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Sample records for 5 mexp 1

  1. MACMULTIVIEW 5.1

    NASA Technical Reports Server (NTRS)

    Norikane, L.

    1994-01-01

    format (standard format readable by MacMultiview and other image processing programs for the Macintosh). Images can also be printed on PostScript output devices. Polarization signatures can be saved in either a PICT format or as a text file containing PostScript commands and printed on any QuickDraw output device. The associated Stokes matrices can be stored in a text file. MacMultiview is written in C-language for Macintosh II series computers. MacMultiview will only run on Macintosh II series computers with 8-bit video displays (gray shades or color). The program also requires a minimum configuration of System 6.0, Finder 6.1, and 1Mb of RAM. MacMultiview is NOT compatible with System 7.0. It requires 32-Bit QuickDraw. Note: MacMultiview may not be fully compatible with preliminary versions of 32-Bit QuickDraw. Macintosh Programmer's Workshop and Macintosh Programmer's Workshop C (version 3.0) are required for recompiling and relinking. The standard distribution medium for this package is a set of three 800K 3.5 inch diskettes in Macintosh format. This program was developed in 1989 and updated in 1991. MacMultiview is a copyrighted work with all copyright vested in NASA. QuickDraw, Finder, Macintosh, and System 7 are trademarks of Apple Computer, Inc.

  2. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  3. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  4. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  5. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  6. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  7. 1,3,5-Trinitrobenzene

    Integrated Risk Information System (IRIS)

    1,3,5 - Trinitrobenzene ; CASRN 99 - 35 - 4 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcino

  8. 5 CFR 5.1 - Civil Service regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Civil Service regulations. 5.1 Section 5.1 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES REGULATIONS, INVESTIGATION, AND ENFORCEMENT (RULE V) § 5.1 Civil Service regulations. The Director, Office of...

  9. 22 CFR 5.1 - Introduction.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Introduction. 5.1 Section 5.1 Foreign Relations DEPARTMENT OF STATE GENERAL ORGANIZATION § 5.1 Introduction. The sections in this part 5 are issued pursuant to section 3 of the Administrative Procedure Act, 5 U.S.C. 552, effective July 4, 1967....

  10. Synthesis of CORONA 5 (Ti-4.5Al-5Mo-1.5Cr)

    NASA Astrophysics Data System (ADS)

    Froes, F. H.; Highberger, W. T.

    1980-05-01

    The synthesis of CORONA 5 (Ti-4.5Al-5Mo-1.5Cr) is described from the viewpoints of alloy chemistry and microstructure. Lenticular alpha is shown to maximize fracture resistance parameters, while a globular alpha optimizes hightemperature flow characteristics. The processing and application of CORONA 5 as forging, plate, sheet and powder metallurgy products are presented. The weldability of the alloy is described and potential use of the alloy for engine applications discussed. The improved mechanical property behavior over the "workhorse" Ti-6Al-4V alloy combined with cost-effective production should result in use of CORONA 5 in many applications. Future developments for CORONA 5 are suggested both in terms of further mechanical property optimization and in light of the economics of producing the alloy.

  11. 6 CFR 5.1 - General provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false General provisions. 5.1 Section 5.1 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY DISCLOSURE OF RECORDS AND INFORMATION Freedom of Information Act § 5.1 General provisions. (a)(1) This subpart A contains the rules that...

  12. 16 CFR 1.5 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Purpose. 1.5 Section 1.5 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE GENERAL PROCEDURES Industry Guidance Industry Guides § 1.5 Purpose. Industry guides are administrative interpretations of...

  13. 26 CFR 1.304-5 - Control.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Control. 1.304-5 Section 1.304-5 Internal... TAXES Effects on Recipients § 1.304-5 Control. (a) Control requirement in general. Section 304(c)(1) provides that, for purposes of section 304, control means the ownership of stock possessing at least...

  14. 49 CFR 5.1 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Applicability. 5.1 Section 5.1 Transportation Office of the Secretary of Transportation RULEMAKING PROCEDURES General § 5.1 Applicability. (a) This... Programs Administration, St. Lawrence Seaway Development Corporation, or Federal Motor Carrier...

  15. 49 CFR 5.1 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Applicability. 5.1 Section 5.1 Transportation Office of the Secretary of Transportation RULEMAKING PROCEDURES General § 5.1 Applicability. (a) This... Programs Administration, St. Lawrence Seaway Development Corporation, or Federal Motor Carrier...

  16. 49 CFR 5.1 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Applicability. 5.1 Section 5.1 Transportation Office of the Secretary of Transportation RULEMAKING PROCEDURES General § 5.1 Applicability. (a) This... Programs Administration, St. Lawrence Seaway Development Corporation, or Federal Motor Carrier...

  17. 49 CFR 5.1 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Applicability. 5.1 Section 5.1 Transportation Office of the Secretary of Transportation RULEMAKING PROCEDURES General § 5.1 Applicability. (a) This... Programs Administration, St. Lawrence Seaway Development Corporation, or Federal Motor Carrier...

  18. 49 CFR 5.1 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Applicability. 5.1 Section 5.1 Transportation Office of the Secretary of Transportation RULEMAKING PROCEDURES General § 5.1 Applicability. (a) This... Programs Administration, St. Lawrence Seaway Development Corporation, or Federal Motor Carrier...

  19. 4 CFR 5.1 - Pay.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Pay. 5.1 Section 5.1 Accounts GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL SYSTEM COMPENSATION § 5.1 Pay. (a) Pay principles. Pay of the employees of GAO shall be... Merit Pay System, the pay of GAO employees shall be adjusted at the same time and to the same extent...

  20. 44 CFR 1.5 - Rules docket.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Rules docket. 1.5 Section 1.5 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL RULEMAKING; POLICY AND PROCEDURES General § 1.5 Rules docket. (a) Documents which are...

  1. 18 CFR 1b.5 - Formal investigations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Formal investigations. 1b.5 Section 1b.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.5 Formal investigations....

  2. 18 CFR 1b.5 - Formal investigations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Formal investigations. 1b.5 Section 1b.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.5 Formal investigations....

  3. 18 CFR 1b.5 - Formal investigations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Formal investigations. 1b.5 Section 1b.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.5 Formal investigations....

  4. 18 CFR 1b.5 - Formal investigations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Formal investigations. 1b.5 Section 1b.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.5 Formal investigations....

  5. 18 CFR 1b.5 - Formal investigations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Formal investigations. 1b.5 Section 1b.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.5 Formal investigations....

  6. Interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors.

    PubMed

    Schoeffter, P; Hoyer, D

    1991-04-17

    Oxymetazoline was recognized with nanomolar affinity by 5-HT1A, 5-HT1B and 5-HT1D binding sites and mimicked the effects of 5-hydroxytryptamine with about the same potency and intrinsic activity as the endogenous amine in the corresponding functional tests. At 5-HT1C receptors, oxymetazoline behaved as a mixed agonist-antagonist. Clonidine had minimal activity. Methiothepin antagonized the effects of oxymetazoline (7.4 less than pKB less than 8.8). Thus, oxymetazoline is a full and potent agonist at 5-HT1A, 5-HT1B and 5-HT1D receptors and a partial agonist at 5-HT1C receptors.

  7. 26 CFR 1.856-5 - Interest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Interest. 1.856-5 Section 1.856-5 Internal... TAXES Real Estate Investment Trusts § 1.856-5 Interest. (a) In general. In computing the percentage requirements in section 856(c) (2)(B) and (3)(B), the term “interest” includes only an amount which...

  8. 36 CFR 5.1 - Advertisements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Advertisements. 5.1 Section 5... AND PRIVATE OPERATIONS § 5.1 Advertisements. Commercial notices or advertisements shall not be... or advertisement is of goods, services, or facilities available within the park area and such...

  9. 43 CFR 9239.5-1 - Ores.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Ores. 9239.5-1 Section 9239.5-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR TECHNICAL SERVICES (9000) TRESPASS Kinds of Trespass § 9239.5-1 Ores. (a) For...

  10. 43 CFR 9239.5-1 - Ores.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Ores. 9239.5-1 Section 9239.5-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR TECHNICAL SERVICES (9000) TRESPASS Kinds of Trespass § 9239.5-1 Ores. (a) For...

  11. 43 CFR 9239.5-1 - Ores.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Ores. 9239.5-1 Section 9239.5-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR TECHNICAL SERVICES (9000) TRESPASS Kinds of Trespass § 9239.5-1 Ores. (a) For...

  12. 43 CFR 9239.5-1 - Ores.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Ores. 9239.5-1 Section 9239.5-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR TECHNICAL SERVICES (9000) TRESPASS Kinds of Trespass § 9239.5-1 Ores. (a) For...

  13. 14 CFR Sec. 1-5 - Records.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... with 14 CFR part 249 for the preservation of records. ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Records. Sec. 1-5 Section 1-5 Aeronautics... Provisions Sec. 1-5 Records. (a) The general books of account and all books, records, and memoranda...

  14. 5 CFR 1645.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Definitions. 1645.1 Section 1645.1 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD CALCULATION OF SHARE PRICES § 1645.1 Definitions. (a) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1....

  15. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  16. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  17. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  18. 1 CFR 18.5 - Certified copies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Certified copies. 18.5 Section 18.5 General... DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.5 Certified copies. The certified copies or duplicate originals of each document must be submitted with the original. Each copy or...

  19. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  20. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  1. 41 CFR 60-1.5 - Exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Exemptions. 60-1.5 Section 60-1.5 Public Contracts and Property Management Other Provisions Relating to Public Contracts... for a school, college, university, or other educational institution or institution of learning to...

  2. 41 CFR 51-5.1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... determination may be required. In order to assist in evaluating the suitability of an Office of Management and... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true General. 51-5.1 Section 51-5.1 Public Contracts and Property Management Other Provisions Relating to Public...

  3. 41 CFR 60-1.5 - Exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 1 2013-07-01 2013-07-01 false Exemptions. 60-1.5 Section 60-1.5 Public Contracts and Property Management Other Provisions Relating to Public Contracts...-OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS Preliminary Matters; Equal Opportunity Clause;...

  4. 41 CFR 60-1.5 - Exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Exemptions. 60-1.5 Section 60-1.5 Public Contracts and Property Management Other Provisions Relating to Public Contracts...-OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS Preliminary Matters; Equal Opportunity Clause;...

  5. 5 CFR 1650.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... SAVINGS PLAN General § 1650.1 Definitions. (a) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this part: In-service withdrawal means an age-based or... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Definitions. 1650.1 Section...

  6. 5 CFR 1650.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... SAVINGS PLAN General § 1650.1 Definitions. (a) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this part: In-service withdrawal means an age-based or... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Definitions. 1650.1 Section...

  7. 5 CFR 1650.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... SAVINGS PLAN General § 1650.1 Definitions. (a) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this part: In-service withdrawal means an age-based or... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Definitions. 1650.1 Section...

  8. 5 CFR 1650.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SAVINGS PLAN General § 1650.1 Definitions. (a) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this part: In-service withdrawal means an age-based or... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Definitions. 1650.1 Section...

  9. 32 CFR 1280.5 - Procedures. 1

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Procedures. 1 1280.5 Section 1280.5 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS INVESTIGATING AND PROCESSING CERTAIN NONCONTRACTUAL CLAIMS AND REPORTING RELATED LITIGATION § 1280.5...

  10. 32 CFR 1280.5 - Procedures. 1

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Procedures. 1 1280.5 Section 1280.5 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS INVESTIGATING AND PROCESSING CERTAIN NONCONTRACTUAL CLAIMS AND REPORTING RELATED LITIGATION § 1280.5...

  11. 32 CFR 1280.5 - Procedures. 1

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Procedures. 1 1280.5 Section 1280.5 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS INVESTIGATING AND PROCESSING CERTAIN NONCONTRACTUAL CLAIMS AND REPORTING RELATED LITIGATION § 1280.5...

  12. 32 CFR 1280.5 - Procedures. 1

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Procedures. 1 1280.5 Section 1280.5 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS INVESTIGATING AND PROCESSING CERTAIN NONCONTRACTUAL CLAIMS AND REPORTING RELATED LITIGATION § 1280.5...

  13. 26 CFR 1.304-5 - Control.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... relevant control group the person or persons that retain or acquire acquiring corporation stock in the...) also does not apply to A because A (or any control group of which A was a member) did not control T... 26 Internal Revenue 4 2011-04-01 2011-04-01 false Control. 1.304-5 Section 1.304-5...

  14. 5 CFR 1206.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... conduct open meetings in accordance with the Government in the Sunshine Act (5 U.S.C. 552b) (“the Act”). ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Purpose. 1206.1 Section 1206.1 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES OPEN MEETINGS Purpose...

  15. H5N1 Avian Flu (H5N1 Bird Flu)

    MedlinePlus

    ... H5N1 - Avian/Bird Flu H5N1 Avian Flu - H5N1 Bird Flu H5N1 is a highly pathogenic avian (bird) flu virus that has caused serious outbreaks in ... been no reported infections with these viruses in birds, poultry, or people in the United States. You ...

  16. 5 CFR 10.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Definitions. 10.1 Section 10.1 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES AGENCY ACCOUNTABILITY SYSTEMS; OPM AUTHORITY TO REVIEW PERSONNEL MANAGEMENT PROGRAMS (RULE X) § 10.1 Definitions. For purposes of this rule—...

  17. 5 CFR 10.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Definitions. 10.1 Section 10.1 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES AGENCY ACCOUNTABILITY SYSTEMS; OPM AUTHORITY TO REVIEW PERSONNEL MANAGEMENT PROGRAMS (RULE X) § 10.1 Definitions. For purposes of this rule—...

  18. 5 CFR 10.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Definitions. 10.1 Section 10.1 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES AGENCY ACCOUNTABILITY SYSTEMS; OPM AUTHORITY TO REVIEW PERSONNEL MANAGEMENT PROGRAMS (RULE X) § 10.1 Definitions. For purposes of this rule—...

  19. 5 CFR 10.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Definitions. 10.1 Section 10.1 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES AGENCY ACCOUNTABILITY SYSTEMS; OPM AUTHORITY TO REVIEW PERSONNEL MANAGEMENT PROGRAMS (RULE X) § 10.1 Definitions. For purposes of this rule—...

  20. 5 CFR 1.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Definitions. 1.3 Section 1.3 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.3 Definitions. As used in the rules in this subchapter: (a) Competitive service shall have the...

  1. 5 CFR 1501.1 - Name.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Name. 1501.1 Section 1501.1 Administrative Personnel THE INTERNATIONAL ORGANIZATIONS EMPLOYEES LOYALTY BOARD OPERATIONS OF THE INTERNATIONAL ORGANIZATIONS EMPLOYEES LOYALTY BOARD § 1501.1 Name. This Board shall be known as the...

  2. 5 CFR 1501.1 - Name.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Name. 1501.1 Section 1501.1 Administrative Personnel THE INTERNATIONAL ORGANIZATIONS EMPLOYEES LOYALTY BOARD OPERATIONS OF THE INTERNATIONAL ORGANIZATIONS EMPLOYEES LOYALTY BOARD § 1501.1 Name. This Board shall be known as the...

  3. 5 CFR 1315.1 - Application.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Application. 1315.1 Section 1315.1 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.1 Application. (a... Law 93-288, as amended (42 U.S.C. 5121 et seq.)); military contingency operations (as defined in 10...

  4. 5 CFR 1315.1 - Application.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Application. 1315.1 Section 1315.1 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.1 Application. (a... Law 93-288, as amended (42 U.S.C. 5121 et seq.)); military contingency operations (as defined in 10...

  5. 5 CFR 1315.1 - Application.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Application. 1315.1 Section 1315.1 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.1 Application. (a... Law 93-288, as amended (42 U.S.C. 5121 et seq.)); military contingency operations (as defined in 10...

  6. 5 CFR 1315.1 - Application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Application. 1315.1 Section 1315.1 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.1 Application. (a... Law 93-288, as amended (42 U.S.C. 5121 et seq.)); military contingency operations (as defined in 10...

  7. 5 CFR 9.1 - Definition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Definition. 9.1 Section 9.1... Definition. As used in this rule, 'Executive agency' means an Executive department, a Government corporation... Code, but does not include the Federal Bureau of Investigation, the Central Intelligence Agency,...

  8. 5 CFR 1601.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Definitions. 1601.1 Section 1601.1 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD PARTICIPANTS' CHOICES OF TSP FUNDS General... CFR 1690.1. (b) As used in this part: Acknowledgment of risk means an acknowledgment that...

  9. 5 CFR 1651.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this... death benefit specified in 5 U.S.C. 8424(d). TIN means a taxpayer identification number. A TIN may be...

  10. 5 CFR 1651.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this... death benefit specified in 5 U.S.C. 8424(d). TIN means a taxpayer identification number. A TIN may be...

  11. 5 CFR 1651.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this... Social Security number (SSN), an employer identification number (EIN), or an individual...

  12. 5 CFR 1651.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this... Social Security number (SSN), an employer identification number (EIN), or an individual...

  13. 5 CFR 1651.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this... Social Security number (SSN), an employer identification number (EIN), or an individual...

  14. SpaceCube Version 1.5

    NASA Technical Reports Server (NTRS)

    Geist, Alessandro; Lin, Michael; Flatley, Tom; Petrick, David

    2013-01-01

    SpaceCube 1.5 is a high-performance and low-power system in a compact form factor. It is a hybrid processing system consisting of CPU (central processing unit), FPGA (field-programmable gate array), and DSP (digital signal processor) processing elements. The primary processing engine is the Virtex- 5 FX100T FPGA, which has two embedded processors. The SpaceCube 1.5 System was a bridge to the SpaceCube 2.0 and SpaceCube 2.0 Mini processing systems. The SpaceCube 1.5 system was the primary avionics in the successful SMART (Small Rocket/Spacecraft Technology) Sounding Rocket mission that was launched in the summer of 2011. For SMART and similar missions, an avionics processor is required that is reconfigurable, has high processing capability, has multi-gigabit interfaces, is low power, and comes in a rugged/compact form factor. The original SpaceCube 1.0 met a number of the criteria, but did not possess the multi-gigabit interfaces that were required and is a higher-cost system. The SpaceCube 1.5 was designed with those mission requirements in mind. The SpaceCube 1.5 features one Xilinx Virtex-5 FX100T FPGA and has excellent size, weight, and power characteristics [4×4×3 in. (approx. = 10×10×8 cm), 3 lb (approx. = 1.4 kg), and 5 to 15 W depending on the application]. The estimated computing power of the two PowerPC 440s in the Virtex-5 FPGA is 1100 DMIPS each. The SpaceCube 1.5 includes two Gigabit Ethernet (1 Gbps) interfaces as well as two SATA-I/II interfaces (1.5 to 3.0 Gbps) for recording to data drives. The SpaceCube 1.5 also features DDR2 SDRAM (double data rate synchronous dynamic random access memory); 4- Gbit Flash for storing application code for the CPU, FPGA, and DSP processing elements; and a Xilinx Platform Flash XL to store FPGA configuration files or application code. The system also incorporates a 12 bit analog to digital converter with the ability to read 32 discrete analog sensor inputs. The SpaceCube 1.5 design also has a built

  15. 5 CFR 1650.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SAVINGS PLAN General § 1650.1 Definitions. (a) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this part: In-service withdrawal means an age-based or financial hardship withdrawal from the TSP that may be available to a participant who has not yet...

  16. 5 CFR 1653.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD COURT ORDERS AND LEGAL PROCESSES AFFECTING THRIFT SAVINGS PLAN ACCOUNTS Retirement Benefits Court Orders § 1653.1 Definitions. (a) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this...

  17. 5 CFR 1653.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD COURT ORDERS AND LEGAL PROCESSES AFFECTING THRIFT SAVINGS PLAN ACCOUNTS Retirement Benefits Court Orders § 1653.1 Definitions. (a) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this...

  18. 5 CFR 1653.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD COURT ORDERS AND LEGAL PROCESSES AFFECTING THRIFT SAVINGS PLAN ACCOUNTS Retirement Benefits Court Orders § 1653.1 Definitions. (a) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this...

  19. 5 CFR 1653.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD COURT ORDERS AND LEGAL PROCESSES AFFECTING THRIFT SAVINGS PLAN ACCOUNTS Retirement Benefits Court Orders § 1653.1 Definitions. (a) Definitions generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this...

  20. 5 CFR 9301.1 - In general.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false In general. 9301.1 Section 9301.1 Administrative Personnel SPECIAL INSPECTOR GENERAL FOR AFGHANISTAN RECONSTRUCTION DISCLOSURE OF RECORDS AND INFORMATION Freedom of Information Act Procedures for Disclosure of Records Under the Freedom of...

  1. 5 CFR 9301.1 - In general.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false In general. 9301.1 Section 9301.1 Administrative Personnel SPECIAL INSPECTOR GENERAL FOR AFGHANISTAN RECONSTRUCTION DISCLOSURE OF RECORDS AND INFORMATION Freedom of Information Act Procedures for Disclosure of Records Under the Freedom of...

  2. Facile 1,3- and 1,5-Chlorine Migration.

    PubMed

    Koch, Rainer; Wong, Ming Wah; Wentrup, Curt

    1996-10-01

    High-level ab initio molecular orbital calculations, using the G2(MP2,SVP) theory (and semiempirical methods) have been used to examine several 1,3- and 1,5-chlorine migrations. It is found that the interaction of chlorine lone pair electrons with a low-lying LUMO accelerates the Cl shift dramatically (lone pair-LUMO-mediated pericyclic reaction). The activation barriers for the 1,3-migration in chloro oxo ketene 1 (Cl(C=O)CH=C=O) and the 1,5-migration in (2-(chlorocarbonyl)vinyl)ketene 2 (Cl(C=O)CH=CHCH=C=O) are only 53 and 61 kJ mol(-)(1), respectively, compared to the 216 and 173 kJ mol(-)(1) barriers for the corresponding unassisted 1,3- and 1,5-sigmatropic shifts of Cl in 3-chloro-1-propene and 5-chloro-1,3-pentadiene. The transition structures for 1 and 2 reveal that migration of the chlorine atoms takes place in the molecular planes. The 1,5-chlorine shift in 6-chlorocyclohexa-2,4-dienone (3) has a significantly higher barrier due to a lack of appropriate orbital interaction. The related 1,3-shift in the (chlorocarbonyl)imine-alpha-chloro isocyanate system is also dramatically accelerated compared with conventional pericyclic 1,3-Cl migration.

  3. KIAE-1.5-3 undulator performance

    SciTech Connect

    Varfolomeev, A.A.; Ivanchenko, S.N.; Khlebnikov, A.S.

    1995-12-31

    Hybrid type undulator with 60 periods of {lambda}{sub w} = 1.5 cm and tunable gap in wide range has been designed and manufactured. Additional side magnet arrays provide high magnetic field (near Halbach limit) along with transverse field profiles for e.b. focusing.

  4. 1,2,4,5-Tetrachlorobenzene

    Integrated Risk Information System (IRIS)

    1,2,4,5 - Tetrachlorobenzene ; CASRN 95 - 94 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Nonca

  5. 45 CFR 5.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... § 5.1 Purpose. This part contains the rules that the Department of Health and Human Services (HHS... make a FOIA request; who can release records and who can decide not to release; how much time it should take to make a determination regarding release; what fees may be charged; what records are...

  6. 5 CFR 1653.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD COURT ORDERS AND LEGAL PROCESSES AFFECTING... generally applicable to the Thrift Savings Plan are set forth at 5 CFR 1690.1. (b) As used in this subpart... proceeding. TSP investment earnings or earnings means both positive and negative fund...

  7. 14 CFR Sec. 1-5 - Records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Provisions Sec. 1-5 Records. (a) The general books of account and all books, records, and memoranda which... Accounts. Registers, or other appropriate records, shall be maintained of the history and nature of each note receivable and each note payable. (b) The books and records referred to herein include not...

  8. 14 CFR 1-5 - Records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... with 14 CFR part 249 for the preservation of records. ... Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC... Provisions Sec. 1-5 Records. (a) The general books of account and all books, records, and memoranda...

  9. 5 CFR 10.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES AGENCY ACCOUNTABILITY SYSTEMS; OPM AUTHORITY TO REVIEW PERSONNEL MANAGEMENT PROGRAMS (RULE X) § 10.1 Definitions. For purposes of this rule— (a... personnel management that are set forth in section 2301(b) of title 5, United States Code....

  10. 26 CFR 1.812-5 - Offset.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... and Loss from Operations § 1.812-5 Offset. (a) Offset defined. Section 812(d) defines the term “offset... is necessary to reduce the life insurance company taxable income (computed without regard to section... taxable year as were sustained in taxable years preceding the taxable year in which the life...

  11. 5 CFR 9.1 - Definition.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., and an independent establishment, as those terms are defined in chapter 1 of title 5, United States Code, but does not include the Federal Bureau of Investigation, the Central Intelligence Agency, the... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES WORKFORCE INFORMATION (RULE IX) §...

  12. 5 CFR 9.1 - Definition.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., and an independent establishment, as those terms are defined in chapter 1 of title 5, United States Code, but does not include the Federal Bureau of Investigation, the Central Intelligence Agency, the... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES WORKFORCE INFORMATION (RULE IX) §...

  13. 5 CFR 9.1 - Definition.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., and an independent establishment, as those terms are defined in chapter 1 of title 5, United States Code, but does not include the Federal Bureau of Investigation, the Central Intelligence Agency, the... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES WORKFORCE INFORMATION (RULE IX) §...

  14. 5 CFR 9.1 - Definition.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., and an independent establishment, as those terms are defined in chapter 1 of title 5, United States Code, but does not include the Federal Bureau of Investigation, the Central Intelligence Agency, the... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES WORKFORCE INFORMATION (RULE IX) §...

  15. Biodegradation of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine

    PubMed Central

    McCormick, N. G.; Cornell, J. H.; Kaplan, A. M.

    1981-01-01

    Biodegradation of the explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) occurs under anaerobic conditions, yielding a number of products, including: hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine, hexahydro-1,3-dinitroso-5-nitro-1,3,5-triazine, hexahydro-1,3,5-trinitroso-1,3,5-triazine, hydrazine, 1,1-dimethyl-hydrazine, 1,2-dimethylhydrazine, formaldehyde, and methanol. A scheme for the biodegradation of RDX is proposed which proceeds via successive reduction of the nitro groups to a point where destabilization and fragmentation of the ring occurs. The noncyclic degradation products arise via subsequent reduction and rearrangement reactions of the fragments. The scheme suggests the presence of several additional compounds, not yet identified. Several of the products are mutagenic or carcinogenic or both. Anaerobic treatment of RDX wastewaters, which also contain high nitrate levels, would permit the denitrification to occur, with concurrent degradation of RDX ultimately to a mixture of hydrazines and methanol. The feasibility of using an aerobic mode in the further degradation of these products is discussed. PMID:16345884

  16. Fragrance material review on 1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one.

    PubMed

    Scognamiglio, J; Letizia, C S; Api, A M

    2013-12-01

    A toxicologic and dermatologic review of 1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one when used as a fragrance ingredient is presented. 1-(2,4,4,5,5-Pentamethyl-1-cyclopenten-1-yl)ethan-1-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, phototoxicity, and photoallergy data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A Toxicologic and Dermatologic Assessment of Alkyl Cyclic Ketones When Used as Fragrance Ingredients (submitted for publication)) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances.

  17. Thermophysical properties of Ti-5Al-5V-5Mo-3Cr-1Zr titanium alloy

    NASA Astrophysics Data System (ADS)

    Bykov, V. A.; Kulikova, T. V.; Vedmid', L. B.; Fishman, A. Ya.; Shunyaev, K. Yu.; Tarenkova, N. Yu.

    2014-07-01

    The thermophysical properties of the Ti-5Al-5V-5Mo-3Cr-1Zr titanium alloy in a wide range of temperatures from room temperature to 1000°C have been studied by the methods of differential scanning calorimetry, the laser flash method, and dilatometry. The obtained data on heat capacity, thermal diffusivity, and thermal expansion have been used for calculating coefficient of thermal conductivity. The sequence and temperatures of structural transformations during heating of the alloy have been established. It has been shown that the studied alloy possesses a coefficient of thermal conductivity that is 3.5-4 times smaller than that of pure titanium.

  18. Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

    Integrated Risk Information System (IRIS)

    Hexahydro - 1,3,5 - trinitro - 1,3,5 - triazine ( RDX ) ; CASRN 121 - 82 - 4 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health

  19. Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)

    Integrated Risk Information System (IRIS)

    Octahydro - 1,3,5,7 - tetranitro - 1,3,5,7 - tetr . . . ( HMX ) ; CASRN 2691 - 41 - 0 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I

  20. RU 24969-induced emesis in the cat - 5-HT1 sites other than 5-HT1A, 5-HT1B or 5-HT1C implicated

    NASA Technical Reports Server (NTRS)

    Lucot, James B.

    1990-01-01

    RU 24969 was administered s.c. to cats and found to elicit emesis with a maximally effective dose of 1.0 mg/kg 5-Methoxytryptamine was found to have lower efficacy and to produce a higher incidence of nonspecific effects while trifluoromethylphenylpiperizine (TFMPP) was devoid of emetic effects. The emesis elicited by 1.0 mg/kg of RU 24969 was not altered by pretreatment with phentolamine, haloperidol, yohimbine or (-)-propranolol, indicating that catecholamines played no role in this response. The emesis was prevented by metergoline and methysergide but not by ketanserin, cyproheptadine, mesulergine, ICS 205 930, methiothepin, trimethobenzamide or BMY 7378. An indirect argument is presented that implicates a role for 5-HT1D sites. This conclusion must remain tentative until drugs selective for this site are synthesized and tested. The emesis was also prevented by 8-hydroxy-2-(di-n-propylamine)tetralin (8-OH-DPAT), confirming that this drug has a general antiemetic effect in cats.

  1. H5N1 vaccines in humans

    PubMed Central

    Baz, Mariana; Luke, Catherine J; Cheng, Xing; Jin, Hong; Subbarao, Kanta

    2013-01-01

    The spread of highly pathogenic avian H5N1 influenza viruses since 1997 and their virulence for poultry and humans has raised concerns about their potential to cause an influenza pandemic. Vaccines offer the most viable means to combat a pandemic threat. However, it will be a challenge to produce, distribute and implement a new vaccine if a pandemic spreads rapidly. Therefore, efforts are being undertaken to develop pandemic vaccines that use less antigen and induce cross-protective and long-lasting responses, that can be administered as soon as a pandemic is declared or possibly even before, in order to prime the population and allow for a rapid and protective antibody response. In the last few years, several vaccine manufacturers have developed candidate pandemic and pre-pandemic vaccines, based on reverse genetics and have improved the immunogenicity by formulating these vaccines with different adjuvants. Some of the important and consistent observations from clinical studies with H5N1 vaccines are as follows: two doses of inactivated vaccine are generally necessary to elicit the level of immunity required to meet licensure criteria, less antigen can be used if an oil-in-water adjuvant is included, in general antibody titers decline rapidly but can be boosted with additional doses of vaccine and if high titers of antibody are elicited, cross-reactivity against other clades is observed. Prime-boost strategies elicit a more robust immune response. In this review, we discuss data from clinical trials with a variety of H5N1 influenza vaccines. We also describe studies conducted in animal models to explore the possibility of reassortment between pandemic live attenuated vaccine candidates and seasonal influenza viruses, since this is an important consideration for the use of live vaccines in a pandemic setting. PMID:23726847

  2. TOUGH+ v1.5 Core Code

    2015-08-27

    TOUGH+ v1.5 is a numerical code for the simulation of multi-phase, multi-component flow and transport of mass and heat through porous and fractured media, and represents the third update of the code since its first release [Moridis et al., 2008]. TOUGH+ is a successor to the TOUGH2 [Pruess et al., 1991; 2012] family of codes for multi-component, multiphase fluid and heat flow developed at the Lawrence Berkeley National Laboratory. It is written in standard FORTRANmore » 95/2003, and can be run on any computational platform (workstations, PC, Macintosh). TOUGH+ v1.5 employs dynamic memory allocation, thus minimizing storage requirements. It has a completely modular structure, follows the tenets of Object-Oriented Programming (OOP), and involves the advanced features of FORTRAN 95/2003, i.e., modules, derived data types, the use of pointers, lists and trees, data encapsulation, defined operators and assignments, operator extension and overloading, use of generic procedures, and maximum use of the powerful intrinsic vector and matrix processing operations. TOUGH+ v1.5 is the core code for its family of applications, i.e., the part of the code that is common to all its applications. It provides a description of the underlying physics and thermodynamics of non-isothermal flow, of the mathematical and numerical approaches, as well as a detailed explanation of the general (common to all applications) input requirements, options, capabilities and output specifications. The core code cannot run by itself: it needs to be coupled with the code for the specific TOUGH+ application option that describes a particular type of problem. The additional input requirements specific to a particular TOUGH+ application options and related illustrative examples can be found in the corresponding User’s Manual.« less

  3. TOUGH+ v1.5 Core Code

    SciTech Connect

    Moridis, George J.

    2015-08-27

    TOUGH+ v1.5 is a numerical code for the simulation of multi-phase, multi-component flow and transport of mass and heat through porous and fractured media, and represents the third update of the code since its first release [Moridis et al., 2008]. TOUGH+ is a successor to the TOUGH2 [Pruess et al., 1991; 2012] family of codes for multi-component, multiphase fluid and heat flow developed at the Lawrence Berkeley National Laboratory. It is written in standard FORTRAN 95/2003, and can be run on any computational platform (workstations, PC, Macintosh). TOUGH+ v1.5 employs dynamic memory allocation, thus minimizing storage requirements. It has a completely modular structure, follows the tenets of Object-Oriented Programming (OOP), and involves the advanced features of FORTRAN 95/2003, i.e., modules, derived data types, the use of pointers, lists and trees, data encapsulation, defined operators and assignments, operator extension and overloading, use of generic procedures, and maximum use of the powerful intrinsic vector and matrix processing operations. TOUGH+ v1.5 is the core code for its family of applications, i.e., the part of the code that is common to all its applications. It provides a description of the underlying physics and thermodynamics of non-isothermal flow, of the mathematical and numerical approaches, as well as a detailed explanation of the general (common to all applications) input requirements, options, capabilities and output specifications. The core code cannot run by itself: it needs to be coupled with the code for the specific TOUGH+ application option that describes a particular type of problem. The additional input requirements specific to a particular TOUGH+ application options and related illustrative examples can be found in the corresponding User’s Manual.

  4. Benzene-1,3,5-triyl tribenzoate

    PubMed Central

    Corfield, Peter W. R.; Balija, Amy M.

    2013-01-01

    The title compound, C27H18O6, commonly known as phloroglucinol tribenzoate, is a standard unit for the family of benzyl ether dendrimers. The central phloroglucinol residue is close to planar, with out-of-plane distances for the three oxygen atoms of up to 0.095 (3) Å, while the three attached benzoate groups are approximately planar. One benzoate group is twisted [C—C—O—C torsion angle = 98.2 (3)°] from the central plane, with its carbonyl O atom 2.226 (4) Å above that plane, while the other two benzoate groups are twisted in the opposite direction [C—C—O—C torsion angles = 24.7 (2) and 54.8 (2)°], so that their carbonyl O atoms are on the other side of, and closer to the central plane, with distances from the plane of 1.743 (4) and 1.206 (4) Å. One benzoate group is disordered between two conformers, with occupancies of 86.9 (3) and 13.1 (3)%, related by a 143 (1)° rotation about the bond to the central benzene ring. The phenyl groups of the two conformers occupy the same space. The mol­ecule packs in the crystal with two of the three benzoate phenyl rings stacked parallel to symmetry-related counterparts, with perpendicular distances of 3.715 (5) and 3.791 (5) Å. The parallel rings are slipped away from each other, however, with centroid–centroid distances of 4.122 (2) and 4.363 (2) Å, respectively. PMID:24454248

  5. 5 CFR 1690.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... beneficiary participant account pursuant to 5 U.S.C. 8433(e) and in accordance with 5 CFR 1651.19. Beneficiary participant account means an account maintained pursuant to 5 U.S.C. 8433(e) and in accordance with 5 CFR 1651... fully described in 5 CFR 1604.2. Share means a portion of a TSP Fund. Transactions are posted...

  6. 5 CFR 1690.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... beneficiary participant account pursuant to 5 U.S.C. 8433(e) and in accordance with 5 CFR 1651.19. Beneficiary participant account means an account maintained pursuant to 5 U.S.C. 8433(e) and in accordance with 5 CFR 1651... fully described in 5 CFR 1604.2. Share means a portion of a TSP Fund. Transactions are posted...

  7. Fragrance material review on 1-(2,5,5-trimethylcycloheptyl)ethan-1-one.

    PubMed

    Scognamiglio, J; Letizia, C S; Api, A M

    2013-12-01

    A toxicologic and dermatologic review of 1-(2,5,5-trimethylcycloheptyl)ethan-1-one when used as a fragrance ingredient is presented. 1-(2,5,5-Trimethylcycloheptyl)ethan-1-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1-(2,5,5-trimethylcycloheptyl)ethan-1-one were evaluated then summarized and includes physical properties, skin irritation, mucous membrane (eye) irritation, and skin sensitization data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A toxicologic and dermatologic assessment of alkyl cyclic ketones when used as fragrance ingredients. (submitted for publication)) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances.

  8. CRUST 5.1: A global crustal model at 5° x 5°

    USGS Publications Warehouse

    Mooney, Walter D.; Laske, Gabi; Masters, T. Guy

    1998-01-01

    We present a new global model for the Earth's crust based on seismic refraction data published in the period 1948–1995 and a detailed compilation of ice and sediment thickness. An extensive compilation of seismic refraction measurements has been used to determine the crustal structure on continents and their margins. Oceanic crust is modeled with both a standard model for normal oceanic crust, and variants for nonstandard regions, such as oceanic plateaus. Our model (CRUST 5.1) consists of 2592 5° × 5° tiles in which the crust and uppermost mantle are described by eight layers: (1) ice, (2) water, (3) soft sediments, (4) hard sediments, (5) crystalline upper, (6) middle, (7) lower crust, and (8) uppermost mantle. Topography and bathymetry are adopted from a standard database (ETOPO-5). Compressional wave velocity in each layer is based on field measurements, and shear wave velocity and density are estimated using recently published empirical Vp- Vs and Vp-density relationships. The crustal model differs from previous models in that (1) the thickness and seismic/density structure of sedimentary basins is accounted for more completely, (2) the velocity structure of unmeasured regions is estimated using statistical averages that are based on a significantly larger database of crustal structure, (3) the compressional wave, shear wave, and density structure have been explicitly specified using newly available constraints from field and laboratory studies. Thus this global crustal model is based on substantially more data than previous models and differs from them in many important respects. A new map of the thickness of the Earth's crust is presented, and we illustrate the application of this model by using it to provide the crustal correction for surface wave phase velocity maps. Love waves at 40 s are dominantly sensitive to crustal structure, and there is a very close correspondence between observed phase velocities at this period and those predicted by CRUST 5.1

  9. Synthesis and acid-catalyzed transformations of 1-(1,6,6-trimethylbicyclo(2. 1. 1)hex-5-yl)-1-alkanones and 1-(1,6,6-trimethylbicyclo-(2. 1. 1)hex-5-yl)-1-alken-1-ones

    SciTech Connect

    Volkova, O.O.; Cherkaev, G.V.; Novikov, N.A.; Erman, M.B.; Aul'chenko, I.S.; Mochalin, V.B.

    1988-06-20

    The reaction of 1,6,6-trimethylbicyclo(2.1.1)hexane-5-carbaldehyde (photocitral B) with Grignard reagents followed by oxidation of the obtained alcohols gave 1-(1,6,6-trimethylbicyclo(2.1.1)hex-5-yl)-1-alkanones and 1-(1,6,6-trimethylbicyclo(2.1.1)hex-5-yl)-1-alken-1-ones, which isomerize to 1-(2,3,3-trimethyl-1-cyclopentenyl)-2-alkanones when heated in the presence of p-toluenesulfonic acid. It was shown that the intermediate compounds in this reaction are 1-(2,2,3-trimethyl-3-cyclopentenyl)-2-alkanones. Underanalogous conditions photocitral B isomerizes to /alpha/-campholenaldehyde.

  10. 5 CFR 1690.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ....S.C. 8433(e) and in accordance with 5 CFR 1651.19. Beneficiary participant account means an account maintained pursuant to 5 U.S.C. 8433(e) and in accordance with 5 CFR 1651.19. The term includes both civilian... limit of 26 U.S.C. 402(g) and meet the requirements of 5 CFR 1600.23. Civilian account means a...

  11. 5 CFR 1690.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....S.C. 8433(e) and in accordance with 5 CFR 1651.19. Beneficiary participant account means an account maintained pursuant to 5 U.S.C. 8433(e) and in accordance with 5 CFR 1651.19. The term includes both civilian... limit of 26 U.S.C. 402(g) and meet the requirements of 5 CFR 1600.23. Civilian account means a...

  12. 5 CFR 1690.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... more fully described in 5 CFR 1604.2. Share means a portion of a TSP Fund. Transactions are posted to... system by which TSP participants may, among other things, access their accounts by telephone. The Thrift... established pursuant to 5 U.S.C. 8438 and an investment allocation fund established pursuant to 5 CFR...

  13. Biocatalytic ammonolysis of (5S)-4,5-dihydro-1H-pyrrole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl)-5-ethyl ester: preparation of an intermediate to the dipeptidyl peptidase IV inhibitor Saxagliptin.

    PubMed

    Gill, Iqbal; Patel, Ramesh

    2006-02-01

    An efficient biocatalytic method has been developed for the conversion of (5S)-4,5-dihydro-1H-pyrrole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl)-5-ethyl ester (1) into the corresponding amide (5S)-5-aminocarbonyl-4,5-dihydro-1H-pyrrole-1-carboxylic acid, 1-(1,1-dimethylethyl)ester (2), which is a critical intermediate in the synthesis of the dipeptidyl peptidase IV (DPP4) inhibitor Saxagliptin (3). Candida antartica lipase B mediates ammonolysis of the ester with ammonium carbamate as ammonia donor to yield up to 71% of the amide. The inclusion of Ascarite and calcium chloride as adsorbents for carbon dioxide and ethanol byproducts, respectively, increases the yield to 98%, thereby offering an efficient and practical alternative to chemical routes which yield 57-64%. PMID:16257208

  14. Biocatalytic ammonolysis of (5S)-4,5-dihydro-1H-pyrrole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl)-5-ethyl ester: preparation of an intermediate to the dipeptidyl peptidase IV inhibitor Saxagliptin.

    PubMed

    Gill, Iqbal; Patel, Ramesh

    2006-02-01

    An efficient biocatalytic method has been developed for the conversion of (5S)-4,5-dihydro-1H-pyrrole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl)-5-ethyl ester (1) into the corresponding amide (5S)-5-aminocarbonyl-4,5-dihydro-1H-pyrrole-1-carboxylic acid, 1-(1,1-dimethylethyl)ester (2), which is a critical intermediate in the synthesis of the dipeptidyl peptidase IV (DPP4) inhibitor Saxagliptin (3). Candida antartica lipase B mediates ammonolysis of the ester with ammonium carbamate as ammonia donor to yield up to 71% of the amide. The inclusion of Ascarite and calcium chloride as adsorbents for carbon dioxide and ethanol byproducts, respectively, increases the yield to 98%, thereby offering an efficient and practical alternative to chemical routes which yield 57-64%.

  15. Hexahydro-1,3,5-trinitro-1,3,5-triazine translocation in poplar trees

    SciTech Connect

    Thompson, P.L.; Ramer, L.A.; Schnoor, J.L.

    1999-02-01

    This article evaluates the translocation of the explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in hybrid poplar trees (Populus deltoides x nigra, DN34) grown in hydroponic solutions. Mass balances with [U-{sup 14}C]RDX were used to assess RDX translocation. Up to 60% of the RDX uptaken by the tree accumulated in leaf tissues. Analysis of plant extracts by high-performance liquid chromatography equipped with radiochemical detection indicated that RDX was not significantly transformed during exposure periods of up to 7 d. The bioaccumulation of RDX may be an important concern for phytoremediation efforts.

  16. IAC-1.5 - INTEGRATED ANALYSIS CAPABILITY

    NASA Technical Reports Server (NTRS)

    Vos, R. G.

    1994-01-01

    The objective of the Integrated Analysis Capability (IAC) system is to provide a highly effective, interactive analysis tool for the integrated design of large structures. IAC was developed to interface programs from the fields of structures, thermodynamics, controls, and system dynamics with an executive system and a database to yield a highly efficient multi-disciplinary system. Special attention is given to user requirements such as data handling and on-line assistance with operational features, and the ability to add new modules of the user's choice at a future date. IAC contains an executive system, a database, general utilities, interfaces to various engineering programs, and a framework for building interfaces to other programs. IAC has shown itself to be effective in automating data transfer among analysis programs. The IAC system architecture is modular in design. 1) The executive module contains an input command processor, an extensive data management system, and driver code to execute the application modules. 2) Technical modules provide standalone computational capability as well as support for various solution paths or coupled analyses. 3) Graphics and model generation modules are supplied for building and viewing models. 4) Interface modules provide for the required data flow between IAC and other modules. 5) User modules can be arbitrary executable programs or JCL procedures with no pre-defined relationship to IAC. 6) Special purpose modules are included, such as MIMIC (Model Integration via Mesh Interpolation Coefficients), which transforms field values from one model to another; LINK, which simplifies incorporation of user specific modules into IAC modules; and DATAPAC, the National Bureau of Standards statistical analysis package. The IAC database contains structured files which provide a common basis for communication between modules and the executive system, and can contain unstructured files such as NASTRAN checkpoint files, DISCOS plot files

  17. IAC-1.5 - INTEGRATED ANALYSIS CAPABILITY

    NASA Technical Reports Server (NTRS)

    Vos, R. G.

    1994-01-01

    The objective of the Integrated Analysis Capability (IAC) system is to provide a highly effective, interactive analysis tool for the integrated design of large structures. IAC was developed to interface programs from the fields of structures, thermodynamics, controls, and system dynamics with an executive system and a database to yield a highly efficient multi-disciplinary system. Special attention is given to user requirements such as data handling and on-line assistance with operational features, and the ability to add new modules of the user's choice at a future date. IAC contains an executive system, a database, general utilities, interfaces to various engineering programs, and a framework for building interfaces to other programs. IAC has shown itself to be effective in automating data transfer among analysis programs. The IAC system architecture is modular in design. 1) The executive module contains an input command processor, an extensive data management system, and driver code to execute the application modules. 2) Technical modules provide standalone computational capability as well as support for various solution paths or coupled analyses. 3) Graphics and model generation modules are supplied for building and viewing models. 4) Interface modules provide for the required data flow between IAC and other modules. 5) User modules can be arbitrary executable programs or JCL procedures with no pre-defined relationship to IAC. 6) Special purpose modules are included, such as MIMIC (Model Integration via Mesh Interpolation Coefficients), which transforms field values from one model to another; LINK, which simplifies incorporation of user specific modules into IAC modules; and DATAPAC, the National Bureau of Standards statistical analysis package. The IAC database contains structured files which provide a common basis for communication between modules and the executive system, and can contain unstructured files such as NASTRAN checkpoint files, DISCOS plot files

  18. A1.5 Fusion Performance

    SciTech Connect

    Amendt, P

    2011-03-31

    Analysis and radiation hydrodynamics simulations for expected high-gain fusion target performance on a demonstration 1-GWe Laser Inertial Fusion Energy (LIFE) power plant in the mid-2030s timeframe are presented. The required laser energy driver is 2.2 MJ at a 0.351-{micro}m wavelength, and a fusion target gain greater than 60 at a repetition rate of 16 Hz is the design goal for economic and commercial attractiveness. A scaling-law analysis is developed to benchmark the design parameter space for hohlraum-driven central hot-spot ignition. A suite of integrated hohlraum simulations is presented to test the modeling assumptions and provide a basis for a near-term experimental resolution of the key physics uncertainties on the National Ignition Facility (NIF). The NIF is poised to demonstrate ignition by 2012 based on the central hot spot (CHS) mode of ignition and propagating thermonuclear burn [1]. This immediate prospect underscores the imperative and timeliness of advancing inertial fusion as a carbon-free, virtually limitless source of energy by the mid-21st century to substantially offset fossil fuel technologies. To this end, an intensive effort is underway to leverage success at the NIF and to provide the foundations for a prototype 'LIFE.1' engineering test facility by {approx}2025, followed by a commercially viable 'LIFE.2' demonstration power plant operating at 1 GWe by {approx}2035. The current design goal for LIFE.2 is to accommodate {approx}2.2 MJ of laser energy (entering the high-Z radiation enclosure or 'hohlraum') at a 0.351-{micro}m wavelength operating at a repetition rate of 16 Hz and to provide a fusion target yield of 132 MJ. To achieve this design goal first requires a '0-d' analytic gain model that allows convenient exploration of parameter space and target optimization. This step is then followed by 2- and 3-dimensional radiation-hydrodynamics simulations that incorporate laser beam transport, x-ray radiation transport, atomic physics, and

  19. 5 CFR 1620.1 - Application.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... at 5 U.S.C. 8351 and 8401 through 8479) originally limited TSP eligibility to specifically named... other special features. Where necessary, this part describes those special features. The employees and employing agencies covered by this part are also governed by the other regulations in 5 CFR chapter VI...

  20. 5 CFR 1620.1 - Application.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... at 5 U.S.C. 8351 and 8401 through 8479) originally limited TSP eligibility to specifically named... other special features. Where necessary, this part describes those special features. The employees and employing agencies covered by this part are also governed by the other regulations in 5 CFR chapter VI...

  1. 5 CFR 1620.1 - Application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... at 5 U.S.C. 8351 and 8401 through 8479) originally limited TSP eligibility to specifically named... other special features. Where necessary, this part describes those special features. The employees and employing agencies covered by this part are also governed by the other regulations in 5 CFR chapter VI...

  2. 26 CFR 1.1502-5 - Estimated tax.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... returns is after August 6, 1979. For prior taxable years see 26 CFR 1.1502-5 (Revised as of April 1, 1978... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Estimated tax. 1.1502-5 Section 1.1502-5...) INCOME TAXES Consolidated Tax Liability § 1.1502-5 Estimated tax. (a) General rule—(1)...

  3. CXCL5 Promotes Prostate Cancer Progression1

    PubMed Central

    Begley, Lesa A; Kasina, Sathish; Mehra, Rohit; Adsule, Shreelekha; Admon, Andrew J; Lonigro, Robert J; Chinnaiyan, Arul M; Macoska, Jill A

    2008-01-01

    CXCL5 is a proangiogenic CXC-type chemokine that is an inflammatory mediator and a powerful attractant for granulocytic immune cells. Unlike many other chemokines, CXCL5 is secreted by both immune (neutrophil, monocyte, and macrophage) and nonimmune (epithelial, endothelial, and fibroblastic) cell types. The current study was intended to determine which of these cell types express CXCL5 in normal and malignant human prostatic tissues, whether expression levels correlated with malignancy and whether CXCL5 stimulated biologic effects consistent with a benign or malignant prostate epithelial phenotype. The results of these studies show that CXCL5 protein expression levels are concordant with prostate tumor progression, are highly associated with inflammatory infiltrate, and are frequently detected in the lumens of both benign and malignant prostate glands. Exogenous administration of CXCL5 stimulates cellular proliferation and gene transcription in both nontransformed and transformed prostate epithelial cells and induces highly aggressive prostate cancer cells to invade through synthetic basement membrane in vitro. These findings suggest that the inflammatory mediator, CXCL5, may play multiple roles in the etiology of both benign and malignant proliferative diseases in the prostate. PMID:18320069

  4. HYDRATE v1.5 OPTION OF TOUGH+ v1.5

    SciTech Connect

    Moridis, George

    2015-08-27

    HYDRATE v1.5 is a numerical code that for the simulation of the behavior of hydrate-bearing geologic systems, and represents the third update of the code since its first release [Moridis et al., 2008]. It is an option of TOUGH+ v1.5 [Moridis and Pruess, 2014], a successor to the TOUGH2 [Pruess et al., 1999, 2012] family of codes for multi-component, multiphase fluid and heat flow developed at the Lawrence Berkeley National Laboratory. HYDRATE v1.5 needs the TOUGH+ v1.5 core code in order to compile and execute. It is written in standard FORTRAN 95/2003, and can be run on any computational platform (workstation, PC, Macintosh) for which such compilers are available. By solving the coupled equations of mass and heat balance, the fully operational TOUGH+HYDRATE code can model the non-isothermal gas release, phase behavior and flow of fluids and heat under conditions typical of common natural CH4-hydrate deposits (i.e., in the permafrost and in deep ocean sediments) in complex geological media at any scale (from laboratory to reservoir) at which Darcy’s law is valid. TOUGH+HYDRATE v1.5 includes both an equilibrium and a kinetic model of hydrate formation and dissociation. The model accounts for heat and up to four mass components, i.e., water, CH4, hydrate, and water-soluble inhibitors such as salts or alcohols. These are partitioned among four possible phases (gas phase, liquid phase, ice phase and hydrate phase). Hydrate dissociation or formation, phase changes and the corresponding thermal effects are fully described, as are the effects of inhibitors. The model can describe all possible hydrate dissociation mechanisms, i.e., depressurization, thermal stimulation, salting-out effects and inhibitor-induced effects.

  5. HYDRATE v1.5 OPTION OF TOUGH+ v1.5

    2015-08-27

    HYDRATE v1.5 is a numerical code that for the simulation of the behavior of hydrate-bearing geologic systems, and represents the third update of the code since its first release [Moridis et al., 2008]. It is an option of TOUGH+ v1.5 [Moridis and Pruess, 2014], a successor to the TOUGH2 [Pruess et al., 1999, 2012] family of codes for multi-component, multiphase fluid and heat flow developed at the Lawrence Berkeley National Laboratory. HYDRATE v1.5 needs themore » TOUGH+ v1.5 core code in order to compile and execute. It is written in standard FORTRAN 95/2003, and can be run on any computational platform (workstation, PC, Macintosh) for which such compilers are available. By solving the coupled equations of mass and heat balance, the fully operational TOUGH+HYDRATE code can model the non-isothermal gas release, phase behavior and flow of fluids and heat under conditions typical of common natural CH4-hydrate deposits (i.e., in the permafrost and in deep ocean sediments) in complex geological media at any scale (from laboratory to reservoir) at which Darcy’s law is valid. TOUGH+HYDRATE v1.5 includes both an equilibrium and a kinetic model of hydrate formation and dissociation. The model accounts for heat and up to four mass components, i.e., water, CH4, hydrate, and water-soluble inhibitors such as salts or alcohols. These are partitioned among four possible phases (gas phase, liquid phase, ice phase and hydrate phase). Hydrate dissociation or formation, phase changes and the corresponding thermal effects are fully described, as are the effects of inhibitors. The model can describe all possible hydrate dissociation mechanisms, i.e., depressurization, thermal stimulation, salting-out effects and inhibitor-induced effects.« less

  6. 45 CFR 1206.1-5 - Termination.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... alleged failure to comply with any requirement stated in § 1206.1-1 may be sufficiently serious to warrant... time and place, in accordance with § 1206.1-6. In the alternative the notice shall advise the recipient of its right to request a hearing and shall fix a period of time which shall not be less than 10...

  7. 5 CFR 2500.1 - Introduction.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrative Personnel OFFICE OF ADMINISTRATION, EXECUTIVE OFFICE OF THE PRESIDENT INFORMATION SECURITY REGULATION § 2500.1 Introduction. (a) References. (1) Executive Order 12065, “National Security Information”, dated June 28, 1978. (2) Information Security Oversight Office Directive No. 1, “National...

  8. 5 CFR 2500.1 - Introduction.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrative Personnel OFFICE OF ADMINISTRATION, EXECUTIVE OFFICE OF THE PRESIDENT INFORMATION SECURITY REGULATION § 2500.1 Introduction. (a) References. (1) Executive Order 12065, “National Security Information”, dated June 28, 1978. (2) Information Security Oversight Office Directive No. 1, “National...

  9. 1 CFR 5.5 - Supplement to the Code of Federal Regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Supplement to the Code of Federal Regulations. 5.5 Section 5.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.5 Supplement to the Code of Federal Regulations. The Federal Register serves as...

  10. 1 CFR 5.5 - Supplement to the Code of Federal Regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Supplement to the Code of Federal Regulations. 5.5 Section 5.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.5 Supplement to the Code of Federal Regulations. The Federal Register serves as...

  11. 1 CFR 5.5 - Supplement to the Code of Federal Regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Supplement to the Code of Federal Regulations. 5.5 Section 5.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.5 Supplement to the Code of Federal Regulations. The Federal Register serves as...

  12. 1 CFR 5.5 - Supplement to the Code of Federal Regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Supplement to the Code of Federal Regulations. 5.5 Section 5.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.5 Supplement to the Code of Federal Regulations. The Federal Register serves as...

  13. 1 CFR 5.5 - Supplement to the Code of Federal Regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Supplement to the Code of Federal Regulations. 5.5 Section 5.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.5 Supplement to the Code of Federal Regulations. The Federal Register serves as...

  14. Degradation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by Stenotrophomonas maltophilia PB1.

    PubMed Central

    Binks, P R; Nicklin, S; Bruce, N C

    1995-01-01

    A mixed microbial culture capable of metabolizing the explosive RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) was obtained from soil enrichments under aerobic and nitrogen-limiting conditions. A bacterium, Stenotrophomonas maltophilia PB1, isolated from the culture used RDX as a sole source of nitrogen for growth. Three moles of nitrogen was used per mole of RDX, yielding a metabolite identified by mass spectroscopy and 1H nuclear magnetic resonance analysis as methylene-N-(hydroxymethyl)-hydroxylamine-N'-(hydroxymethyl)nitroamin e. The bacterium also used s-triazine as a sole source of nitrogen but not the structurally similar compounds octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine, cyanuric acid, and melamine. An inducible RDX-degrading activity was present in crude cell extracts. PMID:7747953

  15. Laura Users Manual: 5.1-41601

    NASA Technical Reports Server (NTRS)

    Mazaheri, Alireza; Gnoffo, Peter A.; Johnston, Christopher O.; Kleb, Bil

    2009-01-01

    This users manual provides in-depth information concerning installation and execution of LAURA, version 5. LAURA is a structured, multi-block, computational aerothermodynamic simulation code. Version 5 represents a major refactoring of the original Fortran 77 LAURA code toward a modular structure afforded by Fortran 95. The refactoring improved usability and maintainability by eliminating the requirement for problem-dependent re-compilations, providing more intuitive distribution of functionality, and simplifying interfaces required for multiphysics coupling. As a result, LAURA now shares gas-physics modules, MPI modules, and other low-level modules with the FUN3D unstructured-grid code. In addition to internal refactoring, several new features and capabilities have been added, e.g., a GNU-standard installation process, parallel load balancing, automatic trajectory point sequencing, free-energy minimization, and coupled ablation and flowfield radiation.

  16. 26 CFR 1.684-5 - Effective date.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Effective date. 1.684-5 Section 1.684-5 Internal... TAXES (CONTINUED) Miscellaneous § 1.684-5 Effective date. Sections 1.684-1 through 1.684-4 apply to transfers of property to foreign trusts and foreign estates after August 7, 2000. income in respect...

  17. 26 CFR 1.684-5 - Effective date.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Effective date. 1.684-5 Section 1.684-5 Internal... TAXES Miscellaneous § 1.684-5 Effective date. Sections 1.684-1 through 1.684-4 apply to transfers of property to foreign trusts and foreign estates after August 7, 2000. income in respect of decedents...

  18. 26 CFR 1.181-5 - Examples.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... incurs production costs in year 1, but does not commence principal photography for film ABC until year 2.... In year 2, X begins, but does not complete, principal photography for film ABC. Most of the...

  19. 26 CFR 1.181-5 - Examples.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... incurs production costs in year 1, but does not commence principal photography for film ABC until year 2.... In year 2, X begins, but does not complete, principal photography for film ABC. Most of the...

  20. 26 CFR 1.181-5 - Examples.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... incurs production costs in year 1, but does not commence principal photography for film ABC until year 2.... In year 2, X begins, but does not complete, principal photography for film ABC. Most of the...

  1. Broadband Planar 5:1 Impedence Transformer

    NASA Technical Reports Server (NTRS)

    Ehsan, Negar; Hsieh, Wen-Ting; Moseley, Samuel H.; Wollack, Edward J.

    2015-01-01

    This paper presents a broadband Guanella-type planar impedance transformer that transforms so 50 omega to 10 omega with a 10 dB bandwidth of 1-14GHz. The transformer is designed on a flexible 50 micrometer thick polyimide substrate in microstrip and parallel-plate transmission line topologies, and is Inspired by the traditional 4:1 Guanella transformer. Back-to-back transformers were designed and fabricated for characterization in a 50 omega system. Simulated and measured results are in excellent agreement.

  2. The Learning System. Volume 5, Number 1

    ERIC Educational Resources Information Center

    von Frank, Valerie, Ed.

    2009-01-01

    "The Learning System" is an eight-page newsletter published eight times a year. Designed for superintendents and central office staff with professional learning responsibilities. This issue includes: (1) Superintendent Stays on Course with Personal Learning Plan (Valerie von Frank); (2) District Leadership: Permit, Don't Proscribe, to Build…

  3. 5 CFR 1605.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CFR 1690.1. (b) As used in this part: “As of” date means the date on which a TSP contribution or other... this date on payment records to report makeup or late contributions or late loan payments. Attributable... for which a negative adjustment is being made was a makeup or late contribution, the attributable...

  4. 5 CFR 1605.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CFR 1690.1. (b) As used in this part: “As of” date means the date on which a TSP contribution or other... this date on payment records to report makeup or late contributions or late loan payments. Attributable... makeup or late contribution, the attributable pay date is the “as of” date of the erroneous makeup...

  5. 5 CFR 1605.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CFR 1690.1. (b) As used in this part: “As of” date means the date on which a TSP contribution or other... this date on payment records to report makeup or late contributions or late loan payments. Attributable... for which a negative adjustment is being made was a makeup or late contribution, the attributable...

  6. 5 CFR 1605.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CFR 1690.1. (b) As used in this part: “As of” date means the date on which a TSP contribution or other... this date on payment records to report makeup or late contributions or late loan payments. Attributable... makeup or late contribution, the attributable pay date is the “as of” date of the erroneous makeup...

  7. 5 CFR 1605.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CFR 1690.1. (b) As used in this part: “As of” date means the date on which a TSP contribution or other... this date on payment records to report makeup or late contributions or late loan payments. Attributable... makeup or late contribution, the attributable pay date is the “as of” date of the erroneous makeup...

  8. 26 CFR 1.304-5 - Control.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... rule to extend the relevant group of persons to be tested for control of both the issuing and acquiring...(c)(2)(B) is to include in the relevant control group the person or persons that retain or acquire... transaction. Section 304(a)(1) also does not apply to A because A (or any control group of which A was...

  9. 26 CFR 1.304-5 - Control.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... rule to extend the relevant group of persons to be tested for control of both the issuing and acquiring...(c)(2)(B) is to include in the relevant control group the person or persons that retain or acquire... transaction. Section 304(a)(1) also does not apply to A because A (or any control group of which A was...

  10. 26 CFR 1.304-5 - Control.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... rule to extend the relevant group of persons to be tested for control of both the issuing and acquiring...(c)(2)(B) is to include in the relevant control group the person or persons that retain or acquire... transaction. Section 304(a)(1) also does not apply to A because A (or any control group of which A was...

  11. 1 CFR 8.5 - Ancillaries.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... date in the period covered. 1 A three volume set, “List of CFR Sections Affected, 1973-1985”, lists all... currently effective regulations in the Code of Federal Regulations. (c) List of CFR sections affected..., 1949-1963” and “List of CFR Sections Affected, 1964-1972”, list all sections of the Code which...

  12. 1 CFR 8.5 - Ancillaries.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... date in the period covered. 1 A three volume set, “List of CFR Sections Affected, 1973-1985”, lists all... currently effective regulations in the Code of Federal Regulations. (c) List of CFR sections affected..., 1949-1963” and “List of CFR Sections Affected, 1964-1972”, list all sections of the Code which...

  13. 1 CFR 8.5 - Ancillaries.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... date in the period covered. 1 A three volume set, “List of CFR Sections Affected, 1973-1985”, lists all... currently effective regulations in the Code of Federal Regulations. (c) List of CFR sections affected..., 1949-1963” and “List of CFR Sections Affected, 1964-1972”, list all sections of the Code which...

  14. 26 CFR 1.809-5 - Deductions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... nonparticipating contracts means such part of the life insurance reserves (as defined in section 801(b) and § 1.801... nonparticipating contracts (as defined in subdivision (ii) of this subparagraph). The amount of life insurance... of the increase for the taxable year in certain life insurance reserves for...

  15. Aerospace Management, Volume 5 Number 1.

    ERIC Educational Resources Information Center

    Kaprielyan, S. Peter

    Presented are articles and reports dealing with aspects of the aerospace programs of the National Aeronautics and Space Administration (NASA). Of major concern are the technological and managerial challenges within the space station and space shuttle programs. Other reports are given on: (1) medical experiments, (2) satellites, (3) international…

  16. QCD for Postgraduates (1/5)

    ScienceCinema

    None

    2016-07-12

    Modern QCD - Lecture 1 Starting from the QCD Lagrangian we will revisit some basic QCD concepts and derive fundamental properties like gauge invariance and isospin symmetry and will discuss the Feynman rules of the theory. We will then focus on the gauge group of QCD and derive the Casimirs CF and CA and some useful color identities.

  17. 43 CFR 2650.5-1 - General.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the Submerged Lands Act, of a lake less than 50 acres in size or a river or stream less than 3 chains in width did not vest in the State on the date of Statehood, such lake, river or stream shall not be... Native entitlement: (1) For any approved plat of survey where meanderable water bodies were...

  18. 43 CFR 2650.5-1 - General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the Submerged Lands Act, of a lake less than 50 acres in size or a river or stream less than 3 chains in width did not vest in the State on the date of Statehood, such lake, river or stream shall not be... Native entitlement: (1) For any approved plat of survey where meanderable water bodies were...

  19. 43 CFR 2650.5-1 - General.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the Submerged Lands Act, of a lake less than 50 acres in size or a river or stream less than 3 chains in width did not vest in the State on the date of Statehood, such lake, river or stream shall not be... Native entitlement: (1) For any approved plat of survey where meanderable water bodies were...

  20. 1 CFR 8.5 - Ancillaries.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... date in the period covered. 1 A three volume set, “List of CFR Sections Affected, 1973-1985”, lists all... currently effective regulations in the Code of Federal Regulations. (c) List of CFR sections affected..., 1949-1963” and “List of CFR Sections Affected, 1964-1972”, list all sections of the Code which...

  1. 1 CFR 8.5 - Ancillaries.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... date in the period covered. 1 A three volume set, “List of CFR Sections Affected, 1973-1985”, lists all... currently effective regulations in the Code of Federal Regulations. (c) List of CFR sections affected..., 1949-1963” and “List of CFR Sections Affected, 1964-1972”, list all sections of the Code which...

  2. 26 CFR 1.47-5 - Estates and trusts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Estates and trusts. 1.47-5 Section 1.47-5... Computing Credit for Investment in Certain Depreciable Property § 1.47-5 Estates and trusts. (a) In general—(1) Disposition or cessation in hands of estate or trust. If an estate or trust disposes of...

  3. Kcnq1-5 (Kv7.1-5) potassium channel expression in the adult zebrafish

    PubMed Central

    2014-01-01

    Background KCNQx genes encode slowly activating-inactivating K+ channels, are linked to physiological signal transduction pathways, and mutations in them underlie diseases such as long QT syndrome (KCNQ1), epilepsy in adults (KCNQ2/3), benign familial neonatal convulsions in children (KCNQ3), and hearing loss or tinnitus in humans (KCNQ4, but not KCNQ5). Identification of kcnqx potassium channel transcripts in zebrafish (Danio rerio) remains to be fully characterized although some genes have been mapped to the genome. Using zebrafish genome resources as the source of putative kcnq sequences, we investigated the expression of kcnq1-5 in heart, brain and ear tissues. Results Overall expression of the kcnqx channel transcripts is similar to that found in mammals. We found that kcnq1 expression was highest in the heart, and also present in the ear and brain. kcnq2 was lowest in the heart, while kcnq3 was highly expressed in the brain, heart and ear. kcnq5 expression was highest in the ear. We analyzed zebrafish genomic clones containing putative kcnq4 sequences to identify transcripts and protein for this highly conserved member of the Kcnq channel family. The zebrafish appears to have two kcnq4 genes that produce distinct mRNA species in brain, ear, and heart tissues. Conclusions We conclude that the zebrafish is an attractive model for the study of the KCNQ (Kv7) superfamily of genes, and are important to processes involved in neuronal excitability, cardiac anomalies, epileptic seizures, and hearing loss or tinnitus. PMID:24555524

  4. 26 CFR 1.409A-5 - Funding. [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 5 2012-04-01 2011-04-01 true Funding. 1.409A-5 Section 1.409A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.409A-5 Funding....

  5. 26 CFR 1.409A-5 - Funding. [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 5 2011-04-01 2011-04-01 false Funding. 1.409A-5 Section 1.409A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.409A-5 Funding....

  6. 26 CFR 1.409A-5 - Funding. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Funding. 1.409A-5 Section 1.409A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.409A-5 Funding....

  7. 26 CFR 1.409A-5 - Funding. [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 5 2013-04-01 2013-04-01 false Funding. 1.409A-5 Section 1.409A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.409A-5 Funding....

  8. 26 CFR 1.409A-5 - Funding. [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 5 2014-04-01 2014-04-01 false Funding. 1.409A-5 Section 1.409A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.409A-5 Funding....

  9. Chemiluminescent determination of 1,3-dibromo-5,5-dimethylhydantoin and 1,3-dichloro-5,5-dimethylhydantoin in water and in air

    SciTech Connect

    Pilipenko, A.T.; Zui, O.V.; Terletskaya, A.V.

    1986-10-10

    It was found that 1,3-dichloro-5,5-dimethylhydantoin (DCDH) and 1,3-dibromo-5,5-dimethyl-hydantoin (DBDH) react with luminol in aqueous solutions and in organic solvents giving luminous radiation. The optimal conditions for the reaction have been found. A chemiluminescent method was developed for the determination of micro-quantities of DCDH and DBDH in aqueous solutions with detection limits of 0.2 and 4 ng/ml, respectively. The method was used for the analysis of the DBDH content in water and in air in production premises.

  10. Fragrance material review on 1-(5,5-dimethylcyclohexen-1-yl)pent-4-en-1-one.

    PubMed

    Scognamiglio, J; Letizia, C S; Api, A M

    2013-12-01

    A toxicologic and dermatologic review of 1-(5,5-dimethylcyclohexen-1-yl)pent-4-en-1-one when used as a fragrance ingredient is presented. 1-(5,5-Dimethylcyclohexen-1-yl)pent-4-en-1-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all published and unpublished toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1-(5,5-dimethylcyclohexen-1-yl)pent-4-en-1-one were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, and photoallergy data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A Toxicologic and Dermatologic Assessment of Alkyl Cyclic Ketones When Used as Fragrance Ingredients (submitted for publication)) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances.

  11. Water quality criteria for hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX).

    PubMed

    Etnier, E L

    1989-04-01

    The occurrence of the munitions compound hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in groundwater surrounding Army ammunition plants may result in contamination of local drinking water supplies. RDX exerts its primary toxic effect in humans on the central nervous system, but also involves gastrointestinal and renal effects. Symptomatic effects following acute exposure include hyperirritability, nausea, vomiting, generalized epileptiform seizures, and prolonged postictal confusion and amnesia. Health effects data were analyzed for RDX, and although no controlled human studies exist concerning the acute or chronic toxic effects of exposure to RDX, sufficient animal toxicity data are available to derive an ambient water quality criterion for the protection of human health. This paper summarizes the available literature on metabolism of RDX and human and animal toxicity. Based on noncarcinogenic mammalian toxicity data, and following the methodologies of the U.S. Environmental Protection Agency, an ambient water quality criterion for the protection of human health of 103 micrograms/liter is proposed for ingestion of drinking water and aquatic foodstuffs. A criterion of 105 micrograms/liter is proposed for ingestion of drinking water alone.

  12. Water quality criteria for hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

    SciTech Connect

    Etnier, E.L.

    1989-04-01

    The occurrence of the munitions compound hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in groundwater surrounding Army ammunition plants may result in contamination of local drinking water supplies. RDX exerts its primary toxic effect in humans on the central nervous system, but also involves gastrointestinal and renal effects. Symptomatic effects following acute exposure include hyperirritability, nausea, vomiting, generalized epileptiform seizures, and prolonged postictal confusion and amnesia. Health effects data were analyzed for RDX, and although no controlled human studies exist concerning the acute or chronic toxic effects of exposure to RDX, sufficient animal toxicity data are available to derive an ambient water quality criterion for the protection of human health. This paper summarizes the available literature on metabolism of RDX and human and animal toxicity. Based on noncarcinogenic mammalian toxicity data, and following the methodologies of the U.S. Environmental Protection Agency, an ambient water quality criterion for the protection of human health of 103 micrograms/liter is proposed for ingestion of drinking water and aquatic foodstuffs. A criterion of 105 micrograms/liter is proposed for ingestion of drinking water alone.54 references.

  13. 1-Methyl-5-nitro-1H-imidazole

    PubMed Central

    Diao, Ying; Wang, Wen-Yan; Wei, Zhi-Hua; Wang, Jian-Long

    2011-01-01

    In the title compound, C4H5N3O2, the nitro group is twisted with respect to the imidazole ring by a dihedral angle of 5.60 (2)°. Weak inter­molecular C—H⋯O and C—H⋯N hydrogen bonding is present in the crystal structure. PMID:22220080

  14. TAE+ 5.1 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.1 (SUN3 VERSION)

    NASA Technical Reports Server (NTRS)

    TAE SUPPORT OFFICE

    1994-01-01

    workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. The Silicon Graphics version of TAE Plus now has a font caching scheme and a color caching scheme to make color allocation more efficient. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides an extremely powerful means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System, Version 11 Release 4, and the Open Software Foundation's Motif Toolkit 1.1 or 1.1.1. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus comes with InterViews and idraw, two software packages developed by Stanford University and integrated in TAE Plus. TAE Plus was developed in 1989 and version 5.1 was released in 1991. TAE Plus is currently available on media suitable for eight different machine platforms: 1) DEC VAX computers running VMS 5.3 or higher (TK

  15. TAE+ 5.1 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.1 (DEC VAX ULTRIX VERSION)

    NASA Technical Reports Server (NTRS)

    TAE SUPPORT OFFICE

    1994-01-01

    workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. The Silicon Graphics version of TAE Plus now has a font caching scheme and a color caching scheme to make color allocation more efficient. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides an extremely powerful means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System, Version 11 Release 4, and the Open Software Foundation's Motif Toolkit 1.1 or 1.1.1. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus comes with InterViews and idraw, two software packages developed by Stanford University and integrated in TAE Plus. TAE Plus was developed in 1989 and version 5.1 was released in 1991. TAE Plus is currently available on media suitable for eight different machine platforms: 1) DEC VAX computers running VMS 5.3 or higher (TK

  16. 26 CFR 1.243-5 - Effect of election.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Effect of election. 1.243-5 Section 1.243-5...) INCOME TAXES Special Deductions for Corporations § 1.243-5 Effect of election. (a) General—(1) Corporations subject to restrictions and limitations. If an election by an affiliated group under section...

  17. 26 CFR 1.243-5 - Effect of election.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 3 2011-04-01 2011-04-01 false Effect of election. 1.243-5 Section 1.243-5...) INCOME TAXES (CONTINUED) Special Deductions for Corporations § 1.243-5 Effect of election. (a) General—(1) Corporations subject to restrictions and limitations. If an election by an affiliated group under section...

  18. 26 CFR 1.243-5 - Effect of election.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 3 2012-04-01 2012-04-01 false Effect of election. 1.243-5 Section 1.243-5...) INCOME TAXES (CONTINUED) Special Deductions for Corporations § 1.243-5 Effect of election. (a) General—(1) Corporations subject to restrictions and limitations. If an election by an affiliated group under section...

  19. 26 CFR 1.243-5 - Effect of election.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 3 2014-04-01 2014-04-01 false Effect of election. 1.243-5 Section 1.243-5...) INCOME TAXES (CONTINUED) Special Deductions for Corporations § 1.243-5 Effect of election. (a) General—(1) Corporations subject to restrictions and limitations. If an election by an affiliated group under section...

  20. 28 CFR 1.5 - Disclosure of files.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Disclosure of files. 1.5 Section 1.5 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.5 Disclosure of files. Petitions, reports, memoranda, and communications submitted or furnished in connection with the consideration of...

  1. 26 CFR 1.56A-5 - Tax carryovers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 1 2013-04-01 2013-04-01 false Tax carryovers. 1.56A-5 Section 1.56A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Regulations Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56A-5 Tax carryovers. (a) In...

  2. 26 CFR 1.56A-5 - Tax carryovers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Tax carryovers. 1.56A-5 Section 1.56A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Regulations Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56A-5 Tax carryovers. (a) In...

  3. 26 CFR 1.56A-5 - Tax carryovers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 1 2014-04-01 2013-04-01 true Tax carryovers. 1.56A-5 Section 1.56A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Regulations Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56A-5 Tax carryovers. (a) In...

  4. 26 CFR 1.56A-5 - Tax carryovers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 1 2012-04-01 2012-04-01 false Tax carryovers. 1.56A-5 Section 1.56A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Regulations Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56A-5 Tax carryovers. (a) In...

  5. 7 CFR 1.5 - Requests for records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Requests for records. 1.5 Section 1.5 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.5 Requests for... in the Office of Communications, U.S. Department of Agriculture, Washington, DC 20250. (f)...

  6. 26 CFR 1.166-5 - Nonbusiness debts.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Nonbusiness debts. 1.166-5 Section 1.166-5...) INCOME TAXES (CONTINUED) Itemized Deductions for Individuals and Corporations § 1.166-5 Nonbusiness debts. (a) Allowance of deduction as capital loss. (1) The loss resulting from any nonbusiness...

  7. 26 CFR 1.166-5 - Nonbusiness debts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Nonbusiness debts. 1.166-5 Section 1.166-5...) INCOME TAXES (CONTINUED) Itemized Deductions for Individuals and Corporations § 1.166-5 Nonbusiness debts. (a) Allowance of deduction as capital loss. (1) The loss resulting from any nonbusiness...

  8. 26 CFR 1.469-5 - Material participation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false Material participation. 1.469-5 Section 1.469-5...) INCOME TAXES Taxable Year for Which Deductions Taken § 1.469-5 Material participation. (a)-(e) (f... taxpayer. (i) (j) Material participation for preceding taxable years—(1) In general. For purposes of §...

  9. 7 CFR 1.5 - Requests for records.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Requests for records. 1.5 Section 1.5 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.5 Requests for... in the Office of Communications, U.S. Department of Agriculture, Washington, DC 20250. (f)...

  10. 7 CFR 1a.5 - Responsibility of the Inspector General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Responsibility of the Inspector General. 1a.5 Section 1a.5 Agriculture Office of the Secretary of Agriculture LAW ENFORCEMENT AUTHORITIES § 1a.5 Responsibility of the Inspector General. The Inspector General shall: (a) Issue directives conforming to...

  11. 26 CFR 1.56A-5 - Tax carryovers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Tax carryovers. 1.56A-5 Section 1.56A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Regulations Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56A-5 Tax carryovers. (a) In...

  12. 26 CFR 1.132-5 - Working condition fringes.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Working condition fringes. 1.132-5 Section 1.132-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Excluded from Gross Income § 1.132-5 Working condition fringes. (a) In general—(1)...

  13. 26 CFR 1.469-5 - Material participation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 6 2013-04-01 2013-04-01 false Material participation. 1.469-5 Section 1.469-5...) INCOME TAXES (CONTINUED) Taxable Year for Which Deductions Taken § 1.469-5 Material participation. (a)-(e... year of the taxpayer. (i) (j) Material participation for preceding taxable years—(1) In general....

  14. 26 CFR 1.469-5 - Material participation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 6 2012-04-01 2012-04-01 false Material participation. 1.469-5 Section 1.469-5...) INCOME TAXES (CONTINUED) Taxable Year for Which Deductions Taken § 1.469-5 Material participation. (a)-(e... year of the taxpayer. (i) (j) Material participation for preceding taxable years—(1) In general....

  15. 26 CFR 1.469-5 - Material participation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 6 2011-04-01 2011-04-01 false Material participation. 1.469-5 Section 1.469-5...) INCOME TAXES (CONTINUED) Taxable Year for Which Deductions Taken § 1.469-5 Material participation. (a)-(e... year of the taxpayer. (i) (j) Material participation for preceding taxable years—(1) In general....

  16. Generation 1.5 Written Error Patterns: A Comparative Study

    ERIC Educational Resources Information Center

    Doolan, Stephen M.; Miller, Donald

    2012-01-01

    In an attempt to contribute to existing research on Generation 1.5 students, the current study uses quantitative and qualitative methods to compare error patterns in a corpus of Generation 1.5, L1, and L2 community college student writing. This error analysis provides one important way to determine if error patterns in Generation 1.5 student…

  17. 18 CFR 250.1-250.5 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false 250.1-250.5 Section 250.1-250.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY APPROVED FORMS, NATURAL GAS ACT FORMS §§ 250.1-250.5...

  18. 18 CFR 250.1-250.5 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false 250.1-250.5 Section 250.1-250.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY APPROVED FORMS, NATURAL GAS ACT FORMS §§ 250.1—250.5...

  19. 18 CFR 250.1-250.5 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false 250.1-250.5 Section 250.1-250.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY APPROVED FORMS, NATURAL GAS ACT FORMS §§ 250.1-250.5...

  20. 18 CFR 250.1-250.5 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false 250.1-250.5 Section 250.1-250.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY APPROVED FORMS, NATURAL GAS ACT FORMS §§ 250.1—250.5...

  1. 18 CFR 250.1-250.5 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false 250.1-250.5 Section 250.1-250.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY APPROVED FORMS, NATURAL GAS ACT FORMS §§ 250.1-250.5...

  2. Interaction between 5-HT(1A) and 5-HT(1B) receptors: effects of 8-OH-DPAT-induced hypothermia in 5-HT(1B) receptor knockout mice.

    PubMed

    Gardier, A M; Gruwez, B; Trillat, A C; Jacquot, C; Hen, R; Bourin, M

    2001-06-15

    To test for adaptive compensatory changes that may have occurred in the functional activity of somatodendritic 5-HT(1A) receptors during the development of constitutive "knockout" mice lacking the 5-HT(1B) receptor subtype (5-HT(1B) -/- KO), we assayed for decrease in body temperature induced by an acute subcutaneous injection of the 5-HT(1A) receptor agonist, 8-hydroxy 2(di-n-propyl(amino)tetralin (8-OH-DPAT), either alone or in the presence of a selective 5-HT(1A) receptor antagonist, N-[4-(2-methoxyphenyl)-1-piperazinyl]-N-(2-pyridinyl) cyclo-hexanecarboxamide (WAY 100635). We compared dose-response curves, time course study, calculated ED(50) values (potency), maximal response to 8-OH-DPAT (efficacy) as well as measurements of the dose-dependent blockade of this response by WAY 100635 between wild-type controls and mutant mice. We found a higher efficacy of 8-OH-DPAT-induced hypothermia in 5-HT(1B) -/- KO compared to wild-type mice suggesting that an adaptive thermoregulatory process involving the functional activity of somatodendritic 5-HT(1A) receptors is altered in mutant mice lacking 5-HT(1B) receptors.

  3. 26 CFR 1.642(h)-5 - Example.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Example. 1.642(h)-5 Section 1.642(h)-5 Internal... TAXES Estates, Trusts, and Beneficiaries § 1.642(h)-5 Example. The application of section 642(h) may be... deductions 14,800 It also has a capital loss of $5,000. (b) Under section 642(h)(1), an unused net...

  4. 33 CFR 1.26-5 - Replacement of medals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... 937; 14 U.S.C. 501, 633; 49 U.S.C. 1655(b)(1); 49 CFR 1.46(b)) ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Replacement of medals. 1.26-5 Section 1.26-5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY...

  5. 26 CFR 1.9000-5 - Effect of filing statement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Effect of filing statement. 1.9000-5 Section 1.9000-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES General Actuarial Valuations § 1.9000-5 Effect of filing statement. (a) Years...

  6. 41 CFR 128-1.5002-5 - Personal property.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Personal property. 128-1.5002-5 Section 128-1.5002-5 Public Contracts and Property Management Federal Property Management... Personal Property Management § 128-1.5002-5 Personal property. Property of any kind or interest...

  7. 40 CFR 205.5-1 - Testing exemption.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Testing exemption. 205.5-1 Section 205.5-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS General Provisions § 205.5-1 Testing exemption. (a) A...

  8. 40 CFR 205.5-1 - Testing exemption.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Testing exemption. 205.5-1 Section 205.5-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS General Provisions § 205.5-1 Testing exemption. (a) A...

  9. 40 CFR 205.5-1 - Testing exemption.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Testing exemption. 205.5-1 Section 205.5-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS General Provisions § 205.5-1 Testing exemption. (a) A...

  10. 40 CFR 205.5-1 - Testing exemption.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Testing exemption. 205.5-1 Section 205.5-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS General Provisions § 205.5-1 Testing exemption. (a) A...

  11. 40 CFR 205.5-1 - Testing exemption.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Testing exemption. 205.5-1 Section 205.5-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS General Provisions § 205.5-1 Testing exemption. (a) A...

  12. 43 CFR 3802.1-5 - Plan approval.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Plan approval. 3802.1-5 Section 3802.1-5... and Mining, Wilderness Review Program § 3802.1-5 Plan approval. (a) The authorized officer shall promptly aknowledge the receipt of a plan of operations and within 30 days of receipt of the plan act...

  13. 43 CFR 3802.1-5 - Plan approval.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Plan approval. 3802.1-5 Section 3802.1-5... and Mining, Wilderness Review Program § 3802.1-5 Plan approval. (a) The authorized officer shall promptly aknowledge the receipt of a plan of operations and within 30 days of receipt of the plan act...

  14. 43 CFR 3802.1-5 - Plan approval.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Plan approval. 3802.1-5 Section 3802.1-5... and Mining, Wilderness Review Program § 3802.1-5 Plan approval. (a) The authorized officer shall promptly aknowledge the receipt of a plan of operations and within 30 days of receipt of the plan act...

  15. 26 CFR 1.818-5 - Short taxable years.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Short taxable years. 1.818-5 Section 1.818-5...) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.818-5 Short taxable years. (a) In general. Section... Code, is for a period of less than the entire calendar year, then section 443 (relating to returns...

  16. 26 CFR 1.818-5 - Short taxable years.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 8 2014-04-01 2014-04-01 false Short taxable years. 1.818-5 Section 1.818-5...) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.818-5 Short taxable years. (a) In general. Section... Code, is for a period of less than the entire calendar year, then section 443 (relating to returns...

  17. 26 CFR 1.818-5 - Short taxable years.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 8 2012-04-01 2012-04-01 false Short taxable years. 1.818-5 Section 1.818-5...) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.818-5 Short taxable years. (a) In general. Section... Code, is for a period of less than the entire calendar year, then section 443 (relating to returns...

  18. 26 CFR 1.472-5 - Revocation of election.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 6 2014-04-01 2014-04-01 false Revocation of election. 1.472-5 Section 1.472-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Inventories § 1.472-5 Revocation of election. An election made to adopt and...

  19. 26 CFR 1.472-5 - Revocation of election.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 6 2011-04-01 2011-04-01 false Revocation of election. 1.472-5 Section 1.472-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Inventories § 1.472-5 Revocation of election. An election made to adopt and...

  20. 26 CFR 1.1502-5 - Estimated tax.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) for filing returns is after August 6, 1979. For prior taxable years see 26 CFR 1.1502-5 (Revised as of... 26 Internal Revenue 12 2013-04-01 2013-04-01 false Estimated tax. 1.1502-5 Section 1.1502-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX...

  1. 26 CFR 1.1502-5 - Estimated tax.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) for filing returns is after August 6, 1979. For prior taxable years see 26 CFR 1.1502-5 (Revised as of... 26 Internal Revenue 12 2011-04-01 2011-04-01 false Estimated tax. 1.1502-5 Section 1.1502-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX...

  2. 26 CFR 1.1502-5 - Estimated tax.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) for filing returns is after August 6, 1979. For prior taxable years see 26 CFR 1.1502-5 (Revised as of... 26 Internal Revenue 12 2012-04-01 2012-04-01 false Estimated tax. 1.1502-5 Section 1.1502-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX...

  3. 26 CFR 1.1502-5 - Estimated tax.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) for filing returns is after August 6, 1979. For prior taxable years see 26 CFR 1.1502-5 (Revised as of... 26 Internal Revenue 12 2014-04-01 2014-04-01 false Estimated tax. 1.1502-5 Section 1.1502-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX...

  4. 26 CFR 1.544-5 - Convertible securities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 7 2011-04-01 2009-04-01 true Convertible securities. 1.544-5 Section 1.544-5...) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.544-5 Convertible securities. Under section 544(b) outstanding securities of a corporation such as bonds, debentures, or other corporate obligations,...

  5. 26 CFR 1.446-5 - Debt issuance costs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 6 2011-04-01 2011-04-01 false Debt issuance costs. 1.446-5 Section 1.446-5...) INCOME TAXES (CONTINUED) Methods of Accounting § 1.446-5 Debt issuance costs. (a) In general. This section provides rules for allocating debt issuance costs over the term of the debt. For purposes of...

  6. 26 CFR 1.446-5 - Debt issuance costs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false Debt issuance costs. 1.446-5 Section 1.446-5...) INCOME TAXES Methods of Accounting § 1.446-5 Debt issuance costs. (a) In general. This section provides rules for allocating debt issuance costs over the term of the debt. For purposes of this section,...

  7. 45 CFR 1211.1-5 - Matters not covered.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Matters not covered. 1211.1-5 Section 1211.1-5... SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-5 Matters not covered. Matters not within the definition... following are specific examples of excluded areas and are not intended as a complete listing of the...

  8. 45 CFR 1211.1-5 - Matters not covered.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Matters not covered. 1211.1-5 Section 1211.1-5... SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-5 Matters not covered. Matters not within the definition... following are specific examples of excluded areas and are not intended as a complete listing of the...

  9. 45 CFR 1211.1-5 - Matters not covered.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Matters not covered. 1211.1-5 Section 1211.1-5... SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-5 Matters not covered. Matters not within the definition... following are specific examples of excluded areas and are not intended as a complete listing of the...

  10. 45 CFR 1211.1-5 - Matters not covered.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Matters not covered. 1211.1-5 Section 1211.1-5... SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-5 Matters not covered. Matters not within the definition... following are specific examples of excluded areas and are not intended as a complete listing of the...

  11. 45 CFR 1211.1-5 - Matters not covered.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Matters not covered. 1211.1-5 Section 1211.1-5... SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-5 Matters not covered. Matters not within the definition... following are specific examples of excluded areas and are not intended as a complete listing of the...

  12. 26 CFR 1.679-5 - Pre-immigration trusts.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 8 2013-04-01 2013-04-01 false Pre-immigration trusts. 1.679-5 Section 1.679-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Grantors and Others Treated As Substantial Owners § 1.679-5...

  13. 26 CFR 1.679-5 - Pre-immigration trusts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Pre-immigration trusts. 1.679-5 Section 1.679-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Grantors and Others Treated As Substantial Owners § 1.679-5 Pre-immigration trusts. (a)...

  14. 26 CFR 1.679-5 - Pre-immigration trusts.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Pre-immigration trusts. 1.679-5 Section 1.679-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Grantors and Others Treated As Substantial Owners § 1.679-5...

  15. 26 CFR 1.679-5 - Pre-immigration trusts.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 8 2014-04-01 2014-04-01 false Pre-immigration trusts. 1.679-5 Section 1.679-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Grantors and Others Treated As Substantial Owners § 1.679-5...

  16. 26 CFR 1.679-5 - Pre-immigration trusts.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 8 2012-04-01 2012-04-01 false Pre-immigration trusts. 1.679-5 Section 1.679-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Grantors and Others Treated As Substantial Owners § 1.679-5...

  17. 26 CFR 303.1-5 - Payment of taxes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Payment of taxes. 303.1-5 Section 303.1-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION TAXES UNDER THE TRADING WITH THE ENEMY ACT § 303.1-5 Payment of taxes. (a) Pursuant to...

  18. 26 CFR 1.528-5 - Source of income test.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 7 2012-04-01 2012-04-01 false Source of income test. 1.528-5 Section 1.528-5...) INCOME TAXES (CONTINUED) Homeowners Associations § 1.528-5 Source of income test. An organization cannot... of whether an organization meets the provisions of this section shall be made after the close of...

  19. 26 CFR 1.528-5 - Source of income test.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 7 2011-04-01 2009-04-01 true Source of income test. 1.528-5 Section 1.528-5...) INCOME TAXES (CONTINUED) Homeowners Associations § 1.528-5 Source of income test. An organization cannot... of whether an organization meets the provisions of this section shall be made after the close of...

  20. 26 CFR 1.528-5 - Source of income test.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 7 2013-04-01 2013-04-01 false Source of income test. 1.528-5 Section 1.528-5...) INCOME TAXES (CONTINUED) Homeowners Associations § 1.528-5 Source of income test. An organization cannot... of whether an organization meets the provisions of this section shall be made after the close of...

  1. 26 CFR 1.528-5 - Source of income test.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Source of income test. 1.528-5 Section 1.528-5...) INCOME TAXES (CONTINUED) Homeowners Associations § 1.528-5 Source of income test. An organization cannot... of whether an organization meets the provisions of this section shall be made after the close of...

  2. 26 CFR 1.528-5 - Source of income test.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 7 2014-04-01 2013-04-01 true Source of income test. 1.528-5 Section 1.528-5...) INCOME TAXES (CONTINUED) Homeowners Associations § 1.528-5 Source of income test. An organization cannot... of whether an organization meets the provisions of this section shall be made after the close of...

  3. 26 CFR 1.544-5 - Convertible securities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Convertible securities. 1.544-5 Section 1.544-5...) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.544-5 Convertible securities. Under section 544(b) outstanding securities of a corporation such as bonds, debentures, or other corporate obligations,...

  4. 26 CFR 1.642(h)-5 - Example.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Example. 1.642(h)-5 Section 1.642(h)-5 Internal... TAXES (CONTINUED) Estates, Trusts, and Beneficiaries § 1.642(h)-5 Example. The application of section 642(h) may be illustrated by the following example: Example. (a) A decedent dies January 31,...

  5. 26 CFR 1.544-5 - Convertible securities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 7 2013-04-01 2013-04-01 false Convertible securities. 1.544-5 Section 1.544-5...) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.544-5 Convertible securities. Under section 544(b) outstanding securities of a corporation such as bonds, debentures, or other corporate obligations,...

  6. 26 CFR 1.544-5 - Convertible securities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 7 2012-04-01 2012-04-01 false Convertible securities. 1.544-5 Section 1.544-5...) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.544-5 Convertible securities. Under section 544(b) outstanding securities of a corporation such as bonds, debentures, or other corporate obligations,...

  7. 3-(4-Bromo-benzyl-idene)-1,5-dioxaspiro-[5.5]undecane-2,4-dione.

    PubMed

    Zeng, Wu-Lan

    2011-01-01

    The title mol-ecule, C(16)H(15)BrO(4), was prepared by the reaction of (R)-2,4-dioxo-1,5-dioxaspiro-[5.5]undecane and 4-bromo-benzaldehyde with ethanol. The 1,3-dioxane ring exhibits a distorted boat and the fused cyclo-hexane ring exhibits a chair conformation. PMID:21523094

  8. The GEOS-5 Data Assimilation System-Documentation of Versions 5.0.1, 5.1.0, and 5.2.0

    NASA Technical Reports Server (NTRS)

    Suarez, Max J.; Rienecker, M. M.; Todling, R.; Bacmeister, J.; Takacs, L.; Liu, H. C.; Gu, W.; Sienkiewicz, M.; Koster, R. D.; Gelaro, R.; Stajner, I.; Nielsen, J. E.

    2008-01-01

    This report documents the GEOS-5 global atmospheric model and data assimilation system (DAS), including the versions 5.0.1, 5.1.0, and 5.2.0, which have been implemented in products distributed for use by various NASA instrument team algorithms and ultimately for the Modem Era Retrospective analysis for Research and Applications (MERRA). The DAS is the integration of the GEOS-5 atmospheric model with the Gridpoint Statistical Interpolation (GSI) Analysis, a joint analysis system developed by the NOAA/National Centers for Environmental Prediction and the NASA/Global Modeling and Assimilation Office. The primary performance drivers for the GEOS DAS are temperature and moisture fields suitable for the EOS instrument teams, wind fields for the transport studies of the stratospheric and tropospheric chemistry communities, and climate-quality analyses to support studies of the hydrological cycle through MERRA. The GEOS-5 atmospheric model has been approved for open source release and is available from: http://opensource.gsfc.nasa.gov/projects/GEOS-5/GEOS-5.php.

  9. TAE+ 5.1 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.1 (SUN3 VERSION)

    NASA Technical Reports Server (NTRS)

    TAE SUPPORT OFFICE

    1994-01-01

    workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. The Silicon Graphics version of TAE Plus now has a font caching scheme and a color caching scheme to make color allocation more efficient. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides an extremely powerful means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System, Version 11 Release 4, and the Open Software Foundation's Motif Toolkit 1.1 or 1.1.1. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus comes with InterViews and idraw, two software packages developed by Stanford University and integrated in TAE Plus. TAE Plus was developed in 1989 and version 5.1 was released in 1991. TAE Plus is currently available on media suitable for eight different machine platforms: 1) DEC VAX computers running VMS 5.3 or higher (TK

  10. TAE+ 5.1 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.1 (DEC VAX ULTRIX VERSION)

    NASA Technical Reports Server (NTRS)

    TAE SUPPORT OFFICE

    1994-01-01

    workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. The Silicon Graphics version of TAE Plus now has a font caching scheme and a color caching scheme to make color allocation more efficient. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides an extremely powerful means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System, Version 11 Release 4, and the Open Software Foundation's Motif Toolkit 1.1 or 1.1.1. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus comes with InterViews and idraw, two software packages developed by Stanford University and integrated in TAE Plus. TAE Plus was developed in 1989 and version 5.1 was released in 1991. TAE Plus is currently available on media suitable for eight different machine platforms: 1) DEC VAX computers running VMS 5.3 or higher (TK

  11. Recombinant saphenous vein 5-HT1B receptors of the rabbit: comparative pharmacology with human 5-HT1B receptors.

    PubMed

    Wurch, T; Palmier, C; Colpaert, F C; Pauwels, P J

    1997-01-01

    1. The rabbit recombinant saphenous vein 5-hydroxytryptamine1B (r 5-HT1B) receptor stably transfected in rat C6-glial cells was characterized by measuring adenosine 3':5'-cyclic monophosphate (cycle AMP) formation upon exposure to various 5-HT receptor ligands. The effects of agonists and antagonists were compared with their effects determined previously at the human cloned 5-HT1B (h 5-HT1B) receptor under similar experimental conditions. 2. Intact C6-glial cells expressing rb HT1B receptors exhibited [3H]-5-carboxamidotryptamine (5-CT) binding sites with a Kd of 0.80 +/- 0.13 nM and a Bmax between 225 to 570 fmol mg-1 protein. The binding affinities of a series of 5-HT receptor ligands determined in a membrane preparation with [3H]-5-CT or [3H]-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-4-(-4 -pyridyl) benzamide (GR 125,743) were similar. With the exception of ketanserin, ligand affinities were comparable to those determined at the clones h 5-HT1B receptor site. 3. rb 5-HT1B receptors were negatively coupled to cyclic AMP formation upon stimulation with 5-HT agonists. Of the several 5-HT agonists tested, 5-CT was the most potent, the potency rank order being: 5-CT > 5-HT > zolmitriptan > naratriptan > rizatriptan > sumatriptan > R (+)-8-(hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). The maximal responses of these agonists were similar to those induced by 5-HT. The potency of these agonists showed a positive correlation (r2 = 0.87; P < 0.002) with their potency at the cloned h 5-HT1B receptor subtype. 4. 2'-Methyl-4-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-carboxylic acid [4-methoxy-e-(4-methyl-piperazin-1-yl)-phenyl]-amide (GR 127,935), methiothepin and ketanserin each behaved as silent, competitive antagonists at rb 5HT1B receptors; pKB values were 8.41, 8.32 and 7.05, respectively when naratriptan was used as an agonist. These estimates accorded with their binding affinities and the potencies found on 5-HT and/or sumatriptan

  12. Synthesis of optically active 5-alkoxy-6-methylcyclohex-2-en-1-ones and 4-alkoxy-5-methylcyclopent-1-enyl benzoate.

    PubMed

    Turks, Maris; Vogel, Pierre

    2009-01-01

    The reaction of (-)-(1E,3Z)-2-methyl-1-((1S)-1-phenylethoxy)penta-1,3-dien-3-ol benzoate with allyltrimethylsilane in SO2 and in the presence of a catalytic amount of Tf2NTMS gives a silyl sulfinate intermediate that furnishes (-)-(6Z,1'S,4S,5S)-5-methyl-4-(1'-phenylethoxy)octa-1,6-dien-6-yl benzoate after acidic workup. The latter undergoes ring-closing metathesis producing (-)-(2S,3S)-2-methyl-3-((1S)-1-phenylethoxy)cyclopent-5-en-1-yl benzoate. It has been converted also into the corresponding trimethylsilyl enol ether. After oxidation, an enone is obtained that undergoes ring-closing metathesis giving (-)-(5S,6S)-6-methyl-5-((1S)-1-phenylethoxy)cyclohex-2-en-1-one.

  13. Recombinant parainfluenza virus 5 expressing hemagglutinin of influenza A virus H5N1 protected mice against lethal highly pathogenic avian influenza virus H5N1 challenge.

    PubMed

    Li, Zhuo; Mooney, Alaina J; Gabbard, Jon D; Gao, Xiudan; Xu, Pei; Place, Ryan J; Hogan, Robert J; Tompkins, S Mark; He, Biao

    2013-01-01

    A safe and effective vaccine is the best way to prevent large-scale highly pathogenic avian influenza virus (HPAI) H5N1 outbreaks in the human population. The current FDA-approved H5N1 vaccine has serious limitations. A more efficacious H5N1 vaccine is urgently needed. Parainfluenza virus 5 (PIV5), a paramyxovirus, is not known to cause any illness in humans. PIV5 is an attractive vaccine vector. In our studies, a single dose of a live recombinant PIV5 expressing a hemagglutinin (HA) gene of H5N1 (rPIV5-H5) from the H5N1 subtype provided sterilizing immunity against lethal doses of HPAI H5N1 infection in mice. Furthermore, we have examined the effect of insertion of H5N1 HA at different locations within the PIV5 genome on the efficacy of a PIV5-based vaccine. Interestingly, insertion of H5N1 HA between the leader sequence, the de facto promoter of PIV5, and the first viral gene, nucleoprotein (NP), did not lead to a viable virus. Insertion of H5N1 HA between NP and the next gene, V/phosphorprotein (V/P), led to a virus that was defective in growth. We have found that insertion of H5N1 HA at the junction between the small hydrophobic (SH) gene and the hemagglutinin-neuraminidase (HN) gene gave the best immunity against HPAI H5N1 challenge: a dose as low as 1,000 PFU was sufficient to protect against lethal HPAI H5N1 challenge in mice. The work suggests that recombinant PIV5 expressing H5N1 HA has great potential as an HPAI H5N1 vaccine.

  14. Thermodynamic Database for the NdO(1.5)-YO(1.5)-YbO(1.5)-ScO(1.5)-ZrO2 System

    NASA Technical Reports Server (NTRS)

    Jacobson, Nathan S.; Copland, Evan H.; Kaufman, Larry

    2001-01-01

    A database for YO(1.5)-NdO(1.5)-YbO(1.5)-ScO(1.5)-ZrO2 for ThermoCalc (ThermoCalc AB, Stockholm, Sweden) has been developed. The basis of this work is the YO(1.5)-ZrO2 assessment by Y. Du, Z. Jin, and P. Huang, 'Thermodynamic Assessment of the ZrO2-YO(1.5) System'. Experimentally only the YO(1.5)-ZrO2 system has been well-studied. All other systems are only approximately known. The major simplification in this work is the treatment of each single cation unit as a component. The pure liquid oxides are taken as reference states and two term lattice stability descriptions are used for each of the components. The limited experimental phase diagrams are reproduced.

  15. TAE+ 5.1 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.1 (VAX VMS VERSION)

    NASA Technical Reports Server (NTRS)

    TAE SUPPORT OFFICE

    1994-01-01

    programs to display and control the user interfaces. Since the WPTs access the workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides a means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System, Version 11 Release 4, and the Open Software Foundation's Motif. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus was developed in 1989 and version 5.2 was released in 1993. TAE Plus 5.2 is expected to be available on media suitable for seven different machine platforms: 1) DEC VAX computers running VMS (TK50 cartridge in VAX BACKUP format), 2) IBM RS/6000 series workstations running AIX (.25 inch tape cartridge in UNIX tar format), 3) DEC RISC workstations running ULTRIX (TK50 cartridge in UNIX tar format), 4) HP9000 Series 300

  16. 1 CFR 5.10 - Forms of publication.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Forms of publication. 5.10 Section 5.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.10 Forms of publication. Pursuant to section 1506 of title 44, United States Code, the Administrative Committee...

  17. 1 CFR 5.3 - Publication of other documents.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication of other documents. 5.3 Section 5.3 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.3 Publication of other documents. Whenever the Director of the Federal Register considers that publication of...

  18. 1 CFR 5.7 - Delivery and mailing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Delivery and mailing. 5.7 Section 5.7 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.7 Delivery and mailing. The Government Printing Office shall distribute the Federal Register by delivery or by deposit...

  19. 1 CFR 6.5 - Indexes, digests, and guides.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Indexes, digests, and guides. 6.5 Section 6.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER INDEXES AND ANCILLARIES § 6.5 Indexes, digests, and guides. (a) The Director of the Federal Register may order...

  20. 1 CFR 5.8 - Form of citation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Form of citation. 5.8 Section 5.8 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.8 Form of citation. Without prejudice to any other form of citation, Federal Register material may be cited by...

  1. 1 CFR 5.9 - Categories of documents.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Categories of documents. 5.9 Section 5.9 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.9 Categories of documents. Each document published in the Federal Register shall be placed under one of the...

  2. 1 CFR 5.10 - Forms of publication.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Forms of publication. 5.10 Section 5.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.10 Forms of publication. Pursuant to section 1506 of title 44, United States Code, the Administrative Committee...

  3. 1 CFR 5.3 - Publication of other documents.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication of other documents. 5.3 Section 5.3 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.3 Publication of other documents. Whenever the Director of the Federal Register considers that publication of...

  4. 1 CFR 5.8 - Form of citation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Form of citation. 5.8 Section 5.8 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.8 Form of citation. Without prejudice to any other form of citation, Federal Register material may be cited by...

  5. 1 CFR 5.9 - Categories of documents.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Categories of documents. 5.9 Section 5.9 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.9 Categories of documents. Each document published in the Federal Register shall be placed under one of...

  6. 1 CFR 5.3 - Publication of other documents.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication of other documents. 5.3 Section 5.3 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.3 Publication of other documents. Whenever the Director of the Federal Register considers that publication of...

  7. 1 CFR 5.4 - Publication not authorized.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication not authorized. 5.4 Section 5.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.4 Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to...

  8. 1 CFR 6.5 - Indexes, digests, and guides.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Indexes, digests, and guides. 6.5 Section 6.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER INDEXES AND ANCILLARIES § 6.5 Indexes, digests, and guides. (a) The Director of the Federal Register may order...

  9. 1 CFR 5.7 - Delivery and mailing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Delivery and mailing. 5.7 Section 5.7 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.7 Delivery and mailing. The Government Printing Office shall distribute the Federal Register by delivery or by deposit...

  10. 1 CFR 6.5 - Indexes, digests, and guides.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Indexes, digests, and guides. 6.5 Section 6.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER INDEXES AND ANCILLARIES § 6.5 Indexes, digests, and guides. (a) The Director of the Federal Register may order...

  11. 1 CFR 5.8 - Form of citation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Form of citation. 5.8 Section 5.8 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.8 Form of citation. Without prejudice to any other form of citation, Federal Register material may be cited by...

  12. 1 CFR 5.4 - Publication not authorized.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication not authorized. 5.4 Section 5.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.4 Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to...

  13. 1 CFR 5.7 - Delivery and mailing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Delivery and mailing. 5.7 Section 5.7 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.7 Delivery and mailing. The Government Printing Office shall distribute the Federal Register by delivery or by deposit...

  14. 1 CFR 5.4 - Publication not authorized.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication not authorized. 5.4 Section 5.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.4 Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to...

  15. 1 CFR 5.9 - Categories of documents.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Categories of documents. 5.9 Section 5.9 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.9 Categories of documents. Each document published in the Federal Register shall be placed under one of the...

  16. 1 CFR 5.10 - Forms of publication.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Forms of publication. 5.10 Section 5.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.10 Forms of publication. Pursuant to section 1506 of title 44, United States Code, the Administrative Committee...

  17. 1 CFR 20.5 - Sources of information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Sources of information. 20.5 Section 20.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.5 Sources...

  18. 1 CFR 20.5 - Sources of information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Sources of information. 20.5 Section 20.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.5 Sources...

  19. 1 CFR 20.5 - Sources of information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Sources of information. 20.5 Section 20.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.5 Sources...

  20. 1 CFR 20.5 - Sources of information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Sources of information. 20.5 Section 20.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.5 Sources...

  1. 1 CFR 5.9 - Categories of documents.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Categories of documents. 5.9 Section 5.9 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.9 Categories of documents. Each document published in the Federal Register shall be placed under one of...

  2. 1 CFR 5.4 - Publication not authorized.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication not authorized. 5.4 Section 5.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.4 Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to...

  3. 1 CFR 6.5 - Indexes, digests, and guides.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Indexes, digests, and guides. 6.5 Section 6.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER INDEXES AND ANCILLARIES § 6.5 Indexes, digests, and guides. (a) The Director of the Federal Register may order...

  4. 1 CFR 5.8 - Form of citation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Form of citation. 5.8 Section 5.8 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.8 Form of citation. Without prejudice to any other form of citation, Federal Register material may be cited by...

  5. 1 CFR 5.7 - Delivery and mailing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Delivery and mailing. 5.7 Section 5.7 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.7 Delivery and mailing. The Government Printing Office shall distribute the Federal Register by delivery or by deposit...

  6. 1 CFR 5.3 - Publication of other documents.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication of other documents. 5.3 Section 5.3 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.3 Publication of other documents. Whenever the Director of the Federal Register considers that publication of...

  7. 1 CFR 5.10 - Forms of publication.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Forms of publication. 5.10 Section 5.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.10 Forms of publication. Pursuant to section 1506 of title 44, United States Code, the Administrative Committee...

  8. 1 CFR 5.7 - Delivery and mailing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Delivery and mailing. 5.7 Section 5.7 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.7 Delivery and mailing. The Government Printing Office shall distribute the Federal Register by delivery or by deposit...

  9. 1 CFR 5.8 - Form of citation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Form of citation. 5.8 Section 5.8 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.8 Form of citation. Without prejudice to any other form of citation, Federal Register material may be cited by...

  10. 1 CFR 5.9 - Categories of documents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Categories of documents. 5.9 Section 5.9 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.9 Categories of documents. Each document published in the Federal Register shall be placed under one of...

  11. 1 CFR 5.10 - Forms of publication.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Forms of publication. 5.10 Section 5.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.10 Forms of publication. Pursuant to section 1506 of title 44, United States Code, the Administrative Committee...

  12. 1 CFR 5.4 - Publication not authorized.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication not authorized. 5.4 Section 5.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.4 Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to...

  13. 1 CFR 6.5 - Indexes, digests, and guides.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Indexes, digests, and guides. 6.5 Section 6.5 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER INDEXES AND ANCILLARIES § 6.5 Indexes, digests, and guides. (a) The Director of the Federal Register may order...

  14. 1 CFR 5.3 - Publication of other documents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication of other documents. 5.3 Section 5.3 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.3 Publication of other documents. Whenever the Director of the Federal Register considers that publication of...

  15. 49 CFR 172.524 - EXPLOSIVES 1.5 placard.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false EXPLOSIVES 1.5 placard. 172.524 Section 172.524... SECURITY PLANS Placarding § 172.524 EXPLOSIVES 1.5 placard. (a) Except for size and color, the EXPLOSIVES 1... subpart, the background color on EXPLOSIVES 1.5 placard must be orange. The “*” shall be replaced,...

  16. 49 CFR 172.524 - EXPLOSIVES 1.5 placard.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false EXPLOSIVES 1.5 placard. 172.524 Section 172.524... SECURITY PLANS Placarding § 172.524 EXPLOSIVES 1.5 placard. (a) Except for size and color, the EXPLOSIVES 1... subpart, the background color on EXPLOSIVES 1.5 placard must be orange. The “*” shall be replaced,...

  17. 49 CFR 172.524 - EXPLOSIVES 1.5 placard.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false EXPLOSIVES 1.5 placard. 172.524 Section 172.524... SECURITY PLANS Placarding § 172.524 EXPLOSIVES 1.5 placard. (a) Except for size and color, the EXPLOSIVES 1... subpart, the background color on EXPLOSIVES 1.5 placard must be orange. The “*” shall be replaced,...

  18. 49 CFR 172.524 - EXPLOSIVES 1.5 placard.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false EXPLOSIVES 1.5 placard. 172.524 Section 172.524... SECURITY PLANS Placarding § 172.524 EXPLOSIVES 1.5 placard. (a) Except for size and color, the EXPLOSIVES 1... subpart, the background color on EXPLOSIVES 1.5 placard must be orange. The “*” shall be replaced,...

  19. 49 CFR 172.524 - EXPLOSIVES 1.5 placard.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false EXPLOSIVES 1.5 placard. 172.524 Section 172.524... SECURITY PLANS Placarding § 172.524 EXPLOSIVES 1.5 placard. (a) Except for size and color, the EXPLOSIVES 1... subpart, the background color on EXPLOSIVES 1.5 placard must be orange. The “*” shall be replaced,...

  20. 26 CFR 1.57-5 - Records to be kept.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Records to be kept. 1.57-5 Section 1.57-5... Preference Regulations § 1.57-5 Records to be kept. (a) In general. The taxpayer shall have available... placed in service or an estimate of the number of units to be produced by the property on the date...

  1. 26 CFR 1.57-5 - Records to be kept.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 1 2014-04-01 2013-04-01 true Records to be kept. 1.57-5 Section 1.57-5... Preference Regulations § 1.57-5 Records to be kept. (a) In general. The taxpayer shall have available... placed in service or an estimate of the number of units to be produced by the property on the date...

  2. 26 CFR 1.57-5 - Records to be kept.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 1 2012-04-01 2012-04-01 false Records to be kept. 1.57-5 Section 1.57-5... Preference Regulations § 1.57-5 Records to be kept. (a) In general. The taxpayer shall have available... placed in service or an estimate of the number of units to be produced by the property on the date...

  3. 26 CFR 1.57-5 - Records to be kept.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Records to be kept. 1.57-5 Section 1.57-5... Preference Regulations § 1.57-5 Records to be kept. (a) In general. The taxpayer shall have available... placed in service or an estimate of the number of units to be produced by the property on the date...

  4. TAE+ 5.1 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.1 (VAX VMS VERSION)

    NASA Technical Reports Server (NTRS)

    TAE SUPPORT OFFICE

    1994-01-01

    programs to display and control the user interfaces. Since the WPTs access the workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides a means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System, Version 11 Release 4, and the Open Software Foundation's Motif. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus was developed in 1989 and version 5.2 was released in 1993. TAE Plus 5.2 is expected to be available on media suitable for seven different machine platforms: 1) DEC VAX computers running VMS (TK50 cartridge in VAX BACKUP format), 2) IBM RS/6000 series workstations running AIX (.25 inch tape cartridge in UNIX tar format), 3) DEC RISC workstations running ULTRIX (TK50 cartridge in UNIX tar format), 4) HP9000 Series 300

  5. GEMPAK5. Part 1: GEMPAK5 programmer's guide, version 5.0

    NASA Technical Reports Server (NTRS)

    Desjardins, Mary L.; Brill, Keith F.; Schotz, Steven S.

    1991-01-01

    GEMPAK is a general meteorological software package used to analyze and display conventional meteorological data as well as satellite derived parameters. The Programmer's Guide describes the subroutines which can be used to build new GEMPAK programs. Part 1 contains GEMPAK subroutines.

  6. 26 CFR 1.737-5 - Effective dates.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Distributions by A Partnership § 1.737-5 Effective dates. Sections 1.737-1, 1.737-2, 1.737-3, and 1.737-4 apply to distributions by a partnership to a partner on or after January 9, 1995,...

  7. Drowsy Driving Causes 1 in 5 Fatal Crashes: Report

    MedlinePlus

    ... html Drowsy Driving Causes 1 in 5 Fatal Crashes: Report Teens and young adults, shift-workers and ... day. And, drowsy driving was a factor in crashes that claimed about 5,000 lives last year, ...

  8. 26 CFR 1.408A-5 - Recharacterized contributions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... April 1, 2003, edition of 26 CFR part 1). Q-3. What is the effect of recharacterizing a contribution... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Recharacterized contributions. 1.408A-5 Section... Recharacterized contributions. This section sets forth the following questions and answers that provide...

  9. 26 CFR 1.7872-5T - Exempted loans (temporary).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Exempted loans (temporary). 1.7872-5T Section 1... (CONTINUED) INCOME TAXES (CONTINUED) General Actuarial Valuations § 1.7872-5T Exempted loans (temporary). (a... States government; (9) Gift loans to a charitable organization (described in section 170(c)), but only...

  10. 26 CFR 1.1362-5 - Election after termination.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 11 2011-04-01 2011-04-01 false Election after termination. 1.1362-5 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Small Business Corporations and Their Shareholders § 1.1362-5 Election after termination. (a) In general. Absent the Commissioner's consent, an S corporation whose...

  11. 26 CFR 1.1362-5 - Election after termination.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 11 2013-04-01 2013-04-01 false Election after termination. 1.1362-5 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Small Business Corporations and Their Shareholders § 1.1362-5 Election after termination. (a) In general. Absent the Commissioner's consent, an S corporation whose...

  12. 26 CFR 1.1362-5 - Election after termination.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 11 2012-04-01 2012-04-01 false Election after termination. 1.1362-5 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Small Business Corporations and Their Shareholders § 1.1362-5 Election after termination. (a) In general. Absent the Commissioner's consent, an S corporation whose...

  13. 50 CFR 1.5 - Officer in Charge.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Officer in Charge. 1.5 Section 1.5 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR GENERAL... fish hatchery, national wildlife refuge, research center, or other U.S. Fish and Wildlife...

  14. 44 CFR 5.1 - Scope and purposes of part.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... disclosure of records and information held by the Federal Emergency Management Agency (FEMA) in accordance... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Scope and purposes of part. 5.1 Section 5.1 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT...

  15. 26 CFR 1.162-5 - Expenses for education.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Expenses for education. 1.162-5 Section 1.162-5... education. (a) General rule. Expenditures made by an individual for education (including research undertaken... the education may lead to a degree) if the education— (1) Maintains or improves skills required by...

  16. 26 CFR 1.162-5 - Expenses for education.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Expenses for education. 1.162-5 Section 1.162-5... education. (a) General rule. Expenditures made by an individual for education (including research undertaken... the education may lead to a degree) if the education— (1) Maintains or improves skills required by...

  17. 26 CFR 1.162-5 - Expenses for education.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Expenses for education. 1.162-5 Section 1.162-5... education. (a) General rule. Expenditures made by an individual for education (including research undertaken... the education may lead to a degree) if the education— (1) Maintains or improves skills required by...

  18. 42 CFR 5a.1 - Statutory basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Statutory basis and purpose. 5a.1 Section 5a.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS RURAL... the Public Health Service Act. These provisions define “underserved rural community” for purposes...

  19. 42 CFR 5a.1 - Statutory basis and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Statutory basis and purpose. 5a.1 Section 5a.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS RURAL... the Public Health Service Act. These provisions define “underserved rural community” for purposes...

  20. 26 CFR 1.162-5 - Expenses for education.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Expenses for education. 1.162-5 Section 1.162-5... education. (a) General rule. Expenditures made by an individual for education (including research undertaken... the education may lead to a degree) if the education— (1) Maintains or improves skills required by...

  1. 1. Historic American Buildings Survey Victor Stankiewicz, Photographer November 5, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Victor Stankiewicz, Photographer November 5, 1936. NORTH AND FRONT ELEVATIONS - Squire Michael Porter House, Jacob & Kendall Roads, Sharon Hollow, Washtenaw County, MI

  2. Propellant Containing 3, 6bis(1h-1,2,3,4-Tetrazol-5-Ylamino)-1,2,4,5- Tetrazine Or Salt Thereof

    DOEpatents

    Hiskey, Michael A.; Chavez, David E.; Naud, Darren

    2003-12-02

    The compound 3,6-bis(1H-1,2,3,4-tetrazol-5-ylamino)-1,2,4,5-tetrazine and its salts are provided together with a propellant composition including an oxidizer, a binder and 3,6-bis(1H-1,2,3,4-tetrazol-5-ylamino)-1,2,4,5-tetrazine or its salts.

  3. ERK5 MAP Kinase Regulates Neurogenin1 during Cortical Neurogenesis

    PubMed Central

    Cundiff, Paige; Liu, Lidong; Wang, Yupeng; Zou, Junhui; Pan, Yung-Wei; Abel, Glen; Duan, Xin; Ming, Guo-li; Englund, Chris; Hevner, Robert; Xia, Zhengui

    2009-01-01

    The commitment of multi-potent cortical progenitors to a neuronal fate depends on the transient induction of the basic-helix-loop-helix (bHLH) family of transcription factors including Neurogenin 1 (Neurog1). Previous studies have focused on mechanisms that control the expression of these proteins while little is known about whether their pro-neural activities can be regulated by kinase signaling pathways. Using primary cultures and ex vivo slice cultures, here we report that both the transcriptional and pro-neural activities of Neurog1 are regulated by extracellular signal-regulated kinase (ERK) 5 signaling in cortical progenitors. Activation of ERK5 potentiated, while blocking ERK5 inhibited Neurog1-induced neurogenesis. Furthermore, endogenous ERK5 activity was required for Neurog1-initiated transcription. Interestingly, ERK5 activation was sufficient to induce Neurog1 phosphorylation and ERK5 directly phosphorylated Neurog1 in vitro. We identified S179/S208 as putative ERK5 phosphorylation sites in Neurog1. Mutations of S179/S208 to alanines inhibited the transcriptional and pro-neural activities of Neurog1. Our data identify ERK5 phosphorylation of Neurog1 as a novel mechanism regulating neuronal fate commitment of cortical progenitors. PMID:19365559

  4. Short Hypocotyl in White Light1 Interacts with Elongated Hypocotyl5 (HY5) and Constitutive Photomorphogenic1 (COP1) and Promotes COP1-Mediated Degradation of HY5 during Arabidopsis Seedling Development1[OPEN

    PubMed Central

    Srivastava, Anjil Kumar; Senapati, Dhirodatta; Srivastava, Archana

    2015-01-01

    Arabidopsis (Arabidopsis thaliana) Short Hypocotyl in White Light1 (SHW1) encodes a Ser-Arg-Asp-rich protein that acts as a negative regulator of photomorphogenesis. SHW1 and Constitutive Photomorphogenic1 (COP1) genetically interact in an additive manner to suppress photomorphogenesis. Elongated Hypocotyl5 (HY5) is a photomorphogenesis promoting a basic leucine zipper transcription factor that is degraded by COP1 ubiquitin ligase in the darkness. Here, we report the functional interrelation of SHW1 with COP1 and HY5 in Arabidopsis seedling development. The in vitro and in vivo molecular interaction studies show that SHW1 physically interacts with both COP1 and HY5. The genetic studies reveal that SHW1 and HY5 work in an antagonistic manner to regulate photomorphogenic growth. Additional mutation of SHW1 in hy5 mutant background is able to suppress the gravitropic root growth defect of hy5 mutants. This study further reveals that the altered abscisic acid responsiveness of hy5 mutants is modulated by additional loss of SHW1 function. Furthermore, this study shows that SHW1 promotes COP1-mediated degradation of HY5 through enhanced ubiquitylation in the darkness. Collectively, this study highlights a mechanistic view on coordinated regulation of SHW1, COP1, and HY5 in Arabidopsis seedling development. PMID:26474641

  5. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists.

    PubMed

    Sprouse, J S; Aghajanian, G K

    1987-01-01

    A direct comparison was made of the effects of serotonin 5-HT1A and 5-HT1B selective compounds on the spontaneous firing rate of dorsal raphe serotoninergic neurons in chloral-hydrate-anesthetized rats. Following intravenous administration, the 5-HT1A selective compounds ipsapirone (TVX Q 7821) and LY 165163 potently inhibited single-unit activity in a dose-dependent manner whereas the 5-HT1B selective compounds, m-chlorophenylpiperazine (mCPP) and trifluoromethylphenylpiperazine (TFMPP), displayed only weak or irregular actions. Low microiontophoretic currents of ipsapirone and LY 165163 were also effective in suppressing spontaneous firing; dose-response relationships for the 5-HT1A compounds were indistinguishable from that of 5-HT itself. In contrast, dorsal raphe neurons were only weakly responsive to microiontophoretic application of mCPP and TFMPP; dose-response relationships for the 5-HT1B compounds were significantly displaced from that of 5-HT. In intracellular studies, ipsapirone and LY 165163, when added to the media bathing brain slices, mimicked the actions of 5-HT in hyperpolarizing dorsal raphe cell membranes and decreasing input resistance; however, the maximal effects of the 5-HT1A compounds on these membrane properties exceeded those of 5-HT. In summary, dorsal raphe 5-HT neurons appear highly responsive to 5-HT1A, but not to 5-HT1B compounds; these findings are discussed with regard to the 5-HT receptor subtypes as candidates for the somatodendritic autoreceptor of dorsal raphe neurons. PMID:3505364

  6. Thermoelectric properties of Cu-dispersed bi0.5sb1.5te3

    PubMed Central

    2012-01-01

    A novel and simple approach was used to disperse Cu nanoparticles uniformly in the Bi0.5Sb1.5Te3 matrix, and the thermoelectric properties were evaluated for the Cu-dispersed Bi0.5Sb1.5Te3. Polycrystalline Bi0.5Sb1.5Te3 powder prepared by encapsulated melting and grinding was dry-mixed with Cu(OAc)2 powder. After Cu(OAc)2 decomposition, the Cu-dispersed Bi0.5Sb1.5Te3 was hot-pressed. Cu nanoparticles were well-dispersed in the Bi0.5Sb1.5Te3 matrix and acted as effective phonon scattering centers. The electrical conductivity increased systematically with increasing level of Cu nanoparticle dispersion. All specimens had a positive Seebeck coefficient, which confirmed that the electrical charge was transported mainly by holes. The thermoelectric figure of merit was enhanced remarkably over a wide temperature range of 323-523 K. PACS: 72.15.Jf: 72.20.Pa PMID:22221588

  7. 26 CFR 1.860-5 - Effective date.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 9 2013-04-01 2013-04-01 false Effective date. 1.860-5 Section 1.860-5 Internal.... (Sec. 7805, 68A Stat. 917; 26 U.S.C. 7805; sec. 860(e) (92 Stat. 2849, 26 U.S.C. 860(e)); sec. 860(g) (92 Stat. 2850, 26 U.S.C. 860(g)))...

  8. 26 CFR 1.860-5 - Effective date.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Effective date. 1.860-5 Section 1.860-5 Internal.... (Sec. 7805, 68A Stat. 917; 26 U.S.C. 7805; sec. 860(e) (92 Stat. 2849, 26 U.S.C. 860(e)); sec. 860(g) (92 Stat. 2850, 26 U.S.C. 860(g)))...

  9. 26 CFR 1.860-5 - Effective date.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 9 2012-04-01 2012-04-01 false Effective date. 1.860-5 Section 1.860-5 Internal.... (Sec. 7805, 68A Stat. 917; 26 U.S.C. 7805; sec. 860(e) (92 Stat. 2849, 26 U.S.C. 860(e)); sec. 860(g) (92 Stat. 2850, 26 U.S.C. 860(g)))...

  10. 26 CFR 1.860-5 - Effective date.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Effective date. 1.860-5 Section 1.860-5 Internal.... (Sec. 7805, 68A Stat. 917; 26 U.S.C. 7805; sec. 860(e) (92 Stat. 2849, 26 U.S.C. 860(e)); sec. 860(g) (92 Stat. 2850, 26 U.S.C. 860(g)))...

  11. 26 CFR 1.1446-5 - Tiered partnership structures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 12 2013-04-01 2013-04-01 false Tiered partnership structures. 1.1446-5 Section... Corporations and Tax-Free Covenant Bonds § 1.1446-5 Tiered partnership structures. (a) In general. The rules of... section prescribes rules applicable to a publicly traded partnership in a tiered partnership...

  12. 26 CFR 1.1446-5 - Tiered partnership structures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 12 2012-04-01 2012-04-01 false Tiered partnership structures. 1.1446-5 Section... Corporations and Tax-Free Covenant Bonds § 1.1446-5 Tiered partnership structures. (a) In general. The rules of... section prescribes rules applicable to a publicly traded partnership in a tiered partnership...

  13. 26 CFR 1.1446-5 - Tiered partnership structures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 12 2011-04-01 2011-04-01 false Tiered partnership structures. 1.1446-5 Section... Corporations and Tax-Free Covenant Bonds § 1.1446-5 Tiered partnership structures. (a) In general. The rules of... section prescribes rules applicable to a publicly traded partnership in a tiered partnership...

  14. 40 CFR 204.5-1 - Testing exemption.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Testing exemption. 204.5-1 Section 204.5-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS...) A new product intended to be used solely for research, investigations, studies, demonstrations...

  15. 10 CFR 960.5-1 - System guidelines.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false System guidelines. 960.5-1 Section 960.5-1 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE... the applicable safety requirements set forth in 10 CFR part 20, 10 CFR part 60, and 40 CFR...

  16. 43 CFR 3162.5-1 - Environmental obligations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Environmental obligations. 3162.5-1... for Operating Rights Owners and Operators § 3162.5-1 Environmental obligations. (a) The operator shall... environmental quality. In that respect, the operator shall comply with the pertinent orders of the...

  17. 26 CFR 1.1446-5 - Tiered partnership structures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Tiered partnership structures. 1.1446-5 Section...-Free Covenant Bonds § 1.1446-5 Tiered partnership structures. (a) In general. The rules of this section... prescribes rules applicable to a publicly traded partnership in a tiered partnership structure. Paragraph...

  18. 26 CFR 1.6655-5 - Short taxable year.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 13 2011-04-01 2011-04-01 false Short taxable year. 1.6655-5 Section 1.6655-5... Short taxable year. (a) In general. Except as otherwise provided in this section, the provisions of section 6655 and these regulations are applicable in the case of a short taxable year (including...

  19. 26 CFR 1.6655-5 - Short taxable year.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Short taxable year. 1.6655-5 Section 1.6655-5... Short taxable year. (a) In general. Except as otherwise provided in this section, the provisions of section 6655 and these regulations are applicable in the case of a short taxable year (including...

  20. 26 CFR 1.6655-5 - Short taxable year.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Short taxable year. 1.6655-5 Section 1.6655-5... Short taxable year. (a) In general. Except as otherwise provided in this section, the provisions of section 6655 and these regulations are applicable in the case of a short taxable year (including...

  1. 26 CFR 1.6655-5 - Short taxable year.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Short taxable year. 1.6655-5 Section 1.6655-5... Short taxable year. (a) In general. Except as otherwise provided in this section, the provisions of section 6655 and these regulations are applicable in the case of a short taxable year (including...

  2. 43 CFR 3101.5-1 - Wildlife refuge lands.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Wildlife refuge lands. 3101.5-1 Section... § 3101.5-1 Wildlife refuge lands. (a) Wildlife refuge lands are those lands embraced in a withdrawal of.... (b) No offers for oil and gas leases covering wildlife refuge lands shall be accepted and no...

  3. 43 CFR 3101.5-1 - Wildlife refuge lands.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Wildlife refuge lands. 3101.5-1 Section... § 3101.5-1 Wildlife refuge lands. (a) Wildlife refuge lands are those lands embraced in a withdrawal of.... (b) No offers for oil and gas leases covering wildlife refuge lands shall be accepted and no...

  4. 43 CFR 3101.5-1 - Wildlife refuge lands.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Wildlife refuge lands. 3101.5-1 Section... § 3101.5-1 Wildlife refuge lands. (a) Wildlife refuge lands are those lands embraced in a withdrawal of.... (b) No offers for oil and gas leases covering wildlife refuge lands shall be accepted and no...

  5. 43 CFR 3101.5-1 - Wildlife refuge lands.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Wildlife refuge lands. 3101.5-1 Section... § 3101.5-1 Wildlife refuge lands. (a) Wildlife refuge lands are those lands embraced in a withdrawal of.... (b) No offers for oil and gas leases covering wildlife refuge lands shall be accepted and no...

  6. 26 CFR 1.6654-5 - Payments of estimated tax.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Payments of estimated tax. 1.6654-5 Section 1.6654-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Additions to the Tax, Additional Amounts, and Assessable Penalties §...

  7. 26 CFR 1.6654-5 - Payments of estimated tax.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Payments of estimated tax. 1.6654-5 Section 1.6654-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Additions to the Tax, Additional Amounts, and Assessable Penalties §...

  8. 26 CFR 1.826-5 - Attribution of tax.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 8 2014-04-01 2014-04-01 false Attribution of tax. 1.826-5 Section 1.826-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Mutual Insurance Companies (other Than Life and Certain Marine...

  9. 26 CFR 1.165-5 - Worthless securities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Worthless securities. 1.165-5 Section 1.165-5... securities. (a) Definition of security. As used in section 165(g) and this section, the term “security” means.... (b) Ordinary loss. If any security which is not a capital asset becomes wholly worthless during...

  10. 43 CFR 3162.5-1 - Environmental obligations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Environmental obligations. 3162.5-1 Section 3162.5-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) ONSHORE OIL AND GAS OPERATIONS Requirements for Operating Rights Owners and...

  11. 43 CFR 3585.5-1 - Exploration license.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Exploration license. 3585.5-1 Section 3585.5-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS White...

  12. 43 CFR 3105.5-1 - Where filed.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Where filed. 3105.5-1 Section 3105.5-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL AND GAS LEASING Cooperative Conservation...

  13. 43 CFR 3105.5-1 - Where filed.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Where filed. 3105.5-1 Section 3105.5-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL AND GAS LEASING Cooperative Conservation...

  14. Photochemistry Of 2,5-Diacyl-1, 4-Dimethylbenzenes

    NASA Technical Reports Server (NTRS)

    Meador, Michael A.

    1989-01-01

    Experiments described in report revealed potentially useful aspects of photochemistry of 2,5-dibenzoyl-1, 4-dimethylbenzene (DBX) and 2,5-diacetyl-1, 4-dimethylbenzene (DAX). Behavior of these compounds reminiscent of orthoalkylphenyl ketones, studied from similar perspective for more than two decades.

  15. 43 CFR 3141.5-1 - Economic evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Economic evaluation. 3141.5-1 Section 3141... in Special Tar Sand Areas § 3141.5-1 Economic evaluation. Prior to any lease sale for a combined hydrocarbon lease, the authorized officer shall request an economic evaluation of the total...

  16. 43 CFR 3141.5-1 - Economic evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Economic evaluation. 3141.5-1 Section 3141... in Special Tar Sand Areas § 3141.5-1 Economic evaluation. Prior to any lease sale for a combined hydrocarbon lease, the authorized officer shall request an economic evaluation of the total...

  17. 26 CFR 1.165-5 - Worthless securities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Worthless securities. 1.165-5 Section 1.165-5... securities. (a) Definition of security. As used in section 165(g) and this section, the term “security” means.... (b) Ordinary loss. If any security which is not a capital asset becomes wholly worthless during...

  18. 26 CFR 1.1275-5 - Variable rate debt instruments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 11 2013-04-01 2013-04-01 false Variable rate debt instruments. 1.1275-5....1275-5 Variable rate debt instruments. (a) Applicability—(1) In general. This section provides rules for variable rate debt instruments. Except as provided in paragraph (a)(6) of this section, a...

  19. 26 CFR 1.1275-5 - Variable rate debt instruments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 11 2014-04-01 2014-04-01 false Variable rate debt instruments. 1.1275-5....1275-5 Variable rate debt instruments. (a) Applicability—(1) In general. This section provides rules for variable rate debt instruments. Except as provided in paragraph (a)(6) of this section, a...

  20. 26 CFR 1.1275-5 - Variable rate debt instruments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 11 2012-04-01 2012-04-01 false Variable rate debt instruments. 1.1275-5....1275-5 Variable rate debt instruments. (a) Applicability—(1) In general. This section provides rules for variable rate debt instruments. Except as provided in paragraph (a)(6) of this section, a...

  1. 26 CFR 1.1275-5 - Variable rate debt instruments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 11 2011-04-01 2011-04-01 false Variable rate debt instruments. 1.1275-5....1275-5 Variable rate debt instruments. (a) Applicability—(1) In general. This section provides rules for variable rate debt instruments. Except as provided in paragraph (a)(6) of this section, a...

  2. 26 CFR 1.165-5 - Worthless securities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Worthless securities. 1.165-5 Section 1.165-5... securities. (a) Definition of security. As used in section 165(g) and this section, the term “security” means.... (b) Ordinary loss. If any security which is not a capital asset becomes wholly worthless during...

  3. 26 CFR 1.165-5 - Worthless securities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Worthless securities. 1.165-5 Section 1.165-5... securities. (a) Definition of security. As used in section 165(g) and this section, the term “security” means.... (b) Ordinary loss. If any security which is not a capital asset becomes wholly worthless during...

  4. 26 CFR 1.66-5 - Effective date.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Effective date. 1.66-5 Section 1.66-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Definition of Gross Income, Adjusted Gross Income, and Taxable Income §...

  5. Domestic ducks and H5N1 influenza epidemic, Thailand.

    PubMed

    Songserm, Thaweesak; Jam-on, Rungroj; Sae-Heng, Numdee; Meemak, Noppadol; Hulse-Post, Diane J; Sturm-Ramirez, Katharine M; Webster, Robert G

    2006-04-01

    In addition to causing 12 human deaths and 17 cases of human infection, the 2004 outbreak of H5N1 influenza virus in Thailand resulted in the death or slaughter of 60 million domestic fowl and the disruption of poultry production and trade. After domestic ducks were recognized as silent carriers of H5N1 influenza virus, government teams went into every village to cull flocks in which virus was detected; these team efforts markedly reduced H5N1 infection. Here we examine the pathobiology and epidemiology of H5N1 influenza virus in the 4 systems of duck raising used in Thailand in 2004. No influenza viruses were detected in ducks raised in "closed" houses with high biosecurity. However, H5N1 influenza virus was prevalent among ducks raised in "open" houses, free-ranging (grazing) ducks, and backyard ducks.

  6. DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease.

    PubMed

    Suntharalingham, Jenifer P; Buonocore, Federica; Duncan, Andrew J; Achermann, John C

    2015-08-01

    DAX-1 (NR0B1) and SF-1 (NR5A1) are two nuclear receptor transcription factors that play a key role in human adrenal and reproductive development. Loss of DAX-1 function is classically associated with X-linked adrenal hypoplasia congenita. This condition typically affects boys and presents as primary adrenal insufficiency in early infancy or childhood, hypogonadotropic hypogonadism at puberty and impaired spermatogenesis. Late onset forms of this condition and variant phenotypes are increasingly recognized. In contrast, disruption of SF-1 only rarely causes adrenal insufficiency, usually in combination with testicular dysgenesis. Variants in SF-1/NR5A1 more commonly cause a spectrum of reproductive phenotypes ranging from 46,XY DSD (partial testicular dysgenesis or reduced androgen production) and hypospadias to male factor infertility or primary ovarian insufficiency. Making a specific diagnosis of DAX-1 or SF-1 associated conditions is important for long-term monitoring of endocrine and reproductive function, appropriate genetic counselling for family members, and for providing appropriate informed support for young people. PMID:26303087

  7. 26 CFR 1.6662-5 - Substantial and gross valuation misstatements under chapter 1.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... under chapter 1. 1.6662-5 Section 1.6662-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... Assessable Penalties § 1.6662-5 Substantial and gross valuation misstatements under chapter 1. (a) In general... imposed under chapter 1 of subtitle A of the Code that is required to be shown on a return is...

  8. 5 CFR Appendix A-1 to Subpart I... - Windchill Chart

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION (GENERAL) Pay for Duty Involving Physical Hardship or Hazard Pt. 550, Subpt. I, App. A-1 Appendix A-1 to Subpart I of Part 550—Windchill Chart EC01SE91.002 windchill chart in non-metric units... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Windchill Chart A Appendix A-1 to...

  9. 5 CFR 1.4 - Extent of the excepted service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Extent of the excepted service. 1.4 Section 1.4 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.4 Extent of the excepted service. (a) The excepted service shall include all...

  10. 26 CFR 1.801-5 - Total reserves.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TAXES Life Insurance Companies § 1.801-5 Total reserves. (a) Total reserves defined. For purposes of section 801(a) and § 1.801-3, the term “total reserves” is defined in section 801(c) as the sum of: (1) Life insurance reserves (as defined in section 801(b) and § 1.801-4), (2) Unearned premiums (as...

  11. 26 CFR 1.801-5 - Total reserves.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TAXES (CONTINUED) Life Insurance Companies § 1.801-5 Total reserves. (a) Total reserves defined. For purposes of section 801(a) and § 1.801-3, the term “total reserves” is defined in section 801(c) as the sum of: (1) Life insurance reserves (as defined in section 801(b) and § 1.801-4), (2) Unearned...

  12. 26 CFR 1.801-5 - Total reserves.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TAXES (CONTINUED) Life Insurance Companies § 1.801-5 Total reserves. (a) Total reserves defined. For purposes of section 801(a) and § 1.801-3, the term “total reserves” is defined in section 801(c) as the sum of: (1) Life insurance reserves (as defined in section 801(b) and § 1.801-4), (2) Unearned...

  13. 26 CFR 1.801-5 - Total reserves.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TAXES (CONTINUED) Life Insurance Companies § 1.801-5 Total reserves. (a) Total reserves defined. For purposes of section 801(a) and § 1.801-3, the term “total reserves” is defined in section 801(c) as the sum of: (1) Life insurance reserves (as defined in section 801(b) and § 1.801-4), (2) Unearned...

  14. Role of 5-hydroxytryptamine 1B (5-HT1B) receptors in the regulation of ethanol intake in rodents

    PubMed Central

    Sari, Youssef

    2012-01-01

    Evidence indicates that the serotonergic system is important in mediating dependence on and craving for alcohol. Among serotonin receptors, 5-hydroxytryptamine 1B (5-HT1B) receptors have been associated with drug abuse including alcohol. In this review, the neurocircuitry involving 5-HT1B receptors in central reward brain regions related to alcohol intake are discussed in detail. Emphasis has been placed on the pharmacological manipulations of 5-HT1B receptor-mediated alcohol intake. Furthermore, 5-HT1B auto- and hetero-receptors regulate alcohol intake through the regulatory mechanism involving release of 5-HT, gamma-aminobutyric acid (GABA), dopamine, and glutamate is evaluated. Thus, interactions between 5-HT1B receptors and these neurotransmitter systems are suggested to modulate alcohol-drinking behavior. This review on the role of 5-HT1B receptors in neurotransmitter release and consequent alcohol intake provides important information about the potential therapeutic role of 5-HT1B receptors for the treatment of alcohol dependence. PMID:23118018

  15. Hexahydro-1,3,5-trinitro-1,3,5-triazine mineralization by zerovalent iron and mixed anaerobic cultures.

    PubMed

    Oh, B T; Just, C L; Alvarez, P J

    2001-11-01

    Soil microcosms were used to evaluate the potential benefits of an integrated microbial-Fe0 system to treat groundwater contamination by RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine). Microcosms amended with both Fe0 filings and municipal anaerobic sludge mineralized RDX faster and to a greater extent than separate treatments, with up to 51% 14CO2 recovery after 77 d. The nitroso byproducts 1,3-dinitro-5-nitroso-1,3,5-triazacyclohexane (MNX), 1,3-dinitroso-5-nitro-1,3,5-triazacyclohexane (DNX), and 1,3,5-trinitroso-1,3,5-triazacyclohexane (TNX) were detected in all microcosms, although these compounds never accumulated above 5% of the added RDX on a molar basis. A soluble intermediate that was tentatively identified as methylenedinitramine [(O2NNH)2CH2] was relatively persistent, although it accumulated to a much lower extent in combined-treatment reactors than in sets with Fe0 or sludge alone. Some of the radiolabel was bound to soil and Fe0 and could not be extracted with CH3CN. This fraction, which was recovered by combustion with a biological oxidizer, was also found at lower concentrations in combined-treatment reactors. This work suggests that permeable reactive Fe0 barriers might be an effective approach to intercept and degrade RDX plumes and that treatment efficiency might be enhanced by biogeochemical interactions through bioaugmentation.

  16. D1/D5 dopamine receptors modulate spatial memory formation.

    PubMed

    da Silva, Weber C N; Köhler, Cristiano C; Radiske, Andressa; Cammarota, Martín

    2012-02-01

    We investigated the effect of the intra-CA1 administration of the D1/D5 receptor antagonist SCH23390 and the D1/D5 receptor agonist SKF38393 on spatial memory in the water maze. When given immediately, but not 3h after training, SCH23390 hindered long-term spatial memory formation without affecting non-spatial memory or the normal functionality of the hippocampus. On the contrary, post-training infusion of SKF38393 enhanced retention and facilitated the spontaneous recovery of the original spatial preference after reversal learning. Our findings demonstrate that hippocampal D1/D5 receptors play an essential role in spatial memory processing.

  17. Identification of ovine ruminal microbes capable of biotransforming hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Bioremediation is of great interest in the detoxification of soil contaminated with residues from explosives such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). Although there are numerous forms of in situ and ex situ bioremediation, ruminants would provide the option of an in situ bioreactor tha...

  18. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (Interagency Science Consultation Draft)

    EPA Science Inventory

    On March 10, 2016, the public comment draft Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine and the draft charge to external peer reviewers were released for public review and comment. The Toxicological Review and charge were reviewed internally by EPA and by othe...

  19. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (Public Comment Draft)

    EPA Science Inventory

    EPA is developing an Integrated Risk Information System (IRIS) assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and has released the draft assessment for public comment. When final, the assessment will appear on the IRIS database.

  20. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (External Review Draft)

    EPA Science Inventory

    The IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was released for external peer review in September 2016. The EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis suppor...

  1. On the origin of POU5F1

    PubMed Central

    2013-01-01

    Background Pluripotency is a fundamental property of early mammalian development but it is currently unclear to what extent its cellular mechanisms are conserved in vertebrates or metazoans. POU5F1 and POU2 are the two principle members constituting the class V POU domain family of transcription factors, thought to have a conserved role in the regulation of pluripotency in vertebrates as well as germ cell maintenance and neural patterning. They have undergone a complex pattern of evolution which is poorly understood and controversial. Results By analyzing the sequences of POU5F1, POU2 and their flanking genes, we provide strong indirect evidence that POU5F1 originated at least as early as a common ancestor of gnathostomes but became extinct in a common ancestor of teleost fishes, while both POU5F1 and POU2 survived in the sarcopterygian lineage leading to tetrapods. Less divergent forms of POU5F1 and POU2 appear to have persisted among cartilaginous fishes. Conclusions Our study resolves the controversial evolutionary relationship between teleost pou2 and tetrapod POU2 and POU5F1, and shows that class V POU transcription factors have existed at least since the common ancestor of gnathostome vertebrates. It provides a framework for elucidating the basis for the lineage-specific extinctions of POU2 and POU5F1. PMID:23659605

  2. D1/5 modulation of synaptic NMDA receptor currents

    PubMed Central

    Varela, Juan A.; Hirsch, Silke J.; Chapman, David; Leverich, Leah S.; Greene, Robert W.

    2009-01-01

    Converging evidence suggests that salience-associated modulation of behavior is mediated by the release of monoamines and that monoaminergic activation of D1/5 receptors is required for normal hippocampal-dependent learning and memory. However, it is not understood how D1/5 modulation of hippocampal circuits can affect salience-associated learning and memory. We have observed in CA1 pyramidal neurons that D1/5 receptor activation elicits a bi-directional long-term plasticity of NMDA receptor-mediated synaptic currents with the polarity of plasticity determined by NMDA receptor, NR2A/B subunit composition. This plasticity results in a decrease in the NR2A/NR2B ratio of subunit composition. Synaptic responses mediated by NMDA receptors that include NR2B subunits are potentiated by D1/5 receptor activation, while responses mediated by NMDA receptors that include NR2A subunits are depressed. Furthermore, these bidirectional, subunit-specific effects are mediated by distinctive intracellular signaling mechanisms. As there is a predominance of NMDA receptors composed of NR2A subunits observed in entorhinal-CA1 inputs and a predominance of NMDA receptors composed of NR2B subunits in CA3-CA1 synapses, potentiation of synaptic NMDA currents predominates in the proximal CA3-CA1 synapses, while depression of synaptic NMDA currents predominates in the distal entorhinal-CA1 synapses. Finally, all of these effects are reproduced by the release of endogenous monoamines through activation of D1/5 receptors. Thus, endogenous D1/5 activation can, 1) decrease the NR2A/B ratio of NMDAR subunit composition at glutamatergic synapses, a rejuvenation to a composition similar to developmentally immature synapses, and, 2) in CA1, bias NMDA receptor responsiveness towards the more highly processed tri-synaptic CA3-CA1 circuit and away from the direct entorhinal-CA1 input. PMID:19279248

  3. Morpheus 1.5A Lander Failure Investigation Results

    NASA Technical Reports Server (NTRS)

    Munday, Steve; Olansen, John

    2013-01-01

    On August 9th, 2012, the Morpheus 1.5 Vertical Testbed (VTB) crashed during Free Flight 2 (FF2) at KSC SLF, resulting in the loss of 1.5 VTB hardware. JSC/KSC Morpheus team immediately executed the pre-rehearsed Emergency Action Plan to protect personnel and property, so damage was limited to 1.5 VTB hardware. JSC/KSC Morpheus team secured data and mapped & recovered debris. Project had pre-declared loss of VTB to be a test failure, not a mishap.

  4. RELAP5 assessment: LOFT intermediate breaks L5-1 and L8-2. [PWR

    SciTech Connect

    Orman, J.L.; Kmetyk, L.N.

    1983-08-01

    The RELAP5 independent assessment project at Sandia National Laboratories is part of an overall effort funded by the NRC to determine the ability of various systems codes to predict the detailed thermal/hydraulic response of LWRs during accident and off-normal conditions. The RELAP5 code is being assessed at SNLA against test data from various integral and separate effects test facilities. As part of this assessment matrix, an intermediate break transient (L5-1) and a core uncovery transient (L8-2) performed at the LOFT facility have been analyzed. Transient calculations were done with both cycle 14 and cycle 18 of RELAP5/MOD1 and a comparison of the predictions was made. The results show that RELAP5/MOD1 did very well calculating the overall behavior for these intermediate break experiments, although there were a few quantitative disagreements.

  5. 26 CFR 1.48-5 - Electing small business corporations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Electing small business corporations. 1.48-5... business corporations. (a) In general. (1) In the case of an electing small business corporation (as... business corporation. The bases of all new section 38 properties which have a useful life falling within...

  6. 5 CFR 1.2 - Extent of the competitive service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Extent of the competitive service. 1.2 Section 1.2 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND... pursuant to statute or by the Office of Personnel Management (hereafter referred to in this subchapter...

  7. 5 CFR 7.1 - Discretion in filling vacancies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Discretion in filling vacancies. 7.1 Section 7.1 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES GENERAL PROVISIONS... Regulations. He shall exercise his discretion in all personnel actions solely on the basis of merit...

  8. 40 CFR 1.5 - Organization and general information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Organization and general information. 1... ORGANIZATION AND GENERAL INFORMATION Introduction § 1.5 Organization and general information. (a) The U.S. Environmental Protection Agency's basic organization consists of Headquarters and 10 Regional Offices....

  9. 40 CFR 1.5 - Organization and general information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Organization and general information. 1... ORGANIZATION AND GENERAL INFORMATION Introduction § 1.5 Organization and general information. (a) The U.S. Environmental Protection Agency's basic organization consists of Headquarters and 10 Regional Offices....

  10. Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences.

    PubMed

    Li, Qian; Holmes, Andrew; Ma, Li; Van de Kar, Louis D; Garcia, Francisca; Murphy, Dennis L

    2004-12-01

    Our previous studies found that serotonin transporter (SERT) knock-out mice showed increased sensitivity to minor stress and increased anxiety-like behavior but reduced locomotor activity. These mice also showed decreased density of 5-hydroxytryptamine (5-HT1A) receptors in the hypothalamus, amygdala, and dorsal raphe. To evaluate the contribution of hypothalamic 5-HT1A receptors to these phenotypes of SERT knock-out mice, two studies were conducted. Recombinant adenoviruses containing 5-HT1A sense and antisense sequences (Ad-1AP-sense and Ad-1AP-antisense) were used to manipulate 5-HT1A receptors in the hypothalamus. The expression of the 5-HT1A genes is controlled by the 5-HT1A promoter, so that they are only expressed in 5-HT1A receptor-containing cells. (1) Injection of Ad-1AP-sense into the hypothalamus of SERT knock-out mice restored 5-HT1A receptors in the medial hypothalamus; this effect was accompanied by elimination of the exaggerated adrenocorticotropin responses to a saline injection (minor stress) and reduced locomotor activity but not by a change in increased exploratory anxiety-like behavior. (2) To further confirm the observation in SERT-/- mice, Ad-1AP-antisense was injected into the hypothalamus of normal mice. The density and the function of 5-HT1A receptors in the medial hypothalamus were significantly reduced in Ad-1AP-antisense-treated mice. Compared with the control group (injected with Ad-track), Ad-1A-antisense-treated mice showed a significant reduction in locomotor activity, but again no changes in exploratory anxiety-like behaviors, tested by elevated plus-maze and open-field tests. Thus, the present results demonstrate that medial hypothalamic 5-HT1A receptors regulate stress responses and locomotor activity but may not regulate exploratory anxiety-like behaviors. PMID:15574737

  11. 5. ALABAMA, PICKENS CO., COCHRANE COLLAPSED RAILROAD BRIDGE 1.5 miles ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ALABAMA, PICKENS CO., COCHRANE COLLAPSED RAILROAD BRIDGE 1.5 miles N. from Cochrane on Ala. route 17. Copy of photo by Jack Donnell, Columbus, Ms., after bridge collapsed in 1973. Shows broken turn span and overturned center pier. Sarcone Photography, Columbus, Ms. Sep 1978. - Bridges of the Upper Tombigbee River Valley, Cochrane, Pickens County, AL

  12. 5. View of middle DR 2 antenna with DR 1 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. View of middle DR 2 antenna with DR 1 antenna in background. Photograph shows on left side at bottom foundation berm and along right side bottom stanchion concrete foundations at bottom structural steel assembly. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  13. A statistical phylogeography of influenza A H5N1

    PubMed Central

    Wallace, Robert G.; HoDac, HoangMinh; Lathrop, Richard H.; Fitch, Walter M.

    2007-01-01

    The geographic diffusion of highly pathogenic influenza A H5N1 has largely been traced from the perspective of the virus's victims. Birds of a variety of avian orders have been sampled across localities, and their infection has been identified by a general genetic test. Another approach tracks the migration from the perspective of the virus alone, by way of a phylogeography of H5N1 genetic sequences. Although several phylogenies in the literature have labeled H5N1 clades by geographic region, none has analytically inferred the history of the virus's migration. With a statistical phylogeography of 192 hemagglutinin and neuraminidase isolates, we show that the Chinese province of Guangdong is the source of multiple H5N1 strains spreading at both regional and international scales. In contrast, Indochina appears to be a regional sink, at the same time demonstrating bidirectional dispersal among localities within the region. An evolutionary trace of HA1 across the phylogeography suggests a mechanism by which H5N1 is able to infect repeated cycles of host species across localities, regardless of the host species first infected in each locale. The trace also hypothesizes amino acid replacements that preceded the first recorded outbreak of pathogenic H5N1 in Hong Kong, 1997. PMID:17360548

  14. Role of SKD1 Regulators LIP5 and IST1-LIKE1 in Endosomal Sorting and Plant Development1[OPEN

    PubMed Central

    Paez-Valencia, Julio; Miller, Nathan D.; Goodman, Kaija

    2016-01-01

    SKD1 is a core component of the mechanism that degrades plasma membrane proteins via the Endosomal Sorting Complex Required for Transport (ESCRT) pathway. Its ATPase activity and endosomal recruitment are regulated by the ESCRT components LIP5 and IST1. How LIP5 and IST1 affect ESCRT-mediated endosomal trafficking and development in plants is not known. Here we use Arabidopsis mutants to demonstrate that LIP5 controls the constitutive degradation of plasma membrane proteins and the formation of endosomal intraluminal vesicles. Although lip5 mutants were able to polarize the auxin efflux facilitators PIN2 and PIN3, both proteins were mis-sorted to the tonoplast in lip5 root cells. In addition, lip5 root cells over-accumulated PIN2 at the plasma membrane. Consistently with the trafficking defects of PIN proteins, the lip5 roots showed abnormal gravitropism with an enhanced response within the first 4 h after gravistimulation. LIP5 physically interacts with IST1-LIKE1 (ISTL1), a protein predicted to be the Arabidopsis homolog of yeast IST1. However, we found that Arabidopsis contains 12 genes coding for predicted IST1-domain containing proteins (ISTL1–12). Within the ISTL1–6 group, ISTL1 showed the strongest interaction with LIP5, SKD1, and the ESCRT-III-related proteins CHMP1A in yeast two hybrid assays. Through the analysis of single and double mutants, we found that the synthetic interaction of LIP5 with ISTL1, but not with ISTL2, 3, or 6, is essential for normal plant growth, repression of spontaneous cell death, and post-embryonic lethality. PMID:26983994

  15. 26 CFR 1.132-5 - Working condition fringes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... considered if the pattern of use of the employer-provided automobiles is designed to reduce Federal taxes...-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Excluded from Gross Income § 1.132-5...

  16. Vaccination of domestic ducks against H5N1 HPAI

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Domestic ducks play an important role in the epidemiology of H5N1 and H5N8 highly pathogenic avian influenza (HPAI) viruses, and therefore, successful control of HPAI in ducks is vital for the eradication of the disease in poultry. Vaccination can be used as a tool for supporting eradication by inc...

  17. Avian influenza vaccines against H5N1 'bird flu'.

    PubMed

    Li, Chengjun; Bu, Zhigao; Chen, Hualan

    2014-03-01

    H5N1 avian influenza viruses (AIVs) have spread widely to more than 60 countries spanning three continents. To control the disease, vaccination of poultry is implemented in many of the affected countries, especially in those where H5N1 viruses have become enzootic in poultry and wild birds. Recently, considerable progress has been made toward the development of novel avian influenza (AI) vaccines, especially recombinant virus vector vaccines and DNA vaccines. Here, we will discuss the recent advances in vaccine development and use against H5N1 AIV in poultry. Understanding the properties of the available, novel vaccines will allow for the establishment of rational vaccination protocols, which in turn will help the effective control and prevention of H5N1 AI.

  18. F5D-1 on ramp with flight technicians

    NASA Technical Reports Server (NTRS)

    1962-01-01

    The big block letters 'TEST' on the upper fuselage of this Douglas F5D-1 Skylancer (Bu. No. 139208/NASA tail number 212) denoted the craft as a test plane which was one of the fleet stabled at NASA Flight Research Center from 1961 to 1963 (redesignated the Dryden Flight Research Center in 1976). The calibration hangar, with the door partially open, is shown in the background while nearby the flight technicians are preparing the airplane for another research flight. In 1963 the F5D-1, NASA 212, was transferred to Ames Research Center, Mountain View, California, where it was flown on miscellaneous research projects including supersonic-transport landing studies. The F5D-1 was used to collect data on sink rates and approach characteristics. This particular F5D-1 was retired after several years, and in December 1975, it was loaned to Victor Valley College.

  19. 1. July 5, 1935 GENERAL VIEW OF BUILDING COMPLEX A ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. July 5, 1935 GENERAL VIEW OF BUILDING COMPLEX A portion of the Machinery Shed is visible left center between the Superintendent's Cottage and the General Utility Building - Tucson Plant Material Center, 3241 North Romero Road, Tucson, Pima County, AZ

  20. 43 CFR 3141.5-1 - Economic evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Leasing in Special Tar Sand Areas § 3141.5-1 Economic evaluation. Prior to any lease sale for a...

  1. 5. Abandoned mule trail tunnel. 1 mile from intersection with ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Abandoned mule trail tunnel. 1 mile from intersection with Newfound Gap Road looking SSE. - Great Smoky Mountains National Park Roads & Bridges, Clingmans Dome Road, Between Newfound Gap Road & Clingmans Dome, Gatlinburg, Sevier County, TN

  2. Hammerhead Crane (HH1) general view. Taken Jan 5, 1978. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Hammerhead Crane (HH-1) - general view. Taken Jan 5, 1978. Taken by Pearl Harbor photographer - U.S. Naval Base, Pearl Harbor, Exterior Cranes, Waterfront Crane Track System, Pearl City, Honolulu County, HI

  3. 1. Historic American Buildings Survey Lester Jones, Photographer July 5, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Lester Jones, Photographer July 5, 1940 VIEW FROM NORTHWEST - Colonel William Oliver Anderson House, Civil War Battle of Lexington State Park, Lexington, Lafayette County, MO

  4. 5. FEED BARN (STRUCTURE 1) SOUTHEAST END WITH WALL OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. FEED BARN (STRUCTURE 1) SOUTHEAST END WITH WALL OF MILKING BARN (STRUCTURE 2) IN FOREGROUND - Twin Oaks Dairy, Northwest of Metcalfe Road, off State Route 101 (Monterey Road), Coyote, Santa Clara County, CA

  5. Process to prepare 1,3-diamino-5-pentafluorosulfanylbenzene

    NASA Technical Reports Server (NTRS)

    St.clair, Terry L. (Inventor); St.clair, Anne K. (Inventor); Thrasher, Joseph S. (Inventor)

    1993-01-01

    A process was developed to prepare 1,3-diamino- 5-pentafluoro sulfanylbenzene. This process involved two steps: preparing the dinitro compound, 1,3-dinitro- 5-pentafluoro sulfanylbenzene, and reducing this compound to form the corresponding diamine. This diamine was reacted with various dianhydrides, diacidchlorides, and epoxy resins to form polyimides, polyamides, and cross linked epoxies. These polymers were used to prepare semi-permeable membranes, wire coatings, and films.

  6. Subtask 12C1: Determination of thermophysical properties of V-5Cr-5Ti

    SciTech Connect

    Porter, W.D.; Dinwiddie, R.B.; Simpson, W.A.; Grossbeck, M.L.

    1995-03-01

    Measurement of thermal expansion, thermal conductivity, specific heat, elastic constants to provide a single source of data on V-5Cr-5Ti to support design efforts on the V-Li blanket. The available tentative data on the physical properties required for thermal stress analyses are largely confined to pure vanadium. Using a V-5Cr-5Ti alloy, in a fully-annealed condition, a series of property measurements have been completed including linear thermal expansion, specific heat, thermal conductivity and the primary elastic constraints. These data have been submitted to the ITER Materials Property Data Handbook. 2 refs., 8 figs., 1 tab.

  7. 26 CFR 1.6662-5T - Substantial and gross valuation misstatements under chapter 1 (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Substantial and gross valuation misstatements under chapter 1 (temporary). 1.6662-5T Section 1.6662-5T Internal Revenue INTERNAL REVENUE SERVICE... Amounts, and Assessable Penalties § 1.6662-5T Substantial and gross valuation misstatements under...

  8. Plantaricin IIA-1A5 from Lactobacillus plantarum IIA-1A5 displays bactericidal activity against Staphylococcus aureus.

    PubMed

    Arief, I Isnafia; Budiman, C; Jenie, B Sri Laksmi; Andreas, E; Yuneni, A

    2015-01-01

    Plantaricin IIA-1A5 is a bacteriocin produced by Lactobacillus plantarum IIA-1A5 isolated from Indonesian beef. This research aimed to identify the genes involved in plantaricin IIA-1A5 production and examine its mode of action against Staphylococcus aureus. It has been reported that a bacteriocin structural gene, plnW, is present in genome of L. plantarum IIA-1A5. Here, we reported the presence of additional genes responsible for plantaricin precursor (plnA and plnEF) and a gene encoding the quorum sensor of histidine kinase (plnB). It indicates that genes involved in production of plantaricin IIA-1A5 are organized in at least two bacteriocin operons (plnABCD, plnEFI) and a structural plnW gene. Purified plantaricin IIA-1A5 yielded a single band in SDS-PAGE with apparent size of 6.4 kDa. Amino acid composition of purified plantaricin IIA-1A5 was mainly composed of cationic glutamic acid and cysteine that allowed the formation of disulphide bonds, suggesting plantaricin IIA-1A5 belongs to the pediocin-subclass of class II bacteriocins. Plantaricin IIA-1A5 displayed remarkable antibacterial activity against S. aureus, which was initiated by the adsorption of plantaricin IIA-1A5 onto the cell membrane of S. aureus. The adsorption is hypothesised to be facilitated by non-ionic interactions as it is reduced by the presence of organic solvents or detergents. This adsorption promoted leakage of cellular metabolites through the cell membrane of S. aureus, as indicated by the release of genetic and proteinaceous material of S. aureus observed at 260 and 280 nm, respectively. The leakage also promoted the release of divalent (Ca(2+), Mg(2+)) and monovalent (K(+)) cations. The release of these intracellular components might be due to pores formed in the cell membrane of S. aureus by plantaricin IIA-1A5 as shown by scanning electron microscopy. Altogether, the mode of action of plantaricin IIA-1A5 against S. aureus seems to be bactericidal as indicated by lysis of the cell

  9. Phylogeography of influenza A H5N1 clade 2.2.1.1 in Egypt

    PubMed Central

    2013-01-01

    Background Influenza A H5N1 has killed millions of birds and raises serious public health concern because of its potential to spread to humans and cause a global pandemic. While the early focus was in Asia, recent evidence suggests that Egypt is a new epicenter for the disease. This includes characterization of a variant clade 2.2.1.1, which has been found almost exclusively in Egypt. We analyzed 226 HA and 92 NA sequences with an emphasis on the H5N1 2.2.1.1 strains in Egypt using a Bayesian discrete phylogeography approach. This allowed modeling of virus dispersion between Egyptian governorates including the most likely origin. Results Phylogeography models of hemagglutinin (HA) and neuraminidase (NA) suggest Ash Sharqiyah as the origin of virus spread, however the support is weak based on Kullback–Leibler values of 0.09 for HA and 0.01 for NA. Association Index (AI) values and Parsimony Scores (PS) were significant (p-value < 0.05), indicating that dispersion of H5N1 in Egypt was geographically structured. In addition, the Ash Sharqiyah to Al Gharbiyah and Al Fayyum to Al Qalyubiyah routes had the strongest statistical support. Conclusion We found that the majority of routes with strong statistical support were in the heavily populated Delta region. In particular, the Al Qalyubiyah governorate appears to represent a popular location for virus transition as it represented a large portion of branches in both trees. However, there remains uncertainty about virus dispersion to and from this location and thus more research needs to be conducted in order to examine this. Phylogeography can highlight the drivers of H5N1 emergence and spread. This knowledge can be used to target public health efforts to reduce morbidity and mortality. For Egypt, future work should focus on using data about vaccination and live bird markets in phylogeography models to study their impact on H5N1 diffusion within the country. PMID:24325606

  10. 26 CFR 1.833-1 - Medical Loss Ratio under section 833(c)(5).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 8 2014-04-01 2014-04-01 false Medical Loss Ratio under section 833(c)(5). 1.833-1 Section 1.833-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Other Insurance Companies § 1.833-1 Medical Loss Ratio under section 833(c)(5). (a) In...

  11. Abiotic transformation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by green rusts.

    PubMed

    Larese-Casanova, Philip; Scherer, Michelle M

    2008-06-01

    The rate and extent of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) transformation was measured in the presence of carbonate and sulfate green rust suspended in solutions containing common groundwater anions. Formaldehyde (HCHO), nitrous oxide gas (N2O(g)), and ammonium (NH4+) were the major end products, accounting for about 70% of the carbon mass balance and about half of the nitrogen mass balance. Results from experiments with both 14C-RDX and LC-MS analysis indicate that the remaining carbon products are soluble and most likely small (< 50 Da). The transient appearance of 1,3-dinitro-5-nitroso-1,3,5-triazacyclohexane (MNX), 1,3-dinitroso-5-nitro-1,3,5-triazacyclohexane (DNX), and 1,3,5-trinitroso-1,3,5-triazacyclohexane (TNX) indicate that some nitro-group reduction occurred. The kinetics of RDX transformation was rapid with a half-life of less than an hour in a pH 7.0 KBr solution. Little difference in rates of RDX transformation or product distribution was observed between carbonate and sulfate green rust, and an apparent reaction order of 1.0 was measured with respect to Fe(II) in both green rusts. Phosphate anions completely inhibited RDX reduction, and carbonate and sulfate anions resulted in slower kinetics, and in some cases, an initial lag period, compared to bromide and chloride. Our results suggest that green rusts may contribute to abiotic natural attenuation of RDX in Fe-rich subsurface environments, but that it will be important to consider groundwater composition when assessing rates of attenuation.

  12. 26 CFR 1.611-5 - Depreciation of improvements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) INCOME TAXES (CONTINUED) Natural Resources § 1.611-5 Depreciation of improvements. (a) In general. Section 611 provides in the case of mines, oil and gas wells, other natural deposits, and timber that...). (b) Special rules for mines, oil and gas wells, other natural deposits and timber. (1) For...

  13. 43 CFR 8365.1-5 - Property and resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Property and resources. 8365.1-5 Section... Property and resources. (a) On all public lands, unless otherwise authorized, no person shall; (1..., cultural, archaeological or historic resource, natural object or area; (2) Willfully deface, remove...

  14. 43 CFR 8365.1-5 - Property and resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Property and resources. 8365.1-5 Section... Property and resources. (a) On all public lands, unless otherwise authorized, no person shall; (1..., cultural, archaeological or historic resource, natural object or area; (2) Willfully deface, remove...

  15. 43 CFR 8365.1-5 - Property and resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Property and resources. 8365.1-5 Section... Property and resources. (a) On all public lands, unless otherwise authorized, no person shall; (1..., cultural, archaeological or historic resource, natural object or area; (2) Willfully deface, remove...

  16. 46 CFR 160.049-5 - Inspections and tests. 1

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Specification for a Buoyant Cushion Plastic Foam § 160.049-5 Inspections and tests. 1 1 The manufacturer of a personal flotation device must meet 33 CFR 181.701 through 33 CFR 181.705 which require an instruction pamphlet for each device that is sold or offered for sale...

  17. 46 CFR 160.049-5 - Inspections and tests. 1

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Specification for a Buoyant Cushion Plastic Foam § 160.049-5 Inspections and tests. 1 1 The manufacturer of a personal flotation device must meet 33 CFR 181.701 through 33 CFR 181.705 which require an instruction pamphlet for each device that is sold or offered for sale...

  18. 46 CFR 160.049-5 - Inspections and tests. 1

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Specification for a Buoyant Cushion Plastic Foam § 160.049-5 Inspections and tests. 1 1 The manufacturer of a personal flotation device must meet 33 CFR 181.701 through 33 CFR 181.705 which require an instruction pamphlet for each device that is sold or offered for sale...

  19. 26 CFR 1.105-5 - Accident and health plans.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Accident and health plans. 1.105-5 Section 1.105... health plans. (a) In general. Sections 104(a)(3) and 105 (b), (c), and (d) exclude from gross income certain amounts received through accident or health insurance. Section 105(e) provides that for...

  20. 26 CFR 1.105-5 - Accident and health plans.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Accident and health plans. 1.105-5 Section 1.105... health plans. (a) In general. Sections 104(a)(3) and 105 (b), (c), and (d) exclude from gross income certain amounts received through accident or health insurance. Section 105(e) provides that for...

  1. 26 CFR 1.105-5 - Accident and health plans.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Accident and health plans. 1.105-5 Section 1.105... health plans. (a) In general. Sections 104(a)(3) and 105 (b), (c), and (d) exclude from gross income certain amounts received through accident or health insurance. Section 105(e) provides that for...

  2. 26 CFR 1.105-5 - Accident and health plans.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Accident and health plans. 1.105-5 Section 1.105... health plans. (a) In general. Sections 104(a)(3) and 105 (b), (c), and (d) exclude from gross income certain amounts received through accident or health insurance. Section 105(e) provides that for...

  3. 26 CFR 1.105-5 - Accident and health plans.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Accident and health plans. 1.105-5 Section 1.105... health plans. (a) In general. Sections 104(a)(3) and 105 (b), (c), and (d) exclude from gross income certain amounts received through accident or health insurance. Section 105(e) provides that for...

  4. 48 CFR 5.404-1 - Release procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PLANNING PUBLICIZING CONTRACT ACTIONS Release of Information 5.404-1 Release procedures. (a) Application. The agency head, or a designee, may release long-range acquisition estimates if the information will— (1) Assist industry in its planning and facilitate meeting the acquisition requirements; (2)...

  5. 43 CFR 8365.1-5 - Property and resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Property and resources. 8365.1-5 Section... Property and resources. (a) On all public lands, unless otherwise authorized, no person shall; (1..., cultural, archaeological or historic resource, natural object or area; (2) Willfully deface, remove...

  6. 26 CFR 1.150-5 - Filing notices and elections.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Filing notices and elections. 1.150-5 Section 1... notices and elections. (a) In general. Notices and elections under the following sections must be filed.... This section applies to notices and elections filed on or after January 19, 2001....

  7. 26 CFR 1.150-5 - Filing notices and elections.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Filing notices and elections. 1.150-5 Section 1... notices and elections. (a) In general. Notices and elections under the following sections must be filed.... This section applies to notices and elections filed on or after January 19, 2001....

  8. 26 CFR 1.150-5 - Filing notices and elections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Filing notices and elections. 1.150-5 Section 1... notices and elections. (a) In general. Notices and elections under the following sections must be filed.... This section applies to notices and elections filed on or after January 19, 2001....

  9. 26 CFR 1.1361-5 - Termination of QSub election.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 11 2011-04-01 2011-04-01 false Termination of QSub election. 1.1361-5 Section... Termination of QSub election. (a) In general—(1) Effective date. The termination of a QSub election is effective— (i) On the effective date contained in the revocation statement if a QSub election is...

  10. 26 CFR 1.1361-5 - Termination of QSub election.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 11 2013-04-01 2013-04-01 false Termination of QSub election. 1.1361-5 Section... Termination of QSub election. (a) In general—(1) Effective date. The termination of a QSub election is effective— (i) On the effective date contained in the revocation statement if a QSub election is...

  11. 26 CFR 1.1361-5 - Termination of QSub election.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 11 2012-04-01 2012-04-01 false Termination of QSub election. 1.1361-5 Section... Termination of QSub election. (a) In general—(1) Effective date. The termination of a QSub election is effective— (i) On the effective date contained in the revocation statement if a QSub election is...

  12. 26 CFR 1.150-5 - Filing notices and elections.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Filing notices and elections. 1.150-5 Section 1... notices and elections. (a) In general. Notices and elections under the following sections must be filed.... This section applies to notices and elections filed on or after January 19, 2001....

  13. 26 CFR 1.7872-5 - Exempted loans.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) INCOME TAXES (CONTINUED) General Actuarial Valuations § 1.7872-5 Exempted loans. (a) In general—(1) General rule. Except as provided in paragraph (a)(2) of this section, notwithstanding any other provision... loans. If a taxpayer structures a transaction to be a loan described in paragraph (b) of this...

  14. 26 CFR 1.7872-5 - Exempted loans.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) INCOME TAXES (CONTINUED) General Actuarial Valuations § 1.7872-5 Exempted loans. (a) In general—(1) General rule. Except as provided in paragraph (a)(2) of this section, notwithstanding any other provision... loans. If a taxpayer structures a transaction to be a loan described in paragraph (b) of this...

  15. 46 CFR 160.049-5 - Inspections and tests. 1

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Specification for a Buoyant Cushion Plastic Foam § 160.049-5 Inspections and tests. 1 1 The manufacturer of a personal flotation device must meet 33 CFR 181.701 through 33 CFR 181.705 which require an instruction pamphlet for each device that is sold or offered for sale...

  16. 46 CFR 160.049-5 - Inspections and tests. 1

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Specification for a Buoyant Cushion Plastic Foam § 160.049-5 Inspections and tests. 1 1 The manufacturer of a personal flotation device must meet 33 CFR 181.701 through 33 CFR 181.705 which require an instruction pamphlet for each device that is sold or offered for sale...

  17. 26 CFR 1.341-5 - Application of section.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Corporation at a gain of $12,000, which gain is attributable to the second building. (ii) X Corporation is a..., the gain of $12,000 to B is, accordingly, considered ordinary income. Example 3. The facts are the... § 1.341-2 and paragraph (a) of § 1.341-5. Example 4. (i) On January 2, 1948, C formed the...

  18. 5 CFR 4.1 - Prohibition against political activity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Prohibition against political activity. 4... PRACTICES (RULE IV) § 4.1 Prohibition against political activity. No person employed in the executive branch... occupying a position in the competitive service shall take any active part in political management or...

  19. 5 CFR 4.1 - Prohibition against political activity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Prohibition against political activity. 4... PRACTICES (RULE IV) § 4.1 Prohibition against political activity. No person employed in the executive branch... occupying a position in the competitive service shall take any active part in political management or...

  20. 5 CFR 4.1 - Prohibition against political activity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Prohibition against political activity. 4... PRACTICES (RULE IV) § 4.1 Prohibition against political activity. No person employed in the executive branch... occupying a position in the competitive service shall take any active part in political management or...

  1. 5 CFR 4.1 - Prohibition against political activity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Prohibition against political activity. 4... PRACTICES (RULE IV) § 4.1 Prohibition against political activity. No person employed in the executive branch... occupying a position in the competitive service shall take any active part in political management or...

  2. 5 CFR 4.1 - Prohibition against political activity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Prohibition against political activity. 4... PRACTICES (RULE IV) § 4.1 Prohibition against political activity. No person employed in the executive branch... occupying a position in the competitive service shall take any active part in political management or...

  3. 26 CFR 1.1275-5 - Variable rate debt instruments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Variable rate debt instruments. 1.1275-5 Section... Variable rate debt instruments. (a) Applicability—(1) In general. This section provides rules for variable rate debt instruments. Except as provided in paragraph (a)(6) of this section, a variable rate...

  4. 26 CFR 1.6654-5 - Payments of estimated tax.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Payments of estimated tax. 1.6654-5 Section 1... Payments of estimated tax. (a) In general. A payment of estimated tax by an individual shall be determined on Form 1040-ES. For the purpose of determining the estimated tax, the amount of gross income...

  5. Bis(1,1,1,5,5,5-hexafluoropentane-2,4-dionato)tetrakis(μ4-1,1,1,5,5,5-hexafluoropentane-2,2,4,4-tetraolato)copper(II)octatin(II): a prospective precursor for Cu-doped SnO2 films.

    PubMed

    Lieberman, Craig M; Filatov, Alexander S; Vreshch, Volodimir D; Dikarev, Evgeny V

    2013-12-15

    The crystal structure of a tin-rich heterometallic supramolecular product, [CuSn8(C5HF6O2)2(C5H2F6O4)4] or [Sn4(hfpt)2-Cu(hfac)2-Sn4(hfpt)2], (I), is reported (hfpt is the tetraanion of 1,1,1,5,5,5-hexafluoropentane-2,2,4,4-tetraol and hfac is the anion of 1,1,1,5,5,5-hexafluoropentane-2,4-dione). Reaction between tin(II) tetraolate, [Sn4(hfpt)2], and copper(II) β-diketonate, [Cu(hfac)2], was utilized for the preparation of (I). The asymmetric unit consists of the whole [Sn4(hfpt)2] unit and half of a [Cu(hfac)2] unit, with the Cu atom lying on an inversion center. Intermolecular Cu···O interactions from the axial positions of copper in [Cu(hfac)2] and O atoms of the hfpt ligand in [Sn4(hfpt)2] mediate the formation of a sandwich-type structure for (I). Additional intermolecular Sn···O interactions between neighbouring [Sn4(hfpt)2] units complete a two-dimensional network. PMID:24311485

  6. New ruthenium carboxylate complexes having a 1-5-. eta. sup 5 -cyclooctadienyl ligand

    SciTech Connect

    Osakada, Kohtaro; Grohmann, A.; Yamamoto, Akio )

    1990-07-01

    Reaction of 3-butenoic acid with Ru(cod)(cot) (cod) = 1-2-{eta}{sup 2}:5-6-{eta}{sup 2}-cyclooctadiene; cot = 1-6-{eta}{sup 6}-cyclooctatriene in the presence of PMe{sub 3} gives a new ruthenium(II) complex formulated as Ru(1-5-{eta}{sup 5}-C{sub 8}H{sub 11}){eta}{sup 1}(O),{eta}{sup 2}(C,C{prime}-OCOCH{sub 2}CH{double bond}CH{sub 2})(PMe{sub 3}) (1). X-ray crystallography revealed its structure as having a piano-stool coordination around the ruthenium center. Crystals of 1 are tetragonal, space group P4{sub 3}2{sub 1}2, with a = 12.559 (3) {angstrom}, c = 20.455 (4) {angstrom}, and Z = 8. {sup 1}H and {sup 13}C({sup 1}H) NMR spectra of 1 agree well for the structure with the allyl entity of the carboxylate {pi}-bonded through the C{double bond}C double bond to ruthenium.

  7. Fragrance material review on 1,3-benzodioxole-5-propanol, α-methyl-, 5-acetate.

    PubMed

    McGinty, D; Letizia, C S; Api, A M

    2012-09-01

    A toxicologic and dermatologic review of 1,3-benzodioxole-5-propanol, α-methyl-, 5-acetate when used as a fragrance ingredient is presented. 1,3-Benzodioxole-5-propanol, α-methyl-, 5-acetate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1,3-benzodioxole-5-propanol, α-methyl-, 5-acetate were evaluated, then summarized, and includes physical properties. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.

  8. N-Alkyl-, 1-C-Alkyl-, and 5-C-Alkyl-1,5-dideoxy-1,5-imino-(L)-ribitols as Galactosidase Inhibitors.

    PubMed

    Front, Sophie; Gallienne, Estelle; Charollais-Thoenig, Julie; Demotz, Stéphane; Martin, Olivier R

    2016-01-01

    A series of 1,5-dideoxy-1,5-imino-(l)-ribitol (DIR) derivatives carrying alkyl or functionalized alkyl groups were prepared and investigated as glycosidase inhibitors. These compounds were designed as simplified 4-epi-isofagomine (4-epi-IFG) mimics and were expected to behave as selective inhibitors of β-galactosidases. All compounds were indeed found to be highly selective for β-galactosidases versus α-glycosidases, as they generally did not inhibit coffee bean α-galactosidase or other α-glycosidases. Some compounds were also found to be inhibitors of almond β-glucosidase. The N-alkyl DIR derivatives were only modest inhibitors of bovine β-galactosidase, with IC50 values in the 30-700 μM range. Likewise, imino-L-ribitol substituted at the C1 position was found to be a weak inhibitor of this enzyme. In contrast, alkyl substitution at C5 resulted in enhanced β-galactosidase inhibitory activity by a factor of up to 1000, with at least six carbon atoms in the alkyl substituent. Remarkably, the 'pseudo-anomeric' configuration in this series does not appear to play a role. Human lysosomal β-galactosidase from leukocyte lysate was, however, poorly inhibited by all iminoribitol derivatives tested (IC50 values in the 100 μM range), while 4-epi-IFG was a good inhibitor of this enzyme. Two compounds were evaluated as pharmacological chaperones for a GM1-gangliosidosis cell line (R301Q mutation) and were found to enhance the mutant enzyme activity by factors up to 2.7-fold.

  9. Chemokine receptor 5 △32 allele in patients with severe pandemic (H1N1) 2009.

    PubMed

    Keynan, Yoav; Juno, Jennifer; Meyers, Adrienne; Ball, T Blake; Kumar, Anand; Rubinstein, Ethan; Fowke, Keith R

    2010-10-01

    Because chemokine receptor 5 (CCR5) may have a role in pulmonary immune response, we explored whether patients with severe pandemic (H1N1) 2009 were more likely to carry the CCR5Δ32 allele than were members of the general population. We found a large proportion of heterozygosity for the CCR5Δ32 allele among white patients with severe disease.

  10. Dissolution Properties of Dihydroxylammonium 5,5ʹ-Bistetrazole-1,1ʹ-diolate and Disodium 5,5ʹ-Bistetrazole-1,1ʹ-diolate in Water

    NASA Astrophysics Data System (ADS)

    Niu, Hu; Chen, Shusen; Jin, Shaohua; Shu, Qinghai; Li, Lijie; Shang, Fengqin

    2016-10-01

    The dissolution and thermochemical properties of dihydroxylammonium 5,5ʹ-bistetrazole-1,1ʹ-diolate (TKX-50) and its intermedium disodium 5,5ʹ-bistetrazole-1,1ʹ-diolate ([Na2(H2O)4]BTO) in water at 298.15 K were studied using a C-80 Calvet microcalorimeter. Empirical formulae for the calculation of the molar enthalpies of dissolution (ΔdissH), relative partial molar enthalpies (ΔdissHpartial), and relative apparent molar enthalpies (ΔdissHapparent) were deduced by the experimental results of the dissolution processes of TKX-50 and [Na2(H2O)4]BTO in water. Finally, the corresponding kinetic equations describing the dissolution processes were dα/dt = 10-2.95(1 - α)0.64 for the dissolution of TKX-50 in water and dα/dt = 10-2.76(1 - α)1.07 for the dissolution of [Na2(H2O)4]BTO in water.

  11. Fragrance material review on 3,5,5-trimethyl-1-hexanol.

    PubMed

    McGinty, D; Scognamiglio, J; Letizia, C S; Api, A M

    2010-07-01

    A toxicologic and dermatologic review of 3,5,5-trimethyl-1-hexanol when used as a fragrance ingredient is presented. 3,5,5-Trimethyl-1-hexanol is a member of the fragrance structural group branched chain saturated alcohols. The common characteristic structural elements of the alcohols with saturated branched chain are one hydroxyl group per molecule, and a C(4) to C(12) carbon chain with one or several methyl side chains. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. A safety assessment of the entire branched chain saturated alcohol group will be published simultaneously with this document; please refer to Belsito et al. (2010) for an overall assessment of the safe use of this material and all other branched chain saturated alcohols in fragrances.

  12. L5-S1 Laparoscopic Anterior Interbody Fusion

    PubMed Central

    Zeni, Tallal M.; Phillips, Frank M.; Mathur, Sameer; Zografakis, John G.; Moore, Ronald M.; Laguna, Luis E.

    2006-01-01

    Objective: We evaluated our experience with laparoscopic L5-S1 anterior lumbar interbody fusion (ALIF). Methods: This represents a retrospective analysis of consecutive patients who underwent L5-S1 laparoscopic ALIF between February 1998 and August 2003. Results: Twenty-eight patients underwent L5-S1 LAIF (15 males and 13 females). The mean age was 43 years (range, 26 to 67). Mean operative time was 225 minutes (range, 137 to 309 minutes). No conversions to an open procedure were necessary. Twenty-four (85.7%) patients underwent successful bilateral cage placement. Four patients (14.3%) in whom only a single cage could be placed underwent supplementary posterior pedicle screw placement. Mean length of stay (LOS) was 4.1 days (range, 2 to 15). Two patients underwent reoperation subacutely secondary to symptomatic lateral displacement of the cage. One patient developed radiculopathy 6 months postoperatively and required reoperation. One patient developed a small bowel obstruction secondary to adhesions to the cage requiring laparoscopic reoperation. Fusion was achieved in all patients. Visual analogue scale scores for back pain were significantly improved from 8.6±0.8 to 2.8±0.8 (P<0.0001) at 1 year. Conclusion: L5-S1 LAIF is feasible and safe with all the advantages of minimally invasive surgery. Fusion rates and pain improvement were comparable to those with an open repair. PMID:17575763

  13. Detection of 1,5-Anhydroglucitol by Electrochemical Impedance Spectroscopy

    PubMed Central

    Adamson, Teagan L.; Cook, Curtiss B.

    2014-01-01

    Multiple markers are used to assess glycemic control in patients with diabetes mellitus (DM). New technology that permits simultaneous detection of multiple biomarkers combined with those used at the point of care indicative of glycemic control, including glycemic variability determined from 1,5-anhydroglucitol measurement, could provide better management and further insight into the disease. This platform was based on previous research involving glucose detection and uses electrochemical impedance spectroscopy to detect a range of 1,5-anhydroglucitol concentrations at an optimal binding frequency. The enzyme pyranose oxidase was fixed to gold electrodes while a sine wave of sweeping frequencies was induced in purified solutions and in variable presence of whole blood. The optimal binding frequency for the detection of 1,5-anhydroglucitol was found to be 3.71 kHz. The impedance response compared to the concentration of target present was found to have a logarithmic slope of 7.04 with an R-squared value of 0.96. This response includes 2 experimental sets, a single test of a low concentration range and a high concentration range with 5 replicates. The relative standard deviation of the high range varied from 28% to 27% from lowest to highest concentrations. Best detection in complex solutions was found in lower blood concentrations of 0.5% and 1%, but maintained relatively high accuracy in concentrations 5% and 10%. The sensor platform was successfully evaluated at a high dynamic range of 1,5-AG in purified solutions. In the presence of whole blood, lowest percentages yielded the best results indicating that filtering interferents may be necessary in final device architecture. PMID:24876587

  14. The 1.5 MW wind turbine of tomorrow

    SciTech Connect

    De Wolff, T.J.; Sondergaard, H.

    1996-12-31

    The Danish company Nordtank is one of the pioneers within the wind turbine industry. Since 1981 Nordtank has installed worldwide more than 2300 wind turbine generators with a total name plate capacity that is exceeding 350 MW. This paper will describe two major wind turbine technology developments that Nordtank has accomplished during the last year: Site Optimization of Nordtank wind turbines: Nordtank has developed a flexible design concept for its WTGs in the 500/600 kW range, in order to offer the optimal WTG solution for any given site and wind regime. Nordtank`s 1.5 MW wind turbine: In September 1995, Nordtank was the first company to install a commercial 1.5 NM WTG. This paper will document the development process, the design as well as operations of the Nordtank 1.5 MW WTG.

  15. Spectral and correlated timing behaviour of GX 5-1

    NASA Astrophysics Data System (ADS)

    Kuulkers, E.; van der Klis, M.; Oosterbroek, T.; Asai, K.; Dotani, T.; van Paradijs, J.; Lewin, W. H. G.

    1994-09-01

    We have analyzed the X-ray spectral and fast timing behavior of the Z-source GX 5-1 using X-ray color-color diagrams (CDs), hardness-intensity diagrams (HIDs) and power spectra. We used all EXOSAT ME data on GX 5-1, a total of seven observations during 1983-1985. We detect, for the first time in GX 5-1, secular motion of the well-known 'Z' pattern through the CDs and HIDs. This behavior resembles Cyg X-2, but in GX 5-1 has a smaller amplitude. We find that the power spectra do not change when the 'Z' moves, and are only dependent on the position inside the 'Z'. We also report, for the first time in GX 5-1, indications of flaring-branch (FB) like behavior, both during one of our EXOSAT observations, and during observations done with Ginga. As the secular changes of the position of the 'Z' pattern in the CD and HID are relatively small we investigated in detail the systematic changes in the EXOSAT ME detectors using the only bright and steady X-ray 'standard star', the Crab Nebula. Finally, we determined an intrinsic CD of GX 5-1 (i.e. a soft photon flux-ratio versus hard photon flux-ratio diagram) in a model independent way, by applying a first order correction for the detector efficiency. It is shown, using data of the Crab Nebula, that this method works reasonably well for the determination of intrinsic colors.

  16. Spectral and correlated timing behaviour of GX 5-1

    NASA Technical Reports Server (NTRS)

    Kuulkers, E.; Van Der Klis, M.; Oosterbroek, T.; Asai, K.; Dotani, T.; Van Paradijs, J.; Lewin, W. H. G.

    1994-01-01

    We have analyzed the X-ray spectral and fast timing behavior of the Z-source GX 5-1 using X-ray color-color diagrams (CDs), hardness-intensity diagrams (HIDs) and power spectra. We used all EXOSAT ME data on GX 5-1, a total of seven observations during 1983-1985. We detect, for the first time in GX 5-1, secular motion of the well-known 'Z' pattern through the CDs and HIDs. This behavior resembles Cyg X-2, but in GX 5-1 has a smaller amplitude. We find that the power spectra do not change when the 'Z' moves, and are only dependent on the position inside the 'Z'. We also report, for the first time in GX 5-1, indications of flaring-branch (FB) like behavior, both during one of our EXOSAT observations, and during observations done with Ginga. As the secular changes of the position of the 'Z' pattern in the CD and HID are relatively small we investigated in detail the systematic changes in the EXOSAT ME detectors using the only bright and steady X-ray 'standard star', the Crab Nebula. Finally, we determined an intrinsic CD of GX 5-1 (i.e. a soft photon flux-ratio versus hard photon flux-ratio diagram) in a model independent way, by applying a first order correction for the detector efficiency. It is shown, using data of the Crab Nebula, that this method works reasonably well for the determination of intrinsic colors.

  17. 5β-Reduced steroids and human Δ(4)-3-ketosteroid 5β-reductase (AKR1D1).

    PubMed

    Chen, Mo; Penning, Trevor M

    2014-05-01

    5β-Reduced steroids are non-planar steroids that have a 90° bend in their structure to create an A/B cis-ring junction. This novel property is required for bile-acids to act as emulsifiers, but in addition 5β-reduced steroids have remarkable physiology and may act as potent tocolytic agents, endogenous cardiac glycosides, neurosteroids, and can act as ligands for orphan and membrane bound receptors. In humans there is only a single 5β-reductase gene AKR1D1, which encodes Δ(4)-3-ketosteroid-5β-reductase (AKR1D1). This enzyme is a member of the aldo-keto reductase superfamily, but possesses an altered catalytic tetrad, in which Glu120 replaces the conserved His residue. This predominant liver enzyme generates all 5β-dihydrosteroids in the C19-C27 steroid series. Mutations exist in the AKR1D1 gene, which result in loss of protein stability and are causative in bile-acid deficiency.

  18. Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity

    NASA Astrophysics Data System (ADS)

    Ratković, Zoran; Muškinja, Jovana; Burmudžija, Adrijana; Ranković, Branislav; Kosanić, Marijana; Bogdanović, Goran A.; Marković, Bojana Simović; Nikolić, Aleksandar; Arsenijević, Nebojša; Đorđevic, Snežana; Vukićević, Rastko D.

    2016-04-01

    A small series of 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles (aryl = 4-hydroxy-3-methoxyphenyl and 4-alkoxy-3-methoxyphenyl) was prepared, starting from 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one, dehydrozingerone, and its alkyl derivatives. Their in vitro cytotoxic activity against some cancer cell lines was tested, showing significant anticancer activity. All the new compounds were well characterized by IR, 1H, 13C NMR and ESI-MS spectroscopy and physical data, whereas structures of two of them were determined by single crystal X-ray analysis.

  19. C-Language Integrated Production System, Version 5.1

    NASA Technical Reports Server (NTRS)

    Riley, Gary; Donnell, Brian; Ly, Huyen-Anh VU; Culbert, Chris; Savely, Robert T.; Mccoy, Daniel J.; Giarratano, Joseph

    1992-01-01

    CLIPS 5.1 provides cohesive software tool for handling wide variety of knowledge with support for three different programming paradigms: rule-based, object-oriented, and procedural. Rule-based programming provides representation of knowledge by use of heuristics. Object-oriented programming enables modeling of complex systems as modular components. Procedural programming enables CLIPS to represent knowledge in ways similar to those allowed in such languages as C, Pascal, Ada, and LISP. Working with CLIPS 5.1, one can develop expert-system software by use of rule-based programming only, object-oriented programming only, procedural programming only, or combinations of the three.

  20. Synthesis and bioactivity of 5-(1-aryl-1H-tetrazol-5-ylsulfanylmethyl)-N-xylopyranosyl-1,3,4-oxa(thia)diazol-2-amines.

    PubMed

    He, Yao-Wu; Cao, Ling-Hua; Zhang, Jian-Bin; Wang, Duo-Zhi; Aisa, Haji Akber

    2011-04-01

    A series of new N'-[N-(2,3,4-tri-O-acetyl-β-d-xylopyranosyl)thiocarbamoyl]-2-[(1-aryl-1H-tetrazol-5-yl)sulfanyl]acetohydrazides 5a-5e were synthesized rapidly in high yields from 2-(1-aryl-1H-tetrazol-5-ylsulfanyl)acetohydrazides 3a-3e and 2,3,4-tri-O-acetyl-β-d-xylopyranosyl isothiocyanate 4, then 5a-5e were converted to a series of new 5-(1-aryl-1H-tetrazol-5-ylsulfanylmethyl)-N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-1,3,4-oxadiazole-2-amines 6a-6e and 5-(1-aryl-1H-tetrazol-5-ylsulfanylmethyl)-N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-1,3,4-thiadiazole-2-amines 7a-7e, respectively under mercuric acetate/alcohol system or acetic anhydride/phosphoric acid system, then deacetylated in the solution of CH(3)ONa/CH(3)OH. All of the novel compounds were characterized by IR, (1)H NMR, (13)C NMR, MS and elemental analysis. The structures of compounds 2e, 3e, 5a and 5c have been determined by X-ray diffraction analysis. Some of the synthesized compounds displayed PTP1B inhibition and microorganism inhibition. PMID:21353206

  1. Synthesis of the (5Z)-5-Pentacosenoic and 5-Pentacosynoic Acids as Novel HIV-1 Reverse Transcriptase Inhibitors

    PubMed Central

    Moreira, Lizabeth Giménez; Orellano, Elsie A.; Rosado, Karolyna; Guido, Rafael V. C.; Andricopulo, Adriano D.; Soto, Gabriela O.; Rodríguez, José W.; Sanabria-Ríos, David J.; Carballeira, Néstor M.

    2016-01-01

    The natural fatty acids (5Z)-5-pentacosenoic and (9Z)-9-pentacosenoic acids were synthesized for the first time in eight steps starting from either 4-bromo-1-butanol or 8-bromo-1-butanol and in 20-58% overall yields, while the novel fatty acids 5-pentacosynoic and 9-pentacosynoic acids were also synthesized in six steps and in 34-43% overall yields. The Δ5 acids displayed the best IC50’s (24-38 µM) against the HIV-1 reverse transcriptase (RT) enzyme, comparable to nervonic acid (IC50 = 12 µM). The Δ9 acids were not as effective towards HIV-RT with the (9Z)-9-pentacosenoic acid displaying an IC50 = 54 µM. Fatty acid chain length and position of the unsaturation was critical for the observed inhibition. Molecular modeling studies indicated the structural determinants underlying the biological activity of the most potent compounds. These results provide new insights into the structural requirements that must be present in fatty acids so as to enhance their inhibitory potential towards HIV-RT. PMID:26345647

  2. Stress-induced alterations in 5-HT1A receptor transcriptional modulators NUDR and Freud-1.

    PubMed

    Szewczyk, Bernadeta; Kotarska, Katarzyna; Daigle, Mireille; Misztak, Paulina; Sowa-Kucma, Magdalena; Rafalo, Anna; Curzytek, Katarzyna; Kubera, Marta; Basta-Kaim, Agnieszka; Nowak, Gabriel; Albert, Paul R

    2014-11-01

    The effect of stress on the mRNA and protein level of the 5-HT1A receptor and two of its key transcriptional modulators, NUDR and Freud-1, was examined in the prefrontal cortex (PFC) and hippocampus (Hp) using rodent models: olfactory bulbectomy (OB) and prenatal stress (PS) in male and female rats; chronic mild stress in male rats (CMS) and pregnancy stress. In PFC, CMS induced the most widespread changes, with significant reduction in both mRNA and protein levels of NUDR, 5-HT1A receptor and in Freud-1 mRNA; while in Hp 5-HT1A receptor and Freud-1 protein levels were also decreased. In male, but not female OB rats PFC Freud-1 and 5-HT1A receptor protein levels were reduced, while in Hp 5-HT1A receptor, Freud-1 and NUDR mRNA's but not protein were reduced. In PS rats PFC 5-HT1A receptor protein was reduced more in females than males; while in Hp Freud-1 protein was increased in females. In pregnancy stress, PFC NUDR, Freud-1 and 5-HT1A protein receptor levels were reduced, and in HP 5-HT1A receptor protein levels were also reduced; in HP only NUDR and Freud-1 mRNA levels were reduced. Overall, CMS and stress during pregnancy produced the most salient changes in 5-HT1A receptor and transcription factor expression, suggesting a primary role for altered transcription factor expression in chronic regulation of 5-HT1A receptor expression. By contrast, OB (in males) and PS (in females) produced gender-specific reductions in PFC 5-HT1A receptor protein levels, suggesting a role for post-transcriptional regulation. These and previous data suggest that chronic stress might be a key regulator of NUDR/Freud-1 gene expression.

  3. 5 CFR 1.1 - Positions and employees affected by the rules in this subchapter.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Positions and employees affected by the rules in this subchapter. 1.1 Section 1.1 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.1 Positions and employees affected by the rules...

  4. 5 CFR 1.1 - Positions and employees affected by the rules in this subchapter.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Positions and employees affected by the rules in this subchapter. 1.1 Section 1.1 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.1 Positions and employees affected by the rules...

  5. 5 CFR 1.1 - Positions and employees affected by the rules in this subchapter.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Positions and employees affected by the rules in this subchapter. 1.1 Section 1.1 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.1 Positions and employees affected by the rules...

  6. 5 CFR 1.1 - Positions and employees affected by the rules in this subchapter.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Positions and employees affected by the rules in this subchapter. 1.1 Section 1.1 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.1 Positions and employees affected by the rules...

  7. 5 CFR 1.1 - Positions and employees affected by the rules in this subchapter.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Positions and employees affected by the rules in this subchapter. 1.1 Section 1.1 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.1 Positions and employees affected by the rules...

  8. Treatment of Scabies: Comparison of Lindane 1% vs Permethrin 5.

    PubMed

    Rezaee, Elham; Goldust, Mohamad; Alipour, Houman

    2015-01-01

    Scabies, whose etiologic agent is Sarcoptes scabiei, is a neglected parasitic disease that is a major public health problem in many resourcepoor regions. Its current therapies include benzyl benzoate, lindane, permethrin, sulfur, crotamiton, monosulfiram, and oral ivermectin. The aim of this study was to compare the efficacy and safety of lindane 1% lotion vs permethrin 5% in the treatment of scabies. A total of 120 patients with scabies attending a dermatology outpatient department were included. Patients were randomly divided into two groups. Sixty patients and their family contacts received 5% permethrin cream and the other 60 received 1% lindane lotion. Treatment was evaluated at intervals of 2 and 4 weeks. Permethrin provided improvement in 48 patients (80%) after 2 weeks, whereas lindane was effective in only 28 patients (46.6%). Permethrin (5%) cream was found to be significantly more effective in the treatment of scabies compared with lindane in this study. Adverse effects were rare in both the permethrin and lindane groups.

  9. PIE on Safety-Tested AGR-1 Compact 5-1-1

    SciTech Connect

    Hunn, John D.; Morris, Robert Noel; Baldwin, Charles A.; Montgomery, Fred C.; Gerczak, Tyler J.

    2015-08-01

    Post-irradiation examination (PIE) is being performed in support of tristructural isotropic (TRISO) coated particle fuel development and qualification for High-Temperature Gas-cooled Reactors (HTGRs). AGR-1 was the first in a series of TRISO fuel irradiation experiments initiated in 2006 under the Advanced Gas Reactor (AGR) Fuel Development and Qualification Program; this work continues to be funded by the Department of Energy's Office of Nuclear Energy as part of the Advanced Reactor Technologies (ART) initiative. AGR-1 fuel compacts were fabricated at Oak Ridge National Laboratory (ORNL) in 2006 and irradiated for three years in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR) to demonstrate and evaluate fuel performance under HTGR irradiation conditions. PIE is being performed at INL and ORNL to study how the fuel behaved during irradiation, and to examine fuel performance during exposure to elevated temperatures at or above temperatures that could occur during a depressurized conduction cooldown event. This report summarizes safety testing of irradiated AGR-1 Compact 5-1-1 in the ORNL Core Conduction Cooldown Test Facility (CCCTF) and post-safety testing PIE.

  10. Irish Educational Studies, Vol. 5, Nos. 1 and 2, 1985.

    ERIC Educational Resources Information Center

    Coolahan, John, Ed.

    1986-01-01

    This issue of "Irish Educational Studies" focuses on curriculum and learning issues and includes: (1) "Aesthetic Perspectives in Curriculum Reform" (D. Murphy); (2) "Drama: Less Talk, More Action" (M. Drury); (3)" Out of Tune with Reality: Music and the School in Ireland" (M. O'Suilleabhain); (4) "Erotics, Not Hermeneutics" (T. Mullins); (5) "The…

  11. 43 CFR 3802.1-5 - Plan approval.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and Mining, Wilderness Review Program § 3802.1-5 Plan approval. (a) The authorized officer shall... the plan of operations to determine its acceptability. (b) The authorized officer shall review the... review of the plan of operations, the authorized officer shall give the operator written notice that:...

  12. 1. 8' x 10' enlargement from 4' x 5' negative ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. 8' x 10' enlargement from 4' x 5' negative Kevin Kriesel-Coons, Photographer, November 13, 1990 EXTERIOR OF HYDRO PLANT, SHOWING CURRENT STATE OF DISREPAIR. VIEW FROM WALKWAY OVER TAILRACE OF CROSSCUT CANAL TO THE LARGER, ORIGINAL CROSSCUT HYDRO PLANT. - Crosscut Steam Plant, Ancillary Hydro Unit, North side Salt River near Mill Avenue & Washington Street, Tempe, Maricopa County, AZ

  13. Screening for ASD with the Korean CBCL/1½-5

    ERIC Educational Resources Information Center

    Rescorla, Leslie; Kim, Young Ah; Oh, Kyung Ja

    2015-01-01

    To test the Child Behavior Checklist's (CBCL/1½-5) ability to screen for autism spectrum disorders (ASD), we studied Korean preschoolers: 46 with ASD, 111 with developmental delay (DD), 71 with other psychiatric disorders (OPD), and 228 non-referred (NR). The ASD group scored significantly higher than the other groups on the Withdrawn and…

  14. 26 CFR 1.46-5 - Qualified progress expenditures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Rules for Computing Credit for Investment in Certain Depreciable Property § 1.46-5 Qualified progress... in the case of self-constructed property) for construction of progress expenditure property. The taxpayer must reasonably estimate that the property will take at least 2 years to construct and that...

  15. 26 CFR 1.821-5 - Special transitional underwriting loss.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TAX (CONTINUED) INCOME TAXES Mutual Insurance Companies (other Than Life and Certain Marine Insurance Companies and Other Than Fire Or Flood Insurance Companies Which Operate on Basis of Perpetual Policies Or Premium Deposits) § 1.821-5 Special transitional underwriting loss. (a) In general. Section...

  16. 26 CFR 400.5-1 - Redemption by United States.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Redemption by United States. 400.5-1 Section... by United States. (a) Scope. The purpose of this section is to prescribe rules with respect to the provisions contained in section 7425(d), relating to redemption of real property by the United...

  17. 26 CFR 400.5-1 - Redemption by United States.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 18 2012-04-01 2012-04-01 false Redemption by United States. 400.5-1 Section... by United States. (a) Scope. The purpose of this section is to prescribe rules with respect to the provisions contained in section 7425(d), relating to redemption of real property by the United...

  18. 26 CFR 400.5-1 - Redemption by United States.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 18 2014-04-01 2014-04-01 false Redemption by United States. 400.5-1 Section... by United States. (a) Scope. The purpose of this section is to prescribe rules with respect to the provisions contained in section 7425(d), relating to redemption of real property by the United...

  19. 26 CFR 1.175-5 - Percentage limitation and carryover.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... upon which expenditures are made for soil or water conservation or for the prevention of erosion of...-5 Percentage limitation and carryover. (a) The limitation—(1) General rule. The amount of soil and... deduction for soil or water conservation expenditures has been taken into account in computing a...

  20. Saturn 1B and Saturn 5 computer programs, software

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Information on the progress and development of all Saturn 1B and Saturn 5 computer programs is presented. On-line, operating systems, test programs, and on-line display descriptions are given along with off-line programs. All programs are listed in tabular form.

  1. 5. TROJAN MILL, PRIMARY THICKENER No. 1 FROM WEST, c. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. TROJAN MILL, PRIMARY THICKENER No. 1 FROM WEST, c. 1914. TANK BARREL IS COMPLETE, BUT ADDITION ENCLOSURE NOT YET BEGUN. SAMPLING ADDITION SOUTH OF CRUSHED ORE BIN (CHANGE OF SIDING COLOR SHOWN AS COMPLETE. ROCK BIN VISIBLE ON FAR RIGHT. CREDIT WR. - Bald Mountain Gold Mill, Nevada Gulch at head of False Bottom Creek, Lead, Lawrence County, SD

  2. Science in Action Series: AGATE ( pt 1/5 )

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This show was made for the Office of Education at NASA Langley. The objective is to make math and science appealing to a middle school audience. This clip (pt 1/5 ) introduces the AGATE concept as a future alternative to cars.

  3. 26 CFR 1.815-5 - Other accounts defined.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Distributions to Shareholders § 1.815-5 Other accounts defined. The term other accounts, as..., 1958, paid-in surplus, capital, etc. To the extent that a distribution (or any portion thereof)...

  4. 43 CFR 3141.5-1 - Economic evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Leasing in Special Tar Sand Areas § 3141.5-1 Economic evaluation. Prior to any lease sale for a combined... resource on each proposed lease tract exclusive of coal, oil shale, or gilsonite....

  5. 26 CFR 400.5-1 - Redemption by United States.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Redemption by United States. 400.5-1 Section... by United States. (a) Scope. The purpose of this section is to prescribe rules with respect to the provisions contained in section 7425(d), relating to redemption of real property by the United...

  6. [Troubleshooting for Carestream GC1.5 Workstation].

    PubMed

    Yu, Liangning; Zhang, Junjie; Yang, Zhicheng

    2015-11-01

    This paper is maintenance of four kinds of failures of Carestream GC1.5 the workstation used several years to summarize, workstation software, change the host, burn, workstations transmission, and four kinds of failures of the specific case of itemized elimination steps are introduced.

  7. Purity Analysis Method of Dihydroxylammonium 5,5ʹ-Bistetrazole-1,1ʹ-diolate (TKX-50)

    NASA Astrophysics Data System (ADS)

    Xiong, Shu-Ling; Chen, Shu-Sen; Li, Li-Jie; Jin, Shao-Hua; Li, Jing-Lin

    2016-07-01

    A method for purity analysis of dihydroxylammonium 5,5ʹ-bistetrazole-1,1ʹ-diolate (TKX-50) using high-performance liquid chromatography (HPLC) was established by optimizing the chromatographic conditions: the detection wavelength was set at 200 nm, and the sample was separated by reverse-phase column (SinoChrom ODS-BP, 4.6 mm × 200 mm, 5 μm) using binary mobile phase acetonitrile and water (volume ratio of 50/50) with a flow rate of 1.0 mL/min at column temperature of 25°C. Normalization method, external standard method, and internal standard method were used to analyze the purity of TKX-50. The results indicate that the precision and accuracy of each method can satisfy the requirements of product analysis; however, the external standard method possesses higher accuracy and precision by comparison and is suggested to analyze the purity of TKX-50.

  8. Theoretical study on the HIV-1 integrase inhibitor 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2 H-tetrazol-5-yl)-propenone (5CITEP)

    NASA Astrophysics Data System (ADS)

    Nunthaboot, Nadtanet; Pianwanit, Somsak; Parasuk, Vudhichai; Kokpol, Sirirat; Wolschann, Peter

    2007-11-01

    1-(5-Chloroindol-3-yl)-3-hydroxy-3-(2 H-tetrazol-5-yl)-propenone (5CITEP) is an inhibitor of the HIV-1 integrase (IN). Theoretical studies were performed on the interaction of this inhibitor with surrounding amino acids. Density functional theory (DFT) calculations were conducted to identify the protonation state of HIV-1 integrase (IN), in particular, residues Lys156 and Lys159 and 5CITEP inhibitor. The results indicate that the both lysine residues are in protonated forms while 5CITEP is in de-protonated form. The binding energy of 5CITEP and its six surrounding amino acids, i.e., Thr66, Gln148, Glu152, Asn155, Lys156, and Lys159 is -41.33 kcal/mol. In addition, conformation analysis of 5CITEP was carried out to determine conformational minima of this compound. The calculations reveal that the lowest energy conformation of 5CITEP is close to that of X-ray conformation, as evidenced by energy difference of 1.5 kcal/mol only.

  9. Relating conformation to function in integrin α5β1.

    PubMed

    Su, Yang; Xia, Wei; Li, Jing; Walz, Thomas; Humphries, Martin J; Vestweber, Dietmar; Cabañas, Carlos; Lu, Chafen; Springer, Timothy A

    2016-07-01

    Whether β1 integrin ectodomains visit conformational states similarly to β2 and β3 integrins has not been characterized. Furthermore, despite a wealth of activating and inhibitory antibodies to β1 integrins, the conformational states that these antibodies stabilize, and the relation of these conformations to function, remain incompletely characterized. Using negative-stain electron microscopy, we show that the integrin α5β1 ectodomain adopts extended-closed and extended-open conformations as well as a bent conformation. Antibodies SNAKA51, 8E3, N29, and 9EG7 bind to different domains in the α5 or β1 legs, activate, and stabilize extended ectodomain conformations. Antibodies 12G10 and HUTS-4 bind to the β1 βI domain and hybrid domains, respectively, activate, and stabilize the open headpiece conformation. Antibody TS2/16 binds a similar epitope as 12G10, activates, and appears to stabilize an open βI domain conformation without requiring extension or hybrid domain swing-out. mAb13 and SG/19 bind to the βI domain and βI-hybrid domain interface, respectively, inhibit, and stabilize the closed conformation of the headpiece. The effects of the antibodies on cell adhesion to fibronectin substrates suggest that the extended-open conformation of α5β1 is adhesive and that the extended-closed and bent-closed conformations are nonadhesive. The functional effects and binding sites of antibodies and fibronectin were consistent with their ability in binding to α5β1 on cell surfaces to cross-enhance or inhibit one another by competitive or noncompetitive (allosteric) mechanisms.

  10. Semiconductor to metallic type transition in Ni1.5Fe1.5O4 ferrite

    NASA Astrophysics Data System (ADS)

    Aneeshkumar K., S.; Bhowmik, R. N.

    2016-05-01

    We have investigated electrical properties of Ni1.5Fe1.5O4 ferrite. The sample has been prepared by chemical coprecipitation route. The dc limit of conductivity has been derived from the fitting of ac conductivity data using Johnscher power law and Cole-Cole plot of impedance spectrum. The temperature dependence of dc conductivity data indicated a semiconductor to metallic type transition at 373K and metallic to semiconductor transition at 413K. Such electrical transition may be attributed to the effect of localization and de-localization of charge carriers in the hopping paths (Fe3+-O-Fe3+) and (Ni2+-O-Ni3+).

  11. Screening for ASD with the Korean CBCL/1½-5.

    PubMed

    Rescorla, Leslie; Kim, Young Ah; Oh, Kyung Ja

    2015-12-01

    To test the Child Behavior Checklist's (CBCL/1½-5) ability to screen for autism spectrum disorders (ASD), we studied Korean preschoolers: 46 with ASD, 111 with developmental delay (DD), 71 with other psychiatric disorders (OPD), and 228 non-referred (NR). The ASD group scored significantly higher than the other groups on the Withdrawn and DSM-Pervasive Developmental Problems (DSM-PDP) scales as well as attaining higher scores (p < .001) on seven items reflecting ASD. With a T ≥ 65 cutpoint on the DSM-PDP scale, sensitivity was 80 % for identifying ASD relative to the other three groups, but specificity varied across groups: NR = 87 %, OPD = 55 %, DD = 60 %, replicating in a non-Western sample results from previous studies. Results suggested that the CBCL/1½-5 performs best in Level 1 screening, namely differentiating children with ASD from children in the general population.

  12. Mineralogy and Thermal Properties of V-Type Asteroid 956 Elisa: Evidence for Diogenitic Material from the Spitzer IRS (5-35 Micrometers) Spectrum

    NASA Technical Reports Server (NTRS)

    Lim, Lucy F.; Emery, Joshua P.; Moskovitz, Nicholas A.

    2010-01-01

    We present the thermal infrared (5-35 micrometer) spectrum of 956 Elisa as measured by the Spitzer Infrared Spectrograph ("IRS"; Houck,1.R. et .11. [20041. Astrophys, 1. SuppL 154, 18-24) together with new ground-based lightcurve data and near-IR spectra. From the visible lightcurve photometry, we determine a rotation period of 16.494 +/- 0.001 h, identify the rotational phase of the Spitzer observations, and estimate the visible absolute magnitude (Hv) at that rotational phase to be 12.58 +/- 0.04. From radiometric analysis of the thermal flux spectrum, we find that at the time of observation 956 Elisa had a projected radius of 5.3 +/- 0.4 km with a visible albedo pv = 0.142+/- 0.022, significantly lower than that of the prototype V-type asteroid, 4 Vesta. (This corresponds to a radius of 5.2 +/- 0.4 km at lightcurve mean.) Analysis with the standard thermal model (STM) results in a sub-solar temperature of 292.3 +/- 2.8 K and beaming parameter eta = 1.16 +/- 0.05. Thermophysical modeling places a lower limit of 20 J m(exp -2)K(exp -1)s(exp -1/2) on the thermal inertia of the asteroid's surface layer (if the surface is very smooth) but more likely values fall between 30 and 150 J m(exp -2)K(exp -1)s(exp -1/2) depending on the sense of rotation. The emissivity spectrum, calculated by dividing the measured thermal flux spectrum by the modeled thermal continuum, exhibits mineralogically interpretable spectral features within the 9-12 micrometer reststrahlen band, the 15-16.5 micrometer Si-O-Si stretching region, and the 16-25 micrometer reststrahlen region that are consistent with pyroxene of diogenitic composition: extant diogenitic pyroxenes fall within the narrow compositional range W0(sub 2+/-1)En(sub 74+/-2)Fs(sub 24+/-1). Spectral deconvolution of the 9-12 micrometer reststrahlen features indicates that up to approximately 20% olivine may also be present, suggesting an olivine-diogenite-like mineralogy. The mid-IR spectrum is inconsistent with non

  13. H5N1 influenza viruses: facts, not fear.

    PubMed

    Palese, Peter; Wang, Taia T

    2012-02-14

    The ongoing controversy over publication of two studies involving the transmission in ferrets of H5N1 (H5) subtype influenza viruses and the recommendations of the National Science Advisory Board for Biosecurity to redact key details in the manuscripts call for an examination of relevant scientific facts. In addition, there are calls in the media to destroy the viruses, curtail future research in this area, and protect the public from such "frightening" research efforts. Fear needs to be put to rest with solid science and not speculation.

  14. Access 5 - Step 1: Human Systems Integration Program Plan (HSIPP)

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This report describes the Human System Interface (HSI) analysis, design and test activities that will be performed to support the development of requirements and design guidelines to facilitate the incorporation of High Altitude Long Endurance (HALE) Remotely Operated Aircraft (ROA) at or above FL400 in the National Airspace System (NAS). These activities are required to support the design and development of safe, effective and reliable ROA operator and ATC interfaces. This plan focuses on the activities to be completed for Step 1 of the ACCESS 5 program. Updates to this document will be made for each of the four ACCESS 5 program steps.

  15. Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison

    PubMed Central

    Loussouarn, Gildas; Sternberg, Damien; Nicole, Sophie; Marionneau, Céline; Le Bouffant, Francoise; Toumaniantz, Gilles; Barc, Julien; Malak, Olfat A.; Fressart, Véronique; Péréon, Yann; Baró, Isabelle; Charpentier, Flavien

    2016-01-01

    Mutations in Nav1.4 and Nav1.5 α-subunits have been associated with muscular and cardiac channelopathies, respectively. Despite intense research on the structure and function of these channels, a lot of information is still missing to delineate the various physiological and pathophysiological processes underlying their activity at the molecular level. Nav1.4 and Nav1.5 sequences are similar, suggesting structural and functional homologies between the two orthologous channels. This also suggests that any characteristics described for one channel subunit may shed light on the properties of the counterpart channel subunit. In this review article, after a brief clinical description of the muscular and cardiac channelopathies related to Nav1.4 and Nav1.5 mutations, respectively, we compare the knowledge accumulated in different aspects of the expression and function of Nav1.4 and Nav1.5 α-subunits: the regulation of the two encoding genes (SCN4A and SCN5A), the associated/regulatory proteins and at last, the functional effect of the same missense mutations detected in Nav1.4 and Nav1.5. First, it appears that more is known on Nav1.5 expression and accessory proteins. Because of the high homologies of Nav1.5 binding sites and equivalent Nav1.4 sites, Nav1.5-related results may guide future investigations on Nav1.4. Second, the analysis of the same missense mutations in Nav1.4 and Nav1.5 revealed intriguing similarities regarding their effects on membrane excitability and alteration in channel biophysics. We believe that such comparison may bring new cues to the physiopathology of cardiac and muscular diseases. PMID:26834636

  16. 1,5-Diarylbiguanides and their nickel(II) complexes.

    PubMed

    McMorran, David A; McAdam, C John; van der Salm, Holly; Gordon, Keith C

    2013-02-28

    1,5-Diarylbiguanides, where the aryl groups are phenyl (HL1), 3,5-dimethylphenyl (HL2), 3,5-dimethoxyphenyl (HL3), 4-t-butylphenyl (HL4) or 4-bromophenyl (HL5), have been prepared and characterised. HL3 and HL5 have been structurally characterised by X-ray crystallography, which shows them to adopt the expected tautomeric form for biguanides. They have extensive hydrogen-bonding interactions in the solid state, involving the biguanide NH groups supported by, in the case of HL3, the OCH3 aryl substituents or, in the case of HL5, Br···Br interactions. Reactions of HL1–HL4 with Ni(BF4)2 gives complexes of the type [Ni(HL)2](BF4)2, while reactions of HL1–HL4 with Ni(BF4)2 and triethylamine give neutral complexes of the type [Ni(L)2], where the biguanide ligand has been deprotonated at the N(ring) nitrogen. Both series of complexes were characterised in solution and the solid state. Cyclic voltammetry shows a largely irreversible Ni(II)/Ni(III) oxidation which becomes easier by ca. 70 mV upon ligand deprotonation, with more subtle variations resulting from the changes in aryl ring substituents. Infrared and 1H NMR spectroscopies both provide evidence for ligand deprotonation leading to the chelate ring becoming increasingly aromatised. X-ray crystallographic analyses of five of the complexes also show changes in bond lengths and angles within the chelate ring, consistent with increased electron delocalisation. A variety of hydrogen bonding motifs involving the complex ions, counterions and solvent molecules are found. The results of DFT calculations on both cationic and neutral complexes provide calculated structures consistent with the experimental ones and these, along with the results of vibrational spectroscopic studies, provide further evidence for increased aromatisation upon deprotonation. The potential for the complexes to act as tectons for the rational assembly of hydrogen bonded metallosupramolecules is discussed and the X-ray structure of such an

  17. Protective Efficacy of an H5N1 Inactivated Vaccine Against Challenge with Lethal H5N1, H5N2, H5N6, and H5N8 Influenza Viruses in Chickens.

    PubMed

    Zeng, Xianying; Chen, Pucheng; Liu, Liling; Deng, Guohua; Li, Yanbing; Shi, Jianzhong; Kong, Huihui; Feng, Huapeng; Bai, Jie; Li, Xin; Shi, Wenjun; Tian, Guobin; Chen, Hualan

    2016-05-01

    The Goose/Guangdong-lineage H5 viruses have evolved into diverse clades and subclades based on their hemagglutinin (HA) gene during their circulation in wild birds and poultry. Since late 2013, the clade 2.3.4.4 viruses have become widespread in poultry and wild bird populations around the world. Different subtypes of the clade 2.3.4.4 H5 viruses, including H5N1, H5N2, H5N6, and H5N8, have caused vast disease outbreaks in poultry in Asia, Europe, and North America. In this study, we developed a new H5N1 inactivated vaccine by using a seed virus (designated as Re-8) that contains the HA and NA genes from a clade 2.3.4.4 virus, A/chicken/Guizhou/4/13(H5N1) (CK/GZ/4/13), and its six internal genes from the high-growth A/Puerto Rico/8/1934 (H1N1) virus. We evaluated the protective efficacy of this vaccine in chickens challenged with one H5N1 clade 2.3.2.1b virus and six different subtypes of clade 2.3.4.4 viruses, including H5N1, H5N2, H5N6, and H5N8 strains. In the clade 2.3.2.1b virus DK/GX/S1017/13-challenged groups, half of the vaccinated chickens shed virus through the oropharynx and two birds (20%) died during the observation period. All of the control chickens shed viruses and died within 6 days of infection with challenge virus. All of the vaccinated chickens remained healthy following challenge with the six clade 2.3.4.4 viruses, and virus shedding was not detected from any of these birds; however, all of the control birds shed viruses and died within 4 days of challenge with the clade 2.3.4.4 viruses. Our results indicate that the Re-8 vaccine provides protection against different subtypes of clade 2.3.4.4 H5 viruses. PMID:27309064

  18. Kv1.5 Association Modifies Kv1.3 Traffic and Membrane Localization*S⃞

    PubMed Central

    Vicente, Rubén; Villalonga, Núria; Calvo, Maria; Escalada, Artur; Solsona, Carles; Soler, Concepció; Tamkun, Michael M.; Felipe, Antonio

    2008-01-01

    Kv1.3 activity is determined by raft association. In addition to Kv1.3, leukocytes also express Kv1.5, and both channels control physiological responses. Because the oligomeric composition may modify the channel targeting to the membrane, we investigated heterotetrameric Kv1.3/Kv1.5 channel traffic and targeting in HEK cells. Kv1.3 and Kv1.5 generate multiple heterotetramers with differential surface expression according to the subunit composition. FRET analysis and pharmacology confirm the presence of functional hybrid channels. Raft association was evaluated by cholesterol depletion, caveolae colocalization, and lateral diffusion at the cell surface. Immunoprecipitation showed that both Kv1.3 and heteromeric channels associate with caveolar raft domains. However, homomeric Kv1.3 channels showed higher association with caveolin traffic. Moreover, FRAP analysis revealed higher mobility for hybrid Kv1.3/Kv1.5 than Kv1.3 homotetramers, suggesting that heteromers target to distinct surface microdomains. Studies with lipopolysaccharide-activated macrophages further supported that different physiological mechanisms govern Kv1.3 and Kv1.5 targeting to rafts. Our results implicate the traffic and localization of Kv1.3/Kv1.5 heteromers in the complex regulation of immune system cells. PMID:18218624

  19. Platinum(II) 1,5-COD oxo complexes

    SciTech Connect

    Shan, H.; James, A.; Sharp, P.R.

    1998-11-02

    Three new types of platinum(II) oxo complexes--[(1,5-COD)Pt({mu}{sup 3}-O)(AuL)]{sub 2}(BF{sub 4}){sub 2} [1, L = PPh{sub 3}, PPh{sub 2}Et, PPh{sub 2}-i-Pr, P(o-tol){sub 3}, P(p-tol){sub 3}, P(p-MeOC{sub 6}H{sub 4}){sub 3}, P(p-CF{sub 3}C{sub 6}H{sub 4}){sub 3}], [(1,5-COD)Pt{l_brace}{mu}{sup 3}-O(AuL){sub 2}{r_brace}{sub 2}](BF{sub 4}){sub 2} (2), and [(1,5-COD){sub 4}Pt{sub 4}({mu}{sup 3}-O){sub 2}Cl{sub 2}]X{sub 2} (3, X = BF{sub 4}; 3a, X = CF{sub 3}SO{sub 3})--are obtained from oxo/chloro exchange reactions between (1,5-COD)PtCl{sub 2} and [(LAu){sub 3}({mu}{sup 3}-O)]BF{sub 4}. Crystals of 1 (L = PPh{sub 3}) from CDCl{sub 3} are triclinic. Crystals of 3a from CH{sub 2}Cl{sub 2}/toluene are trigonal. The structure of the cationic portion of 1 shows a planar (COD)-Pt({mu}-O){sub 2}Pt(COD) unit with slightly out-of-plane LAu{sup +} groups linearly coordinated to the oxo ligands. The structure of the cationic portion of 3a is similar and shows a slightly folded (COD)Pt({mu}-O){sub 2}Pt(COD) unit with out-of-plane [(COD)PtCl]{sup +} groups coordinated to the oxo ligands. Solutions of 3 in untreated CH{sub 2}Cl{sub 2} or CD{sub 2}Cl{sup 2} deposit crystals of [(1,5-COD){sub 4}Pt{sub 4}({mu}{sup 3}-O){sub 2}({mu}{sup 2}-OH)](BF{sub 4}){sub 3} (4) which are monoclinic. The core structure of the cationic portion of 4 shows a tetranuclear platinum cation in which the metal atoms occupy the corners of a distorted tetrahedron and two {mu}{sup 3}-oxo ligands and one {mu}{sup 2}-hydroxo ligand bridge the four platinum atoms. Reaction of 1 (L = PPh{sub 3}) with PPh{sub 3} gives OPPh{sub 3} and [(Ph{sub 3}P){sub 3}PtAuPPh{sub 3}]BF{sub 4} (5) which is also obtained from (Ph{sub 3}P){sub 4}Pt and Ph{sub 3}-PAuBF{sub 4}. Crystals of 5 from THF are monoclinic. The structure of 5 consists of an L{sub 3}Pt-AuL cation where the Au atom is linear 2-coordinate and the Pt atom is distorted square-planar 4-coordinate.

  20. 5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis.

    PubMed Central

    Sharp, T.; Bramwell, S. R.; Grahame-Smith, D. G.

    1989-01-01

    1. An intracerebral perfusion method, brain microdialysis, was used to assess changes of 5-hydroxytryptamine (5-HT) release in the ventral hippocampus of the chloral hydrate-anaesthetized rat in response to systemic administration of a variety of 5-HT1 receptor agonists. 2. A stable output of reliably detectable endogenous 5-HT was measured in dialysates collected from ventral hippocampus with the 5-HT reuptake inhibitor, citalopram, present in the perfusion medium. 3. Under these conditions the putative 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) caused a dose-dependent (5-250 micrograms kg-1, s.c.) reduction of 5-HT in hippocampal dialysates. 4. Similarly, the putative 5-HT1A agonists gepirone (5 mg kg-1, s.c.), ipsapirone (5 mg kg-1, s.c.) and buspirone (5 mg kg-1, s.c.) markedly reduced levels of 5-HT in hippocampal perfusates whereas their common metabolite 1-(2-pyrimidinyl) piperazine (5 mg kg-1, s.c.), which does not bind to central 5-HT1A recognition sites, had no effect. 5. 5-Methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU 24969), a drug with reported high affinity for brain 5-HT1B binding sites, also produced a dose-dependent (0.25-5 mg kg-1, s.c.) decrease of hippocampal 5-HT output. 6. These data are direct biochemical evidence that systemically administered putative 5-HT1A and 5-HT1B agonists markedly inhibit 5-HT release in rat ventral hippocampus in vivo. PMID:2466516