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Sample records for 4x5 copy negative

  1. 15. Photographic copy englargement from a 4x5 copy negative (Original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Photographic copy englargement from a 4x5 copy negative (Original drawing located on abandoned NASA site, currently owned by the City of Downey, Downey, California). 1980 BLDG 10, BLDG 42 FLOOR PLAN, NASA MARCH 15 1980. - NASA Industrial Plant, Maintenance Facility, 12214 Lakewood Boulevard, Downey, Los Angeles County, CA

  2. 14. Photographic copy englargement from a 4x5 copy negative (Original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photographic copy englargement from a 4x5 copy negative (Original photograph by original photographer located on abandoned NASA site, currently owned by the City of Downey, Downey, California). AERIAL PHOTOGRAPH 1935-1936 CONSOLIDATED VULTEE AIRCRAFT CORPORATION FROM WEST TO EAST - NASA Industrial Plant, Maintenance Facility, 12214 Lakewood Boulevard, Downey, Los Angeles County, CA

  3. 22. Photographic copy enlargement from a 4x5 copy negative of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Photographic copy enlargement from a 4x5 copy negative of a print. (Original print located on abandoned NASA site, currently owned by the City of Downey, Downey, California). 1954 USAF PLANT 16 AERIAL BUILDING 41 NORTH TO SOUTH. - NASA Industrial Plant, Missile Research Laboratory, 12214 Lakewood Boulevard, Downey, Los Angeles County, CA

  4. 9. Photographic copy enlargement from a 4x5 copy negative. (Original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Photographic copy enlargement from a 4x5 copy negative. (Original drawing located on abandoned NASA site, currently owned by the City of Downey, Downey, California). 1976 BLDGS.25, 41 SITE PLAN. - NASA Industrial Plant, Storage Facility, 12214 Lakewood Boulevard, Downey, Los Angeles County, CA

  5. 23. Photographic copy enlargement from a 4x5 copy negative of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Photographic copy enlargement from a 4x5 copy negative of a drawing (Original drawing located on abandoned NASA site, currently owned by the City of Downey, Downey, Calfornia). JANUARY 1960 USAF PLANT 16 MASTER PLOT AND GRID PLAN. - NASA Industrial Plant, Missile Research Laboratory, 12214 Lakewood Boulevard, Downey, Los Angeles County, CA

  6. 8. Photographic copy of photograph (from original 4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken May 13, 1942 by unknown photographer. BIRDS-EYE VIEW FROM THE SOUTH OF PRINTING PLANT (STOREHOUSE, BLDG. 85) AT CENTER TOP; STOREHOUSE (BLDG. 88) AT TOP RIGHT; GENERAL PURPOSE ADMINISTRATION BUILDING (BLDG. 90) AT CENTER. - Oakland Army Base, Maritime Street at West Grand Avenue, Oakland, Alameda County, CA

  7. 16. Photographic copy of photograph (from original 4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken prior to June 1942 by unknown photographer. SOUTHWEST BIRDS-EYE VIEW OF WAREHOUSES (BLDGS. 802-805). - Oakland Army Base, Warehouse Type, Tobruk Street, between Warehouse Road & Fifteenth Street, Oakland, Alameda County, CA

  8. 6. Photographic copy of photograph (from original 4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken April 6, 1942 by unknown photographer. SOUTH AND EAST SIDES OBLIQUE VIEW OF PRIVATE VEHICLE INSPECTION BUILDING (VEHICLE SHED, BLDG. 4). - Oakland Army Base, Private Vehicle Inspection Building, Africa Street & Bataan Avenue, Oakland, Alameda County, CA

  9. 11. Photographic copy of photograph (from original 4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken January 31, 1942 by unknown photographer. EAST AND NORTH SIDES OBLIQUE VIEW OF EXCHANGE CAFETERIA (BLDG. 60). - Oakland Army Base, Private Exchange Cafeteria, Bataan Avenue & Attu Street, facing Post Headquarters Building, Oakland, Alameda County, CA

  10. 7. Photographic copy of photograph (from original 4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken January 28, 1942 by unknown photographer. AT CENTER RIGHT, SOUTH AND EAST SIDES OBLIQUE VIEW OF POST HEADQUARTERS BUILDING (ADMINISTRATION BUILDING, BLDG. 1) TAKEN FROM EAST SIDE OF MARITIME STREET. - Oakland Army Base, Maritime Street at West Grand Avenue, Oakland, Alameda County, CA

  11. 7. Photographic copy (reduced to 4 x 5 from 8 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy (reduced to 4 x 5 from 8 X 10 black and white paper reproduction in 1941 appraisal by E.E. Malloy at the Engineering Office, Oakland Army Base, California). Photograph taken between June 1940 and January 1941 by unknown photographer. PARTIAL SOUTH ELEVATION OF VEHICLE MAINTENANCE SHOP (BLDG. 99). - Oakland Army Base, Vehicle Maintenance Shop, Attu Street & Corregidor Avenue, Oakland, Alameda County, CA

  12. 9. NORTH AND WEST ELEVATIONS (4 x 5 NEGATIVE) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. NORTH AND WEST ELEVATIONS (4 x 5 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  13. 9. (5 X 7 enlargement from 4 X 5 negative) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. (5 X 7 enlargement from 4 X 5 negative) FIRST FLOOR, WINDOW MOLDING ON SOUTH WALL LOOKING SOUTH - Sites Homestead, Monongahela National Forest (Tract 390) East of Route 28, Seneca Rocks, Pendleton County, WV

  14. Credit WCT. Original 4" x 5" black and white negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 4" x 5" black and white negative is housed in the JPL Archives, Pasadena, California. This view shows the original furnace for burning scrap propellant, the surrounding incinerator pit, and the earth mound personnel shield (JPL negative no. 381-2737, 11 February 1963) - Jet Propulsion Laboratory Edwards Facility, Incinerator, Edwards Air Force Base, Boron, Kern County, CA

  15. 2. 8' x 10' enlargement from 4' x 5' negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. 8' x 10' enlargement from 4' x 5' negative Kevin Kriesel-Coons, Photographer, November 13, 1990 INTERIOR OF HYDRO PLANT, SHOWING CURRENT STATE OF DISREPAIR. - Crosscut Steam Plant, Ancillary Hydro Unit, North side Salt River near Mill Avenue & Washington Street, Tempe, Maricopa County, AZ

  16. 1. 8' x 10' enlargement from 4' x 5' negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. 8' x 10' enlargement from 4' x 5' negative Kevin Kriesel-Coons, Photographer, November 13, 1990 EXTERIOR OF HYDRO PLANT, SHOWING CURRENT STATE OF DISREPAIR. VIEW FROM WALKWAY OVER TAILRACE OF CROSSCUT CANAL TO THE LARGER, ORIGINAL CROSSCUT HYDRO PLANT. - Crosscut Steam Plant, Ancillary Hydro Unit, North side Salt River near Mill Avenue & Washington Street, Tempe, Maricopa County, AZ

  17. 9. 8' X 10' Enlargement from 4' x 5' negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. 8' X 10' Enlargement from 4' x 5' negative Kevin Kriesel-Coons, Photographer PUMPS AFTER REMOVAL FROM PUMPHOUSE BEFORE EXCAVATION OF POND AREA IN 1989. PHOTOGRAPHED LYING ON GROUND NEAR CROSSCUT STEAM PLANT BUILDING. - Crosscut Steam Plant, Indian Bend Pond & Pump Ditch, North side Salt River near Mill Avenue & Washington Street, Tempe, Maricopa County, AZ

  18. 17. DETAIL, ROOF STRUCTURE (4 x 5 NEGATIVE) U.S. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. DETAIL, ROOF STRUCTURE (4 x 5 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  19. 19. (4"X5" image enlarged from 2 1/4" negative) Sam Fowler, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. (4"X5" image enlarged from 2 1/4" negative) Sam Fowler, Photographer, February 1998 VIEW OF GEORGIA DOT BRIDGE NO. 051-00025D-01986N (JAMES P. HOULIHAN BRIDGE). NAVIGATIONAL LIGHT LOCATED ON TOP OF FENDER - Georgia DOT Bridge No. 051-00025D-01986N, US 17 & State Route 25 Spanning Savannah River, Port Wentworth, Chatham County, GA

  20. 16. Photocopy of drawing enlarged from a 4x5 negative (from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photocopy of drawing enlarged from a 4x5 negative (from Cultural Resources plan files, Gateway National Recreation Area, New Jersey) U.S. Army Corps of Engineers, Designers, 1909 PLAN OF DRAINAGE AND ELECTRICAL SYSTEM OF BATTERY - Fort Hancock, Battery George Arrowsmith, Southwest edge of Sandy Point extending to Horseshoe Cove, Fort Hancock, Monmouth County, NJ

  1. 3. Credit WCT. Original 4"x5" black and white negative is ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Credit WCT. Original 4"x5" black and white negative is housed in the JPL Archives, Pasadena, California. This view of the vibrator shows a large mounted ATS (Advanced Technology Satellite) motor. Accelerometer instrumentation has been added. JPL caption reads "C-210E Vibration Exciter ATS Accelerometer Installation on Q4TX AXIS" (JPL negative no. 384-5848B, 31 March 1966). - Jet Propulsion Laboratory Edwards Facility, Test Stand G, Edwards Air Force Base, Boron, Kern County, CA

  2. Credit WCT. Original 4"x5" black and white negative is housed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 4"x5" black and white negative is housed in the JPL Archives, Pasadena, California. This view shows the underfloor ductwork of Building E-46 during construction. The ductwork conducts hot or cold air to maintain required temperatures in the curing chamber (JPL negative no. 381-2569, 12 December 1962) - Jet Propulsion Laboratory Edwards Facility, Solid Propellant Conditioning Building, Edwards Air Force Base, Boron, Kern County, CA

  3. Credit WCT. Original 4"x5" black and white negative is housed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 4"x5" black and white negative is housed in the JPL Archives, Pasadena, California. This view shows Building E-39 under construction. E-39 is an example of the typical reinforced concrete block construction of the E-30s and E-40s structures (JPL negative no. 381-2586, 13 December 1962) - Jet Propulsion Laboratory Edwards Facility, Propellant Curing Building, Edwards Air Force Base, Boron, Kern County, CA

  4. 18. (4"X5" image enlarged from 2 1/4" negative) Sam Fowler, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. (4"X5" image enlarged from 2 1/4" negative) Sam Fowler, Photographer, February 1998 VIEW OF GEORGIA DOT BRIDGE NO. 051-00025D-01986N (JAMES P. HOULIHAN BRIDGE) APPROACH SPAN FENDER. DOLPHIN LOCATED AT RIGHT. NAVIGATIONAL LIGHT LOCATED ON TOP OF FENDER - Georgia DOT Bridge No. 051-00025D-01986N, US 17 & State Route 25 Spanning Savannah River, Port Wentworth, Chatham County, GA

  5. Credit WCT. Original 4"x5" black and white negative is housed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 4"x5" black and white negative is housed in the JPL Archives, Pasadena, California. This image shows the tumble dryer in place as building construction neared completion. The mezzanine railings have not been installed. The scattered debris on the floor and stairs would not be allowed during dryer operation. Compare this view with CA-163-Q-2 and note that the stairs in this 1963 view were moved later; the screen wall was also removed. The reasons for these alterations were not determined (JPL negative no. 381-2831, 18 March 1963) - Jet Propulsion Laboratory Edwards Facility, Oxidizer Dryer Building, Edwards Air Force Base, Boron, Kern County, CA

  6. 19. Print from copy negative (original glass plate negative in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Print from copy negative (original glass plate negative in Tippecanoe County Historical Society.) Original photo dated May 7, 1893. View north, south side. - Big Four Depot, 10 South Second Street, Lafayette, Tippecanoe County, IN

  7. 20. INTERIOR, COAL CHUTES (G.S.A. PHOTOCOPY, N.D.) (4 x 5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. INTERIOR, COAL CHUTES (G.S.A. PHOTOCOPY, N.D.) (4 x 5 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  8. 4. Credit JPL. Original 4" x 5" black and white ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Credit JPL. Original 4" x 5" black and white negative housed in the JPL Archives, Pasadena, California. This interior view displays the machine shop in the Administration/Shops Building (the compass angle of the view is undetermined). Looking clockwise from the lower left, the machine tools in view are a power hacksaw, a heat-treatment oven (with white gloves on top), a large hydraulic press with a tool grinder at its immediate right; along the wall in the back of the view are various unidentified machine tool attachments and a vertical milling machine. In the background, a machinist is operating a radial drilling machine, to the right of which is a small drill press. To the lower right, another machinist is operating a Pratt & Whitney engine lathe; behind the operator stand a workbench and vertical bandsaw (JPL negative no. 384-10939, 29 July 1975). - Jet Propulsion Laboratory Edwards Facility, Administration & Shops Building, Edwards Air Force Base, Boron, Kern County, CA

  9. 19. CHAPMAN ROAD LOOKING NORTH (Buildings 43, 42) (Copy negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. CHAPMAN ROAD LOOKING NORTH (Buildings 43, 42) (Copy negative made from National Archives negative No. 92-F-61B-4) - Fort Sheridan, 25 miles Northeast of Chicago, on Lake Michigan, Lake Forest, Lake County, IL

  10. 4. Photocopy of photograph (4 x 5 inch enlargement of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Photocopy of photograph (4 x 5 inch enlargement of 1942 3-1/2 x 5-7/8 inch print by R. Fromme; in Recreation files, Supervisor's Office, Mt. Baker-Snoqualmie National Forest) EAST (MAIN) ELEVATION OF PROTECTION ASSISTANT'S RESIDENCE - Glacier Ranger Station, Protection Assistant's Residence, Washington State Route 542, Glacier, Whatcom County, WA

  11. 23. Photocopy of photograph (4 x 5 inch enlargement of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Photocopy of photograph (4 x 5 inch enlargement of 1940 3-1/4 x 4-1/4 inch print by R. Nevan McCullough; in Cultural Resource files, Supervisor's Office, Mt. Baker-Snoqualmie National Forest) SOUTH FRONT - Suntop Lookout, Forest Road 510, Mt. Baker-Snoqualmie National Forest, Greenwater, Pierce County, WA

  12. 14. Photocopy of photograph (4 x 5 inch reduction of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of photograph (4 x 5 inch reduction of 1939 3-5/8 x 6 inch print by R. Fromme; in Recreation files, Supervisor's Office, Mt. Baker-Snoqualmie National Forest) ENTRANCE TO GLACIER RANGER STATION, FROM WEST. GARAGE AND STORAGE BUILDING IN LEFT BACKGROUND. - Glacier Ranger Station, Washington State Route 542, Glacier, Whatcom County, WA

  13. 21. Print from copy negative of postcard ca. 1910. (Original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Print from copy negative of postcard ca. 1910. (Original in Tippecanoe County Historical Society.) View southeast, northwest side. - Big Four Depot, 10 South Second Street, Lafayette, Tippecanoe County, IN

  14. 20. Print from copy negative of post card ca. 1910. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Print from copy negative of post card ca. 1910. (Original in Tippecanoe County Historical Society.) View northeast, south side. - Big Four Depot, 10 South Second Street, Lafayette, Tippecanoe County, IN

  15. 5. Historic American Buildings Survey COPY OF OLD (UNDATED) NEGATIVE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey COPY OF OLD (UNDATED) NEGATIVE, UNITED STATES COAST GUARD DISTRICT OFFICE 427 COMMERCIAL STREET, BOSTON, MASSACHUSETTS - Portland Breakwater Lighthouse, Northeast end of Portland Breakwater, Portland Harbor, South Portland, Cumberland County, ME

  16. 3. Photographic copy of photograph (ca. 1955, original negative found ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photographic copy of photograph (ca. 1955, original negative found in Beierle Barn, now on file at New Denver International Airport Office, Stapleton International Ariport, Denver, CO). VIEW OF RESIDENCE AND FARM, LOOKING NORTHEAST. - Beierle Farm, Hudson Road & Ninety-Sixth Avenue, Denver, Denver County, CO

  17. Copy Photograph (original negative in possession of LSA Associates, Irvine, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Copy Photograph (original negative in possession of LSA Associates, Irvine, California) Beth Padon, Photographer, 1985 BOYD FARMSTEAD, LOOKING NORTHEAST, GARAGE, HOUSE, RAILROAD CAR PRESENT IN 1985 BUT REMOVED BY JANUARY 1989 - Irvine Ranch Agricultural Headquarters, Boyd Tenant House, Southeast of Intersection of San Diego & Santa Ana Freeways, Irvine, Orange County, CA

  18. Copy Photograph (original negative in possession of LSA Associates, Irvine, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Copy Photograph (original negative in possession of LSA Associates, Irvine, California) Beth Padon, Photographer, 1985 BOYD FARMSTEAD IN RELATION TO I-5, LOOKING SOUTHWEST - Irvine Ranch Agricultural Headquarters, Boyd Tenant House, Southeast of Intersection of San Diego & Santa Ana Freeways, Irvine, Orange County, CA

  19. Copy Photograph (original negative in possession of LSA Associates, Irvine, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Copy Photograph (original negative in possession of LSA Associates, Irvine, California) Beth Padon, Photographer, 1985 MACHINE AND CHEMICAL STORAGE BUILDING, NORTH (FRONT), LOOKING SOUTH - Irvine Ranch Agricultural Headquarters, Boyd Tenant House, Southeast of Intersection of San Diego & Santa Ana Freeways, Irvine, Orange County, CA

  20. Copy Photograph (original negative in possession of LSA Associates, Irvine, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Copy Photograph (original negative in possession of LSA Associates, Irvine, California) Rebecca Conard, Photographer, January 1989 STORAGE SHED, WEST (FRONT), LOOKING EAST - Irvine Ranch Agricultural Headquarters, Boyd Tenant House, Southeast of Intersection of San Diego & Santa Ana Freeways, Irvine, Orange County, CA

  1. Copy Photograph (original negative in possession of LSA Associates, Irvine, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Copy Photograph (original negative in possession of LSA Associates, Irvine, California) Beth Padon, Photographer, 1985 BOYD FARMSTEAD, LOOKING SOUTHEAST, WATER TANK, HOUSE, GARAGE - Irvine Ranch Agricultural Headquarters, Boyd Tenant House, Southeast of Intersection of San Diego & Santa Ana Freeways, Irvine, Orange County, CA

  2. 4. Photographic copy of a photograph taken from pasteup negatives ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Photographic copy of a photograph taken from paste-up negatives for U.S. Army Corps of Engineers document GF-500-MCP, entitled "Grand Forks Site RLS Army Operating Drawings, Master Composite Photographs for SAFEGUARD TSE Systems and Equipment," Page 9, dated 1 September 1974 (original document and negatives in possession of U.S. Army Corps of Engineers, Huntsville, AL). Photographer unknown. View of remote launch operations building exterior (southwest corner), prior to earth mounding. A,B,C, and D are heat exchangers HX-1102B, HX-1102A, HX-1101B, and HX-1101 A, respectively. The heat exchangers transferred heat from the cooling water to the outside air during the normal operating mode. On the far right is the air exhaust shaft - Stanley R. Mickelsen Safeguard Complex, Remote Launch Operations Building, Near Service Road exit from Patrol Road, Nekoma, Cavalier County, ND

  3. 5. Photographic copy of a photograph taken from pasteup negatives ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Photographic copy of a photograph taken from paste-up negatives for U.S. Army Corps of Engineers document GF-500-MCP, entitled "Grand Forks Site RLS Army Operating Drawings, Master Composite Photographs for SAFEGUARD TSE Systems and Equipment," Page 9, dated 1 September 1974 (original document and negatives in possession of U.S. Army Corps of Engineers, Huntsville, AL). Photographer unknown. View of pneumatic control panel regulating entrance to waiting room #116. The panel activated the pneumatic cylinder for opening and closing of blast doors #116 and #118. A rotary air motor actuated locking and unlocking of the doors. - Stanley R. Mickelsen Safeguard Complex, Remote Launch Operations Building, Near Service Road exit from Patrol Road, Nekoma, Cavalier County, ND

  4. 6. Photographic copy of a photograph taken from pasteup negatives ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photographic copy of a photograph taken from paste-up negatives for U.S. Army Corps of Engineers document GF-500-MCP, entitled "Grand Forks Site RLS Army Operating Drawings, Master Composite Photographs for SAFEGUARD TSE Systems and Equipment," Page 9, dated 1 September 1974 (original document and negatives in possession of U.S. Army Corps of Engineers, Huntsville, AL). Photographer unknown. View of remote launch operations building, power generation room #124, showing no-break units NB-1002 (A) and NB-1001 (B). This equipment consisted of a 150 horsepower, d.c. operational motor which drove, on each end of the extended shaft, a 70 kw generator and a 30 kw generator unit. It was designed to provide continuous power service for launch equipment. In particular, the photo is an excellent representation of the shock isolation scheme, as evidenced by the supporting air springs and equipment platform - Stanley R. Mickelsen Safeguard Complex, Remote Launch Operations Building, Near Service Road exit from Patrol Road, Nekoma, Cavalier County, ND

  5. 4. Photographic copy of map. San Carlos Irrigation Project, Gila ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Photographic copy of map. San Carlos Irrigation Project, Gila River Indian Reservation, Pinal County, Arizona. Department of the Interior. Office of Indian Affairs. 1940. (Source: SCIP Office, Coolidge, AZ) Photograph is an 8'x10' enlargement from a 4'x5' negative. - San Carlos Irrigation Project, Lands North & South of Gila River, Coolidge, Pinal County, AZ

  6. 1. Photographic copy of photograph, no date, in possession of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photographic copy of photograph, no date, in possession of Arizona Historical Society Library. Photograph #718. Photographer unknown. BUILDING THE FLORENCE CANAL AND RESERVOIR. Photograph is an 8'x10' enlargement from a 4'x5' negative. - San Carlos Irrigation Project, Florence Canal, South of Gila River, Coolidge, Pinal County, AZ

  7. 2. Photographic copy of photograph, undated, in possession of Arizona ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photographic copy of photograph, undated, in possession of Arizona Historical Society. Photograph #793. Photographer unknown. BUILDING FLORENCE RESERVOIR (PRESUMABLY PICACHO RESERVOIR) Photograph is an 8'x10' enlargement from a 4'x5' negative. - San Carlos Irrigation Project, Picacho Resevoir, South of Gila River, Coolidge, Pinal County, AZ

  8. 32. PORT PROFILE OF THE ALABAMA. Uncopyrighted 31/4'x5'photograph taken by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. PORT PROFILE OF THE ALABAMA. Uncopyrighted 3-1/4'x5'photograph taken by Thigpen Photography, c. 1965. Written on back of photo: 'This is what the vessel looked like when I bought her in 1966 R.S. Douglas.' Also, stamped on back is: Thigpen Photography 1442 So. Beltline Highway Mobile, Alabama 46609 to reorder specify no. M7062-1 - Pilot Schooner "Alabama", Moored in harbor at Vineyard Haven, Vineyard Haven, Dukes County, MA

  9. Negative public information in mate choice copying helps the spread of a novel trait.

    PubMed

    Santos, Mauro; Matos, Margarida; Varela, Susana A M

    2014-11-01

    Numerous field and laboratory experiments have shown that many species have the capacity for social learning, including mate choice decisions that can be influenced by witnessing the mating decisions of others. Here we develop a numerical model of mate choice copying that follows the population genetics tradition, consisting in tracking allele frequencies in a population over time under various scenarios. In contrast to previous evolutionary models, we consider both positive social information and negative social information because many mating systems are driven by males in pursuit of a mate and female refusal of copulation may provide negative social information. The inclusion of negative social information to mate choice copying helps the spread of a novel trait, even if female innate mate choice preference is biased toward the common male type. We argue that the presence or absence of copying might simply mirror the associated cost-benefit relationship of the mating system of a given species and suggest how to test this prediction.

  10. 2. Photographic copy of map. Gila River Project, General Map ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photographic copy of map. Gila River Project, General Map Showing Progress for the Fiscal Year 1927. (Source: U.S. Department of Interior. Office of Indian Affairs. Indian Irrigation Service. Annual Report, Fiscal Year 1927. Vol. I, Narrative and Photographs, District #4, RG 75, Entry 655, Box 29, National Archives, Washington, DC.) Photograph is an 8'x10' enlargement from a 4'x5' negative. - San Carlos Irrigation Project, Lands North & South of Gila River, Coolidge, Pinal County, AZ

  11. 1. Copy photo of context view taken in 1917 looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Copy photo of context view taken in 1917 looking east along Farragut Avenue, then called Main Street, showing construction of double tracking. On right is Building 78 with original smoke stack. Building 59 is visible as third building from left. This photograph was taken from a hill that was later cut away in order to expand the shipyard. See photo for original caption. HABS negative is a 4x5' copy negative made from a print in the collection of the Photographic Branch, Puget Sound Naval Shipyard, Bremerton, WA. Photographer unknown. - Puget Sound Naval Shipyard, Administration Building, Farragut Avenue, Bremerton, Kitsap County, WA

  12. High frequency of copy number imbalances in Rubinstein–Taybi patients negative to CREBBP mutational analysis

    PubMed Central

    Gervasini, Cristina; Mottadelli, Federica; Ciccone, Roberto; Castronovo, Paola; Milani, Donatella; Scarano, Gioacchino; Bedeschi, Maria Francesca; Belli, Serena; Pilotta, Alba; Selicorni, Angelo; Zuffardi, Orsetta; Larizza, Lidia

    2010-01-01

    Rubinstein–Taybi syndrome (RSTS) is a rare autosomal dominant disorder characterised by facial dysmorphisms, growth and psychomotor development delay, and skeletal defects. The known genetic causes are point mutations or deletions of the CREBBP (50–60%) and EP300 (5%) genes. To detect chromosomal rearrangements indicating novel positional candidate RSTS genes, we used a-CGH to study 26 patients fulfilling the diagnostic criteria for RSTS who were negative at fluorescence in situ hybridisation analyses of the CREBBP and EP300 regions, and direct sequencing analyses of the CREBBP gene. We found seven imbalances (27%): four de novo and three inherited rearrangements not reported among the copy number variants. A de novo 7p21.1 deletion of 500 kb included the TWIST1 gene, a suggested candidate for RSTS that is responsible for the Saethre–Chotzen syndrome, an entity that enters in differential diagnosis with RSTS. A similar issue of differential diagnosis was raised by a large 4.3 Mb 2q22.3q23.1 deletion encompassing ZEB2, the gene responsible for the Mowat–Wilson syndrome, whose signs may overlap with RSTS. Positional candidate genes could not be sought in the remaining pathogenetic imbalances, because of the size of the involved region (a 9 Mb 2q24.3q31.1 deletion) and/or the relative paucity of suitable genes (a 5 Mb 3p13p12.3 duplication). One of the inherited rearrangements, the 17q11.2 379Kb duplication, represents the reciprocal event of the deletion underlying an overgrowth syndrome, both being mediated by the NF1-REP-P1 and REP-P2 sub-duplicons. The contribution of this and the other detected CNVs to the clinical RSTS phenotype is difficult to assess. PMID:20125191

  13. Genome-Wide Loss of Heterozygosity and DNA Copy Number Aberration in HPV-Negative Oral Squamous Cell Carcinoma and Their Associations with Disease-Specific Survival.

    PubMed

    Chen, Chu; Zhang, Yuzheng; Loomis, Melissa M; Upton, Melissa P; Lohavanichbutr, Pawadee; Houck, John R; Doody, David R; Mendez, Eduardo; Futran, Neal; Schwartz, Stephen M; Wang, Pei

    2015-01-01

    Oral squamous cell cancer of the oral cavity and oropharynx (OSCC) is associated with high case-fatality. For reasons that are largely unknown, patients with the same clinical and pathologic staging have heterogeneous response to treatment and different probability of recurrence and survival, with patients with Human Papillomavirus (HPV)-positive oropharyngeal tumors having the most favorable survival. To gain insight into the complexity of OSCC and to identify potential chromosomal changes that may be associated with OSCC mortality, we used Affymtrix 6.0 SNP arrays to examine paired DNA from peripheral blood and tumor cell populations isolated by laser capture microdissection to assess genome-wide loss of heterozygosity (LOH) and DNA copy number aberration (CNA) and their associations with risk factors, tumor characteristics, and oral cancer-specific mortality among 75 patients with HPV-negative OSCC. We found a highly heterogeneous and complex genomic landscape of HPV-negative tumors, and identified regions in 4q, 8p, 9p and 11q that seem to play an important role in oral cancer biology and survival from this disease. If confirmed, these findings could assist in designing personalized treatment or in the creation of models to predict survival in patients with HPV-negative OSCC.

  14. Genome-Wide Loss of Heterozygosity and DNA Copy Number Aberration in HPV-Negative Oral Squamous Cell Carcinoma and Their Associations with Disease-Specific Survival.

    PubMed

    Chen, Chu; Zhang, Yuzheng; Loomis, Melissa M; Upton, Melissa P; Lohavanichbutr, Pawadee; Houck, John R; Doody, David R; Mendez, Eduardo; Futran, Neal; Schwartz, Stephen M; Wang, Pei

    2015-01-01

    Oral squamous cell cancer of the oral cavity and oropharynx (OSCC) is associated with high case-fatality. For reasons that are largely unknown, patients with the same clinical and pathologic staging have heterogeneous response to treatment and different probability of recurrence and survival, with patients with Human Papillomavirus (HPV)-positive oropharyngeal tumors having the most favorable survival. To gain insight into the complexity of OSCC and to identify potential chromosomal changes that may be associated with OSCC mortality, we used Affymtrix 6.0 SNP arrays to examine paired DNA from peripheral blood and tumor cell populations isolated by laser capture microdissection to assess genome-wide loss of heterozygosity (LOH) and DNA copy number aberration (CNA) and their associations with risk factors, tumor characteristics, and oral cancer-specific mortality among 75 patients with HPV-negative OSCC. We found a highly heterogeneous and complex genomic landscape of HPV-negative tumors, and identified regions in 4q, 8p, 9p and 11q that seem to play an important role in oral cancer biology and survival from this disease. If confirmed, these findings could assist in designing personalized treatment or in the creation of models to predict survival in patients with HPV-negative OSCC. PMID:26247464

  15. Genome-Wide Loss of Heterozygosity and DNA Copy Number Aberration in HPV-Negative Oral Squamous Cell Carcinoma and Their Associations with Disease-Specific Survival

    PubMed Central

    Chen, Chu; Zhang, Yuzheng; Loomis, Melissa M.; Upton, Melissa P.; Lohavanichbutr, Pawadee; Houck, John R.; Doody, David R.; Mendez, Eduardo; Futran, Neal; Schwartz, Stephen M.; Wang, Pei

    2015-01-01

    Oral squamous cell cancer of the oral cavity and oropharynx (OSCC) is associated with high case-fatality. For reasons that are largely unknown, patients with the same clinical and pathologic staging have heterogeneous response to treatment and different probability of recurrence and survival, with patients with Human Papillomavirus (HPV)-positive oropharyngeal tumors having the most favorable survival. To gain insight into the complexity of OSCC and to identify potential chromosomal changes that may be associated with OSCC mortality, we used Affymtrix 6.0 SNP arrays to examine paired DNA from peripheral blood and tumor cell populations isolated by laser capture microdissection to assess genome-wide loss of heterozygosity (LOH) and DNA copy number aberration (CNA) and their associations with risk factors, tumor characteristics, and oral cancer-specific mortality among 75 patients with HPV-negative OSCC. We found a highly heterogeneous and complex genomic landscape of HPV-negative tumors, and identified regions in 4q, 8p, 9p and 11q that seem to play an important role in oral cancer biology and survival from this disease. If confirmed, these findings could assist in designing personalized treatment or in the creation of models to predict survival in patients with HPV-negative OSCC. PMID:26247464

  16. PCR-Based Simple Subgrouping Is Validated for Classification of Gliomas and Defines Negative Prognostic Copy Number Aberrations in IDH Mutant Gliomas

    PubMed Central

    Nakae, Shunsuke; Sasaki, Hikaru; Hayashi, Saeko; Hattori, Natsuki; Kumon, Masanobu; Nishiyama, Yuya; Adachi, Kazuhide; Nagahisa, Shinya; Hayashi, Takuro; Inamasu, Joji; Abe, Masato; Hasegawa, Mitsuhiro; Hirose, Yuichi

    2015-01-01

    Genetic subgrouping of gliomas has been emphasized recently, particularly after the finding of isocitrate dehydrogenase 1 (IDH1) mutations. In a previous study, we investigated whole-chromosome copy number aberrations (CNAs) of gliomas and have described genetic subgrouping based on CNAs and IDH1 mutations. Subsequently, we classified gliomas using simple polymerase chain reaction (PCR)-based methods to improve the availability of genetic subgrouping. We selected IDH1/2 and TP53 as markers and analyzed 237 adult supratentorial gliomas using Sanger sequencing. Using these markers, we classified gliomas into three subgroups that were strongly associated with patient prognoses. These included IDH mutant gliomas without TP53 mutations, IDH mutant gliomas with TP53 mutations, and IDH wild-type gliomas. IDH mutant gliomas without TP53 mutations, which mostly corresponded to gliomas carrying 1p19q co-deletions, showed lower recurrence rates than the other 2 groups. In the other high-recurrence groups, the median progression-free survival (PFS) and overall survival (OS) of patients with IDH mutant gliomas with TP53 mutations were significantly longer than those of patients with IDH wild-type gliomas. Notably, most IDH mutant gliomas with TP53 mutations had at least one of the CNAs +7q, +8q, −9p, and −11p. Moreover, IDH mutant gliomas with at least one of these CNAs had a significantly worse prognosis than did other IDH mutant gliomas. PCR-based mutation analyses of IDH and TP53 were sufficient for simple genetic diagnosis of glioma that were strongly associated with prognosis of patients and enabled us to detect negative CNAs in IDH mutant gliomas. PMID:26558387

  17. Copy number variation in the region harboring SOX9 gene in dogs with testicular/ovotesticular disorder of sex development (78,XX; SRY-negative).

    PubMed

    Marcinkowska-Swojak, Malgorzata; Szczerbal, Izabela; Pausch, Hubert; Nowacka-Woszuk, Joanna; Flisikowski, Krzysztof; Dzimira, Stanislaw; Nizanski, Wojciech; Payan-Carreira, Rita; Fries, Ruedi; Kozlowski, Piotr; Switonski, Marek

    2015-01-01

    Although the disorder of sex development in dogs with female karyotype (XX DSD) is quite common, its molecular basis is still unclear. Among mutations underlying XX DSD in mammals are duplication of a long sequence upstream of the SOX9 gene (RevSex) and duplication of the SOX9 gene (also observed in dogs). We performed a comparative analysis of 16 XX DSD and 30 control female dogs, using FISH and MLPA approaches. Our study was focused on a region harboring SOX9 and a region orthologous to the human RevSex (CanRevSex), which was located by in silico analysis downstream of SOX9. Two highly polymorphic copy number variable regions (CNVRs): CNVR1 upstream of SOX9 and CNVR2 encompassing CanRevSex were identified. Although none of the detected copy number variants were specific to either affected or control animals, we observed that the average number of copies in CNVR1 was higher in XX DSD. No copy variation of SOX9 was observed. Our extensive studies have excluded duplication of SOX9 as the common cause of XX DSD in analyzed samples. However, it remains possible that the causative mutation is hidden in highly polymorphic CNVR1. PMID:26423656

  18. Copy number variation in the region harboring SOX9 gene in dogs with testicular/ovotesticular disorder of sex development (78,XX; SRY-negative).

    PubMed

    Marcinkowska-Swojak, Malgorzata; Szczerbal, Izabela; Pausch, Hubert; Nowacka-Woszuk, Joanna; Flisikowski, Krzysztof; Dzimira, Stanislaw; Nizanski, Wojciech; Payan-Carreira, Rita; Fries, Ruedi; Kozlowski, Piotr; Switonski, Marek

    2015-01-01

    Although the disorder of sex development in dogs with female karyotype (XX DSD) is quite common, its molecular basis is still unclear. Among mutations underlying XX DSD in mammals are duplication of a long sequence upstream of the SOX9 gene (RevSex) and duplication of the SOX9 gene (also observed in dogs). We performed a comparative analysis of 16 XX DSD and 30 control female dogs, using FISH and MLPA approaches. Our study was focused on a region harboring SOX9 and a region orthologous to the human RevSex (CanRevSex), which was located by in silico analysis downstream of SOX9. Two highly polymorphic copy number variable regions (CNVRs): CNVR1 upstream of SOX9 and CNVR2 encompassing CanRevSex were identified. Although none of the detected copy number variants were specific to either affected or control animals, we observed that the average number of copies in CNVR1 was higher in XX DSD. No copy variation of SOX9 was observed. Our extensive studies have excluded duplication of SOX9 as the common cause of XX DSD in analyzed samples. However, it remains possible that the causative mutation is hidden in highly polymorphic CNVR1.

  19. Copy number variation in the region harboring SOX9 gene in dogs with testicular/ovotesticular disorder of sex development (78,XX; SRY-negative)

    PubMed Central

    Marcinkowska-Swojak, Malgorzata; Szczerbal, Izabela; Pausch, Hubert; Nowacka-Woszuk, Joanna; Flisikowski, Krzysztof; Dzimira, Stanislaw; Nizanski, Wojciech; Payan-Carreira, Rita; Fries, Ruedi; Kozlowski, Piotr; Switonski, Marek

    2015-01-01

    Although the disorder of sex development in dogs with female karyotype (XX DSD) is quite common, its molecular basis is still unclear. Among mutations underlying XX DSD in mammals are duplication of a long sequence upstream of the SOX9 gene (RevSex) and duplication of the SOX9 gene (also observed in dogs). We performed a comparative analysis of 16 XX DSD and 30 control female dogs, using FISH and MLPA approaches. Our study was focused on a region harboring SOX9 and a region orthologous to the human RevSex (CanRevSex), which was located by in silico analysis downstream of SOX9. Two highly polymorphic copy number variable regions (CNVRs): CNVR1 upstream of SOX9 and CNVR2 encompassing CanRevSex were identified. Although none of the detected copy number variants were specific to either affected or control animals, we observed that the average number of copies in CNVR1 was higher in XX DSD. No copy variation of SOX9 was observed. Our extensive studies have excluded duplication of SOX9 as the common cause of XX DSD in analyzed samples. However, it remains possible that the causative mutation is hidden in highly polymorphic CNVR1. PMID:26423656

  20. Chromosome numbers, characterization of chromosomal pairing during meiosis, origin and natural propagation in polyploid cytotypes (4x, 5x and 6x) of Agrimonia eupatoria L. (Rosaceae) in northwest Himalayas (India).

    PubMed

    Kumar, Puneet; Rana, Pawan K; Himshikha; Singhal, Vijay Kumar; Gupta, R C

    2014-07-01

    Despite the presence of intraspecific polyploidy (2x, 4x, 5x and 6x) in Agrimonia eupatoria, origin of these cytotypes has never been addressed adequately. The aim of the present study was to record the original chromosome counts and characterize chromosomal pairing during meiosis and microsporogenesis in the 5x cytotype, and discussing the hypothesis regarding the possible origin of polyploid cytotypes (4x, 5x and 6x) in the species. The geographical distribution pattern of cytotypes in the Indian Himalayas and elsewhere has also been analyzed. The present meiotic analysis revealed three chromosomes counts, the tetraploid (2n = 4x = 56), the pentaploid (2n = 5x = 70) and the hexaploid (2n = 6x = 84) cytotypes based on x = 14. Meiotic course was perfectly normal in the 4x and 6x cytotypes resulting into high pollen fertility (94-100 %). Meiotic course in the imbalanced 5x cytotype has been found to be irregular characterized by the presence of high frequency of univalents at diakinesis and metaphase-I. Abnormal meiotic course contributed towards high pollen sterility (74-88 %). Even the apparently fertile/stained pollen grains were of irregular shape and of heterogeneous sizes. Meiotic behaviour of the 5x cytotype is like typical of allopolyploid. Individuals of 5x cytotype did not produce seeds and propagate vegetatively (root suckers) while 4x and 6x cytotypes exploited sexual (seeds) as well as vegetative means for propagation. Chromosomal pairing in pentaploid cytotype is like typical of an allopolyploid and we assume that it might have originated owing to natural inter-cytotype hybridization between 4x and 6x cytotypes in a mixed population. Analysis of geographical distribution pattern of cytotypes shows that Indian Himalayas represent the most cytotype-diverse region for A. eupatoria with the existence of all the four cytotypes (2x, 4x, 5x, 6x). This shows the dynamic nature of the species at chromosomal level in this part of the world.

  1. Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection

    PubMed Central

    Rhie, Arang; Park, Weon Seo; Choi, Moon Kyung; Kim, Ji-Hyun; Ryu, Junsun; Ryu, Chang Hwan; Kim, Jong-Il; Jung, Yuh-Seog

    2015-01-01

    Abstract Recently increasing high-risk HPV+ OSCC exhibits unique clinical and molecular characteristics compared to HPV-unrelated (HPV−) counterpart. Genomic copy number variations (CNVs), unique in HPV+ OSCCs, and their role for the prognosis prediction remains poorly studied. Here, we analyzed the distinct genomic copy number variations (CNVs) in human papillomavirus-related (HPV+) oropharyngeal squamous cell carcinoma (OSCC) and their role as a prognosticator after curative resection. For 58 consecutive, Korean OSCC patients that underwent surgery-based treatment with median 10 years of follow-up, HPV-related markers, and genome-wide CNV analysis were analyzed. Clinical associations between the CNV profile and survival analyses were followed. p16 expression predicted the overall survival (OS) (hazard ratio [HR] = 0.27, confidence interval [CI]: 0.39–0.80, P = 0.0006) better than HPV L1 PCR (HR = 0.83, CI: 0.66–1.29, P = 0.64), smoking, or other variables. Although the overall number of CNVs was not significantly different, 30 loci showed unique CNV patterns between the p16+ and p16− groups. A region containing PRDM2 was amplified only in the p16+ group, whereas EGFR and 11q13.3 showed increased amplification in p16− counterpart. Loss of a locus containing FGF18 led to a worse, but gain of region including CDK10 and RAD18 led to better overall survival (OS) in all OSCC patients. Meanwhile, subgroup analysis of p16+ OSCC revealed that amplification of regions harboring HRAS and loss of locus bearing KDR led to better OS. p16+ OSCC exhibit distinct CNV patterns compared with p16− counterpart. Specific patterns of CNVs predict better survival, especially in p16+ OSCC. This might allow better insights of the outcome after curative resection for HPV+ and HPV− OSCC. PMID:26683928

  2. A Rare Case of Testicular Disorder of Sex Development in a Dog (78,XX; SRY-Negative) with Male External Genitalia and Detection of Copy Number Variation in the Region Upstream of the SOX9 Gene.

    PubMed

    Szczerbal, Izabela; Nowacka-Woszuk, Joanna; Dzimira, Stanislaw; Atamaniuk, Wojciech; Nizanski, Wojciech; Switonski, Marek

    2016-01-01

    Testicular or ovotesticular disorder of sex development (DSD) in genetic females (78,XX; SRY-negative) has been reported quite frequently in numerous dog breeds and is usually diagnosed due to the presence of female external genitalia with an enlarged clitoris. The molecular background of this disorder, diagnosed also in human and other mammals, is not fully understood. However, it has recently been proposed that a copy number variation (CNV) in the region upstream of the SOX9 gene is associated with it. We described a rare case of this disorder in a French Bulldog with abdominal testes and male external genitalia (a slightly malformed penis). FISH studies showed a female karyotype, lack of a translocation involving the Y chromosome, and a distinct size variation in the CNV region (CNVR) upstream of the SOX9 gene, located on chromosome 9 (CFA9). A large FISH variant on a single CFA9 and a lack of the variant on its homologue was observed. Surprisingly, in the mother of this DSD dog, 2 normal-sized variants were identified which means that the CNV in the DSD dog was de novo. Our observations are in agreement with earlier suggestions that a high number of copies at the CNVR upstream of SOX9 may be associated with this type of DSD.

  3. 37 CFR 1.13 - Copies and certified copies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Copies and certified copies... Patent and Trademark Office § 1.13 Copies and certified copies. (a) Non-certified copies of patents, and... States Patent and Trademark Office to any person, and copies of other records or papers will be...

  4. 37 CFR 2.201 - Copies and certified copies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Copies and certified copies... Trademark Office § 2.201 Copies and certified copies. (a) Non-certified copies of trademark registrations... appropriate fee required by § 2.6. (b) Certified copies of trademark registrations and of any...

  5. Copy-left and Copy-right

    NASA Astrophysics Data System (ADS)

    VanderPlas, Jacob

    2015-01-01

    Any discussion of open licensing almost invariably devolves into a debate between copy-left licenses and permissive licenses, both sides defending their views with a nearly religious fervor. Copy-left licenses, typified by the GPL family of licenses, require all derived products to maintain the open, GPL license. Permissive licenses, typified by the BSD family of licenses, do not impose such requirements. I'll briefly explore the common arguments put forth in favor of either approach, and discuss some concrete examples of where these approaches have helped or hindered the software packages that used them.

  6. 7 CFR 97.179 - Copies and certified copies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Copies and certified copies. 97.179 Section 97.179... PLANT VARIETY AND PROTECTION Fees and Charges § 97.179 Copies and certified copies. (a) Upon request, copies of applications, certificates, or of any records, books, papers, drawings, or photographs in...

  7. 42. Photographic copy of original construction drawing, dated June 1911 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    42. Photographic copy of original construction drawing, dated June 1911 (from paper-copy of aperture-card negative at Bureau of Reclamation, Pacific Northwest Regional Office, Boise, ID). EAST ELEVATION (EAST SIDE) AND SOUTH ELEVATION (SOUTH SIDE). - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID

  8. 37. Photographic copy of original construction drawing, dated June 1911 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. Photographic copy of original construction drawing, dated June 1911 (from paper-copy of aperture-card negative at Bureau of Reclamation, Pacific Northwest Regional Office, Boise, ID). BASEMENT PLAN. - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID

  9. 40. Photographic copy of original construction drawing, dated June 1911 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    40. Photographic copy of original construction drawing, dated June 1911 (from paper-copy of aperture-card negative at Bureau of Reclamation, Pacific Northwest Regional Office, Boise, ID). ROOF PLAN. - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID

  10. 45. Photographic copy of original construction drawing, dated 16 February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    45. Photographic copy of original construction drawing, dated 16 February 1916 (from paper-copy of aperture-card negative at Bureau of Reclamation, Pacific Northwest Regional Office, Boise, ID). LOT SURVEY. - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID

  11. 41. Photographic copy of original construction drawing, dated June 1911 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. Photographic copy of original construction drawing, dated June 1911 (from paper-copy of aperture-card negative at Bureau of Reclamation, Pacific Northwest Regional Office, Boise, ID). CROSS SECTIONS. - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID

  12. 39. Photographic copy of original construction drawing, dated June 1911 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. Photographic copy of original construction drawing, dated June 1911 (from paper-copy of aperture-card negative at Bureau of Reclamation, Pacific Northwest Regional Office, Boise, ID). SECOND FLOOR PLAN. - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID

  13. 43. Photographic copy of original construction drawing, dated June 1911 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    43. Photographic copy of original construction drawing, dated June 1911 (from paper-copy of aperture-card negative at Bureau of Reclamation, Pacific Northwest Regional Office, Boise, ID). NORTH ELEVATION (NORTH SIDE) AND WEST ELEVATION (WEST SIDE). - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID

  14. 44. Photographic copy of original construction drawing, dated August 1911 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    44. Photographic copy of original construction drawing, dated August 1911 (from paper-copy of aperture-card negative at Bureau of Reclamation, Pacific Northwest Regional Office, Boise, ID). PLANS AND SECTIONS OF VAULTS. - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID

  15. 38. Photographic copy of original construction drawing, dated June 1911 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. Photographic copy of original construction drawing, dated June 1911 (from paper-copy of aperture-card negative at Bureau of Reclamation, Pacific Northwest Regional Office, Boise, ID). FIRST FLOOR PLAN. - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID

  16. Copying Machine Improvement

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Manufacturer of the Model 2210 copying machine was looking for a plastic valve bushing material that could be produced by a low-cost injection molding process to replace the unsuitable valve bushing they were using. NERAC conducted a computer search of the NASA database and was able to supply Nashua Corporation with several technical reports in their area of interest. Information aided the company's development of a urethane valve bushing which solved the problem and created a dramatic reduction in unit cost.

  17. The Solid Gold Copy Editor.

    ERIC Educational Resources Information Center

    Riblet, Carl, Jr.

    This book discusses the role of the newspaper copy editor on a daily newspaper and contains lessons instructing editors on how to prepare copy for print. The book is specifically designed to polish the skills of the already experienced newspaper copy editor, although a beginner will find the lessons useful and instructive. Contained in the lessons…

  18. Rare Copy Number Variants

    PubMed Central

    Grozeva, Detelina; Kirov, George; Ivanov, Dobril; Jones, Ian R.; Jones, Lisa; Green, Elaine K.; St Clair, David M.; Young, Allan H.; Ferrier, Nicol; Farmer, Anne E.; McGuffin, Peter; Holmans, Peter A.; Owen, Michael J.; O’Donovan, Michael C.; Craddock, Nick

    2015-01-01

    Context Recent studies suggest that copy number variation in the human genome is extensive and may play an important role in susceptibility to disease, including neuropsychiatric disorders such as schizophrenia and autism. The possible involvement of copy number variants (CNVs) in bipolar disorder has received little attention to date. Objectives To determine whether large (>100 000 base pairs) and rare (found in <1% of the population) CNVs are associated with susceptibility to bipolar disorder and to compare with findings in schizophrenia. Design A genome-wide survey of large, rare CNVs in a case-control sample using a high-density microarray. Setting The Wellcome Trust Case Control Consortium. Participants There were 1697 cases of bipolar disorder and 2806 nonpsychiatric controls. All participants were white UK residents. Main Outcome Measures Overall load of CNVs and presence of rare CNVs. Results The burden of CNVs in bipolar disorder was not increased compared with controls and was significantly less than in schizophrenia cases. The CNVs previously implicated in the etiology of schizophrenia were not more common in cases with bipolar disorder. Conclusions Schizophrenia and bipolar disorder differ with respect to CNV burden in general and association with specific CNVs in particular. Our data are consistent with the possibility that possession of large, rare deletions may modify the phenotype in those at risk of psychosis: those possessing such events are more likely to be diagnosed as having schizophrenia, and those without them are more likely to be diagnosed as having bipolar disorder. PMID:20368508

  19. 12. Photographic copy of copy of Twin Lakes Outlet Works ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photographic copy of copy of Twin Lakes Outlet Works construction drawing dated January 15, 1951. Drawn by W.A. Doe for the Twin Lakes Reservoir and Canal Co. (copy in possession of Bureau of Reclamation, location of original unknown) 'AS CONSTRUCTED' PLANS OF 1949-50, REHABILITATION OF TWIN LAKES RESERVOIR OUTLET WORKS, DETAILS OF DISCHARGE BASIN. - Twin Lakes Dam & Outlet Works, Beneath Twin Lakes Reservoir, T11S, R80W, S22, Twin Lakes, Lake County, CO

  20. 11. Photographic copy of copy of Twin Lakes Outlet Works ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photographic copy of copy of Twin Lakes Outlet Works construction drawing dated January 15, 1951. Drawn by W.A. Doe for the Twin Lakes Reservoir and Canal Co. (copy in possession of Bureau of Reclamation, location of original unknown) 'AS CONSTRUCTED' PLANS OF 1949-1950, REHABILITATION OF TWIN LAKES RESERVOIR OUTLET WORKS, DETAILS OF UPSTREAM WING WALLS. - Twin Lakes Dam & Outlet Works, Beneath Twin Lakes Reservoir, T11S, R80W, S22, Twin Lakes, Lake County, CO

  1. Does copy-resistance enhance cooperation in spatial prisoner's dilemma?

    NASA Astrophysics Data System (ADS)

    Shigaki, K.; Kokubo, S.; Tanimoto, J.; Hagishima, A.; Ikegaya, N.

    2012-05-01

    We propose a novel idea for the so-called pairwise-Fermi process by considering copy-resistance when an agent copies a neighbor's strategy, which implies that the focal agent with relatively affluent payoff vis-à-vis social average might be negative to copy her neighbor's strategy even if her payoff is less than the neighbor's payoff. Simulation results reveal that this idea with a revised strategy adaptation process significantly enhances cooperation for prisoner's dilemma games played on time-constant networks.

  2. 10. Photographic copy of copy of original construction drawing, dated ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Photographic copy of copy of original construction drawing, dated 1899?. Original in possession of Twin Lakes Reservoir and Canal Company, Ordway, Colorado. PLAN OF DAM AND HEAD GATES FOR THE TWIN LAKES RESERVOIR. - Twin Lakes Dam & Outlet Works, Beneath Twin Lakes Reservoir, T11S, R80W, S22, Twin Lakes, Lake County, CO

  3. Counting copy number and calories.

    PubMed

    White, Stefan

    2015-08-01

    Copy number variation (CNV) at several genomic loci has been associated with different human traits and diseases, but in many cases the findings could not be replicated. A new study provides insights into the degree of variation present at the amylase locus and calls into question a previous association between amylase copy number and body mass index. PMID:26220133

  4. 2. Credit GE. Photographic copy of photograph, refractory brick lining ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Credit GE. Photographic copy of photograph, refractory brick lining being laid in Test Stand 'A' flame pit to protect concrete from heat of rocket engine flames. (JPL negative no. 383-764, 8 March 1945) - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

  5. 9. Credit WCT. Photographic copy of photograph, interior view of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Credit WCT. Photographic copy of photograph, interior view of control room under construction in Control and Recording Center Building 4221/E-22. Stairway to tunnel system is in left background. (JPL negative no. 384-1927, 26 May 1959) - Jet Propulsion Laboratory Edwards Facility, Control & Recording Center, Edwards Air Force Base, Boron, Kern County, CA

  6. 1. Photograhic copy of construction drawing 17534 (from record group ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photograhic copy of construction drawing 175-34 (from record group of Civil Engineering, Hill Air Force Base, Utah). 8x10 negative and print. PRIMER LOADING PLANT SITE. - Ogden Arsenal, North of State Highway 193, East of State Highway 126 & Interstate 15, South of Davis-Weber Canal, Layton, Davis County, UT

  7. 5. Photographic copy of construction drawing 10989 (from record group ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Photographic copy of construction drawing 109-89 (from record group of Civil Engineering, Hill Air Force Base, Utah). Aug. 30, 1940. 8x10 negative and print. STANDARD SERVICE MAGAZINES & REST HOUSE DETONATOR, TETRYL, BLENDED TETRYL, MERCURY FULMONATE, BLACK POWDER, PLANS, ELEVATION SECTION & DETAILS. - Ogden Arsenal, Rest House, North side of North Carolina Lane, Layton, Davis County, UT

  8. 8. Photographic copy of cinstruction drawing 641 (from record group ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photographic copy of cinstruction drawing 641 (from record group of Civil Engineering, Hill Air Force Base, Utah). June 18, 1941. 8'x10' negative and print. Q.M. GAS & OIL HOUSE PIPING DETAILS. - Hill Field, Quatermaster Gas & Oil House, 7326 Wardleigh Road, Layton, Davis County, UT

  9. 7. Photographic copy of construction drawing 6912132 (from record group ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of construction drawing 6912132 (from record group of Civil Engineering, Hill Air Force Base, Utah). 1940. 8'x10' negative and print. HILL FIELD, UTAH, QM GAS & OIL HOUSE PLAN, ELEVATIONS, DETAIL & STRUCTURAL. - Hill Field, Quatermaster Gas & Oil House, 7326 Wardleigh Road, Layton, Davis County, UT

  10. 9. Photographic copy of aerial photograph of NUWC, 1993, view ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Photographic copy of aerial photograph of NUWC, 1993, view northwest. Original color negative no. 093(L)-09212.32 on file at photo lab at NUWC, Newport, R.I. Copyright-free. - Naval Undersea Warfare Center, East side of Smith & East Streets between Columbia & South Coves, New London, New London County, CT

  11. 7. Photographic copy of photograph (ca. 1933), original print and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of photograph (ca. 1933), original print and negative in possession of Selfridge Base Museum, Mt. Clemens, Michigan. NORTHWEST VIEW BAKING ROOM INTERIOR - Selfridge Field, Building No. 129, Wilbur Wright Boulevard at Ash Street, Mount Clemens, Macomb County, MI

  12. 7. Photographic copy of construction drawing 6912306 (from record group ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of construction drawing 6912-306 (from record group of Civil Enginering, Hill Air Force Base, Utah). May 21, 1940, 8'x10' negative and print. HILL FIELD UTAH A.C. OPERATIONS HANGAR AND ANNEXES, ELEVATIONS AND MISCELLANEOUS DETAILS. PART A - Hill Field, Aircraft Operations Hangar, 5970 Southgate Avenue, Layton, Davis County, UT

  13. 8. Photographic copy of construction drawing 6912306. (From record group ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photographic copy of construction drawing 6912-306. (From record group of Civil Enginering, Hill Air Force Base, Utah). May 21, 1940, 8'x10' negative and print. HILL FIELD UTAH A.C. OPERATIONS HANGAR AND ANNEXES, ELEVATIONS AND MISCELLANEOUS DETAILS. PART B - Hill Field, Aircraft Operations Hangar, 5970 Southgate Avenue, Layton, Davis County, UT

  14. 1. Credit GE. Photographic copy of photograph, test Stand 'A' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Credit GE. Photographic copy of photograph, test Stand 'A' reinforced concrete foundation under construction as seen from the southeast. Formwork is being removed as refractory brick lining is being laid in flame pit at the center. (JPL negative no. 383-763, 8 March 1945) - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

  15. 6. Credit WCT. Photographic copy of photograph, Advanced Solid Rocket ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Credit WCT. Photographic copy of photograph, Advanced Solid Rocket Motor (ASRM) test in progress at Test Stand 'E.' It was a JPL/Marshall Space Flight Center project. (JPL negative no. 344-4816 19 February 1982) - Jet Propulsion Laboratory Edwards Facility, Test Stand E, Edwards Air Force Base, Boron, Kern County, CA

  16. 7. Credit JPL. Photographic copy of photograph, view south on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Credit JPL. Photographic copy of photograph, view south on west side of Test Stand 'A' during excavation for new intra-stand tunnel system. Note equipment, tanks and piping installed in tower. (JPL negative no. 384-1540-D, 7 January 1957) - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

  17. 10. Credit WCT. Photographic copy of photograph, view looking south ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Credit WCT. Photographic copy of photograph, view looking south down axis of westernmost tunnel towards Test Stand 'A' from future site of Control and Recording Center Building 4221/E-22 (at junction of corrugated steel tunnel tubes). (JPL negative no. 384-1838-A, 9 March 1959) - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

  18. Credit WCT. Photographic copy of photograph, looking southwest across east ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, looking southwest across east side of Test Stand "D" while work is in progress to install conduit for new Dd horizontal test station. (JPL negative no. 384-2248-B, 3 May 1960) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  19. 3. Credit WCT. Photographic copy of photograph, test Stand 'B' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Credit WCT. Photographic copy of photograph, test Stand 'B' during setup for an engine test, looking northwest. (JPL negative no. 384-9432, 1 May 1972) - Jet Propulsion Laboratory Edwards Facility, Test Stand B, Edwards Air Force Base, Boron, Kern County, CA

  20. 2. Credit JPL. Photographic copy of photograph, looking northwest at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Credit JPL. Photographic copy of photograph, looking northwest at Test Stand 'B' set up to test a 20,000 pound thrust rocket engine. (JPL negative no. 384-1509-B, 22 October 1956) - Jet Propulsion Laboratory Edwards Facility, Test Stand B, Edwards Air Force Base, Boron, Kern County, CA

  1. Credit WCT. Photographic copy of photograph, oxidizer and fuel tank ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, oxidizer and fuel tank assembly for engine tests being raised by crane for permanent installation in Test Stand "D" tower. Each tank held 170 gallons of propellants. (JPL negative 384-2029-B, 7 August 1959) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  2. 5. Credit GE. Photographic copy of photograph, completed flame pit ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Credit GE. Photographic copy of photograph, completed flame pit in Test Stand 'A' with steel plate flame deflector over refractory brick. (JPL negative no. 383-1033, 17 January 1946) - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

  3. Credit WCT. Photographic copy of photograph, view looking southeast across ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view looking southeast across formwork for reinforced concrete base of Test Stand "D," with tunnel extension in foreground. (JPL negative no. 384-1838-D, 9 March 1959) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  4. 9. Photographic copy of photograph, Parachute Drying Room, ca. 1932, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Photographic copy of photograph, Parachute Drying Room, ca. 1932, in possession of Selfridge Base Museum (Historic Photograph File; location of original negative), Mt. Clemens, Michigan. NORTHEAST VIEW. DRYING ROOM WITH PARACHUTES - Selfridge Field, Building No. 121, Wilbur Wright Avenue west of Ash Street, Mount Clemens, Macomb County, MI

  5. 8. Photographic copy of photograph, Parachute Packing Room, ca. 1932, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photographic copy of photograph, Parachute Packing Room, ca. 1932, in possession of Selfridge Base Museum (Historic Photograph File; location of original negative), Mt. Clemens, Michigan. NORTHEAST VIEW, PACKING ROOM WITH PARACHUTES - Selfridge Field, Building No. 121, Wilbur Wright Avenue west of Ash Street, Mount Clemens, Macomb County, MI

  6. 7. Photographic copy of photograph, Parachute Building under construction, September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of photograph, Parachute Building under construction, September 10, 1931, in possession of Selfridge Base Museum. (Historic Photograph File; location of original negative), Mt. Clemens, Michigan. NORTHWEST VIEW, SOUTH AND EAST SIDES - Selfridge Field, Building No. 121, Wilbur Wright Avenue west of Ash Street, Mount Clemens, Macomb County, MI

  7. Credit WCT. Photographic copy of photograph, low level aerial view ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, low level aerial view of Test Stand "D," looking due west, after completion of Dd station installation in 1961. Note Test Stand "D" "neutralization pond" to immediate southeast of tower. (JPL negative no. 384-2997-B, 12 December 1961) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  8. Credit WCT. Photographic copy of photograph, view northwest at Test ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view northwest at Test Stand "D" tower with Dd station to right and "neutralization pond" in foreground. Note tunnel entrance way in left background. (JPL negative no. 384-3356-B, 20 November 1962) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  9. 8. Photographic copy of construction drawing 6912277 (from record group ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photographic copy of construction drawing 6912-277 (from record group of Civil Engineering, Hill Air Force Base, Utah). 1940. 8x10 negative and print. HILL FIELD, UTAH A.C. PAINT, OIL, & DOPE HOUSE TYPICAL DETAILS. - Hill Field, Aircraft Paint, Oil & Dope House, 5923 C Avenue, Layton, Davis County, UT

  10. 7. Photographic copy of construction drawing 6912279 (from record group ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of construction drawing 6912-279 (from record group of Civil Engineering, Hill Air Force Base, Utah). 1940. 8x10 negative and print. HILL FIELD, UTAH A.C. PAINT, OIL, & DOPE HOUSE ELEVATIONS AND DETAILS. - Hill Field, Aircraft Paint, Oil & Dope House, 5923 C Avenue, Layton, Davis County, UT

  11. 8. Photographic copy of color photograph of NUWC from the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photographic copy of color photograph of NUWC from the Thames River, 1988, view southeast. Original color negative no. N0211-SP-88(L)-02389.4 on file at photo lab at NUWC, Newport, R.I. Copyright-free. - Naval Undersea Warfare Center, East side of Smith & East Streets between Columbia & South Coves, New London, New London County, CT

  12. 7. Photographic copy of color photograph of NUWC from the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of color photograph of NUWC from the Thames River, 1988, view northwest. Original color negative no. N0211-SP-88(L)-02389.16 on file at photo lab at NUWC, Newport, R.I. Copyright-free. - Naval Undersea Warfare Center, East side of Smith & East Streets between Columbia & South Coves, New London, New London County, CT

  13. 3. Credit WCT. Photographic copy of photograph, interior view of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Credit WCT. Photographic copy of photograph, interior view of Steam Generator Plant 4280/E-81 when Clayton steam generators were being installed in 1972. (JPL negative no. 384-9600, 10 October 1972) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Steam Generator Plant, Edwards Air Force Base, Boron, Kern County, CA

  14. 4. Credit WCT. Photographic copy of photograph, test Stand 'B' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Credit WCT. Photographic copy of photograph, test Stand 'B' set up for shock tube and research on ship-to-ship fueling problems for the U.S. Coast Guard. (JPL negative no. 344-3743-A, October or November 1980) - Jet Propulsion Laboratory Edwards Facility, Test Stand B, Edwards Air Force Base, Boron, Kern County, CA

  15. 12. Photo of East End of Mansion COPIED FROM PHOTOGRAPHIC ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photo of East End of Mansion COPIED FROM PHOTOGRAPHIC PRINT IN COLLECTION OF MR. PHILIP DAWSON (Episcopal Seminary, Lynchburg, Va) ORIGINAL NEGATIVE BY THOMAS F. SCOTT -- IN EAA Plate No. 11 - General John Mason House, Analostan Island or Theodore Roosevelt Island, Washington, District of Columbia, DC

  16. Zero-Copy Objects System

    NASA Technical Reports Server (NTRS)

    Burleigh, Scott C.

    2011-01-01

    Zero-Copy Objects System software enables application data to be encapsulated in layers of communication protocol without being copied. Indirect referencing enables application source data, either in memory or in a file, to be encapsulated in place within an unlimited number of protocol headers and/or trailers. Zero-copy objects (ZCOs) are abstract data access representations designed to minimize I/O (input/output) in the encapsulation of application source data within one or more layers of communication protocol structure. They are constructed within the heap space of a Simple Data Recorder (SDR) data store to which all participating layers of the stack must have access. Each ZCO contains general information enabling access to the core source data object (an item of application data), together with (a) a linked list of zero or more specific extents that reference portions of this source data object, and (b) linked lists of protocol header and trailer capsules. The concatenation of the headers (in ascending stack sequence), the source data object extents, and the trailers (in descending stack sequence) constitute the transmitted data object constructed from the ZCO. This scheme enables a source data object to be encapsulated in a succession of protocol layers without ever having to be copied from a buffer at one layer of the protocol stack to an encapsulating buffer at a lower layer of the stack. For large source data objects, the savings in copy time and reduction in memory consumption may be considerable.

  17. 1 CFR 18.5 - Certified copies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Certified copies. 18.5 Section 18.5 General... DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.5 Certified copies. The certified copies or duplicate originals of each document must be submitted with the original. Each copy or...

  18. Chromatic adaptation in hard copy/soft copy comparisons

    NASA Astrophysics Data System (ADS)

    Fairchild, Mark D.

    1993-06-01

    The human visual system has evolved with a sophisticated set of mechanisms to produce stable perceptions of object colors across changes in illumination. This phenomenon is typically referred to as chromatic adaptation or color constancy. When viewing scenes or hard-copy reproductions, it is generally assumed that one adapts almost completely to the color and luminance of the prevailing light source. This is likely not the case when soft-copy image displays are viewed. Differences in the degree of chromatic adaptation to hard-copy and soft- copy displays point to two types of chromatic-adaptation mechanisms: sensory and cognitive. Sensory mechanisms are those that act automatically in response to the stimulus, such as retinal gain control. Cognitive mechanisms are those that rely on observers' knowledge of scene content. A series of experiments that measured the spatial, temporal, and chromatic properties of chromatic-adaptation mechanisms are reviewed and a mathematical model for predicting these chromatic adaptation effects is briefly described along with some practical recommendations, based on psychophysical experiments, on how to approach these problems in typical cross-media color reproduction situations.

  19. Copy number variation and mutation

    NASA Astrophysics Data System (ADS)

    Clark, Brian; Weidner, Jacob; Wabick, Kevin

    2009-11-01

    Until very recently, the standard model of DNA included two genes for each trait. This dated model has given way to a model that includes copies of some genes well in excess of the canonical two. Copy number variations in the human genome play critical roles in causing or aggravating a number of syndromes and diseases while providing increased resistance to others. We explore the role of mutation, crossover, inversion, and reproduction in determining copy number variations in a numerical simulation of a population. The numerical model consists of a population of individuals, where each individual is represented by a single strand of DNA with the same number of genes. Each gene is initially assigned to one of two traits. Fitness of the individual is determined by the two most fit genes for trait one, and trait two genetic material is treated as a reservoir of junk DNA. After a sufficient number of generations, during which the genetic distribution is allowed to reach a steady-state, the mean numberof genes per trait and the copy number variation are recorded. Here, we focus on the role of mutation and compare simulation results to theory.

  20. Rawcopy: Improved copy number analysis with Affymetrix arrays

    PubMed Central

    Mayrhofer, Markus; Viklund, Björn; Isaksson, Anders

    2016-01-01

    Microarray data is subject to noise and systematic variation that negatively affects the resolution of copy number analysis. We describe Rawcopy, an R package for processing of Affymetrix CytoScan HD, CytoScan 750k and SNP 6.0 microarray raw intensities (CEL files). Noise characteristics of a large number of reference samples are used to estimate log ratio and B-allele frequency for total and allele-specific copy number analysis. Rawcopy achieves better signal-to-noise ratio and higher proportion of validated alterations than commonly used free and proprietary alternatives. In addition, Rawcopy visualizes each microarray sample for assessment of technical quality, patient identity and genome-wide absolute copy number states. Software and instructions are available at http://rawcopy.org. PMID:27796336

  1. Copy number variation and schizophrenia.

    PubMed

    St Clair, David

    2009-01-01

    Over the last 12 months, a series of major articles have reported associations with schizophrenia of copy number variants at 1q21, 15q11.2, 15q13.3, 16p11.2, 22q12, and Neurexin 1 loci. These are rare high-penetrant mutations that increase risk not only of schizophrenia but also of a range of other psychiatric disorders including autism and mental retardation. In some cases, the same phenotype can occur irrespective of whether the copy number variant causes a deletion or duplication. Some of these mutations occur at very high rates in human populations, but because of reduced fecundity associated with major psychiatric disorders the overall frequency in the population remains low. These new findings raise fundamental clinical and scientific questions concerning classification of major neuropsychiatric disorders, modes of inheritance, diagnostics, and genetic counseling. Although the loci identified so far account for only a small proportion of cases, many more are likely to be discovered over the next few years. A major focus of research will be to identify the key, the genetic and environmental determinants of schizophrenia risk in carriers of these copy number variants, and to discover whether their rates of mutation are unstable or fixed. PMID:18990708

  2. 48 CFR 1501.105-3 - Copies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Purpose, Authority, Issuance 1501.105-3 Copies. Copies of the EPAAR in Federal Register and CFR form may be purchased from the Superintendent of Documents, Government Printing Office (GPO), Washington,...

  3. 48 CFR 1501.105-3 - Copies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Purpose, Authority, Issuance 1501.105-3 Copies. Copies of the EPAAR in Federal Register and CFR form may be purchased from the Superintendent of Documents, Government Printing Office (GPO), Washington,...

  4. 48 CFR 1501.105-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Copies. 1501.105-3 Section 1501.105-3 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL GENERAL Purpose, Authority, Issuance 1501.105-3 Copies. Copies of the EPAAR in Federal Register and CFR form...

  5. 48 CFR 1401.105-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Copies. 1401.105-3 Section 1401.105-3 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL DEPARTMENT OF THE INTERIOR ACQUISITION REGULATION SYSTEM Purpose, Authority, Issuance 1401.105-3 Copies. Copies of...

  6. 14 CFR 1206.207 - Copies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Copies. 1206.207 Section 1206.207 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.207 Copies. The furnishing of a single copy of the...

  7. 14 CFR 1206.207 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Copies. 1206.207 Section 1206.207 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.207 Copies. The furnishing of a single copy of the...

  8. Patterns, Correlates, and Reduction of Homework Copying

    ERIC Educational Resources Information Center

    Palazzo, David J.; Lee, Young-Jin; Warnakulasooriya, Rasil; Pritchard, David E.

    2010-01-01

    Submissions to an online homework tutor were analyzed to determine whether they were copied. The fraction of copied submissions increased rapidly over the semester, as each weekly deadline approached and for problems later in each assignment. The majority of students, who copied less than 10% of their problems, worked steadily over the three days…

  9. 36 CFR 703.20 - File copies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false File copies. 703.20 Section... Is Not a Party § 703.20 File copies. The Office of the General Counsel will maintain the official file of copies of all demands served on the Library and deciding officials' responses....

  10. 14 CFR § 1206.207 - Copies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Copies. § 1206.207 Section § 1206.207 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.207 Copies. The furnishing of a single copy of the...

  11. 14 CFR 1206.207 - Copies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Copies. 1206.207 Section 1206.207 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.207 Copies. The furnishing of a single copy of the...

  12. 14 CFR 1206.207 - Copies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Copies. 1206.207 Section 1206.207 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.207 Copies. The furnishing of a single copy of the...

  13. 49 CFR 7.8 - Copies

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Copies 7.8 Section 7.8 Transportation Office of the Secretary of Transportation PUBLIC AVAILABILITY OF INFORMATION Information Required To Be Made Public by DOT § 7.8 Copies Copies of any material covered by this subpart that is not published...

  14. 48 CFR 1.105-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 1.105-3 Copies. Copies of the FAR in Federal Register, loose-leaf, CD-ROM and CFR form may be purchased from the Superintendent of Documents, Government... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Copies. 1.105-3 Section...

  15. 48 CFR 3401.104-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... GENERAL ED ACQUISITION REGULATION SYSTEM Purpose, Authority, Issuance 3401.104-3 Copies. Copies of the EDAR in the Federal Register and Code of Federal Regulations (CFR) form may be purchased from the... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Copies. 3401.104-3...

  16. 48 CFR 1001.105-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... TREASURY ACQUISITION REGULATORY (DTAR) SYSTEM Purpose, Authority, Issuance 1001.105-3 Copies. Copies of the DTAR in Federal Register or CFR form may be purchased from the Superintendent of Documents, Government... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Copies. 1001.105-3...

  17. 48 CFR 2001.104-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... REGULATORY COMMISSION ACQUISITION REGULATION SYSTEM Purpose, Authority, Issuance 2001.104-3 Copies. Copies of the NRCAR in Federal Register and CFR form may be purchased from the Superintendent of Documents... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Copies. 2001.104-3...

  18. 48 CFR 901.104-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Copies. 901.104-3 Section 901.104-3 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 901.104-3 Copies. Copies of the DEAR published in the...

  19. 44 CFR 6.81 - Additional copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Additional copies. 6.81... HOMELAND SECURITY GENERAL IMPLEMENTATION OF THE PRIVACY ACT OF 1974 Fees § 6.81 Additional copies. A reasonable number of additional copies shall be provided for the applicable fee to a requestor who...

  20. 22 CFR 92.76 - Copying documents.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Copying documents. 92.76 Section 92.76 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES NOTARIAL AND RELATED SERVICES Copying, Recording, Translating and Procuring Documents § 92.76 Copying documents. (a) Consular authority. The consular officer...

  1. 22 CFR 92.76 - Copying documents.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Copying documents. 92.76 Section 92.76 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES NOTARIAL AND RELATED SERVICES Copying, Recording, Translating and Procuring Documents § 92.76 Copying documents. (a) Consular authority. The consular officer...

  2. 22 CFR 92.76 - Copying documents.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Copying documents. 92.76 Section 92.76 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES NOTARIAL AND RELATED SERVICES Copying, Recording, Translating and Procuring Documents § 92.76 Copying documents. (a) Consular authority. The consular officer...

  3. 22 CFR 92.76 - Copying documents.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Copying documents. 92.76 Section 92.76 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES NOTARIAL AND RELATED SERVICES Copying, Recording, Translating and Procuring Documents § 92.76 Copying documents. (a) Consular authority. The consular officer...

  4. 22 CFR 92.76 - Copying documents.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Copying documents. 92.76 Section 92.76 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES NOTARIAL AND RELATED SERVICES Copying, Recording, Translating and Procuring Documents § 92.76 Copying documents. (a) Consular authority. The consular officer...

  5. 14 CFR 187.7 - Copies; seal.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... H of 49 CFR part 7. ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Copies; seal. 187.7 Section 187.7... REGULATIONS FEES § 187.7 Copies; seal. The fees for furnishing photostatic or similar copies of documents...

  6. 14 CFR 187.7 - Copies; seal.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... H of 49 CFR part 7. ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Copies; seal. 187.7 Section 187.7... REGULATIONS FEES § 187.7 Copies; seal. The fees for furnishing photostatic or similar copies of documents...

  7. 14 CFR 187.7 - Copies; seal.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... H of 49 CFR part 7. ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Copies; seal. 187.7 Section 187.7... REGULATIONS FEES § 187.7 Copies; seal. The fees for furnishing photostatic or similar copies of documents...

  8. 14 CFR 187.7 - Copies; seal.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... H of 49 CFR part 7. ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Copies; seal. 187.7 Section 187.7... REGULATIONS FEES § 187.7 Copies; seal. The fees for furnishing photostatic or similar copies of documents...

  9. 14 CFR 187.7 - Copies; seal.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... H of 49 CFR part 7. ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Copies; seal. 187.7 Section 187.7... REGULATIONS FEES § 187.7 Copies; seal. The fees for furnishing photostatic or similar copies of documents...

  10. Credit WCT. Photographic copy of photograph, view looking north at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view looking north at Test Stand "D" engine exhaust gas deflector or "flame bucket" just after its installation. This device was water-cooled. It also injected sprays of water into the gas flow to cool the exhaust down. (JPL negative no. 384-1861-A, 8 April 1959) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  11. 2. Credit WCT. Photographic copy of photograph, view looking northnortheast ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Credit WCT. Photographic copy of photograph, view looking north-northeast across formwork for Control and Recording Center Building 4221/E-22. Formwork is for access to tunnel system. In distance work on Test Stand 'D' is proceeding. (JPL negative no. 384-1839-B, 17 March 1959) - Jet Propulsion Laboratory Edwards Facility, Control & Recording Center, Edwards Air Force Base, Boron, Kern County, CA

  12. Credit WCT. Photographic copy of photograph, view looking northwest at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view looking northwest at complete Test Stand "D" installation as of January 1962. Note closed-circuit television camera at extreme left, along with MMH (fuel) storage tank. Hatch of Dd test cell is open; nearby stand MMH run tanks for Dd station. (JPL negative no. 384-2591-A, 25 January 1961) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  13. Photographic copy of photograph, aerial view looking north at Jet ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph, aerial view looking north at Jet Propulsion Laboratory, Edwards Test Station complex in 1959, shortly after completion of 'D' stand construction and installation of underground tunnel system. Test stands 'A,' 'B,' 'C,' and 'D' are in view; the Control and Recording Center (Building 4221/E-22) is still under construction. (JPL negative no. 384-1917-A, 28 May 1959) - Jet Propulsion Laboratory Edwards Facility, Edwards Air Force Base, Boron, Kern County, CA

  14. Photographic copy of photograph, aerial view looking south at Jet ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph, aerial view looking south at Jet Propulsion Laboratory, Edwards Test Station complex in 1959, shortly after completion of Test Stand 'D' construction and installation of underground tunnel system. Test Stand 'D' is in the foreground, Test Stand 'A' complex in the background. Roads are as yet unpaved. (JPL negative no. 384-1917-B, 28 May 1959) - Jet Propulsion Laboratory Edwards Facility, Edwards Air Force Base, Boron, Kern County, CA

  15. 4. Credit GE. Photographic copy of photograph, looking northeast into ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Credit GE. Photographic copy of photograph, looking northeast into 'A' stand flame trench as seen from the southeast corner of 'A' stand foundation. The concrete construction at the bottom of the trench is a water pond with sump for cooling rocket engine plumes before they blow into the desert to the east. (JPL negative no. 383-940-B, 29 August 1945) - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

  16. Credit WCT. Photographic copy of photograph, view looking east at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view looking east at Test Stand "D" during erection of the test stand tower. Note wire lath nailed over gypsum board on Building 4222/E-23 at far left in preparation for stucco covering (temporary construction). Stucco would not require painting in desert. (JPL negative no. 384-1865-A, 13 April 1959) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  17. Credit WCT. Photographic copy of photograph, view north across "neutralization ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view north across "neutralization pond" at Test Stand "D," showing complete Dd station with new Y-Stage and Z-Stage steam-driven ejectors, and "Hyprox" steam generator which powered ejectors. (JPL negative no. 384-3356-B, 20 November 1962) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  18. Credit WCT. Photographic copy of photograph, view east southeast across ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view east southeast across Dd station ejectors showing detail of "Hyprox" steam generator. Note that steam generator is placed above Z-stage ejector; an insulated pipe running between the Dd train rails supplies steam to the Y-Stage ejector. Note emergency eyewash stand at extreme right of view. (JPL negative no. 384-3376, 3 December 1962) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  19. Credit WCT. Photographic copy of photograph, view east showing the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view east showing the Y-stage ejector nozzle as the Y-stage ejector is being installed in the Dd ejector train in 1962. In the distance can be seen the western end of the Z-stage ejector. (JPL negative no. 384-3345-A, 8 November 1962) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  20. 6. Credit GE. Photographic copy of photograph, view looking east ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Credit GE. Photographic copy of photograph, view looking east at Test Stand 'A' during test firing of a liquid-fueled Corporal engine. Structure in immediate left foreground of view appears to be a propellant tank enclosure (JPL negative no. 383-1225, July 1945); compare HAER CA-163-A-7 for enclosure. - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

  1. Copying and Evolution of Neuronal Topology

    PubMed Central

    Fernando, Chrisantha; Karishma, K. K.; Szathmáry, Eörs

    2008-01-01

    We propose a mechanism for copying of neuronal networks that is of considerable interest for neuroscience for it suggests a neuronal basis for causal inference, function copying, and natural selection within the human brain. To date, no model of neuronal topology copying exists. We present three increasingly sophisticated mechanisms to demonstrate how topographic map formation coupled with Spike-Time Dependent Plasticity (STDP) can copy neuronal topology motifs. Fidelity is improved by error correction and activity-reverberation limitation. The high-fidelity topology-copying operator is used to evolve neuronal topologies. Possible roles for neuronal natural selection are discussed. PMID:19020662

  2. [Dual copy-supplement collimator].

    PubMed

    Wang, Z K; Lian, X; Wang, Y

    2001-01-01

    Dual Copy-Supplement Collimator consists of two lead conic sections centered on one common radioactive source and having a lot of small square holes on them. When scanning electron beams strike X-Ray target and create some X-Ray fields while passing through the primary section, they penetrate the secondary section and generate even smaller field units(FU). Using these FUs would compose various treatment fields with different energy (dosage). It is able not only to replace many existing collimators such as MLC, but also to make the conformal radiotherapy easier.

  3. Aggregate Remote Memory Copy Interface

    2006-02-23

    The purpose of the Aggregate Remote Memory Copy (ARMCI) library is to provide a general- purpose, efficient, and Widely portable remote memory access (RMA) operations (one-sided communication) optimized for Contiguous and noncontiguous (strided, scatter/gather, I/O vector) data transfers. In addition, ARMCI includes a set of atomic and mutual exclusion operations. The development ARMCI is driven by the need to support the global-addres space communication model in context of distributed regular or irregular distributed data structures,more » communication libraries, and compilers. ARMCI is a standalone system that could be used to support user-level libraries and applications that use MPI or PVM.« less

  4. 48 CFR 401.105-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATION SYSTEM Purpose, Authority, Issuance 401.105-3 Copies. Copies of the AGAR published in CFR form may be purchased from the Superintendent of Documents, Government Printing Office, Washington, D.C. 20402. Requests should reference Chapter 4 of Title 48 CFR....

  5. 48 CFR 401.105-3 - Copies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ACQUISITION REGULATION SYSTEM Purpose, Authority, Issuance 401.105-3 Copies. Copies of the AGAR published in CFR form may be purchased from the Superintendent of Documents, Government Printing Office, Washington, D.C. 20402. Requests should reference Chapter 4 of Title 48 CFR....

  6. Copy-Editing: The Cambridge Handbook.

    ERIC Educational Resources Information Center

    Butcher, Judith

    This handbook is designed as a reference manual for copy editors who prepare typescript for printing. It deals with the following topics: the copy editor's function; the work to be done at each stage in the production process; some difficult points of spelling, capitalization, and other features collectively known as "house style"; the parts of a…

  7. 14 CFR 249.4 - Photographic copies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Photographic copies. 249.4 Section 249.4 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PRESERVATION OF AIR CARRIER RECORDS General Instructions § 249.4 Photographic copies. (a)...

  8. 22 CFR 401.13 - Copies required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Copies required. 401.13 Section 401.13 Foreign Relations INTERNATIONAL JOINT COMMISSION, UNITED STATES AND CANADA RULES OF PROCEDURE Applications § 401.13 Copies required. (a) Subject to paragraph (c) of this section, two duplicate originals and fifty...

  9. 48 CFR 601.105-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Copies. 601.105-3 Section 601.105-3 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL DEPARTMENT OF STATE ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 601.105-3 Copies. The DOSAR is available...

  10. 48 CFR 201.105-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Copies. 201.105-3 Section 201.105-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 201.105-3 Copies....

  11. 48 CFR 3001.105-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Copies. 3001.105-3 Section 3001.105-3 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY....105-3 Copies. The HSAR is available in the Federal Register and electronically at...

  12. 48 CFR 501.105-3 - Copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICES ADMINISTRATION ACQUISITION REGULATION SYSTEM Purpose, Authority, Issuance 501.105-3 Copies. The GSAR in CFR form may be purchased from: Superintendent of Documents, Government Printing Office... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Copies. 501.105-3...

  13. Structure and mechanism of COPI vesicle biogenesis.

    PubMed

    Jackson, Lauren P

    2014-08-01

    Distinct trafficking pathways within the secretory and endocytic systems ensure prompt and precise delivery of specific cargo molecules to different cellular compartments via small vesicular (50-150nm) and tubular carriers. The COPI vesicular coat is required for retrograde trafficking from the cis-Golgi back to the ER and within the Golgi stack. Recent structural data have been obtained from X-ray crystallographic studies on COPI coat components alone and on COPI subunits in complex with either cargo motifs or Arf1, and from reconstructions of COPI coated vesicles by electron tomography. These studies provide important molecular information and indicate key differences in COPI coat assembly as compared with clathrin-based and COPII-based coats. PMID:24840894

  14. 25 CFR 571.13 - Copies of audit reports.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... submit to the Commission two paper copies or one electronic copy of the financial statements and audits... Commission two paper copies or one electronic copy of the financial statements, reports, and audits required... 25 Indians 2 2010-04-01 2010-04-01 false Copies of audit reports. 571.13 Section 571.13...

  15. Credit WCT. Photographic copy of photograph, interior view of Dd ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, interior view of Dd test cell with VO (Viking Orbiter)-75 spacecraft engine mounted for testing. (Viking was a Mars orbiter and lander mission.) The end of the engine nozzle is inserted into a diffuser in order to conduct exhaust gases out of the chamber. All piping and tubing is stainless steel. Note ports in background through which instrumentation wiring passes. Nozzles at top of view are part of an internal fire suppression (or "Firex") system. (JPL negative no. 384-9428, 24 April 1972) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  16. 3. Credit GE. Photographic copy of photograph, east elevation of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Credit GE. Photographic copy of photograph, east elevation of 'A' stand on 29 August 1945. A steel frame has been erected for a travelling hoist, and propellant lines are visible to the right (north) of the stand, rising from storage tanks installed in the north side of the stand. To the east of the flame pit is a concrete water pond and sump designed to cool rocket engine exhaust. Exhaust was directed east in the direction of prevailing winds. (JPL negative no. 383-940-A, 29 August 1945) - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

  17. 3. Credit JPL. Photographic copy of photograph, view south into ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Credit JPL. Photographic copy of photograph, view south into oxidizer tank enclosure and controls on the north side of Test Stand 'C' shortly after the stand's construction in 1957 (oxidizer contents not determined). To the extreme left appear fittings for mounting an engine for tests. Note the robust stainless steel flanges and fittings necessary to contain highly pressurized corrosive chemicals. (JPL negative no. 384-1608-C, 29 August 1957) - Jet Propulsion Laboratory Edwards Facility, Test Stand C, Edwards Air Force Base, Boron, Kern County, CA

  18. Credit WCT. Photographic copy of photograph, view of Test Stand ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view of Test Stand "D" from Test Stand "A" while a rocket engine test is in progress. Cloud of steam is from partly from water created by propellant reaction and from water sprayed by flame bucket into engine exhaust for cooling purposes. A portion of Test Stand "C" is visible at the far right. (JPL negative no. 384-2082-B, 23 October 1959) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  19. 2. Credit JPL. Photographic copy of photograph, looking northeast at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Credit JPL. Photographic copy of photograph, looking northeast at unfinished original Test Stand 'C' construction. A portion of the corrugated steel tunnel tube connecting Test Stand 'C' to the first phase of JPL tunnel system construction is visible in the foreground. The steel frame used to support propellant tanks and engine equipment has been erected. The open trap door leads to a chamber inside the Test Stand 'C' base where gaseous nitrogen is distributed via manifolds to Test Stand 'C' control valves. (JPL negative no. 384-1568-A, 19 March 1957) - Jet Propulsion Laboratory Edwards Facility, Test Stand C, Edwards Air Force Base, Boron, Kern County, CA

  20. Credit WCT. Photographic copy of photograph, view looking south down ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view looking south down easternmost tunnel axis during second phase of JPL tunnel construction in 1959. Reinforced concrete formwork for Test Stand "D" foundation appears in left foreground. Formwork for Building 4222/E-23 (Test Stand "D" Workshop) is in place in right foreground with disturbed earth for western leg of tunnel system evident in background. Test Stand "C" is in center background, where first phase of tunnel construction ended. Test Stand "A" appears as tower in right background. (JPL negative no. 384-1838-C, 9 March 1959) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  1. Photographic copy of photograph, aerial view looking north and showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph, aerial view looking north and showing Test Stand 'A' (at bottom), Test Stand 'B' (upper right), and a portion of Test Stand 'C' (top of view). Compare HAER CA-163-1 and 2 and note addition of liquid nitrogen storage tank (Building 4262/E-63) to west of Test Stand 'C' as well as various ancillary facilities located behind earth barriers near Test Stand 'C.' (JPL negative no. 384-3006-A, 12 December 1961) - Jet Propulsion Laboratory Edwards Facility, Edwards Air Force Base, Boron, Kern County, CA

  2. Credit WCT. Photographic copy of photograph, in 1963 a "Y" ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, in 1963 a "Y" branch connector was introduced at the Dd test station in order to add a second test cell (named Dy) to the Dd train of coolers and ejectors. This view shows the diffuser used to connect the Dy test chamber with the "Y" branch. This Dy chamber was the second one installed at this station; it was later moved and incorporated into a larger horizontal test station retaining the Dy designation. (JPL negative no. 384-11176-B, 17 May 1976) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  3. 8. Credit JPL. Photographic copy of photograph, view west down ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Credit JPL. Photographic copy of photograph, view west down from Test Stand 'A' tower across newly installed tunnel tube to corner of Building 4201/E-2, Test Stand 'A' Workshop (demolished in 1985). Note the wooden retaining structure erected in the foreground to retain earth once the tunnel trench is backfilled (this retaining wall remained in 1994). Note also the propellant control piping on the Test Stand 'A' platform in the immediate foreground. (JPL negative no. 384-1547-C, 6 February 1957) - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

  4. Credit WCT. Photographic copy of photograph, view of Test Stand ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view of Test Stand "D" from the south with tower ejector system in operation during a 1972 engine test. Note steam evolving from Z-stage ejectors atop the interstage condenser in the tower. Note also the "Hyprox" steam generator straddling the Dd ejector train to the right. The new Dy horizontal train has not been erected as of this date. In the distance is Test Stand "E." (JPL negative no. 384-9766-AC, 28 November 1972) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  5. Photographic copy of photograph, aerial view looking down at Jet ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph, aerial view looking down at Jet Propulsion Laboratory, Edwards Test Station complex in 1961, with north toward the top of the view. Dd test station has been added to Test Stand 'D,' liquid nitrogen storage facility E-63 has been built, as well as several adjuncts to Test Stand 'C' behind earth barriers, such as oxidizer facility at 4263/E-64 and hydrogen tank at 4264/E-65. (JPL negative no. 384-3003-A, 12 December 1961) - Jet Propulsion Laboratory Edwards Facility, Edwards Air Force Base, Boron, Kern County, CA

  6. Kinetic versus Energetic Discrimination in Biological Copying

    NASA Astrophysics Data System (ADS)

    Sartori, Pablo; Pigolotti, Simone

    2013-05-01

    We study stochastic copying schemes in which discrimination between a right and a wrong match is achieved via different kinetic barriers or different binding energies of the two matches. We demonstrate that, in single-step reactions, the two discrimination mechanisms are strictly alternative and cannot be mixed to further reduce the error fraction. Close to the lowest error limit, kinetic discrimination results in a diverging copying velocity and dissipation per copied bit. On the other hand, energetic discrimination reaches its lowest error limit in an adiabatic regime where dissipation and velocity vanish. By analyzing experimentally measured kinetic rates of two DNA polymerases, T7 and Polγ, we argue that one of them operates in the kinetic and the other in the energetic regime. Finally, we show how the two mechanisms can be combined in copying schemes implementing error correction through a proofreading pathway.

  7. NASA printing, duplicating, and copying management handbook

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This handbook provides information and procedures for the implementation of NASA policy and applicable laws and regulations relating to printing, duplicating, and copying. The topics addressed include a description of relevant laws and regulations, authorizations required, and responsible entities for NASA printing, duplicating, and copying. The policy of NASA is to ensure understanding and application of authority and responsibility on printing matters. Where necessary, the handbook clarifies the intent of basic laws and regulations applicable to NASA.

  8. COPI Is Required for Enterovirus 71 Replication

    PubMed Central

    Wang, Jianmin; Wu, Zhiqiang; Jin, Qi

    2012-01-01

    Enterovirus 71 (EV71), a member of the Picornaviridae family, is found in Asian countries where it causes a wide range of human diseases. No effective therapy is available for the treatment of these infections. Picornaviruses undergo RNA replication in association with membranes of infected cells. COPI and COPII have been shown to be involved in the formation of picornavirus-induced vesicles. Replication of several picornaviruses, including poliovirus and Echovirus 11 (EV11), is dependent on COPI or COPII. Here, we report that COPI, but not COPII, is required for EV71 replication. Replication of EV71 was inhibited by brefeldin A and golgicide A, inhibitors of COPI activity. Furthermore, we found EV71 2C protein interacted with COPI subunits by co-immunoprecipitation and GST pull-down assay, indicating that COPI coatomer might be directed to the viral replication complex through viral 2C protein. Additionally, because the pathway is conserved among different species of enteroviruses, it may represent a novel target for antiviral therapies. PMID:22662263

  9. EGFR gene copy number increase in vulvar carcinomas is linked with poor clinical outcome.

    PubMed

    Woelber, L; Hess, S; Bohlken, H; Tennstedt, P; Eulenburg, C; Simon, R; Gieseking, F; Jaenicke, F; Mahner, S; Choschzick, M

    2012-02-01

    EGFR copy number increases have been frequently reported in cancer including vulvar carcinomas. Co-amplification of cancer genes plays an important role in the development of many tumour types. To better understand the effect of EGFR aberrations on vulvar cancer phenotype and patient prognosis, the authors analysed EGFR copy number changes using fluorescence in situ hybridisation and EGFR expression by immunohistochemistry in a tissue microarray containing 183 squamous cell carcinomas of vulva. Furthermore, the authors analysed the co-amplification frequency of EGFR with HER2, CCND1, MYC and PIK3CA, respectively. EGFR copy number increase was found in 39.3% of the tumours. Seventeen per cent of vulvar carcinomas showed EGFR high polysomy including 9% with amplification of the EGFR gene. Copy number gain of the EGFR locus was associated with non-basaloid phenotype (p=0.03), high-tumour stage (p<0.001), human papillomaviruse negativity of tumours (p=0.04) and the number of lymph node metastases (p=0.02). EGFR protein expression was statistically correlated to EGFR copy number increase (p<0.05). The observed co-amplification rate of EGFR with all four additionally examined oncogenes was much higher than statistically expected. There was a highly significant association between EGFR copy number increase and CCND1 amplifications (p<0.001) as well as the total number of gene amplifications (p=0.04). EGFR copy number gains were significantly related to unfavourable patient outcome in univariate analysis and multivariate Cox regression analysis. In conclusion, EGFR copy number increases are detectable in a substantial proportion of vulvar carcinomas with relationships to advanced tumour stages and the development of lymph node metastases. EGFR copy number aberrations are connected to other gene amplifications and probably define an human papillomaviruses-independent pathway in the development of vulvar carcinomas. These data support the potential utility of EGFR inhibitors

  10. P1 plasmid replication. Role of initiator titration in copy number control.

    PubMed

    Pal, S K; Mason, R J; Chattoraj, D K

    1986-11-20

    The copy number control locus incA of unit copy plasmid P1 maps in a region containing nine 19 base-pair repeats. Previous results from studies in vivo and in vitro indicated that incA interacts with the plasmid-encoded RepA protein, which is essential for replication. It has been proposed that the repeat sequences negatively control copy number by sequestering the RepA protein, which is rate-limiting for replication. Our results lend further support to this hypothesis. Here we show that the repeats can be deleted completely from P1 miniplasmids and the deletion results in an approximately eightfold increase in plasmid copy number. So, incA sequences are totally dispensable for replication and have only a regulatory role. The copy number of incA-deleted plasmids can be reduced if incA sequences are present in trans or are reincorporated at two different positions in the plasmid. This reduction in copy number is not due to lowered expression of the repA gene in the presence of incA. We show that one repeat sequence is sufficient to bind RepA and can reduce the copy number of incA-deleted plasmids. When part of the repeat was deleted, it lost its ability to bind as well as influence copy number. These results show a strong correlation between the capacity of incA repeats to bind RepA protein both in vivo and in vitro, and the function of incA in the control of copy number.

  11. Low AMY1 Gene Copy Number Is Associated with Increased Body Mass Index in Prepubertal Boys

    PubMed Central

    Verginelli, Fabio; De Lellis, Laura; Capelli, Cristian; Verzilli, Delfina; Chiarelli, Francesco; Mohn, Angelika; Cama, Alessandro

    2016-01-01

    Background Genome-wide association studies have identified more than 60 single nucleotide polymorphisms associated with Body Mass Index (BMI). Additional genetic variants, such as copy number variations (CNV), have also been investigated in relation to BMI. Recently, the highly polymorphic CNV in the salivary amylase (AMY1) gene, encoding an enzyme implicated in the first step of starch digestion, has been associated with obesity in adults and children. We assessed the potential association between AMY1 copy number and a wide range of BMI in a population of Italian school-children. Methods 744 children (354 boys, 390 girls, mean age (±SD): 8.4±1.4years) underwent anthropometric assessments (height, weight) and collection of saliva samples for DNA extraction. AMY1 copies were evaluated by quantitative PCR. Results A significant increase of BMI z-score by decreasing AMY1 copy number was observed in boys (β: -0.117, p = 0.033), but not in girls. Similarly, waist circumference (β: -0.155, p = 0.003, adjusted for age) was negatively influenced by AMY1 copy number in boys. Boys with 8 or more AMY1 copy numbers presented a significant lower BMI z-score (p = 0.04) and waist circumference (p = 0.01) when compared to boys with less than 8 copy numbers. Conclusions In this pediatric-only, population-based study, a lower AMY1 copy number emerged to be associated with increased BMI in boys. These data confirm previous findings from adult studies and support a potential role of a higher copy number of the salivary AMY1 gene in protecting from excess weight gain. PMID:27149670

  12. Negative necrotaxis.

    PubMed

    Ragot, R

    1993-01-01

    We studied necrotaxis in several strains of protists and compared the reaction of living cells in the vicinity of cells killed by a ruby laser. Negative necrotaxis was observed for the unicellular green alga Euglena gracilis, whereas Chlamydomonas was shown to exhibit positive necrotaxis. The cellular colony Pandorina morum exhibited no reaction to the killing of nearby colonies. Both the colorless cryptomonad Chilomonas paramecium and the ciliate Tetrahymena pyriformis exhibited negative necrotaxis following the lysis of vitally stained specimens of their own species. They also exhibited negative necrotaxis following the lysis of Euglena cells. It was also demonstrated that the cellular content of Euglena cells lysed by heat or by a mechanical procedure acts as a repellent to intact Euglena cells. These results suggest that the negative necrotaxis provoked in Euglena by the laser irradiation is probably due to the chemotactic effect produced by the release of cell content in the extracellular medium. This cell content could, according to its chemical composition, act either as a repellent, an attractant, or be inactive. The sensitivity of cells (specific or nonspecific ion channels or chemoreceptors) are also of prime importance in the process.

  13. Mitochondrial DNA Copy Number in Spermatozoa of Fertile Stallions.

    PubMed

    Orsztynowicz, M; Pawlak, P; Podstawski, Z; Nizanski, W; Partyka, A; Gotowiecka, M; Kosiniak-Kamysz, K; Lechniak, D

    2016-06-01

    Predicting male fertility on non-invasive sperm traits is of big importance to human and animal reproduction strategies. Combining the wide range of parameters monitored by computer-assisted sperm analysis (CASA) with some molecular traits (e.g. mtDNA content) may help to identify markers of the male fertility. The aim of this study was to characterize variation in the mtDNA copy number in equine sperm and to investigate whether mtDNA content is correlated with quality traits of stallion spermatozoa and the age of the male. Ejaculates collected from 53 fertile stallions were divided into four age groups (3-5, 6-10, 11-14 and >15 years) and were subjected to a complex investigation including conventional analysis, CASA, flow cytometry and mtDNA content (real-time PCR). The mean (±SD) number of mtDNA copies equalled 14 ± 9 and varied from 3 to 64. Considering the great number of sperm parameters monitored in this study, only few of them were correlated with the mtDNA content: ejaculate volume (a positive correlation), the amplitude of lateral head displacement (ALH; a negative correlation) and the high mitochondrial activity index (a negative correlation). The stallion age was not correlated with the mtDNA copy number. This study provides the first set of data on mtDNA content in equine sperm and confirms phenomena previously described for humans and dog on associations between sperm mtDNA content and selected motility parameters monitored by the CASA. Basing our study on spermatozoa from fertile stallions could however limit the extent of detected associations. PMID:27037507

  14. Photocopy of drawing (this photograph is and 8' x10' copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is and 8' x10' copy of an 8' x 10' negative; 1993 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Repair chimney, building No. 47, architectural elevations, exterior plan, details, genera notes, sheet 2 of 3 - U.S. Naval Air Station, Power Plant, 328 South Avenue, Pensacola, Escambia County, FL

  15. Photocopy of drawing (this photograph is and 8' x10' copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is and 8' x10' copy of an 8' x 10' negative; 1973 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Demolition of equipment, building No. 47, plans, sheet 1 of 1 - U.S. Naval Air Station, Power Plant, 328 South Avenue, Pensacola, Escambia County, FL

  16. Photocopy of drawing (this photograph is and 8' x10' copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is and 8' x10' copy of an 8' x 10' negative; 1965 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Structural repairs to building No. 47, column replacement and insulation repair, sheet 4 of 5 - U.S. Naval Air Station, Power Plant, 328 South Avenue, Pensacola, Escambia County, FL

  17. Photocopy of drawing (this photograph is and 8' x10' copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is and 8' x10' copy of an 8' x 10' negative; 1941 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Building No. 47, new office space, plan, elevations, section and details, sheet 1 of 2 - U.S. Naval Air Station, Power Plant, 328 South Avenue, Pensacola, Escambia County, FL

  18. Photocopy of drawing (this photograph is and 8' x10' copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is and 8' x10' copy of an 8' x 10' negative; 1980 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Modifications to office space, building No. 47 plans, sections and details, general notes, sheet 2 of 3 - U.S. Naval Air Station, Power Plant, 328 South Avenue, Pensacola, Escambia County, FL

  19. Photocopy of drawing (this photograph is and 8' x10' copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is and 8' x10' copy of an 8' x 10' negative; 1939 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Central power plant, installation of turbo-alternator and air compressor, plan above basement, sheet 1 of 6 - U.S. Naval Air Station, Power Plant, 328 South Avenue, Pensacola, Escambia County, FL

  20. Photocopy of drawing (this photograph is and 8' x10' copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is and 8' x10' copy of an 8' x 10' negative; 1907 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Plan showing floor for basement and support for machinery foundations, central power house building No. 47 - U.S. Naval Air Station, Power Plant, 328 South Avenue, Pensacola, Escambia County, FL

  1. Photocopy of drawing (this photograph is and 8' x10' copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is and 8' x10' copy of an 8' x 10' negative; 1944 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Extension of central power plant, plot plan and details, sheet 2 of 4 - U.S. Naval Air Station, Power Plant, 328 South Avenue, Pensacola, Escambia County, FL

  2. Photocopy of drawing (this photograph is and 8' x10' copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is and 8' x10' copy of an 8' x 10' negative; 1965 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Structural repairs to building No. 47, roof truss system painting, sheet 1 of 5 - U.S. Naval Air Station, Power Plant, 328 South Avenue, Pensacola, Escambia County, FL

  3. Creating Single-Copy Genetic Circuits.

    PubMed

    Lee, Jeong Wook; Gyorgy, Andras; Cameron, D Ewen; Pyenson, Nora; Choi, Kyeong Rok; Way, Jeffrey C; Silver, Pamela A; Del Vecchio, Domitilla; Collins, James J

    2016-07-21

    Synthetic biology is increasingly used to develop sophisticated living devices for basic and applied research. Many of these genetic devices are engineered using multi-copy plasmids, but as the field progresses from proof-of-principle demonstrations to practical applications, it is important to develop single-copy synthetic modules that minimize consumption of cellular resources and can be stably maintained as genomic integrants. Here we use empirical design, mathematical modeling, and iterative construction and testing to build single-copy, bistable toggle switches with improved performance and reduced metabolic load that can be stably integrated into the host genome. Deterministic and stochastic models led us to focus on basal transcription to optimize circuit performance and helped to explain the resulting circuit robustness across a large range of component expression levels. The design parameters developed here provide important guidance for future efforts to convert functional multi-copy gene circuits into optimized single-copy circuits for practical, real-world use. PMID:27425413

  4. 43 CFR 4.437 - Copies of transcript.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Copies of transcript. 4.437 Section 4.437... Fact § 4.437 Copies of transcript. Each party shall pay for any copies of the transcript obtained by him. Unless a summary of the evidence is stipulated to, the Government will file the original copy...

  5. 22 CFR 1471.4 - Copies and service.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Copies and service. 1471.4 Section 1471.4... SERVICE IMPASSE DISPUTES PANEL PROCEDURES OF THE PANEL § 1471.4 Copies and service. Any party submitting a... file an original and one copy with the Panel, shall serve a copy promptly on the other party to...

  6. 22 CFR 1423.6 - Filing and service of copies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Filing and service of copies. 1423.6 Section... LABOR PRACTICE PROCEEDINGS § 1423.6 Filing and service of copies. (a) An original and four (4) copies of the charge together with one copy for each additional charged party named shall be filed with...

  7. 7 CFR 46.42 - Copies of records; how obtained.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Copies of records; how obtained. 46.42 Section 46.42... REGULATIONS (OTHER THAN RULES OF PRACTICE) UNDER THE PERISHABLE AGRICULTURAL COMMODITIES ACT, 1930 Copies of Records § 46.42 Copies of records; how obtained. Copies of records pertaining to licensees under the...

  8. 49 CFR 1310.6 - Furnishing copies of tariff publications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Furnishing copies of tariff publications. 1310.6... REQUIREMENTS FOR HOUSEHOLD GOODS CARRIERS § 1310.6 Furnishing copies of tariff publications. (a) Copies of... copies of tariff publications to interested persons. If a charge is made, the charge must be...

  9. 40 CFR 121.11 - Copies of documents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Copies of documents. 121.11 Section....11 Copies of documents. (a) Upon receipt from an applicant of an application for a license or permit... copy of the application to the appropriate certifying agency and two copies to the...

  10. 33 CFR 401.94 - Keeping copies of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Keeping copies of regulations..., DEPARTMENT OF TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations General § 401.94 Keeping copies of regulations. (a) A copy of these Regulations (subpart A of part 401), a copy of the vessel's valid...

  11. 22 CFR 1429.25 - Number of copies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Number of copies. 1429.25 Section 1429.25... AND GENERAL REQUIREMENTS General Requirements § 1429.25 Number of copies. Unless otherwise provided by... therewith, shall be submitted in an original and four (4) copies. A clean copy capable of being used as...

  12. Using copy milling technology in restorative dentistry.

    PubMed

    McLaren, E A

    1997-03-01

    A technique for the fabrication of copy milled ceramic restorations has been presented. Both direct and indirect fabrication techniques of inlays, onlays, veneers, and crowns are possible. A copy milling machine can mill accurately fitting restorations with a marginal gap of 50 microns. The machine uses premanufactured porcelain blanks, which have improved physical properties over conventional porcelains used in standard techniques. Recently, the ability to mill In-Ceram crowns from presintered alumina blocks and Spinell crowns from alumina/magnesia blocks has been added to the system. The copings are veneered with aluminous porcelain as in the conventional In-Ceram technique.

  13. The Effects of Answer Copying on the Ability Level Estimates of Cheater Examinees in Answer Copying Pairs

    ERIC Educational Resources Information Center

    Zopluoglu, Cengiz; Davenport, Ernest C., Jr.

    2011-01-01

    The purpose of this study was to examine the effects of answer copying on the ability level estimates of cheater examinees in answer copying pairs. The study generated answer copying pairs for each of 1440 conditions, source ability (12) x cheater ability (12) x amount of copying (10). The average difference between the ability level estimates…

  14. DUF1220 copy number is associated with schizophrenia risk and severity: implications for understanding autism and schizophrenia as related diseases.

    PubMed

    Searles Quick, V B; Davis, J M; Olincy, A; Sikela, J M

    2015-01-01

    The copy number of DUF1220, a protein domain implicated in human brain evolution, has been linearly associated with autism severity. Given the possibility that autism and schizophrenia are related disorders, the present study examined DUF1220 copy number variation in schizophrenia severity. There are notable similarities between autism symptoms and schizophrenia negative symptoms, and divergence between autism symptoms and schizophrenia positive symptoms. We therefore also examined DUF1220 copy number in schizophrenia subgroups defined by negative and positive symptom features, versus autistic individuals and controls. In the schizophrenic population (N=609), decreased DUF1220 copy number was linearly associated with increasing positive symptom severity (CON1 P=0.013, HLS1 P=0.0227), an association greatest in adult-onset schizophrenia (CON1 P=0.00155, HLS1 P=0.00361). In schizophrenic males, DUF1220 CON1 subtype copy number increase was associated with increased negative symptom severity (P=0.0327), a finding similar to that seen in autistic populations. Subgroup analyses demonstrated that schizophrenic individuals with predominantly positive symptoms exhibited reduced CON1 copy number compared with both controls (P=0.0237) and schizophrenic individuals with predominantly negative symptoms (P=0.0068). These findings support the view that (1) autism and schizophrenia exhibit both opposing and partially overlapping phenotypes and may represent a disease continuum, (2) variation in DUF1220 copy number contributes to schizophrenia disease risk and to the severity of both disorders, and (3) schizophrenia and autism may be, in part, a harmful by-product of the rapid and extreme evolutionary increase in DUF1220 copy number in the human species. PMID:26670282

  15. DUF1220 copy number is associated with schizophrenia risk and severity: implications for understanding autism and schizophrenia as related diseases

    PubMed Central

    Searles Quick, V B; Davis, J M; Olincy, A; Sikela, J M

    2015-01-01

    The copy number of DUF1220, a protein domain implicated in human brain evolution, has been linearly associated with autism severity. Given the possibility that autism and schizophrenia are related disorders, the present study examined DUF1220 copy number variation in schizophrenia severity. There are notable similarities between autism symptoms and schizophrenia negative symptoms, and divergence between autism symptoms and schizophrenia positive symptoms. We therefore also examined DUF1220 copy number in schizophrenia subgroups defined by negative and positive symptom features, versus autistic individuals and controls. In the schizophrenic population (N=609), decreased DUF1220 copy number was linearly associated with increasing positive symptom severity (CON1 P=0.013, HLS1 P=0.0227), an association greatest in adult-onset schizophrenia (CON1 P=0.00155, HLS1 P=0.00361). In schizophrenic males, DUF1220 CON1 subtype copy number increase was associated with increased negative symptom severity (P=0.0327), a finding similar to that seen in autistic populations. Subgroup analyses demonstrated that schizophrenic individuals with predominantly positive symptoms exhibited reduced CON1 copy number compared with both controls (P=0.0237) and schizophrenic individuals with predominantly negative symptoms (P=0.0068). These findings support the view that (1) autism and schizophrenia exhibit both opposing and partially overlapping phenotypes and may represent a disease continuum, (2) variation in DUF1220 copy number contributes to schizophrenia disease risk and to the severity of both disorders, and (3) schizophrenia and autism may be, in part, a harmful by-product of the rapid and extreme evolutionary increase in DUF1220 copy number in the human species. PMID:26670282

  16. Copyright & Home Copying. Technology Challenges the Law.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Office of Technology Assessment.

    Home recording technologies allow today's consumer to make near-perfect copies of recorded music, television shows, movies, and other copyrighted works for private use at home. With the advance of digital recording equipment, consumers will be able to reproduce these copyrighted works with even greater accuracy. This is an issue of great concern…

  17. Teaching Ad Copy--I and II.

    ERIC Educational Resources Information Center

    Welty, Ward; Vanden Bergh, Bruce G.

    1981-01-01

    Ward Welty notes that the standard advertising course could be improved by including a unit of study in rhetoric, especially Aristotelian rhetoric. Bruce Vanden Bergh reports on research on the differences in creating advertising copy for radio versus the visual media of magazines, newspapers, and television. (RL)

  18. 36 CFR 703.20 - File copies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 703.20 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library... file of copies of all demands served on the Library and deciding officials' responses....

  19. 36 CFR 703.20 - File copies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 703.20 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library... file of copies of all demands served on the Library and deciding officials' responses....

  20. 36 CFR 703.20 - File copies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 703.20 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Testimony by Employees and Production of Documents in Certain Legal Proceedings Where the Library... file of copies of all demands served on the Library and deciding officials' responses....

  1. Do Scribes Learn? Copying and Information Use.

    ERIC Educational Resources Information Center

    McGregor, Joy H.; Streitenberger, Denise C.

    1998-01-01

    Discusses two field studies that observed the behavior of 11th-grade students as they used reference sources to write research papers. Topics include plagiarism, citing sources correctly, paraphrasing, and the intervention role of the teacher of information skills and composition. Examples of copying are appended. (Author/LRW)

  2. Copy to contiguous example using C descriptor

    SciTech Connect

    Rasmussen, Craig E

    2011-01-18

    In N1838-2 there is an example of how to use the CFI-cdesc-t type in a C implementation of a BIND (C) interface. This paper provides another example of using the CFI-cdesc-t type in C. This new example provides code to copy an array (possibly noncontiguous) into a contiguous buffer.

  3. COPI selectively drives maturation of the early Golgi

    DOE PAGES

    Papanikou, Effrosyni; Day, Kasey J.; Austin, Jotham; Glick, Benjamin S.

    2015-12-28

    COPI coated vesicles carry material between Golgi compartments, but the role of COPI in the secretory pathway has been ambiguous. Previous studies of thermosensitive yeast COPI mutants yielded the surprising conclusion that COPI was dispensable both for the secretion of certain proteins and for Golgi cisternal maturation. To revisit these issues, we optimized the anchor-away method, which allows peripheral membrane proteins such as COPI to be sequestered rapidly by adding rapamycin. Video fluorescence microscopy revealed that COPI inactivation causes an early Golgi protein to remain in place while late Golgi proteins undergo cycles of arrival and departure. These dynamics generatemore » partially functional hybrid Golgi structures that contain both early and late Golgi proteins, explaining how secretion can persist when COPI has been inactivated. Our findings suggest that cisternal maturation involves a COPI-dependent pathway that recycles early Golgi proteins, followed by multiple COPI-independent pathways that recycle late Golgi proteins.« less

  4. Credit WCT. Photographic copy of photograph, view looking northeast down ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, view looking northeast down onto new Dd test station from Test Stand "D" tower. Hatch of Dd test cell is open, and a test engine sits on a dolly nearby awaiting mounting. Note the water-cooled diffuser on the east end of the test chamber; this was soon replaced with a new diffuser and a steam-driven ejector for simulated high-altitude tests. A closed circuit television camera is mounted on the west end of the test cell. At the lower left of the view are fuel and oxidizer run tanks which supply propellants for test runs. (JPL negative no. 384-2650-A, 8 February 1961) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  5. Clinical relevance of copy number profiling in oral and oropharyngeal squamous cell carcinoma.

    PubMed

    van Kempen, Pauline M W; Noorlag, Rob; Braunius, Weibel W; Moelans, Cathy B; Rifi, Widad; Savola, Suvi; Koole, Ronald; Grolman, Wilko; van Es, Robert J J; Willems, Stefan M

    2015-10-01

    Current conventional treatment modalities in head and neck squamous cell carcinoma (HNSCC) are nonselective and have shown to cause serious side effects. Unraveling the molecular profiles of head and neck cancer may enable promising clinical applications that pave the road for personalized cancer treatment. We examined copy number status in 36 common oncogenes and tumor suppressor genes in a cohort of 191 oropharyngeal squamous cell carcinomas (OPSCC) and 164 oral cavity squamous cell carcinomas (OSCC) using multiplex ligation probe amplification. Copy number status was correlated with human papillomavirus (HPV) status in OPSCC, with occult lymph node status in OSCC and with patient survival. The 11q13 region showed gain or amplifications in 59% of HPV-negative OPSCC, whereas this amplification was almost absent in HPV-positive OPSCC. Additionally, in clinically lymph node-negative OSCC (Stage I-II), gain of the 11q13 region was significantly correlated with occult lymph node metastases with a negative predictive value of 81%. Multivariate survival analysis revealed a significantly decreased disease-free survival in both HPV-negative and HPV-positive OPSCC with a gain of Wnt-induced secreted protein-1. Gain of CCND1 showed to be an independent predictor for worse survival in OSCC. These results show that copy number aberrations, mainly of the 11q13 region, may be important predictors and prognosticators which allow for stratifying patients for personalized treatment of HNSCC. PMID:26194878

  6. Digital authentication with copy-detection patterns

    NASA Astrophysics Data System (ADS)

    Picard, Justin

    2004-06-01

    Technologies for making high-quality copies of documents are getting more available, cheaper, and more efficient. As a result, the counterfeiting business engenders huge losses, ranging to 5% to 8% of worldwide sales of brand products, and endangers the reputation and value of the brands themselves. Moreover, the growth of the Internet drives the business of counterfeited documents (fake IDs, university diplomas, checks, and so on), which can be bought easily and anonymously from hundreds of companies on the Web. The incredible progress of digital imaging equipment has put in question the very possibility of verifying the authenticity of documents: how can we discern genuine documents from seemingly "perfect" copies? This paper proposes a solution based on creating digital images with specific properties, called a Copy-detection patterns (CDP), that is printed on arbitrary documents, packages, etc. CDPs make an optimal use of an "information loss principle": every time an imae is printed or scanned, some information is lost about the original digital image. That principle applies even for the highest quality scanning, digital imaging, printing or photocopying equipment today, and will likely remain true for tomorrow. By measuring the amount of information contained in a scanned CDP, the CDP detector can take a decision on the authenticity of the document.

  7. Gene copy number and cell cycle arrest

    NASA Astrophysics Data System (ADS)

    Ghosh, Bhaswar; Bose, Indrani

    2006-03-01

    The cell cycle is an orderly sequence of events which ultimately lead to the division of a single cell into two daughter cells. In the case of DNA damage by radiation or chemicals, the damage checkpoints in the G1 and G2 phases of the cell cycle are activated. This results in an arrest of the cell cycle so that the DNA damage can be repaired. Once this is done, the cell continues with its usual cycle of activity. We study a mathematical model of the DNA damage checkpoint in the G2 phase which arrests the transition from the G2 to the M (mitotic) phase of the cell cycle. The tumor suppressor protein p53 plays a key role in activating the pathways leading to cell cycle arrest in mammalian systems. If the DNA damage is severe, the p53 proteins activate other pathways which bring about apoptosis, i.e., programmed cell death. Loss of the p53 gene results in the proliferation of cells containing damaged DNA, i.e., in the growth of tumors which may ultimately become cancerous. There is some recent experimental evidence which suggests that the mutation of a single copy of the p53 gene (in the normal cell each gene has two identical copies) is sufficient to trigger the formation of tumors. We study the effect of reducing the gene copy number of the p53 and two other genes on cell cycle arrest and obtain results consistent with experimental observations.

  8. 19 CFR 151.64 - Extra copy of entry summary.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.64 Extra copy of entry summary. One extra copy of the entry summary covering wool or hair subject to duty at a rate...

  9. 19 CFR 151.64 - Extra copy of entry summary.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.64 Extra copy of entry summary. One extra copy of the entry summary covering wool or hair subject to duty at a rate...

  10. 19 CFR 151.64 - Extra copy of entry summary.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.64 Extra copy of entry summary. One extra copy of the entry summary covering wool or hair subject to duty at a rate...

  11. 19 CFR 151.64 - Extra copy of entry summary.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.64 Extra copy of entry summary. One extra copy of the entry summary covering wool or hair subject to duty at a rate...

  12. A Simulation Model for Purchasing Duplicate Copies in a Library

    ERIC Educational Resources Information Center

    Arms, W. Y.; Walter, T. P.

    1974-01-01

    A method of estimating the number of duplicate copies of books needed based on a computer simulation which takes into account number of copies available, number of loans, total underlying demand, satisfaction level, percentage time on shelf. (LS)

  13. 13. PHOTOGRAPHIC COPY OF HISTORIC POSTCARD, THE HOSE FIGHT, HOMECOMING, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. PHOTOGRAPHIC COPY OF HISTORIC POSTCARD, THE HOSE FIGHT, HOMECOMING, 1911 (Original copy in possession of Mrs. Elizabeth C. Arnesi) - Bridge Street Bridge, Spanning Grand River at Bridge Street, Portland, Ionia County, MI

  14. 19 CFR 151.64 - Extra copy of entry summary.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.64 Extra copy of entry summary. One extra copy of the entry summary covering wool or hair subject to duty at a rate...

  15. 40 CFR 262.22 - Number of copies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.22 Number of copies. The manifest consists of at least the number of copies which will provide the generator, each transporter, and the owner... returned to the generator....

  16. 40 CFR 262.22 - Number of copies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.22 Number of copies. The manifest consists of at least the number of copies which will provide the generator, each transporter, and the owner... returned to the generator....

  17. 40 CFR 262.22 - Number of copies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.22 Number of copies. The manifest consists of at least the number of copies which will provide the generator, each transporter, and the owner... returned to the generator....

  18. 40 CFR 262.22 - Number of copies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.22 Number of copies. The manifest consists of at least the number of copies which will provide the generator, each transporter, and the owner... returned to the generator....

  19. 40 CFR 262.22 - Number of copies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.22 Number of copies. The manifest consists of at least the number of copies which will provide the generator, each transporter, and the owner... returned to the generator....

  20. To copy or not to copy: A compile-time technique for assessing when data copying should be used to eliminate cache conflicts

    SciTech Connect

    Temam, O.; Granston, E.D.; Jalby, W.

    1993-12-31

    In recent years, loop tiling has become an increasingly popular technique for increasing cache effectiveness. This is accomplished by transforming a loop nest so that the temporal and spatial locality can be better exploited for a given cache size. However, this optimization only targets the reduction of capacity misses. As recently demonstrated by several groups of researchers, conflict misses can still preclude effective cache utilization. Moreover, the severity of cache conflicts can vary greatly with slight variations in problem size and starting addresses, making performance difficult to even predict, let alone optimize. To reduce conflict misses, data copying has been proposed. With this technique, data layout in cache is adjusted by copying array tiles into temporary arrays that exhibit better cache behavior. Although copying has been proposed as the panacea to the problem of cache conflicts, this solution experiences a cost proportional to the amount of data being copied. To date, there has been no discussion regarding either this tradeoff or the problem of determining what and when to copy. In this paper, the authors present a compile-time technique for making this determination, and present a selective copying strategy based on this methodology. Preliminary experimental results demonstrate that, because of the sensitivity of cache conflicts to small changes in problem size and base addresses, selective copying can lead to better overall performance than either no copying, complete copying, or copying based on manually applied heuristics.

  1. Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines.

    PubMed

    Houldcroft, Charlotte J; Petrova, Velislava; Liu, Jimmy Z; Frampton, Dan; Anderson, Carl A; Gall, Astrid; Kellam, Paul

    2014-01-01

    Lymphoblastoid cell lines (LCLs) are commonly used in molecular genetics, supplying DNA for the HapMap and 1000 Genomes Projects, used to test chemotherapeutic agents, and informing the basis of a number of population genetics studies of gene expression. The process of transforming human B cells into LCLs requires the presence of Epstein-Barr virus (EBV), a double-stranded DNA virus which through B-cell immortalisation maintains an episomal virus genome in every cell of an LCL at variable copy numbers. Previous studies have reported that EBV alters host-gene expression and EBV copy number may be under host genetic control. We performed a genome-wide association study of EBV genome copy number in LCLs and found the phenotype to be highly heritable, although no individual SNPs achieved a significant association with EBV copy number. The expression of two host genes (CXCL16 and AGL) was positively correlated and expression of ADARB2 was negatively correlated with EBV copy number in a genotype-independent manner. This study shows an association between EBV copy number and the gene expression profile of LCLs, and suggests that EBV copy number should be considered as a covariate in future studies of host gene expression in LCLs.

  2. 42 CFR 456.612 - Copies of reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Copies of reports. 456.612 Section 456.612 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Institutions for Mental Diseases § 456.612 Copies of reports. The agency must send a copy of each...

  3. 27 CFR 18.64 - Photographic copies of records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Photographic copies of records. 18.64 Section 18.64 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Reports § 18.64 Photographic copies of records. Proprietors may record, copy, or reproduce...

  4. 27 CFR 31.192 - Photographic copies of records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Photographic copies of records. 31.192 Section 31.192 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Records and Files § 31.192 Photographic copies of records. (a) General. Dealers may record, copy,...

  5. 27 CFR 22.165 - Photographic copies of records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Photographic copies of records. 22.165 Section 22.165 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Transactions § 22.165 Photographic copies of records. (a) General. Permittees may record, copy, or...

  6. 49 CFR 390.31 - Copies of records or documents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... retention period. (b) To be acceptable in lieu of original records, photographic copies of records must meet the following minimum requirements: (1) Photographic copies shall be no less readily accessible than... facilities shall be available to locate, identify, read, and reproduce such photographic copies. (2)...

  7. 27 CFR 19.725 - Photographic copies of records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Photographic copies of records. 19.725 Section 19.725 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Photographic copies of records. (a) Application. Proprietors who desire to record, copy or reproduce...

  8. 27 CFR 20.268 - Photographic copies of records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Photographic copies of records. 20.268 Section 20.268 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Reports § 20.268 Photographic copies of records. (a) General. Permittees may record, copy, or...

  9. Syllables as Functional Units in a Copying Task

    ERIC Educational Resources Information Center

    Kandel, Sonia; Valdois, Sylviane

    2006-01-01

    This research used a copying task to study spelling acquisition from a perception and action perspective. First to fifth graders copied words and pseudo-words on a digitiser. Simultaneously, a camera registered the children's gaze lifts. First and second graders copied the first syllable and then produced a gaze lift to obtain information on the…

  10. Readability as a Factor in Magazine Ad Copy Recall.

    ERIC Educational Resources Information Center

    Wesson, David A.

    1989-01-01

    Examines the relationship between advertising copy readability and advertising effectiveness. Finds that recall is improved when the copy style is either fairly easy or fairly hard to read. Suggests the value of considering copy readability as a potential contributor, though a minor one, to the success of magazine advertising. (RS)

  11. 1 CFR 18.1 - Original and copies required.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Original and copies required. 18.1 Section 18.1... PROCESSING OF DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.1 Original and copies... two duplicate originals or certified copies. 1 However, if the document is printed or processed...

  12. 1 CFR 18.1 - Original and copies required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Original and copies required. 18.1 Section 18.1... PROCESSING OF DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.1 Original and copies... two duplicate originals or certified copies. 1 However, if the document is printed or processed...

  13. 1 CFR 18.1 - Original and copies required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Original and copies required. 18.1 Section 18.1... PROCESSING OF DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.1 Original and copies... two duplicate originals or certified copies. 1 However, if the document is printed or processed...

  14. 75 FR 4031 - Streamlining Hard-Copy Postage Statement Processing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ... 111 Streamlining Hard-Copy Postage Statement Processing AGENCY: Postal Service\\TM\\. ACTION: Proposed... Postal Service, Domestic Mail Manual (DMM ), to reflect changes in the processing of hard-copy postage... complete the ``USPS Use Only'' section of, or round date, hard-copy postage statements...

  15. 47 CFR 3.25 - Number of copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Number of copies. 3.25 Section 3.25 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL AUTHORIZATION AND ADMINISTRATION OF ACCOUNTING... copies. One original and one copy of FCC Form 44, “Application For Certification As An...

  16. 7 CFR 1200.12 - Copies of the transcript.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Copies of the transcript. 1200.12 Section 1200.12... Governing Proceedings To Formulate and Amend an Order § 1200.12 Copies of the transcript. (a) During the period in which the proceeding has an active status in the Department, a copy of the transcript...

  17. 26 CFR 601.525 - Certification of copies of documents.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 20 2010-04-01 2010-04-01 false Certification of copies of documents. 601.525... Alcohol, Tobacco, and Firearms Activities § 601.525 Certification of copies of documents. The provisions of paragraph (e) of § 601.504 with respect to certification of copies are applicable to a power...

  18. 46 CFR 67.539 - Copies of instruments and documents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... VESSELS DOCUMENTATION OF VESSELS Fees § 67.539 Copies of instruments and documents. The fee charged for furnishing a copy of any instrument or document is calculated in the same manner as described in 49 CFR 7.95. ... 46 Shipping 2 2010-10-01 2010-10-01 false Copies of instruments and documents. 67.539 Section...

  19. 40 CFR 374.5 - Copy of complaint.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Copy of complaint. 374.5 Section 374.5... COMMUNITY RIGHT-TO-KNOW PROGRAMS PRIOR NOTICE OF CITIZEN SUITS § 374.5 Copy of complaint. At the time of filing an action under this Act, the plaintiff must provide a copy of the complaint to the...

  20. 47 CFR 78.67 - Copies of rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Copies of rules. 78.67 Section 78.67... SERVICE General Operating Requirements § 78.67 Copies of rules. The licensee of a CARS station shall have a current copy of this part 78, and, in cases where aeronautical obstruction marking of antennas...

  1. 7 CFR 46.8 - Copies of licenses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Copies of licenses. 46.8 Section 46.8 Agriculture... THAN RULES OF PRACTICE) UNDER THE PERISHABLE AGRICULTURAL COMMODITIES ACT, 1930 Licenses § 46.8 Copies of licenses. Copies of licenses may be issued upon request and upon the payment of a fee of...

  2. 18 CFR 385.1904 - Copies of transcripts (Rule 1904).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Copies of transcripts... § 385.1904 Copies of transcripts (Rule 1904). The Commission will cause to be made a stenographic record of public hearings and such copies of the transcript thereof as it requires for its own...

  3. 12 CFR 269b.730 - Number of copies; form.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Number of copies; form. 269b.730 Section 269b... SYSTEM CHARGES OF UNFAIR LABOR PRACTICES General Rules § 269b.730 Number of copies; form. Except as... copies in addition to the original. All matters filed shall be printed, typed, or otherwise...

  4. 7 CFR 900.11 - Copies of the transcript.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Copies of the transcript. 900.11 Section 900.11....11 Copies of the transcript. (a) During the period in which the proceeding has an active status in the Department, a copy of the transcript and exhibits shall be kept on file in the office of...

  5. 45 CFR 1309.40 - Copies of documents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Copies of documents. 1309.40 Section 1309.40 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES... § 1309.40 Copies of documents. Certified copies of the deed, lease, loan instrument, mortgage, and...

  6. 44 CFR 5.85 - Authentication and attestation of copies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... attestation of copies. 5.85 Section 5.85 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT... Authentication and attestation of copies. The Administrator, Deputy Administrators, Regional Administrators... name of the Administrator to authenticate and attest for copies or reproductions of...

  7. 5 CFR 2423.6 - Filing and service of copies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Filing and service of copies. 2423.6..., Investigating, Resolving, and Acting on Charges § 2423.6 Filing and service of copies. (a) Where to file. A... Charging Party is not required to file an original copy of the charge with the Region. A Charging...

  8. 40 CFR 264.53 - Copies of contingency plan.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Copies of contingency plan. 264.53 Section 264.53 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... Contingency Plan and Emergency Procedures § 264.53 Copies of contingency plan. A copy of the contingency...

  9. 37 CFR 360.5 - Copies of claims.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Copies of claims. 360.5... § 360.5 Copies of claims. A claimant shall, for each claim submitted to the Copyright Royalty Board by hand delivery or by mail, file an original and one copy of the claim to cable royalty fees....

  10. 45 CFR 2106.4 - Requests for copies of records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Requests for copies of records. 2106.4 Section... FOR COMPLIANCE WITH 5 U.S.C. 552a, THE PRIVACY ACT OF 1974 § 2106.4 Requests for copies of records. Rules governing requests for copies of records are the same as those for the granting of access to...

  11. 40 CFR 51.281 - Copies of rules and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Copies of rules and regulations. 51.281... Requirements § 51.281 Copies of rules and regulations. Emission limitations and other measures necessary for... requirements of subpart L must be adopted as rules and regulations enforceable by the State agency. Copies...

  12. 34 CFR 5.52 - Copies of records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Copies of records. 5.52 Section 5.52 Education Office.... L. 90-23 (Eff. until 7-14-10) Procedures for Requesting Access to Records § 5.52 Copies of records. Copies of available records shall be produced as promptly as possible upon receipt of the fee...

  13. 33 CFR 88.05 - Copy of rules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Copy of rules. 88.05 Section 88... RULES ANNEX V: PILOT RULES § 88.05 Copy of rules. The operator of each self-propelled vessel 12 meters or more in length shall carry on board and maintain for ready reference a copy of the...

  14. 19 CFR 210.55 - Content of service copies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Content of service copies. 210.55 Section 210.55... TRADE ADJUDICATION AND ENFORCEMENT Temporary Relief § 210.55 Content of service copies. (a) Any purported confidential business information that is deleted from the nonconfidential service copies of...

  15. 27 CFR 478.95 - Certified copy of license.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Certified copy of license... Conduct of Business § 478.95 Certified copy of license. The license furnished to each person licensed... the licensee desires an additional copy of the license for certification (instead of making...

  16. 47 CFR 95.673 - Copy of rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Copy of rules. 95.673 Section 95.673... SERVICES Technical Regulations Additional Certification Requirements for Cb Transmitters § 95.673 Copy of rules. A copy of part 95, subpart D, of the FCC Rules, current at the time of packing of the...

  17. 40 CFR 35.935-10 - Copies of contract documents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Copies of contract documents. 35.935-10... Copies of contract documents. In addition to the notification of project changes under § 30.900 of this chapter, a grantee must promptly submit to the Regional Administrator a copy of any prime contract...

  18. 49 CFR 1312.13 - Furnishing copies of tariff publications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... with 49 CFR 1312.13 has been made. (d) Charges. (1) If any charge is made, the charge for copies of... 49 Transportation 9 2010-10-01 2010-10-01 false Furnishing copies of tariff publications. 1312.13... CARRIER IN NONCONTIGUOUS DOMESTIC TRADE § 1312.13 Furnishing copies of tariff publications....

  19. 47 CFR 1.356 - Copies of exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Copies of exhibits. 1.356 Section 1.356....356 Copies of exhibits. No document or exhibit, or part thereof, shall be received as, or admitted in... offered in evidence, copies shall be furnished to other counsel unless the presiding officer...

  20. 37 CFR 360.14 - Copies of claims.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Copies of claims. 360.14... Claims § 360.14 Copies of claims. A claimant shall, for each claim submitted to the Copyright Royalty Board by hand delivery or by mail, file an original and one copy of the claim to satellite...

  1. 29 CFR 1905.7 - Form of documents; subscription; copies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Form of documents; subscription; copies. 1905.7 Section...; subscription; copies. (a) No particular form is prescribed for applications and other papers which may be filed.... An original and six copies of any application or other papers shall be filed. The original shall...

  2. 46 CFR 502.168 - Copies of data or evidence.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Copies of data or evidence. 502.168 Section 502.168... Hearings; Presiding Officers; Evidence § 502.168 Copies of data or evidence. Every person compelled to submit data or evidence shall be entitled to retain or, on payment of proper costs, procure a copy...

  3. 33 CFR 72.01-40 - Single copies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Single copies. 72.01-40 Section 72.01-40 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION MARINE INFORMATION Notices to Mariners § 72.01-40 Single copies. Single copies of the “Notice...

  4. 49 CFR 1001.2 - Certified copies of records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Certified copies of records. 1001.2 Section 1001.2... OF TRANSPORTATION GENERAL RULES AND REGULATIONS INSPECTION OF RECORDS § 1001.2 Certified copies of records. Copies of and extracts from public records will be certified by the Records Officer....

  5. 30 CFR 47.72 - Cost for copies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Cost for copies. 47.72 Section 47.72 Mineral... COMMUNICATION (HazCom) Making HazCom Information Available § 47.72 Cost for copies. (a) The operator must provide the first copy and each revision of the HazCom material without cost. (b) Fees for a...

  6. 47 CFR 78.67 - Copies of rules.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Copies of rules. 78.67 Section 78.67 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES CABLE TELEVISION RELAY SERVICE General Operating Requirements § 78.67 Copies of rules. The licensee of a CARS station shall have a current copy of this part 78, and,...

  7. 47 CFR 78.67 - Copies of rules.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Copies of rules. 78.67 Section 78.67 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES CABLE TELEVISION RELAY SERVICE General Operating Requirements § 78.67 Copies of rules. The licensee of a CARS station shall have a current copy of this part 78, and,...

  8. 47 CFR 78.67 - Copies of rules.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Copies of rules. 78.67 Section 78.67 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES CABLE TELEVISION RELAY SERVICE General Operating Requirements § 78.67 Copies of rules. The licensee of a CARS station shall have a current copy of this part 78, and,...

  9. 47 CFR 78.67 - Copies of rules.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Copies of rules. 78.67 Section 78.67 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES CABLE TELEVISION RELAY SERVICE General Operating Requirements § 78.67 Copies of rules. The licensee of a CARS station shall have a current copy of this part 78, and,...

  10. 18 CFR 33.8 - Number of copies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Number of copies. 33.8 Section 33.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF... Number of copies. An original and eight copies of the application under this part must be submitted....

  11. 1 CFR 18.1 - Original and copies required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Original and copies required. 18.1 Section 18.1... PROCESSING OF DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.1 Original and copies... two duplicate originals or certified copies. 1 However, if the document is printed or processed...

  12. 1 CFR 18.1 - Original and copies required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Original and copies required. 18.1 Section 18.1... PROCESSING OF DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.1 Original and copies... two duplicate originals or certified copies. 1 However, if the document is printed or processed...

  13. 65. March 1978. Copy of enlargement from original 11Omm blackandwhite ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    65. March 1978. Copy of enlargement from original 11Omm black-and-white aerial negative from Sortie 414, made by United States Air Force, Tactical Reconaissance Wing, Ninth Air Force, at Shaw Air Force Base, Sumter, South Carolina. Overhead aerial view of Borough House with surrounding grounds and adjacent properties. - Borough House, West Side State Route 261, about .1 mile south side of junction with old Garners Ferry Road, Stateburg, Sumter County, SC

  14. Photocopy of drawing (this photograph is and 8' x10' copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (this photograph is and 8' x10' copy of an 8' x 10' negative; 1940 original architectural drawing located at Building No. 458, NAS Pensacola, Florida) Central power plant building No. 47, electrical work, salt water pumps, auxiliary bus and fire pump, plan, details and changes, sheet 1 of 1. - U.S. Naval Air Station, Power Plant, 328 South Avenue, Pensacola, Escambia County, FL

  15. Copy-choice illegitimate DNA recombination revisited.

    PubMed Central

    d'Alençon, E; Petranovic, M; Michel, B; Noirot, P; Aucouturier, A; Uzest, M; Ehrlich, S D

    1994-01-01

    Nearly precise excision of a transposon related to Tn10 from an Escherichia coli plasmid was used as a model to study illegitimate DNA recombination between short direct repeats. The excision was stimulated 100-1000 times by induction of plasmid single-stranded DNA synthesis and did not involve transfer of DNA from the parental to the progeny molecule. We conclude that it occurred by copy-choice DNA recombination, and propose that other events of recombination between short direct repeats might be a result of the same process. Images PMID:8013470

  16. Digital image forensics for photographic copying

    NASA Astrophysics Data System (ADS)

    Yin, Jing; Fang, Yanmei

    2012-03-01

    Image display technology has greatly developed over the past few decades, which make it possible to recapture high-quality images from the display medium, such as a liquid crystal display(LCD) screen or a printed paper. The recaptured images are not regarded as a separate image class in the current research of digital image forensics, while the content of the recaptured images may have been tempered. In this paper, two sets of features based on the noise and the traces of double JPEG compression are proposed to identify these recaptured images. Experimental results showed that our proposed features perform well for detecting photographic copying.

  17. Getting DNA copy numbers without control samples

    PubMed Central

    2012-01-01

    Background The selection of the reference to scale the data in a copy number analysis has paramount importance to achieve accurate estimates. Usually this reference is generated using control samples included in the study. However, these control samples are not always available and in these cases, an artificial reference must be created. A proper generation of this signal is crucial in terms of both noise and bias. We propose NSA (Normality Search Algorithm), a scaling method that works with and without control samples. It is based on the assumption that genomic regions enriched in SNPs with identical copy numbers in both alleles are likely to be normal. These normal regions are predicted for each sample individually and used to calculate the final reference signal. NSA can be applied to any CN data regardless the microarray technology and preprocessing method. It also finds an optimal weighting of the samples minimizing possible batch effects. Results Five human datasets (a subset of HapMap samples, Glioblastoma Multiforme (GBM), Ovarian, Prostate and Lung Cancer experiments) have been analyzed. It is shown that using only tumoral samples, NSA is able to remove the bias in the copy number estimation, to reduce the noise and therefore, to increase the ability to detect copy number aberrations (CNAs). These improvements allow NSA to also detect recurrent aberrations more accurately than other state of the art methods. Conclusions NSA provides a robust and accurate reference for scaling probe signals data to CN values without the need of control samples. It minimizes the problems of bias, noise and batch effects in the estimation of CNs. Therefore, NSA scaling approach helps to better detect recurrent CNAs than current methods. The automatic selection of references makes it useful to perform bulk analysis of many GEO or ArrayExpress experiments without the need of developing a parser to find the normal samples or possible batches within the data. The method is

  18. Effects of genome-wide copy number variation on expression in mammalian cells

    PubMed Central

    2011-01-01

    Background There is only a limited understanding of the relation between copy number and expression for mammalian genes. We fine mapped cis and trans regulatory loci due to copy number change for essentially all genes using a human-hamster radiation hybrid (RH) panel. These loci are called copy number expression quantitative trait loci (ceQTLs). Results Unexpected findings from a previous study of a mouse-hamster RH panel were replicated. These findings included decreased expression as a result of increased copy number for 30% of genes and an attenuated relationship between expression and copy number on the X chromosome suggesting an Xist independent form of dosage compensation. In a separate glioblastoma dataset, we found conservation of genes in which dosage was negatively correlated with gene expression. These genes were enriched in signaling and receptor activities. The observation of attenuated X-linked gene expression in response to increased gene number was also replicated in the glioblastoma dataset. Of 523 gene deserts of size > 600 kb in the human RH panel, 325 contained trans ceQTLs with -log10 P > 4.1. Recently discovered genes, ultra conserved regions, noncoding RNAs and microRNAs explained only a small fraction of the results, suggesting a substantial portion of gene deserts harbor as yet unidentified functional elements. Conclusion Radiation hybrids are a useful tool for high resolution mapping of cis and trans loci capable of affecting gene expression due to copy number change. Analysis of two independent radiation hybrid panels show agreement in their findings and may serve as a discovery source for novel regulatory loci in noncoding regions of the genome. PMID:22085887

  19. Copying Actions and Copying Outcomes: Social Learning through the Second Year

    ERIC Educational Resources Information Center

    Nielsen, Mark

    2006-01-01

    The present work documents how the logic of a model's demonstration and the communicative cues that the model provides interact with age to influence how children engage in social learning. Children at ages 12, 18, and 24 months (n = 204) watched a model open a series of boxes. Twelve-month-old subjects only copied the specific actions of the…

  20. Imitation in Young Children: When Who Gets Copied Is More Important than What Gets Copied

    ERIC Educational Resources Information Center

    Nielsen, Mark; Blank, Cornelia

    2011-01-01

    Unlike other animals, human children will copy all of an adult's goal-directed actions, including ones that are clearly unnecessary for achieving the demonstrated goal. Here we highlight how social affiliation is key to this species-specific behavior. Preschoolers watched 2 adults retrieve a toy from a novel apparatus. One adult included…

  1. Conditionally Amplifiable BACs: Switching From Single-Copy to High-Copy Vectors and Genomic Clones

    PubMed Central

    Wild, Jadwiga; Hradecna, Zdenka; Szybalski, Waclaw

    2002-01-01

    The widely used, very-low-copy BAC (bacterial artificial chromosome) vectors are the mainstay of present genomic research. The principal advantage of BACs is the high stability of inserted clones, but an important disadvantage is the low yield of DNA, both for vectors alone and when carrying genomic inserts. We describe here a novel class of single-copy/high-copy (SC/HC) pBAC/oriV vectors that retain all the advantages of low-copy BAC vectors, but are endowed with a conditional and tightly controlled oriV/TrfA amplification system that allows: (1) a yield of ∼100 copies of the vector per host cell when conditionally induced with l-arabinose, and (2) analogous DNA amplification (only upon induction and with copy number depending on the insert size) of pBAC/oriV clones carrying >100-kb inserts. Amplifiable clones and libraries facilitate high-throughput DNA sequencing and other applications requiring HC plasmid DNA. To turn on DNA amplification, which is driven by the oriV origin of replication, we used copy-up mutations in the gene trfA whose expression was very tightly controlled by the araC–ParaBAD promoter/regulator system. This system is inducible by l-arabinose, and could be further regulated by glucose and fucose. Amplification of DNA upon induction with l-arabinose and its modulation by glucose are robust and reliable. Furthermore, we discovered that addition of 0.2% d-glucose to the growth medium helped toward the objective of obtaining a real SC state for all BAC systems, thus enhancing the stability of their maintenance, which became equivalent to cloning into the host chromosome. [The following individuals kindly provided reagents, samples or unpublished information as indicated in the paper: F.R. Blattner D. Helinski, S. Valla, F. Schomburg, C. Small, R. Bogden, C. Gaskins, M.P. Mayer, D.C. Schwartz, and O. Azzam.] PMID:12213781

  2. 11. Photocopy of photograph in the collection of Photographic Branch, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photocopy of photograph in the collection of Photographic Branch, Puget Sound Naval Shipyard, Bremerton, WA. Original is labelled: Yard Photo 42. Date unknown, probably 1940's. Photographer unknown. HABS negative is a 4x5' copy negative. Perspective view of NE corner of Building 78. - Puget Sound Naval Shipyard, Administration Building, Farragut Avenue, Bremerton, Kitsap County, WA

  3. Copy Number Variants in pharmacogenetic genes

    PubMed Central

    He, Yijing; Hoskins, Janelle M.; McLeod, Howard L.

    2011-01-01

    Variation in drug efficacy and toxicity remains an important clinical concern. Presently, single nucleotide polymorphisms (SNP) only explain a portion of this problem, even in situations where the pharmacological trait is clearly heritable. The Human CNV Project identified copy number variations (CNVs) across approximately 12% of the human genome, and these CNVs were considered causes of diseases. Although the contribution of CNVs to the pathogenesis of many common diseases is questionable, CNVs play a clear role in drug related genes by altering drug metabolizing and drug response. Here we provide a comprehensive review of the clinical relevance of CNVs to drug efficacy, toxicity, disease prevalence in world populations and discuss the implication of using CNVs as diagnosis in clinical intervention. PMID:21388883

  4. Imperfect mirror copies of the standard model

    NASA Astrophysics Data System (ADS)

    Berryman, Jeffrey M.; de Gouvêa, André; Hernández, Daniel; Kelly, Kevin J.

    2016-08-01

    Inspired by the standard model of particle physics, we discuss a mechanism for constructing chiral, anomaly-free gauge theories. The gauge symmetries and particle content of such theories are identified using subgroups and complex representations of simple anomaly-free Lie groups, such as S O (10 ) or E6. We explore, using mostly S O (10 ) and the 16 representation, several of these "imperfect copies" of the standard model, including U (1 )N theories, S U (5 )⊗U (1 ) theories, S U (4 )⊗U (1 )2 theories with 4-plets and 6-plets, and chiral S U (3 )⊗S U (2 )⊗U (1 ) . A few general properties of such theories are discussed, as is how they might shed light on nonzero neutrino masses, the dark matter puzzle, and other phenomenologically relevant questions.

  5. Double-copy constructions and unitarity cuts

    NASA Astrophysics Data System (ADS)

    Bern, Zvi; Davies, Scott; Nohle, Josh

    2016-05-01

    The duality between color and kinematics enables the construction of multiloop gravity integrands directly from corresponding gauge-theory integrands. This has led to new nontrivial insights into the structure of gravity theories, including the discovery of enhanced ultraviolet cancellations. To continue to gain deeper understandings and probe these new properties, it is crucial to further improve techniques for constructing multiloop gravity integrands. In this paper, we show by example how one can alleviate difficulties encountered at the multiloop level by relaxing the color-kinematics duality conditions to hold manifestly only on unitarity cuts instead of globally on loop integrands. As an example, we use a minimal Ansatz to construct an integrand for the two-loop four-point nonsupersymmetric pure Yang-Mills amplitude in D dimensions that is compatible with these relaxed color-kinematics duality constraints. We then immediately obtain a corresponding gravity integrand through the double-copy procedure. Comments on ultraviolet divergences are also included.

  6. Copy-move forgery detection in digital image

    NASA Astrophysics Data System (ADS)

    Alamro, Loai; Yusoff, Nooraini

    2016-08-01

    Copy-move is considered as one of the most popular kind of digital image tempering, in which one or more parts of a digital image are copied and pasted into different locations. Geometric transformation is among the major challenges in detecting copy-move forgery of a digital image. In such forgery, the copied and moved parts of a forged image are either rotated or/and re-scaled. Hence, in this study we propose a combination of Discrete Wavelet Transform (DWT) and Speeded Up Robust Features (SURF) to detect a copy-move activity. The experiments results prove that the proposed method is superior with overall accuracy 95%. The copy-move attacks in digital image has been successfully detected and the method is also can detect the fraud parts exposed to rotation and scaling issue.

  7. 38 CFR 1.526 - Copies of records and papers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... papers. 1.526 Section 1.526 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... Copies of records and papers. (a) Any person desiring a copy of any record or document in the custody of... plain one-sided paper copies of a standard size (81/2″ × 11″; 81/2″ × 14″; 11″ × 14″) $0.15 per...

  8. 6. Photographic copy of historic photograph (from Wind Cave National ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photographic copy of historic photograph (from Wind Cave National Park), photographer unknown, date unknown. Route 87, Pigtail Bridge, elevation. - Pigtail Bridge, Hot Springs, Fall River County, SD

  9. COPI selectively drives maturation of the early Golgi

    PubMed Central

    Papanikou, Effrosyni; Day, Kasey J; Austin, Jotham; Glick, Benjamin S

    2015-01-01

    COPI coated vesicles carry material between Golgi compartments, but the role of COPI in the secretory pathway has been ambiguous. Previous studies of thermosensitive yeast COPI mutants yielded the surprising conclusion that COPI was dispensable both for the secretion of certain proteins and for Golgi cisternal maturation. To revisit these issues, we optimized the anchor-away method, which allows peripheral membrane proteins such as COPI to be sequestered rapidly by adding rapamycin. Video fluorescence microscopy revealed that COPI inactivation causes an early Golgi protein to remain in place while late Golgi proteins undergo cycles of arrival and departure. These dynamics generate partially functional hybrid Golgi structures that contain both early and late Golgi proteins, explaining how secretion can persist when COPI has been inactivated. Our findings suggest that cisternal maturation involves a COPI-dependent pathway that recycles early Golgi proteins, followed by multiple COPI-independent pathways that recycle late Golgi proteins. DOI: http://dx.doi.org/10.7554/eLife.13232.001 PMID:26709839

  10. Bovine NK-lysin: Copy number variation and functional diversification.

    PubMed

    Chen, Junfeng; Huddleston, John; Buckley, Reuben M; Malig, Maika; Lawhon, Sara D; Skow, Loren C; Lee, Mi Ok; Eichler, Evan E; Andersson, Leif; Womack, James E

    2015-12-29

    NK-lysin is an antimicrobial peptide and effector protein in the host innate immune system. It is coded by a single gene in humans and most other mammalian species. In this study, we provide evidence for the existence of four NK-lysin genes in a repetitive region on cattle chromosome 11. The NK2A, NK2B, and NK2C genes are tandemly arrayed as three copies in ∼30-35-kb segments, located 41.8 kb upstream of NK1. All four genes are functional, albeit with differential tissue expression. NK1, NK2A, and NK2B exhibited the highest expression in intestine Peyer's patch, whereas NK2C was expressed almost exclusively in lung. The four peptide products were synthesized ex vivo, and their antimicrobial effects against both Gram-positive and Gram-negative bacteria were confirmed with a bacteria-killing assay. Transmission electron microcopy indicated that bovine NK-lysins exhibited their antimicrobial activities by lytic action in the cell membranes. In summary, the single NK-lysin gene in other mammals has expanded to a four-member gene family by tandem duplications in cattle; all four genes are transcribed, and the synthetic peptides corresponding to the core regions are biologically active and likely contribute to innate immunity in ruminants. PMID:26668394

  11. Credit WCT. Photographic copy of photograph, low level aerial view ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Photographic copy of photograph, low level aerial view of Test Stand "D," looking due south, after completion of Dd station installation in 1961. Note Test Stand "D" "neutralization pond" to immediate southeast of tower. A steel barrier north of and parallel to the Dd station separates fuel run tanks (on south side obscured from view) from oxidizer run tanks (on north side). Small Dj injector test stand is visible to the immediate left of oxidizer run tanks; it is oriented on a northeast/southwest diagonal to the Dd test station. The large tank to the north of the oxidizer run tanks (near center bottom of view) is an oxidizer storage tank for nitrogen tetroxide. Slender tanks to the northwest of the tower (lower right of view) contain high pressure nitrogen gas. A large vertical tank at the base of the tower contains distilled water for flushing propellant lines. (JPL negative no. 384-2997-B, 12 December 1961) - Jet Propulsion Laboratory Edwards Facility, Test Stand D, Edwards Air Force Base, Boron, Kern County, CA

  12. Photographic copy of photograph, view looking northeast of JPL Edwards ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph, view looking northeast of JPL Edwards Test Station as it looked in 1945. To the immediate right of the Test Stand 'A' tower stands a concrete monitor building or blockhouse (now Building 4203/E-4) for observation and control of tests. Other frame buildings housed workshop and administrative functions. Long structure behind automobiles was designated 4207/E-8 and was used for instrument repair and storage, a cafeteria, machine and welding shops. To the immediate south of 4207/E-8 were 4200/E-1 (used as an office and photographic laboratory) and 4205/E-6 (guardhouse, with fire extinguisher mounted on it). To the northeast of 4205/E-6 was 4204/E-5 (a propellant storage dock, with shed roof). Buildings 4200/E-1, 4205/E-6 and 4207/E-8 were demolished in 1983. Note the absence of trees. (JPL negative no. 383-1297, July 1946) - Jet Propulsion Laboratory Edwards Facility, Edwards Air Force Base, Boron, Kern County, CA

  13. Bovine NK-lysin: Copy number variation and functional diversification

    PubMed Central

    Chen, Junfeng; Huddleston, John; Buckley, Reuben M.; Malig, Maika; Lawhon, Sara D.; Skow, Loren C.; Lee, Mi Ok; Eichler, Evan E.; Andersson, Leif; Womack, James E.

    2015-01-01

    NK-lysin is an antimicrobial peptide and effector protein in the host innate immune system. It is coded by a single gene in humans and most other mammalian species. In this study, we provide evidence for the existence of four NK-lysin genes in a repetitive region on cattle chromosome 11. The NK2A, NK2B, and NK2C genes are tandemly arrayed as three copies in ∼30–35-kb segments, located 41.8 kb upstream of NK1. All four genes are functional, albeit with differential tissue expression. NK1, NK2A, and NK2B exhibited the highest expression in intestine Peyer’s patch, whereas NK2C was expressed almost exclusively in lung. The four peptide products were synthesized ex vivo, and their antimicrobial effects against both Gram-positive and Gram-negative bacteria were confirmed with a bacteria-killing assay. Transmission electron microcopy indicated that bovine NK-lysins exhibited their antimicrobial activities by lytic action in the cell membranes. In summary, the single NK-lysin gene in other mammals has expanded to a four-member gene family by tandem duplications in cattle; all four genes are transcribed, and the synthetic peptides corresponding to the core regions are biologically active and likely contribute to innate immunity in ruminants. PMID:26668394

  14. Accuracy estimation of foamy virus genome copying

    PubMed Central

    Gärtner, Kathleen; Wiktorowicz, Tatiana; Park, Jeonghae; Mergia, Ayalew; Rethwilm, Axel; Scheller, Carsten

    2009-01-01

    Background Foamy viruses (FVs) are the most genetically stable viruses of the retrovirus family. This is in contrast to the in vitro error rate found for recombinant FV reverse transcriptase (RT). To investigate the accuracy of FV genome copying in vivo we analyzed the occurrence of mutations in HEK 293T cell culture after a single round of reverse transcription using a replication-deficient vector system. Furthermore, the frequency of FV recombination by template switching (TS) and the cross-packaging ability of different FV strains were analyzed. Results We initially sequenced 90,000 nucleotides and detected 39 mutations, corresponding to an in vivo error rate of approximately 4 × 10-4 per site per replication cycle. Surprisingly, all mutations were transitions from G to A, suggesting that APOBEC3 activity is the driving force for the majority of mutations detected in our experimental system. In line with this, we detected a late but significant APOBEC3G and 3F mRNA by quantitative PCR in the cells. We then analyzed 170,000 additional nucleotides from experiments in which we co-transfected the APOBEC3-interfering foamy viral bet gene and observed a significant 50% drop in G to A mutations, indicating that APOBEC activity indeed contributes substantially to the foamy viral replication error rate in vivo. However, even in the presence of Bet, 35 out of 37 substitutions were G to A, suggesting that residual APOBEC activity accounted for most of the observed mutations. If we subtract these APOBEC-like mutations from the total number of mutations, we calculate a maximal intrinsic in vivo error rate of 1.1 × 10-5 per site per replication. In addition to the point mutations, we detected one 49 bp deletion within the analyzed 260000 nucleotides. Analysis of the recombination frequency of FV vector genomes revealed a 27% probability for a template switching (TS) event within a 1 kilobase (kb) region. This corresponds to a 98% probability that FVs undergo at least one

  15. Meningitis - gram-negative

    MedlinePlus

    Gram-negative meningitis ... Acute bacterial meningitis can be caused by Gram-negative bacteria. Meningococcal and H. influenzae meningitis are caused by Gram-negative bacteria and are covered in detail in other articles. This article ...

  16. Vocal copying of individually distinctive signature whistles in bottlenose dolphins

    PubMed Central

    King, Stephanie L.; Sayigh, Laela S.; Wells, Randall S.; Fellner, Wendi; Janik, Vincent M.

    2013-01-01

    Vocal learning is relatively common in birds but less so in mammals. Sexual selection and individual or group recognition have been identified as major forces in its evolution. While important in the development of vocal displays, vocal learning also allows signal copying in social interactions. Such copying can function in addressing or labelling selected conspecifics. Most examples of addressing in non-humans come from bird song, where matching occurs in an aggressive context. However, in other animals, addressing with learned signals is very much an affiliative signal. We studied the function of vocal copying in a mammal that shows vocal learning as well as complex cognitive and social behaviour, the bottlenose dolphin (Tursiops truncatus). Copying occurred almost exclusively between close associates such as mother–calf pairs and male alliances during separation and was not followed by aggression. All copies were clearly recognizable as such because copiers consistently modified some acoustic parameters of a signal when copying it. We found no evidence for the use of copying in aggression or deception. This use of vocal copying is similar to its use in human language, where the maintenance of social bonds appears to be more important than the immediate defence of resources. PMID:23427174

  17. 14 CFR 1206.206 - Availability for copying.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Availability for copying. 1206.206 Section 1206.206 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.206 Availability for copying. Except as...

  18. 14 CFR 1206.206 - Availability for copying.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Availability for copying. 1206.206 Section 1206.206 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.206 Availability for copying. Except as...

  19. 7 CFR 295.6 - Public inspection and copying.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Public inspection and copying. 295.6 Section 295.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC § 295.6 Public inspection and copying. 5 U.S.C....

  20. 56. Photographic copy of the original construction drawing, 1934, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    56. Photographic copy of the original construction drawing, 1934, by Sverdrup and Parcel, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Bar bill and bending details - Mark Twain Memorial Bridge, Spanning Mississippi River at US Route 36, Hannibal, Marion County, MO

  1. 52. Photocopy of copy of original Officers' Duplex Quarters drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    52. Photocopy of copy of original Officers' Duplex Quarters drawing by Copeland, 7 April 1932 (Original in possession of Veterans Administration, Wichita, Kansas, copy at Ablah Library, Wichita State University). Heating - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

  2. COPI is essential for Golgi cisternal maturation and dynamics

    PubMed Central

    Ishii, Midori; Suda, Yasuyuki

    2016-01-01

    ABSTRACT Proteins synthesized in the endoplasmic reticulum (ER) are transported to the Golgi and then sorted to their destinations. For their passage through the Golgi, one widely accepted mechanism is cisternal maturation. Cisternal maturation is fulfilled by the retrograde transport of Golgi-resident proteins from later to earlier cisternae, and candidate carriers for this retrograde transport are coat protein complex I (COPI)-coated vesicles. We examined the COPI function in cisternal maturation directly by 4D observation of the transmembrane Golgi-resident proteins in living yeast cells. COPI temperature-sensitive mutants and induced degradation of COPI proteins were used to knockdown COPI function. For both methods, inactivation of COPI subunits Ret1 and Sec21 markedly impaired the transition from cis to medial and to trans cisternae. Furthermore, the movement of cisternae within the cytoplasm was severely restricted when COPI subunits were depleted. Our results demonstrate the essential roles of COPI proteins in retrograde trafficking of the Golgi-resident proteins and dynamics of the Golgi cisternae. PMID:27445311

  3. 48. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    48. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. 671 FT. SPAN, JOINTS L9 TO L12 - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  4. 55. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    55. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. 671 FT. SPAN, JOINTS U17 TO U20 - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  5. 54. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    54. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. 671 FT. SPAN, JOINTS U13 TO U16 - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  6. 47. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    47. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. 671 FT. SPAN, JOINTS L5 TO L8 - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  7. 46. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. 671 FT. SPAN, JOINTS L1 TO L4 - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  8. 52. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    52. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. 671 FT. SPAN, JOINTS U5 TO U8 - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  9. 49. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    49. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. 671 FT. SPAN, JOINTS L13 TO L16 - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  10. 53. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    53. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. 671 FT. SPAN, JOINTS U9 TO U12 - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  11. 50. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    50. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. 671 FT. SPAN, JOINTS L17 TO L20 - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  12. 29 CFR 2570.51 - Public inspection and copies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Public inspection and copies. 2570.51 Section 2570.51 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... Prohibited Transaction Exemption Applications § 2570.51 Public inspection and copies. (a) The...

  13. 51. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    51. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. 671 FT. SPAN, JOINTS L0, U2 TO U4, PORTAL AT U2 - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  14. 29 CFR 2570.51 - Public inspection and copies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Public inspection and copies. 2570.51 Section 2570.51 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... Prohibited Transaction Exemption Applications § 2570.51 Public inspection and copies. (a) The...

  15. 51. Photocopy of copy of original Officers' Duplex Quarters drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    51. Photocopy of copy of original Officers' Duplex Quarters drawing by B.S. Elliott, 7 April 1932 (original in possession of Veterans Administration, Wichita, Kansas, copy at Ablah Library, Wichita State University). Plumbing - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

  16. 40 CFR 716.30 - Submission of copies of studies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Submission of copies of studies. 716.30 Section 716.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... studies. (a)(1) Except as provided in §§ 716.5, 716.20, and 716.50, persons must send to EPA copies of...

  17. 40 CFR 716.30 - Submission of copies of studies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Submission of copies of studies. 716.30 Section 716.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... studies. (a)(1) Except as provided in §§ 716.5, 716.20, and 716.50, persons must send to EPA copies of...

  18. 36 CFR 1254.64 - Will NARA certify copies?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Will NARA certify copies? 1254.64 Section 1254.64 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS AND DONATED HISTORICAL MATERIALS Copying...

  19. 36 CFR 1254.60 - What are NARA's copying services?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false What are NARA's copying services? 1254.60 Section 1254.60 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS AND DONATED HISTORICAL MATERIALS Copying...

  20. 37. Photographic copy of the original construction drawing, 1924, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. Photographic copy of the original construction drawing, 1924, by Kansas City Structural Steel Company, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Details of 200' span - Van Buren Bridge, Spanning Current River at US Route 60, Van Buren, Carter County, MO

  1. 29. Photographic copy of the original construction drawing, 1924, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. Photographic copy of the original construction drawing, 1924, by Missouri State Highway Department, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. General elevation and plan - Van Buren Bridge, Spanning Current River at US Route 60, Van Buren, Carter County, MO

  2. 38. Photographic copy of the original construction drawing, 1924, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. Photographic copy of the original construction drawing, 1924, by Kansas City Structural Steel Company, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Details of 200' span - Van Buren Bridge, Spanning Current River at US Route 60, Van Buren, Carter County, MO

  3. 32. Photographic copy of the original construction drawing, 1924, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. Photographic copy of the original construction drawing, 1924, by Missouri State Highway Department, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Details of intermediate bends and bent 14 - Van Buren Bridge, Spanning Current River at US Route 60, Van Buren, Carter County, MO

  4. 30. Photographic copy of the original construction drawing, 1924, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. Photographic copy of the original construction drawing, 1924, by Missouri State Highway Department, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Details of pier 2 and 3 - Van Buren Bridge, Spanning Current River at US Route 60, Van Buren, Carter County, MO

  5. 35. Photographic copy of the original construction drawing, 1924, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. Photographic copy of the original construction drawing, 1924, by Kansas City Structural Steel Company, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Details of 120' span - Van Buren Bridge, Spanning Current River at US Route 60, Van Buren, Carter County, MO

  6. 39. Photographic copy of the original construction drawing, 1924, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. Photographic copy of the original construction drawing, 1924, by Kansas City Structural Steel Company, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Details of 80' span - Van Buren Bridge, Spanning Current River at US Route 60, Van Buren, Carter County, MO

  7. 36. Photographic copy of the original construction drawing, 1924, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. Photographic copy of the original construction drawing, 1924, by Kansas City Structural Steel Company, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Beams and laterals - Van Buren Bridge, Spanning Current River at US Route 60, Van Buren, Carter County, MO

  8. 33. Photographic copy of the original construction drawing, 1925, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. Photographic copy of the original construction drawing, 1925, by Missouri State Highway Department, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Details of abutment no. 1 (revised) - Van Buren Bridge, Spanning Current River at US Route 60, Van Buren, Carter County, MO

  9. 31. Photographic copy of the original construction drawing, 1924, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. Photographic copy of the original construction drawing, 1924, by Missouri State Highway Department, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Details of pier 9 and abutment 1 - Van Buren Bridge, Spanning Current River at US Route 60, Van Buren, Carter County, MO

  10. 34. Photographic copy of the original construction drawing, 1924, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. Photographic copy of the original construction drawing, 1924, by Kansas City Structural Steel Company, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Plans and elevations - Van Buren Bridge, Spanning Current River at US Route 60, Van Buren, Carter County, MO

  11. 36 CFR 404.5 - Inspection and copying.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Inspection and copying. 404.5 Section 404.5 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION PROCEDURES AND GUIDELINES FOR COMPLIANCE WITH THE FREEDOM OF INFORMATION ACT § 404.5 Inspection and copying. When a...

  12. 36 CFR 404.5 - Inspection and copying.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Inspection and copying. 404.5 Section 404.5 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION PROCEDURES AND GUIDELINES FOR COMPLIANCE WITH THE FREEDOM OF INFORMATION ACT § 404.5 Inspection and copying. When a...

  13. 36 CFR 404.5 - Inspection and copying.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Inspection and copying. 404.5 Section 404.5 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION PROCEDURES AND GUIDELINES FOR COMPLIANCE WITH THE FREEDOM OF INFORMATION ACT § 404.5 Inspection and copying. When a...

  14. 36 CFR 404.5 - Inspection and copying.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Inspection and copying. 404.5 Section 404.5 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION PROCEDURES AND GUIDELINES FOR COMPLIANCE WITH THE FREEDOM OF INFORMATION ACT § 404.5 Inspection and copying. When a...

  15. 36 CFR 404.5 - Inspection and copying.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Inspection and copying. 404.5 Section 404.5 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION PROCEDURES AND GUIDELINES FOR COMPLIANCE WITH THE FREEDOM OF INFORMATION ACT § 404.5 Inspection and copying. When a...

  16. 13. Photographic copy of the original construction drawing, dated August ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photographic copy of the original construction drawing, dated August 1914, from blueprint copy in possession of Utah County Engineering office, Provo, Utah. JORDAN RIVER BRIDGE ON NORTH BOUNDARY, SECTION 12T5S, R1W (SIDE AND END VIEWS) - Jordan Narrows Bridge, Crossing Jordan River at 9600 North, Lehi, Utah County, UT

  17. 6. PHOTOGRAPHIC COPY OF ORIGINAL CONSTRUCTION DRAWING, DATED MAY 15, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. PHOTOGRAPHIC COPY OF ORIGINAL CONSTRUCTION DRAWING, DATED MAY 15, 1919, 7TH CAVALRY CANTONMENT POST EXCHANGE, WAR DEPARTMENT, CONSTRUCTION DIVISION, PLAN No. 357, COPY ON FILE IN THE ENVIRONMENTAL MANAGEMENT OFFICE, FORT BLISS - Fort Bliss, 7th Cavalry Buildings, U.S. Army Air Defence Artillery Center & Fort Bliss, El Paso, El Paso County, TX

  18. 18. Photocopy of copy of drawing of boiler plant and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Photocopy of copy of drawing of boiler plant and shops building, dated June 15, 1944. Copy of drawing stored at 436 Civil Engineer Squadron, Design Management Element Cece, 600 8th Street, Dover AFB, DE - Dover Air Force Base, Hangar No. 1301, Dover, Kent County, DE

  19. 4. PHOTOGRAPHIC COPY OF ORIGINAL CONSTRUCTION DRAWING, DATED MAY 13, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. PHOTOGRAPHIC COPY OF ORIGINAL CONSTRUCTION DRAWING, DATED MAY 13, 1919, DETACHMENT BARRACK WITHOUT MESS, WAR DEPARTMENT, CONSTRUCTION DIVISION, PLAN # 353, COPY ON FILE IN THE ENVIRONMENTAL MANAGEMENT OFFICE, FORT BLISS - Fort Bliss, 7th Cavalry Buildings, U.S. Army Air Defence Artillery Center & Fort Bliss, El Paso, El Paso County, TX

  20. 8. PHOTOGRAPHIC COPY OF AERIAL PHOTOGRAPH, DATED CA. 19201925, FORT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. PHOTOGRAPHIC COPY OF AERIAL PHOTOGRAPH, DATED CA. 1920-1925, FORT BLISS, ARROW POINTS TO 7TH CAVALRY CANTONMENT, COPY ON FILE IN THE ENVIRONMENTAL MANAGEMENT OFFICE, FORT BLISS - Fort Bliss, 7th Cavalry Buildings, U.S. Army Air Defence Artillery Center & Fort Bliss, El Paso, El Paso County, TX

  1. 5. PHOTOGRAPHIC COPY OF ORIGINAL CONSTRUCTION DRAWING, DATED JUNE 14, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. PHOTOGRAPHIC COPY OF ORIGINAL CONSTRUCTION DRAWING, DATED JUNE 14, 1919, 7TH CAVALRY CANTONMENT MESS BUILDING, WAR DEPARTMENT, CONSTRUCTION DIVISION, PLAN No. 316A, COPY ON FILE IN THE ENVIRONMENTAL MANAGEMENT OFFICE, FORT BLISS - Fort Bliss, 7th Cavalry Buildings, U.S. Army Air Defence Artillery Center & Fort Bliss, El Paso, El Paso County, TX

  2. 17. Photocopy of copy of drawing of Hangar 1301, dated ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Photocopy of copy of drawing of Hangar 1301, dated June 15, 1944. Copy of drawing stored at 436 Civil Engineer Squadron, Design Management Element Cece, 600 8th Street, Dover Air Force Base, DE - Dover Air Force Base, Hangar No. 1301, Dover, Kent County, DE

  3. Photo copy of historic photograph, 1944. BUILDING 652, LOOKING SOUTH. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photo copy of historic photograph, 1944. BUILDING 652, LOOKING SOUTH. OCT. 14, 1944. File no. 141. Copy print on file at Library, Corps of Engineers, New England Division, Waltham, Massachusetts - Watertown Arsenal, Building No. 652, Arsenal Street, Watertown, Middlesex County, MA

  4. 48 CFR 6302.25 - Copies of papers (Rule 25).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Copies of papers (Rule 25). 6302.25 Section 6302.25 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION BOARD OF CONTRACT APPEALS RULES OF PROCEDURE 6302.25 Copies of papers (Rule 25). When books, records, papers,...

  5. 6. Photo copy of photograph, (original owned by Mary Gaudineer, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photo copy of photograph, (original owned by Mary Gaudineer, Beckley, WV, copy at National Forest Office, Elkins, WV), Don Gaudineer, 1934. CONSTRUCTION OF FERNOW EXPERIMENTAL FOREST BUNKHOUSE AND GARAGE. (see also historic photograph WV-237-13) - Parsons Nursery, Fernow Experimental Forest Residence, South side of U.S. Route 219, Parsons, Tucker County, WV

  6. Vocal copying of individually distinctive signature whistles in bottlenose dolphins.

    PubMed

    King, Stephanie L; Sayigh, Laela S; Wells, Randall S; Fellner, Wendi; Janik, Vincent M

    2013-04-22

    Vocal learning is relatively common in birds but less so in mammals. Sexual selection and individual or group recognition have been identified as major forces in its evolution. While important in the development of vocal displays, vocal learning also allows signal copying in social interactions. Such copying can function in addressing or labelling selected conspecifics. Most examples of addressing in non-humans come from bird song, where matching occurs in an aggressive context. However, in other animals, addressing with learned signals is very much an affiliative signal. We studied the function of vocal copying in a mammal that shows vocal learning as well as complex cognitive and social behaviour, the bottlenose dolphin (Tursiops truncatus). Copying occurred almost exclusively between close associates such as mother-calf pairs and male alliances during separation and was not followed by aggression. All copies were clearly recognizable as such because copiers consistently modified some acoustic parameters of a signal when copying it. We found no evidence for the use of copying in aggression or deception. This use of vocal copying is similar to its use in human language, where the maintenance of social bonds appears to be more important than the immediate defence of resources.

  7. An Evidence-Informed Picture of Course-Related Copying

    ERIC Educational Resources Information Center

    Graham, Rumi

    2016-01-01

    Recent changes in Canadian copyright law have prompted Canada's educational institutions to reexamine their need for a blanket copying license. Users' rights under the amended Copyright Act now include fair dealing for purposes of education, and the Supreme Court has established that copying short excerpts for classroom use can qualify as fair…

  8. 48. Photocopy of copy of original Officers' Duplex Quarters drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    48. Photocopy of copy of original Officers' Duplex Quarters drawing by Turner, 7 April 1932 (original in possession of Veterans Administration, Wichita, Kansas, copy at Ablah Library, Wichita State University). Attic and roof, basement, first floor, and second floor plans - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

  9. 50. Photocopy of copy of original Officers' Duplex Quarters drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    50. Photocopy of copy of original Officers' Duplex Quarters drawing by Turner, 7 April 1932 (original in possession of Veterans Administration, Wichita, Kansas, copy at Ablah Library, Wichita State University. Detail of front entrance and of gable dormer - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

  10. 49. Photocopy of copy of original Officers' Duplex Quarters drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    49. Photocopy of copy of original Officers' Duplex Quarters drawing by Turner, 7 April 1932 (original in possession of Veterans Administration, Wichita, Kansas, copy at Ablah Library, Wichita State University). Front, rear, and side elevations, and cross-section - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

  11. 31 CFR 1.4 - Public inspection and copying.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Public inspection and copying. 1.4 Section 1.4 Money and Finance: Treasury Office of the Secretary of the Treasury DISCLOSURE OF RECORDS Freedom of Information Act § 1.4 Public inspection and copying. (a) In general. Subject to the application of the exemptions and exclusions...

  12. 37 CFR 1.95 - Copies of exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National Processing Provisions Models, Exhibits, Specimens § 1.95 Copies of exhibits. Copies of models or other physical exhibits will not ordinarily be furnished by the Office, and any model or exhibit in an application or patent shall not be taken from...

  13. 56. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    56. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. 671 FT. SPAN, SPECIAL FEATURES FOR SPAN 1 - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  14. 61. Photographic copy of the original construction drawing, 19356, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    61. Photographic copy of the original construction drawing, 1935-6, by Sverdrup and Parcel, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Revisions in back wall of abutment B17 - Mark Twain Memorial Bridge, Spanning Mississippi River at US Route 36, Hannibal, Marion County, MO

  15. 5 CFR 9301.16 - Requests for copies of records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Requests for copies of records. 9301.16 Section 9301.16 Administrative Personnel SPECIAL INSPECTOR GENERAL FOR AFGHANISTAN RECONSTRUCTION DISCLOSURE OF RECORDS AND INFORMATION Privacy Act § 9301.16 Requests for copies of records. Rules...

  16. 5 CFR 9301.16 - Requests for copies of records.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Requests for copies of records. 9301.16 Section 9301.16 Administrative Personnel SPECIAL INSPECTOR GENERAL FOR AFGHANISTAN RECONSTRUCTION DISCLOSURE OF RECORDS AND INFORMATION Privacy Act § 9301.16 Requests for copies of records. Rules...

  17. 48 CFR 6302.25 - Copies of papers (Rule 25).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Copies of papers (Rule 25). 6302.25 Section 6302.25 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION BOARD OF CONTRACT APPEALS RULES OF PROCEDURE 6302.25 Copies of papers (Rule 25). When books, records, papers,...

  18. 9. Photographic copy of USRS design drawing, April 1906 (from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Photographic copy of USRS design drawing, April 1906 (from duplicate copy on file at United States Bureau of Reclamation, Denver Service Center, Denver, Colorado). Main canal diversion weir from Salmon River - Salmon Creek Diversion Dam, Salmon Creek, Okanogan, Okanogan County, WA

  19. The Effect of Copying on the Producers of Originals.

    ERIC Educational Resources Information Center

    Johnson, William R.

    Arguing that the seller of creative works--including audio and video productions and computer software--will be affected by the ability of consumers to make high quality copies of these works, this paper examines the theoretical effects of copying on the sellers of originals and speculates about ways to estimate these effects empirically. The…

  20. The Development of Context Sensitivity in Children's Graphic Copying Strategies

    ERIC Educational Resources Information Center

    Vinter, Annie; Marot, Valerie

    2007-01-01

    The authors report on a series of 5 experiments in which 462 5- to 10-year-old children and 109 adults were required to copy geometric figures either with no constraints or following prior exposure to primes consisting of different parsings of the figures. The analysis focused on the graphic strategies adopted by the participants to copy the…

  1. 9. Photo copy of historic photograph, Nov. 4, 1944. Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Photo copy of historic photograph, Nov. 4, 1944. Building 60, INTERIOR, EAST END, LOOKING NORTH AT AIR COMPRESSORS. File No. 75. Copy print on file, Library, U.S. Army Corps of Engineers, New England Division, Waltham, Massachusetts. - Watertown Arsenal, Building No. 60, Arsenal Street, Watertown, Middlesex County, MA

  2. 11. Photo copy of historic photograph, May 1953. Building 60, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photo copy of historic photograph, May 1953. Building 60, INTERIOR, WEST END, LOOKING SOUTHWEST AT NEWLY INSTALLED ERIE CITY IRON WORKS BOILERS AND CONTROL PANEL. File no. 200. Copy print on file, Library, Corps of Engineers, New England Division, Waltham, Massachusetts. - Watertown Arsenal, Building No. 60, Arsenal Street, Watertown, Middlesex County, MA

  3. 10. Photo copy of historic photograph, Nov. 4, 1944. Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Photo copy of historic photograph, Nov. 4, 1944. Building 60, INTERIOR, WEST END, LOOKING SOUTH BETWEEN BANKS OF HEINE BOILERS. File No. 74, Copy print on file, Library, U.S. Army Corps of Engineers, New England Division, Waltham, Massachusetts. - Watertown Arsenal, Building No. 60, Arsenal Street, Watertown, Middlesex County, MA

  4. 35. Photographic copy of original construction drawing, dated May 22, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. Photographic copy of original construction drawing, dated May 22, 1951 (from paper copy at Engineering Flight, Ellsworth Air Force Base, SD). Readiness hangar structural: front elevation bracing details. - Ellsworth Air Force Base, Readiness Hangar, Kenny Road, southeast corner of interstction with G Avenue, Blackhawk, Meade County, SD

  5. 36. Photographic copy of original construction drawing, dated May 22, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. Photographic copy of original construction drawing, dated May 22, 1951 (from paper copy at Engineering Flight, Ellsworth Air Force Base, SD). Readiness hangar structural: rear elevation framing details. - Ellsworth Air Force Base, Readiness Hangar, Kenny Road, southeast corner of interstction with G Avenue, Blackhawk, Meade County, SD

  6. 34. Photographic copy of original construction drawing, dated May 22, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. Photographic copy of original construction drawing, dated May 22, 1951 (from paper copy at Engineering Flight, Ellsworth Air Force Base, SD). Readiness hangar structural: truss braces TB1 to TB4. - Ellsworth Air Force Base, Readiness Hangar, Kenny Road, southeast corner of interstction with G Avenue, Blackhawk, Meade County, SD

  7. 30. Photographic copy of original construction drawing, dated May 22, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. Photographic copy of original construction drawing, dated May 22, 1951 (from paper copy at Engineering Flight, Ellsworth Air Force Base, SD). Readiness hangar structural: buttresses & misc. Details. - Ellsworth Air Force Base, Readiness Hangar, Kenny Road, southeast corner of interstction with G Avenue, Blackhawk, Meade County, SD

  8. 33. Photographic copy of original construction drawing, dated May 22, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. Photographic copy of original construction drawing, dated May 22, 1951 (from paper copy at Engineering Flight, Ellsworth Air Force Base, SD). Readiness hangar structural: details of trusses T2 to T6. - Ellsworth Air Force Base, Readiness Hangar, Kenny Road, southeast corner of interstction with G Avenue, Blackhawk, Meade County, SD

  9. 32. Photographic copy of original construction drawing, dated May 22, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. Photographic copy of original construction drawing, dated May 22, 1951 (from paper copy at Engineering Flight, Ellsworth Air Force Base, SD). Readiness hangar structural: details of trusses T1 & T7. - Ellsworth Air Force Base, Readiness Hangar, Kenny Road, southeast corner of interstction with G Avenue, Blackhawk, Meade County, SD

  10. 31. Photographic copy of original construction drawing, dated May 22, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. Photographic copy of original construction drawing, dated May 22, 1951 (from paper copy at Engineering Flight, Ellsworth Air Force Base, SD). Readiness hangar structural: top chord framing & details. - Ellsworth Air Force Base, Readiness Hangar, Kenny Road, southeast corner of interstction with G Avenue, Blackhawk, Meade County, SD

  11. 10 CFR 205.372 - Filing procedures; number of copies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Filing procedures; number of copies. 205.372 Section 205.372 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Electric Power System... and Reliability, Department of Energy. Copies of all documents also shall be served on: (a)...

  12. 10 CFR 205.372 - Filing procedures; number of copies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Filing procedures; number of copies. 205.372 Section 205.372 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Electric Power System... and Reliability, Department of Energy. Copies of all documents also shall be served on: (a)...

  13. 1. Historic American Buildings Survey Copy photo: Albern Color Research, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Copy photo: Albern Color Research, Inc., Philadelphia, July 1960 COPY OF A PHOTOGRAPH TAKEN ca. 1904 SHOWING PART OF THE ENFIELD, NEW HAMPSHIRE SHAKER COMMUNITY WITH THE GREAT STONE HOUSE IN THE CENTER - Shaker Church Family General Views, State Route 4A, Enfield, Grafton County, NH

  14. 41. Photographic copy of the original construction drawing, 192627, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. Photographic copy of the original construction drawing, 1926-27, by Harrington, Howard, and Ash, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. STRESS SHEET - Cape Girardeau Bridge, Spanning Mississippi River at State Highway 146, Cape Girardeau, Cape Girardeau County, MO

  15. 20. Photographic copy of the original construction drawing, 193031, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Photographic copy of the original construction drawing, 1930-31, by Sverdrup and Parcel, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department, Jefferson City, Missouri. Truss stress diagram, and plans of laterals and sway braces - Gasconade Bridge, Spanning Gasconade River at State Route 100, Gasconade, Gasconade County, MO

  16. 37. Photographic copy of the original construction drawing, 1934, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. Photographic copy of the original construction drawing, 1934, by Sverdrup and Parcel, Consulting Engineers, from microfilm copy at Bridge Division, Missouri Highway and Transportation Department. Stress sheet, continuous span - Mark Twain Memorial Bridge, Spanning Mississippi River at US Route 36, Hannibal, Marion County, MO

  17. 29 CFR 2570.51 - Public inspection and copies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Public inspection and copies. 2570.51 Section 2570.51 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... Transaction Exemption Applications § 2570.51 Public inspection and copies. (a) The administrative record...

  18. 40 CFR 265.53 - Copies of contingency plan.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Copies of contingency plan. 265.53 Section 265.53 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Contingency Plan and Emergency Procedures § 265.53 Copies of contingency plan. A...

  19. 53. Photographic copy of historic photograph, view of north front ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    53. Photographic copy of historic photograph, view of north front corner showing cast-iron fence, 1902 (Portsmouth Naval Shipyard Museum, Portsmouth, VA; copy photo for Marshall W. Butt's Portsmouth Under Four Flags 1752-1970, p. 135) - Portsmouth Naval Hospital, Hospital Building, Rixey Place, bounded by Williamson Drive, Holcomb Road, & The Circle, Portsmouth, Portsmouth, VA

  20. 22 CFR 1429.25 - Number of copies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Number of copies. 1429.25 Section 1429.25 Foreign Relations FOREIGN SERVICE LABOR RELATIONS BOARD; FEDERAL LABOR RELATIONS AUTHORITY; GENERAL... AND GENERAL REQUIREMENTS General Requirements § 1429.25 Number of copies. Unless otherwise provided...

  1. 7 CFR 3601.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Public inspection, copying, and indexing. 3601.2 Section 3601.2 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL AGRICULTURAL STATISTICS SERVICE, DEPARTMENT OF AGRICULTURE PUBLIC INFORMATION § 3601.2 Public inspection, copying,...

  2. 7 CFR 3601.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Public inspection, copying, and indexing. 3601.2 Section 3601.2 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL AGRICULTURAL STATISTICS SERVICE, DEPARTMENT OF AGRICULTURE PUBLIC INFORMATION § 3601.2 Public inspection, copying,...

  3. 7 CFR 3601.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Public inspection, copying, and indexing. 3601.2 Section 3601.2 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL AGRICULTURAL STATISTICS SERVICE, DEPARTMENT OF AGRICULTURE PUBLIC INFORMATION § 3601.2 Public inspection, copying,...

  4. 48 CFR 6302.25 - Copies of papers (Rule 25).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Copies of papers (Rule 25). 6302.25 Section 6302.25 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION BOARD OF CONTRACT APPEALS RULES OF PROCEDURE 6302.25 Copies of papers (Rule 25). When books, records, papers,...

  5. 48 CFR 6302.25 - Copies of papers (Rule 25).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Copies of papers (Rule 25). 6302.25 Section 6302.25 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION BOARD OF CONTRACT APPEALS RULES OF PROCEDURE 6302.25 Copies of papers (Rule 25). When books, records, papers,...

  6. 48 CFR 6302.25 - Copies of papers (Rule 25).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Copies of papers (Rule 25). 6302.25 Section 6302.25 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION BOARD OF CONTRACT APPEALS RULES OF PROCEDURE 6302.25 Copies of papers (Rule 25). When books, records, papers,...

  7. Copy Number Studies in Noisy Samples

    PubMed Central

    Ginsbach, Philip; Chen, Bowang; Jiang, Yanxiang; Engelter, Stefan T.; Grond-Ginsbach, Caspar

    2013-01-01

    System noise was analyzed in 77 Affymetrix 6.0 samples from a previous clinical study of copy number variation (CNV). Twenty-three samples were classified as eligible for CNV detection, 29 samples as ineligible and 25 were classified as being of intermediate quality. New software (“noise-free-cnv”) was developed to visualize the data and reduce system noise. Fresh DNA preparations were more likely to yield eligible samples (p < 0.001). Eligible samples had higher rates of successfully genotyped SNPs (p < 0.001) and lower variance of signal intensities (p < 0.001), yielded fewer CNV findings after Birdview analysis (p < 0.001), and showed a tendency to yield fewer PennCNV calls (p = 0.053). The noise-free-cnv software visualized trend patterns of noise in the signal intensities across the ordered SNPs, including a wave pattern of noise, being co-linear with the banding pattern of metaphase chromosomes, as well as system deviations of individual probe sets (per-SNP noise). Wave noise and per-SNP noise occurred independently and could be separately removed from the samples. We recommend a two-step procedure of CNV validation, including noise reduction and visual inspection of all CNV calls, prior to molecular validation of a selected number of putative CNVs.

  8. Copy number variation in bipolar disorder

    PubMed Central

    Green, EK; Rees, E; Walters, JTR; Smith, K-G; Forty, L; Grozeva, D; Moran, JL; Sklar, P; Ripke, S; Chambert, KD; Genovese, G; McCarroll, SA; Jones, I; Jones, L; Owen, MJ; O’Donovan, MC; Craddock, N; Kirov, G

    2016-01-01

    Large (>100 kb), rare (<1% in the population) copy number variants (CNVs) have been shown to confer risk for schizophrenia (SZ), but the findings for bipolar disorder (BD) are less clear. In a new BD sample from the United Kingdom (n = 2591), we have examined the occurrence of CNVs and compared this with previously reported samples of 6882 SZ and 8842 control subjects. When combined with previous data, we find evidence for a contribution to BD for three SZ-associated CNV loci: duplications at 1q21.1 (P = 0.022), deletions at 3q29 (P = 0.03) and duplications at 16p11.2 (P = 2.3 × 10−4). The latter survives multiple-testing correction for the number of recurrent large CNV loci in the genome. Genes in 20 regions (total of 55 genes) were enriched for rare exonic CNVs among BD cases, but none of these survives correction for multiple testing. Finally, our data provide strong support for the hypothesis of a lesser contribution of very large (>500 kb) CNVs in BD compared with SZ, most notably for deletions >1 Mb (P = 9 × 10−4). PMID:25560756

  9. The double copy: Bremsstrahlung and accelerating black holes

    NASA Astrophysics Data System (ADS)

    Luna, Andrés; Monteiro, Ricardo; Nicholso, Isobel; O'Connell, Donal; White, Chris D.

    2016-06-01

    Advances in our understanding of perturbation theory suggest the existence of a correspondence between classical general relativity and Yang-Mills theory. A concrete example of this correspondence, which is known as the double copy, was recently intro-duced for the case of stationary Kerr-Schild spacetimes. Building on this foundation, we examine the simple time-dependent case of an accelerating, radiating point source. The gravitational solution, which generalises the Schwarzschild solution, includes a non-trivial stress-energy tensor. This stress-energy tensor corresponds to a gauge theoretic current in the double copy. We interpret both of these sources as representing the radiative part of the field. Furthermore, in the simple example of Bremsstrahlung, we determine a scattering amplitude describing the radiation, maintaining the double copy throughout. Our results provide the strongest evidence yet that the classical double copy is directly related to the BCJ double copy for scattering amplitudes.

  10. Regulatory element copy number differences shape primate expression profiles

    PubMed Central

    Iskow, Rebecca C.; Gokcumen, Omer; Abyzov, Alexej; Malukiewicz, Joanna; Zhu, Qihui; Sukumar, Ann T.; Pai, Athma A.; Mills, Ryan E.; Habegger, Lukas; Cusanovich, Darren A.; Rubel, Meagan A.; Perry, George H.; Gerstein, Mark; Stone, Anne C.; Gilad, Yoav; Lee, Charles

    2012-01-01

    Gene expression differences are shaped by selective pressures and contribute to phenotypic differences between species. We identified 964 copy number differences (CNDs) of conserved sequences across three primate species and examined their potential effects on gene expression profiles. Samples with copy number different genes had significantly different expression than samples with neutral copy number. Genes encoding regulatory molecules differed in copy number and were associated with significant expression differences. Additionally, we identified 127 CNDs that were processed pseudogenes and some of which were expressed. Furthermore, there were copy number-different regulatory regions such as ultraconserved elements and long intergenic noncoding RNAs with the potential to affect expression. We postulate that CNDs of these conserved sequences fine-tune developmental pathways by altering the levels of RNA. PMID:22797897

  11. Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive

    PubMed Central

    Mishra, Sweta

    2016-01-01

    Chromosomal copy number changes are frequently associated with harmful consequences and are thought of as an underlying mechanism for the development of diseases. However, changes in copy number are observed during development and occur during normal biological processes. In this review, we highlight the causes and consequences of copy number changes in normal physiologic processes as well as cover their associations with cancer and acquired drug resistance. We discuss the permanent and transient nature of copy number gains and relate these observations to a new mechanism driving transient site-specific copy gains (TSSGs). Finally, we discuss implications of TSSGs in generating intratumoral heterogeneity and tumor evolution and how TSSGs can influence the therapeutic response in cancer. PMID:26755558

  12. The Differential Effects of Two Self-Managed Math Instruction Procedures: Cover, Copy, and Compare versus Copy, Cover, and Compare

    ERIC Educational Resources Information Center

    Grafman, Joel M.; Cates, Gary L.

    2010-01-01

    This study compared the fluency and error rates produced when using the Cover, Copy, and Compare (CCC) and a modified CCC procedure (MCCC) called Copy, Cover, and Compare to complete subtraction math problems. Two second-grade classrooms consisting of 47 total students participated in the study. The following items were administered to…

  13. Eclipse period of R1 plasmids during downshift from elevated copy number: Nonrandom selection of copies for replication.

    PubMed

    Olsson, Jan A; Berg, Otto; Nordström, Kurt; Dasgupta, Santanu

    2012-03-01

    The classical Meselson-Stahl density-shift method was used to study replication of pOU71, a runaway-replication derivative of plasmid R1 in Escherichia coli. The miniplasmid maintained the normal low copy number of R1 during steady growth at 30°C, but as growth temperatures were raised above 34°C, the copy number of the plasmid increased to higher levels, and at 42°C, it replicated without control in a runaway replication mode with lethal consequences for the host. The eclipse periods (minimum time between successive replication of the same DNA) of the plasmid shortened with rising copy numbers at increasing growth temperatures (Olsson et al., 2003). In this work, eclipse periods were measured during downshifts in copy number of pOU71 after it had replicated at 39 and 42°C, resulting in 7- and 50-fold higher than normal plasmid copy number per cell, respectively. Eclipse periods for plasmid replication, measured during copy number downshift, suggested that plasmid R1, normally selected randomly for replication, showed a bias such that a newly replicated DNA had a higher probability of replication compared to the bulk of the R1 population. However, even the unexpected nonrandom replication followed the copy number kinetics such that every generation, the plasmids underwent the normal inherited number of replication, n, independent of the actual number of plasmid copies in a newborn cell.

  14. Copy number analysis of the low-copy repeats at the primate NPHP1 locus by array comparative genomic hybridization.

    PubMed

    Yuan, Bo; Liu, Pengfei; Rogers, Jeffrey; Lupski, James R

    2016-06-01

    Array comparative genomic hybridization (aCGH) has been widely used to detect copy number variants (CNVs) in both research and clinical settings. A customizable aCGH platform may greatly facilitate copy number analyses in genomic regions with higher-order complexity, such as low-copy repeats (LCRs). Here we present the aCGH analyses focusing on the 45 kb LCRs [1] at the NPHP1 region with diverse copy numbers in humans. Also, the interspecies aCGH analysis comparing human and nonhuman primates revealed dynamic copy number transitions of the human 45 kb LCR orthologues during primate evolution and therefore shed light on the origin of complexity at this locus. The original aCGH data are available at GEO under GSE73962. PMID:27222811

  15. Converting hard copy documents for electronic dissemination

    SciTech Connect

    Hoffman, F.

    1994-12-31

    Since the advent of computer systems, the goal of a paperless office, and even a paperless society, has been pursued. While the normal paper flow in an organization is far from totally automated, particularly for items requiring signatures or authorizations, electronic information dissemination is becoming an almost simple task. The reasons for providing on-line documents are many and include faster and easier access for everyone, elimination of printing costs, reduction of wasted shelf and desk space, and the security of having a centrally-located, always up-to-date document. New computer software even provides the user with the ability to annotate documents and to have bookmarks so that the old scribbled-in and dog-eared manual can be replaced without loosing this `customizability`. Moreover, new hypermedia capabilities mean that documents can be read in a non-linear fashion and can include color figures and photographs, audio, and even animation sequences, capabilities which exceed those of paper. The proliferation of network-based information servers, coupled with the growth of the Internet, has enticed academic, governmental, and even commercial organizations to provide increasing numbers of documents and data bases in electronic form via the network, not just to internal staff, but to the public as well. Much of this information, which includes everything from mundane company procedures to spiffy marketing brochures, was previously published only in hard copy. Converting existing documents to electronic form and producing only electronic versions of new documents poses some interesting challenges to the maintainer or author.

  16. Copy Number Variation in the Horse Genome

    PubMed Central

    Ghosh, Sharmila; Qu, Zhipeng; Das, Pranab J.; Fang, Erica; Juras, Rytis; Cothran, E. Gus; McDonell, Sue; Kenney, Daniel G.; Lear, Teri L.; Adelson, David L.; Chowdhary, Bhanu P.; Raudsepp, Terje

    2014-01-01

    We constructed a 400K WG tiling oligoarray for the horse and applied it for the discovery of copy number variations (CNVs) in 38 normal horses of 16 diverse breeds, and the Przewalski horse. Probes on the array represented 18,763 autosomal and X-linked genes, and intergenic, sub-telomeric and chrY sequences. We identified 258 CNV regions (CNVRs) across all autosomes, chrX and chrUn, but not in chrY. CNVs comprised 1.3% of the horse genome with chr12 being most enriched. American Miniature horses had the highest and American Quarter Horses the lowest number of CNVs in relation to Thoroughbred reference. The Przewalski horse was similar to native ponies and draft breeds. The majority of CNVRs involved genes, while 20% were located in intergenic regions. Similar to previous studies in horses and other mammals, molecular functions of CNV-associated genes were predominantly in sensory perception, immunity and reproduction. The findings were integrated with previous studies to generate a composite genome-wide dataset of 1476 CNVRs. Of these, 301 CNVRs were shared between studies, while 1174 were novel and require further validation. Integrated data revealed that to date, 41 out of over 400 breeds of the domestic horse have been analyzed for CNVs, of which 11 new breeds were added in this study. Finally, the composite CNV dataset was applied in a pilot study for the discovery of CNVs in 6 horses with XY disorders of sexual development. A homozygous deletion involving AKR1C gene cluster in chr29 in two affected horses was considered possibly causative because of the known role of AKR1C genes in testicular androgen synthesis and sexual development. While the findings improve and integrate the knowledge of CNVs in horses, they also show that for effective discovery of variants of biomedical importance, more breeds and individuals need to be analyzed using comparable methodological approaches. PMID:25340504

  17. Copy number variation in schizophrenia in Sweden.

    PubMed

    Szatkiewicz, J P; O'Dushlaine, C; Chen, G; Chambert, K; Moran, J L; Neale, B M; Fromer, M; Ruderfer, D; Akterin, S; Bergen, S E; Kähler, A; Magnusson, P K E; Kim, Y; Crowley, J J; Rees, E; Kirov, G; O'Donovan, M C; Owen, M J; Walters, J; Scolnick, E; Sklar, P; Purcell, S; Hultman, C M; McCarroll, S A; Sullivan, P F

    2014-07-01

    Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy number variations (CNVs) in SCZ cases and identified multiple rare recurrent CNVs that increase risk of SCZ although with incomplete penetrance and pleiotropic effects. Identification of additional recurrent CNVs and biological pathways enriched for SCZ CNVs requires greater sample sizes. We conducted a genome-wide survey for CNVs associated with SCZ using a Swedish national sample (4719 cases and 5917 controls). High-confidence CNV calls were generated using genotyping array intensity data, and their effect on risk of SCZ was measured. Our data confirm increased burden of large, rare CNVs in SCZ cases as well as significant associations for recurrent 16p11.2 duplications, 22q11.2 deletions and 3q29 deletions. We report a novel association for 17q12 duplications (odds ratio=4.16, P=0.018), previously associated with autism and mental retardation but not SCZ. Intriguingly, gene set association analyses implicate biological pathways previously associated with SCZ through common variation and exome sequencing (calcium channel signaling and binding partners of the fragile X mental retardation protein). We found significantly increased burden of the largest CNVs (>500 kb) in genes present in the postsynaptic density, in genomic regions implicated via SCZ genome-wide association studies and in gene products localized to mitochondria and cytoplasm. Our findings suggest that multiple lines of genomic inquiry--genome-wide screens for CNVs, common variation and exonic variation--are converging on similar sets of pathways and/or genes. PMID:24776740

  18. Copy Number Profiling of Brazilian Astrocytomas

    PubMed Central

    Bidinotto, Lucas Tadeu; Torrieri, Raul; Mackay, Alan; Almeida, Gisele Caravina; Viana-Pereira, Marta; Cruvinel-Carloni, Adriana; Spina, Maria Luisa; Campanella, Nathalia Cristina; Pereira de Menezes, Weder; Clara, Carlos Afonso; Becker, Aline Paixão; Jones, Chris; Reis, Rui Manuel

    2016-01-01

    Copy number alterations (CNA) are one of the driving mechanisms of glioma tumorigenesis, and are currently used as important biomarkers in the routine setting. Therefore, we performed CNA profiling of 65 astrocytomas of distinct malignant grades (WHO grade I–IV) of Brazilian origin, using array-CGH and microsatellite instability analysis (MSI), and investigated their correlation with TERT and IDH1 mutational status and clinico-pathological features. Furthermore, in silico analysis using the Oncomine database was performed to validate our findings and extend the findings to gene expression level. We found that the number of genomic alterations increases in accordance with glioma grade. In glioblastomas (GBM), the most common alterations were gene amplifications (PDGFRA, KIT, KDR, EGFR, and MET) and deletions (CDKN2A and PTEN). Log-rank analysis correlated EGFR amplification and/or chr7 gain with better survival of the patients. MSI was observed in 11% of GBMs. A total of 69% of GBMs presented TERT mutation, whereas IDH1 mutation was most frequent in diffuse (85.7%) and anaplastic (100%) astrocytomas. The combination of 1p19q deletion and TERT and IDH1 mutational status separated tumor groups that showed distinct age of diagnosis and outcome. In silico validation pointed to less explored genes that may be worthy of future investigation, such as CDK2, DMRTA1, and MTAP. Herein, using an extensive integrated analysis, we indicated potentially important genes, not extensively studied in gliomas, that could be further explored to assess their biological and clinical impact in astrocytomas. PMID:27172220

  19. Copy number variation in the horse genome.

    PubMed

    Ghosh, Sharmila; Qu, Zhipeng; Das, Pranab J; Fang, Erica; Juras, Rytis; Cothran, E Gus; McDonell, Sue; Kenney, Daniel G; Lear, Teri L; Adelson, David L; Chowdhary, Bhanu P; Raudsepp, Terje

    2014-10-01

    We constructed a 400K WG tiling oligoarray for the horse and applied it for the discovery of copy number variations (CNVs) in 38 normal horses of 16 diverse breeds, and the Przewalski horse. Probes on the array represented 18,763 autosomal and X-linked genes, and intergenic, sub-telomeric and chrY sequences. We identified 258 CNV regions (CNVRs) across all autosomes, chrX and chrUn, but not in chrY. CNVs comprised 1.3% of the horse genome with chr12 being most enriched. American Miniature horses had the highest and American Quarter Horses the lowest number of CNVs in relation to Thoroughbred reference. The Przewalski horse was similar to native ponies and draft breeds. The majority of CNVRs involved genes, while 20% were located in intergenic regions. Similar to previous studies in horses and other mammals, molecular functions of CNV-associated genes were predominantly in sensory perception, immunity and reproduction. The findings were integrated with previous studies to generate a composite genome-wide dataset of 1476 CNVRs. Of these, 301 CNVRs were shared between studies, while 1174 were novel and require further validation. Integrated data revealed that to date, 41 out of over 400 breeds of the domestic horse have been analyzed for CNVs, of which 11 new breeds were added in this study. Finally, the composite CNV dataset was applied in a pilot study for the discovery of CNVs in 6 horses with XY disorders of sexual development. A homozygous deletion involving AKR1C gene cluster in chr29 in two affected horses was considered possibly causative because of the known role of AKR1C genes in testicular androgen synthesis and sexual development. While the findings improve and integrate the knowledge of CNVs in horses, they also show that for effective discovery of variants of biomedical importance, more breeds and individuals need to be analyzed using comparable methodological approaches.

  20. Plasmid Copy Number Determination by Quantitative Polymerase Chain Reaction.

    PubMed

    Anindyajati; Artarini, A Anita; Riani, Catur; Retnoningrum, Debbie S

    2016-01-01

    Recombinant therapeutic proteins are biopharmaceutical products that develop rapidly for years. Recombinant protein production in certain hosts requires vector expression harboring the gene encoding the corresponding protein. Escherichia coli is the prokaryote organism mostly used in recombinant protein production, commonly using a plasmid as the expression vector. Recombinant protein production is affected by plasmid copy number harboring the encoded gene, hence the determination of plasmid copy number also plays an important role in establishing a recombinant protein production system. On the industrial scale, a low copy number of plasmids are more suitable due to their better stability. In the previous study we constructed pCAD, a plasmid derived from the low copy number pBR322 plasmid. This study was aimed to confirm pCAD's copy number by quantitative polymerase chain reaction (qPCR). Plasmid copy number was determined by comparing the quantification signal from the plasmid to those from the chromosome. Copy number was then calculated by using a known copy number plasmid as a standard. Two pairs of primers, called tdk and ori, were designed for targeting a single gene tdk in the chromosome and a conserved domain in the plasmid's ori, respectively. Primer quality was analyzed in silico using PrimerSelect DNASTAR and PraTo software prior to in vitro evaluation on primer specificity and efficiency as well as optimization of qPCR conditions. Plasmid copy number determination was conducted on E. coli lysates harboring each plasmid, with the number of cells ranging from 10(2)-10(5) cells/μL. Cells were lysed by incubation at 95ºC for 10 minutes, followed by immediate freezing at -4°C. pBR322 plasmid with the copy number of ~19 copies/cell was used as the standard, while pJExpress414-sod plasmid possessing the high copy number pUC ori was also determined to test the method being used. In silico analysis based on primer-primer and primer-template interactions showed

  1. Dissecting the Role of COPI Complexes in Influenza Virus Infection

    PubMed Central

    Sun, Eileen; He, Jiang

    2013-01-01

    As an obligate pathogen, influenza virus requires host cell factors and compartments to mediate productive infection and to produce infectious progeny virus. Recently, several small interfering RNA (siRNA) knockdown screens revealed influenza virus host dependency proteins, all of which identified at least two subunits of the coat protein I (COPI) complex. COPI proteins oligomerize to form coated vesicles that transport contents between the Golgi apparatus and the endoplasmic reticulum, and they have also been reported to mediate endosomal trafficking. However, it remains unclear which steps in the influenza virus infection cycle rely on the COPI complex. Upon systematic dissection of the influenza virus infection cycle, from entry to progeny virion production, we found that prolonged exposure to COPI complex disruption through siRNA depletion resulted in significant defects in virus internalization and trafficking to late endosomes. Acute inhibition of COPI complex recruitment to the Golgi apparatus with pharmacological compounds failed to recapitulate the same entry defects as observed with the COPI-depleted cells but did result in specific decreases in viral membrane protein expression and assembly, leading to defects in progeny virion production. Taken together, our findings suggest that COPI complexes likely function indirectly in influenza virus entry but play direct roles in viral membrane protein expression and assembly. PMID:23255804

  2. Evaluation of soft copy distribution of diagnostic studies before soft copy interpretation.

    PubMed

    McEnery, Kevin W; Suitor, Charles T; Thompson, Stephen K; Shepard, Jeffrey S; Murphy, William A

    2002-01-01

    To meet the imaging needs of an expanding clinical campus and clinical volume, a web-based image distribution system (Stentor, San Francisco, CA) was implemented before the implementation of soft copy interpretation. This study sought to assess system utilization as a metric of system's capability to meet demand for enterprise image review. Study period included all examinations stored on the system and subsequently viewed from June 1, 2001 to August 8, 2001. Server log files were analyzed for study storage and subsequent study retrieval. A total of 24,887 studies were stored on the server and available for immediate retrieval, and, of these, 12,458 studies (50%) subsequently were reviewed. Modality-specific study review included 65% for computed radiography, 46% for digital radiography, 56% magnetic resonance, 54% for computed tomography, and 18% for ultrasound scan. Enterprise image distribution before the implementation of picture archiving communication system is a viable operational decision and can be implemented successfully before implementation of soft copy interpretation. System utilization indicates a great value in the electronic availability of image studies. PMID:12105702

  3. The classical double copy for Taub-NUT spacetime

    NASA Astrophysics Data System (ADS)

    Luna, Andrés; Monteiro, Ricardo; O'Connell, Donal; White, Chris D.

    2015-11-01

    The double copy is a much-studied relationship between gauge theory and gravity amplitudes. Recently, this was generalised to an infinite family of classical solutions to Einstein's equations, namely stationary Kerr-Schild geometries. In this paper, we extend this to the Taub-NUT solution in gravity, which has a double Kerr-Schild form. The single copy of this solution is a dyon, whose electric and magnetic charges are related to the mass and NUT charge in the gravity theory. Finally, we find hints that the classical double copy extends to curved background geometries.

  4. Rare Copy Number Deletions Predict Individual Variation in Intelligence

    PubMed Central

    Yeo, Ronald A.; Gangestad, Steven W.; Liu, Jingyu; Calhoun, Vince D.; Hutchison, Kent E.

    2011-01-01

    Phenotypic variation in human intellectual functioning shows substantial heritability, as demonstrated by a long history of behavior genetic studies. Many recent molecular genetic studies have attempted to uncover specific genetic variations responsible for this heritability, but identified effects capture little variance and have proven difficult to replicate. The present study, motivated an interest in “mutation load” emerging from evolutionary perspectives, examined the importance of the number of rare (or infrequent) copy number variations (CNVs), and the total number of base pairs included in such deletions, for psychometric intelligence. Genetic data was collected using the Illumina 1MDuoBeadChip Array from a sample of 202 adult individuals with alcohol dependence, and a subset of these (N = 77) had been administered the Wechsler Abbreviated Scale of Intelligence (WASI). After removing CNV outliers, the impact of rare genetic deletions on psychometric intelligence was investigated in 74 individuals. The total length of the rare deletions significantly and negatively predicted intelligence (r = −.30, p = .01). As prior studies have indicated greater heritability in individuals with relatively higher parental socioeconomic status (SES), we also examined the impact of ethnicity (Anglo/White vs. Other), as a proxy measure of SES; these groups did not differ on any genetic variable. This categorical variable significantly moderated the effect of length of deletions on intelligence, with larger effects being noted in the Anglo/White group. Overall, these results suggest that rare deletions (between 5% and 1% population frequency or less) adversely affect intellectual functioning, and that pleotropic effects might partly account for the association of intelligence with health and mental health status. Significant limitations of this research, including issues of generalizability and CNV measurement, are discussed. PMID:21298096

  5. Finding-specific display presets for computed radiography soft-copy reading.

    PubMed

    Andriole, K P; Gould, R G; Webb, W R

    1999-05-01

    Much work has been done to optimize the display of cross-sectional modality imaging examinations for soft-copy reading (i.e., window/level tissue presets, and format presentations such as tile and stack modes, four-on-one, nine-on-one, etc). Less attention has been paid to the display of digital forms of the conventional projection x-ray. The purpose of this study is to assess the utility of providing presets for computed radiography (CR) soft-copy display, based not on the window/level settings, but on processing applied to the image optimized for visualization of specific findings, pathologies, etc (i.e., pneumothorax, tumor, tube location). It is felt that digital display of CR images based on finding-specific processing presets has the potential to: speed reading of digital projection x-ray examinations on soft copy; improve diagnostic efficacy; standardize display across examination type, clinical scenario, important key findings, and significant negatives; facilitate image comparison; and improve confidence in and acceptance of soft-copy reading. Clinical chest images are acquired using an Agfa-Gevaert (Mortsel, Belgium) ADC 70 CR scanner and Fuji (Stamford, CT) 9000 and AC2 CR scanners. Those demonstrating pertinent findings are transferred over the clinical picture archiving and communications system (PACS) network to a research image processing station (Agfa PS5000), where the optimal image-processing settings per finding, pathologic category, etc, are developed in conjunction with a thoracic radiologist, by manipulating the multiscale image contrast amplification (Agfa MUSICA) algorithm parameters. Soft-copy display of images processed with finding-specific settings are compared with the standard default image presentation for 50 cases of each category. Comparison is scored using a 5-point scale with the positive scale denoting the standard presentation is preferred over the finding-specific processing, the negative scale denoting the finding

  6. 11. Photographic copy of microfilm of construction drawing, dated February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photographic copy of microfilm of construction drawing, dated February 1915, in the possession of the Yellowstone County Surveyor, Yellowstone County Courthouse, Billings, Montana. - Duck Creek Bridge, Spanning Yellowstone River on Route 329, Southwest of Billings, Billings, Yellowstone County, MT

  7. 10. Photographic copy of microfilm of construction drawing, dated February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Photographic copy of microfilm of construction drawing, dated February 1915, in the possession of the Yellowstone County Surveyor, Yellowstone County Courthouse, Billings, Montana. - Duck Creek Bridge, Spanning Yellowstone River on Route 329, Southwest of Billings, Billings, Yellowstone County, MT

  8. 16. Photographic copy of drawing, dated September 1924, in possession ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photographic copy of drawing, dated September 1924, in possession of San Carlos Irrigation Project. United States Indian Service, Irrigation. PIMA LATERAL HEADWORKS, RADIAL GATES - San Carlos Irrigation Project, Pima Lateral, Main Canal at Sacaton Dam, Coolidge, Pinal County, AZ

  9. 176. Photographic copy of original construction drawing dated February 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    176. Photographic copy of original construction drawing dated February 10, 1933 (from Record Group 115, Denver Branch of the National Archives, Denver). OWYHEE DAM; LOCATION OF THERMOMETER GROUPS. - Owyhee Dam, Across Owyhee River, Nyssa, Malheur County, OR

  10. 17 CFR 200.52 - Copies of the Canons.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.52 Copies of the Canons. The Canons have been distributed to employees of the Commission. In addition, executive and professional...

  11. 3. COPY OF A PHOTOGRAPH OF THE CATARACT MILLS, NEWBURGH, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. COPY OF A PHOTOGRAPH OF THE CATARACT MILLS, NEWBURGH, OHIO. Date unknown. Photographer: Berni Rich, Score Photographers, September 1986 - Alexander's Grist Mill, Lock 37 on Ohio & Erie Canal, South of Cleveland, Valley View, Cuyahoga County, OH

  12. 5. PHOTOGRAPHIC COPY OF ORIGINAL DRAWINGS, ELECTRIC AIR AND HEATING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. PHOTOGRAPHIC COPY OF ORIGINAL DRAWINGS, ELECTRIC AIR AND HEATING UNIT, PLAN AND ELEVATION - Wyoming Air National Guard Base, Electric, Air & Heating Plant, Cheyenne Airport, Cheyenne, Laramie County, WY

  13. 13. Photo copy of drawing, Feb. 5, 1912. ARRANGEMENT OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photo copy of drawing, Feb. 5, 1912. ARRANGEMENT OF POWER HOUSE EQUIPMENT. Drawing No. 9053. Facilities Engineering, Army Materials Technology Laboratory, Watertown, Massachusetts. - Watertown Arsenal, Building No. 60, Arsenal Street, Watertown, Middlesex County, MA

  14. 15. Power copy of drawing, August 21, 1915. POWER PLANT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Power copy of drawing, August 21, 1915. POWER PLANT EXTENSION, GENERAL PLANS. Drawing No. PA-A-36692, Facilities Engineering, Army Materials Technology Laboratory, Watertown, Massachusetts. - Watertown Arsenal, Building No. 60, Arsenal Street, Watertown, Middlesex County, MA

  15. 12. Photo copy of drawing, Feb. 5, 1912. ARRANGEMENT OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photo copy of drawing, Feb. 5, 1912. ARRANGEMENT OF POWER HOUSE EQUIPMENT. Drawing No. 9053. Facilities Engineering, Army Materials Technology Laboratory, Watertown, Massachusetts. - Watertown Arsenal, Building No. 60, Arsenal Street, Watertown, Middlesex County, MA

  16. 14. Power copy of drawing, August 21, 1915. POWER PLANT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Power copy of drawing, August 21, 1915. POWER PLANT EXTENSION, GENERAL PLANS. Drawing No. 4415, Facilities Engineering, Army Materials Technology Laboratory, Watertown, Massachusetts. - Watertown Arsenal, Building No. 60, Arsenal Street, Watertown, Middlesex County, MA

  17. 1. Historic American Buildings Survey Copied from view of Tucson ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Copied from view of Tucson in 1880 (Apparently taken from 'A' Mountain). Courtesy Harry Drachman. (Leopoldo Carrillo House in Foreground). - Mission San Cosme del Tucson, Menlo Park, Tucson, Pima County, AZ

  18. 30. Photo copy of photograph, (original in Forest Service Office, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. Photo copy of photograph, (original in Forest Service Office, Elkins, WV, 'tractor with cultivator operating'), photographer unknown, ca. 1938. VIEW SOUTHEAST, CULTIVATING SEEDLING TRANSPLANTS. - Parsons Nursery, South side of U.S. Route 219, Parsons, Tucker County, WV

  19. 28. Photo copy of photograph, (original in Forest Service Office, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Photo copy of photograph, (original in Forest Service Office, Elkins, WV), photographer unknown, August 1939. D. A. OLIVER WITH A TRANSPLANT BOARD. - Parsons Nursery, South side of U.S. Route 219, Parsons, Tucker County, WV

  20. 12. Photo copy of drawing, May 5, 1930. PENFIELD REEF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photo copy of drawing, May 5, 1930. PENFIELD REEF L/S MODERNIZATION. Drawing no. NY-1393, U.S. Coast GUard Civil Engineering Unit, Warwick, Rhode Island. - Penfield Reef Lighthouse, Long Island Sound, Bridgeport, Fairfield County, CT

  1. 14. Photo copy of drawing, April 3, 1952, GREEN'S LEDGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photo copy of drawing, April 3, 1952, GREEN'S LEDGE L/S MODERNIZATION. Drawing no. NY 1517, U.S. Coast Guard Civil Engineering Unit, Warwick, Rhode Island. - Green's Ledge Lighthouse, Long Island Sound, Norwalk, Fairfield County, CT

  2. 27. Photographic copy of undated photo; Photographer unknown; Original owned ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. Photographic copy of undated photo; Photographer unknown; Original owned by Waterloo Community Development Board, Waterloo, Iowa; SPLITTING CATTLE CARCASSES WITH RECIPROCATING SAW - Rath Packing Company, Beef Killing Building, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

  3. 7. Photographic copy of Base Basic Layout Plan, dated 12 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of Base Basic Layout Plan, dated 12 February 1945, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. - Selfridge Field, North of North River Road, east of Irwin Road, Mount Clemens, Macomb County, MI

  4. Photographic copy of photograph (circa 1927) (original print in possession ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph (circa 1927) (original print in possession of Brunner and Brunner, Architect and Engineers, Inc., St. Joseph, Missouri) VIEW OF SOUTHEAST CORNER - Old City Auditorium, 404-424 North Fourth Street, Saint Joseph, Buchanan County, MO

  5. 37. Photo copy of map, (original in Forest Service Office, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. Photo copy of map, (original in Forest Service Office, Elkins, WV, 'Blister Rust Survey Map), 1930. PARSONS NURSERY SITE PLAN - Parsons Nursery, South side of U.S. Route 219, Parsons, Tucker County, WV

  6. Photographic copy of architectural drawing (original drawing located at the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of architectural drawing (original drawing located at the Panama Canal Commission Headquarters Building, Department of Engineering Vault, Balboa Heights, Republic of Panama). Longitudinal section. - Quarry Heights, Officers' Quarters, Parkinson Lane, Balboa, Former Panama Canal Zone, CZ

  7. Photographic copy of architectural drawing (original drawing located at the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of architectural drawing (original drawing located at the Panama Canal Commission Headquarters Building, Department of Engineering Vault, Balboa Heights, Republic of Panama). First floor plan. - Quarry Heights, Officers' Quarters, Parkinson Lane, Balboa, Former Panama Canal Zone, CZ

  8. Photographic copy of architectural drawing (original drawing located at the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of architectural drawing (original drawing located at the Panama Canal Commission Headquarters Building, Department of Engineering Vault, Balboa Heights, Republic of Panama). Front elevation. - Quarry Heights, Officers' Quarters, Parkinson Lane, Balboa, Former Panama Canal Zone, CZ

  9. Photographic copy of architectural drawing (original drawing located at the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of architectural drawing (original drawing located at the Panama Canal Commission Headquarters Building, Department of Engineering Vault, Balboa Heights, Republic of Panama). Second floor plan. - Quarry Heights, Officers' Quarters, Parkinson Lane, Balboa, Former Panama Canal Zone, CZ

  10. Photographic copy of architectural drawing (original drawing located at the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of architectural drawing (original drawing located at the Panama Canal Commission Headquarters Building, Department of Engineering Vault, Balboa Heights, Republic of Panama), Right side elevation. - Quarry Heights, Officers' Quarters, Parkinson Lane, Balboa, Former Panama Canal Zone, CZ

  11. Photographic copy of architectural drawing (original drawing located at the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of architectural drawing (original drawing located at the Panama Canal Commission Headquarters Building, Department of Engineering Vault, Balboa Heights, Republic of Panama). Left side elevation. - Quarry Heights, Officers' Quarters, Parkinson Lane, Balboa, Former Panama Canal Zone, CZ

  12. Photographic copy of architectural drawing (original drawing located at the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of architectural drawing (original drawing located at the Panama Canal Commission Headquarters Building, Department of Engineering Vault, Balboa Heights, Republic of Panama). Rear elevation. - Quarry Heights, Officers' Quarters, Parkinson Lane, Balboa, Former Panama Canal Zone, CZ

  13. 1. Historic American Buildings Survey, Adolph Phillip, Photographer (copy of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Adolph Phillip, Photographer (copy of old photo owned by Adolph Phillip) January, 1937 NORTHEAST ELEVATION OF ORIGINAL CHURCH BUILDING (EAST FRONT AND NORTH SIDE). - San Fernando Cathedral, 115 Main Avenue, San Antonio, Bexar County, TX

  14. 64. Photographic copy of historic photo, July 1908 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    64. Photographic copy of historic photo, July 1908 (original print filed in Record Group 115, National Archives, Washington, D.C.). TEAM MOVING TRACK ON UPPER DEER FLAT EMBANKMENT. - Boise Project, Deer Flat Embankments, Lake Lowell, Nampa, Canyon County, ID

  15. 57. Photographic copy of historic photo, May 1908 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    57. Photographic copy of historic photo, May 1908 (original print filed in Record Group 115, National Archives, Washington, D.C.). UPPER DEER FLAT EMBANKMENT; CAMP AND BUILDINGS. - Boise Project, Deer Flat Embankments, Lake Lowell, Nampa, Canyon County, ID

  16. 68. Photographic copy of historic photo, June, 1912 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    68. Photographic copy of historic photo, June, 1912 (original print filed in Record Group 115, National Archives, Washington, D.C.). INLET GATES, DEER FLAT RESERVOIR. - Boise Project, Deer Flat Embankments, Lake Lowell, Nampa, Canyon County, ID

  17. 54. Photographic copy of historic photo, January 16, 1909 (original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    54. Photographic copy of historic photo, January 16, 1909 (original print filed in Record Group 115, National Archives, Washington, D.C.). LOWER DEER FLAT EMBANKMENT. - Boise Project, Deer Flat Embankments, Lake Lowell, Nampa, Canyon County, ID

  18. 113. Photographic copy of historic photo, June 3, 1932 (original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    113. Photographic copy of historic photo, June 3, 1932 (original print filed in Record Group 115, National Archives, Washington, D.C.). MAKING FINAL PARAPET POURS IN OWYHEE DAM. - Owyhee Dam, Across Owyhee River, Nyssa, Malheur County, OR

  19. Photographic copy of photograph (original print in possession of William ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph (original print in possession of William Langer Jewel Bearing Plant, Rolla, North Dakota). FINAL INSPECTION - Turtle Mountain Ordnance Plant, 213 First Street Northwest, Rolla, Rolette County, ND

  20. Photographic copy of photograph (original print in possession of William ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph (original print in possession of William Langer Jewel Bearing Plant, Rolla, North Dakota). OLIVING - Turtle Mountain Ordnance Plant, 213 First Street Northwest, Rolla, Rolette County, ND

  1. Photographic copy of photograph (original print in possession of William ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph (original print in possession of William Langer Jewel Bearing Plant, Rolla, North Dakota). PASTING JEWEL BLANKS, PREPARATION FOR DRILLING. - Turtle Mountain Ordnance Plant, 213 First Street Northwest, Rolla, Rolette County, ND

  2. Photographic copy of photograph (original print in possession of William ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph (original print in possession of William Langer Jewel Bearing Plant, Rolla, North Dakota). LARGE HOLE-OPENING - Turtle Mountain Ordnance Plant, 213 First Street Northwest, Rolla, Rolette County, ND

  3. Photographic copy of photograph (original print in possession of William ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph (original print in possession of William Langer Jewel Bearing Plant, Rolla, North Dakota). DRILLING - Turtle Mountain Ordnance Plant, 213 First Street Northwest, Rolla, Rolette County, ND

  4. Photographic copy of photograph (original print in possession of William ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph (original print in possession of William Langer Jewel Bearing Plant, Rolla, North Dakota). MACHINE SHOP - Turtle Mountain Ordnance Plant, 213 First Street Northwest, Rolla, Rolette County, ND

  5. 8. Historic American Buildings Survey Thos. T. Waterman, Photographer, Copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Thos. T. Waterman, Photographer, Copy of old photo DETAIL OF FRONT - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  6. 2. Historic American Buildings Survey Thos. T. Waterman, Photographer, Copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Thos. T. Waterman, Photographer, Copy of Old Photo GENERAL VIEW - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  7. 3. Historic American Buildings Survey Thos. T. Waterman, Photographer, Copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Thos. T. Waterman, Photographer, Copy of old photo DETAIL OF FRONT - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  8. 6. Historic American Buildings Survey Thos. T. Waterman, Photographer, Copy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey Thos. T. Waterman, Photographer, Copy of Old Photo FRONT ELEVATION - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  9. "Before" Main House, photographic copy of ca. 1834 watercolor by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    "Before" Main House, photographic copy of ca. 1834 watercolor by Thomas U. Walter. Duplicate color view of HABS PA-1248-35 - Andalusia, State Road vicinity (Bensalem Township), Andalusia, Bucks County, PA

  10. Copy number variation and evolution in humans and chimpanzees

    PubMed Central

    Perry, George H.; Yang, Fengtang; Marques-Bonet, Tomas; Murphy, Carly; Fitzgerald, Tomas; Lee, Arthur S.; Hyland, Courtney; Stone, Anne C.; Hurles, Matthew E.; Tyler-Smith, Chris; Eichler, Evan E.; Carter, Nigel P.; Lee, Charles; Redon, Richard

    2008-01-01

    Copy number variants (CNVs) underlie many aspects of human phenotypic diversity and provide the raw material for gene duplication and gene family expansion. However, our understanding of their evolutionary significance remains limited. We performed comparative genomic hybridization on a single human microarray platform to identify CNVs among the genomes of 30 humans and 30 chimpanzees as well as fixed copy number differences between species. We found that human and chimpanzee CNVs occur in orthologous genomic regions far more often than expected by chance and are strongly associated with the presence of highly homologous intrachromosomal segmental duplications. By adapting population genetic analyses for use with copy number data, we identified functional categories of genes that have likely evolved under purifying or positive selection for copy number changes. In particular, duplications and deletions of genes with inflammatory response and cell proliferation functions may have been fixed by positive selection and involved in the adaptive phenotypic differentiation of humans and chimpanzees. PMID:18775914

  11. 19 CFR 133.42 - Infringing copies or phonorecords.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... pursuant to 19 CFR 133.42(e) was (damaged/destroyed/lost) during examination, testing, or other use.” (f... trafficking in counterfeit labels for phonorecords or copies of motion pictures or other audiovisual works...

  12. 34. Photographic copy of original construction plan (Wabasha Street Bridge, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. Photographic copy of original construction plan (Wabasha Street Bridge, Cantilever Span 1888); web details of cantilever arm connecting first span to first pier - Wabasha Street Bridge, Spanning Mississippi River at Wabasha Street, Saint Paul, Ramsey County, MN

  13. Photographic copy of floor plan, undated, Civil Engineers Office, in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of floor plan, undated, Civil Engineers Office, in possession of Selfridge Base Civil Engineers Office, Mt. Clemens, Michigan - Selfridge Field, Building No. 833, West of Mulberry Street north of George Avenue, Mount Clemens, Macomb County, MI

  14. 19. COPY OF ENGRAVING OF 'WROUGHT IRON ARCH TRUSS BRIDGE,' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. COPY OF ENGRAVING OF 'WROUGHT IRON ARCH TRUSS BRIDGE,' PAT. DEC. 10, 1867 BY OHIO BRIDGE COMPANY, CLEVELAND, OHIO. (COURTESY OF OHIO HISTORICAL SOCIETY ARCHIVES, COLUMBUS, OHIO) - Tioronda Bridge, South Avenue spanning Fishkill Creek, Beacon, Dutchess County, NY

  15. PHOTOGRAPHIC COPY OF PHOTOGRAPH (FROM GIFFORD PINCHOT NATIONAL FOREST COLLECTION, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PHOTOGRAPHIC COPY OF PHOTOGRAPH (FROM GIFFORD PINCHOT NATIONAL FOREST COLLECTION, COPYRIGHT COLUMBIA NATIONAL FOREST. PHOTOGRAPHER UNKNOWN, DECEMBER 13, 1935. TROUT CREEK DAM FISHWAY UNDER CONSTRUCTION - Trout Creek Dam, River Mile 1.8 on Trout Creek, Carson, Skamania County, WA

  16. 3. Historic American Buildings Survey (Copy) Nathaniel R. Ewan, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey (Copy) Nathaniel R. Ewan, Photographer November 15, 1937 INTERIOR - STRONG BOX From anniversary booklet printed by Farmers Trust Co. - not copyrighted. - Farmer's Trust Company Bank Building, 21 Mill Street, Mount Holly, Burlington County, NJ

  17. 1. Historic American Buildings Survey COPIED E. W. Russell, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey COPIED - E. W. Russell, Photographer, August 31, 1936 75TH ANNIVERSARY YEARBOOK (NOT COPYRIGHT) - VIEW OF ORIGINAL BUILDING - Spring Hill College, Original Building, Old Shell Road, Spring Hill, Mobile County, AL

  18. 1. Historic American Buildings Survey Copied by Alex Bush, Photographer, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Copied by Alex Bush, Photographer, March 15, 1935 OLD COLLEGE PAMPHLET. NOT COPYRIGHTED. FRONT AND SIDE VIEW S.E. (BEFORE ALTERATION). - Marion Female Seminary, Monroe & Centreville Streets, Marion, Perry County, AL

  19. 11. COPY OF 1970 AERIAL PHOTOGRAPH OF LORING AIR FORCE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. COPY OF 1970 AERIAL PHOTOGRAPH OF LORING AIR FORCE BASE. PHOTOGRAPH LOCATED AT AIR FORCE BASE CONVERSION AGENCY, LORING AIR FORCE BASE, MAINE. - Loring Air Force Base, Airfield, Central portion of base, Limestone, Aroostook County, ME

  20. 1. Historic American Buildings Survey, Copy, Photographer unknown 1900 (a) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Copy, Photographer unknown 1900 (a) Old Photo showing Kilns about 1900 (from original print found at site) - Charcoal Kilns, Valley Road, Pelham, Hampshire County, MA

  1. 15. Photographic copy of the original construction drawing, 1926, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Photographic copy of the original construction drawing, 1926, by Missouri State Highway Department. Details of rocker bearing and fixed pedestal - Doxie Creek Bridge, Spanning Doxie Creek at State Route 5, Forest Green, Chariton County, MO

  2. 17. Photographic copy of the original construction drawing, 1928, by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Photographic copy of the original construction drawing, 1928, by Missouri State Highway Department. Details of rocker bearing and fixed pedestal - Doxie Creek Bridge, Spanning Doxie Creek at State Route 5, Forest Green, Chariton County, MO

  3. 188. Photographic copy of original construction drawing dated October 20, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    188. Photographic copy of original construction drawing dated October 20, 1932 (from Record Group 115, Denver Branch of the National Archives, Denver). TUNNEL NO. 1 CONTROLLING WORKS; OPERATING HOUSE. - Owyhee Dam, Across Owyhee River, Nyssa, Malheur County, OR

  4. 14. Photo copy of photograph (location of original print unknown) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photo copy of photograph (location of original print unknown) c.1932, photographer unknown Historic view of bridge - Bridge at Mouth of Rogue River, Spanning Rogue River on Oregon Coast Highway, Gold Beach, Curry County, OR

  5. 6. Photographic copy of photograph (date unknown, original print in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photographic copy of photograph (date unknown, original print in the possession of the Wisconsin Veterans Museums). COTTAGES, INCLUDING 'J.P. McPHERSON POST NO. 27 CAFE GENEVA'. - Wisconsin Home for Veterans, King, Waupaca County, WI

  6. 7. Historic American Buildings Survey COPY OF UNDATED DETAIL DRAWINGS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey COPY OF UNDATED DETAIL DRAWINGS, UNITED STATES COAST GUARD DISTRICT OFFICE 427 COMMERCIAL STREET, BOSTON, MASSACHUSETTS - Portland Breakwater Lighthouse, Northeast end of Portland Breakwater, Portland Harbor, South Portland, Cumberland County, ME

  7. 6. Historic American Buildings Survey COPY OF UNDATED DRAWING OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey COPY OF UNDATED DRAWING OF ELEVATION, PLANS, AND SECTION, UNITED STATES COAST GUARD DISTRICT OFFICE 427 COMMERCIAL STREET, BOSTON, MASSACHUSETTS - Portland Breakwater Lighthouse, Northeast end of Portland Breakwater, Portland Harbor, South Portland, Cumberland County, ME

  8. Female copying increases the variance in male mating success.

    PubMed

    Wade, M J; Pruett-Jones, S G

    1990-08-01

    Theoretical models of sexual selection assume that females choose males independently of the actions and choice of other individual females. Variance in male mating success in promiscuous species is thus interpreted as a result of phenotypic differences among males which females perceive and to which they respond. Here we show that, if some females copy the behavior of other females in choosing mates, the variance in male mating success and therefore the opportunity for sexual selection is greatly increased. Copying behavior is most likely in non-resource-based harem and lek mating systems but may occur in polygynous, territorial systems as well. It can be shown that copying behavior by females is an adaptive alternative to random choice whenever there is a cost to mate choice. We develop a statistical means of estimating the degree of female copying in natural populations where it occurs. PMID:2377613

  9. 2. Historic American Buildings Survey, Copied by Survey Photographer (e) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Copied by Survey Photographer (e) Ext-Old Photograph- Gen View North and East Elevations, (before 1868) - India Wharf Stores, 306-308 Atlantic Avenue, Boston, Suffolk County, MA

  10. 3. Historic American Buildings Survey, Copied by Survey Photographer. Taken ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Copied by Survey Photographer. Taken before 1868. (f) Ext- Old Photo-- General view from N.W. - India Wharf Stores, 306-308 Atlantic Avenue, Boston, Suffolk County, MA

  11. 1. Historic American Buildings Survey Copied by Survey, Photographer, Old ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Copied by Survey, Photographer, Old Photo before 1880 (a) Ext-General view from Southwest. - Governor Thomas Prence House, King's Highway (U.S. Route 6), Eastham, Barnstable County, MA

  12. 5. Historic American Buildings Survey, COPY OF AN OLD VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, COPY OF AN OLD VIEW IN THE PHILADELPHIANA COLLECTION, LOGAN SQUARE BRANCH, FREE LIBRARY OF PHILADELPHIA, SHOWING BRIDGE BEFORE THE ROADWAY WAS WIDENED. - Chestnut Street Bridge, Schuykill River, Chestnut Street vicinity, Philadelphia, Philadelphia County, PA

  13. 7. Photograph is copy of historic photo (original print located ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photograph is copy of historic photo (original print located in Ogden Air Logistics Center, Hill Air Force Base, Utah). Photographer unknown. - Ogden Arsenal, Primer Loading Building for 37mm Shell Loading, 7726 North Carolina Way, Layton, Davis County, UT

  14. 2. West and south elevation. Copied from an old print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. West and south elevation. Copied from an old print by Joseph Hill, lent to survey by Evelyn S. Craig. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  15. 3. West and south elevations. Joseph Hill, photographer, copied from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. West and south elevations. Joseph Hill, photographer, copied from photo lent by Evelyn S. Craig. August 1936. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  16. 2. Historic American Buildings Survey Copied from an old print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Copied from an old print by Joseph Hill. OLD STORE AND POST OFFICE, FROM 'HISTORIC BISHOP HILL'- EVELYN S. CRAIG - Jansonist Colony, Colony Store & Post Office, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  17. 20. Photographic copy of photograph, circa 1880, photographer unknown (original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Photographic copy of photograph, circa 1880, photographer unknown (original at Rochester Landmark Society, Rochester, New York) VIEW SOUTH, MILITIA ASSEMBLED IN FRONT OF ARSENAL - New York State Arsenal, 75 Woodbury Boulevard, Rochester, Monroe County, NY

  18. 5. Photographic copy of historic photograph (from Wind Cave National ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Photographic copy of historic photograph (from Wind Cave National Park), photographer unknown, date unknown. Route 87, Beaver Creek Bridge, elevation. - Beaver Creek Bridge, Hot Springs, Fall River County, SD

  19. 16. Photo copy of photograph (location of original print unknown) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photo copy of photograph (location of original print unknown) c.1936, photographer unknown Historic view of north approach to bridge - Coos Bay Bridge, Spanning Coos Bay on Oregon Coast Highway, North Bend, Coos County, OR

  20. 17. Photo copy of photograph (location of original print unknown) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Photo copy of photograph (location of original print unknown) c.1936, photographer unknown Historic view of bridge - Coos Bay Bridge, Spanning Coos Bay on Oregon Coast Highway, North Bend, Coos County, OR