Science.gov

Sample records for 4x serial rapidio

  1. Implementation of a Multichannel Serial Data Streaming Algorithm using the Xilinx Serial RapidIO Solution

    NASA Technical Reports Server (NTRS)

    Doxley, Charles A.

    2016-01-01

    In the current world of applications that use reconfigurable technology implemented on field programmable gate arrays (FPGAs), there is a need for flexible architectures that can grow as the systems evolve. A project has limited resources and a fixed set of requirements that development efforts are tasked to meet. Designers must develop robust solutions that practically meet the current customer demands and also have the ability to grow for future performance. This paper describes the development of a high speed serial data streaming algorithm that allows for transmission of multiple data channels over a single serial link. The technique has the ability to change to meet new applications developed for future design considerations. This approach uses the Xilinx Serial RapidIO LOGICORE Solution to implement a flexible infrastructure to meet the current project requirements with the ability to adapt future system designs.

  2. Serial Wars

    ERIC Educational Resources Information Center

    Van Orsdel, Lee C.; Born, Kathleen

    2007-01-01

    In a year filled with drama and hyperbole, the serials marketplace churned toward a future whose shape is the subject of fierce debate. Forecasts from commercial publishers touting collapse and disaster seemed oddly out of sync with the profits they enjoyed--around 25 percent on average. Nevertheless, in a market where prices continued to rise and…

  3. Developments in Serials: 1977

    ERIC Educational Resources Information Center

    James, John R.

    1978-01-01

    Discusses issues and developments relating to several aspects of serials, including economics and acquisitions; bibliographic control; automation; education; serials literature and bibliographies; and copyrights. A bibliography is included. (Author/MBR)

  4. Serials in Review: 1972

    ERIC Educational Resources Information Center

    Ashford, Daisy

    1973-01-01

    Major trends in the processing and acquisition of serials during 1972 are reviewed. Principal events were the Williams and Wilkins controversy, the tripling of serials cataloging production at the Library of Congress and progress towards a machine-readable source of serial cataloging information. (23 references) (SM)

  5. Serial Dilution Simulation Lab

    ERIC Educational Resources Information Center

    Keler, Cynthia; Balutis, Tabitha; Bergen, Kim; Laudenslager, Bryanna; Rubino, Deanna

    2010-01-01

    Serial dilution is often a difficult concept for students to understand. In this short dry lab exercise, students perform serial dilutions using seed beads. This exercise helps students gain skill at performing dilutions without using reagents, bacterial cultures, or viral cultures, while being able to visualize the process.

  6. Automated Serials Control System.

    ERIC Educational Resources Information Center

    Pan, Elizabeth

    In 1967, the New York State Library at Albany (NYSL) developed a tape-oriented, off-line serials control system for 10,000 active titles. The system would perform all the serials control functions: bibliographic control, check-in of current receipts, claiming for gaps in receipts and late issues, binding notification for completed sets,…

  7. Weak Topological Insulators and Composite Weyl Semimetals: β -Bi4X4 (X=Br, I)

    NASA Astrophysics Data System (ADS)

    Zhang, Fan; Liu, Cheng-Cheng; Zhou, Jin-Jian; Yao, Yugui

    While strong topological insulators (STI) have been experimentally realized soon after their theoretical predictions, a weak topological insulator (WTI) has yet to be unambiguously confirmed. A major obstacle is the lack of distinct natural cleavage surfaces to test the surface selective hallmark of WTI. With a new scheme, we discover that Bi4X4 (X=Br, I), stable or synthesized before, can be WTI with two natural cleavage surfaces, where two anisotropic Dirac cones stabilize and annihilate, respectively. We further find four surface state Lifshitz transitions under charge doping and two bulk topological phase transitions under uniaxial strain. Near the WTI-STI transition, there emerges a novel Weyl semimetal phase, in which the Fermi arcs generically appear at both cleavage surfaces whereas the Fermi circle only appears at one selected surface.

  8. Weak Topological Insulators and Composite Weyl Semimetals: β -Bi4X4 (X =Br , I)

    NASA Astrophysics Data System (ADS)

    Liu, Cheng-Cheng; Zhou, Jin-Jian; Yao, Yugui; Zhang, Fan

    2016-02-01

    While strong topological insulators (STIs) were experimentally realized soon after they were theoretically predicted, a weak topological insulator (WTI) has yet to be unambiguously confirmed. A major obstacle is the lack of distinct natural cleavage surfaces to test the surface selective hallmark of a WTI. With a new scheme, we discover that β -Bi4X4 (X =Br , I), dynamically stable or synthesized before, can be a prototype WTI with two natural cleavage surfaces, where two anisotropic Dirac cones stabilize and annihilate, respectively. We further find four surface-state Lifshitz transitions under charge doping and two bulk topological phase transitions under uniaxial strain. Near the WTI-STI transition, there emerges a novel Weyl semimetal phase, in which the Fermi arcs generically appear at both cleavage surfaces whereas the Fermi circle only appears at one selected surface.

  9. HIPPI/Serial-HIPPI

    SciTech Connect

    Tolmie, D.E. ); Halvorson, M.G. )

    1991-01-01

    The High-Performance Parallel Interface (HIPPI) is a simple high-performance, point-to-point channel for transmitting digital data at peak data rates of 800 or 1600 Mbit/S. The transmission distance between data processing equipment using copper cabling can be up to 25 meters. This distance may be increased by using a Serial-HIPPI extender. This paper describes the HIPPI channel, the choices considered for a serial extender, and the resulting agreement for the Serial-HIPPI specification. 5 refs., 4 figs.

  10. Classifying serial killers.

    PubMed

    Promish, D I; Lester, D

    1999-11-01

    We attempted to match the appearance and demeanor of 27 serial killers to the postmortem 'signatures' found on their victims' bodies. Our results suggest that a link may exist between postmortem signatures and two complementary appearance-demeanor types.

  11. 23. Photocopy of photograph (4 x 5 inch enlargement of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Photocopy of photograph (4 x 5 inch enlargement of 1940 3-1/4 x 4-1/4 inch print by R. Nevan McCullough; in Cultural Resource files, Supervisor's Office, Mt. Baker-Snoqualmie National Forest) SOUTH FRONT - Suntop Lookout, Forest Road 510, Mt. Baker-Snoqualmie National Forest, Greenwater, Pierce County, WA

  12. Microfluidic serial dilution ladder.

    PubMed

    Ahrar, Siavash; Hwang, Michelle; Duncan, Philip N; Hui, Elliot E

    2014-01-01

    Serial dilution is a fundamental procedure that is common to a large number of laboratory protocols. Automation of serial dilution is thus a valuable component for lab-on-a-chip systems. While a handful of different microfluidic strategies for serial dilution have been reported, approaches based on continuous flow mixing inherently consume larger amounts of sample volume and chip real estate. We employ valve-driven circulatory mixing to address these issues and also introduce a novel device structure to store each stage of the dilution process. The dilution strategy is based on sequentially mixing the rungs of a ladder structure. We demonstrate a 7-stage series of 1 : 1 dilutions with R(2) equal to 0.995 in an active device area of 1 cm(2).

  13. Serial interprocessor communications system

    SciTech Connect

    Labiak, W.; Siemens, P.; Bailey, C.

    1980-04-03

    A serial communications system based on the EIA RS232-C standard with modem control lines has been developed. The DLV11-E interface is used for this purpose. All handshaking is done with the modem control lines. This allows totally independent full duplex communication. The message format consists of eight bit data with odd parity and a sixteen bit checksum on the whole message. All communications are fully interrupt driven. A program was written to load a program into a remote LSI-11 using the serial line without bootstrap ROM.

  14. Serial Services 1992.

    ERIC Educational Resources Information Center

    Shroyer, Andrew; Nanna, Laura

    1992-01-01

    This 1992 price index for serial services presents data on the number of titles, average price, percent of price change, and price indexed to 1977 for the following areas: business; general and humanities; law; science and technology; social sciences; U.S. documents; and H.W. Wilson services. (MES)

  15. Serial interface controller

    SciTech Connect

    Kandasamy, A.

    1995-04-14

    The idea of building a Serial Interface Controller (SIC) proposed by Paul O`Connor, Instrumentation Division, BNL is to determine the feasibility of incorporating a Serial Interface Controlled CMOS IC`s for charge amplification, shaping, analog storage and multiplexing used in particle detectors for high energy physics experiments. The serial data pumped into the CMOS ICs will be used to control many circuit parameters like digitally controlled gain, shaping time, precision preamplifier calibration circuits and many other parameters like timing discriminators mode of operation. The SIC board built will be tested on a Serial Interface Controlled Digital - to - Analog Convertor, which follows either Motorola`s SPI/QSPI or National Semiconductors Microwire interface technique. The DAC chosen for this was MAXIM`s MAX537, a Quad, 12-bit DAC. The function of this controller can be achieved by using some on-shelf micro-controllers like the Motorola`s MC68HC11, which offers dedicated SPI ports. The drawback encountered in using this controller is the overhead involved in putting together an user interface where the user can dynamically change its settings and load the SIC device. This is very critical in testing fewer number of CMOS IC`s having SIC. The SIC board described here takes care of this dynamic user interface issue.

  16. The Serials Marketplace.

    ERIC Educational Resources Information Center

    Treadwell, Jane; Ketcham, Lee

    1991-01-01

    Discusses the results of a national survey of libraries, publishers, and subscription agents that was conducted by the American Library Association (ALA) to address concerns about serials prices. Highlights include library budget trends; resource sharing; selection decisions; library automation; pricing practices of publishers; publisher services;…

  17. Suicide in serial killers.

    PubMed

    Lester, David; White, John

    2010-02-01

    In a sample of 248 killers of two victims in America from 1900 to 2005, obtained from an encyclopedia of serial killers by Newton (2006), those completing suicide did not differ in sex, race, or the motive for the killing from those who were arrested.

  18. Serial Radiohippurate Renal Scintiphotography

    PubMed Central

    Rosenthall, Leonard; Greyson, N. David; Martin, Robert H.

    1970-01-01

    The results of serial radiohippurate scintiphotography in 222 patients are analyzed. The findings in various renal diseases are discussed and compared with those obtained from the excretory urogram, BUN, serum creatinine and creatinine clearance. ImagesFIG. 1FIG. 2FIG. 3FIG. 4aFIG. 4bFIG. 5aFIG. 5b PMID:5536740

  19. Second premolar serial extraction.

    PubMed

    Joondeph, D R; Riedel, R A

    1976-02-01

    Serial extraction of mandibular second premolars should be considered if they are impacted or in cases with moderate arch length deficiency combined with an absence of dentofacial protrusion. The favorable dental changes associated with this approach greatly minimize future orthodontic treatment complexity and time.

  20. Suicide in serial killers.

    PubMed

    Lester, David; White, John

    2010-02-01

    In a sample of 248 killers of two victims in America from 1900 to 2005, obtained from an encyclopedia of serial killers by Newton (2006), those completing suicide did not differ in sex, race, or the motive for the killing from those who were arrested. PMID:20402450

  1. Classifying serial killers.

    PubMed

    Promish, D I; Lester, D

    1999-11-01

    We attempted to match the appearance and demeanor of 27 serial killers to the postmortem 'signatures' found on their victims' bodies. Our results suggest that a link may exist between postmortem signatures and two complementary appearance-demeanor types. PMID:10643649

  2. Stress in Harmonic Serialism

    ERIC Educational Resources Information Center

    Pruitt, Kathryn Ringler

    2012-01-01

    This dissertation proposes a model of word stress in a derivational version of Optimality Theory (OT) called Harmonic Serialism (HS; Prince and Smolensky 1993/2004, McCarthy 2000, 2006, 2010a). In this model, the metrical structure of a word is derived through a series of optimizations in which the "best" metrical foot is chosen…

  3. 16. DETAIL, CLOSEUP OF DECORATIVE PANEL, TOP FLOOR (4 x ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. DETAIL, CLOSE-UP OF DECORATIVE PANEL, TOP FLOOR (4 x 5 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  4. 9. NORTH AND WEST ELEVATIONS (4 x 5 NEGATIVE) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. NORTH AND WEST ELEVATIONS (4 x 5 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  5. 9. (5 X 7 enlargement from 4 X 5 negative) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. (5 X 7 enlargement from 4 X 5 negative) FIRST FLOOR, WINDOW MOLDING ON SOUTH WALL LOOKING SOUTH - Sites Homestead, Monongahela National Forest (Tract 390) East of Route 28, Seneca Rocks, Pendleton County, WV

  6. 13. WATER BEING RELEASED THRU 4 X 4 GATE AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. WATER BEING RELEASED THRU 4 X 4 GATE AT DAM 96 TO PROVIDE WATER CUSHION PRIOR TO OPENING RADIAL GATE - Upper Souris National Wildlife Refuge, Dam 96, Souris River Basin, Foxholm, Surrey (England), ND

  7. Malaysian Serials: Issues and Problems.

    ERIC Educational Resources Information Center

    Bahri, Che Norma

    This paper analyzes the issues and problems while looking at the trends and developments of serials publishing in Malaysia. The first section provides background; topics addressed include the country and people of Malaysia, the history of serials publishing in Malaysia, categories and formats of serials publishing, academic publications,…

  8. Composition during serial learning: a serial position effect.

    PubMed

    Frensch, P A

    1994-03-01

    Composition is a computational learning mechanism that merges serially performed elementary processes into hierarchically organized knowledge structures. The main goals of this research were to explore (a) the role of serial position in composition and (b) the relation between degree of composition and explicit serial recall in serial learning. In 3 experiments, Ss performed a rule-based serial reaction time task in which they had to categorize a sequence of 12 stimuli shown simultaneously on a video monitor. A procedure based on the comparison of reaction times to random sequences and a repeating sequence identified a serial position effect of composition that was, however, moderated by Ss' explicit, postexperimental recall of the repeating sequence. A production-system-based computational model of composition is described that qualitatively reproduces the empirical findings. Implications for the mechanisms governing serial learning are discussed.

  9. Delaware's first serial killer.

    PubMed

    Inguito, G B; Sekula-Perlman, A; Lynch, M J; Callery, R T

    2000-11-01

    The violent murder of Shirley Ellis on November 29, 1987, marked the beginning of the strange and terrible tale of Steven Bryan Pennell's reign as the state of Delaware's first convicted serial killer. Three more bodies followed the first victim, and all had been brutally beaten and sadistically tortured. The body of a fifth woman has never been found. State and county police collaborated with the FBI to identify and hunt down their suspect, forming a task force of over 100 officers and spending about one million dollars. Through their knowledge and experience with other serial killers, the FBI was able to make an amazingly accurate psychological profile of Delaware's serial killer. After months of around-the-clock surveillance, Steven Pennell was arrested on November 29, 1988, one year to the day after the first victim was found. Pennell was found guilty in the deaths of the first two victims on November 29, 1989, and plead no contest to the murder of two others on October 30, 1991. Still maintaining his innocence, he asked for the death penalty so that he could spare his family further agony. Steven Pennell was executed by lethal injection on March 15, 1992.

  10. Delaware's first serial killer.

    PubMed

    Inguito, G B; Sekula-Perlman, A; Lynch, M J; Callery, R T

    2000-11-01

    The violent murder of Shirley Ellis on November 29, 1987, marked the beginning of the strange and terrible tale of Steven Bryan Pennell's reign as the state of Delaware's first convicted serial killer. Three more bodies followed the first victim, and all had been brutally beaten and sadistically tortured. The body of a fifth woman has never been found. State and county police collaborated with the FBI to identify and hunt down their suspect, forming a task force of over 100 officers and spending about one million dollars. Through their knowledge and experience with other serial killers, the FBI was able to make an amazingly accurate psychological profile of Delaware's serial killer. After months of around-the-clock surveillance, Steven Pennell was arrested on November 29, 1988, one year to the day after the first victim was found. Pennell was found guilty in the deaths of the first two victims on November 29, 1989, and plead no contest to the murder of two others on October 30, 1991. Still maintaining his innocence, he asked for the death penalty so that he could spare his family further agony. Steven Pennell was executed by lethal injection on March 15, 1992. PMID:11125664

  11. 4. Photocopy of photograph (4 x 5 inch enlargement of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Photocopy of photograph (4 x 5 inch enlargement of 1942 3-1/2 x 5-7/8 inch print by R. Fromme; in Recreation files, Supervisor's Office, Mt. Baker-Snoqualmie National Forest) EAST (MAIN) ELEVATION OF PROTECTION ASSISTANT'S RESIDENCE - Glacier Ranger Station, Protection Assistant's Residence, Washington State Route 542, Glacier, Whatcom County, WA

  12. 2. 8' x 10' enlargement from 4' x 5' negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. 8' x 10' enlargement from 4' x 5' negative Kevin Kriesel-Coons, Photographer, November 13, 1990 INTERIOR OF HYDRO PLANT, SHOWING CURRENT STATE OF DISREPAIR. - Crosscut Steam Plant, Ancillary Hydro Unit, North side Salt River near Mill Avenue & Washington Street, Tempe, Maricopa County, AZ

  13. 1. 8' x 10' enlargement from 4' x 5' negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. 8' x 10' enlargement from 4' x 5' negative Kevin Kriesel-Coons, Photographer, November 13, 1990 EXTERIOR OF HYDRO PLANT, SHOWING CURRENT STATE OF DISREPAIR. VIEW FROM WALKWAY OVER TAILRACE OF CROSSCUT CANAL TO THE LARGER, ORIGINAL CROSSCUT HYDRO PLANT. - Crosscut Steam Plant, Ancillary Hydro Unit, North side Salt River near Mill Avenue & Washington Street, Tempe, Maricopa County, AZ

  14. Credit WCT. Original 4" x 5" black and white negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 4" x 5" black and white negative is housed in the JPL Archives, Pasadena, California. This view shows the original furnace for burning scrap propellant, the surrounding incinerator pit, and the earth mound personnel shield (JPL negative no. 381-2737, 11 February 1963) - Jet Propulsion Laboratory Edwards Facility, Incinerator, Edwards Air Force Base, Boron, Kern County, CA

  15. 9. 8' X 10' Enlargement from 4' x 5' negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. 8' X 10' Enlargement from 4' x 5' negative Kevin Kriesel-Coons, Photographer PUMPS AFTER REMOVAL FROM PUMPHOUSE BEFORE EXCAVATION OF POND AREA IN 1989. PHOTOGRAPHED LYING ON GROUND NEAR CROSSCUT STEAM PLANT BUILDING. - Crosscut Steam Plant, Indian Bend Pond & Pump Ditch, North side Salt River near Mill Avenue & Washington Street, Tempe, Maricopa County, AZ

  16. 14. Photocopy of photograph (4 x 5 inch reduction of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of photograph (4 x 5 inch reduction of 1939 3-5/8 x 6 inch print by R. Fromme; in Recreation files, Supervisor's Office, Mt. Baker-Snoqualmie National Forest) ENTRANCE TO GLACIER RANGER STATION, FROM WEST. GARAGE AND STORAGE BUILDING IN LEFT BACKGROUND. - Glacier Ranger Station, Washington State Route 542, Glacier, Whatcom County, WA

  17. Serial replica exchange.

    PubMed

    Hagen, Morten; Kim, Byungchan; Liu, Pu; Friesner, Richard A; Berne, B J

    2007-02-15

    Parallel tempering (or the replica exchange method (REM)) is a powerful method for speeding up the sampling of conformational states of systems with rough energy landscapes, like proteins, where stable conformational states can be separated by large energy barriers. The usual implementation of the REM is performed on local computer clusters (or parallel processors) where the different replicas must be run synchronously. Here, we present serial replica exchange (SREM), a method that is equivalent to the standard REM in terms of efficiency yet runs asynchronously on a distributed network of computers. A second advantage is the method's greatly enhanced fault tolerance, which enables the study of biological systems on worldwide distributed computing environments, such as Folding@Home. For proof of concept, we apply the SREM to a single alanine dipeptide molecule in explicit water. We show that the SREM reproduces the thermodynamic and structural properties determined by the REM.

  18. Serial Replica Exchange

    PubMed Central

    Hagen, Morten; Kim, Byungchan; Liu, Pu; Friesner, Richard A.; Berne, B. J.

    2009-01-01

    Parallel tempering (or the replica exchange method (REM)) is a powerful method for speeding up the sampling of conformational states of systems with rough energy landscapes, like proteins, where stable conformational states can be separated by large energy barriers. The usual implementation of the REM is performed on local computer clusters (or parallel processors) where the different replicas must be run synchronously. Here, we present serial replica exchange (SREM), a method that is equivalent to the standard REM in terms of efficiency yet runs asynchronously on a distributed network of computers. A second advantage is the method’s greatly enhanced fault tolerance, which enables the study of biological systems on worldwide distributed computing environments, such as Folding@Home.1 For proof of concept, we apply the SREM to a single alanine dipeptide molecule in explicit water. We show that the SREM reproduces the thermodynamic and structural properties determined by the REM. PMID:17249714

  19. A bit serial sequential circuit

    NASA Technical Reports Server (NTRS)

    Hu, S.; Whitaker, S.

    1990-01-01

    Normally a sequential circuit with n state variables consists of n unique hardware realizations, one for each state variable. All variables are processed in parallel. This paper introduces a new sequential circuit architecture that allows the state variables to be realized in a serial manner using only one next state logic circuit. The action of processing the state variables in a serial manner has never been addressed before. This paper presents a general design procedure for circuit construction and initialization. Utilizing pass transistors to form the combinational next state forming logic in synchronous sequential machines, a bit serial state machine can be realized with a single NMOS pass transistor network connected to shift registers. The bit serial state machine occupies less area than other realizations which perform parallel operations. Moreover, the logical circuit of the bit serial state machine can be modified by simply changing the circuit input matrix to develop an adaptive state machine.

  20. 8. Photographic copy of photograph (from original 4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken May 13, 1942 by unknown photographer. BIRDS-EYE VIEW FROM THE SOUTH OF PRINTING PLANT (STOREHOUSE, BLDG. 85) AT CENTER TOP; STOREHOUSE (BLDG. 88) AT TOP RIGHT; GENERAL PURPOSE ADMINISTRATION BUILDING (BLDG. 90) AT CENTER. - Oakland Army Base, Maritime Street at West Grand Avenue, Oakland, Alameda County, CA

  1. 16. Photographic copy of photograph (from original 4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken prior to June 1942 by unknown photographer. SOUTHWEST BIRDS-EYE VIEW OF WAREHOUSES (BLDGS. 802-805). - Oakland Army Base, Warehouse Type, Tobruk Street, between Warehouse Road & Fifteenth Street, Oakland, Alameda County, CA

  2. 6. Photographic copy of photograph (from original 4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken April 6, 1942 by unknown photographer. SOUTH AND EAST SIDES OBLIQUE VIEW OF PRIVATE VEHICLE INSPECTION BUILDING (VEHICLE SHED, BLDG. 4). - Oakland Army Base, Private Vehicle Inspection Building, Africa Street & Bataan Avenue, Oakland, Alameda County, CA

  3. 11. Photographic copy of photograph (from original 4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken January 31, 1942 by unknown photographer. EAST AND NORTH SIDES OBLIQUE VIEW OF EXCHANGE CAFETERIA (BLDG. 60). - Oakland Army Base, Private Exchange Cafeteria, Bataan Avenue & Attu Street, facing Post Headquarters Building, Oakland, Alameda County, CA

  4. 7. Photographic copy of photograph (from original 4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken January 28, 1942 by unknown photographer. AT CENTER RIGHT, SOUTH AND EAST SIDES OBLIQUE VIEW OF POST HEADQUARTERS BUILDING (ADMINISTRATION BUILDING, BLDG. 1) TAKEN FROM EAST SIDE OF MARITIME STREET. - Oakland Army Base, Maritime Street at West Grand Avenue, Oakland, Alameda County, CA

  5. 7. Photographic copy (reduced to 4 x 5 from 8 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy (reduced to 4 x 5 from 8 X 10 black and white paper reproduction in 1941 appraisal by E.E. Malloy at the Engineering Office, Oakland Army Base, California). Photograph taken between June 1940 and January 1941 by unknown photographer. PARTIAL SOUTH ELEVATION OF VEHICLE MAINTENANCE SHOP (BLDG. 99). - Oakland Army Base, Vehicle Maintenance Shop, Attu Street & Corregidor Avenue, Oakland, Alameda County, CA

  6. Weak Topological Insulators and Composite Weyl Semimetals: β-Bi4X4 (X=Br, I).

    PubMed

    Liu, Cheng-Cheng; Zhou, Jin-Jian; Yao, Yugui; Zhang, Fan

    2016-02-12

    While strong topological insulators (STIs) were experimentally realized soon after they were theoretically predicted, a weak topological insulator (WTI) has yet to be unambiguously confirmed. A major obstacle is the lack of distinct natural cleavage surfaces to test the surface selective hallmark of a WTI. With a new scheme, we discover that β-Bi4X4 (X=Br, I), dynamically stable or synthesized before, can be a prototype WTI with two natural cleavage surfaces, where two anisotropic Dirac cones stabilize and annihilate, respectively. We further find four surface-state Lifshitz transitions under charge doping and two bulk topological phase transitions under uniaxial strain. Near the WTI-STI transition, there emerges a novel Weyl semimetal phase, in which the Fermi arcs generically appear at both cleavage surfaces whereas the Fermi circle only appears at one selected surface. PMID:26919004

  7. Weak Topological Insulators and Composite Weyl Semimetals: β-Bi4X4 (X=Br, I).

    PubMed

    Liu, Cheng-Cheng; Zhou, Jin-Jian; Yao, Yugui; Zhang, Fan

    2016-02-12

    While strong topological insulators (STIs) were experimentally realized soon after they were theoretically predicted, a weak topological insulator (WTI) has yet to be unambiguously confirmed. A major obstacle is the lack of distinct natural cleavage surfaces to test the surface selective hallmark of a WTI. With a new scheme, we discover that β-Bi4X4 (X=Br, I), dynamically stable or synthesized before, can be a prototype WTI with two natural cleavage surfaces, where two anisotropic Dirac cones stabilize and annihilate, respectively. We further find four surface-state Lifshitz transitions under charge doping and two bulk topological phase transitions under uniaxial strain. Near the WTI-STI transition, there emerges a novel Weyl semimetal phase, in which the Fermi arcs generically appear at both cleavage surfaces whereas the Fermi circle only appears at one selected surface.

  8. Serial Network Flow Monitor

    NASA Technical Reports Server (NTRS)

    Robinson, Julie A.; Tate-Brown, Judy M.

    2009-01-01

    Using a commercial software CD and minimal up-mass, SNFM monitors the Payload local area network (LAN) to analyze and troubleshoot LAN data traffic. Validating LAN traffic models may allow for faster and more reliable computer networks to sustain systems and science on future space missions. Research Summary: This experiment studies the function of the computer network onboard the ISS. On-orbit packet statistics are captured and used to validate ground based medium rate data link models and enhance the way that the local area network (LAN) is monitored. This information will allow monitoring and improvement in the data transfer capabilities of on-orbit computer networks. The Serial Network Flow Monitor (SNFM) experiment attempts to characterize the network equivalent of traffic jams on board ISS. The SNFM team is able to specifically target historical problem areas including the SAMS (Space Acceleration Measurement System) communication issues, data transmissions from the ISS to the ground teams, and multiple users on the network at the same time. By looking at how various users interact with each other on the network, conflicts can be identified and work can begin on solutions. SNFM is comprised of a commercial off the shelf software package that monitors packet traffic through the payload Ethernet LANs (local area networks) on board ISS.

  9. Serial Input Output

    SciTech Connect

    Waite, Anthony; /SLAC

    2011-09-07

    Serial Input/Output (SIO) is designed to be a long term storage format of a sophistication somewhere between simple ASCII files and the techniques provided by inter alia Objectivity and Root. The former tend to be low density, information lossy (floating point numbers lose precision) and inflexible. The latter require abstract descriptions of the data with all that that implies in terms of extra complexity. The basic building blocks of SIO are streams, records and blocks. Streams provide the connections between the program and files. The user can define an arbitrary list of streams as required. A given stream must be opened for either reading or writing. SIO does not support read/write streams. If a stream is closed during the execution of a program, it can be reopened in either read or write mode to the same or a different file. Records represent a coherent grouping of data. Records consist of a collection of blocks (see next paragraph). The user can define a variety of records (headers, events, error logs, etc.) and request that any of them be written to any stream. When SIO reads a file, it first decodes the record name and if that record has been defined and unpacking has been requested for it, SIO proceeds to unpack the blocks. Blocks are user provided objects which do the real work of reading/writing the data. The user is responsible for writing the code for these blocks and for identifying these blocks to SIO at run time. To write a collection of blocks, the user must first connect them to a record. The record can then be written to a stream as described above. Note that the same block can be connected to many different records. When SIO reads a record, it scans through the blocks written and calls the corresponding block object (if it has been defined) to decode it. Undefined blocks are skipped. Each of these categories (streams, records and blocks) have some characteristics in common. Every stream, record and block has a name with the condition that each

  10. Bit-serial neuroprocessor architecture

    NASA Technical Reports Server (NTRS)

    Tawel, Raoul (Inventor)

    2001-01-01

    A neuroprocessor architecture employs a combination of bit-serial and serial-parallel techniques for implementing the neurons of the neuroprocessor. The neuroprocessor architecture includes a neural module containing a pool of neurons, a global controller, a sigmoid activation ROM look-up-table, a plurality of neuron state registers, and a synaptic weight RAM. The neuroprocessor reduces the number of neurons required to perform the task by time multiplexing groups of neurons from a fixed pool of neurons to achieve the successive hidden layers of a recurrent network topology.

  11. 4. Credit JPL. Original 4" x 5" black and white ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Credit JPL. Original 4" x 5" black and white negative housed in the JPL Archives, Pasadena, California. This interior view displays the machine shop in the Administration/Shops Building (the compass angle of the view is undetermined). Looking clockwise from the lower left, the machine tools in view are a power hacksaw, a heat-treatment oven (with white gloves on top), a large hydraulic press with a tool grinder at its immediate right; along the wall in the back of the view are various unidentified machine tool attachments and a vertical milling machine. In the background, a machinist is operating a radial drilling machine, to the right of which is a small drill press. To the lower right, another machinist is operating a Pratt & Whitney engine lathe; behind the operator stand a workbench and vertical bandsaw (JPL negative no. 384-10939, 29 July 1975). - Jet Propulsion Laboratory Edwards Facility, Administration & Shops Building, Edwards Air Force Base, Boron, Kern County, CA

  12. Implementing a Serials Barcoding Project.

    ERIC Educational Resources Information Center

    Lennertz, Lora L.; Conway, Cheryl L.

    1997-01-01

    Discusses the process of planning and implementing a barcode project for library serials based on experiences at the University of Arkansas Fayetteville library. Topics include dumb versus smart barcodes, cataloging, classification, application rate of barcode labels, and library staff participation. (Author/LRW)

  13. The Serial Process in Visual Search

    ERIC Educational Resources Information Center

    Gilden, David L.; Thornton, Thomas L.; Marusich, Laura R.

    2010-01-01

    The conditions for serial search are described. A multiple target search methodology (Thornton & Gilden, 2007) is used to home in on the simplest target/distractor contrast that effectively mandates a serial scheduling of attentional resources. It is found that serial search is required when (a) targets and distractors are mirror twins, and (b)…

  14. Serials Control System Procedures and Policies.

    ERIC Educational Resources Information Center

    Schlembach, Mary C.

    This document includes procedures and policies for a networked serials control system originally developed at the Grainger Engineering Library Information Center at the University of Illinois at Urbana-Champaign (UIUC). The serials control systems encompass serials processing, public service, and end-user functions. The system employs a…

  15. 24 CFR 3280.6 - Serial number.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Serial number. 3280.6 Section 3280... DEVELOPMENT MANUFACTURED HOME CONSTRUCTION AND SAFETY STANDARDS General § 3280.6 Serial number. (a) A manufactured home serial number which will identify the manufacturer and the state in which the...

  16. 24 CFR 3280.6 - Serial number.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Serial number. 3280.6 Section 3280... DEVELOPMENT MANUFACTURED HOME CONSTRUCTION AND SAFETY STANDARDS General § 3280.6 Serial number. (a) A manufactured home serial number which will identify the manufacturer and the state in which the...

  17. Serial dependence in visual perception.

    PubMed

    Fischer, Jason; Whitney, David

    2014-05-01

    Visual input often arrives in a noisy and discontinuous stream, owing to head and eye movements, occlusion, lighting changes, and many other factors. Yet the physical world is generally stable; objects and physical characteristics rarely change spontaneously. How then does the human visual system capitalize on continuity in the physical environment over time? We found that visual perception in humans is serially dependent, using both prior and present input to inform perception at the present moment. Using an orientation judgment task, we found that, even when visual input changed randomly over time, perceived orientation was strongly and systematically biased toward recently seen stimuli. Furthermore, the strength of this bias was modulated by attention and tuned to the spatial and temporal proximity of successive stimuli. These results reveal a serial dependence in perception characterized by a spatiotemporally tuned, orientation-selective operator-which we call a continuity field-that may promote visual stability over time.

  18. The fallacy of serial extractions.

    PubMed

    Lee, K Paul

    2013-11-01

    It is suggested that lingually-positioned lower lateral incisors in young children are anatomically correct and not a symptom of crowding. Primary canines with intact periodontal attachments have an important role to play as proprioceptors to encourage growth of the alveolar arch. Extractions of primary cuspids would deprive the alveolus of important growth stimuli. Clinical evidence suggests that serial extraction is counter-productive. The early extraction of primary cuspids will invariably result in crowding of the permanent cuspids. It is a common belief that serial extraction corrects the crowding of lower incisors but the procedure is not evidence based. In reality, the problem is maintained and the 'crowding' shifts to involve the permanent cuspids. Let us not forget the most basic canon of the health profession which is 'first do no harm, and if it is not broken, do not try to fix it'.

  19. The fallacy of serial extractions.

    PubMed

    Lee, K Paul

    2013-11-01

    It is suggested that lingually-positioned lower lateral incisors in young children are anatomically correct and not a symptom of crowding. Primary canines with intact periodontal attachments have an important role to play as proprioceptors to encourage growth of the alveolar arch. Extractions of primary cuspids would deprive the alveolus of important growth stimuli. Clinical evidence suggests that serial extraction is counter-productive. The early extraction of primary cuspids will invariably result in crowding of the permanent cuspids. It is a common belief that serial extraction corrects the crowding of lower incisors but the procedure is not evidence based. In reality, the problem is maintained and the 'crowding' shifts to involve the permanent cuspids. Let us not forget the most basic canon of the health profession which is 'first do no harm, and if it is not broken, do not try to fix it'. PMID:24380143

  20. Nanoflow electrospinning serial femtosecond crystallography

    SciTech Connect

    Sierra, Raymond G.; Laksmono, Hartawan; Kern, Jan; Tran, Rosalie; Hattne, Johan; Alonso-Mori, Roberto; Lassalle-Kaiser, Benedikt; Glöckner, Carina; Hellmich, Julia; Schafer, Donald W.; Echols, Nathaniel; Gildea, Richard J.; Grosse-Kunstleve, Ralf W.; Sellberg, Jonas; McQueen, Trevor A.; Fry, Alan R.; Messerschmidt, Marc M.; Miahnahri, Alan; Seibert, M. Marvin; Hampton, Christina Y.; Starodub, Dmitri; Loh, N. Duane; Sokaras, Dimosthenis; Weng, Tsu-Chien; Zwart, Petrus H.; Glatzel, Pieter; Milathianaki, Despina; White, William E.; Adams, Paul D.; Williams, Garth J.; Boutet, Sébastien; Zouni, Athina; Messinger, Johannes; Sauter, Nicholas K.; Bergmann, Uwe; Yano, Junko; Yachandra, Vittal K.; Bogan, Michael J.

    2012-11-01

    A low flow rate liquid microjet method for delivery of hydrated protein crystals to X-ray lasers is presented. Linac Coherent Light Source data demonstrates serial femtosecond protein crystallography with micrograms, a reduction of sample consumption by orders of magnitude. An electrospun liquid microjet has been developed that delivers protein microcrystal suspensions at flow rates of 0.14–3.1 µl min{sup −1} to perform serial femtosecond crystallography (SFX) studies with X-ray lasers. Thermolysin microcrystals flowed at 0.17 µl min{sup −1} and diffracted to beyond 4 Å resolution, producing 14 000 indexable diffraction patterns, or four per second, from 140 µg of protein. Nanoflow electrospinning extends SFX to biological samples that necessitate minimal sample consumption.

  1. Serial murder by healthcare professionals.

    PubMed

    Yorker, Beatrice Crofts; Kizer, Kenneth W; Lampe, Paula; Forrest, A R W; Lannan, Jacquetta M; Russell, Donna A

    2006-11-01

    The prosecution of Charles Cullen, a nurse who killed at least 40 patients over a 16-year period, highlights the need to better understand the phenomenon of serial murder by healthcare professionals. The authors conducted a LexisNexis search which yielded 90 criminal prosecutions of healthcare providers that met inclusion criteria for serial murder of patients. In addition we reviewed epidemiologic studies, toxicology evidence, and court transcripts, to provide data on healthcare professionals who have been prosecuted between 1970 and 2006. Fifty-four of the 90 have been convicted; 45 for serial murder, four for attempted murder, and five pled guilty to lesser charges. Twenty-four more have been indicted and are either awaiting trial or the outcome has not been published. The other 12 prosecutions had a variety of legal outcomes. Injection was the main method used by healthcare killers followed by suffocation, poisoning, and tampering with equipment. Prosecutions were reported from 20 countries with 40% taking place in the United States. Nursing personnel comprised 86% of the healthcare providers prosecuted; physicians 12%, and 2% were allied health professionals. The number of patient deaths that resulted in a murder conviction is 317 and the number of suspicious patient deaths attributed to the 54 convicted caregivers is 2113. These numbers are disturbing and demand that systemic changes in tracking adverse patient incidents associated with presence of a specific healthcare provider be implemented. Hiring practices must shift away from preventing wrongful discharge or denial of employment lawsuits to protecting patients from employees who kill.

  2. Serial murder by healthcare professionals.

    PubMed

    Yorker, Beatrice Crofts; Kizer, Kenneth W; Lampe, Paula; Forrest, A R W; Lannan, Jacquetta M; Russell, Donna A

    2008-01-01

    The prosecution of Charles Cullen, a nurse who killed at least 40 patients over a 16-year period, highlights the need to better understand the phenomenon of serial murder by healthcare professionals. The authors conducted a LexisNexis search which yielded 90 criminal prosecutions of healthcare providers that met inclusion criteria for serial murder of patients. In addition we reviewed epidemiologic studies, toxicology evidence, and court transcripts, to provide data on healthcare professionals who have been prosecuted between 1970 and 2006. Fifty-four of the 90 have been convicted; 45 for serial murder, four for attempted murder, and five pled guilty to lesser charges. Twenty-four more have been indicted and are either awaiting trial or the outcome has not been published. The other 12 prosecutions had a variety of legal outcomes. Injection was the main method used by healthcare killers followed by suffocation, poisoning, and tampering with equipment. Prosecutions were reported from 20 countries with 40% taking place in the United States. Nursing personnel comprised 86% of the healthcare providers prosecuted; physicians 12%, and 2% were allied health professionals. The number of patient deaths that resulted in a murder conviction is 317 and the number of suspicious patient deaths attributed to the 54 convicted caregivers is 2113. These numbers are disturbing and demand that systemic changes in tracking adverse patient incidents associated with presence of a specific healthcare provider be implemented. Hiring practices must shift away from preventing wrongful discharge or denial of employment lawsuits to protecting patients from employees who kill.

  3. Serial murder by healthcare professionals.

    PubMed

    Yorker, Beatrice Crofts; Kizer, Kenneth W; Lampe, Paula; Forrest, A R W; Lannan, Jacquetta M; Russell, Donna A

    2006-11-01

    The prosecution of Charles Cullen, a nurse who killed at least 40 patients over a 16-year period, highlights the need to better understand the phenomenon of serial murder by healthcare professionals. The authors conducted a LexisNexis search which yielded 90 criminal prosecutions of healthcare providers that met inclusion criteria for serial murder of patients. In addition we reviewed epidemiologic studies, toxicology evidence, and court transcripts, to provide data on healthcare professionals who have been prosecuted between 1970 and 2006. Fifty-four of the 90 have been convicted; 45 for serial murder, four for attempted murder, and five pled guilty to lesser charges. Twenty-four more have been indicted and are either awaiting trial or the outcome has not been published. The other 12 prosecutions had a variety of legal outcomes. Injection was the main method used by healthcare killers followed by suffocation, poisoning, and tampering with equipment. Prosecutions were reported from 20 countries with 40% taking place in the United States. Nursing personnel comprised 86% of the healthcare providers prosecuted; physicians 12%, and 2% were allied health professionals. The number of patient deaths that resulted in a murder conviction is 317 and the number of suspicious patient deaths attributed to the 54 convicted caregivers is 2113. These numbers are disturbing and demand that systemic changes in tracking adverse patient incidents associated with presence of a specific healthcare provider be implemented. Hiring practices must shift away from preventing wrongful discharge or denial of employment lawsuits to protecting patients from employees who kill. PMID:17199622

  4. The sexually sadistic serial killer.

    PubMed

    Warren, J I; Hazelwood, R R; Dietz, P E

    1996-11-01

    This article explores characteristics and crime scene behavior of 20 sexually sadistic serial murderers. The pairing of character pathology with paraphilic arousal to the control and degradation of others is examined as it manifests itself in their murders. Commonalities across murders and across murderers are highlighted, i.e., the execution of murders that are well-planned, the use of preselected locations, captivity, a variety of painful sexual acts, sexual bondage, intentional torture, and death by means of strangulation and stabbing. PMID:8914287

  5. Serial analysis of gene expression.

    PubMed

    Velculescu, V E; Zhang, L; Vogelstein, B; Kinzler, K W

    1995-10-20

    The characteristics of an organism are determined by the genes expressed within it. A method was developed, called serial analysis of gene expression (SAGE), that allows the quantitative and simultaneous analysis of a large number of transcripts. To demonstrate this strategy, short diagnostic sequence tags were isolated from pancreas, concatenated, and cloned. Manual sequencing of 1000 tags revealed a gene expression pattern characteristic of pancreatic function. New pancreatic transcripts corresponding to novel tags were identified. SAGE should provide a broadly applicable means for the quantitative cataloging and comparison of expressed genes in a variety of normal, developmental, and disease states. PMID:7570003

  6. Application specific serial arithmetic arrays

    NASA Technical Reports Server (NTRS)

    Winters, K.; Mathews, D.; Thompson, T.

    1990-01-01

    High performance systolic arrays of serial-parallel multiplier elements may be rapidly constructed for specific applications by applying hardware description language techniques to a library of full-custom CMOS building blocks. Single clock pre-charged circuits have been implemented for these arrays at clock rates in excess of 100 Mhz using economical 2-micron (minimum feature size) CMOS processes, which may be quickly configured for a variety of applications. A number of application-specific arrays are presented, including a 2-D convolver for image processing, an integer polynomial solver, and a finite-field polynomial solver.

  7. Reconciling rising serials costs, the serials budget, and reference needs in a medical library serials retrenchment program: a methodology.

    PubMed

    Spang, L

    1995-01-01

    Devising a coherent serials retrenchment plan while maintaining quality reference service is a dilemma faced by increasing numbers of medical librarians. In 1991, the staff of the Shiffman Medical Library, Wayne State University, began to address increasing serials budget reductions that by 1994 amounted to a projected 20% maximum cut. The resulting retrenchment plan combined an ongoing serials use study, faculty and librarian reviews of cancellation lists, and systematic refinements in interlibrary cooperation and document delivery service. The Shiffman plan provides a constructive framework that can be adapted to other medical libraries facing immediate, major serials retrenchment.

  8. The Relationship Context of Premarital Serial Cohabitation.

    PubMed

    Cohen, Jessica; Manning, Wendy

    2010-09-01

    Even though serial cohabitation is on the rise, it has not been integrated into recent family research. We analyze the National Survey of Family Growth (NSFG) cycle 6 to explore the relationship context of serial cohabitation for women throughout emerging adulthood (N=3,397). We provide a relationship context for serial cohabitation by examining the age at first cohabitation, duration of cohabiting unions, marital expectations and transitions, as well as premarital sexual histories. Furthermore, we examine the change in these relationship indicators across women's birth cohorts. We find that serial cohabitors' co-residential unions are about the same duration as single-instance cohabiting unions. Serial cohabitors start cohabiting younger, report lower marital expectations than single-instance cohabitors and a smaller proportion marry before age 30. Women who have more premarital sex partners have significantly greater odds of serial cohabiting. These findings indicate that women face increasingly complex relationship trajectories during emerging adulthood.

  9. Evolution of human serial pairbonding.

    PubMed

    Fisher, H E

    1989-03-01

    Data on divorce taken for all available years between 1947 and 1981 from the Demographic Yearbooks of the United Nations on 58 peoples illustrate that divorce has a consistent pattern. Divorces exhibit a skewed distribution, characterized by the occurrence of the mode early in marriage (with a divorce peak on or around the fourth year) and a gradual, long-tailed decline following this peak. Divorce risk peaks in age category 25-29 for males and age categories 20-24 and 25-29 for females, the height of reproductive and parenting years, and divorce counts peak among couples with two or fewer children. These properties of divorce are unrelated to divorce rate; they occur in societies with both high and low divorce rates. Data on available horticultural and gathering/hunting societies illustrate that divorce also peaks among young couples early in marriage. Remarriage by divorced and widowed individuals of reproductive age is also common cross-culturally. It is proposed that the above four-year modal marriage duration among couples of reproductive age who divorce reflects a hominid reproductive strategy that probably evolved some time after the appearance of Homo in response to increased female "reproductive burden" and functioned to ensure the survival of the hominid infant through weaning. Serial pairbonding during the female's reproductive years had ancestral adaptive advantages, producing the modern cross-cultural pattern of serial pairbonding. PMID:2929738

  10. The functional genetic link of NLGN4X knockdown and neurodevelopment in neural stem cells

    PubMed Central

    Shi, Lingling; Chang, Xiao; Zhang, Peilin; Coba, Marcelo P.; Lu, Wange; Wang, Kai

    2013-01-01

    Genetic mutations in NLGN4X (neuroligin 4), including point mutations and copy number variants (CNVs), have been associated with susceptibility to autism spectrum disorders (ASDs). However, it is unclear how mutations in NLGN4X result in neurodevelopmental defects. Here, we used neural stem cells (NSCs) as in vitro models to explore the impacts of NLGN4X knockdown on neurodevelopment. Using two shRNAmir-based vectors targeting NLGN4X and one control shRNAmir vector, we modulated NLGN4X expression and differentiated these NSCs into mature neurons. We monitored the neurodevelopmental process at Weeks 0, 0.5, 1, 2, 4 and 6, based on morphological analysis and whole-genome gene expression profiling. At the cellular level, in NSCs with NLGN4X knockdown, we observed increasingly delayed neuronal development and compromised neurite formation, starting from Week 2 through Week 6 post differentiation. At the molecular level, we identified multiple pathways, such as neurogenesis, neuron differentiation and muscle development, which are increasingly disturbed in cells with NLGN4X knockdown. Notably, several postsynaptic genes, including DLG4, NLGN1 and NLGN3, also have decreased expression. Based on in vitro models, NLGN4X knockdown directly impacts neurodevelopmental process during the formation of neurons and their connections. Our functional genomics study highlights the utility of NSCs models in understanding the functional roles of CNVs in affecting neurodevelopment and conferring susceptibility to neurodevelopmental diseases. PMID:23710042

  11. Serial turbo trellis coded modulation using a serially concatenated coder

    NASA Technical Reports Server (NTRS)

    Divsalar, Dariush (Inventor); Dolinar, Samuel J. (Inventor); Pollara, Fabrizio (Inventor)

    2011-01-01

    Serial concatenated trellis coded modulation (SCTCM) includes an outer coder, an interleaver, a recursive inner coder and a mapping element. The outer coder receives data to be coded and produces outer coded data. The interleaver permutes the outer coded data to produce interleaved data. The recursive inner coder codes the interleaved data to produce inner coded data. The mapping element maps the inner coded data to a symbol. The recursive inner coder has a structure which facilitates iterative decoding of the symbols at a decoder system. The recursive inner coder and the mapping element are selected to maximize the effective free Euclidean distance of a trellis coded modulator formed from the recursive inner coder and the mapping element. The decoder system includes a demodulation unit, an inner SISO (soft-input soft-output) decoder, a deinterleaver, an outer SISO decoder, and an interleaver.

  12. Scientific and Technical Serials Holdings Optimization in an Inefficient Market: A LSU Serials Redesign Project Exercise.

    ERIC Educational Resources Information Center

    Bensman, Stephen J.; Wilder, Stanley J.

    1998-01-01

    Analyzes the structure of the library market for scientific and technical (ST) serials. Describes an exercise aimed at a theoretical reconstruction of the ST-serials holdings of Louisiana State University (LSU) Libraries. Discusses the set definitions, measures, and algorithms necessary in the design of a computer program to appraise ST serials.…

  13. Serial Order: A Parallel Distributed Processing Approach.

    ERIC Educational Resources Information Center

    Jordan, Michael I.

    Human behavior shows a variety of serially ordered action sequences. This paper presents a theory of serial order which describes how sequences of actions might be learned and performed. In this theory, parallel interactions across time (coarticulation) and parallel interactions across space (dual-task interference) are viewed as two aspects of a…

  14. The Serial Murderer's Motivations: An Interdisciplinary Review.

    ERIC Educational Resources Information Center

    DeHart, Dana D.; Mahoney, John M.

    1994-01-01

    Defines serial killer as individual who murders two or more victims over an extended period of time, ranging from days to years, with the crimes often being sexually motivated. Reviews existing motivational theories of serial murder and proposes additional explications from range of disciplines. Presents suggestions for future research and…

  15. Modus operandi of female serial killers.

    PubMed

    Wilson, W; Hilton, T

    1998-04-01

    The modus operandi of female serial killers was examined from a chronology of 58 cases in America and 47 cases in 17 other countries, compiled over 25-year intervals. Female serial killers in other countries accounted for a disproportionately greater number of victims, but those in America managed a longer killing career when associated with a low profile modus operandi.

  16. Serials standards work: the next frontier.

    PubMed

    Tseng, S C; Arcand, J L; Brugger, J M; Finn, M; Olson, A J; Somers, S

    1990-04-01

    Serials, one of the more complicated areas of library technical endeavors, has lacked the benefit of standards for a long time. Even now, with standards beginning to be available, the majority of institutions are not working within standard serials formats. A survey to determine the use of serials standards in libraries was conducted in 1988 by the American Library Association, Resources and Technical Services Division, Serials Section, Committee to Study Serials Standards. In the spring of 1988 a survey was sent to a group encompassing the Association of Research Libraries members, CONSER participants, United States Newspaper Program participants, Microform Project libraries, and some vendors and librarians who attended the Committee meetings on a regular basis. The survey questionnaire assessed the current level of serials standards awareness of librarians and vendors. Topics included the type of serials systems used, standards relevant to serials control and union listing and whether or not they are implemented, types and levels of training staff received in the application of standards, benefits of the standards, and areas where standards are most needed. PMID:10104416

  17. [Guided tooth eruption via serial extraction].

    PubMed

    Luyten, C

    1995-01-01

    Crowding of teeth is the result of arch length discrepancy (ALD). Minimal crowding can be solved with slice-technique, more severe crowding (ALD > or = 5 mm) can be intercepted with a serial extraction procedure. In this paper a sequence of serial extraction will be explained and illustrated with case reports.

  18. Modus operandi of female serial killers.

    PubMed

    Wilson, W; Hilton, T

    1998-04-01

    The modus operandi of female serial killers was examined from a chronology of 58 cases in America and 47 cases in 17 other countries, compiled over 25-year intervals. Female serial killers in other countries accounted for a disproportionately greater number of victims, but those in America managed a longer killing career when associated with a low profile modus operandi. PMID:9621726

  19. 47 CFR 95.671 - Serial number.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Serial number. 95.671 Section 95.671 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO... number. The serial number of each CB transmitter must be engraved on the transmitter chassis....

  20. 47 CFR 95.671 - Serial number.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Serial number. 95.671 Section 95.671 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO... number. The serial number of each CB transmitter must be engraved on the transmitter chassis....

  1. Serial Cohabitation and the Marital Life Course

    ERIC Educational Resources Information Center

    Lichter, Daniel T.; Qian, Zhenchao

    2008-01-01

    Using cohort data from the National Longitudinal Survey of Youth, this paper tracks the experiences of "serial cohabitors." Results indicate that only a minority of cohabiting women (about 15%-20%) were involved in multiple cohabitations. Serial cohabitations were overrepresented among economically disadvantaged groups, especially those with low…

  2. Serial Position Functions in General Knowledge

    ERIC Educational Resources Information Center

    Kelley, Matthew R.; Neath, Ian; Surprenant, Aimée M.

    2015-01-01

    Serial position functions with marked primacy and recency effects are ubiquitous in episodic memory tasks. The demonstrations reported here explored whether bow-shaped serial position functions would be observed when people ordered exemplars from various categories along a specified dimension. The categories and dimensions were: actors and age;…

  3. The Unification of Space Qualified Integrated Circuits by Example of International Space Project GAMMA-400

    NASA Astrophysics Data System (ADS)

    Bobkov, S. G.; Serdin, O. V.; Arkhangelskiy, A. I.; Arkhangelskaja, I. V.; Suchkov, S. I.; Topchiev, N. P.

    The problem of electronic component unification at the different levels (circuits, interfaces, hardware and software) used in space industry is considered. The task of computer systems for space purposes developing is discussed by example of scientific data acquisition system for space project GAMMA-400. The basic characteristics of high reliable and fault tolerant chips developed by SRISA RAS for space applicable computational systems are given. To reduce power consumption and enhance data reliability, embedded system interconnect made hierarchical: upper level is Serial RapidIO 1x or 4x with rate transfer 1.25 Gbaud; next level - SpaceWire with rate transfer up to 400 Mbaud and lower level - MIL-STD-1553B and RS232/RS485. The Ethernet 10/100 is technology interface and provided connection with the previously released modules too. Systems interconnection allows creating different redundancy systems. Designers can develop heterogeneous systems that employ the peer-to-peer networking performance of Serial RapidIO using multiprocessor clusters interconnected by SpaceWire.

  4. Cytological and breeding behavior of pentaploids derived from 3x x 4x crosses in potato.

    PubMed

    Carputo, D

    2003-03-01

    Cytology and breeding behavior of Solanum commersonii - S. tuberosum hybrids derived from 3 x x 4 x crosses was examined. The chromosome number of hybrids ranged from hypo-pentaploid (2 n=5 x - 8=52), to hyper-pentaploid (2 n=5 x + 7=67), with the euploid pentaploid 2 n=5 x=60 class predominant. The high variability in chromosome number of the 3 x x 4 x hybrids was attributed to the fact that meiotic restitution during megasporogenesis of the 3 x female may have involved poles with various chromosome numbers, resulting in 2 n eggs with 24-48 chromosomes. Microsporogenesis analyses provided evidence that chromosome pairing between S. commersonii and S. tuberosum genomes occurred. In addition, chromosome distribution at anaphase I and anaphase II revealed an average chromosome number of 29.5 and 29.1 per pole, respectively. To further study the extent of transmission of extra genome chromosomes from pentaploids, 5 x x 4 x and 4 x x 5 x crosses were performed, and the chromosome number of resulting progeny was determined. Ploidy ranged from 2 n=4 x=48 to 2 n=5 x=60 following 5 x x 4 x crosses, and from 2 n=4 x + 1=49 to 2 n=5 x=60 following 4 x x 5 x crosses. These results provided indirect evidence that the pentaploid hybrids produced viable aneuploid gametes with a chromosome number ranging from 24 to 36. They also demonstrated that gametes with large numbers of extra chromosomes can be functional, resulting in sporophytes between the 4 x and 5 x ploidy level. Fertility parameters of crosses involving various (aneuploid) pentaploid genotypes were not influenced by chromosome number, suggesting a buffering effect of polyploidy on aneuploidy. The possibility of successfully using (aneuploid) pentaploid genotypes for further breeding efforts is discussed. PMID:12647063

  5. Serial killers with military experience: applying learning theory to serial murder.

    PubMed

    Castle, Tammy; Hensley, Christopher

    2002-08-01

    Scholars have endeavored to study the motivation and causality behind serial murder by researching biological, psychological, and sociological variables. Some of these studies have provided support for the relationship between these variables and serial murder. However, the study of serial murder continues to be an exploratory rather than explanatory research topic. This article examines the possible link between serial killers and military service. Citing previous research using social learning theory for the study of murder, this article explores how potential serial killers learn to reinforce violence, aggression, and murder in military boot camps. As with other variables considered in serial killer research, military experience alone cannot account for all cases of serial murder. Future research should continue to examine this possible link.

  6. Serial killers with military experience: applying learning theory to serial murder.

    PubMed

    Castle, Tammy; Hensley, Christopher

    2002-08-01

    Scholars have endeavored to study the motivation and causality behind serial murder by researching biological, psychological, and sociological variables. Some of these studies have provided support for the relationship between these variables and serial murder. However, the study of serial murder continues to be an exploratory rather than explanatory research topic. This article examines the possible link between serial killers and military service. Citing previous research using social learning theory for the study of murder, this article explores how potential serial killers learn to reinforce violence, aggression, and murder in military boot camps. As with other variables considered in serial killer research, military experience alone cannot account for all cases of serial murder. Future research should continue to examine this possible link. PMID:12150084

  7. 5. SOUTH AND EAST ELEVATIONS (21/4 x 23/4 NEGATIVE) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. SOUTH AND EAST ELEVATIONS (2-1/4 x 2-3/4 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  8. 10. DETAIL, WEST ENTRANCE (CROPPED PRINT FROM 21/4 x 23/4 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. DETAIL, WEST ENTRANCE (CROPPED PRINT FROM 2-1/4 x 2-3/4 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  9. 20. INTERIOR, COAL CHUTES (G.S.A. PHOTOCOPY, N.D.) (4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. INTERIOR, COAL CHUTES (G.S.A. PHOTOCOPY, N.D.) (4 x 5 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  10. 6. EAST AND NORTH ELEVATIONS (CROPPED PRINT FROM 21/4 x ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. EAST AND NORTH ELEVATIONS (CROPPED PRINT FROM 2-1/4 x 2-3/4 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  11. 17. DETAIL, ROOF STRUCTURE (4 x 5 NEGATIVE) U.S. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. DETAIL, ROOF STRUCTURE (4 x 5 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  12. 11. DETAIL, DECORATIVE PANEL, BREAKERS (CROPPED PRINT FROM 21/4 x ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. DETAIL, DECORATIVE PANEL, BREAKERS (CROPPED PRINT FROM 2-1/4 x 2-3/4 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  13. 14. DETAIL, DECORATIVE PANEL, GENERATOR (CROPPED PRINT FROM 21/4 x ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. DETAIL, DECORATIVE PANEL, GENERATOR (CROPPED PRINT FROM 2-1/4 x 2-3/4 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  14. 19. INTERIOR, 'CHILLER NO. 2' (G.S.A. PHOTOCOPY, N.D.) (4 x ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. INTERIOR, 'CHILLER NO. 2' (G.S.A. PHOTOCOPY, N.D.) (4 x 5 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  15. 13. DETAIL, DECORATIVE PANEL, BLOWER (CROPPED PRINT FROM 21/4 x ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. DETAIL, DECORATIVE PANEL, BLOWER (CROPPED PRINT FROM 2-1/4 x 2-3/4 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  16. 18. INTERIOR, CATWALK AND PIPES (G.S.A. PHOTOCOPY, N.D.) (4 x ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. INTERIOR, CATWALK AND PIPES (G.S.A. PHOTOCOPY, N.D.) (4 x 5 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  17. Electron Momentum Distributions for 4a1 Orbitals of CFxCl4-x in Low Momentum Region: a Possible Evidence of Molecular Geometry Distortion

    NASA Astrophysics Data System (ADS)

    Shan, Xu; Xu, Chun-kai; Yin, Xiao-feng; Zhou, Li-xia; Xu, Ke-zun; Chen, Xiang-jun

    2009-12-01

    Electron momentum distributions for 4a1 orbitals of serial freon molecules CF3Cl, CF2Cl2, and CFCl3 (CFxCl4-x, x = 1-3) have been reanalyzed due to the severe discrepancies between theory and experiment in low momentum region. The tentative calculations using equilibrium geometries of molecular ions have exhibited a great improvement in agreement with the experimental data, which suggests that the molecular geometry distortion may be responsible for the observed high intensities at p < 0.5 a.u. Further analyses show that the severe discrepancies at low momentum region mainly arise from the influence of molecular geometry distortion on C-Cl bonding electron density distributions.

  18. Serial position encoding of signs.

    PubMed

    Miozzo, Michele; Petrova, Anna; Fischer-Baum, Simon; Peressotti, Francesca

    2016-09-01

    Reduced short-term memory (STM) capacity has been reported for sign as compared to speech when items have to be recalled in a specific order. This difference has been attributed to a more precise and efficient serial position encoding in verbal STM (used for speech) than visuo-spatial STM (used for sign). We tested in the present investigation whether the reduced STM capacity with signs stems from a lack of positional encoding available in verbal STM. Error analyses reported in prior studies have revealed that positions are defined in verbal STM by distance from both the start and the end of the sequence (both-edges positional encoding scheme). Our analyses of the errors made by deaf participants with finger-spelled letters revealed that the both-edges positional encoding scheme underlies the STM representation of signs. These results indicate that the cause of the STM disadvantage is not the type of positional encoding but rather the difficulties in binding an item in visuo-spatial STM to its specific position in the sequence. Both-edges positional encoding scheme could be specific of sign, since it has not been found in visuo-spatial STM tasks conducted with hearing participants. PMID:27244095

  19. Background instrumental music and serial recall.

    PubMed

    Nittono, H

    1997-06-01

    Although speech and vocal music are consistently shown to impair serial recall for visually presented items, instrumental music does not always produce a significant disruption. This study investigated the features of instrumental music that would modulate the disruption in serial recall. 24 students were presented sequences of nine digits and required to recall the digits in order of presentation. Instrumental music as played either forward or backward during the task. Forward music caused significantly more disruption than did silence, whereas the reversed music did not. Some higher-order factor may be at work in the effect of background music on serial recall.

  20. Serials Librarianship, 1981-85: A Review Article.

    ERIC Educational Resources Information Center

    Clack, Mary Elizabeth

    1986-01-01

    Reviews nine significant publications in serials librarianship published from 1981 through 1985. Topics covered include publishing and electronic publishing, cataloging, acquisitions, and serials automation. (Author/EM)

  1. Serial order in spatial immediate memory.

    PubMed

    Smyth, M M; Scholey, K A

    1996-02-01

    Serial order effects in spatial memory are investigated in three experiments. In the first an analysis of errors in recall data suggested that immediate transpositions were the most common error and that order errors over 2 or 3 adjacent items accounted for the majority of errors in recall. The first and last serial positions are less error-prone than is the middle position in sets of six and seven items. A second experiment investigated recognition of transpositions and found that immediate transpositions were hardest to recognize but that a traditional serial position effect was not found. This may be due to the difficulty of maintaining one set of spatial items when another set is presented for comparison. A probe experiment, in which subjects were asked to recognize whether a single item came from a memory set and then to assign it to its position in the set indicated that the first and last positions were remembered more accurately than were central positions. The combination of serial order data in recall and position data suggests that there are similarities between serial order and position effects in the verbal and spatial domains and that serial order in spatial sequences is position-based.

  2. Serial position functions in general knowledge.

    PubMed

    Kelley, Matthew R; Neath, Ian; Surprenant, Aimée M

    2015-11-01

    Serial position functions with marked primacy and recency effects are ubiquitous in episodic memory tasks. The demonstrations reported here explored whether bow-shaped serial position functions would be observed when people ordered exemplars from various categories along a specified dimension. The categories and dimensions were: actors and age; animals and weight; basketball players and height; countries and area; and planets and diameter. In all cases, a serial position function was observed: People were more accurate to order the youngest and oldest actors, the lightest and heaviest animals, the shortest and tallest basketball players, the smallest and largest countries, and the smallest and largest planets, relative to intermediate items. The results support an explanation of serial position functions based on relative distinctiveness, which predicts that serial position functions will be observed whenever a set of items can be sensibly ordered along a particular dimension. The serial position function arises because the first and last items enjoy a benefit of having no competitors on 1 side and therefore have enhanced distinctiveness relative to mid-dimension items, which suffer by having many competitors on both sides.

  3. Variations analysis of NLGN3 and NLGN4X gene in Chinese autism patients.

    PubMed

    Xu, Xiaojuan; Xiong, Zhimin; Zhang, Lusi; Liu, Yalan; Lu, Lina; Peng, Yu; Guo, Hui; Zhao, Jingping; Xia, Kun; Hu, Zhengmao

    2014-06-01

    Autism is a neurodevelopmental disorder clinically characterized by impairment of social interaction, deficits in verbal communication, as well as stereotypic and repetitive behaviors. Several studies have implicated that abnormal synaptogenesis was involved in the incidence of autism. Neuroligins are postsynaptic cell adhesion molecules and interacted with neurexins to regulate the fine balance between excitation and inhibition of synapses. Recently, mutation analysis, cellular and mice models hinted neuroligin mutations probably affected synapse maturation and function. In this study, four missense variations [p.G426S (NLGN3), p.G84R (NLGN4X), p.Q162 K (NLGN4X) and p.A283T (NLGN4X)] in four different unrelated patients have been identified by PCR and direct sequencing. These four missense variations were absent in the 453 controls and have not been reported in 1000 Genomes Project. Bioinformatic analysis of the four missense variations revealed that p.G84R and p.A283T were "Probably Damaging". The variations may cause abnormal synaptic homeostasis and therefore trigger the patients more predisposed to autism. By case-control analysis, we identified the common SNPs (rs3747333 and rs3747334) in the NLGN4X gene significantly associated with risk for autism [p = 5.09E-005; OR 4.685 (95% CI 2.073-10.592)]. Our data provided a further evidence for the involvement of NLGN3 and NLGN4X gene in the pathogenesis of autism in Chinese population.

  4. Analyzing Current Serials in Virginia: An Application of the Ulrich's Serials Analysis System

    ERIC Educational Resources Information Center

    Metz, Paul; Gasser, Sharon

    2006-01-01

    VIVA (the Virtual Library of Virginia) was one of the first subscribers to R. R. Bowker's Ulrich's Serials Analysis System (USAS). Creating a database that combined a union report of current serial subscriptions within most academic libraries in the state with the data elements present in Ulrich's made possible a comprehensive analysis designed…

  5. [The serial murder: a few theoretical perspectives].

    PubMed

    Leistedt, S; Linkowski, P

    2011-01-01

    Despite numbers of publications and effort to try to establish the definition, the classification, the epidemiology, the clinical aspects and the psychopathology of serial killers, a universal consensus seems to say the least. Crime, though reduced in some countries, appears to impact more and more consistent worldwide, generating controversial ideas and a multitude of possible explanations. The serial killer usually presents as a caucasian man, aged between 20 and 40 years, often embedded socially and in his family, but with serious psychiatric, personal and especially family history. Usually acting alone, the serial killer plans a crime well in advance, but sometimes within the scope of impulsivity for a minority, the victim not being previously selected. In the latter case, an actual mental illness like psychosis is found. It is clear from numerous psychopathological studies conducted so far that most serial killers are defined as psychopathic sexual sadists, whose childhood was difficult, if not flouted, punctuated by physical and psychological violence situations. In addition, pervasive fantasies combined with thoughts of death, sex and violence are as much in common with the original acts of which they are the instigators. Beyond a relentless media that is constantly watering the public with stories and pictures depicting them as such, serial killers remain an enigma. We can therefore attempt to answer the various questions raised by this phenomenon, the way these people operate and how we can curb the rise, thanks to the neurobiological and neurophysiological approaches that science offers us.

  6. 4. "X15 TYPICAL MISSION." A photo of a map graphic ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. "X-15 TYPICAL MISSION." A photo of a map graphic showing a flight path from Wendover to Edwards, with an inset graphic showing the landing pattern turns. - Edwards Air Force Base, X-15 Engine Test Complex, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

  7. 15. Photographic copy englargement from a 4x5 copy negative (Original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Photographic copy englargement from a 4x5 copy negative (Original drawing located on abandoned NASA site, currently owned by the City of Downey, Downey, California). 1980 BLDG 10, BLDG 42 FLOOR PLAN, NASA MARCH 15 1980. - NASA Industrial Plant, Maintenance Facility, 12214 Lakewood Boulevard, Downey, Los Angeles County, CA

  8. 14. Photographic copy englargement from a 4x5 copy negative (Original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photographic copy englargement from a 4x5 copy negative (Original photograph by original photographer located on abandoned NASA site, currently owned by the City of Downey, Downey, California). AERIAL PHOTOGRAPH 1935-1936 CONSOLIDATED VULTEE AIRCRAFT CORPORATION FROM WEST TO EAST - NASA Industrial Plant, Maintenance Facility, 12214 Lakewood Boulevard, Downey, Los Angeles County, CA

  9. 22. Photographic copy enlargement from a 4x5 copy negative of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Photographic copy enlargement from a 4x5 copy negative of a print. (Original print located on abandoned NASA site, currently owned by the City of Downey, Downey, California). 1954 USAF PLANT 16 AERIAL BUILDING 41 NORTH TO SOUTH. - NASA Industrial Plant, Missile Research Laboratory, 12214 Lakewood Boulevard, Downey, Los Angeles County, CA

  10. 9. Photographic copy enlargement from a 4x5 copy negative. (Original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Photographic copy enlargement from a 4x5 copy negative. (Original drawing located on abandoned NASA site, currently owned by the City of Downey, Downey, California). 1976 BLDGS.25, 41 SITE PLAN. - NASA Industrial Plant, Storage Facility, 12214 Lakewood Boulevard, Downey, Los Angeles County, CA

  11. 5. Photocopy of 173/4' x 27' drawing, ink and colored ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Photocopy of 17-3/4' x 27' drawing, ink and colored wash on paper, catalogued RA337D II S. W. Shulstrup, delineator, 1872 PLAN, SECTIONS, AND ELEVATION OF NORTH CURTAIN WALL ADDITION - Christiansfort, Waterfront, Charlotte Amalie, St. Thomas, VI

  12. 19. (4"X5" image enlarged from 2 1/4" negative) Sam Fowler, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. (4"X5" image enlarged from 2 1/4" negative) Sam Fowler, Photographer, February 1998 VIEW OF GEORGIA DOT BRIDGE NO. 051-00025D-01986N (JAMES P. HOULIHAN BRIDGE). NAVIGATIONAL LIGHT LOCATED ON TOP OF FENDER - Georgia DOT Bridge No. 051-00025D-01986N, US 17 & State Route 25 Spanning Savannah River, Port Wentworth, Chatham County, GA

  13. 6. Photocopy of photograph (original 53/4 x 31/2 inch negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photocopy of photograph (original 5-3/4 x 3-1/2 inch negative located in the Recreation files, Darrington Ranger District). R. L. Fromme, photographer, July 1942. FIRE & TRUCK STORAGE ('L') BLDG. 2275, FOREGROUND - R. & T. WAREHOUSE, DARRINGTON R.S. ('M') BLDG. 2215, BACKGROUND - Darrington Ranger Station, Fire & Truck Storage Building, 1405 Emmens Street, Darrington, Snohomish County, WA

  14. 7. Photocopy of photographca. 1927 (2 1/4 X 2 1/4' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photocopy of photograph--ca. 1927 (2 1/4 X 2 1/4' negative) DETAIL SHOWING ADAPTATION THAT ALLOWED USE OF UPPER END OF ORIGINAL FLUME AND LOWER END JUST RECONSTRUCTED - Power Flume No. 1, Tacoma, La Plata County, CO

  15. Window type: 4x4 multipaned steel window flanked by 1x4 multipaned ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Window type: 4x4 multipaned steel window flanked by 1x4 multipaned steel, casements. Concrete stoop, entry overhang and pipe rail detail also illustrated. Building 36, facing northwest - Harbor Hills Housing Project, 26607 Western Avenue, Lomita, Los Angeles County, CA

  16. 10. July 3, 1947 Photocopy of photograph (41/4 x 27/16 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. July 3, 1947 Photocopy of photograph (4-1/4 x 2-7/16 inch print of July 3, 1947 photograph on file, Coronado N. F. Supervisor's Office, Tucson) COLUMBINE R. S. DWELLING - Columbine Ranger Station, Residence, Milepost 143, State Highway 366, Safford, Graham County, AZ

  17. 6. July, 1947 Photocopy of photograph (11/4 x 27/16 inch ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. July, 1947 Photocopy of photograph (1-1/4 x 2-7/16 inch print, on file, Coronado N. F. Supervisor's Office, Tucson) COLUMBINE R. S. BARN-GARAGE. - Columbine Ranger Station, Garage, Milepost 1343, State Highway 366, Safford, Graham County, AZ

  18. 23. Photographic copy enlargement from a 4x5 copy negative of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Photographic copy enlargement from a 4x5 copy negative of a drawing (Original drawing located on abandoned NASA site, currently owned by the City of Downey, Downey, Calfornia). JANUARY 1960 USAF PLANT 16 MASTER PLOT AND GRID PLAN. - NASA Industrial Plant, Missile Research Laboratory, 12214 Lakewood Boulevard, Downey, Los Angeles County, CA

  19. 15. Photocopy of photograph (original 43/4 x 33/4 inch print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Photocopy of photograph (original 4-3/4 x 3-3/4 inch print located in the Recreation files, Mt. Baker-Snoqualmie N. F.). Photographer unknown, ca. 1941 SKI WARMING HUT, AUSTIN PASS, GLACIER DISTRICT. (NOTE PLANK SPANNING GAP BETWEEN KNOLL AND PORCH) - Austin Pass Warming Hut, Washington Highway 542, Glacier, Whatcom County, WA

  20. 16. Photocopy of drawing enlarged from a 4x5 negative (from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photocopy of drawing enlarged from a 4x5 negative (from Cultural Resources plan files, Gateway National Recreation Area, New Jersey) U.S. Army Corps of Engineers, Designers, 1909 PLAN OF DRAINAGE AND ELECTRICAL SYSTEM OF BATTERY - Fort Hancock, Battery George Arrowsmith, Southwest edge of Sandy Point extending to Horseshoe Cove, Fort Hancock, Monmouth County, NJ

  1. Stochastic modeling of a serial killer.

    PubMed

    Simkin, M V; Roychowdhury, V P

    2014-08-21

    We analyze the time pattern of the activity of a serial killer, who during 12 years had murdered 53 people. The plot of the cumulative number of murders as a function of time is of "Devil's staircase" type. The distribution of the intervals between murders (step length) follows a power law with the exponent of 1.4. We propose a model according to which the serial killer commits murders when neuronal excitation in his brain exceeds certain threshold. We model this neural activity as a branching process, which in turn is approximated by a random walk. As the distribution of the random walk return times is a power law with the exponent 1.5, the distribution of the inter-murder intervals is thus explained. We illustrate analytical results by numerical simulation. Time pattern activity data from two other serial killers further substantiate our analysis.

  2. Stochastic modeling of a serial killer

    PubMed Central

    Simkin, M.V.; Roychowdhury, V.P.

    2014-01-01

    We analyze the time pattern of the activity of a serial killer, who during twelve years had murdered 53 people. The plot of the cumulative number of murders as a function of time is of “Devil’s staircase” type. The distribution of the intervals between murders (step length) follows a power law with the exponent of 1.4. We propose a model according to which the serial killer commits murders when neuronal excitation in his brain exceeds certain threshold. We model this neural activity as a branching process, which in turn is approximated by a random walk. As the distribution of the random walk return times is a power law with the exponent 1.5, the distribution of the inter-murder intervals is thus explained. We illustrate analytical results by numerical simulation. Time pattern activity data from two other serial killers further substantiate our analysis. PMID:24721476

  3. Serial position effects in mild cognitive impairment.

    PubMed

    Howieson, Diane B; Mattek, Nora; Seeyle, Adriana M; Dodge, Hiroko H; Wasserman, Dara; Zitzelberger, Tracy; Jeffrey, Kaye

    2011-03-01

    Mild cognitive impairment (MCI) is often associated with the preclinical phase of Alzheimer's disease (AD). Special scoring of word-list recall data for serial position has been suggested to improve discrimination of normal aging from dementia. We examined serial position effects in word-list recall for MCI participants compared to Alzheimer patients and controls. Individuals with MCI, like Alzheimer patients, had a diminished primacy effect in recalling words from a list. No alternative scoring system was better than standard scoring of word-list recall in distinguishing MCI patients from controls. Retention weighted scoring improved the discrimination of MCI and AD groups.

  4. Serial multiplier arrays for parallel computation

    NASA Technical Reports Server (NTRS)

    Winters, Kel

    1990-01-01

    Arrays of systolic serial-parallel multiplier elements are proposed as an alternative to conventional SIMD mesh serial adder arrays for applications that are multiplication intensive and require few stored operands. The design and operation of a number of multiplier and array configurations featuring locality of connection, modularity, and regularity of structure are discussed. A design methodology combining top-down and bottom-up techniques is described to facilitate development of custom high-performance CMOS multiplier element arrays as well as rapid synthesis of simulation models and semicustom prototype CMOS components. Finally, a differential version of NORA dynamic circuits requiring a single-phase uncomplemented clock signal introduced for this application.

  5. The eyeball killer: serial killings with postmortem globe enucleation.

    PubMed

    Coyle, Julie; Ross, Karen F; Barnard, Jeffrey J; Peacock, Elizabeth; Linch, Charles A; Prahlow, Joseph A

    2015-05-01

    Although serial killings are relatively rare, they can be the cause of a great deal of anxiety while the killer remains at-large. Despite the fact that the motivations for serial killings are typically quite complex, the psychological analysis of a serial killer can provide valuable insight into how and why certain individuals become serial killers. Such knowledge may be instrumental in preventing future serial killings or in solving ongoing cases. In certain serial killings, the various incidents have a variety of similar features. Identification of similarities between separate homicidal incidents is necessary to recognize that a serial killer may be actively killing. In this report, the authors present a group of serial killings involving three prostitutes who were shot to death over a 3-month period. Scene and autopsy findings, including the unusual finding of postmortem enucleation of the eyes, led investigators to recognize the serial nature of the homicides.

  6. The eyeball killer: serial killings with postmortem globe enucleation.

    PubMed

    Coyle, Julie; Ross, Karen F; Barnard, Jeffrey J; Peacock, Elizabeth; Linch, Charles A; Prahlow, Joseph A

    2015-05-01

    Although serial killings are relatively rare, they can be the cause of a great deal of anxiety while the killer remains at-large. Despite the fact that the motivations for serial killings are typically quite complex, the psychological analysis of a serial killer can provide valuable insight into how and why certain individuals become serial killers. Such knowledge may be instrumental in preventing future serial killings or in solving ongoing cases. In certain serial killings, the various incidents have a variety of similar features. Identification of similarities between separate homicidal incidents is necessary to recognize that a serial killer may be actively killing. In this report, the authors present a group of serial killings involving three prostitutes who were shot to death over a 3-month period. Scene and autopsy findings, including the unusual finding of postmortem enucleation of the eyes, led investigators to recognize the serial nature of the homicides. PMID:25682709

  7. Advantages and disadvantages of phonological similarity in serial recall and serial recognition of nonwords.

    PubMed

    Lian, Arild; Karlsen, Paul Johan

    2004-03-01

    The phonological similarity effect (PSE) was studied with lists of nonwords in one task of serial recall and one task of serial recognition. PSE was critically affected by the scoring procedure and the type of phonological similarity involved, and the effect diverged in several ways from the findings of previous studies on words. PSE was absent in serial recall, regardless of scoring procedure, when phonologically similar items that shared the midvowel were compared with phonologically distinct items. PSE was reversed when serial recall and item recall scores of rhyme items and consonant frame items were compared with distinct items, but it was present in the position accuracy score of rhyme lists. In serial recognition, PSE was absent when rhyme lists were compared with distinct lists. Recognition was better for consonant frame lists than for rhyme lists, and there was a marginally significant reversal of PSE when consonant frame lists were compared with distinct lists. In the view of Fallon, Groves, and Tehan's (1999) study and the present study, rhyming improves item recall and serial recall but diminishes position accuracy, regardless of lexicality. But consonant frame lists with differing midvowels have higher item recall, serial recall, and position accuracy scores than do rhyme lists.

  8. A Serials Holdings List Using UNIX Refer.

    ERIC Educational Resources Information Center

    Boyce, Judith I.; Boyce, Bert R.

    1987-01-01

    Describes the production of an automated union list of serials holdings at minimal cost by a small consortium of state government libraries in Louisiana. Use of the UNIX Refer system without any modifications for data entry and production is described. (EM)

  9. Cooperative Serials Review: A Feasibility Study.

    ERIC Educational Resources Information Center

    Boston Library Consortium, MA.

    This report describes a 1980/81 project concerned with the formulation and validation of a model for determining whether cancellation and/or consolidation of serial subscriptions and holdings should be recommended to maximize the cost-effective use of combined collections and staff resources in the Boston Library Consortium (BLC). The publication…

  10. Inverting the modality effect in serial recall.

    PubMed

    Beaman, C Philip

    2002-04-01

    Differences in recall ability between immediate serial recall of auditorily and visually presented verbal material have traditionally been considered restricted to the end of to-be-recalled lists, the recency section of the serial position curve (e.g., Crowder & Morton, 1969). Later studies showed that--under certain circumstances--differences in recall between the two modalities can be observed across the whole of the list (Frankish, 1985). However in all these studies the advantage observed is for recall of material presented in the auditorily modality. Six separate conditions across four experiments demonstrate that a visual advantage can be obtained with serial recall if participants are required to recall the list in two distinct sections using serial recall. Judged on a list-wide basis, the visual advantage is of equivalent size to the auditory advantage of the classical modality effect. The results demonstrate that differences in representation of auditory and visual verbal material in short-term memory persist beyond lexical and phonological categorization and are problematic for current theories of the modality effect.

  11. Serial Position Curves in Free Recall

    ERIC Educational Resources Information Center

    Laming, Donald

    2010-01-01

    The scenario for free recall set out in Laming (2009) is developed to provide models for the serial position curves from 5 selected sets of data, for final free recall, and for multitrial free recall. The 5 sets of data reflect the effects of rate of presentation, length of list, delay of recall, and suppression of rehearsal. Each model…

  12. Supporting the Serial in the SERIOL Model

    ERIC Educational Resources Information Center

    Whitney, Carol

    2008-01-01

    It is commonly assumed that orthographical lexical access in visual word recognition takes place in parallel, with all letters activated at the same time. In contrast, in the SERIOL model of letter-position encoding, letters fire sequentially (Whitney, 2001). I present further support for such seriality on several fronts. (1) The reasons that led…

  13. Statistical inference for serial dilution assay data.

    PubMed

    Lee, M L; Whitmore, G A

    1999-12-01

    Serial dilution assays are widely employed for estimating substance concentrations and minimum inhibitory concentrations. The Poisson-Bernoulli model for such assays is appropriate for count data but not for continuous measurements that are encountered in applications involving substance concentrations. This paper presents practical inference methods based on a log-normal model and illustrates these methods using a case application involving bacterial toxins.

  14. Advances in Serials Management. Volume 6.

    ERIC Educational Resources Information Center

    Hepfer, Cindy, Ed.; Gammon, Julia, Ed.; Malinowski, Teresa, Ed.

    In order to further discussion and support constructive change, this volume presents the following eight papers on various dimensions of serials management: (1) "CD-ROMs, Surveys, and Sales: The OSA [Optical Society of America] Experience" (Frank E. Harris and Alan Tourtlotte); (2) "Management and Integration of Electronic Journals into the…

  15. Serial Position Effects in Nonword Repetition

    ERIC Educational Resources Information Center

    Gupta, P.; Lipinski, J.; Abbs, B.; Lin, P.H.

    2005-01-01

    A growing body of research has emphasized the linkage between performance in immediate serial recall of lists, nonword repetition, and word learning. Recently, it has been reported that primacy and recency effects are obtained in repetition of individual syllables within nonwords (Gupta, in press). Five experiments examined whether such…

  16. 24 CFR 3280.6 - Serial number.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Serial number. 3280.6 Section 3280.6 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND......

  17. Notes for Serials Cataloging. Second Edition.

    ERIC Educational Resources Information Center

    Geer, Beverley, Ed.; Caraway, Beatrice L., Ed.

    Notes are indispensable to serials cataloging. Researchers, reference librarians, and catalogers regularly use notes on catalog records and, as the audience for these notes has expanded from the local library community to the global Internet community, the need for notes to be cogent, clear, and useful is greater than ever. This book is a…

  18. Proposal for a National Serials Data System.

    ERIC Educational Resources Information Center

    Adams, Scott

    A hypothetical model is given for a National Serials Data System based on the best educated guesses of what the system should do and how, therefore, it should function. The model focuses attention on the ultimate goal rather than on the decision-making processes relating to choice of data elements, unique identification codes, etc. This conceptual…

  19. Parallel and Serial Processes in Visual Search

    ERIC Educational Resources Information Center

    Thornton, Thomas L.; Gilden, David L.

    2007-01-01

    A long-standing issue in the study of how people acquire visual information centers around the scheduling and deployment of attentional resources: Is the process serial, or is it parallel? A substantial empirical effort has been dedicated to resolving this issue. However, the results remain largely inconclusive because the methodologies that have…

  20. Recalling visual serial order for verbal sequences.

    PubMed

    Logie, Robert H; Saito, Satoru; Morita, Aiko; Varma, Samarth; Norris, Dennis

    2016-05-01

    We report three experiments in which participants performed written serial recall of visually presented verbal sequences with items varying in visual similarity. In Experiments 1 and 2 native speakers of Japanese recalled visually presented Japanese Kanji characters. In Experiment 3, native speakers of English recalled visually presented words. In all experiments, items varied in visual similarity and were controlled for phonological similarity. For Kanji and for English, performance on lists comprising visually similar items was overall poorer than for lists of visually distinct items across all serial positions. For mixed lists in which visually similar and visually distinct items alternated through the list, a clear "zig-zag" pattern appeared with better recall of the visually distinct items than for visually similar items. This is the first time that this zig-zag pattern has been shown for manipulations of visual similarity in serial-ordered recall. These data provide new evidence that retaining a sequence of visual codes relies on similar principles to those that govern the retention of a sequence of phonological codes. We further illustrate this by demonstrating that the data patterns can be readily simulated by at least one computational model of serial-ordered recall, the Primacy model (Page and Norris, Psychological Review, 105(4), 761-81, 1998). Together with previous evidence from neuropsychological studies and experimental studies with healthy adults, these results are interpreted as consistent with two domain-specific, limited-capacity, temporary memory systems for phonological material and for visual material, respectively, each of which uses similar processes that have evolved to be optimal for retention of serial order.

  1. 32. PORT PROFILE OF THE ALABAMA. Uncopyrighted 31/4'x5'photograph taken by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. PORT PROFILE OF THE ALABAMA. Uncopyrighted 3-1/4'x5'photograph taken by Thigpen Photography, c. 1965. Written on back of photo: 'This is what the vessel looked like when I bought her in 1966 R.S. Douglas.' Also, stamped on back is: Thigpen Photography 1442 So. Beltline Highway Mobile, Alabama 46609 to reorder specify no. M7062-1 - Pilot Schooner "Alabama", Moored in harbor at Vineyard Haven, Vineyard Haven, Dukes County, MA

  2. 3. Credit WCT. Original 4"x5" black and white negative is ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Credit WCT. Original 4"x5" black and white negative is housed in the JPL Archives, Pasadena, California. This view of the vibrator shows a large mounted ATS (Advanced Technology Satellite) motor. Accelerometer instrumentation has been added. JPL caption reads "C-210E Vibration Exciter ATS Accelerometer Installation on Q4TX AXIS" (JPL negative no. 384-5848B, 31 March 1966). - Jet Propulsion Laboratory Edwards Facility, Test Stand G, Edwards Air Force Base, Boron, Kern County, CA

  3. Credit WCT. Original 21/4"x21/4" color negative is housed in the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 2-1/4"x2-1/4" color negative is housed in the JPL Photography Laboratory, Pasadena, California. At one time, Building 4285/E-86 accommodated tensile testing of propellant samples. This view shows a tensile strength tester set up for propellant tests, under the supervision of JPL staff member Milton Clay (JPL negative no. JPL-10291AC, 27 January 1989) - Jet Propulsion Laboratory Edwards Facility, Casting & Curing Building, Edwards Air Force Base, Boron, Kern County, CA

  4. 18. (4"X5" image enlarged from 2 1/4" negative) Sam Fowler, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. (4"X5" image enlarged from 2 1/4" negative) Sam Fowler, Photographer, February 1998 VIEW OF GEORGIA DOT BRIDGE NO. 051-00025D-01986N (JAMES P. HOULIHAN BRIDGE) APPROACH SPAN FENDER. DOLPHIN LOCATED AT RIGHT. NAVIGATIONAL LIGHT LOCATED ON TOP OF FENDER - Georgia DOT Bridge No. 051-00025D-01986N, US 17 & State Route 25 Spanning Savannah River, Port Wentworth, Chatham County, GA

  5. 14. Photocopy of photograph (original 43/4 x 33/4 inch print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of photograph (original 4-3/4 x 3-3/4 inch print located in the Recreation files, Mt. Baker-Snoqualmie N. F.). Photographer unknown, ca. 1941 AUSTIN PASS SKI HUT (WITH BAGLEY LAKE BELOW) AT HEATHER MEADOWS RECREATION AREA. WIDE-CONED MOUNTAIN IN CENTER BACKGROUND IS MOUNT LARRABEE; CANADIAN RED MOUNTAIN IS PEAK TO LEFT. GLACIER DISTRICT. - Austin Pass Warming Hut, Washington Highway 542, Glacier, Whatcom County, WA

  6. Credit WCT. Original 4"x5" black and white negative is housed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 4"x5" black and white negative is housed in the JPL Archives, Pasadena, California. This view shows the underfloor ductwork of Building E-46 during construction. The ductwork conducts hot or cold air to maintain required temperatures in the curing chamber (JPL negative no. 381-2569, 12 December 1962) - Jet Propulsion Laboratory Edwards Facility, Solid Propellant Conditioning Building, Edwards Air Force Base, Boron, Kern County, CA

  7. Recreation of the 28-entity IGES test file using the ComputerVision CADDS 4X

    NASA Technical Reports Server (NTRS)

    Kuan, Anchyi; Shah, Saurin; Smith, Kevin

    1987-01-01

    An Initial Graphics Exchange Specification (IGES) test file is called the 28 Entity IGES Test File. This file contains 28 geometric and annotation entities which are considered the basic entities that an IGES translator for any CAD system should support. The main purpose was to determine how the IGES preprocessor supports the 28 entities through recreation of the 28 Entity IGES Test File on the ComputerVision CADDS 4X. Test procedure is described and test results are presented.

  8. Credit WCT. Original 21/4"x21/4" color negative is housed in the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 2-1/4"x2-1/4" color negative is housed in the JPL Photography Laboratory, Pasadena, California. This interior view of the Xray chamber shows operator Leonard "Dutch" Sebring positioning the 1 million electron volt X-ray machine to make an image of a Syncom 2 motor (JPL negative no. JPL-10285BC, 27 January 1989) - Jet Propulsion Laboratory Edwards Facility, Radiographic Inspection Building, Edwards Air Force Base, Boron, Kern County, CA

  9. Credit WCT. Original 21/4"x21/4" color negative is housed in the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 2-1/4"x2-1/4" color negative is housed in the JPL Photography Laboratory, Pasadena, California. JPL staff member Leonard "Dutch" Sebring loads propellant grain into tube for a BATES (Ballistic And Test Evaluation System) test (JPL negative no. JPL-10279BC, 27 January 1989) - Jet Propulsion Laboratory Edwards Facility, Weigh & Test Preparation Building, Edwards Air Force Base, Boron, Kern County, CA

  10. Credit WCT. Original 4"x5" black and white negative is housed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 4"x5" black and white negative is housed in the JPL Archives, Pasadena, California. This view shows Building E-39 under construction. E-39 is an example of the typical reinforced concrete block construction of the E-30s and E-40s structures (JPL negative no. 381-2586, 13 December 1962) - Jet Propulsion Laboratory Edwards Facility, Propellant Curing Building, Edwards Air Force Base, Boron, Kern County, CA

  11. Laparoscopic Habib™ 4X: a bipolar radiofrequency device for bloodless laparoscopic liver resection

    PubMed Central

    Pai, M.; Navarra, G.; Ayav, A.; Sommerville, C.; Khorsandi, S. K.; Damrah, O.; Jiao, L. R.

    2008-01-01

    Background. In recent years the progress of laparoscopic procedures and the development of new and dedicated technologies have made laproscopic hepatic surgery feasible and safe. In spite of this laparoscopic liver resection remains a surgical procedure of great challenge because of the risk of massive bleeding during liver transection and the complicated biliary and vascular anatomy in the liver. A new laparoscopic device is reported here to assist liver resection laparoscopically. Methods. The laparoscopic Habib™ 4X is a bipolar radiofrequency device consisting of a 2x2 array of needles arranged in a rectangle. It is introduced perpendicularly into the liver, along the intended transection line. It produces coagulative necrosis of the liver parenchyma sealing biliary radicals and blood vessels and enables bloodless transection of the liver parenchyma. Results. Twenty-four Laparoscopic liver resections were performed with LH4X out of a total of 28 attempted resections over 12 months. Pringle manoeuvre was not used in any of the patients. None of the patients required intraoperative transfusion of red cells or blood products. Conclusion. Laparoscopic liver resection can be safely performed with laparoscopic Habib™ 4X with a significantly low risk of intraoperative bleeding or postoperative complications. PMID:18773100

  12. Thermoelectric transport properties of Ca3Co4- x Ni x O9+ δ oxide materials

    NASA Astrophysics Data System (ADS)

    Park, K.; Cha, J. S.; Nam, S. W.; Choi, S.-M.; Seo, W.-S.; Lee, S.; Lim, Y. S.

    2016-01-01

    Nano-sized Ca3Co4- x Ni x O9+ δ (0 ≤ x ≤ 0.3) thermoelectric powders are synthesized by using the solution combustion method, with aspartic acid as a combustion fuel. The synthesized Ca3Co4- x Ni x O9+ δ nano-sized powders exhibit a spherical-like shape and a smooth surface. Higher Ni content results in a smaller grain size and a higher porosity, resulting in a decrease in the electrical conductivity. However, the Seebeck coefficient of Ni-added Ca3Co4O9 is much higher than that of Ca3Co4O9. The highest power factor (1.4 × 10-4 Wm-1K-2), which is more than nine times larger than that of Ca3Co4O9, is attained for Ca3Co0.38Ni0.2O9+ δ at 800 °C. The addition of a small amount of Ni is highly effective in improving the thermoelectric properties of Ca3Co4O9. We believe that Ca3Co4- x Ni x O9+ δ is a potential p-type thermoelectric material for renewable energy conversion.

  13. Cementable implant-supported prosthesis, serial extraction, and serial implant installation: case report.

    PubMed

    Rosen, Harry; Gornitsky, Mervyn

    2004-12-01

    Cement-retained implant-supported prostheses are particularly indicated where access for screw placement is limited or impossible like in posterior locations or where there is limited jaw opening. The patient in this case report suffered from limited jaw opening as a result of a long history of temporomandibular joint ankylosis related to hemophilia. Cement-retained implant-supported prostheses coupled with serial extraction, serial implant installations, and chairside provisional restorations made uneventful treatment possible.

  14. Serial Recall and the Modality Effect: Effects of Word Frequency

    ERIC Educational Resources Information Center

    Watkins, Olga C.; Watkins, Michael J.

    1977-01-01

    Serial position curves for the immediate serial recall of supraspan word lists were investigated as a joint function of input modality and the frequency with which the list words occur in everyday usage. (Editor)

  15. Magnetic Particle Recovery of Serial Numbers

    SciTech Connect

    D. Utrata; M.J. Johnson

    2003-10-01

    One method used by crime labs to recover obliterated serial numbers in steel firearms (ferrous samples) is the magnetic particle technique. The use of this method is predicated on the detection of metal deformation present under stamped serial numbers after the visible stamp has been removed. Equipment specialized for this detection is not used in these attempts; a portable magnetic yoke used typically for flaw detection on large weldments or structures, along with dry visible magnetic powders, have been the tools of criminologists working in this area. Crime labs have reported low success rates using these tools [1, 2]. This is not surprising when one considers that little formal development has apparently evolved for use in such investigations since the publication of seminal work in this area some time ago [3]. The aim of this project is to investigate specific aspects of magnetic particle inspection for serial number recovery. This includes attempts to understand the magnetic characteristics of different steels that affect their performance in the test, such as varying results for carbon steels and alloy steels after different thermal and forming treatments. Also investigated are the effects of the nature of the sample magnetization (AC, rectified DC, and true DC) and the use of various detection media, such as visible powders and fluorescent sprays, on test outcome. Additionally, some aspects of surface preparation of firearm samples prior to number recovery were included in this work. The scope of this report includes a brief overview of the magnetic particle inspection method in general and its applications to forensic serial number recovery. This is followed by a description of how such investigations were simulated on lab samples, including a look at how the microstructure of a given steel will affect its performance in the test. Investigations into the serial number recovery in a series of ferromagnetic firearms (both steel and certain stainless steels

  16. National Serials Data Program; Phase I, Final Report.

    ERIC Educational Resources Information Center

    Library of Congress, Washington, DC. Information Systems Office.

    The primary objective of the National Serials Data Program is the design and implementation of a national serials information system. The goals of this system are the provisions of timely, accurate, and comprehensive information about serial publications within a framework of quantitative efficiency and agreed upon cost effectiveness. The intent…

  17. English Literature: A Student's Guide to Serial Bibliographies.

    ERIC Educational Resources Information Center

    McGill Univ., Montreal (Quebec). McLennan Library.

    This selected guide to serial bibliographies covering English language literature is based on an essay bibliography by David E. Pownall. Other bibliographies of serial bibliographies which were consulted include "A Reference Guide to English Studies,""Periodicals Containing Reviews and Bibliographies,""Serial Bibliographies in the Humanities and…

  18. 7 CFR 29.9205 - Identification number (farm serial number).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Identification number (farm serial number). 29.9205 Section 29.9205 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... number (farm serial number). The serial number assigned to an individual farm by the appropriate...

  19. 7 CFR 29.9205 - Identification number (farm serial number).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Identification number (farm serial number). 29.9205 Section 29.9205 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... number (farm serial number). The serial number assigned to an individual farm by the appropriate...

  20. Output order in immediate serial recall.

    PubMed

    Tan, Lydia; Ward, Geoff

    2007-07-01

    In two experiments, we examined the effect of output order in immediate serial recall (ISR). In Experiment 1, three groups of participants saw lists of eight words and wrote down the words in the rows corresponding to their serial positions in an eight-row response grid. One group was precued to respond in forward order, a second group was precued to respond in any order, and a third group was postcued for response order. There were significant effects of output order, but not of cue type. Relative to the forward output order, the free output order led to enhanced recency and diminished primacy, with superior performance for words output early in recall. These results were replicated in Experiment 2 using six-item lists, which further suggests that output order plays an important role in the primacy effect in ISR and that the recency items are most highly accessible at recall.

  1. Serial Millisecond Crystallography of Membrane Proteins.

    PubMed

    Jaeger, Kathrin; Dworkowski, Florian; Nogly, Przemyslaw; Milne, Christopher; Wang, Meitian; Standfuss, Joerg

    2016-01-01

    Serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs) is a powerful method to determine high-resolution structures of pharmaceutically relevant membrane proteins. Recently, the technology has been adapted to carry out serial millisecond crystallography (SMX) at synchrotron sources, where beamtime is more abundant. In an injector-based approach, crystals grown in lipidic cubic phase (LCP) or embedded in viscous medium are delivered directly into the unattenuated beam of a microfocus beamline. Pilot experiments show the application of microjet-based SMX for solving the structure of a membrane protein and compatibility of the method with de novo phasing. Planned synchrotron upgrades, faster detectors and software developments will go hand-in-hand with developments at free-electron lasers to provide a powerful methodology for solving structures from microcrystals at room temperature, ligand screening or crystal optimization for time-resolved studies with minimal or no radiation damage. PMID:27553240

  2. Serial correlation in the Italian futures market

    NASA Astrophysics Data System (ADS)

    Bianco, Simone; Reno, Roberto

    2005-05-01

    We study the serial correlation of high-frequency intraday returns on the Italian stock index futures (FIB30) in the period 2000-2002. We adopt three different methods of analysis: the spectral density via Fast Fourier Transform, Detrended Fluctuation Analysis (DFA) and the Variance Ratio test. We find that intraday autocorrelation is mostly negative for time scales lower than 20 minutes, but we support the efficiency of the Italian futures market.

  3. Infantile Refsum disease: serial evaluation with MRI.

    PubMed

    Cakirer, Sinan; Savas, Mahmut R

    2005-02-01

    Refsum disease is a rare metabolic disorder, which is characterized by the accumulation of phytanic acid in the blood and tissues, including the brain. A variant of this condition that occurs in young children is called infantile Refsum disease. The MRI findings of symmetrical signal change involving the corticospinal tracts, cerebellar dentate nuclei, and corpus callosum are characteristic. We report the serial MRI findings of a child with this rare metabolic disorder.

  4. Lipidic phase membrane protein serial femtosecond crystallography

    PubMed Central

    Johansson, Linda C; Arnlund, David; White, Thomas A; Katona, Gergely; DePonte, Daniel P; Weierstall, Uwe; Doak, R Bruce; Shoeman, Robert L; Lomb, Lukas; Malmerberg, Erik; Davidsson, Jan; Nass, Karol; Liang, Mengning; Andreasson, Jakob; Aquila, Andrew; Bajt, Sasa; Barthelmess, Miriam; Barty, Anton; Bogan, Michael J; Bostedt, Christoph; Bozek, John D; Caleman, Carl; Coffee, Ryan; Coppola, Nicola; Ekeberg, Tomas; Epp, Sascha W; Erk, Benjamin; Fleckenstein, Holger; Foucar, Lutz; Graafsma, Heinz; Gumprecht, Lars; Hajdu, Janos; Hampton, Christina Y; Hartmann, Robert; Hartmann, Andreas; Hauser, Günter; Hirsemann, Helmut; Holl, Peter; Hunter, Mark S; Kassemeyer, Stephan; Kimmel, Nils; Kirian, Richard A; Maia, Filipe R N C; Marchesini, Stefano; Martin, Andrew V; Reich, Christian; Rolles, Daniel; Rudek, Benedikt; Rudenko, Artem; Schlichting, Ilme; Schulz, Joachim; Seibert, M Marvin; Sierra, Raymond G; Soltau, Heike; Starodub, Dmitri; Stellato, Francesco; Stern, Stephan; Strüder, Lothar; Timneanu, Nicusor; Ullrich, Joachim; Wahlgren, Weixiao Y; Wang, Xiaoyu; Weidenspointner, Georg; Wunderer, Cornelia; Fromme, Petra; Chapman, Henry N; Spence, John C H; Neutze, Richard

    2012-01-01

    X-ray free electron laser (X-feL)-based serial femtosecond crystallography is an emerging method with potential to rapidly advance the challenging field of membrane protein structural biology. here we recorded interpretable diffraction data from micrometer-sized lipidic sponge phase crystals of the Blastochloris viridis photosynthetic reaction center delivered into an X-feL beam using a sponge phase micro-jet. PMID:22286383

  5. Lipidic phase membrane protein serial femtosecond crystallography.

    PubMed

    Johansson, Linda C; Arnlund, David; White, Thomas A; Katona, Gergely; Deponte, Daniel P; Weierstall, Uwe; Doak, R Bruce; Shoeman, Robert L; Lomb, Lukas; Malmerberg, Erik; Davidsson, Jan; Nass, Karol; Liang, Mengning; Andreasson, Jakob; Aquila, Andrew; Bajt, Saša; Barthelmess, Miriam; Barty, Anton; Bogan, Michael J; Bostedt, Christoph; Bozek, John D; Caleman, Carl; Coffee, Ryan; Coppola, Nicola; Ekeberg, Tomas; Epp, Sascha W; Erk, Benjamin; Fleckenstein, Holger; Foucar, Lutz; Graafsma, Heinz; Gumprecht, Lars; Hajdu, Janos; Hampton, Christina Y; Hartmann, Robert; Hartmann, Andreas; Hauser, Günter; Hirsemann, Helmut; Holl, Peter; Hunter, Mark S; Kassemeyer, Stephan; Kimmel, Nils; Kirian, Richard A; Maia, Filipe R N C; Marchesini, Stefano; Martin, Andrew V; Reich, Christian; Rolles, Daniel; Rudek, Benedikt; Rudenko, Artem; Schlichting, Ilme; Schulz, Joachim; Seibert, M Marvin; Sierra, Raymond G; Soltau, Heike; Starodub, Dmitri; Stellato, Francesco; Stern, Stephan; Strüder, Lothar; Timneanu, Nicusor; Ullrich, Joachim; Wahlgren, Weixiao Y; Wang, Xiaoyu; Weidenspointner, Georg; Wunderer, Cornelia; Fromme, Petra; Chapman, Henry N; Spence, John C H; Neutze, Richard

    2012-03-01

    X-ray free electron laser (X-FEL)-based serial femtosecond crystallography is an emerging method with potential to rapidly advance the challenging field of membrane protein structural biology. Here we recorded interpretable diffraction data from micrometer-sized lipidic sponge phase crystals of the Blastochloris viridis photosynthetic reaction center delivered into an X-FEL beam using a sponge phase micro-jet.

  6. Lipidic phase membrane protein serial femtosecond crystallography.

    PubMed

    Johansson, Linda C; Arnlund, David; White, Thomas A; Katona, Gergely; Deponte, Daniel P; Weierstall, Uwe; Doak, R Bruce; Shoeman, Robert L; Lomb, Lukas; Malmerberg, Erik; Davidsson, Jan; Nass, Karol; Liang, Mengning; Andreasson, Jakob; Aquila, Andrew; Bajt, Saša; Barthelmess, Miriam; Barty, Anton; Bogan, Michael J; Bostedt, Christoph; Bozek, John D; Caleman, Carl; Coffee, Ryan; Coppola, Nicola; Ekeberg, Tomas; Epp, Sascha W; Erk, Benjamin; Fleckenstein, Holger; Foucar, Lutz; Graafsma, Heinz; Gumprecht, Lars; Hajdu, Janos; Hampton, Christina Y; Hartmann, Robert; Hartmann, Andreas; Hauser, Günter; Hirsemann, Helmut; Holl, Peter; Hunter, Mark S; Kassemeyer, Stephan; Kimmel, Nils; Kirian, Richard A; Maia, Filipe R N C; Marchesini, Stefano; Martin, Andrew V; Reich, Christian; Rolles, Daniel; Rudek, Benedikt; Rudenko, Artem; Schlichting, Ilme; Schulz, Joachim; Seibert, M Marvin; Sierra, Raymond G; Soltau, Heike; Starodub, Dmitri; Stellato, Francesco; Stern, Stephan; Strüder, Lothar; Timneanu, Nicusor; Ullrich, Joachim; Wahlgren, Weixiao Y; Wang, Xiaoyu; Weidenspointner, Georg; Wunderer, Cornelia; Fromme, Petra; Chapman, Henry N; Spence, John C H; Neutze, Richard

    2012-03-01

    X-ray free electron laser (X-FEL)-based serial femtosecond crystallography is an emerging method with potential to rapidly advance the challenging field of membrane protein structural biology. Here we recorded interpretable diffraction data from micrometer-sized lipidic sponge phase crystals of the Blastochloris viridis photosynthetic reaction center delivered into an X-FEL beam using a sponge phase micro-jet. PMID:22286383

  7. Serial FBG sensor network allowing overlapping spectra

    NASA Astrophysics Data System (ADS)

    Abbenseth, S.; Lochmann, S.; Ahrens, A.; Rehm, B.

    2016-05-01

    For structure or material monitoring low impact serial fiber Bragg grating (FBG) networks have attracted increasing research interest. Common sensor networks using wavelength division multiplexing (WDM) for FBG interrogation are limited in their efficiency by the spectral width of their light source, the FBG tuning range and the spectral guard bands. Overlapping spectra are strictly forbidden in this case. Applying time division multiplexing (TDM) or active resonator schemes may overcome these restrictions. However, they introduce other substantial disadvantages like signal roundtrip dependency or sophisticated control of active resonating structures. Code division multiplexing (CDM) as a means of FBG interrogation by simple autocorrelation of appropriate codes has been shown to be superior in this respect. However, it came at the cost of a second spectrometer introducing additional equalization efforts. We demonstrate a new serial FBG sensor network utilizing CDM signal processing for efficient sensor interrogation without the need of a second spectrometer and additional state of polarization (SOP) controlling components. It allows overlapping spectra even when all sensing FBGs are positioned at the same centre wavelength and it shows a high degree of insensitivity to SOP. Sequence inversed keyed (SIK) serial signal processing utilizing quasi-orthogonal balanced codes ensures simple and quick sensor interrogation with high signal-to-interference/noise ratio.

  8. Serial reversal learning in bumblebees (Bombus impatiens).

    PubMed

    Strang, Caroline G; Sherry, David F

    2014-05-01

    Bumblebees are capable of rapidly learning discriminations, but flexibility in bumblebee learning is less well understood. We tested bumblebees (Bombus impatiens) on a serial reversal learning task. A serial reversal task requires learning of an initial discrimination between two differentially rewarded stimuli, followed by multiple reversals of the reward contingency between stimuli. A reduction in errors with repeated reversals in a serial reversal task is an indicator of behavioural flexibility. Bees were housed in a large indoor environment and tested during foraging flights. Testing free-flying bees allowed for large numbers of trials and reversals. All bees were trained to perform a simultaneous discrimination between two colours for a nectar reward, followed by nine reversals of this discrimination. Results showed that bumblebees reduced errors and improved their performance across successive reversals. A reduction in perseverative errors was the major cause of the improvement in performance. Bees showed a slight increase in error rate in their final trials, perhaps as a consequence of increasing proactive interference, but proactive interference may also have contributed to the overall improvement in performance across reversals. Bumblebees are thus capable of behavioural flexibility comparable to that of other animals and may use proactive interference as a mechanism of behavioural flexibility in varying environments.

  9. Serial Pixel Analog-to-Digital Converter

    SciTech Connect

    Larson, E D

    2010-02-01

    This method reduces the data path from the counter to the pixel register of the analog-to-digital converter (ADC) from as many as 10 bits to a single bit. The reduction in data path width is accomplished by using a coded serial data stream similar to a pseudo random number (PRN) generator. The resulting encoded pixel data is then decoded into a standard hexadecimal format before storage. The high-speed serial pixel ADC concept is based on the single-slope integrating pixel ADC architecture. Previous work has described a massively parallel pixel readout of a similar architecture. The serial ADC connection is similar to the state-of-the art method with the exception that the pixel ADC register is a shift register and the data path is a single bit. A state-of-the-art individual-pixel ADC uses a single-slope charge integration converter architecture with integral registers and “one-hot” counters. This implies that parallel data bits are routed among the counter and the individual on-chip pixel ADC registers. The data path bit-width to the pixel is therefore equivalent to the pixel ADC bit resolution.

  10. Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice.

    PubMed

    Roldan-Deamicis, Agustina; Alonso, Eliana; Brie, Belén; Braico, Diego Aguilera; Balogh, Gabriela Andrea

    2016-09-01

    The understanding of the molecular mechanisms of the immune tolerance induced by the tumoral microenvironment is fundamental to prevent cancer development or to treat cancer patients using immunotherapy. Actually, there are investigations about "addressed-drugs" against cancer cells without affecting normal cells. It could be ideal to find selective and specific compounds that only recognize and destroy tumor cells without damaging the host normal cells. For thousands of years, mushrooms have been used for medicinal purposes because of their curative properties. D-Fraction, an extract of Maitake (from the edible Grifola frondosa mushroom), rich in β-glucans, exert notable effects in the immune system. Until now, some published articles suggest that Maitake D-Fraction could have anti-tumoral activity, prevent oncogenesis and metastasis in some tumor types. However, there are no clear data about Maitake D-Fraction action on breast cancer prevention and its exact molecular mechanisms are not yet elucidated. The experiments were performed employing 25 female BALBc mice that were treated with and without Maitake D-Fraction Pro4X or Maitake Standard for 15 days by daily intraperitoneal injection. After treatment period, all mice were implanted with murine tumor cells LM3 to induce mammary tumorigenesis. Animals were checked weekly and killed after 46 days of LM3 transplant; percentage of cancer prevention, rate of tumor growing, and overall survival were determined. Under dissection, the internal organs were evaluated histologically and genetically by RT-PCR. We found that 5 mg/kg per day of Maitake D-Fraction Pro4X, administered dairy during 15 days to BALBc mice was able to block more than 60% breast cancer development. However, Maitake Standard prevents oncogenesis in 26% to respect control. In this work, we found that Maitake D-Fraction Pro4X, administered to BALBc mice, prevents breast carcinogenesis, block tumor invasiveness, reduce angiogenesis, and increase

  11. 25. Black and white photograph, 8 1/4" x 10" on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. Black and white photograph, 8 1/4" x 10" on glossy paper. Night view of the ground floor, central display window showing an exhibit of gas ranges. On bottom right margin in blue ink, "10-8-58", on reverse in rubber stamp black ink, "Indiana Gas Company, Incorporated, 511-513 Honey Creek Drive, P.O. Box 1647, Terre Haute, Indiana 47808". Rubber stamp in blue ink, "Terre Haute Gas Corporation". Property of Indiana Gas Company, located in Terre Haute office. - John T. Beasley Building, 632 Cherry Street (between Sixth & Seventh Streets), Terre Haute, Vigo County, IN

  12. Credit WCT. Original 4"x5" black and white negative is housed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 4"x5" black and white negative is housed in the JPL Archives, Pasadena, California. This image shows the tumble dryer in place as building construction neared completion. The mezzanine railings have not been installed. The scattered debris on the floor and stairs would not be allowed during dryer operation. Compare this view with CA-163-Q-2 and note that the stairs in this 1963 view were moved later; the screen wall was also removed. The reasons for these alterations were not determined (JPL negative no. 381-2831, 18 March 1963) - Jet Propulsion Laboratory Edwards Facility, Oxidizer Dryer Building, Edwards Air Force Base, Boron, Kern County, CA

  13. Credit WCT. Original 2Y4" x 2Y4" color negative is housed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 2-Y4" x 2-Y4" color negative is housed in the JPL Photography Laboratory, Pasadena, California. JPL staff members Harold Anderson and John Morrow cast grain from the 1-gallon BakerPerkins model 4-PU mixer. A 1-pint Baker-Perkins model 2-PX mixer stands to the left in this view (JPL negative no. JPL-10295BC, 27 January 1989) - Jet Propulsion Laboratory Edwards Facility, Mixer & Casting Building, Edwards Air Force Base, Boron, Kern County, CA

  14. Specific heat and thermal conductivity of UCu4+ x Al8- x compounds

    NASA Astrophysics Data System (ADS)

    Nasreen, F.; Torikachvili, M. S.; Kothapalli, K.; Kohama, Y.; Zapf, V. S.; Nakotte, H.

    2013-05-01

    We report on thermal conductivity and specific heat measurements for eight UCu4+ x Al8- x compounds (0 ≤ x ≤ 2.0) as a function of temperature and magnetic field. For this series of compounds, previous magnetic and transport studies indicated a transition from magnetic to a non-magnetic heavy fermion state near x cr ≈ 1.15. This paper presents supplementary specific heat and thermal conductivity studies. The ratio of the specific heat over temperature C/T data on the non magnetic compound with x cr ≈ 1.15 show logarithmic dependence with T, a hallmark of non-Fermi liquid (NFL) behavior due to the proximity of a quantum critical point. Compounds with higher Cu content ( x > x cr ) exhibit unusual temperature scaling in the specific heat possibly due to an increase in disorder between Cu and Al. Thermal conductivity data show stark contrast in the behaviors between the magnetic ( x = 0.5) and non-magnetic compound ( x = 1.75). Our results confirm that a simple free-electron picture is inadequate for the description of the low-temperature thermal conductivity properties in non-magnetic UCu4+ x Al8- x compounds.

  15. Modifications to the 4x7 meter tunnel for acoustic research: Engineering feasibility study

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The NASA-Langley Research Center 4 x 7 Meter Low Speed Wind Tunnel is currently being used for low speed aerodynamics, V/STOL aerodynamics and, to a limited extent, rotorcraft noise research. The deficiencies of this wind tunnel for both aerodynamics and aeroacoustics research have been recognized for some time. Modifications to the wind tunnel are being made to improve the test section flow quality and to update the model cart systems. A further modification of the 4 x 7 Meter Wind Tunnel to permit rotorcraft model acoustics research has been proposed. As a precursor to the design of the proposed modifications, NASA is conducted both in-house and contracted studies to define the acoustic environment within the wind tunnel and to provide recommendations or the reduction of the wind tunnel background noise to a level acceptable to acoustics researchers. One of these studies by an acoustics consultant, has produced the primary reference documents that define the wind tunnel noise sources and outline recommended solutions.

  16. A spatial modality effect in serial memory.

    PubMed

    Tremblay, Sébastien; Parmentier, Fabrice B R; Guérard, Katherine; Nicholls, Alastair P; Jones, Dylan M

    2006-09-01

    In 2 experiments, the authors tested whether the classical modality effect-that is, the stronger recency effect for auditory items relative to visual items-can be extended to the spatial domain. An order reconstruction task was undertaken with four types of material: visual-spatial, auditory-spatial, visual-verbal, and auditory-verbal. Similar serial position curves were obtained regardless of the nature of the to-be-remembered sequences, with the exception that a modality effect was found with spatial as well as with verbal materials. The results are discussed with regard to a number of models of short-term memory.

  17. Serial Femtosecond Crystallography of Membrane Proteins.

    PubMed

    Zhu, Lan; Weierstall, Uwe; Cherezov, Vadim; Liu, Wei

    2016-01-01

    Membrane proteins, including G protein-coupled receptors (GPCRs), constitute the most important drug targets. The increasing number of targets requires new structural information, which has proven tremendously challenging due to the difficulties in growing diffraction-quality crystals. Recent developments of serial femtosecond crystallography at X-ray free electron lasers combined with the use of membrane-mimetic gel-like matrix of lipidic cubic phase (LCP-SFX) for crystal growth and delivery hold significant promise to accelerate structural studies of membrane proteins. This chapter describes the development and current status of the LCP-SFX technology and elaborates its future role in structural biology of membrane proteins. PMID:27553241

  18. CAR-T cells are serial killers

    PubMed Central

    Davenport, Alexander J; Jenkins, Misty R; Ritchie, David S; Prince, H Miles; Trapani, Joseph A; Kershaw, Michael H; Darcy, Phillip K; Neeson, Paul J

    2015-01-01

    Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained long term due to CAR down-regulation after 20 hours. PMID:26587330

  19. Serial cholinesterase estimation in carbamate poisoning.

    PubMed

    Pinakini, K S; Kumar, T S Mohan

    2006-07-01

    Poisoning is one of the most important causes of morbidity and mortality in developing countries like India. Anticholinesterase compounds like organophosphates (OP) and carbamates account for the majority of these poisoning cases because of their easy availability and agricultural use. Carbamates are as popular as OPs as insecticides that often go undiagnosed. A fatal case of carbofuran poisoning is presented where serial cholinesterase estimation played a major role in the diagnosis of the same. The pertinent medical literature on carbofuran poisoning is reviewed. The establishment of poison information center in each state is needed for proper diagnosis and management of poisoning cases.

  20. Automated Serial Sectioning for 3D Reconstruction

    NASA Technical Reports Server (NTRS)

    Alkemper, Jen; Voorhees, Peter W.

    2003-01-01

    Some aspects of an apparatus and method for automated serial sectioning of a specimen of a solder, aluminum, or other relatively soft opaque material are discussed. The apparatus includes a small milling machine (micromiller) that takes precise, shallow cuts (increments of depth as small as 1 micron) to expose successive sections. A microscope equipped with an electronic camera, mounted in a fixed position on the micromiller, takes pictures of the newly exposed specimen surface at each increment of depth. The images are digitized, and the resulting data are subsequently processed to reconstruct three-dimensional (3D) features of the specimen.

  1. Fast serial link using optical fibers

    NASA Astrophysics Data System (ADS)

    Leach, R. W.

    1986-01-01

    In virtue of offering complete immunity from EMI, fiber-optics links for digital data are useful in the isolation of sensitive detecting apparatus from noisy digital computers. Attention is presently given to one such serial data link employing commercially available transmitter, receiver, cable and connector components together with an encoder/decoder circuit employing standard TTL digital logic components. Although designed for high speed fiber-optic operation, the circuit is equally well suited to medium- or low-speed operation over wires and does not have to transmit a separate clock. A data error rate is measured through operation of the link for a lengthy period of time.

  2. Report of the ARL Serials Prices Project. A Compilation of Reports Examining the Serials Prices Problem.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC.

    The rising prices of journals and serials--major information sources for academic and research communities--are explored in this work, which presents two contractor reports on the topic. These two reports are introduced by an overview and summary together with recommendations for further Association of Research Libraries (ARL) action, short…

  3. Concurrent Cognitive Processes in Rat Serial Pattern Learning: Item Memory, Serial Position, and Pattern Structure

    ERIC Educational Resources Information Center

    Muller, Melissa D.; Fountain, Stephen B.

    2010-01-01

    Three experiments examined the processes mediating rat serial pattern learning for rule-consistent versus rule-violating pattern elements ("violation elements"). In all three experiments, rats were trained to press retractable levers in a circular array in a specific sequence for brain-stimulation reward (BSR). Experiment 1 examined the role of…

  4. Measurable neutrino mass scale in A{sub 4}xSU(5)

    SciTech Connect

    Antusch, S.; Spinrath, M.; King, Stephen F.

    2011-01-01

    We propose a supersymmetric A{sub 4}xSU(5) model of quasidegenerate neutrinos which predicts the effective neutrino mass m{sub ee} relevant for neutrinoless double beta decay to be proportional to the neutrino mass scale, thereby allowing its determination approximately independently of unknown Majorana phases. Such a natural quasidegeneracy is achieved by using A{sub 4} family symmetry (as an example of a non-Abelian family symmetry with real triplet representations) to enforce a contribution to the neutrino mass matrix proportional to the identity. Tribimaximal neutrino mixing as well as quark CP violation with {alpha}{approx_equal}90 deg. d a leptonic CP phase {delta}{sub MNS{approx_equal}}90 deg. arise from the breaking of the A{sub 4} family symmetry by the vacuum expectation values of four 'flavon' fields pointing in specific postulated directions in flavor space.

  5. 2. Credit WCT. Original 21/4"x22/4" color negative is housed in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Credit WCT. Original 2-1/4"x2-2/4" color negative is housed in the JPL Archives, Pasadena, California. This view depicts the interior of Test Stand "G" with its "Vibration System consisting of a MB-C210E Electrodynamic Exciter having a maximum sinusoidal force output of 28,000 lbs. and a noload-peak acceleration sine wave of 80 gs." (Quotation based on JPL photo caption in notebook The Jet Propulsion Laboratory Edwards Facility, Jet Propulsion Laboratory, California Institute of Technology, no date; "80 gs" means 80 times the force of gravity.) This machine could be controlled to deliver a wide variety of perturbations (JPL negative no. 344-3802B, 27 February 1981). - Jet Propulsion Laboratory Edwards Facility, Test Stand G, Edwards Air Force Base, Boron, Kern County, CA

  6. Exchange interactions in the intermetallic compounds GdCo 4-xNi xAl

    NASA Astrophysics Data System (ADS)

    Prasongkit, J.; Tang, I. M.

    2004-12-01

    The two sub-lattice model is modified to take into account the presence of two types of transition metal ions in GdCo4-xNixAl. An expression for magnetization is obtained and is used to fit the experimental results of Burzo and Pop (J. Magn. Magn. Mater. 196-97 (1999) 768)). From the values of the molecular field coefficients nij (i, j=Gd, Co or Ni), the values of the exchange interactions JGdGd, JGdCo, JGdNi, JCoCo, JCoNi and JNiNi were found. It is seen that three of them, JGdGd, JNiNi and JGdNi, exhibit clear exponential decreases as the Ni content increases; one of them, JCoCo, exhibits a clear exponential increase. The other two exchange interactions, JGdCo (JCoNi), appear to exhibit a parabolic (inverted parabolic) dependence on the Ni content.

  7. Competing anisotropies on 3d sub-lattice of YNi4-xCoxB compounds

    NASA Astrophysics Data System (ADS)

    Caraballo Vivas, R. J.; Rocco, D. L.; Costa Soares, T.; Caldeira, L.; Coelho, A. A.; Reis, M. S.

    2014-08-01

    The magnetic anisotropy of 3d sub-lattices has an important rule on the overall magnetic properties of hard magnets. Intermetallics alloys with boron (R-Co/Ni-B, for instance) belong to those hard magnets family and are useful objects to help to understand the magnetic behavior of 3d sub-lattice, specially when the rare earth ions R do not have magnetic nature, like YCo4B ferromagnetic material. Interestingly, YNi4B is a paramagnetic material and Ni ions do not contribute to the magnetic anisotropy. We focused therefore our attention to YNi4-xCoxB series, with x = 0, 1, 2, 3, and 4. The magnetic anisotropy of these compounds is deeper described using statistical and preferential models of Co occupation among the possible Wyckoff positions into the CeCo4B type hexagonal structure. We found that the preferential model is the most suitable to explain the magnetization experimental data.

  8. Malingering, coaching, and the serial position effect.

    PubMed

    Suhr, Julie A

    2002-01-01

    The normal pattern of performance on list-learning tasks is to recall more words from the beginning (primacy) and end (recency) of the list. This pattern is also seen in patients with closed head injury, but malingerers tend to recall less words from the beginning of word lists, leading to a suppressed primacy effect. The present study examined this pattern on both learning trials and delayed recall of the Auditory Verbal Learning Test (AVLT) in 34 persons performing with normal effort, 38 naive malingerers, 33 warned malingerers, and 29 head-injured patients. Both malingering groups had lower scores on the primacy portion of the list during learning trials, while normals and head-injured patients had normal serial position curves. During delayed recall, normals and head-injured patients did better than the two malingering groups on middle and recency portions of the list. Findings suggest that the serial position effect during learning trials may be a useful pattern of performance to watch for when suspicious of malingering.

  9. Estimation method for serial dilution experiments.

    PubMed

    Ben-David, Avishai; Davidson, Charles E

    2014-12-01

    Titration of microorganisms in infectious or environmental samples is a corner stone of quantitative microbiology. A simple method is presented to estimate the microbial counts obtained with the serial dilution technique for microorganisms that can grow on bacteriological media and develop into a colony. The number (concentration) of viable microbial organisms is estimated from a single dilution plate (assay) without a need for replicate plates. Our method selects the best agar plate with which to estimate the microbial counts, and takes into account the colony size and plate area that both contribute to the likelihood of miscounting the number of colonies on a plate. The estimate of the optimal count given by our method can be used to narrow the search for the best (optimal) dilution plate and saves time. The required inputs are the plate size, the microbial colony size, and the serial dilution factors. The proposed approach shows relative accuracy well within ±0.1log10 from data produced by computer simulations. The method maintains this accuracy even in the presence of dilution errors of up to 10% (for both the aliquot and diluent volumes), microbial counts between 10(4) and 10(12) colony-forming units, dilution ratios from 2 to 100, and plate size to colony size ratios between 6.25 to 200.

  10. Serial dilution microchip for cytotoxicity test

    NASA Astrophysics Data System (ADS)

    Bang, Hyunwoo; Lim, Sun Hee; Lee, Young Kyung; Chung, Seok; Chung, Chanil; Han, Dong-Chul; Chang, Jun Keun

    2004-08-01

    Today's pharmaceutical industry is facing challenges resulting from the vast increases in sample numbers produced by high-throughput screening (HTS). In addition, the bottlenecks created by increased demand for cytotoxicity testing (required to assess compound safety) are becoming a serious problem. We have developed a polymer PDMS (polydimethylsiloxane) based microfluidic device that can perform a cytotoxicity test in a rapid and reproducible manner. The concept that the device includes is well adjustable to automated robots in huge HTS systems, so we can think of it as a potential dilution and delivery module. Cytotoxicity testing is all about the dilution and dispensing of a drug sample. Previously, we made a PDMS based microfluidic device which automatically and precisely diluted drugs with a buffer solution with serially increasing concentrations. This time, the serially diluted drug solution was directly delivered to 96 well plates for cytotoxicity testing. Cytotoxic paclitaxel solution with 2% RPMI 1640 has been used while carrying out cancerous cell based cytotoxicity tests. We believe that this rapid and robust use of the PDMS microchip will overcome the growing problem in cytotoxicity testing for HTS.

  11. [Linkage analysis of serial sex crimes].

    PubMed

    Yokota, Kaeko; Watanabe, Kazumi; Wachi, Taeko; Otsuka, Yusuke; Kuraishi, Hiroki; Fujita, Goro

    2015-08-01

    The purpose of this study was twofold: first, to create an index for a behavioral linkage analysis of serial sex crimes, and second, to construct a predictive model for the analysis. Data on 720 sex crimes (rape, indecent assault) committed by 360 offenders arrested between 1993 and 2005 throughout Japan were collected. The following seven behaviors were examined during a series of analyses aimed at illustrating the effectiveness of crime linkage in serial sex crimes: victim age group, area type, publicness of offense site, weapon, time, contact method, and day of the week. The results indicated that six of the seven behaviors (excluding "day of the week") significantly distinguished between linked and unlinked crime pairs. Under a logistic regression of these six variables, which were dichotomously coded in terms of the concordance or discordance between each pair of incidents, the area under the receiver operating characteristic (ROC) curve was 0.85 (95% CI = 0.82-0.87), indicating a high level of discriminative accuracy in identifying disparate sex crimes committed by the same person. PMID:26402952

  12. Data Exploration Toolkit for serial diffraction experiments

    SciTech Connect

    Zeldin, Oliver B.; Brewster, Aaron S.; Hattne, Johan; Uervirojnangkoorn, Monarin; Lyubimov, Artem Y.; Zhou, Qiangjun; Zhao, Minglei; Weis, William I.; Sauter, Nicholas K.; Brunger, Axel T.

    2015-02-01

    This paper describes a set of tools allowing experimentalists insight into the variation present within large serial data sets. Ultrafast diffraction at X-ray free-electron lasers (XFELs) has the potential to yield new insights into important biological systems that produce radiation-sensitive crystals. An unavoidable feature of the ‘diffraction before destruction’ nature of these experiments is that images are obtained from many distinct crystals and/or different regions of the same crystal. Combined with other sources of XFEL shot-to-shot variation, this introduces significant heterogeneity into the diffraction data, complicating processing and interpretation. To enable researchers to get the most from their collected data, a toolkit is presented that provides insights into the quality of, and the variation present in, serial crystallography data sets. These tools operate on the unmerged, partial intensity integration results from many individual crystals, and can be used on two levels: firstly to guide the experimental strategy during data collection, and secondly to help users make informed choices during data processing.

  13. Breaking the indexing ambiguity in serial crystallography.

    PubMed

    Brehm, Wolfgang; Diederichs, Kay

    2014-01-01

    In serial crystallography, a very incomplete partial data set is obtained from each diffraction experiment (a `snapshot'). In some space groups, an indexing ambiguity exists which requires that the indexing mode of each snapshot needs to be established with respect to a reference data set. In the absence of such re-indexing information, crystallographers have thus far resorted to a straight merging of all snapshots, yielding a perfectly twinned data set of higher symmetry which is poorly suited for structure solution and refinement. Here, two algorithms have been designed for assembling complete data sets by clustering those snapshots that are indexed in the same way, and they have been tested using 15,445 snapshots from photosystem I [Chapman et al. (2011), Nature (London), 470, 73-77] and with noisy model data. The results of the clustering are unambiguous and enabled the construction of complete data sets in the correct space group P63 instead of (twinned) P6322 that researchers have been forced to use previously in such cases of indexing ambiguity. The algorithms thus extend the applicability and reach of serial crystallography.

  14. Galileo - The Serial-Production AIT Challenge

    NASA Technical Reports Server (NTRS)

    Ragnit, Ulrike; Brunner, Otto

    2008-01-01

    The Galileo Project is one of the most demanding projects of ESA, being Europe's autarkic navigation system and a constellation composed of 30 satellites. This presentation points out the different phases of the project up to the full operational capability and the corresponding launch options with respect to launch vehicles as well as launch configurations. One of the biggest challenges is to set up a small serial 'production line' for the overall integration and test campaign of satellites. This production line demands an optimization of all relevant tasks, taking into account also backup and recovery actions. A comprehensive AIT concept is required, reflecting a tightly merged facility layout and work flow design. In addition a common data management system is needed to handle all spacecraft related documentation and to have a direct input-out flow for all activities, phases and positions at the same time. Process optimization is a well known field of engineering in all small high tech production lines, nevertheless serial production of satellites are still not the daily task in space business and therefore new concepts have to be put in place. Therefore, and in order to meet the satellites overall system optimization, a thorough interface between unit/subsystem manufacturing and satellite AIT must be realized to ensure a smooth flow and to avoid any process interruption, which would directly lead to a schedule impact.

  15. [Linkage analysis of serial sex crimes].

    PubMed

    Yokota, Kaeko; Watanabe, Kazumi; Wachi, Taeko; Otsuka, Yusuke; Kuraishi, Hiroki; Fujita, Goro

    2015-08-01

    The purpose of this study was twofold: first, to create an index for a behavioral linkage analysis of serial sex crimes, and second, to construct a predictive model for the analysis. Data on 720 sex crimes (rape, indecent assault) committed by 360 offenders arrested between 1993 and 2005 throughout Japan were collected. The following seven behaviors were examined during a series of analyses aimed at illustrating the effectiveness of crime linkage in serial sex crimes: victim age group, area type, publicness of offense site, weapon, time, contact method, and day of the week. The results indicated that six of the seven behaviors (excluding "day of the week") significantly distinguished between linked and unlinked crime pairs. Under a logistic regression of these six variables, which were dichotomously coded in terms of the concordance or discordance between each pair of incidents, the area under the receiver operating characteristic (ROC) curve was 0.85 (95% CI = 0.82-0.87), indicating a high level of discriminative accuracy in identifying disparate sex crimes committed by the same person.

  16. Serial Cognition and Personality in Macaques

    PubMed Central

    Altschul, Drew M.; Terrace, Herbert S.; Weiss, Alexander

    2016-01-01

    We examined the associations between serial cognition and personality in rhesus macaques (Macaca mulatta). Nine macaques were tested on a simultaneous chaining task to assess their cognitive abilities. They were also rated for personality traits and scored according to a previously extracted six component structure derived from free-ranging rhesus macaques. Friendliness and Openness were positively associated with good performance on three measures of accuracy on the serial learning task: Progress, Error, and Rewarded (i.e., correctly completed) Trials. Faster Reaction Times were associated with lower Friendliness and higher Confidence, as well as higher Openness when only correct responses were analyzed. We also used regularized exploratory factor analysis to extract two, three, four, five, and six factor structures, and found consistent associations between accuracy and single factors within each of these structures. Prior results on intelligence in other nonhuman primate species have focused on basic intelligence tests; this study demonstrates that more complex, abstract cognitive tasks can be used to assess intelligence and personality in nonhuman primates. PMID:27158661

  17. Thermal and electrochemical behavior of Cu4-xLixS2 (x=1, 2, 3) phases

    NASA Astrophysics Data System (ADS)

    Chen, Erica M.; Poudeu, Pierre F. P.

    2015-12-01

    Several compositions of the Cu4-xLixS2 (x=1, 2, 3) series were synthesized via solid-state reaction of the elements. The structural stability at various temperatures and the effect of Li:Cu ratio on the thermal conductivity and the electrochemical performance of Cu4-xLixS2/Li half-cells during charge-discharge process were investigated. Differential scanning calorimetry (DSC) measurements showed a sharp endothermic peak at 140 °C for Cu4-xLixS2 samples with x=1 and 2, which is ascribed to a structural phase transition. X-ray diffraction (XRD) measurements on various Cu4-xLixS2 samples at temperatures below and above 140 °C indicated a structural phase transition from the room temperature low-symmetry structure to the high temperature cubic structure of Cu2S. The thermal conductivity of Cu4-xLixS2 samples decreases with decreasing Cu:Li ratio and with increasing temperature. The thermal conductivity of Cu4-xLixS2 samples at room temperature decreases from 1.2 W/m K for Cu:Li=3:1 to 0.7 W/m K for Cu:Li=1:3. Cyclic voltammetry of Cu4-xLixS2/Li half-cells showed that high discharge capacity (165 mA h g-1) and stable reversible charge-discharge process is observed for Cu:Li=2:2, whereas other Cu:Li ratios lead to low discharge capacity and poor reversibility. The electrochemical behavior of Cu4-xLixS2/Li half-cells is rationalized by taking into account the competing reactions of Li+ ions with CuS and Cu2S during discharge.

  18. Representation of the serial killer on the Italian Internet.

    PubMed

    Villano, P; Bastianoni, P; Melotti, G

    2001-10-01

    The representation of serial killers was examined from the analysis of 317 Web pages in the Italian language to study how the psychological profiles of serial killers are described on the Italian Internet. The correspondence analysis of the content of these Web pages shows that in Italy the serial killer is associated with words such as "monster" and "horror," which suggest and imply psychological perversion and aberrant acts. These traits are peculiar for the Italian scenario.

  19. CAMAC serial highway interface for the LSI-11

    SciTech Connect

    Lau, N.H.

    1980-04-03

    A CAMAC Serial Highway Interface has been designed for the Local Control and Instrumentation System of the Mirror Fusion Test Facility. There are over 50 distinguishable systems in the facility, each of which consists of the LSI-11 computer, fiber optic communication links, and the CAMAC system. The LSI-11 computer includes a 32k memory, serial modem interface and the CAMAC Serial Highway Interface.

  20. Representation of the serial killer on the Italian Internet.

    PubMed

    Villano, P; Bastianoni, P; Melotti, G

    2001-10-01

    The representation of serial killers was examined from the analysis of 317 Web pages in the Italian language to study how the psychological profiles of serial killers are described on the Italian Internet. The correspondence analysis of the content of these Web pages shows that in Italy the serial killer is associated with words such as "monster" and "horror," which suggest and imply psychological perversion and aberrant acts. These traits are peculiar for the Italian scenario. PMID:11783573

  1. Malignant sex and aggression: an overview of serial sexual homicide.

    PubMed

    Myers, W C; Reccoppa, L; Burton, K; McElroy, R

    1993-01-01

    Serial murderers have attracted considerable attention in the popular press and criminal justice field, but scientific literature about these individuals is limited. This article provides an overview, from a psychiatric perspective, of serial sexual homicide, one type of serial killing. Characteristics of this type of murder and of these offenders are discussed. Defining qualities and diagnoses applicable to serial sexual killers are reviewed. Various etiologic theories are discussed, with emphasis on the role of fantasy and psychodynamic explanations. Governmental agencies involved in combating this type of crime, along with the role of mental health professionals in criminal profiling, are presented. Finally, the authors explore the reaction of society to this phenomenon.

  2. A psychological profile of a serial killer: a case report.

    PubMed

    Dogra, T D; Leenaars, Antoon A; Chadha, R K; Manju, Mehta; Lalwani, Sanjeev; Sood, Mamta; Lester, David; Raina, Anupuma; Behera, C

    2012-01-01

    Serial killers have always fascinated society. A serial killer is typically defined as a perpetrator who murders three or more people over a period of time. Most reported cases of serial killers come from the United States and Canada. In India, there are few reported cases. We present, to the best of our knowledge, the first Indian case in the literature. The present case is of a 28-year-old man, Surinder Koli. The Department of Forensic Medicine & Toxicology, All India Institute of Medical Sciences, New Delphi handled the forensic study. We present a most unique psychological investigation into the mind of a serial killer.

  3. Malignant sex and aggression: an overview of serial sexual homicide.

    PubMed

    Myers, W C; Reccoppa, L; Burton, K; McElroy, R

    1993-01-01

    Serial murderers have attracted considerable attention in the popular press and criminal justice field, but scientific literature about these individuals is limited. This article provides an overview, from a psychiatric perspective, of serial sexual homicide, one type of serial killing. Characteristics of this type of murder and of these offenders are discussed. Defining qualities and diagnoses applicable to serial sexual killers are reviewed. Various etiologic theories are discussed, with emphasis on the role of fantasy and psychodynamic explanations. Governmental agencies involved in combating this type of crime, along with the role of mental health professionals in criminal profiling, are presented. Finally, the authors explore the reaction of society to this phenomenon. PMID:8054674

  4. A psychological profile of a serial killer: a case report.

    PubMed

    Dogra, T D; Leenaars, Antoon A; Chadha, R K; Manju, Mehta; Lalwani, Sanjeev; Sood, Mamta; Lester, David; Raina, Anupuma; Behera, C

    2012-01-01

    Serial killers have always fascinated society. A serial killer is typically defined as a perpetrator who murders three or more people over a period of time. Most reported cases of serial killers come from the United States and Canada. In India, there are few reported cases. We present, to the best of our knowledge, the first Indian case in the literature. The present case is of a 28-year-old man, Surinder Koli. The Department of Forensic Medicine & Toxicology, All India Institute of Medical Sciences, New Delphi handled the forensic study. We present a most unique psychological investigation into the mind of a serial killer. PMID:23115894

  5. A nanoliter microfluidic serial dilution bioreactor.

    PubMed

    Gu, Guo-Yue; Lee, Yi-Wei; Chiang, Chih-Chung; Yang, Ya-Tang

    2015-07-01

    Bacterial culture is a basic technique in both fundamental and applied microbiology. The excessive reagent consumption and laborious maintenance of bulk bioreactors for microbial culture have prompted the development of miniaturized on-chip bioreactors. With the minimal choice of two compartments (N = 2) and discrete time, periodic dilution steps, we realize a microfluidic bioreactor that mimics macroscopic serial dilution transfer culture. This device supports automated, long-term microbial cultures with a nanoliter-scale working volume and real-time monitoring of microbial populations at single-cell resolution. Because of the high surface-to-volume ratio, the device also operates as an effective biofilm-flow reactor to support cogrowth of planktonic and biofilm populations. We expect that such devices will open opportunities in many fields of microbiology.

  6. Data Exploration Toolkit for serial diffraction experiments

    DOE PAGESBeta

    Zeldin, Oliver B.; Brewster, Aaron S.; Hattne, Johan; Uervirojnangkoorn, Monarin; Lyubimov, Artem Y.; Zhou, Qiangjun; Zhao, Minglei; Weis, William I.; Sauter, Nicholas K.; Brunger, Axel T.

    2015-01-23

    Ultrafast diffraction at X-ray free-electron lasers (XFELs) has the potential to yield new insights into important biological systems that produce radiation-sensitive crystals. An unavoidable feature of the 'diffraction before destruction' nature of these experiments is that images are obtained from many distinct crystals and/or different regions of the same crystal. Combined with other sources of XFEL shot-to-shot variation, this introduces significant heterogeneity into the diffraction data, complicating processing and interpretation. To enable researchers to get the most from their collected data, a toolkit is presented that provides insights into the quality of, and the variation present in, serial crystallography datamore » sets. These tools operate on the unmerged, partial intensity integration results from many individual crystals, and can be used on two levels: firstly to guide the experimental strategy during data collection, and secondly to help users make informed choices during data processing.« less

  7. Data Exploration Toolkit for serial diffraction experiments

    PubMed Central

    Zeldin, Oliver B.; Brewster, Aaron S.; Hattne, Johan; Uervirojnangkoorn, Monarin; Lyubimov, Artem Y.; Zhou, Qiangjun; Zhao, Minglei; Weis, William I.; Sauter, Nicholas K.; Brunger, Axel T.

    2015-01-01

    Ultrafast diffraction at X-ray free-electron lasers (XFELs) has the potential to yield new insights into important biological systems that produce radiation-sensitive crystals. An unavoidable feature of the ‘diffraction before destruction’ nature of these experiments is that images are obtained from many distinct crystals and/or different regions of the same crystal. Combined with other sources of XFEL shot-to-shot variation, this introduces significant heterogeneity into the diffraction data, complicating processing and interpretation. To enable researchers to get the most from their collected data, a toolkit is presented that provides insights into the quality of, and the variation present in, serial crystallography data sets. These tools operate on the unmerged, partial intensity integration results from many individual crystals, and can be used on two levels: firstly to guide the experimental strategy during data collection, and secondly to help users make informed choices during data processing. PMID:25664746

  8. Serial murder by children and adolescents.

    PubMed

    Myers, Wade C

    2004-01-01

    Six cases of serial murder by children and adolescents spanning the past 150 years are presented. The available literature pertaining to this area is reviewed. Each of these six offenders committed sexually homicidal behavior as demonstrated by their expression of erotic interest or engagement in overt sexual behavior at the crime scenes. From a DSM-IV-TR perspective they all exhibited signs of sexual sadism, and their crime characteristics reflected behavior of a more predatory than affective nature. Hands on methods of killing were preferred, i.e., cutting, stabbing, or strangulation. These crimes are extremely rare. Case reports in this area are encouraged to advance our knowledge of these youths. PMID:15211557

  9. Serial Endosymbiotic Theory (set): the biosemiotic update.

    PubMed

    Witzany, Günther

    2006-01-01

    The Serial Endosymbiotic Theory explains the origin of nucleated eukaryotic cells by a merging of archaebacterial and eubacterial cells. The paradigmatic change is that the driving force behind evolution is not ramification but merging. Lynn Margulis describes the symbiogenetic processes in the language of mechanistic biology in such terms as "merging", "fusion", and "incorporation". Biosemiotics argues that all cell-cell interactions are (rule-governed) sign-mediated interactions, i.e., communication processes. As the description of plant communication demonstrates, the biosemiotic approach is not limited to the level of molecular biology, but is also helpful in examining all sign-mediated interactions between organisms on the phenotypic level. If biosemiotics also uses the notions of "language" and "communication" to describe non-human sign-mediated interactions, then the underlying scientific justification of such usage should be critically considered. Therefore, I summarize the history of this discussion held between 1920 and 1980 and present its result, the pragmatic turn.

  10. Price Index for U.S. Serial Services 1991.

    ERIC Educational Resources Information Center

    Shroyer, Andrew

    1991-01-01

    Presents the annual survey of prices for U.S. serial services for 1991 which was compiled in conjunction with the Faxon Company. Comparative data for 1977-91 are included for the areas of business, humanities, law, science and technology, social science, and documents, as well as serial services from the H.W. Wilson Company. (LRW)

  11. Serials Control and Deselection Projects. SPEC Kit 147.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This Systems and Procedures Exchange Center (SPEC) Kit on serials control and deselection projects provides a timely review of the efforts of research libraries to control the increasing costs of serial subscriptions. This kit contains documents from 13 libraries: University of California at Los Angeles and Riverside; Universities of Florida,…

  12. A Management Information System for Serials and Continuations.

    ERIC Educational Resources Information Center

    Olson, Nancy B.; Lester, Daniel W.

    Cutbacks in funding and personnel required the Mankato State College Library to gain more effective control over its serials collection. The task was to integrate the various data, some unrecorded, on standing orders and serials holdings and to produce for the library directors specialized lists of many types: all titles ordered from a specific…

  13. Serial Rapid Naming Skills in Children with Reading Disabilities.

    ERIC Educational Resources Information Center

    Snyder, Lynn S.; Downey, Doris M.

    1995-01-01

    This study found that 30 children with reading disability (RD) performed more poorly than 30 children with normal reading achievement on tasks of serial rapid naming, verbal fluency, letter-based word retrieval, and articulatory speed. RD children had significantly longer reaction times and production durations on the serial naming task. Findings…

  14. Speech and Language Processing Mechanisms in Verbal Serial Recall

    ERIC Educational Resources Information Center

    Allen, Richard; Hulme, Charles

    2006-01-01

    We report two experiments examining the role of concreteness and word phonological neighborhood characteristics on immediate serial recall. In line with previous findings concreteness, word frequency, and larger neighborhood size are associated with better serial recall. Both concreteness and word neighborhood size were also positively associated…

  15. Infants' Memory Processing of a Serial List: List Length Effects.

    ERIC Educational Resources Information Center

    Gulya, Michele; Sweeney, Becky; Rovee-Collier, Carolyn

    1999-01-01

    Three experiments demonstrated that increasing the length of a mobile serial list impaired 6-month olds' memory for serial order. Findings indicated that the primacy effect was absent on a 24-hour delayed recognition test and was exhibited on a reactivation test, adding to growing evidence that young infants possess two functionally distinct…

  16. List Onset and Isolation in Continuous Serial Learning

    ERIC Educational Resources Information Center

    Lippman, Louis G.

    1974-01-01

    This experiment attempted to obtain an estimate of perceptual isolation effects when the isolated item was the only distinctive feature in the list and to obtain data on continuous serial learning in order that isolation and serial-position effects could be compared directly. (Author/RK)

  17. Listening to French and the Serial Position Effect.

    ERIC Educational Resources Information Center

    Garrott, Carl L.

    This study sought to determine the extent of the serial position effect in listening to French and to specify the relationship between problem areas in listening to French and the position effect. The study addressed three hypotheses relative to the serial position effect and listening to French: (1) Was there a significant difference between the…

  18. Forgetting in Immediate Serial Recall: Decay, Temporal Distinctiveness, or Interference?

    ERIC Educational Resources Information Center

    Oberauer, Klaus; Lewandowsky, Stephan

    2008-01-01

    Three hypotheses of forgetting from immediate memory were tested: time-based decay, decreasing temporal distinctiveness, and interference. The hypotheses were represented by 3 models of serial recall: the primacy model, the SIMPLE (scale-independent memory, perception, and learning) model, and the SOB (serial order in a box) model, respectively.…

  19. Serials Information on CD-ROM: A Reference Perspective.

    ERIC Educational Resources Information Center

    Karch, Linda S.

    1990-01-01

    Describes Ulrich's PLUS (a CD-ROM version of Ulrich's serials directories) and EBSCO's CD-ROM version of "The Serials Directory," and compares the two in terms of their use as reference tools. Areas discussed include database content, user aids, system features, search features, and a comparison of search results. Equipment requirements for both…

  20. Indexing Serialized Fiction: May the Force Be with You.

    ERIC Educational Resources Information Center

    Barr, Melissa M.

    The adult novel offers indexers an unusual opportunity to create a serialized fiction index. This research paper involved designing and creating a Character Index, Thesaurus, Glossary, and Abstract (with descriptors) for 21 novels based on the "Star Wars" movies. The novels are an unusual example of serialized fiction featuring main characters,…

  1. Antisocial personality disorder, sexual sadism, malignant narcissism, and serial murder.

    PubMed

    Geberth, V J; Turco, R N

    1997-01-01

    This paper examines the research on serial murder and its relationship to antisocial personality disorder and sexual sadism. The concept of malignant narcissism is also discussed. Case studies of serial killers are examined regarding the nature of sexual violation and crime scene behavior.

  2. Serial Magnetization Transfer Imaging in Acute Optic Neuritis

    ERIC Educational Resources Information Center

    Hickman, S. J.; Toosy, A. T.; Jones, S. J.; Altmann, D. R.; Miszkiel, K. A.; MacManus, D. G.; Barker, G. J.; Plant, G. T.; Thompson, A. J.; Miller, D.H.

    2004-01-01

    In serial studies of multiple sclerosis lesions, reductions in magnetization transfer ratio (MTR) are thought to be due to demyelination and axonal loss, with later rises due to remyelination. This study followed serial changes in MTR in acute optic neuritis in combination with clinical and electrophysiological measurements to determine if the MTR…

  3. Retrospective Revaluation Effects Following Serial Compound Training and Target Extinction

    ERIC Educational Resources Information Center

    Effting, Marieke; Vervliet, Bram; Kindt, Merel

    2010-01-01

    Using a conditioned suppression task, two experiments examined retrospective revaluation effects after serial compound training in a release from overshadowing design. In Experiment 1, serial X [right arrow] A+ training produced suppression to target A, which was enhanced when preceded by feature X, whereas X by itself elicited no suppression.…

  4. Antisocial personality disorder, sexual sadism, malignant narcissism, and serial murder.

    PubMed

    Geberth, V J; Turco, R N

    1997-01-01

    This paper examines the research on serial murder and its relationship to antisocial personality disorder and sexual sadism. The concept of malignant narcissism is also discussed. Case studies of serial killers are examined regarding the nature of sexual violation and crime scene behavior. PMID:8988574

  5. The Effect of Concurrent Semantic Categorization on Delayed Serial Recall

    ERIC Educational Resources Information Center

    Acheson, Daniel J.; MacDonald, Maryellen C.; Postle, Bradley R.

    2011-01-01

    The influence of semantic processing on the serial ordering of items in short-term memory was explored using a novel dual-task paradigm. Participants engaged in 2 picture-judgment tasks while simultaneously performing delayed serial recall. List material varied in the presence of phonological overlap (Experiments 1 and 2) and in semantic content…

  6. Using a Text-Processing Language for Serial Record Conversion.

    ERIC Educational Resources Information Center

    Lowrey, James R.; Hardiman, Paul V.

    1985-01-01

    Describes the automation of the machine-readable library serials file at Golda Meir Library, University of Wisconsin-Milwaukee. Highlights include purchase of the PERLINE/BOOKLINE system including a MARC interface module called MICA, five main aspects of the problem posed by the library serials conversion project, and use of the text-processing…

  7. Multiple Serial List Learning with Two Mnemonic Techniques.

    ERIC Educational Resources Information Center

    Marston, Paul T.; Young, Robert K.

    The classic mnemonic for learning serial lists, the method of loci, and its modern counterpart, the peg system, were compared by having subjects learn three 20-item serial lists. In addition to the type of mnemonic training, list imagery was either high (rated 6-7) or medium (rated 4-5), and instructions were either progressive elaboration (e.g.,…

  8. Initiation of a passivated interface between hafnium oxide and In(Ga)As(0 0 1)-(4x2).

    PubMed

    Clemens, Jonathon B; Bishop, Sarah R; Lee, Joon Sung; Kummel, Andrew C; Droopad, Ravi

    2010-06-28

    Hafnium oxide interfaces were studied on two related group III rich semiconductor surfaces, InAs(0 0 1)-(4x2) and In(0.53)Ga(0.47)As(0 0 1)-(4x2), via two different methods: reactive oxidation of deposited Hf metal and electron beam deposition of HfO(2). The interfaces were investigated with scanning tunneling microscopy and spectroscopy (STS). Single Hf atom chemisorption sites were identified that are resistant to oxidation by O(2), but Hf islands are reactive to O(2). After e(-) beam deposition of <1 ML of HfO(2), single chemisorption sites were identified. At low coverage (<1 ML), the n-type and p-type HfO(2)/InGaAs(0 0 1)-(4x2) interfaces show p-type character in STS, which is typical of clean InGaAs(0 0 1)-(4x2). After annealing below 200 degrees C, full coverage HfO(2)/InGaAs(0 0 1)-(4x2) (1-3 ML) has the surface Fermi level shifted toward the conduction band minimum for n-type InGaAs, but near the valence band maximum for p-type InGaAs. This is consistent with the HfO(2)/InGaAs(0 0 1)-(4x2) interface being at least partially unpinned, i.e., a low density of states in the band gap. The partially unpinned interface results from the modest strength of the bonding between HfO(2) and InGaAs(0 0 1)-(4x2) that prevents substrate atom disruption. The fortuitous structure of HfO(2) on InAs(0 0 1)-(4x2) and InGaAs(0 0 1)-(4x2) allows for the elimination of the partially filled dangling bonds on the surface, which are usually responsible for Fermi level pinning.

  9. Initiation of a passivated interface between hafnium oxide and In(Ga)As(0 0 1)-(4x2)

    SciTech Connect

    Clemens, Jonathon B.; Bishop, Sarah R.; Kummel, Andrew C.; Lee, Joon Sung

    2010-06-28

    Hafnium oxide interfaces were studied on two related group III rich semiconductor surfaces, InAs(0 0 1)-(4x2) and In{sub 0.53}Ga{sub 0.47}As(0 0 1)-(4x2), via two different methods: reactive oxidation of deposited Hf metal and electron beam deposition of HfO{sub 2}. The interfaces were investigated with scanning tunneling microscopy and spectroscopy (STS). Single Hf atom chemisorption sites were identified that are resistant to oxidation by O{sub 2}, but Hf islands are reactive to O{sub 2}. After e{sup -} beam deposition of <<1 ML of HfO{sub 2}, single chemisorption sites were identified. At low coverage (<1 ML), the n-type and p-type HfO{sub 2}/InGaAs(0 0 1)-(4x2) interfaces show p-type character in STS, which is typical of clean InGaAs(0 0 1)-(4x2). After annealing below 200 deg. C, full coverage HfO{sub 2}/InGaAs(0 0 1)-(4x2) (1-3 ML) has the surface Fermi level shifted toward the conduction band minimum for n-type InGaAs, but near the valence band maximum for p-type InGaAs. This is consistent with the HfO{sub 2}/InGaAs(0 0 1)-(4x2) interface being at least partially unpinned, i.e., a low density of states in the band gap. The partially unpinned interface results from the modest strength of the bonding between HfO{sub 2} and InGaAs(0 0 1)-(4x2) that prevents substrate atom disruption. The fortuitous structure of HfO{sub 2} on InAs(0 0 1)-(4x2) and InGaAs(0 0 1)-(4x2) allows for the elimination of the partially filled dangling bonds on the surface, which are usually responsible for Fermi level pinning.

  10. Thermal and electrical transport properties of UCu4+xAl8-x

    NASA Astrophysics Data System (ADS)

    Nasreen, Farzana; Torikachvilli, Milton; Kothapalli, Karunakar; Zapf, Vivien; Nakotte, Heinz

    2009-10-01

    The UCu4+xAl8-x family crystallizes in the tetragonal ThMn12 - type structure in the range from 0.1<= x<= 1.95. It has been reported that the Cu-poor compounds show antiferromagnetic long-range order, followed by a transition at x=1.15 to a heavy fermion behavior. We report on the results of thermal conductivity and the Seebeck coefficient as a function of temperature (1.8-300K). Thermal conductivity data are consistent with previously published electrical resistivity data. The Seebeck coefficient measurements, S, confirm the peaks at TN for the antiferromagnetic compounds. We also measured electrical resistivity as function of very low temperature from 75mK to 4K and in magnetic field up to 6Tesla for UCu6Al2, UCu5.75Al6.25, UCu5.5Al6.5 and UCu5.25Al6.75. UCu5.75Al6.25 which was reported as non-Fermi liquid (NFL) compound shows quantum critical point induced by magnetic field. These results provide some insight about the underlying mechanisms to the apparent NFL behavior in UCu5.75Al6.25 compound.

  11. Thermoelectric properties of La z Fe4- x Ni x Sb12 skutterudites

    NASA Astrophysics Data System (ADS)

    Lee, Woo-Man; Shin, Dong-Kil; Kim, Il-Ho

    2015-01-01

    p-Type La z Fe4- x Ni x Sb12 (0.8 ≤ z ≤ 1.0, 0.25 ≤ x ≤ 0.5) skutterudites were prepared, and the effects of La filling and Ni doping (charge compensation) on their transport and thermoelectric properties were examined. While X-ray diffraction analysis revealed the successful formation of the skutterudite phase, small amounts of secondary phases, including FeSb2 and Sb, were produced. However, when La and Ni contents were increased, no secondary phases were shown for the La0.9-1.0Fe3.5Ni0.5Sb12 specimen. This meant that the La filling fraction needed to be high to stabilize the skutterudite structure if the charge compensation with Ni was deficient. All samples had positive Hall coefficients and Seebeck coefficients, and the carrier concentration ranged from 8.72 × 1020 cm-3 to 2.39 × 1021 cm-3. The electrical conductivity and the thermal conductivity decreased and the Seebeck coefficient increased with increasing La and Ni contents due to the decreased carrier concentration. La0.9Fe3.5Ni0.5Sb12 achieved a maximum dimensionless figure of merit, ZT of 0.82 at 723 K on the basis of the high power factor (2.8 mWm-1K-2) and the low thermal conductivity (2.4 Wm-1K-1).

  12. Thermoelectric transport in the layered Ca3Co4-xRhxO9 single crystals

    NASA Astrophysics Data System (ADS)

    Ikeda, Yusuke; Saito, Kengo; Okazaki, Ryuji

    2016-06-01

    We have examined an isovalent Rh substitution effect on the transport properties of the thermoelectric oxide Ca3Co4O9 using single-crystalline form. With increasing Rh content x, both the electrical resistivity and the Seebeck coefficient change systematically up to x = 0.6 for Ca3Co4-xRhxO9 samples. In the Fermi-liquid regime where the resistivity behaves as ρ = ρ 0 + A T 2 around 120 K, the A value decreases with increasing Rh content, indicating that the correlation effect is weakened by Rh 4d electrons with extended orbitals. We find that, in contrast to such a weak correlation effect observed in the resistivity of Rh-substituted samples, the low-temperature Seebeck coefficient is increased with increasing Rh content, which is explained with a possible enhancement of a pseudogap associated with the short-range order of spin density wave. In high-temperature range above room temperature, we show that the resistivity is largely suppressed by Rh substitution while the Seebeck coefficient becomes almost temperature-independent, leading to a significant improvement of the power factor in Rh-substituted samples. This result is also discussed in terms of the differences in the orbital size and the associated spin state between Co 3d and Rh 4d electrons.

  13. Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X

    PubMed Central

    Antonios, Gregory; Borgers, Henning; Richard, Bernhard C.; Brauß, Andreas; Meißner, Julius; Weggen, Sascha; Pena, Vladimir; Pillot, Thierry; Davies, Sarah L.; Bakrania, Preeti; Matthews, David; Brownlees, Janet; Bouter, Yvonne; Bayer, Thomas A.

    2015-01-01

    Full-length Aβ1-42 and Aβ1-40, N-truncated pyroglutamate Aβ3-42 and Aβ4-42 are major variants in the Alzheimer brain. Aβ4-42 has not been considered as a therapeutic target yet. We demonstrate that the antibody NT4X and its Fab fragment reacting with both the free N-terminus of Aβ4-x and pyroglutamate Aβ3-X mitigated neuron loss in Tg4-42 mice expressing Aβ4-42 and completely rescued spatial reference memory deficits after passive immunization. NT4X and its Fab fragment also rescued working memory deficits in wild type mice induced by intraventricular injection of Aβ4-42. NT4X reduced pyroglutamate Aβ3-x, Aβx-40 and Thioflavin-S positive plaque load after passive immunization of 5XFAD mice. Aβ1-x and Aβx-42 plaque deposits were unchanged. Importantly, for the first time, we demonstrate that passive immunization using the antibody NT4X is therapeutically beneficial in Alzheimer mouse models showing that N-truncated Aβ starting with position four in addition to pyroglutamate Aβ3-x is a relevant target to fight Alzheimer’s disease. PMID:26626428

  14. Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X.

    PubMed

    Antonios, Gregory; Borgers, Henning; Richard, Bernhard C; Brauß, Andreas; Meißner, Julius; Weggen, Sascha; Pena, Vladimir; Pillot, Thierry; Davies, Sarah L; Bakrania, Preeti; Matthews, David; Brownlees, Janet; Bouter, Yvonne; Bayer, Thomas A

    2015-12-02

    Full-length Aβ1-42 and Aβ1-40, N-truncated pyroglutamate Aβ3-42 and Aβ4-42 are major variants in the Alzheimer brain. Aβ4-42 has not been considered as a therapeutic target yet. We demonstrate that the antibody NT4X and its Fab fragment reacting with both the free N-terminus of Aβ4-x and pyroglutamate Aβ3-X mitigated neuron loss in Tg4-42 mice expressing Aβ4-42 and completely rescued spatial reference memory deficits after passive immunization. NT4X and its Fab fragment also rescued working memory deficits in wild type mice induced by intraventricular injection of Aβ4-42. NT4X reduced pyroglutamate Aβ3-x, Aβx-40 and Thioflavin-S positive plaque load after passive immunization of 5XFAD mice. Aβ1-x and Aβx-42 plaque deposits were unchanged. Importantly, for the first time, we demonstrate that passive immunization using the antibody NT4X is therapeutically beneficial in Alzheimer mouse models showing that N-truncated Aβ starting with position four in addition to pyroglutamate Aβ3-x is a relevant target to fight Alzheimer's disease.

  15. Union List Development: Control of the Serial Literature *

    PubMed Central

    Sawyers, Elizabeth J.

    1972-01-01

    The discussion covers the development of a national union list or finding tool for biomedical serial holdings and its integration into the National Serials Data Program, which is being developed under the auspices of the three National Libraries. Specific topics which are covered include: (1) Selection of the Union Catalog of Medical Periodicals (UCMP) as the basis for a biomedical list and the status of that activity; (2) discussion of the various methods of recording holdings; (3) status of the National Serials Data Program and a discussion of its relationship to the UCMP file; and (4) status of the Standard Serial Number and its relationship to other existing coding schemes for serial titles. PMID:5054307

  16. Conversion of the Minnesota Union List of Serials (MULS) To National Serials Data Program (NSDP) Requirements: A Proposal. Final Report.

    ERIC Educational Resources Information Center

    Grosch, Audrey N., Comp.

    The methodologies and costs of converting the Minnesota Union List of Serials (MULS) to the National Serials Data Program (NSDP) requirements are outlined in this document. The conversion is considered under four logical areas: 1) providing quantitative estimates of the amount of computer analysis and programing manpower required to perform a…

  17. Annexin proteins PP4 and PP4-X. Comparative characterization of biological activities of placental and recombinant proteins.

    PubMed Central

    Römisch, J; Grote, M; Weithmann, K U; Heimburger, N; Amann, E

    1990-01-01

    The human placental proteins PP4 and PP4-X, belonging to the annexin protein family, were expressed in Escherichia coli at high yield. The proteins were purified to homogeneity. The physicochemical parameters of the recombinant proteins were determined and compared with those of their natural placental counterparts. Except for a minor change in the pI, the proteins appeared to be indistinguishable by several criteria. Both recombinant PP4 and recombinant PP4-X were biologically active in a thromboplastin inhibition test and in a phospholipase A2 inhibition test. Images Fig. 2. Fig. 3. Fig. 4. PMID:2148260

  18. The Impact of International Standardization on the Rules of Entry for Serials

    ERIC Educational Resources Information Center

    Cannan, Judith Proctor

    1975-01-01

    The major provisions of the International Serials Data System and International Standard Bibliographic Description for Serials are presented and related to present rules of entry for serials as detailed in the Anglo-American Cataloging Rules. (Author)

  19. Passive serialization in a multitasking environment

    SciTech Connect

    Hennessey, J.P.; Osisek, D.L.; Seigh, J.W. II

    1989-02-28

    In a multiprocessing system having a control program in which data objects are shared among processes, this patent describes a method for serializing references to a data object by the processes so as to prevent invalid references to the data object by any process when an operation requiring exclusive access is performed by another process, comprising the steps of: permitting the processes to reference data objects on a shared access basis without obtaining a shared lock; monitoring a point of execution of the control program which is common to all processes in the system, which occurs regularly in the process' execution and across which no references to any data object can be maintained by any process, except references using locks; establishing a system reference point which occurs after each process in the system has passed the point of execution at least once since the last such system reference point; requesting an operation requiring exclusive access on a selected data object; preventing subsequent references by other processes to the selected data object; waiting until two of the system references points have occurred; and then performing the requested operation.

  20. Electrocoalescence based serial dilution of microfluidic droplets.

    PubMed

    Bhattacharjee, Biddut; Vanapalli, Siva A

    2014-07-01

    Dilution of microfluidic droplets where the concentration of a reagent is incrementally varied is a key operation in drop-based biological analysis. Here, we present an electrocoalescence based dilution scheme for droplets based on merging between moving and parked drops. We study the effects of fluidic and electrical parameters on the dilution process. Highly consistent coalescence and fine resolution in dilution factor are achieved with an AC signal as low as 10 V even though the electrodes are separated from the fluidic channel by insulator. We find that the amount of material exchange between the droplets per coalescence event is high for low capillary number. We also observe different types of coalescence depending on the flow and electrical parameters and discuss their influence on the rate of dilution. Overall, we find the key parameter governing the rate of dilution is the duration of coalescence between the moving and parked drop. The proposed design is simple incorporating the channel electrodes in the same layer as that of the fluidic channels. Our approach allows on-demand and controlled dilution of droplets and is simple enough to be useful for assays that require serial dilutions. The approach can also be useful for applications where there is a need to replace or wash fluid from stored drops.

  1. Switch for serial or parallel communication networks

    DOEpatents

    Crosette, Dario B.

    1994-01-01

    A communication switch apparatus and a method for use in a geographically extensive serial, parallel or hybrid communication network linking a multi-processor or parallel processing system has a very low software processing overhead in order to accommodate random burst of high density data. Associated with each processor is a communication switch. A data source and a data destination, a sensor suite or robot for example, may also be associated with a switch. The configuration of the switches in the network are coordinated through a master processor node and depends on the operational phase of the multi-processor network: data acquisition, data processing, and data exchange. The master processor node passes information on the state to be assumed by each switch to the processor node associated with the switch. The processor node then operates a series of multi-state switches internal to each communication switch. The communication switch does not parse and interpret communication protocol and message routing information. During a data acquisition phase, the communication switch couples sensors producing data to the processor node associated with the switch, to a downlink destination on the communications network, or to both. It also may couple an uplink data source to its processor node. During the data exchange phase, the switch couples its processor node or an uplink data source to a downlink destination (which may include a processor node or a robot), or couples an uplink source to its processor node and its processor node to a downlink destination.

  2. Task based synthesis of serial manipulators

    PubMed Central

    Patel, Sarosh; Sobh, Tarek

    2015-01-01

    Computing the optimal geometric structure of manipulators is one of the most intricate problems in contemporary robot kinematics. Robotic manipulators are designed and built to perform certain predetermined tasks. There is a very close relationship between the structure of the manipulator and its kinematic performance. It is therefore important to incorporate such task requirements during the design and synthesis of the robotic manipulators. Such task requirements and performance constraints can be specified in terms of the required end-effector positions, orientations and velocities along the task trajectory. In this work, we present a comprehensive method to develop the optimal geometric structure (DH parameters) of a non-redundant six degree of freedom serial manipulator from task descriptions. In this work we define, develop and test a methodology to design optimal manipulator configurations based on task descriptions. This methodology is devised to investigate all possible manipulator configurations that can satisfy the task performance requirements under imposed joint constraints. Out of all the possible structures, the structures that can reach all the task points with the required orientations are selected. Next, these candidate structures are tested to see whether they can attain end-effector velocities in arbitrary directions within the user defined joint constraints, so that they can deliver the best kinematic performance. Additionally least power consuming configurations are also identified. PMID:26257946

  3. Electrocoalescence based serial dilution of microfluidic droplets

    PubMed Central

    Bhattacharjee, Biddut; Vanapalli, Siva A.

    2014-01-01

    Dilution of microfluidic droplets where the concentration of a reagent is incrementally varied is a key operation in drop-based biological analysis. Here, we present an electrocoalescence based dilution scheme for droplets based on merging between moving and parked drops. We study the effects of fluidic and electrical parameters on the dilution process. Highly consistent coalescence and fine resolution in dilution factor are achieved with an AC signal as low as 10 V even though the electrodes are separated from the fluidic channel by insulator. We find that the amount of material exchange between the droplets per coalescence event is high for low capillary number. We also observe different types of coalescence depending on the flow and electrical parameters and discuss their influence on the rate of dilution. Overall, we find the key parameter governing the rate of dilution is the duration of coalescence between the moving and parked drop. The proposed design is simple incorporating the channel electrodes in the same layer as that of the fluidic channels. Our approach allows on-demand and controlled dilution of droplets and is simple enough to be useful for assays that require serial dilutions. The approach can also be useful for applications where there is a need to replace or wash fluid from stored drops. PMID:25379096

  4. Serial pattern learning during skilled walking.

    PubMed

    Wallace, Douglas G; Winter, Shawn S; Metz, Gerlinde A

    2012-03-01

    Rats possess a rich repertoire of sequentially organized, natural behaviors. It is possible that these natural behaviors may reflect implicit learning or relatively fixed movement patterns. The present study was conducted to determine whether factors known to influence implicit learning produce similar effects on the acquisition of skilled walking. Three groups of rats were trained to cross a horizontal ladder with rungs spaced according to three different levels of complexity. All training and testing were performed under dark conditions to assess the influence of non-visual modalities on skilled walking. Although all groups' performance improved throughout training, pattern complexity influenced the rate of improvement. In addition, performance during a probe session provided further evidence that each group encoded the rung spacing pattern experienced during training to create an internal representation. These observations demonstrate that the engram established during repetitive training represents either the temporal or spatial characteristics of rung spacing. These findings indicate that implicit learning contributes to the acquisition of natural sequential behaviors. Furthermore, serial pattern learning of rung spacing provides a novel task to determine sensory and motor contributions to the consolidation of skilled movement. PMID:22744781

  5. Serial femtosecond crystallography: the first five years

    PubMed Central

    Schlichting, Ilme

    2015-01-01

    Protein crystallography using synchrotron radiation sources has had a tremendous impact on biology, having yielded the structures of thousands of proteins and given detailed insight into their mechanisms. However, the technique is limited by the requirement for macroscopic crystals, which can be difficult to obtain, as well as by the often severe radiation damage caused in diffraction experiments, in particular when using tiny crystals. To slow radiation damage, data collection is typically performed at cryogenic temperatures. With the advent of free-electron lasers (FELs) capable of delivering extremely intense femtosecond X-ray pulses, this situation appears to be remedied, allowing the structure determination of undamaged macromolecules using either macroscopic or microscopic crystals. The latter are exposed to the FEL beam in random orientations and their diffraction data are collected at cryogenic or room temperature in a serial fashion, since each crystal is destroyed upon a single exposure. The new approaches required for crystal growth and delivery, and for diffraction data analysis, including de novo phasing, are reviewed. The opportunities and challenges of SFX are described, including applications such as time-resolved measurements and the analysis of radiation damage-prone systems. PMID:25866661

  6. Switch for serial or parallel communication networks

    DOEpatents

    Crosette, D.B.

    1994-07-19

    A communication switch apparatus and a method for use in a geographically extensive serial, parallel or hybrid communication network linking a multi-processor or parallel processing system has a very low software processing overhead in order to accommodate random burst of high density data. Associated with each processor is a communication switch. A data source and a data destination, a sensor suite or robot for example, may also be associated with a switch. The configuration of the switches in the network are coordinated through a master processor node and depends on the operational phase of the multi-processor network: data acquisition, data processing, and data exchange. The master processor node passes information on the state to be assumed by each switch to the processor node associated with the switch. The processor node then operates a series of multi-state switches internal to each communication switch. The communication switch does not parse and interpret communication protocol and message routing information. During a data acquisition phase, the communication switch couples sensors producing data to the processor node associated with the switch, to a downlink destination on the communications network, or to both. It also may couple an uplink data source to its processor node. During the data exchange phase, the switch couples its processor node or an uplink data source to a downlink destination (which may include a processor node or a robot), or couples an uplink source to its processor node and its processor node to a downlink destination. 9 figs.

  7. Infants' memory processing of a serial list: list length effects.

    PubMed

    Gulya, M; Sweeney, B; Rovee-Collier, C

    1999-05-01

    Six-month-olds, trained with a three-mobile serial list, exhibit a primacy effect 24 h later. In three experiments, we demonstrated that increasing list length impairs their memory for serial order. In all experiments, 6-month-olds were trained with a five-mobile list. In Experiment 1, infants failed to exhibit a primacy effect on a 24-h delayed recognition test, recognizing mobiles from all serial positions. In Experiment 2, infants did exhibit a primacy effect on a reactivation (priming) test, suggesting that they may originally have encoded serial-order information. Experiment 3 confirmed that serial-order information was represented in infants' training memory. After the reactivation treatment, infants were precued with one list member and tested for recognition of another. When precues specified valid order information, infants recognized test mobiles from the later serial positions. The memory dissociation for serial order on delayed recognition and reactivation tests adds to the growing evidence that young infants possess two functionally distinct memory systems.

  8. Charge-coupled-device parallel-to-serial converter

    NASA Technical Reports Server (NTRS)

    Tower, John R. (Inventor)

    1987-01-01

    A CCD parallel-to-serial converter comprising two successions of charge transfer stages, recurrently side-loaded with respective ones of parallelly supplied charge packets, then serially unloaded by time-interleaved respective shift register operations. The charge packets converted to time-division-multiplexed serial form are supplied to a shared electrometer, and the electrometer response is de-multiplexed. Preferably, shift register operations are carried forward concurrently at the same rate, but with the final charge transfer stages clocked in phases staggered in time.

  9. Association Analysis of Noncoding Variants in Neuroligins 3 and 4X Genes with Autism Spectrum Disorder in an Italian Cohort

    PubMed Central

    Landini, Martina; Merelli, Ivan; Raggi, M. Elisabetta; Galluccio, Nadia; Ciceri, Francesca; Bonfanti, Arianna; Camposeo, Serena; Massagli, Angelo; Villa, Laura; Salvi, Erika; Cusi, Daniele; Molteni, Massimo; Milanesi, Luciano; Marabotti, Anna; Mezzelani, Alessandra

    2016-01-01

    Since involved in synaptic transmission and located on X-chromosome, neuroligins 3 and 4X have been studied as good positional and functional candidate genes for autism spectrum disorder pathogenesis, although contradictory results have been reported. Here, we performed a case-control study to assess the association between noncoding genetic variants in NLGN3 and NLGN4X genes and autism, in an Italian cohort of 202 autistic children analyzed by high-resolution melting. The results were first compared with data from 379 European healthy controls (1000 Genomes Project) and then with those from 1061 Italian controls genotyped by Illumina single nucleotide polymorphism (SNP) array 1M-duo. Statistical evaluations were performed using Plink v1.07, with the Omnibus multiple loci approach. According to both the European and the Italian control groups, a 6-marker haplotype on NLGN4X (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, p-value = 2.58 × 10−6 for the European controls; odds ratio = 2.42, p-value = 6.33 × 10−3 for the Italian controls). Furthermore, several haplotype blocks at 5-, 4-, 3-, and 2-, including the first 5, 4, 3, and 2 SNPs, respectively, showed a similar association with autism. We provide evidence that noncoding polymorphisms on NLGN4X may be associated to autism, suggesting the key role of NLGN4X in autism pathophysiology and in its male prevalence. PMID:27782075

  10. Automatic registration of serial mammary gland sections

    SciTech Connect

    Arganda-Carreras, Ignacio; Fernandez-Gonzalez, Rodrigo; Ortiz-de-Solorzano, Carlos

    2004-04-13

    We present two new methods for automatic registration of microscope images of consecutive tissue sections. They represent two possibilities for the first step in the 3-D reconstruction of histological structures from serially sectioned tissue blocks. The goal is to accurately align the sections in order to place every relevant shape contained in each image in front of its corresponding shape in the following section before detecting the structures of interest and rendering them in 3D. This is accomplished by finding the best rigid body transformation (translation and rotation) of the image being registered by maximizing a matching function based on the image content correlation. The first method makes use of the entire image information, whereas the second one uses only the information located at specific sites, as determined by the segmentation of the most relevant tissue structures. To reduce computing time, we use a multiresolution pyramidal approach that reaches the best registration transformation in increasing resolution steps. In each step, a subsampled version of the images is used. Both methods rely on a binary image which is a thresholded version of the Sobel gradients of the image (first method) or a set of boundaries manually or automatically obtained that define important histological structures of the sections. Then distance-transform of the binary image is computed. A proximity function is then calculated between the distance image of the image being registered and that of the reference image. The transformation providing a maximum of the proximity function is then used as the starting point of the following step. This is iterated until the registration error lies below a minimum value.

  11. Serial Position and Isolation Effects in a Classroom Lecture Simulation

    ERIC Educational Resources Information Center

    Holen, Michael C.; Oaster, Thomas R.

    1976-01-01

    Provides evidence of the existence of serial position and isolation effects in a classroom lecture simulation involving extended meaningful discourse. Isolating an item facilitated learning of that item. (Author/DEP)

  12. An isolation effect in serial memory for spatial information.

    PubMed

    Guérard, Katherine; Hughes, Robert W; Tremblay, Sébastien

    2008-05-01

    This paper reports the first demonstration of an isolation effect or von Restorff effect (von Restorff, 1933) in the context of a spatial-memory task: Short-term serial recall was enhanced for both the location and the serial position of one red dot presented amongst a sequence of otherwise black dots. When the serial position of the isolate was fixed, the spatial isolation effect only emerged when participants received a control block of trials before the block of isolation trials (Experiment 1). However, when the serial position of the isolate was varied across isolation trials, an isolation effect was still produced regardless of condition order (Experiment 2). It is suggested that both temporal grouping strategies and greater item-specific processing may have contributed to the enhanced retention of the isolate.

  13. Pauses and durations exhibit a serial position effect.

    PubMed

    Haberlandt, Karl; Lawrence, Holly; Krohn, Talia; Bower, Katherine; Thomas, J Graham

    2005-02-01

    This article reports evidence of two kinds of serial position effects in immediate serial recall: One involves interresponse pauses, and the other response durations. In forward and backward recall, responding was faster at initial and final positions than at center positions, exhibitinga bow-shaped function relative to serial position. These data were obtained in a spoken recall study in which ungrouped lists of four to six words and postcuing of recall direction were used. The pause pattern is consistent with several models of serial memory, including a distinctiveness model (Brown, Neath, & Chater, 2002) and a version of the ACT-R model augmented with a spontaneous grouping strategy (Maybery, Parmentier, & Jones, 2002). The duration pattern suggests that response articulation depends on the processing context, rather than being modular.

  14. Within-List Serial Position Effects in Free Recall

    ERIC Educational Resources Information Center

    Gorfein, David S.; And Others

    1976-01-01

    The present article reports six studies that both extend the range of conditions that produce within-list serial position effects and attempt to unravel three possible theoretical explanations for these functions. (Editor)

  15. Fast Grasp Contact Computation for a Serial Robot

    NASA Technical Reports Server (NTRS)

    Shi, Jianying (Inventor); Hargrave, Brian (Inventor); Diftler, Myron A. (Inventor)

    2015-01-01

    A system includes a controller and a serial robot having links that are interconnected by a joint, wherein the robot can grasp a three-dimensional (3D) object in response to a commanded grasp pose. The controller receives input information, including the commanded grasp pose, a first set of information describing the kinematics of the robot, and a second set of information describing the position of the object to be grasped. The controller also calculates, in a two-dimensional (2D) plane, a set of contact points between the serial robot and a surface of the 3D object needed for the serial robot to achieve the commanded grasp pose. A required joint angle is then calculated in the 2D plane between the pair of links using the set of contact points. A control action is then executed with respect to the motion of the serial robot using the required joint angle.

  16. Effect of serial extraction alone on crowding: spontaneous changes in dentition after serial extraction.

    PubMed

    Yoshihara, T; Matsumoto, Y; Suzuki, J; Sato, N; Oguchi, H

    2000-12-01

    We examined changes in dentition after serial extraction in subjects who wore no appliances to determine the relationships between changes in dentition and improvement in dental crowding. Mandibular dental casts and lateral cephalograms from 31 subjects who had undergone serial extraction without orthodontic treatment were analyzed at 3 stages: before extraction of the deciduous canines (T1), after extraction of first premolars (T2), and at the end of the observation period (T3). Although movements of the first molar cusp and apex from T2 to T3 were significantly greater than from T1 to T2, movements of the incisor cusp and apex from T1 to T2 were significantly greater than from T2 to T3. The first molar tipped mesially from T1 to T2 but tipped distally from T2 to T3. The distal tipping of the incisor from T1 to T2 was significantly greater than from T2 to T3. These results suggest that the main changes in dentition from T1 to T2 are different from those from T2 to T3. The correlations between the annual change in the canine movement or tipping from T2 to T3 and the annual change in the irregularity index at the same time were significant. These results suggest that the canine movement or tipping contributed to the correction of the anterior crowding from T2 to T3.

  17. Butterfly eyespot serial homology: enter the Hox genes.

    PubMed

    Hombría, James Castelli-Gair

    2011-01-01

    Hox genes modify serial homology patterns in many organisms, exemplified in vertebrates by modification of the axial skeleton and in arthropods by diversification of the body segments. Butterfly wing eyespots also appear in a serial homologous pattern that, in certain species, is subject to local modification. A paper in EvoDevo reports the Hox gene Antp is the earliest known gene to have eyespot-specific expression; however, not all Lepidoptera express Antp in eyespots, suggesting some developmental flexibility. PMID:21527048

  18. [A serial killer as exemplified by T. R. Bundy].

    PubMed

    Gałeska-Sliwka, Anita

    2008-01-01

    The question of serial homicides and their perpetrators poses a considerable problem of both a definitional and practical nature. T R. Bundy is the first perpetrator who was officially termed a "serial killer". Since that time, this concept has been commonly used and sometimes even overused, e.g. in reference to mass murderers. However, the definitions established for Bundy's case have been preserved and continue to be used in practice.

  19. Butterfly eyespot serial homology: enter the Hox genes.

    PubMed

    Hombría, James Castelli-Gair

    2011-01-01

    Hox genes modify serial homology patterns in many organisms, exemplified in vertebrates by modification of the axial skeleton and in arthropods by diversification of the body segments. Butterfly wing eyespots also appear in a serial homologous pattern that, in certain species, is subject to local modification. A paper in EvoDevo reports the Hox gene Antp is the earliest known gene to have eyespot-specific expression; however, not all Lepidoptera express Antp in eyespots, suggesting some developmental flexibility.

  20. Serial reversal learning of position discrimination in developing rats.

    PubMed

    Watson, Deborah J; Sullivan, Jesse R; Frank, Julie G; Stanton, Mark E

    2006-01-01

    The current study established a procedure to evaluate the capability of rats on postnatal days (PND) 21, 26, and 30 to perform a spatial serial reversal task using a T-maze. Training consisted of an acquisition session followed by a series of six reversal sessions. To examine the role of proactive interference in the serial reversal effect, the point of reversal was manipulated so that it occurred at the start of each session (between-sessions) or the midpoint of each session (within-sessions). Performance was initially impaired during the first reversal but improved dramatically across the series. Reversal between-sessions enhanced this serial reversal effect in comparison to reversal within-sessions. Experiment 1 showed that rats of all ages learned the between-sessions serial reversal task at a comparable rate. However, on the within-sessions task, PND21 rats were impaired relative to the PND26 and 30 rats, which did not differ. Experiment 2 revealed that the addition of a tactile cue that is correlated with each phase of reversal eliminated age and task differences in serial reversal performance. These findings suggest that higher-order cognitive processes underlying serial reversal are present during the weanling period, but there is some improvement with age under conditions involving high memory interference and/or difficulty in detecting the transition between reversal phases.

  1. Three more semantic serial position functions and a SIMPLE explanation.

    PubMed

    Kelley, Matthew R; Neath, Ian; Surprenant, Aimée M

    2013-05-01

    There are innumerable demonstrations of serial position functions-with characteristic primacy and recency effects-in episodic tasks, but there are only a handful of such demonstrations in semantic memory tasks, and those demonstrations have used only two types of stimuli. Here, we provide three more examples of serial position functions when recalling from semantic memory. Participants were asked to reconstruct the order of (1) two cartoon theme song lyrics, (2) the seven Harry Potter books, and (3) two sets of movies, and all three demonstrations yielded conventional-looking serial position functions with primacy and recency effects. The data were well-fit by SIMPLE, a local distinctiveness model of memory that was originally designed to account for serial position effects in short- and long-term episodic memory. According to SIMPLE, serial position functions in both episodic and semantic memory tasks arise from the same type of processing: Items that are more separated from their close neighbors in psychological space at the time of recall will be better remembered. We argue that currently available evidence suggests that serial position functions observed when recalling items that are presumably in semantic memory arise because of the same processes as those observed when recalling items that are presumably in episodic memory.

  2. Development of serial processing in reading and rapid naming.

    PubMed

    Protopapas, Athanassios; Altani, Angeliki; Georgiou, George K

    2013-12-01

    Serial rapid automatized naming (RAN) is more strongly related to reading fluency than naming of isolated words, suggesting that the implementation of serial processing may underlie the RAN-reading relationship. In this study, 107 Greek children from Grade 2 and 107 from Grade 6 were tested with discrete and serial naming of digits, objects, and words in 50-item arrays. The correlation between discrete and serial word reading was very high in Grade 2 but only moderate in Grade 6. In confirmatory factor analysis, a reading-naming latent structure fit the Grade 2 data best; in contrast, a serial-discrete structure fit the Grade 6 data. Thus, the superficial longitudinal stability of RAN-reading correlations belies vastly different patterns of interrelations, indicative of changes in the developing cognitive processes underlying both naming and reading. Word fluency tasks in Grade 2 are apparently accomplished largely as a series of isolated individual word naming trials even though multiple individual letters in each word may be processed in parallel. In contrast, specifically serial procedures are applied in Grade 6, presumably via simultaneous processing of multiple individual words at successive levels. It is proposed that this feat requires endogenous control of cognitive cascades.

  3. Serial CSTR digester configuration for improving biogas production from manure.

    PubMed

    Boe, Kanokwan; Angelidaki, Irini

    2009-01-01

    A new configuration of manure digesters for improving biogas production has been investigated in laboratory scale. A single thermophilic continuous-flow stirred tank reactor (CSTR) operated with a hydraulic retention time (HRT) of 15 days was compared to a serial CSTR configuration with volume distribution ratio of 80/20 and 90/10, and total HRT of 15 days. The results showed that the serial CSTR could obtain 11% higher biogas yield compared to the single CSTR. The increased biogas yield in the serial CSTR was mainly from the second reactor, which accounted for 16% and 12% of total biogas yield in the 90/10 and 80/20 configuration, respectively. VFA concentration in the serial CSTR was high in the first reactor but very low in the second reactor. The results from organic pulse load test showed that the second reactor in serial CSTR helped utilizing VFA produced from overloading in the first reactor, which improved the effluent quality and conversion efficiency of the serial CSTR.

  4. Development of serial processing in reading and rapid naming.

    PubMed

    Protopapas, Athanassios; Altani, Angeliki; Georgiou, George K

    2013-12-01

    Serial rapid automatized naming (RAN) is more strongly related to reading fluency than naming of isolated words, suggesting that the implementation of serial processing may underlie the RAN-reading relationship. In this study, 107 Greek children from Grade 2 and 107 from Grade 6 were tested with discrete and serial naming of digits, objects, and words in 50-item arrays. The correlation between discrete and serial word reading was very high in Grade 2 but only moderate in Grade 6. In confirmatory factor analysis, a reading-naming latent structure fit the Grade 2 data best; in contrast, a serial-discrete structure fit the Grade 6 data. Thus, the superficial longitudinal stability of RAN-reading correlations belies vastly different patterns of interrelations, indicative of changes in the developing cognitive processes underlying both naming and reading. Word fluency tasks in Grade 2 are apparently accomplished largely as a series of isolated individual word naming trials even though multiple individual letters in each word may be processed in parallel. In contrast, specifically serial procedures are applied in Grade 6, presumably via simultaneous processing of multiple individual words at successive levels. It is proposed that this feat requires endogenous control of cognitive cascades. PMID:24077466

  5. Three more semantic serial position functions and a SIMPLE explanation.

    PubMed

    Kelley, Matthew R; Neath, Ian; Surprenant, Aimée M

    2013-05-01

    There are innumerable demonstrations of serial position functions-with characteristic primacy and recency effects-in episodic tasks, but there are only a handful of such demonstrations in semantic memory tasks, and those demonstrations have used only two types of stimuli. Here, we provide three more examples of serial position functions when recalling from semantic memory. Participants were asked to reconstruct the order of (1) two cartoon theme song lyrics, (2) the seven Harry Potter books, and (3) two sets of movies, and all three demonstrations yielded conventional-looking serial position functions with primacy and recency effects. The data were well-fit by SIMPLE, a local distinctiveness model of memory that was originally designed to account for serial position effects in short- and long-term episodic memory. According to SIMPLE, serial position functions in both episodic and semantic memory tasks arise from the same type of processing: Items that are more separated from their close neighbors in psychological space at the time of recall will be better remembered. We argue that currently available evidence suggests that serial position functions observed when recalling items that are presumably in semantic memory arise because of the same processes as those observed when recalling items that are presumably in episodic memory. PMID:23263860

  6. The Assessment of Experimental Methods of Serial Number Restoration

    NASA Astrophysics Data System (ADS)

    Argo, Mackenzie

    Serial number restoration is a common and successful process of revealing obliterated serial numbers on firearms. In a crime laboratory setting, obliterated serial numbers are commonly processed in order to tie a person to a crime scene or provide an investigative lead for officers. Currently serial numbers are restored using a chemical etchant method that can eat away at the metal on the firearm even after the examination is complete. It can also take several hours to complete and only provide an examiner with a partial number. There are other nondestructive options however little to no literature is available. The purpose of this study is to discover new methods for nondestructive serial number restoration and to compare them to the traditional chemical method used. Metal bars of premeasured obliteration depths and different compositions were examined using three proposed experimental methods: near infrared imaging, cold frost, and scanning acoustic microscopy. Results did not indicate significant difference in the median number of visible digits recovered for each of the three proposed methods compared to the traditional chemical method. There were significant results in the median number of composition utilized and depth of obliteration. This indicates that different firearm compositions and depth of obliteration has an effect on serial number restoration.

  7. 75 FR 56916 - Viruses, Serums, Toxins, and Analogous Products; Expiration Date Required for Serials and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... serials or subserials are released for marketing before the first production serials reach the end of... of production serials beginning on the day of filling into final containers or the date final... filed Outline of Production; and Require the periodic testing of serials or subserials to monitor...

  8. Analysis of assembly serial number usage in domestic light-water reactors

    SciTech Connect

    Reich, W.J. ); Moore, R.S. )

    1991-05-01

    Domestic light-water reactor (LWR) fuel assemblies are identified by a serial number that is placed on each assembly. These serial numbers are used as identifiers throughout the life of the fuel. The uniqueness of assembly serial numbers is important in determining their effectiveness as unambiguous identifiers. The purpose of this study is to determine what serial numbering schemes are used, the effectiveness of these schemes, and to quantify how many duplicate serial numbers occur on domestic LWR fuel assemblies. The serial numbering scheme adopted by the American National Standards Institute (ANSI) ensures uniqueness of assembly serial numbers. The latest numbering scheme adopted by General Electric (GE), was also found to be unique. Analysis of 70,971 fuel assembly serial numbers from permanently discharged fuel identified 11,948 serial number duplicates. Three duplicate serial numbers were found when analysis focused on duplication within the individual fuel inventory at each reactor site, but these were traced back to data entry errors and will be corrected by the Energy Information Administration (EIA). There were also three instances where the serial numbers used to identify assemblies used for hot cell studies differed from the serial numbers reported to the EIA. It is recommended that fuel fabricators and utilities adhere to the ANSI serial numbering scheme to ensure serial number uniqueness. In addition, organizations collecting serial number information, should request that all known serial numbers physically attached or associated with each assembly be reported and identified by the corresponding number scheme. 10 refs., 5 tabs.

  9. Observation of the suppression of the flux of cosmic rays above 4x10^19eV

    SciTech Connect

    Abraham, J.; Abreu, P.; Aglietta, M.; Aguirre, C.; Allard, D.; Allekotte, I.; Allen, J.; Allison, P.; Alvarez-Muniz, J.; Ambrosio, M.; Anchordoqui, L.; /Wisconsin U., Milwaukee /Northeastern U. /Lisbon, IST /Lisbon, LIFEP

    2008-06-01

    The energy spectrum of cosmic rays above 2.5 x 10{sup 18} eV, derived from 20,000 events recorded at the Pierre Auger Observatory, is described. The spectral index {gamma} of the particle flux, J {proportional_to} E{sup {gamma}}, at energies between 4 x 10{sup 18} eV and 4 x 10{sup 19} eV is 2.69 {+-} 0.02(stat){+-}0.06(syst), steepening to 4.2 {+-} 0.4(stat){+-}0.06(syst) at higher energies. The hypothesis of a single power law is rejected with a significance greater than 6 standard deviations. The data are consistent with the prediction by Greisen and by Zatsepin and Kuzmin.

  10. Observation of the suppression of the flux of cosmic rays above 4 x 10 (19) eV.

    PubMed

    Abraham, J; Abreu, P; Aglietta, M; Aguirre, C; Allard, D; Allekotte, I; Allen, J; Allison, P; Alvarez-Muñiz, J; Ambrosio, M; Anchordoqui, L; Andringa, S; Anzalone, A; Aramo, C; Argirò, S; Arisaka, K; Armengaud, E; Arneodo, F; Arqueros, F; Asch, T; Asorey, H; Assis, P; Atulugama, B S; Aublin, J; Ave, M; Avila, G; Bäcker, T; Badagnani, D; Barbosa, A F; Barnhill, D; Barroso, S L C; Baughman, B; Bauleo, P; Beatty, J J; Beau, T; Becker, B R; Becker, K H; Bellido, J A; Benzvi, S; Berat, C; Bergmann, T; Bernardini, P; Bertou, X; Biermann, P L; Billoir, P; Blanch-Bigas, O; Blanco, F; Blasi, P; Bleve, C; Blümer, H; Bohácová, M; Bonifazi, C; Bonino, R; Brack, J; Brogueira, P; Brown, W C; Buchholz, P; Bueno, A; Burton, R E; Busca, N G; Caballero-Mora, K S; Cai, B; Camin, D V; Caramete, L; Caruso, R; Carvalho, W; Castellina, A; Catalano, O; Cataldi, G; Cazon, L; Cester, R; Chauvin, J; Chiavassa, A; Chinellato, J A; Chou, A; Chudoba, J; Chye, J; Clark, P D J; Clay, R W; Colombo, E; Conceição, R; Connolly, B; Contreras, F; Coppens, J; Cordier, A; Cotti, U; Coutu, S; Covault, C E; Creusot, A; Criss, A; Cronin, J; Curutiu, A; Dagoret-Campagne, S; Daumiller, K; Dawson, B R; de Almeida, R M; De Donato, C; de Jong, S J; De La Vega, G; Junior, W J M de Mello; Neto, J R T de Mello; De Mitri, I; de Souza, V; Del Peral, L; Deligny, O; Della Selva, A; Fratte, C Delle; Dembinski, H; Di Giulio, C; Diaz, J C; Diep, P N; Dobrigkeit, C; D'Olivo, J C; Dong, P N; Dornic, D; Dorofeev, A; Dos Anjos, J C; Dova, M T; D'Urso, D; Dutan, I; Duvernois, M A; Engel, R; Epele, L; Erdmann, M; Escobar, C O; Etchegoyen, A; Luis, P Facal San; Falcke, H; Farrar, G; Fauth, A C; Fazzini, N; Ferrer, F; Ferrero, A; Fick, B; Filevich, A; Filipcic, A; Fleck, I; Fracchiolla, C E; Fulgione, W; García, B; Gámez, D García; Garcia-Pinto, D; Garrido, X; Geenen, H; Gelmini, G; Gemmeke, H; Ghia, P L; Giller, M; Glass, H; Gold, M S; Golup, G; Albarracin, F Gomez; Berisso, M Gómez; Gonçalves, P; do Amaral, M Gonçalves; Gonzalez, D; Gonzalez, J G; González, M; Góra, D; Gorgi, A; Gouffon, P; Grassi, V; Grillo, A F; Grunfeld, C; Guardincerri, Y; Guarino, F; Guedes, G P; Gutiérrez, J; Hague, J D; Halenka, V; Hamilton, J C; Hansen, P; Harari, D; Harmsma, S; Harton, J L; Haungs, A; Hauschildt, T; Healy, M D; Hebbeker, T; Hebrero, G; Heck, D; Hojvat, C; Holmes, V C; Homola, P; Hörandel, J R; Horneffer, A; Hrabovský, M; Huege, T; Hussain, M; Iarlori, M; Insolia, A; Ionita, F; Italiano, A; Kaducak, M; Kampert, K H; Karova, T; Kasper, P; Kégl, B; Keilhauer, B; Kemp, E; Kieckhafer, R M; Klages, H O; Kleifges, M; Kleinfeller, J; Knapik, R; Knapp, J; Koang, D-H; Krieger, A; Krömer, O; Kuempel, D; Kunka, N; Kusenko, A; La Rosa, G; Lachaud, C; Lago, B L; Lebrun, D; Lebrun, P; Lee, J; de Oliveira, M A Leigui; Letessier-Selvon, A; Leuthold, M; Lhenry-Yvon, I; López, R; Agüera, A Lopez; Bahilo, J Lozano; Lucero, A; García, R Luna; Maccarone, M C; Macolino, C; Maldera, S; Mancarella, G; Manceñido, M E; Mandat, D; Mantsch, P; Mariazzi, A G; Maris, I C; Falcon, H R Marquez; Martello, D; Martínez, J; Bravo, O Martínez; Mathes, H J; Matthews, J; Matthews, J A J; Matthiae, G; Maurizio, D; Mazur, P O; McCauley, T; McEwen, M; McNeil, R R; Medina, M C; Medina-Tanco, G; Melo, D; Menichetti, E; Menschikov, A; Meurer, C; Meyhandan, R; Micheletti, M I; Miele, G; Miller, W; Mollerach, S; Monasor, M; Ragaigne, D Monnier; Montanet, F; Morales, B; Morello, C; Moreno, J C; Morris, C; Mostafá, M; Muller, M A; Mussa, R; Navarra, G; Navarro, J L; Navas, S; Necesal, P; Nellen, L; Newman-Holmes, C; Newton, D; Nhung, P T; Nierstenhoefer, N; Nitz, D; Nosek, D; Nozka, L; Oehlschläger, J; Ohnuki, T; Olinto, A; Olmos-Gilbaja, V M; Ortiz, M; Ortolani, F; Ostapchenko, S; Otero, L; Pacheco, N; Selmi-Dei, D Pakk; Palatka, M; Pallotta, J; Parente, G; Parizot, E; Parlati, S; Pastor, S; Patel, M; Paul, T; Pavlidou, V; Payet, K; Pech, M; Pekala, J; Pelayo, R; Pepe, I M; Perrone, L; Pesce, R; Petrera, S; Petrinca, P; Petrov, Y; Pichel, A; Piegaia, R; Pierog, T; Pimenta, M; Pinto, T; Pirronello, V; Pisanti, O; Platino, M; Pochon, J; Privitera, P; Prouza, M; Quel, E J; Rautenberg, J; Redondo, A; Reucroft, S; Revenu, B; Rezende, F A S; Ridky, J; Riggi, S; Risse, M; Rivière, C; Rizi, V; Roberts, M; Robledo, C; Rodriguez, G; Martino, J Rodriguez; Rojo, J Rodriguez; Rodriguez-Cabo, I; Rodríguez-Frías, M D; Ros, G; Rosado, J; Roth, M; Rouillé-d'Orfeuil, B; Roulet, E; Rovero, A C; Salamida, F; Salazar, H; Salina, G; Sánchez, F; Santander, M; Santo, C E; Santos, E M; Sarazin, F; Sarkar, S; Sato, R; Scherini, V; Schieler, H; Schmidt, A; Schmidt, F; Schmidt, T; Scholten, O; Schovánek, P; Schroeder, F; Schulte, S; Schüssler, F; Sciutto, S J; Scuderi, M; Segreto, A; Semikoz, D; Settimo, M; Shellard, R C; Sidelnik, I; Siffert, B B; Sigl, G; Grande, N Smetniansky De; Smiałkowski, A; Smída, R; Smith, A G K; Smith, B E; Snow, G R; Sokolsky, P; Sommers, P; Sorokin, J; Spinka, H; Squartini, R; Strazzeri, E; Stutz, A; Suarez, F; Suomijärvi, T; Supanitsky, A D; Sutherland, M S; Swain, J; Szadkowski, Z; Takahashi, J; Tamashiro, A; Tamburro, A; Tarutina, T; Taşcău, O; Tcaciuc, R; Thao, N T; Thomas, D; Ticona, R; Tiffenberg, J; Timmermans, C; Tkaczyk, W; Peixoto, C J Todero; Tomé, B; Tonachini, A; Torres, I; Travnicek, P; Tripathi, A; Tristram, G; Tscherniakhovski, D; Tuci, V; Tueros, M; Tunnicliffe, V; Ulrich, R; Unger, M; Urban, M; Galicia, J F Valdés; Valiño, I; Valore, L; van den Berg, A M; van Elewyck, V; Vázquez, R A; Veberic, D; Veiga, A; Velarde, A; Venters, T; Verzi, V; Videla, M; Villaseñor, L; Vorobiov, S; Voyvodic, L; Wahlberg, H; Wahrlich, P; Wainberg, O; Walker, P; Warner, D; Watson, A A; Westerhoff, S; Wieczorek, G; Wiencke, L; Wilczyńska, B; Wilczyński, H; Wileman, C; Winnick, M G; Wu, H; Wundheiler, B; Yamamoto, T; Younk, P; Zas, E; Zavrtanik, D; Zavrtanik, M; Zaw, I; Zepeda, A; Ziolkowski, M

    2008-08-01

    The energy spectrum of cosmic rays above 2.5 x 10;{18} eV, derived from 20,000 events recorded at the Pierre Auger Observatory, is described. The spectral index gamma of the particle flux, J proportional, variantE;{-gamma}, at energies between 4 x 10;{18} eV and 4 x 10;{19} eV is 2.69+/-0.02(stat)+/-0.06(syst), steepening to 4.2+/-0.4(stat)+/-0.06(syst) at higher energies. The hypothesis of a single power law is rejected with a significance greater than 6 standard deviations. The data are consistent with the prediction by Greisen and by Zatsepin and Kuz'min.

  11. Effects of Tb3+ concentration on the La2Sr3(BO3)4: X% Tb3+ polycrystalline nanophosphor

    NASA Astrophysics Data System (ADS)

    Mlotswa, D. V.; Madihlaba, R. M.; Koao, L. F.; Onani, M. O.; Dejene, F. B.

    2016-01-01

    A new green phosphor, La2Sr3(BO3)4): x% Tb3+ was fabricated by solution-combustion method using urea as a fuel and ammonium nitrate as an oxidizer. The phosphor was characterised using Fourier transform infrared spectroscopy (FTIR), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Energy dispersive spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and photoluminescence spectroscopy (PL. The results exhibit that La2Sr3(BO3)4): x% Tb3+ phosphor has the strongest excitation at 209 nm with a full-width at half-maximum (FWHM) of 20 nm, and can emit bright green light at 545 nm under 209 nm excitation. The optimum concentration for Tb3+ in La2Sr3(BO3)4): x% Tb3+ is 0.033 mol%. The prominent green luminescence was due to the 5D4-7F5 transition of Tb3+ ion. Herein, the green phosphors are promising good candidates employed in tri-color lamps.

  12. Photoluminescence behavior of ZnGa 2O 4- xSe x:Mn 2+ thin film phosphors

    NASA Astrophysics Data System (ADS)

    Yi, S. S.; Bae, J. S.; Shim, K. S.; Jeong, J. H.; Park, H. L.; Holloway, P. H.

    2003-11-01

    Mn-doped ZnGa 2O 4- xSe x thin film phosphors have been grown using pulsed-laser ablation at the various growth conditions. Structural characterization was carried out on a series of ZnGa 2O 4- xSe x:Mn 2+ films grown on MgO(1 0 0) substrates using Zn-rich ceramic targets at various substrate temperatures and oxygen pressures. The films grown under different conditions not only have different crystallinity and surface morphology but also different Zn/Ga composition ratio. The luminescent results indicated that MgO (1 0 0) is one of the most promised substrates for the growth of high quality ZnGa 2O 4- xSe x:Mn 2+ films and the luminescent brightness is sensitive to the substrate temperature and oxygen pressure. In particular, the incorporation of Se into ZnGa 2O 4:Mn 2+ lattice induced a remarkable increase of photoluminescence (PL). The highest green emission intensity was observed with ZnGa 2O 3.925Se 0.075:Mn 2+ films, whose brightness was increased by a factor of 3.1 in comparison with that of ZnGa 2O 4:Mn 2+ films. This phosphor is promising for applications in flat panel displays.

  13. Hardware Implementation of Serially Concatenated PPM Decoder

    NASA Technical Reports Server (NTRS)

    Moision, Bruce; Hamkins, Jon; Barsoum, Maged; Cheng, Michael; Nakashima, Michael

    2009-01-01

    A prototype decoder for a serially concatenated pulse position modulation (SCPPM) code has been implemented in a field-programmable gate array (FPGA). At the time of this reporting, this is the first known hardware SCPPM decoder. The SCPPM coding scheme, conceived for free-space optical communications with both deep-space and terrestrial applications in mind, is an improvement of several dB over the conventional Reed-Solomon PPM scheme. The design of the FPGA SCPPM decoder is based on a turbo decoding algorithm that requires relatively low computational complexity while delivering error-rate performance within approximately 1 dB of channel capacity. The SCPPM encoder consists of an outer convolutional encoder, an interleaver, an accumulator, and an inner modulation encoder (more precisely, a mapping of bits to PPM symbols). Each code is describable by a trellis (a finite directed graph). The SCPPM decoder consists of an inner soft-in-soft-out (SISO) module, a de-interleaver, an outer SISO module, and an interleaver connected in a loop (see figure). Each SISO module applies the Bahl-Cocke-Jelinek-Raviv (BCJR) algorithm to compute a-posteriori bit log-likelihood ratios (LLRs) from apriori LLRs by traversing the code trellis in forward and backward directions. The SISO modules iteratively refine the LLRs by passing the estimates between one another much like the working of a turbine engine. Extrinsic information (the difference between the a-posteriori and a-priori LLRs) is exchanged rather than the a-posteriori LLRs to minimize undesired feedback. All computations are performed in the logarithmic domain, wherein multiplications are translated into additions, thereby reducing complexity and sensitivity to fixed-point implementation roundoff errors. To lower the required memory for storing channel likelihood data and the amounts of data transfer between the decoder and the receiver, one can discard the majority of channel likelihoods, using only the remainder in

  14. [Transcriptomes for serial analysis of gene expression].

    PubMed

    Marti, Jacques; Piquemal, David; Manchon, Laurent; Commes, Thérèse

    2002-01-01

    The availability of the sequences for whole genomes is changing our understanding of cell biology. Functional genomics refers to the comprehensive analysis, at the protein level (proteome) and at the mRNA level (transcriptome) of all events associated with the expression of whole sets of genes. New methods have been developed for transcriptome analysis. Serial Analysis of Gene Expression (SAGE) is based on the massive sequential analysis of short cDNA sequence tags. Each tag is derived from a defined position within a transcript. Its size (14 bp) is sufficient to identify the corresponding gene and the number of times each tag is observed provides an accurate measurement of its expression level. Since tag populations can be widely amplified without altering their relative proportions, SAGE may be performed with minute amounts of biological extract. Dealing with the mass of data generated by SAGE necessitates computer analysis. A software is required to automatically detect and count tags from sequence files. Criterias allowing to assess the quality of experimental data can be included at this stage. To identify the corresponding genes, a database is created registering all virtual tags susceptible to be observed, based on the present status of the genome knowledge. By using currently available database functions, it is easy to match experimental and virtual tags, thus generating a new database registering identified tags, together with their expression levels. As an open system, SAGE is able to reveal new, yet unknown, transcripts. Their identification will become increasingly easier with the progress of genome annotation. However, their direct characterization can be attempted, since tag information may be sufficient to design primers allowing to extend unknown sequences. A major advantage of SAGE is that, by measuring expression levels without reference to an arbitrary standard, data are definitively acquired and cumulative. All publicly available data can thus

  15. Positional and temporal clustering in serial order memory.

    PubMed

    Solway, Alec; Murdock, Bennet B; Kahana, Michael J

    2012-02-01

    The well-known finding that responses in serial recall tend to be clustered around the position of the target item has bolstered positional-coding theories of serial order memory. In the present study, we show that this effect is confounded with another well-known finding--that responses in serial recall tend to also be clustered around the position of the prior recall (temporal clustering). The confound can be alleviated by conditioning each analysis on the positional accuracy of the previously recalled item. The revised analyses show that temporal clustering is much more prevalent in serial recall than is positional clustering. A simple associative chaining model with asymmetric neighboring, remote associations, and a primacy gradient can account for these effects. Using the same parameter values, the model produces reasonable serial position curves and captures the changes in item and order information across study-test trials. In contrast, a prominent positional coding model cannot account for the pattern of clustering uncovered by the new analyses.

  16. Visual similarity effects in immediate verbal serial recall.

    PubMed

    Logie, R H; Della Sala, S; Wynn, V; Baddeley, A D

    2000-08-01

    The role of visual working memory in temporary serial retention of verbal information was examined in four experiments on immediate serial recall of words that varied in visual similarity and letters that varied in the visual consistency between upper and lower case. Experiments 1 and 2 involved words that were either visually similar (e.g. fly, cry, dry; hew, new, few) or were visually distinct (e.g. guy, sigh, lie; who, blue, ewe). Experiments 3 and 4 involved serial recall of both letter and case from sequences of letters chosen such that the upper- and lower-case versions were visually similar, for example Kk, Cc, Zz, Ww, or were visually dissimilar, for example Dd, Hh, Rr, Qq. Hence in the latter set, case information was encoded in terms of both the shape and the size of the letters. With both words and letters, the visually similar items resulted in poorer recall both with and without concurrent articulatory suppression. This visual similarity effect was robust and was replicated across the four experiments. The effect was not restricted to any particular serial position and was particularly salient in the recall of letter case. These data suggest the presence of a visual code for retention of visually presented verbal sequences in addition to a phonological code, and they are consistent with the use of a visual temporary memory, or visual "cache", in verbal serial recall tasks.

  17. The relationship between serial sexual murder and autoerotic asphyxiation.

    PubMed

    Myers, Wade C; Bukhanovskiy, Alexandr; Justen, Elle; Morton, Robert J; Tilley, John; Adams, Kenneth; Vandagriff, Virgil L; Hazelwood, Robert R

    2008-04-01

    This case series documents and examines the association between autoerotic asphyxiation, sadomasochism, and serial sexual murderers. Autoerotic asphyxiation, along with other paraphilias found in this population, is reviewed. Five cases of serial sexual killers who engaged in autoerotic asphyxiation were identified worldwide: four from the United States and one from Russia. Case reports for each are provided. All (100%) were found to have sexual sadism in addition to autoerotic asphyxiation. Furthermore, two (40%) had bondage fetishism, and two (40%) had transvestic fetishism, consistent with these paraphilias co-occurring in those with autoerotic asphyxiation. Overall the group averaged 4.0 lifetime paraphilias. Some possible relationships were observed between the offenders' paraphilic orientation and their modus operandi, e.g., all of these serial killers strangled victims-suggesting an association between their sadistic and asphyxiative paraphilic interests. The overlap of seemingly polar opposite paraphilias in this sample--sexual sadism and autoerotic asphyxiation--is explored from a historical and clinical perspective. Multiple commonalities shared between these five offenders and serial sexual murderers in general are addressed. A primary limitation of this study is its small sample size and empirical basis; the results may not be generalizable beyond the sample. The findings from this study support the supposition that crime scene behaviors often reflect paraphilic disturbances in those who commit serial sexual homicides.

  18. Genetic programming and serial processing for time series classification.

    PubMed

    Alfaro-Cid, Eva; Sharman, Ken; Esparcia-Alcázar, Anna I

    2014-01-01

    This work describes an approach devised by the authors for time series classification. In our approach genetic programming is used in combination with a serial processing of data, where the last output is the result of the classification. The use of genetic programming for classification, although still a field where more research in needed, is not new. However, the application of genetic programming to classification tasks is normally done by considering the input data as a feature vector. That is, to the best of our knowledge, there are not examples in the genetic programming literature of approaches where the time series data are processed serially and the last output is considered as the classification result. The serial processing approach presented here fills a gap in the existing literature. This approach was tested in three different problems. Two of them are real world problems whose data were gathered for online or conference competitions. As there are published results of these two problems this gives us the chance to compare the performance of our approach against top performing methods. The serial processing of data in combination with genetic programming obtained competitive results in both competitions, showing its potential for solving time series classification problems. The main advantage of our serial processing approach is that it can easily handle very large datasets. PMID:24032750

  19. Hemodynamics in Coronary Arterial Tree of Serial Stenoses

    PubMed Central

    Lu, Bin; Jia, Xinwei; Zhong, Liang; Kassab, Ghassan S.; Tan, Wenchang

    2016-01-01

    Serial segmental narrowing frequently occurs in humans, which alters coronary hemodynamics and further affects atherosclerotic progression and plaque formation. The objective of this study was to understand the distribution of hemodynamic parameters in the epicardial left main coronary arterial (LMCA) tree with serial stenoses reconstructed from patient computer tomography angiography (CTA) images. A finite volume method was used in conjunction with the inlet pressure wave and outlet flow resistance. The time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI) were determined from the flow field. A stenosis at a mother vessel mainly deteriorated the hemodynamics near the bifurcation while a stenosis at a daughter vessel affected the remote downstream bifurcation. In comparison with a single stenosis, serial stenoses increased the peak pressure gradient along the main trunk of the epicardial left anterior descending arterial tree by > 50%. An increased distance between serial stenoses further increased the peak pressure gradient. These findings have important implications on the diagnosis and treatment of serial coronary stenoses. PMID:27685989

  20. The relationship between serial sexual murder and autoerotic asphyxiation.

    PubMed

    Myers, Wade C; Bukhanovskiy, Alexandr; Justen, Elle; Morton, Robert J; Tilley, John; Adams, Kenneth; Vandagriff, Virgil L; Hazelwood, Robert R

    2008-04-01

    This case series documents and examines the association between autoerotic asphyxiation, sadomasochism, and serial sexual murderers. Autoerotic asphyxiation, along with other paraphilias found in this population, is reviewed. Five cases of serial sexual killers who engaged in autoerotic asphyxiation were identified worldwide: four from the United States and one from Russia. Case reports for each are provided. All (100%) were found to have sexual sadism in addition to autoerotic asphyxiation. Furthermore, two (40%) had bondage fetishism, and two (40%) had transvestic fetishism, consistent with these paraphilias co-occurring in those with autoerotic asphyxiation. Overall the group averaged 4.0 lifetime paraphilias. Some possible relationships were observed between the offenders' paraphilic orientation and their modus operandi, e.g., all of these serial killers strangled victims-suggesting an association between their sadistic and asphyxiative paraphilic interests. The overlap of seemingly polar opposite paraphilias in this sample--sexual sadism and autoerotic asphyxiation--is explored from a historical and clinical perspective. Multiple commonalities shared between these five offenders and serial sexual murderers in general are addressed. A primary limitation of this study is its small sample size and empirical basis; the results may not be generalizable beyond the sample. The findings from this study support the supposition that crime scene behaviors often reflect paraphilic disturbances in those who commit serial sexual homicides. PMID:17980531

  1. Genetic programming and serial processing for time series classification.

    PubMed

    Alfaro-Cid, Eva; Sharman, Ken; Esparcia-Alcázar, Anna I

    2014-01-01

    This work describes an approach devised by the authors for time series classification. In our approach genetic programming is used in combination with a serial processing of data, where the last output is the result of the classification. The use of genetic programming for classification, although still a field where more research in needed, is not new. However, the application of genetic programming to classification tasks is normally done by considering the input data as a feature vector. That is, to the best of our knowledge, there are not examples in the genetic programming literature of approaches where the time series data are processed serially and the last output is considered as the classification result. The serial processing approach presented here fills a gap in the existing literature. This approach was tested in three different problems. Two of them are real world problems whose data were gathered for online or conference competitions. As there are published results of these two problems this gives us the chance to compare the performance of our approach against top performing methods. The serial processing of data in combination with genetic programming obtained competitive results in both competitions, showing its potential for solving time series classification problems. The main advantage of our serial processing approach is that it can easily handle very large datasets.

  2. Synthesis, structural characterization and properties of SrAl4-xGex, BaAl4-xGex, and EuAl4-xGex (x≈0.3-0.4)—Rare examples of electron-rich phases with the BaAl4 structure type

    NASA Astrophysics Data System (ADS)

    Zhang, Jiliang; Bobev, Svilen

    2013-09-01

    Three solid solutions with the general formula AEAl4-xGex (AE=Eu, Sr, Ba; 0.32(1)≤x≤0.41(1)) have been synthesized via the aluminum self-flux method, and their crystal structures have been established from powder and single-crystal X-ray diffraction. They are isotypic and crystallize with the well-known BaAl4 structure type, adopted by the three AEAl4 end members. In all structures, Ge substitutes Al only at the 4e Wyckoff site. Results from X-rays photoelectron spectroscopy on EuAl4-xGex and EuAl4 indicate that the interactions between the Eu2+ cations and the polyanionic framework are enhanced in the Ge-doped structure, despite the slightly elevated Fermi level. Magnetic susceptibility measurements confirm the local moment magnetism, expected for the [Xe]4f7 electronic configuration of Eu2+ and suggest strong ferromagnetic interactions at cryogenic temperatures. Resistivity data from single-crystalline samples show differences between the title compounds, implying different bonding characteristics despite the close Debye temperatures. A brief discussion on the observed electron count and homogeneity ranges for AEAl4-xGex (AE=Eu, Sr, Ba) is also presented.

  3. Serial position effects in implicit and explicit tests of memory.

    PubMed

    Gershberg, F B; Shimamura, A P

    1994-11-01

    The effects of serial position at study on implicit and explicit tests of memory were investigated. Both primary and recency effects were observed in implicit tests of word-stem completion. These effects, however, were transient. No serial position effects were found in the second half of testing (Experiments 1 and 3) or when testing followed a 1-min, filled delay (Experiment 2). Serial position effects were also examined in explicit tests of cued recall. When performance on explicit cued recall was below ceiling levels, a primacy effect persisted throughout testing (Experiment 3). Similarly, in explicit tests of free recall, primacy effects were consistently observed, both with immediate testing (Experiments 1 and 3) and when testing followed a filled delay (Experiment 2).

  4. Serial processing in reading aloud: reply to Zorzi (2000).

    PubMed

    Rastle, K; Coltheart, M

    2000-06-01

    K. Rastle and M. Coltheart (1999; see also M. Coltheart & K. Rastle, 1994) reported data demonstrating that the cost of irregularity in reading aloud low-frequency exception words is modulated by the position of the irregularity in the word. They argued that these data implicated a serial process and falsified all models of reading aloud that operate solely in parallel, a conclusion that M. Zorzi (2000) challenged by successfully simulating the position of irregularity effect with such a model. Zorzi (2000) further claimed that a reanalysis of K. Rastle and M. Coltheart's (1999) data demonstrates sensitivity to grapheme-phoneme consistency (which he claimed was confounded across the position of irregularity manipulation) rather than the use of a serial process. Here, the authors argue that M. Zorzi's (2000) reanalyses were inappropriate and reassert that K. Rastle and M. Coltheart's (1999) findings are evidence for serial processing.

  5. A combination strategy for tracking the serial criminal

    NASA Astrophysics Data System (ADS)

    He, Chuan; Zhang, Yuan-Biao; Wan, Jiadi; Yu, Wenjing

    2010-08-01

    We build a Geographic Profiling Model to generate the criminal's geographical profile, by combining two complementary strategies: the Spatial Distribution Strategy and the Probability Distance Strategy. In the first strategy, we designate the mean of all the known crime sites as the anchor point, and build a Standard Deviational Ellipse Model, considering the effect of landscape. In the second strategy, we take many factors such as the buffer zone and distance decay theory into consideration and calculate the probability of the offender's residence in a certain area by using the Bayesian Theorem and the Rossmo Algorithm. Then, we combine the result of two strategies and get three search areas suit different conditions of the police to track the serial criminal. Apply the model to the English serial killer Peter Sutcliffe's case, the calculation result shows that the model can effectively be used to track serial criminal.

  6. The simultaneous chain: a new approach to serial learning.

    PubMed

    Terrace, Herbert S

    2005-04-01

    Recent advances have allowed the application of behaviorism's rigor to the control of complex cognitive tasks in animals. This article examines recent research on serially organized behavior in animals. 'Chaining theory', the traditional approach to the study of such behavior, reduces intelligent action to sequences of discrete stimulus-response units in which each overt response is evoked by a particular stimulus. However, such theories are too weak to explain many forms of serially organized cognition, both in humans and animals. By training non-human primates to produce arbitrary sequences that cannot be learned as chains of particular motor responses, the simultaneous chaining paradigm has overcome limitations of chaining theory in experiments on serial expertise, the use of numerical rules, knowledge of ordinal position, and distance and magnitude effects.

  7. Energy data base. Serial titles with ISSN listing

    SciTech Connect

    Hendricks, P.L.

    1984-03-01

    This issue of Serial Titles with ISSN Listing is the first revision of DOE/TIC-4579 to include the International Standard Serial Number (ISSN) for journals. The TIC journal authority was established to bring about conformity in citing the approximately 16,000 titles contained in this authority. It can prove to be a valuable tool in establishing the precise journal by ISSN and CODEN indication, especially for journals with the same title published in different locations. Serial Titles with ISSN Listing is comprised of two parts. Part 1 is an alphabetical listing by full title of the publication and also includes abbreviated title, CODEN, ISSN, coverage code, and country code. Part 2 is an ISSN-title correlation arranged in numeric order by ISSN and also includes the CODEN and full title.

  8. Towards time-resolved serial crystallography in a microfluidic device.

    PubMed

    Pawate, Ashtamurthy S; Šrajer, Vukica; Schieferstein, Jeremy; Guha, Sudipto; Henning, Robert; Kosheleva, Irina; Schmidt, Marius; Ren, Zhong; Kenis, Paul J A; Perry, Sarah L

    2015-07-01

    Serial methods for crystallography have the potential to enable dynamic structural studies of protein targets that have been resistant to single-crystal strategies. The use of serial data-collection strategies can circumvent challenges associated with radiation damage and repeated reaction initiation. This work utilizes a microfluidic crystallization platform for the serial time-resolved Laue diffraction analysis of macroscopic crystals of photoactive yellow protein (PYP). Reaction initiation was achieved via pulsed laser illumination, and the resultant electron-density difference maps clearly depict the expected pR(1)/pR(E46Q) and pR(2)/pR(CW) states at 10 µs and the pB1 intermediate at 1 ms. The strategies presented here have tremendous potential for extension to chemical triggering methods for reaction initiation and for extension to dynamic, multivariable analyses.

  9. Information transfer rate with serial and simultaneous visual display formats

    NASA Astrophysics Data System (ADS)

    Matin, Ethel; Boff, Kenneth R.

    1988-04-01

    Information communication rate for a conventional display with three spatially separated windows was compared with rate for a serial display in which data frames were presented sequentially in one window. For both methods, each frame contained a randomly selected digit with various amounts of additional display 'clutter.' Subjects recalled the digits in a prescribed order. Large rate differences were found, with faster serial communication for all levels of the clutter factors. However, the rate difference was most pronounced for highly cluttered displays. An explanation for the latter effect in terms of visual masking in the retinal periphery was supported by the results of a second experiment. The working hypothesis that serial displays can speed information transfer for automatic but not for controlled processing is discussed.

  10. Towards time-resolved serial crystallography in a microfluidic device

    PubMed Central

    Pawate, Ashtamurthy S.; Šrajer, Vukica; Schieferstein, Jeremy; Guha, Sudipto; Henning, Robert; Kosheleva, Irina; Schmidt, Marius; Ren, Zhong; Kenis, Paul J. A.; Perry, Sarah L.

    2015-01-01

    Serial methods for crystallography have the potential to enable dynamic structural studies of protein targets that have been resistant to single-crystal strategies. The use of serial data-collection strategies can circumvent challenges associated with radiation damage and repeated reaction initiation. This work utilizes a microfluidic crystallization platform for the serial time-resolved Laue diffraction analysis of macroscopic crystals of photoactive yellow protein (PYP). Reaction initiation was achieved via pulsed laser illumination, and the resultant electron-density difference maps clearly depict the expected pR1/pRE46Q and pR2/pRCW states at 10 µs and the pB1 intermediate at 1 ms. The strategies presented here have tremendous potential for extension to chemical triggering methods for reaction initiation and for extension to dynamic, multivariable analyses. PMID:26144226

  11. Serial control of phonology in speech production: a hierarchical model.

    PubMed

    Vousden, J I; Brown, G D; Harley, T A

    2000-09-01

    A dynamic oscillator-based model of the sequencing of phonemes in speech production (OSCAR) is described. An analysis of phoneme movement errors (anticipations, perseverations, and exchanges) from a large naturalistic speech error corpus provides a new set of data suitable for quantitative modeling and is used to derive a set of constraints that any speech-production model must address. The new computational model is shown to account for error type proportions, movement error distance gradients, the syllable-position effect, and phonological similarity effects. The model provides an alternative to frame-based accounts, serial buffer accounts, and associative chaining theories of serial order processing in speech.

  12. Serial murder in America: case studies of seven offenders.

    PubMed

    Beasley, James O

    2004-01-01

    This article summarizes and compares information on seven interviewed serial killers in an ongoing project designed to study similarities and differences among these individuals. The aim of this article is to increase our collective knowledge of the dynamics of serial murder by examining the perpetrators' backgrounds, as well as the unique ways in which they view themselves and the world around them. Although qualitative interview research alone is not sufficient to fully understand such behavior, it is useful in many ways. Some of the information discussed based on the seven offenders interviewed is compared with broader epidemiological studies, and the strengths and limitations of each type of research are discussed.

  13. Serial murder in America: case studies of seven offenders.

    PubMed

    Beasley, James O

    2004-01-01

    This article summarizes and compares information on seven interviewed serial killers in an ongoing project designed to study similarities and differences among these individuals. The aim of this article is to increase our collective knowledge of the dynamics of serial murder by examining the perpetrators' backgrounds, as well as the unique ways in which they view themselves and the world around them. Although qualitative interview research alone is not sufficient to fully understand such behavior, it is useful in many ways. Some of the information discussed based on the seven offenders interviewed is compared with broader epidemiological studies, and the strengths and limitations of each type of research are discussed. PMID:15211559

  14. In situ serial Laue diffraction on a microfluidic crystallization device

    PubMed Central

    Perry, Sarah L.; Guha, Sudipto; Pawate, Ashtamurthy S.; Henning, Robert; Kosheleva, Irina; Srajer, Vukica; Kenis, Paul J. A.; Ren, Zhong

    2014-01-01

    Renewed interest in room-temperature diffraction has been prompted by the desire to observe structural dynamics of proteins as they function. Serial crystallography, an experimental strategy that aggregates small pieces of data from a large uniform pool of crystals, has been demonstrated at synchrotrons and X-ray free-electron lasers. This work utilizes a microfluidic crystallization platform for serial Laue diffraction from macroscopic crystals and proposes that a collection of small slices of Laue data from many individual crystals is a realistic solution to the difficulties in dynamic studies of irreversible biochemical reactions. PMID:25484843

  15. Native sulfur/chlorine SAD phasing for serial femtosecond crystallography

    SciTech Connect

    Nakane, Takanori; Song, Changyong; Suzuki, Mamoru; Nango, Eriko; Kobayashi, Jun; Masuda, Tetsuya; Inoue, Shigeyuki; Mizohata, Eiichi; Nakatsu, Toru; Tanaka, Tomoyuki; Tanaka, Rie; Shimamura, Tatsuro; Tono, Kensuke; Joti, Yasumasa; Kameshima, Takashi; Hatsui, Takaki; Yabashi, Makina; Nureki, Osamu; Iwata, So; Sugahara, Michihiro

    2015-11-27

    Sulfur SAD phasing facilitates the structure determination of diverse native proteins using femtosecond X-rays from free-electron lasers via serial femtosecond crystallography. Serial femtosecond crystallography (SFX) allows structures to be determined with minimal radiation damage. However, phasing native crystals in SFX is not very common. Here, the structure determination of native lysozyme from single-wavelength anomalous diffraction (SAD) by utilizing the anomalous signal of sulfur and chlorine at a wavelength of 1.77 Å is successfully demonstrated. This sulfur SAD method can be applied to a wide range of proteins, which will improve the determination of native crystal structures.

  16. Tumoral calcinosis: Serial images to monitor successful dietary therapy

    SciTech Connect

    Manaster, B.J.; McDowell Anderson, T. Jr.

    1982-05-01

    Tumoral calcinosis involves formation of periarticular calcified soft tissue masses. Experimental evidence suggests a metabolic etiology with dietary restriction of calcium and phosphorus as beneficial therapy. We prospectively monitored serum levels of calcium, phosphorous, alkaline phosphatase, and erythrocyte sedimentation rate (ESR) while successfully treating a patient with tumoral calcinosis. The values were compared with changes on serial radiographic and radionuclide bone and gallium images. Our work suggests using serial serum phosphate levels and the ESR as the most sensitive indications of progress in dietary treatment of tumoral calcinosis.

  17. A phase width for CaGaSn. Crystal structure of mixed intermetallic Ca4Ga4+xSn4-x and SmGaxSn3-x, stability, geometry and electronic structure

    NASA Astrophysics Data System (ADS)

    Tillard, Monique

    2016-10-01

    X-ray single-crystal structure has been established for new compositions in intermetallic systems of tin and gallium. Crystals were successfully obtained in alloys prepared from elements. The structure of SmGaSn2 (cubic Pm3¯m, a=4.5778(8) Å, Z=1, R1=0.012) is described with atomic disorder at all Sn/Ga positions and the structure of Ca4Ga4.9Sn3.1 (hexagonal, P63/mmc, a=4.2233(9), c=17.601(7) Å, Z=1, R1=0.062) raises an interesting question about existence of a composition domain for CaGaSn. Finally, Ca4Ga4.9Sn3.1 should be considered as a particular composition of Ca4Ga4+xSn4-x, a compound assumed to exist in the range x ~ 0-1. Partial atomic ordering characterizes the Sn/Ga puckered layers of hexagons whose geometries are analyzed and discussed comparatively with analogous arrangements in AlB2 related hexagonal compounds. The study is supported by rigid band model and DFT calculations performed for different experimental and hypothetic arrangements.

  18. Synthesis and crystal structures of new oxyapatites BiCa4-xLax(VO4)3-x(GeO4)xO, x=1-3

    NASA Astrophysics Data System (ADS)

    Zhuravlev, V. D.; Tyutyunnik, A. P.; Zubkov, V. G.; Perelyaeva, L. A.; Baklanova, I. V.; Blinova, A. L.

    2012-10-01

    New germanate-vanadates with the general formula BiCa4-xLax(VO4)3-x(GeO4)xO, x=1-3, have been synthesized by the nitrate-citrate method and characterized. Structural refinement based on X-ray powder diffraction data showed that these compounds are isostructural with BiCa4(VO4)3O (space group P63/m (N 176), Z=2, а=9.8327-9.8755(3), and с=7.1203-7.2133(2) ). They may be viewed as continuous series of solid solutions where Ca2+ and V5+ cations in the crystal lattice of vanadate BiCa4(VO4)3O are replaced by La3+ and Ge4+ cations. In the process of substitution, the La3+ cations occupy mainly the 4f lattice sites of the germanate-vanadate oxyapatites, but the filling of the 4f and 6h lattice sites in the germanate BiCaLa3(GeO4)3 is equivalent. IR and Raman spectra were studied. The Raman spectra clearly show a two-mode behavior: the lines of GeO4 and VO4 are separated from each other, and the (V/Ge)O4 tetrahedra exhibit a quasi-independent behavior.

  19. Defects and defect healing in amorphous Si3N4-xHy: An ab initio density functional theory study

    NASA Astrophysics Data System (ADS)

    Hintzsche, L. E.; Fang, C. M.; Marsman, M.; Jordan, G.; Lamers, M. W. P. E.; Weeber, A. W.; Kresse, G.

    2013-10-01

    We present an ab initio density functional theory study of the dominant defects in hydrogenated amorphous silicon nitrides covering different stoichiometries, the influence of hydrogen, and the influence of the annealing history. Whereas nitrogen (N) lone pair states dominate the valence band edge in stoichiometric a-Si3N4, we find that K defects, threefold coordinated silicon (Si) atoms, and Si-Si bond-related states dominate electronic defect contributions in the gap for N-deficient a-Si3N4-x. Hydrogen saturates the dangling Si bonds, significantly reducing the number of electronic defects related to undercoordinated Si atoms.

  20. Within-word serial order control: Adjacent mora exchange and serial position effects in repeated single-word production.

    PubMed

    Nakayama, Masataka; Saito, Satoru

    2014-06-01

    An essential function of language processing is serial order control. Computational models of serial ordering and empirical data suggest that plan representations for ordered output of sound are governed by principles related to similarity. Among these principles, the temporal distance and edge principles at a within-word level have not been empirically demonstrated separately from other principles. Specifically, the temporal distance principle assumes that phonemes that are in the same word and thus temporally close are represented similarly. This principle would manifest as phoneme movement errors within the same word. However, such errors are rarely observed in English, likely reflecting stronger effects of syllabic constraints (i.e., phonemes in different positions within the syllable are distinctly represented). The edge principle assumes that the edges of a sequence are represented distinctly from other elements/positions. This principle has been repeatedly observed as a serial position effect in the context of phonological short-term memory. However, it has not been demonstrated in single-word production. This study provides direct evidence for the two abovementioned principles by using a speech-error induction technique to show the exchange of adjacent morae and serial position effects in Japanese four-mora words. Participants repeatedly produced a target word or nonword, immediately after hearing an aurally presented distractor word. The phonologically similar distractor words, which were created by exchanging adjacent morae in the target, induced adjacent-mora-exchange errors, demonstrating the within-word temporal distance principle. There was also a serial position effect in error rates, such that errors were mostly induced at the middle positions within a word. The results provide empirical evidence for the temporal distance and edge principles in within-word serial order control.

  1. Picture Detection in Rapid Serial Visual Presentation: Features or Identity?

    ERIC Educational Resources Information Center

    Potter, Mary C.; Wyble, Brad; Pandav, Rijuta; Olejarczyk, Jennifer

    2010-01-01

    A pictured object can be readily detected in a rapid serial visual presentation sequence when the target is specified by a superordinate category name such as "animal" or "vehicle". Are category features the initial basis for detection, with identification of the specific object occurring in a second stage (Evans & Treisman, 2005), or is…

  2. 10 CFR 32.201 - Serialization of nationally tracked sources.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Serialization of nationally tracked sources. 32.201 Section 32.201 Energy NUCLEAR REGULATORY COMMISSION SPECIFIC DOMESTIC LICENSES TO MANUFACTURE OR TRANSFER... nationally tracked sources. Each licensee who manufactures a nationally tracked source after February 6,...

  3. Phonological Similarity in Serial Recall: Constraints on Theories of Memory

    ERIC Educational Resources Information Center

    Lewandowsky, Stephan; Farrell, Simon

    2008-01-01

    In short-term serial recall, similar-sounding items are remembered more poorly than items that do not sound alike. When lists mix similar and dissimilar items, performance on the dissimilar items is of considerable theoretical interest. Farrell and Lewandowsky [Farrell, S., & Lewandowsky, S. (2003). Dissimilar items benefit from phonological…

  4. Auditory Word Serial Recall Benefits from Orthographic Dissimilarity

    ERIC Educational Resources Information Center

    Pattamadilok, Chotiga; Lafontaine, Helene; Morais, Jose; Kolinsky, Regine

    2010-01-01

    The influence of orthographic knowledge has been consistently observed in speech recognition and metaphonological tasks. The present study provides data suggesting that such influence also pervades other cognitive domains related to language abilities, such as verbal working memory. Using serial recall of auditory seven-word lists, we observed…

  5. The Primacy Model: A New Model of Immediate Serial Recall.

    ERIC Educational Resources Information Center

    Page, Michael P. A.; Norris, Dennis

    1998-01-01

    The primacy model is presented as a new model of serial recall. This model stores order information by means of the assumption that the strength of activation of successive list items decreases across list position to form a primary gradient. The model produces accurate simulation of the effects of word length, list length, and phonological…

  6. Modelling Transposition Latencies: Constraints for Theories of Serial Order Memory

    ERIC Educational Resources Information Center

    Farrell, Simon; Lewandowsky, Stephan

    2004-01-01

    Several competing theories of short-term memory can explain serial recall performance at a quantitative level. However, most theories to date have not been applied to the accompanying pattern of response latencies, thus ignoring a rich and highly diagnostic aspect of performance. This article explores and tests the error latency predictions of…

  7. Whole-pattern fitting technique in serial femtosecond nanocrystallography

    PubMed Central

    Dilanian, Ruben A.; Williams, Sophie R.; Martin, Andrew V.; Streltsov, Victor A.; Quiney, Harry M.

    2016-01-01

    Serial femtosecond X-ray crystallography (SFX) has created new opportunities in the field of structural analysis of protein nanocrystals. The intensity and timescale characteristics of the X-ray free-electron laser sources used in SFX experiments necessitate the analysis of a large collection of individual crystals of variable shape and quality to ultimately solve a single, average crystal structure. Ensembles of crystals are commonly encountered in powder diffraction, but serial crystallography is different because each crystal is measured individually and can be oriented via indexing and merged into a three-dimensional data set, as is done for conventional crystallography data. In this way, serial femtosecond crystallography data lie in between conventional crystallography data and powder diffraction data, sharing features of both. The extremely small sizes of nanocrystals, as well as the possible imperfections of their crystallite structure, significantly affect the diffraction pattern and raise the question of how best to extract accurate structure-factor moduli from serial crystallography data. Here it is demonstrated that whole-pattern fitting techniques established for one-dimensional powder diffraction analysis can be feasibly extended to higher dimensions for the analysis of merged SFX diffraction data. It is shown that for very small crystals, whole-pattern fitting methods are more accurate than Monte Carlo integration methods that are currently used. PMID:27006776

  8. When Temporal Isolation Benefits Memory for Serial Order

    ERIC Educational Resources Information Center

    Lewandowsky, Stephan; Nimmo, Lisa M.; Brown, Gordon D. A.

    2008-01-01

    According to temporal distinctiveness models, items that are temporally isolated from their neighbors during list presentation are more distinct and thus should be recalled better. Contrary to that expectation of distinctiveness views, much recent evidence has shown that forward short-term serial recall is unaffected by temporal isolation. We…

  9. Mixed-List Phonological Similarity Effects in Delayed Serial Recall

    ERIC Educational Resources Information Center

    Farrell, Simon

    2006-01-01

    Recent experiments have shown that placing dissimilar items on lists of phonologically similar items enhances accuracy of ordered recall of the dissimilar items [Farrell, S., & Lewandowsky, S. (2003). Dissimilar items benefit from phonological similarity in serial recall. "Journal of Experimental Psychology: Learning, Memory, and Cognition," 29,…

  10. Upper and lower bounds for a serial dilution test.

    PubMed

    Blodgett, Robert J

    2005-01-01

    A Poisson-binomial model estimates the concentration of a target microbe from a serial dilution test. The maximum likelihood procedure gives an equation whose solution equals the estimate of the concentration. This paper gives bounds for the solution to this equation that require only minimal calculations.

  11. Serials Pricing and the Role of the Electronic Journal.

    ERIC Educational Resources Information Center

    Metz, Paul; Gherman, Paul M.

    1991-01-01

    This third in a series of articles on scholarly communications and serials prices focuses on the possible role of electronic journals. Highlights include the increase in scientific and scholarly productivity; price differentials between private and for-profit journals; publisher's costs and profits; copyright issues; and the role of libraries and…

  12. Implementing Inquiry-Based Learning in Teaching Serial Dilutions

    ERIC Educational Resources Information Center

    Walker, Candace L.; McGill, Michael T.; Buikema, Arthur L., Jr.; Stevens, Ann M.

    2008-01-01

    The 5E model of inquiry-based learning was incorporated into a sophomore-level microbiology laboratory to increase student understanding of serial dilutions, a concept that is often difficult for most students to comprehend. Quantitative and qualitative assessments were conducted during the semester to determine the value of this approach for…

  13. Serial Killers: Academic Libraries Respond to Soaring Costs.

    ERIC Educational Resources Information Center

    McCarthy, Paul

    1994-01-01

    Discusses ways in which academic libraries are responding to rising costs of serials. Topics addressed include pricing by publishers; the effect of journal cancellations on research activities; interlibrary loans and document delivery services; coordinated cancelling; electronic journals; and experiences at the University of Arizona. (LRW)

  14. Child serial murder-psychodynamics: closely watched shadows.

    PubMed

    Turco, R

    2001-01-01

    There is a malignant transformation in object relations resulting in an identification with an omnipotent and cruel object resulting in an identity transformation. If the tension, desperation, and dissociation increase, serial murder becomes spree murder. The presence of pathological narcissism and psychopathic tendencies are of diagnostic significance in understanding the murderer's personality functioning and motivation to kill. Meloy (1988) considered the degree of sadism and aggression combined with narcissistic qualities to reflect the "malignancy" of the psychopathic disturbance where gratification (of aggression) occurs in the service of narcissistic functioning--that is, cruelty toward others in the form of a triumphant victory over a rejecting object. Meloy also believes that dissociation is ubiquitious in the psychopath. The initial murder of the serial murderer may reflect a "new identity." The pathological object-relations of narcissism and the malignant narcissism are important diagnostic indicators in the personality functioning of serial killers and the occurrence of these phenomena is a significant factor in the formation of the personalities of serial killers, their inner motivations, and their pattern of commission.

  15. Union List of Serials in Pacific Island Libraries.

    ERIC Educational Resources Information Center

    Cohen, Arlene G., Comp.; Yoshida, Patricia, Comp.

    This union list contains the serial holdings from Pacific Island libraries, including the University of the South Pacific Library (Fiji), the University of Guam Robert F. Kennedy Library, Guam Public Library, College of Micronesia-FSM Library, College of the Marshall Islands Library, Micronesian Seminar Library, Palau Community College Library,…

  16. Guidelines for the Compilation of Union Catalogues of Serials.

    ERIC Educational Resources Information Center

    International Federation of Library Associations and Institutions, London (England).

    Intended for use in countries planning the establishment of new union catalogs, as well as in countries with long established traditions of library resource sharing, this document provides guiding principles and outlines standard methods and practices for the compilation of union catalogs of serials. Following definitions of relevant terminology…

  17. Prior-List Intrusions in Serial Recall Are Positional

    ERIC Educational Resources Information Center

    Osth, Adam F.; Dennis, Simon

    2015-01-01

    Henson (1996) provided a number of demonstrations of error patterns in serial recall that contradict chaining models. One such error pattern concerned when participants make intrusions from prior lists: Rather than originating from random positions in the prior list, intrusions tend to be recalled in the same position as their position in the…

  18. Nymphalid eyespot serial homologues originate as a few individualized modules.

    PubMed

    Oliver, Jeffrey C; Beaulieu, Jeremy M; Gall, Lawrence F; Piel, William H; Monteiro, Antónia

    2014-07-22

    Serial homologues are repeated traits that share similar development but occur in different parts of the body. Variation in number of repeats accounts for substantial diversity in animal form and considerable work has focused on identifying the factors accounting for this variation. Little is known, however, about how serial homologues originally become repeated, or about the relative timing of repeat individuation relative to repeat origin. Here, we show that the serially repeated eyespots on nymphalid butterfly wings most likely arose as a small cluster of units on the ventral hindwing that were later co-opted to the dorsal and anterior wing surfaces. Based on comparative analyses of over 400 species, we found support for a model of eyespot origin followed by redeployment, rather than by the conventional model, where eyespots arose as a complete row of undifferentiated units that later gained individuation. In addition, eyespots most likely evolved from simpler pattern elements, single-coloured spots, which were already individuated among different wing sectors. Finally, the late appearance of eyespots on the dorsal, hidden wing surface further suggests that these novel complex traits originally evolved for one function (thwarting predator attacks) and acquired a second function (sexual signalling) when moved to a different body location. This broad comparative analysis illustrates how serial homologues may initially evolve as a few units serving a particular function and subsequently become repeated in novel body locations with new functions. PMID:24870037

  19. Fitting a Serial Correlation Pattern to Repeated Observations.

    ERIC Educational Resources Information Center

    Edwards, Lynne K.

    1991-01-01

    When repeated observations are taken at equal time intervals, a simple form of a stationary time series structure may be fitted to the observations. Use of correction factors is discussed. A computer simulation method is used to investigate power advantages of fitting a serial correlation pattern to repeated observations. (TJH)

  20. Analysis of aging in lager brewing yeast during serial repitching.

    PubMed

    Bühligen, Franziska; Lindner, Patrick; Fetzer, Ingo; Stahl, Frank; Scheper, Thomas; Harms, Hauke; Müller, Susann

    2014-10-10

    Serial repitching of brewing yeast inoculates is an important economic factor in the brewing industry, as their propagation is time and resource intensive. Here, we investigated whether replicative aging and/or the population distribution status changed during serial repitching in three different breweries with the same brewing yeast strain but different abiotic backgrounds and repitching regimes with varying numbers of reuses. Next to bud scar numbers the DNA content of the Saccharomyces pastorianus HEBRU cells was analyzed. Gene expression patterns were investigated using low-density microarrays with genes for aging, stress, storage compound metabolism and cell cycle. Two breweries showed a stable rejuvenation rate during serial repitching. In a third brewery the fraction of virgin cells varied, which could be explained with differing wort aeration rates. Furthermore, the number of bud scars per cell and cell size correlated in all 3 breweries throughout all runs. Transcriptome analyses revealed that from the 6th run on, mainly for the cells positive gene expression could be seen, for example up-regulation of trehalose and glycogen metabolism genes. Additionally, the cells' settling in the cone was dependent on cell size, with the lowest and the uppermost cone layers showing the highest amount of dead cells. In general, cells do not progressively age during extended serial repitching. PMID:25026460

  1. 10 CFR 32.201 - Serialization of nationally tracked sources.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Serialization of nationally tracked sources. 32.201 Section 32.201 Energy NUCLEAR REGULATORY COMMISSION SPECIFIC DOMESTIC LICENSES TO MANUFACTURE OR TRANSFER... nationally tracked sources. Each licensee who manufactures a nationally tracked source after February 6,...

  2. Process to restore obliterated serial numbers on metal surfaces

    NASA Technical Reports Server (NTRS)

    Young, S. G.; Parker, B.; Chisum, W. J.

    1974-01-01

    Metal smeared into grooves of serial numbers by grinding or filing can be cleaned out by process called cavitation. Ultrasonic vibrator generates very high frequency vibrations in water which create millions of microscopic bubbles. Cavitation bubbles impact metal surface at thousands of pounds per square inch pressure. Metal particles filling grooves are broken away.

  3. Counterbalancing for Serial Order Carryover Effects in Experimental Condition Orders

    ERIC Educational Resources Information Center

    Brooks, Joseph L.

    2012-01-01

    Reactions of neural, psychological, and social systems are rarely, if ever, independent of previous inputs and states. The potential for serial order carryover effects from one condition to the next in a sequence of experimental trials makes counterbalancing of condition order an essential part of experimental design. Here, a method is proposed…

  4. 27 CFR 24.260 - Serial numbers or filling date.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Serial numbers or filling date. 24.260 Section 24.260 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS WINE Storage, Treatment and Finishing of Wine...

  5. 27 CFR 24.260 - Serial numbers or filling date.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Serial numbers or filling date. 24.260 Section 24.260 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS WINE Storage, Treatment and Finishing of Wine...

  6. Child serial murder-psychodynamics: closely watched shadows.

    PubMed

    Turco, R

    2001-01-01

    There is a malignant transformation in object relations resulting in an identification with an omnipotent and cruel object resulting in an identity transformation. If the tension, desperation, and dissociation increase, serial murder becomes spree murder. The presence of pathological narcissism and psychopathic tendencies are of diagnostic significance in understanding the murderer's personality functioning and motivation to kill. Meloy (1988) considered the degree of sadism and aggression combined with narcissistic qualities to reflect the "malignancy" of the psychopathic disturbance where gratification (of aggression) occurs in the service of narcissistic functioning--that is, cruelty toward others in the form of a triumphant victory over a rejecting object. Meloy also believes that dissociation is ubiquitious in the psychopath. The initial murder of the serial murderer may reflect a "new identity." The pathological object-relations of narcissism and the malignant narcissism are important diagnostic indicators in the personality functioning of serial killers and the occurrence of these phenomena is a significant factor in the formation of the personalities of serial killers, their inner motivations, and their pattern of commission. PMID:11685995

  7. Forensic sexology: paraphilic serial rape (biastophilia) and lust murder (erotophonophilia).

    PubMed

    Money, J

    1990-01-01

    Forensic sexology is not synonymous with either forensic psychiatry or forensic psychology. It is a specialty in its own right, and is needed in the courtroom. Paraphilic sex offenders on trial are misrepresented as being, by their own choice, psychopathic or sociopathic deviates. They are unable to explain their paraphilic criminality to either themselves or society. In a case of serial rape and serial lust murder here presented, the contributory causes are examined and differentiated as hereditary predisposition, hormonal functioning; pathological relationships, sexual abuse; and syndrome overlap with bipolar disorder, schizoid disorder, antisocial personality disorder, epilepsy, and multiple personality. The precipitating causes were differentiated as childhood head injuries, and adult head injury at age 20. Left impact trauma and sexological trauma were sequelae of the adult injury. The full range of diagnostic resources was not available for a prisoner on death row. Capital punishment has not prevented the reemergence in each new generation of serial rape and serial lust murder as an epidemiological, public health problem. Punishment is an ineffectual substitute for epidemiological research into cause, effect, and prevention.

  8. Serials Standards in Convergence: ISBD(S) Developments.

    ERIC Educational Resources Information Center

    Parent, Ingrid

    This paper provides an update on the revision process undertaken to produce a new, relevant, and useful ISBD(S) (International Standard Bibliographic Description) standard for describing serial publications in both print and electronic formats. Highlights include: the concept of "integrating resource," i.e., a bibliographic resource that is added…

  9. Dyslexia: The Effects of Visual Memory and Serial Recall.

    ERIC Educational Resources Information Center

    McIntyre, Thomas C.

    Research on the role of visual memory and serial recall in dyslexia is reviewed. Findings touch on feature theory, which proposes that information is held in the form of "features," and that students for example learn to discriminate letters by marking certain identifiable aspects. Other studies are described which focus on speed of processing…

  10. Nymphalid eyespot serial homologues originate as a few individualized modules.

    PubMed

    Oliver, Jeffrey C; Beaulieu, Jeremy M; Gall, Lawrence F; Piel, William H; Monteiro, Antónia

    2014-07-22

    Serial homologues are repeated traits that share similar development but occur in different parts of the body. Variation in number of repeats accounts for substantial diversity in animal form and considerable work has focused on identifying the factors accounting for this variation. Little is known, however, about how serial homologues originally become repeated, or about the relative timing of repeat individuation relative to repeat origin. Here, we show that the serially repeated eyespots on nymphalid butterfly wings most likely arose as a small cluster of units on the ventral hindwing that were later co-opted to the dorsal and anterior wing surfaces. Based on comparative analyses of over 400 species, we found support for a model of eyespot origin followed by redeployment, rather than by the conventional model, where eyespots arose as a complete row of undifferentiated units that later gained individuation. In addition, eyespots most likely evolved from simpler pattern elements, single-coloured spots, which were already individuated among different wing sectors. Finally, the late appearance of eyespots on the dorsal, hidden wing surface further suggests that these novel complex traits originally evolved for one function (thwarting predator attacks) and acquired a second function (sexual signalling) when moved to a different body location. This broad comparative analysis illustrates how serial homologues may initially evolve as a few units serving a particular function and subsequently become repeated in novel body locations with new functions.

  11. Serial Back-Plane Technologies in Advanced Avionics Architectures

    NASA Technical Reports Server (NTRS)

    Varnavas, Kosta

    2005-01-01

    Current back plane technologies such as VME, and current personal computer back planes such as PCI, are shared bus systems that can exhibit nondeterministic latencies. This means a card can take control of the bus and use resources indefinitely affecting the ability of other cards in the back plane to acquire the bus. This provides a real hit on the reliability of the system. Additionally, these parallel busses only have bandwidths in the 100s of megahertz range and EMI and noise effects get worse the higher the bandwidth goes. To provide scalable, fault-tolerant, advanced computing systems, more applicable to today s connected computing environment and to better meet the needs of future requirements for advanced space instruments and vehicles, serial back-plane technologies should be implemented in advanced avionics architectures. Serial backplane technologies eliminate the problem of one card getting the bus and never relinquishing it, or one minor problem on the backplane bringing the whole system down. Being serial instead of parallel improves the reliability by reducing many of the signal integrity issues associated with parallel back planes and thus significantly improves reliability. The increased speeds associated with a serial backplane are an added bonus.

  12. Nymphalid eyespot serial homologues originate as a few individualized modules

    PubMed Central

    Oliver, Jeffrey C.; Beaulieu, Jeremy M.; Gall, Lawrence F.; Piel, William H.; Monteiro, Antónia

    2014-01-01

    Serial homologues are repeated traits that share similar development but occur in different parts of the body. Variation in number of repeats accounts for substantial diversity in animal form and considerable work has focused on identifying the factors accounting for this variation. Little is known, however, about how serial homologues originally become repeated, or about the relative timing of repeat individuation relative to repeat origin. Here, we show that the serially repeated eyespots on nymphalid butterfly wings most likely arose as a small cluster of units on the ventral hindwing that were later co-opted to the dorsal and anterior wing surfaces. Based on comparative analyses of over 400 species, we found support for a model of eyespot origin followed by redeployment, rather than by the conventional model, where eyespots arose as a complete row of undifferentiated units that later gained individuation. In addition, eyespots most likely evolved from simpler pattern elements, single-coloured spots, which were already individuated among different wing sectors. Finally, the late appearance of eyespots on the dorsal, hidden wing surface further suggests that these novel complex traits originally evolved for one function (thwarting predator attacks) and acquired a second function (sexual signalling) when moved to a different body location. This broad comparative analysis illustrates how serial homologues may initially evolve as a few units serving a particular function and subsequently become repeated in novel body locations with new functions. PMID:24870037

  13. Building a Virtual National Serials Collection Using the MEADS System.

    ERIC Educational Resources Information Center

    Lim, Edward

    1998-01-01

    The Australian university system can fund the creation of a scholarly collection of serials for use by the nation by increasing the average expenditure on libraries from 5.1% to 5.3% of total university expenditure. Once the national collection has been built, virtual access can be provided using a Web-based model called MEADS (Monash Electronic…

  14. Kiondo Bag Boutique: A Serial Case for Introductory Financial Accounting

    ERIC Educational Resources Information Center

    Siriwardane, Harshini P.

    2014-01-01

    Kiondo Bag Boutique is a hypothetical serial case involving a start-up retail business. The case evolves from an ambitious business idea to a successful business. Through the evolving business, the importance of accounting information is highlighted. Different iterations are used to illustrate the role of accounting in serving and managing…

  15. Reconstruct: a free editor for serial section microscopy.

    PubMed

    Fiala, J C

    2005-04-01

    Many microscopy studies require reconstruction from serial sections, a method of analysis that is sometimes difficult and time-consuming. When each section is cut, mounted and imaged separately, section images must be montaged and realigned to accurately analyse and visualize the three-dimensional (3D) structure. Reconstruct is a free editor designed to facilitate montaging, alignment, analysis and visualization of serial sections. The methods used by Reconstruct for organizing, transforming and displaying data enable the analysis of series with large numbers of sections and images over a large range of magnifications by making efficient use of computer memory. Alignments can correct for some types of non-linear deformations, including cracks and folds, as often encountered in serial electron microscopy. A large number of different structures can be easily traced and placed together in a single 3D scene that can be animated or saved. As a flexible editor, Reconstruct can reduce the time and resources expended for serial section studies and allows a larger tissue volume to be analysed more quickly.

  16. INTERPRETATIONS OF ELECTRON MICROGRAPHS OF SINGLE AND SERIAL SECTIONS

    PubMed Central

    Williams, Robley C.; Kallman, Frances

    1955-01-01

    A method of securing serial sections for electron microscopy is described. Serial sections present certain anomalies of interpretation of a nature such that a complete and detailed three-dimensional reconstruction of the sectioned tissue cannot be made. These anomalies are discussed, as well as those which have been encountered in the interpretation of single sections. Observations of the following kinds have been made in an attempt to elucidate the interpretation of single and serial sections: differing methods of mounting adjacent sections, observation of the same section by high-angle stereoscopy, and examination of sections which have been shadowed prior to and subsequent to electron microscopy. It is found that the appearance of sections is independent of the choice of side to be placed against the formvar films. Stereoscopy shows that the appearance of fine structures is strongly dependent upon the direction of the penetrating electron beam with respect to the plane of the structures. Stereoscopy, combined with shadowing, shows quantitatively that extensive sublimation of polymer occurs upon normal exposure in the electron microscope. Observation of sections shadowed prior to electron microscopy indicates that varying amounts of material are removed between sections by the action of microtomy; i.e., it is probable that the sum of the thicknesses of several serial sections is considerably less than the total thickness of material removed from the block. It is believed that this effect, combined with the effect of sublimation, aids in explaining the failure of adjacent sections to exhibit continuity in their detailed structures. PMID:13242595

  17. Problems of the National Library of Medicine Classification for Serials

    ERIC Educational Resources Information Center

    Sophanodorn, Kanchana

    1971-01-01

    A brief history of the development of serial classification patterns from the National Library of Medicine scheme is followed by the enumeration of some of the difficulties encountered by medical libraries attempting to use the scheme. Solutions to the problems utilized by five large medical libraries are described in detail. (6 references)…

  18. Investigation of carbon-coated lithiated Li{sub 4+x}Ti{sub 5}O{sub 12}/C for lithium-ion batteries

    SciTech Connect

    Pan, Mengjie; Zhang, Lin; Gong, Lijun; Liu, Hongbo; Chen, Yuxi

    2015-11-15

    Highlights: • Lithiated Li{sub 4+x}Ti{sub 5}O{sub 12}/C with pre-stored active Li ions has been synthesized. • The first-cycle coulombic efficiency of Li{sub 4+x}Ti{sub 5}O{sub 12}/C is over 100%. • Li{sub 4+x}Ti{sub 5}O{sub 12}/C displays excellent cyclic stability and capacity retention. • TiO{sub 2} nanoparticles and carbon coating are necessary for formation of Li{sub 4+x}Ti{sub 5}O{sub 12}/C. - Abstract: Carbon-coated Li{sub 4}Ti{sub 5}O{sub 12} and lithiated Li{sub 4+x}Ti{sub 5}O{sub 12} anode materials have been synthesized using nanosized anatase TiO{sub 2} and commercial TiO{sub 2} with mixed structure as Ti sources, respectively. Microstructural investigation indicates that Li{sub 4}Ti{sub 5}O{sub 12} and Li{sub 4+x}Ti{sub 5}O{sub 12} are covered by amorphous carbon layers with thickness of 2–3 nm. Their electrochemical performance has been evaluated, which indicates that an amount of active Li ions have been pre-stored in the Li{sub 4+x}Ti{sub 5}O{sub 12} lattice during solid-state synthesis, resulting in its first-cycle coulombic efficiency over 100%. Further, Li{sub 4+x}Ti{sub 5}O{sub 12}/C exhibits higher cyclic capacities than Li{sub 4}Ti{sub 5}O{sub 12}/C at different current density. The reversible charge capacity retention of Li{sub 4+x}Ti{sub 5}O{sub 12}/C reaches 98.5% after 100 cycles, which indicates that Li{sub 4+x}Ti{sub 5}O{sub 12}/C is promising candidate anode material for long lifetime lithium-ion batteries. The formation mechanism of Li{sub 4+x}Ti{sub 5}O{sub 12}/C has been discussed, in which the nanosized anatase TiO{sub 2} with high chemical activity and the carbon coating play key roles for the formation of Li{sub 4+x}Ti{sub 5}O{sub 12}/C.

  19. Serials Management in the Electronic Era: Papers in Honor of Peter Gellatly, Founding Editor of "The Serials Librarian."

    ERIC Educational Resources Information Center

    Cole, Jim, Ed.; Williams, James W., Ed.

    This book assesses progress and technical changes in the field of serials management and anticipates future directions and challenges for librarians. The book consists of 18 chapters: (1) "Introduction" (Jim Cole and James W. Williams); (2) "Peter Gellatly--Editor with a Deft Touch" (Ruth C. Carter); (3) "The "Deseret News" Web Edition" (Stewart…

  20. Adolescent exposure to methylphenidate impairs serial pattern learning in the serial multiple choice (SMC) task in adult rats.

    PubMed

    Rowan, James D; McCarty, Madison K; Kundey, Shannon M A; Osburn, Crystal D; Renaud, Samantha M; Kelley, Brian M; Matoushek, Amanda Willey; Fountain, Stephen B

    2015-01-01

    The long-term effects of adolescent exposure to methylphenidate (MPD) on adult cognitive capacity are largely unknown. We utilized a serial multiple choice (SMC) task, which is a sequential learning paradigm for studying complex learning, to observe the effects of methylphenidate exposure during adolescence on later serial pattern acquisition during adulthood. Following 20.0mg/kg/day MPD or saline exposure for 5 days/week for 5 weeks during adolescence, male rats were trained to produce a highly structured serial response pattern in an octagonal operant chamber for water reinforcement as adults. During a transfer phase, a violation to the previously-learned pattern structure was introduced as the last element of the sequential pattern. Results indicated that while rats in both groups were able to learn the training and transfer patterns, adolescent exposure to MPD impaired learning for some aspects of pattern learning in the training phase which are learned using discrimination learning or serial position learning. In contrast adolescent exposure to MPD had no effect on other aspects of pattern learning which have been shown to tap into rule learning mechanisms. Additionally, adolescent MPD exposure impaired learning for the violation element in the transfer phase. This indicates a deficit in multi-item learning previously shown to be responsible for violation element learning. Thus, these results clearly show that adolescent MPD produced multiple cognitive impairments in male rats that persisted into adulthood long after MPD exposure ended.

  1. Study of the anisotropic dielectric behavior of Rb1-x(NH4)xH2PO4 (x=0.15 and 0.17) mixed crystals

    NASA Astrophysics Data System (ADS)

    Noh, Keum Hwan; Kwun, Sook-Il; Yoon, Jong-Gul

    2000-07-01

    The complex dielectric constants and polarization of the mixed crystals of Rb1-x(NH4)xH2PO4 (RADP) with x=0.15 and 0.17 have been measured along the tetragonal a and c axes as a function of temperature. Phase coexistence of ferroelectric order and proton glass in RADP can be confirmed from a dielectric dispersion distinguished from the ferroelectric domain wall freezing at low temperature. The dielectric dispersion, which was ascribed to the proton glass state, occurred at much lower temperatures compared to pure proton glass composition. The detection of depolarization after field-cooling or zero-field cooling the sample, showed that the ferroelectric domain and polarization were retained in the glass freezing process. The result is qualitatively consistent with the expectation of the mean-field model in the presence of macroscopic polarization. The phase coexistence may be a common feature of KH2PO4 family mixed crystals.

  2. Thermoelectric and Magnetic Properties of Pt-Substituted {BaFe_{4-{x}}Pt_{{x}}Sb_{12}} Compounds

    NASA Astrophysics Data System (ADS)

    Sertkol, Murat; Ballıkaya, Sedat; Aydoğdu, Fatih; Güler, Adil; Özdemir, Mustafa; Öner, Yıldırhan

    2016-08-01

    {BaFe_{4-{x}}Pt_{{x}}Sb_{12}} (x = 0, 0.1, 0.2) compounds were prepared by melting and annealing, followed by a spark plasma sintering method. Low-temperature thermoelectric and magnetic properties were investigated based on Seebeck coefficient, electrical and thermal conductivity and magnetization measurements. The structural properties of {BaFe_{4-{x}}Pt_{{x}}Sb_{12}} (x = 0, 0.1, 0.2) compounds were ascertained by powder x-ray diffraction analysis, confirming that all samples have a main phase of a skutterudite structure with the space group Im{bar{3}} . The lattice parameters obtained, 9.202(5), 9.199(5) and 9.202(1) Å for x = 0, 0.1 and 0.2, respectively, were found consistent with literature. The Seebeck coefficient sign shows that holes are dominant carriers in all compounds. The local maximum Seebeck coefficient was observed around 50 K which may be a trace of paramagnon-drag effect of charge carriers. Thermal conductivity and electrical resistivity measurements were carried out between 4.2 and 300 K. Temperature dependence of electrical resistivity reflects that all samples show semi-metallic behavior in our temperature range of 4.2-300 K. Samples for x = 0.1 and x = 0.2 show Kondo-like behavior. In magnetization measurement, we observe that there are two successive magnetic transitions in Pt-substituted compounds; however, there is only one (transition from a paramagnetic state to long-range magnetic ordering) in Pt-free compounds. In Pt-substituted compounds, the first transition appears at T _{ c} = 48 K. In addition, the second transition is observed at T _{ irr} = 30 K where an intermediate state is observed before the magnetic ordering transforms to an irreversible ferromagnetic state. We concluded that Pt substitution on the Fe side effectual on the thermoelectric and magnetic properties of {BaFe_{4-{x}}Pt_{{x}}Sb_{12}} (x = 0, 0.1, 0.2) compounds.

  3. 9 CFR 114.14 - Extension of expiration date for a serial or subserial.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... PRODUCTION REQUIREMENTS FOR BIOLOGICAL PRODUCTS § 114.14 Extension of expiration date for a serial or... allowed in the filed Outline of Production. (1) Serials are approved for redating under the condition that... serial or subserial. 114.14 Section 114.14 Animals and Animal Products ANIMAL AND PLANT HEALTH...

  4. 9 CFR 114.14 - Extension of expiration date for a serial or subserial.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PRODUCTION REQUIREMENTS FOR BIOLOGICAL PRODUCTS § 114.14 Extension of expiration date for a serial or... allowed in the filed Outline of Production. (1) Serials are approved for redating under the condition that... serial or subserial. 114.14 Section 114.14 Animals and Animal Products ANIMAL AND PLANT HEALTH...

  5. Long-Term Phonological Knowledge Supports Serial Ordering in Working Memory

    ERIC Educational Resources Information Center

    Nakayama, Masataka; Tanida, Yuki; Saito, Satoru

    2015-01-01

    Serial ordering mechanisms have been investigated extensively in psychology and psycholinguistics. It has also been demonstrated repeatedly that long-term phonological knowledge contributes to serial ordering. However, the mechanisms that contribute to serial ordering have yet to be fully understood. To understand these mechanisms, we demonstrate…

  6. A SERIALS DATA PROGRAM FOR SCIENCE AND TECHNOLOGY, RESULTS OF A FEASIBILITY STUDY. FINAL REPORT.

    ERIC Educational Resources Information Center

    CREAGER, WILLIAM A.; SPARKS, DAVID E.

    THIS REPORT PRESENTS THE RESULTS OF A STUDY OF THE FEASIBILITY OF ESTABLISHING A CONTINUING NATIONAL INVENTORY OF THE WORLD'S SCIENTIFIC AND TECHNICAL SERIALS. THE MAJOR TECHNICAL, OPERATIONAL, AND ECONOMIC FACTORS INVOLVED IN THE IMPLEMENTATION AND OPERATION OF SUCH A SERIALS DATA PROGRAM HAVE BEEN EXAMINED. THE BASIC PARAMETERS OF A SERIALS DATA…

  7. Parity violation energies of C4H4X2 molecules for X = O, S, Se, Te and Po†

    NASA Astrophysics Data System (ADS)

    Pelloni, Stefano; Faglioni, Francesco; Lazzeretti, Paolo

    2013-09-01

    Parity-violating contributions, with the same magnitude but opposite sign, to the energies of 1,2 enantiomers of dioxin, dithiin, diselenin, ditellurin and dipolonin have been calculated. Theoretical predictions, which can be classified among the largest reported so far, indicate that the P enantiomer is energetically more stable than M. As expected, parity-violating effects increase with the first power of the neutron number and the fourth power of the atomic number for X = O, S, Se, Te and Po. The trend predicted by Laerdahl and Schwerdtfeger [Phys. Rev. A 60, 4439 (1999)] and by Berger [J. Chem. Phys. 129, 154105 (2008)] for H2X2 molecules, characterised by free rotation about the X-X internuclear axis, is therefore confirmed for the series of more rigid C4H4X2 compounds, in which limited deformations can take place.

  8. Mechanism of the Band Gap Opening across the Order-Disorder Transition of Si(111)4x1-In

    SciTech Connect

    Gonzalez, Carlos M; Guo, Jianchang; Ortega, J.; Flores, Fernando; Weitering, Harm H

    2009-03-01

    The ground state properties of indium atom chains on the Si(111)8 x 2-In surface and the nature of their insulator-metal (IM) transition near 120 K are under intense dispute. We compare experimental scanning tunneling microscopy (STM) images of the low temperature (LT) 8 x 2 phase with STM image calculations from Density Functional Theory (DFT). Our LT studies clearly indicate the existence of a frozen shear distortion between neighboring atom chains, resulting in the formation of indium hexagons. Tunneling spectra furthermore indicate that the IM transition coincides with the collapse of a -0.3 eV surface-state band gap at the r point of the 4 x 2 Brillouin zone. This implies that the IM transition is driven by a shear phonon, not by Fermi surface nesting.

  9. An automated serial Grinding, Imaging and Reconstruction Instrument (GIRI) for digital modeling of samples with weak density contrasts

    NASA Astrophysics Data System (ADS)

    Maloof, A. C.; Samuels, B.; Mehra, A.; Spatzier, A.

    2013-12-01

    We present the first results from the new Princeton University Grinder Lab dedicated to the digital reconstruction of hidden objects through serial grinding and imaging. The purpose of a destructive technique like serial grinding is to facilitate the discovery of embedded objects with weak density contrasts outside the sensitivity limits of X-ray CT-scanning devices (Feature segmentation and object reconstruction are based on color and textural contrasts in the stack of images rather than density). The device we have developed is a retrofit imaging station designed for a precision CNC surface. The instrument is capable of processing a sample 20x25x40 cm in size at 1 micron resolution in x, y and z axes. Directly coupled to the vertical axis of the grinder is an 80 megapixel medium format camera and specialty macro lens capable of imaging a 4x5 cm surface at 5 micron resolution in full 16 bit color. The system is automated such that after each surface grind, the sample is cleaned, travels to the opposite end of the bed from the grinder wheel, is photographed, and then moved back to the grinding position. This process establishes a comprehensive archive of the specimen that is used for digital reconstruction and quantitative analysis. For example, in one night, a 7 cm thick sample can be imaged completely at 20 micron horizontal and vertical resolution without human supervision. Some of the initial results we present here include new digital reconstructions of early animal fossils, 3D sedimentary bedforms, the size and shape distribution of chondrules in chondritic meteorites, and the porosity structure of carbonate cemented reservoir rocks.

  10. [Some criminological and psychopathologic reflexions about serial crimes].

    PubMed

    Romi, Juan Carlos

    2011-01-01

    This article reviews the concept of serial crime, including murder as well as any action for the purpose of inflicting bodily harm upon any person. It characterizes three types of multi-murderers: serial killers, mass murderers, and spree killers. These offenders often have a specific (ritual) behavior that is idiosyncratic and repeated on each crime, which allows the psychological profiling of the murderer. Examples, a psychopathological background, and a description of both their criminal behavior and dynamics are provided for each of these criminals. They are further classified according to their different motivations: psychotic, prophetic or enlightened, pleasure, secondary or pecuniary profits, power or control. Finally, the author shares his personal experience over 20 years in the assessment of sexual offenders.

  11. Theoretical Positioning Accuracy for Serial and Parallel Kinematic Structure

    NASA Astrophysics Data System (ADS)

    Kurekova, Eva; Halaj, Martin; Omachelová, Milada; Martišovitš, Ilja

    2014-10-01

    Modern production machines employ complex kinematic structures that shall enhance their performance. As those machines are very sophisticated electro-mechanical structures, their design is time consuming and financially demanding. Therefore, designers search for new possibilities how to estimate future properties of the machine as early as in the design phase. The paper gives a brief introduction to the adoption of methodology of measurement uncertainties into the design of production machines. The adapted methodology enables to estimate the theoretical positioning accuracy of the machine end effector that is one of the important indicators of machine performance. Both serial and parallel kinematic structures are considered in the paper. Methodology and sample calculations of theoretical positioning accuracy are presented for serial kinematic structure (represented by advanced plasma cutting head) and parallel kinematic structure, represented by one specific design named Tricept.

  12. Serial position effects in social transmission of food preference.

    PubMed

    Juárez-Maldonado, C Edith; Ortega-Saavedra, Guadalupe; Huichan-Olivares, Francisco; Gómez-Romero, José; Cruz-Morales, Sara E; Arriaga-Ramírez, J C Pedro

    2006-11-01

    The serial position effect in Long-Evans rats was evaluated in two experiments. In Experiment 1, the effect in a group for which an interstimulus interval (ISI) was introduced between items in a list of demonstrators was compared with that in a group without an ISI. With an ISI, a recency effect was produced. In Experiment 2, a serial position effect group was compared with four groups in which either the distinctiveness or the context of the middle item was changed, relative to the items on either side of it. A von Restorff effect was produced when a rat from a different strain was used as a demonstrator in Position 2. The results for Experiment 1 are discussed in relation to interstimulus effects in monkeys and those for Experiment 2 with respect to changes in the physical properties of middle items.

  13. [Some criminological and psychopathologic reflexions about serial crimes].

    PubMed

    Romi, Juan Carlos

    2011-01-01

    This article reviews the concept of serial crime, including murder as well as any action for the purpose of inflicting bodily harm upon any person. It characterizes three types of multi-murderers: serial killers, mass murderers, and spree killers. These offenders often have a specific (ritual) behavior that is idiosyncratic and repeated on each crime, which allows the psychological profiling of the murderer. Examples, a psychopathological background, and a description of both their criminal behavior and dynamics are provided for each of these criminals. They are further classified according to their different motivations: psychotic, prophetic or enlightened, pleasure, secondary or pecuniary profits, power or control. Finally, the author shares his personal experience over 20 years in the assessment of sexual offenders. PMID:22091451

  14. Lipidic cubic phase serial millisecond crystallography using synchrotron radiation

    PubMed Central

    Nogly, Przemyslaw; James, Daniel; Wang, Dingjie; White, Thomas A.; Zatsepin, Nadia; Shilova, Anastasya; Nelson, Garrett; Liu, Haiguang; Johansson, Linda; Heymann, Michael; Jaeger, Kathrin; Metz, Markus; Wickstrand, Cecilia; Wu, Wenting; Båth, Petra; Berntsen, Peter; Oberthuer, Dominik; Panneels, Valerie; Cherezov, Vadim; Chapman, Henry; Schertler, Gebhard; Neutze, Richard; Spence, John; Moraes, Isabel; Burghammer, Manfred; Standfuss, Joerg; Weierstall, Uwe

    2015-01-01

    Lipidic cubic phases (LCPs) have emerged as successful matrixes for the crystallization of membrane proteins. Moreover, the viscous LCP also provides a highly effective delivery medium for serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs). Here, the adaptation of this technology to perform serial millisecond crystallography (SMX) at more widely available synchrotron microfocus beamlines is described. Compared with conventional microcrystallography, LCP-SMX eliminates the need for difficult handling of individual crystals and allows for data collection at room temperature. The technology is demonstrated by solving a structure of the light-driven proton-pump bacteriorhodopsin (bR) at a resolution of 2.4 Å. The room-temperature structure of bR is very similar to previous cryogenic structures but shows small yet distinct differences in the retinal ligand and proton-transfer pathway. PMID:25866654

  15. Molluscan engrailed expression, serial organization, and shell evolution

    NASA Technical Reports Server (NTRS)

    Jacobs, D. K.; Wray, C. G.; Wedeen, C. J.; Kostriken, R.; DeSalle, R.; Staton, J. L.; Gates, R. D.; Lindberg, D. R.

    2000-01-01

    Whether the serial features found in some molluscs are ancestral or derived is considered controversial. Here, in situ hybridization and antibody studies show iterated engrailed-gene expression in transverse rows of ectodermal cells bounding plate field development and spicule formation in the chiton, Lepidochitona cavema, as well as in cells surrounding the valves and in the early development of the shell hinge in the clam, Transennella tantilla. Ectodermal expression of engrailed is associated with skeletogenesis across a range of bilaterian phyla, suggesting a single evolutionary origin of invertebrate skeletons. The shared ancestry of bilaterian-invertebrate skeletons may help explain the sudden appearance of shelly fossils in the Cambrian. Our interpretation departs from the consideration of canonical metameres or segments as units of evolutionary analysis. In this interpretation, the shared ancestry of engrailed-gene function in the terminal/posterior addition of serially repeated elements during development explains the iterative expression of engrailed genes in a range of metazoan body plans.

  16. Working memory capacity and controlled serial memory search.

    PubMed

    Mızrak, Eda; Öztekin, Ilke

    2016-08-01

    The speed-accuracy trade-off (SAT) procedure was used to investigate the relationship between working memory capacity (WMC) and the dynamics of temporal order memory retrieval. High- and low-span participants (HSs, LSs) studied sequentially presented five-item lists, followed by two probes from the study list. Participants indicated the more recent probe. Overall, accuracy was higher for HSs compared to LSs. Crucially, in contrast to previous investigations that observed no impact of WMC on speed of access to item information in memory (e.g., Öztekin & McElree, 2010), recovery of temporal order memory was slower for LSs. While accessing an item's representation in memory can be direct, recovery of relational information such as temporal order information requires a more controlled serial memory search. Collectively, these data indicate that WMC effects are particularly prominent during high demands of cognitive control, such as serial search operations necessary to access temporal order information from memory. PMID:27135712

  17. Fast word reading in pure alexia: "fast, yet serial".

    PubMed

    Bormann, Tobias; Wolfer, Sascha; Hachmann, Wibke; Neubauer, Claudia; Konieczny, Lars

    2015-01-01

    Pure alexia is a severe impairment of word reading in which individuals process letters serially with a pronounced length effect. Yet, there is considerable variation in the performance of alexic readers with generally very slow, but also occasionally fast responses, an observation addressed rarely in previous reports. It has been suggested that "fast" responses in pure alexia reflect residual parallel letter processing or that they may even be subserved by an independent reading system. Four experiments assessed fast and slow reading in a participant (DN) with pure alexia. Two behavioral experiments investigated frequency, neighborhood, and length effects in forced fast reading. Two further experiments measured eye movements when DN was forced to read quickly, or could respond faster because words were easier to process. Taken together, there was little support for the proposal that "qualitatively different" mechanisms or reading strategies underlie both types of responses in DN. Instead, fast responses are argued to be generated by the same serial-reading strategy.

  18. Longitudinal fibre splitting in muscular dystrophy: a serial cinematographic study

    PubMed Central

    Isaacs, Edward R.; Bradley, Walter G.; Henderson, Gerald

    1973-01-01

    A technique of block surface-staining and serial cinematography was modified to review serial sections of normal and dystrophic muscle from the Bar Harbor 129 Re strain of mice as a preliminary study of fibre splitting in dystrophic muscle. Using this technique, muscle fibres were reconstructed for up to 1·5 mm of their length without difficulty. Split fibres were identified only when the actual separation of fibres was observed. Splitting was seen to be a significant cause of the variations in fibre diameter and was at times responsible for the formation of groups of small atrophic fibres which resembled those seen in denervation atrophy. Complex multiple splitting and recombination of daughter and parent fibres was also observed and reconstructed to scale. These results may have considerable significance for the interpretation of physiological data on both human and murine dystrophic muscle. Images PMID:4753877

  19. Serial thyroid iodine content in hyperthyroid patients treated with radioiodine

    SciTech Connect

    Lee, G.S.; Sandler, M.P.; Patton, J.A.; Brill, A.B.

    1986-02-01

    X-ray fluorescent scanning was used to measure initial thyroidal iodine content in 64 patients diagnosed as being hyperthyroid and selected for I-131 therapy, and serially in 48 of these patients after therapy in an attempt to determine those patients that were at high risk of becoming hypothyroid. Iodine content fell rapidly after therapy, reaching a nadir at about three months. Based on the population studied, the chance of early hypothyroidism (within 12 months) is about 80% if the iodine content measured at three months is less than 2 mg. If the iodine content is greater than 2 mg, the chance is only about 14%. The serial measurement of thyroidal iodine content (with x-ray fluorescent scanning) may allow early identification of those patients at high risk of developing permanent hypothyroidism following a therapeutic dose of I-131.

  20. Low-Stroke Actuation for a Serial Robot

    NASA Technical Reports Server (NTRS)

    Gao, Dalong (Inventor); Ihrke, Chris A. (Inventor)

    2014-01-01

    A serial robot includes a base, first and second segments, a proximal joint joining the base to the first segment, and a distal joint. The distal joint that joins the segments is serially arranged and distal with respect to the proximal joint. The robot includes first and second actuators. A first tendon extends from the first actuator to the proximal joint and is selectively moveable via the first actuator. A second tendon extends from the second actuator to the distal joint and is selectively moveable via the second actuator. The robot includes a transmission having at least one gear element which assists rotation of the distal joint when an input force is applied to the proximal and/or distal joints by the first and/or second actuators. A robotic hand having the above robot is also disclosed, as is a robotic system having a torso, arm, and the above-described hand.

  1. Oil-free hyaluronic acid matrix for serial femtosecond crystallography

    PubMed Central

    Sugahara, Michihiro; Song, Changyong; Suzuki, Mamoru; Masuda, Tetsuya; Inoue, Shigeyuki; Nakane, Takanori; Yumoto, Fumiaki; Nango, Eriko; Tanaka, Rie; Tono, Kensuke; Joti, Yasumasa; Kameshima, Takashi; Hatsui, Takaki; Yabashi, Makina; Nureki, Osamu; Numata, Keiji; Iwata, So

    2016-01-01

    The grease matrix was originally introduced as a microcrystal-carrier for serial femtosecond crystallography and has been expanded to applications for various types of proteins, including membrane proteins. However, the grease-based matrix has limited application for oil-sensitive proteins. Here we introduce a grease-free, water-based hyaluronic acid matrix. Applications for proteinase K and lysozyme proteins were able to produce electron density maps at 2.3-Å resolution. PMID:27087008

  2. Which serial killers commit suicide? An exploratory study.

    PubMed

    Lester, David; White, John

    2012-11-30

    In a sample of 483 serial killers, 6.2% were documented to have committed suicide. Those who committed suicide were found to come from more dysfunctional homes characterized by more psychiatric disturbance in the parents. The sexual acts involved in the murders by the suicides seemed to be more deviant in some aspects, such as committing more bizarre sexual acts or more often taping the murder.

  3. Native sulfur/chlorine SAD phasing for serial femtosecond crystallography.

    PubMed

    Nakane, Takanori; Song, Changyong; Suzuki, Mamoru; Nango, Eriko; Kobayashi, Jun; Masuda, Tetsuya; Inoue, Shigeyuki; Mizohata, Eiichi; Nakatsu, Toru; Tanaka, Tomoyuki; Tanaka, Rie; Shimamura, Tatsuro; Tono, Kensuke; Joti, Yasumasa; Kameshima, Takashi; Hatsui, Takaki; Yabashi, Makina; Nureki, Osamu; Iwata, So; Sugahara, Michihiro

    2015-12-01

    Serial femtosecond crystallography (SFX) allows structures to be determined with minimal radiation damage. However, phasing native crystals in SFX is not very common. Here, the structure determination of native lysozyme from single-wavelength anomalous diffraction (SAD) by utilizing the anomalous signal of sulfur and chlorine at a wavelength of 1.77 Å is successfully demonstrated. This sulfur SAD method can be applied to a wide range of proteins, which will improve the determination of native crystal structures.

  4. Native sulfur/chlorine SAD phasing for serial femtosecond crystallography

    PubMed Central

    Nakane, Takanori; Song, Changyong; Suzuki, Mamoru; Nango, Eriko; Kobayashi, Jun; Masuda, Tetsuya; Inoue, Shigeyuki; Mizohata, Eiichi; Nakatsu, Toru; Tanaka, Tomoyuki; Tanaka, Rie; Shimamura, Tatsuro; Tono, Kensuke; Joti, Yasumasa; Kameshima, Takashi; Hatsui, Takaki; Yabashi, Makina; Nureki, Osamu; Iwata, So; Sugahara, Michihiro

    2015-01-01

    Serial femtosecond crystallography (SFX) allows structures to be determined with minimal radiation damage. However, phasing native crystals in SFX is not very common. Here, the structure determination of native lysozyme from single-wavelength anomalous diffraction (SAD) by utilizing the anomalous signal of sulfur and chlorine at a wavelength of 1.77 Å is successfully demonstrated. This sulfur SAD method can be applied to a wide range of proteins, which will improve the determination of native crystal structures. PMID:26627659

  5. A nonparametric trend test for seasonal data with serial dependence.

    USGS Publications Warehouse

    Hirsch, R.M.; Slack, J.R.

    1984-01-01

    Statistical tests for monotonic trend in seasonal (eg monthly) hydrologic time series are commonly confounded by some of the following problems: nonnormal data, missing values, seasonality, censoring and serial dependence. An extension of the Mann-Kendall test for trend (designed for such data) is presented here. Because the test is based entirely on tanks, it is robust against nonnormality and censoring.-from Authors

  6. Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.

    PubMed

    Weierstall, Uwe; James, Daniel; Wang, Chong; White, Thomas A; Wang, Dingjie; Liu, Wei; Spence, John C H; Bruce Doak, R; Nelson, Garrett; Fromme, Petra; Fromme, Raimund; Grotjohann, Ingo; Kupitz, Christopher; Zatsepin, Nadia A; Liu, Haiguang; Basu, Shibom; Wacker, Daniel; Han, Gye Won; Katritch, Vsevolod; Boutet, Sébastien; Messerschmidt, Marc; Williams, Garth J; Koglin, Jason E; Marvin Seibert, M; Klinker, Markus; Gati, Cornelius; Shoeman, Robert L; Barty, Anton; Chapman, Henry N; Kirian, Richard A; Beyerlein, Kenneth R; Stevens, Raymond C; Li, Dianfan; Shah, Syed T A; Howe, Nicole; Caffrey, Martin; Cherezov, Vadim

    2014-01-01

    Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond crystallography. Data collected from sub-10-μm-sized crystals produced with less than 0.5 mg of purified protein yield structural insights regarding cyclopamine binding to the Smoothened receptor.

  7. Two Serial Data to Pulse Code Modulation System Interfaces

    NASA Technical Reports Server (NTRS)

    Hamory, Phil

    2006-01-01

    Two pulse code modulation (PCM) system interfaces for asynchronous serial data are described. One interface is for global positioning system (GPS) data on the NASA Dryden Flight Research Center (DFRC) F-15B (McDonnell Douglas Corporation, St. Louis, Missouri) airplane, tail number 836 (F-15B/836). The other is for flight control computer data on the duPont Aerospace (La Jolla, California) DP-1, a 53-percent scale model of the duPont Aerospace DP-2.

  8. Oil-free hyaluronic acid matrix for serial femtosecond crystallography

    NASA Astrophysics Data System (ADS)

    Sugahara, Michihiro; Song, Changyong; Suzuki, Mamoru; Masuda, Tetsuya; Inoue, Shigeyuki; Nakane, Takanori; Yumoto, Fumiaki; Nango, Eriko; Tanaka, Rie; Tono, Kensuke; Joti, Yasumasa; Kameshima, Takashi; Hatsui, Takaki; Yabashi, Makina; Nureki, Osamu; Numata, Keiji; Iwata, So

    2016-04-01

    The grease matrix was originally introduced as a microcrystal-carrier for serial femtosecond crystallography and has been expanded to applications for various types of proteins, including membrane proteins. However, the grease-based matrix has limited application for oil-sensitive proteins. Here we introduce a grease-free, water-based hyaluronic acid matrix. Applications for proteinase K and lysozyme proteins were able to produce electron density maps at 2.3-Å resolution.

  9. Which serial killers commit suicide? An exploratory study.

    PubMed

    Lester, David; White, John

    2012-11-30

    In a sample of 483 serial killers, 6.2% were documented to have committed suicide. Those who committed suicide were found to come from more dysfunctional homes characterized by more psychiatric disturbance in the parents. The sexual acts involved in the murders by the suicides seemed to be more deviant in some aspects, such as committing more bizarre sexual acts or more often taping the murder. PMID:23131308

  10. Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

    PubMed Central

    Weierstall, Uwe; James, Daniel; Wang, Chong; White, Thomas A.; Wang, Dingjie; Liu, Wei; Spence, John C.H.; Doak, R. Bruce; Nelson, Garrett; Fromme, Petra; Fromme, Raimund; Grotjohann, Ingo; Kupitz, Christopher; Zatsepin, Nadia A.; Liu, Haiguang; Basu, Shibom; Wacker, Daniel; Han, Gye Won; Katritch, Vsevolod; Boutet, Sébastien; Messerschmidt, Marc; Williams, Garth J.; Koglin, Jason E.; Seibert, M. Marvin; Klinker, Markus; Gati, Cornelius; Shoeman, Robert L.; Barty, Anton; Chapman, Henry N.; Kirian, Richard A.; Beyerlein, Kenneth R.; Stevens, Raymond C.; Li, Dianfan; Shah, Syed T.A.; Howe, Nicole; Caffrey, Martin; Cherezov, Vadim

    2014-01-01

    Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously-renewed source of material for serial femtosecond crystallography. Data collected from sub-10 μm-sized crystals produced with less than 0.5 mg of purified protein yield structural insights regarding cyclopamine binding to the Smoothened receptor. PMID:24525480

  11. Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.

    PubMed

    Weierstall, Uwe; James, Daniel; Wang, Chong; White, Thomas A; Wang, Dingjie; Liu, Wei; Spence, John C H; Bruce Doak, R; Nelson, Garrett; Fromme, Petra; Fromme, Raimund; Grotjohann, Ingo; Kupitz, Christopher; Zatsepin, Nadia A; Liu, Haiguang; Basu, Shibom; Wacker, Daniel; Han, Gye Won; Katritch, Vsevolod; Boutet, Sébastien; Messerschmidt, Marc; Williams, Garth J; Koglin, Jason E; Marvin Seibert, M; Klinker, Markus; Gati, Cornelius; Shoeman, Robert L; Barty, Anton; Chapman, Henry N; Kirian, Richard A; Beyerlein, Kenneth R; Stevens, Raymond C; Li, Dianfan; Shah, Syed T A; Howe, Nicole; Caffrey, Martin; Cherezov, Vadim

    2014-01-01

    Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond crystallography. Data collected from sub-10-μm-sized crystals produced with less than 0.5 mg of purified protein yield structural insights regarding cyclopamine binding to the Smoothened receptor. PMID:24525480

  12. Arthrogryposis wrist deformities: results of infantile serial casting.

    PubMed

    Smith, Dean W; Drennan, James C

    2002-01-01

    Arthrogryposis multiplex congenita involving the upper extremity can be associated with significant contractures of major joints. Treatment options to maximize upper extremity motion and function include passive joint stretching, serial casting, or surgical intervention. This study reviewed all patients at Carrie Tingley Hospital with arthrogrypotic wrist flexion contractures treated with passive stretching, serial casting, and custom wrist orthotics to determine the effect on wrist position and function. Seventeen infant patients with distal and classic arthrogryposis used this regimen. Average follow-up was 6 years. The greatest gain in wrist motion occurred after the first casting session for both groups. Patients with distal arthrogryposis had the largest improvement in passive wrist motion, were more functionally independent at final follow-up, and had no recurrence of deformity. Patients with classic arthrogryposis had rigid wrist flexion contractures and a 75% incidence of deformity recurrence after casting. At final follow-up, these patients remained functionally dependent, requiring >50% assistance with activities of daily living, and had less improvement in wrist motion. The authors recommend early casting of infant wrist deformities for both forms of arthrogryposis. If the wrist deformity recurs, repeat serial casting is unlikely to improve wrist extension. Other treatment options may be considered in the older child.

  13. Efficient multitasking: parallel versus serial processing of multiple tasks

    PubMed Central

    Fischer, Rico; Plessow, Franziska

    2015-01-01

    In the context of performance optimizations in multitasking, a central debate has unfolded in multitasking research around whether cognitive processes related to different tasks proceed only sequentially (one at a time), or can operate in parallel (simultaneously). This review features a discussion of theoretical considerations and empirical evidence regarding parallel versus serial task processing in multitasking. In addition, we highlight how methodological differences and theoretical conceptions determine the extent to which parallel processing in multitasking can be detected, to guide their employment in future research. Parallel and serial processing of multiple tasks are not mutually exclusive. Therefore, questions focusing exclusively on either task-processing mode are too simplified. We review empirical evidence and demonstrate that shifting between more parallel and more serial task processing critically depends on the conditions under which multiple tasks are performed. We conclude that efficient multitasking is reflected by the ability of individuals to adjust multitasking performance to environmental demands by flexibly shifting between different processing strategies of multiple task-component scheduling. PMID:26441742

  14. Efficient multitasking: parallel versus serial processing of multiple tasks.

    PubMed

    Fischer, Rico; Plessow, Franziska

    2015-01-01

    In the context of performance optimizations in multitasking, a central debate has unfolded in multitasking research around whether cognitive processes related to different tasks proceed only sequentially (one at a time), or can operate in parallel (simultaneously). This review features a discussion of theoretical considerations and empirical evidence regarding parallel versus serial task processing in multitasking. In addition, we highlight how methodological differences and theoretical conceptions determine the extent to which parallel processing in multitasking can be detected, to guide their employment in future research. Parallel and serial processing of multiple tasks are not mutually exclusive. Therefore, questions focusing exclusively on either task-processing mode are too simplified. We review empirical evidence and demonstrate that shifting between more parallel and more serial task processing critically depends on the conditions under which multiple tasks are performed. We conclude that efficient multitasking is reflected by the ability of individuals to adjust multitasking performance to environmental demands by flexibly shifting between different processing strategies of multiple task-component scheduling. PMID:26441742

  15. Serial extraction: 20 years of follow-up.

    PubMed

    Almeida, Renato Rodrigues de; Almeida, Marcio Rodrigues de; Oltramari-Navarro, Paula Vanessa Pedron; Conti, Ana Cláudia de Castro Ferreira; Navarro, Ricardo de Lima; Souza, Karen Regina Siqueira de

    2012-01-01

    This paper reports a case treated by a serial extraction program at the mixed dentition stage followed by a corrective orthodontic treatment, with a long-term follow-up period. Twenty years after the interceptive treatment, a harmonious face was observed along with treatment stability in the anterior posterior direction, deep overbite (which has been mentioned as a disadvantage of the serial extraction program), and a small relapse of anterior tooth crowding. All these conditions have been regarded as normal occurrences for most orthodontic treatments with a long-term follow-up period. This case report demonstrated that the establishment of a serial extraction protocol determined relevant esthetic changes that afforded an improvement of the patient's self-esteem, with a positive social impact. Furthermore, the low cost of this protocol permits the use of this therapy with underprivileged populations. It is important to emphasize that an early correction of tooth crowding by this protocol does not guarantee stability, but small relapses do not invalidate its accomplishment.

  16. Serial extraction: 20 years of follow-up

    PubMed Central

    de ALMEIDA, Renato Rodrigues; de ALMEIDA, Marcio Rodrigues; OLTRAMARI-NAVARRO, Paula Vanessa Pedron; CONTI, Ana Cláudia de Castro Ferreira; NAVARRO, Ricardo de Lima; de SOUZA, Karen Regina Siqueira

    2012-01-01

    This paper reports a case treated by a serial extraction program at the mixed dentition stage followed by a corrective orthodontic treatment, with a long-term follow-up period. Twenty years after the interceptive treatment, a harmonious face was observed along with treatment stability in the anterior posterior direction, deep overbite (which has been mentioned as a disadvantage of the serial extraction program), and a small relapse of anterior tooth crowding. All these conditions have been regarded as normal occurrences for most orthodontic treatments with a long-term follow-up period. This case report demonstrated that the establishment of a serial extraction protocol determined relevant esthetic changes that afforded an improvement of the patient's self-esteem, with a positive social impact. Furthermore, the low cost of this protocol permits the use of this therapy with underprivileged populations. It is important to emphasize that an early correction of tooth crowding by this protocol does not guarantee stability, but small relapses do not invalidate its accomplishment. PMID:23032213

  17. DDCMP protocol on a DMA serial-line board

    SciTech Connect

    Hunt, D.N.; Kessler, G.C.

    1982-01-01

    The Nuclear Chemistry Division of Lawrence Livermore National Laboratory is in the midst of an upgrade to their radiation counting facility. The result of this upgrade wil be a computer-based data acquisition network, the Nuclear Chemistry Counting Facility Network (NCCF-NET). This network will consist of forty dedicated LSI-11/2 based controllers, ten interactive LSI-11/23 based workstations and a VAX-11/750 central node for data reduction and storage. One of the data acquisition instruments used in this network is a Nuclear Data pulse-height analyzer, the ND66L. This analyzer communicates to a host system over a 9600-baud serial line, using the DDCMP link level protocol. In order to relieve the host computer from the overhead of handling the DDCMP protocol, an in-house designed DMA serial line board was implemented to communicate with the ND66L. The hardware used and its environment will be duscussed along with the design and implementation of the firmware, which implements the serial DDCMP link.

  18. Efficient multitasking: parallel versus serial processing of multiple tasks.

    PubMed

    Fischer, Rico; Plessow, Franziska

    2015-01-01

    In the context of performance optimizations in multitasking, a central debate has unfolded in multitasking research around whether cognitive processes related to different tasks proceed only sequentially (one at a time), or can operate in parallel (simultaneously). This review features a discussion of theoretical considerations and empirical evidence regarding parallel versus serial task processing in multitasking. In addition, we highlight how methodological differences and theoretical conceptions determine the extent to which parallel processing in multitasking can be detected, to guide their employment in future research. Parallel and serial processing of multiple tasks are not mutually exclusive. Therefore, questions focusing exclusively on either task-processing mode are too simplified. We review empirical evidence and demonstrate that shifting between more parallel and more serial task processing critically depends on the conditions under which multiple tasks are performed. We conclude that efficient multitasking is reflected by the ability of individuals to adjust multitasking performance to environmental demands by flexibly shifting between different processing strategies of multiple task-component scheduling.

  19. Voltage balancing strategies for serial connection of microbial fuel cells

    NASA Astrophysics Data System (ADS)

    Khaled, Firas; Ondel, Olivier; Allard, Bruno; Buret, François

    2015-07-01

    The microbial fuel cell (MFC) converts electrochemically organic matter into electricity by means of metabolisms of bacteria. The MFC power output is limited by low voltage and low current characteristics in the range of microwatts or milliwatts per litre. In order to produce a sufficient voltage level (>1.5 V) and sufficient power to supply real applications such as autonomous sensors, it is necessary to either scale-up one single unit or to connect multiple units together. Many topologies of connection are possible as the serial association to improve the output voltage, or the parallel connection to improve the output current or the series/parallel connection to step-up both voltage and current. The association of MFCs in series is a solution to increase the voltage to an acceptable value and to mutualize the unit's output power. The serial association of a large number of MFCs presents several issues. The first one is the hydraulic coupling among MFCs when they share the same substrate. The second one is the dispersion between generators that lead to a non-optimal stack efficiency because the maximum power point (MPP) operation of all MFCs is not permitted. Voltage balancing is a solution to compensate non-uniformities towards MPP. This paper presents solutions to improve the efficiency of a stack of serially connected MFCs through a voltage-balancing circuit. Contribution to the topical issue "Electrical Engineering Symposium (SGE 2014)", edited by Adel Razek

  20. Highly Reliable, High-Speed, Unidirectional Serial Data Links

    NASA Technical Reports Server (NTRS)

    Cole, Robert M.; Bishop, Jamie

    2005-01-01

    Highly reliable, high-speed, unidirectional serial data-communication subsystems have been proposed to be installed in an upgrade of the computing systems aboard the space shuttles. The basic design concept of these serial data links is also adaptable to terrestrial use in applications in which there are requirements for highly reliable serial data communications. The hardware and software aspects of the architecture of the data links are dictated largely by a requirement, in the original space-shuttle application, for one computer to monitor the memory transactions and memory contents of other computers in real time with high reliability and without reliance on requests for retransmission. To minimize weight while affording a capability to transfer data at a required rate of 2.56 x 10(exp 8) bits per second, it was decided that the links would be serial ones of the fiber-channel type. [Fiber channel denotes a type of serial computer bus that is used to connect a computer (usually a supercomputer) with a high-speed data storage device. Depending on the specific application, the physical connection between the transmitter and receiver could be made via an optical fiber or a twisted pair of wires.] Heretofore, fiber-channel links have ordinarily been bidirectional and have operated under protocols that provide for receiving stations to detect errors and request retransmission when necessary. In the present case, the time taken by processing to request retransmission would conflict with the requirement for real-time transfer of data. To ensure reliability without retransmission, a link according to the proposal would utilize a modified version of the normal fiberchannel character set in conjunction with forward error correction by means of a Reed-Solomon code (see figure). The Reed-Solomon encoding and decoding and the translations between the normal and modified character sets would be effected by logic circuitry external to the fiber-channel transmitter and receiver

  1. Serial position memory in the visual-spatial domain: reconstructing sequences of unfamiliar faces.

    PubMed

    Smyth, Mary M; Hay, Dennis C; Hitch, Graham J; Horton, Neil J

    2005-07-01

    In two studies we presented pictures of unfamiliar faces one at a time, then presented the complete set at test and asked for serial reconstruction of the order of presentation. Serial position functions were similar to those found with verbal materials, with considerable primacy and one item recency, position errors that were mainly to the adjacent serial position, a visual similarity effect, and effects of articulatory suppression that did not interact with the serial position effect or with the similarity effect. Serial position effects were found when faces had been seen for as little as 300 ms and after a 6-s retention interval filled with articulatory suppression. Serial position effects found with unfamiliar faces are not based on verbal encoding strategies, and important elements of serial memory may be general across modalities.

  2. Yb9+xCuMg4-x (x = 0.034): A κ-Phase Formed by Lanthanoids.

    PubMed

    De Negri, Serena; Romaka, Vitaliy; Solokha, Pavlo; Saccone, Adriana; Giester, Gerald; Michor, Herwig; Rogl, Peter F

    2016-08-15

    Atom order in the crystal structures of Yb2Cu2-xMg (x = 0.17; Mo2FeB2-type; P4/mbm; a = 0.75592(2) nm; c = 0.40282(1) nm) and Yb9+xCuMg4-x (x = 0.034; Hf9Mo4B-type; P63/mmc; a = 1.0169(5) nm; c = 1.0290(5) nm) was determined from powder and X-ray single-crystal counter data analyses supported by electron probe microanalyses. Among the group of the so-called κ-phases, Yb9+xCuMg4-x is the first representative formed by a lanthanoid element. The structure of this κ-phase can be viewed as a typical network of corner-connected empty Yb6-octahedra, which encompass Yb6Mg6-icosahedra (filled by a mix of Mg/Yb atoms) and Yb6-trigonal prisms centered by Cu atoms to complete the three-dimensional metal framework. From another point of view, the same structure is considered as built from infinite polyicosahedral columns of Yb9Mg4 composition with Cu atoms located in trigonal prismatic interstices, highlighting similarities with other Yb-rich Yb-Cu-Mg phases. Density functional theory (DFT) calculations classify Yb9CuMg4 as a polar intermetallic. Metallic-like behavior is inferred from the Sommerfeld constant, γ = 49.2 mJ/mol·K(2), derived from the electronic density of states, calculated at the Fermi level. DFT integration of the f-density of states indicates almost completely filled f-states, revealing 13.6 and 13.7 electrons in the valence band for Yb1 and Yb2 atoms, respectively, close to the Yb(2+) ground state ((1)S0) for both Yb atoms. Magnetic susceptibility data recorded on the same compound are consistent with a nonmagnetic divalent Yb(2+) state. Temperature-dependent heat capacity data display a metallic behavior characterized by a small Sommerfeld constant γ = 64.8 mJ/mol·K(2) and a rather low Debye temperature ΘD = 140 K as typical for soft materials. PMID:27463217

  3. Synthesis and Thermoelectric Properties of La1- z Yb z Fe4- x Ni x Sb12 Skutterudites

    NASA Astrophysics Data System (ADS)

    Jeon, Bong-Jun; Shin, Dong-Kil; Kim, Il-Ho

    2016-03-01

    p-Type La1- z Yb z Fe4- x Ni x Sb12 (0.25 ≤ z ≤ 0.75 and 0.25 ≤ x ≤ 0.5) skutterudites were prepared by encapsulated melting and hot pressing, and the effects of filling and substitution (charge compensation) on the transport and thermoelectric properties were examined. The single-phase skutterudite was successfully synthesized through La/Yb double filling and Ni substitution for Fe. However, a small amount of FeSb2 was detected for La0.25Yb0.75Fe3.75 Ni0.25Sb12, which was attributed to insufficient charge compensation due to deficiency of substitution of Ni for Fe, as well as higher filling fraction of Yb with lower valence than La. The carrier concentration and electrical conductivity decreased with increasing La and Ni contents, with La serving to provide more excess electrons and Ni mediating charge compensation. The electrical conductivity decreased with increasing temperature, indicating that La1- z Yb z Fe4- x Ni x Sb12 skutterudites were degenerate semiconductors. The positive values of the Hall coefficient and the Seebeck coefficient meant that the major carriers were holes with p-type conduction. The Seebeck coefficient increased with increasing temperature, showing peak values ranging from 723 K to 823 K, which increased with increasing La and Ni contents. The maximum power factor of 2.9 mW m-1 K-2 was obtained for La0.75Yb0.25 Fe3.75Ni0.25Sb12. The thermal conductivity increased at temperatures above 623 K due to bipolar conduction, and the lattice thermal conductivity decreased with increasing filling fraction of Yb, indicating that the Yb filling was more effective at reducing the lattice thermal conductivity than the La filling. The electronic thermal conductivity decreased with increasing La and Ni contents due to the decrease in the carrier concentration. The dimensionless figure of merit ( ZT) showed peak values at 723 K, attributed to the decreased Seebeck coefficient (or power factor) and the increased thermal conductivity due to bipolar

  4. Periodicity, Electronic Structures, and Bonding of Gold Tetrahalides [AuX4]- (X = F, Cl, Br, I, At, Uus).

    PubMed

    Li, Wan-Lu; Li, Yong; Xu, Cong-Qiao; Wang, Xue-Bin; Vorpagel, Erich; Li, Jun

    2015-12-01

    Systematic theoretical and experimental investigations have been performed to understand the periodicity, electronic structures, and bonding of gold halides using tetrahalide [AuX4](-) anions (X = F, Cl, Br, I, At, Uus). The [AuX4](-) (X = Cl, Br, I) anions were experimentally produced in the gas phase, and their negative-ion photoelectron spectra were obtained, exhibiting rich and well-resolved spectral peaks. As expected, Au-X bonds in such series contain generally increasing covalency when halogen ligands become heavier. We calculated the adiabatic electron detachment energies as well as vertical electron detachment energies using density functional theory methods with scalar relativistic and spin-orbit coupling effects. The computationally simulated photoelectron spectra are in good agreement with the experimental ones. Our results show that the trivalent Au(III) oxidation state becomes progressively less stable while Au(I) tends to be preferred when the halides become heavier along the Periodic Table. This series of molecules provides an example for manipulating the oxidation state of metals in complexes through ligand design. PMID:26550845

  5. Interplay between crystal field splitting and Kondo effect in CeNi9Ge(4-x)Si(x).

    PubMed

    Gold, C; Gross, P; Peyker, L; Eickerling, G; Simeoni, G G; Stockert, O; Kampert, E; Wolff-Fabris, F; Michor, H; Scheidt, E-W

    2012-09-01

    The pseudo-ternary solid solution CeNi(9)Ge(4-x)Si(x) (0 ≤ x ≤ 4) has been investigated by means of x-ray diffraction, magnetic susceptibility, specific heat, electrical resistivity, thermopower and inelastic neutron scattering studies. The isoelectronic substitution of germanium by silicon atoms causes a dramatic change of the relative strength of competing Kondo, RKKY and crystal field (CF) energy scales. The strongest effect is the continuous elevation of the Kondo temperature T(K) from approximately 3.5 K for CeNi(9)Ge(4) to about 70 K for CeNi(9)Si(4). This increase of the Kondo temperature is attended by a change of the CF level scheme of the Ce ions. The interplay of the different energy scales results in an incipient reduction of the ground state degeneracy from an effectively fourfold degenerate non-magnetic Kondo ground state with unusual non-Fermi-liquid features of CeNi(9)Ge(4) to a lower one, followed by an increase towards a sixfold, fully degenerate ground state multiplet in CeNi(9)Si(4) (T(K) ∼ Δ(CF)).

  6. Growth of Pb nanowires on the Si(111)-In (4x1) a combined STM and SPALEED study

    NASA Astrophysics Data System (ADS)

    Hupalo, Myron; Yakes, Michael; Tringides, Michael

    2006-03-01

    Due to the combined effect of QSE and the anisotropic strain potential of the substrate, Pb deposited on Si(111)-In (4x1) at 180K grows in nanowires of uniform 4-layer height and controllable uniform width of 5w0 { (}where w0=1.33nm is the width of the reconstruction unit cell along [1&_slash;1&_slash;2] direction). SPA-LEED studies confirm this selected 4-layer height (from Intensity vs Kz variation) which is unusually stable because it is unchanged even after annealing to room temperature. The same selected 4-layer height is observed on a different interface Si(111)-In √ 31x√ 31 which independently confirms the unusual 4-layer stability. Differences in the observed corrugation on the tops of the nanowires due to the Moir'{e} pattern at the metal/semiconductor interface confirm the strain anisotropy on the reconstructed substrate. Further Pb deposition on top of the nanowires results in the completion of the Pb layer with unusually atomically flat film interfaces over mesoscopic distances.

  7. Filled Co (sub X) Ni (sub 4-x) Sb (sub 12-y) Sn (sub Y) Skutterudites: Processing and Thermoelectric Properties

    NASA Technical Reports Server (NTRS)

    Mackey, Jon; Sehirlioglu, Alp; Dynys, Fred

    2015-01-01

    Skutterudites have proven to be a useful thermoelectric system as a result of their enhanced figure of merit (ZT1), cheap material cost, favorable mechanical properties, and good thermal stability. The majority of skutterudite interest in recent years has been focused on binary skutterudites like CoSb3 or CoAs3. Binary skutterudites are often double and triple filled, with a range of elements from the lanthanide series, in order to reduce the lattice component of thermal conductivity. Ternary and quaternary skutterudites, such as Co4Ge6Se6 or Ni4Sb8Sn4, provide additional paths to tune the electronic structure. The thermal conductivity can further be improved in these complex skutterudites by the introduction of fillers. The Co (sub X) Ni (sub 4-x) Sb (sub 12-y) Sn (sub Y) system has been investigated as both a p- and n-type thermoelectric material, and is stable up to 200 degrees Centigrade. Yb, Ce, and Dy fillers have been introduced into the skutterudite to study the influence of both the type and the quantity of fillers on processing conditions and thermoelectric properties. The system was processed through a multi-step technique that includes solidification, mechano-chemical alloying, and hot pressing which will be discussed along with thermoelectric transport properties.

  8. Co(x)Ni(4-x)Sb(12-y)Sn(y) Ternary Skutterudites: Processing and Thermoelectric Properties

    NASA Technical Reports Server (NTRS)

    Mackey, Jon; Sehirlioglu, Alp; Dynys, Fred

    2014-01-01

    Skutterudites have proven to be a useful thermoelectric system as a result of their high figure of merit, favorable mechanical properties, and good thermal stability. Binary skutterudites have received the majority of interest in recent years, as a result of successful double and triple filling schemes. Ternary skutterudites, such as Ni4Sb7Sn5, also demonstrate good thermoelectric performance, with high power factor and low thermal conductivity. Ternary skutterudites, as contrasted to binary systems, provide more possibility for tuning electronic structure as substitutions can be studied on three elements. The Co(x)Ni(4-x)Sb(12-y)Sn(y) system has been investigated as both a p- and n-type thermoelectric material, stable up to 200 C. The system is processed through a combination of solidification, mechanical alloying, and hot pressing steps. Rietveld structure refinement has revealed an interesting occupancy of Sn on both the 24g Wyckoff position with Sb as well as the 2a position as a rattler. In addition to thermoelectric properties, detailed processing routes have been investigated on the system.

  9. Synthesis and Thermoelectric Properties of Ce1-z Pr z Fe4-x Co x Sb12 Skutterudites

    NASA Astrophysics Data System (ADS)

    Song, Kwon-Min; Shin, Dong-Kil; Jang, Kyung-Wook; Choi, Soon-Mok; Lee, Soonil; Seo, Won-Seon; Kim, Il-Ho

    2016-08-01

    p-Type Ce1-z Pr z Fe4-x Co x Sb12 skutterudites were prepared by encapsulated melting, quenching, annealing, and hot pressing. While the skutterudite phase was successfully synthesized, a small amount of the secondary phase (FeSb2) was observed. According to the scanning electron microscope analysis, (Ce,Pr)Sb2 phases were also observed for Co-substituted specimens (x = 0.5). The electrical conductivity decreased with increasing temperature, implying a degenerate semiconductor behavior, and also decreased with increasing Co contents. All specimens showed p-type characteristics having positive signs of the Hall coefficient and the Seebeck coefficient. The Seebeck coefficient increased with increasing temperature and reached a maximum value at 823 K. The power factor (PF) increased with decreasing Co content and Ce0.75Pr0.25 Fe4Sb12 showed a peak value of PF = 3.2 mW m-1 K-2 at 823 K. The electronic thermal conductivity decreased with increasing Co contents and the lattice thermal conductivity decreased with decreasing Ce and Co contents at high temperature. The thermal conductivity increased at temperatures above 623 K due to bipolar conduction. The dimensionless figure␣of merit (ZT) showed a maximum value of ZT = 0.84 at 823 K for Ce0.25Pr0.75Fe4Sb12.

  10. Electronic Band Structure, Optical, Thermal and Bonding Properties of XMg2O4(X = Si, Ge) Spinel Compounds

    NASA Astrophysics Data System (ADS)

    Semari, F.; Ouahrani, T.; Khachai, H.; Khenata, R.; Rabah, M.; Bouhemadou, A.; Murtaza, G.; Amin, B.; Rached, D.

    2013-07-01

    Bonding nature as well as structural, optoelectronic and thermal properties of the cubic XMg2O4(X = Si, Ge) spinel compounds have been calculated using a full-potential augmented plane-wave plus local orbitals (FP-APW+lo) method within the density functional theory. The exchange-correlation potential was treated with the PBE-GGA approximation to calculate the total energy. Moreover, the modified Becke-Johnson potential (TB-mBJ) was also applied to improve the electronic band structure calculations. The computed ground-state parameters (a, B, B‧ and u) are in excellent agreements with the available theoretical data. Calculations of the electronic band structure and bonding properties show that these compounds have a direct energy band gap (Γ-Γ) with a dominated ionic character and the TB-mBJ approximation yields larger fundamental band gaps compared to those obtained using the PBE-GGA. Optical properties such as the complex dielectric function ɛ(ω), reflectivity R(ω) and energy loss function L(ω), for incident photon energy up to 40 eV, have been predicted. Through the quasi-harmonic Debye model, in which the phononic effects are considered, the effects of pressure P and temperature T on the thermal expansion coefficient, Debye temperature and heat capacity for the considered compounds are investigated for the first time.

  11. Irradiation of 4''x4'' NaI(Tl) detector by the 14 MeV neutrons.

    PubMed

    Sudac, D; Valkovic, V

    2010-01-01

    Within the EURopean Illicit TRAfficking Countermeasures Kit (EURITRACK) project, a new Tagged Neutron Inspection System (TNIS) has been developed and installed in the Port of Rijeka in Croatia. The system was based on the examination of sea containers with the 14 MeV neutron beam. During the operation the characteristic gamma rays were produced and measured by several 5''x5''x10'' NaI(Tl) detectors. During this procedure some of the detectors were exposed to an intensive neutron beam radiation. It was necessary to check for possible radiation damage of the NaI(Tl) scintillator during the gamma detector selection phase of the project. The 4''x4'' NaI(Tl) detector was exposed to 14 MeV neutrons for 20 h. From the presented results on energy resolution and activation measurements it could be concluded that there are no significant differences in energy resolution before and after the irradiation by 4.7x10(11) of 14 MeV neutrons. The only problem could be the high level of medium and long term induced activity in the energy region below 2 MeV.

  12. All-optical 4x10 Gbps NAND gate using single mode Fabry-Pérot laser diode.

    PubMed

    Nakarmi, B; Zhang, X; Won, Y H

    2015-10-19

    We demonstrate all-optical 4x10 Gbps NAND gate with an individual input data rate of 10 Gbps using single mode Fabry-Pérot laser diode. The proposed scheme is based on the principle of multi-input injection locking. All-optical NAND gate is one of the universal logic gates which can be used for realizing all other logic gates for optical communication and networks. The output performance of the proposed all-optical multi-input NAND gate is verified with output spectrum domain results, waveforms, rising-falling time, and eye diagram measurement at 10 Gbps input. The ON/OFF contrast ratio of 41 dB is measured at the spectrum domain output when all four input beams are logic high. In all other combinations of four inputs, maximum ON/OFF contrast ratio of 1.5 dB ON/OFF is measured. Clear output waveform, output eye diagram with an extinction ratio of about 11 dB, and rising-falling time of about 35 ps are obtained. The BER measurement is carried out and we found the power penalty of about 1.7 dB at BER of 10(-9).

  13. Structural stability and electronic property of C68X4 (X=H, F, and Cl) fullerene compounds.

    PubMed

    Tang, Shu-Wei; Feng, Jing-Dong; Sun, Li-Li; Wang, Feng-Di; Sun, Hao; Chang, Ying-Fei; Wang, Rong-Shun

    2010-06-01

    A systematic study on the geometrical structures and electronic properties of C(68)X(4) (X=H, F, and Cl) fullerene compounds has been carried out on the basis of density functional theory. In all classical C(68)X(4) isomers with two adjacent pentagons and one quasifullerene isomer [C(s):C(68)(f)] containing a heptagon in the framework, the C(s):0064 isomers are most favorable in energy. The addition reaction energies of C(68)X(4) (C(s):0064) are high exothermic, and C(68)F(4) is more thermodynamically accessible. The C(68)X(4) (C(s):0064) possess strong aromatic character, with nucleus independent chemical shifts ranging from -22.0 to -26.1 ppm. Further investigations on electronic properties indicate that C(68)F(4) and C(68)Cl(4) could be excellent electron-acceptors for potential photonic/photovoltaic applications in consequence of their large vertical electron affinities (3.29 and 3.15 eV, respectively). The Mulliken charge populations and partial density of states are also calculated, which show that decorating C(68) fullerene with various X atoms will cause remarkably different charge distributions in C(68)X(4) (C(s):0064) and affect their electronic properties distinctly. Finally, the infrared spectra of the most stable C(68)X(4) (C(s):0064) molecules are simulated to assist further experimental characterization.

  14. Design and performance of 4 x 5120-element visible and 2 x 2560-element shortwave infrared multispectral focal planes

    NASA Technical Reports Server (NTRS)

    Tower, J. R.; Cope, A. D.; Pellon, L. E.; Mccarthy, B. M.; Strong, R. T.

    1986-01-01

    Two solid-state sensors for use in remote sensing instruments operating in the pushbroom mode are examined. The design and characteristics of the visible/near-infrared (VIS/NIR) device and the short-wavelength infrared (SWIR) device are described. The VIS/NIR is a CCD imager with four parallel sensor lines, each 1024 pixel long; the chip design and filter system of the VIS/NIR are studied. The performance of the VIS/NIR sensor with mask and its system performance are measured. The SWIR is a dual-band line imager consisting of palladium silicide Schottky-barrier detectors coupled to CCD multiplexers; the performance of the device is analyzed. The substrate materials and layout designs used to assemble the 4 x 5120-element VIS/NIR array and the 2 x 2560-element SWIR array are discussed, and the planarity of the butted arrays are verified using a profilometer. The optical and electrical characteristics, and the placement and butting accuracy of the arrays are evaluated. It is noted that the arrays met or exceed their expected performance.

  15. Subunit sequences of the 4 x 6-mer hemocyanin from the golden orb-web spider, Nephila inaurata.

    PubMed

    Averdam, Anne; Markl, Jürgen; Burmester, Thorsten

    2003-08-01

    The transport of oxygen in the hemolymph of many arthropod and mollusc species is mediated by large copper-proteins that are referred to as hemocyanins. Arthropod hemocyanins are composed of hexamers and oligomers of hexamers. Arachnid hemocyanins usually form 4 x 6-mers consisting of seven distinct subunit types (termed a-g), although in some spider taxa deviations from this standard scheme have been observed. Applying immunological and electrophoretic methods, six distinct hemocyanin subunits were identified in the red-legged golden orb-web spider Nephila inaurata madagascariensis (Araneae: Tetragnathidae). The complete cDNA sequences of six subunits were obtained that corresponded to a-, b-, d-, e-, f- and g-type subunits. No evidence for a c-type subunit was found in this species. The inclusion of the N. inaurata hemocyanins in a multiple alignment of the arthropod hemocyanins and the application of the Bayesian method of phylogenetic inference allow, for the first time, a solid reconstruction of the intramolecular evolution of the chelicerate hemocyanin subunits. The branch leading to subunit a diverged first, followed by the common branch of the dimer-forming b and c subunits, while subunits d and f, as well as subunits e and g form common branches. Assuming a clock-like evolution of the chelicerate hemocyanins, a timescale for the evolution of the Chelicerata was obtained that agrees with the fossil record.

  16. High temperature phase stabilities and electrochemical properties of InBaCo4-xZnxO7 cathodes for intermediate temperature solid oxide fuel cells

    SciTech Connect

    Kim, Jung-Hyun; Young Nam, Kim; Bi, Zhonghe; Manthiram, Arumugam; Paranthaman, Mariappan Parans; Huq, Ashfia

    2011-01-01

    InBaCo4-xZnxO7 oxides have been synthesized and characterized as cathode materials for intermediate temperature solid oxide fuel cells (IT-SOFC). The effect of Zn substitution for Co on the structure, phase stability, thermal expansion, and electrochemical properties of the InBaCo4-xZnxO7 has been investigated. The increase in the Zn content from x = 1 to 1.5 improves the high temperature phase stability at 600 oC and 700 oC for 100 h, and chemical stability against a Gd0.2Ce0.8O1.9 (GDC) electrolyte. Thermal expansion coefficient (TEC) values of the InBaCo4-xZnxO7 (x = 1, 1.5, 2) specimens were determined to be 8.6 10-6 9.6 10-6 /oC in the range of 80 900 oC, which provides good thermal expansion compatibility with the standard SOFC electrolyte materials. The InBaCo4-xZnxO7 + GDC (50:50 wt. %) composite cathodes exhibit improved cathode performances compared to those obtained from the simple InBaCo4-xZnxO7 cathodes due to the extended triple-phase boundary (TPB) and enhanced oxide-ion conductivity through the GDC portion in the composites.

  17. Can serial scintigraphic studies detect delayed fracture union in man

    SciTech Connect

    O'Reilly, R.J.; Cook, D.J.; Gaffney, R.D.; Angel, K.R.; Paterson, D.C.

    1981-01-01

    The uptake of the bone-seeking tracer technetium-99m-methylenediphosphonate increases following bone fracture as bone healing occurs. To investigate the pattern of change in normal healing and compare it with delayed union and nonunion, an analysis of automated computer profiles was carried out on serial scan data for 22 patients. The type of fracture (simple, comminuted, etc.) influenced the appearance of the activity profile; however, no significant differences in the patterns of change were noted between normal healing and delayed or non-union.

  18. Hi-speed versatile serial crate controller for CAMAC

    SciTech Connect

    Horelick, D.

    1984-10-01

    A serial crate controller, primarily for use in the SLC CAMAC control system, has been designed, and has been in use for about 2 years. The design supports a party line approach, with up to 16 crates on a single twisted pair for data transfers, plus another pair for prompt L response. The bit rate is 5 megabits/s, and complete transaction times of about 10 ..mu..s are achieved for 16-bit data transfers over cables up to 1000 feet long. One of the primary objects of the design was simplicity - there are approximately 60 chips in the two-board unit.

  19. Controllable optomechanical coupling in serially-coupled triple resonators

    SciTech Connect

    Huang, Chenguang Zhao, Yunsong; Fan, Jiahua; Zhu, Lin

    2014-12-15

    Radiation pressure can efficiently couple mechanical modes with optical modes in an optical cavity. The coupling efficiency is quite dependent on the interaction between the optical mode and mechanical mode. In this report, we investigate a serially-coupled triple resonator system, where a freestanding beam is placed in the vicinity of the middle resonator. In this coupled system, we demonstrate that the mechanical mode of the free-standing beam can be selectively coupled to different resonance supermodes through the near field interaction.

  20. Serial femtosecond X-ray diffraction of enveloped virus microcrystals

    DOE PAGESBeta

    Lawrence, Robert M.; Conrad, Chelsie E.; Zatsepin, Nadia A.; Grant, Thomas D.; Liu, Haiguang; James, Daniel; Nelson, Garrett; Subramanian, Ganesh; Aquila, Andrew; Hunter, Mark S.; et al

    2015-08-20

    Serial femtosecond crystallography (SFX) using X-ray free-electron lasers has produced high-resolution, room temperature, time-resolved protein structures. We report preliminary SFX of Sindbis virus, an enveloped icosahedral RNA virus with ~700 Å diameter. Microcrystals delivered in viscous agarose medium diffracted to ~40 Å resolution. Small-angle diffuse X-ray scattering overlaid Bragg peaks and analysis suggests this results from molecular transforms of individual particles. Viral proteins undergo structural changes during entry and infection, which could, in principle, be studied with SFX. This is a pertinent step toward determining room temperature structures from virus microcrystals that may enable time-resolved studies of enveloped viruses.

  1. Protein crystal screening and characterization for serial femtosecond nanocrystallography

    PubMed Central

    Darmanin, Connie; Strachan, Jamie; Adda, Christopher G.; Ve, Thomas; Kobe, Bostjan; Abbey, Brian

    2016-01-01

    The recent development of X-ray free electron lasers (XFELs) has spurred the development of serial femtosecond nanocrystallography (SFX) which, for the first time, is enabling structure retrieval from sub-micron protein crystals. Although there are already a growing number of structures published using SFX, the technology is still very new and presents a number of unique challenges as well as opportunities for structural biologists. One of the biggest barriers to the success of SFX experiments is the preparation and selection of suitable protein crystal samples. Here we outline a protocol for preparing and screening for suitable XFEL targets. PMID:27139248

  2. Occupational therapy articles in serial publications: an analysis of sources.

    PubMed Central

    Reed, K L

    1988-01-01

    This study was designed to locate and document serial literature on occupational therapy published since 1900. Emphasis is placed on finding articles on occupational therapy or by occupational therapists from sources other than those normally associated with the professional journals. Multiple sources were used including print indexes, online databases, occupational therapy bibliographies, and tables of contents or yearly indexes. Almost 7,000 articles were identified, not including those published in foreign journals. Occupational therapy publications have increased steadily since 1900, with the most rapid increase during the 1970s and 1980s when five new occupational therapy journals were initiated. Suggestions for formulating search strategies are included. PMID:3285932

  3. High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography

    PubMed Central

    Boutet, Sébastien; Lomb, Lukas; Williams, Garth J.; Barends, Thomas R. M.; Aquila, Andrew; Doak, R. Bruce; Weierstall, Uwe; DePonte, Daniel P.; Steinbrener, Jan; Shoeman, Robert L.; Messerschmidt, Marc; Barty, Anton; White, Thomas A.; Kassemeyer, Stephan; Kirian, Richard A.; Seibert, M. Marvin; Montanez, Paul A.; Kenney, Chris; Herbst, Ryan; Hart, Philip; Pines, Jack; Haller, Gunther; Gruner, Sol M.; Philipp, Hugh T.; Tate, Mark W.; Hromalik, Marianne; Koerner, Lucas J.; van Bakel, Niels; Morse, John; Ghonsalves, Wilfred; Arnlund, David; Bogan, Michael J.; Caleman, Carl; Fromme, Raimund; Hampton, Christina Y.; Hunter, Mark S.; Johansson, Linda C.; Katona, Gergely; Kupitz, Christopher; Liang, Mengning; Martin, Andrew V.; Nass, Karol; Redecke, Lars; Stellato, Francesco; Timneanu, Nicusor; Wang, Dingjie; Zatsepin, Nadia A.; Schafer, Donald; Defever, James; Neutze, Richard; Fromme, Petra; Spence, John C. H.; Chapman, Henry N.; Schlichting, Ilme

    2013-01-01

    Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding radiation damage. We applied serial femtosecond crystallography (SFX) using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals (less than 1 micrometer by 1 micrometer by 3 micrometers) of the well-characterized model protein lysozyme. The agreement with synchrotron data demonstrates the immediate relevance of SFX for analyzing the structure of the large group of difficult-to-crystallize molecules. PMID:22653729

  4. High-resolution protein structure determination by serial femtosecond crystallography.

    PubMed

    Boutet, Sébastien; Lomb, Lukas; Williams, Garth J; Barends, Thomas R M; Aquila, Andrew; Doak, R Bruce; Weierstall, Uwe; DePonte, Daniel P; Steinbrener, Jan; Shoeman, Robert L; Messerschmidt, Marc; Barty, Anton; White, Thomas A; Kassemeyer, Stephan; Kirian, Richard A; Seibert, M Marvin; Montanez, Paul A; Kenney, Chris; Herbst, Ryan; Hart, Philip; Pines, Jack; Haller, Gunther; Gruner, Sol M; Philipp, Hugh T; Tate, Mark W; Hromalik, Marianne; Koerner, Lucas J; van Bakel, Niels; Morse, John; Ghonsalves, Wilfred; Arnlund, David; Bogan, Michael J; Caleman, Carl; Fromme, Raimund; Hampton, Christina Y; Hunter, Mark S; Johansson, Linda C; Katona, Gergely; Kupitz, Christopher; Liang, Mengning; Martin, Andrew V; Nass, Karol; Redecke, Lars; Stellato, Francesco; Timneanu, Nicusor; Wang, Dingjie; Zatsepin, Nadia A; Schafer, Donald; Defever, James; Neutze, Richard; Fromme, Petra; Spence, John C H; Chapman, Henry N; Schlichting, Ilme

    2012-07-20

    Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding radiation damage. We applied serial femtosecond crystallography (SFX) using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals (less than 1 micrometer by 1 micrometer by 3 micrometers) of the well-characterized model protein lysozyme. The agreement with synchrotron data demonstrates the immediate relevance of SFX for analyzing the structure of the large group of difficult-to-crystallize molecules.

  5. High-resolution protein structure determination by serial femtosecond crystallography.

    PubMed

    Boutet, Sébastien; Lomb, Lukas; Williams, Garth J; Barends, Thomas R M; Aquila, Andrew; Doak, R Bruce; Weierstall, Uwe; DePonte, Daniel P; Steinbrener, Jan; Shoeman, Robert L; Messerschmidt, Marc; Barty, Anton; White, Thomas A; Kassemeyer, Stephan; Kirian, Richard A; Seibert, M Marvin; Montanez, Paul A; Kenney, Chris; Herbst, Ryan; Hart, Philip; Pines, Jack; Haller, Gunther; Gruner, Sol M; Philipp, Hugh T; Tate, Mark W; Hromalik, Marianne; Koerner, Lucas J; van Bakel, Niels; Morse, John; Ghonsalves, Wilfred; Arnlund, David; Bogan, Michael J; Caleman, Carl; Fromme, Raimund; Hampton, Christina Y; Hunter, Mark S; Johansson, Linda C; Katona, Gergely; Kupitz, Christopher; Liang, Mengning; Martin, Andrew V; Nass, Karol; Redecke, Lars; Stellato, Francesco; Timneanu, Nicusor; Wang, Dingjie; Zatsepin, Nadia A; Schafer, Donald; Defever, James; Neutze, Richard; Fromme, Petra; Spence, John C H; Chapman, Henry N; Schlichting, Ilme

    2012-07-20

    Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding radiation damage. We applied serial femtosecond crystallography (SFX) using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals (less than 1 micrometer by 1 micrometer by 3 micrometers) of the well-characterized model protein lysozyme. The agreement with synchrotron data demonstrates the immediate relevance of SFX for analyzing the structure of the large group of difficult-to-crystallize molecules. PMID:22653729

  6. A semiautomated approach for artefact removal in serial tissue cryosections.

    PubMed

    Kindle, L M; Kakadiaris, I A; Ju, T; Carson, J P

    2011-02-01

    Thinly sliced serial tissue sections of an organ can be imaged using optical microscopy at a resolution detailing individual cells. When the tissue sections are first subjected to in situ hybridization or immunohistochemistry, these data sets can be analysed for changes in gene expression and gene products. Such spatial information is important for understanding the functional effects of experimental or environmental challenges to the organism. However, a critical step in analysing these data sets is mitigating artefacts that result from the preparation of the tissue sections. In this paper, we describe an automated method with manual validation tools that together enable detecting and addressing artefacts including dust particles and air bubbles. PMID:21118219

  7. Vertical comb-drive microscanner with 4x4 array of micromirrors for phase-shifting Mirau microinterferometry

    NASA Astrophysics Data System (ADS)

    Bargiel, Sylwester; Lullin, Justine; Lemoal, Patrice; Perrin, Stéphane; Passilly, Nicolas; Albero, Jorge; Froehly, Luc; Lardet-Vieudrin, Franck; Gorecki, Christophe

    2016-04-01

    In this paper, we present construction, fabrication and characterization of an electrostatic MOEMS vertical microscanner for generation of an optical phase shift in array-type interferometric microsystems. The microscanner employs asymmetric comb-drives for a vertical displacement of a large 4x4 array of reference micromirrors and for in-situ position sensing. The device is designed to be fully compatible with Mirau configuration and with vertical integration strategy. This enables further integration of the device within an "active" multi-channel Mirau micro-interferometer and implementation of the phase shifting interferometry (PSI) technique for imaging applications. The combination of micro-interferometer and PSI is particularly interesting in the swept-source optical coherence tomography, since it allows not only strong size reduction of a system but also improvement of its performance (sensitivity, removal of the image artefacts). The technology of device is based on double-side DRIE of SOI wafer and vapor HF releasing of the suspended platform. In the static mode, the device provides vertical displacement of micromirrors up to 2.8μm (0 - 40V), whereas at resonance (fo=500 Hz), it reaches 0.7 μm for only 1VDC+1VAC. In both operation modes, the measured displacement is much more than required for PSI implementation (352nm peak-to-peak). The presented device is a key component of array-type Mirau micro-interferometer that enables the construction of portable, low-cost interferometric systems, e.g. for in vivo medical diagnostics.

  8. Transfer to changed serial position in a task of tracking a sequence of light stimuli.

    PubMed

    Inui, N

    1996-06-01

    This study examined transfer when different serial positions are changed in a task of tracking a sequence of light stimuli. Thirty subjects were divided into three groups, and all tracked a serial pattern of six movements for 20 acquisition trials. Then, on 20 more transfer trials, the last two movements were reversed for Group I, the second two movements reversed for Group II, and the first two movements reversed for the Group III. Performance during the transfer trials improved over performance during the acquisition trials for Groups I and II but not Group III. Thus, there appeared to be positive transfer when the last and middle parts of the serial pattern were changed. However, there was no positive transfer when the first part of the serial pattern was changed. This indicated a contextual interference effect dependent upon serial position in the performance of a serial tracking task.

  9. Auditory word serial recall benefits from orthographic dissimilarity.

    PubMed

    Pattamadilok, Chotiga; Lafontaine, Hélène; Morais, José; Kolinsky, Régine

    2010-01-01

    The influence of orthographic knowledge has been consistently observed in dissimilarity speech recognition and metaphonological tasks. The present study provides data suggesting that such influence also pervades other cognitive domains phonological related to language abilities, such as verbal working memory. Using serial similarity effect recall of auditory seven-word lists, we observed that inter-item orthographic dissimilarity assists verbal working memory by reducing or even avoiding verbal serial recall the detrimental effect of phonological similarity. However, this orthographic modulation of the phonological similarity effect only occurred at positions four to six of the word list. Performance at position seven benefited from a recency effect that may be assumed to result from a more surface-level (acoustic-phonetic) representation, while better performance at positions one to three is attributable to primacy effects, and can be accounted for in terms of consolidation through recapitulation. The beneficial influence of orthographic knowledge may, therefore, only be apparent when the item stored in short-term memory takes the form of an abstract but unconsolidated phonological representation.

  10. Distinctiveness and serial position effects in tonal sequences.

    PubMed

    Surprenant, A M

    2001-05-01

    The proportion-of-the-total-duration rule (Kidd & Watson, 1992) states that the detectability of a change in a component of a tonal sequence can be predicted by the proportional duration of the changed component relative to the length of the sequence as a whole. A similar viewpoint relies on temporal distinctiveness to account for primacy, recency, and other serial position effects in memory (Murdock, 1960; Neath, 1993a, 1993b). Such distinctiveness models predict that an item will be remembered if it is more distinctive along some dimension relative to possible competitors. Three experiments explored the relation between distinctiveness and proportional duration by examining the effects of the proportion of the total duration of a tone in a sequence, serial position, and interstimulus interval (ISI) on the detection of a change in one component of a tonal sequence. Experiment 1 replicated the basic effect with relatively untrained subjects and a fixed frequency difference. Experiment 2 showed that distinctiveness holds for tonal sequences and a same/different task. Experiment 3 combined the two to show that proportional duration, ISI, and position of the changed tone all contribute to discrimination performance. The present research combines theories that have been proposed in the psychophysics and memory fields and suggests that a comprehensive principle based on relative distinctiveness may be able to account for both perceptual and memory effects.

  11. Forgetting in immediate serial recall: decay, temporal distinctiveness, or interference?

    PubMed

    Oberauer, Klaus; Lewandowsky, Stephan

    2008-07-01

    Three hypotheses of forgetting from immediate memory were tested: time-based decay, decreasing temporal distinctiveness, and interference. The hypotheses were represented by 3 models of serial recall: the primacy model, the SIMPLE (scale-independent memory, perception, and learning) model, and the SOB (serial order in a box) model, respectively. The models were fit to 2 experiments investigating the effect of filled delays between items at encoding or at recall. Short delays between items, filled with articulatory suppression, led to massive impairment of memory relative to a no-delay baseline. Extending the delays had little additional effect, suggesting that the passage of time alone does not cause forgetting. Adding a choice reaction task in the delay periods to block attention-based rehearsal did not change these results. The interference-based SOB fit the data best; the primacy model overpredicted the effect of lengthening delays, and SIMPLE was unable to explain the effect of delays at encoding. The authors conclude that purely temporal views of forgetting are inadequate.

  12. Determinants of phrasing effects in rat serial pattern learning.

    PubMed

    Wallace, Douglas G; Rowan, James D; Fountain, Stephen B

    2008-04-01

    Two experiments investigated how brief pauses introduced into serial patterns as phrasing cues would affect pattern learning in rats. In Experiment 1, a 24-element pattern consisted of eight 3-element chunks, whereas a 20-element pattern consisted of four 5-element chunks. In both patterns, 3.0-s temporal pauses placed at chunk boundaries (synchronous phrasing cues) facilitated learning compared to no phrasing. Cues "out of sync" with pattern structure (asynchronous phrasing cues) facilitated learning for the 24-element pattern and retarded learning for the 20-element pattern. Evidence suggested that in the latter case, 3.0-s pauses served as "blank" trials that induced rats to "skip" to the next serial position in sequence. In Experiment 2, shorter 0.5-s pauses served as phrasing cues in the 20-element pattern of Experiment 1. Synchronous short cues facilitated learning, whereas asynchronous phrasing cues had no effect. Furthermore, removal of synchronous cues produced deficits in performance on formerly cued trials, whereas removal of asynchronous cues had no effect. The results of Experiment 2 support the notion that in both experiments phrasing cues served as discriminative cues and indirectly suggest that rats are concurrently sensitive to pattern element cues, extra-sequence cues (such as phrasing cues), and to the relative timing of sequential events.

  13. Serial femtosecond crystallography: A revolution in structural biology.

    PubMed

    Martin-Garcia, Jose M; Conrad, Chelsie E; Coe, Jesse; Roy-Chowdhury, Shatabdi; Fromme, Petra

    2016-07-15

    Macromolecular crystallography at synchrotron sources has proven to be the most influential method within structural biology, producing thousands of structures since its inception. While its utility has been instrumental in progressing our knowledge of structures of molecules, it suffers from limitations such as the need for large, well-diffracting crystals, and radiation damage that can hamper native structural determination. The recent advent of X-ray free electron lasers (XFELs) and their implementation in the emerging field of serial femtosecond crystallography (SFX) has given rise to a remarkable expansion upon existing crystallographic constraints, allowing structural biologists access to previously restricted scientific territory. SFX relies on exceptionally brilliant, micro-focused X-ray pulses, which are femtoseconds in duration, to probe nano/micrometer sized crystals in a serial fashion. This results in data sets comprised of individual snapshots, each capturing Bragg diffraction of single crystals in random orientations prior to their subsequent destruction. Thus structural elucidation while avoiding radiation damage, even at room temperature, can now be achieved. This emerging field has cultivated new methods for nanocrystallogenesis, sample delivery, and data processing. Opportunities and challenges within SFX are reviewed herein.

  14. Human thermoregulatory responses during serial cold-water immersions.

    PubMed

    Castellani, J W; Young, A J; Sawka, M N; Pandolf, K B

    1998-07-01

    This study examined whether serial cold-water immersions over a 10-h period would lead to fatigue of shivering and vasoconstriction. Eight men were immersed (2 h) in 20 degrees C water three times (0700, 1100, and 1500) in 1 day (Repeat). This trial was compared with single immersions (Control) conducted at the same times of day. Before Repeat exposures at 1100 and 1500, rewarming was employed to standardize initial rectal temperature. The following observations were made in the Repeat relative to the Control trial: 1) rectal temperature was lower and heat debt was higher (P < 0.05) at 1100; 2) metabolic heat production was lower (P < 0.05) at 1100 and 1500; 3) subjects perceived the Repeat trial as warmer at 1100. These data suggest that repeated cold exposures may impair the ability to maintain normal body temperature because of a blunting of metabolic heat production, perhaps reflecting a fatigue mechanism. An alternative explanation is that shivering habituation develops rapidly during serially repeated cold exposures. PMID:9655776

  15. Rethinking Conceptual Definitions of the Criminal Career and Serial Criminality.

    PubMed

    Edelstein, Arnon

    2016-01-01

    Since Cesare Lombroso's days, criminology seeks to define, explain, and categorize the various types of criminals, their behaviors, and motives. This aim has theoretical as well as policy-related implications. One of the important areas in criminological thinking focuses chiefly on recidivist offenders who perform large numbers of crimes and/or commit the most dangerous crimes in society (rape, murder, arson, and armed robbery). These criminals have been defined as "habitual offenders," "professional criminals," "career criminals," and "serial offenders." The interest in these criminals is a rational one, given the perception that they present a severe threat to society. The main challenge in this area of research is a conceptual problem that has significant effects across the field. To this day, scholars have reused and misused titles to define and explain different concepts. The aim of this article is 3-fold. First, to review the concepts of criminal career, professional crime, habitual offenses, and seriality with a critical attitude on confusing terms. Second, to propose the redefinition of concepts mentioned previously, mainly on the criminal career. Third, to propose a theoretical model to enable a better understanding of, and serve as a basis for, further research in this important area of criminology.

  16. Serial Determinations of Blood Lactate in Respiratory Distress Syndrome

    PubMed Central

    Beca, J. P.; Scopes, J. W.

    1972-01-01

    Blood lactate was measured 4-hourly in 21 newborn babies with respiratory distress syndrome, of whom 13 survived and 8 died. In general, lactate levels were higher in babies who died than in survivors, but there were inconsistencies which were uninterpretable if only a single estimation were made in a baby. Analysis of serial determinations showed that all patients in whom the lactate level never exceeded 35 mg/100 ml survived, and babies with high but falling values also did well. Only those who had rising lactate values, even if initially normal, died. In most cases a high or normal Pao2 was associated with normal or decreasing lactate level; but babies with Pao2 below 60 mmHg had often also normal or decreasing lactate levels. Some babies had high and increasing lactate levels despite having normal Pao2. In order to use lactate levels for prognosis in respiratory distress syndrome (RDS) serial determinations are required. It is concluded that there may be a wide range of hypoxaemia without oxygen deficit in body tissues, so that it is not possible to define a `lower acceptable Pao2' which will define adequate tissue oxygenation. PMID:5046772

  17. Forgetting in immediate serial recall: decay, temporal distinctiveness, or interference?

    PubMed

    Oberauer, Klaus; Lewandowsky, Stephan

    2008-07-01

    Three hypotheses of forgetting from immediate memory were tested: time-based decay, decreasing temporal distinctiveness, and interference. The hypotheses were represented by 3 models of serial recall: the primacy model, the SIMPLE (scale-independent memory, perception, and learning) model, and the SOB (serial order in a box) model, respectively. The models were fit to 2 experiments investigating the effect of filled delays between items at encoding or at recall. Short delays between items, filled with articulatory suppression, led to massive impairment of memory relative to a no-delay baseline. Extending the delays had little additional effect, suggesting that the passage of time alone does not cause forgetting. Adding a choice reaction task in the delay periods to block attention-based rehearsal did not change these results. The interference-based SOB fit the data best; the primacy model overpredicted the effect of lengthening delays, and SIMPLE was unable to explain the effect of delays at encoding. The authors conclude that purely temporal views of forgetting are inadequate. PMID:18729591

  18. Random-effects models for serial observations with binary response

    SciTech Connect

    Stiratelli, R.; Laird, N.; Ware, J.H.

    1984-12-01

    This paper presents a general mixed model for the analysis of serial dichotomous responses provided by a panel of study participants. Each subject's serial responses are assumed to arise from a logistic model, but with regression coefficients that vary between subjects. The logistic regression parameters are assumed to be normally distributed in the population. Inference is based upon maximum likelihood estimation of fixed effects and variance components, and empirical Bayes estimation of random effects. Exact solutions are analytically and computationally infeasible, but an approximation based on the mode of the posterior distribution of the random parameters is proposed, and is implemented by means of the EM algorithm. This approximate method is compared with a simpler two-step method proposed by Korn and Whittemore, using data from a panel study of asthmatics originally described in that paper. One advantage of the estimation strategy described here is the ability to use all of the data, including that from subjects with insufficient data to permit fitting of a separate logistic regression model, as required by the Korn and Whittemore method. However, the new method is computationally intensive.

  19. Semantic contribution to verbal short-term memory: are pleasant words easier to remember than neutral words in serial recall and serial recognition?

    PubMed

    Monnier, Catherine; Syssau, Arielle

    2008-01-01

    In the four experiments reported here, we examined the role of word pleasantness on immediate serial recall and immediate serial recognition. In Experiment 1, we compared verbal serial recall of pleasant and neutral words, using a limited set of items. In Experiment 2, we replicated Experiment 1 with an open set of words (i.e., new items were used on every trial). In Experiments 3 and 4, we assessed immediate serial recognition of pleasant and neutral words, using item sets from Experiments 1 and 2. Pleasantness was found to have a facilitation effect on both immediate serial recall and immediate serial recognition. This study supplies some new supporting arguments in favor of a semantic contribution to verbal short-term memory performance. The pleasantness effect observed in immediate serial recognition showed that, contrary to a number of earlier findings, performance on this task can also turn out to be dependent on semantic factors. The results are discussed in relation to nonlinguistic and psycholinguistic models of short-term memory.

  20. New developments in electron microscopy for serial image acquisition of neuronal profiles.

    PubMed

    Kubota, Yoshiyuki

    2015-02-01

    Recent developments in electron microscopy largely automate the continuous acquisition of serial electron micrographs (EMGs), previously achieved by laborious manual serial ultrathin sectioning using an ultramicrotome and ultrastructural image capture process with transmission electron microscopy. The new systems cut thin sections and capture serial EMGs automatically, allowing for acquisition of large data sets in a reasonably short time. The new methods are focused ion beam/scanning electron microscopy, ultramicrotome/serial block-face scanning electron microscopy, automated tape-collection ultramicrotome/scanning electron microscopy and transmission electron microscope camera array. In this review, their positive and negative aspects are discussed.

  1. Management of serial ECGs and control strategies for the comparison process.

    PubMed

    Fayn, J; Rubel, P; Willems, J L

    1994-03-01

    Serial ECG management and control of the comparison process should be dynamically driven by patient data. The functional architecture requirements are specified for a computerized ECG processing system integrating serial analysis. The concepts of reference investigations and temporal events are first explained. A conceptual reference model is proposed which stratifies the serial analysis process into a few generic strategies which will be instantiated into several types of serial comparison processing tasks as a function of the clinical evolution of the patient. This model is an extension of the OEDIPE core data model developed and implemented during the AIM #2026 project.

  2. Serial agonistic attacks by greylag goose families, Anser anser, against the same opponent

    PubMed Central

    Scheiber, Isabella B.R.; Kotrschal, Kurt; Weiß, Brigitte M.

    2011-01-01

    It is known from primates that alliance partners may support each other’s interests in competition with others, for example, through repeated agonistic attacks against a particular individual. We examined serial aggressive interactions between greylag goose families and other flock members. We found that repeated attacks towards the same individual were common and that up to five serial attacks by family members followed an initial attack. Family size did not affect the frequency of such serial attacks. Juvenile geese evidently benefited most from active social support through serial attacks. About 60% of the juveniles’ lost primary interactions were subsequently reversed by another family member. This may be one of the reasons why juveniles rank higher in the social hierarchy than would be expected from their age and size alone. Losses in serial attacks predominantly occurred against other, presumably higher-ranking, family geese and ganders. We propose three major functions/consequences of serial attacks. Analogous to primates, serial attacks in greylag geese may serve to reinforce a losing experience of an opponent defeated in a preceding attack. On the side of the winning family, serial attacks may reinforce the experience of winning. Both winning and losing experiences are linked with physiological consequences in higher vertebrates, affecting the future social performance of winners or losers. Finally, serial attacks may signal the agonistic potential of a family to other flock members. This is supported by heart rate data, which indicate that greylags are competent to interpret third-party relationships. PMID:21984838

  3. New developments in electron microscopy for serial image acquisition of neuronal profiles.

    PubMed

    Kubota, Yoshiyuki

    2015-02-01

    Recent developments in electron microscopy largely automate the continuous acquisition of serial electron micrographs (EMGs), previously achieved by laborious manual serial ultrathin sectioning using an ultramicrotome and ultrastructural image capture process with transmission electron microscopy. The new systems cut thin sections and capture serial EMGs automatically, allowing for acquisition of large data sets in a reasonably short time. The new methods are focused ion beam/scanning electron microscopy, ultramicrotome/serial block-face scanning electron microscopy, automated tape-collection ultramicrotome/scanning electron microscopy and transmission electron microscope camera array. In this review, their positive and negative aspects are discussed. PMID:25564566

  4. An Existence Proof: Successful Joint Implementation of the IMP Curriculum and a 4 x 4 Block Schedule at a Suburban U.S. High School

    ERIC Educational Resources Information Center

    Kramer, Steven L.; Keller, Regina

    2008-01-01

    This "Brief Report" summarizes results from a study that investigated joint effects of two innovations adopted at a high school in an affluent suburban community in the northeast United States: 4 x 4 block scheduling and the "Standards"-based curriculum, the Interactive Mathematics Program (IMP).

  5. The role of ion pairs in the second-order NLO response of 4-X-1-methylpiridinium salts.

    PubMed

    Tessore, Francesca; Cariati, Elena; Cariati, Franco; Roberto, Dominique; Ugo, Renato; Mussini, Patrizia; Zuccaccia, Cristiano; Macchioni, Alceo

    2010-02-01

    A series of 4-X-1-methylpyridinium cationic nonlinear optical (NLO) chromophores (X = (E)-CH=CHC(6)H(5); (E)-CH=CHC(6)H(4)-4'-C(CH(3))(3); (E)-CH=CHC(6)H(4)-4'-N(CH(3))(2); (E)-CH=CHC(6)H(4)-4'-N(C(4)H(9))(2); (E,E)-(CH=CH)(2)C(6)H(4)-4'-N(CH(3))(2)) with various organic (CF(3)SO(3)(-), p-CH(3)C(6)H(4)SO(3)(-)), inorganic (I(-), ClO(4)(-), SCN(-), [Hg(2)I(6)](2-)) and organometallic (cis-[Ir(CO)(2)I(2)](-)) counter anions are studied with the aim of investigating the role of ion pairing and of ionic dissociation or aggregation of ion pairs in controlling their second-order NLO response in anhydrous chloroform solution. The combined use of electronic absorption spectra, conductimetric measurements and pulsed field gradient spin echo (PGSE) NMR experiments show that the second-order NLO response, investigated by the electric-field-induced second harmonic generation (EFISH) technique, of the salts of the cationic NLO chromophores strongly depends upon the nature of the counter anion and concentration. The ion pairs are the major species at concentration around 10(-3) M, and their dipole moments were determined. Generally, below 5x10(-4) M, ion pairs start to dissociate into ions with parallel increase of the second-order NLO response, due to the increased concentration of purely cationic NLO chromophores with improved NLO response. At concentration higher than 10(-3) M, some multipolar aggregates, probably of H type, are formed, with parallel slight decrease of the second-order NLO response. Ion pairing is dependent upon the nature of the counter anion and on the electronic structure of the cationic NLO chromophore. It is very strong for the thiocyanate anion in particular and, albeit to a lesser extent, for the sulfonated anions. The latter show increased tendency to self-aggregate.

  6. Canine bone blood flow measurements using serial microsphere injections.

    PubMed

    McGrory, B J; Moran, C G; Bronk, J; Weaver, A L; Wood, M B

    1994-06-01

    The objective of this study was to determine the reproducibility of serial bone blood flow (BBF) quantitation using multiple microsphere injections. Three consecutive estimates of BBF were obtained, using 15-mu radionuclide-labeled microspheres from 21 anesthetized adult dogs. A dose of 3 million spheres/kg was used in seven dogs (Cohort 1); a dose of 0.5 million spheres/kg was used in the remaining 14 dogs (Cohorts 2 and 3). Estimates of BBF were made at an average of 129, 153, and 175 minutes after the animals had been anesthetized in the first two cohorts and 179, 203, and 225 minutes in Cohort 3. The dogs in Cohort 1 had no surgical intervention; the dogs in Cohorts 2 and 3 had increasingly complex surgical interventions. Despite stabilization of cardiovascular status, BBF was found to vary by 33.4% in Cohort 1, 25.7% in Cohort 2, and 42.5% in Cohort 3 over the three injections. Cortical BBF fell by 13.9%, 12.1%, and 12.4% between the first and second, and by 31.0%, 11.2%, and 29.9% between the second and third estimates for Cohorts 1, 2, and 3, respectively. Variation in right to left blood flow was used as an overall measure of error caused by technique and did not consistently increase between the first, second, or third BBF estimates in any cohort. Cortical BBF data were found to be significantly more reliable than cancellous data (p < 0.01); error caused by technique was least in the midshaft femoral or midshaft humeral cortical samples. Increasing the dose of spheres administered from 0.5 to 3 million/kg for three serial microsphere injections increased the number of reliable samples and did not lead to increased technical error or shunting. This study demonstrates that there is a significant decrease in BBF over time in the anesthetized dog; therefore, serial estimates of BBF can only be interpreted if the results are normalized or if a control group of animals is included.

  7. Rhythmic expression of cytochrome P450 epoxygenases CYP4x1 and CYP2c11 in the rat brain and vasculature.

    PubMed

    Carver, Koryn A; Lourim, David; Tryba, Andrew K; Harder, David R

    2014-12-01

    Mammals have circadian variation in blood pressure, heart rate, vascular tone, thrombotic tendency, and cerebral blood flow (CBF). These changes may be in part orchestrated by circadian variation in clock gene expression within cells comprising the vasculature that modulate blood flow (e.g., fibroblasts, cerebral vascular smooth muscle cells, astrocytes, and endothelial cells). However, the downstream mechanisms that underlie circadian changes in blood flow are unknown. Cytochrome P450 epoxygenases (Cyp4x1 and Cyp2c11) are expressed in the brain and vasculature and metabolize arachidonic acid (AA) to form epoxyeicosatrienoic acids (EETs). EETs are released from astrocytes, neurons, and vascular endothelial cells and act as potent vasodilators, increasing blood flow. EETs released in response to increases in neural activity evoke a corresponding increase in blood flow known as the functional hyperemic response. We examine the hypothesis that Cyp2c11 and Cyp4x1 expression and EETs production vary in a circadian manner in the rat brain and cerebral vasculature. RT-PCR revealed circadian/diurnal expression of clock and clock-controlled genes as well as Cyp4x1 and Cyp2c11, within the rat hippocampus, middle cerebral artery, inferior vena cava, hippocampal astrocytes and rat brain microvascular endothelial cells. Astrocyte and endothelial cell culture experiments revealed rhythmic variation in Cyp4x1 and Cyp2c11 gene and protein expression with a 12-h period and parallel rhythmic production of EETs. Our data suggest there is circadian regulation of Cyp4x1 and Cyp2c11 gene expression. Such rhythmic EETs production may contribute to circadian changes in blood flow and alter risk of adverse cardiovascular events throughout the day.

  8. Examining the relationship between free recall and immediate serial recall: the serial nature of recall and the effect of test expectancy.

    PubMed

    Bhatarah, Parveen; Ward, Geoff; Tan, Lydia

    2008-01-01

    In two experiments, we examined the relationship between free recall and immediate serial recall (ISR), using a within-subjects (Experiment 1) and a between-subjects (Experiment 2) design. In both experiments, participants read aloud lists of eight words and were precued or postcued to respond using free recall or ISR. The serial position curves were U-shaped for free recall and showed extended primacy effects with little or no recency for ISR, and there was little or no difference between recall for the precued and the postcued conditions. Critically, analyses of the output order showed that although the participants started their recall from different list positions in the two tasks, the degree to which subsequent recall was serial in a forward order was strikingly similar. We argue that recalling in a serial forward order is a general characteristic of memory and that performance on ISR and free recall is underpinned by common memory mechanisms.

  9. The primacy model: a new model of immediate serial recall.

    PubMed

    Page, M P; Norris, D

    1998-10-01

    A new model of immediate serial recall is presented: the primacy model. The primacy model stores order information by means of the assumption that the strength of activation of successive list items decreases across list position to form a primacy gradient. Ordered recall is supported by a repeated cycle of operations involving a noisy choice of the most active item followed by suppression of the chosen item. Word-length and list-length effects are attributed to a decay process that occurs both during input, when effective rehearsal is prevented, and during output. The phonological similarity effect is attributed to a second stage of processing at which phonological confusions occur. The primacy model produces accurate simulations of the effects of word length, list length, and phonological similarity.

  10. Serial position functions for recognition of olfactory stimuli.

    PubMed

    Johnson, Andrew J; Miles, Christopher

    2007-10-01

    Two experiments examined item recognition memory for sequentially presented odours. Following a sequence of six odours participants were immediately presented with a series of two-alternative forced-choice (2AFC) test odours. The test pairs were presented in either the same order as learning or the reverse order of learning. Method of testing was either blocked (Experiment 1) or mixed (Experiment 2). Both experiments demonstrated extended recency, with an absence of primacy, for the reverse testing procedure. In contrast, the forward testing procedure revealed a null effect of serial position. The finding of extended recency is inconsistent with the single-item recency predicted by the two-component duplex theory (Phillips & Christie, 1977). We offer an alternative account of the data in which recognition accuracy is better accommodated by the cumulative number of items presented between item learning and item test.

  11. Immediate serial recall, word frequency, item identity and item position.

    PubMed

    Poirier, M; Saint-Aubin, J

    1996-12-01

    Eighteen subjects completed an immediate serial recall task, where the to-be-recalled lists consisted of either high, medium, or low-frequency items. Moreover, lists were either phonologically similar or distinct. Results showed that increasing frequency enhanced item information recall but had no effect on order recall. Conversely, increasing phonological similarity had a detrimental effect on order recall but no significant effect on item recall. It is argued that both effects reflect retrieval processes where degraded representations are reconstructed on the basis of long-term knowledge: Low-frequency words have reduced accessibility, lowering the probability of correct reconstruction, and phonologically similar items are more easily confused with other recall candidates.

  12. Closed-Loop Analysis of Soft Decisions for Serial Links

    NASA Technical Reports Server (NTRS)

    Lansdowne, Chatwin A.; Steele, Glen F.; Zucha, Joan P.; Schlensinger, Adam M.

    2012-01-01

    Modern receivers are providing soft decision symbol synchronization as radio links are challenged to push more data and more overhead through noisier channels, and software-defined radios use error-correction techniques that approach Shannon s theoretical limit of performance. The authors describe the benefit of closed-loop measurements for a receiver when paired with a counterpart transmitter and representative channel conditions. We also describe a real-time Soft Decision Analyzer (SDA) implementation for closed-loop measurements on single- or dual- (orthogonal) channel serial data communication links. The analyzer has been used to identify, quantify, and prioritize contributors to implementation loss in real-time during the development of software defined radios.

  13. Closed-Loop Analysis of Soft Decisions for Serial Links

    NASA Technical Reports Server (NTRS)

    Lansdowne, Chatwin A.; Steele, Glen F.; Zucha, Joan P.; Schlesinger, Adam M.

    2013-01-01

    We describe the benefit of using closed-loop measurements for a radio receiver paired with a counterpart transmitter. We show that real-time analysis of the soft decision output of a receiver can provide rich and relevant insight far beyond the traditional hard-decision bit error rate (BER) test statistic. We describe a Soft Decision Analyzer (SDA) implementation for closed-loop measurements on single- or dual- (orthogonal) channel serial data communication links. The analyzer has been used to identify, quantify, and prioritize contributors to implementation loss in live-time during the development of software defined radios. This test technique gains importance as modern receivers are providing soft decision symbol synchronization as radio links are challenged to push more data and more protocol overhead through noisier channels, and software-defined radios (SDRs) use error-correction codes that approach Shannon's theoretical limit of performance.

  14. Liquid sample delivery techniques for serial femtosecond crystallography

    PubMed Central

    Weierstall, Uwe

    2014-01-01

    X-ray free-electron lasers overcome the problem of radiation damage in protein crystallography and allow structure determination from micro- and nanocrystals at room temperature. To ensure that consecutive X-ray pulses do not probe previously exposed crystals, the sample needs to be replaced with the X-ray repetition rate, which ranges from 120 Hz at warm linac-based free-electron lasers to 1 MHz at superconducting linacs. Liquid injectors are therefore an essential part of a serial femtosecond crystallography experiment at an X-ray free-electron laser. Here, we compare different techniques of injecting microcrystals in solution into the pulsed X-ray beam in vacuum. Sample waste due to mismatch of the liquid flow rate to the X-ray repetition rate can be addressed through various techniques. PMID:24914163

  15. Serial haemostatic monitoring of dogs with multicentric lymphoma.

    PubMed

    Kol, A; Marks, S L; Skorupski, K A; Kass, P H; Guerrero, T; Gosselin, R C; Borjesson, D L

    2015-09-01

    Lymphoma is the most common haematopoietic malignancy in dogs and it has been associated with hypercoagulability and subsequent thromboembolism. The objectives of this study were to serially characterize the haemostatic status of dogs with multicentric lymphoma. Thromboelastography, thrombin-antithrombin complex concentration and routine haematology and coagulation panels were measured. Twenty-seven dogs were included in the study and 15 completed the study in remission. At presentation, 81% (22/27) of dogs with multicentric lymphoma had altered haemostatic profiles consistent with hypercoagulability. Laboratory evidence of hypercoagulability did not resolve during treatment or for up to 1 month following attainment of clinical remission. Accelerated rate of clot formation at the time of chemotherapeutic protocol completion was associated with decreased survival time. We concluded that dogs with multicentric lymphoma were frequently hypercoagulable from presentation through 4 weeks after the completion of chemotherapy. Increased angle and shortened K in dogs that have successfully completed their chemotherapeutic protocol may be associated with shorter survival times.

  16. Dispersion serial dilution methods using the gradient diluter device.

    PubMed

    Walling, Leslie; Schulz, Craig; Johnson, Michael

    2012-12-01

    A solute aspirated into a prefilled tube of diluent undergoes a dilution effect known as dispersion. Traditionally the effects of dispersion have been considered a negative consequence of using liquid-filled fixed-tip liquid handlers. We present a novel device and technique that utilizes the effects of dispersion to the benefit of making dilutions. The device known as the Gradient Diluter extends the dilution range of practical serial dilutions to six orders of magnitude in final volumes as low as 10 μL. Presented are the device, dispersion methods, and validation tests using fluorescence detection of sulforhodamine and the high-performance liquid chromatography/ultraviolet detection of furosemide. In addition, a T-cell inhibition assay of a relevant downstream protein is used to demonstrate IC(50) curves made with the Gradient Diluter compare favorably with those generated by hand.

  17. Data processing pipeline for serial femtosecond crystallography at SACLA1

    PubMed Central

    Nakane, Takanori; Joti, Yasumasa; Tono, Kensuke; Yabashi, Makina; Nango, Eriko; Iwata, So; Ishitani, Ryuichiro; Nureki, Osamu

    2016-01-01

    A data processing pipeline for serial femtosecond crystallography at SACLA was developed, based on Cheetah [Barty et al. (2014). J. Appl. Cryst.47, 1118–1131] and CrystFEL [White et al. (2016). J. Appl. Cryst.49, 680–689]. The original programs were adapted for data acquisition through the SACLA API, thread and inter-node parallelization, and efficient image handling. The pipeline consists of two stages: The first, online stage can analyse all images in real time, with a latency of less than a few seconds, to provide feedback on hit rate and detector saturation. The second, offline stage converts hit images into HDF5 files and runs CrystFEL for indexing and integration. The size of the filtered compressed output is comparable to that of a synchrotron data set. The pipeline enables real-time feedback and rapid structure solution during beamtime. PMID:27275146

  18. Whole Brain Imaging with Serial Two-Photon Tomography

    PubMed Central

    Amato, Stephen P.; Pan, Feng; Schwartz, Joel; Ragan, Timothy M.

    2016-01-01

    Imaging entire mouse brains at submicron resolution has historically been a challenging undertaking and largely confined to the province of dedicated atlasing initiatives. This has limited systematic investigations into important areas of neuroscience, such as neural circuits, brain mapping and neurodegeneration. In this article, we describe in detail Serial Two-Photon (STP) tomography, a robust, reliable method for imaging entire brains with histological detail. We provide examples of how the basic methodology can be extended to other imaging modalities, such as Optical Coherence Tomography (OCT), in order to provide unique contrast mechanisms. Furthermore, we provide a survey of the research that STP tomography has enabled in the field of neuroscience, provide examples of how this technology enables quantitative whole brain studies, and discuss the current limitations of STP tomography-based approaches. PMID:27047350

  19. Serial analysis of gene expression (SAGE) in rat liver regeneration

    SciTech Connect

    Cimica, Velasco . E-mail: vcimica@aecom.yu.edu; Batusic, Danko; Haralanova-Ilieva, Borislava; Chen, Yonglong; Hollemann, Thomas; Pieler, Tomas; Ramadori, Giuliano

    2007-08-31

    We have applied serial analysis of gene expression for studying the molecular mechanism of the rat liver regeneration in the model of 70% partial hepatectomy. We generated three SAGE libraries from a normal control liver (NL library: 52,343 tags), from a sham control operated liver (Sham library: 51,028 tags), and from a regenerating liver (PH library: 53,061 tags). By SAGE bioinformatics analysis we identified 40 induced genes and 20 repressed genes during the liver regeneration. We verified temporal expression of such genes by real time PCR during the regeneration process and we characterized 13 induced genes and 3 repressed genes. We found connective tissue growth factor transcript and protein induced very early at 4 h after PH operation before hepatocytes proliferation is triggered. Our study suggests CTGF as a growth factor signaling mediator that could be involved directly in the mechanism of liver regeneration induction.

  20. Statistical design for a small serial dilution series.

    PubMed

    Zelterman, Daniel; Tulupyev, Alexander; Heimer, Robert; Abdala, Nadia

    2010-02-10

    We describe statistical plans for a serial dilution series designed to detect and estimate the number of viral particles in a solution. The design addresses a problem when a very limited number of aliquots are available for proliferation. A gamma prior distribution on the number of viral particles allows us to describe the marginal probability distribution of all experimental outcomes. We examine a design that minimizes the expected reciprocal information and compare this with the maximum entropy design. We argue that the maximum entropy design is more useful from the point of view of the laboratory technician. The problem and design are motivated by our study of the viability of human immunodeficiency virus in syringes and other equipment that might mediate blood-borne viral transmission.

  1. Serial interactome capture of the human cell nucleus.

    PubMed

    Conrad, Thomas; Albrecht, Anne-Susann; de Melo Costa, Veronica Rodrigues; Sauer, Sascha; Meierhofer, David; Ørom, Ulf Andersson

    2016-04-04

    Novel RNA-guided cellular functions are paralleled by an increasing number of RNA-binding proteins (RBPs). Here we present 'serial RNA interactome capture' (serIC), a multiple purification procedure of ultraviolet-crosslinked poly(A)-RNA-protein complexes that enables global RBP detection with high specificity. We apply serIC to the nuclei of proliferating K562 cells to obtain the first human nuclear RNA interactome. The domain composition of the 382 identified nuclear RBPs markedly differs from previous IC experiments, including few factors without known RNA-binding domains that are in good agreement with computationally predicted RNA binding. serIC extends the number of DNA-RNA-binding proteins (DRBPs), and reveals a network of RBPs involved in p53 signalling and double-strand break repair. serIC is an effective tool to couple global RBP capture with additional selection or labelling steps for specific detection of highly purified RBPs.

  2. Serial femtosecond crystallography of soluble proteins in lipidic cubic phase

    SciTech Connect

    Fromme, Raimund; Ishchenko, Andrii; Metz, Markus; Chowdhury, Shatabdi Roy; Basu, Shibom; Boutet, Sébastien; Fromme, Petra; White, Thomas A.; Barty, Anton; Spence, John C. H.; Weierstall, Uwe; Liu, Wei; Cherezov, Vadim

    2015-08-04

    Serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs) enables high-resolution protein structure determination using micrometre-sized crystals at room temperature with minimal effects from radiation damage. SFX requires a steady supply of microcrystals intersecting the XFEL beam at random orientations. An LCP–SFX method has recently been introduced in which microcrystals of membrane proteins are grown and delivered for SFX data collection inside a gel-like membrane-mimetic matrix, known as lipidic cubic phase (LCP), using a special LCP microextrusion injector. Here, it is shown enabling a dramatic reduction in the amount of crystallized protein required for data collection compared with crystals delivered by liquid injectors. High-quality LCP–SFX data sets were collected for two soluble proteins, lysozyme and phycocyanin, using less than 0.1 mg of each protein.

  3. Does the identification of simple features require serial processing?

    NASA Technical Reports Server (NTRS)

    Folk, C. L.; Egeth, H.

    1989-01-01

    Several recent studies have shown performance decrements with increasing display size when background texture elements are present in a same-different feature discrimination task--a result that challenges the traditional notion that the identities of simple visual features are processed in parallel, preattentively. Four experiments are reported that explore the implications of these results. Experiment 1 replicates the recent studies but limits the generalizability of the results to small target numbers. Experiments 2 and 3 show that the observed performance decrements are not due to a serial or even limited-capacity, parallel process. Experiment 4 suggests that decision factors idiosyncratic to the use of texture elements in a same-different task are responsible for the effect. It is concluded that the identification of simple visual features proceeds in parallel, with unlimited capacity (i.e., preattentively).

  4. Serial assessment of accessory pathway antegrade conduction in children.

    PubMed

    Satiya, Saawan B; Kannankeril, Prince J; Fish, Frank A; Radbill, Andrew E

    2016-01-01

    There is limited longitudinal data on accessory pathway (AP) antegrade conduction throughout childhood, with implications for risk stratification. Ten patients underwent serial electrophysiology study (EPS) with assessment of fastest 1:1 AP conduction. The median age at first and follow-up EPS was 0 (median 4 days) and 53 months. Median fastest 1:1 AP conduction was 255 ms at initial EPS and 275 ms at follow-up (P=0.24). The interval of time between studies had no influence on stability over time, nor was there any appreciable effect following changes in retrograde AP conduction. In conclusion, no patient displayed any marked shortening of 1:1 AP conduction over time.

  5. Serial biological conversion of coal into liquid fuels

    SciTech Connect

    Liu, R.Q.; Johnson, N.L.; Magruder, G.C.; Ackerson, M.D.; Vega, J.L.; Clausen, E.C.; Gaddy, J.L.

    1988-01-01

    Recently, several microorganisms have been shown to be capable of directly solubilizing low rank coals. This bioextract has a high molecular weight and is water soluble, but is not useful as a liquid fuel. This paper presents the results of studies to biologically convert the solubilized coal into more useful compounds. Preliminary experiments have been conducted to isolate cultures for the serial biological conversion of coal into alcohols. Coal particles have been solubilized employing an isolate from the surface of Arkansas lignite. Natural inocula, such as sheep rumen and sewage sludge, are then employed in developing cultures for converting the bioextract into alcohols. This paper presents preliminary results of experiments in coal solubilization and bioextract conversion.

  6. Serially connected solid oxide fuel cells having monolithic cores

    SciTech Connect

    Herceg, Joseph E.

    1987-01-01

    A solid oxide fuel cell for electrochemically combining fuel and oxidant for generating galvanic output, wherein the cell core has an array of cell segments electrically serially connected in the flow direction, each segment consisting of electrolyte walls and interconnect that are substantially devoid of any composite inert materials for support. Instead, the core is monolithic, where each electrolyte wall consists of thin layers of cathode and anode materials sandwiching a thin layer of electrolyte material therebetween. Means direct the fuel to the anode-exposed core passageways and means direct the oxidant to the cathode-exposed core passageways; and means also direct the galvanic output to an exterior circuit. Each layer of the electrolyte composite materials is of the order of 0.002-0.01 cm thick; and each layer of the cathode and anode materials is of the order of 0.002-0.05 cm thick. Between 2 and 50 cell segments may be connected in series.

  7. Bit-Serial Adder Based on Quantum Dots

    NASA Technical Reports Server (NTRS)

    Fijany, Amir; Toomarian, Nikzad; Modarress, Katayoon; Spotnitz, Mathew

    2003-01-01

    A proposed integrated circuit based on quantum-dot cellular automata (QCA) would function as a bit-serial adder. This circuit would serve as a prototype building block for demonstrating the feasibility of quantum-dots computing and for the further development of increasingly complex and increasingly capable quantum-dots computing circuits. QCA-based bit-serial adders would be especially useful in that they would enable the development of highly parallel and systolic processors for implementing fast Fourier, cosine, Hartley, and wavelet transforms. The proposed circuit would complement the QCA-based circuits described in "Implementing Permutation Matrices by Use of Quantum Dots" (NPO-20801), NASA Tech Briefs, Vol. 25, No. 10 (October 2001), page 42 and "Compact Interconnection Networks Based on Quantum Dots" (NPO-20855), which appears elsewhere in this issue. Those articles described the limitations of very-large-scale-integrated (VLSI) circuitry and the major potential advantage afforded by QCA. To recapitulate: In a VLSI circuit, signal paths that are required not to interact with each other must not cross in the same plane. In contrast, for reasons too complex to describe in the limited space available for this article, suitably designed and operated QCA-based signal paths that are required not to interact with each other can nevertheless be allowed to cross each other in the same plane without adverse effect. In principle, this characteristic could be exploited to design compact, coplanar, simple (relative to VLSI) QCA-based networks to implement complex, advanced interconnection schemes. To enable a meaningful description of the proposed bit-serial adder, it is necessary to further recapitulate the description of a quantum-dot cellular automation from the first-mentioned prior article: A quantum-dot cellular automaton contains four quantum dots positioned at the corners of a square cell. The cell contains two extra mobile electrons that can tunnel (in the

  8. The problem of multimodal concurrent serial order in behavior.

    PubMed

    Kolodny, Oren; Edelman, Shimon

    2015-09-01

    The "problem of serial order in behavior," as formulated and discussed by Lashley (1951), is arguably more pervasive and more profound both than originally stated and than currently appreciated. We spell out two complementary aspects of what we term the generalized problem of behavior: (i) multimodality, stemming from the disparate nature of the sensorimotor variables and processes that underlie behavior, and (ii) concurrency, which reflects the parallel unfolding in time of these processes and of their asynchronous interactions. We illustrate these on a number of examples, with a special focus on language, briefly survey the computational approaches to multimodal concurrency, offer some hypotheses regarding the manner in which brains address it, and discuss some of the broader implications of these as yet unresolved issues for cognitive science.

  9. Liquid sample delivery techniques for serial femtosecond crystallography.

    PubMed

    Weierstall, Uwe

    2014-07-17

    X-ray free-electron lasers overcome the problem of radiation damage in protein crystallography and allow structure determination from micro- and nanocrystals at room temperature. To ensure that consecutive X-ray pulses do not probe previously exposed crystals, the sample needs to be replaced with the X-ray repetition rate, which ranges from 120 Hz at warm linac-based free-electron lasers to 1 MHz at superconducting linacs. Liquid injectors are therefore an essential part of a serial femtosecond crystallography experiment at an X-ray free-electron laser. Here, we compare different techniques of injecting microcrystals in solution into the pulsed X-ray beam in vacuum. Sample waste due to mismatch of the liquid flow rate to the X-ray repetition rate can be addressed through various techniques.

  10. Serial femtosecond crystallography datasets from G protein-coupled receptors.

    PubMed

    White, Thomas A; Barty, Anton; Liu, Wei; Ishchenko, Andrii; Zhang, Haitao; Gati, Cornelius; Zatsepin, Nadia A; Basu, Shibom; Oberthür, Dominik; Metz, Markus; Beyerlein, Kenneth R; Yoon, Chun Hong; Yefanov, Oleksandr M; James, Daniel; Wang, Dingjie; Messerschmidt, Marc; Koglin, Jason E; Boutet, Sébastien; Weierstall, Uwe; Cherezov, Vadim

    2016-08-01

    We describe the deposition of four datasets consisting of X-ray diffraction images acquired using serial femtosecond crystallography experiments on microcrystals of human G protein-coupled receptors, grown and delivered in lipidic cubic phase, at the Linac Coherent Light Source. The receptors are: the human serotonin receptor 2B in complex with an agonist ergotamine, the human δ-opioid receptor in complex with a bi-functional peptide ligand DIPP-NH2, the human smoothened receptor in complex with an antagonist cyclopamine, and finally the human angiotensin II type 1 receptor in complex with the selective antagonist ZD7155. All four datasets have been deposited, with minimal processing, in an HDF5-based file format, which can be used directly for crystallographic processing with CrystFEL or other software. We have provided processing scripts and supporting files for recent versions of CrystFEL, which can be used to validate the data.

  11. Merging of synchrotron serial crystallographic data by a genetic algorithm.

    PubMed

    Zander, Ulrich; Cianci, Michele; Foos, Nicolas; Silva, Catarina S; Mazzei, Luca; Zubieta, Chloe; de Maria, Alejandro; Nanao, Max H

    2016-09-01

    Recent advances in macromolecular crystallography have made it practical to rapidly collect hundreds of sub-data sets consisting of small oscillations of incomplete data. This approach, generally referred to as serial crystallography, has many uses, including an increased effective dose per data set, the collection of data from crystals without harvesting (in situ data collection) and studies of dynamic events such as catalytic reactions. However, selecting which data sets from this type of experiment should be merged can be challenging and new methods are required. Here, it is shown that a genetic algorithm can be used for this purpose, and five case studies are presented in which the merging statistics are significantly improved compared with conventional merging of all data. PMID:27599735

  12. Serial femtosecond crystallography of soluble proteins in lipidic cubic phase

    DOE PAGESBeta

    Fromme, Raimund; Ishchenko, Andrii; Metz, Markus; Chowdhury, Shatabdi Roy; Basu, Shibom; Boutet, Sébastien; Fromme, Petra; White, Thomas A.; Barty, Anton; Spence, John C. H.; et al

    2015-08-04

    Serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs) enables high-resolution protein structure determination using micrometre-sized crystals at room temperature with minimal effects from radiation damage. SFX requires a steady supply of microcrystals intersecting the XFEL beam at random orientations. An LCP–SFX method has recently been introduced in which microcrystals of membrane proteins are grown and delivered for SFX data collection inside a gel-like membrane-mimetic matrix, known as lipidic cubic phase (LCP), using a special LCP microextrusion injector. Here, it is shown enabling a dramatic reduction in the amount of crystallized protein required for data collection compared with crystals deliveredmore » by liquid injectors. High-quality LCP–SFX data sets were collected for two soluble proteins, lysozyme and phycocyanin, using less than 0.1 mg of each protein.« less

  13. Serial femtosecond X-ray diffraction of enveloped virus microcrystals

    PubMed Central

    Lawrence, Robert M.; Conrad, Chelsie E.; Zatsepin, Nadia A.; Grant, Thomas D.; Liu, Haiguang; James, Daniel; Nelson, Garrett; Subramanian, Ganesh; Aquila, Andrew; Hunter, Mark S.; Liang, Mengning; Boutet, Sébastien; Coe, Jesse; Spence, John C. H.; Weierstall, Uwe; Liu, Wei; Fromme, Petra; Cherezov, Vadim; Hogue, Brenda G.

    2015-01-01

    Serial femtosecond crystallography (SFX) using X-ray free-electron lasers has produced high-resolution, room temperature, time-resolved protein structures. We report preliminary SFX of Sindbis virus, an enveloped icosahedral RNA virus with ∼700 Å diameter. Microcrystals delivered in viscous agarose medium diffracted to ∼40 Å resolution. Small-angle diffuse X-ray scattering overlaid Bragg peaks and analysis suggests this results from molecular transforms of individual particles. Viral proteins undergo structural changes during entry and infection, which could, in principle, be studied with SFX. This is an important step toward determining room temperature structures from virus microcrystals that may enable time-resolved studies of enveloped viruses. PMID:26798819

  14. Sexually transmitted infection and the evolution of serial monogamy

    PubMed Central

    McLeod, David V.; Day, Troy

    2014-01-01

    The selective forces shaping mating systems have long been of interest to biologists. One particular selective pressure that has received comparatively little attention is sexually transmitted infections (STIs). While it has been hypothesized that STIs could drive the evolutionary emergence of monogamy, there is little theoretical support. Here we use an evolutionary invasion analysis to determine what aspects of pathogen virulence and transmission are necessary for serial monogamy to evolve in a promiscuous population. We derive a biologically intuitive invasion condition in terms of population-specific quantities. From this condition, we obtain two main results. First, when pathogen virulence causes mortality rather than sterility, monogamy is more likely to evolve. Second, we find that at intermediate pathogen transmission rates, monogamy is the most selectively advantageous, whereas at high- and low-transmission rates, monogamy is generally selected against. As a result, it is possible for a pathogen to be highly virulent, yet for promiscuity to persist. PMID:25320174

  15. Serial interactome capture of the human cell nucleus.

    PubMed

    Conrad, Thomas; Albrecht, Anne-Susann; de Melo Costa, Veronica Rodrigues; Sauer, Sascha; Meierhofer, David; Ørom, Ulf Andersson

    2016-01-01

    Novel RNA-guided cellular functions are paralleled by an increasing number of RNA-binding proteins (RBPs). Here we present 'serial RNA interactome capture' (serIC), a multiple purification procedure of ultraviolet-crosslinked poly(A)-RNA-protein complexes that enables global RBP detection with high specificity. We apply serIC to the nuclei of proliferating K562 cells to obtain the first human nuclear RNA interactome. The domain composition of the 382 identified nuclear RBPs markedly differs from previous IC experiments, including few factors without known RNA-binding domains that are in good agreement with computationally predicted RNA binding. serIC extends the number of DNA-RNA-binding proteins (DRBPs), and reveals a network of RBPs involved in p53 signalling and double-strand break repair. serIC is an effective tool to couple global RBP capture with additional selection or labelling steps for specific detection of highly purified RBPs. PMID:27040163

  16. Split-plot designs for robotic serial dilution assays.

    PubMed

    Buzas, Jeffrey S; Wager, Carrie G; Lansky, David M

    2011-12-01

    This article explores effective implementation of split-plot designs in serial dilution bioassay using robots. We show that the shortest path for a robot to fill plate wells for a split-plot design is equivalent to the shortest common supersequence problem in combinatorics. We develop an algorithm for finding the shortest common supersequence, provide an R implementation, and explore the distribution of the number of steps required to implement split-plot designs for bioassay through simulation. We also show how to construct collections of split plots that can be filled in a minimal number of steps, thereby demonstrating that split-plot designs can be implemented with nearly the same effort as strip-plot designs. Finally, we provide guidelines for modeling data that result from these designs. PMID:21627628

  17. Split-plot designs for robotic serial dilution assays.

    PubMed

    Buzas, Jeffrey S; Wager, Carrie G; Lansky, David M

    2011-12-01

    This article explores effective implementation of split-plot designs in serial dilution bioassay using robots. We show that the shortest path for a robot to fill plate wells for a split-plot design is equivalent to the shortest common supersequence problem in combinatorics. We develop an algorithm for finding the shortest common supersequence, provide an R implementation, and explore the distribution of the number of steps required to implement split-plot designs for bioassay through simulation. We also show how to construct collections of split plots that can be filled in a minimal number of steps, thereby demonstrating that split-plot designs can be implemented with nearly the same effort as strip-plot designs. Finally, we provide guidelines for modeling data that result from these designs.

  18. Merging of synchrotron serial crystallographic data by a genetic algorithm

    PubMed Central

    Zander, Ulrich; Cianci, Michele; Foos, Nicolas; Silva, Catarina S.; Mazzei, Luca; Zubieta, Chloe; de Maria, Alejandro; Nanao, Max H.

    2016-01-01

    Recent advances in macromolecular crystallography have made it practical to rapidly collect hundreds of sub-data sets consisting of small oscillations of incomplete data. This approach, generally referred to as serial crystallography, has many uses, including an increased effective dose per data set, the collection of data from crystals without harvesting (in situ data collection) and studies of dynamic events such as catalytic reactions. However, selecting which data sets from this type of experiment should be merged can be challenging and new methods are required. Here, it is shown that a genetic algorithm can be used for this purpose, and five case studies are presented in which the merging statistics are significantly improved compared with conventional merging of all data. PMID:27599735

  19. Serial femtosecond crystallography datasets from G protein-coupled receptors

    PubMed Central

    White, Thomas A.; Barty, Anton; Liu, Wei; Ishchenko, Andrii; Zhang, Haitao; Gati, Cornelius; Zatsepin, Nadia A.; Basu, Shibom; Oberthür, Dominik; Metz, Markus; Beyerlein, Kenneth R.; Yoon, Chun Hong; Yefanov, Oleksandr M.; James, Daniel; Wang, Dingjie; Messerschmidt, Marc; Koglin, Jason E.; Boutet, Sébastien; Weierstall, Uwe; Cherezov, Vadim

    2016-01-01

    We describe the deposition of four datasets consisting of X-ray diffraction images acquired using serial femtosecond crystallography experiments on microcrystals of human G protein-coupled receptors, grown and delivered in lipidic cubic phase, at the Linac Coherent Light Source. The receptors are: the human serotonin receptor 2B in complex with an agonist ergotamine, the human δ-opioid receptor in complex with a bi-functional peptide ligand DIPP-NH2, the human smoothened receptor in complex with an antagonist cyclopamine, and finally the human angiotensin II type 1 receptor in complex with the selective antagonist ZD7155. All four datasets have been deposited, with minimal processing, in an HDF5-based file format, which can be used directly for crystallographic processing with CrystFEL or other software. We have provided processing scripts and supporting files for recent versions of CrystFEL, which can be used to validate the data. PMID:27479354

  20. Serial femtosecond crystallography of soluble proteins in lipidic cubic phase.

    PubMed

    Fromme, Raimund; Ishchenko, Andrii; Metz, Markus; Chowdhury, Shatabdi Roy; Basu, Shibom; Boutet, Sébastien; Fromme, Petra; White, Thomas A; Barty, Anton; Spence, John C H; Weierstall, Uwe; Liu, Wei; Cherezov, Vadim

    2015-09-01

    Serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs) enables high-resolution protein structure determination using micrometre-sized crystals at room temperature with minimal effects from radiation damage. SFX requires a steady supply of microcrystals intersecting the XFEL beam at random orientations. An LCP-SFX method has recently been introduced in which microcrystals of membrane proteins are grown and delivered for SFX data collection inside a gel-like membrane-mimetic matrix, known as lipidic cubic phase (LCP), using a special LCP microextrusion injector. Here, it is demonstrated that LCP can also be used as a suitable carrier medium for microcrystals of soluble proteins, enabling a dramatic reduction in the amount of crystallized protein required for data collection compared with crystals delivered by liquid injectors. High-quality LCP-SFX data sets were collected for two soluble proteins, lysozyme and phycocyanin, using less than 0.1 mg of each protein.

  1. Serial femtosecond crystallography datasets from G protein-coupled receptors.

    PubMed

    White, Thomas A; Barty, Anton; Liu, Wei; Ishchenko, Andrii; Zhang, Haitao; Gati, Cornelius; Zatsepin, Nadia A; Basu, Shibom; Oberthür, Dominik; Metz, Markus; Beyerlein, Kenneth R; Yoon, Chun Hong; Yefanov, Oleksandr M; James, Daniel; Wang, Dingjie; Messerschmidt, Marc; Koglin, Jason E; Boutet, Sébastien; Weierstall, Uwe; Cherezov, Vadim

    2016-01-01

    We describe the deposition of four datasets consisting of X-ray diffraction images acquired using serial femtosecond crystallography experiments on microcrystals of human G protein-coupled receptors, grown and delivered in lipidic cubic phase, at the Linac Coherent Light Source. The receptors are: the human serotonin receptor 2B in complex with an agonist ergotamine, the human δ-opioid receptor in complex with a bi-functional peptide ligand DIPP-NH2, the human smoothened receptor in complex with an antagonist cyclopamine, and finally the human angiotensin II type 1 receptor in complex with the selective antagonist ZD7155. All four datasets have been deposited, with minimal processing, in an HDF5-based file format, which can be used directly for crystallographic processing with CrystFEL or other software. We have provided processing scripts and supporting files for recent versions of CrystFEL, which can be used to validate the data. PMID:27479354

  2. Serial position effects in recognition memory for odors: a reexamination.

    PubMed

    Miles, Christopher; Hodder, Kathryn

    2005-10-01

    Seven experiments examined recognition memory for sequentially presented odors. Following Reed (2000), participants were presented with a sequence of odors and then required to identify an odor from the sequence in a test probe comprising 2 odors. The pattern of results obtained by Reed (2000, although statistically marginal) demonstrated enhanced recognition for odors presented at the start (primacy) and end (recency) of the sequence: a result that we failed to replicate in any of the experiments reported here. Experiments 1 and 3 were designed to replicate Reed (2000), employing five-item and seven-item sequences, respectively, and each demonstrated significant recency, with evidence of primacy in Experiment 3 only. Experiment 2 replicated Experiment 1, with reduced interstimulus intervals, and produced a null effect of serial position. The ease with which the odors could be verbally labeled was manipulated in Experiments 4 and 5. Nameable odors produced a null effect of serial position (Experiment 4), and hard-to-name odors produced a pronounced recency effect (Experiment 5); nevertheless, overall rates of recognition were remarkably similar for the two experiments at around 70%. Articulatory suppression reduced recognition accuracy (Experiment 6), but recency was again present in the absence of primacy. Odor recognition performance was immune to the effects of an interleaved odor (Experiment 7), and, again, both primacy and recency effects were absent. There was no evidence of olfactory fatigue: Recognition accuracy improved across trials (Experiment 1). It is argued that the results of the experiments reported here are generally consistent with that body of work employing hard-to-name visual stimuli, where recency is obtained in the absence of primacy when the retention interval is short.

  3. Serial batch leaching procedure for characterization of coal fly ash.

    PubMed

    Hesbach, Peter A; Kim, Ann G; Abel, Alexander S P; Lamey, Steven C

    2010-09-01

    Although many leaching methods have been used for various purposes by research groups, industries, and regulators, there is still a need for a simple but comprehensive approach to leaching coal utilization by-products and other granular materials in order to estimate potential release of heavy metals when these materials are exposed to natural fluids. A serial batch characterization method has been developed at the National Energy Technology Laboratory that can be completed in 2-3 days to serve as a screening tool. The procedure provides an estimate of cumulative metals release under varying pH conditions, and leaching the sample at increasing liquid/solid ratios can indicate the rate at which this process will occur. This method was applied to eight fly ashes, adapted to the acidic or alkaline nature of the ash. The leachates were analyzed for 30 elements. The test was run in quadruplicate, and the relative standard deviation (RSD) was used as a measure of method reproducibility. RSD values are between 0.02 and 0.70, with the majority of the RSD values less than 0.3. The serial batch leaching procedure was developed as a simple, relatively quick, yet comprehensive method of estimating the risk of heavy metal release from fly ash when it is exposed to natural fluids, such as acid rain or groundwater. Tests on a random selection of coal fly ashes have shown it to be a reasonably precise method for estimating the availability and long-term release of cations from fly ash.

  4. Modeling graphite anodes with serial and transmission line models

    NASA Astrophysics Data System (ADS)

    Illig, J.; Ender, M.; Weber, A.; Ivers-Tiffée, E.

    2015-05-01

    Electrochemical impedance spectroscopy (EIS) is an indispensable technique for the investigation of polarization processes in Lithium-ion Batteries. These cause performance limitation or degradation. A physically meaningful impedance model is key when drawing conclusions on further cell improvement. This study introduces an in-depth impedance analysis of a commercial high-power graphite anode. The impedance spectra measured between 0 °C and 30 °C and 0%-100% SOC were analyzed by the distribution of relaxation times (DRT-method), enabling a separation of loss processes by their individual time constants. Using this method, we separated charge transfer resistance and solid electrolyte interface resistance at medium frequencies (10 Hz-200 Hz) and the contact resistance anode/current collector in the at high frequency range (5 kHz-100 kHz). Two fundamentally different model structures were set up, either (i) two modifications of a serial model connecting RQ-elements and a Warburg element for solid state diffusion, or (ii) three modifications of a transmission line model with one-path or two-path design. The suitability of all serial and TLM model structures was tested, and the fitting procedure was supported using microstructure parameters gained from x-ray tomography. The favored one-path transmission line model reveals that the lithium-ion transport in the electrolyte contributes more to polarization than expected. Impediment of lithium-ion transport is caused by the pore structure and the tortuosity of the high-power graphite anode, and has to be considered for meaningful interpretation of impedance spectra.

  5. Depression and pain: testing of serial multiple mediators

    PubMed Central

    Wongpakaran, Tinakon; Wongpakaran, Nahathai; Tanchakvaranont, Sitthinant; Bookkamana, Putipong; Pinyopornpanish, Manee; Wannarit, Kamonporn; Satthapisit, Sirina; Nakawiro, Daochompu; Hiranyatheb, Thanita; Thongpibul, Kulvadee

    2016-01-01

    Purpose Despite the fact that pain is related to depression, few studies have been conducted to investigate the variables that mediate between the two conditions. In this study, the authors explored the following mediators: cognitive function, self-sacrificing interpersonal problems, and perception of stress, and the effects they had on pain symptoms among patients with depressive disorders. Participants and methods An analysis was performed on the data of 346 participants with unipolar depressive disorders. The 17-item Hamilton Depression Rating Scale, Mini-Mental State Examination, the pain subscale of the health-related quality of life (SF-36), the self-sacrificing subscale of the Inventory of Interpersonal Problems, and the Perceived Stress Scale were used. Parallel multiple mediator and serial multiple mediator models were used. An alternative model regarding the effect of self-sacrificing on pain was also proposed. Results Perceived stress, self-sacrificing interpersonal style, and cognitive function were found to significantly mediate the relationship between depression and pain, while controlling for demographic variables. The total effect of depression on pain was significant. This model, with an additional three mediators, accounted for 15% of the explained variance in pain compared to 9% without mediators. For the alternative model, after controlling for the mediators, a nonsignificant total direct effect level of self-sacrificing was found, suggesting that the effect of self-sacrificing on pain was based only on an indirect effect and that perceived stress was found to be the strongest mediator. Conclusion Serial mediation may help us to see how depression and pain are linked and what the fundamental mediators are in the chain. No significant, indirect effect of self-sacrificing on pain was observed, if perceived stress was not part of the depression and/or cognitive function mediational chain. The results shown here have implications for future

  6. Serial measurements of serum human placental lactogen (hPL) and serial ultrasound examinations in the evaluation of fetal growth.

    PubMed

    Sørensen, S; von Tabouillot, D; Schioler, V; Greisen, G; Petersen, S; Larsen, T

    2000-11-01

    Serial serum hPL measurements and serial ultrasound fetometry were compared in the evaluation of fetal growth by relating these two parameters to size at birth and to clinical factors known to influence size at birth. The data were from a prospective study of 1000 consecutive pregnant women considered to be at risk for fetal growth retardation with retrospective analysis. Serum hPL was measured by radioimmunoassay and fetal weight estimated by ultrasound every 3 weeks during the last trimester. hPL values were expressed as multiples of the median (MoM) and linear regression analysis of the hPL MoM values was carried out for each pregnancy to find the slope of the line (hPL-slope); at least 3 serum hPL values were required. The estimated fetal weight and weight-for-age at birth was expressed in Z-scores. The individual intrauterine growth velocity was calculated by regression analysis and expressed as change in Z-score for 12 weeks. At least two ultrasound measurements over an interval of at least 42 days were used to estimate the fetal growth velocity. In 588 women the file was complete. The main outcome measures were the individual mean hPL, hPL-slope, fetal growth velocity, birth weight deviation, smoking in pregnancy and diagnosis of preeclampsia. A significant correlation was found between the hPL-slope and the intrauterine fetal growth velocity (r=0.34), and between hPL-slope and birth weight deviation (r=0.32). Mean hPL was correlated to birth weight deviation (r=0.27), but only very weakly to intrauterine growth velocity (r=0.08). hPL-slope and intrauterine growth velocity independently predicted birth weight deviation. Heavy smoking which was stopped before the third trimester was not associated with low intrauterine growth velocity, but with a low hPL-slope. Preeclampsia was associated with a trend towards low and decreasing hPL and with an increasing intrauterine growth velocity and birth weight deviation. In conclusion the rate of change of serial h

  7. 9 CFR 113.8 - In vitro tests for serial release.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false In vitro tests for serial release. 113... REQUIREMENTS Applicability § 113.8 In vitro tests for serial release. (a) Master Seed which has been established as pure, safe, and immunogenic shall be used for preparing seed for production as specified in...

  8. 9 CFR 113.8 - In vitro tests for serial release.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false In vitro tests for serial release. 113... REQUIREMENTS Applicability § 113.8 In vitro tests for serial release. (a) Master Seed which has been established as pure, safe, and immunogenic shall be used for preparing seed for production as specified in...

  9. Subject-Verb Agreement in Children and Adults: Serial or Hierarchical Processing?

    ERIC Educational Resources Information Center

    Negro, Isabelle; Chanquoy, Lucile; Fayol, Michel; Louis-Sidney, Maryse

    2005-01-01

    Two processes, serial and hierarchical, are generally opposed to account for grammatical encoding in language production. In a developmental perspective, the question addressed here is whether the subject-verb agreement during writing is computed serially, once the words are linearly ordered in the sentence, or hierarchically, as soon as the…

  10. Male Stereotypes in Radio Serials of the 1930s and 1940s.

    ERIC Educational Resources Information Center

    St John, Jacqueline

    Because they tend to reflect dominant cultural values that are more obvious and taken for granted by historians, male stereotypes in radio serials, or "soap operas," have been ignored. They are prevalent, however, especially in the representative "Golden Age" productions of Anne and Frank Hummert. The Hummerts produced 46% of the serials current…

  11. Save the last dance for me: unwanted serial position effects in jury evaluations.

    PubMed

    Bruine de Bruin, Wändi

    2005-03-01

    Whenever competing options are considered in sequence, their evaluations may be affected by order of appearance. Such serial position effects would threaten the fairness of competitions using jury evaluations. Randomization cannot reduce potential order effects, but it does give candidates an equal chance of being assigned to preferred serial positions. Whether, or what, serial position effects emerge may depend on the cognitive demands of the judgment task. In end-of-sequence procedures, final scores are not given until all candidates have performed, possibly burdening judges' memory. If judges' evaluations are based on how well they remember performances, serial position effects may resemble those found with free recall. Candidates may also be evaluated step-by-step, immediately after each performance. This procedure should not burden memory, though it may produce different serial position effects. Yet, this paper reports similar serial position effects with end-of-sequence and step-by-step procedures used for the Eurovision Song Contest: Ratings increased with serial position. The linear order effect was replicated in the step-by-step judgments of World and European Figure Skating Contests. It is proposed that, independent of the evaluation procedure, judges' initial impressions of sequentially appearing candidates may be formed step-by-step, yielding serial position effects.

  12. The Nature of Verbal Short-Term Impairment in Dyslexia: The Importance of Serial Order

    PubMed Central

    Majerus, Steve; Cowan, Nelson

    2016-01-01

    Verbal short-term memory (STM) impairment is one of the most consistent associated deficits observed in developmental reading disorders such as dyslexia. Few studies have addressed the nature of this STM impairment, especially as regards the ability to temporarily store serial order information. This question is important as studies in typically developing children have shown that serial order STM abilities are predictors of oral and written language development. Associated serial order STM deficits in dyslexia may therefore further increase the learning difficulties in these populations. In this mini review, we show that specific serial order STM impairment is frequently reported in both dyslexic children and adults with a history of dyslexia. Serial order STM impairment appears to occur for the retention of both verbal and visuo-spatial sequence information. Serial order STM impairment is, however, not a characteristic of every individual dyslexic subject and is not specific to dyslexia. Future studies need to determine whether serial order STM impairment is a risk factor which, in association with phonological processing deficits, can lead to dyslexia or whether serial order STM impairment reflects associated deficits causally unrelated to dyslexia. PMID:27752247

  13. 9 CFR 114.14 - Extension of expiration date for a serial or subserial.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... serial or subserial. 114.14 Section 114.14 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... PRODUCTION REQUIREMENTS FOR BIOLOGICAL PRODUCTS § 114.14 Extension of expiration date for a serial or subserial. (a) Unless otherwise provided for in a filed Outline of Production for the product,...

  14. 48 CFR 211.274-5 - Policy for assignment of Government-assigned serial numbers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Using and Maintaining Requirements Documents 211.274-5 Policy for assignment of Government-assigned serial numbers. It is DoD policy that contractors apply Government-assigned serial numbers, such as tail... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Policy for assignment...

  15. 48 CFR 211.274-5 - Policy for assignment of Government-assigned serial numbers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Using and Maintaining Requirements Documents 211.274-5 Policy for assignment of Government-assigned serial numbers. It is DoD policy that contractors apply Government-assigned serial numbers, such as tail... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Policy for assignment...

  16. 48 CFR 211.274-5 - Policy for assignment of Government-assigned serial numbers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Using and Maintaining Requirements Documents 211.274-5 Policy for assignment of Government-assigned serial numbers. It is DoD policy that contractors apply Government-assigned serial numbers, such as tail... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Policy for assignment...

  17. 48 CFR 211.274-5 - Policy for assignment of Government-assigned serial numbers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Using and Maintaining Requirements Documents 211.274-5 Policy for assignment of Government-assigned serial numbers. It is DoD policy that contractors apply Government-assigned serial numbers, such as tail... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Policy for assignment...

  18. 48 CFR 211.274-5 - Policy for assignment of Government-assigned serial numbers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Using and Maintaining Requirements Documents 211.274-5 Policy for assignment of Government-assigned serial numbers. It is DoD policy that contractors apply Government-assigned serial numbers, such as tail... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Policy for assignment...

  19. The Effect of Rate of Presentation on Digit Serial Recall in Reading Retarded Children.

    ERIC Educational Resources Information Center

    Gan, Jennifer; Tymchuk, Alexander J.

    This study examined the effect of presentation rate on accuracy of digit serial recall and on serial position curves of digit strings of different lengths with 18 boys classified as reading retarded and a comparison group of children (ages for both groups averaged 11 years) who read at grade level. The results indicated that normal children…

  20. Dynamic Binding of Identity and Location Information: A Serial Model of Multiple Identity Tracking

    ERIC Educational Resources Information Center

    Oksama, Lauri; Hyona, Jukka

    2008-01-01

    Tracking of multiple moving objects is commonly assumed to be carried out by a fixed-capacity parallel mechanism. The present study proposes a serial model (MOMIT) to explain performance accuracy in the maintenance of multiple moving objects with distinct identities. A serial refresh mechanism is postulated, which makes recourse to continuous…

  1. In Support of Collection Assessment: The Role of Automation in the Acquisitions and Serials Departments.

    ERIC Educational Resources Information Center

    Hawks, Carol Pitts

    1992-01-01

    Describes the role of automation in library acquisitions and serials departments in support of collection development. Highlights include workstations and expert systems; links to external databases; vendor services, including serials services and online review and selection of approval books; and automated access to collection development…

  2. Serial Position Effects in the Identification of Letters, Digits, and Symbols

    ERIC Educational Resources Information Center

    Tydgat, Ilse; Grainger, Jonathan

    2009-01-01

    In 6 experiments, the authors investigated the form of serial position functions for identification of letters, digits, and symbols presented in strings. The results replicated findings obtained with the target search paradigm, showing an interaction between the effects of serial position and type of stimulus, with symbols generating a distinct…

  3. Automated Serials Control at the Indian Institutes of Technology: An Overview

    ERIC Educational Resources Information Center

    Ghosh, Tapas Kumar; Panda, K. C.

    2011-01-01

    Purpose: The purpose of this paper is to highlight the functional attributes of the automated serials control systems of the libraries in seven Indian Institutes of Technology (IITs) and provide a comparative analysis. Design/methodology/approach: Features of the serials control modules of the library management systems (LMSs) in use in the…

  4. Using Signal Detection Theory to Model Changes in Serial Learning of Radiological Image Interpretation

    ERIC Educational Resources Information Center

    Boutis, Kathy; Pecaric, Martin; Seeto, Brian; Pusic, Martin

    2010-01-01

    Signal detection theory (SDT) parameters can describe a learner's ability to discriminate (d[prime symbol]) normal from abnormal and the learner's criterion ([lambda]) to under or overcall abnormalities. To examine the serial changes in SDT parameters with serial exposure to radiological cases. 46 participants were recruited for this study: 20…

  5. 27 CFR 20.179 - Package identification number or serial number.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... number or serial number. 20.179 Section 20.179 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... Package identification number or serial number. (a) Requirement. A dealer who fills packages with specially denatured spirits shall mark each package with a package identification number, in accordance...

  6. 27 CFR 20.179 - Package identification number or serial number.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... number or serial number. 20.179 Section 20.179 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... Package identification number or serial number. (a) Requirement. A dealer who fills packages with specially denatured spirits shall mark each package with a package identification number, in accordance...

  7. Visual and Phonological Similarity Effects in Verbal Immediate Serial Recall: A Test with Kanji Materials

    ERIC Educational Resources Information Center

    Saito, Satoru; Logie, Robert H.; Morita, Aiko; Law, Anna

    2008-01-01

    In a series of three experiments, native speakers of Japanese performed serial ordered written recall of visually presented Japanese kanji characters that varied systematically in visual and phonological similarity. Overall effects of phonological similarity were observed for retention of serial order under silent reading in Experiments 1 and 3…

  8. Analysis of Readex's Serial Set MARC Records: Improving the Data for the Library Catalog

    ERIC Educational Resources Information Center

    Draper, Daniel; Lederer, Naomi

    2013-01-01

    Colorado State University Libraries (CSUL) purchased the digitized "United States Congressional Serial Set," 1817-1994 and "American State Papers" (1789-1838) from the Readex Division of NewsBank, Inc. and, once funds and records were available, the accompanying MARC records. The breadth of information found in the "Serial Set" is described, along…

  9. The Locus of Serial Processing in Reading Aloud: Orthography-to-Phonology Computation or Speech Planning?

    ERIC Educational Resources Information Center

    Mousikou, Petroula; Rastle, Kathleen; Besner, Derek; Coltheart, Max

    2015-01-01

    Dual-route theories of reading posit that a sublexical reading mechanism that operates serially and from left to right is involved in the orthography-to-phonology computation. These theories attribute the masked onset priming effect (MOPE) and the phonological Stroop effect (PSE) to the serial left-to-right operation of this mechanism. However,…

  10. Psychological profiling of offender characteristics from crime behaviors in serial rape offences.

    PubMed

    Kocsis, Richard N; Cooksey, Ray W; Irwin, Harvey J

    2002-04-01

    Criminal psychological profiling has progressively been incorporated into police procedures despite a dearth of empirical research. Indeed, in the study of serial violent crimes for the purpose of psychological profiling, very few original, quantitative, academically reviewed studies actually exist. This article reports on the analysis of 62 incidents of serial sexual assault. The statistical procedure of multidimensional scaling was employed in the analysis of this data, which in turn produced a five-cluster model of serial rapist behavior. First, a central cluster of behaviors were identified that represent common behaviors to all patterns of serial rape. Second, four distinct outlying patterns were identified as demonstrating distinct offence styles, these being assigned the following descriptive labels brutality, intercourse, chaotic, and ritual. Furthermore, analysis of these patterns also identified distinct offender characteristics that allow for the use of empirically robust offender profiles in future serial rape investigations. PMID:12113160

  11. Psychological profiling of offender characteristics from crime behaviors in serial rape offences.

    PubMed

    Kocsis, Richard N; Cooksey, Ray W; Irwin, Harvey J

    2002-04-01

    Criminal psychological profiling has progressively been incorporated into police procedures despite a dearth of empirical research. Indeed, in the study of serial violent crimes for the purpose of psychological profiling, very few original, quantitative, academically reviewed studies actually exist. This article reports on the analysis of 62 incidents of serial sexual assault. The statistical procedure of multidimensional scaling was employed in the analysis of this data, which in turn produced a five-cluster model of serial rapist behavior. First, a central cluster of behaviors were identified that represent common behaviors to all patterns of serial rape. Second, four distinct outlying patterns were identified as demonstrating distinct offence styles, these being assigned the following descriptive labels brutality, intercourse, chaotic, and ritual. Furthermore, analysis of these patterns also identified distinct offender characteristics that allow for the use of empirically robust offender profiles in future serial rape investigations.

  12. The force of myth on popular narratives: the case of melodramatic serials.

    PubMed

    Lozano, E

    1992-08-01

    Studies in the US, Colombia, and Peru point to the didactic, educative, or instructional potential of television in general and of melodramatic serials in particular. Very few television genres have attracted as much scholarly attention as melodramatic serials. Melodramatic serials such as American soap operas and Latin American telenovelas work with the narrative logic of myth and can be endowed with the cultural and performative power of myth. Melodramatic serials are very similar to mythical narratives. That textual similarity between melodramatic serials and mythical narratives suggests that the former may function as myth, a pedagogical and enculturating discourse. It may be that certain modes of entertainment and education continuously overlap into a general activity of social enculturation which fails to recognize the formal boundaries of ideological discourses.

  13. IEEE 1394/firewire a low cost, high speed, digital serial bus

    SciTech Connect

    Gaunt, R.

    1997-05-01

    Does the world need yet another 1/0 bus standard? If you need fast and cheap serial video communication, then the answer is yes. As technology advances, so too must data transport mechanisms advance. You can`t expect RS-232 to support real-time digital video, and if you can`t afford expensive professional serial video interfaces, (such as Sony`s Serial Digital Interface), Firewire may be a good solution. IEEE 1394, or commonly known as Firewire, is a general purpose serial bus that meets many of the 1/0 needs of today`s video and multimedia developers. For those of you who only read the first paragraph, here`s Firewire in a nutshell: It provides a guaranteed transfer rate of 10OMbps or 20OMbps of digital data (such as video direct from camera to computer), over an inexpensive, non-proprietary serial bus. Here is a list of its features.

  14. Design, synthesis and characterization of the advanced tritium breeder: Li4+xSi1-xAlxO4 ceramics

    NASA Astrophysics Data System (ADS)

    Zhao, Linjie; Long, Xinggui; Chen, Xiaojun; Xiao, Chengjian; Gong, Yu; Guan, Qiushi; Li, Jiamao; Xie, Lei; Chen, Xiping; Peng, Shuming

    2015-12-01

    Li4+xSi1-xAlxO4 solid solutions which were designed as the advanced tritium breeder were obtained by solid state reactions. Samples were systematically characterized by various techniques. XRD, neutron diffraction and Raman results showed that the Aluminum substituted silicon into the Li4SiO4 lattice and Li+ interstitials formed as a result of charge compensation. Rietveld refinements of neutron diffraction showed that the crystalline structure had been expanded as Al-doped. Moreover, the lithium atom density, thermal conductivity and the mechanical property of the Li4+xSi1-xAlxO4 ceramics were improved relative to the Li4SiO4.

  15. Structure and dielectric properties of solid solutions Bi7Ti4 + x W x Ta1-2 x O21 ( x = 0-0.5)

    NASA Astrophysics Data System (ADS)

    Zubkov, S. V.; Vlasenko, V. G.; Shuvaeva, V. A.; Shevtsova, S. I.

    2016-01-01

    A number of solid solutions Bi7Ti4 + x W x Ta1-2 x O21 ( x = 0-0.5) have been synthesized from oxides by solid-phase reaction. The crystal structure, the electrophysical characteristics, and the microstructure of the prepared ceramic samples have been studied. According to X-ray powder diffraction, all the compounds are single-phase with the structure of mixed-layer Aurivillius phases ( m = 2.5) with the orthorhombic crystal lattice (space group I2 cm, Z = 2). Temperature dependences of the relative permittivity ɛ( T) of the compound have been measured, from which it has been found that the Curie temperature T C of perovskite-like oxides Bi7Ti4 + x W x Ta1-2 x O21 ( x = 0-0.5) decreases linearly as substitution parameter x decreases. The activation energies of charge carriers have been found in different temperature ranges.

  16. A (4x2) reconstruction of CuInSe{sub 2} (001) studied by low-energy electron diffraction and soft x-ray photoemission spectroscopy

    SciTech Connect

    Deniozou, Th.; Esser, N.; Schulmeyer, Th.; Hunger, R.

    2006-01-30

    Clean and flat (001) surfaces of CuInSe{sub 2}/GaAs grown by molecular-beam epitaxy could be prepared by the combination of a Se capping and decapping process and subsequent Ar{sup +} ion sputtering and annealing. The formation of a (4x2) reconstruction was observed with low-energy electron diffraction. Soft x-ray photoemission spectroscopy was performed on the prepared surfaces and revealed surface core-level binding energy shifts in the Cu 2p{sub 3/2}, Se 3d, and In 4d levels which are associated with surface atoms. The structure model of a combined metal adatom-Se dimer structure is proposed to refer to the (4x2) reconstruction.

  17. Re-evaluating the 38th Parallel Serial Impact Hypothesis

    NASA Astrophysics Data System (ADS)

    Evans, K. R.; Davis, G. H.; Miao, X.; Mickus, K. L.; Miller, J. F.; Morrow, J. R.

    2008-12-01

    The idea that the 38th-parallel structures across Kansas, Missouri, and Illinois are serial impacts has been controversial. In addition to the original eight, two other structures are proximal to the 38th parallel, Dent Branch and Silver City Dome. Only Weaubleau, Decaturville, and Crooked Creek contain quartz grains with multiple directions of planar deformational features (PDFs). Shatter cones have been found at Decaturville and Crooked Creek. Key macroscopic observations of these impacts include: (1) circular outlines and notable central uplifts, (2) remarkably intense levels of structural deformation (folding, faulting, fracturing, and brecciation), (3) deformation dying out with depth and laterally away from the central uplift, and (4) associated igneous rocks only as clasts. From field and core studies and published reports, we consider other structures along the 38th parallel to be dubious (Hazelgreen), intrusive, (Hick's Dome), or volcanic in origin (Silver City Dome, Rose Dome, Furnace Creek, Dent Branch, and Avon). The age of the Weaubleau structure is constrained biostratigraphically as middle Mississippian (latest Osagean or early Meramecian). Crooked Creek and Decaturville are deeply eroded; their ages are poorly constrained. Crooked Creek contains isolated blocks of sandstone of late Osagean age, but the stratigraphic context of the blocks is poorly known. Other investigators contend the age of Decaturville is Pennsylvanian or Permian, based on CRM paleomagnetism and occurrence of an isolated sulfide breccia body in the central uplift. The Ozark plateau experienced Missouri Valley Type (MVT) sulfide mineralization during the Ouachita orogeny, but our examination of a sample from the sulfide breccia shows it is shattered pyrite and differs from typical MVT deposits. If the breccia is not associated with the regional mineralization, a middle Mississippian age cannot be excluded. Weaubleau, Decaturville, and Crooked Creek are aligned across 199 km. A

  18. Density of electronic states and dispersion of optical functions of defect chalcopyrite CdGa{sub 2}X{sub 4} (X = S, Se): DFT study

    SciTech Connect

    Reshak, A.H.; Khan, Saleem Ayaz

    2013-11-15

    Graphical abstract: - Highlights: • FPLAPW method is used for calculating the electronic and optical properties of CdGa{sub 2}X{sub 4}. • Electronic and optical properties were calculated using LDA, GGA, EVGGA and mBJ. • Band gap conformed that CdGa{sub 2}X{sub 4} are semiconductors fit for UV and visible light. • The ECD shows that change in the bond length and bond nature affect the band gap. • The dielectric tensor components and its derivatives show considerable anisotropy. - Abstract: A density functional theory (DFT) based on full potential linear augmented plane wave (FPLAPW) was used for calculating the electronic structure, charge density and optical properties of CdGa{sub 2}X{sub 4} (X = S, Se) compounds. Local density approximation (LDA), generalized gradient approximation (GGA), Engle Vasko generalized gradient approximation (EVGGA) and recently modified Becke–Johnson (mBJ) were applied to calculate the band structure, total and partial density of states. The investigation of band structures and density of states of CdGa{sub 2}X{sub 4} (X = S, Se) elucidate that mBJ potential show close agreement to the experimental results. The mBJ potential was selected for further explanation of optical properties of CdGa{sub 2}X{sub 4} (X = S, Se). The study of electronic charge density contours shows that change in the bond lengths and bond nature affect the band gap of the compounds. The two non-zero dielectric tensor components and its derivatives show considerable anisotropy between the perpendicular and parallel components. The present work provide accurate information about the combination (hybridization) of orbital, formation of bands and dispersion of non-zero tensor components of CdGa{sub 2}X{sub 4} (X = S, Se)

  19. Technique and considerations in the use of 4x1 ring high-definition transcranial direct current stimulation (HD-tDCS).

    PubMed

    Villamar, Mauricio F; Volz, Magdalena Sarah; Bikson, Marom; Datta, Abhishek; Dasilva, Alexandre F; Fregni, Felipe

    2013-07-14

    High-definition transcranial direct current stimulation (HD-tDCS) has recently been developed as a noninvasive brain stimulation approach that increases the accuracy of current delivery to the brain by using arrays of smaller "high-definition" electrodes, instead of the larger pad-electrodes of conventional tDCS. Targeting is achieved by energizing electrodes placed in predetermined configurations. One of these is the 4x1-ring configuration. In this approach, a center ring electrode (anode or cathode) overlying the target cortical region is surrounded by four return electrodes, which help circumscribe the area of stimulation. Delivery of 4x1-ring HD-tDCS is capable of inducing significant neurophysiological and clinical effects in both healthy subjects and patients. Furthermore, its tolerability is supported by studies using intensities as high as 2.0 milliamperes for up to twenty minutes. Even though 4x1 HD-tDCS is simple to perform, correct electrode positioning is important in order to accurately stimulate target cortical regions and exert its neuromodulatory effects. The use of electrodes and hardware that have specifically been tested for HD-tDCS is critical for safety and tolerability. Given that most published studies on 4x1 HD-tDCS have targeted the primary motor cortex (M1), particularly for pain-related outcomes, the purpose of this article is to systematically describe its use for M1 stimulation, as well as the considerations to be taken for safe and effective stimulation. However, the methods outlined here can be adapted for other HD-tDCS configurations and cortical targets.

  20. Fabrication of spinel Li4-xTi5O12 via ion exchange for high-rate lithium-ion batteries

    NASA Astrophysics Data System (ADS)

    Cheng, Chongling; Liu, Hongjiang; Li, Jun; Xue, Xin; Cao, Hui; Wang, Dayang; Shi, Liyi

    2015-06-01

    The present work demonstrates that lithium ions can be stepwise substituted by protons from spinel Li4Ti5O12 crystalline particles though simple ion-exchange in aqueous HCl solution with the aid of heat treatment. This enables us to continuously tune the Li-to-Ti stoichiometric ratios from 0.80 to 0.59, 0.41, 0.21, 0.15, and 0.09, thus transforming Li4Ti5O12 to Li4-xTi5O12 nanocrystals. The resulting nanocrystals maintain the spinel crystal structure when x becomes smaller than 3. Among as-prepared the Li4-xTi5O12 crystalline particles, Li1Ti5O12 shows the highest capacity of 193 mAh g-1 at 1C and 148 mAh g-1 at 20C, lower current impedance (47 Ω), significantly improved rate capability and fairly long cycle life. This excellent electrochemical performance makes spinel Li4-xTi5O12 particles as a promising anode candidate for lithium ion batteries superior.