysics Data System (ADS)

    Portegies Zwart, Simon F.; Takahashi, Koji

    1999-01-01

    Recent N-body simulations have shown that there is a serious discrepancy between the results of N-body simulations and the results of Fokker-Planck simulations for the evolution of globular and rich open clusters under the influence of the galactic tidal field. In some cases, the lifetime obtained from Fokker-Planck calculations is more than an order of magnitude smaller than those from N-body simulations. In this paper we show that the principal cause for this discrepancy is an over-simplified treatment of the tidal field used in previous Fokker-Planck simulations. We performed new Fokker-Planck calculations using a more appropriate implementation for the boundary condition of the tidal field. The implementation is only possible with anisotropic Fokker-Planck models, while all previous Fokker-Planck calculations rely on the assumption of isotropy. Our new Fokker-Planck results agree well with N-body results. Comparison of the two types of simulations gives a better understanding of the evolution of such clusters.

  17. Detection of thermal SZ-CMB lensing cross-correlation in Planck nominal mission data

    SciTech Connect

    Hill, J. Colin; Spergel, David N. E-mail: dns@astro.princeton.edu

    2014-02-01

    The nominal mission maps from the Planck satellite contain a wealth of information about secondary anisotropies in the cosmic microwave background (CMB), including those induced by the thermal Sunyaev-Zel'dovich (tSZ) effect and gravitational lensing. As both the tSZ and CMB lensing signals trace the large-scale matter density field, the anisotropies sourced by these processes are expected to be correlated. We report the first detection of this cross-correlation signal, which we measure at 6.2σ significance using the Planck data. We take advantage of Planck's multifrequency coverage to construct a tSZ map using internal linear combination techniques, which we subsequently cross-correlate with the publicly-released Planck CMB lensing potential map. The cross-correlation is subject to contamination from the cosmic infrared background (CIB), which is known to correlate strongly with CMB lensing. We correct for this contamination via cross-correlating our tSZ map with the Planck 857 GHz map and confirm the robustness of our measurement using several null tests. We interpret the signal using halo model calculations, which indicate that the tSZ-CMB lensing cross-correlation is a unique probe of the physics of intracluster gas in high-redshift, low-mass groups and clusters. Our results are consistent with extrapolations of existing gas physics models to this previously unexplored regime and show clear evidence for contributions from both the one- and two-halo terms, but no statistically significant evidence for contributions from diffuse, unbound gas outside of collapsed halos. We also show that the amplitude of the signal depends rather sensitively on the amplitude of fluctuations (σ{sub 8}) and the matter density (Ω{sub m}), scaling as σ{sub 8}{sup 6.1}Ω{sub m}{sup 1.5} at ℓ = 1000. We constrain the degenerate combination σ{sub 8}(Ω{sub m}/0.282){sup 0.26} = 0.824±0.029, a result that is in less tension with primordial CMB constraints than some recent t

  18. Max Planck and the ``black year'' of German physics

    NASA Astrophysics Data System (ADS)

    Mulligan, Joseph F.

    1994-12-01

    1994 is the hundredth anniversary of what Max Planck described in 1935 as the ``black year'' of German physics. In the eight months between January 1st and September 8th 1894, Heinrich Hertz, August Kundt, and Hermann von Helmholtz died. This article reviews the lives of these three important physicists, their research contributions, and their unique positions in the German physics community. In conclusion, the relationships of these three physicists to Planck are discussed, and Planck's evaluation of the impact of 1894 on physics in Germany is appraised from our perspective of one hundred years.

  19. Respiratory triggered 4D cone-beam computed tomography: A novel method to reduce imaging dose

    PubMed Central

    Cooper, Benjamin J.; O’Brien, Ricky T.; Balik, Salim; Hugo, Geoffrey D.; Keall, Paul J.

    2013-01-01

    Purpose: A novel method called respiratory triggered 4D cone-beam computed tomography (RT 4D CBCT) is described whereby imaging dose can be reduced without degrading image quality. RT 4D CBCT utilizes a respiratory signal to trigger projections such that only a single projection is assigned to a given respiratory bin for each breathing cycle. In contrast, commercial 4D CBCT does not actively use the respiratory signal to minimize image dose. Methods: To compare RT 4D CBCT with conventional 4D CBCT, 3600 CBCT projections of a thorax phantom were gathered and reconstructed to generate a ground truth CBCT dataset. Simulation pairs of conventional 4D CBCT acquisitions and RT 4D CBCT acquisitions were developed assuming a sinusoidal respiratory signal which governs the selection of projections from the pool of 3600 original projections. The RT 4D CBCT acquisition triggers a single projection when the respiratory signal enters a desired acquisition bin; the conventional acquisition does not use a respiratory trigger and projections are acquired at a constant frequency. Acquisition parameters studied were breathing period, acquisition time, and imager frequency. The performance of RT 4D CBCT using phase based and displacement based sorting was also studied. Image quality was quantified by calculating difference images of the test dataset from the ground truth dataset. Imaging dose was calculated by counting projections. Results: Using phase based sorting RT 4D CBCT results in 47% less imaging dose on average compared to conventional 4D CBCT. Image quality differences were less than 4% at worst. Using displacement based sorting RT 4D CBCT results in 57% less imaging dose on average, than conventional 4D CBCT methods; however, image quality was 26% worse with RT 4D CBCT. Conclusions: Simulation studies have shown that RT 4D CBCT reduces imaging dose while maintaining comparable image quality for phase based 4D CBCT; image quality is degraded for displacement based RT 4D

  20. A technique for estimating 4D-CBCT using prior knowledge and limited-angle projections

    SciTech Connect

    Zhang, You; Yin, Fang-Fang; Ren, Lei; Segars, W. Paul

    2013-12-15

    Purpose: To develop a technique to estimate onboard 4D-CBCT using prior information and limited-angle projections for potential 4D target verification of lung radiotherapy.Methods: Each phase of onboard 4D-CBCT is considered as a deformation from one selected phase (prior volume) of the planning 4D-CT. The deformation field maps (DFMs) are solved using a motion modeling and free-form deformation (MM-FD) technique. In the MM-FD technique, the DFMs are estimated using a motion model which is extracted from planning 4D-CT based on principal component analysis (PCA). The motion model parameters are optimized by matching the digitally reconstructed radiographs of the deformed volumes to the limited-angle onboard projections (data fidelity constraint). Afterward, the estimated DFMs are fine-tuned using a FD model based on data fidelity constraint and deformation energy minimization. The 4D digital extended-cardiac-torso phantom was used to evaluate the MM-FD technique. A lung patient with a 30 mm diameter lesion was simulated with various anatomical and respirational changes from planning 4D-CT to onboard volume, including changes of respiration amplitude, lesion size and lesion average-position, and phase shift between lesion and body respiratory cycle. The lesions were contoured in both the estimated and “ground-truth” onboard 4D-CBCT for comparison. 3D volume percentage-difference (VPD) and center-of-mass shift (COMS) were calculated to evaluate the estimation accuracy of three techniques: MM-FD, MM-only, and FD-only. Different onboard projection acquisition scenarios and projection noise levels were simulated to investigate their effects on the estimation accuracy.Results: For all simulated patient and projection acquisition scenarios, the mean VPD (±S.D.)/COMS (±S.D.) between lesions in prior images and “ground-truth” onboard images were 136.11% (±42.76%)/15.5 mm (±3.9 mm). Using orthogonal-view 15°-each scan angle, the mean VPD/COMS between the lesion

  1. Parallel Infrastructure Modeling and Inversion Module for E4D

    SciTech Connect

    2014-10-09

    Electrical resistivity tomography ERT is a method of imaging the electrical conductivity of the subsurface. Electrical conductivity is a useful metric for understanding the subsurface because it is governed by geomechanical and geochemical properties that drive subsurface systems. ERT works by injecting current into the subsurface across a pair of electrodes, and measuring the corresponding electrical potential response across another pair of electrodes. Many such measurements are strategically taken across an array of electrodes to produce an ERT data set. These data are then processed through a computationally demanding process known as inversion to produce an image of the subsurface conductivity structure that gave rise to the measurements. Data can be inverted to provide 2D images, 3D images, or in the case of time-lapse 3D imaging, 4D images. ERT is generally not well suited for environments with buried electrically conductive infrastructure such as pipes, tanks, or well casings, because these features tend to dominate and degrade ERT images. This reduces or eliminates the utility of ERT imaging where it would otherwise be highly useful for, for example, imaging fluid migration from leaking pipes, imaging soil contamination beneath leaking subusurface tanks, and monitoring contaminant migration in locations with dense network of metal cased monitoring wells. The location and dimension of buried metallic infrastructure is often known. If so, then the effects of the infrastructure can be explicitly modeled within the ERT imaging algorithm, and thereby removed from the corresponding ERT image. However,there are a number of obstacles limiting this application. 1) Metallic infrastructure cannot be accurately modeled with standard codes because of the large contrast in conductivity between the metal and host material. 2) Modeling infrastructure in true dimension requires the computational mesh to be highly refined near the metal inclusions, which increases

  2. 4D Dynamic RNP Annual Interim Report-Year 1

    NASA Technical Reports Server (NTRS)

    Finkelsztein, Daniel M.; Sturdy, James L.; Alaverdi, Omeed; Chung, William W.; Salvano, Daniel; Klooster, Joel; Hochwarth, Joachim K.

    2010-01-01

    This Annual Interim Report summarizes the activities led by Raytheon, in collaboration with GE Aviation and SAIC, and presents the results obtained during the first year of this research effort to expand the RNP concept to 4 dimensions relative to a dynamic frame of reference. Joint Program Development Office (JPDO)Concepts of Operations for the Next Generation Air Transportation System (NextGen) considers 4 Dimension Trajectory (4DT) procedures a key enabler to Trajectory Based Operations (TBO). The JPDO defines 4DT as a precise description of an aircraft path in space and time . While NextGen assumes that this path is defined within an Earth-reference frame, many 4DT procedure implementations will require an aircraft to precisely navigate relative to a moving reference such as another aircraft to form aggregate flows or a weather cell to allow for flows to shift. Current methods of implementing routes and flight paths rely on aircraft meeting a Required Navigation Performance (RNP) specification and being equipped with a monitoring and alerting capability to annunciate when the aircraft system is unable to meet the performance specification required for the operation. Since all aircraft today operate within the NAS relative to fixed reference points, the current RNP definition is deemed satisfactory. However, it is not well understood how the current RNP construct will support NextGen 4DT procedures where aircraft operate relative to each other or to other dynamic frames of reference. The objective of this research effort is to analyze candidate 4DT procedures from both an Air Navigation Service Provider (ANSP) and aircraft perspective, to identify their specific navigational requirements, assess the shortcomings of the current RNP construct to meet these requirements, to propose an extended 4 Dimensional Dynamic RNP (4D Dynamic RNP) construct that accounts for the dynamic spatial and temporal nature of the selected 4DT procedures, and finally, to design an

  3. Properties of interstellar filaments derived from Herschel, Planck, and molecular line observations

    NASA Astrophysics Data System (ADS)

    Arzoumanian, Doris

    2015-08-01

    The highly filamentary structure of the interstellar medium (ISM) is now impressively revealed by Herschel and Planck images. Previous observations have shown that clouds are filamentary, however, only recently the mapping capabilities of Herscheland Planck have discovered their ubiquity in the ISM. In particular, Herschel images, with their high spatial and intensity dynamic ranges, show that dense filaments are associated with the main sites of star formation, demonstrating their key role in the star formation process.The analysis of the column density profiles of filaments indicates that they all share a common central width of 0.1pc, while they span a wide range in length, column density, mass per unit length. The results derived from observations tracing cold dust and gas emission, in total and polarised intensity, suggest that filaments can be divided into two families: On the one hand, low column density, unbound, and quiescent filaments mostly aligned with the magnetic field orientation, and on the other hand, dense, self-gravitating filaments, which fragment into star forming cores.I will present the properties of the filamentary structures derived from Herschel, Planck, and molecular line observations, and I will discuss the observational constraints on the formation and evolution of interstellar filaments.

  4. Principal component analysis of the reionization history from Planck 2015 data

    NASA Astrophysics Data System (ADS)

    Dai, Wei-Ming; Guo, Zong-Kuan; Cai, Rong-Gen

    2015-12-01

    The simple assumption of an instantaneous reionization of the Universe may bias estimates of cosmological parameters. In this paper a model-independent principal component method for the reionization history is applied to give constraints on the cosmological parameters from recent Planck 2015 data. We find that the Universe is not completely reionized at redshifts z ≥8.5 at 95% C.L. Both the reionization optical depth and matter fluctuation amplitude are higher than but consistent with those obtained in the standard instantaneous reionization scheme. The high estimated value of the matter fluctuation amplitude strengthens the tension between Planck cosmic microwave background observations and some astrophysical data, such as cluster counts and weak lensing. The tension can be significantly relieved if the neutrino masses are allowed to vary. Thanks to a high scalar spectral index, the low-scale spontaneously broken supersymmetry inflationary model can fit the data well, which is marginally disfavored at 95% C.L. in the Planck analysis.

  5. Multimaterial 4D Printing with Tailorable Shape Memory Polymers.

    PubMed

    Ge, Qi; Sakhaei, Amir Hosein; Lee, Howon; Dunn, Conner K; Fang, Nicholas X; Dunn, Martin L

    2016-08-08

    We present a new 4D printing approach that can create high resolution (up to a few microns), multimaterial shape memory polymer (SMP) architectures. The approach is based on high resolution projection microstereolithography (PμSL) and uses a family of photo-curable methacrylate based copolymer networks. We designed the constituents and compositions to exhibit desired thermomechanical behavior (including rubbery modulus, glass transition temperature and failure strain which is more than 300% and larger than any existing printable materials) to enable controlled shape memory behavior. We used a high resolution, high contrast digital micro display to ensure high resolution of photo-curing methacrylate based SMPs that requires higher exposure energy than more common acrylate based polymers. An automated material exchange process enables the manufacture of 3D composite architectures from multiple photo-curable SMPs. In order to understand the behavior of the 3D composite microarchitectures, we carry out high fidelity computational simulations of their complex nonlinear, time-dependent behavior and study important design considerations including local deformation, shape fixity and free recovery rate. Simulations are in good agreement with experiments for a series of single and multimaterial components and can be used to facilitate the design of SMP 3D structures.

  6. Multimaterial 4D Printing with Tailorable Shape Memory Polymers

    NASA Astrophysics Data System (ADS)

    Ge, Qi; Sakhaei, Amir Hosein; Lee, Howon; Dunn, Conner K.; Fang, Nicholas X.; Dunn, Martin L.

    2016-08-01

    We present a new 4D printing approach that can create high resolution (up to a few microns), multimaterial shape memory polymer (SMP) architectures. The approach is based on high resolution projection microstereolithography (PμSL) and uses a family of photo-curable methacrylate based copolymer networks. We designed the constituents and compositions to exhibit desired thermomechanical behavior (including rubbery modulus, glass transition temperature and failure strain which is more than 300% and larger than any existing printable materials) to enable controlled shape memory behavior. We used a high resolution, high contrast digital micro display to ensure high resolution of photo-curing methacrylate based SMPs that requires higher exposure energy than more common acrylate based polymers. An automated material exchange process enables the manufacture of 3D composite architectures from multiple photo-curable SMPs. In order to understand the behavior of the 3D composite microarchitectures, we carry out high fidelity computational simulations of their complex nonlinear, time-dependent behavior and study important design considerations including local deformation, shape fixity and free recovery rate. Simulations are in good agreement with experiments for a series of single and multimaterial components and can be used to facilitate the design of SMP 3D structures.

  7. Multimaterial 4D Printing with Tailorable Shape Memory Polymers

    PubMed Central

    Ge, Qi; Sakhaei, Amir Hosein; Lee, Howon; Dunn, Conner K.; Fang, Nicholas X.; Dunn, Martin L.

    2016-01-01

    We present a new 4D printing approach that can create high resolution (up to a few microns), multimaterial shape memory polymer (SMP) architectures. The approach is based on high resolution projection microstereolithography (PμSL) and uses a family of photo-curable methacrylate based copolymer networks. We designed the constituents and compositions to exhibit desired thermomechanical behavior (including rubbery modulus, glass transition temperature and failure strain which is more than 300% and larger than any existing printable materials) to enable controlled shape memory behavior. We used a high resolution, high contrast digital micro display to ensure high resolution of photo-curing methacrylate based SMPs that requires higher exposure energy than more common acrylate based polymers. An automated material exchange process enables the manufacture of 3D composite architectures from multiple photo-curable SMPs. In order to understand the behavior of the 3D composite microarchitectures, we carry out high fidelity computational simulations of their complex nonlinear, time-dependent behavior and study important design considerations including local deformation, shape fixity and free recovery rate. Simulations are in good agreement with experiments for a series of single and multimaterial components and can be used to facilitate the design of SMP 3D structures. PMID:27499417

  8. Effortless assignment with 4D covariance sequential correlation maps.

    PubMed

    Harden, Bradley J; Mishra, Subrata H; Frueh, Dominique P

    2015-11-01

    Traditional Nuclear Magnetic Resonance (NMR) assignment procedures for proteins rely on preliminary peak-picking to identify and label NMR signals. However, such an approach has severe limitations when signals are erroneously labeled or completely neglected. The consequences are especially grave for proteins with substantial peak overlap, and mistakes can often thwart entire projects. To overcome these limitations, we previously introduced an assignment technique that bypasses traditional pick peaking altogether. Covariance Sequential Correlation Maps (COSCOMs) transform the indirect connectivity information provided by multiple 3D backbone spectra into direct (H, N) to (H, N) correlations. Here, we present an updated method that utilizes a single four-dimensional spectrum rather than a suite of three-dimensional spectra. We demonstrate the advantages of 4D-COSCOMs relative to their 3D counterparts. We introduce improvements accelerating their calculation. We discuss practical considerations affecting their quality. And finally we showcase their utility in the context of a 52 kDa cyclization domain from a non-ribosomal peptide synthetase.

  9. Multimaterial 4D Printing with Tailorable Shape Memory Polymers.

    PubMed

    Ge, Qi; Sakhaei, Amir Hosein; Lee, Howon; Dunn, Conner K; Fang, Nicholas X; Dunn, Martin L

    2016-01-01

    We present a new 4D printing approach that can create high resolution (up to a few microns), multimaterial shape memory polymer (SMP) architectures. The approach is based on high resolution projection microstereolithography (PμSL) and uses a family of photo-curable methacrylate based copolymer networks. We designed the constituents and compositions to exhibit desired thermomechanical behavior (including rubbery modulus, glass transition temperature and failure strain which is more than 300% and larger than any existing printable materials) to enable controlled shape memory behavior. We used a high resolution, high contrast digital micro display to ensure high resolution of photo-curing methacrylate based SMPs that requires higher exposure energy than more common acrylate based polymers. An automated material exchange process enables the manufacture of 3D composite architectures from multiple photo-curable SMPs. In order to understand the behavior of the 3D composite microarchitectures, we carry out high fidelity computational simulations of their complex nonlinear, time-dependent behavior and study important design considerations including local deformation, shape fixity and free recovery rate. Simulations are in good agreement with experiments for a series of single and multimaterial components and can be used to facilitate the design of SMP 3D structures. PMID:27499417

  10. Effortless assignment with 4D covariance sequential correlation maps

    NASA Astrophysics Data System (ADS)

    Harden, Bradley J.; Mishra, Subrata H.; Frueh, Dominique P.

    2015-11-01

    Traditional Nuclear Magnetic Resonance (NMR) assignment procedures for proteins rely on preliminary peak-picking to identify and label NMR signals. However, such an approach has severe limitations when signals are erroneously labeled or completely neglected. The consequences are especially grave for proteins with substantial peak overlap, and mistakes can often thwart entire projects. To overcome these limitations, we previously introduced an assignment technique that bypasses traditional pick peaking altogether. Covariance Sequential Correlation Maps (COSCOMs) transform the indirect connectivity information provided by multiple 3D backbone spectra into direct (H, N) to (H, N) correlations. Here, we present an updated method that utilizes a single four-dimensional spectrum rather than a suite of three-dimensional spectra. We demonstrate the advantages of 4D-COSCOMs relative to their 3D counterparts. We introduce improvements accelerating their calculation. We discuss practical considerations affecting their quality. And finally we showcase their utility in the context of a 52 kDa cyclization domain from a non-ribosomal peptide synthetase.

  11. Digit ratio (2D:4D) and hand preference for writing in the BBC Internet Study.

    PubMed

    Manning, J T; Peters, M

    2009-09-01

    The ratio of the length of the second to the fourth digit (2D:4D) may be negatively correlated with prenatal testosterone. Hand preference has been linked with prenatal testosterone and 2D:4D. Here we show that 2D:4D is associated with hand preference for writing in a large internet sample (n>170,000) in which participants self-reported their finger lengths. We replicated a significant association between right 2D:4D and writing hand preference (low right 2D:4D associated with left hand preference) as well as a significant correlation between writing hand preference and the difference between left and right 2D:4D or Dr-l (low Dr-l associated with left hand preference). A new significant correlation between left 2D:4D and writing hand preference was also shown (high left 2D:4D associated with left hand preference). There was a clear interaction between writing hand preference and 2D:4D: The left 2D:4D was significantly larger than the right 2D:4D in male and female left-handed writers, and the right hand 2D:4D was significantly larger than the left hand 2D:4D in male and female right-handed writers.

  12. Fokker-Planck formalism in magnetic resonance simulations

    NASA Astrophysics Data System (ADS)

    Kuprov, Ilya

    2016-09-01

    This paper presents an overview of the Fokker-Planck formalism for non-biological magnetic resonance simulations, describes its existing applications and proposes some novel ones. The most attractive feature of Fokker-Planck theory compared to the commonly used Liouville - von Neumann equation is that, for all relevant types of spatial dynamics (spinning, diffusion, stationary flow, etc.), the corresponding Fokker-Planck Hamiltonian is time-independent. Many difficult NMR, EPR and MRI simulation problems (multiple rotation NMR, ultrafast NMR, gradient-based zero-quantum filters, diffusion and flow NMR, off-resonance soft microwave pulses in EPR, spin-spin coupling effects in MRI, etc.) are simplified significantly in Fokker-Planck space. The paper also summarises the author's experiences with writing and using the corresponding modules of the Spinach library - the methods described below have enabled a large variety of simulations previously considered too complicated for routine practical use.

  13. The Atacama Cosmology Telescope: cross correlation with Planck maps

    SciTech Connect

    Louis, Thibaut; Calabrese, Erminia; Dunkley, Joanna; Næss, Sigurd; Addison, Graeme E.; Hincks, Adam D.; Hasselfield, Matthew; Hlozek, Renée; Bond, J. Richard; Hajian, Amir; Das, Sudeep; Devlin, Mark J.; Dünner, Rolando; Infante, Leopoldo; Gralla, Megan; Marriage, Tobias A.; Huffenberger, Kevin; Kosowsky, Arthur; Moodley, Kavilan; Niemack, Michael D.; and others

    2014-07-01

    We present the temperature power spectrum of the Cosmic Microwave Background obtained by cross-correlating maps from the Atacama Cosmology Telescope (ACT) at 148 and 218 GHz with maps from the Planck satellite at 143 and 217 GHz, in two overlapping regions covering 592 square degrees. We find excellent agreement between the two datasets at both frequencies, quantified using the variance of the residuals between the ACT power spectra and the ACT × Planck cross-spectra. We use these cross-correlations to measure the calibration of the ACT data at 148 and 218 GHz relative to Planck, to 0.7% and 2% precision respectively. We find no evidence for anisotropy in the calibration parameter. We compare the Planck 353 GHz power spectrum with the measured amplitudes of dust and cosmic infrared background (CIB) of ACT data at 148 and 218 GHz. We also compare planet and point source measurements from the two experiments.

  14. Determining Planck's Constant Using a Light-emitting Diode.

    ERIC Educational Resources Information Center

    Sievers, Dennis; Wilson, Alan

    1989-01-01

    Describes a method for making a simple, inexpensive apparatus which can be used to determine Planck's constant. Provides illustrations of a circuit diagram using one or more light-emitting diodes and a BASIC computer program for simplifying calculations. (RT)

  15. Escape from a Crisis in Foller-Planck Models

    NASA Astrophysics Data System (ADS)

    Portegies Zwart, S.; Takahashi, K.

    Using direct N-body simulations which include both the evolution of single stars and the tidal field of the parent galaxy, the dynamical evolution of globular clusters and rich open clusters are studied. The simulations, performed on the GRAPE-4, employ up to 32,768 stars. Comparison of our results with isotropic Fokker-Planck calculations reveals a large discrepancy. The principal cause for the discrepancy is a too simplified treatment of the tidal truncation used in previous Fokker-Planck simulations. We performed new Fokker-Planck calculations using a more appropriate boundary condition for the tidal cutoff. The implementation of this condition requires anisotropic Fokker-Planck models. Our new results agree well with the N-body simulations. Comparison of the two types of simulations gives a better understanding of the cluster evolution, and clarifies why the results of N-body simulations did not seem scale with respect to N.

  16. Estimation of volcanic ash emissions from satellite data using trajectory-based 4D-Var

    NASA Astrophysics Data System (ADS)

    Lu, Sha; Lin, Haixiang; Heemink, Arnold; Segers, Arjo; Fu, Guangliang

    2016-04-01

    An accurate determination of emission parameters are crucial to the volcanic ash forecast for aviation, health and climate interests. In this study, we reconstruct the vertical profile of the volcanic ash emission from satellite ash mass loading data using trajectory-based 4D-Var (Trj4DVar) approach with Eyjafjallajökull 2010 eruptive event and the corresponding SEVIRI data as a study case. Since the Eyjafjallajökull eruption in April 2010, besides ash mass loadings retrieved from satellite data, the additional information of plume height and mass eruption rate is always available from volcanic ash detections and observations. Modifications is made in Trj4DVar to integrate the additional information into the data assimilation system to improve the estimation of volcanic ash emissions and achieve a better initial condition for quantitative predictions. The modified Trj4DVar has been tested in twin experiments designed based on the study case, and shows significant improvement on straightforward Trj4DVar since it has great correction impact to recognize the injection height and produce more accurate emission estimation and reliable initial field of volcanic ash loading. To apply the approach to the real case with SEVIRI data, two strategies was proposed: observational mask matrix and separate time windows. The results produced a better initial condition and predictive forecast that were more fitter the SEVIRI ash mass loading fields, which showed a great potential of applying the method in practice.

  17. Planck priors for dark energy surveys

    SciTech Connect

    Mukherjee, Pia; Parkinson, David; Kunz, Martin; Wang Yun

    2008-10-15

    Although cosmic microwave background anisotropy data alone cannot constrain simultaneously the spatial curvature and the equation of state of dark energy, CMB data provide a valuable addition to other experimental results. However computing a full CMB power spectrum with a Boltzmann code is quite slow; for instance if we want to work with many dark energy and/or modified gravity models, or would like to optimize experiments where many different configurations need to be tested, it is possible to adopt a quicker and more efficient approach. In this paper we consider the compression of the projected Planck cosmic microwave background data into four parameters, R (scaled distance to last scattering surface), l{sub a} (angular scale of sound horizon at last scattering), {omega}{sub b}h{sup 2} (baryon density fraction) and n{sub s} (powerlaw index of primordial matter power spectrum), all of which can be computed quickly. We show that, although this compression loses information compared to the full likelihood, such information loss becomes negligible when more data is added. We also demonstrate that the method can be used for canonical scalar-field dark energy independently of the parametrization of the equation of state, and discuss how this method should be used for other kinds of dark energy models.

  18. Detecting primordial B-modes after Planck

    NASA Astrophysics Data System (ADS)

    Creminelli, Paolo; López Nacir, Diana; Simonović, Marko; Trevisan, Gabriele; Zaldarriaga, Matias

    2015-11-01

    We update the forecasts for the measurement of the tensor-to-scalar ratio r for various ground-based experiments (AdvACT, CLASS, Keck/BICEP3, Simons Array, SPT-3G), balloons (EBEX 10k and Spider) and satellites (CMBPol, COrE and LiteBIRD), taking into account the recent Planck data on polarized dust and using a component separation method. The forecasts do not change significantly with respect to previous estimates when at least three frequencies are available, provided foregrounds can be accurately described by few parameters. We argue that a theoretically motivated goal for future experiments is r~2×10-3, and that this is achievable if the noise is reduced to ~1 μK-arcmin and lensing is reduced to 10% in power. We study the constraints experiments will be able to put on the frequency and l-dependence of the tensor signal as a check of its primordial origin. Futuristic ground-based and balloon experiments can have good constraints on these parameters, even for r~2×10-3. For the same value of r, satellites will marginally be able to detect the presence of the recombination bump, the most distinctive feature of the primordial signal.

  19. Detecting primordial B-modes after Planck

    SciTech Connect

    Creminelli, Paolo; Nacir, Diana López; Simonović, Marko; Zaldarriaga, Matias; Trevisan, Gabriele E-mail: dlopez_n@ictp.it E-mail: gt989@nyu.edu

    2015-11-01

    We update the forecasts for the measurement of the tensor-to-scalar ratio r for various ground-based experiments (AdvACT, CLASS, Keck/BICEP3, Simons Array, SPT-3G), balloons (EBEX 10k and Spider) and satellites (CMBPol, COrE and LiteBIRD), taking into account the recent Planck data on polarized dust and using a component separation method. The forecasts do not change significantly with respect to previous estimates when at least three frequencies are available, provided foregrounds can be accurately described by few parameters. We argue that a theoretically motivated goal for future experiments is r∼2×10{sup −3}, and that this is achievable if the noise is reduced to ∼1 μK-arcmin and lensing is reduced to 10% in power. We study the constraints experiments will be able to put on the frequency and ℓ-dependence of the tensor signal as a check of its primordial origin. Futuristic ground-based and balloon experiments can have good constraints on these parameters, even for r∼2×10{sup −3}. For the same value of r, satellites will marginally be able to detect the presence of the recombination bump, the most distinctive feature of the primordial signal.

  20. Planck 2015 results. VI. LFI mapmaking

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Chamballu, A.; Chary, R.-R.; Christensen, P. R.; Colombi, S.; Colombo, L. P. L.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Dickinson, C.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kiiveri, K.; Kisner, T. S.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leahy, J. P.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; Lindholm, V.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Novikov, D.; Novikov, I.; Paci, F.; Pagano, L.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Pierpaoli, E.; Pietrobon, D.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renzi, A.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vassallo, T.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Watson, R.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    This paper describes the mapmaking procedure applied to Planck Low Frequency Instrument (LFI) data. The mapmaking step takes as input the calibrated timelines and pointing information. The main products are sky maps of I, Q, and U Stokes components. For the first time, we present polarization maps at LFI frequencies. The mapmaking algorithm is based on a destriping technique, which is enhanced with a noise prior. The Galactic region is masked to reduce errors arising from bandpass mismatch and high signal gradients. We apply horn-uniform radiometer weights to reduce the effects of beam-shape mismatch. The algorithm is the same as used for the 2013 release, apart from small changes in parameter settings. We validate the procedure through simulations. Special emphasis is put on the control of systematics, which is particularly important for accurate polarization analysis. We also produce low-resolution versions of the maps and corresponding noise covariance matrices. These serve as input in later analysis steps and parameter estimation. The noise covariance matrices are validated through noise Monte Carlo simulations. The residual noise in the map products is characterized through analysis of half-ring maps, noise covariance matrices, and simulations.

  1.  CMB anomalies after Planck

    NASA Astrophysics Data System (ADS)

    Schwarz, Dominik J.; Copi, Craig J.; Huterer, Dragan; Starkman, Glenn D.

    2016-09-01

    Several unexpected features have been observed in the microwave sky at large angular scales, both by WMAP and by Planck. Among those features is a lack of both variance and correlation on the largest angular scales, alignment of the lowest multipole moments with one another and with the motion and geometry of the solar system, a hemispherical power asymmetry or dipolar power modulation, a preference for odd parity modes and an unexpectedly large cold spot in the Southern hemisphere. The individual p-values of the significance of these features are in the per mille to per cent level, when compared to the expectations of the best-fit inflationary ΛCDM model. Some pairs of those features are demonstrably uncorrelated, increasing their combined statistical significance and indicating a significant detection of CMB features at angular scales larger than a few degrees on top of the standard model. Despite numerous detailed investigations, we still lack a clear understanding of these large-scale features, which seem to imply a violation of statistical isotropy and scale invariance of inflationary perturbations. In this contribution we present a critical analysis of our current understanding and discuss several ideas of how to make further progress.

  2. Physics Meets Philosophy at the Planck Scale

    NASA Astrophysics Data System (ADS)

    Callender, Craig; Huggett, Nick

    2001-04-01

    Preface; 1. Introduction Craig Callendar and Nick Huggett; Part I. Theories of Quantum Gravity and their Philosophical Dimensions: 2. Spacetime and the philosophical challenge of quantum gravity Jeremy Butterfield and Christopher Isham; 3. Naive quantum gravity Steven Weinstein; 4. Quantum spacetime: what do we know? Carlo Rovelli; Part II. Strings: 5. Reflections on the fate of spacetime Edward Witten; 6. A philosopher looks at string theory Robert Weingard; 7. Black holes, dumb holes, and entropy William G. Unruh; Part III. Topological Quantum Field Theory: 8. Higher-dimensional algebra and Planck scale physics John C. Baez; Part IV. Quantum Gravity and the Interpretation of General Relativity: 9. On general covariance and best matching Julian B. Barbour; 10. Pre-Socratic quantum gravity Gordon Belot and John Earman; 11. The origin of the spacetime metric: Bell's 'Lorentzian Pedagogy' and its significance in general relativity Harvey R. Brown and Oliver Pooley; Part IV. Quantum Gravity and the Interpretation of Quantum Mechanics: 12. Quantum spacetime without observers: ontological clarity and the conceptual foundations of quantum gravity Sheldon Goldstein and Stefan Teufel; 13. On gravity's role in quantum state reduction Roger Penrose; 14. Why the quantum must yield to gravity Joy Christian.

  3. New z>2 clusters unveiled by Planck, Herschel & Spitzer - prospects for JWST, Euclid, WFIRST

    NASA Astrophysics Data System (ADS)

    Dole, Herve A.

    2015-08-01

    Searching for z>2 clusters/protoclusters is an active field in cosmology, and quite successfull using wide near-infrared surveys (e.g. Spitzer). We present a new approach by selecting highly star forming high-z cluster candidates over the whole sky using Planck, taking benefit of the redshifted far-infrared peak into the Planck submillimetre channels and a clean component separation (among which Galactic cirrus & CMB). Out of more than 1000 Planck high-z candidates, about 230 were confirmed by a Herschel/SPIRE follow-up as significant overdensities of red sources, confirming their high-z spectral energy distribution and high star formation rates (typically 700 Msun/yr per SPIRE source, and >5000 Msun/yr for each structure). These overdensities could be protoclusters in their intense star formation phase. Few targets have spectroscopic redshift (in the NIR and mm) confirmations, all in the range 1.7-2.3, while photometric analysis indicates z>2 for all the Planck counterparts.The key points here are the wavelength plus the angular and resolution coverage from Planck, Herschel and Spitzer. 40 fields were followed-up by Spitzer down to 1uJy 5sigma, and show unambiguous presence of galaxy overdensities compatible with z~2 based on color analysis on 4 band photometry (J, K, 3.6 and 4.5um). These targetted Spitzer observations can serve as pilot project for the more extended data coming in the next decade with JWST and Euclid.This new window on the high-z (z>2) protocluster may yield powerful constraints on structure formation (e.g., SFR vs environnement at high-z, z>2 mass assembly in clusters, bias). Furthermore, these objects will allow to better quantify the prediction for clusters to be detected by WFIRST and Euclid. Finally, these clusters will help us extending the current search for high-z clusters, in nice complementarity with current selections in the near-infrared (dominated by stellar mass) and the millimeter (dominated by hot gas and SZ effect), using the

  4. New z>2 clusters unveiled by Planck, Herschel & Spitzer - prospects for JWST & Euclid

    NASA Astrophysics Data System (ADS)

    Dole, Herve A.

    2015-08-01

    Searching for z>2 clusters/protoclusters is an active field in cosmology, and quite successfull using wide near-infrared surveys (e.g. Spitzer). We present a new approach by selecting highly star forming high-z cluster candidates over the whole sky using Planck, taking benefit of the redshifted far-infrared peak into the Planck submillimetre channels and a clean component separation (among which Galactic cirrus & CMB). Out of more than 1000 Planck high-z candidates, about 230 were confirmed by a Herschel/SPIRE follow-up as significant overdensities of red sources, confirming their high-z spectral energy distribution and high star formation rates (typically 700 Msun/yr per SPIRE source, and >5000 Msun/yr for each structure). These overdensities could be protoclusters in their intense star formation phase. Few targets have spectroscopic redshift (in the NIR and mm) confirmations, all in the range 1.7-2.3, while photometric analysis indicates z>2 for all the Planck counterparts.The key points here are the wavelength plus the angular and resolution coverage from Planck, Herschel and Spitzer. 40 fields were followed-up by Spitzer down to 1uJy 5sigma, and show unambiguous presence of galaxy overdensities compatible with z~2 based on color analysis on 4 band photometry (J, K, 3.6 and 4.5um). These targetted Spitzer observations can serve as pilot project for the more extended data coming in the next decade with JWST and Euclid.This new window on the high-z (z>2) protocluster may yield powerful constraints on structure formation (e.g., SFR vs environnement at high-z, z>2 mass assembly in clusters, bias). Furthermore, these objects will allow to better quantify the prediction for clusters to be detected by WFIRST and Euclid. Finally, these clusters will help us extending the current search for high-z clusters, in nice complementarity with current selections in the near-infrared (dominated by stellar mass) and the millimeter (dominated by hot gas and SZ effect), using the

  5. Signatures of Planck corrections in a spiralling axion inflation model

    SciTech Connect

    McDonald, John

    2015-05-08

    The minimal sub-Planckian axion inflation model accounts for a large scalar-to-tensor ratio via a spiralling trajectory in the field space of a complex field Φ. Here we consider how the predictions of the model are modified by Planck scale-suppressed corrections. In the absence of Planck corrections the model is equivalent to a ϕ{sup 4/3} chaotic inflation model. Planck corrections become important when the dimensionless coupling ξ of |Φ|{sup 2} to the topological charge density of the strongly-coupled gauge sector FF{sup ~} satisfies ξ∼1. For values of |Φ| which allow the Planck corrections to be understood via an expansion in powers of |Φ|{sup 2}/M{sub Pl}{sup 2}, we show that their effect is to produce a significant modification of the tensor-to-scalar ratio from its ϕ{sup 4/3} chaotic inflation value without strongly modifying the spectral index. In addition, to leading order in |Φ|{sup 2}/M{sub Pl}{sup 2}, the Planck modifications of n{sub s} and r satisfy a consistency relation, Δn{sub s}=−Δr/16. Observation of these modifications and their correlation would allow the model to be distinguished from a simple ϕ{sup 4/3} chaotic inflation model and would also provide a signature for the influence of leading-order Planck corrections.

  6. New limits on coupled dark energy from Planck

    SciTech Connect

    Xia, Jun-Qing

    2013-11-01

    Recently, the Planck collaboration has released the first cosmological papers providing the high resolution, full sky, maps of the cosmic microwave background (CMB) temperature anisotropies. It is crucial to understand that whether the accelerating expansion of our universe at present is driven by an unknown energy component (Dark Energy) or a modification to general relativity (Modified Gravity). In this paper we study the coupled dark energy models, in which the quintessence scalar field nontrivially couples to the cold dark matter, with the strength parameter of interaction β. Using the Planck data alone, we obtain that the strength of interaction between dark sectors is constrained as β < 0.102 at 95% confidence level, which is tighter than that from the WMAP9 data alone. Combining the Planck data with other probes, like the Baryon Acoustic Oscillation (BAO), Type-Ia supernovae ''Union2.1 compilation'' and the CMB lensing data from Planck measurement, we find the tight constraint on the strength of interaction β < 0.052 (95% C.L.). Interestingly, we also find a non-zero coupling β = 0.078±0.022 (68% C.L.) when we use the Planck, the ''SNLS'' supernovae samples, and the prior on the Hubble constant from the Hubble Space Telescope (HST) together. This evidence for the coupled dark energy models mainly comes from a tension between constraints on the Hubble constant from the Planck measurement and the local direct H{sub 0} probes from HST.

  7. 4D imaging of protein aggregation in live cells.

    PubMed

    Spokoini, Rachel; Shamir, Maya; Keness, Alma; Kaganovich, Daniel

    2013-01-01

    ubiquitinated are diverted to the IPOD, where they are actively aggregated in a protective compartment. Up until this point, the methodological paradigm of live-cell fluorescence microscopy has largely been to label proteins and track their locations in the cell at specific time-points and usually in two dimensions. As new technologies have begun to grant experimenters unprecedented access to the submicron scale in living cells, the dynamic architecture of the cytosol has come into view as a challenging new frontier for experimental characterization. We present a method for rapidly monitoring the 3D spatial distributions of multiple fluorescently labeled proteins in the yeast cytosol over time. 3D timelapse (4D imaging) is not merely a technical challenge; rather, it also facilitates a dramatic shift in the conceptual framework used to analyze cellular structure. We utilize a cytosolic folding sensor protein in live yeast to visualize distinct fates for misfolded proteins in cellular aggregation quality control, using rapid 4D fluorescent imaging. The temperature sensitive mutant of the Ubc9 protein (Ubc9(ts)) is extremely effective both as a sensor of cellular proteostasis, and a physiological model for tracking aggregation quality control. As with most ts proteins, Ubc9(ts) is fully folded and functional at permissive temperatures due to active cellular chaperones. Above 30 ° C, or when the cell faces misfolding stress, Ubc9(ts) misfolds and follows the fate of a native globular protein that has been misfolded due to mutation, heat denaturation, or oxidative damage. By fusing it to GFP or other fluorophores, it can be tracked in 3D as it forms Stress Foci, or is directed to JUNQ or IPOD. PMID:23608881

  8. GRAM 88 - 4D GLOBAL REFERENCE ATMOSPHERE MODEL-1988

    NASA Technical Reports Server (NTRS)

    Johnson, D. L.

    1994-01-01

    the Jacchia values. Below 25km the atmospheric parameters are computed by the 4-D worldwide atmospheric model of Spiegler and Fowler (1972). This data set is not included. GRAM-88 incorporates a hydrostatic/gas law check in the 0-30 km altitude range to flag and change any bad data points. Between 5km and 30km, an interpolation scheme is used between the 4-D results and the modified Groves values. The output parameters consist of components for: (1) latitude, longitude, and altitude dependent monthly and annual means, (2) quasi-biennial oscillations (QBO), and (3) random perturbations to partially simulate the variability due to synoptic, diurnal, planetary wave, and gravity wave variations. Quasi-biennial and random variation perturbations are computed from parameters determined by various empirical studies and are added to the monthly mean values. The GRAM-88 program is for batch execution on the IBM 3084. It is written in STANDARD FORTRAN 77 under the MVS/XA operating system. The IBM DISPLA graphics routines are necessary for graphical output. The program was developed in 1988.

  9. Gas of 96 Planck Cold Clumps in the Second Quadrant

    NASA Astrophysics Data System (ADS)

    Zhang, Tianwei; Wu, Yuefang; Liu, Tie; Meng, Fanyi

    2016-06-01

    Ninety-six Planck cold dust clumps in the second quadrant were mapped with 12CO (1-0), 13CO (1-0), and C18O (1-0) lines at the 13.7 m telescope of Purple Mountain Observatory. 12CO (1-0) and 13CO (1-0) emissions were detected for all 96 clumps, while C18O (1-0) emissions were detected in 81 of them. Fifteen clumps have more than one velocity component. In the 115 mapped velocity components, 225 cores were obtained. We found that 23.1% of the cores have non-Gaussian profiles. We acquired the V lsr, FWHM, and T A of the lines. Distances, T ex, velocity dispersions, {N}{{{H}}2}, and masses were also derived. Generally, turbulence may dominant the cores because {σ }{NT}/{σ }{Therm}\\gt 1 in almost all of the cores and Larson’s relationship is not apparent in our massive cores. Virial parameters are adopted to test the gravitational stability of cores and 51% of the cores are likely collapsing. The core mass function of the cores in the range 0-1 kpc suggests a low core-to-star conversional efficiency (0.62%). Only 14 of 225 cores (6.2%) have associated stellar objects at their centers, while the others are starless. The morphologies of clumps are mainly filamentary structures. Seven clumps may be located on an extension of the new spiral arm in the second quadrant while three are on the known outer arm.

  10. 4D measurement system for automatic location of anatomical structures

    NASA Astrophysics Data System (ADS)

    Witkowski, Marcin; Sitnik, Robert; Kujawińska, Małgorzata; Rapp, Walter; Kowalski, Marcin; Haex, Bart; Mooshake, Sven

    2006-04-01

    Orthopedics and neurosciences are fields of medicine where the analysis of objective movement parameters is extremely important for clinical diagnosis. Moreover, as there are significant differences between static and dynamic parameters, there is a strong need of analyzing the anatomical structures under functional conditions. In clinical gait analysis the benefits of kinematical methods are undoubted. In this paper we present a 4D (3D + time) measurement system capable of automatic location of selected anatomical structures by locating and tracing the structures' position and orientation in time. The presented system is designed to help a general practitioner in diagnosing selected lower limbs' dysfunctions (e.g. knee injuries) and also determine if a patient should be directed for further examination (e.g. x-ray or MRI). The measurement system components are hardware and software. For the hardware part we adapt the laser triangulation method. In this way we can evaluate functional and dynamic movements in a contact-free, non-invasive way, without the use of potentially harmful radiation. Furthermore, opposite to marker-based video-tracking systems, no preparation time is required. The software part consists of a data acquisition module, an image processing and point clouds (point cloud, set of points described by coordinates (x, y, z)) calculation module, a preliminary processing module, a feature-searching module and an external biomechanical module. The paper briefly presents the modules mentioned above with the focus on the feature-searching module. Also we present some measurement and analysis results. These include: parameters maps, landmarks trajectories in time sequence and animation of a simplified model of lower limbs.

  11. Infrared PINEM developed by diffraction in 4D UEM

    PubMed Central

    Liu, Haihua; Baskin, John Spencer; Zewail, Ahmed H.

    2016-01-01

    The development of four-dimensional ultrafast electron microscopy (4D UEM) has enabled not only observations of the ultrafast dynamics of photon–matter interactions at the atomic scale with ultrafast resolution in image, diffraction, and energy space, but photon–electron interactions in the field of nanoplasmonics and nanophotonics also have been captured by the related technique of photon-induced near-field electron microscopy (PINEM) in image and energy space. Here we report a further extension in the ongoing development of PINEM using a focused, nanometer-scale, electron beam in diffraction space for measurements of infrared-light-induced PINEM. The energy resolution in diffraction mode is unprecedented, reaching 0.63 eV under the 200-keV electron beam illumination, and separated peaks of the PINEM electron-energy spectrum induced by infrared light of wavelength 1,038 nm (photon energy 1.2 eV) have been well resolved for the first time, to our knowledge. In a comparison with excitation by green (519-nm) pulses, similar first-order PINEM peak amplitudes were obtained for optical fluence differing by a factor of more than 60 at the interface of copper metal and vacuum. Under high fluence, the nonlinear regime of IR PINEM was observed, and its spatial dependence was studied. In combination with PINEM temporal gating and low-fluence infrared excitation, the PINEM diffraction method paves the way for studies of structural dynamics in reciprocal space and energy space with high temporal resolution. PMID:26848135

  12. Binary 4D seismic history matching, a metric study

    NASA Astrophysics Data System (ADS)

    Chassagne, Romain; Obidegwu, Dennis; Dambrine, Julien; MacBeth, Colin

    2016-11-01

    This paper explores 4D seismic history matching and it specifically focuses on the objective function used during the optimisation with seismic data. The objective function is calculated by using binary maps, where one map is obtained from the observed seismic data and the other is from one realisation of the optimisation algorithm from the simulation model. In order to decide which set of parameters is a relevant update for the simulation model, an efficient way is required to measure how similar these two binary images are, during their evaluation within the objective function. Behind this aspect of quantification of the similarities or dissimilarities lies the metric notion, or the art of measuring distances. Four metrics are proposed with this study, the well-known Hamming distance, two widely used metrics, the Hausdorff distance and Mutual Information and a recent metric, called the Current Measure Metric. These metrics will be tested and compared on different case scenarios, designed in accordance to a real field case (gas exsolution) before being used in the second part of the paper. Despite its simplicity, the Hamming distance gives positive results, but the Current Measure Metric appears to be a more efficient choice to cover a wider range of scenarios, these conclusions remain true when tested on synthetic and real dataset in a history matching exercise. Some practical aspects of binary map processes will be examined through the paper, as it is shown that it is more proper to use a derivative free optimisation algorithm and a proper metric should be more inclined to capture global features than local features.

  13. Fast interactive exploration of 4D MRI flow data

    NASA Astrophysics Data System (ADS)

    Hennemuth, A.; Friman, O.; Schumann, C.; Bock, J.; Drexl, J.; Huellebrand, M.; Markl, M.; Peitgen, H.-O.

    2011-03-01

    1- or 2-directional MRI blood flow mapping sequences are an integral part of standard MR protocols for diagnosis and therapy control in heart diseases. Recent progress in rapid MRI has made it possible to acquire volumetric, 3-directional cine images in reasonable scan time. In addition to flow and velocity measurements relative to arbitrarily oriented image planes, the analysis of 3-dimensional trajectories enables the visualization of flow patterns, local features of flow trajectories or possible paths into specific regions. The anatomical and functional information allows for advanced hemodynamic analysis in different application areas like stroke risk assessment, congenital and acquired heart disease, aneurysms or abdominal collaterals and cranial blood flow. The complexity of the 4D MRI flow datasets and the flow related image analysis tasks makes the development of fast comprehensive data exploration software for advanced flow analysis a challenging task. Most existing tools address only individual aspects of the analysis pipeline such as pre-processing, quantification or visualization, or are difficult to use for clinicians. The goal of the presented work is to provide a software solution that supports the whole image analysis pipeline and enables data exploration with fast intuitive interaction and visualization methods. The implemented methods facilitate the segmentation and inspection of different vascular systems. Arbitrary 2- or 3-dimensional regions for quantitative analysis and particle tracing can be defined interactively. Synchronized views of animated 3D path lines, 2D velocity or flow overlays and flow curves offer a detailed insight into local hemodynamics. The application of the analysis pipeline is shown for 6 cases from clinical practice, illustrating the usefulness for different clinical questions. Initial user tests show that the software is intuitive to learn and even inexperienced users achieve good results within reasonable processing

  14. The Planck Catalogue of High-z source candidates : A laboratory for high-z star forming galaxies

    NASA Astrophysics Data System (ADS)

    Montier, Ludovic

    2015-08-01

    The Planck satellite has provided the first FIR/submm all-sky survey with a sensitivity allowing us to identify the rarest, most luminous high-z dusty star-forming sources on the sky. It opens a new window on these extreme star-forming systems at redshift above 1.5, providing a powerful laboratory to study the mechanisms of galaxy evolution and enrichment in the frame of the large scale structure growth.I will describe how the Planck catalogue of high-z source candidates (PHz, Planck 2015 in prep.) has been built and charcaterized over 25% of the sky by selecting the brightest red submm sources at a 5' resolution. Follow-up observations with Herschel/SPIRE over 228 Planck candidates have shown that 93% of these candidates are actually overdensities of red sources with SEDs peaking at 350um (Planck Int. results. XXVII 2014). Complementarily to this population of objects, 12 Planck high-z candidates have been identified as strongly lensed star forming galaxies at redshift lying between 2.2 and 3.6 (Canameras et al 2015 subm.), with flux densities larger than 400 mJy up to 1 Jy at 350um, and strong magnification factors. These Planck lensed star-forming galaxies are the rarest brightest lensed in the submm range, providing a unique opportunity to extend the exploration of the star-forming system in this range of mass and redshift.I will detail further a specific analysis performed on a proto-cluster candidate, PHz G95.5-61.6, identified as a double structure at z=1.7 and z=2.03, using an extensive follow-up program (Flores-Cacho et al 2015 subm.). This is the first Planck proto-cluster candidate with spectroscopic confirmation, which opens a new field of statistical analysis about the evolution of dusty star-forming galaxies in such accreting structures.I will finally discuss how the PHz catalogue may help to answer some of the fundamental questions like: At what cosmic epoch did massive galaxy clusters form most of their stars? Is star formation more or less vigorous

  15. Vessels as 4-D curves: global minimal 4-D paths to extract 3-D tubular surfaces and centerlines.

    PubMed

    Li, Hua; Yezzi, Anthony

    2007-09-01

    In this paper, we propose an innovative approach to the segmentation of tubular structures. This approach combines all of the benefits of minimal path techniques such as global minimizers, fast computation, and powerful incorporation of user input, while also having the capability to represent and detect vessel surfaces directly which so far has been a feature restricted to active contour and surface techniques. The key is to represent the trajectory of a tubular structure not as a 3-D curve but to go up a dimension and represent the entire structure as a 4-D curve. Then we are able to fully exploit minimal path techniques to obtain global minimizing trajectories between two user supplied endpoints in order to reconstruct tubular structures from noisy or low contrast 3-D data without the sensitivity to local minima inherent in most active surface techniques. In contrast to standard purely spatial 3-D minimal path techniques, however, we are able to represent a full tubular surface rather than just a curve which runs through its interior. Our representation also yields a natural notion of a tube's "central curve." We demonstrate and validate the utility of this approach on magnetic resonance (MR) angiography and computed tomography (CT) images of coronary arteries. PMID:17896594

  16. partiview: Immersive 4D Interactive Visualization of Large-Scale Simulations

    NASA Astrophysics Data System (ADS)

    Levy, Stuart

    2010-10-01

    In dense clusters a bewildering variety of interactions between stars can be observed, ranging from simple encounters to collisions and other mass-transfer encounters. With faster and special-purpose computers like GRAPE, the amount of data per simulation is now exceeding 1TB. Visualization of such data has now become a complex 4D data-mining problem, combining space and time, and finding interesting events in these large datasets. We have recently starting using the virtual reality simulator, installed in the Hayden Planetarium in the American Museum for Natural History, to tackle some of these problem. partiview is a program that enables you to visualize and animate particle data. partiview runs on relatively simple desktops and laptops, but is mostly compatible with its big brother VirDir.

  17. Seasonal snow of arctic Alaska R4D investigations. Final report

    SciTech Connect

    Benson, C.S.

    1993-02-01

    Seasonal snow is present on the Arctic Slope of Alaska for nine months each year. Its presence or absence determines whether 80% of the solar radiation is reflected or absorbed, respectively. Although life on the Arctic Slope is adapted to, and in some cases dependent upon seasonal snow, little is known about it from a scientific point of view. Its quantity has been grossly underestimated, and knowledge of its distribution and the extent of wind transport and redistribution is very limited. This research project dealt with the amount, regional distribution and physical properties of wind blown snow and its biological role in the R4D area of the Arctic Slope. Physical processes which operate within the snow that were studied included the flux of heat and vapor and the fractionation of stable isotopes through it during fall and winter, and the complex heat and mass transfer within the snow and between snow, its substrate and the overlying atmosphere during the melt period.

  18. Planck intermediate results. XXXVI. Optical identification and redshifts of Planck SZ sources with telescopes at the Canary Islands observatories

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Barrena, R.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bikmaev, I.; Böhringer, H.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Burenin, R.; Burigana, C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Chamballu, A.; Chary, R.-R.; Chiang, H. C.; Chon, G.; Christensen, P. R.; Clements, D. L.; Colombo, L. P. L.; Combet, C.; Comis, B.; Crill, B. P.; Curto, A.; Cuttaia, F.; Dahle, H.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Ferragamo, A.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Fromenteau, S.; Galeotta, S.; Galli, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gruppuso, A.; Hansen, F. K.; Harrison, D. L.; Hempel, A.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, T. R.; Keihänen, E.; Keskitalo, R.; Khamitov, I.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; León-Tavares, J.; Levrier, F.; Lietzen, H.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Melchiorri, A.; Mennella, A.; Migliaccio, M.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Perdereau, O.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Stolyarov, V.; Streblyanska, A.; Sudiwala, R.; Sunyaev, R.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tramonte, D.; Tristram, M.; Tucci, M.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-02-01

    We present the results of approximately three years of observations of Planck Sunyaev-Zeldovich (SZ) sources with telescopes at the Canary Islands observatories as part of the general optical follow-up programme undertaken by the Planck Collaboration. In total, 78 SZ sources are discussed. Deep-imaging observations were obtained for most of these sources; spectroscopic observations in either in long-slit or multi-object modes were obtained for many. We effectively used 37.5 clear nights. We found optical counterparts for 73 of the 78 candidates. This sample includes 53 spectroscopic redshift determinations, 20 of them obtained with a multi-object spectroscopic mode. The sample contains new redshifts for 27 Planck clusters that were not included in the first Planck SZ source catalogue (PSZ1).

  19. 32 CFR 1630.43 - Class 4-D: Minister of religion.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Class 4-D: Minister of religion. 1630.43 Section... CLASSIFICATION RULES § 1630.43 Class 4-D: Minister of religion. In accord with part 1645 of this chapter any registrant shall be placed in Class 4-D who is a: (a) Duly ordained minister of religion; or (b)...

  20. 32 CFR 1630.43 - Class 4-D: Minister of religion.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Class 4-D: Minister of religion. 1630.43 Section... CLASSIFICATION RULES § 1630.43 Class 4-D: Minister of religion. In accord with part 1645 of this chapter any registrant shall be placed in Class 4-D who is a: (a) Duly ordained minister of religion; or (b)...

  1. 32 CFR 1630.43 - Class 4-D: Minister of religion.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Class 4-D: Minister of religion. 1630.43 Section... CLASSIFICATION RULES § 1630.43 Class 4-D: Minister of religion. In accord with part 1645 of this chapter any registrant shall be placed in Class 4-D who is a: (a) Duly ordained minister of religion; or (b)...

  2. 32 CFR 1630.43 - Class 4-D: Minister of religion.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Class 4-D: Minister of religion. 1630.43 Section... CLASSIFICATION RULES § 1630.43 Class 4-D: Minister of religion. In accord with part 1645 of this chapter any registrant shall be placed in Class 4-D who is a: (a) Duly ordained minister of religion; or (b)...

  3. 32 CFR 1630.43 - Class 4-D: Minister of religion.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Class 4-D: Minister of religion. 1630.43 Section... CLASSIFICATION RULES § 1630.43 Class 4-D: Minister of religion. In accord with part 1645 of this chapter any registrant shall be placed in Class 4-D who is a: (a) Duly ordained minister of religion; or (b)...

  4. 40 CFR 180.142 - 2,4-D; tolerances for residues.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false 2,4-D; tolerances for residues. 180..., plant regulator, and fungicide 2,4-D, including its metabolites and degradates, in or on the commodities... 2,4-D (2,4-dichlorophenoxyacetic acid), both free and conjugated, determined as the acid, in or...

  5. Self-tuning at large (distances): 4D description of runaway dilaton capture

    NASA Astrophysics Data System (ADS)

    Burgess, C. P.; Diener, Ross; Williams, M.

    2015-10-01

    We complete here a three-part study (see also arXiv:1506.08095 and arXiv:1508.00856) of how codimension-two objects back-react gravitationally with their environment, with particular interest in situations where the transverse `bulk' is stabilized by the interplay between gravity and flux-quantization in a dilaton-Maxwell-Einstein system such as commonly appears in higher-dimensional supergravity and is used in the Supersymmetric Large Extra Dimensions (SLED) program. Such systems enjoy a classical flat direction that can be lifted by interactions with the branes, giving a mass to the would-be modulus that is smaller than the KK scale. We construct the effective low-energy 4D description appropriate below the KK scale once the transverse extra dimensions are integrated out, and show that it reproduces the predictions of the full UV theory for how the vacuum energy and modulus mass depend on the properties of the branes and stabilizing fluxes. In particular we show how this 4D theory learns the news of flux quantization through the existence of a space-filling four-form potential that descends from the higher-dimensional Maxwell field. We find a scalar potential consistent with general constraints, like the runaway dictated by Weinberg's theorem. We show how scale-breaking brane interactions can give this potential minima for which the extra-dimensional size, ℓ, is exponentially large relative to underlying physics scales, r B , with ℓ 2 = r B 2 e - φ where - φ ≫ 1 can be arranged with a small hierarchy between fundamental parameters. We identify circumstances where the potential at the minimum can (but need not) be parametrically suppressed relative to the tensions of the branes, provide a preliminary discussion of the robustness of these results to quantum corrections, and discuss the relation between what we find and earlier papers in the SLED program.

  6. Mineralization of 2,4-dichlorophenoxyacetic acid (2,4-D) and mixtures of 2,4-D and 2,4,5-trichlorophenoxyacetic acid by Phanerochaete chrysosporium

    SciTech Connect

    Yadav, J.S.; Reddy, C.A. )

    1993-09-01

    2,4-dichloropheonxyacetic Acid (2,4-D) is one of the most commonly used phenoxyalkanoic herbicides for selective control of weeds and for defoliation. Since these toxic chemical are manufactured and used each year in massive quantities, effective handling of their production wastes and the contaminated environment is needed. A number of bacterial general are known to degrade 2,4-D, but no naturally occuring bacterium is know to be capable of mineralizing 2,4,5-trichlorophenoxyacetic acid. Mutual inhibition of degradation has been reported when 2,4-D and 2,4,5-T are presented in a mixture to degrading bacteria. This paper investigates the ability of Pseudomonas chrysosporium to mineralize 2,4-D individually and in combination with 2,4,5-T. Results indicate that P. chrysosporium effectively mineralizes 2,4-D alone as well as in combination with 2,4,5-T. 31 refs., 4 figs., 1 tab.

  7. Planck 2015 results. III. LFI systematic uncertainties

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Basak, S.; Battaglia, P.; Battaner, E.; Benabed, K.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Burigana, C.; Butler, R. C.; Calabrese, E.; Catalano, A.; Christensen, P. R.; Colombo, L. P. L.; Cruz, M.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Dickinson, C.; Diego, J. M.; Doré, O.; Ducout, A.; Dupac, X.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Frailis, M.; Franceschet, C.; Franceschi, E.; Galeotta, S.; Galli, S.; Ganga, K.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Harrison, D. L.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Keihänen, E.; Keskitalo, R.; Kiiveri, K.; Kisner, T. S.; Knoche, J.; Krachmalnicoff, N.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leahy, J. P.; Leonardi, R.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; Lindholm, V.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maffei, B.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Meinhold, P. R.; Mennella, A.; Migliaccio, M.; Mitra, S.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Nati, F.; Natoli, P.; Noviello, F.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Partridge, B.; Pasian, F.; Pearson, T. J.; Perdereau, O.; Pettorino, V.; Piacentini, F.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Puget, J.-L.; Rachen, J. P.; Reinecke, M.; Remazeilles, M.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Scott, D.; Stolyarov, V.; Stompor, R.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Tavagnacco, D.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vassallo, T.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Watson, R.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zibin, J. P.; Zonca, A.

    2016-08-01

    We present the current accounting of systematic effect uncertainties for the Low Frequency Instrument (LFI) that are relevant to the 2015 release of the Planck cosmological results, showing the robustness and consistency of our data set, especially for polarization analysis. We use two complementary approaches: (i) simulations based on measured data and physical models of the known systematic effects; and (ii) analysis of difference maps containing the same sky signal ("null-maps"). The LFI temperature data are limited by instrumental noise. At large angular scales the systematic effects are below the cosmic microwave background (CMB) temperature power spectrum by several orders of magnitude. In polarization the systematic uncertainties are dominated by calibration uncertainties and compete with the CMB E-modes in the multipole range 10-20. Based on our model of all known systematic effects, we show that these effects introduce a slight bias of around 0.2σ on the reionization optical depth derived from the 70GHz EE spectrum using the 30 and 353GHz channels as foreground templates. At 30GHz the systematic effects are smaller than the Galactic foreground at all scales in temperature and polarization, which allows us to consider this channel as a reliable template of synchrotron emission. We assess the residual uncertainties due to LFI effects on CMB maps and power spectra after component separation and show that these effects are smaller than the CMB amplitude at all scales. We also assess the impact on non-Gaussianity studies and find it to be negligible. Some residuals still appear in null maps from particular sky survey pairs, particularly at 30 GHz, suggesting possible straylight contamination due to an imperfect knowledge of the beam far sidelobes.

  8. Gauge-flation confronted with Planck

    SciTech Connect

    Namba, Ryo; Dimastrogiovanni, Emanuela; Peloso, Marco E-mail: ema@physics.umn.edu

    2013-11-01

    Gauge-flation is a recently proposed model in which inflation is driven solely by a non-Abelian gauge field thanks to a specific higher order derivative operator. The nature of the operator is such that it does not introduce ghosts. We compute the cosmological scalar and tensor perturbations for this model, improving over an existing computation. We then confront these results with the Planck data. The model is characterized by the quantity γ ≡ g{sup 2}Q{sup 2}/H{sup 2} (where g is the gauge coupling constant, Q the vector vev, and H the Hubble rate). For γ < 2, the scalar perturbations show a strong tachyonic instability. In the stable region, the scalar power spectrum n{sub s} is too low at small γ, while the tensor-to-scalar ratio r is too high at large γ. No value of γ leads to acceptable values for n{sub s} and r, and so the model is ruled out by the CMB data. The same behavior with γ was obtained in Chromo-natural inflation, a model in which inflation is driven by a pseudo-scalar coupled to a non-Abelian gauge field. When the pseudo-scalar can be integrated out, one recovers the model of Gauge-flation plus corrections. It was shown that this identification is very accurate at the background level, but differences emerged in the literature concerning the perturbations of the two models. On the contrary, our results show that the analogy between the two models continues to be accurate also at the perturbative level.

  9. 4D motion animation of coronary arteries from rotational angiography

    NASA Astrophysics Data System (ADS)

    Holub, Wolfgang; Rohkohl, Christopher; Schuldhaus, Dominik; Prümmer, Marcus; Lauritsch, Günter; Hornegger, Joachim

    2011-03-01

    Time-resolved 3-D imaging of the heart is a major research topic in the medical imaging community. Recent advances in the interventional cardiac 3-D imaging from rotational angiography (C-arm CT) are now also making 4-D imaging feasible during procedures in the catheter laboratory. State-of-the-art reconstruction algorithms try to estimate the cardiac motion and utilize the motion field to enhance the reconstruction of a stable cardiac phase (diastole). The available data offers a handful of opportunities during interventional procedures, e.g. the ECG-synchronized dynamic roadmapping or the computation and analysis of functional parameters. In this paper we will demonstrate that the motion vector field (MVF) that is output by motion compensated image reconstruction algorithms is in general not directly usable for animation and motion analysis. Dependent on the algorithm different defects are investigated. A primary issue is that the MVF needs to be inverted, i.e. the wrong direction of motion is provided. A second major issue is the non-periodicity of cardiac motion. In algorithms which compute a non-periodic motion field from a single rotation the in depth motion information along viewing direction is missing, since this cannot be measured in the projections. As a result, while the MVF improves reconstruction quality, it is insufficient for motion animation and analysis. We propose an algorithm to solve both problems, i.e. inversion and missing in-depth information in a unified framework. A periodic version of the MVF is approximated. The task is formulated as a linear optimization problem where a parametric smooth motion model based on B-splines is estimated from the MVF. It is shown that the problem can be solved using a sparse QR factorization within a clinical feasible time of less than one minute. In a phantom experiment using the publicly available CAVAREV platform, the average quality of a non-periodic animation could be increased by 39% by applying the

  10. Experimenting with the GMAO 4D Data Assimilation

    NASA Technical Reports Server (NTRS)

    Todling, R.; El Akkraoui, A.; Errico, R. M.; Guo, J.; Kim, J.; Kliest, D.; Parrish, D. F.; Suarez, M.; Trayanov, A.; Tremolet, Yannick; Whitaker, J.

    2012-01-01

    The Global Modeling and Assimilation Office (GMAO) has been working to promote its prototype four-dimensional variational (4DVAR) system to a version that can be exercised at operationally desirable configurations. Beyond a general circulation model (GeM) and an analysis system, traditional 4DV AR requires availability of tangent linear (TL) and adjoint (AD) models of the corresponding GeM. The GMAO prototype 4DVAR uses the finite-volume-based GEOS GeM and the Grid-point Statistical Interpolation (GSI) system for the first two, and TL and AD models derived ITom an early version of the finite-volume hydrodynamics that is scientifically equivalent to the present GEOS nonlinear GeM but computationally rather outdated. Specifically, the TL and AD models hydrodynamics uses a simple (I-dimensional) latitudinal MPI domain decomposition, which has consequent low scalability and prevents the prototype 4DV AR ITom being used in realistic applications. In the near future, GMAO will be upgrading its operational GEOS GCM (and assimilation system) to use a cubed-sphere-based hydrodynamics. This versions of the dynamics scales to thousands of processes and has led to a decision to re-derive the TL and AD models for this more modern dynamics, thus taking advantage of a two-dimensional MPI decomposition and improved scalability properties. With the aid of the Transformation of Algorithms in FORTRAN (l'AF) automatic adjoint generation tool and some hand-coding, a version of the cubed-sphere-based TL and AD models, with a simplified vertical diffusion scheme, is now available, enabling multiple configurations of standard implementations of 4DV AR in GEOS. Concurrent to this development, collaboration with the National Centers for Environmental Prediction (NCEP) and the Earth System Research Laboratory (ESRL) has allowed GMAO to implement a hybrid-ensemble capability within the GEOS data assimilation system. Both 3Dand 4D-ensemble capabilities are presently available thus allowing

  11. Predicting lower mantle heterogeneity from 4-D Earth models

    NASA Astrophysics Data System (ADS)

    Flament, Nicolas; Williams, Simon; Müller, Dietmar; Gurnis, Michael; Bower, Dan J.

    2016-04-01

    basal layer ˜ 4% denser than ambient mantle. Increasing convective vigour (Ra ≈ 5 x 108) or decreasing the density of the basal layer decreases both the accuracy and sensitivity of the predicted lower mantle structure. References: D. J. Bower, M. Gurnis, N. Flament, Assimilating lithosphere and slab history in 4-D Earth models. Phys. Earth Planet. Inter. 238, 8-22 (2015). V. Lekic, S. Cottaar, A. Dziewonski, B. Romanowicz, Cluster analysis of global lower mantle tomography: A new class of structure and implications for chemical heterogeneity. Earth Planet. Sci. Lett. 357, 68-77 (2012).

  12. 4D Visualization of Experimental Procedures in Rock Physics

    NASA Astrophysics Data System (ADS)

    Vanorio, T.; di Bonito, C.

    2010-12-01

    Engaging students in laboratory classes in geophysics is becoming more and more difficult. This is primarily because of an ever-widening gap between the less appealing aspects that characterize these courses (e.g., lengthiness of the experimental operations, high student/instrument ratio, limited time associated with lack of previous hands-on experiences, and logistical and safety concerns) and the life style of the 21st century generations (i.e., extensive practice to high-tech tools, high-speed communications and computing, 3D graphics and HD videos). To bridge the gap and enhance the teaching strategy of laboratory courses in geophysics, we have created simulator-training tools for use in preparation for the actual experimental phase. We are using a modeling, animation, and rendering package to create (a) 3D models that accurately reproduce actual scenarios and instruments used for the measurement of rock physics properties and (b) 4D interactive animations that simulate hands-on demonstrations of the experimental procedures. We present here a prototype describing step-by-step the experimental protocol and the principles behind the measurement of rock porosity. The tool reproduces an actual helium porosimeter and makes use of interactive animations, guided text, and a narrative voice guiding the audience through the different phases of the experimental process. Our strategy is to make the most of new technologies while preserving the accuracy of classical laboratory methods and practices. These simulations are not intended to replace traditional lab work; rather they provide students with the opportunity for review and repetition. The primary goal is thus to help students familiarize themselves during their earlier curricula with lab methodologies, thus minimizing apparent hesitation and frustration in later classes. This may also increase the level of interest and involvement of undergraduate students and, in turn, enhance their keenness to pursue their

  13. Interactive 4D Visualization of Sediment Transport Models

    NASA Astrophysics Data System (ADS)

    Butkiewicz, T.; Englert, C. M.

    2013-12-01

    Coastal sediment transport models simulate the effects that waves, currents, and tides have on near-shore bathymetry and features such as beaches and barrier islands. Understanding these dynamic processes is integral to the study of coastline stability, beach erosion, and environmental contamination. Furthermore, analyzing the results of these simulations is a critical task in the design, placement, and engineering of coastal structures such as seawalls, jetties, support pilings for wind turbines, etc. Despite the importance of these models, there is a lack of available visualization software that allows users to explore and perform analysis on these datasets in an intuitive and effective manner. Existing visualization interfaces for these datasets often present only one variable at a time, using two dimensional plan or cross-sectional views. These visual restrictions limit the ability to observe the contents in the proper overall context, both in spatial and multi-dimensional terms. To improve upon these limitations, we use 3D rendering and particle system based illustration techniques to show water column/flow data across all depths simultaneously. We can also encode multiple variables across different perceptual channels (color, texture, motion, etc.) to enrich surfaces with multi-dimensional information. Interactive tools are provided, which can be used to explore the dataset and find regions-of-interest for further investigation. Our visualization package provides an intuitive 4D (3D, time-varying) visualization of sediment transport model output. In addition, we are also integrating real world observations with the simulated data to support analysis of the impact from major sediment transport events. In particular, we have been focusing on the effects of Superstorm Sandy on the Redbird Artificial Reef Site, offshore of Delaware Bay. Based on our pre- and post-storm high-resolution sonar surveys, there has significant scour and bedform migration around the

  14. Serum Sema4D levels are associated with lumbar spine bone mineral density and bone turnover markers in patients with postmenopausal osteoporosis

    PubMed Central

    Zhang, Yiyuan; Feng, Eryou; Xu, Yang; Wang, Wulian; Zhang, Tao; Xiao, Lili; Chen, Rong; Lin, Yu; Chen, Dongdong; Lin, Liqiong; Chen, Kangyao; Lin, Yanbin

    2015-01-01

    To investigate the association of serum semaphorin 4D (Sema4D) levels with lumbar spine bone mineral density (BMD) and bone turnover markers in patients with postmenopausal osteoporosis (PO). Lumbar spine BMD was measured by dual-energy X-ray absorptiometry in 257 PO patients (aged from 50 to 75) and 90 healthy controls (aged from 51 to 83). Serum Sema4D, BAP, BGP and TRACP-5b levels were measured by enzyme linked immunosorbent assay. Serum cross linked N-telopeptides of type I (NTX), 25-hydroxyvitamin D (25(OH)D) and N-mid fragment of osteocalcin (N-MID-OT) levels were measured using automated electrochemiluminescence system. Sema4D level was significantly higher in PO women compared to healthy controls (1.40±0.33 vs. 0.58±0.18 μg/L, P=0.006). Sema4D level was positively correlated with serumTRACP-5b and NTX levels and negatively correlated with lumbar spine BMD and serum BAP and BGP levels. There were no correlations between Sema4D level and age, body mass index, and serum 25(OH)D and N-MID-OT levels. Lumbar spine BMD (β=-0.354, P<0.001) and serum BAP level (β=0.127, P=0.019) were independent predictors of serum Sema4D level in PO patients. Sema4D may be involved in the pathogenesis of PO and play a critical role in bone formation and resorption. Sema4D may represent a novel therapeutic target for treatment of PO and function as a predictive indicator of PO. PMID:26629156

  15. SZ effects in the Magneticum Pathfinder Simulation: Comparison with the Planck, SPT, and ACT results

    NASA Astrophysics Data System (ADS)

    Dolag, K.; Komatsu, E.; Sunyaev, R.

    2016-08-01

    We calculate the one-point probability density distribution functions (PDF) and the power spectra of the thermal and kinetic Sunyaev-Zeldovich (tSZ and kSZ) effects and the mean Compton Y parameter using the Magneticum Pathfinder simulations, state-of-the-art cosmological hydrodynamical simulations of a large cosmological volume of (896 Mpc/h)3. These simulations follow in detail the thermal and chemical evolution of the intracluster medium as well as the evolution of super-massive black holes and their associated feedback processes. We construct full-sky maps of tSZ and kSZ from the light-cones out to z = 0.17, and one realisation of 8°.8 × 8°.8 deep light-cone out to z = 5.2. The local universe at z < 0.027 is simulated by a constrained realisation. The tail of the one-point PDF of tSZ from the deep light-cone follows a power-law shape with an index of -3.2. Once convolved with the effective beam of Planck, it agrees with the PDF measured by Planck. The predicted tSZ power spectrum agrees with that of the Planck data at all multipoles up to l ≈ 1000, once the calculations are scaled to the Planck 2015 cosmological parameters with Ωm = 0.308 and σ8 = 0.8149. Consistent with the results in the literature, however, we continue to find the tSZ power spectrum at l = 3000 that is significantly larger than that estimated from the high-resolution ground-based data. The simulation predicts the mean fluctuating Compton Y value of bar{Y}=1.18× 10^{-6} for Ωm = 0.272 and σ8 = 0.809. Nearly half (≈5 × 10-7) of the signal comes from halos below a virial mass of 1013 M⊙/h. Scaling this to the Planck 2015 parameters, we find bar{Y}=1.57× {}10^{-6}.

  16. Ig-like transcript 4 as a cellular receptor for soluble complement fragment C4d.

    PubMed

    Hofer, Johannes; Forster, Florian; Isenman, David E; Wahrmann, Markus; Leitner, Judith; Hölzl, Markus A; Kovarik, Johannes J; Stockinger, Hannes; Böhmig, Georg A; Steinberger, Peter; Zlabinger, Gerhard J

    2016-04-01

    Complement regulation leads to the generation of complement split products (CSPs) such as complement component (C)4d, a marker for disease activity in autoimmune syndromes or antibody-mediated allograft rejection. However, the physiologic role of C4d has been unknown. By screening murine thymoma BW5147 cells expressing a cDNA library generated from human monocyte-derived dendritic cells with recombinant human C4d, we identified Ig-like transcript (ILT)4 and ILT5v2 as cellular receptors for C4d. Both receptors, expressed on monocytes, macrophages, and dendritic cells, also interacted with the CSPs C3d, C4b, C3b, and iC3b. However, C4d did not bind to classic complement receptors (CRs). Interaction between cell surface-resident ILT4 and soluble monomeric C4d resulted in endocytosis of C4d. Surprisingly, binding of soluble ILT4 to C4d covalently immobilized to a cellular surface following classic complement activation could not be detected. Remarkably, C4d immobilized to a solid phaseviaits intrinsic thioester conferred a dose-dependent inhibition of TNF-α and IL-6 secretion in monocytes activatedviaFc-cross-linking of up to 50% as compared to baseline. Similarly, C4d conferred an attenuation of intracellular Ca(2+)flux in monocytes activatedviaFc-cross-linking. In conclusion, ILT4 represents a scavenger-type endocytotic CR for soluble monomeric C4d, whereas attenuation of monocyte activation by physiologically oriented C4d on a surface appears to be dependent on a yet to be identified C4d receptor.-Hofer, J., Forster, F., Isenman, D. E., Wahrmann, M., Leitner, J., Hölzl, M. A., Kovarik, J. K., Stockinger, H., Böhmig, G. A., Steinberger, P., Zlabinger, G. J. Ig-like transcript 4 as a cellular receptor for soluble complement fragment C4d.

  17. Planck intermediate results. XXV. The Andromeda galaxy as seen by Planck

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Battaner, E.; Battye, R.; Benabed, K.; Bendo, G. J.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Chamballu, A.; Chary, R.-R.; Chen, X.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Dickinson, C.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Israel, F. P.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Madden, S.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; Mendes, L.; Mennella, A.; Migliaccio, M.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Partridge, B.; Pasian, F.; Pearson, T. J.; Peel, M.; Perdereau, O.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Savini, G.; Scott, D.; Spencer, L. D.; Stolyarov, V.; Sudiwala, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Watson, R.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2015-10-01

    The Andromeda galaxy (M 31) is one of a few galaxies that has sufficient angular size on the sky to be resolved by the Planck satellite. Planck has detected M 31 in all of its frequency bands, and has mapped out the dust emission with the High Frequency Instrument, clearly resolving multiple spiralarms and sub-features. We examine the morphology of this long-wavelength dust emission as seen by Planck, including a study of its outermost spiral arms, and investigate the dust heating mechanism across M 31. We find that dust dominating the longer wavelength emission (≳0.3 mm) is heated by the diffuse stellar population (as traced by 3.6 μm emission), with the dust dominating the shorter wavelength emission heated by a mix of the old stellar population and star-forming regions (as traced by 24 μm emission). We also fit spectral energy distributions for individual 5' pixels and quantify the dust properties across the galaxy, taking into account these different heating mechanisms, finding that there is a linear decrease in temperature with galactocentric distance for dust heated by the old stellar population, as would be expected, with temperatures ranging from around 22 K in the nucleus to 14 K outside of the 10 kpc ring. Finally, we measure the integrated spectrum of the whole galaxy, which we find to be well-fitted with a global dust temperature of (18.2 ± 1.0) K with a spectral index of 1.62 ± 0.11 (assuming a single modified blackbody), and a significant amount of free-free emission at intermediate frequencies of 20-60 GHz, which corresponds to a star formation rate of around 0.12 M⊙ yr-1. We find a 2.3σ detection of the presence of spinning dust emission, with a 30 GHz amplitude of 0.7 ± 0.3 Jy, which is in line with expectations from our Galaxy.

  18. Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy

    PubMed Central

    Martin, Tamara P.; Hortigon-Vinagre, Maria P.; Findlay, Jane E.; Elliott, Christina; Currie, Susan; Baillie, George S.

    2014-01-01

    Phosphorylated heat shock protein 20 (HSP20) is cardioprotective. Using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and a mouse model of pressure overload mediated hypertrophy, we show that peptide disruption of the HSP20–phosphodiesterase 4D (PDE4D) complex results in attenuation of action potential prolongation and protection against adverse cardiac remodelling. The later was evidenced by improved contractility, decreased heart weight to body weight ratio, and reduced interstitial and perivascular fibrosis. This study demonstrates that disruption of the specific HSP20–PDE4D interaction leads to attenuation of pathological cardiac remodelling. PMID:25426411

  19. Observations of high-z galaxies with Planck and Herschel

    NASA Astrophysics Data System (ADS)

    Toffolatti, L.; Negrello, M.; González-Nuevo, J.; de Zotti, G.; Magliocchetti, M.

    medskip In the recent past sub-mm and mm-wave surveys have led to the discovery of very luminous high- z galaxies with star formation rates sim 10 3 M odot yr The bright portion of number counts of these sources appears to be declining steeply with increasing flux density reflecting the exponential fall of the dark-halo mass function foreseen by the Press Schechter formula moreover preliminary data show that they are strongly clustered The current astrophysical explanation e g Granato G L it et al 2004 ApJ 600 580 is in terms of very massive proto-spheroidal galaxies undergoing their main phase of star formation at substantial redshift typically z simeq 2 - 3 Given the wide redshift range spanned by them proto-spheroids will provide a unique opportunity to investigate the formation and evolution of large-scale structure up to high redshift Moreover they have a substantial optical depth for gravitational lensing and the effect of lensing results strongly amplified by the steepness of their bright counts medskip In this scenario - in which massive proto-spheroidal galaxies live in strongly overdense regions - a low resolution instrument like Planck cannot measure the flux of individual objects but the sum of fluxes of physically related sources in a resolution element an unresolved source clump Analytic estimates as well as numerical simulations Negrello M it et al 2005 MNRAS 358 869 Gonz alez-Nuevo J it et al 2005 ApJ 621 1 show that several clumps should be detectable by

  20. Planck Visualization Project: Seeing and Hearing the Cosmic Microwave Background

    NASA Astrophysics Data System (ADS)

    van der Veen, J.

    2010-08-01

    The Planck Mission, launched May 14, 2009, will measure the sky over nine frequency channels, with temperature sensitivity of a few microKelvin, and angular resolution of up to 5 arc minutes. Planck is expected to provide the data needed to set tight constraints on cosmological parameters, study the ionization history of the Universe, probe the dynamics of the inflationary era, and test fundamental physics. The Planck Education and Public Outreach collaborators at NASA's Jet Propulsion Laboratory, the University of California, Santa Barbara and Purdue University are preparing a variety of materials to present the science goals of the Planck Mission to the public. Two products currently under development are an interactive simulation of the mission which can be run in a virtual reality environment, and an interactive presentation on interpreting the power spectrum of the Cosmic Microwave Background with music. In this paper we present a brief overview of CMB research and the Planck Mission, and discuss how to explain, to non-technical audiences, the theory of how we derive information about the early universe from the power spectrum of the CMB by using the physics of music.

  1. Max Planck and the birth of the quantum hypothesis

    NASA Astrophysics Data System (ADS)

    Nauenberg, Michael

    2016-09-01

    Based on the functional dependence of entropy on energy, and on Wien's distribution for black-body radiation, Max Planck obtained a formula for this radiation by an interpolation relation that fitted the experimental measurements of thermal radiation at the Physikalisch Technishe Reichanstalt (PTR) in Berlin in the late 19th century. Surprisingly, his purely phenomenological result turned out to be not just an approximation, as would have been expected, but an exact relation. To obtain a physical interpretation for his formula, Planck then turned to Boltzmann's 1877 paper on the statistical interpretation of entropy, which led him to introduce the fundamental concept of energy discreteness into physics. A novel aspect of our account that has been missed in previous historical studies of Planck's discovery is to show that Planck could have found his phenomenological formula partially derived in Boltzmann's paper in terms of a variational parameter. But the dependence of this parameter on temperature is not contained in this paper, and it was first derived by Planck.

  2. Planck-scale-modified dispersion relations in FRW spacetime

    NASA Astrophysics Data System (ADS)

    Rosati, Giacomo; Amelino-Camelia, Giovanni; Marcianò, Antonino; Matassa, Marco

    2015-12-01

    In recent years, Planck-scale modifications of the dispersion relation have been attracting increasing interest also from the viewpoint of possible applications in astrophysics and cosmology, where spacetime curvature cannot be neglected. Nonetheless, the interplay between Planck-scale effects and spacetime curvature is still poorly understood, particularly in cases where curvature is not constant. These challenges have been so far postponed by relying on an ansatz, first introduced by Jacob and Piran. We propose here a general strategy of analysis of the effects of modifications of the dispersion relation in Friedmann-Robertson-Walker spacetimes, applicable both to cases where the relativistic equivalence of frames is spoiled ("preferred-frame scenarios") and to the alternative possibility of "DSR-relativistic theories," theories that are fully relativistic but with relativistic laws deformed so that the modified dispersion relation is observer independent. We show that the Jacob-Piran ansatz implicitly assumes that spacetime translations are not affected by the Planck scale, while under rather general conditions, the same Planck-scale quantum-spacetime structures producing modifications of the dispersion relation also affect translations. Through the explicit analysis of one of the effects produced by modifications of the dispersion relation, an effect amounting to Planck-scale corrections to travel times, we show that our concerns are not merely conceptual but rather can have significant quantitative implications.

  3. Cross-correlation of gravitational lensing from DES Science Verification data with SPT and Planck lensing

    NASA Astrophysics Data System (ADS)

    Kirk, D.; Omori, Y.; Benoit-Lévy, A.; Cawthon, R.; Chang, C.; Larsen, P.; Amara, A.; Bacon, D.; Crawford, T. M.; Dodelson, S.; Fosalba, P.; Giannantonio, T.; Holder, G.; Jain, B.; Kacprzak, T.; Lahav, O.; MacCrann, N.; Nicola, A.; Refregier, A.; Sheldon, E.; Story, K. T.; Troxel, M. A.; Vieira, J. D.; Vikram, V.; Zuntz, J.; Abbott, T. M. C.; Abdalla, F. B.; Becker, M. R.; Benson, B. A.; Bernstein, G. M.; Bernstein, R. A.; Bleem, L. E.; Bonnett, C.; Bridle, S. L.; Brooks, D.; Buckley-Geer, E.; Burke, D. L.; Capozzi, D.; Carlstrom, J. E.; Rosell, A. Carnero; Kind, M. Carrasco; Carretero, J.; Crocce, M.; Cunha, C. E.; D'Andrea, C. B.; da Costa, L. N.; Desai, S.; Diehl, H. T.; Dietrich, J. P.; Doel, P.; Eifler, T. F.; Evrard, A. E.; Flaugher, B.; Frieman, J.; Gerdes, D. W.; Goldstein, D. A.; Gruen, D.; Gruendl, R. A.; Honscheid, K.; James, D. J.; Jarvis, M.; Kent, S.; Kuehn, K.; Kuropatkin, N.; Lima, M.; March, M.; Martini, P.; Melchior, P.; Miller, C. J.; Miquel, R.; Nichol, R. C.; Ogando, R.; Plazas, A. A.; Reichardt, C. L.; Roodman, A.; Rozo, E.; Rykoff, E. S.; Sako, M.; Sanchez, E.; Scarpine, V.; Schubnell, M.; Sevilla-Noarbe, I.; Simard, G.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Thomas, D.; Wechsler, R. H.; Weller, J.

    2016-06-01

    We measure the cross-correlation between weak lensing of galaxy images and of the cosmic microwave background (CMB). The effects of gravitational lensing on different sources will be correlated if the lensing is caused by the same mass fluctuations. We use galaxy shape measurements from 139 deg2 of the Dark Energy Survey (DES) Science Verification data and overlapping CMB lensing from the South Pole Telescope (SPT) and Planck. The DES source galaxies have a median redshift of zmed ˜ 0.7, while the CMB lensing kernel is broad and peaks at z ˜ 2. The resulting cross-correlation is maximally sensitive to mass fluctuations at z ˜ 0.44. Assuming the Planck 2015 best-fitting cosmology, the amplitude of the DES×SPT cross-power is found to be ASPT = 0.88 ± 0.30 and that from DES×Planck to be APlanck = 0.86 ± 0.39, where A = 1 corresponds to the theoretical prediction. These are consistent with the expected signal and correspond to significances of 2.9σ and 2.2σ, respectively. We demonstrate that our results are robust to a number of important systematic effects including the shear measurement method, estimator choice, photo-z uncertainty and CMB lensing systematics. We calculate a value of A = 1.08 ± 0.36 for DES×SPT when we correct the observations with a simple intrinsic alignment model. With three measurements of this cross-correlation now existing in the literature, there is not yet reliable evidence for any deviation from the expected LCDM level of cross-correlation. We provide forecasts for the expected signal-to-noise ratio of the combination of the five-year DES survey and SPT-3G.

  4. Tracing gas and magnetic field with dust : lessons from Planck & Herschel

    NASA Astrophysics Data System (ADS)

    Guillet, Vincent

    2015-08-01

    Dust emission is a powerful tool to measure the gas mass. Its polarization also traces the magnetic field structure. With the Planck and Herschel multi-wavelength observations, we are now able to trace the gas and magnetic field over the full sky, with a large spectrum of scales, and up to high optical depths. But a question arises : is dust a reliable tracer ?I will present the statistical properties of the dust polarized emission as observed by Planck HFI over the full sky, and show how this compares to ancillary measures of starlight polarization in the optical, and to MHD simulations. I will distinguish between what is related to the 3D structure of the magnetic field, and what is related to dust (alignement efficiency, grain shape). I will show that the main features of dust polarization observed by Planck can be explained by the magnetic field structure on the line of sight, without any need for a variation of dust alignment efficiency up to an Av of 5 to 10. Dust polarization is therefore a good and reliable tracer of the magnetic field, at least at moderate extinction.I will also discuss the caveats in deriving the gas mass or dust extinction from a fit to the dust spectral energy distribution : 1) the dust far-infrared opacity is not uniform but varies accross the diffuse ISM, and increases inside star-forming regions; 2) Radiation transfer effects must be taken into account at high optical depths. I will present estimates for the systematic errors that are made when these effects are ignored.

  5. A set of 4D pediatric XCAT reference phantoms for multimodality research

    SciTech Connect

    Norris, Hannah Zhang, Yakun; Bond, Jason; Sturgeon, Gregory M.; Samei, E.; Segars, W. P.; Minhas, Anum; Frush, D.; Tward, Daniel J.; Ratnanather, J. T.; Miller, M. I.

    2014-03-15

    Purpose: The authors previously developed an adult population of 4D extended cardiac-torso (XCAT) phantoms for multimodality imaging research. In this work, the authors develop a reference set of 4D pediatric XCAT phantoms consisting of male and female anatomies at ages of newborn, 1, 5, 10, and 15 years. These models will serve as the foundation from which the authors will create a vast population of pediatric phantoms for optimizing pediatric CT imaging protocols. Methods: Each phantom was based on a unique set of CT data from a normal patient obtained from the Duke University database. The datasets were selected to best match the reference values for height and weight for the different ages and genders according to ICRP Publication 89. The major organs and structures were segmented from the CT data and used to create an initial pediatric model defined using nonuniform rational B-spline surfaces. The CT data covered the entire torso and part of the head. To complete the body, the authors manually added on the top of the head and the arms and legs using scaled versions of the XCAT adult models or additional models created from cadaver data. A multichannel large deformation diffeomorphic metric mapping algorithm was then used to calculate the transform from a template XCAT phantom (male or female 50th percentile adult) to the target pediatric model. The transform was applied to the template XCAT to fill in any unsegmented structures within the target phantom and to implement the 4D cardiac and respiratory models in the new anatomy. The masses of the organs in each phantom were matched to the reference values given in ICRP Publication 89. The new reference models were checked for anatomical accuracy via visual inspection. Results: The authors created a set of ten pediatric reference phantoms that have the same level of detail and functionality as the original XCAT phantom adults. Each consists of thousands of anatomical structures and includes parameterized models

  6. A set of 4D pediatric XCAT reference phantoms for multimodality research

    PubMed Central

    Norris, Hannah; Zhang, Yakun; Bond, Jason; Sturgeon, Gregory M.; Minhas, Anum; Tward, Daniel J.; Ratnanather, J. T.; Miller, M. I.; Frush, D.; Samei, E.; Segars, W. P.

    2014-01-01

    Purpose: The authors previously developed an adult population of 4D extended cardiac-torso (XCAT) phantoms for multimodality imaging research. In this work, the authors develop a reference set of 4D pediatric XCAT phantoms consisting of male and female anatomies at ages of newborn, 1, 5, 10, and 15 years. These models will serve as the foundation from which the authors will create a vast population of pediatric phantoms for optimizing pediatric CT imaging protocols. Methods: Each phantom was based on a unique set of CT data from a normal patient obtained from the Duke University database. The datasets were selected to best match the reference values for height and weight for the different ages and genders according to ICRP Publication 89. The major organs and structures were segmented from the CT data and used to create an initial pediatric model defined using nonuniform rational B-spline surfaces. The CT data covered the entire torso and part of the head. To complete the body, the authors manually added on the top of the head and the arms and legs using scaled versions of the XCAT adult models or additional models created from cadaver data. A multichannel large deformation diffeomorphic metric mapping algorithm was then used to calculate the transform from a template XCAT phantom (male or female 50th percentile adult) to the target pediatric model. The transform was applied to the template XCAT to fill in any unsegmented structures within the target phantom and to implement the 4D cardiac and respiratory models in the new anatomy. The masses of the organs in each phantom were matched to the reference values given in ICRP Publication 89. The new reference models were checked for anatomical accuracy via visual inspection. Results: The authors created a set of ten pediatric reference phantoms that have the same level of detail and functionality as the original XCAT phantom adults. Each consists of thousands of anatomical structures and includes parameterized models

  7. Heterogeneous photocatalytic ozonation of 2,4-D in dilute aqueous solution with TiO2 fiber.

    PubMed

    Giri, R R; Ozaki, H; Takanami, R; Taniguchi, S

    2008-01-01

    Photocatalytic ozonation (O(3)/UV/TiO2) is an emerging oxidation method for recalcitrant organic contaminants in water. However, immobilised TiO2 catalysts suffer from reduced photonic efficiency. Therefore, TiO2 catalysts with excellent mechanical and thermal properties and enhanced photonic efficiencies are sought. This paper aimed to elucidate the mineralisation of low concentration 2,4-D (45.0 microM) by O(3)/UV/TiO2 using the world's first high-strength TiO2 fibre in laboratory batch experiments. 2,4-D degradation and TOC removal followed pseudo first-order reaction kinetic. The removal rates for 2,4-D and TOC in O(3)/UV/TiO2 were 1.5 and 2.4-fold larger than the summation of the values for ozonation (O3)) and photocatalysis (UV/TiO2), respectively. O(3)/UV/TiO2 was characterised by few aromatic intermediates with low abundance, fast degradations of aliphatic intermediates and dechlorination as a major step. The significantly enhanced 2,4-D mineralisation in O(3)/UV/TiO2 was attributed to increased ozone dissolution and decomposition, and reduced electron-hole recombination resulting in large number of hydroxyl radical (*OH) formation from more than one parallel path. The discrepancies in the organic carbon mass budget were attributed to few apparently major unidentified intermediates, while chlorine mass balance was reasonably acceptable. The mineralisation efficiency of O(3)/UV/TiO2 with the TiO2 fibre can further be enhanced by optimisation of experimental design parameters. The new TiO2 fibre is very promising to overcome the problem of reduced efficiency of TiO2 catalyst in an immobilised state. PMID:18653956

  8. SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease.

    PubMed

    Smith, Ernest S; Jonason, Alan; Reilly, Christine; Veeraraghavan, Janaki; Fisher, Terrence; Doherty, Michael; Klimatcheva, Ekaterina; Mallow, Crystal; Cornelius, Chad; Leonard, John E; Marchi, Nicola; Janigro, Damir; Argaw, Azeb Tadesse; Pham, Trinh; Seils, Jennifer; Bussler, Holm; Torno, Sebold; Kirk, Renee; Howell, Alan; Evans, Elizabeth E; Paris, Mark; Bowers, William J; John, Gareth; Zauderer, Maurice

    2015-01-01

    Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune cell infiltration of CNS, blood-brain barrier (BBB) breakdown, localized myelin destruction, and progressive neuronal degeneration. There exists a significant need to identify novel therapeutic targets and strategies that effectively and safely disrupt and even reverse disease pathophysiology. Signaling cascades initiated by semaphorin 4D (SEMA4D) induce glial activation, neuronal process collapse, inhibit migration and differentiation of oligodendrocyte precursor cells (OPCs), and disrupt endothelial tight junctions forming the BBB. To target SEMA4D, we generated a monoclonal antibody that recognizes mouse, rat, monkey and human SEMA4D with high affinity and blocks interaction between SEMA4D and its cognate receptors. In vitro, anti-SEMA4D reverses the inhibitory effects of recombinant SEMA4D on OPC survival and differentiation. In vivo, anti-SEMA4D significantly attenuates experimental autoimmune encephalomyelitis in multiple rodent models by preserving BBB integrity and axonal myelination and can be shown to promote migration of OPC to the site of lesions and improve myelin status following chemically-induced demyelination. Our study underscores SEMA4D as a key factor in CNS disease and supports the further development of antibody-based inhibition of SEMA4D as a novel therapeutic strategy for MS and other neurologic diseases with evidence of demyelination and/or compromise to the neurovascular unit. PMID:25461192

  9. The Rab GTPase RabA4d regulates pollen tube tip growth in Arabidopsis thaliana.

    PubMed

    Szumlanski, Amy L; Nielsen, Erik

    2009-02-01

    During reproduction in flowering plants, pollen grains form a tube that grows in a polarized fashion through the female tissues to eventually fertilize the egg cell. These highly polarized pollen tubes have a rapid rate of growth that is supported by a tip-focused delivery of membrane and cell wall components. To gain a better understanding of how this growth is regulated, we investigated the function RABA4D, a member of the Arabidopsis thaliana RabA4 subfamily of Rab GTPase proteins. Here, we show that RABA4D was expressed in a pollen-specific manner and that enhanced yellow fluorescent protein (EYFP)-RabA4d-labeled membrane compartments localized to the tips of growing pollen tubes. Mutant pollen in which the RABA4D gene was disrupted displayed bulged pollen tubes with a reduced rate of growth in vitro and displayed altered deposition of some cell wall components. Expression of EYFP-RabA4d restored wild-type phenotypes to the raba4d mutant pollen tubes, while expression of EYFP-RabA4b did not rescue the raba4d phenotype. In vivo, disruption of RABA4D resulted in a male-specific transmission defect with mutant raba4d pollen tubes displaying aberrant growth in the ovary and reduced guidance at the micropyle. We propose that RabA4d plays an important role in the regulation of pollen tube tip growth.

  10. SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease.

    PubMed

    Smith, Ernest S; Jonason, Alan; Reilly, Christine; Veeraraghavan, Janaki; Fisher, Terrence; Doherty, Michael; Klimatcheva, Ekaterina; Mallow, Crystal; Cornelius, Chad; Leonard, John E; Marchi, Nicola; Janigro, Damir; Argaw, Azeb Tadesse; Pham, Trinh; Seils, Jennifer; Bussler, Holm; Torno, Sebold; Kirk, Renee; Howell, Alan; Evans, Elizabeth E; Paris, Mark; Bowers, William J; John, Gareth; Zauderer, Maurice

    2015-01-01

    Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune cell infiltration of CNS, blood-brain barrier (BBB) breakdown, localized myelin destruction, and progressive neuronal degeneration. There exists a significant need to identify novel therapeutic targets and strategies that effectively and safely disrupt and even reverse disease pathophysiology. Signaling cascades initiated by semaphorin 4D (SEMA4D) induce glial activation, neuronal process collapse, inhibit migration and differentiation of oligodendrocyte precursor cells (OPCs), and disrupt endothelial tight junctions forming the BBB. To target SEMA4D, we generated a monoclonal antibody that recognizes mouse, rat, monkey and human SEMA4D with high affinity and blocks interaction between SEMA4D and its cognate receptors. In vitro, anti-SEMA4D reverses the inhibitory effects of recombinant SEMA4D on OPC survival and differentiation. In vivo, anti-SEMA4D significantly attenuates experimental autoimmune encephalomyelitis in multiple rodent models by preserving BBB integrity and axonal myelination and can be shown to promote migration of OPC to the site of lesions and improve myelin status following chemically-induced demyelination. Our study underscores SEMA4D as a key factor in CNS disease and supports the further development of antibody-based inhibition of SEMA4D as a novel therapeutic strategy for MS and other neurologic diseases with evidence of demyelination and/or compromise to the neurovascular unit.

  11. The ν2GC Simulations : Quantifying the Dark Side of the Universe in the Planck Cosmology

    NASA Astrophysics Data System (ADS)

    Ishiyama, Tomoaki

    2015-08-01

    We present the evolution of dark matter halos in six large cosmological N-body simulations, called the ν2GC (New Numerical Galaxy Catalog) simulations on the basis of the LCDM cosmology consistent with observational results obtained by the Planck satellite. The largest simulation consists of 81923 (550 billion) dark matter particles in a box of 1.12h-1Gpc (a mass resolution of 2.20×108 h-1M⊙). Among simulations utilizing boxes larger than 1h-1Gpc, our simulation yields the highest resolution simulation that has ever been achieved. Compared with the Millennium simulation (Springel et al. 2005), our simulation offers the advantages of a mass resolution that is four times better and a spatial volume that is 11 times larger. A ν2GC simulation with the smallest box consists of eight billions particles in a box of 70h-1Mpc (a mass resolution of 3.44×106 -1M⊙). These simulations can follow the evolution of halos over masses of eight orders of magnitude, from small dwarf galaxies to massive clusters. Using the unprecedentedly high resolution and powerful statistics of the ν2GC simulations, we provide statistical results of the halo mass function, mass accretion rate, formation redshift, and merger statistics, and present accurate fitting functions for the Planck cosmology, from redshift 10 to 0. By combining the ν2GC simulations with our new semi-analytic galaxy formation model, we are able to prepare mock catalogs of galaxies and active galactic nuclei, which will be made publicly available in the near future.

  12. Geometric validation of self-gating k-space-sorted 4D-MRI vs 4D-CT using a respiratory motion phantom

    SciTech Connect

    Yue, Yong Yang, Wensha; McKenzie, Elizabeth; Tuli, Richard; Wallace, Robert; Fraass, Benedick; Fan, Zhaoyang; Pang, Jianing; Deng, Zixin; Li, Debiao

    2015-10-15

    Purpose: MRI is increasingly being used for radiotherapy planning, simulation, and in-treatment-room motion monitoring. To provide more detailed temporal and spatial MR data for these tasks, we have recently developed a novel self-gated (SG) MRI technique with advantage of k-space phase sorting, high isotropic spatial resolution, and high temporal resolution. The current work describes the validation of this 4D-MRI technique using a MRI- and CT-compatible respiratory motion phantom and comparison to 4D-CT. Methods: The 4D-MRI sequence is based on a spoiled gradient echo-based 3D projection reconstruction sequence with self-gating for 4D-MRI at 3 T. Respiratory phase is resolved by using SG k-space lines as the motion surrogate. 4D-MRI images are reconstructed into ten temporal bins with spatial resolution 1.56 × 1.56 × 1.56 mm{sup 3}. A MRI-CT compatible phantom was designed to validate the performance of the 4D-MRI sequence and 4D-CT imaging. A spherical target (diameter 23 mm, volume 6.37 ml) filled with high-concentration gadolinium (Gd) gel is embedded into a plastic box (35 × 40 × 63 mm{sup 3}) and stabilized with low-concentration Gd gel. The phantom, driven by an air pump, is able to produce human-type breathing patterns between 4 and 30 respiratory cycles/min. 4D-CT of the phantom has been acquired in cine mode, and reconstructed into ten phases with slice thickness 1.25 mm. The 4D images sets were imported into a treatment planning software for target contouring. The geometrical accuracy of the 4D MRI and CT images has been quantified using target volume, flattening, and eccentricity. The target motion was measured by tracking the centroids of the spheres in each individual phase. Motion ground-truth was obtained from input signals and real-time video recordings. Results: The dynamic phantom has been operated in four respiratory rate (RR) settings, 6, 10, 15, and 20/min, and was scanned with 4D-MRI and 4D-CT. 4D-CT images have target

  13. Improving Planck calibration by including frequency-dependent relativistic corrections

    SciTech Connect

    Quartin, Miguel; Notari, Alessio E-mail: notari@ffn.ub.es

    2015-09-01

    The Planck satellite detectors are calibrated in the 2015 release using the 'orbital dipole', which is the time-dependent dipole generated by the Doppler effect due to the motion of the satellite around the Sun. Such an effect has also relativistic time-dependent corrections of relative magnitude 10{sup −3}, due to coupling with the 'solar dipole' (the motion of the Sun compared to the CMB rest frame), which are included in the data calibration by the Planck collaboration. We point out that such corrections are subject to a frequency-dependent multiplicative factor. This factor differs from unity especially at the highest frequencies, relevant for the HFI instrument. Since currently Planck calibration errors are dominated by systematics, to the point that polarization data is currently unreliable at large scales, such a correction can in principle be highly relevant for future data releases.

  14. Spectator field models in light of spectral index after Planck

    SciTech Connect

    Kobayashi, Takeshi; Takahashi, Fuminobu; Takahashi, Tomo; Yamaguchi, Masahide E-mail: fumi@tuhep.phys.tohoku.ac.jp E-mail: gucci@phys.titech.ac.jp

    2013-10-01

    We revisit spectator field models including curvaton and modulated reheating scenarios, specifically focusing on their viability in the new Planck era, based on the derived expression for the spectral index in general spectator field models. Importantly, the recent Planck observations give strong preference to a red-tilted power spectrum, while the spectator field models tend to predict a scale-invariant one. This implies that, during inflation, either (i) the Hubble parameter varies significantly as in chaotic inflation, or (ii) a scalar potential for the spectator field has a relatively large negative curvature. Combined with the tight constraint on the non-Gaussianity, the Planck data provides us with rich implications for various spectator field models.

  15. Problems with the linear q-Fokker Planck equation

    NASA Astrophysics Data System (ADS)

    Yano, Ryosuke

    2015-05-01

    In this letter, we discuss the linear q-Fokker Planck equation, whose solution follows Tsallis distribution, from the viewpoint of kinetic theory. Using normal definitions of moments, we can expand the distribution function with infinite moments for 0 ⩽ q < 1, whereas we cannot expand the distribution function with infinite moments for 1 < q owing to emergences of characteristic points in moments. From Grad's 13 moment equations for the linear q-Fokker Planck equation, the dissipation rate of the heat flux via the linear q-Fokker Planck equation diverges at 0 ⩽ q < 2/3. In other words, the thermal conductivity, which defines the heat flux with the spatial gradient of the temperature and the thermal conductivity, which defines the heat flux with the spacial gradient of the density, jumps to zero at q = 2/3, discontinuously.

  16. Statistical measures of Planck scale signal correlations in interferometers

    SciTech Connect

    Hogan, Craig J.; Kwon, Ohkyung

    2015-06-22

    A model-independent statistical framework is presented to interpret data from systems where the mean time derivative of positional cross correlation between world lines, a measure of spreading in a quantum geometrical wave function, is measured with a precision smaller than the Planck time. The framework provides a general way to constrain possible departures from perfect independence of classical world lines, associated with Planck scale bounds on positional information. A parametrized candidate set of possible correlation functions is shown to be consistent with the known causal structure of the classical geometry measured by an apparatus, and the holographic scaling of information suggested by gravity. Frequency-domain power spectra are derived that can be compared with interferometer data. As a result, simple projections of sensitivity for specific experimental set-ups suggests that measurements will directly yield constraints on a universal time derivative of the correlation function, and thereby confirm or rule out a class of Planck scale departures from classical geometry.

  17. Improving Planck calibration by including frequency-dependent relativistic corrections

    NASA Astrophysics Data System (ADS)

    Quartin, Miguel; Notari, Alessio

    2015-09-01

    The Planck satellite detectors are calibrated in the 2015 release using the "orbital dipole", which is the time-dependent dipole generated by the Doppler effect due to the motion of the satellite around the Sun. Such an effect has also relativistic time-dependent corrections of relative magnitude 10-3, due to coupling with the "solar dipole" (the motion of the Sun compared to the CMB rest frame), which are included in the data calibration by the Planck collaboration. We point out that such corrections are subject to a frequency-dependent multiplicative factor. This factor differs from unity especially at the highest frequencies, relevant for the HFI instrument. Since currently Planck calibration errors are dominated by systematics, to the point that polarization data is currently unreliable at large scales, such a correction can in principle be highly relevant for future data releases.

  18. The role of semaphorin 4D in tumor development and angiogenesis in human breast cancer

    PubMed Central

    Jiang, Hongchao; Chen, Ceshi; Sun, Qiangming; Wu, Jing; Qiu, Lijuan; Gao, Change; Liu, Weiqing; Yang, Jun; Jun, Nie; Dong, Jian

    2016-01-01

    Background Semaphorin 4D (Sema4D) is highly expressed in certain types of tumors and functions in the regulation of tumor angiogenesis and growth. However, it is still not clear regarding the roles of Sema4D in breast cancer. This study was designed to explore the effects of Sema4D on proliferation, cell cycle progression, apoptosis, invasion, migration, tumor growth, and angiogenesis in breast cancer. Materials and methods The expression level of Sema4D was investigated in MCF10A, 184A1, HCC1937, MDA-MB-468, MDA-MB-231, Hs578T, BT474, MCF-7, and T47D breast cancer cell lines by Western blotting analysis. Sema4D downregulation or overexpression was established by infection with lentiviruses-encoding Sema4D short hairpin RNA (shRNA) or Sema4D. To evaluate the effects of Sema4D on cell proliferation, cell cycle progression, apoptosis, invasion, and migration of MDA-MB-231 and MDA-MB-468 cells, methods including MTT assay, flow cytometry, wound healing assay, and transwell experiments were applied. BALB/c nude mice were injected with MDA-MB-231 cells, which were respectively infected with lentiviruses-encoding Sema4D, Sema4D shRNA, and GFP, followed by tumor angiogenesis assay. Results Sema4D was expressed at higher levels in breast cancer cell lines compared with the normal human breast epithelial cell lines, especially in MDA-MB-231 and MDA-MB-468 cells. Cell proliferation ability was remarkably inhibited in Sema4D downregulated condition, whereas the proportions of cells in the G0/G1 phase and apoptosis increased in MDA-MB-231 and MDA-MB-468 cells. In addition, the invasion and migration abilities of these cells were obviously reduced. Xenograft growth as well as angiogenesis was inhibited when infected with lentiviruses-encoding Sema4D shRNA in vivo. Conclusion Downregulation of Sema4D had notable influence on cell proliferation ability, invasion, migration, and apoptosis of both MDA-MB-231 and MDA-MB-468 cells. Furthermore, infection with lentiviruses

  19. IMRT treatment planning on 4D geometries for the era of dynamic MLC tracking.

    PubMed

    Suh, Yelin; Murray, Walter; Keall, Paul J

    2014-12-01

    The problem addressed here was to obtain optimal and deliverable dynamic multileaf collimator (MLC) leaf sequences from four-dimensional (4D) geometries for dynamic MLC tracking delivery. The envisaged scenario was where respiratory phase and position information of the target was available during treatment, from which the optimal treatment plan could be further adapted in real time. A tool for 4D treatment plan optimization was developed that integrates a commercially available treatment planning system and a general-purpose optimization system. The 4D planning method was applied to the 4D computed tomography planning scans of three lung cancer patients. The optimization variables were MLC leaf positions as a function of monitor units and respiratory phase. The objective function was the deformable dose-summed 4D treatment plan score. MLC leaf motion was constrained by the maximum leaf velocity between control points in terms of monitor units for tumor motion parallel to the leaf travel direction and between phases for tumor motion parallel to the leaf travel direction. For comparison and a starting point for the 4D optimization, three-dimensional (3D) optimization was performed on each of the phases. The output of the 4D IMRT planning process is a leaf sequence which is a function of both monitor unit and phase, which can be delivered to a patient whose breathing may vary between the imaging and treatment sessions. The 4D treatment plan score improved during 4D optimization by 34%, 4%, and 50% for Patients A, B, and C, respectively, indicating 4D optimization generated a better 4D treatment plan than the deformable sum of individually optimized phase plans. The dose-volume histograms for each phase remained similar, indicating robustness of the 4D treatment plan to respiratory variations expected during treatment delivery. In summary, 4D optimization for respiratory phase-dependent treatment planning with dynamic MLC motion tracking improved the 4D treatment plan

  20. Self-unitarization of New Higgs Inflation and compatibility with Planck and BICEP2 data

    SciTech Connect

    Germani, Cristiano; Wintergerst, Nico; Watanabe, Yuki E-mail: watanabe@resceu.s.u-tokyo.ac.jp

    2014-12-01

    In this paper we show that the Germani-Kehagias model of Higgs inflation (or New Higgs Inflation), where the Higgs boson is kinetically non-minimally coupled to the Einstein tensor is in perfect compatibility with the latest Planck and BICEP2 data. Moreover, we show that the tension between the Planck and BICEP2 data can be relieved within the New Higgs inflation scenario by a negative running of the spectral index. Regarding the unitarity of the model, we argue that it is unitary throughout the evolution of the Universe. Weak couplings in the Higgs-Higgs and Higgs-graviton sectors are provided by a large background dependent cut-off scale during inflation. In the same regime, the W and Z gauge bosons acquire a very large mass, thus decouple. On the other hand, if they are also non-minimally coupled to the Higgs boson, their effective masses can be enormously reduced. In this case, the W and Z bosons are no longer decoupled. After inflation, the New Higgs model is well approximated by a quartic Galileon with a renormalizable potential. We argue that this can unitarily create the right conditions for inflation to eventually start.

  1. Planck Visualization Project: Seeing and Hearing the CMB

    NASA Astrophysics Data System (ADS)

    Van Der Veen, Jatila; Lubin, P. M.; 2; Alper, B.; 3; Smith, W.; 4; McGee, R.; 5; US Planck Collaboration

    2011-01-01

    The Planck Education and Public Outreach collaborators at the University of California, Santa Barbara and Purdue University have prepared a variety of materials to present the science goals of the Planck Mission to the public. Here we present our interactive simulation of the Cosmic Microwave Background, in which the user can change the ingredients of the universe and hear the different harmonics. We also present how we derive information about the early universe from the power spectrum of the CMB by using the physics of music for the public.

  2. Renormalization of transport equations in Fokker-Planck models

    NASA Astrophysics Data System (ADS)

    Grabert, Hermann; Weidlich, Wolfgang

    1980-06-01

    This paper is concerned with the derivation of nonlinear fluctuation-renormalized transport equations of a fluctuating thermodynamic system, on the assumption that the macroscopic variables defining a state undergo a Fokker-Planck process. It is shown that the renormalization effect may consist of two parts: a renormalization of the thermodynamic forces and a renormalization of the transport coefficients. Closed analytical expressions for the renormalized quantities in terms of the bare quantities appearing in the Fokker-Planck equation are derived. A scheme for the approximate evaluation of these expressions is given.

  3. Bounce-averaged Fokker-Planck code for stellarator transport

    SciTech Connect

    Mynick, H.E.; Hitchon, W.N.G.

    1985-07-01

    A computer code for solving the bounce-averaged Fokker-Planck equation appropriate to stellarator transport has been developed, and its first applications made. The code is much faster than the bounce-averaged Monte-Carlo codes, which up to now have provided the most efficient numerical means for studying stellarator transport. Moreover, because the connection to analytic kinetic theory of the Fokker-Planck approach is more direct than for the Monte-Carlo approach, a comparison of theory and numerical experiment is now possible at a considerably more detailed level than previously.

  4. A probe of Planck energy physics

    NASA Astrophysics Data System (ADS)

    Occhionero, F.

    } Mpc), homogeneity being restored thereabove. Another application of primordial bubbles is that they explain why, in apparent conflict with inflation, several authors claim that the Universe is open: it is sufficient that we live in a superhorizon bubble enucleated around N ~60 and that the Universe itself be a collection of such bubbles. Again a model based on FOG can be tuned to yield bubble spectra sharply peaked at Omega_0 .2, so that our probability of living in the right bubble is close to one. By unleashing one's fantasy, one can even envision a sequence of two phase transitions, at N ~60 and N ~50, where bubbles are born within bubbles and the bubbly topology and cosmogony are assigned to the open Universe. In conclusion, the study of the large scale structure may turn out to be a powerful probe -- and most likely the only one -- of Planck scale physics.

  5. 2D:4D digit ratio predicts delay of gratification in preschoolers.

    PubMed

    Da Silva, Sergio; Moreira, Bruno; Da Costa, Newton

    2014-01-01

    We replicate the Stanford marshmallow experiment with a sample of 141 preschoolers and find a correlation between lack of self-control and 2D:4D digit ratio. Children with low 2D:4D digit ratio are less likely to delay gratification. Low 2D:4D digit ratio may indicate high fetal testosterone. If this hypothesis is true, our finding means high fetal testosterone children are less likely to delay gratification.

  6. 2D:4D Digit Ratio Predicts Delay of Gratification in Preschoolers

    PubMed Central

    Da Silva, Sergio; Moreira, Bruno; Da Costa, Newton

    2014-01-01

    We replicate the Stanford marshmallow experiment with a sample of 141 preschoolers and find a correlation between lack of self-control and 2D:4D digit ratio. Children with low 2D:4D digit ratio are less likely to delay gratification. Low 2D:4D digit ratio may indicate high fetal testosterone. If this hypothesis is true, our finding means high fetal testosterone children are less likely to delay gratification. PMID:25490040

  7. Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis.

    PubMed

    Kaname, Tadashi; Ki, Chang-Seok; Niikawa, Norio; Baillie, George S; Day, Jonathan P; Yamamura, Ken-Ichi; Ohta, Tohru; Nishimura, Gen; Mastuura, Nobuo; Kim, Ok-Hwa; Sohn, Young Bae; Kim, Hyun Woo; Cho, Sung Yoon; Ko, Ah-Ra; Lee, Jin Young; Kim, Hyun Wook; Ryu, Sung Ho; Rhee, Hwanseok; Yang, Kap-Seok; Joo, Keehyoung; Lee, Jooyoung; Kim, Chi Hwa; Cho, Kwang-Hyun; Kim, Dongsan; Yanagi, Kumiko; Naritomi, Kenji; Yoshiura, Ko-Ichiro; Kondoh, Tatsuro; Nii, Eiji; Tonoki, Hidefumi; Houslay, Miles D; Jin, Dong-Kyu

    2014-11-01

    Acrodysostosis without hormone resistance is a rare skeletal disorder characterized by brachydactyly, nasal hypoplasia, mental retardation and occasionally developmental delay. Recently, loss-of-function mutations in the gene encoding cAMP-hydrolyzing phosphodiesterase-4D (PDE4D) have been reported to cause this rare condition but the pathomechanism has not been fully elucidated. To understand the pathogenetic mechanism of PDE4D mutations, we conducted 3D modeling studies to predict changes in the binding efficacy of cAMP to the catalytic pocket in PDE4D mutants. Our results indicated diminished enzyme activity in the two mutants we analyzed (Gly673Asp and Ile678Thr; based on PDE4D4 residue numbering). Ectopic expression of PDE4D mutants in HEK293 cells demonstrated this reduction in activity, which was identified by increased cAMP levels. However, the cells from an acrodysostosis patient showed low cAMP accumulation, which resulted in a decrease in the phosphorylated cAMP Response Element-Binding Protein (pCREB)/CREB ratio. The reason for this discrepancy was due to a compensatory increase in expression levels of PDE4A and PDE4B isoforms, which accounted for the paradoxical decrease in cAMP levels in the patient cells expressing mutant isoforms with a lowered PDE4D activity. Skeletal radiographs of 10-week-old knockout (KO) rats showed that the distal part of the forelimb was shorter than in wild-type (WT) rats and that all the metacarpals and phalanges were also shorter in KO, as the name acrodysostosis implies. Like the G-protein α-stimulatory subunit and PRKAR1A, PDE4D critically regulates the cAMP signal transduction pathway and influences bone formation in a way that activity-compromising PDE4D mutations can result in skeletal dysplasia. We propose that specific inhibitory PDE4D mutations can lead to the molecular pathology of acrodysostosis without hormone resistance but that the pathological phenotype may well be dependent on an over-compensatory induction

  8. 4D VMAT, gated VMAT, and 3D VMAT for stereotactic body radiation therapy in lung.

    PubMed

    Chin, E; Loewen, S K; Nichol, A; Otto, K

    2013-02-21

    Four-dimensional volumetric modulated arc therapy (4D VMAT) is a treatment strategy for lung cancers that aims to exploit relative target and tissue motion to improve organ at risk (OAR) sparing. The algorithm incorporates the entire patient respiratory cycle using 4D CT data into the optimization process. Resulting treatment plans synchronize the delivery of each beam aperture to a specific phase of target motion. Stereotactic body radiation therapy treatment plans for 4D VMAT, gated VMAT, and 3D VMAT were generated on three patients with non-small cell lung cancer. Tumour motion ranged from 1.4-3.4 cm. The dose and fractionation scheme was 48 Gy in four fractions. A B-spline transformation model registered the 4D CT images. 4D dose volume histograms (4D DVH) were calculated from total dose accumulated at the maximum exhalation. For the majority of OARs, gated VMAT achieved the most radiation sparing but treatment times were 77-148% longer than 3D VMAT. 4D VMAT plan qualities were comparable to gated VMAT, but treatment times were only 11-25% longer than 3D VMAT. 4D VMAT's improvement of healthy tissue sparing can allow for further dose escalation. Future study could potentially adapt 4D VMAT to irregular patient breathing patterns.

  9. A sinogram warping strategy for pre-reconstruction 4D PET optimization.

    PubMed

    Gianoli, Chiara; Riboldi, Marco; Fontana, Giulia; Kurz, Christopher; Parodi, Katia; Baroni, Guido

    2016-03-01

    A novel strategy for 4D PET optimization in the sinogram domain is proposed, aiming at motion model application before image reconstruction ("sinogram warping" strategy). Compared to state-of-the-art 4D-MLEM reconstruction, the proposed strategy is able to optimize the image SNR, avoiding iterative direct and inverse warping procedures, which are typical of the 4D-MLEM algorithm. A full-count statistics sinogram of the motion-compensated 4D PET reference phase is generated by warping the sinograms corresponding to the different PET phases. This is achieved relying on a motion model expressed in the sinogram domain. The strategy was tested on the anthropomorphic 4D PET-CT NCAT phantom in comparison with the 4D-MLEM algorithm, with particular reference to robustness to PET-CT co-registrations artefacts. The MLEM reconstruction of the warped sinogram according to the proposed strategy exhibited better accuracy (up to +40.90 % with respect to the ideal value), whereas images reconstructed according to the 4D-MLEM reconstruction resulted in less noisy (down to -26.90 % with respect to the ideal value) but more blurred. The sinogram warping strategy demonstrates advantages with respect to 4D-MLEM algorithm. These advantages are paid back by introducing approximation of the deformation field, and further efforts are required to mitigate the impact of such an approximation in clinical 4D PET reconstruction.

  10. 4D VMAT, gated VMAT, and 3D VMAT for stereotactic body radiation therapy in lung

    NASA Astrophysics Data System (ADS)

    Chin, E.; Loewen, S. K.; Nichol, A.; Otto, K.

    2013-02-01

    Four-dimensional volumetric modulated arc therapy (4D VMAT) is a treatment strategy for lung cancers that aims to exploit relative target and tissue motion to improve organ at risk (OAR) sparing. The algorithm incorporates the entire patient respiratory cycle using 4D CT data into the optimization process. Resulting treatment plans synchronize the delivery of each beam aperture to a specific phase of target motion. Stereotactic body radiation therapy treatment plans for 4D VMAT, gated VMAT, and 3D VMAT were generated on three patients with non-small cell lung cancer. Tumour motion ranged from 1.4-3.4 cm. The dose and fractionation scheme was 48 Gy in four fractions. A B-spline transformation model registered the 4D CT images. 4D dose volume histograms (4D DVH) were calculated from total dose accumulated at the maximum exhalation. For the majority of OARs, gated VMAT achieved the most radiation sparing but treatment times were 77-148% longer than 3D VMAT. 4D VMAT plan qualities were comparable to gated VMAT, but treatment times were only 11-25% longer than 3D VMAT. 4D VMAT's improvement of healthy tissue sparing can allow for further dose escalation. Future study could potentially adapt 4D VMAT to irregular patient breathing patterns.

  11. Unveiling hidden black holes in the cosmic web: Dark matter halos of WISE quasars from Planck CMB lensing

    NASA Astrophysics Data System (ADS)

    Hickox, Ryan

    The WISE and Planck surveys have now produced groundbreaking data sets which, in concert, can be exploited to obtain revolutionary constraints on the evolution of structure in the Universe. One particularly powerful application of WISE has been to uncover millions of the previously "hidden" obscured quasars, rapidly growing supermassive black holes that are shrouded in gas and dust and so are not detectable using traditional ground-based optical and near-IR techniques. Recently, Planck has produced the most precise all-sky map to date of dark matter structures via the lensing of the cosmic microwave background (CMB). We propose to combine these data sets to obtain a uniquely powerful measurement of the link between rapidly growing black holes and their host dark matter structures, by cross-correlating the density field of WISE-selected quasars with the CMB lensing convergence maps obtained from Planck. This proposal will build on our current ADAP program (NNX12AE38G), which studies the host dark matter halos of WISE-selected quasars via spatial clustering. NNX12AE38G involves a detailed characterization of the redshifts, luminosities, and spectral energy distributions of WISE-selected quasars and uses new techniques to measure how quasars cluster around themselves. NNX12AE38G has contributed to more than 10 journal articles and 5 conference proceedings. Building on our current work, an even more complete understanding of the link between black holes and their host dark matter structures is possible if we employ an independent method for measuring the clustering bias (and thus characteristic halo mass) of the quasar population. This has recently become possible using CMB lensing maps. In the past two years, our team has conducted an initial analysis covering 2500 square degrees using WISE-selected quasars and lensing maps from the South Pole Telescope (Geach, Hickox, Myers et al., 2013), and have implemented this technique with Planck over part of the SDSS region

  12. Eliminating the Gravitational Constant, G, and Improving SI Units, Using Two New Planck-Unit Frameworks With All Parameters as Ratios of Only H, C, and a

    NASA Astrophysics Data System (ADS)

    Lawrence, Michael

    2013-09-01

    This paper presents a tool kit of new ways of understanding fundamental physics and the relationships between parameters. The novel insights and predictions include: A self-contained consistent new Planck unit set of maximal-sized parameters from which all observed values can be compared and easily combined in equations. A self-contained consistent new Planck unit set of electroncharge-based parameters, some of which are directly observable in experiments. The interpretation of the gravitational constant, G as a dimensionless ratio eliminates the need to test the equivalence of gravitational and inertial mass. That all parameters can be displayed in terms of only h and c for the Planck maximal-parameter set and additionally in a for the electron-charge-based set, previously considered impossible. A new dimensional analysis employed to describe parameter dimensionality and to uncover any law of nature or universal constant. That all electron-charge-based Planck parameters can be described solely in terms of ratios of Rk and Kj and so will benefit from the precision of measurement of these two parameters. That most electromagnetic parameters can be reinterpreted in terms of mechanical parameters. By adjusting currently misaligned SI units to be self-consistent and consistent with these Double-adjusted-Planck units, greater clarity will ensue.

  13. Unveiling the Most Massive Clusters at z>0.5 with Planck and XMM-Newton

    NASA Astrophysics Data System (ADS)

    Mazzotta, Pasquale

    With this proposal, we request support for an approved XMM-Newton AO-11 (PI M. Arnaud, Co-I of this proposal) Large Programs that aim to study the physical properties of a sample of 33 massive (M_500>5 10e14 solar mass) clusters of galaxies blindly detected by Planck and confirmed to-day to be in the redshift range 0.5mass, high-redshift regime, we will study the fundamental scalings between YSZ, YX, and M500, and the pressure and entropy profiles. To reach this purpose we requested the observation of 25 systems that, to date, did not have sufficient X-ray exposure or no X-ray data at all. The XMM Newton Observing Time Allocation Committee awarded us to observe all the proposed targets for a total exposure time of 595 ks. Based on other work carried out as part of Planck catalog validation, we know that all the clusters in the sample are hot (kT >5keV), high mass objects with complex morphologies and density profiles far shallower than those of X-ray-selected cluster samples in the same mass range. Our study will help addressing fundamental questions in the field like the structure formation in the Universe and the physics of the intracluster medium. In particular, we will be able to constraining, for the first time, the SZ-X-ray-Optical scaling relations of a unique and statistically significant sample of cluster of galaxies in the high mass high z (0.5Planck cluster sample that will be made available to the scientific community in the next few years.

  14. A fully non-linear multi-species Fokker-Planck-Landau collision operator for simulation of fusion plasma

    NASA Astrophysics Data System (ADS)

    Hager, Robert; Yoon, E. S.; Ku, S.; D'Azevedo, E. F.; Worley, P. H.; Chang, C. S.

    2016-06-01

    Fusion edge plasmas can be far from thermal equilibrium and require the use of a non-linear collision operator for accurate numerical simulations. In this article, the non-linear single-species Fokker-Planck-Landau collision operator developed by Yoon and Chang (2014) [9] is generalized to include multiple particle species. The finite volume discretization used in this work naturally yields exact conservation of mass, momentum, and energy. The implementation of this new non-linear Fokker-Planck-Landau operator in the gyrokinetic particle-in-cell codes XGC1 and XGCa is described and results of a verification study are discussed. Finally, the numerical techniques that make our non-linear collision operator viable on high-performance computing systems are described, including specialized load balancing algorithms and nested OpenMP parallelization. The collision operator's good weak and strong scaling behavior are shown.

  15. Tumor and normal tissue motion in the thorax during respiration: Analysis of volumetric and positional variations using 4D CT

    SciTech Connect

    Weiss, Elisabeth . E-mail: eweiss@mcvh-vcu.edu; Wijesooriya, Krishni; Dill, S. Vaughn; Keall, Paul J.

    2007-01-01

    Purpose: To investigate temporospatial variations of tumor and normal tissue during respiration in lung cancer patients. Methods and Materials: In 14 patients, gross tumor volume (GTV) and normal tissue structures were manually contoured on four-dimensional computed tomography (4D-CT) scans. Structures were evaluated for volume changes, centroid (center of mass) motion, and phase dependence of variations relative to inspiration. Only volumetrically complete structures were used for analysis (lung in 2, heart in 8, all other structures in >10 patients). Results: During respiration, the magnitude of contoured volumes varied up to 62.5% for GTVs, 25.5% for lungs, and 12.6% for hearts. The range of maximum three-dimensional centroid movement for individual patients was 1.3-24.0 mm for GTV, 2.4-7.9 mm for heart, 5.2-12.0 mm for lungs, 0.3-5.5 mm for skin markers, 2.9-10.0 mm for trachea, and 6.6-21.7 mm for diaphragm. During respiration, the centroid positions of normal structures varied relative to the centroid position of the respective GTV by 1.5-8.1 mm for heart, 2.9-9.3 mm for lungs, 1.2-9.2 mm for skin markers, 0.9-7.1 mm for trachea, and 2.7-16.4 mm for diaphragm. Conclusion: Using 4D-CT, volumetric changes, positional alterations as well as changes in the position of contoured structures relative to the GTV were observed with large variations between individual patients. Although the interpretation of 4D-CT data has considerable uncertainty because of 4D-CT artifacts, observer variations, and the limited acquisition time, the findings might have a significant impact on treatment planning.

  16. Preliminary Clinical Evaluation of a 4D-CBCT Estimation Technique using Prior Information and Limited-angle Projections

    PubMed Central

    Zhang, You; Yin, Fang-Fang; Pan, Tinsu; Vergalasova, Irina; Ren, Lei

    2015-01-01

    Background and Purpose A new technique has been previously reported to estimate high-quality 4D-CBCT using prior information and limited-angle projections. This study is to investigate its clinical feasibility through both phantom and patient studies. Materials and Methods The new technique used to estimate 4D-CBCT is called MMFD-NCC. It is based on the previously reported motion-modeling and free-form deformation (MMFD) method, with the introduction of normalized-cross-correlation (NCC) as a new similarity metric. The clinical feasibility of this technique was evaluated by assessing the accuracy of estimated anatomical structures in comparison to those in the ‘ground-truth’ reference 4D-CBCT, using data obtained from a physical phantom and three lung cancer patients. Both volume percentage error (VPE) and center-of-mass error (COME) of the estimated tumor volume were used as the evaluation metrics. Results The average VPE/COME of the tumor in the prior image was 257.1%/10.1 mm for the phantom study and 55.6%/3.8 mm for the patient study. Using only orthogonal-view 30° projections, the MMFD-NCC has reduced the corresponding values to 7.7% /1.2 mm and 9.6%/1.1 mm, respectively. Conclusions The MMFD-NCC technique is able to estimate 4D-CBCT images with geometrical accuracy of the tumor within 10% VPE and 2 mm COME, which can be used to improve the localization accuracy of radiotherapy. PMID:25818396

  17. Excess B-modes extracted from the Planck polarization maps

    NASA Astrophysics Data System (ADS)

    Nørgaard-Nielsen, H. U.

    2016-07-01

    One of the main obstacles for extracting the Cosmic Microwave Background (CMB) from mm/submm observations is the pollution from the main Galactic components: synchrotron, free-free and thermal dust emission. The feasibility of using simple neural networks to extract CMB has been demonstrated on both temperature and polarization data obtained by the WMAP satellite. The main goal of this paper is to demonstrate the feasibility of neural networks for extracting the CMB signal from the Planck polarization data with high precision. Both auto-correlation and cross-correlation power spectra within a mask covering about 63 % of the sky have been used together with a ``high pass filter'' in order to minimize the influence of the remaining systematic errors in the Planck Q and U maps. Using the Planck 2015 released polarization maps, a BB power spectrum have been extracted by Multilayer Perceptron neural networks. This spectrum contains a bright feature with signal to noise ratios ≃ 4.5 within 200 ≤ l ≤ 250. The spectrum is significantly brighter than the BICEP2 2015 spectrum, with a spectral behaviour quite different from the ``canonical'' models (weak lensing plus B-modes spectra with different tensor to scalar ratios). The feasibility of the neural network to remove the residual systematics from the available Planck polarization data to a high level has been demonstrated.

  18. Planck's radiation law: is a quantum-classical perspective possible?

    NASA Astrophysics Data System (ADS)

    Marrocco, Michele

    2016-05-01

    Planck's radiation law provides the solution to the blackbody problem that marks the decline of classical physics and the rise of the quantum theory of the radiation field. Here, we venture to suggest the possibility that classical physics might be equally suitable to deal with the blackbody problem. A classical version of the Planck's radiation law seems to be achievable if we learn from the quantum-classical correspondence between classical Mie theory and quantum-mechanical wave scattering from spherical scatterers (partial wave analysis). This correspondence designs a procedure for countable energy levels of the radiation trapped within the blackbody treated within the multipole approach of classical electrodynamics (in place of the customary and problematic expansion in terms of plane waves that give rise to the ultraviolet catastrophe). In turn, introducing the Boltzmann discretization of energy levels, the tools of classical thermodynamics and statistical theory become available for the task. On the other hand, the final result depends on a free parameter whose physical units are those of an action. Tuning this parameter on the value given by the Planck constant makes the classical result agree with the canonical Planck's radiation law.

  19. Cosmological texture is incompatible with Planck-scale physics

    NASA Technical Reports Server (NTRS)

    Holman, Richard; Hsu, Stephen D. H.; Kolb, Edward W.; Watkins, Richard; Widrow, Lawrence M.

    1992-01-01

    Nambu-Goldstone modes are sensitive to the effects of physics at energies comparable to the scale of spontaneous symmetry breaking. We show that as a consequence of this the global texture proposal for structure formation requires rather severe assumptions about the nature of physics at the Planck scale.

  20. Planck 2015 results. I. Overview of products and scientific results

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Adam, R.; Ade, P. A. R.; Aghanim, N.; Akrami, Y.; Alves, M. I. R.; Argüeso, F.; Arnaud, M.; Arroja, F.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Ballardini, M.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Bartolo, N.; Basak, S.; Battaglia, P.; Battaner, E.; Battye, R.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bertincourt, B.; Bielewicz, P.; Bikmaev, I.; Bock, J. J.; Böhringer, H.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burenin, R.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Carvalho, P.; Casaponsa, B.; Castex, G.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chiang, H. C.; Chluba, J.; Chon, G.; Christensen, P. R.; Church, S.; Clemens, M.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Comis, B.; Contreras, D.; Couchot, F.; Coulais, A.; Crill, B. P.; Cruz, M.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Di Valentino, E.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Eisenhardt, P. R. M.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Falgarone, E.; Fantaye, Y.; Farhang, M.; Feeney, S.; Fergusson, J.; Fernandez-Cobos, R.; Feroz, F.; Finelli, F.; Florido, E.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschet, C.; Franceschi, E.; Frejsel, A.; Frolov, A.; Galeotta, S.; Galli, S.; Ganga, K.; Gauthier, C.; Génova-Santos, R. T.; Gerbino, M.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Giusarma, E.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Grainge, K. J. B.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hamann, J.; Handley, W.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Heavens, A.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huang, Z.; Huffenberger, K. M.; Hurier, G.; Ilić, S.; Jaffe, A. H.; Jaffe, T. R.; Jin, T.; Jones, W. C.; Juvela, M.; Karakci, A.; Keihänen, E.; Keskitalo, R.; Khamitov, I.; Kiiveri, K.; Kim, J.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Krachmalnicoff, N.; Kunz, M.; Kurki-Suonio, H.; Lacasa, F.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Langer, M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Le Jeune, M.; Leahy, J. P.; Lellouch, E.; Leonardi, R.; León-Tavares, J.; Lesgourgues, J.; Levrier, F.; Lewis, A.; Liguori, M.; Lilje, P. B.; Lilley, M.; Linden-Vørnle, M.; Lindholm, V.; Liu, H.; López-Caniego, M.; Lubin, P. M.; Ma, Y.-Z.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mak, D. S. Y.; Mandolesi, N.; Mangilli, A.; Marchini, A.; Marcos-Caballero, A.; Marinucci, D.; Maris, M.; Marshall, D. J.; Martin, P. G.; Martinelli, M.; Martínez-González, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; McEwen, J. D.; McGehee, P.; Mei, S.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mikkelsen, K.; Millea, M.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Moreno, R.; Morgante, G.; Mortlock, D.; Moss, A.; Mottet, S.; Münchmeyer, M.; Munshi, D.; Murphy, J. A.; Narimani, A.; Naselsky, P.; Nastasi, A.; Nati, F.; Natoli, P.; Negrello, M.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Olamaie, M.; Oppermann, N.; Orlando, E.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Pandolfi, S.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Peel, M.; Peiris, H. V.; Pelkonen, V.-M.; Perdereau, O.; Perotto, L.; Perrott, Y. C.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pogosyan, D.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Racine, B.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Roman, M.; Romelli, E.; Rosset, C.; Rossetti, M.; Rotti, A.; Roudier, G.; Rouillé d'Orfeuil, B.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Ruiz-Granados, B.; Rumsey, C.; Rusholme, B.; Said, N.; Salvatelli, V.; Salvati, L.; Sandri, M.; Sanghera, H. S.; Santos, D.; Saunders, R. D. E.; Sauvé, A.; Savelainen, M.; Savini, G.; Schaefer, B. M.; Schammel, M. P.; Scott, D.; Seiffert, M. D.; Serra, P.; Shellard, E. P. S.; Shimwell, T. W.; Shiraishi, M.; Smith, K.; Souradeep, T.; Spencer, L. D.; Spinelli, M.; Stanford, S. A.; Stern, D.; Stolyarov, V.; Stompor, R.; Strong, A. W.; Sudiwala, R.; Sunyaev, R.; Sutter, P.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Tavagnacco, D.; Terenzi, L.; Texier, D.; Toffolatti, L.; Tomasi, M.; Tornikoski, M.; Tramonte, D.; Tristram, M.; Troja, A.; Trombetti, T.; Tucci, M.; Tuovinen, J.; Türler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, F.; Vassallo, T.; Vibert, L.; Vidal, M.; Viel, M.; Vielva, P.; Villa, F.; Wade, L. A.; Walter, B.; Wandelt, B. D.; Watson, R.; Wehus, I. K.; Welikala, N.; Weller, J.; White, M.; White, S. D. M.; Wilkinson, A.; Yvon, D.; Zacchei, A.; Zibin, J. P.; Zonca, A.

    2016-09-01

    The European Space Agency's Planck satellite, which is dedicated to studying the early Universe and its subsequent evolution, was launched on 14 May 2009. It scanned the microwave and submillimetre sky continuously between 12 August 2009 and 23 October 2013. In February 2015, ESA and the Planck Collaboration released the second set of cosmology products based ondata from the entire Planck mission, including both temperature and polarization, along with a set of scientific and technical papers and a web-based explanatory supplement. This paper gives an overview of the main characteristics of the data and the data products in the release, as well as the associated cosmological and astrophysical science results and papers. The data products include maps of the cosmic microwave background (CMB), the thermal Sunyaev-Zeldovich effect, diffuse foregrounds in temperature and polarization, catalogues of compact Galactic and extragalactic sources (including separate catalogues of Sunyaev-Zeldovich clusters and Galactic cold clumps), and extensive simulations of signals and noise used in assessing uncertainties and the performance of the analysis methods. The likelihood code used to assess cosmological models against the Planck data is described, along with a CMB lensing likelihood. Scientific results include cosmological parameters derived from CMB power spectra, gravitational lensing, and cluster counts, as well as constraints on inflation, non-Gaussianity, primordial magnetic fields, dark energy, and modified gravity, and new results on low-frequency Galactic foregrounds.

  1. Fokker-Planck transport in solid state accelerator concepts

    SciTech Connect

    Newberger, B.; Tajima, T.

    1989-01-01

    Particle transport in a crystalline solid under channeling conditions is considered by means of a Fokker-Planck description. The model includes electron multiple scattering, radiation damping and an accelerating electric field. Analytic solutions have been obtained using a harmonic potential model to describe the channeling forces. These solutions will be described.

  2. Teaching Tip: Managing Software Engineering Student Teams Using Pellerin's 4-D System

    ERIC Educational Resources Information Center

    Doman, Marguerite; Besmer, Andrew; Olsen, Anne

    2015-01-01

    In this article, we discuss the use of Pellerin's Four Dimension Leadership System (4-D) as a way to manage teams in a classroom setting. Over a 5-year period, we used a modified version of the 4-D model to manage teams within a senior level Software Engineering capstone course. We found that this approach for team management in a classroom…

  3. Elite collegiate tennis athletes have lower 2D: 4D ratios than those of nonathlete controls.

    PubMed

    Hsu, Cheng-Chen; Su, Borcherng; Kan, Nai-Wen; Lai, Su-Ling; Fong, Tsorng-Harn; Chi, Chung-Pu; Chang, Ching-Chyuan; Hsu, Mei-Chich

    2015-03-01

    The ratio of the length of the second finger (index finger) to the fourth finger (ring finger) (2D:4D ratio) is a putative marker for prenatal hormones. Physiological research has suggested a low 2D:4D ratio correlates with high athletic ability. Athletes of specific sports (e.g., American football) have lower 2D:4D ratios than those of nonathletes, whereas athletes of some sports (e.g., rowing, gymnastics, and soccer) do not. This study investigated the 2D:4D ratios among collegiate tennis athletes, elite collegiate tennis athletes, and nonelite collegiate tennis athletes and compared them with nonathletes of both sexes. The participants included 43 elite collegiate tennis athletes (Level I intercollegiate athletes in Taiwan; 27 males and 16 females), 107 nonelite collegiate tennis athletes (Level II athletes; 55 males and 52 females), and 166 nonathlete college students (80 males and 86 females). The principle findings suggest that (a) regardless of sex, collegiate tennis athletes have lower 2D:4D values than those of nonathletes; (b) elite collegiate tennis athletes have lower 2D:4D values than those of nonathletes; (c) among females but not males, athletes and nonelite athletes have lower 2D:4D values than those of nonathletes; and (d) males have lower 2D:4D values than those of females. PMID:25226321

  4. Elite collegiate tennis athletes have lower 2D: 4D ratios than those of nonathlete controls.

    PubMed

    Hsu, Cheng-Chen; Su, Borcherng; Kan, Nai-Wen; Lai, Su-Ling; Fong, Tsorng-Harn; Chi, Chung-Pu; Chang, Ching-Chyuan; Hsu, Mei-Chich

    2015-03-01

    The ratio of the length of the second finger (index finger) to the fourth finger (ring finger) (2D:4D ratio) is a putative marker for prenatal hormones. Physiological research has suggested a low 2D:4D ratio correlates with high athletic ability. Athletes of specific sports (e.g., American football) have lower 2D:4D ratios than those of nonathletes, whereas athletes of some sports (e.g., rowing, gymnastics, and soccer) do not. This study investigated the 2D:4D ratios among collegiate tennis athletes, elite collegiate tennis athletes, and nonelite collegiate tennis athletes and compared them with nonathletes of both sexes. The participants included 43 elite collegiate tennis athletes (Level I intercollegiate athletes in Taiwan; 27 males and 16 females), 107 nonelite collegiate tennis athletes (Level II athletes; 55 males and 52 females), and 166 nonathlete college students (80 males and 86 females). The principle findings suggest that (a) regardless of sex, collegiate tennis athletes have lower 2D:4D values than those of nonathletes; (b) elite collegiate tennis athletes have lower 2D:4D values than those of nonathletes; (c) among females but not males, athletes and nonelite athletes have lower 2D:4D values than those of nonathletes; and (d) males have lower 2D:4D values than those of females.

  5. Cold or warm? Constraining dark matter with primeval galaxies and cosmic reionization after Planck

    NASA Astrophysics Data System (ADS)

    Lapi, A.; Danese, L.

    2015-09-01

    Dark matter constitutes the great majority of the matter content in the Universe, but its microscopic nature remains an intriguing mystery, with profound implications for particle physics, astrophysics and cosmology. Here we shed light on the longstanding issue of whether the dark matter is warm or cold by combining the measurements of the galaxy luminosity functions out to high redshifts 0z~ 1 from the Hubble Space Telescope with the recent cosmological data on the reionization history of the Universe from the Planck mission. We derive robust and tight bounds on the mass of warm dark matter particle, finding that the current data require it to be in the narrow range between 2 and 3 keV . In addition, we show that a mass not exceeding 3 keV is also concurrently indicated by astrophysical constraints related to the local number of satellites in Milky Way-sized galaxies, though it is in marginal tension with analysis of the Lyman-α forest. For warm dark matter masses above 3 keV as well as for cold dark matter, to satisfy the Planck constraints on the optical depth and not to run into the satellite problem would require invoking astrophysical processes that inhibit galaxy formation in halos with mass MH lesssim few × 10 8 Msolar, corresponding to a limiting UV magnitude MUV≈ -11. Anyway, we predict a downturn of the galaxy luminosity function at z~ 8 faintward of MUV≈ -12, and stress that its detailed shape is extremely informative both on particle physics and on the astrophysics of galaxy formation in small halos. These expectations will be tested via the Hubble Frontier Fields and with the advent of the James Webb Space Telescope, which will enable probing the very faint end of the galaxy luminosity function out to z ~ 8-10.

  6. The Influence of Facial Characteristics on the Relation between Male 2D:4D and Dominance

    PubMed Central

    Ryckmans, Jan; Millet, Kobe; Warlop, Luk

    2015-01-01

    Although relations between 2D:4D and dominance rank in both baboons and rhesus macaques have been observed, evidence in humans is mixed. Whereas behavioral patterns in humans have been discovered that are consistent with these animal findings, the evidence for a relation between dominance and 2D:4D is weak or inconsistent. The present study provides experimental evidence that male 2D:4D is related to dominance after (fictitious) male-male interaction when the other man has a dominant, but not a submissive or neutral face. This finding provides evidence that the relationship between 2D:4D and dominance emerges in particular, predictable situations and that merely dominant facial characteristics of another person are enough to activate supposed relationships between 2D:4D and dominance. PMID:26600255

  7. Simultaneous motion estimation and image reconstruction (SMEIR) for 4D cone-beam CT

    SciTech Connect

    Wang, Jing; Gu, Xuejun

    2013-10-15

    Purpose: Image reconstruction and motion model estimation in four-dimensional cone-beam CT (4D-CBCT) are conventionally handled as two sequential steps. Due to the limited number of projections at each phase, the image quality of 4D-CBCT is degraded by view aliasing artifacts, and the accuracy of subsequent motion modeling is decreased by the inferior 4D-CBCT. The objective of this work is to enhance both the image quality of 4D-CBCT and the accuracy of motion model estimation with a novel strategy enabling simultaneous motion estimation and image reconstruction (SMEIR).Methods: The proposed SMEIR algorithm consists of two alternating steps: (1) model-based iterative image reconstruction to obtain a motion-compensated primary CBCT (m-pCBCT) and (2) motion model estimation to obtain an optimal set of deformation vector fields (DVFs) between the m-pCBCT and other 4D-CBCT phases. The motion-compensated image reconstruction is based on the simultaneous algebraic reconstruction technique (SART) coupled with total variation minimization. During the forward- and backprojection of SART, measured projections from an entire set of 4D-CBCT are used for reconstruction of the m-pCBCT by utilizing the updated DVF. The DVF is estimated by matching the forward projection of the deformed m-pCBCT and measured projections of other phases of 4D-CBCT. The performance of the SMEIR algorithm is quantitatively evaluated on a 4D NCAT phantom. The quality of reconstructed 4D images and the accuracy of tumor motion trajectory are assessed by comparing with those resulting from conventional sequential 4D-CBCT reconstructions (FDK and total variation minimization) and motion estimation (demons algorithm). The performance of the SMEIR algorithm is further evaluated by reconstructing a lung cancer patient 4D-CBCT.Results: Image quality of 4D-CBCT is greatly improved by the SMEIR algorithm in both phantom and patient studies. When all projections are used to reconstruct a 3D-CBCT by FDK, motion

  8. Interpreting digit ratio (2D:4D)-behavior correlations: 2D:4D sex difference, stability, and behavioral correlates and their replicability in young children.

    PubMed

    Wong, Wang I; Hines, Melissa

    2016-02-01

    The popularity of using the ratio of the second to the fourth digit (2D:4D) to study influences of early androgen exposure on human behavior relies, in part, on a report that the ratio is sex-dimorphic and stable from age 2 years (Manning etal., 1998). However, subsequent research has rarely replicated this finding. Moreover, although 2D:4D has been correlated with many behaviors, these correlations are often inconsistent. Young children's 2D:4D-behavior correlations may be more consistent than those of older individuals, because young children have experienced fewer postnatal influences. To evaluate the usefulness of 2D:4D as a biomarker of prenatal androgen exposure in studies of 2D:4D-behavior correlations, we assessed its sex difference, temporal stability, and behavioral correlates over a 6- to 8-month period in 126, 2- to 3-year-old children, providing a rare same-sample replicability test. We found a moderate sex difference on both hands and high temporal stability. However, between-sex overlap and within-sex variability were also large. Only 3 of 24 correlations with sex-typed behaviors-scores on the Preschool Activities Inventory (PSAI), preference for a boy-typical toy, preference for a girl-typical toy, were significant and in the predicted direction, all of which involved the PSAI, partially confirming findings from another study. Correlation coefficients were larger for behaviors that showed larger sex differences. But, as in older samples, the overall pattern showed inconsistency across time, sex, and hand. Therefore, although sex-dimorphic and stable, 2D:4D-behavior correlations are no more consistent for young children than for older samples. Theoretical and methodological implications are discussed.

  9. Planck 2013 results. XXI. Power spectrum and high-order statistics of the Planck all-sky Compton parameter map

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bobin, J.; Bock, J. J.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bridges, M.; Bucher, M.; Burigana, C.; Butler, R. C.; Cardoso, J.-F.; Carvalho, P.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Chiang, L.-Y.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Comis, B.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Da Silva, A.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Dupac, X.; Efstathiou, G.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Flores-Cacho, I.; Forni, O.; Frailis, M.; Franceschi, E.; Galeotta, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Giardino, G.; Giraud-Héraud, Y.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Hanson, D.; Harrison, D.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lacasa, F.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Laureijs, R. J.; Lawrence, C. R.; Leahy, J. P.; Leonardi, R.; León-Tavares, J.; Lesgourgues, J.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Marcos-Caballero, A.; Maris, M.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Osborne, S.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Starck, J.-L.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sureau, F.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Tavagnacco, D.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Varis, J.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; White, S. D. M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2014-11-01

    We have constructed the first all-sky map of the thermal Sunyaev-Zeldovich (tSZ) effect by applying specifically tailored component separation algorithms to the 100 to 857 GHz frequency channel maps from the Planck survey. This map shows an obvious galaxy cluster tSZ signal that is well matched with blindly detected clusters in the Planck SZ catalogue. To characterize the signal in the tSZ map we have computed its angular power spectrum. At large angular scales (ℓ < 60), the major foreground contaminant is the diffuse thermal dust emission. At small angular scales (ℓ > 500) the clustered cosmic infrared background and residual point sources are the major contaminants. These foregrounds are carefully modelled and subtracted. We thus measure the tSZ power spectrum over angular scales 0.17° ≲ θ ≲ 3.0° that were previously unexplored. The measured tSZ power spectrum is consistent with that expected from the Planck catalogue of SZ sources, with clear evidence of additional signal from unresolved clusters and, potentially, diffuse warm baryons. Marginalized band-powers of the Planck tSZ power spectrum and the best-fit model are given. The non-Gaussianity of the Compton parameter map is further characterized by computing its 1D probability distribution function and its bispectrum. The measured tSZ power spectrum and high order statistics are used to place constraints on σ8.

  10. Fokker-Planck model for collisional loss of fast ions in tokamaks

    NASA Astrophysics Data System (ADS)

    Yavorskij, V.; Goloborod'ko, V.; Schoepf, K.

    2016-11-01

    Modelling of the collisional loss of fast ions from tokamak plasmas is important from the point of view of the impact of fusion alphas and neutral beam injection ions on plasma facing components as well as for the development of diagnostics of fast ion losses [1-3]. This paper develops a Fokker-Planck (FP) method for the assessment of distributions of collisional loss of fast ions as depending on the coordinates of the first wall surface and on the velocities of lost ions. It is shown that the complete 4D drift FP approach for description of fast ions in axisymmetric tokamak plasmas can be reduced to a 2D FP problem for lost ions with a boundary condition delivered by the solution of a 3D boundary value problem for confined ions. Based on this newly developed FP approach the poloidal distribution of neoclassical loss, depending on pitch-angle and energy, of fast ions from tokamak plasma may be examined as well as the contribution of this loss to the signal detected by the scintillator probe may be evaluated. It is pointed out that the loss distributions obtained with the novel FP treatment may serve as an alternative approach with respect to Monte-Carlo models [4, 5] commonly used for simulating fast ion loss from toroidal plasmas.

  11. Weight of the evidence on the human carcinogenicity of 2,4-D*

    PubMed Central

    Ibrahim, M. A.; Bond, G. G.; Burke, T. A.; Cole, P.; Dost, F. N.; Enterline, P. E.; Gough, M.; Greenberg, R. S.; Halperin, W. E.; McConnell, E.; Munro, I. C.; Swenberg, J. A.; Zahm, S. H.; Graham, J. D.

    1991-01-01

    The phenoxy herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used to control the growth of weeds and broadleaf plants. We convened a panel of 13 scientists to weigh the evidence on the human carcinogenicity of 2,4-D. The panel based its findings on a review of the toxicological and epidemiological literature on 2,4-D and related phenoxy herbicides. The toxicological data do not provide a strong basis for predicting that 2,4-D is a human carcinogen. Although a cause–effect relationship is far from being established, the epidemiological evidence for an association between exposure to 2,4-D and non–Hodgkin's lymphoma is suggestive and requires further investigation. There is little evidence of an association between use of 2,4-D and soft-tissue sarcoma or Hodgkin's disease, and no evidence of an association between 2,4-D use and any other form of cancer. Scientists on the panel were asked to categorize 2,4-D as a “known,” “probable,” “possible,” or “unlikely” carcinogen or as a noncarcinogen in humans. The predominant opinion among the panel members was that the weight of the evidence indicates that it is possible that exposure to 2,4-D can cause cancer in humans, although not all of the panelists believed the possibility was equally likely: one thought the possibility was strong, leaning toward probable, and five thought the possibility was remote, leaning toward unlikely. Two panelists believed it unlikely that 2,4-D can cause cancer in humans. PMID:1820267

  12. Serum Soluble Semaphorin 4D is Associated with Left Atrial Diameter in Patients with Atrial Fibrillation

    PubMed Central

    Xiang, Li; You, Tao; Chen, Jianchang; Xu, Weiting; Jiao, Yang

    2015-01-01

    Background The aim of this study was to evaluate the serum soluble semaphorin 4D (sSema4D) in patients with atrial fibrillation and to investigate the relationship of serum sSema4D with left atrial diameter (LAD). Material/Methods We studied a total of 113 patients who were subdivided into paroxysmal and non-paroxysmal (included persistent and permanent) atrial fibrillation groups, respectively. Another 55 subjects without atrial fibrillation were enrolled as the healthy control group. Serum levels of soluble semaphorin 4D (Sema4D) were measured in all subjects using the enzyme-labeled immunosorbent assay method. We also evaluated the coagulation parameters and left atrial diameters. Results Patients with paroxysmal and non-paroxysmal atrial fibrillation had significantly higher sSema4D level compared with controls (8.50±2.19 ng/mL and 9.30±2.28 ng/mL vs. 6.56±1.27 ng/ml, P<0.05). Serum sSema4D concentrations were elevated in patients with non-paroxysmal atrial fibrillation compared to those with paroxysmal atrial fibrillation (P<0.001). The level of sSema4D was positively correlated with LAD (r=0.606, P<0.001). Multivariate logistic regression analysis revealed that serum sSema4D, LAD, male sex, heart rate, hypertension, and coronary artery disease were associated with atrial fibrillation (P<0.05). Conclusions Serum sSema4D levels are increased in patients with atrial fibrillation and are independently associated with atrial remodeling. PMID:26417899

  13. TU-C-BRD-01: Image Guided SBRT I: Multi-Modality 4D Imaging

    SciTech Connect

    Cai, J; Mageras, G; Pan, T

    2014-06-15

    Motion management is one of the critical technical challenges for radiation therapy. 4D imaging has been rapidly adopted as essential tool to assess organ motion associated with respiratory breathing. A variety of 4D imaging techniques have been developed and are currently under development based on different imaging modalities such as CT, MRI, PET, and CBCT. Each modality provides specific and complementary information about organ and tumor respiratory motion. Effective use of each different technique or combined use of different techniques can introduce a comprehensive management of tumor motion. Specifically, these techniques have afforded tremendous opportunities to better define and delineate tumor volumes, more accurately perform patient positioning, and effectively apply highly conformal therapy techniques such as IMRT and SBRT. Successful implementation requires good understanding of not only each technique, including unique features, limitations, artifacts, imaging acquisition and process, but also how to systematically apply the information obtained from different imaging modalities using proper tools such as deformable image registration. Furthermore, it is important to understand the differences in the effects of breathing variation between different imaging modalities. A comprehensive motion management strategy using multi-modality 4D imaging has shown promise in improving patient care, but at the same time faces significant challenges. This session will focuses on the current status and advances in imaging respiration-induced organ motion with different imaging modalities: 4D-CT, 4D-MRI, 4D-PET, and 4D-CBCT/DTS. Learning Objectives: Understand the need and role of multimodality 4D imaging in radiation therapy. Understand the underlying physics behind each 4D imaging technique. Recognize the advantages and limitations of each 4D imaging technique.

  14. Cold dark matter haloes in the Planck era: evolution of structural parameters for Einasto and NFW profiles

    NASA Astrophysics Data System (ADS)

    Dutton, Aaron A.; Macciò, Andrea V.

    2014-07-01

    We present the evolution of the structure of relaxed cold dark matter (CDM) haloes in the cosmology from the Planck satellite. Our simulations cover five decades in halo mass, from dwarf galaxies to galaxy clusters. Because of the increased matter density and power spectrum normalization the concentration-mass relation in the Planck cosmology has a ˜20 per cent higher normalization at redshift z = 0 compared to Wilkinson Microwave Anisotropy Probe cosmology. We confirm that CDM haloes are better described by the Einasto profile; for example, at scales near galaxy half-light radii CDM haloes have significantly steeper density profiles than implied by Navarro-Frenk-White (NFW) fits. There is a scatter of ˜0.2 dex in the Einasto shape parameter at fixed halo mass, adding further to the diversity of CDM halo profiles. The evolution of the concentration-mass relation in our simulations is not reproduced by any of the analytic models in the literature. We thus provide a simple fitting formula that accurately describes the evolution between redshifts z = 5 and 0 for both NFW and Einasto fits. Finally, the observed concentrations and halo masses of spiral galaxies, groups and clusters of galaxies at low redshifts are in good agreement with our simulations, suggesting only mild halo response to galaxy formation on these scales.

  15. Four-dimensional (4D) PET/CT imaging of the thorax

    SciTech Connect

    Nehmeh, S.A.; Erdi, Y.E.; Pan, T.

    2004-12-01

    We have reported in our previous studies on the methodology, and feasibility of 4D-PET (Gated PET) acquisition, to reduce respiratory motion artifact in PET imaging of the thorax. In this study, we expand our investigation to address the problem of respiration motion in PET/CT imaging. The respiratory motion of four lung cancer patients were monitored by tracking external markers placed on the thorax. A 4D-CT acquisition was performed using a 'step-and-shoot' technique, in which computed tomography (CT) projection data were acquired over a complete respiratory cycle at each couch position. The period of each CT acquisition segment was time stamped with an 'x-ray ON' signal, which was recorded by the tracking system. 4D-CT data were then sorted into 10 groups, according to their corresponding phase of the breathing cycle. 4D-PET data were acquired in the gated mode, where each breathing cycle was divided into ten 0.5 s bins. For both CT and PET acquisitions, patients received audio prompting to regularize breathing. The 4D-CT and 4D-PET data were then correlated according to respiratory phase. The effect of 4D acquisition on improving the co-registration of PET and CT images, reducing motion smearing, and consequently increase the quantitation of the SUV, were investigated. Also, quantitation of the tumor motions in PET, and CT, were studied and compared. 4D-PET with matching phase 4D-CTAC showed an improved accuracy in PET-CT image co-registration of up to 41%, compared to measurements from 4D-PET with clinical-CTAC. Gating PET data in correlation with respiratory motion reduced motion-induced smearing, thereby decreasing the observed tumor volume, by as much as 43%. 4D-PET lesions volumes showed a maximum deviation of 19% between clinical CT and phase- matched 4D-CT attenuation corrected PET images. In CT, 4D acquisition resulted in increasing the tumor volume in two patients by up to 79%, and decreasing it in the other two by up to 35%. Consequently, these

  16. Planck 2015 results. XIX. Constraints on primordial magnetic fields

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Arroja, F.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Ballardini, M.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Chamballu, A.; Chiang, H. C.; Chluba, J.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Finelli, F.; Florido, E.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kim, J.; Kisner, T. S.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leahy, J. P.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oppermann, N.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Ruiz-Granados, B.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Shiraishi, M.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-08-01

    We compute and investigate four types of imprint of a stochastic background of primordial magnetic fields (PMFs) on the cosmic microwave background (CMB) anisotropies: the impact of PMFs on the CMB temperature and polarization spectra, which is related to their contribution to cosmological perturbations; the effect on CMB polarization induced by Faraday rotation; the impact of PMFs on the ionization history; magnetically-induced non-Gaussianities and related non-zero bispectra; and the magnetically-induced breaking of statistical isotropy. We present constraints on the amplitude of PMFs that are derived from different Planck data products, depending on the specific effect that is being analysed. Overall, Planck data constrain the amplitude of PMFs to less than a few nanoGauss, with different bounds that depend on the considered model. In particular, individual limits coming from the analysis of the CMB angular power spectra, using the Planck likelihood, are B1 Mpc < 4.4 nG (where B1 Mpc is the comoving field amplitude at a scale of 1 Mpc) at 95% confidence level, assuming zero helicity. By considering the Planck likelihood, based only on parity-even angular power spectra, we obtain B1 Mpc < 5.6 nG for a maximally helical field. For nearly scale-invariant PMFs we obtain B1 Mpc < 2.0 nG and B1 Mpc < 0.9 nG if the impact of PMFs on the ionization history of the Universe is included in the analysis. From the analysis of magnetically-induced non-Gaussianity, we obtain three different values, corresponding to three applied methods, all below 5 nG. The constraint from the magnetically-induced passive-tensor bispectrum is B1 Mpc < 2.8 nG. A search for preferred directions in the magnetically-induced passive bispectrum yields B1 Mpc < 4.5 nG, whereas the compensated-scalar bispectrum gives B1 Mpc < 3 nG. The analysis of the Faraday rotation of CMB polarization by PMFs uses the Planck power spectra in EE and BB at 70 GHz and gives B1 Mpc < 1380 nG. In our final analysis, we

  17. Qualitative grading of aortic regurgitation: a pilot study comparing CMR 4D flow and echocardiography.

    PubMed

    Chelu, Raluca G; van den Bosch, Annemien E; van Kranenburg, Matthijs; Hsiao, Albert; van den Hoven, Allard T; Ouhlous, Mohamed; Budde, Ricardo P J; Beniest, Kirsten M; Swart, Laurens E; Coenen, Adriaan; Lubbers, Marisa M; Wielopolski, Piotr A; Vasanawala, Shreyas S; Roos-Hesselink, Jolien W; Nieman, Koen

    2016-02-01

    Over the past 10 years there has been intense research in the development of volumetric visualization of intracardiac flow by cardiac magnetic resonance (CMR).This volumetric time resolved technique called CMR 4D flow imaging has several advantages over standard CMR. It offers anatomical, functional and flow information in a single free-breathing, ten-minute acquisition. However, the data obtained is large and its processing requires dedicated software. We evaluated a cloud-based application package that combines volumetric data correction and visualization of CMR 4D flow data, and assessed its accuracy for the detection and grading of aortic valve regurgitation using transthoracic echocardiography as reference. Between June 2014 and January 2015, patients planned for clinical CMR were consecutively approached to undergo the supplementary CMR 4D flow acquisition. Fifty four patients(median age 39 years, 32 males) were included. Detection and grading of the aortic valve regurgitation using CMR4D flow imaging were evaluated against transthoracic echocardiography. The agreement between 4D flow CMR and transthoracic echocardiography for grading of aortic valve regurgitation was good (j = 0.73). To identify relevant,more than mild aortic valve regurgitation, CMR 4D flow imaging had a sensitivity of 100 % and specificity of 98 %. Aortic regurgitation can be well visualized, in a similar manner as transthoracic echocardiography, when using CMR 4D flow imaging. PMID:26498478

  18. 2,4-D resistance in wild radish: reduced herbicide translocation via inhibition of cellular transport

    PubMed Central

    Goggin, Danica E.; Cawthray, Gregory R.; Powles, Stephen B.

    2016-01-01

    Resistance to auxinic herbicides is increasing in a range of dicotyledonous weed species, but in most cases the biochemical mechanism of resistance is unknown. Using 14C-labelled herbicide, the mechanism of resistance to 2,4-dichlorophenoxyacetic acid (2,4-D) in two wild radish (Raphanus raphanistrum L.) populations was identified as an inability to translocate 2,4-D out of the treated leaf. Although 2,4-D was metabolized in wild radish, and in a different manner to the well-characterized crop species wheat and bean, there was no difference in metabolism between the susceptible and resistant populations. Reduced translocation of 2,4-D in the latter was also not due to sequestration of the herbicide, or to reduced uptake by the leaf epidermis or mesophyll cells. Application of auxin efflux or ABCB transporter inhibitors to 2,4-D-susceptible plants caused a mimicking of the reduced-translocation resistance phenotype, suggesting that 2,4-D resistance in the populations under investigation could be due to an alteration in the activity of a plasma membrane ABCB-type auxin transporter responsible for facilitating long-distance transport of 2,4-D. PMID:26994475

  19. Generation and preclinical characterization of an antibody specific for SEMA4D

    PubMed Central

    Fisher, Terrence L.; Reilly, Christine A.; Winter, Laurie A.; Pandina, Tracy; Jonason, Alan; Scrivens, Maria; Balch, Leslie; Bussler, Holm; Torno, Sebold; Seils, Jennifer; Mueller, Loretta; Huang, He; Klimatcheva, Ekaterina; Howell, Alan; Kirk, Renee; Evans, Elizabeth; Paris, Mark; Leonard, John E.; Smith, Ernest S.; Zauderer, Maurice

    2016-01-01

    Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. Blocking the binding of SEMA4D to its receptors can result in physiologic changes that may have implications in cancer, autoimmune, and neurological disease. To study the effects of blocking SEMA4D, we generated, in SEMA4D-deficient mice, a panel of SEMA4D-specific hybridomas that react with murine, primate, and human SEMA4D. Utilizing the complementarity-determining regions from one of these hybridomas (mAb 67-2), we generated VX15/2503, a humanized IgG4 monoclonal antibody that is currently in clinical development for the potential treatment of various malignancies and neurodegenerative disorders, including multiple sclerosis and Huntington's disease. This work describes the generation and characterization of VX15/2503, including in vitro functional testing, epitope mapping, and an in vivo demonstration of efficacy in an animal model of rheumatoid arthritis. PMID:26431358

  20. Universal Landau Pole at the Planck scale

    SciTech Connect

    Andrianov, Alexander A.; Espriu, Domenec; Kurkov, Maxim A.; Lizzi, Fedele

    2014-07-23

    The concept of quantum gravity entails that the usual geometry loses its meaning at very small distances and therefore the grand unification of all gauge interactions with the property of asymptotic freedom happens to be questionable. We propose an unification of all gauge interactions in the form of an “Universal Landau Pole” (ULP), at which all gauge couplings diverge (or, better to say, become very strong). We show that the Higgs quartic coupling also substantially increases whereas the Yukawa couplings tend to zero. Such a singular (or strong coupling) unification is obtained after adding to the Standard Model matter more fermions with vector gauge couplings and hypercharges identical to the SM fermions. The influence of new particles also may prevent the Higgs quartic coupling from crossing zero, thus avoiding the instability (or metastability) of the SM vacuum. As well this fermion pattern opens a way to partially solve the hierarchy problem between masses of quarks and leptons.

  1. Fluorescent caged compounds of 2,4-dichlorophenoxyacetic acid (2,4-d): photorelease technology for controlled release of 2,4-D.

    PubMed

    Atta, Sanghamitra; Jana, Avijit; Ananthakirshnan, Rajakumar; Narayana Dhuleep, Pradeep Singh

    2010-11-24

    A novel controlled-release formulation (CRF) of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) was developed to reduce its negative environmental impacts by improving its herbicidal efficacy. The 2,4-D was chemically caged by coupling with photoremovable protecting groups (PRPGs) of coumarin derivatives. Photophysical studies of caged compounds showed that they all exhibited strong fluorescence properties. Controlled release of 2,4-D was achieved by irradiating the caged compounds using UV-vis light (310, 350, and 410 nm). The effect of various factors such as pH, solvent, and different substituents at the seventh position of coumarin moiety on the rate of photorelease was studied. The herbicidal activity of caged compounds and 4-(hydroxymethyl)-7-substituted coumarins was studied against Vigna radiata . The new formulation provided greater control over the release of 2,4-D by UV-vis light and also demonstrated the potential of the PRPGs not only to act as a delivery device but also to possess herbicidal activity after photorelease.

  2. Clinical evaluation of 4D PET motion compensation strategies for treatment verification in ion beam therapy

    NASA Astrophysics Data System (ADS)

    Gianoli, Chiara; Kurz, Christopher; Riboldi, Marco; Bauer, Julia; Fontana, Giulia; Baroni, Guido; Debus, Jürgen; Parodi, Katia

    2016-06-01

    A clinical trial named PROMETHEUS is currently ongoing for inoperable hepatocellular carcinoma (HCC) at the Heidelberg Ion Beam Therapy Center (HIT, Germany). In this framework, 4D PET-CT datasets are acquired shortly after the therapeutic treatment to compare the irradiation induced PET image with a Monte Carlo PET prediction resulting from the simulation of treatment delivery. The extremely low count statistics of this measured PET image represents a major limitation of this technique, especially in presence of target motion. The purpose of the study is to investigate two different 4D PET motion compensation strategies towards the recovery of the whole count statistics for improved image quality of the 4D PET-CT datasets for PET-based treatment verification. The well-known 4D-MLEM reconstruction algorithm, embedding the motion compensation in the reconstruction process of 4D PET sinograms, was compared to a recently proposed pre-reconstruction motion compensation strategy, which operates in sinogram domain by applying the motion compensation to the 4D PET sinograms. With reference to phantom and patient datasets, advantages and drawbacks of the two 4D PET motion compensation strategies were identified. The 4D-MLEM algorithm was strongly affected by inverse inconsistency of the motion model but demonstrated the capability to mitigate the noise-break-up effects. Conversely, the pre-reconstruction warping showed less sensitivity to inverse inconsistency but also more noise in the reconstructed images. The comparison was performed by relying on quantification of PET activity and ion range difference, typically yielding similar results. The study demonstrated that treatment verification of moving targets could be accomplished by relying on the whole count statistics image quality, as obtained from the application of 4D PET motion compensation strategies. In particular, the pre-reconstruction warping was shown to represent a promising choice when combined with intra

  3. Simultaneous motion estimation and image reconstruction (SMEIR) for 4D cone-beam CT

    NASA Astrophysics Data System (ADS)

    Wang, Jing; Gu, Xuejun

    2014-03-01

    Image reconstruction and motion model estimation in four dimensional cone-beam CT (4D-CBCT) are conventionally handled as two sequential steps. Due to the limited number of projections at each phase, the image quality of 4D-CBCT is degraded by view aliasing artifacts, and the accuracy of subsequent motion modeling is decreased by the inferior 4DCBCT. The objective of this work is to enhance both the image quality of 4D-CBCT and the accuracy of motion model estimation with a novel strategy enabling simultaneous motion estimation and image reconstruction (SMEIR). The proposed SMEIR algorithm consists of two alternating steps: 1) model-based iterative image reconstruction to obtain a motion-compensated primary CBCT (m-pCBCT) and 2) motion model estimation to obtain an optimal set of deformation vector fields (DVFs) between the m-pCBCT and other 4D-CBCT phases. The motion-compensated image reconstruction is based on the simultaneous algebraic reconstruction (SART) technique coupled with total variation minimization. During the forward- and back-projection of SART, measured projections from an entire set of 4D-CBCT are used for reconstruction of the m-pCBCT by utilizing the updated DVF. The DVF is estimated by matching the forward projection of the deformed m-pCBCT and measured projections of other phases of 4D-CBCT. The performance of the SMEIR algorithm is quantitatively evaluated on a 4D NCAT phantom. The SMEIR algorithm improves image reconstruction accuracy of 4D-CBCT and tumor motion trajectory estimation accuracy as compared to conventional sequential 4D-CBCT reconstruction and motion estimation.

  4. Clinical evaluation of 4D PET motion compensation strategies for treatment verification in ion beam therapy.

    PubMed

    Gianoli, Chiara; Kurz, Christopher; Riboldi, Marco; Bauer, Julia; Fontana, Giulia; Baroni, Guido; Debus, Jürgen; Parodi, Katia

    2016-06-01

    A clinical trial named PROMETHEUS is currently ongoing for inoperable hepatocellular carcinoma (HCC) at the Heidelberg Ion Beam Therapy Center (HIT, Germany). In this framework, 4D PET-CT datasets are acquired shortly after the therapeutic treatment to compare the irradiation induced PET image with a Monte Carlo PET prediction resulting from the simulation of treatment delivery. The extremely low count statistics of this measured PET image represents a major limitation of this technique, especially in presence of target motion. The purpose of the study is to investigate two different 4D PET motion compensation strategies towards the recovery of the whole count statistics for improved image quality of the 4D PET-CT datasets for PET-based treatment verification. The well-known 4D-MLEM reconstruction algorithm, embedding the motion compensation in the reconstruction process of 4D PET sinograms, was compared to a recently proposed pre-reconstruction motion compensation strategy, which operates in sinogram domain by applying the motion compensation to the 4D PET sinograms. With reference to phantom and patient datasets, advantages and drawbacks of the two 4D PET motion compensation strategies were identified. The 4D-MLEM algorithm was strongly affected by inverse inconsistency of the motion model but demonstrated the capability to mitigate the noise-break-up effects. Conversely, the pre-reconstruction warping showed less sensitivity to inverse inconsistency but also more noise in the reconstructed images. The comparison was performed by relying on quantification of PET activity and ion range difference, typically yielding similar results. The study demonstrated that treatment verification of moving targets could be accomplished by relying on the whole count statistics image quality, as obtained from the application of 4D PET motion compensation strategies. In particular, the pre-reconstruction warping was shown to represent a promising choice when combined with intra

  5. From WMAP to Planck: Exact Reconstruction of Four- and Five-dimensional Inflationary Potential from High-precision Cosmic Microwave Background Measurements

    NASA Astrophysics Data System (ADS)

    Popa, L. A.; Mandolesi, N.; Caramete, A.; Burigana, C.

    2009-12-01

    We make a more general determination of the inflationary observables in the standard four-dimensional (4D) and five-dimensional (5D) single-field inflationary scenarios by the exact reconstruction of the dynamics of the inflation potential during the observable inflation with a minimal number of assumptions: the computation does not assume the slow-roll approximation and is valid in all regimes if the field is monotonically rolling down its potential. We address higher order effects in the standard and braneworld single-field inflation scenarios by fitting the Hubbble expansion rate and subsequently the inflationary potential directly to WMAP5+SN+BAO and Planck-like simulated data sets. Making use of the Hamilton-Jacobi formalism developed for the 5D single-field inflation model, we compute the scale dependence of the amplitudes of the scalar and tensor perturbations by integrating the exact mode equation. The solutions in 4D and 5D inflation scenarios differ through the dynamics of the background scalar field and the number of e-folds assumed to be compatible with the observational window of inflation. We analyze the implications of the theoretical uncertainty in the determination of the reheating temperature after inflation on the observable predictions of inflation and evaluate its impact on the degeneracy of the standard inflation consistency relation. We find that the detection of tensor perturbations and the theoretical uncertainties in the inflationary observable represents a significant challenge for the future Planck cosmic microwave background measurements: distinguishing between the observational signatures of the standard and braneworld single-field inflation scenarios. This work has been done in the frame of Planck Core Team activities.

  6. FROM WMAP TO PLANCK: EXACT RECONSTRUCTION OF FOUR- AND FIVE-DIMENSIONAL INFLATIONARY POTENTIAL FROM HIGH-PRECISION COSMIC MICROWAVE BACKGROUND MEASUREMENTS

    SciTech Connect

    Popa, L. A.; Caramete, A.; Mandolesi, N.; Burigana, C.

    2009-12-01

    We make a more general determination of the inflationary observables in the standard four-dimensional (4D) and five-dimensional (5D) single-field inflationary scenarios by the exact reconstruction of the dynamics of the inflation potential during the observable inflation with a minimal number of assumptions: the computation does not assume the slow-roll approximation and is valid in all regimes if the field is monotonically rolling down its potential. We address higher order effects in the standard and braneworld single-field inflation scenarios by fitting the Hubbble expansion rate and subsequently the inflationary potential directly to WMAP5+SN+BAO and Planck-like simulated data sets. Making use of the Hamilton-Jacobi formalism developed for the 5D single-field inflation model, we compute the scale dependence of the amplitudes of the scalar and tensor perturbations by integrating the exact mode equation. The solutions in 4D and 5D inflation scenarios differ through the dynamics of the background scalar field and the number of e-folds assumed to be compatible with the observational window of inflation. We analyze the implications of the theoretical uncertainty in the determination of the reheating temperature after inflation on the observable predictions of inflation and evaluate its impact on the degeneracy of the standard inflation consistency relation. We find that the detection of tensor perturbations and the theoretical uncertainties in the inflationary observable represents a significant challenge for the future Planck cosmic microwave background measurements: distinguishing between the observational signatures of the standard and braneworld single-field inflation scenarios. This work has been done in the frame of Planck Core Team activities.

  7. Bacterial degradation of phenoxy herbicide mixtures 2,4-D and MCPP

    SciTech Connect

    Kyeheon Oh; Tuovinen, O.H. )

    1991-08-01

    The phenoxy herbicides 2,4-dichlorophenoxyacetic acid (2,4-D) and 2-(2-methyl-4-chlorophenoxy)propionic acid (MCPP) have auxin-like growth regulating properties and are extensively used for the control of broad-leaf angiosperm weeds. The microbiological degradation of 2,4-D by pure and mixed cultures has been examined in a number of studies. The authors have previously evaluated the concurrent microbiological degradation of 2,4-D and MCPP in stirred tank reactors. For the present paper, they examined the utilization of the two substrates by three mixed cultures that had a previous history of growth with the respective single phenoxy herbicide.

  8. SU-E-J-241: Creation of Ventilation CT From Daily 4D CTs Or 4D Conebeam CTs Acquired During IGRT for Thoracic Cancers

    SciTech Connect

    Tai, A; Ahunbay, E; Li, X

    2014-06-01

    Purpose: To develop a method to create ventilation CTs from daily 4D CTs or 4D KV conebeam CTs (4DCBCT) acquired during image-guided radiation therapy (IGRT) for thoracic tumors, and to explore the potential for using the ventilation CTs as a means for early detection of lung injury during radiation treatment. Methods: 4DCT acquired using an in-room CT (CTVision, Siemens) and 4DCBCT acquired using the X-ray Volume Imaging (XVI) system (Infinity, Elekta) for representative lung cancer patients were analyzed. These 4D data sets were sorted into 10 phase images. A newly-available deformable image registration tool (ADMIRE, Elekta) is used to deform the phase images at the end of exhale (EE) to the phase images at the end of inhale (EI). The lung volumes at EI and EE were carefully contoured using an intensity-based auto-contour tool and then manually edited. The ventilation images were calculated from the variations of CT numbers of those voxels masked by the lung contour at EI between the registered phase images. The deformable image registration is also performed between the daily 4D images and planning 4DCT, and the resulting deformable field vector (DFV) is used to deform the planning doses to the daily images by an in-house Matlab program. Results: The ventilation images were successfully created. The tide volumes calculated using the ventilation images agree with those measured through volume difference of contours at EE and EI, indicating the accuracy of ventilation images. The association between the delivered doses and the change of lung ventilation from the daily ventilation CTs is identified. Conclusions: A method to create the ventilation CT using daily 4DCTs or 4D KV conebeam CTs was developed and demonstrated.

  9. Fokker Planck theory for energetic electron deposition in laser fusion

    NASA Astrophysics Data System (ADS)

    Manheimer, Wallace; Colombant, Denis

    2014-10-01

    We have developed a Fokker Planck model to calculate the transport and deposition of energetic electrons, produced for instance by the two plasmon decay instability at the quarter critical surface. In steady state, the Fokker Planck equation reduces to a single universal equation in energy and space, an equation which appears to be quite simple, but which has a rather unconventional boundary condition. The equation is equally valid in planar and spherical geometry, and it depends on only a single parameter, the charge state Z. Hence one can solve for a universal solution, valid for each Z. An asymptotic solution to this equation will be presented, which allows the heating of the main plasma to be calculated from a simple analytical expression. A more accurate solution in terms of a Bessel function expansion will also be presented. From this, one obtains a heating rate which can be simply incorporated into fluid simulations.

  10. Resurrecting power law inflation in the light of Planck results

    SciTech Connect

    Unnikrishnan, Sanil; Sahni, Varun E-mail: varun@iucaa.ernet.in

    2013-10-01

    It is well known that a canonical scalar field with an exponential potential can drive power law inflation (PLI). However, the tensor-to-scalar ratio in such models turns out to be larger than the stringent limit set by recent Planck results. We propose a new model of power law inflation for which the scalar spectra index, the tensor-to-scalar ratio and the non-gaussianity parameter f{sub N{sub L}{sup equil}} are in excellent agreement with Planck results. Inflation, in this model, is driven by a non-canonical scalar field with an inverse power law potential. The Lagrangian for our model is structurally similar to that of a canonical scalar field and has a power law form for the kinetic term. A simple extension of our model resolves the graceful exit problem which usually afflicts models of power law inflation.

  11. Planck 2013 results. XV. CMB power spectra and likelihood

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bobin, J.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bridges, M.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Chiang, L.-Y.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Gaier, T. C.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giardino, G.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jewell, J.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kiiveri, K.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Laureijs, R. J.; Lawrence, C. R.; Le Jeune, M.; Leach, S.; Leahy, J. P.; Leonardi, R.; León-Tavares, J.; Lesgourgues, J.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; Lindholm, V.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Marinucci, D.; Maris, M.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Menegoni, E.; Mennella, A.; Migliaccio, M.; Millea, M.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; O'Dwyer, I. J.; Orieux, F.; Osborne, S.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Paykari, P.; Perdereau, O.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rahlin, A.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ringeval, C.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Sanselme, L.; Santos, D.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Starck, J.-L.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sureau, F.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Tavagnacco, D.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Türler, M.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Varis, J.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; White, M.; White, S. D. M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2014-11-01

    This paper presents the Planck 2013 likelihood, a complete statistical description of the two-point correlation function of the CMB temperature fluctuations that accounts for all known relevant uncertainties, both instrumental and astrophysical in nature. We use this likelihood to derive our best estimate of the CMB angular power spectrum from Planck over three decades in multipole moment, ℓ, covering 2 ≤ ℓ ≤ 2500. The main source of uncertainty at ℓ ≲ 1500 is cosmic variance. Uncertainties in small-scale foreground modelling and instrumental noise dominate the error budget at higher ℓs. For ℓ < 50, our likelihood exploits all Planck frequency channels from 30 to 353 GHz, separating the cosmological CMB signal from diffuse Galactic foregrounds through a physically motivated Bayesian component separation technique. At ℓ ≥ 50, we employ a correlated Gaussian likelihood approximation based on a fine-grained set of angular cross-spectra derived from multiple detector combinations between the 100, 143, and 217 GHz frequency channels, marginalising over power spectrum foreground templates. We validate our likelihood through an extensive suite of consistency tests, and assess the impact of residual foreground and instrumental uncertainties on the final cosmological parameters. We find good internal agreement among the high-ℓ cross-spectra with residuals below a few μK2 at ℓ ≲ 1000, in agreement with estimated calibration uncertainties. We compare our results with foreground-cleaned CMB maps derived from all Planck frequencies, as well as with cross-spectra derived from the 70 GHz Planck map, and find broad agreement in terms of spectrum residuals and cosmological parameters. We further show that the best-fit ΛCDM cosmology is in excellent agreement with preliminary PlanckEE and TE polarisation spectra. We find that the standard ΛCDM cosmology is well constrained by Planck from the measurements at ℓ ≲ 1500. One specific example is the

  12. Constraints on Cosmological Parameters: Combining Planck With Other Measurements

    NASA Astrophysics Data System (ADS)

    Freedman, Wendy

    2015-08-01

    The recent measurements from Planck have set a new high bar for accuracy in the measurement of cosmological parameters. In parallel, new and increasingly accurate measurements of Baryon Acoustic Oscillations, Type Ia supernovae, and the Hubble Constant offer independent probes of various cosmological parameters. The increased accuracy in cosmic microwave background fluctuation measurements make direct comparisons with other methods even more critical, given the intrinsic physical degeneracies amongst different cosmological parameters in the acoustic oscillation spectrum. There has been fundamental progress over the last couple of decades in measuring extragalactic distances. I will discuss the current limits, and the prospects for reaching 1% uncertainty in measurement of the Hubble constant, which, combined with measurements from Planck, will be critical for providing independent constraints on dark energy, the geometry, and matter density of the universe.

  13. Mixed inflaton and spectator field models after Planck

    SciTech Connect

    Enqvist, Kari; Takahashi, Tomo E-mail: tomot@cc.saga-u.ac.jp

    2013-10-01

    We investigate the possibility that the primordial perturbation has two sources: the inflaton and a spectator field, which is not dynamically important during inflation but which after inflation can contribute to the curvature perturbation. We derive the constraints on the model by using recent Planck results on the spectral index, tensor-to-scalar ratio and nonlinearity parameters f{sub NL} and τ{sub NL} for the cases with and without specifying the inflation and spectator models. If one chooses the spectator to be the curvaton with a quadratic potential, non-Gaussianities can be computed and imply restrictions on possible values of the ratio of the spectator-to-inflaton power R. We also consider a mixed curvaton and chaotic inflation model and show that even quartic chaotic inflation is still feasible in the context of mixed models even with Planck data.

  14. Equilibrium distribution of heavy quarks in fokker-planck dynamics

    PubMed

    Walton; Rafelski

    2000-01-01

    We obtain an explicit generalization, within Fokker-Planck dynamics, of Einstein's relation between drag, diffusion, and the equilibrium distribution for a spatially homogeneous system, considering both the transverse and longitudinal diffusion for dimension n>1. We provide a complete characterization of the equilibrium distribution in terms of the drag and diffusion transport coefficients. We apply this analysis to charm quark dynamics in a thermal quark-gluon plasma for the case of collisional equilibration.

  15. Chaotic universe dynamics using a Fokker-Planck equation

    SciTech Connect

    Coule, D.H.; Olynyk, K.O.

    1987-07-01

    A Fokker-Planck equation that accounts for fluctuations in field and its conjugate momentum is solved numerically for the case of a lambda phi/sup 4/ potential. Although the amount of inflation agrees closely with that expected classically, in certain cases (large initial fields or large dispersions),the ''slow rolling'' approximation appears invalid. In such cases inflation would stop prematurely before possibly restarting. 18 refs., 2 figs.

  16. COSMOLOGY FROM GRAVITATIONAL LENS TIME DELAYS AND PLANCK DATA

    SciTech Connect

    Suyu, S. H.; Treu, T.; Sonnenfeld, A.; Hilbert, S.; Spiniello, C.; Auger, M. W.; Collett, T.; Blandford, R. D.; Marshall, P. J.; Courbin, F.; Meylan, G.; Tewes, M.; Fassnacht, C. D.; Koopmans, L. V. E.

    2014-06-20

    Under the assumption of a flat ΛCDM cosmology, recent data from the Planck satellite point toward a Hubble constant that is in tension with that measured by gravitational lens time delays and by the local distance ladder. Prosaically, this difference could arise from unknown systematic uncertainties in some of the measurements. More interestingly—if systematics were ruled out—resolving the tension would require a departure from the flat ΛCDM cosmology, introducing, for example, a modest amount of spatial curvature, or a non-trivial dark energy equation of state. To begin to address these issues, we present an analysis of the gravitational lens RXJ1131–1231 that is improved in one particular regard: we examine the issue of systematic error introduced by an assumed lens model density profile. We use more flexible gravitational lens models with baryonic and dark matter components, and find that the exquisite Hubble Space Telescope image with thousands of intensity pixels in the Einstein ring and the stellar velocity dispersion of the lens contain sufficient information to constrain these more flexible models. The total uncertainty on the time-delay distance is 6.6% for a single system. We proceed to combine our improved time-delay distance measurement with the WMAP9 and Planck posteriors. In an open ΛCDM model, the data for RXJ1131–1231 in combination with Planck favor a flat universe with Ω{sub k}=0.00{sub −0.02}{sup +0.01} (68% credible interval (CI)). In a flat wCDM model, the combination of RXJ1131–1231 and Planck yields w=−1.52{sub −0.20}{sup +0.19} (68% CI)

  17. Planck 2015 results. XVI. Isotropy and statistics of the CMB

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Akrami, Y.; Aluri, P. K.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Casaponsa, B.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Contreras, D.; Couchot, F.; Coulais, A.; Crill, B. P.; Cruz, M.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fantaye, Y.; Fergusson, J.; Fernandez-Cobos, R.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Frolov, A.; Galeotta, S.; Galli, S.; Ganga, K.; Gauthier, C.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huang, Z.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kim, J.; Kisner, T. S.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; Liu, H.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marinucci, D.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mikkelsen, K.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Pant, N.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Rotti, A.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Souradeep, T.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Trombetti, T.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zibin, J. P.; Zonca, A.

    2016-08-01

    We test the statistical isotropy and Gaussianity of the cosmic microwave background (CMB) anisotropies using observations made by the Planck satellite. Our results are based mainly on the full Planck mission for temperature, but also include some polarization measurements. In particular, we consider the CMB anisotropy maps derived from the multi-frequency Planck data by several component-separation methods. For the temperature anisotropies, we find excellent agreement between results based on these sky maps over both a very large fraction of the sky and a broad range of angular scales, establishing that potential foreground residuals do not affect our studies. Tests of skewness, kurtosis, multi-normality, N-point functions, and Minkowski functionals indicate consistency with Gaussianity, while a power deficit at large angular scales is manifested in several ways, for example low map variance. The results of a peak statistics analysis are consistent with the expectations of a Gaussian random field. The "Cold Spot" is detected with several methods, including map kurtosis, peak statistics, and mean temperature profile. We thoroughly probe the large-scale dipolar power asymmetry, detecting it with several independent tests, and address the subject of a posteriori correction. Tests of directionality suggest the presence of angular clustering from large to small scales, but at a significance that is dependent on the details of the approach. We perform the first examination of polarization data, finding the morphology of stacked peaks to be consistent with the expectations of statistically isotropic simulations. Where they overlap, these results are consistent with the Planck 2013 analysis based on the nominal mission data and provide our most thorough view of the statistics of the CMB fluctuations to date.

  18. Low 2D:4D Values Are Associated with Video Game Addiction

    PubMed Central

    Kornhuber, Johannes; Zenses, Eva-Maria; Lenz, Bernd; Stoessel, Christina; Bouna-Pyrrou, Polyxeni; Rehbein, Florian; Kliem, Sören; Mößle, Thomas

    2013-01-01

    Androgen-dependent signaling regulates the growth of the fingers on the human hand during embryogenesis. A higher androgen load results in lower 2D:4D (second digit to fourth digit) ratio values. Prenatal androgen exposure also impacts brain development. 2D:4D values are usually lower in males and are viewed as a proxy of male brain organization. Here, we quantified video gaming behavior in young males. We found lower mean 2D:4D values in subjects who were classified according to the CSAS-II as having at-risk/addicted behavior (n = 27) compared with individuals with unproblematic video gaming behavior (n = 27). Thus, prenatal androgen exposure and a hyper-male brain organization, as represented by low 2D:4D values, are associated with problematic video gaming behavior. These results may be used to improve the diagnosis, prediction, and prevention of video game addiction. PMID:24236143

  19. Low 2D:4D values are associated with video game addiction.

    PubMed

    Kornhuber, Johannes; Zenses, Eva-Maria; Lenz, Bernd; Stoessel, Christina; Bouna-Pyrrou, Polyxeni; Rehbein, Florian; Kliem, Sören; Mößle, Thomas

    2013-01-01

    Androgen-dependent signaling regulates the growth of the fingers on the human hand during embryogenesis. A higher androgen load results in lower 2D:4D (second digit to fourth digit) ratio values. Prenatal androgen exposure also impacts brain development. 2D:4D values are usually lower in males and are viewed as a proxy of male brain organization. Here, we quantified video gaming behavior in young males. We found lower mean 2D:4D values in subjects who were classified according to the CSAS-II as having at-risk/addicted behavior (n = 27) compared with individuals with unproblematic video gaming behavior (n = 27). Thus, prenatal androgen exposure and a hyper-male brain organization, as represented by low 2D:4D values, are associated with problematic video gaming behavior. These results may be used to improve the diagnosis, prediction, and prevention of video game addiction.

  20. Dissipation and residue of 2,4-D in citrus under field condition.

    PubMed

    Chen, Weijun; Jiao, Bining; Su, Xuesu; Zhao, Qiyang; Sun, Dali

    2015-05-01

    The dissipation, residues, and risks of 2,4-dicholrophenoxyacetic acid (2,4-D) in citrus under field condition were investigated based on a simple ultra-performance LC (UPLC)-MS/MS method. The results indicated that the residue level of 2,4-D in citrus did not degrade gradually with sampling time under field condition. At pre-harvest intervals (PHI) of 20-40 days, 2,4-D residues were 0.021-0.269 mg/kg in citrus flesh, 0.028-0.337 mg/kg in whole citrus, and 0.028-0.376 mg/kg in citrus peel, all bellow the China maximum residue limit in citrus (1 mg/kg). Risks of 2,4-D were assessed by calculation of risk quotient, and the results revealed no significant health risks after consumption of citrus.

  1. Bayesian evidence of the post-Planck curvaton

    SciTech Connect

    Hardwick, Robert J.; Byrnes, Christian T. E-mail: c.byrnes@sussex.ac.uk

    2015-08-01

    We perform a Bayesian model comparison for scenarios within the quadratic curvaton model, determining the degree to which both are disfavoured with respect to the ΛCDM concordance model and single-field quadratic inflation, using the recent Planck data release. Despite having three additional model parameters, the simplest curvaton scenario is not disfavoured relative to single-field quadratic inflation, and it becomes favoured against this single-field model when we include the joint BICEP/Keck/Planck analysis. In all cases we assume an instantaneous inflaton decay and no surviving isocurvature perturbations. Despite the success of Planck reaching its forecast measurement accuracy, we show that the current constraints on local non-Gaussianity are insufficiently precise to have any significant impact on the evidence ratios so far. We also determine the precision σ(f{sub NL}) required by future measurements assuming a fiducial value of f{sub NL}=−5/4 or 10.8 to no longer disfavour the curvaton against the ΛCDM parametrisation, and we discuss the effect that the predicted increase in precision from future measurements on f{sub NL} may have. We show that our results are not very sensitive to our choice of priors.

  2. An Efficient Numerical Approach for Nonlinear Fokker-Planck equations

    NASA Astrophysics Data System (ADS)

    Otten, Dustin; Vedula, Prakash

    2009-03-01

    Fokker-Planck equations which are nonlinear with respect to their probability densities that occur in many nonequilibrium systems relevant to mean field interaction models, plasmas, classical fermions and bosons can be challenging to solve numerically. To address some underlying challenges in obtaining numerical solutions, we propose a quadrature based moment method for efficient and accurate determination of transient (and stationary) solutions of nonlinear Fokker-Planck equations. In this approach the distribution function is represented as a collection of Dirac delta functions with corresponding quadrature weights and locations, that are in turn determined from constraints based on evolution of generalized moments. Properties of the distribution function can be obtained by solution of transport equations for quadrature weights and locations. We will apply this computational approach to study a wide range of problems, including the Desai-Zwanzig Model (for nonlinear muscular contraction) and multivariate nonlinear Fokker-Planck equations describing classical fermions and bosons, and will also demonstrate good agreement with results obtained from Monte Carlo and other standard numerical methods.

  3. Characteristics of GPS sources in the Planck survey

    NASA Astrophysics Data System (ADS)

    Volvach, A. E.; Kardashev, N. S.; Larionov, M. G.; Volvach, L. N.

    2016-09-01

    Two series of 22.2 and 36.8-GHz observations of 43 GHz-Peaked Spectrum (GPS) radio sources from the Planck survey have been carried out using the 22-m radio telescope of the Crimean Astrophysical Observatory in 2014-2015, with the aim of studying the variability of these sources. The interval between the two series of observations was about nine months. These data were analyzed together with the Planck data at frequencies from 20 to 143 GHz. The fraction of quasars among GPS sources grows to 90% at millimeter wavelengths, compared to 1.4% at decimeter wavelengths. The growth in the variability indices of Planck GPS sources is not as sharp as that observed at decimeter and centimeter wavelengths, and remains at a level of about 30% at millimeter wavelengths. This supports the view that GPS sources are not strongly variable, compared to other types of Active Galactic Nuclei (AGNs). A mean spectrumfor the GPS radio sources has been obtained, which is shallower at low frequencies and steeper at high frequencies atmillimeter wavelengths than at decimeter and centimeterwavelengths. These properties of the GPS spectra at millimeter wavelengths testify to the compactness of these sources and the dense, inhomogeneous nature of the medium in which they are located. This also indirectly suggests that these objects are young and that their active states have short lifetimes.

  4. Confronting the concordance model of cosmology with Planck data

    SciTech Connect

    Hazra, Dhiraj Kumar; Shafieloo, Arman E-mail: arman@apctp.org

    2014-01-01

    We confront the concordance (standard) model of cosmology, the spatially flat ΛCDM Universe with power-law form of the primordial spectrum with Planck CMB angular power spectrum data searching for possible smooth deviations beyond the flexibility of the standard model. The departure from the concordance cosmology is modeled in the context of Crossing statistic and statistical significance of this deviation is used as a measure to test the consistency of the standard model to the Planck data. Derived Crossing functions suggest the presence of some broad features in angular spectrum beyond the expectations of the concordance model. Our results indicate that the concordance model of cosmology is consistent to the Planck data only at 2 to 3σ confidence level if we allow smooth deviations from the angular power spectrum given by the concordance model. This might be due to random fluctuations or may hint towards smooth features in the primordial spectrum or departure from another aspect of the standard model. Best fit Crossing functions indicate that there are lack of power in the data at both low-ℓ and high-ℓ with respect to the concordance model. This hints that we may need some modifications in the foreground modeling to resolve the significant inconsistency at high-ℓ. However, presence of some systematics at high-ℓ might be another reason for the deviation we found in our analysis.

  5. Possible signature of distant foreground in the Planck data

    NASA Astrophysics Data System (ADS)

    Yershov, V. N.; Orlov, V. V.; Raikov, A. A.

    2014-12-01

    By using the Planck map of the cosmic microwave background (CMB) radiation, we have checked and confirmed the existence of a correlation between supernova (SN) redshifts, zSN, and CMB temperature fluctuations at the SNe locations, TSN, which we previously reported for the Wilkinson Microwave Anisotropy Probe data. The Pearson correlation coefficient for the Planck data is r = +0.38 ± 0.08, which indicates that the correlation is statistically significant (the signal is about 5σ above the noise level). The correlation becomes even stronger for the Type Ia subsample of SNe, rIa = +0.45 ± 0.09, whereas for the rest of the SNe it is vanishing. By checking the slopes of the regression lines TSN/zSN for Planck's different frequency bands, we have also excluded the possibility of this anomaly being caused by the Sunyaev-Zeldovich effect. The remaining possibility is some, unaccounted for, contribution to the CMB from distant (z > 0.3) foreground through either the integrated Sachs-Wolfe effect or thermal emission from intergalactic matter.

  6. New constraints on primordial gravitational waves from Planck 2015

    NASA Astrophysics Data System (ADS)

    Pagano, Luca; Salvati, Laura; Melchiorri, Alessandro

    2016-09-01

    We show that the new precise measurements of Cosmic Microwave Background (CMB) temperature and polarization anisotropies made by the Planck satellite significantly improves previous constraints on the cosmic gravitational waves background (CGWB) at frequencies f >10-15 Hz. On scales smaller than the horizon at the time of decoupling, primordial gravitational waves contribute to the total radiation content of the Universe. Considering adiabatic perturbations, CGWB affects temperature and polarization CMB power spectra and matter power spectrum in a manner identical to relativistic particles. Considering the latest Planck results we constrain the CGWB energy density to Ωgwh2 < 1.7 ×10-6 at 95% CL. Combining CMB power spectra with lensing, BAO and primordial Deuterium abundance observations, we obtain Ωgwh2 < 1.2 ×10-6 at 95% CL, improving previous Planck bounds by a factor 3 and the recent direct upper limit from the LIGO and VIRGO experiments a factor 2. A combined analysis of future satellite missions as COrE and EUCLID could improve current bound by more than an order of magnitude.

  7. What Planck does not tell us about inflation

    NASA Astrophysics Data System (ADS)

    Elliston, Joseph; Mulryne, David; Tavakol, Reza

    2013-09-01

    Planck data has not found the “smoking gun” of non-Gaussianity that would have necessitated consideration of inflationary models beyond the simplest canonical single-field scenarios. This raises the important question of what these results do imply for more general models, and in particular, multifield inflation. In this paper we revisit four ways in which two-field scenarios can behave differently from single-field models; two-field slow-roll dynamics, curvaton-type behavior, inflation ending on an inhomogeneous hypersurface and modulated reheating. We study the constraints that Planck data puts on these classes of behavior, focusing on the latter two which are the least studied in the recent literature. We show that these latter classes are almost equivalent, and extend their previous analyses by accounting for arbitrary evolution of the isocurvature mode which, in particular, places important limits on the Gaussian curvature of the reheating hypersurface. In general, however, we find that Planck bispectrum results only constrain certain regions of parameter space, leading us to conclude that inflation sourced by more than one scalar field remains an important possibility.

  8. Dielectric polarization in the Planck theory of sonoluminescence.

    PubMed

    Prevenslik, T V

    1998-11-01

    Sonoluminescence observed in the cavitation of liquid H2O may be explained by the Planck theory of SL, which treats the bubbles as collapsing miniature masers having optical waves standing in resonance with the dimensions of the bubble cavity. Microwaves are shown to be created from the Planck energy of the standing waves, provided the bubble wall can be treated as a perfect blackbody surface. Liquid H2O is strongly absorbent in the ultraviolet and there the bubble approaches a Planck blackbody enclosure. The microwaves are created at frequencies proportional to the bubble collapse velocity only to be promptly absorbed by the rotation quantum states of the H2O and other bubble wall molecules. The microwaves are absorbed discretely at rotation line frequencies, or continuously by dipole rotation at frequencies from 1 to 30 GHz. In the liquid state, molecular rotation of the H2O molecule is hindered and the microwave energy is rapidly turned into bending energy by intermolecular collisions. Subsequently, the bubble wall molecules may thereby ionize and produce visible photons. The microwaves create intense electrical fields in the bubble wall by dielectric polarization. If the gases adjacent to the bubble wall undergo electrical breakdown, free electrons are created, thereby providing sonoluminescence with a magnetic field effect.

  9. Residues of 2, 4-D in air samples from Saskatchewan: 1966-1975.

    PubMed

    Grover, R; Kerr, L A; Wallace, K; Yoshida, K; Maybank, J

    1976-01-01

    Residues of 2,4-D (2,4-dichlorophenoxyacetic acid) in air samples from several sampling sites in central and southern Saskatchewan during the spraying seasons in the 1966-68 and 1970-75 periods were determined by gas-liquid chromatographic techniques. Initially, individual esters of 2,4-D were characterized by retention times and confirmed further by co-injection and dual column procedures. Since 1973, however, only total 2,4-D acid levels in air samples have been determined after esterification to the methyl ester and confirmed by gc/ms techniques whenever possible. Up to 50% of the daily samples collected during the spraying season at any of the locations and during any given year contained 2,4-D, with butyl esters being found most frequently. The daily 24-hr mean atmospheric concentrations of 2,4-D ranged from 0.01 to 1.22 mug/m3, 0.01 to 13.50 mug/m3, and 0.05 to 0.59 mug/m3 for the iso-propyl, mixed butyl and iso-octyl esters, respectively. Even when the samples were analysed for the total 2,4-D content, i.e. from 1973 onwards, the maximum level of the total acid reached only 23.14 mug/m3. In any given year and at any of the sampling sites, about 30% of the samples contained less than 0.01 mug/m3 of 2,4-D. In another 40% of the samples, the levels of 2,4-D ranged from 0.01 to 0.099 mug/m3. Only about 30% of the samples contained 2,4-D concentrations higher than 0.1 mug/m3, with only 10% or less exceeding 1 mug/m3. None of the samples, obtained with the high volume particulate sampler, showed any detectable levels of 2,4-D, indicating little or no transport of 2,4-D adsorbed on dust particles or as crystals of amine salts. PMID:1002953

  10. Energy levels in Ag-like (4d{sup 10}4f, 4d{sup 10}5l (l = 0-3)), Pd-like (4d{sup 9}4f [J = 1], 4d{sup 9}5p [J = 1], 4d{sup 9}5f [J = 1]), and Rh-like (4d{sup 9} [J = 5/2, 3/2]) ions with Z {<=} 86

    SciTech Connect

    Ivanova, E.P.

    2009-11-15

    Relativistic perturbation theory with a model potential is used for the calculation of energy levels of the states 4f{sub 5/2}, 4f{sub 7/2}, 5s{sub 1/2}, 5p{sub 1/2}, 5p{sub 3/2}, 5d{sub 3/2}, 5d{sub 5/2}, 5f{sub 5/2}, and 5f{sub 7/2} above the 1s{sup 2}2s{sup 2}2p{sup 6}3s{sup 2}3p{sup 6}3d{sup 10}4s{sup 2}4p{sup 6}4d{sup 10} core, with one vacancy 4d{sub 5/2}{sup 9}, 4d{sub 7/2}{sup 9} in the same core, in the silver and rhodium isoelectronic sequences with the maximum nuclear charge Z = 86. The method of extrapolation of the model potential parameter is applied to calculate one-electron and one-vacancy wavefunctions. The wavefunctions of Ag- and Rh-like ions were used to calculate the energies of resonance transitions to the ground state {sup 1}S{sub 0} in Pd-like ions. Good agreement between the theoretical and the experimental energies of the resonance transitions in Pd-like ions indicates the reliability of the results obtained.

  11. Effect of pH and Electrolytes on Adsorption of 2,4-D onto Kaolinite

    NASA Astrophysics Data System (ADS)

    Sharma, A.; Kawamoto, K.; Komatsu, T.; Moldrup, P.

    2006-12-01

    The fate and transport of pesticides in soil can be greatly influenced by adsorption onto clay minerals such as kaolinite. The ionic pesticide 2,4-D (2,4-dichlorophenoxyacetic acid) is one of the most commonly used herbicides. The purpose of this study is to investigate the effect of electrolytes and pH on the adsorption of 2,4- D onto kaolinite. The adsorption coefficient (Kd) of 2,4-D on two types of kaolinite was measured in batch experiments using water and 4 different electrolytes (0.005M CaSO4, 0.005M CaCl2, 0.01M KCl, and 0.01M NaCl). The experiments were carried out with 0.5 g kaolinite at a solid:liquid ratio of 1:20 and at different pH (1.9-6.3). The pH of the solution was controlled by addition of 0.2N of HCl. X-ray diffraction analysis of both kaolinite with and without adsorbed 2,4-D was also done to understand the location of 2,4-D adsorption. The effects of pH and electrolytes on Kd were compared and possible adsorption mechanisms were revealed for 2,4-D adsorption onto the two different types of kaolinite. The results implied that 2,4-D adsorption was higher for an electrolyte solution with monovalent cation than with divalent cation for one type of kaolinite, while no such trend was observed for the other kaolinite. The adsorption of 2,4-D increased significantly with decreasing pH for both types of kaolinite.

  12. Details of the 1998 Watt Balance Experiment Determining the Planck Constant

    PubMed Central

    Steiner, Richard; Newell, David; Williams, Edwin

    2005-01-01

    The National Institute of Standards and Technology (NIST) watt balance experiment completed a determination of Planck constant in 1998 with a relative standard uncertainty of 87 × 10−9 (k = 1), concurrently with an upper limit on the drift rate of the SI kilogram mass standard. A number of other fundamental physical constants with uncertainties dominated by this result are also calculated. This paper focuses on the details of the balance apparatus, the measurement and control procedures, and the reference calibrations. The alignment procedures are also described, as is a novel mutual inductance measurement procedure. The analysis summary discusses the data noise sources and estimates for the Type B uncertainty contributions to the uncertainty budget. Much of this detail, some historical progression, and a few recent findings have not been included in previous papers reporting the results of this experiment. PMID:27308100

  13. Two carrier temperatures non-equilibrium generalized Planck law for semiconductors

    NASA Astrophysics Data System (ADS)

    Gibelli, François; Lombez, Laurent; Guillemoles, Jean-François

    2016-10-01

    Planck's law of radiation describes the light emitted by a blackbody. This law has been generalized in the past for the case of a non-blackbody material having a quasi Fermi-level splitting: the lattice of the material and the carriers are then considered in an isothermal regime. Hot carrier spectroscopy deals with carriers out of the isothermal regime, as their respective temperatures (THe ≠ THh) are considered to be different than that of the lattice (TL). Here we show that Fermi-Dirac distribution temperature for each type of carrier still determine an effective radiation temperature: an explicit relationship is given involving the effective masses. Moreover, we show how to determine, in principle with an additional approximation, the carrier temperatures (THe, THh) and the corresponding absolute electrochemical potentials from photoluminescence measurements.

  14. Cross-correlation of gravitational lensing from DES Science Verification data with SPT and Planck lensing

    SciTech Connect

    Kirk, D.; et al.

    2015-12-14

    We measure the cross-correlation between weak lensing of galaxy images and of the cosmic microwave background (CMB). The effects of gravitational lensing on different sources will be correlated if the lensing is caused by the same mass fluctuations. We use galaxy shape measurements from 139 deg$^{2}$ of the Dark Energy Survey (DES) Science Verification data and overlapping CMB lensing from the South Pole Telescope (SPT) and Planck. The DES source galaxies have a median redshift of $z_{\\rm med} {\\sim} 0.7$, while the CMB lensing kernel is broad and peaks at $z{\\sim}2$. The resulting cross-correlation is maximally sensitive to mass fluctuations at $z{\\sim}0.44$. Assuming the Planck 2015 best-fit cosmology, the amplitude of the DES$\\times$SPT cross-power is found to be $A = 0.88 \\pm 0.30$ and that from DES$\\times$Planck to be $A = 0.86 \\pm 0.39$, where $A=1$ corresponds to the theoretical prediction. These are consistent with the expected signal and correspond to significances of $2.9 \\sigma$ and $2.2 \\sigma$ respectively. We demonstrate that our results are robust to a number of important systematic effects including the shear measurement method, estimator choice, photometric redshift uncertainty and CMB lensing systematics. Significant intrinsic alignment of galaxy shapes would increase the cross-correlation signal inferred from the data; we calculate a value of $A = 1.08 \\pm 0.36$ for DES$\\times$SPT when we correct the observations with a simple IA model. With three measurements of this cross-correlation now existing in the literature, there is not yet reliable evidence for any deviation from the expected LCDM level of cross-correlation, given the size of the statistical uncertainties and the significant impact of systematic errors, particularly IAs. We provide forecasts for the expected signal-to-noise of the combination of the five-year DES survey and SPT-3G.

  15. Planck 2013 results. XXX. Cosmic infrared background measurements and implications for star formation

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bethermin, M.; Bielewicz, P.; Blagrave, K.; Bobin, J.; Bock, J. J.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bridges, M.; Bucher, M.; Burigana, C.; Butler, R. C.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chen, X.; Chiang, H. C.; Chiang, L.-Y.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Dupac, X.; Efstathiou, G.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Forni, O.; Frailis, M.; Franceschi, E.; Galeotta, S.; Ganga, K.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Hanson, D.; Harrison, D.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Kalberla, P.; Keihänen, E.; Kerp, J.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lacasa, F.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Langer, M.; Lasenby, A.; Laureijs, R. J.; Lawrence, C. R.; Leonardi, R.; León-Tavares, J.; Lesgourgues, J.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Osborne, S.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savini, G.; Scott, D.; Seiffert, M. D.; Serra, P.; Shellard, E. P. S.; Spencer, L. D.; Starck, J.-L.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sureau, F.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Tavagnacco, D.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Türler, M.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; Welikala, N.; White, M.; White, S. D. M.; Winkel, B.; Yvon, D.; Zacchei, A.; Zonca, A.

    2014-11-01

    We present new measurements of cosmic infrared background (CIB) anisotropies using Planck. Combining HFI data with IRAS, the angular auto- and cross-frequency power spectrum is measured from 143 to 3000 GHz, and the auto-bispectrum from 217 to 545 GHz. The total areas used to compute the CIB power spectrum and bispectrum are about 2240 and 4400 deg2, respectively. After careful removal of the contaminants (cosmic microwave background anisotropies, Galactic dust, and Sunyaev-Zeldovich emission), and a complete study of systematics, the CIB power spectrum is measured with unprecedented signal to noise ratio from angular multipoles ℓ ~ 150 to 2500. The bispectrum due to the clustering of dusty, star-forming galaxies is measured from ℓ ~ 130 to 1100, with a total signal to noise ratio of around 6, 19, and 29 at 217, 353, and 545 GHz, respectively. Two approaches are developed for modelling CIB power spectrum anisotropies. The first approach takes advantage of the unique measurements by Planck at large angular scales, and models only the linear part of the power spectrum, with a mean bias of dark matter haloes hosting dusty galaxies at a given redshift weighted by their contribution to the emissivities. The second approach is based on a model that associates star-forming galaxies with dark matter haloes and their subhaloes, using a parametrized relation between the dust-processed infrared luminosity and (sub-)halo mass. The two approaches simultaneously fit all auto- and cross-power spectra very well. We find that the star formation history is well constrained up to redshifts around 2, and agrees with recent estimates of the obscured star-formation density using Spitzer and Herschel. However, at higher redshift, the accuracy of the star formation history measurement is strongly degraded by the uncertainty in the spectral energy distribution of CIB galaxies. We also find that the mean halo mass which is most efficient at hosting star formation is log (Meff/M⊙) = 12

  16. Biolabeling with 2,4-dichlorophenoxyacetic acid derivatives: the 2,4-D tag.

    PubMed

    Bade, Steffen; Röckendorf, Niels; Franek, Milan; Gorris, Hans H; Lindner, Buko; Olivier, Verena; Schaper, Klaus-Jürgen; Frey, Andreas

    2009-12-01

    Many bioanalytic and diagnostic procedures rely on labels with which the molecule of interest can be tracked in or discriminated from accompanying like substances. Herein, we describe a new labeling and detection system based on derivatives of 2,4-dichlorophenoxyacetic acid (2,4-D) and anti-2,4-D antibodies. The 2,4-D system is highly sensitive with a K(D) of 7 x 10(-11) M for the hapten-antibody pair, can be used on a large variety of biomolecules such as proteins, peptides, carbohydrates, and nucleic acids, is not hampered by endogenous backgrounds because 2,4-D is a xenobiotic, and is robust because 2,4-D is a very stable compound that withstands the conditions of most reactions usually performed on biomolecules. With this unique blend of properties, the 2,4-D system compares favorably with its rivals digoxigenin (DIG)/anti-DIG and biotin/(strept)avidin and provides an interesting and powerful tool in biomolecular labeling.

  17. Respiratory motion variations from skin surface on lung cancer patients from 4D CT data

    NASA Astrophysics Data System (ADS)

    Gallego-Ortiz, Nicolas; Orban de Xivry, Jonathan; Descampe, Antonin; Goossens, Samuel; Geets, Xavier; Janssens, Guillaume; Macq, Benoit

    2014-03-01

    In radiation therapy of thorax and abdomen regions, knowing how respiratory motion modifies tumor position and trajectory is crucial for accurate dose delivery to tumors while avoiding healthy tissue and organs at risk. Three types of variations are studied: motion amplitudes measured from the patient's skin surface and internal tumor trajectory, internal/external correlations and tumor trajectory baseline shift. Four male patients with lung cancer with three repeated 4D computed tomography (4DCT) scans, taken on different treatment days, were studied. Surfaces were extracted from 4DCT scans by segmentation. Motion over specific regions of interest was analyzed with respect to the motion of the tumor center of mass and correlation coefficient was computed. Tumor baseline shifts were analyzed after rigid registration based on vertebrae and surface registration. External amplitude variations were observed between fractions. Correlation coefficients of internal trajectories and external distances are greater than 0.6 in the abdomen. This correlation was observable and significant for all patients showing that the external motion is a good surrogate for internal movement on an intra-fraction basis. However for the inter-fraction case, external amplitude variations were observed between fractions and no correlation was found with the internal amplitude variations. Moreover, baseline shifts after surface registration were greater than those after vertebrae registration and the mean distance between surfaces after registration was not correlated to the magnitude of the baseline shift. These two observations show that, with the current representation of the external surface, inter-fraction variations are not detectable on the surface.

  18. RNA interference-mediated knockdown of long-form phosphodiesterase-4D (PDE4D) enzyme reverses amyloid-β42-induced memory deficits in mice.

    PubMed

    Zhang, Cong; Cheng, Yufang; Wang, Haitao; Wang, Chuang; Wilson, Steven P; Xu, Jiangping; Zhang, Han-Ting

    2014-01-01

    Phosphodiesterase-4 (PDE4) inhibitors enhance memory, increase hippocampal neurogenesis, and reverse amyloid-β (Aβ)-induced memory deficits. Here, we examined whether long-form PDE4D knockdown by lentiviral RNA construct containing a specific microRNA/miRNA-mir hairpin structure (4DmiRNA) reversed memory impairment caused by amyloid-β1-42 (Aβ42) in mice using the Morris water maze (MWM) and novelty object recognition tests. Western blotting analysis was used to assess protein levels of cAMP response element-binding protein (CREB, unphosphorylated and phosphorylated [pCREB]), brain-derived neurotrophic factor (BDNF), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and nuclear factor-κB (NF-κB) to explore the neurochemical mechanisms. Aggregated Aβ42 (0.5 μg/side) bilaterally infused in dentate gyrus decreased cAMP levels (p < 0.01) and produced memory deficits in the MWM (p < 0.01) and object recognition tests (p < 0.01). Microinfusions of lentiviruses resulted in downregulated expression of PDE4D4 and 4D5 proteins and reversed Aβ42-induced cAMP decline (p < 0.05) and memory deficits. Treatment also concomitantly increased pCREB (p < 0.05) and BDNF (p < 0.01) and reduced IL-1β (p < 0.05), TNF-α (p < 0.01), and NF-κB (p65) (p < 0.05) in the hippocampus of Aβ42-challenged mice. These results suggest that long-form PDE4D knockdown may offer a promising treatment for memory loss associated with Alzheimer's disease.

  19. Final Technical Report for SBIR entitled Four-Dimensional Finite-Orbit-Width Fokker-Planck Code with Sources, for Neoclassical/Anomalous Transport Simulation of Ion and Electron Distributions

    SciTech Connect

    Harvey, R. W.; Petrov, Yu. V.

    2013-12-03

    Within the US Department of Energy/Office of Fusion Energy magnetic fusion research program, there is an important whole-plasma-modeling need for a radio-frequency/neutral-beam-injection (RF/NBI) transport-oriented finite-difference Fokker-Planck (FP) code with combined capabilities for 4D (2R2V) geometry near the fusion plasma periphery, and computationally less demanding 3D (1R2V) bounce-averaged capabilities for plasma in the core of fusion devices. Demonstration of proof-of-principle achievement of this goal has been carried out in research carried out under Phase I of the SBIR award. Two DOE-sponsored codes, the CQL3D bounce-average Fokker-Planck code in which CompX has specialized, and the COGENT 4D, plasma edge-oriented Fokker-Planck code which has been constructed by Lawrence Livermore National Laboratory and Lawrence Berkeley Laboratory scientists, where coupled. Coupling was achieved by using CQL3D calculated velocity distributions including an energetic tail resulting from NBI, as boundary conditions for the COGENT code over the two-dimensional velocity space on a spatial interface (flux) surface at a given radius near the plasma periphery. The finite-orbit-width fast ions from the CQL3D distributions penetrated into the peripheral plasma modeled by the COGENT code. This combined code demonstrates the feasibility of the proposed 3D/4D code. By combining these codes, the greatest computational efficiency is achieved subject to present modeling needs in toroidally symmetric magnetic fusion devices. The more efficient 3D code can be used in its regions of applicability, coupled to the more computationally demanding 4D code in higher collisionality edge plasma regions where that extended capability is necessary for accurate representation of the plasma. More efficient code leads to greater use and utility of the model. An ancillary aim of the project is to make the combined 3D/4D code user friendly. Achievement of full-coupling of these two Fokker-Planck

  20. Dynamically accumulated dose and 4D accumulated dose for moving tumors

    SciTech Connect

    Li Heng; Li Yupeng; Zhang Xiaodong; Li Xiaoqiang; Liu Wei; Gillin, Michael T.; Zhu, X. Ronald

    2012-12-15

    Purpose: The purpose of this work was to investigate the relationship between dynamically accumulated dose (dynamic dose) and 4D accumulated dose (4D dose) for irradiation of moving tumors, and to quantify the dose uncertainty induced by tumor motion. Methods: The authors established that regardless of treatment modality and delivery properties, the dynamic dose will converge to the 4D dose, instead of the 3D static dose, after multiple deliveries. The bounds of dynamic dose, or the maximum estimation error using 4D or static dose, were established for the 4D and static doses, respectively. Numerical simulations were performed (1) to prove the principle that for each phase, after multiple deliveries, the average number of deliveries for any given time converges to the total number of fractions (K) over the number of phases (N); (2) to investigate the dose difference between the 4D and dynamic doses as a function of the number of deliveries for deliveries of a 'pulsed beam'; and (3) to investigate the dose difference between 4D dose and dynamic doses as a function of delivery time for deliveries of a 'continuous beam.' A Poisson model was developed to estimate the mean dose error as a function of number of deliveries or delivered time for both pulsed beam and continuous beam. Results: The numerical simulations confirmed that the number of deliveries for each phase converges to K/N, assuming a random starting phase. Simulations for the pulsed beam and continuous beam also suggested that the dose error is a strong function of the number of deliveries and/or total deliver time and could be a function of the breathing cycle, depending on the mode of delivery. The Poisson model agrees well with the simulation. Conclusions: Dynamically accumulated dose will converge to the 4D accumulated dose after multiple deliveries, regardless of treatment modality. Bounds of the dynamic dose could be determined using quantities derived from 4D doses, and the mean dose difference

  1. Low external pH replaces 2,4-D in maintaining and multiplying 2,4-D-initiated embryogenic cells of carrot

    NASA Technical Reports Server (NTRS)

    Smith, D. L.; Krikorian, A. D.

    1990-01-01

    A mixed culture comprised of both embryonic globules and nonembryogenic callus was derived from seedling hypocotyls of Daucus carota cv. Scarlet Nantes on 2,4-D- containing medium using well-established methods. Then the mixed cultures were transferred to, and serially subcultured on, a hormone-free medium near pH 4. The medium contained 1 mM NH4+ as the sole nitrogen source. When cultured in this way, embryonic globules were able to multiply without development into later embryo stages. Nonembryogenic callus did not survive. Continuous culture of embryonic globules on this low pH hormone-free medium yielded cultures consisting entirely of preglobular stage proembryos (PGSPs). PGSP cultures have been maintained as such with continuous multiplication for nearly 2 years without loss of embryogenic potential. These hormone-free-maintained PGSPs continue their development to later embryo stages when cultured on the same hormone-free medium buffered at pH 5.8. We show that hormone-free medium near pH 4 can replace 2,4-D in its ability to sustain multiplication of 2,4-D-initiated embryogenic cells of carrot at an acceptable growth rate without their development into later embryo stages. This procedure provides selective conditions that do not permit the growth of non-embryogenic cells while providing an adequate environment for embryogenic cell proliferation and should prove invaluable in studying habituation.

  2. 2,4-D toxicosis.III: An attempt to produce 2,4-D toxicosis in dogs on treated grass plots.

    PubMed

    Arnold, E K; Lovell, R A; Beasley, V R; Parker, A J; Stedelin, J R

    1991-10-01

    Eighteen English pointer dogs were randomly assigned to 3 outdoor grass-plot enclosures (6/enclosure) uniformly sprayed once with either the 2,4-dichlorophenoxyacetic acid (2,4-D) dimethylamine formulation (DMA-4) at the maximum recommended application rate, DMA-4 at 4 times the maximum recommended application rate, or the DMA-4 vehicle alone at 4 times the maximum recommended application rate. A heavy rain shower occurred 24 h after application. The dogs were observed for clinical signs and evaluated using an electroencephalograph, electrocardiograph (lead I), and electromyograph prior to exposure, and either 1 or 7 d after continuous exposure. Clinical examination, hematologic and serum biochemical data were obtained, and serum, urine and kidney 2,4-D were quantified. Half of the dogs from each group were killed after 1 d of continuous exposure, while the other half were killed after 7 d. Gross postmortem and histologic examinations were conducted on each dog. No obvious 2,4-D effects were detected in any of the dogs.

  3. Evaluation of a 4D cone-beam CT reconstruction approach using a simulation framework.

    PubMed

    Hartl, Alexander; Yaniv, Ziv

    2009-01-01

    Current image-guided navigation systems for thoracic abdominal interventions utilize three dimensional (3D) images acquired at breath-hold. As a result they can only provide guidance at a specific point in the respiratory cycle. The intervention is thus performed in a gated manner, with the physician advancing only when the patient is at the same respiratory cycle in which the 3D image was acquired. To enable a more continuous workflow we propose to use 4D image data. We describe an approach to constructing a set of 4D images from a diagnostic CT acquired at breath-hold and a set of intraoperative cone-beam CT (CBCT) projection images acquired while the patient is freely breathing. Our approach is based on an initial reconstruction of a gated 4D CBCT data set. The 3D CBCT images for each respiratory phase are then non-rigidly registered to the diagnostic CT data. Finally the diagnostic CT is deformed based on the registration results, providing a 4D data set with sufficient quality for navigation purposes. In this work we evaluate the proposed reconstruction approach using a simulation framework. A 3D CBCT dataset of an anthropomorphic phantom is deformed using internal motion data acquired from an animal model to create a ground truth 4D CBCT image. Simulated projection images are then created from the 4D image and the known CBCT scan parameters. Finally, the original 3D CBCT and the simulated X-ray images are used as input to our reconstruction method. The resulting 4D data set is then compared to the known ground truth by normalized cross correlation(NCC). We show that the deformed diagnostic CTs are of better quality than the gated reconstructions with a mean NCC value of 0.94 versus a mean 0.81 for the reconstructions. PMID:19964143

  4. Capillary Deposition of Complement C4d and C3d in Chinese Renal Allograft Biopsies

    PubMed Central

    Lv, Rong; Zhang, Wei; Han, Fei; Liu, Guangjun; Xie, Wenqing

    2015-01-01

    Background. C3d is a product of both the classic and the alternative complement cascades; however, few studies have addressed the role of C3d in renal biopsies and its relationship with long-term graft survival rate is not very clear. Methods. 94 patients with biopsy-proven acute rejection episodes were included in the study. We investigated the associations between histological findings, clinical examinations, and outcome. Results. The overall prevalence for C4dPTC and C3dPTC was 42.6% and 29.8%. There was a significant association between C3dPTC and C4dPTC (P < 0.001). C3dPTC and C4dPTC were related with histological types (P = 0.024 and P < 0.001, resp.). The long-term survival rate for C4dPTC positive transplants was lower than that of C4dPTC negative transplants, but it was not statistic significant in our study (P = 0.150). The survival rate of C3dPTC positive group was much lower than the negative group (P = 0.014). Patients with double positives for C4dPTC and C3dPTC exhibited the lowest survival rate significantly different from those of the C3dPTC only and C4dPTC only groups (P = 0.01 and P = 0.0037). Conclusions. This longitudinal cohort study has demonstrated that C3d deposition in the PTC was closely related to renal dysfunction and pathological changes. PMID:25821339

  5. Evaluation of 4D CT acquisition methods designed to reduce artifacts.

    PubMed

    Castillo, Sarah J; Castillo, Richard; Castillo, Edward; Pan, Tinsu; Ibbott, Geoffrey; Balter, Peter; Hobbs, Brian; Guerrero, Thomas

    2015-03-08

    Four-dimensional computed tomography (4D CT) is used to account for respiratory motion in radiation treatment planning, but artifacts resulting from the acquisition and postprocessing limit its accuracy. We investigated the efficacy of three experimental 4D CT acquisition methods to reduce artifacts in a prospective institutional review board approved study. Eighteen thoracic patients scheduled to undergo radiation therapy received standard clinical 4D CT scans followed by each of the alternative 4D CT acquisitions: 1) data oversampling, 2) beam gating with breathing irregularities, and 3) rescanning the clinical acquisition acquired during irregular breathing. Relative values of a validated correlation-based artifact metric (CM) determined the best acquisition method per patient. Each 4D CT was processed by an extended phase sorting approach that optimizes the quantitative artifact metric (CM sorting). The clinical acquisitions were also postprocessed by phase sorting for artifact comparison of our current clinical implementation with the experimental methods. The oversampling acquisition achieved the lowest artifact presence among all acquisitions, achieving a 27% reduction from the current clinical 4D CT implementation (95% confidence interval = 34-20). The rescan method presented a significantly higher artifact presence from the clinical acquisition (37%; p < 0.002), the gating acquisition (26%; p < 0.005), and the oversampling acquisition (31%; p < 0.001), while the data lacked evidence of a significant difference between the clinical, gating, and oversampling methods. The oversampling acquisition reduced artifact presence from the current clinical 4D CT implementation to the largest degree and provided the simplest and most reproducible implementation. The rescan acquisition increased artifact presence significantly, compared to all acquisitions, and suffered from combination of data from independent scans over which large internal anatomic shifts occurred.

  6. 4D optimization of scanned ion beam tracking therapy for moving tumors

    NASA Astrophysics Data System (ADS)

    Eley, John Gordon; Newhauser, Wayne David; Lüchtenborg, Robert; Graeff, Christian; Bert, Christoph

    2014-07-01

    Motion mitigation strategies are needed to fully realize the theoretical advantages of scanned ion beam therapy for patients with moving tumors. The purpose of this study was to determine whether a new four-dimensional (4D) optimization approach for scanned-ion-beam tracking could reduce dose to avoidance volumes near a moving target while maintaining target dose coverage, compared to an existing 3D-optimized beam tracking approach. We tested these approaches computationally using a simple 4D geometrical phantom and a complex anatomic phantom, that is, a 4D computed tomogram of the thorax of a lung cancer patient. We also validated our findings using measurements of carbon-ion beams with a motorized film phantom. Relative to 3D-optimized beam tracking, 4D-optimized beam tracking reduced the maximum predicted dose to avoidance volumes by 53% in the simple phantom and by 13% in the thorax phantom. 4D-optimized beam tracking provided similar target dose homogeneity in the simple phantom (standard deviation of target dose was 0.4% versus 0.3%) and dramatically superior homogeneity in the thorax phantom (D5-D95 was 1.9% versus 38.7%). Measurements demonstrated that delivery of 4D-optimized beam tracking was technically feasible and confirmed a 42% decrease in maximum film exposure in the avoidance region compared with 3D-optimized beam tracking. In conclusion, we found that 4D-optimized beam tracking can reduce the maximum dose to avoidance volumes near a moving target while maintaining target dose coverage, compared with 3D-optimized beam tracking.

  7. Resolution enhancement of lung 4D-CT data using multiscale interphase iterative nonlocal means

    SciTech Connect

    Zhang Yu; Yap, Pew-Thian; Wu Guorong; Feng Qianjin; Chen Wufan; Lian Jun; Shen Dinggang

    2013-05-15

    Purpose: Four-dimensional computer tomography (4D-CT) has been widely used in lung cancer radiotherapy due to its capability in providing important tumor motion information. However, the prolonged scanning duration required by 4D-CT causes considerable increase in radiation dose. To minimize the radiation-related health risk, radiation dose is often reduced at the expense of interslice spatial resolution. However, inadequate resolution in 4D-CT causes artifacts and increases uncertainty in tumor localization, which eventually results in extra damages of healthy tissues during radiotherapy. In this paper, the authors propose a novel postprocessing algorithm to enhance the resolution of lung 4D-CT data. Methods: The authors' premise is that anatomical information missing in one phase can be recovered from the complementary information embedded in other phases. The authors employ a patch-based mechanism to propagate information across phases for the reconstruction of intermediate slices in the longitudinal direction, where resolution is normally the lowest. Specifically, the structurally matching and spatially nearby patches are combined for reconstruction of each patch. For greater sensitivity to anatomical details, the authors employ a quad-tree technique to adaptively partition the image for more fine-grained refinement. The authors further devise an iterative strategy for significant enhancement of anatomical details. Results: The authors evaluated their algorithm using a publicly available lung data that consist of 10 4D-CT cases. The authors' algorithm gives very promising results with significantly enhanced image structures and much less artifacts. Quantitative analysis shows that the authors' algorithm increases peak signal-to-noise ratio by 3-4 dB and the structural similarity index by 3%-5% when compared with the standard interpolation-based algorithms. Conclusions: The authors have developed a new algorithm to improve the resolution of 4D-CT. It outperforms

  8. The Use of Gated and 4D CT Imaging in Planning for Stereotactic Body Radiation Therapy

    SciTech Connect

    D'Souza, Warren D. . E-mail: wdsou001@umaryland.edu; Nazareth, Daryl P.; Zhang Bin; Deyoung, Chad; Suntharalingam, Mohan; Kwok, Young; Yu, Cedric X.; Regine, William F.

    2007-07-01

    The localization of treatment targets is of utmost importance for patients receiving stereotactic body radiation therapy (SBRT), where the dose per fraction is large. While both setup or respiration-induced motion components affect the localization of the treatment volume, the purpose of this work is to describe our management of the intrafraction localization uncertainty induced by normal respiration. At our institution, we have implemented gated computed tomography (CT) acquisition with an active breathing control system (ABC), and 4-dimensional (4D) CT using a skin-based marker and retrospective respiration phase-based image sorting. During gated simulation, 3D CT images were acquired corresponding to end-inhalation and end-exhalation. For 4D CT imaging, 3D CT images were acquired corresponding to 8 phases of the respiratory cycle. In addition to gated or 4D CT images, we acquired a conventional free-breathing CT (FB). For both gated and 4D CT images, the target contours were registered to the FB scan in the planning system. These contours were then combined in the FB image set to form the internal target volume (ITV). Dynamic conformal arc treatment plans were generated for the ITV using the FB scan and the gated or 4D scans with an additional 7-mm margin for patient setup uncertainty. We have described our results for a pancreas and a lung tumor case. Plans were normalized so that the PTV received 95% of the prescription dose. The dose distribution for all the critical structures in the pancreas and lung tumor cases resulted in increased sparing when the ITV was defined using gated or 4D CT images than when the FB scan was used. Our results show that patient-specific target definition using gated or 4D CT scans lead to improved normal tissue sparing.

  9. Isolation and 2,4-D-degrading characteristics of Cupriavidus campinensis BJ71

    PubMed Central

    Han, Lizhen; Zhao, Degang; Li, Cuicui

    2015-01-01

    An indigenous bacterial strain capable of utilizing 2,4-dichlorophenoxyacetic acid as the sole carbon and energy source was isolated from a soil used for grown wheat with a long-term history of herbicide use in Beijing, China. The strain BJ71 was identified as Cupriavidus campinensis based on its 16S rRNA sequence analysis and morphological, physiological, and biochemical characteristics. The degradation characteristics of strain BJ71 were evaluated. The optimal conditions for 2,4-D degradation were as follows: pH 7.0, 30 °C, 3% (v/v) inoculum size, and an initial 2,4-D concentration of 350 mg L−1. Up to 99.57% of the 2,4-D was degraded under optimal conditions after 6 days of incubation. Strain BJ71 was also able to degrade quizalofop and fluroxypyr. This is the first report of a 2,4-D-degrader containing tfdA gene that can utilize these two herbicides. In a biodegradation experiment, 87.13% and 42.53% of 2,4-D (initial concentration, 350 mg kg−1) was degraded in non-sterile and sterilized soil inoculated with BJ71, respectively, after 14 days. The 2,4-D degradation was more rapid in a soil microcosm including BJ71 than in a soil microcosm without BJ71. These results indicate that strain BJ71 is a potential candidate for the bioremediation of soil contaminated with the herbicide 2,4-D. PMID:26273258

  10. Evaluation of Fractional Regional Ventilation Using 4D-CT and Effects of Breathing Maneuvers on Ventilation

    SciTech Connect

    Mistry, Nilesh N.; Diwanji, Tejan; Shi, Xiutao; Pokharel, Sabin; Feigenberg, Steven; Scharf, Steven M.; D'Souza, Warren D.

    2013-11-15

    Purpose: Current implementations of methods based on Hounsfield units to evaluate regional lung ventilation do not directly incorporate tissue-based mass changes that occur over the respiratory cycle. To overcome this, we developed a 4-dimensional computed tomography (4D-CT)-based technique to evaluate fractional regional ventilation (FRV) that uses an individualized ratio of tidal volume to end-expiratory lung volume for each voxel. We further evaluated the effect of different breathing maneuvers on regional ventilation. The results from this work will help elucidate the relationship between global and regional lung function. Methods and Materials: Eight patients underwent 3 sets of 4D-CT scans during 1 session using free-breathing, audiovisual guidance, and active breathing control. FRV was estimated using a density-based algorithm with mass correction. Internal validation between global and regional ventilation was performed by use of the imaging data collected during the use of active breathing control. The impact of breathing maneuvers on FRV was evaluated comparing the tidal volume from 3 breathing methods. Results: Internal validation through comparison between the global and regional changes in ventilation revealed a strong linear correlation (slope of 1.01, R{sup 2} of 0.97) between the measured global lung volume and the regional lung volume calculated by use of the “mass corrected” FRV. A linear relationship was established between the tidal volume measured with the automated breathing control system and FRV based on 4D-CT imaging. Consistently larger breathing volumes were observed when coached breathing techniques were used. Conclusions: The technique presented improves density-based evaluation of lung ventilation and establishes a link between global and regional lung ventilation volumes. Furthermore, the results obtained are comparable with those of other techniques of functional evaluation such as spirometry and hyperpolarized-gas magnetic

  11. AZTECAN C3PO: Arizona Three-millimeter Educational C18O And N2H+ Cold Core Census of Planck Objects

    NASA Astrophysics Data System (ADS)

    Walker-LaFollette, Amanda; Shirley, Y. L.; Hardegree-Ullman, K. K.; Towner, A. P. M.; Wallace, S. C.; Smith, C. W.; Turner, J. D.; Robertson, A. N.; Austin, C. L.; Small, L. C.; Carleton, T. M.; McGraw, A. M.; Daugherty, M. J.; Guvenen, B. C.; Johnson, K. L.; Crawford, B. E.; Smart, B. M.

    2012-05-01

    The Planck satellite is studying the power spectrum of the Cosmic Microwave Background (CMB), and has found foreground contamination including dust emission from the Galaxy. The Planck Cold Core Team has been cataloging and characterizing this foreground emission. An initial catalog of over 10,000 objects, the Cold Core Census of Planck Objects (C3PO), was released from the first year of data. A subset of 915 cold cores with dust temperatures of Td < 14K and SNR > 15 was selected from this catalog, and called the Early Cold Core (ECC) Catalog. Ground-based follow-up observations of these cores are needed to determine their size, mass, source geometry (filamentary, multiple cores, etc.), and kinematic properties (degree of turbulence, etc.). Using the Arizona Radio Observatory 12m radio telescope, we mapped a sub-sample of the ECC at 1‧ resolution in the dense gas tracers C18O J=1-0 and N2H+ J=1-0. These tracers complement each other, with CO depleting in very cold, dense environments where N2H+ may be abundant. While we detected most of the cores observed in C18O, we find that N2H+ emission is very weak toward many Planck cold cores. We present here the initial results from our mapping survey. This project is the main component of Amanda Walker-LaFollette’s NASA Space Grant internship research.

  12. A deformable phantom for 4D radiotherapy verification: Design and image registration evaluation

    SciTech Connect

    Serban, Monica; Heath, Emily; Stroian, Gabriela; Collins, D. Louis; Seuntjens, Jan

    2008-03-15

    peak inhale. The SI displacement of the landmarks varied between 94% and 3% of the piston excursion for positions closer and farther away from the piston, respectively. The reproducibility of the phantom deformation was within the image resolution (0.7x0.7x1.25 mm{sup 3}). Vector average registration accuracy based on point landmarks was found to be 0.5 (0.4 SD) mm. The tumor and lung mean 3D DTA obtained from triangulated surfaces were 0.4 (0.1 SD) mm and 1.0 (0.8 SD) mm, respectively. This phantom is capable of reproducibly emulating the physically realistic lung features and deformations and has a wide range of potential applications, including four-dimensional (4D) imaging, evaluation of deformable registration accuracy, 4D planning and dose delivery.

  13. Cloning and expression of the 4D8 gene from Hyalomma asiaticum tick.

    PubMed

    Liu, Z Q; Xia, J; Wang, G L; Kuermanali, N

    2016-01-01

    Hyalomma asiaticum tick, an important ectozoic parasite causes tickle, pain, anemia, weight loss, and paralysis in its hosts, which include humans, cattle, sheep, horses, camels, and hares. The 4D8 gene can be a potential vaccine candidate antigen for H. asiaticum. In the present study, we cloned and expressed the 4D8 gene of H. asiaticum from Xinjiang Province. Primers were designed according to the H. asiaticum tick 4D8 gene sequence available in GenBank. The gene was amplified by reverse transcription-polymerase chain reaction and the fragments were subcloned into the prokaryotic expression vector pET30a and the recombinant vector pET30a-4D8 was constructed. The expressed recombinant protein was purified and its biological activity was investigated by western blot. Results revealed that the recombinant protein was a biologically active fusion protein with a molecular weight of 20 kDa. The purified 4D8 protein would provide a strong foundation for further studies on this protein. PMID:27323189

  14. 4D cone-beam CT reconstruction using multi-organ meshes for sliding motion modeling.

    PubMed

    Zhong, Zichun; Gu, Xuejun; Mao, Weihua; Wang, Jing

    2016-02-01

    A simultaneous motion estimation and image reconstruction (SMEIR) strategy was proposed for 4D cone-beam CT (4D-CBCT) reconstruction and showed excellent results in both phantom and lung cancer patient studies. In the original SMEIR algorithm, the deformation vector field (DVF) was defined on voxel grid and estimated by enforcing a global smoothness regularization term on the motion fields. The objective of this work is to improve the computation efficiency and motion estimation accuracy of SMEIR for 4D-CBCT through developing a multi-organ meshing model. Feature-based adaptive meshes were generated to reduce the number of unknowns in the DVF estimation and accurately capture the organ shapes and motion. Additionally, the discontinuity in the motion fields between different organs during respiration was explicitly considered in the multi-organ mesh model. This will help with the accurate visualization and motion estimation of the tumor on the organ boundaries in 4D-CBCT. To further improve the computational efficiency, a GPU-based parallel implementation was designed. The performance of the proposed algorithm was evaluated on a synthetic sliding motion phantom, a 4D NCAT phantom, and four lung cancer patients. The proposed multi-organ mesh based strategy outperformed the conventional Feldkamp-Davis-Kress, iterative total variation minimization, original SMEIR and single meshing method based on both qualitative and quantitative evaluations.

  15. Identification of novel mutations confirms PDE4D as a major gene causing acrodysostosis.

    PubMed

    Lynch, Danielle C; Dyment, David A; Huang, Lijia; Nikkel, Sarah M; Lacombe, Didier; Campeau, Philippe M; Lee, Brendan; Bacino, Carlos A; Michaud, Jacques L; Bernier, Francois P; Parboosingh, Jillian S; Innes, A Micheil

    2013-01-01

    Acrodysostosis is characterized by nasal hypoplasia, peripheral dysostosis, variable short stature, and intellectual impairment. Recently, mutations in PRKAR1A were reported in patients with acrodysostosis and hormone resistance. Subsequently, mutations in a phosphodiesterase gene (PDE4D) were identified in seven sporadic cases. We sequenced PDE4D in seven acrodysostosis patients from five families. Missense mutations were identified in all cases. Families showed de novo inheritance except one family with three affected children whose father was subsequently found to have subtle features of acrodysostosis. There were no recurrent mutations. Short stature and endocrine resistance are rare in this series; however, cognitive involvement and obesity were frequent. This last finding is relevant given PDE4D is insulin responsive and potentially involved in lipolysis. PDE4D encodes a cyclic AMP regulator and places PDE4D-related acrodysostosis within the same family of diseases as pseudohypoparathyroidism, pseudopseudohypoparathyroidism, PRKAR1A-related acrodysostosis and brachydactyly-mental retardation syndrome; all characterized by cognitive impairment and short distal extremities. PMID:23033274

  16. Improvement of the cine-CT based 4D-CT imaging

    SciTech Connect

    Pan Tinsu; Sun Xiaojun; Luo Dershan

    2007-11-15

    An improved 4D-CT utility has been developed on the GE LightSpeed multislice CT (MSCT) and Discovery PET/CT scanners, which have the cine CT scan capability. Two new features have been added in this 4D-CT over the commercial Advantage 4D-CT from GE. One feature was a new tool for disabling parts of the respiratory signal with irregular respiration and improving the accuracy of phase determination for the respiratory signal from the Varian real-time positioning and monitoring (RPM) system before sorting of the cine CT images into the 4D-CT images. The second feature was to allow generation of the maximum-intensity-projection (MIP), average (AVG) and minimum-intensity-projection (mip) CT images from the cine CT images without a respiratory signal. The implementation enables the assessment of tumor motion in treatment planning with the MIP, AVG, and mip CT images on the GE MSCT and PET/CT scanners without the RPM and the Advantage 4D-CT with a GE Advantage windows workstation. Several clinical examples are included to illustrate this new application.

  17. Review of 2,4-dichlorophenoxyacetic acid (2,4-D) biomonitoring and epidemiology

    PubMed Central

    Burns, Carol J.; Swaen, Gerard M. H.

    2012-01-01

    A qualitative review of the epidemiological literature on the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) and health after 2001 is presented. In order to compare the exposure of the general population, bystanders and occupational groups, their urinary levels were also reviewed. In the general population, 2,4-D exposure is at or near the level of detection (LOD). Among individuals with indirect exposure, i.e. bystanders, the urinary 2,4-D levels were also very low except in individuals with opportunity for direct contact with the herbicide. Occupational exposure, where exposure was highest, was positively correlated with behaviors related to the mixing, loading and applying process and use of personal protection. Information from biomonitoring studies increases our understanding of the validity of the exposure estimates used in epidemiology studies. The 2,4-D epidemiology literature after 2001 is broad and includes studies of cancer, reproductive toxicity, genotoxicity, and neurotoxicity. In general, a few publications have reported statistically significant associations. However, most lack precision and the results are not replicated in other independent studies. In the context of biomonitoring, the epidemiology data give no convincing or consistent evidence for any chronic adverse effect of 2,4-D in humans. PMID:22876750

  18. Impact of 4D image quality on the accuracy of target definition.

    PubMed

    Nielsen, Tine Bjørn; Hansen, Christian Rønn; Westberg, Jonas; Hansen, Olfred; Brink, Carsten

    2016-03-01

    Delineation accuracy of target shape and position depends on the image quality. This study investigates whether the image quality on standard 4D systems has an influence comparable to the overall delineation uncertainty. A moving lung target was imaged using a dynamic thorax phantom on three different 4D computed tomography (CT) systems and a 4D cone beam CT (CBCT) system using pre-defined clinical scanning protocols. Peak-to-peak motion and target volume were registered using rigid registration and automatic delineation, respectively. A spatial distribution of the imaging uncertainty was calculated as the distance deviation between the imaged target and the true target shape. The measured motions were smaller than actual motions. There were volume differences of the imaged target between respiration phases. Imaging uncertainties of >0.4 cm were measured in the motion direction which showed that there was a large distortion of the imaged target shape. Imaging uncertainties of standard 4D systems are of similar size as typical GTV-CTV expansions (0.5-1 cm) and contribute considerably to the target definition uncertainty. Optimising and validating 4D systems is recommended in order to obtain the most optimal imaged target shape.

  19. Hydrophobic metabolites of 2,4-dichlorophenoxyacetic acid (2,4-D) in cultured coconut tissue.

    PubMed

    López-Villalobos, Arturo; Hornung, Roland; Dodds, Peter F

    2004-10-01

    Cultures of inflorescence and plumular tissues of coconut palm (Cocos nucifera L.) were maintained in the presence of the auxin, [14C]2,4-dichlorophenoxyacetic acid (2,4-D), so that its metabolic fate could be studied. Thin layer chromatography of methanol extracts of the plumular tissue showed that four classes of metabolites, as well as the unchanged acid, were recovered in the extract. In inflorescence tissue, only the unchanged acid and the most polar class of metabolites (metabolite I) were recovered. Metabolite I was shown to consist mostly of a mixture of sugar conjugates and metabolite II (the next most polar) was an unidentified basic metabolite. Metabolites III and IV were both novel triacylglycerol analogues in which one of the natural fatty acids was replaced with a chain-elongated form of 2,4-D. Reversed-phase thin layer chromatography was used to identify the 2,4-D-derived acids and it was found that metabolite III contained the 2,4-dichlorophenoxy-moiety attached to a chain-length of between 2 and 12 carbons, whereas metabolite IV contained 12, 14 and 16 carbon chain lengths. In inflorescence tissue, and in plumular tissue at low sucrose or 2,4-D concentrations and after short periods in culture, metabolite I predominated. The other metabolites increased as a percentage when plumular culture was prolonged or when sucrose or 2,4-D concentrations were raised. These changes correlated with better development of the explant.

  20. Allowing for model error in strong constraint 4D-Var

    NASA Astrophysics Data System (ADS)

    Howes, Katherine; Lawless, Amos; Fowler, Alison

    2016-04-01

    Four dimensional variational data assimilation (4D-Var) can be used to obtain the best estimate of the initial conditions of an environmental forecasting model, namely the analysis. In practice, when the forecasting model contains errors, the analysis from the 4D-Var algorithm will be degraded to allow for errors later in the forecast window. This work focusses on improving the analysis at the initial time by allowing for the fact that the model contains error, within the context of strong constraint 4D-Var. The 4D-Var method developed acknowledges the presence of random error in the model at each time step by replacing the observation error covariance matrix with an error covariance matrix that includes both observation error and model error statistics. It is shown that this new matrix represents the correct error statistics of the innovations in the presence of model error. A method for estimating this matrix using innovation statistics, without requiring prior knowledge of the model error statistics, is presented. The method is demonstrated numerically using a non-linear chaotic system with erroneous parameter values. We show that that the new method works to reduce the analysis error covariance when compared with a standard strong constraint 4D-Var scheme. We discuss the fact that an improved analysis will not necessarily provide a better forecast.

  1. Review of 2,4-dichlorophenoxyacetic acid (2,4-D) biomonitoring and epidemiology.

    PubMed

    Burns, Carol J; Swaen, Gerard M H

    2012-10-01

    A qualitative review of the epidemiological literature on the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) and health after 2001 is presented. In order to compare the exposure of the general population, bystanders and occupational groups, their urinary levels were also reviewed. In the general population, 2,4-D exposure is at or near the level of detection (LOD). Among individuals with indirect exposure, i.e. bystanders, the urinary 2,4-D levels were also very low except in individuals with opportunity for direct contact with the herbicide. Occupational exposure, where exposure was highest, was positively correlated with behaviors related to the mixing, loading and applying process and use of personal protection. Information from biomonitoring studies increases our understanding of the validity of the exposure estimates used in epidemiology studies. The 2,4-D epidemiology literature after 2001 is broad and includes studies of cancer, reproductive toxicity, genotoxicity, and neurotoxicity. In general, a few publications have reported statistically significant associations. However, most lack precision and the results are not replicated in other independent studies. In the context of biomonitoring, the epidemiology data give no convincing or consistent evidence for any chronic adverse effect of 2,4-D in humans.

  2. 4D cone-beam CT reconstruction using multi-organ meshes for sliding motion modeling

    NASA Astrophysics Data System (ADS)

    Zhong, Zichun; Gu, Xuejun; Mao, Weihua; Wang, Jing

    2016-02-01

    A simultaneous motion estimation and image reconstruction (SMEIR) strategy was proposed for 4D cone-beam CT (4D-CBCT) reconstruction and showed excellent results in both phantom and lung cancer patient studies. In the original SMEIR algorithm, the deformation vector field (DVF) was defined on voxel grid and estimated by enforcing a global smoothness regularization term on the motion fields. The objective of this work is to improve the computation efficiency and motion estimation accuracy of SMEIR for 4D-CBCT through developing a multi-organ meshing model. Feature-based adaptive meshes were generated to reduce the number of unknowns in the DVF estimation and accurately capture the organ shapes and motion. Additionally, the discontinuity in the motion fields between different organs during respiration was explicitly considered in the multi-organ mesh model. This will help with the accurate visualization and motion estimation of the tumor on the organ boundaries in 4D-CBCT. To further improve the computational efficiency, a GPU-based parallel implementation was designed. The performance of the proposed algorithm was evaluated on a synthetic sliding motion phantom, a 4D NCAT phantom, and four lung cancer patients. The proposed multi-organ mesh based strategy outperformed the conventional Feldkamp-Davis-Kress, iterative total variation minimization, original SMEIR and single meshing method based on both qualitative and quantitative evaluations.

  3. Identification of novel mutations confirms PDE4D as a major gene causing acrodysostosis.

    PubMed

    Lynch, Danielle C; Dyment, David A; Huang, Lijia; Nikkel, Sarah M; Lacombe, Didier; Campeau, Philippe M; Lee, Brendan; Bacino, Carlos A; Michaud, Jacques L; Bernier, Francois P; Parboosingh, Jillian S; Innes, A Micheil

    2013-01-01

    Acrodysostosis is characterized by nasal hypoplasia, peripheral dysostosis, variable short stature, and intellectual impairment. Recently, mutations in PRKAR1A were reported in patients with acrodysostosis and hormone resistance. Subsequently, mutations in a phosphodiesterase gene (PDE4D) were identified in seven sporadic cases. We sequenced PDE4D in seven acrodysostosis patients from five families. Missense mutations were identified in all cases. Families showed de novo inheritance except one family with three affected children whose father was subsequently found to have subtle features of acrodysostosis. There were no recurrent mutations. Short stature and endocrine resistance are rare in this series; however, cognitive involvement and obesity were frequent. This last finding is relevant given PDE4D is insulin responsive and potentially involved in lipolysis. PDE4D encodes a cyclic AMP regulator and places PDE4D-related acrodysostosis within the same family of diseases as pseudohypoparathyroidism, pseudopseudohypoparathyroidism, PRKAR1A-related acrodysostosis and brachydactyly-mental retardation syndrome; all characterized by cognitive impairment and short distal extremities.

  4. Hydrophobic metabolites of 2,4-dichlorophenoxyacetic acid (2,4-D) in cultured coconut tissue.

    PubMed

    López-Villalobos, Arturo; Hornung, Roland; Dodds, Peter F

    2004-10-01

    Cultures of inflorescence and plumular tissues of coconut palm (Cocos nucifera L.) were maintained in the presence of the auxin, [14C]2,4-dichlorophenoxyacetic acid (2,4-D), so that its metabolic fate could be studied. Thin layer chromatography of methanol extracts of the plumular tissue showed that four classes of metabolites, as well as the unchanged acid, were recovered in the extract. In inflorescence tissue, only the unchanged acid and the most polar class of metabolites (metabolite I) were recovered. Metabolite I was shown to consist mostly of a mixture of sugar conjugates and metabolite II (the next most polar) was an unidentified basic metabolite. Metabolites III and IV were both novel triacylglycerol analogues in which one of the natural fatty acids was replaced with a chain-elongated form of 2,4-D. Reversed-phase thin layer chromatography was used to identify the 2,4-D-derived acids and it was found that metabolite III contained the 2,4-dichlorophenoxy-moiety attached to a chain-length of between 2 and 12 carbons, whereas metabolite IV contained 12, 14 and 16 carbon chain lengths. In inflorescence tissue, and in plumular tissue at low sucrose or 2,4-D concentrations and after short periods in culture, metabolite I predominated. The other metabolites increased as a percentage when plumular culture was prolonged or when sucrose or 2,4-D concentrations were raised. These changes correlated with better development of the explant. PMID:15474562

  5. Investigation of the accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat kidneys.

    PubMed

    Aydin, Handan; Ozdemir, Nurullah; Uzunören, Nuray

    2005-10-01

    The accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) and its metabolite 2,4-dichlorophenol (2,4-DCP) in the kidneys of rats was investigated. Male and female Sprague-Dawley rats were given 2,4-D in drinking water and food for 30 days. Group A (control group) was fed a normal diet, Group B was fed 50 ppm 2,4-D in 15 g food, Group C received 100 ppm 2,4-D in 15 g food, Group D received 25 ppm 2,4-D in 15 ml drinking water and Group E was given 50 ppm 2,4-D in 15 ml of drinking water. Levels of 2,4-D and 2,4-DCP in kidneys were determined using high performance liquid chromatography (HPLC). It was observed that at low doses of 2,4-D, the metabolite, 2,4-DCP found in the kidneys.

  6. SU-E-J-246: A Deformation-Field Map Based Liver 4D CBCT Reconstruction Method Using Gold Nanoparticles as Constraints

    SciTech Connect

    Harris, W; Zhang, Y; Ren, L; Yin, F

    2014-06-01

    Purpose: To investigate the feasibility of using nanoparticle markers to validate liver tumor motion together with a deformation field map-based four dimensional (4D) cone-beam computed tomography (CBCT) reconstruction method. Methods: A technique for lung 4D-CBCT reconstruction has been previously developed using a deformation field map (DFM)-based strategy. In this method, each phase of the 4D-CBCT is considered as a deformation of a prior CT volume. The DFM is solved by a motion modeling and free-form deformation (MM-FD) technique, using a data fidelity constraint and the deformation energy minimization. For liver imaging, there is low contrast of a liver tumor in on-board projections. A validation of liver tumor motion using implanted gold nanoparticles, along with the MM-FD deformation technique is implemented to reconstruct onboard 4D CBCT liver radiotherapy images. These nanoparticles were placed around the liver tumor to reflect the tumor positions in both CT simulation and on-board image acquisition. When reconstructing each phase of the 4D-CBCT, the migrations of the gold nanoparticles act as a constraint to regularize the deformation field, along with the data fidelity and the energy minimization constraints. In this study, multiple tumor diameters and positions were simulated within the liver for on-board 4D-CBCT imaging. The on-board 4D-CBCT reconstructed by the proposed method was compared with the “ground truth” image. Results: The preliminary data, which uses reconstruction for lung radiotherapy suggests that the advanced reconstruction algorithm including the gold nanoparticle constraint will Resultin volume percentage differences (VPD) between lesions in reconstructed images by MM-FD and “ground truth” on-board images of 11.5% (± 9.4%) and a center of mass shift of 1.3 mm (± 1.3 mm) for liver radiotherapy. Conclusion: The advanced MM-FD technique enforcing the additional constraints from gold nanoparticles, results in improved accuracy

  7. Joint analysis of BICEP2/keck array and Planck Data.

    PubMed

    Ade, P A R; Aghanim, N; Ahmed, Z; Aikin, R W; Alexander, K D; Arnaud, M; Aumont, J; Baccigalupi, C; Banday, A J; Barkats, D; Barreiro, R B; Bartlett, J G; Bartolo, N; Battaner, E; Benabed, K; Benoît, A; Benoit-Lévy, A; Benton, S J; Bernard, J-P; Bersanelli, M; Bielewicz, P; Bischoff, C A; Bock, J J; Bonaldi, A; Bonavera, L; Bond, J R; Borrill, J; Bouchet, F R; Boulanger, F; Brevik, J A; Bucher, M; Buder, I; Bullock, E; Burigana, C; Butler, R C; Buza, V; Calabrese, E; Cardoso, J-F; Catalano, A; Challinor, A; Chary, R-R; Chiang, H C; Christensen, P R; Colombo, L P L; Combet, C; Connors, J; Couchot, F; Coulais, A; Crill, B P; Curto, A; Cuttaia, F; Danese, L; Davies, R D; Davis, R J; de Bernardis, P; de Rosa, A; de Zotti, G; Delabrouille, J; Delouis, J-M; Désert, F-X; Dickinson, C; Diego, J M; Dole, H; Donzelli, S; Doré, O; Douspis, M; Dowell, C D; Duband, L; Ducout, A; Dunkley, J; Dupac, X; Dvorkin, C; Efstathiou, G; Elsner, F; Enßlin, T A; Eriksen, H K; Falgarone, E; Filippini, J P; Finelli, F; Fliescher, S; Forni, O; Frailis, M; Fraisse, A A; Franceschi, E; Frejsel, A; Galeotta, S; Galli, S; Ganga, K; Ghosh, T; Giard, M; Gjerløw, E; Golwala, S R; González-Nuevo, J; Górski, K M; Gratton, S; Gregorio, A; Gruppuso, A; Gudmundsson, J E; Halpern, M; Hansen, F K; Hanson, D; Harrison, D L; Hasselfield, M; Helou, G; Henrot-Versillé, S; Herranz, D; Hildebrandt, S R; Hilton, G C; Hivon, E; Hobson, M; Holmes, W A; Hovest, W; Hristov, V V; Huffenberger, K M; Hui, H; Hurier, G; Irwin, K D; Jaffe, A H; Jaffe, T R; Jewell, J; Jones, W C; Juvela, M; Karakci, A; Karkare, K S; Kaufman, J P; Keating, B G; Kefeli, S; Keihänen, E; Kernasovskiy, S A; Keskitalo, R; Kisner, T S; Kneissl, R; Knoche, J; Knox, L; Kovac, J M; Krachmalnicoff, N; Kunz, M; Kuo, C L; Kurki-Suonio, H; Lagache, G; Lähteenmäki, A; Lamarre, J-M; Lasenby, A; Lattanzi, M; Lawrence, C R; Leitch, E M; Leonardi, R; Levrier, F; Lewis, A; Liguori, M; Lilje, P B; Linden-Vørnle, M; López-Caniego, M; Lubin, P M; Lueker, M; Macías-Pérez, J F; Maffei, B; Maino, D; Mandolesi, N; Mangilli, A; Maris, M; Martin, P G; Martínez-González, E; Masi, S; Mason, P; Matarrese, S; Megerian, K G; Meinhold, P R; Melchiorri, A; Mendes, L; Mennella, A; Migliaccio, M; Mitra, S; Miville-Deschênes, M-A; Moneti, A; Montier, L; Morgante, G; Mortlock, D; Moss, A; Munshi, D; Murphy, J A; Naselsky, P; Nati, F; Natoli, P; Netterfield, C B; Nguyen, H T; Nørgaard-Nielsen, H U; Noviello, F; Novikov, D; Novikov, I; O'Brient, R; Ogburn, R W; Orlando, A; Pagano, L; Pajot, F; Paladini, R; Paoletti, D; Partridge, B; Pasian, F; Patanchon, G; Pearson, T J; Perdereau, O; Perotto, L; Pettorino, V; Piacentini, F; Piat, M; Pietrobon, D; Plaszczynski, S; Pointecouteau, E; Polenta, G; Ponthieu, N; Pratt, G W; Prunet, S; Pryke, C; Puget, J-L; Rachen, J P; Reach, W T; Rebolo, R; Reinecke, M; Remazeilles, M; Renault, C; Renzi, A; Richter, S; Ristorcelli, I; Rocha, G; Rossetti, M; Roudier, G; Rowan-Robinson, M; Rubiño-Martín, J A; Rusholme, B; Sandri, M; Santos, D; Savelainen, M; Savini, G; Schwarz, R; Scott, D; Seiffert, M D; Sheehy, C D; Spencer, L D; Staniszewski, Z K; Stolyarov, V; Sudiwala, R; Sunyaev, R; Sutton, D; Suur-Uski, A-S; Sygnet, J-F; Tauber, J A; Teply, G P; Terenzi, L; Thompson, K L; Toffolatti, L; Tolan, J E; Tomasi, M; Tristram, M; Tucci, M; Turner, A D; Valenziano, L; Valiviita, J; Van Tent, B; Vibert, L; Vielva, P; Vieregg, A G; Villa, F; Wade, L A; Wandelt, B D; Watson, R; Weber, A C; Wehus, I K; White, M; White, S D M; Willmert, J; Wong, C L; Yoon, K W; Yvon, D; Zacchei, A; Zonca, A

    2015-03-13

    We report the results of a joint analysis of data from BICEP2/Keck Array and Planck. BICEP2 and Keck Array have observed the same approximately 400  deg^{2} patch of sky centered on RA 0 h, Dec. -57.5°. The combined maps reach a depth of 57 nK deg in Stokes Q and U in a band centered at 150 GHz. Planck has observed the full sky in polarization at seven frequencies from 30 to 353 GHz, but much less deeply in any given region (1.2  μK deg in Q and U at 143 GHz). We detect 150×353 cross-correlation in B modes at high significance. We fit the single- and cross-frequency power spectra at frequencies ≥150  GHz to a lensed-ΛCDM model that includes dust and a possible contribution from inflationary gravitational waves (as parametrized by the tensor-to-scalar ratio r), using a prior on the frequency spectral behavior of polarized dust emission from previous Planck analysis of other regions of the sky. We find strong evidence for dust and no statistically significant evidence for tensor modes. We probe various model variations and extensions, including adding a synchrotron component in combination with lower frequency data, and find that these make little difference to the r constraint. Finally, we present an alternative analysis which is similar to a map-based cleaning of the dust contribution, and show that this gives similar constraints. The final result is expressed as a likelihood curve for r, and yields an upper limit r_{0.05}<0.12 at 95% confidence. Marginalizing over dust and r, lensing B modes are detected at 7.0σ significance. PMID:25815919

  8. Joint analysis of BICEP2/keck array and Planck Data.

    PubMed

    Ade, P A R; Aghanim, N; Ahmed, Z; Aikin, R W; Alexander, K D; Arnaud, M; Aumont, J; Baccigalupi, C; Banday, A J; Barkats, D; Barreiro, R B; Bartlett, J G; Bartolo, N; Battaner, E; Benabed, K; Benoît, A; Benoit-Lévy, A; Benton, S J; Bernard, J-P; Bersanelli, M; Bielewicz, P; Bischoff, C A; Bock, J J; Bonaldi, A; Bonavera, L; Bond, J R; Borrill, J; Bouchet, F R; Boulanger, F; Brevik, J A; Bucher, M; Buder, I; Bullock, E; Burigana, C; Butler, R C; Buza, V; Calabrese, E; Cardoso, J-F; Catalano, A; Challinor, A; Chary, R-R; Chiang, H C; Christensen, P R; Colombo, L P L; Combet, C; Connors, J; Couchot, F; Coulais, A; Crill, B P; Curto, A; Cuttaia, F; Danese, L; Davies, R D; Davis, R J; de Bernardis, P; de Rosa, A; de Zotti, G; Delabrouille, J; Delouis, J-M; Désert, F-X; Dickinson, C; Diego, J M; Dole, H; Donzelli, S; Doré, O; Douspis, M; Dowell, C D; Duband, L; Ducout, A; Dunkley, J; Dupac, X; Dvorkin, C; Efstathiou, G; Elsner, F; Enßlin, T A; Eriksen, H K; Falgarone, E; Filippini, J P; Finelli, F; Fliescher, S; Forni, O; Frailis, M; Fraisse, A A; Franceschi, E; Frejsel, A; Galeotta, S; Galli, S; Ganga, K; Ghosh, T; Giard, M; Gjerløw, E; Golwala, S R; González-Nuevo, J; Górski, K M; Gratton, S; Gregorio, A; Gruppuso, A; Gudmundsson, J E; Halpern, M; Hansen, F K; Hanson, D; Harrison, D L; Hasselfield, M; Helou, G; Henrot-Versillé, S; Herranz, D; Hildebrandt, S R; Hilton, G C; Hivon, E; Hobson, M; Holmes, W A; Hovest, W; Hristov, V V; Huffenberger, K M; Hui, H; Hurier, G; Irwin, K D; Jaffe, A H; Jaffe, T R; Jewell, J; Jones, W C; Juvela, M; Karakci, A; Karkare, K S; Kaufman, J P; Keating, B G; Kefeli, S; Keihänen, E; Kernasovskiy, S A; Keskitalo, R; Kisner, T S; Kneissl, R; Knoche, J; Knox, L; Kovac, J M; Krachmalnicoff, N; Kunz, M; Kuo, C L; Kurki-Suonio, H; Lagache, G; Lähteenmäki, A; Lamarre, J-M; Lasenby, A; Lattanzi, M; Lawrence, C R; Leitch, E M; Leonardi, R; Levrier, F; Lewis, A; Liguori, M; Lilje, P B; Linden-Vørnle, M; López-Caniego, M; Lubin, P M; Lueker, M; Macías-Pérez, J F; Maffei, B; Maino, D; Mandolesi, N; Mangilli, A; Maris, M; Martin, P G; Martínez-González, E; Masi, S; Mason, P; Matarrese, S; Megerian, K G; Meinhold, P R; Melchiorri, A; Mendes, L; Mennella, A; Migliaccio, M; Mitra, S; Miville-Deschênes, M-A; Moneti, A; Montier, L; Morgante, G; Mortlock, D; Moss, A; Munshi, D; Murphy, J A; Naselsky, P; Nati, F; Natoli, P; Netterfield, C B; Nguyen, H T; Nørgaard-Nielsen, H U; Noviello, F; Novikov, D; Novikov, I; O'Brient, R; Ogburn, R W; Orlando, A; Pagano, L; Pajot, F; Paladini, R; Paoletti, D; Partridge, B; Pasian, F; Patanchon, G; Pearson, T J; Perdereau, O; Perotto, L; Pettorino, V; Piacentini, F; Piat, M; Pietrobon, D; Plaszczynski, S; Pointecouteau, E; Polenta, G; Ponthieu, N; Pratt, G W; Prunet, S; Pryke, C; Puget, J-L; Rachen, J P; Reach, W T; Rebolo, R; Reinecke, M; Remazeilles, M; Renault, C; Renzi, A; Richter, S; Ristorcelli, I; Rocha, G; Rossetti, M; Roudier, G; Rowan-Robinson, M; Rubiño-Martín, J A; Rusholme, B; Sandri, M; Santos, D; Savelainen, M; Savini, G; Schwarz, R; Scott, D; Seiffert, M D; Sheehy, C D; Spencer, L D; Staniszewski, Z K; Stolyarov, V; Sudiwala, R; Sunyaev, R; Sutton, D; Suur-Uski, A-S; Sygnet, J-F; Tauber, J A; Teply, G P; Terenzi, L; Thompson, K L; Toffolatti, L; Tolan, J E; Tomasi, M; Tristram, M; Tucci, M; Turner, A D; Valenziano, L; Valiviita, J; Van Tent, B; Vibert, L; Vielva, P; Vieregg, A G; Villa, F; Wade, L A; Wandelt, B D; Watson, R; Weber, A C; Wehus, I K; White, M; White, S D M; Willmert, J; Wong, C L; Yoon, K W; Yvon, D; Zacchei, A; Zonca, A

    2015-03-13

    We report the results of a joint analysis of data from BICEP2/Keck Array and Planck. BICEP2 and Keck Array have observed the same approximately 400  deg^{2} patch of sky centered on RA 0 h, Dec. -57.5°. The combined maps reach a depth of 57 nK deg in Stokes Q and U in a band centered at 150 GHz. Planck has observed the full sky in polarization at seven frequencies from 30 to 353 GHz, but much less deeply in any given region (1.2  μK deg in Q and U at 143 GHz). We detect 150×3