Science.gov

Sample records for 5 6 7

  1. 6 CFR 5.7 - Classified information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... classified under Executive Order 12958 (3 CFR, 1996 Comp., p. 333) or any other executive order, the... 6 Domestic Security 1 2010-01-01 2010-01-01 false Classified information. 5.7 Section 5.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY DISCLOSURE OF RECORDS AND...

  2. Synthesis of Natural Homoisoflavonoids Having Either 5,7-Dihydroxy-6-methoxy or 7-Hydroxy-5,6-dimethoxy Groups.

    PubMed

    Lee, Hyungjun; Yuan, Yue; Rhee, Inmoo; Corson, Timothy W; Seo, Seung-Yong

    2016-08-13

    Naturally occurring homoisoflavonoids containing either 5,7-dihydroxy-6-methoxy or 7-hydroxy-5,6-dimethoxy groups such as the antiangiogenic homoisoflavanone, cremastranone, were synthesized via three or four linear steps from the known 4-chromenone. This facile synthesis includes chemoselective 1,4-reduction of 4-chromenone and selective deprotection of 3-benzylidene-4-chromanone a containing C7-benzyloxy group.

  3. 7 CFR 1774.5-1774.6 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true 1774.5-1774.6 Section 1774.5-1774.6 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) SPECIAL EVALUATION ASSISTANCE FOR RURAL COMMUNITIES AND HOUSEHOLDS PROGRAM (SEARCH)...

  4. 7 CFR 1774.5-1774.6 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false 1774.5-1774.6 Section 1774.5-1774.6 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) SPECIAL EVALUATION ASSISTANCE FOR RURAL COMMUNITIES AND HOUSEHOLDS PROGRAM (SEARCH)...

  5. Fragrance material review on (3aalpha,4alpha,6alpha,7alpha,7aalpha)-3a,4,5,6,7,7a-hexahydro-3-methyl-5-methylene-4,7-methano-1H-inden-6-yl acetate.

    PubMed

    Bhatia, S P; Jones, L; Letizia, C S; Api, A M

    2008-12-01

    A toxicologic and dermatologic review of (3aalpha,4alpha,6alpha,7alpha,7aalpha)-3a,4,5,6,7,7a-hexahydro-3-methyl-5-methylene-4,7-methano-1H-inden-6-yl acetate when used as a fragrance ingredient is presented.

  6. Identification of 5,6,7,8-tetrahydropterin and 5,6,7,8-tetrahydrobiopterin in Drosophila melanogaster.

    PubMed

    Guillamón, J J; Ferré, J

    1988-04-15

    Using reversed-phase high-performance liquid chromatography with electrochemical detection we have demonstrated the occurrence of 5,6,7,8-tetrahydropterin and 5,6,7,8-tetrahydrobiopterin in Drosophila melanogaster. The former is the first time that has been detected in vivo. The identification has been based on the retention times, hydrodinamic voltagrams and the differential concentration in three strains of Drosophila melanogaster. Compared to the wild type, the Punch2 mutant has diminished levels of both pteridines, whereas Henna-recessive3 lacks completely tetrahydropterin and has increased levels of tetrahydrobiopterin, as expected according to their biochemical lesions.

  7. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  8. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  9. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  10. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  11. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  12. Trisodium citrate, Na3(C6H5O7)

    PubMed Central

    Rammohan, Alagappa; Kaduk, James A.

    2016-01-01

    The crystal structure of anhydrous tris­odium citrate, Na3(C6H5O7), has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional theory (DFT). There are two independent five-coordinate Na+ and one six-coordinate Na+ cations in the asymmetric unit. The [NaO5] and [NaO6] polyhedra share edges and corners to form a three-dimensional framework. There are channels parallel to the a and b axes in which the remainder of the citrate anions reside. The only hydrogen bonds are an intra­molecular one between the hy­droxy group and one of the terminal carboxyl­ate O atoms and an intermolecular one between a methylene group and the hydroxyl O atom. PMID:27308044

  13. Rare-earth plasma extreme ultraviolet sources at 6.5-6.7 nm

    SciTech Connect

    Otsuka, Takamitsu; Higashiguchi, Takeshi; Yugami, Noboru; Yatagai, Toyohiko; Kilbane, Deirdre; White, John; Dunne, Padraig; O'Sullivan, Gerry; Jiang, Weihua; Endo, Akira

    2010-09-13

    We have demonstrated a laser-produced plasma extreme ultraviolet source operating in the 6.5-6.7 nm region based on rare-earth targets of Gd and Tb coupled with a Mo/B{sub 4}C multilayer mirror. Multiply charged ions produce strong resonance emission lines, which combine to yield an intense unresolved transition array. The spectra of these resonant lines around 6.7 nm (in-band: 6.7 nm {+-}1%) suggest that the in-band emission increases with increased plasma volume by suppressing the plasma hydrodynamic expansion loss at an electron temperature of about 50 eV, resulting in maximized emission.

  14. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  15. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  16. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  17. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  18. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  19. Direct Access to 6/5/7/5- and 6/7/5/5-Fused Tetracyclic Triterpenoids via Divergent Transannular Aldol Reaction of Lanosterol-Derived Diketone

    PubMed Central

    Ignatenko, Vasily A.; Han, Yong

    2013-01-01

    In an effort to access biologically relevant chemical space, a complex natural product-derived non-symmetrical diketone was prepared as a substrate for divergent transannular aldol reactions. The use of common aldol conditions resulted in predominant syn-addition via pathway a, while the use of alumina provided access to the anti-adduct. Screening of a range of Lewis acids of varying strength unexpectedly resulted in the formation of aldol products with 6/7/5/5-fused molecular skeleton via pathway b. PMID:24161022

  20. AN ATLAS OF z = 5.7 AND z = 6.5 Ly{alpha} EMITTERS ,

    SciTech Connect

    Hu, E. M.; Cowie, L. L.; Barger, A. J.; Capak, P.; Kakazu, Y.; Trouille, L. E-mail: cowie@ifa.hawaii.ed E-mail: trouille@astro.wisc.ed E-mail: kakazu@astro.caltech.ed

    2010-12-10

    We present an atlas of 88 z {approx} 5.7 and 30 z {approx} 6.5 Ly{alpha} emitters obtained from a wide-field narrowband survey. We combined deep narrowband imaging in 120 A bandpass filters centered at 8150 A and 9140 A with deep BVRIz broadband imaging to select high-redshift galaxy candidates over an area of 4180 arcmin{sup 2}. The goal was to obtain a uniform selection of comparable depth over the seven targeted fields in the two filters. For the GOODS-North region of the Hubble Deep Field-North field, we also selected candidates using a 120 A filter centered at 9210 A. We made spectroscopic observations with Keck DEIMOS of nearly all the candidates to obtain the final sample of Ly{alpha} emitters. At the 3.3 A resolution of the DEIMOS observations the asymmetric profile for Ly{alpha} emission can be clearly seen in the spectra of nearly all the galaxies. We show that the spectral profiles are surprisingly similar for many of the galaxies and that the composite spectral profiles are nearly identical at z = 5.7 and z = 6.5. We analyze the distributions of line widths and Ly{alpha} equivalent widths and find that the lines are marginally narrower at the higher redshift, with median values of 0.77 A at z = 6.5 and 0.92 A at z = 5.7. The line widths have a dependence on the Ly{alpha} luminosity of the form {approx}L {sup 0.3}{sub {alpha}}. We compare the surface densities and the luminosity functions at the two redshifts and find that there is a multiplicative factor of two decrease in the number density of bright Ly{alpha} emitters from z = 5.7 to z = 6.5, while the characteristic luminosity is unchanged.

  1. 7 CFR 5.6 - Revision of the parity price of a commodity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Revision of the parity price of a commodity. 5.6 Section 5.6 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.6 Revision of the parity price of a commodity. (a) Initiation of hearings. The “modernized” parity...

  2. 7 CFR 5.6 - Revision of the parity price of a commodity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Revision of the parity price of a commodity. 5.6 Section 5.6 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.6 Revision of the parity price of a commodity. (a) Initiation of hearings. The “modernized” parity...

  3. 7 CFR 5.6 - Revision of the parity price of a commodity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Revision of the parity price of a commodity. 5.6 Section 5.6 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.6 Revision of the parity price of a commodity. (a) Initiation of hearings. The “modernized” parity...

  4. 7 CFR 5.6 - Revision of the parity price of a commodity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Revision of the parity price of a commodity. 5.6 Section 5.6 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.6 Revision of the parity price of a commodity. (a) Initiation of hearings. The “modernized” parity...

  5. 7 CFR 5.6 - Revision of the parity price of a commodity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Revision of the parity price of a commodity. 5.6 Section 5.6 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.6 Revision of the parity price of a commodity. (a) Initiation of hearings. The “modernized” parity...

  6. 8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition of classification. As a condition of classification and...

  7. 8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition of classification. As a condition of classification and...

  8. 8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition of classification. As a condition of classification and...

  9. Synthesis and biological activity of substituted-4,5,6,7-tetrahydrothieno pyridines: a review.

    PubMed

    Sangshetti, Jaiprakash N; Zambare, Abhay S; Khan, Firoz A Kalam; Gonjari, Indrajeet; Zaheer, Zahid

    2014-01-01

    4,5,6,7-Tetrahydrothieno pyridine is an important class of heterocyclic nucleus. Various 4,5,6,7-tetrahydrothieno pyridine derivatives have been synthesized and evaluated for various biological activities in different models with desired findings. Some analogs have shown potent biological activities and may be considered as lead molecule for the development of future drugs. Number of drug molecules are available in the market and many molecules are in clinical development containing 4,5,6,7-tetrahydrothieno pyridine nucleus as an important core. This review is an attempt to organize the chemical and biological aspects of 4,5,6,7-tetrahydrothieno pyridine analogs reported in last 20 year to till date. Review mainly focuses on the important role of the core in synthesis of drug or drug intermediates giving emphasis on synthetic schemes and biological activities of the different 4,5,6,7-tetrahydrothieno pyridine analogs. PMID:25373848

  10. 5. CONTEXTUAL VIEW WEST OF (LEFT TO RIGHT) FEATURES 7,6,2,8, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. CONTEXTUAL VIEW WEST OF (LEFT TO RIGHT) FEATURES 7,6,2,8, AND 1 WITHIN MILL COMPLEX. - Juniata Mill Complex, 22.5 miles Southwest of Hawthorne, between Aurora Crater & Aurora Peak, Hawthorne, Mineral County, NV

  11. Assessment of RELAP5/MOD3 Version 7 based on the BETHSY Test 6. 2 TC

    SciTech Connect

    Choi, C.J. ); Roth, P.A.; Schultz, R.R. )

    1992-01-01

    This document provides a discussion of the BETHSY test 6.2 TC which was conducted to investigate thermal hydraulic phenomena during a 5% cold leg SBLOCA and to provide high quality data for advanced thermal-hydraulic code assessment. BETHSY test 6.2 TC was analyzed using RELAP5/MOD3 version 7o.

  12. 8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition... section 101(a)(15)(S) of the Act, nonimmigrants in S classification must have executed Form I-854, Part...

  13. 8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition... section 101(a)(15)(S) of the Act, nonimmigrants in S classification must have executed Form I-854, Part...

  14. 8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition... section 101(a)(15)(S) of the Act, nonimmigrants in S classification must have executed Form I-854, Part...

  15. Synthesis and reactivity of N-heterocycle-B(C6F5)3 complexes. 4. Competition between pyridine- and pyrrole-type substrates toward B(C6F5)3: structure and dynamics of 7-B(C6F5)3-7-azaindole and [7-Azaindolium]+[HOB(C6F5)3]-.

    PubMed

    Focante, Francesca; Camurati, Isabella; Resconi, Luigi; Guidotti, Simona; Beringhelli, Tiziana; D'Alfonso, Giuseppe; Donghi, Daniela; Maggioni, Daniela; Mercandelli, Pierluigi; Sironi, Angelo

    2006-02-20

    Reaction between 7-azaindole and B(C6F5)3 quantitatively yields 7-(C6F5)3B-7-azaindole (4), in which B(C6F5)3 coordinates to the pyridine nitrogen of 7-azaindole, leaving the pyrrole ring unreacted even in the presence of a second equivalent of B(C6F5)3. Reaction of 7-azaindole with H2O-B(C6F5)3 initially produces [7-azaindolium]+[HOB(C6F5)3]- (5) which slowly converts to 4 releasing a H2O molecule. Pyridine removes the borane from the known complexes (C6F5)3B-pyrrole (1) and (C6F5)3B-indole (2), with formation of free pyrrole or indole, giving the more stable adduct (C6F5)3B-pyridine (3). The competition between pyridine and 7-azaindole for the coordination with B(C6F5)3 again yields 3. The molecular structures of compounds 4 and 5 have been determined both in the solid state and in solution and compared to the structures of other (C6F5)3B-N-heterocycle complexes. Two dynamic processes have been found in compound 4. Their activation parameters (DeltaH = 66 (3) kJ/mol, DeltaS = -18 (10) J/mol K and DeltaH = 76 (5) kJ/mol, DeltaS = -5 (18) J/mol K) are comparable with those of other (C6F5)3B-based adducts. The nature of the intramolecular interactions that result in such energetic barriers is discussed. PMID:16471981

  16. Regioselective Glycosylation of 3-, 5-, 6-, and 7-Hydroxyflavones by Cultured Plant Cells.

    PubMed

    Shimoda, Kei; Kubota, Naoji; Uesugi, Daisuke; Fujitaka, Yuuya; Okada, Shouta; Tanigawa, Masato; Hamada, Hiroki

    2015-06-01

    Regioselective glycosylation of 3-, 5-, 6-, and 7-hydroxyflavones was investigated using cultured plant cells of Eucalyptus perriniana and Phytolacca americana as biocatalysts. 3- and 7-Hydroxyflavones were practically glycosylated into the corresponding β-D-glucosides by E. perriniana and P. americana.

  17. 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists.

    PubMed

    Fabritius, Charles-Henry; Pesonen, Ullamari; Messinger, Josef; Horvath, Raymond; Salo, Harri; Gałęzowski, Michał; Galek, Mariusz; Stefańska, Klaudia; Szeremeta-Spisak, Joanna; Olszak-Płachta, Marta; Buda, Anna; Adamczyk, Justyna; Król, Marcin; Prusis, Peteris; Sieprawska-Lupa, Magdalena; Mikulski, Maciej; Kuokkanen, Katja; Chapman, Hugh; Obuchowicz, Radosław; Korjamo, Timo; Jalava, Niina; Nowak, Mateusz

    2016-06-01

    A series of 1-Sulfonyl-6-Piperazinyl-7-Azaindoles, showing strong antagonistic activity to 5-HT6 receptor (5-HT6R) was synthesized and characterized. The series was optimized to reduce activity on D2 receptor. Based on the selectivity against this off-target and the analysis of the ADME-tox profile, compound 1c was selected for in vivo efficacy assessment, which demonstrated procognitive effects as shown in reversal of scopolamine induced amnesia in an elevated plus maze test in mice. Compound 3, the demethylated version of compound 1c, was profiled against a panel of 106 receptors, channels and transporters, indicating only D3 receptor as a major off-target. Compound 3 has been selected for this study over compound 1c because of the higher 5-HT6R/D2R binding ratio. These results have defined a new direction for the design of our pseudo-selective 5-HT6R antagonists.

  18. High antiallergic activity of 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone and 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone from eau de cologne mint (Mentha×piperita citrata).

    PubMed

    Sato, Akihiko; Tamura, Hirotoshi

    2015-04-01

    The following compounds with higher antiallergic activities were isolated from eau de cologne mint leaves: 5,6,4'-trihydroxy-7,8-dimethoxyflavone (6), 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone (7), 5,6-dihydroxy-7,3',4'-trimethoxyflavone (8), 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone (9), and 5,6-dihydroxy-7,8,4'-trimethoxyflavone (10). The IC50 values of compounds 6-10 against RBL-2H3 cells were 6.7, 2.4, 5.6, 3.0, and 6.1μM. Compounds 7 and 9 (IC50 2.4μM and 3.0μM) had the highest antiallergic activities among the flavonoids previously reported. The amounts of 7, 9, and 10 isolated were fairly high, at 177.7mg/kg, 278.0mg/kg, and 179.7mg/kg in the mint, respectively. LD5 value (index of toxicity) and LD5/IC50 ratio of 7 and 9 indicate that the safety is greater than that of luteolin, a typical antiallergic substance. The extract containing powerful antiallergic flavones, 6-10 with higher hydrophobicity could be selectively separated from the extract containing luteolin and other flavonoid glycosides by partition with dichloromethane and water. Therefore, compounds 7 and 9 in mint, and the dichloromethane extract would be the most potent and preventive resources against type I allergy.

  19. 1,5-Dichloro-3(2,7),7(2,7)-dinaphthal-ena-2,4,6,8-tetra-oxa-1(2,6),5(2,6)-di(1,3,5-triazina)octa-phane.

    PubMed

    Sang, Qiu-Guang; Yang, Jing-Kui

    2011-09-01

    In the macrocyclic title compound, C(26)H(12)Cl(2)N(6)O(4), an O-atom-bridged calix[2]naphthalene-[2]triazine synthesized using a one-pot approach from naphthalene-2,7-diol and cyanuric chloride, the two isolated naphthalene planes and the two triazine-2,6-di-oxy planes adopt a 1,3-alternate configuration, with a dihedral angle of 84.10 (8)° between the naphthalene rings and a dihedral angle of 39.02 (14)° between the triazine rings. In the crystal, weak inter-molecular π-π stacking inter-actions are found between face-to-face naphthalene rings [centroid-centroid distance = 3.662 (7) Å].

  20. Unusual C7- versus Normal 5'-O-Dimethoxytritylation of 6-Arylpyrrolocytidine Analogs.

    PubMed

    Suchý, Mojmír; Ettles, Christie; Wisner, James A; Matarazzo, Augusto; Hudson, Robert H E

    2016-09-16

    Fluorescent deoxynucleosides possessing the modified bases 6-(2-benzo[b]furyl)- and 6-(2-furyl)pyrrolocytosine (BFpC and FpC) have been synthesized along with the quencher nucleosides possessing 6-{4-[(4-dimethylamino)azo]phenyl}pyrrolocytosine (DABCYLpC) and 6-(p-nitrophenyl)pyrrolocytosine (p-NO2-PhpC) nucleobase analogs. Standard treatment of BFpC, FpC, DABCYLpC, and p-NO2-PhpC with dimethoxytrityl chloride (DMT-Cl) led to the unusual substitution on the C7 of the pyrrolocytosine skeleton. The desired 5'-O-DMT-protected nucleoside analogs were synthesized from suitably protected 5'-O-DMT cytidines. Subsequent phosphitylation smoothly afforded BFpC-, FpC-, DABCYLpC-, and p-NO2-PhpC-derived monomers suitable for standard oligonucleotide synthesis. PMID:27529362

  1. Novel synthetic approach to 6,7-dihydro-5H-imidazo[1,5-a]-pyrazin-8-ones.

    PubMed

    Gopalsamy, Ariamala; Shi, Mengxiao

    2003-10-16

    [reaction: see text] A novel route to highly substituted chiral 6,7-dihydro-5H-imidazo[1,5-a]pyrazine-8-ones starting from Meldrum's acid is disclosed. The key features of the methodology are the incorporation of amino esters as a chiral pool and facile mild intramolecular cyclization to form the pyrazine ring. Incorporation of various substituents at different stages of the synthesis from various building block sets makes this methodology readily amenable to parallel synthesis. PMID:14535740

  2. Organocatalyzed enantioselective synthesis of 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylates

    PubMed Central

    Ramireddy, Naresh; Abbaraju, Santhi; Zhao, Cong-Gui

    2011-01-01

    The organocatalyzed enantioselective synthesis of biologically active 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate derivatives was achieved using bifunctional cinchona alkaloids as the catalysts. Using quinine thiourea as the catalyst, the tandem Michael addition-cyclization reaction between 1,3-cyclohexanediones and alkylidenecyanoacetate derivatives gives the desired products in high yields (up to 92%) and good ee values (up to 82%). PMID:22081731

  3. A toxicological study of 5,6,7,8 tetrafluoro- 1,4-benzodioxin

    SciTech Connect

    London, J.E.

    1988-05-01

    The acute oral LD/sub 50/ values for 5,6,7,8 tetrafluro-1,4 benzodioxin for mice and rats are less than 5 gkg. According to classical guidelines, the material is considered slightly toxic in both species. The sensitization study in the guinea pig did not show the material to have potential sensitizing properties. Skin application studies on the rabbit demonstrated that it was cutaneously mildly irritating. This material was very mildly irritating in the rabbit eye application studies. 4 refs., 2 tabs.

  4. Preliminary Focal Mechanism Analysis of the 6 November 2011 M 5.7 Oklahoma sequence

    NASA Astrophysics Data System (ADS)

    Wei, M.; Sumy, D. F.; Cochran, E. S.; Keranen, K. M.; Abers, G. A.; Savage, H. M.

    2012-12-01

    A M5.7 strike-slip earthquake occurred on 6 November 2011 near Prague, Oklahoma and was followed by hundreds of aftershocks in the subsequent months. While earthquakes are not unknown to Oklahoma, seismicity rates in the region have risen steadily since 2008, with increases in both the frequency and intensity of the earthquakes observed. The M5.7 earthquake is the largest quake recorded during this recent period of increased seismicity. Prior to the mainshock, 19 seismometers were located within approximately 100 km of the event. An additional 28 seismometers were temporarily deployed after the mainshock to record the aftershock sequence. We use data collected from these seismometers to calculate the focal mechanisms for a subset of the aftershocks. Here, we examine the 80 largest aftershocks that occur prior to 31 December 2011. P-wave arrivals and polarities are manually identified on the vertical component of each station. Polarities are marked as impulsive or emergent and the pick is given a quality rating (0-4). We then use HASH (Hardebeck and Shearer, 2002) and a 1-D velocity model to calculate the focal mechanisms. For each event, HASH outputs a set of acceptable mechanisms and, based on how clustered the set of acceptable mechanisms is, a quality and uncertainty is assigned. The early aftershock locations suggest that the 5 November 2011 M5.0 foreshock, 6 November 2011 M5.7 mainshock, and the largest (8 November 2011 M5.0) aftershock may have occurred on faults with strikes of 34°, 55°, and 90°, respectively. Given this change in fault strike for the largest events in the sequence, we will investigate whether there is also a systematic variation in the aftershock focal mechanisms with time. We will also investigate spatial variation in focal mechanism type (e.g. strike-slip, normal, or thrust) and inferred fault strike.

  5. 1,5,6-Triphenyl-8-oxa-7-selena-6-phos-phabicyclo-[3.2.1]octane-6-selone.

    PubMed

    Hua, Guoxiong; Li, Yang; Slawin, Alexandra M Z; Woollins, J Derek

    2007-12-06

    The structure of the title compound, C(23)H(21)OPSe(2), consists of fused puckered five- and six-membered rings, PSeC(2)O and C(5)O, respectively, with a C(2)O bridgehead. The C(5)O ring adopts a chair conformation, whilst the C(2)PSeO ring has an envelope conformation.

  6. One-Dimensional σ-MODELS with N = 5, 6, 7, 8 Off-Shell Supersymmetries

    NASA Astrophysics Data System (ADS)

    Gonzales, M.; Rojas, M.; Toppan, F.

    We computed the actions for the one-dimensional (1D) N = 5 σ-models with respect to the two inequivalent (2, 8, 6) multiplets. Four supersymmetry generators are manifest, while the constraint originated by imposing the fifth supersymmetry automatically induces a full N = 8 off-shell invariance. The resulting action coincides in the two cases and corresponds to a conformally flat 2D target satisfying a special geometry of rigid type. To obtain these results we developed a computational method (for Maple 11) which does not require the notion of superfields and is instead based on the nowadays available list of the inequivalent representations of the 1D N-extended supersymmetry. Its application to systematically analyze the σ-models off-shell invariant actions for the remaining N = 5, 6, 7, 8 (k, 8, 8-k) multiplets, as well as for the N>8 representations, only requires more cumbersome computations.

  7. Ligubenzocycloheptanone A, a Novel Tricyclic Butenolide with a 6/7/5 Skeleton from Ligusticum chuanxiong.

    PubMed

    Han, Bing; Zhang, Xu; Feng, Zi-Ming; Jiang, Jian-Shuang; Li, Li; Yang, Ya-Nan; Zhang, Pei-Cheng

    2016-01-01

    Ligubenzocycloheptanone A (1), a novel tricyclic butenolide with a 6/7/5-membered ring skeleton, was isolated from the rhizome of Ligusticum chuanxiong. Its unusual structure was determined using UV, IR, HRESIMS, 1D and 2D NMR data, X-ray diffraction crystallography and by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. 1 possessed a benzocycloheptanone core featuring butyrolactone, which is rarely observed in nature. A possible biosynthetic pathway was proposed. Ligubenzocycloheptanone A showed strong radical scavenging activity with an IC50 value of 2.3 μM. PMID:27461841

  8. Calibration of NOAA-7 AVHRR, GOES-5 and GOES-6 VISSR/VAS solar channels

    NASA Technical Reports Server (NTRS)

    Frouin, R.; Gautier, C.

    1986-01-01

    The NOAA-7, GOES-5 and GOES-6 Visible Infrared Spin Scan Radiometer/Vertical Atmospheric Sounder (VISSR/VAS) solar channels were calibrated. The White Sands Monument area in New Mexico, whose reflectance properties are well known, and space are used as calibration targets. The shortwave reflected terrestrial irradiance that is measured at satellite altitude is computed using a fairly accurate radiative transfer model which accounts for multiple scattering and bidirectional effects. The ground target reflectance and relevant characteristics of the overlying atmosphere are estimated from climatological data and observation at the nearest meteorological sites. The approach is believed to produce accuracies of 8 to 13% depending on the channel considered.

  9. Ligubenzocycloheptanone A, a Novel Tricyclic Butenolide with a 6/7/5 Skeleton from Ligusticum chuanxiong

    PubMed Central

    Han, Bing; Zhang, Xu; Feng, Zi-Ming; Jiang, Jian-Shuang; Li, Li; Yang, Ya-Nan; Zhang, Pei-Cheng

    2016-01-01

    Ligubenzocycloheptanone A (1), a novel tricyclic butenolide with a 6/7/5-membered ring skeleton, was isolated from the rhizome of Ligusticum chuanxiong. Its unusual structure was determined using UV, IR, HRESIMS, 1D and 2D NMR data, X-ray diffraction crystallography and by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. 1 possessed a benzocycloheptanone core featuring butyrolactone, which is rarely observed in nature. A possible biosynthetic pathway was proposed. Ligubenzocycloheptanone A showed strong radical scavenging activity with an IC50 value of 2.3 μM. PMID:27461841

  10. Ligubenzocycloheptanone A, a Novel Tricyclic Butenolide with a 6/7/5 Skeleton from Ligusticum chuanxiong

    NASA Astrophysics Data System (ADS)

    Han, Bing; Zhang, Xu; Feng, Zi-Ming; Jiang, Jian-Shuang; Li, Li; Yang, Ya-Nan; Zhang, Pei-Cheng

    2016-07-01

    Ligubenzocycloheptanone A (1), a novel tricyclic butenolide with a 6/7/5-membered ring skeleton, was isolated from the rhizome of Ligusticum chuanxiong. Its unusual structure was determined using UV, IR, HRESIMS, 1D and 2D NMR data, X-ray diffraction crystallography and by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. 1 possessed a benzocycloheptanone core featuring butyrolactone, which is rarely observed in nature. A possible biosynthetic pathway was proposed. Ligubenzocycloheptanone A showed strong radical scavenging activity with an IC50 value of 2.3 μM.

  11. RELAP5 assessment: LOFT turbine trip L6-7/L9-2

    SciTech Connect

    Thompson, S.L.; Kmetyk, L.N.

    1983-07-01

    The RELAP5 independent assessment project at Sandia National Laboratories is part of an overall effort funded by the NRC to determine the ability of various systems codes to predict the detailed thermal; hydraulic response of LWRs during accident and off-normal conditions. The RELAP5/MOD1 code is being assessed at SNLA against test data from various integral and separate effects test facilities. As part of this assessment matrix, a turbine trip rapid cooldown transient performed at the LOFT test facility has been analyzed. The results show that RELAP5/MOD1 can predict the experimental behavior of LOFT test L6-7/L9-2 in detail. However, careful selection of modeling options and adjustment of boundary conditions within the experimental uncertainties is required.

  12. Synthesis of 5,6-dihydro-4H-benzo[d]isoxazol-7-one and 5,6-dihydro-4H-isoxazolo[5,4-c]pyridin-7-one derivatives as potential Hsp90 inhibitors.

    PubMed

    Musso, Loana; Cincinelli, Raffaella; Giannini, Giuseppe; Manetti, Fabrizio; Dallavalle, Sabrina

    2015-11-01

    A novel class of 5,6-dihydro-4H-benzo[d]isoxazol-7-ones and 5,6-dihydro-4H-isoxazolo[5,4-c]pyridin-7-ones was designed, synthesized, and assayed to investigate the affinity toward Hsp90 protein. The synthetic route was based on a 1,3-dipolar cycloaddition of nitriloxides, generated in situ from suitable benzaldoximes, with 2-bromocyclohex-2-enones or 3-bromo-5,6-dihydro-1H-pyridin-2-ones. Whereas all the compounds bearing a benzamide group on the bicyclic scaffold were devoid of activity, the derivatives carrying a resorcinol-like fragment showed a remarkable inhibitory effect on Hsp90. Docking calculations were performed to investigate the orientation of the new compounds within the binding site of the enzyme.

  13. Synthesis of 5,6-dihydro-4H-benzo[d]isoxazol-7-one and 5,6-dihydro-4H-isoxazolo[5,4-c]pyridin-7-one derivatives as potential Hsp90 inhibitors.

    PubMed

    Musso, Loana; Cincinelli, Raffaella; Giannini, Giuseppe; Manetti, Fabrizio; Dallavalle, Sabrina

    2015-11-01

    A novel class of 5,6-dihydro-4H-benzo[d]isoxazol-7-ones and 5,6-dihydro-4H-isoxazolo[5,4-c]pyridin-7-ones was designed, synthesized, and assayed to investigate the affinity toward Hsp90 protein. The synthetic route was based on a 1,3-dipolar cycloaddition of nitriloxides, generated in situ from suitable benzaldoximes, with 2-bromocyclohex-2-enones or 3-bromo-5,6-dihydro-1H-pyridin-2-ones. Whereas all the compounds bearing a benzamide group on the bicyclic scaffold were devoid of activity, the derivatives carrying a resorcinol-like fragment showed a remarkable inhibitory effect on Hsp90. Docking calculations were performed to investigate the orientation of the new compounds within the binding site of the enzyme. PMID:25855505

  14. Disodium hydrogen citrate sesquihydrate, Na2HC6H5O7(H2O)1.5.

    PubMed

    Rammohan, Alagappa; Sarjeant, Amy A; Kaduk, James A

    2016-07-01

    The crystal structure of disodium hydrogen citrate sesquihydrate, 2Na2 (+)·C6H6O7 (2-)·1.5H2O, has been solved and refined using laboratory X-ray single-crystal diffraction data, and optimized using density functional techniques. The asymmetric unit contains two independent hydrogen citrate anions, four sodium cations and three water molecules. The coordination polyhedra of the cations (three with a coordination number of six, one with seven) share edges to form isolated 8-rings. The un-ionized terminal carb-oxy-lic acid groups form very strong hydrogen bonds to non-coordinating O atoms, with O⋯O distances of 2.46 Å. PMID:27555936

  15. Disodium hydrogen citrate sesquihydrate, Na2HC6H5O7(H2O)1.5

    PubMed Central

    Rammohan, Alagappa; Sarjeant, Amy A.; Kaduk, James A.

    2016-01-01

    The crystal structure of disodium hydrogen citrate sesquihydrate, 2Na2 +·C6H6O7 2−·1.5H2O, has been solved and refined using laboratory X-ray single-crystal diffraction data, and optimized using density functional techniques. The asymmetric unit contains two independent hydrogen citrate anions, four sodium cations and three water molecules. The coordination polyhedra of the cations (three with a coordination number of six, one with seven) share edges to form isolated 8-rings. The un-ionized terminal carb­oxy­lic acid groups form very strong hydrogen bonds to non-coordinating O atoms, with O⋯O distances of 2.46 Å. PMID:27555936

  16. 3,5,5,6,8,8-Hexamethyl-5,6,7,8-tetra­hydro-2-naphthoic acid (AHTN–COOH)

    PubMed Central

    Kuhlich, Paul; Göstl, Robert; Metzinger, Ramona; Piechotta, Christian; Nehls, Irene

    2010-01-01

    The title compound, C17H24O2, is the product of a haloform reaction of 6-acetyl-1,1,2,4,4,7-hexa­methyl­tetra­line (AHTN). The compound is a racemic mixture with a disorder in its aliphatic ring [occupany ratio 0.683 (4):0.317 (4)] due to two possible half-chair forms. The carb­oxy­lic acid unit is slightly twisted out of coplanarity with the aromatic system [dihedral angle = 29.26 (6)°]. In the crystal, pairs of short classical inter­molecular O—H⋯O hydrogen bonds link pairs of mol­ecules around a center of symmetry. PMID:21587655

  17. Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells.

    PubMed

    Mahé, Cécile; Loetscher, Erika; Dev, Kumlesh K; Bobirnac, Ionel; Otten, Uwe; Schoeffter, Philippe

    2005-07-01

    Brain serotonin 5-HT(7) receptors are known to be expressed in neurons and astrocytes. We now report the presence of these receptors in a third type of cell, microglial cells. 5-Hydroxytryptamine (5-HT), 5-carboxamidotryptamine (5-CT), 5-methoxytryptamine (5-MeOT) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) induced concentration-dependent stimulations of cAMP accumulation in the human microglial MC-3 cell line. The maximal effect of 5-HT was 3.4+/-0.3-fold stimulation (mean+/-S.E.M., n=5) above basal levels. The rank order of agonist potency (pEC50 values) was 5-CT (7.09)>5-HT (6.13)>or=5-MeOT (5.78)>8-OH-DPAT (ca. 5). The effect of 5-CT was inhibited in a concentration-dependent manner by the selective 5-HT7 receptor antagonist SB-269970 (pA2 value 9.03). Western blot analysis revealed the presence of immunoreactive bands corresponding to the human 5-HT7 receptor in extracts of MC-3 cells. The presence of two splice variants of the 5-HT7 receptor (5-HT7(a/b)) was visualized by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis with specific primers. In real-time PCR studies, the mRNA for interleukin-6 (IL-6) was found to be increased by 2.5-fold in MC-3 cells after 1 h incubation with 5-CT (1 microM) and this effect was fully blocked by the 5-HT7 receptor antagonist SB-269970 (1 microM). These data show that functional 5-HT7 receptors are present in human microglial MC-3 cells, suggesting that they are involved in neuroinflammatory processes. PMID:15992579

  18. 5,7-Dihydroxy-6-geranylflavanone improves insulin sensitivity through PPARα/γ dual activation.

    PubMed

    Lee, Woojung; Yoon, Goo; Kim, Min Cheol; Kwon, Hak Cheol; Bae, Gyu-Un; Kim, Yong Kee; Kim, Su-Nam

    2016-05-01

    In the present study, we demonstrate that 5,7-dihydroxy-6-geranylflavanone (DGF) isolated from Amorpha fruticosa (A. fruticosa) is a novel peroxisome proliferator-activated receptor (PPAR)α/γ dual agonist which may be used to improve insulin sensitivity. The extract from A. fruticosa increased the transcriptional activity of both PPARα and PPARγ which was, in part, driven by the active ingredient DGF. Treatment with DGF markedly enhanced the adipogenesis of 3T3-L1 preadipocytes, which was comparable to the effect of the PPARγ agonist, troglitazone. In addition, DGF was found to enhance fatty acid oxidation and glucose utilization through the dual activation of PPARα/γ. In addition treatment with DGF led to an improvement in insulin sensitivity, resulting in enhanced glucose uptake in muscle cells. The findings of our study data suggest that DGF may be used as potential therapeutic agent in the treatment of type 2 diabetes and related metabolic disorders by enhancing glucose and lipid metabolism. PMID:26986637

  19. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2013-07-01 2013-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  20. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2012-07-01 2012-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  1. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2014-07-01 2014-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  2. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2010-07-01 2010-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  3. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2011-07-01 2011-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR...

  4. 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase.

    PubMed

    Perner, Richard J; Gu, Yu-Gui; Lee, Chih-Hung; Bayburt, Erol K; McKie, Jeffery; Alexander, Karen M; Kohlhaas, Kathy L; Wismer, Carol T; Mikusa, Joe; Jarvis, Michael F; Kowaluk, Elizabeth A; Bhagwat, Shripad S

    2003-11-20

    The synthesis and structure-activity relationship of a series of 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel nonnucleoside adenosine kinase inhibitors is described. A variety of alkyl, aryl, and heteroaryl substituents were found to be tolerated at the C5, C6, and C7 positions of the pyridopyrimidine core. These studies have led to the identification of analogues that are potent inhibitors of adenosine kinase with in vivo analgesic activity.

  5. Process for manufacturing bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene

    DOEpatents

    Rasmussen, Paul George; Lawton, Richard Graham

    2014-06-03

    A process to manufacture substituted tetracyano-hexaazatricyclics with the substitutions occurring at the 9 and 10 hydrogens. The process begins with 2,3-dichloro-5,6-dicyanopyrazine, which is reacted to form the desired tetracyano-hexaazatricyclic. Different process embodiments enable different reaction paths to the desired tetracyano-hexaazatricyclic. Different tetracyano-hexaazatricyclic embodiments include bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene and bis(2-methoxyethoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracen- e.

  6. Advanced Gas Reactor (AGR)-5/6/7 Fuel Irradiation Experiments in the Advanced Test Reactor

    SciTech Connect

    A. Joseph Palmer; David A. Petti; S. Blaine Grover

    2014-04-01

    The United States Department of Energy’s Very High Temperature Reactor (VHTR) Advanced Gas Reactor (AGR) Fuel Development and Qualification Program will be irradiating up to seven separate low enriched uranium (LEU) tri-isotopic (TRISO) particle fuel (in compact form) experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). These irradiations and fuel development are being accomplished to support development of the next generation reactors in the United States. The goals of the irradiation experiments are to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel performance and fission product transport models and codes, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. The experiments, which each consist of at least five separate capsules, are being irradiated in an inert sweep gas atmosphere with individual on-line temperature monitoring and control of each capsule. The sweep gases also have on-line fission product monitoring the effluent from each capsule to track performance of the fuel during irradiation. The first two experiments (designated AGR-1 and AGR-2), have been completed. The third and fourth experiments have been combined into a single experiment designated AGR-3/4, which started its irradiation in December 2011 and is currently scheduled to be completed in April 2014. The design of the fuel qualification experiment, designated AGR-5/6/7, is well underway and incorporates lessons learned from the three previous experiments. Various design issues will be discussed with particular details related to selection of thermometry.

  7. Accelerations from the September 5, 2012 (Mw=7.6) Nicoya, Costa Rica Earthquake

    NASA Astrophysics Data System (ADS)

    Simila, G. W.; Quintero, R.; Burgoa, B.; Mohammadebrahim, E.; Segura, J.

    2013-05-01

    Since 1984, the Seismic Network of the Volcanological and Seismological Observatory of Costa Rica, Universidad Nacional (OVSICORI-UNA) has been recording and registering the seismicity in Costa Rica. Before September 2012, the earthquakes registered by this seismic network in northwestern Costa Rica were moderate to small, except the Cóbano earthquake of March 25, 1990, 13:23, Mw 7.3, lat. 9.648, long. 84.913, depth 20 km; a subduction quake at the entrance of the Gulf of Nicoya and generated peak intensities in the range of MM = VIII near the epicentral area and VI-VII in the Central Valley of Costa Rica. Six years before the installation of the seismic network, OVSICORI-UNA registered two subduction earthquakes in northwestern Costa Rica, specifically on August 23, 1978, at 00:38:32 and 00:50:29 with magnitudes Mw 7.0 (HRVD), Ms 7.0 (ISC) and depths of 58 and 69 km, respectively (EHB Bulletin). On September 5, 2012, at 14:42:02.8 UTC, the seismic network OVSICORI-UNA registered another large subduction earthquake in Nicoya peninsula, northwestern Costa Rica, located 29 km south of Samara, with a depth of 21 km and magnitude Mw 7.6, lat. 9.6392, long. 85.6167. This earthquake was caused by the subduction of the Cocos plate under the Caribbean plate in northwestern Costa Rica. This earthquake was felt throughout the country and also in much of Nicaragua. The instrumental intensity map for the Nicoya earthquake indicates that the earthquake was felt with an intensity of VII-VIII in the Puntarenas and Nicoya Peninsulas, in an area between Liberia, Cañas, Puntarenas, Cabo Blanco, Carrillo, Garza, Sardinal, and Tamarindo in Guanacaste; Nicoya city being the place where the maximum reported intensity of VIII is most notable. An intensity of VIII indicates that damage estimates are moderate to severe, and intensity VII indicates that damage estimates are moderate. According to the National Emergency Commission of Costa Rica, 371 affected communities were reported; most

  8. The Lyα luminosity function at z = 5.7 - 6.6 and the steep drop of the faint end: implications for reionization

    NASA Astrophysics Data System (ADS)

    Santos, Sérgio; Sobral, David; Matthee, Jorryt

    2016-08-01

    We present new results from the widest narrow band survey search for Lyα emitters at z = 5.7, just after reionization. We survey a total of 7 deg2 spread over the COSMOS, UDS and SA22 fields. We find over 11,000 line emitters, out of which 514 are robust Lyα candidates at z = 5.7 within a volume of 6.3 × 106 Mpc3. Our Lyα emitters span a wide range in Lyα luminosities, from faint to bright (LLyα ˜ 1042.5 - 44 erg s-1) and rest-frame equivalent widths (EW0 ˜ 25 - 1000 Å) in a single, homogeneous data-set. By combining all our fields we find that the faint end slope of the z = 5.7 Lyα luminosity function is very steep, with α =-2.3^{+0.4}_{-0.3}. We also present an updated z = 6.6 Lyα luminosity function, based on comparable volumes and obtained with the same methods, which we directly compare with that at z = 5.7. We find a significant decline of the number density of faint Lyα emitters from z = 5.7 to z = 6.6 (by 0.5 ± 0.1 dex), but no evolution at the bright end/no evolution in L★. Faint Lyα emitters at z = 6.6 show much more extended haloes than those at z = 5.7, suggesting that neutral Hydrogen plays an important role, increasing the scattering and leading to observations missing faint Lyα emission within the epoch of reionization. All together, our results suggest that we are observing patchy reionization which happens first around the brightest Lyα emitters, allowing the number densities of those sources to remain unaffected by the increase of neutral Hydrogen fraction from z ˜ 5 to z ˜ 7.

  9. The Petrographic Analysis of Yucatan Shelf Sequence in UNAM-5, 6 and 7 Wells

    NASA Astrophysics Data System (ADS)

    Nieto, A. O.; Fucugauchi, J. U.

    2013-05-01

    We present the initial results of a stratigraphic, X-ray diffraction and petrographic study of the Cenozoic carbonate sequence in the Yucatan's shelf. The sequence is studied in cores from the UNAM-5, UNAM-6 and UNAM-7 boreholes, which are located in the southwest and southern sectors of the Yucatan state, close to the Ticul Sierra. The Yucatán shelf is an area of scientific interest because beneath the Cenozoic sedimentary deposits there is crater impact of 180-200 km diameter, which formed 65.5 Ma ago. The Yucatan shelf has been characterized to be a shallow ramp shelf that is tectonically stable and has a Cenozoic continuous sedimentary record. With the aim of investigating the nature, stratigraphic relations, textural changes and identify possible events that occurred along the Cenozoic record. Using macroscopic descriptions, we performed detailed stratigraphic columns for the three borehole cores and prepared samples collected across stratigraphic columns for the petrography and the clays identification. The petrographic studies were made at different depths above the K/Pg boundary and whit the aim of recognize the textural variations, and the skeletal content, the identification of dolomite was made by the method of staining thin sections. Analysis of microfacies associations followed the criteria in facies belts Wilson 1975 for carbonate rimmed platforms, using and comparing, while the ramp carbonate microfacies type of Flügel 2009 to homoclinal carbonate ramp platform. The method of X-ray diffraction was used to identify clay types. Three boreholes contain the K/Pg boundary at different depths that correspond to a sequence, from bottom to top of limestone with evaporites nodules, clay content identified as illite-esmectite, little content of benthic, scarce planktic foraminifera and oogonia fossils that correspond to lagoon zone. This sequence is underlying limestones with different degrees of dolomitization that in many cases destroyed all fossils

  10. E5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation.

    PubMed

    Al Moustafa, Ala-Eddin

    2015-01-01

    It is estimated that 10-20% of human carcinogenesis is linked to virus infection including papillomaviruses (HPVs). Moreover, since metastatic cancer disease is a major cause of morbidity and mortality in cancer patients, the role of onco-viruses in cancer progression to a metastatic form is of particular interest. Recent studies reported that E5 and E6/E7 onco-proteins of high-risk HPVs could enhance cancer progression via the initiation of the epithelial-mesenchymal transition (EMT) event. Herein, we discuss the association between E5 as well as E6/E7 of high-risk HPV and cancer progression. PMID:26177717

  11. Ring Puckering Potentials of Three Fluorinated Cyclopentenes: C_5F_8, C_5HF_7, and C_5H_2F_6

    NASA Astrophysics Data System (ADS)

    Arsenault, E. A.; Long, B. E.; Pringle, Wallace C.; Choi, Yoon Jeong; Cooke, S. A.; Ocola, Esther J.; Laane, Jaan

    2015-06-01

    A systematic study on the ring puckering potentials of three fluorinated cyclopentenes has been performed using Fourier transform microwave spectroscopy in tandem with quantum chemical calculations. Spectra between 8 GHz and 16 GHz have been measured for octafluorocyclopentene, 1H-heptafluorocyclopentene, and 1H,2H-hexafluorocyclopentene, where the hydrogens sequentially replace the fluorines on the sp^2 hybridized carbons. Rotational constants and centrifugal distortion constants have been determined for the parent species and all 13C isotopologues. In regards to the ring puckering, double minimum potential, both cross state and intra-state transitions were observed for all molecules except the 1H,2H-hexafluorocyclopentene. Experimental Coriolis coupling constants and ΔE01 values will be presented and discussed. The ring puckering barrier heights for C_5F_8, C_5HF_7, and C_5H_2F_6, have been calculated to be 222 wn, 302 wn, and 367 wn, respectively.

  12. 21 CFR 73.3119 - 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone. 73.3119 Section 73.3119 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3119...

  13. 21 CFR 73.3119 - 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone. 73.3119 Section 73.3119 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3119...

  14. 21 CFR 73.3119 - 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone. 73.3119 Section 73.3119 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3119...

  15. PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels.

    PubMed

    Itsuki, Kyohei; Imai, Yuko; Hase, Hideharu; Okamura, Yasushi; Inoue, Ryuji; Mori, Masayuki X

    2014-02-01

    Transient receptor potential classical (or canonical) (TRPC)3, TRPC6, and TRPC7 are a subfamily of TRPC channels activated by diacylglycerol (DAG) produced through the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) by phospholipase C (PLC). PI(4,5)P2 depletion by a heterologously expressed phosphatase inhibits TRPC3, TRPC6, and TRPC7 activity independently of DAG; however, the physiological role of PI(4,5)P2 reduction on channel activity remains unclear. We used Förster resonance energy transfer (FRET) to measure PI(4,5)P2 or DAG dynamics concurrently with TRPC6 or TRPC7 currents after agonist stimulation of receptors that couple to Gq and thereby activate PLC. Measurements made at different levels of receptor activation revealed a correlation between the kinetics of PI(4,5)P2 reduction and those of receptor-operated TRPC6 and TRPC7 current activation and inactivation. In contrast, DAG production correlated with channel activation but not inactivation; moreover, the time course of channel inactivation was unchanged in protein kinase C-insensitive mutants. These results suggest that inactivation of receptor-operated TRPC currents is primarily mediated by the dissociation of PI(4,5)P2. We determined the functional dissociation constant of PI(4,5)P2 to TRPC channels using FRET of the PLCδ Pleckstrin homology domain (PHd), which binds PI(4,5)P2, and used this constant to fit our experimental data to a model in which channel gating is controlled by PI(4,5)P2 and DAG. This model predicted similar FRET dynamics of the PHd to measured FRET in either human embryonic kidney cells or smooth muscle cells, whereas a model lacking PI(4,5)P2 regulation failed to reproduce the experimental data, confirming the inhibitory role of PI(4,5)P2 depletion on TRPC currents. Our model also explains various PLC-dependent characteristics of channel activity, including limitation of maximum open probability, shortening of the peak time, and the bell-shaped response of total

  16. Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence.

    PubMed

    Li, Cecilia; Lev, Sophie; Saiardi, Adolfo; Desmarini, Desmarini; Sorrell, Tania C; Djordjevic, Julianne T

    2016-01-01

    Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans. Cryptococcal Kcs1 converts IP6 to PP-IP5/IP7, but the kinase converting IP5 to IP6 is unknown. Deletion of a putative IP5 kinase-encoding gene (IPK1) alone (ipk1Δ), and in combination with KCS1 (ipk1Δkcs1Δ), profoundly reduced virulence in mice. However, deletion of KCS1 and IPK1 had a greater impact on virulence attenuation than that of IPK1 alone. ipk1Δkcs1Δ and kcs1Δ lung burdens were also lower than those of ipk1Δ. Unlike ipk1Δ, ipk1Δkcs1Δ and kcs1Δ failed to disseminate to the brain. IP profiling confirmed Ipk1 as the major IP5 kinase in C. neoformans: ipk1Δ produced no IP6 or PP-IP5/IP7 and, in contrast to ipk1Δkcs1Δ, accumulated IP5 and its pyrophosphorylated PP-IP4 derivative. Kcs1 is therefore a dual specificity (IP5 and IP6) kinase producing PP-IP4 and PP-IP5/IP7. All mutants were similarly attenuated in virulence phenotypes including laccase, urease and growth under oxidative/nitrosative stress. Alternative carbon source utilisation was also reduced significantly in all mutants except ipk1Δ, suggesting that PP-IP4 partially compensates for absent PP-IP5/IP7 in ipk1Δ grown under this condition. In conclusion, PP-IP5/IP7, not IP6, is essential for fungal virulence. PMID:27033523

  17. Reactions of vitamin E and its model compound 2,2,5,7,8-pentamethylchroman-6-ol with ozone

    SciTech Connect

    Liebler, D.C.; Matsumoto, Shigenobu; Matsuo, Mitsuyoshi; Iitaka, Yoichi

    1993-01-01

    Reaction of vitamin E [(R,R,R,)-{alpha}-tocopherol] with ozone in acetonitrile yielded {alpha}-tocopheryl quinone and its precursor 8{alpha}-hydroxytocopherone, which accounted for approximately 30% of the products at <50% {alpha}-tocopherol oxidation. In addition, two novel products were identified as epimers of 10-acetyl-7-(4{prime},8{prime},12{prime}-trimethyl tridecyl)-3,4,7-trimethyl-2-oxo - 1,6-dioxaspiro[4.5]-deca-3,9-diene. These spiro products were formed in equal amounts in a combined yield of approximately 33% after complete {alpha}-tocpherol oxidation. Ozonation of the vitamin E model compound 2,2,5,7,8-pentamethylchroman-6-ol yielded an analogous spiro product, 10-acetyl-3,4,7,7-tetramethyl-2-oxo-1,6-dioxaspiro[4.5]deca-3,9-diene, whose structure was confirmed by X-ray crystallography. The spiro products may be formed by ozone addition to the chroman ring and subsequent rearrangement to ring-opened hydroxyacid products, which yield spiro products by ring closure due to dehydration. Novel spiro products formed by ozonation of vitamin E may be unique markers of ozone interaction with lipid structures that contain vitamin E. 39 refs., 3 figs., 1 tab.

  18. 5,6-de-epoxy-5-en-7-one-17-hydroxy withaferin A, a new cytotoxic steroid from Withania somnifera L. Dunal leaves.

    PubMed

    Siddique, Amreen A; Joshi, Pallavi; Misra, Laxminarain; Sangwan, Neelam S; Darokar, Mahendra P

    2014-01-01

    From the leaves of Withania somnifera L. Dunal, a new withasteroid named as 5,6-de-epoxy-5-en-7-one-17-hydroxy withaferin A (6) was isolated along with several known compounds, namely 16β-acetoxy-6α,7α-epoxy-5α-hydroxy-1-oxowitha-2,17(20),24-trienolide (1), withanone (2), 16-en-27-deoxy withaferin A (3), 27-deoxy withaferin A (4), withaferin A (5), withanolide D (7) and 27-hydroxy withanone (8). Its structure was determined using spectroscopic methods, namely IR, (1)H NMR, (13)C NMR, COSY, HMBC and HRMS. Among the known compounds, 16β-acetoxy-6α,7α-epoxy-5α-hydroxy-1-oxowitha-2,17(20),24-trienolide (1) was previously reported from the roots of W. somnifera. Now, it has been isolated from the leaves, as well. The cytotoxic activity of the new steroid was carried out using the MTT assay against a panel of cancer cell lines, namely MCF-7 (breast), WRL-68 (liver), PC-3 (prostate) and CACO-2 (colon). The results showed that the new compound possesses strong cytotoxic activity against liver and breast cancer with an IC50 of 1.0 μg/mL and a moderate activity against colon (IC50 3.4 μg/mL) and prostate (IC50 7.4 μg/mL) cancer cells.

  19. 1,3,4,6,7,9-Hexamethylbenzo[1,2-c:3,4-c':5,6-c'']trithiophene: a twisted heteroarene.

    PubMed

    Wu, Yao-Ting; Tai, Chia-Cheng; Lin, Wei-Chih; Baldridge, Kim K

    2009-07-01

    1,3,4,6,7,9-Hexamethylbenzo[1,2-c:3,4-c':5,6-c'']trithiophene (C-Me) was prepared by palladium-catalyzed methylations of the corresponding hexabromide C-Br. The twisted structure of C-Me has been confirmed by X-ray crystal analysis. The physical properties of twisted C-Me and planar benzo[1,2-c:3,4-c':5,6-c'']trithiophene (C-H) were studied and compared. Crystal structures are compared to computational structures determined using density functional theory, with both the M06-2X and B3PW91 functionals.

  20. Genomic and Functional Analyses of Rhodococcus equi Phages ReqiPepy6, ReqiPoco6, ReqiPine5, and ReqiDocB7

    PubMed Central

    Summer, E. J.; Liu, M.; Gill, J. J.; Grant, M.; Chan-Cortes, T. N.; Ferguson, L.; Janes, C.; Lange, K.; Bertoli, M.; Moore, C.; Orchard, R. C.; Cohen, N. D.; Young, R.

    2011-01-01

    The isolation and results of genomic and functional analyses of Rhodococcus equi phages ReqiPepy6, ReqiDocB7, ReqiPine5, and ReqiPoco6 (hereafter referred to as Pepy6, DocB7, Pine5, and Poco6, respectively) are reported. Two phages, Pepy6 and Poco6, more than 75% identical, exhibited genome organization and protein sequence likeness to Lactococcus lactis phage 1706 and clostridial prophage elements. An unusually high fraction, 27%, of Pepy6 and Poco6 proteins were predicted to possess at least one transmembrane domain, a value much higher than the average of 8.5% transmembrane domain-containing proteins determined from a data set of 36,324 phage protein entries. Genome organization and protein sequence comparisons place phage Pine5 as the first nonmycobacteriophage member of the large Rosebush cluster. DocB7, which had the broadest host range among the four isolates, was not closely related to any phage or prophage in the database, and only 23 of 105 predicted encoded proteins could be assigned a functional annotation. Because of the relationship of Rhodococcus to Mycobacterium, it was anticipated that these phages should exhibit some of the features characteristic of mycobacteriophages. Traits that were identified as shared by the Rhodococcus phages and mycobacteriophages include the prevalent long-tailed morphology and the presence of genes encoding LysB-like mycolate-hydrolyzing lysis proteins. Application of DocB7 lysates to soils amended with a host strain of R. equi reduced recoverable bacterial CFU, suggesting that phage may be useful in limiting R. equi load in the environment while foals are susceptible to infection. PMID:21097585

  1. Design, Synthesis and Biological Evaluation of 5-Oxo-1,4,5,6,7,8 Hexahydroquinoline Derivatives as Selective Cyclooxygenase-2 Inhibitors

    PubMed Central

    Zarghi, Afshin; Sabakhi, Iman; Topuzyan, Vigen; Hajimahdi, Zahra; Daraie, Bahram

    2014-01-01

    A group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a COX-2 SO2Me pharmacophore at the para position of the C-2 or C-4 phenyl ring, in conjunction with a C-4 or C-2 phenyl (4-H) or substituted-phenyl ring (4-F,4-Cl,4-Br,4-OMe,4-Me, 4-NO2), were designed for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors. These target 5-oxo-1,4,5,6,7,8 hexahydroquinolines were synthesized via a Hansch condensation reaction. In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 7,8-dihydro- 7,7-dimethyl-2-(4-methoxyphenyl)-4-(4-(methylsulfonyl)phenyl)quinolin-5(1H,4H,6H)- one (9c) as a potent COX-2 inhibitor (IC50 = 0.17 M) with a high COX-2 selectivity index (S.I. = 97.6) comparable to the reference drug celecoxib (COX-2 IC50 = 0.05 mM; COX-2 S.I= 405). A molecular modeling study where 9c was docked in active site of COX-2 showed that the p-SO2Me substituent on the C-2 phenyl ring is inserted into the secondary COX-2 binding site. The structure activity data acquired indicate that the position of the COX-2 SO2Me pharmacophore and type of substituent are important for COX-2 inhibitory activity. PMID:24711830

  2. 3,3,6,6,9,9-Hexaethyl-1,2,4,5,7,8-hexaoxacyclononane at 296 K.

    PubMed

    Cerna, Jorge; Bernès, Sylvain; Cañizo, Adriana; Eyler, Nora

    2009-11-01

    The title molecule (diethyl ketone triperoxide, DEKTP), C(15)H(30)O(6), is a cyclic triperoxide closely related to triacetone triperoxide (TATP), one of the most unstable explosives known. However, the stability of DEKTP is ca 20-50 times greater than that of TATP. DEKTP crystallizes with two molecules in the asymmetric unit, with virtually identical geometry. The cyclononane core is stabilized in a twisted boat-chair conformation (approximate D(3) symmetry), very close to that previously described for TATP. The explanation for the safe thermal behaviour of DEKTP compared with TATP should thus not be sought in the molecular dimensions, but rather in the thermal decomposition kinetics. PMID:19893236

  3. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H{sub 2} hydrogenation reaction network.

  4. Euphorikanin A, a Diterpenoid Lactone with a Fused 5/6/7/3 Ring System from Euphorbia kansui.

    PubMed

    Fei, Dong-Qing; Dong, Le-Le; Qi, Feng-Ming; Fan, Gai-Xia; Li, Hui-Hong; Li, Zheng-Yu; Zhang, Zhan-Xin

    2016-06-17

    Euphorikanin A (1), an unprecedented diterpenoid lactone which possesses a novel 5/6/7/3-fused tetracyclic ring skeleton, was isolated from the roots of Euphorbia kansui. The chemical structure and absolute stereochemistry were elucidated on the basis of extensive spectroscopic methods and single-crystal X-ray diffraction analysis. Compound 1 exhibited moderate cytotoxicity against two human tumor cell lines HeLa and NCI-446. A proposed biosynthetic pathway of compound 1 is also described. PMID:27230557

  5. Phase relations in the K 2W 2O 7-K 2WO 4-KPO 3-Bi 2O 3 system and structure of K 6.5Bi 2.5W 4P 6O 34

    NASA Astrophysics Data System (ADS)

    Terebilenko, K. V.; Zatovsky, I. V.; Baumer, V. N.; Ogorodnyk, I. V.; Slobodyanik, N. S.; Shishkin, O. V.

    2008-09-01

    The phase relations in the cross-section of the K 2W 2O 7-K 2WO 4-KPO 3 containing 15 mol% Bi 2O 3 were undertaken using flux method. Crystallization fields of K 6.5Bi 2.5W 4P 6O 34, K 2Bi(PO 4)(WO 4), Bi 2WO 6, KBi(WO 4) 2 and their cocrystallization areas were identified. Novel phase K 6.5Bi 2.5W 4P 6O 34 was characterized by single-crystal X-ray diffraction: sp. gr. P-1, a=9.4170(5), b=9.7166(4), c=17.6050(7) Å, α=90.052(5)°, β=103.880(5)° and γ=90.125(5)°. It has a layered structure, which contains {K 7Bi 5W 8P 12O 68} ∞ layers stacked parallel to ab plane and sheets composed by potassium atoms separating these layers. Sandwich-like {K 7Bi 5W 8P 12O 68} ∞ layers are assembled from [W 2P 2O 13] ∞ and [BiPO 4] ∞ building units, and are penetrated by tunnels with K/Bi atoms inside. FTIR-spectra of K 2Bi(PO 4)(WO 4) and K 6.5Bi 2.5W 4P 6O 34 were discussed on the basis of factor group theory.

  6. Reduced Condensing and Ordering Effects by 7-Ketocholesterol and 5β,6β-Epoxycholesterol on DPPC Monolayers.

    PubMed

    Telesford, Dana-Marie; Verreault, Dominique; Reick-Mitrisin, Victoria; Allen, Heather C

    2015-09-15

    The exposure of organic-coated marine aerosols containing cholesterol (Chol) to radiation and/or an oxidizing atmosphere results in the formation of oxidized derivatives or oxysterols and will likely change aerosol surface properties. However, the intermolecular interactions between oxysterols and other lipid components and their influence on the surface properties of marine aerosols are not well-known. To address this question, the interfacial behavior and domain morphology of model Langmuir monolayers of two ring-substituted oxysterols, 7-ketocholesterol (7-KChol) and 5β,6β-epoxycholesterol (5,6β-EChol), mixed with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were investigated by means of compression isotherms and Brewster angle microscopy (BAM) over a broad range of surface pressures and sterol molar ratios. Mixed DPPC/cholesterol (Chol) monolayers were also measured for comparison. The results of compression experiments showed that the condensing effect induced on mixed DPPC/sterol monolayers at low surface pressures and for intermediate molar ratios (0.3 ≤ X(sterol) ≤ 0.7) was weaker for oxysterols than for Chol. Additionally, mixed DPPC/oxysterol monolayers exhibited markedly smaller (∼2-3-fold) interfacial rigidity. Examination of the excess free energy of mixing further revealed that DPPC monolayers containing 7-KChol and Chol were thermodynamically more stable at high surface pressures than those with 5,6β-EChol, indicating that the strength of interactions between DPPC and 5,6β-EChol was the smallest. Finally, BAM images in the LE-LC phase of DPPC revealed that in comparison to Chol the addition of small amounts of oxysterols results in larger and less numerous domains, showing that oxysterols are not as effective in fluidizing the condensed phase of DPPC. Taken together, these results suggest that the strength of van der Waals interactions of DPPC alkyl chains with sterols follows the sterol hydrophobicity, with Chol being the most

  7. Magic wavelengths for the 7s1/2-6d3/2,5/2 transitions in Ra+

    NASA Astrophysics Data System (ADS)

    Wu, Xiao-Mei; Li, Cheng-Bin; Tang, Yong-Bo; Shi, Ting-Yun

    2016-09-01

    The dynamic polarizabilities of the 7s and 6d states of Ra+ are calculated using a relativistic core polarization potential method. The magic wavelengths of the 7s1/2-6d3/2,5/2 transitions are identified. Comparing to the common radio-frequency (RF) ion traps, using the laser field at the magic wavelength to trap the ion could suppress the frequency uncertainty caused by the micromotion of the ion, and would not affect the transition frequency measurements. The heating rates of the ion and the powers of the laser for the ion trapping are estimated, which would benefit the possible precision measurements based on all-optical trapped Ra+. Project supported by the National Basic Research Program of China (Grant No. 2012CB821305) and the National Natural Science Foundation of China (Grant Nos. 91336211 and 11504094).

  8. Magic wavelengths for the 7s1/2‑6d3/2,5/2 transitions in Ra+

    NASA Astrophysics Data System (ADS)

    Wu, Xiao-Mei; Li, Cheng-Bin; Tang, Yong-Bo; Shi, Ting-Yun

    2016-09-01

    The dynamic polarizabilities of the 7s and 6d states of Ra+ are calculated using a relativistic core polarization potential method. The magic wavelengths of the 7s1/2‑6d3/2,5/2 transitions are identified. Comparing to the common radio-frequency (RF) ion traps, using the laser field at the magic wavelength to trap the ion could suppress the frequency uncertainty caused by the micromotion of the ion, and would not affect the transition frequency measurements. The heating rates of the ion and the powers of the laser for the ion trapping are estimated, which would benefit the possible precision measurements based on all-optical trapped Ra+. Project supported by the National Basic Research Program of China (Grant No. 2012CB821305) and the National Natural Science Foundation of China (Grant Nos. 91336211 and 11504094).

  9. Meetings of the American Indian Policy Review Commission (January 6, 7, February 4 and 5, 1977). Volume 5.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Select Committee on Indian Affairs.

    The meetings of the American Indian Policy Review Commission on January 6, 1977, were concerned with the markup of the first draft of the final report, the status of the Commission extension, training, distribution of task force reports, and transition coordination. The session on February 4 opened with the announcement that the Senate had passed…

  10. Cytotoxic, Antiproliferative and Pro-Apoptotic Effects of 5-Hydroxyl-6,7,3′,4′,5′-Pentamethoxyflavone Isolated from Lantana ukambensis

    PubMed Central

    Sawadogo, Wamtinga Richard; Cerella, Claudia; Al-Mourabit, Ali; Moriou, Céline; Teiten, Marie-Hélène; Guissou, Innocent Pierre; Dicato, Mario; Diederich, Marc

    2015-01-01

    Lantana ukambensis (Vatke) Verdc. is an African food and medicinal plant. Its red fruits are eaten and highly appreciated by the rural population. This plant was extensively used in African folk medicinal traditions to treat chronic wounds but also as anti-leishmanial or cytotoxic remedies, especially in Burkina Faso, Tanzania, Kenya, or Ethiopia. This study investigates the in vitro bioactivity of polymethoxyflavones extracted from a L. ukambensis as anti-proliferative and pro-apoptotic agents. We isolated two known polymethoxyflavones, 5,6,7,3′,4′,5′-hexamethoxyflavone (1) and 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) from the whole plant of L. ukambensis. Their chemical structures were determined by spectroscopic analysis and comparison with published data. These molecules were tested for the anti-proliferative, cytotoxic and pro-apoptotic effects on human cancer cells. Among them, 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) was selectively cytotoxic against monocytic lymphoma (U937), acute T cell leukemia (Jurkat), and chronic myelogenous leukemia (K562) cell lines, but not against peripheral blood mononuclear cells (PBMCs) from healthy donors, at all tested concentrations. Moreover, this compound exhibited significant anti-proliferative and pro-apoptotic effects against U937 acute myelogenous leukemia cells. This study highlights the anti-proliferative and pro-apoptotic effects of 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) and provides a scientific basis of traditional use of L. ukambensis. PMID:26690473

  11. Passive standoff detection of SF6 at a distance of 5.7 km by differential Fourier transform infrared radiometry.

    PubMed

    Lavoie, Hugo; Puckrin, Eldon; Thériault, Jean-Marc; Bouffard, François

    2005-10-01

    Recent results are presented on the passive detection, identification, and quantification of a vapor cloud of SF6 measured at a horizontal standoff distance of 5.7 km using a dual-beam interferometer optimized for background signal suppression. The measurements were performed at Defense Research and Development Canada (DRDC)-Valcartier during a number of recent open-air experiments. The measurement approach is based on the differential passive standoff detection method that has been developed by DRDC Valcartier during the past few years. This work represents the first such measurement reported in the open literature for a standoff distance as large as 5.7 km. These results clearly demonstrate the capability of the differential radiometry approach to the detection, identification, and quantification of chemical vapor clouds located at long distances from the sensor. PMID:16274529

  12. Passive standoff detection of SF6 at a distance of 5.7 km by differential Fourier transform infrared radiometry.

    PubMed

    Lavoie, Hugo; Puckrin, Eldon; Thériault, Jean-Marc; Bouffard, François

    2005-10-01

    Recent results are presented on the passive detection, identification, and quantification of a vapor cloud of SF6 measured at a horizontal standoff distance of 5.7 km using a dual-beam interferometer optimized for background signal suppression. The measurements were performed at Defense Research and Development Canada (DRDC)-Valcartier during a number of recent open-air experiments. The measurement approach is based on the differential passive standoff detection method that has been developed by DRDC Valcartier during the past few years. This work represents the first such measurement reported in the open literature for a standoff distance as large as 5.7 km. These results clearly demonstrate the capability of the differential radiometry approach to the detection, identification, and quantification of chemical vapor clouds located at long distances from the sensor.

  13. The Identification of Z-dropouts in Pan-STARRS1: Three Quasars at 6.5< z< 6.7

    NASA Astrophysics Data System (ADS)

    Venemans, B. P.; Bañados, E.; Decarli, R.; Farina, E. P.; Walter, F.; Chambers, K. C.; Fan, X.; Rix, H.-W.; Schlafly, E.; McMahon, R. G.; Simcoe, R.; Stern, D.; Burgett, W. S.; Draper, P. W.; Flewelling, H.; Hodapp, K. W.; Kaiser, N.; Magnier, E. A.; Metcalfe, N.; Morgan, J. S.; Price, P. A.; Tonry, J. L.; Waters, C.; AlSayyad, Y.; Banerji, M.; Chen, S. S.; González-Solares, E. A.; Greiner, J.; Mazzucchelli, C.; McGreer, I.; Miller, D. R.; Reed, S.; Sullivan, P. W.

    2015-03-01

    Luminous distant quasars are unique probes of the high-redshift intergalactic medium (IGM) and of the growth of massive galaxies and black holes in the early universe. Absorption due to neutral hydrogen in the IGM makes quasars beyond a redshift of z≃ 6.5 very faint in the optical z band, thus locating quasars at higher redshifts requires large surveys that are sensitive above 1 micron. We report the discovery of three new z\\gt 6.5 quasars, corresponding to an age of the universe of \\lt 850 Myr, selected as z-band dropouts in the Pan-STARRS1 survey. This increases the number of known z\\gt 6.5 quasars from four to seven. The quasars have redshifts of z = 6.50, 6.52, and 6.66, and include the brightest z-dropout quasar reported to date, PSO J036.5078 + 03.0498 with {{M}1450}=-27.4. We obtained near-infrared spectroscopy for the quasars, and from the Mg ii line, we estimate that the central black holes have masses between 5 × 108 and 4 × 109 {{M}⊙ } and are accreting close to the Eddington limit ({{L}Bol}/{{L}Edd}=0.13-1.2). We investigate the ionized regions around the quasars and find near-zone radii of {{R}NZ}=1.5-5.2 proper Mpc, confirming the trend of decreasing near-zone sizes with increasing redshift found for quasars at 5.7\\lt z\\lt 6.4. By combining RNZ of the PS1 quasars with those of 5.7\\lt z\\lt 7.1 quasars in the literature, we derive a luminosity-corrected redshift evolution of {{R}NZ,corrected}=(7.2+/- 0.2)-(6.1+/- 0.7)× (z-6) Mpc. However, the large spread in RNZ in the new quasars implies a wide range in quasar ages and/or a large variation in the neutral hydrogen fraction along different lines of sight. Based in part on observations collected at the European Southern Observatory, Chile, programs 179.A-2010, 092.A-0150, 093.A-0863, and 093.A-0574, and at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC). This paper

  14. A new one-dimensional coordination polymer of 5-(1,3-dioxo-4,5,6,7-tetraphenylisoindolin-2-yl)isophthalic acid with manganese.

    PubMed

    Wang, Jing; Jia, Chunmei; Feng, Xiao; Yuan, Wenbing

    2015-09-01

    The coordination polymer catena-poly[[(dimethylformamide-κO)[μ3-5-(1,3-dioxo-4,5,6,7-tetraphenylisoindolin-2-yl)isophthalato-κ(4)O(1),O(1'):O(3):O(3')](methanol-κO)manganese(III)] dimethylformamide monosolvate], {[Mn(C40H23NO6)(CH3OH)(C3H7NO)]·C3H7NO}n, has been synthesized from the reaction of 5-(1,3-dioxo-4,5,6,7-tetraphenylisoindolin-2-yl)isophthalic acid and manganese(II) acetate tetrahydrate in a glass tube at room temperature by solvent diffusion. The Mn(II) centre is hexacoordinated by two O atoms from one chelating carboxylate group, by two O atoms from two monodentate carboxylate groups and by one O atom each from a methanol and a dimethylformamide (DMF) ligand. The single-crystal structure crystallizes in the triclinic space group P\\overline{1}. Moreover, the coordination polymer shows one-dimensional 2-connected {0} uninodal chain networks, and free DMF molecules are connected to the chains by O-H···O hydrogen bonds. The thermogravimetric and photoluminescent properties of the compound have also been investigated.

  15. A new one-dimensional coordination polymer of 5-(1,3-dioxo-4,5,6,7-tetraphenylisoindolin-2-yl)isophthalic acid with manganese.

    PubMed

    Wang, Jing; Jia, Chunmei; Feng, Xiao; Yuan, Wenbing

    2015-09-01

    The coordination polymer catena-poly[[(dimethylformamide-κO)[μ3-5-(1,3-dioxo-4,5,6,7-tetraphenylisoindolin-2-yl)isophthalato-κ(4)O(1),O(1'):O(3):O(3')](methanol-κO)manganese(III)] dimethylformamide monosolvate], {[Mn(C40H23NO6)(CH3OH)(C3H7NO)]·C3H7NO}n, has been synthesized from the reaction of 5-(1,3-dioxo-4,5,6,7-tetraphenylisoindolin-2-yl)isophthalic acid and manganese(II) acetate tetrahydrate in a glass tube at room temperature by solvent diffusion. The Mn(II) centre is hexacoordinated by two O atoms from one chelating carboxylate group, by two O atoms from two monodentate carboxylate groups and by one O atom each from a methanol and a dimethylformamide (DMF) ligand. The single-crystal structure crystallizes in the triclinic space group P\\overline{1}. Moreover, the coordination polymer shows one-dimensional 2-connected {0} uninodal chain networks, and free DMF molecules are connected to the chains by O-H···O hydrogen bonds. The thermogravimetric and photoluminescent properties of the compound have also been investigated. PMID:26322606

  16. A novel technique for measurement of thermal rate constants and temperature dependences of dissociative recombination: CO2(+), CF3(+), N2O(+), C7H8(+), C7H7(+), C6H6(+), C6H5(+), C5H6(+), C4H4(+), and C3H3(+).

    PubMed

    Fournier, Joseph A; Shuman, Nicholas S; Melko, Joshua J; Ard, Shaun G; Viggiano, Albert A

    2013-04-21

    A novel technique using a flowing afterglow-Langmuir probe apparatus for measurement of temperature dependences of rate constants for dissociative recombination (DR) is presented. Low (~10(11) cm(-3)) concentrations of a neutral precursor are added to a noble gas∕electron afterglow plasma thermalized at 300-500 K. Charge exchange yields one or many cation species, each of which may undergo DR. Relative ion concentrations are monitored at a fixed reaction time while the initial plasma density is varied between 10(9) and 10(10) cm(-3). Modeling of the decrease in concentration of each cation relative to the non-recombining noble gas cation yields the rate constant for DR. The technique is applied to several species (O2(+), CO2(+), CF3(+), N2O(+)) with previously determined 300 K values, showing excellent agreement. The measurements of those species are extended to 500 K, with good agreement to literature values where they exist. Measurements are also made for a range of CnHm(+) (C7H7(+), C7H8(+), C5H6(+), C4H4(+), C6H5(+), C3H3(+), and C6H6(+)) derived from benzene and toluene neutral precursors. CnHm(+) DR rate constants vary from 8-12 × 10(-7) cm(3) s(-1) at 300 K with temperature dependences of approximately T(-0.7). Where prior measurements exist these results are in agreement, with the exception of C3H3(+) where the present results disagree with a previously reported flat temperature dependence. PMID:23614415

  17. Thermal expansion, thermal conductivity, and heat capacity measurements for boreholes UE25 NRG-4, UE25 NRG-5, USW NRG-6, and USW NRG-7/7A

    SciTech Connect

    Brodsky, N.S.; Riggins, M.; Connolly, J.; Ricci, P.

    1997-09-01

    Specimens were tested from four thermal-mechanical units, namely Tiva Canyon (TCw), Paintbrush Tuff (PTn), and two Topopah Spring units (TSw1 and TSw2), and from two lithologies, i.e., welded devitrified (TCw, TSw1, TSw2) and nonwelded vitric tuff (PTn). Thermal conductivities in W(mk){sup {minus}1} averaged over all boreholes, ranged (depending upon temperature and saturation state) from 1.2 to 1.9 for TCw, from 0.4 to 0.9 for PTn, from 1.0 to 1.7 for TSw1, and from 1.5 to 2.3 for TSw2. Mean coefficients of thermal expansion were highly temperature dependent and values, averaged over all boreholes, ranged (depending upon temperature and saturation state) from 6.6 {times} 10{sup {minus}6} to 49 {times} 10{sup {minus}6} C{sup {minus}1} for TCw, from the negative range to 16 {times} 10{sup {minus}6} {center_dot} {degree}C{sup {minus}1} for PTn, from 6.3 {times} 10{sup {minus}6} to 44 {times} 10{sup {minus}6} C{sup {minus}1} for TSw1, and from 6.7 {times} 10{sup {minus}6} to 37 {times} 10{sup {minus}6} {center_dot} {degree}C{sup {minus}1} for TSw2. Mean values of thermal capacitance in J/cm{sup 3}K (averaged overall specimens) ranged from 1.6 J to 2.1 for TSw1 and from 1.8 to 2.5 for TSw2. In general, the lithostratigraphic classifications of rock assigned by the USGS are consistent with the mineralogical data presented in this report.

  18. Synthesis of polysubstituted 4,5,6,7-tetrahydrofuro[2,3-c]pyridines by a novel multicomponent reaction.

    PubMed

    Fayol, Aude; Zhu, Jieping

    2004-01-01

    [reaction: see text] A novel three-component synthesis of tetrahydrofuro[2,3-c]pyridines from readily accessible starting materials is described. Simply heating a toluene solution of an aminopentynoate, an aldehyde, and an alpha-isocyanoacetamide in the presence of ammonium chloride provided the 4,5,6,7-tetrahydrofuro[2,3-c]pyridines in good to excellent yield. The fused ring system is produced in this one-pot process by the concomitant formation of five chemical bonds. PMID:14703364

  19. The effects of 7.5% NaCl/6% dextran 70 on coagulation and platelet aggregation in humans

    NASA Technical Reports Server (NTRS)

    Hess, J. R.; Dubick, M. A.; Summary, J. J.; Bangal, N. R.; Wade, C. E.

    1992-01-01

    The combination solution of 7.5% NaCl/6% dextran 70 (HSD) administered IV gives hemodynamic improvement in the treatment of hemorrhagic hypotension. Since earlier dextran solutions were reported to interfere with blood coagulation, the effects of HSD on the prothrombin time (PT), the activated partial thromboplastin time (APTT), platelet aggregation, and platelet concentration were studied. The HSD mixed with human plasma (1:5 and 1:10) slightly prolonged PT, but had no effect on the APTT, compared with saline controls. The HSD also decreased human platelet aggregation at the 1:5 dilution. In separate mixing studies, the hypertonic saline component of HSD was associated with the prolongation of PT and decreased platelet aggregation. The data from these studies indicate that at its proposed therapeutic dose, HSD is expected to have minimal effect on blood coagulation.

  20. Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase

    PubMed Central

    Lanyon-Hogg, Thomas; Masumoto, Naoko; Bodakh, George; Konitsiotis, Antonio D.; Thinon, Emmanuelle; Rodgers, Ursula R.; Owens, Raymond J.; Magee, Anthony I.; Tate, Edward W.

    2016-01-01

    In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article “Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase” (Lanyon-Hogg et al., 2015) [1]. 1H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors. PMID:27077078

  1. Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase.

    PubMed

    Lanyon-Hogg, Thomas; Masumoto, Naoko; Bodakh, George; Konitsiotis, Antonio D; Thinon, Emmanuelle; Rodgers, Ursula R; Owens, Raymond J; Magee, Anthony I; Tate, Edward W

    2016-06-01

    In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed "RU-SKI") class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article "Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase" (Lanyon-Hogg et al., 2015) [1]. (1)H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors. PMID:27077078

  2. Photophysical properties of ESIPT inspired fluorescent 2-(2-hydroxyphenyl)-6-methylimidazo[4,5-f]isoindole-5,7(1H,6H)-dione and its derivative: Experimental and DFT based approach

    NASA Astrophysics Data System (ADS)

    Deshmukh, Mininath S.; Sekar, Nagaiyan

    2015-01-01

    The excited-state intramolecular proton transfer chromophores 2-(2-hydroxyphenyl)-6-methylimidazo[4,5-f]isoindole-5,7(1H,6H)-dione and 2-(4-(diethylamino)-2-hydroxyphenyl)-6-methylimidazo[4,5-f]isoindole-5,7(1H,6H)-dione are synthesized from 4,5-diamino-N-methylphthalimide. The photophysical behavior of the synthesized chromophores was studied using UV-visible and fluorescence spectroscopy in the polar and non-polar solvents. The synthesized o-hydroxyphenyl benzimidazole derivatives are fluorescent and very sensitive to the solvent polarity. These dyes are thermally stable up to 317 °C. Density Functional Theory computations have been used to understand the structural, molecular, electronic and photophysical properties of the chromophores. The experimental absorption and emission wavelengths are in good agreement with the computed vertical excitation and theoretical emission obtained by Density Functional Theory and Time Dependant Density Functional Theory.

  3. Different requirements for proteolytic processing of bone morphogenetic protein 5/6/7/8 ligands in Drosophila melanogaster.

    PubMed

    Fritsch, Cornelia; Sawala, Annick; Harris, Robin; Maartens, Aidan; Sutcliffe, Catherine; Ashe, Hilary L; Ray, Robert P

    2012-02-17

    Bone morphogenetic proteins (BMPs) are synthesized as proproteins that undergo proteolytic processing by furin/subtilisin proprotein convertases to release the active ligand. Here we study processing of BMP5/6/7/8 proteins, including the Drosophila orthologs Glass Bottom Boat (Gbb) and Screw (Scw) and human BMP7. Gbb and Scw have three functional furin/subtilisin proprotein convertase cleavage sites; two between the prodomain and ligand domain, which we call the Main and Shadow sites, and one within the prodomain, which we call the Pro site. In Gbb each site can be cleaved independently, although efficient cleavage at the Shadow site requires cleavage at the Main site, and remarkably, none of the sites is essential for Gbb function. Rather, Gbb must be processed at either the Pro or Main site to produce a functional ligand. Like Gbb, the Pro and Main sites in Scw can be cleaved independently, but cleavage at the Shadow site is dependent on cleavage at the Main site. However, both Pro and Main sites are essential for Scw function. Thus, Gbb and Scw have different processing requirements. The BMP7 ligand rescues gbb mutants in Drosophila, but full-length BMP7 cannot, showing that functional differences in the prodomain limit the BMP7 activity in flies. Furthermore, unlike Gbb, cleavage-resistant BMP7, although non-functional in rescue assays, activates the downstream signaling cascade and thus retains some functionality. Our data show that cleavage requirements evolve rapidly, supporting the notion that changes in post-translational processing are used to create functional diversity between BMPs within and between species.

  4. Protective effects of (6R)-5,6,7,8-tetrahydro-l-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva

    PubMed Central

    Tanaka, Yusaku; Toyama, Toshizo; Wada-Takahashi, Satoko; Sasaki, Haruka; Miyamoto, Chihiro; Maehata, Yojiro; Yoshino, Fumihiko; Yoshida, Ayaka; Takahashi, Shun-suke; Watanabe, Kiyoko; Lee, Masaichi-Chang-il; Todoki, Kazuo; Hamada, Nobushiro

    2016-01-01

    We herein investigated the regulatory mechanism in the circulation responsible for rat gingival reactive hyperemia (RH) associated with ischemia/reperfusion (I/R). RH was analyzed using a laser Doppler flowmeter. RH and I/R were elicited by gingival compression and release with a laser Doppler probe. RH increased in a time-dependent manner when the duration of compression was between 30 s and 20 min. This increase was significantly suppressed by Nω-nitro-l-arginine-methyl-ester (l-NAME), 7-nitroindazole (7-NI), and 2,4-diamino-6-hydroxypyrimidine (DAHP). However, RH was markedly inhibited following 60 min of compression. This inhibition was significantly decreased by treatments with superoxide dismutase (SOD), (6R)-5,6,7,8-tetrahydro-l-biopterin (BH4), and sepiapterin. The luminescent intensity of superoxide anion (O2•−)-induced 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo-[1,2-a] pyrazine-3-one (MCLA) was markedly decreased by SOD and BH4, but only slightly by sepiapterin. BH4 significantly decreased O2•− scavenging activity in a time-dependent manner. These results suggested that nitric oxide (NO) secreted by the nitrergic nerve played a role in regulating local circulation in rat gingiva. This NO-related regulation of local circulation was temporarily inhibited in the gingiva by the I/R treatment. The decrease observed in the production of NO, which was caused by suppression of NO synthase (NOS) activity subsequent to depletion of the NOS co-factor BH4 by O2•−, played a partial role in this inhibition. PMID:26798200

  5. Pyrolysis of Tropyl Radical (C7H7) and Benzyl Radical (C6H5CH2) in a Heated Micro-Reactor

    NASA Astrophysics Data System (ADS)

    Buckingham, Grant; Ellison, Barney; Porterfield, Jessica P.; Daily, John W.; Ahmed, Musahid; Robichaud, David; Nimlos, Mark R.

    2016-06-01

    Benzyl radical (C6H5CH2) is a crucial intermediate in the combustion and pyrolysis of substituted aromatic species that are common both in modern gasoline and potential future biofuels. The decomposition of benzyl radical is complicated and has been shown by isotopic labeling to require interesting isomerizations pathways. To better understand these pathways, a set of C7H7 radicals has been studied in a heated micro-reactor. Through multiple experiments, it has be shown that benzyl radical and cycloheptatrienyl (tropyl) radical (c-C7H7) do not interconvert, even at temperatures where both have completely thermally decomposed. To confirm this, tropyl radical has been studied directly and its pyrolysis is quite simple, only cyclopentadienyl radical (c-C5H5) and acetylene (HCCH) are formed. Cyclopentadienyl radical then decomposes to acetylene and propargyl radical (HCCCH2). These products have all been identified through use of tunable synchrotron radiation by confirming their respective photoionization spectra. Matrix isolation infrared (IR) spectroscopy has also been used to identity these products. A previously unanswered question in benzyl radical decomposition has been addressed by studying the pyrolysis of 2,5-norbornadiene, which indicates benzyl radical may decompose through a norbornadiene-like bicyclic radical intermediate. This pathways successfully predicts the correct isotopically labeled products observed previously during 13C labeled benzyl pyrolysis.

  6. Synthesis and anticancer activities of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline derivatives.

    PubMed

    Zhang, Ying; Huang, Yin-Jiu; Xiang, Hong-Mei; Wang, Pei-Yi; Hu, De-Yu; Xue, Wei; Song, Bao-An; Yang, Song

    2014-05-01

    A series of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline was prepared by conventional heating methods. Among these compounds, the crystal structure of compound 10o (CCDC: 916922) was determined by X-ray crystallography. Bioassay results showed that most target compounds had certain inhibition activities against proliferation of tumor cells, and some compounds even had good broad-spectrum inhibition activities. The ethoxyl series of compounds possessed higher inhibition activities against tumor cells than the methoxyl series of compounds. Bioactivity tests showed that the IC50 values of compound 10s against PC3, MGC803, A375, and A549 cells were 1.8, 2.8, 1.3, and 2.9 μΜ, respectively, which were much higher than those of commercial gefitinib (7.2, 7.6, 7.2, and 9.8 μM, respectively). Conversely, the IC50 values of compound 10s were very low against NH3T3, indicating only weak effect on normal cells as also proven by lactate dehydrogenase and acridine orange/ethidium bromide staining. Analyses of cell configuration and cell cycle revealed that compound 10s possibly caused cells to remain at G0/G1 phase by inhibiting cell proliferation for 24 h. Compound 10s also inhibited the phosphorylation of ERK1/2 and P38 with obvious concentration dependence. Thus, these compounds can inhibit the proliferation of A549 cells through the interruption of ERK1/2 and P38signaling pathways.

  7. Synthesis and anticancer activities of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline derivatives.

    PubMed

    Zhang, Ying; Huang, Yin-Jiu; Xiang, Hong-Mei; Wang, Pei-Yi; Hu, De-Yu; Xue, Wei; Song, Bao-An; Yang, Song

    2014-05-01

    A series of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline was prepared by conventional heating methods. Among these compounds, the crystal structure of compound 10o (CCDC: 916922) was determined by X-ray crystallography. Bioassay results showed that most target compounds had certain inhibition activities against proliferation of tumor cells, and some compounds even had good broad-spectrum inhibition activities. The ethoxyl series of compounds possessed higher inhibition activities against tumor cells than the methoxyl series of compounds. Bioactivity tests showed that the IC50 values of compound 10s against PC3, MGC803, A375, and A549 cells were 1.8, 2.8, 1.3, and 2.9 μΜ, respectively, which were much higher than those of commercial gefitinib (7.2, 7.6, 7.2, and 9.8 μM, respectively). Conversely, the IC50 values of compound 10s were very low against NH3T3, indicating only weak effect on normal cells as also proven by lactate dehydrogenase and acridine orange/ethidium bromide staining. Analyses of cell configuration and cell cycle revealed that compound 10s possibly caused cells to remain at G0/G1 phase by inhibiting cell proliferation for 24 h. Compound 10s also inhibited the phosphorylation of ERK1/2 and P38 with obvious concentration dependence. Thus, these compounds can inhibit the proliferation of A549 cells through the interruption of ERK1/2 and P38signaling pathways. PMID:24675177

  8. 40 CFR 721.5262 - 2,7-Naphthalenedisulfonic acid, 5-[[4-chloro-6-[substituted] amino]-1,3,5-triazin-2-yl]amino]-4...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt... identified generically as 2,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 2,7-Naphthalenedisulfonic acid,...

  9. 40 CFR 721.5262 - 2,7-Naphthalenedisulfonic acid, 5-[[4-chloro-6-[substituted] amino]-1,3,5-triazin-2-yl]amino]-4...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt... identified generically as 2,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3... 40 Protection of Environment 32 2012-07-01 2012-07-01 false 2,7-Naphthalenedisulfonic acid,...

  10. 40 CFR 721.5262 - 2,7-Naphthalenedisulfonic acid, 5-[[4-chloro-6-[substituted] amino]-1,3,5-triazin-2-yl]amino]-4...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt... identified generically as 2,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3... 40 Protection of Environment 31 2011-07-01 2011-07-01 false 2,7-Naphthalenedisulfonic acid,...

  11. 40 CFR 721.5262 - 2,7-Naphthalenedisulfonic acid, 5-[[4-chloro-6-[substituted] amino]-1,3,5-triazin-2-yl]amino]-4...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt... identified generically as 2,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3... 40 Protection of Environment 32 2013-07-01 2013-07-01 false 2,7-Naphthalenedisulfonic acid,...

  12. Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824

    PubMed Central

    Li, Xiaojin; Manjunatha, Ujjini H.; Goodwin, Michael B.; Knox, John E.; Lipinski, Christopher A.; Keller, Thomas H.; Barry, Clifton E.; Dowd, Cynthia S.

    2008-01-01

    Nitroimidazoles such as PA-824 and OPC-67683 are currently in clinical development as members of a promising new class of therapeutics for tuberculosis. While the antitubercular activity of these compounds is high, they both suffer from poor water solubility thus complicating development. We determined the single-crystal X-ray structure of PA-824 and found a close packing of the nitroimidazoles facilitated by a pseudoaxial conformation of the p-trifluoromethoxybenzyl ether. To attempt to disrupt this tight packing by destabilizing the axial preference of this side chain, we prepared the two diastereomers of the 7-methyl-nitroimidazo-oxazine. Determination of the crystal structure of the 7-(S)-methyl derivative (5, cis) revealed that the benzylic side chain remained pseudoaxial while the 7-(R)-methyl derivative (6, trans) adopted the desired pseudoequatorial conformation. Both derivatives displayed similar activities against Mycobacterium tuberculosis, but neither showed improved aqueous solubility, suggesting that inherent lattice stability is not likely to be a major factor in limiting solubility. Conformational analysis revealed that all three compounds have similar energetically accessible conformations in solution. Additionally, these results suggest that the nitroreductase that initially recognizes PA-824 is somewhat insensitive to substitutions at the 7-position. PMID:18358721

  13. Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.

    PubMed

    Liao, Shixian; Deng, Hui; Huang, Shengbin; Yang, Jingyuan; Wang, Siqian; Yin, Baodi; Zheng, Tieli; Zhang, Dafeng; Liu, Jinsong; Gao, Guohui; Ma, Jianfeng; Deng, Zhennan

    2015-04-01

    A series of 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease (AD). The results showed that the target compounds exhibited good acetylcholinesterase (AChE) inhibitory potencies, high selectivity toward AChE over butyrylcholinesterase (BuChE), potential antioxidant activities and significant inhibitory potencies of self-induced beta-amyloid peptide (Aβ) aggregation. In particular, compound 14c had the strongest AChE inhibitory activity with IC50 value of 12.8 nM, potent inhibition of self-induced Aβ1-42 aggregation with inhibition ratio of 33.8% at 25 μM. Moreover, compound 14c acted as an antioxidant, as well as a neuroprotectant. Furthermore, 14c could cross the blood-brain barrier (BBB) in vitro. The results showed that compound 14c might be a potential multifunctional candidate for the treatment of AD. PMID:25724825

  14. Results of a statistical approach to rainfall estimation using Nimbus 5 6.7 micrometers and 11.5 micrometers THIR data

    NASA Technical Reports Server (NTRS)

    Ormsby, J. P.

    1979-01-01

    Nimbus 5 6.7 mm and 11.5 mm temperature humidity infrared radiometer (THIR) data were used in a simple multiple regression scheme to test the feasibility of using these data to estimate hourly rainfall. Throughout the test area (85 W to 105 W and 45 N to 30 N) subareas (8 deg x 6 deg) were chosen from which point to point and areal statistics were obtained. Four subsets of data were used. The first consisted of only those surface stations indicating precipitation whose latitude and longitude coincided with the THIR grid points. A second used surface stations 0.1 degree from the THIR grid points. The third was a combination of subsets one and two. A reciprocal distance weighting scheme was used to derive precipitation values in data sparse areas. A fourth subset was made using these data combined with the data from subsets one and two. Point estimates resulted in negative correlations between estimated and grid derived "surface" precipitation. One degree areal estimates showed a slight improvement with a correlation coefficient of approximately 0.11. Single regression areal estimates resulted in correlations of approximately 0.11 and 0.20 for the 6.7 mm and 11.5 mm data respectively. These poor results were attributed to problems which are inherent in the satellite data (location errors, short temporal span of data, wavelength of sensors, etc.) and the lack of sufficient surface data to better verify the satellite estimate.

  15. SAMS Acceleration Measurements on Mir from May 1997 to June 1998 (NASA Increments 5, 6, and 7)

    NASA Technical Reports Server (NTRS)

    DeLombard, Richard

    1999-01-01

    During NASA Increments 5, 6, and 7 (May 1997 to June 1998), about eight gigabytes of acceleration data were collected by the Space Acceleration Measurement System (SAMS) onboard the Russian Space Station Mir. The data were recorded on twenty-seven optical disks which were returned to Earth on Orbiter missions STS-86, STS-89, and STS-91. During these increments, SAMS data were collected in the Priroda module to support various microgravity experiments. This report points out some of the salient features of the microgravity acceleration environment to which the experiments were exposed. This report presents an overview of the SAMS acceleration measurements recorded by 10 Hz and 100 Hz sensor heads. The analyses included herein complement those presented in previous Mir increment summary reports prepared by the Principal Investigator Microgravity Services project.

  16. Halogen Bonding and Chalcogen Bonding in 4,7-Dibromo-5,6-dinitro-2,1,3-benzothiadiazole.

    PubMed

    Pavan, Mysore S; Jana, Ajay Kumar; Natarajan, S; Guru Row, Tayur N

    2015-08-27

    An organic solid, 4,7-dibromo-5,6-dinitro-2,1,3-benzothiadiazole, has been designed to serve as an illustrative example to quantitatively evaluate the relative merits of halogen and chalcogen bonding in terms of charge density features. The compound displays two polymorphic modifications, one crystallizing in a non-centrosymmetric space group (Z' = 1) and the other in a centrosymmetric space group with two molecules in the asymmetric unit (Z' = 2). Topological analysis based on QTAIM clearly brings out the dominance of the chalcogen bond over the halogen bond along with an indication that halogen bonds are more directional compared to chalcogen bonds. The cohesive energies calculated with the absence of both strong and weak hydrogen bonds as well as stacking interaction are indicative of the stabilities associated with the polymorphic forms.

  17. Molecular and crystal structures of some novel derivatives of 3-aryl-7-arylidene-3,3a,4,5,6,7-hexahydroindazoles

    SciTech Connect

    Abakumov, V. V.; Shishkina, S. V.; Zubatyuk, R. I.; Gella, I. M.; Pivnenko, N. S.; Kutulya, L. A. Shishkin, O. V.

    2007-03-15

    The stereochemical aspects of the interaction of 2,6-bis(arylidene)-cyclohexanone and 2,6-bis(arylidene)-3-methylcyclohexanone with arylhydrazine (aryl is phenyl or 4-nitrophenyl) and methylhydrazine are investigated using X-ray diffraction analysis. The molecular structure of the 3-aryl-7-arylidene-3,3a,4,5,6,7-hexahydroindazoles synthesized is determined by X-ray diffraction analysis for the first time. It is established that the stereochemistry of the products of the interaction between the cyclohexanone derivatives and arylhydrazines depends on the electronic nature of the substituent in the aryl group. Two regioisomeric products with different positions of the methyl group in the cyclohexane ring with respect to the arylidene fragment are synthesized by the reaction of 2,6-bis(4-methoxybenzylidene)-3-methylcyclohexanone with methylhydrazine. The influence of the substituents at the nitrogen atom of the pyrazoline ring on the intramolecular electronic interactions and the geometry of the heterocycle in the compounds under investigation is discussed.

  18. MELCOR 1.8.2 assessment: Aerosol experiments ABCOVE AB5, AB6, AB7, and LACE LA2

    SciTech Connect

    Souto, F.J.; Haskin, F.E.; Kmetyk, L.N.

    1994-10-01

    The MELCOR computer code has been used to model four of the large-scale aerosol behavior experiments conducted in the Containment System Test Facility (CSTF) vessel. Tests AB5, AB6 and AB7 of the ABCOVE program simulate the dry aerosol conditions during a hypothetical severe accident in an LMFBR. Test LA2 of the LACE program simulates aerosol behavior in a condensing steam environment during a postulated severe accident in an LWR with failure to isolate the containment. The comparison of code results to experimental data show that MELCOR is able to correctly predict most of the thermal-hydraulic results in the four tests. MELCOR predicts reasonably well the dry aerosol behavior of the ABCOVE tests, but significant disagreements are found in the aerosol behavior modelling for the LA2 experiment. These results tend to support some of the concerns about the MELCOR modelling of steam condensation onto aerosols expressed in previous works. During these analyses, a limitation in the MELCOR input was detected for the specification of the aerosol parameters for more than one component. A Latin Hypercube Sampling (LHS) sensitivity study of the aerosol dynamic constants is presented for test AB6. The study shows the importance of the aerosol shape factors in the aerosol deposition behavior, and reveals that MELCOR input/output processing is highly labor intensive for uncertainty and sensitivity analyses based on LHS.

  19. Synthesis and characterization of p-type conductivity dopant 2-(3-(adamantan-1-yl)propyl)-3,5,6-trifluoro-7,7,8,8-tetracyanoquinodimethane

    SciTech Connect

    Rainbolt, James E.; Koech, Phillip K.; Polikarpov, Evgueni; Swensen, James S.; Cosimbescu, Lelia; Von Ruden, Amber L.; Wang, Liang; Sapochak, Linda S.; Padmaperuma, Asanga B.; Gaspar, Daniel J.

    2013-01-22

    We report the synthesis and characterization of 2-(3-(adamantan-1-yl)propyl)-3,5,6-trifluoro-7,7,8,8-tetracyanoquinodimethane (F3TCNQ-Ad1), a substituted analog of 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ), designed for p-type conductivity doping. The dopant is designed as a model for substituted alternatives to F4TCNQ that maintain similar electronic properties with the goal of engineering dopants with superior fabrication characteristics over F4TCNQ. We describe the design strategy for F3TCNQ-Ad1 based on molecular modeling predictions that substitution of a single fluorine atom of F4TCNQ has little effect on the electronic properties of the molecule. Photophysical and electrochemical characterization reveal that the adamantyl substituent in F3TCNQ-Ad1 does not significantly alter the electronic properties of the substituted dopant relative to F4TCNQ. Unfortunately, F3TCNQ-Ad1 degrades under standard sublimation conditions, preventing sublimation deposition processing. Instead, hole-only devices were made via solution-processing of the p-doped films with the structure glass/ITO/2.3 x103Å PVK:(MTDATA:dopant)/2.0x102Å Au/1.0x103Å Al, where dopant is either F4TCNQ or F3TCNQ-Ad1. We demonstrate that F3TCNQ-Ad1 increased the conductivity of the films by at least 1,000 times compared to an undoped device.

  20. Development of a high-resolution record of Great Basin climate change during MIS 5, 6, and 7

    NASA Astrophysics Data System (ADS)

    Cross, M.; McGee, D.; Broecker, W. S.; Quade, J.; Cheng, H.; Edwards, R.

    2013-12-01

    As evinced by the cycles of the large paleolakes Lahontan and Bonneville, the currently semi-arid to arid Great Basin region of the United States has experienced significant changes in climate and water balance in the past. Although there has been substantial research concerning these changes for times around and since the last glacial maximum, relatively little is known about the region's previous climate and water balance history. There is a clear need for a long-term record for earlier glacial and interglacial periods. Here, we present some of our initial results from Lehman Cave (39.01°N, 114.22°W), a well-decorated, active cave located on the edge of the Bonneville Basin in the Great Basin National Park, for times correlating with large portions of Marine Oxygen Isotope Stages (MIS) 5, 6, and 7. We initially surveyed a suite of speleothems to obtain times and durations of growth phases to aid in choosing samples appropriate for more extensive analysis. Approximately eighty 2 to 10 mg samples with a mean 238U of 400 ppb, representing most of the major growth phases of this suite of 20 speleothems, were analyzed for preliminary uranium-thorium dates. A subset of eight of these stalagmites grew collectively over large portions of MIS 5 and 6 (an interval that includes the Little Valley lake cycle of the Bonneville Basin) as well as a substantial portion of MIS 7. This record includes several significant periods of contemporaneous growth, including: 81.5 to 103 ka, which corresponds to the interval between Dansgaard-Oeschger events 21 and 23; 204 to 207 ka; and 118 to 132 ka, an interval including the beginning of the last interglacial period and the end of Termination II and Heinrich Stadial 11. We have yet to identify growth phases between 103 to 118 ka, 134 to 137 ka, and 164 to 169 ka. Initial stable isotope results indicate a shift of approximately +3‰ δ18O and +5‰ δ13C around 131 × 2.5 ka, which agrees within error with the findings of Shakun et al

  1. Effects of 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane doping on diketopyrrolopyrrole-based, low crystalline, high mobility polymeric semiconductor

    SciTech Connect

    Yoon, Seongwon; Cho, Jangwhan; Chung, Dae Sung; Lee, Han-Koo; Park, Sungmin; Son, Hae Jung

    2015-09-28

    The effects of 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ) doping on diketopyrrolo-pyrrole-based polymeric semiconductors in terms of charge transport behavior and structural ordering are systematically investigated. Although the energy level offset between the polymeric semiconductor and the F4TCNQ acceptor was not particularly large, ultraviolet photoelectron spectroscopy analyses revealed that a low doping ratio of 1 wt. % is sufficient to tune the energy distance between the Fermi level and the HOMO level, reaching saturation at roughly 5 wt. %, which is further confirmed by the depletion mode measurements of field effect transistors (FETs). Structural analyses using grazing-incidence X-ray diffraction (GIXD) show that the overall degree of edge-on orientation is disturbed by the addition of dopants, with significant influence appearing at high doping ratios (>3 wt. %). The calculated charge carrier mobility from accumulation mode measurements of FETs showed a maximum value of 2 cm{sup 2}/V·s at the optimized doping ratio of 1%, enabled by additional holes in the channel region, which results in a roughly 40% increase relative to the undoped device. Further increases in the doping ratio, however, resulted in worse FET performance, which can be attributed to structural deformation. This result suggests that the electrochemical doping method can be also applied to donor-acceptor copolymers to further enhance their charge transport characteristics, once the optimized doping condition has been established.

  2. Single-Step Synthesis of 5,6,7,8-Tetrahydroindolizines via Annulation of 2-Formylpiperidine and 1,3-Dicarbonyl Compounds.

    PubMed

    Capomolla, Simona S; Lim, Ngiap-Kie; Zhang, Haiming

    2015-07-17

    An expedient single-step synthesis of 5,6,7,8-tetrahydroindolizines has been achieved via the annulation of commercially available 2-formylpiperidine hydrochloride and 1,3-dicarbonyl compounds in THF in the presence of pyrrolidine and 4 Å molecular sieves. A variety of β-ketoesters, ketones, and amides participated in this annulation chemistry, affording the desired 5,6,7,8-tetrahydroindolizines in moderate to good yields.

  3. In Situ TEM Observations of Cu6Sn5 Polymorphic Transformations in Reaction Layers Between Sn-0.7Cu Solders and Cu Substrates

    NASA Astrophysics Data System (ADS)

    Nogita, K.; Mohd Salleh, M. A. A.; Tanaka, E.; Zeng, G.; McDonald, S. D.; Matsumura, S.

    2016-07-01

    Direct evidence of the relationship between the polymorphic phase transformation from monoclinic Cu6Sn5 to hexagonal Cu6Sn5 and stress accumulation/release in Cu6Sn5, formed at the interface between Sn-0.7Cu lead-free solder and their Cu substrates, has been obtained. To explore this challenging phenomenon, we developed an in situ heating/isothermal observation technique in ultrahigh-voltage transmission electron microscopy that enables the observation of thick samples (around 0.5 μm) for solder joints, including Cu/Cu3Sn/Cu6Sn5/Sn-0.7Cu solder interfaces prepared by a focused ion beam milling technique. The results show evidence of stress creation and release events by imaging bend contours that may arise due to the polymorphic transformations of the Cu6Sn5 phase and the associated volumetric change.

  4. X-ray studies of 2-amino-4-(3-nitrophenyl)-5-oxo-4,5-dihydropyrano[3,2- c] chromene-3-carbonitrile and 2-amino-7,7-dimethyl-4-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4 H-chromene-3-carbonitrile

    NASA Astrophysics Data System (ADS)

    Sharma, S.; Banerjee, B.; Brahmachari, G.; Kant, R.; Gupta, V. K.

    2015-12-01

    Two carbonitrile compounds, 2-amino-4-(3-nitrophenyl)-5-oxo-4,5-dihydropyrano[3,2- c] chromene-3-carbonitrile ( I) and 2-amino-7,7-dimethyl-4-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4 H-chromene-3-carbonitrile ( II), were synthesized, and their crystal structures were determined by X-ray diffraction technique. The crystals are triclinic, a = 7.7970(12), 8.2171(7), b = 9.0390(10), 9.2238(7), c = 15.148(2), 14.5585(11) Å, α = 81.439(10)°, 74.895(6)°, β = 75.194(12)°, 87.392(6)°, γ = 76.151(11)°, 78.552(7)°, for I and II, respectively, Z = 2, sp. gr. P overline 1. The pyran ring in both the compounds deviates significantly from planarity and adopts boat conformation. The crystal structure is stabilized by N-H···O and N-H···N hydrogen bonds.

  5. 5-Demethylnobiletin and 5-Acetoxy-6,7,8,3',4'-pentamethoxyflavone Suppress Lipid Accumulation by Activating the LKB1-AMPK Pathway in 3T3-L1 Preadipocytes and High Fat Diet-Fed C57BL/6 Mice.

    PubMed

    Tung, Yen-Chen; Li, Shiming; Huang, Qingrong; Hung, Wei-Lun; Ho, Chi-Tang; Wei, Guor-Jien; Pan, Min-Hsiung

    2016-04-27

    Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones (HPMFs), such as nobiletin (Nob) and 5-demethylnobiletin (5-OH-Nob), are unique flavonoids that are found exclusively in citrus peels. Nobiletin has been shown to suppress adipogenesis in vitro, but the antiadipogenic activity of 5-OH-Nob has not been investigated. Both nobiletin and 5-OH-Nob have poor aqueous solubility and low oral bioavailability. We employed chemical modification to produce the acetyl derivative of 5-OH-Nob, that is, 5-acetyloxy-6,7,8,3',4'-pentamethoxyflavone (5-Ac-Nob), to improve its bioavailability and bioactive efficiency. We found that 5-Ac-Nob reduced triacylglycerol (TG) content to a greater extent than 5-OH-Nob in 3T3-L1 preadipocytes. Orally administered 5-Ac-Nob resulted in a significant reduction in body weight, intra-abdominal fat, plasma and liver TG levels, and plasma cholesterol level in high fat diet-induced obese male C57BL/6J mice. The 5-Ac-Nob treatment decreased lipid accumulation by triggering the adenosine 5'-monophosphate-activated protein kinase (AMPK) pathway to alter transcriptional factors or lipogenesis-related enzymes in vivo and in vitro. PMID:27041493

  6. 40 CFR 721.5262 - 2,7-Naphthalenedisulfonic acid, 5-[[4-chloro-6-[substituted] amino]-1,3,5-triazin-2-yl]amino]-4...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...,7-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt...-Naphthalenedisulfonic acid, 5- amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, trisodium salt (PMN P-00-0803) is...-naphthalenedisulfonic acid, 5- ethyl]amino]-1,3,5-triazin-2-yl]amino]-4-hydroxy-3- -, sodium salt (1:3) (PMN......

  7. Thermodynamic data of the high-pressure phase Mg5Al5Si6O21(OH)7 (Mg-sursassite)

    NASA Astrophysics Data System (ADS)

    Grevel, K.-D.; Navrotsky, A.; Kahl, W. A.; Fasshauer, D. W.; Majzlan, J.

    Calorimetric and P-V-T data for the high-pressure phase Mg5Al5Si6O21(OH)7 (Mg-sursassite) have been obtained. The enthalpy of drop solution of three different samples was measured by high-temperature oxide melt calorimetry in two laboratories (UC Davis, California, and Ruhr University Bochum, Germany) using lead borate (2PbO.B2O3) at T=700∘C as solvent. The resulting values were used to calculate the enthalpy of formation from different thermodynamic datasets; they range from -221.1 to -259.4kJmol-1 (formation from the oxides) respectively -13892.2 to -13927.9kJmol-1 (formation from the elements). The heat capacity of Mg5Al5Si6O21(OH)7 has been measured from T=50 ∘C to T=500 ∘C by differential scanning calorimetry in step-scanning mode. A Berman and Brown (1985)-type four-term equation represents the heat capacity over the entire temperature range to within the experimental uncertainty: CP (Mg-sursassite) =(1571.104 -10560.89×T-0.5-26217890.0 ×T-2+1798861000.0×T-3) J K-1 mol-1 (T in K). The PVT behaviour of Mg-sursassite has been determined under high pressures and high temperatures up to 8GPa and 800∘C using a MAX 80 cubic anvil high-pressure apparatus. The samples were mixed with Vaseline to ensure hydrostatic pressure-transmitting conditions, NaCl served as an internal standard for pressure calibration. By fitting a Birch-Murnaghan EOS to the data, the bulk modulus was determined as 116.0+/-1.3GPa, (K'=4), VT,0=446.49 3 exp[∫(0.33+/-0.05) × 10-4 + (0.65+/-0.85)×10-8T dT], (KT/T)P=-0.011+/- 0.004GPaK-1. The thermodynamic data obtained for Mg-sursassite are consistent with phase equilibrium data reported recently (Fockenberg 1998); the best agreement was obtained with ΔfH0298 (Mg-sursassite)= -13901.33kJmol-1, and S0298 (Mg-sursassite)= 614.61JK-1mol-1.

  8. Co-seismic deformation of the August 27, 2012 Mw 7.3 El Salvador and September 5, 2012 Mw 7.6 Costa Rica earthquakes

    NASA Astrophysics Data System (ADS)

    Geirsson, H.; La Femina, P. C.; DeMets, C.; Mattioli, G. S.; Hernández, D.

    2013-05-01

    We investigate the co-seismic deformation of two significant earthquakes that occurred along the Middle America trench in 2012. The August 27 Mw 7.3 El Salvador and September 5 Mw 7.6 Nicoya Peninsula, Costa Rica earthquakes, were examined using a combination of episodic and continuous Global Positioning System (GPS) data. USGS finite fault models based on seismic data predict fundamentally different characteristics for the two ruptures. The El Salvador event occurred in a historical seismic gap and on the shallow segment of the Middle America Trench main thrust, rupturing a large area, but with a low magnitude of slip. A small tsunami was observed along the coast in Nicaragua and El Salvador, additionally indicating near-trench rupture. Conversely, the Nicoya, Costa Rica earthquake was predicted to have an order of magnitude higher slip on a spatially smaller patch deeper on the main thrust. We present results from episodic and continuous geodetic GPS measurements made in conjunction with the two earthquakes, including data from newly installed COCONet (Continuously Operating Caribbean GPS Observational Network) sites. Episodic GPS measurements made in El Salvador, Honduras, and Nicaragua following the earthquakes, allow us to estimate the co-seismic deformation field from both earthquakes. Because of the small magnitude of the El Salvador earthquake and its shallow rupture the observed co-seismic deformation is small (<2 cm). Conversely, the Costa Rica earthquake occurred directly beneath a seismic and geodetic network specifically designed to capture such events. The observed displacements exceeded 0.5 m and there is a significant post-seismic transient following the earthquake. We use our estimated co-seismic offsets for both earthquakes to model the magnitude and spatial variability of slip for these two events.

  9. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  10. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  11. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  12. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  13. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  14. Occurrence of Hexacosapolyenoic Acids 26:7(n-3), 26:6(n-3), 26:6(n-6) and 26:5(n-3) in Deep-Sea Brittle Stars from Near the Kuril Islands.

    PubMed

    Svetashev, Vasily; Kharlamenko, Vladimir

    2015-07-01

    Significant amounts of polyunsaturated fatty acids (PUFA) with a chain length of 26 carbon atoms were detected in lipids of five deep water species of Ophiuroidea besides common fatty acids with chain lengths between 14 and 24. By means of hydrogenation, GC-MS of the methyl esters, and 4,4-dimethyloxazoline (DMOX) derivatives of these C26 acids were characterized as 5,8,11,14,17,20,23-hexacosaheptaenoic [26:7(n-3)]; 8,11,14,17,20,23-hexacosahexaenoic [26:6(n-3)]; 5,8,11,14,17,20- hexacosahexaenoic [26:6(n-6)]; and 11,14,17,20,23-hexacosapentaenoic [26:5(n-3)]. Concentrations of these acids varied from 0.3 to 4.5 mol% of the total FA. In all the samples investigated, the main component of C26PUFA was hexacosaheptaenoic acid 26:7(n-3). These C26PUFA are localized mainly in polar lipids. The presence of the possible biosynthesis precursors suggests that the C26PUFA are produced by the brittle stars, and are not accumulated from food sources. This finding can also explain the presence of small amounts of the 26:7(n-3) acid detected earlier in flesh lipids of the roughscale sole Clidoderma asperrimum, which feeds on deep water brittle stars. We suggest a possible scheme of the biosynthesis of C26 PUFA.

  15. PROMIS series. Volume 7: GOES 5 and GOES 6 geosynchronous magnetic field data for March - June 1986

    NASA Technical Reports Server (NTRS)

    Fairfield, D. H.; Takahashi, K.

    1989-01-01

    This is the seventh in a series of volumes pertaining to the Polar Region Outer Magnetosphere International Study (PROMIS). This volume contains 24 hour plots of approximately 1-minute average magnetic fields from the GOES 5 and GOES 6 spacecraft for the period March 10 through June 16, 1986. Data are displayed in a VDH coordinate system based on a centered dipole with northern hemisphere geographic coordinates of the pole at 78.80 deg latitude and 289.24 deg longitude.

  16. DFT studies on a high-energy density cage compound 1, 3, 5, 7, 9, 11-hexo(N(CH3)NO2)-2, 4, 6, 8, 10, 12-hexaazatetracyclo[5, 5, 0, 0, 0] dodecane

    NASA Astrophysics Data System (ADS)

    Li, Xiao-Hong; Yong, Yong-Liang; Zhang, Xian-Zhou

    2014-04-01

    The infrared and Raman spectra, heat of formation (HOF) and thermodynamic properties were investigated by B3LYP/6-31G** method for a new designed polynitro cage compound 1,3,5,7,9,11-hexo(N(CH3)NO2)-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0,0]dodecane. The detonation velocity (D) and pressure (P) were predicted by the Kamlet-Jacobs equations based on the theoretical density and condensed HOF. The bond dissociation energies and bond orders for the weakest bonds were analysed to investigate the thermal stability of the title compound. The computational result shows that the detonation velocity and pressure of the title compound are superior to those of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), but inferior to those of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX) and hexanitrohexaazaisowurtzitane (HNIW). And the analysis of thermal stability shows that the first step of pyrolysis is the rupture of the N7-NO2 bond. The crystal structure obtained by molecular mechanics belongs to the P21 space group, with the lattice parameters Z = 2, a = 11.8246 Å, b = 10.4632 Å, c = 15.9713 Å, ρ = 1.98 g cm-3.

  17. Photoabsorption of the ground state of Ne and of Ne-like Na+, Mg2+, Al3+, Si4+, P5+, S6+, and Cl7+ ions

    NASA Astrophysics Data System (ADS)

    Sakho, I.

    2016-03-01

    Photoabsorption of the 1s2 2s2 2p6 (1S0) ground state of Ne-like ions is presented in this paper. Resonance energies and width of the 2 s 2p6 n p1P1 series of Ne and Ne-like Na+, Mg2+, Al3+, Si4+, P5+, S6+, and Cl7+ ions are reported. Wavelengths of the 2s2 2p6 (1S0) → 2s2 2p5(2P 3 / 2 , 1 / 2) n d transitions in neon-like Na+ ion and of the 2s2 2p6(1S0) → 2 s 2p6 n p1P1 transitions in Ne and in Ne-like Na+, Mg2+, Al3+, Si4+, P5+, S6+, and Cl7+ ions are tabulated. Analysis of the resonances investigated is done in the framework of the LS, jj and JK coupling schemes. All the calculations are made using the Screening constant by unit nuclear charge (SCUNC) formalism. Very good agreement is found between the SCUNC results and various experimental and theoretical literature values and new data for the Ne-like Si4+, P5+, S6+, and Cl7+ ions are listed.

  18. Crystal structures of the two epimers from the unusual thermal C6-epimerization of 5-oxo-1,2,3,5,5a,6,7,9b-octa­hydro-7,9a-ep­oxy­pyrrolo­[2,1-a]iso­indole-6-carb­oxy­lic acid, 5a(RS),6(SR),7(RS),9a(SR),9b(SR) and 5a(RS),6(RS),7(RS),9a(SR),9b(SR)

    PubMed Central

    Poplevin, Dmitry S.; Zubkov, Fedor I.; Dorovatovskii, Pavel V.; Zubavichus, Yan V.; Khrustalev, Victor N.

    2016-01-01

    The isomeric title compounds, C12H13NO4 (Ia) and C12H13NO4 (IIa), the products of an usual thermal C6-epimerization of 5-oxo-1,2,3,5,5a,6,7,9b-octa­hydro-7,9a-ep­oxy­pyrrolo­[2,1-a]iso­indole-6-carb­oxy­lic acid, represent the two different diastereomers and have very similar mol­ecular geometries. The mol­ecules of both compounds comprise a fused tetra­cyclic system containing four five-membered rings (pyrrolidine, pyrrolidinone, di­hydro­furan and tetra­hydro­furan), all of which adopt the usual envelope conformations. The dihedral angle between the basal planes of the pyrrolidine and pyrrolidinone rings are 14.3 (2) and 16.50 (11)°, respectively, for (Ia) and (IIa). The nitro­gen atom has a slightly pyramidalized geometry [bond-angle sum = 355.9 and 355.3°, for (Ia) and (IIa)], respectively. In the crystal of (Ia), mol­ecules form zigzag-like hydrogen-bonded chains along [010] through strong O—H⋯O hydrogen bonds and are further linked by weak C—H⋯O hydrogen bonds into complex two-tier layers parallel to (100). Unlike (Ia), the crystal of (IIa) contains centrosymmetric cyclic hydrogen-bonded dimers [graph set R 2 2(14)], formed through strong O—H⋯O hydrogen bonds and are further linked by weak C—H⋯O hydrogen bonds into ribbons extending across [101]. PMID:27746935

  19. 7. CONTEXTUAL VIEW NORTHEAST TOWARDS FEATURES 6 (LEFT) AND 7 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. CONTEXTUAL VIEW NORTHEAST TOWARDS FEATURES 6 (LEFT) AND 7 (RIGHT) WITHIN MILL COMPLEX. - Juniata Mill Complex, 22.5 miles Southwest of Hawthorne, between Aurora Crater & Aurora Peak, Hawthorne, Mineral County, NV

  20. 6 CFR 7.13 - Judicial proceedings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Judicial proceedings. 7.13 Section 7.13 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION... classified information (see 6 CFR 5.41 through 5.49), required to submit classified information for...

  1. 6 CFR 7.13 - Judicial proceedings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Judicial proceedings. 7.13 Section 7.13 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION... classified information (see 6 CFR 5.41 through 5.49), required to submit classified information for...

  2. Reaction of (chloro carbonyl) phenyl ketene with 5-amino pyrazolones: Synthesis, characterization and theoretical studies of 7-hydroxy-6-phenyl-3-(phenyldiazenyl)pyrazolo[1,5-a]pyrimidine-2,5(1H,4H)-dione derivatives

    NASA Astrophysics Data System (ADS)

    Zahedifar, Mahboobeh; Razavi, Razieh; Sheibani, Hassan

    2016-12-01

    New 7-hydroxy-6-phenyl-3-(phenyldiazenyl)pyrazolo[1,5-a]pyrimidine-2,5(1H,4H)-dione derivatives were synthesized from the reaction of (chlorocarbonyl)phenyl ketene and 5-amino pyrazolones in high to excellent yields and short reaction times. Structures of the new compounds were fully characterized by their spectral data IR, 1H NMR, and 13C NMR and by the theoretical results. Density Functional Theory (DFT) was used to optimize the structures, compute the energies and vibrational frequencies IR and 1H NMR shielding tensors of the desired products. The theoretical results excellent are compared with the experimental data.

  3. rac-1-[6-Hy-droxy-4-(4-meth-oxy-phen-yl)-3,6-dimethyl-4,5,6,7-tetra-hydro-2H-indazol-5-yl]ethanone.

    PubMed

    Potekhin, Konstantin A; Askerov, Rizvan K; Hajiyeva, Kushvar E; Gadirova, Narmina A; Nazarov, Shahkaram I

    2013-02-01

    The title compound, C(18)H(22)N(2)O(3), represents a (4S,5R,6S)-stereoisomer, crystallizing as a racemate in a centrosymmetric space group. The six-membered aliphatic ring adopts a half-chair conformation, with the hy-droxy- and acetyl-substituted C atoms deviating by 0.458 (2) and -0.366 (2) Å, respectively, from the plane defined by other four ring atoms. The pyrazole ring is essentially planar [r.m.s deviation = 0.004 (2) Å]. In the crystal, the mol-ecules are linked into chains along the b axis by N-H⋯N hydrogen bonds. The chains are linked by O-H⋯N hydrogen bonds into layers parallel to the bc plane. PMID:23424522

  4. Stress rotations due to the M6.5 foreshock and M7.3 main shock in the 2016 Kumamoto, SW Japan, earthquake sequence

    NASA Astrophysics Data System (ADS)

    Yoshida, Keisuke; Hasegawa, Akira; Saito, Tatsuhiko; Asano, Youichi; Tanaka, Sachiko; Sawazaki, Kaoru; Urata, Yumi; Fukuyama, Eiichi

    2016-10-01

    A shallow M7.3 event with a M6.5 foreshock occurred along the Futagawa-Hinagu fault zone in Kyushu, SW Japan. We investigated the spatiotemporal variation of the stress orientations in and around the source area of this 2016 Kumamoto earthquake sequence by inverting 1218 focal mechanisms. The results show that the σ3 axis in the vicinity of the fault plane significantly rotated counterclockwise after the M6.5 foreshock and rotated clockwise after the M7.3 main shock in the Hinagu fault segment. This observation indicates that a significant portion of the shear stress was released both by the M6.5 foreshock and M7.3 main shock. It is estimated that the stress release by the M6.5 foreshock occurred in the shallower part of the Hinagu fault segment, which brought the stress concentration in its deeper part. This might have caused the M7.3 main shock rupture mainly along the deeper part of the Hinagu fault segment after 28 h.

  5. Copper-catalyzed cascade cyclization of 1,7-enynes with aromatic sulfonyl chlorides toward selective assembly of benzo[j]phenanthridin-6(5H)-ones.

    PubMed

    Liu, Yu; Zhang, Jia-Ling; Zhou, Ming-Bo; Song, Ren-Jie; Li, Jin-Heng

    2014-11-28

    A step-economical method for the cascade cyclization of 1,7-enynes with aromatic sulfonyl chlorides by using a low-cost and more abundant Cu catalyst is presented. This method allows access to benzo[j]phenanthridin-6(5H)-ones and represents a new Cu-catalyzed cascade cyclization of 1,n-enynes. PMID:25300349

  6. 5-HT1A/1B, 5-HT6, and 5-HT7 serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: role of dorsal raphe nucleus.

    PubMed

    Freitas, Renato Leonardo; Ferreira, Célio Marcos dos Reis; Urbina, Maria Angélica Castiblanco; Mariño, Andrés Uribe; Carvalho, Andressa Daiane; Butera, Giuseppe; de Oliveira, Ana Maria; Coimbra, Norberto Cysne

    2009-05-01

    Pharmacological studies have been focused on the involvement of different neural pathways in the organization of antinociception that follows tonic-clonic seizures, including 5-hydroxytryptamine (5-HT)-, norepinephrine-, acetylcholine- and endogenous opioid peptide-mediated mechanisms, giving rise to more in-depth comprehension of this interesting post-ictal antinociceptive phenomenon. The present work investigated the involvement of 5-HT(1A/1B), 5-HT(6), and 5-HT(7) serotonergic receptors through peripheral pretreatment with methiothepin at doses of 0.5, 1.0, 2.0 and 3.0 mg/kg in the organization of the post-ictal antinociception elicited by pharmacologically (with pentylenetetrazole at 64 mg/kg)-induced tonic-clonic seizures. Methiothepin at 1.0 mg/kg blocked the post-ictal antinociception recorded after the end of seizures, whereas doses of 2.0 and 3.0 mg/kg potentiated the post-ictal antinociception. The nociceptive thresholds were kept higher than those of the control group. However, when the same 5-hydroxytryptamine receptors antagonist was microinjected (at 1.0, 3.0 and 5.0 microg/0.2 microL) in the dorsal raphe nucleus, a mesencephalic structure rich in serotonergic neurons and 5-HT receptors, the post-ictal hypo-analgesia was consistently antagonized. The present findings suggest a dual effect of methiothepin, characterized by a disinhibitory effect on the post-ictal antinociception when peripherally administered (possibly due to an antagonism of pre-synaptic 5-HT(1A) serotonergic autoreceptors in the pain endogenous inhibitory system) and an inhibitory effect (possibly due to a DRN post-synaptic 5-HT(1B), 5-HT(6), and 5-HT(7) serotonergic receptors blockade) when centrally administered. The present data also suggest that serotonin-mediated mechanisms of the dorsal raphe nucleus exert a key-role in the modulation of the post-ictal antinociception.

  7. X-ray Mapping in Heterocyclic Design: XIV. Tricyclic Heterocycles Based on 2-Oxo-1,2,5,6,7,8-Hexahydroquinoline-3-Carbonitrile

    SciTech Connect

    Mazina, O.S.; Rybakov, V.B.; Chernyshev, V.V.; Babaev, E.V.; Aslanov, L.A.

    2004-11-01

    The structures of four compounds are studied using single-crystal X-ray diffraction: 1-[2-(4-chlorophenyl)-2-oxoethyl]-2-oxo-1,2,5,6,7,8-hexahydroquinoline -3-carbonitrile [a = 4.908(4) A, b = 11.644(10) A, c = 13.587(2) A, {beta} = 94.31(5) deg., Z = 2, space group P2{sub 1}]; 2-[2-(4-chlorophenyl)-2-oxoethoxy]-5,6,7,8-tetrahydroquinoline -3-carbonitrile [a = 7.6142(8) A, b = 14.778(2) A, c = 14.132(2) A, {beta} = 100.38(1) deg., Z = 4, space group P2{sub 1}/c]; 4-(aminocarbonyl)-2-(chlorophenyl)-6,7,8,9-tetrahydro[1.3]oxazolo[3,2-a] quinolin-3-ium perchlorate [a = 5.589(7) A, b = 24.724(15) A, c = 13.727(5) A, {beta} = 97.66(9) deg., Z = 4, space group P2{sub 1}/n]; and (3-amino-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-2-yl)-(4-chlorophenyl) methanone [a = 7.150(2) A, b = 7.4288(10) A, c = 15.314(3) A, {alpha} = 98.030(10) deg., {beta} = 99.21(2) deg., {gamma} = 105.34(2) deg., Z = 2, space group P1-bar]. The structures are solved by direct methods and refined by the full-matrix least-squares procedure in the anisotropic approximation to R = 0.0728, 0.0439, 0.1228, and 0.0541, respectively. The structure of 1-(4-chlorophenyl)-4-piperidin-1-yl-8,9-dihydro-7H-pyrrolo[3.2.1-ij] quinoline-5-carboxamide [a = 23.9895(9) A, b = 5.1557(3) A, c = 17.0959(9) A, {beta} = 106.43 deg., Z = 4, space group P{sub 1}/c] is investigated by X-ray powder diffraction. This structure is solved using the grid search procedure and refined by the Rietveld method to R{sub wp} = 0.0773, R{sub exp} = 0.0540, R{sub p} = 0.0585, R{sub b} = 0.1107, and {chi}{sup 2} = 1.78.

  8. Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells.

    PubMed

    Shahinian, Hasmik; Loessner, Daniela; Biniossek, Martin L; Kizhakkedathu, Jayachandran N; Clements, Judith A; Magdolen, Viktor; Schilling, Oliver

    2014-02-01

    Kallikrein-related peptidases, in particular KLK4, 5, 6 and 7 (4-7), often have elevated expression levels in ovarian cancer. In OV-MZ-6 ovarian cancer cells, combined expression of KLK4-7 reduces cell adhesion and increases cell invasion and resistance to paclitaxel. The present work investigates how KLK4-7 shape the secreted proteome ("secretome") and proteolytic profile ("degradome") of ovarian cancer cells. The secretome comparison consistently identified >900 proteins in three replicate analyses. Expression of KLK4-7 predominantly affected the abundance of proteins involved in cell-cell communication. Among others, this includes increased levels of transforming growth factor β-1 (TGFβ-1). KLK4-7 co-transfected OV-MZ-6 cells share prominent features of elevated TGFβ-1 signaling, including increased abundance of neural cell adhesion molecule L1 (L1CAM). Augmented levels of TGFβ-1 and L1CAM upon expression of KLK4-7 were corroborated in vivo by an ovarian cancer xenograft model. The degradomic analysis showed that KLK4-7 expression mostly affected cleavage sites C-terminal to arginine, corresponding to the preference of kallikreins 4, 5 and 6. Putative kallikrein substrates include chemokines, such as growth differentiation factor 15 (GDF 15) and macrophage migration inhibitory factor (MIF). Proteolytic maturation of TGFβ-1 was also elevated. KLK4-7 have a pronounced, yet non-degrading impact on the secreted proteome, with a strong association between these proteases and TGFβ-1 signaling in tumor biology. PMID:24120346

  9. 7 CFR 370.6 - Appeals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 5 2011-01-01 2011-01-01 false Appeals. 370.6 Section 370.6 Agriculture Regulations... OF AGRICULTURE FREEDOM OF INFORMATION § 370.6 Appeals. If the request for information made under § 370.5 is denied in whole or in part, the requester may file an appeal pursuant to § 1.3(e) of...

  10. 7 CFR 370.6 - Appeals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 5 2014-01-01 2014-01-01 false Appeals. 370.6 Section 370.6 Agriculture Regulations... OF AGRICULTURE FREEDOM OF INFORMATION § 370.6 Appeals. If the request for information made under § 370.5 is denied in whole or in part, the requester may file an appeal pursuant to § 1.3(e) of...

  11. New metal-organic frameworks of [M(C{sub 6}H{sub 5}O{sub 7})(C{sub 6}H{sub 6}O{sub 7})(C{sub 6}H{sub 7}O{sub 7})(H{sub 2}O)] . H{sub 2}O (M=La, Ce) and [Ce{sub 2}(C{sub 2}O{sub 4})(C{sub 6}H{sub 6}O{sub 7}){sub 2}] . 4H{sub 2}O

    SciTech Connect

    Weng Shengfeng; Wang, Yun-Hsin; Lee, Chi-Shen

    2012-04-15

    Two novel materials, [M(C{sub 6}H{sub 5}O{sub 7})(C{sub 6}H{sub 6}O{sub 7})(C{sub 6}H{sub 7}O{sub 7})(H{sub 2}O)] . H{sub 2}O (M=La(1a), Ce(1b)) and [Ce{sub 2}(C{sub 2}O{sub 4})(C{sub 6}H{sub 6}O{sub 7}){sub 2}] . 4H{sub 2}O (2), with a metal-organic framework (MOF) were prepared with hydrothermal reactions and characterized with photoluminescence, magnetic susceptibility, thermogravimetric analysis and X-ray powder diffraction in situ. The crystal structures were determined by single-crystal X-ray diffraction. Compound 1 crystallized in triclinic space group P1-bar (No. 2); compound 2 crystallized in monoclinic space group P2{sub 1}/c (No. 14). The structure of 1 is built from a 1D MOF, composed of deprotonated citric ligands of three kinds. Compound 2 contains a 2D MOF structure consisting of citrate and oxalate ligands; the oxalate ligand arose from the decomposition in situ of citric acid in the presence of Cu{sup II} ions. Photoluminescence spectra of compounds 1b and 2 revealed transitions between the 5d{sup 1} excited state and two levels of the 4f{sup 1} ground state ({sup 2}F{sub 5/2} and {sup 2}F{sub 7/2}). Compounds 1b and 2 containing Ce{sup III} ion exhibit a paramagnetic property with weak antiferromagnetic interactions between the two adjacent magnetic centers. - Graphical Abstract: [M(C{sub 6}H{sub 5}O{sub 7})(C{sub 6}H{sub 6}O{sub 7})(C{sub 6}H{sub 7}O{sub 7})(H{sub 2}O)] . H{sub 2}O (M=La(1a), Ce(1b)) and [Ce{sub 2}(C{sub 2}O{sub 4})(C{sub 6}H{sub 6}O{sub 7}){sub 2}] . 4H{sub 2}O (2)-with 1D and 2D structures were synthesized and characterized. Highlights: Black-Right-Pointing-Pointer Two MOF - [M(C{sub 6}H{sub 5}O{sub 7})(C{sub 6}H{sub 6}O{sub 7})(C{sub 6}H{sub 7}O{sub 7})(H{sub 2}O)] . H{sub 2}O (M=La(1a), Ce(1b)) and [Ce{sub 2}(C{sub 2}O{sub 4})(C{sub 6}H{sub 6}O{sub 7}){sub 2}] . 4H{sub 2}O (2) - with 1D and 2D structures. Black-Right-Pointing-Pointer The adjacent chains of the 1D framework were correlated with each other through an oxalate

  12. 7 CFR 7.5 - Eligible voters.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Eligible voters. 7.5 Section 7.5 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF AGRICULTURAL STABILIZATION AND CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.5 Eligible voters. (a) Voters eligible to participate in:...

  13. Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.

    PubMed

    Oztürk Yildirim, Sema; Butcher, Ray J; Gündüz, Miyase Gözde; El-Khouly, Ahmed; Simşek, Rahime; Safak, Cihat

    2013-01-01

    In the title mol-ecule, C24H28N2O3, the cyclo-hexene ring is in a sofa conformation and the 1,4-dihydro-pyridine ring is in a slight boat conformation. In the indole ring system, the pyrrole and benzene rings form a dihedral angle of 2.63 (7)°. In the crystal, N-H⋯O hydrogen bonds connect the mol-ecules into C(6) chains parallel to the b axis and pairs of weak C-H⋯O hydrogen bonds link inversion-related chains into a ladder motif through R2(2)(18) rings. A weak intra-molecular C-H⋯O hydrogen bond is also observed. PMID:23476426

  14. Rotational spectrum and carbon-13 hyperfine structure of the C3H, C5H, C6H, and C7H radicals.

    PubMed

    McCarthy, M C; Thaddeus, P

    2005-05-01

    By means of Fourier transform microwave spectroscopy of a supersonic molecular beam, we have detected the singly substituted carbon-13 isotopic species of C(5)H, C(6)H, and C(7)H. Hyperfine structure in the rotational transitions of the lowest-energy fine structure component ((2)Pi(12) for C(5)H and C(7)H, and (2)Pi(32) for C(6)H) of each species was measured between 6 and 22 GHz, and precise rotational, centrifugal distortion, Lambda-doubling, and (13)C hyperfine coupling constants were determined. In addition, resolved hyperfine structure in the lowest rotational transition (J = 32-->12) of the three (13)C isotopic species of C(3)H was measured by the same technique. By combining the centimeter-wave measurements here with previous millimeter-wave data, a complete set of (13)C hyperfine coupling constants were derived to high precision for each isotopic species. Experimental structures (r(0)) have been determined for C(5)H and the two longer carbon-chain radicals, and these are found to be in good agreement with the predictions of high-level coupled-cluster calculations. C(3)H, C(5)H, and C(7)H exhibit a clear alternation in the magnitude and sign of the (13)C hyperfine coupling constants along the carbon-chain backbone. Because the electron spin density is nominally zero at the central carbon atom of C(3)H, C(5)H, and C(7)H, and at alternating sets of carbon atoms of C(5)H and C(7)H, owing to spin polarization, almost all of the (13)C coupling constants at these atoms are small in magnitude and negative in sign. Spin-polarization effects are known to be important for the Fermi-contact (b(F)) term, but prior to the work here they have generally been neglected for the hyperfine terms a, c, and d.

  15. Suppression of Adipogenesis by 5-Hydroxy-3,6,7,8,3',4'-Hexamethoxyflavone from Orange Peel in 3T3-L1 Cells.

    PubMed

    Wang, Yu; Lee, Pei-Sheng; Chen, Yi-Fen; Ho, Chi-Tang; Pan, Min-Hsiung

    2016-09-01

    We reported previously that hydroxylated polymethoxyflavones (HPMFs) effectively suppressed obesity in high-fat-induced mouse. In this study, we further investigated the molecular mechanism of action of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF), one of major HPMFs in orange peel. Treatment of 5-OH-HxMF effectively inhibited lipid accumulation by 55-60% in a dose-dependent manner. The 5-OH-HxMF attenuated adipogenesis through downregulating adipogenesis-related transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding proteins (C/EBPs), as well as downstream target fatty acid synthase and acetyl-CoA carboxylase (ACC). 5-OH-HxMF activated adenosine monophosphate-activated protein kinase signaling and silent mating type information regulation 1 (SIRTUIN 1 or SIRT1) in 3T3-L1 adipocytes to decrease lipid accumulation. In addition, the inhibition rate of lipid accumulation was compared between 5-OH-HxMF and 3,5,6,7,8,3',4'-heptamethoxyflavone (HpMF). 5-OH-HxMF inhibited lipid accumulation 15-20% more than HpMF did, indicating that hydroxyl group at position 5 can be a key factor in the suppression of adipogenesis. PMID:27542074

  16. Synthesis, structure, and bonding of Sc4MgxCu15-xGa approximately 7.5 (x=0, 0.5). Two incommensurately modulated scandium substitution derivatives of cubic Mg2Cu6Ga5.

    PubMed

    Lin, Qisheng; Lidin, Sven; Corbett, John D

    2008-02-01

    The substitution of scandium for magnesium in Mg2Cu6Ga5 (Mg2Zn11-type) yields an irrational superstructure phase that includes the refined compositions, Sc4Mg0.50(2)Cu14.50(2)Ga7.61(2) and Sc4Cu14.76(2)Ga7.51(2). These crystallize in Cmmm, a=approximately 8.31 A, b=approximately 21.72 A, c=approximately 8.30 A. The structures feature Sc2 dimers, Cu6 octahedra, a 3D CuGa (Cu12Ga2) framework, and arachno gallium-centered Cu4Ga6 icosahedra that are condensed into zigzag chains. The arrangement of these building blocks exhibits a topologic relationship to Mg2Cu6Ga5. Further studies reveal that the quaternary compound exhibits incommensurate modulations along a, with q=(0.694, 0, 0). Structure refinements with superspace group Xmmm(a00)000 led to saw-tooth modulations for two fractional or mixed sites that avoid short Cu-Ga distances. Band structure analyses reveal that the Fermi surface and bonding are sensitive to the incommensurately modulated atoms. PMID:18163612

  17. The epithelial differentiating activity in vivo of (E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl) -1-propenyl]benzoic acid and 4,4-difluororetinoic acid.

    PubMed Central

    Miller, D A; Stephens-Jarnagin, A; DeLuca, H F

    1985-01-01

    Female rats fed on a vitamin A-deficient diet from weaning were oophorectomized after introitus and used to test analogues of all-trans-retinoic acid for epithelial differentiation activity by the vaginal-smear assay. Several modifications have been made in the assay; housing facilities were modified, the diet changed and the existing scoring system for the assay altered. The arotinoid (E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl)-1 -propenyl] benzoic acid was 12-fold more active than all-trans-retinoic acid, which had a 50% effective dose (ED50) of 80 pmol/vagina. The fluorinated analogue 4,4-difluororetinoic acid had an ED50 of 2.5 nmol/vagina and was therefore 30-fold less active than all-trans-retinoic acid. PMID:3994687

  18. The galaxy luminosity function at z ≃ 6 and evidence for rapid evolution in the bright end from z ≃ 7 to 5

    NASA Astrophysics Data System (ADS)

    Bowler, R. A. A.; Dunlop, J. S.; McLure, R. J.; McCracken, H. J.; Milvang-Jensen, B.; Furusawa, H.; Taniguchi, Y.; Le Fèvre, O.; Fynbo, J. P. U.; Jarvis, M. J.; Häußler, B.

    2015-09-01

    We present the results of a search for bright (-22.7 ≤ MUV ≤ -20.5) Lyman-break galaxies at z ≃ 6 within a total of 1.65 deg2 of imaging in the UltraVISTA/Cosmological Evolution Survey (COSMOS) and United Kingdom Infrared Telescope Deep Sky Survey (UKIDSS) Ultra Deep Survey (UDS) fields. The deep near-infrared imaging available in the two independent fields, in addition to deep optical (including z'-band) data, enables the sample of z ≃ 6 star-forming galaxies to be securely detected longward of the break (in contrast to several previous studies). We show that the expected contamination rate of our initial sample by cool Galactic brown dwarfs is ≲3 per cent and demonstrate that they can be effectively removed by fitting brown dwarf spectral templates to the photometry. At z ≃ 6, the galaxy surface density in the UltraVISTA field exceeds that in the UDS by a factor of ≃ 1.8, indicating strong cosmic variance even between degree-scale fields at z > 5. We calculate the bright end of the rest-frame Ultraviolet (UV) luminosity function (LF) at z ≃ 6. The galaxy number counts are a factor of ˜1.7 lower than predicted by the recent LF determination by Bouwens et al. In comparison to other smaller area studies, we find an evolution in the characteristic magnitude between z ≃ 5 and z ≃ 7 of ΔM* ˜ 0.4, and show that a double power law or a Schechter function can equally well describe the LF at z = 6. Furthermore, the bright end of the LF appears to steepen from z ≃ 7 to z ≃ 5, which could indicate the onset of mass quenching or the rise of dust obscuration, a conclusion supported by comparing the observed LFs to a range of theoretical model predictions.

  19. The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes

    PubMed Central

    Cooper, Jason D; Smyth, Deborah J; Bailey, Rebecca; Payne, Felicity; Downes, Kate; Godfrey, Lisa M; Masters, Jennifer; Zeitels, Lauren R; Vella, Adrian; Walker, Neil M; Todd, John A

    2007-01-01

    Background As genes associated with immune-mediated diseases have an increased prior probability of being associated with other immune-mediated diseases, we tested three such genes, IL23R, IRF5 and CD40, for an association with type 1 diabetes. In addition, we tested seven genes, TAF5L, PDCD1, TCF7, IL12B, IL6, ICAM1 and TBX21, with published marginal or inconsistent evidence of an association with type 1 diabetes. Methods We genotyped reported polymorphisms of the ten genes, nonsynonymous SNPs (nsSNPs) and, for the IL12B and IL6 regions, tag SNPs in up to 7,888 case, 8,858 control and 3,142 parent-child trio samples. In addition, we analysed data from the Wellcome Trust Case Control Consortium genome-wide association study to determine whether there was any further evidence of an association in each gene region. Results We found some evidence of associations between type 1 diabetes and TAF5L, PDCD1, TCF7 and IL6 (ORs = 1.05 – 1.13; P = 0.0291 – 4.16 × 10-4). No evidence of an association was obtained for IL12B, IRF5, IL23R, ICAM1, TBX21 and CD40, although there was some evidence of an association (OR = 1.10; P = 0.0257) from the genome-wide association study for the ICAM1 region. Conclusion We failed to exclude the possibility of some effect in type 1 diabetes for TAF5L, PDCD1, TCF7, IL6 and ICAM1. Additional studies, of these and other candidate genes, employing much larger sample sizes and analysis of additional polymorphisms in each gene and its flanking region will be required to ascertain their contributions to type 1 diabetes susceptibility. PMID:18045485

  20. New detections of HC5N towards hot cores associated with 6.7 GHz methanol masers

    NASA Astrophysics Data System (ADS)

    Green, C.-E.; Green, J. A.; Burton, M. G.; Horiuchi, S.; Tothill, N. F. H.; Walsh, A. J.; Purcell, C. R.; Lovell, J. E. J.; Millar, T. J.

    2014-09-01

    We present new detections of cyanodiacetylene (HC5N) towards hot molecular cores, observed with the Tidbinbilla 34 m radio telescope (DSS-34). In a sample of 79 hot molecular cores, HC5N was detected towards 35. These results are counter to the expectation that long chain cyanopolyynes, such as HC5N, are not typically found in hot molecular cores, unlike their shorter chain counterpart HC3N. However, it is consistent with recent models which suggest HC5N may exist for a limited period during the evolution of hot molecular cores.

  1. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. [Tetrahydropyrene and hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H[sub 2] hydrogenation reaction network.

  2. 7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.

    PubMed

    D'Erasmo, Michael P; Smith, William B; Munoz, Alberto; Mohandas, Poornima; Au, Andrew S; Marineau, Jason J; Quadri, Luis E N; Bradner, James E; Murelli, Ryan P

    2014-08-15

    7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic butenolides that can be generated rapidly and as a single diastereomer through a cascade process between γ-hydroxybutenolides and aromatic aldehydes. The following outlines our findings that these spirocycles are potently cytotoxic and have a dramatic structure-function profile that provides excellent insight into the structural features required for this potency.

  3. 7 CFR 331.6 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 5 2013-01-01 2013-01-01 false 331.6 Section 331.6 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE POSSESSION, USE, AND TRANSFER OF SELECT AGENTS AND TOXINS § 331.6...

  4. 7 CFR 331.6 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false 331.6 Section 331.6 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE POSSESSION, USE, AND TRANSFER OF SELECT AGENTS AND TOXINS § 331.6...

  5. 7 CFR 331.6 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 5 2014-01-01 2014-01-01 false 331.6 Section 331.6 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE POSSESSION, USE, AND TRANSFER OF SELECT AGENTS AND TOXINS § 331.6...

  6. 7 CFR 331.6 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false 331.6 Section 331.6 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE POSSESSION, USE, AND TRANSFER OF SELECT AGENTS AND TOXINS § 331.6...

  7. 7 CFR 371.6 - Wildlife Services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Wildlife Services. 371.6 Section 371.6 Agriculture..., DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND DELEGATIONS OF AUTHORITY § 371.6 Wildlife Services. (a) General statement. Wildlife Services (WS) manages problems caused by wildlife. (b) Deputy Administrator...

  8. 7 CFR 371.6 - Wildlife Services.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 5 2011-01-01 2011-01-01 false Wildlife Services. 371.6 Section 371.6 Agriculture..., DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND DELEGATIONS OF AUTHORITY § 371.6 Wildlife Services. (a) General statement. Wildlife Services (WS) manages problems caused by wildlife. (b) Deputy Administrator...

  9. 7 CFR 371.6 - Wildlife Services.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 5 2014-01-01 2014-01-01 false Wildlife Services. 371.6 Section 371.6 Agriculture..., DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND DELEGATIONS OF AUTHORITY § 371.6 Wildlife Services. (a) General statement. Wildlife Services (WS) manages problems caused by wildlife. (b) Deputy Administrator...

  10. 7 CFR 371.6 - Wildlife Services.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Wildlife Services. 371.6 Section 371.6 Agriculture..., DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND DELEGATIONS OF AUTHORITY § 371.6 Wildlife Services. (a) General statement. Wildlife Services (WS) manages problems caused by wildlife. (b) Deputy Administrator...

  11. 7 CFR 371.6 - Wildlife Services.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 5 2013-01-01 2013-01-01 false Wildlife Services. 371.6 Section 371.6 Agriculture..., DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND DELEGATIONS OF AUTHORITY § 371.6 Wildlife Services. (a) General statement. Wildlife Services (WS) manages problems caused by wildlife. (b) Deputy Administrator...

  12. Diphlorethohydroxycarmalol Inhibits Interleukin-6 Production by Regulating NF-κB, STAT5 and SOCS1 in Lipopolysaccharide-Stimulated RAW264.7 Cells

    PubMed Central

    Kang, Na-Jin; Han, Sang-Chul; Kang, Gyeoung-Jin; Koo, Dong-Hwan; Koh, Young-Sang; Hyun, Jin-Won; Lee, Nam-Ho; Ko, Mi-Hee; Kang, Hee-Kyoung; Yoo, Eun-Sook

    2015-01-01

    Diphlorethohydroxycarmalol (DPHC) is a phlorotannin compound isolated from Ishige okamuarae, a brown alga. This study was conducted to investigate the anti-inflammatory effect and action mechanism of DPHC in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. We found that DPHC strongly reduces the production of interleukin 6 (IL-6), but not that of tumor necrosis factor-alpha (TNF-α) induced by LPS. DPHC (12.5 and 100 μM) suppressed the phosphorylation and the nuclear translocation of NF-kappaB (NF-κB), a central signaling molecule in the inflammation process induced by LPS. The suppressor of cytokine signaling 1 (SOCS1) is a negative feedback regulator of Janus kinase (Jak)-signal transducer and activator of transcription (STAT) signaling. In this study, DPHC inhibited STAT5 expression and upregulated that of SOCS1 at a concentration of 100 μM. Furthermore, N-tosyl-l-phenylalanine chloromethyl ketone (TPCK) (a specific NF-κB inhibitor) and JI (a specific Jak2 inhibitor) reduced the production of IL-6, but not that of tumor necrosis factor-alpha (TNF-α) in LPS-stimulated RAW 264.7 macrophages. These findings demonstrate that DPHC inhibits IL-6 production via the downregulation of NF-κB and Jak2-STAT5 pathway and upregulation of SOCS1. PMID:25871292

  13. Target and beam-target spin asymmetries in exclusive π+ and π– electroproduction with 1.6- to 5.7-GeV electrons

    DOE PAGES

    Bosted, P. E.; Biselli, A. S.; Careccia, S.; Dodge, G.; Fersch, R.; Guler, N.; Kuhn, S. E.; Pierce, J.; Prok, Y.; Zheng, X.; et al

    2016-11-01

    Here, beam-target double-spin asymmetries and target single-spin asymmetries in exclusive π+ and quasiexclusive π– electroproduction were obtained from scattering of 1.6- to 5.7-GeV longitudinally polarized electrons from longitudinally polarized protons (for π+) and deuterons (for π–) using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab. The kinematic range covered is 1.1 < W < 2.6 GeV and 0.05 < Q2 < 5GeV2, with good angular coverage in the forward hemisphere. The asymmetry results were divided into approximately 40 000 kinematic bins for π+ from free protons and 15 000 bins for π– production from bound nucleons in the deuteron.more » The present results are found to be in reasonable agreement with fits to previous world data for W < 1.7 GeV and Q2 < 0.5GeV2, with discrepancies increasing at higher values of Q2, especially for W > 1.5 GeV. Very large target-spin asymmetries are observed for W > 1.6 GeV. When combined with cross-section measurements, the present results can provide powerful constraints on nucleon resonance amplitudes at moderate and large values of Q2, for resonances with masses as high as 2.3 GeV.« less

  14. CryoEM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

    PubMed Central

    Bai, Xiao-chen; Oubridge, Chris; Newman, Andrew J.; Scheres, Sjors H. W.; Nagai, Kiyoshi

    2016-01-01

    U4/U6.U5 tri-snRNP represents a substantial part of the spliceosome before activation. A cryoEM structure of Saccharomyces cerevisiae U4/U6.U5 tri-snRNP at 3.7Å resolution led to an essentially complete atomic model comprising 30 proteins plus U4/U6 and U5 snRNAs. The structure reveals striking interweaving interactions of the protein and RNA components including extended polypeptides penetrating into subunit interfaces. The invariant ACAGAGA sequence of U6 snRNA, which base-pairs with the 5′-splice site during catalytic activation, forms a hairpin stabilised by Dib1 and Prp8 while the adjacent nucleotides interact with the exon binding loop 1 of U5 snRNA. Snu114 harbours GTP but its putative catalytic histidine is held away from the γ-phosphate by hydrogen bonding to a tyrosine in Prp8’s N-terminal domain. Mutation of this histidine to alanine has no detectable effect on yeast growth. The structure provides important new insights into the spliceosome activation process leading to the formation of the catalytic centre. PMID:26829225

  15. Synthesis and Application of 1,3,4,5,7,8-Hexafluorotetracyanonaphthoquinodimethane (F6-TNAP): A Conductivity Dopant for Organic Light-Emitting Devices

    SciTech Connect

    Koech, Phillip K.; Padmaperuma, Asanga B.; Wang, Liang; Swensen, James S.; Polikarpov, Evgueni; Darsell, Jens T.; Rainbolt, James E.; Gaspar, Daniel J.

    2010-07-13

    We report the synthesis, photophysical and organic light-emitting device (OLED) properties of an organic molecular p-dopant 1,3,4,5,7,8-hexafluorotetracyanonaphthoquinodimethane (F6-TNAP). F6-TNAP was obtained in a three step 2 pot synthesis from commercially available octafluoronaphthalene. Doping effect of F6-TNAP was evaluated using films of 1-5% F6-TNAP with N,N'-di-1-naphthyl-N,N'-diphenyl-1,1'-biphenyl-4,4'diamineα-NPD) co-evaporated on quartz. UV-vis analysis of these films showed an absorption peak at 950 nm corresponding to the charge transfer complex resulting from electron transfer from α-NPD to F6-TNAP. Hole only devices using α-NPD as the hole transport layer (HTL) doped with F6-TNAP show greater than 2V decrease in operating voltage compared to the undoped device. A decrease in operating voltage was also demonstrated in blue OLED devices using F6-TNAP doped HTL, with a slight decrease in external quantum efficiency (EQE), thus resulting in a net improvement in power efficiency.

  16. Identification and genetic definition of a bovine papillomavirus type 1 E7 protein and absence of a low-copy-number phenotype exhibited by E5, E6, or E7 viral mutants.

    PubMed Central

    Jareborg, N; Alderborn, A; Burnett, S

    1992-01-01

    The bovine papillomavirus type 1 (BPV-1) genome replicates as a multiple-copy plasmid in murine C127 cells transformed to neoplasia by virus infection or by transfection with BPV-1 DNA. It was reported previously that BPV-1 genomes harboring frameshift mutations in the E6 or E7 open reading frame (ORF) replicated in C127 cells transformed by these mutants at a low copy number. Furthermore, the characterization of a BPV-1 mRNA in which the E6 and E7 ORFs were spliced together in frame has led to the assumption that an E6/7 fusion protein is expressed in virus-transformed C127 cells. To define the number and nature of the E6 and E7 gene products expressed in BPV-1-transformed cells, we performed immunoprecipitation experiments with antisera raised to bacterially expressed BPV-1 E6 and E7 fusion proteins. By employing cell culture conditions which induce BPV-1 E2 transactivator expression and viral early region transcription in virus-transformed C127 cell lines, we detected a single immunoprecipitated E6 protein species with an apparent molecular mass of 17 kDa and a single E7 protein species with an apparent molecular mass of 15 kDa. To characterize further these E6 and E7 proteins, C127 cells were transformed by transfection with BPV-1 genomes containing mutations predicted to prevent expression of specific E6 or E7 gene products, and the transformed cells were subjected to immunoprecipitation analysis with the E6 or E7 antiserum. The results of these experiments confirmed that the E6 and E7 ORFs encode distinct proteins and failed to establish the existence of an E6/7 fusion protein. We did not find a significant difference in the viral genome copy number between clonal C127 cell lines transformed by wild-type BPV-1 or by mutant viral genomes unable to express the E6 or the E7 protein. Furthermore, in contrast to two previous reports suggesting that expression of the BPV-1 E5 gene was required for the establishment or maintenance of a high viral plasmid copy number

  17. Synthesis, characterization, and energetic properties of 6-amino-tetrazolo[1,5-b]-1,2,4,5-tetrazine-7-N-oxide: a nitrogen-rich material with high density.

    PubMed

    Wei, Hao; Zhang, Jiaheng; Shreeve, Jean'ne M

    2015-05-01

    The synthesis and energetic properties of a novel N-oxide high-nitrogen compound, 6-amino-tetrazolo[1,5-b]-1,2,4,5-tetrazine-7-N-oxide, are described. Resulting from the N-oxide and fused rings system, this molecule exhibits high density, excellent detonation properties, and acceptable impact and friction sensitivities, which suggests potential applications as an energetic material. Compared to known high-nitrogen compounds, such as 3,6-diazido-1,2,4,5-tetrazine (DiAT), 2,4,6-tri(azido)-1,3,5-triazine (TAT), and 4,4',6,6'-tetra(azido)azo-1,3,5-triazine (TAAT), a marked performance and stability increase is seen. This supports the superior qualities of this new compound and the advantage of design strategy.

  18. Global emission estimates and radiative impact of C4F10, C5F12, C6F14, C7F16 and C8F18

    NASA Astrophysics Data System (ADS)

    Ivy, D. J.; Rigby, M.; Baasandorj, M.; Burkholder, J. B.; Prinn, R. G.

    2012-08-01

    Global emission estimates based on new atmospheric observations are presented for the acylic high molecular weight perfluorocarbons (PFCs): decafluorobutane (C4F10), dodecafluoropentane (C5F12), tetradecafluorohexane (C6F14), hexadecafluoroheptane (C7F16) and octadecafluorooctane (C8F18). Emissions are estimated using a 3-dimensional chemical transport model and an inverse method that includes a growth constraint on emissions. The observations used in the inversion are based on newly measured archived air samples that cover a 39-yr period, from 1973 to 2011, and include 36 Northern Hemispheric and 46 Southern Hemispheric samples. The derived emission estimates show that global emission rates were largest in the 1980s and 1990s for C4F10 and C5F12, and in the 1990s for C6F14, C7F16 and C8F18. After a subsequent decline, emissions have remained relatively stable, within 20%, for the last 5 yr. Bottom-up emission estimates are available from the Emission Database for Global Atmospheric Research version 4.2 (EDGARv4.2) for C4F10, C5F12, C6F14 and C7F16, and inventories of C4F10, C5F12 and C6F14 are reported to the United Nations' Framework Convention on Climate Change (UNFCCC) by Annex 1 countries that have ratified the Kyoto Protocol. The atmospheric measurement-based emission estimates are 20 times larger than EDGARv4.2 for C4F10 and over three orders of magnitude larger for C5F12 (with 2008 EDGARv4.2 estimates for C5F12 at 9.6 kg yr-1, as compared to 67±53 t yr-1 as derived in this study). The derived emission estimates for C6F14 largely agree with the bottom-up estimates from EDGARv4.2. Moreover, the C7F16 emission estimates are comparable to those of EDGARv4.2 at their peak in the 1990s, albeit significant underestimation for the other time periods. There are no bottom-up emission estimates for C8F18, thus the emission rates reported here are the first for C8F18. The reported inventories for C4F10, C5F12 and C6F14 to UNFCCC are five to ten times lower than those

  19. 7 CFR 7.5 - Eligible voters.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Eligible voters. 7.5 Section 7.5 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF FARM SERVICE AGENCY STATE AND COUNTY... race, color, national origin, gender, religion, age, disability, political beliefs, sexual...

  20. 7 CFR 7.5 - Eligible voters.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Eligible voters. 7.5 Section 7.5 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF FARM SERVICE AGENCY STATE AND COUNTY... race, color, national origin, gender, religion, age, disability, political beliefs, sexual...

  1. Cox Decompression Manipulation and Guided Rehabilitation of a Patient With a Post Surgical C6-C7 Fusion With Spondylotic Myelopathy and Concurrent L5-S1 Radiculopathy

    PubMed Central

    Joachim, George C.

    2014-01-01

    Objective The purpose of this case report is to describe combined treatment utilizing Cox distraction manipulation and guided rehabilitation for a patient with spine pain and post-surgical C6-7 fusion with spondylotic myelopathy and L5-S1 radiculopathy. Clinical features A 38-year-old man presented to a chiropractic clinic with neck pain and a history of an anterior cervical spine plate fusion at C6-7 after a work related accident 4 years earlier. He had signs and symptoms of spondolytic myelopathy and right lower back, right posterior thigh pain and numbness. Intervention and outcome The patient was treated with Cox technique and rehabilitation. The patient experienced a reduction of pain on a numeric pain scale from 8/10 to 3/10. The patient was seen a total of 12 visits over 3 months. No adverse effects were reported. Conclusions A patient with a prior C6-7 fusion with spondylotic myelopathy and concurrent L5-S1 radiculopathy improved after a course of rehabilitation and Cox distraction manipulation. Further research is needed to establish its efficiency. PMID:25685119

  2. Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII.P22/GII.5, GII.P7/GII.6 and GII.Pg/GII.1.

    PubMed

    Hernandez, Juliana das Merces; da Silva, Luciana Damascena; Sousa Junior, Edivaldo Costa; de Lucena, Maria Silvia Souza; Soares, Luana da Silva; Mascarenhas, Joana D'Arc Pereira; Gabbay, Yvone Benchimol

    2016-04-01

    Norovirus (NoV) is responsible for outbreaks and sporadic cases of nonbacterial acute gastroenteritis in humans worldwide. The virus consists of small round particles containing a single-stranded RNA genome that is divided into three Open Reading Frames. NoV evolves via mechanisms of antigenic drift and recombination, which lead to the emergence of new strains that are capable of causing global epidemics. Recombination usually occurs in the ORF1/ORF2 overlapping region and generates strains with different genotypes in the polymerase and capsid region. The primary objective of this study was to analyze recombination in positive-NoV samples. Specimens were collected during 2011, 2012 and 2014, from children under two years of age presenting gastrointestinal symptoms such as vomiting and diarrhea. The partial polymerase (B region), capsid (D region) genes and the ORF1-ORF2 overlap regions were sequenced in each sample. The recombinant analyses were performed in the Simplot software v.3.5.1 and RDP4 Beta v. 4.6 program. These analyses showed that GII.Pg/GII.1, GII.P7/GII.6, and GII.P22/GII.5 were recombinant strains. To our knowledge, this is the first time that the GII.P22/GII.5 and GII.Pg/GII.1 strains were described in South America and the GII.P7/GII.6 was detected in Northern of Brazil.

  3. Degradation of alpha-pinene oxide and [2H7]-2,5,6-trimethyl-hept-(2E)-enoic acid by Pseudomonas fluorescens NCIMB 11761.

    PubMed

    Zorn, H; Neuser, F; Berger, R G

    2004-02-01

    When submerged cultured Pseudomonas fluorescens NCIMB 11761 was fed-batch supplemented with alpha-pinene oxide, a rapid formation of 2,6-dimethyl-5-methylene-hept-(2Z)-enal (I) (isonovalal) was observed. Biotransformation and isomerisation of (I) to the (2E)-isomer (II) (novalal) were enhanced by Lewatit OC 1064, a macroporous polystyrene adsorbent. Accelerated isomerisation in the presence of an amino donor (glycine) at pH 7.3 pointed to a merely chemical mechanism. A maximum yield of 48 g of aldehydesl(-1) was achieved, but quantitative analysis of the volatile fraction showed that the molar conversion of the pinene oxide substrate reached no more than 67%. To fill this gap of the mass balance, the acidic fraction was isolated. It contained several compounds which suggested a beta-oxidation-like catabolism starting from 2,6-dimethyl-5-methylene-hept-(2E)-enoic acid (III) (novalic acid). Using [2H7]-2,5,6-dimethyl-hept-(2E)-enoic acid as a conversion substrate and gas chromatography coupled to atomic emission detection and mass spectrometry a degradation pathway via labelled 3,4-dimethylpentenoic and methylpropanoic acids was evidenced. This pathway may play a predominant role in isoprenoid degradation by soil bacteria.

  4. Sterol biosynthesis: strong inhibition of maize delta 5,7-sterol delta 7-reductase by novel 6-aza-B-homosteroids and other analogs of a presumptive carbocationic intermediate of the reduction reaction.

    PubMed

    Rahier, A; Taton, M

    1996-06-01

    A series of mono- and diazasteroids have been synthesized as analogs of a predicted carbocationic intermediate of delta 5,7-sterol delta 7-reductase (delta 7-SR). 6-Aza-B-homo-5 alpha-cholest-7-en-3 beta-ol (4), a novel compound whose synthesis is described for the first time, and 6,7-diaza-5 alpha-cholest-8(14)-en-3 beta-ol (6) were shown to be very powerful inhibitors of delta 7-SR in a preparation isolated from maize (Zea mays) (K(i),app = 50-70 nM, Ki,app/Km,app = 1.0 x 10(-4) to 1.3 x 10(-4). The data are consistent with a carbonium ion mechanism for the reduction; compounds 4 and 6 probably act as reaction intermediate analogs. Compound 4, in contrast to compound 6, displayed in the same microsomal preparation more than 50-fold selectivity for inhibition of the delta 7-SR versus delta 8-delta 7-sterol isomerase, cycloeucalenol isomerase, and delta 8,14-sterol delta 14-reductase, the mechanism of these four enzymes involving presumptive cationic intermediates centered respectively at C7, C8, C9, and C14. These observations highlight the paramount importance of the location of the positively charged nitrogen atom(s) in the B-ring structure for selectivity among these enzymes involving structurally close cationic reaction intermediates. Efficient in vivo inhibition of sterol biosynthesis in bramble cell suspension cultures by a low concentration of compound 4 was demonstrated and confirmed the in vitro properties of this derivative.) PMID:8679532

  5. Global emission estimates and radiative impact of C4F10, C5F12, C6F14, C7F16 and C8F18

    NASA Astrophysics Data System (ADS)

    Ivy, D. J.; Rigby, M.; Baasandorj, M.; Burkholder, J. B.; Prinn, R. G.

    2012-05-01

    Global emission estimates based on new atmospheric observations are presented for the acylic high molecular weight perfluorocarbons (PFCs): decafluorobutane (C4F10), dodecafluoropentane (C5F12), tetradecafluorohexane (C6F14), hexadecafluoroheptane (C7F16) and octadecafluorooctane (C8F18). Emissions are estimated using a 3-dimensional chemical transport model and an inverse method that includes a growth constraint on emissions. The observations used in the inversion are based on newly measured archived air samples that cover a 39-yr period, from 1973 to 2011, and include 36 Northern Hemispheric and 46 Southern Hemispheric samples (Ivy et al., 2012). The derived emission estimates show that global emission rates were largest in the 1980s and 1990s for C4F10 and C5F12, and in the 1990s for C6F14,C7F16 and C8F18. After a subsequent decline, emissions have remained relatively stable, within 20%, for the last 5 yr. Bottom-up emission estimates are available from the Emission Database for Global Atmospheric Research version 4.2 (EDGARv4.2) for C4F10, C5F12, C6F14 and C7F16, and inventories of C4F10, C5F12 andC6F14 are reported to the United Nations' Framework Convention on Climate Change (UNFCCC) by Annex 1 countries that have ratified the Kyoto Protocol. The atmospheric measurement based emission estimates are 20 times larger than EDGARv4.2 for C4F10 and over three orders of magnitude for C5F12. The derived emission estimates for C6F14 largely agree with the bottom-up estimates from EDGARv4.2. Moreover, the C7F16 emission estimates are comparable to those of EDGARv4.2 at their peak in the 1990s, albeit significant underestimation for the other time periods. There are no bottom-up emission estimates for C8F18, thus the emission rates reported here are the first for C8F18. The reported inventories for C4F10, C5F12 and C6F14 to UNFCCC are five to ten times lower than those estimated in this study. In addition, we present measured infrared absorption spectra for C7F16 and C8

  6. 3.6 and 4.5 μm Spitzer Phase Curves of the Highly Irradiated Hot Jupiters WASP-19b and HAT-P-7b

    NASA Astrophysics Data System (ADS)

    Wong, Ian; Knutson, Heather A.; Kataria, Tiffany; Lewis, Nikole K.; Burrows, Adam; Fortney, Jonathan J.; Schwartz, Joel; Shporer, Avi; Agol, Eric; Cowan, Nicolas B.; Deming, Drake; Désert, Jean-Michel; Fulton, Benjamin J.; Howard, Andrew W.; Langton, Jonathan; Laughlin, Gregory; Showman, Adam P.; Todorov, Kamen

    2016-06-01

    We analyze full-orbit phase curve observations of the transiting hot Jupiters WASP-19b and HAT-P-7b at 3.6 and 4.5 μm, obtained using the Spitzer Space Telescope. For WASP-19b, we measure secondary eclipse depths of 0.485%+/- 0.024% and 0.584%+/- 0.029% at 3.6 and 4.5 μm, which are consistent with a single blackbody with effective temperature 2372 ± 60 K. The measured 3.6 and 4.5 μm secondary eclipse depths for HAT-P-7b are 0.156%+/- 0.009% and 0.190%+/- 0.006%, which are well described by a single blackbody with effective temperature 2667 ± 57 K. Comparing the phase curves to the predictions of one-dimensional and three-dimensional atmospheric models, we find that WASP-19b’s dayside emission is consistent with a model atmosphere with no dayside thermal inversion and moderately efficient day-night circulation. We also detect an eastward-shifted hotspot, which suggests the presence of a superrotating equatorial jet. In contrast, HAT-P-7b’s dayside emission suggests a dayside thermal inversion and relatively inefficient day-night circulation; no hotspot shift is detected. For both planets, these same models do not agree with the measured nightside emission. The discrepancies in the model-data comparisons for WASP-19b might be explained by high-altitude silicate clouds on the nightside and/or high atmospheric metallicity, while the very low 3.6 μm nightside planetary brightness for HAT-P-7b may be indicative of an enhanced global C/O ratio. We compute Bond albedos of 0.38 ± 0.06 and 0 (\\lt 0.08 at 1σ ) for WASP-19b and HAT-P-7b, respectively. In the context of other planets with thermal phase curve measurements, we show that WASP-19b and HAT-P-7b fit the general trend of decreasing day-night heat recirculation with increasing irradiation.

  7. H2 genotypes of G4P[6], G5P[7], and G9[23] porcine rotaviruses show super-short RNA electropherotypes.

    PubMed

    Nagai, Makoto; Shimada, Saya; Fujii, Yoshiki; Moriyama, Hiromitsu; Oba, Mami; Katayama, Yukie; Tsuchiaka, Shinobu; Okazaki, Sachiko; Omatsu, Tsutomu; Furuya, Tetsuya; Koyama, Satoshi; Shirai, Junsuke; Katayama, Kazuhiko; Mizutani, Tetsuya

    2015-04-17

    During group A rotavirus (RVA) surveillance of pig farms in Japan, we detected three RVA strains (G4P[6], G5P[7], and G9P[23] genotypes), which showed super-short RNA patterns by polyacrylamide gel electrophoresis, in samples from a healthy eight-day-old pig and two pigs of seven and eight days old with diarrhea from three farms. Reverse transcription PCR and sequencing revealed that the full-length NSP5 gene of these strains contained 952 or 945 nucleotides, which is consistent with their super-short electropherotypes. Due to a lack of whole genome data on Japanese porcine RVAs, we performed whole genomic analyses of the three strains. The genomic segments of these RVA strains showed typical porcine RVA constellations, except for H2 NSP5 genotype, (G4,5,9-P[6,7,23]-I5-R1-C1-M1-A8-N1-T1-E1-H2 representing VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes). In phylogenetic analyses, these porcine RVA strains clustered with porcine and porcine-like human RVA strains and showed a typical porcine RVA backbone, except for the NSP5 gene; however, intra-genotype reassortment events among porcine and porcine-like human RVA strains were observed. The NSP5 gene segments of these strains were clustered within the H2b genotype with super-short human RVA strains. The H2 genotype has to date only been identified in human and lapine RVA strains. Thus, to our knowledge, this report presents the first case of H2 NSP5 genotype showing a super-short RNA pattern in porcine RVA. These data suggest the possibility of interspecies transmission between pigs and humans and imply that super-short porcine RVA strains possessing H2 genotype are circulating among both asymptomatic and diarrheic porcine populations in Japan. PMID:25724331

  8. Hydrido copper clusters supported by dithiocarbamates: oxidative hydride removal and neutron diffraction analysis of [Cu7(H){S2C(aza-15-crown-5)}6].

    PubMed

    Liao, Ping-Kuei; Fang, Ching-Shiang; Edwards, Alison J; Kahlal, Samia; Saillard, Jean-Yves; Liu, C W

    2012-06-18

    Reactions of Cu(I) salts with Na(S(2)CR) (R = N(n)Pr(2), NEt(2), aza-15-crown-5), and (Bu(4)N)(BH(4)) in an 8:6:1 ratio in CH(3)CN solution at room temperature yield the monocationic hydride-centered octanuclear Cu(I) clusters, [Cu(8)(H){S(2)CR}(6)](PF(6)) (R = N(n)Pr(2), 1(H); NEt(2), 2(H); aza-15-crown-5, 3(H)). Further reactions of [Cu(8)(H){S(2)CR}(6)](PF(6)) with 1 equiv of (Bu(4)N)(BH(4)) produced neutral heptanuclear copper clusters, [Cu(7)(H){S(2)CR}(6)] (R = N(n)Pr(2), 4(H); NEt(2), 5(H); aza-15-crown-5, 6(H)) and clusters 4-6 can also be generated from the reaction of Cu(BF(4))(2), Na(S(2)CR), and (Bu(4)N)(BH(4)) in a 7:6:8 molar ratio in CH(3)CN. Reformation of cationic Cu(I)(8) clusters by adding 1 equiv of Cu(I) salt to the neutral Cu(7) clusters in solution is observed. Intriguingly, the central hydride in [Cu(8)(H){S(2)CN(n)Pr(2)}(6)](PF(6)) can be oxidatively removed as H(2) by Ce(NO(3))(6)(2-) to yield [Cu(II)(S(2)CN(n)Pr(2))(2)] exploiting the redox-tolerant nature of dithiocarbamates. Regeneration of hydride-centered octanuclear copper clusters from the [Cu(II)(S(2)CN(n)Pr(2))(2)] can be achieved by reaction with Cu(I) ions and borohydride. The hydride release and regeneration of Cu(I)(8) was monitored by UV-visible titration experiments. To our knowledge, this is the first time that hydride encapsulated within a copper cluster can be released as H(2) via chemical means. All complexes have been fully characterized by (1)H NMR, FT-IR, UV-vis, and elemental analysis, and molecular structures of 1(H), 2(H), and 6(H) were clearly established by single-crystal X-ray diffraction. Both 1(H) and 2(H) exhibit a tetracapped tetrahedral Cu(8) skeleton, which is inscribed within a S(12) icosahedron constituted by six dialkyl dithiocarbamate ligands in a tetrametallic-tetraconnective (μ(2), μ(2)) bonding mode. The copper framework of 6(H) is a tricapped distorted tetrahedron in which the four-coordinate hydride is demonstrated to occupy the central site by

  9. Are 1,5- and 1,7-dihydrodiimidazo[4,5-b:4‧,5‧-e]pyrazine the main products of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) alkaline hydrolysis? A DFT study of vibrational spectra

    NASA Astrophysics Data System (ADS)

    Kholod, Yana; Okovytyy, Sergiy; Kuramshina, Gulnara; Qasim, Mohammad; Gorb, Leonid; Furey, John; Honea, Patricia; Fredrickson, Herbert; Leszczynski, Jerzy

    2006-08-01

    The fully optimized geometries and force fields of the most stable conformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane and two tautomers 1,5- and 1,7-dihydrodiimidazo[4,5- b:4',5'- e]pyrazine were obtained at the B3LYP level of hybrid density functional theory with the 6-31G(d) basis set. The vibrational frequencies were calculated by scaling of force fields, and the vibrational spectra were interpreted taking into account potential energy distributions. DFT calculations provide good agreement between calculated and experimental vibrational frequencies, obtained for CL-20. The theoretical vibrational spectra of 1,5- and 1,7-dihydrodiimidazo[4,5- b:4',5'- e]pyrazine correspond to the experimental FTIR spectrum obtained for the CL-20 alkaline hydrolysis products.

  10. The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward.

    PubMed

    Khroyan, Taline V; Polgar, Willma E; Cami-Kobeci, Gerta; Husbands, Stephen M; Zaveri, Nurulain T; Toll, Lawrence

    2011-03-01

    Certain behavioral features of buprenorphine, including a bell-shaped curve for antinociception and attenuation of alcohol consumption, are thought to be mediated by activation of nociceptin/orphanin FQ peptide (NOP) receptors, despite moderate affinity and low efficacy at NOP receptors. We hypothesized that ligands with buprenorphine's physical properties, but possessing increased NOP receptor affinity and efficacy, would improve the profile as a drug abuse medication and reduce addiction liability. Using this strategy, we designed several compounds with universally high affinity, i.e., less than 10 nM at μ, δ, κ, and NOP receptors. Among these, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028) has high affinity at all opioid receptors and increased NOP receptor efficacy in vitro in the [³⁵S]GTPγS binding assay, however, while still being a partial agonist. In vivo, BU08028 was evaluated in an acute thermal antinociception assay, for its ability to induce conditioned place preference (CPP), and for its effect on cocaine-induced CPP. BU08028 is a very potent long-lasting analgesic. It produces an increase in locomotor activity and a significant CPP. As a pretreatment to cocaine, BU08028 does not alter cocaine CPP but causes a further increase in cocaine-induced locomotor activity. The analgesic, rewarding, and stimulant effects are probably caused by μ receptor stimulation. It is likely that with BU08028, a partial agonist at both NOP and μ receptors, μ-mediated activity overpowers NOP-mediated effects. Thus, it is possible that a different buprenorphine analog that is a universal high-affinity opioid ligand but with "full agonist" activity at NOP may counteract traditional opioid-mediated effects such as antinociception and reward.

  11. Facile synthesis of 4,5,6a,7-tetrahydrodibenzo[de,g]chromene heterocycles and their transformation to phenanthrene alkaloids

    PubMed Central

    Kapadia, Nirav; Harding, Wayne

    2013-01-01

    Oxa-Pictet-Spengler cyclization and microwave-assisted C-H arylation have been implemented as key steps in the synthesis of new isochroman heterocycles containing a 4,5,6a,7-tetrahydrodibenzo[de,g]chromene motif. These isochromans may be easily transformed to phenanthrene alkaloids via acidic cleavage of the isochroman ring and standard synthetic manipulations thereafter. The route described is attractive in that it provides access to two biologically interesting scaffolds in simple and high yielding synthetic steps. PMID:24187388

  12. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors.

    PubMed

    Asano, Shigehiro; Komiya, Masafumi; Koike, Nobuyuki; Koga, Erina; Nakatani, Shogo; Isobe, Yoshiaki

    2010-11-15

    A novel series of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines containing substituted phenyl sulfonamide are synthesized and evaluated for their inhibitory activity against CaMKII. Substituents on the phenyl group had significant impact on CaMKII inhibition, in particular, the inhibitory activity of 8p was 25-fold higher than that of KN-93, a known CaMKII inhibitor. Michaelis-Menten analysis of a representative compound suggested that the synthesized pyrimidines are calmodulin non-competitive inhibitors. Finally, 8p exhibited more than 100-fold higher selectivity for CaMKII over five types of off-target kinases. PMID:20875738

  13. Serological comparison of antibodies to avian influenza viruses, subtypes H5N2, H6N1, H7N3 and H7N9 between poultry workers and non-poultry workers in Taiwan in 2012.

    PubMed

    Huang, S Y; Yang, J R; Lin, Y J; Yang, C H; Cheng, M C; Liu, M T; Wu, H S; Chang, F Y

    2015-10-01

    In Taiwan, avian influenza virus (AIV) subtypes H5N2, H6N1 and H7N3 have been identified in domestic poultry, and several strains of these subtypes have become endemic in poultry. To evaluate the potential of avian-to-human transmission due to occupational exposure, an exploratory analysis of AIV antibody status in poultry workers was conducted. We enrolled 670 poultry workers, including 335 live poultry vendors (LPVs), 335 poultry farmers (PFs), and 577 non-poultry workers (NPWs). Serum antibody titres against various subtypes of viruses were analysed and compared. The overall seropositivity rates in LPVs and PFs were 2·99% (10/335) and 1·79% (6/335), respectively, against H5N2; and 0·6% (2/335) and 1·19% (4/335), respectively, for H7N3 virus. Of NPWs, 0·35% (2/577) and 0·17% (1/577) were seropositive for H5N2 and H7N3, respectively. Geographical analysis revealed that poultry workers whose workplaces were near locations where H5N2 outbreaks in poultry have been reported face greater risks of being exposed to viruses that result in elevated H5N2 antibody titres. H6N1 antibodies were detected in only one PF, and no H7N9 antibodies were found in the study subjects. Subclinical infections caused by H5N2, H6N1 and H7N3 viruses were thus identified in poultry workers in Taiwan. Occupational exposure is associated with a high risk of AIV infection, and the seroprevalence of particular avian influenza strains in humans reflects the endemic strains in poultry in this region.

  14. (9E)-9-benzylidene-2-methylsulfanyl-5-phenyl-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one: a hydrogen-bonded R2(2)(8) dimer.

    PubMed

    Becerra, Diana; Insuasty, Braulio; Cobo, Justo; Glidewell, Christopher

    2013-12-15

    In the molecule of the title compound, C25H21N3OS, which was prepared by mild oxidation of the corresponding 5,6,7,8,9,10-hexahydro analogue, the fused carbocyclic ring adopts an envelope conformation. Pairs of molecules are linked into cyclic centrosymmetric dimers by pairs of inversion-related N-H···O hydrogen bonds.

  15. Measurement of the ^241Am(n,2n) reaction cross section from 7.6 to 14.5 MeV

    NASA Astrophysics Data System (ADS)

    Tonchev, A.; Angell, C.; Becker, J.; Bond, E.; Dashdorj, D.; Fallin, B.; Fitzpatrick, J.; Howell, C.; Hutcheson, A.; Karwowski, H.; Kelley, J.; Macri, R.; Pedroni, R.; Slemmons, A.; Stoyer, M.; Tornow, W.; Vieira, D.; Wilhelmy, J.; Wu, C.

    2007-10-01

    High-precision measurements of the ^241Am(n,2n)^240Am reaction have been performed with neutron energies from 7.6 to 14.5 MeV. The monoenergetic neutron beams were produced via the ^2H(d,n)^3He reaction using the 10 MV Tandem accelerator at TUNL. The radioactive targets consisted of 1mg highly-enriched ^241Am, sandwiched between three different thin monitor foils. They were irradiated with a neutron flux of 3x10^7 n cm-2s-1. After each irradiation the induced activity in the targets and monitors was measured off-line with 60% HPGe detectors. Our neutron induced cross sections will be compared with recent literature results and statistical model calculations.

  16. 40 CFR 721.10273 - 3′H-Cyclopropa[7,22][5,6]fullerene-C70-D5h(6)-3′-butanoic acid, 3′-phenyl-, methyl ester.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.10273 3′H-Cyclopropa fullerene-C70-D5h(6)-3′-butanoic acid, 3′-phenyl-, methyl ester. (a) Chemical substance and significant new...

  17. Monte Carlo N–Particle Transport Code System Including MCNP6.1, MCNP5-1.60, MCNPX-2.7.0 and Data Libraries.

    SciTech Connect

    GOORLEY, TIM

    2013-07-16

    Version 00 US DOE 10CFR810 Jurisdiction. MCNP6™ is a general-purpose, continuous-energy, generalized-geometry, time-dependent, Monte Carlo radiation-transport code designed to track many particle types over broad ranges of energies. MCNP6 represents the culmination of a multi-year effort to merge the MCNP5™ [X-503] and MCNPX™ [PEL11] codes into a single product comprising all features of both. For those familiar with previous versions of MCNP, you will discover the code has been expanded to handle a multitude of particles and to include model physics options for energies above the cross-section table range, a material burnup feature, and delayed particle production. Expanded and/or new tally, source, and variance-reduction options are available to the user as well as an improved plotting capability. The capability to calculate keff eigenvalues for fissile systems remains a standard feature. Although MCNP6 is simply and accurately described as the merger of MCNP5 and MCNPX capabilities, the result is much more than the sum of these two computer codes. MCNP6 is the result of five years of effort by the MCNP5 and MCNPX code development teams. These groups of people, residing in the Los Alamos National Laboratory's (LANL) X Computational Physics Division, Monte Carlo Codes Group (XCP-3), and Nuclear Engineering and Nonproliferation Division, Systems Design and Analysis Group (NEN-5, formerly D-5), have combined their code development efforts to produce the next evolution of MCNP. While maintenance and bug fixes will continue for MCNP5 v.1.60 and MCNPX v.2.7.0 for upcoming years, new code development capabilities will be developed and released only in MCNP6. In fact, this initial production release of MCNP6 (v. 1.0) contains 16 new features not previously found in either code. These new features include (among others) the abilities to import unstructured mesh geometries from the finite element code Abaqus, to transport photons down to 1.0 eV, to model complete atomic

  18. Monte Carlo N–Particle Transport Code System Including MCNP6.1, MCNP5-1.60, MCNPX-2.7.0 and Data Libraries.

    SciTech Connect

    GOORLEY, TIM

    2013-07-16

    Version 01 US DOE 10CFR810 Jurisdiction. MCNP6™ is a general-purpose, continuous-energy, generalized-geometry, time-dependent, Monte Carlo radiation-transport code designed to track many particle types over broad ranges of energies. MCNP6 represents the culmination of a multi-year effort to merge the MCNP5™ [X-503] and MCNPX™ [PEL11] codes into a single product comprising all features of both. For those familiar with previous versions of MCNP, you will discover the code has been expanded to handle a multitude of particles and to include model physics options for energies above the cross-section table range, a material burnup feature, and delayed particle production. Expanded and/or new tally, source, and variance-reduction options are available to the user as well as an improved plotting capability. The capability to calculate keff eigenvalues for fissile systems remains a standard feature. Although MCNP6 is simply and accurately described as the merger of MCNP5 and MCNPX capabilities, the result is much more than the sum of these two computer codes. MCNP6 is the result of five years of effort by the MCNP5 and MCNPX code development teams. These groups of people, residing in the Los Alamos National Laboratory's (LANL) X Computational Physics Division, Monte Carlo Codes Group (XCP-3), and Nuclear Engineering and Nonproliferation Division, Systems Design and Analysis Group (NEN-5, formerly D-5), have combined their code development efforts to produce the next evolution of MCNP. While maintenance and bug fixes will continue for MCNP5 v.1.60 and MCNPX v.2.7.0 for upcoming years, new code development capabilities will be developed and released only in MCNP6. In fact, this initial production release of MCNP6 (v. 1.0) contains 16 new features not previously found in either code. These new features include (among others) the abilities to import unstructured mesh geometries from the finite element code Abaqus, to transport photons down to 1.0 eV, to model complete atomic

  19. Monte Carlo N–Particle Transport Code System Including MCNP6.1, MCNP5-1.60, MCNPX-2.7.0 and Data Libraries.

    2013-07-16

    Version 00 US DOE 10CFR810 Jurisdiction. MCNP6™ is a general-purpose, continuous-energy, generalized-geometry, time-dependent, Monte Carlo radiation-transport code designed to track many particle types over broad ranges of energies. MCNP6 represents the culmination of a multi-year effort to merge the MCNP5™ [X-503] and MCNPX™ [PEL11] codes into a single product comprising all features of both. For those familiar with previous versions of MCNP, you will discover the code has been expanded to handle a multitude ofmore » particles and to include model physics options for energies above the cross-section table range, a material burnup feature, and delayed particle production. Expanded and/or new tally, source, and variance-reduction options are available to the user as well as an improved plotting capability. The capability to calculate keff eigenvalues for fissile systems remains a standard feature. Although MCNP6 is simply and accurately described as the merger of MCNP5 and MCNPX capabilities, the result is much more than the sum of these two computer codes. MCNP6 is the result of five years of effort by the MCNP5 and MCNPX code development teams. These groups of people, residing in the Los Alamos National Laboratory's (LANL) X Computational Physics Division, Monte Carlo Codes Group (XCP-3), and Nuclear Engineering and Nonproliferation Division, Systems Design and Analysis Group (NEN-5, formerly D-5), have combined their code development efforts to produce the next evolution of MCNP. While maintenance and bug fixes will continue for MCNP5 v.1.60 and MCNPX v.2.7.0 for upcoming years, new code development capabilities will be developed and released only in MCNP6. In fact, this initial production release of MCNP6 (v. 1.0) contains 16 new features not previously found in either code. These new features include (among others) the abilities to import unstructured mesh geometries from the finite element code Abaqus, to transport photons down to 1.0 eV, to model

  20. Monte Carlo N–Particle Transport Code System Including MCNP6.1, MCNP5-1.60, MCNPX-2.7.0 and Data Libraries.

    2013-07-16

    Version 01 US DOE 10CFR810 Jurisdiction. MCNP6™ is a general-purpose, continuous-energy, generalized-geometry, time-dependent, Monte Carlo radiation-transport code designed to track many particle types over broad ranges of energies. MCNP6 represents the culmination of a multi-year effort to merge the MCNP5™ [X-503] and MCNPX™ [PEL11] codes into a single product comprising all features of both. For those familiar with previous versions of MCNP, you will discover the code has been expanded to handle a multitude ofmore » particles and to include model physics options for energies above the cross-section table range, a material burnup feature, and delayed particle production. Expanded and/or new tally, source, and variance-reduction options are available to the user as well as an improved plotting capability. The capability to calculate keff eigenvalues for fissile systems remains a standard feature. Although MCNP6 is simply and accurately described as the merger of MCNP5 and MCNPX capabilities, the result is much more than the sum of these two computer codes. MCNP6 is the result of five years of effort by the MCNP5 and MCNPX code development teams. These groups of people, residing in the Los Alamos National Laboratory's (LANL) X Computational Physics Division, Monte Carlo Codes Group (XCP-3), and Nuclear Engineering and Nonproliferation Division, Systems Design and Analysis Group (NEN-5, formerly D-5), have combined their code development efforts to produce the next evolution of MCNP. While maintenance and bug fixes will continue for MCNP5 v.1.60 and MCNPX v.2.7.0 for upcoming years, new code development capabilities will be developed and released only in MCNP6. In fact, this initial production release of MCNP6 (v. 1.0) contains 16 new features not previously found in either code. These new features include (among others) the abilities to import unstructured mesh geometries from the finite element code Abaqus, to transport photons down to 1.0 eV, to model

  1. TOXIC SUBSTANCES FROM COAL COMBUSTION--A COMPREHENSIVE ASSESSMENT, PHASE II: ELEMENT MODES OF OCCURRENCE FOR THE OHIO 5/6/7, WYODAK AND NORTH DAKOTA COAL SAMPLES

    SciTech Connect

    Allan Kolker; Stanley J. Mroczkowski; Curtis A. Palmer; Kristen O. Dennen; Robert B. Finkelman; John H. Bullock Jr.

    2002-05-30

    This study reports on the second phase (Phase II) of USGS research activities in support of DOE contract DE-AC22-95PC95101 ''Toxic Substances From Coal Combustion--A Comprehensive Assessment'', funded under DOE Interagency Agreement DE-AI22-95PC95145. The purpose of the study was to provide a quantitative and semi-quantitative characterization of the modes of occurrence of trace elements in coal samples investigated under Phase II, including (1) Ohio 5/6/7, an Ohio bituminous coal sample blended from the No.5, No.6, and No.7 beds; (2) North Dakota, a lignite sample from the Falkirk Mine, Underwood, ND, and (3) Wyodak, a sub-bituminous coal sample from the Cordero Mine, Gillette, WY. Samples from these coal beds were selected for their range in rank and commercial applicability. Results of this research provide basic information on the distribution of elements in Phase II coal samples, information needed for development of a commercial predictive model for trace-element behavior during coal combustion.

  2. PIP2-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6

    NASA Astrophysics Data System (ADS)

    Kasimova, Marina A.; Zaydman, Mark A.; Cui, Jianmin; Tarek, Mounir

    2015-01-01

    Among critical aspects of voltage-gated potassium (Kv) channels' functioning is the effective communication between their two composing domains, the voltage sensor (VSD) and the pore. This communication, called coupling, might be transmitted directly through interactions between these domains and, as recently proposed, indirectly through interactions with phosphatidylinositol-4,5-bisphosphate (PIP2), a minor lipid of the inner plasma membrane leaflet. Here, we show how the two components of coupling, mediated by protein-protein or protein-lipid interactions, both contribute in the Kv7.1 functioning. On the one hand, using molecular dynamics simulations, we identified a Kv7.1 PIP2 binding site that involves residues playing a key role in PIP2-dependent coupling. On the other hand, combined theoretical and experimental approaches have shown that the direct interaction between the segments of the VSD (S4-S5) and the pore (S6) is weakened by electrostatic repulsion. Finally, we conclude that due to weakened protein-protein interactions, the PIP2-dependent coupling is especially prominent in Kv7.1.

  3. PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6.

    PubMed

    Kasimova, Marina A; Zaydman, Mark A; Cui, Jianmin; Tarek, Mounir

    2015-01-06

    Among critical aspects of voltage-gated potassium (Kv) channels' functioning is the effective communication between their two composing domains, the voltage sensor (VSD) and the pore. This communication, called coupling, might be transmitted directly through interactions between these domains and, as recently proposed, indirectly through interactions with phosphatidylinositol-4,5-bisphosphate (PIP₂), a minor lipid of the inner plasma membrane leaflet. Here, we show how the two components of coupling, mediated by protein-protein or protein-lipid interactions, both contribute in the Kv7.1 functioning. On the one hand, using molecular dynamics simulations, we identified a Kv7.1 PIP₂ binding site that involves residues playing a key role in PIP₂-dependent coupling. On the other hand, combined theoretical and experimental approaches have shown that the direct interaction between the segments of the VSD (S4-S5) and the pore (S6) is weakened by electrostatic repulsion. Finally, we conclude that due to weakened protein-protein interactions, the PIP2-dependent coupling is especially prominent in Kv7.1.

  4. Luminescence and energy transfer properties of novel Na2.5Y0.5Mg7(PO4)6: R (R = Eu(2+), Tb(3+) and Mn(2+)) phosphors.

    PubMed

    Xu, Yongyan; Li, Xueming; Feng, Wenlin; Li, Wulin; Zhang, Kai

    2016-03-01

    A series of Eu(2+), Mn(2+) and Tb(3+) singly and co-doped Na2.5Y0.5Mg7(PO4)6 phosphors have been prepared by the solid-state reaction method. X-ray diffraction (XRD) patterns, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS) have been used to characterise the crystal structure, morphology and composition of the as-prepared samples. The emission intensities of Mn(2+) and Tb(3+) are enhanced due to an efficient energy transfer from Eu(2+) to Mn(2+) and Tb(3+) in Na2.5Y0.5Mg7(PO4)6. In addition, the energy transfer mechanisms between Mn(2+), Tb(3+) and Eu(2+) have been demonstrated. Similarly, white light emission in the Na2.5Y0.5Mg7(PO4)6 host can be realized by adjusting the co-doped concentration of Eu(2+), Tb(3+) and Mn(2+). The results indicate that the as-prepared phosphors have a great prospect as phosphor-converted materials for light-emitting diodes. PMID:26837518

  5. Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism.

    PubMed

    Boenzi, Sara; Deodato, Federica; Taurisano, Roberta; Goffredo, Bianca Maria; Rizzo, Cristiano; Dionisi-Vici, Carlo

    2016-03-01

    Oxysterols are intermediates of cholesterol metabolism and are generated from cholesterol via either enzymatic or nonenzymatic pathways under oxidative stress conditions. Cholestan-3β,5α,6β-triol (C-triol) and 7-ketocholesterol (7-KC) have been proposed as new biomarkers for the diagnosis of Niemann-Pick type C (NP-C) disease, representing an alternative tool to the invasive and time-consuming method of fibroblast filipin test. To test the efficacy of plasma oxysterol determination for the diagnosis of NP-C, we systematically screened oxysterol levels in patients affected by different inherited disorders related with cholesterol metabolism, which included Niemann-Pick type B (NP-B) disease, lysosomal acid lipase (LAL) deficiency, Smith-Lemli-Opitz syndrome (SLOS), congenital familial hypercholesterolemia (FH), and sitosterolemia (SITO). As expected, NP-C patients showed significant increase of both C-triol and 7-KC. Strong increase of both oxysterols was observed in NP-B and less pronounced in LAL deficiency. In SLOS, only 7-KC was markedly increased, whereas in both FH and in SITO, oxysterol concentrations were normal. Interestingly, in NP-C alone, we observed that plasma oxysterols correlate negatively with patient's age and positively with serum total bilirubin, suggesting the potential relationship between oxysterol levels and hepatic disease status. Our results indicate that oxysterols are reliable and sensitive biomarkers of NP-C.

  6. (4R,7S)-2-Amino-4-(3,4-dimeth­oxy­phen­yl)-5-oxo-7-phenyl-5,6,7,8-tetra­hydro-4H-chromene-3-carbonitrile monohydrate

    PubMed Central

    Sun, Rong; Wu, Dong-Dong; Wang, Ke; Huang, Wei; Ou, Yang-Bing

    2012-01-01

    The title compound, C24H22N2O4·H2O, was obtained by the reaction of 3,4-dimeth­oxy­benzaldehyde, malononitrile and 5-phenyl­cyclo­hexane-1,3-dione. The cyclo­hexyl and pyran rings show half-boat and V-shaped conformations, respectively. The dihedral angle between the phenyl and benzene ring planes is 30.67 (9)°. The organic mol­ecules are packed in a two-dimensional network parallel to the bc plane stabilized by inter­molecular N—H⋯N and N—H⋯O hydrogen bonds. PMID:22347026

  7. Synthesis and X-ray structural studies of the dextro-rotatory enantiomer of methyl α-5(4,5,6,7-tetrahydro(3,2- c)thieno pyridyl) (2-chlorophenyl)-acetate isopropylsulfate

    NASA Astrophysics Data System (ADS)

    Renou, Ludovic; Coste, Servane; Coquerel, Gerard

    2007-02-01

    This study resolves conflicting data on a particular salt of the enantiomer of methyl α-5(4,5,6,7-tetrahydro(3,2- c)thieno pyridyl) (2-chlorophenyl)-acetate (S(+)clopidogrel). The title compound, (C 16H 17ClNO 2S) + (C 3H 7O 4S) -, was obtained and successfully characterized by X-ray diffraction, NMR, TG/DSC/MS. This salt previously reported in the literature as a 2-propanol solvate of the hydrogensulfate salt appears to be actually an isopropylsulfate salt.

  8. 7 CFR 412.5 - Appeals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... with 7 CFR 1.13 and addressed to the Manager, Federal Crop Insurance Corporation, United States... 7 Agriculture 6 2010-01-01 2010-01-01 false Appeals. 412.5 Section 412.5 Agriculture Regulations... AGRICULTURE PUBLIC INFORMATION-FREEDOM OF INFORMATION § 412.5 Appeals. Any person whose request under §...

  9. 7 CFR 412.5 - Appeals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... with 7 CFR 1.13 and addressed to the Manager, Federal Crop Insurance Corporation, United States... 7 Agriculture 6 2011-01-01 2011-01-01 false Appeals. 412.5 Section 412.5 Agriculture Regulations... AGRICULTURE PUBLIC INFORMATION-FREEDOM OF INFORMATION § 412.5 Appeals. Any person whose request under §...

  10. 7 CFR 412.5 - Appeals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... with 7 CFR 1.13 and addressed to the Manager, Federal Crop Insurance Corporation, United States... 7 Agriculture 6 2012-01-01 2012-01-01 false Appeals. 412.5 Section 412.5 Agriculture Regulations... AGRICULTURE PUBLIC INFORMATION-FREEDOM OF INFORMATION § 412.5 Appeals. Any person whose request under §...

  11. Formation and characterization of microstructure of as-cast Mg–6Gd–4Y–xZn–0.5Zr (x = 0.3, 0.5 and 0.7 wt.%) alloys

    SciTech Connect

    Wu, Y.J.; Xu, C.; Zheng, F.Y.; Peng, L.M.; Zhang, Y.; Ding, W.J.

    2013-05-15

    Mg–6Gd–4Y–xZn–0.5Zr (x = 0.3, 0.5 and 0.7 wt.%) alloys were prepared via conventional ingot metallurgy (I/M) in this study. The as-cast microstructures of these alloys were established by X-ray diffraction (XRD) analyses, optical microscope (OM), scanning electron microscope (SEM) and transmission electron microscope (TEM) observations. Lamellar stacking order (SF) and 14H-type long period stacking order (LPSO) structure within α-Mg matrix are formed in the three as-cast alloys. The eutectic secondary phase is (Mg,Zn){sub 24}(Gd,Y){sub 5} for the alloy containing 0.3 wt.% Zn, while, it is (Mg,Zn){sub 3}(Gd,Y) for the alloys containing 0.5 wt.% Zn and 0.7 wt.% Zn. Moreover, X phase-(Mg,Zn){sub 12}(Gd,Y) is formed in the latter two as-cast alloys. - Highlights: • LPSO structure has first been found in as-cast Mg–6Gd–4Y–xZn–0.5Zr. • X-phase exists in as-cast Mg–6Gd–4Y–0.3(0.5)Zn–0.5Zr. • Zn content results in different β-phase in the studied alloys.

  12. Crystal structure of 6,7-dihy­droxy-6,7-di­hydro-3H-imidazo[1,2-a]purin-9(5H)-one

    PubMed Central

    Guo, Wei; Li, Cheng-Xun; Lv, Jie; Wang, Jing

    2016-01-01

    The title purine derivative, C7H7N5O3, is an adduct of guanine with glyoxal. In the mol­ecule, the di­hydro­imidazole ring adopts a twisted conformation on the C—C bond, and the two hydroxyl groups lie on opposite sides of the mean plane of the ring. In the crystal, the mol­ecules are linked by N—H⋯O, O—H⋯N and N—H⋯N hydrogen bonds forming a three-dimensional framework. The crystal packing is reinforced by C—H⋯O hydrogen bonds and by offset π–π stacking of the purine ring systems of inversion related mol­ecules [inter­centroid distance = 3.4839 (12) Å]. PMID:27536400

  13. Thermodynamic stability of the molecules YC2, YC3, YC4, YC5, YC6, YC7, and YC8 by high temperature Knudsen effusion mass spectrometry

    NASA Astrophysics Data System (ADS)

    Pelino, Mario; Haque, R.; Bencivenni, L.; Gingerich, K. A.

    1988-05-01

    The molecules YC2, YC3, YC4, YC5, YC6, YC7, and YC8 have been observed in a Knudsen effusion mass spectrometric investigation of the gas phase above the Y-Ir-Au-graphite system. The enthalpies ΔH○0 of the reactions Y(g)+n C(graph)=YCn(g)(n=2-8) were evaluated by the third law method; the second law method was employed for the gaseous molecules with up to six carbon atoms. The selected values of the reaction enthalpies ΔH○0 were combined with ancillary literature data to yield the atomization enthalpies ΔH○a,0 and the standard enthalpies of formation ΔH○f,298.15 in kJ mol-1 of the gaseous yttrium carbides. The values of ΔH○0 and ΔH○a,0 (in kJ mol-1) are 197±5 and 1225±8 for YC2; 377±10 and 1757±12 for YC3; 361±8 and 2484±10 for YC4; 499±10 and 3057±15 for YC5; 536±15 and 3731±20 for YC6; 684±35 and 4294±35 for YC7, and 693±35 and 4727±35 for YC8. The values of ΔH○f,298.15 (in kJ mol-1) are 623±8, 804±12, 790±10, 924±15, 966±20, 1105±35, and 1124±35 for YCn (n=2-8), respectively.

  14. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Classification challenges. 7.30 Section 7.30... INFORMATION Classified Information § 7.30 Classification challenges. (a) Authorized holders of...

  15. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Classification challenges. 7.30 Section 7.30... INFORMATION Classified Information § 7.30 Classification challenges. (a) Authorized holders of...

  16. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Classification challenges. 7.30 Section 7.30... INFORMATION Classified Information § 7.30 Classification challenges. (a) Authorized holders of...

  17. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Classification challenges. 7.30 Section 7.30... INFORMATION Classified Information § 7.30 Classification challenges. (a) Authorized holders of...

  18. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Classification challenges. 7.30 Section 7.30... INFORMATION Classified Information § 7.30 Classification challenges. (a) Authorized holders of...

  19. We are Family: the Conformations of 1-FLUOROALKANES, C_nH2n+1F (n = 2,3,4,5,6,7,8)

    NASA Astrophysics Data System (ADS)

    Obenchain, Daniel A.; Orellana, W.; Cooke, S. A.

    2016-06-01

    he pure rotational spectra of the n = 5, 6, 7, and 8 members of the 1-fluoroalkane family have been recorded between 7 GHz and 14 GHz using chirped pulse Fourier transform microwave spectroscopy. The spectra have been analyzed and results will be presented and compared with previous work on the n= 2, 3, and 4 members. The lowest energy conformer for all family members has the common feature that the fluorine is in a gauche position relative to the alkyl tail for which all other heavy atom dihedral angles, where appropriate, are 180 degrees. For the n = 3 and higher family members the second lowest energy conformer has all heavy atom dihedral angles equal to 180 degrees. For each family member transitions carried by both low energy conformers were observed in the collected rotational spectra. Quantum chemical calculations were performed and trends in the energy separations between these two common conformers will be presented as a function of chain length. Furthermore, longer chain lengths have been examined using only quantum chemical calculations and results will be presented. M. Hayashi, M. Fujitake, T. Inagusa, S. Miyazaki, J.Mol.Struct., 216, 9-26, 1990 W. Caminati, A. C. Fantoni, F. Manescalchi, F. Scappini, Mol.Phys., 64, 1089 ,1988 L. B. Favero, A. Maris, A. Degli Esposti, P. G. Favero, W. Caminati, G. Pawelke, Chem.Eur.J., 6(16), 3018-3025, 2000

  20. Molecular cloning, characterization and expression analysis of Wnt4, Wnt5, Wnt6, Wnt7, Wnt10 and Wnt16 from Litopenaeus vannamei.

    PubMed

    Zhang, Shuang; Li, Chao-Zheng; Yang, Qi-Hui; Dong, Xiao-Hui; Chi, Shu-Yan; Liu, Hong-Yu; Shi, Li-Li; Tan, Bei-Ping

    2016-07-01

    The Wnt (Wg-type MMTV integration site) signaling represents as the negative regulator of virus-induced innate immune responses. Wnt genes act as ligands to activate the Wnt signaling. To know more about the information of Wnt genes in invertebrates, Litopenaeus vannamei Wnt genes (LvWnts) were identified and characterized. In this study, Six Wnt genes (LvWnt4, LvWnt5, LvWnt6, LvWnt7, LvWnt10 and LvWnt16) were obtained in L. vannamei. The complete cDNAs open reading frames (ORF) of LvWnt4, LvWnt5, LvWnt6, LvWnt7, LvWnt10 and LvWnt16 were 1077 bp, 1107 bp, 1350 bp, 1047 bp, 1509 bp and 1158 bp (GenBank accession no. KU169896, KU169897, KU169898, KU169899, KU169900 and KU169901), encoding 358, 368, 449, 348, 502 and 385 amino acid (aa) residues respectively. All the six members of LvWnts contain a Wnt1 domain, which is considered as an important feature of Wnt gene family. ClustalW analysis with amino acid sequences revealed that the proportion of identity with other species was more than 48% for all the LvWnts except LvWnt10 (36-41%). The phylogenetic relationship analysis illustrated that different subtype of Wnts formed their own separate branches and were placed in branch of invertebrates respectively with strong bootstrap support. The constitutive expressions of LvWnts were confirmed by RT-PCR in all the examined five developmental stages and eleven tissues of L. vannamei with different express patterns. LvWnt4, LvWnt5 and LvWnt10 were expressed highest in nerve while LvWnt6, LvWnt7 and LvWnt16 were expressed highest in intestine, stomach and gill, respectively. In addition, all the LvWnts were regulated by white spot syndrome virus (WSSV) challenges at different levels in hepatopancreas, gill and hemocytes, suggesting that Wnt genes may play a role in the defense against pathogenic virus infection in innate immune of L. vannamei.

  1. Cross-comparison of the IRS-P6 AWiFS sensor with the L5 TM, L7 ETM+, & Terra MODIS sensors

    USGS Publications Warehouse

    Chander, G.; Xiong, X.; Angal, A.; Choi, T.; Malla, R.

    2009-01-01

    As scientists and decision makers increasingly rely on multiple Earth-observing satellites to address urgent global issues, it is imperative that they can rely on the accuracy of Earth-observing data products. This paper focuses on the crosscomparison of the Indian Remote Sensing (IRS-P6) Advanced Wide Field Sensor (AWiFS) with the Landsat 5 (L5) Thematic Mapper (TM), Landsat 7 (L7) Enhanced Thematic Mapper Plus (ETM+), and Terra Moderate Resolution Imaging Spectroradiometer (MODIS) sensors. The cross-comparison was performed using image statistics based on large common areas observed by the sensors within 30 minutes. Because of the limited availability of simultaneous observations between the AWiFS and the Landsat and MODIS sensors, only a few images were analyzed. These initial results are presented. Regression curves and coefficients of determination for the top-of-atmosphere (TOA) trends from these sensors were generated to quantify the uncertainty in these relationships and to provide an assessment of the calibration differences between these sensors. ?? 2009 SPIE.

  2. Molecular variants of human papilloma virus 16 E2, E4, E5, E6 and E7 genes associated with cervical neoplasia in Romanian patients.

    PubMed

    Plesa, Adriana; Anton, Gabriela; Iancu, Iulia V; Diaconu, Carmen C; Huica, Irina; Stanescu, Anca D; Socolov, Demetra; Nistor, Elena; Popa, Elena; Stoian, Mihai; Botezatu, Anca

    2014-12-01

    The aim of this study was to identify and associate the sequence variations of human Papillomavirus 16 (HPV16) genes from women who live in two different areas of Romania and associate them with malignant progression. One hundred twenty-four HPV16-positive cervical isolates were collected, and the E2, E4, E5, E6 and E7 viral genes were sequenced. Two new missense mutations in the E6 gene (C279G and A305C) were found (together or alone, in association with other mutations) in 44 of 124 cases. The most frequently simultaneously mutated genes were E4/E2 hinge, E5 and E6 (p = 0.0004) in squamous cell carcinoma (SCC) samples. Also, for SCC patients, the best-correlated mutation patterns were obtained for E4/E2 hinge-E5 (r = 0.7984; p < 0.0001). No sample was found to have all of the investigated viral genes concurrently mutated. Phylogenetic analysis was performed to characterize the viral variants. Similar results were found for SCC and cervical intraepithelial neoplasia III (CINIII) cases. After all of the target gene sequences were assembled, all patients were found to be infected with viruses of the HPV16- European-German (EG) lineage, and two clusters were identified, the first (55/96 variants) from Moldavia and the second (41/96 variants) from Bucharest. The distinct cluster derived from EG in Moldavia could partially explain the increased frequency of SCC in this area. This study has generated a comprehensive set of sequence variation data on HPV16 circulating in Romania to join the existing data and highlight the important role of HPV16 variants during cervical carcinogenesis. PMID:25143263

  3. Subaru High-z Exploration of Low-luminosity Quasars (SHELLQs). I. Discovery of 15 Quasars and Bright Galaxies at 5.7 z > 6.9

    NASA Astrophysics Data System (ADS)

    Matsuoka, Yoshiki; Onoue, Masafusa; Kashikawa, Nobunari; Iwasawa, Kazushi; Strauss, Michael A.; Nagao, Tohru; Imanishi, Masatoshi; Niida, Mana; Toba, Yoshiki; Akiyama, Masayuki; Asami, Naoko; Bosch, James; Foucaud, Sébastien; Furusawa, Hisanori; Goto, Tomotsugu; Gunn, James E.; Harikane, Yuichi; Ikeda, Hiroyuki; Kawaguchi, Toshihiro; Kikuta, Satoshi; Komiyama, Yutaka; Lupton, Robert H.; Minezaki, Takeo; Miyazaki, Satoshi; Morokuma, Tomoki; Murayama, Hitoshi; Nishizawa, Atsushi J.; Ono, Yoshiaki; Ouchi, Masami; Price, Paul A.; Sameshima, Hiroaki; Silverman, John D.; Sugiyama, Naoshi; Tait, Philip J.; Takada, Masahiro; Takata, Tadafumi; Tanaka, Masayuki; Tang, Ji-Jia; Utsumi, Yousuke

    2016-09-01

    We report the discovery of 15 quasars and bright galaxies at 5.7 < z < 6.9. This is the initial result from the Subaru High-z Exploration of Low-Luminosity Quasars project, which exploits the exquisite multiband imaging data produced by the Subaru Hyper Suprime-Cam (HSC) Strategic Program survey. The candidate selection is performed by combining several photometric approaches including a Bayesian probabilistic algorithm to reject stars and dwarfs. The spectroscopic identification was carried out with the Gran Telescopio Canarias and the Subaru Telescope for the first 80 deg2 of the survey footprint. The success rate of our photometric selection is quite high, approaching 100% at the brighter magnitudes (z AB < 23.5 mag). Our selection also recovered all the known high-z quasars on the HSC images. Among the 15 discovered objects, six are likely quasars, while the other six with interstellar absorption lines and in some cases narrow emission lines are likely bright Lyman-break galaxies. The remaining three objects have weak continua and very strong and narrow Lyα lines, which may be excited by ultraviolet light from both young stars and quasars. These results indicate that we are starting to see the steep rise of the luminosity function of z ≥ 6 galaxies, compared with that of quasars, at magnitudes fainter than M 1450 ˜ ‑22 mag or z AB ˜ 24 mag. Follow-up studies of the discovered objects as well as further survey observations are ongoing.

  4. Subaru High-z Exploration of Low-luminosity Quasars (SHELLQs). I. Discovery of 15 Quasars and Bright Galaxies at 5.7 < z < 6.9

    NASA Astrophysics Data System (ADS)

    Matsuoka, Yoshiki; Onoue, Masafusa; Kashikawa, Nobunari; Iwasawa, Kazushi; Strauss, Michael A.; Nagao, Tohru; Imanishi, Masatoshi; Niida, Mana; Toba, Yoshiki; Akiyama, Masayuki; Asami, Naoko; Bosch, James; Foucaud, Sébastien; Furusawa, Hisanori; Goto, Tomotsugu; Gunn, James E.; Harikane, Yuichi; Ikeda, Hiroyuki; Kawaguchi, Toshihiro; Kikuta, Satoshi; Komiyama, Yutaka; Lupton, Robert H.; Minezaki, Takeo; Miyazaki, Satoshi; Morokuma, Tomoki; Murayama, Hitoshi; Nishizawa, Atsushi J.; Ono, Yoshiaki; Ouchi, Masami; Price, Paul A.; Sameshima, Hiroaki; Silverman, John D.; Sugiyama, Naoshi; Tait, Philip J.; Takada, Masahiro; Takata, Tadafumi; Tanaka, Masayuki; Tang, Ji-Jia; Utsumi, Yousuke

    2016-09-01

    We report the discovery of 15 quasars and bright galaxies at 5.7 < z < 6.9. This is the initial result from the Subaru High-z Exploration of Low-Luminosity Quasars project, which exploits the exquisite multiband imaging data produced by the Subaru Hyper Suprime-Cam (HSC) Strategic Program survey. The candidate selection is performed by combining several photometric approaches including a Bayesian probabilistic algorithm to reject stars and dwarfs. The spectroscopic identification was carried out with the Gran Telescopio Canarias and the Subaru Telescope for the first 80 deg2 of the survey footprint. The success rate of our photometric selection is quite high, approaching 100% at the brighter magnitudes (z AB < 23.5 mag). Our selection also recovered all the known high-z quasars on the HSC images. Among the 15 discovered objects, six are likely quasars, while the other six with interstellar absorption lines and in some cases narrow emission lines are likely bright Lyman-break galaxies. The remaining three objects have weak continua and very strong and narrow Lyα lines, which may be excited by ultraviolet light from both young stars and quasars. These results indicate that we are starting to see the steep rise of the luminosity function of z ≥ 6 galaxies, compared with that of quasars, at magnitudes fainter than M 1450 ˜ -22 mag or z AB ˜ 24 mag. Follow-up studies of the discovered objects as well as further survey observations are ongoing.

  5. Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives.

    PubMed

    Bassin, Jatinder P; Anagani, Bhavani; Benham, Christopher; Goyal, Madhu; Hashemian, Maryam; Gerhard, Ute

    2016-01-01

    A simple synthetic route affording 27%-85% yields of benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring systems from readily available 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline starting materials in toluene and catalysed by p-toluene-sulfonic acid is developed. The ¹H- and (13)C-NMR spectra of the final products were assigned using a variety of one and two-dimensional NMR experiments. The distinction between the two potential isomers of the final products was made on the basis of heteronuclear multiple bond connectivity (HMBC) NMR spectra. PMID:27455232

  6. Jejunal mucosal lactase activity from birth to three weeks in conventionally raised calves fed an electrolyte solution on days 5, 6 and 7 instead of milk.

    PubMed

    St Jean, G D; Schmall, L M; Rings, D M; Hoffsis, G F; Hull, B L

    1991-01-01

    The purpose of this study was to evaluate the effect of withdrawal of lactose from the diet for 72 hours on lactase activity in the jejunal mucosa of conventionally raised calves. The descending portion of the duodenum of six Holstein calves less than 24 hours old was cannulated. The calves were fed milk except on days 5, 6 and 7 when they were given the same volume of an electrolyte solution. Sequential biopsy specimens of the proximal jejunal mucosa were obtained for three weeks and the lactase activity determined. Lactase activity was highest on day 1 and a trend toward decreased lactase activity from birth until three weeks was observed. Mean lactase activity was significantly (p less than 0.05) higher for days 1, and 3 compared to days 9, 13 and 17. The withdrawal of milk and replacement by an electrolyte solution during three days had no significant effect on jejunal mucosal lactase activity in neonatal calves.

  7. Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells.

    PubMed

    Lieb, Klaus; Biersack, Lisa; Waschbisch, Anne; Orlikowski, Sonja; Akundi, Ravi Shankar; Candelario-Jalil, Eduardo; Hüll, Michael; Fiebich, Bernd L

    2005-05-01

    Serotonin [5-hydroxytryptamine (5-HT)] is a widely distributed neurotransmitter which is involved in neuroimmunomodulatory processes. Previously, it has been demonstrated that 5-HT may induce interleukin (IL)-6 expression in primary rat hippocampal astrocytes. The present study was undertaken to investigate the molecular pathways underlying this induction of IL-6 synthesis. As a model system, we used the human astrocytoma cell line U373 MG, which synthesizes IL-6 upon stimulation with various inducers. 5-HT dose- and time-dependently induced IL-6 protein synthesis. We identified several 5-HT receptors to be expressed on U373 MG cells, including the 5-HT1D, 5-HT2A, 5-HT3 and 5-HT7 receptors. In this report, we show that the 5-HT-induced IL-6 release is mediated by the 5-HT7 receptor based on several agonist/antagonists that were used. 5-HT-induced IL-6 synthesis is inhibited by the partially selective 5-HT7 receptor antagonist, pimozide, and the selective antagonist SB269970. Furthermore, IL-6 synthesis was induced by the 5-HT7 receptor agonist carboxamidotryptamin. In addition, we found p38 MAPKs and protein kinase C (PKC) epsilon to be involved in 5-HT-induced IL-6 synthesis as specific inhibitors of these enzymes (SB202190 and RO-31-8425, respectively) blocked 5-HT-induced IL-6 synthesis. Furthermore, 5-HT mediated the phosphorylation of both p38 MAPK as well as the PKC epsilon isoform. The p42/44 MAPKs, however, were not involved in 5-HT-induced IL-6 synthesis. This study shows, for the first time, a central role of 5-HT7 receptor linked to p38 MAPK and PKC epsilon for the induction of cytokine synthesis in astrocytic cells. PMID:15836614

  8. Casscf/ci Calculations for First Row Transition Metal Hydrides - the TIH(4-PHI), VH(5-DELTA), CRH(6-SIGMA-PLUS), MNH(7-SIGMA-PLUS), FEH(4,6-DELTA) and NIH(2-DELTA) States

    NASA Astrophysics Data System (ADS)

    Walch, S. P.; Bauschlicher, C. W., Jr.

    1983-04-01

    Calculations are performed for the predicted ground states of TiH(4-phi), VH(5-delta), CrH(6-sigma-plus), MnH(7-sigma-plus), Fett(4,6-delta) and NiH(2-delta). For FeH both the 6-delta and 4-delta states are studied, since both are likely candidates for the ground state. The ground state symmetries are predicted based on a combination of atomic coupling arguments and coupling of 4s(2)3d(n) and 4s(1)3d(n+1) terms in the molecular system. Electron correlation is included by a CASSCF/CI (SD) treatment. The CASSCF includes near-degeneracy effects, while correlation of the 3d electrons in included at the CI level.

  9. 12 CFR 5.7 - Investigations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) of this section. The OCC publishes the rates, described in 12 CFR 8.6, annually in the “Notice of... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Investigations. 5.7 Section 5.7 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES...

  10. 12 CFR 5.7 - Investigations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) of this section. The OCC publishes the rates, described in 12 CFR 8.6, annually in the “Notice of... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Investigations. 5.7 Section 5.7 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES...

  11. 7 CFR 550.5 - Competition.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Competition. 550.5 Section 550.5 Agriculture... Competition. REE agencies may enter into non-assistance cooperative agreements, as authorized by this part, without regard to any requirements for competition. (7 U.S.C. 3318(e))....

  12. 7 CFR 550.5 - Competition.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Competition. 550.5 Section 550.5 Agriculture... Competition. REE agencies may enter into non-assistance cooperative agreements, as authorized by this part, without regard to any requirements for competition. (7 U.S.C. 3318(e))....

  13. 7 CFR 550.5 - Competition.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Competition. 550.5 Section 550.5 Agriculture... Competition. REE agencies may enter into non-assistance cooperative agreements, as authorized by this part, without regard to any requirements for competition. (7 U.S.C. 3318(e))....

  14. 7 CFR 550.5 - Competition.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Competition. 550.5 Section 550.5 Agriculture... Competition. REE agencies may enter into non-assistance cooperative agreements, as authorized by this part, without regard to any requirements for competition. (7 U.S.C. 3318(e))....

  15. 7 CFR 550.5 - Competition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Competition. 550.5 Section 550.5 Agriculture... Competition. REE agencies may enter into non-assistance cooperative agreements, as authorized by this part, without regard to any requirements for competition. (7 U.S.C. 3318(e))....

  16. Far-field triggering of foreshocks near the nucleation zone of the 5 September 2012 (MW 7.6) Nicoya Peninsula, Costa Rica earthquake

    NASA Astrophysics Data System (ADS)

    Walter, Jacob I.; Meng, Xiaofeng; Peng, Zhigang; Schwartz, Susan Y.; Newman, Andrew V.; Protti, Marino

    2015-12-01

    On 5 September 2012, a moment magnitude (MW) 7.6 earthquake occurred directly beneath the Nicoya Peninsula, an area with dense seismic and geodetic network coverage. The mainshock ruptured a portion of a previously identified locked patch that was recognized due to a decade-long effort to delineate the megathrust seismic and aseismic processes in this area. Here we conduct a comprehensive study of the seismicity prior to this event utilizing a matched-filter analysis that allows us to decrease the magnitude of catalog completeness by 1 unit. We observe a statistically significant increase in seismicity rate below the Nicoya Peninsula following the 27 August 2012 (MW 7.3) El Salvador earthquake (about 450 km to the northwest and 9 days prior to the Nicoya earthquake). Additionally, we identify a cluster of small-magnitude (<2.2) earthquakes preceding the mainshock by about 35 min and within 15 km of its hypocenter. The immediate foreshock sequence occurred in the same area as those earthquakes triggered shortly after the El Salvador event; though it is not clear whether the effect of triggering from the El Salvador event persisted until the foreshock sequence given the uncertainties in seismicity rates from a relatively small number of earthquakes. If megathrust earthquakes at such distances can induce significant increases in seismicity during the days before another larger event, this sequence strengthens the need for real-time seismicity monitoring for large earthquake forecasting.

  17. Fragrance material review on 1-[5(or 6)-methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one.

    PubMed

    Scognamiglio, J; Letizia, C S; Api, A M

    2013-12-01

    A toxicologic and dermatologic review of 1-[5(Or 6)-Methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one when used as a fragrance ingredient is presented. 1-[5(Or 6)-Methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1-[5(Or 6)-Methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, phototoxicity, photoallergy, and genotoxicity, data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al., Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A Toxicologic and Dermatologic Assessment of Alkyl Cyclic Ketones When Used as Fragrance Ingredients. (submitted for publication)). for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances.

  18. Comparison of Two Widely Used Human Papillomavirus Detection and Genotyping Methods, GP5+/6+-Based PCR Followed by Reverse Line Blot Hybridization and Multiplex Type-Specific E7-Based PCR.

    PubMed

    Clifford, Gary M; Vaccarella, Salvatore; Franceschi, Silvia; Tenet, Vanessa; Umulisa, M Chantal; Tshomo, Ugyen; Dondog, Bolormaa; Vorsters, Alex; Tommasino, Massimo; Heideman, Daniëlle A M; Snijders, Peter J F; Gheit, Tarik

    2016-08-01

    GP5+/6+-based PCR followed by reverse line blot hybridization (GP5+/6+RLB) and multiplex type-specific PCR (E7-MPG) are two human papillomavirus (HPV) genotyping methodologies widely applied in epidemiological research. We investigated their relative analytical performance in 4,662 samples derived from five studies in Bhutan, Rwanda, and Mongolia coordinated by the International Agency for Research on Cancer (IARC). A total of 630 samples were positive by E7-MPG only (13.5%), 24 were positive by GP5+/6+RLB only (0.5%), and 1,014 were positive (21.8%) by both methods. Ratios of HPV type-specific positivity of the two tests (E7-MPG:GP5+/6+RLB ratio) were calculated among 1,668 samples that were HPV positive by one or both tests. E7-MPG:GP5+/6+RLB ratios were >1 for all types and highly reproducible across populations and sample types. E7-MPG:GP5+/6+RLB ratios were highest for HPV53 (7.5) and HPV68 (7.1). HPV16 (1.6) and HPV18 (1.7) had lower than average E7-MPG:GP5+/6+RLB ratios. Among E7-MPG positive infections, median mean fluorescence intensity (MFI; a semiquantitative measure of viral load) tended to be higher among samples positive for the same virus type by GP5+/6+RLB than for those negative for the same type by GP5+/6+RLB. Exceptions, however, included HPV53, -59, and -82, for which the chances of being undetected by GP5+/6+RLB appeared to be MFI independent. Furthermore, the probability of detecting an additional type by E7-MPG was higher when another type was already detected by GP5+/6+RLB, suggesting the existence of masking effects due to competition for GP5+/6+ PCR primers. In conclusion, this analysis is not an evaluation of clinical performance but may inform choices for HPV genotyping methods in epidemiological studies, when the relative merits and dangers of sensitivity versus specificity for individual types should be considered, as well as the potential to unmask nonvaccine types following HPV vaccination. PMID:27225411

  19. Protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-α-l-rhamnopyranoside, isolated from Annona squamosa leaves in thyrotoxicosis and in hepatic lipid peroxidation in rats.

    PubMed

    Panda, Sunanda; Kar, Anand

    2015-12-15

    Hitherto unknown protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-α-l-rhamnopyranoside (THDMF-Rha); isolated from Annona squamosa leaves were evaluated in l-thyroxine (l-T4)-induced thyrotoxicosis in rats. Administration of l-T4 at 500μg/kg body weight for 12days increased the levels of serum thyroid hormones, the activity of 5'-monodeiodinase-I (5'DI) and hepatic glucose-6-phosphatase (G-6Pase) as well as lipid peroxidation (LPO); with a parallel decrease in the levels of cellular antioxidants and serum lipids. However, administration of the isolated THDMF-Rha at a pre-standardized dose for 15days ameliorated the l-T4-induced alterations in the levels of thyroid hormones, hepatic LPO, G-6-Pase, 5'DI activity, and cellular levels of antioxidants and improved the status of different serum lipids, suggesting its antithyroidal and antioxidative potential. As compared to standard antithyroid drug, propylthiouracil, THDMF-Rha appeared to be more promising.

  20. Measurement of the Am241(n,2n) reaction cross section from 7.6 MeV to 14.5 MeV

    NASA Astrophysics Data System (ADS)

    Tonchev, A. P.; Angell, C. T.; Boswell, M.; Crowell, A. S.; Fallin, B.; Hammond, S.; Howell, C. R.; Hutcheson, A.; Karwowski, H. J.; Kelley, J. H.; Pedroni, R. S.; Tornow, W.; Becker, J. A.; Dashdorj, D.; Kenneally, J.; Macri, R. A.; Stoyer, M. A.; Wu, C. Y.; Bond, E.; Chadwick, M. B.; Fitzpatrick, J.; Kawano, T.; Rundberg, R. S.; Slemmons, A.; Vieira, D. J.; Wilhelmy, J. B.

    2008-05-01

    The (n,2n) cross section of the radioactive isotope Am241 (T1/2=432.6 y) has been measured in the incident neutron energy range from 7.6 to 14.5 MeV in steps of a few MeV using the activation technique. Monoenergetic neutron beams were produced via the H2(d,n)He3 reaction by bombarding a pressurized deuterium gas cell with an energetic deuteron beam at the TUNL 10-MV Van de Graaff accelerator facility. The induced γ-ray activity of Am240 was measured with high-resolution HPGe detectors. The cross section was determined relative to Al, Ni, and Au neutron activation monitor foils, measured in the same geometry. Good agreement is obtained with previous measurements at around 9 and 14 MeV, whereas for a large discrepancy is observed when our data are compared to those reported by Perdikakis near 11 MeV. Very good agreement is found with the END-B/VII evaluation, whereas the JENDL-3.3 evaluation is in fair agreement with our data.

  1. Quantum chemical, ballistic and explosivity calculations on 2,4,6,8-tetranitro-1,3,5,7-tetraaza cyclooctatetraene: a new high energy molecule.

    PubMed

    Gejji, S P; Talawar, M B; Mukundan, T; Kurian, E M

    2006-06-30

    Ab initio molecular orbital calculations have been carried out on 2,4,6,8-tetranitro-1,3,5,7-tetraazacyclooctatetraene, the tetramer of the series (NO(2)CN)(n) where n=1-4, using the Hartree-Fock theory with the 6-31 G(d) basis set. These calculations yield three conformers for the tetramer with D(4h), C(4h) and C(2) symmetries. The nonplanar conformer with the C(2) symmetry turns out to be 99.0 and 164.4kJmol(-1), respectively, lower in energy than the C(4h) and D(4h) conformers. The electron density topography - the density at the bond critical point - has been used as a measure of the CNO(2) strengths. Based on these bond strengths, heats of formation [obtained from the parametric model 3 (PM3) method] and specific decomposition energies, it may be concluded that (NO(2)CN)(4) is a promising candidate in the class of high energy molecules. Theoretically computed explosive (velocity of detonation, detonation pressure, etc.) and ballistic (characteristic velocity, specific impulse, etc.) parameters support these conclusions.

  2. An anti-sepsis monomer, 2',5,6',7-tetrahydroxyflavanonol (THF), identified from Scutellaria baicalensis Georgi neutralizes lipopolysaccharide in vitro and in vivo.

    PubMed

    Fu, Jianfeng; Cao, Hongwei; Wang, Ning; Zheng, Xinchun; Lu, Yongling; Liu, Xin; Yang, Dong; Li, Bin; Zheng, Jiang; Zhou, Hong

    2008-12-10

    Lipopolysaccharide (LPS) is a known trigger in the pathogenesis of sepsis, lipid A being the toxic component. One of several adjuvant therapeutic approaches for severe sepsis is currently focusing on the neutralization of LPS. In order to obtain the components from traditional Chinese herbs that can neutralize the endotoxin, aqueous extractions of twelve herbs were tested using affinity biosensor technology. From twelve herbs, Scutellaria baicalensis Georgi (Huang Qin) found to possess high lipid A-binding abilities, and was selected in subsequent experiments. After subjected to macroporous adsorptive resins and HPLC, we obtained 2',5,6',7-tetrahydroxyflavanonol (THF) from S. baicalensis Georgi under the direction of neutralization of LPS and reducing proinflammatory cytokines. In vitro, THF directly bound to LPS and neutralized its activity. THF not only down-regulated TNF-alpha mRNA expression but also decreased TNF-alpha and IL-6 release from RAW264.7 cells induced by LPS in a dose-dependent manner. THF-mediated inhibition on proinflammatory cytokine release is probably associated with downregulation of LPS-induced TLR4 mRNA augmentation. In vivo, THF could significantly protect mice against a lethal challenge with heat-killed E. coli 35218 (E. coli 35218) in a dose-dependent manner, and decreased the plasma LPS level in endotoxemia mice. These findings provide compelling evidence that THF may be an important potential drug for sepsis treatment. Considering the inhibitory effects of THF on LPS-induced cytokine release are unlikely due to its nonspecific cellular toxicity, THF should be considered as a safe putative candidate for development as a drug for sepsis treatment. PMID:18755299

  3. Toxicity of the explosives 2,4,6-trinitrotoluene, hexahydro-1,3,5-trinitro-1,3,5-triazine, and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine in sediments to Chironomus tentans and Hyalella azteca: low-dose hormesis and high-dose mortality.

    PubMed

    Steevens, Jeffery A; Duke, B Maurice; Lotufo, Guilherme R; Bridges, Todd S

    2002-07-01

    The toxicity of the explosives 2,4,6-trinitrotoluene (TNT); hexahydro-1,3,5-trinitro-1,3,5-triazine (royal demolition explosive [RDX]); and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (high-melting explosive [HMX]), was evaluated in spiked sediment with two freshwater invertebrates. The midge Chironomus tentans and the amphipod Hyalella azteca demonstrated significant toxic effects after exposure to TNT and its degradation products, 1,3,5-trinitrobenzene (TNB) and 2,4-diamino-6-nitrotoluene (2,4-DANT). Significant reductions in survival of C. tentans exposed to TNT, TNB, and 2,4-DANT were observed at nominal sediment concentrations as low as 200 mg/kg. Hyalella azteca was more sensitive to TNT, TNB, and 2,4-DANT than the midge, where significant reductions in survival were observed at nominal concentrations of 50, 100, and 200 mg/kg, respectively. Survival of the midge and the amphipod was unaffected after exposure to RDX or HMX at the highest concentrations of 1,000 and 400 mg/kg, respectively. Growth of the midge, measured as total weight, was significantly reduced by 2,4-DANT. However, significantly increased growth was observed after exposure to sublethal concentrations of RDX and HMX. Although significant reductions in amphipod survival were observed at high concentrations of TNB, growth was significantly increased at sublethal concentrations. The results of the current investigation suggest that organisms exposed to explosives at contaminated sites may be affected at concentrations less than 25 mg/kg through hormetic growth enhancement and at higher concentrations through increased mortality.

  4. Analysis of the uptake of the fluorescent marker 2',7'-bis-(2-carboxyethyl)-5(and-6)-carboxyfluorescein (BCECF) by hydrogenosomes in Trichomonas vaginalis.

    PubMed

    Scott, D A; Docampo, R; Benchimol, M

    1998-06-01

    The fluorescent dye 2',7'-bis-(2-carboxyethyl)-5(and-6)-carboxyfluorescein (BCECF) has been widely used as an indicator of cytosolic pH. Here we report that BCECF localizes to hydrogenosomes (hydrogen-generating organelles found in several phylogenetically separate groups of anaerobic protists) in Trichomonas vaginalis, where it was observable by fluorescence microscopy. Its cellular location was confirmed by treatment of BCECF-loaded cells with diaminobenzidine and hydrogen peroxide together with UV illumination. This produced an osmiophilic precipitate in the matrix of hydrogenosomes, observable by electron microscopy. Use of a short (7.5 min) loading period, loading on ice, use of concentrations of BCECF (acetoxymethyl ester) down to 10 nM, and inclusion of the anion channel blockers probenicid or sulfinpyrazone, or the K+/H+ ionophore nigericin in the loading buffer all failed to prevent hydrogenosomal accumulation of BCECF. This uptake was best observed when intact cells were loaded with the ester form of BCECF, but could also be seen using free BCECF following either incubation with ruptured cells or electroporation of intact cells. Hydrogenosomal BCECF loading was also obtained with washed cell lysates, without cytoplasm or metabolic substrates. We tested a range of other fluorogenic dyes designed for cytosolic labeling, and found that the calcium indicator fura-2 (acetoxymethyl ester) and the cell viability marker fluorescein diacetate also labeled hydrogenosomes. The results illustrate a novel use for BCECF as a fluorescent marker for hydrogenosomes (the first such marker), but present a warning against the indiscriminate use of fluorogenic ester dyes to measure properties of the cytosol in hydrogenosome-containing organisms - the dyes may also be indicating the properties of the hydrogenosome.

  5. Anti-inflammatory effect of the 5,7,4'-trihydroxy-6-geranylflavanone isolated from the fruit of Artocarpus communis in S100B-induced human monocytes.

    PubMed

    Lin, Jer-An; Fang, Song-Chwan; Wu, Chi-Hao; Huang, Shang-Ming; Yen, Gow-Chin

    2011-01-12

    The fruit of Artocarpus communis Moraceae, a traditional starch crop, is a rich source of phytochemicals, such as flavonoids and their derivatives. The aim of this study was to investigate whether 5,7,4'-trihydroxy-6-geranylflavanone (AC-GF), a geranyl flavonoid derivative isolated from the fruits of A. communis, could decrease the activation of inflammatory mediators induced by S100B (ligand of receptor for advanced glycation end products, RAGE) in THP-1 monocytes. According to the results, low levels of AC-GF (≤2.5 μM) showed a great inhibitory effect on gene expression of RAGE and down-regulated both TNF-α and IL-1β secretion and gene expression (p < 0.05). AC-GF also decreased reactive oxygen species (ROS) production in response to S100B (p < 0.05). Additionally, Western blotting revealed that AC-GF could effectively attenuate RAGE-dependent signaling, including expression of protein kinase C (PKC) and p47phox, phosphorylation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK), and particularly NF-κB activation (p < 0.05). In conclusion, this is the first report that AC-GF possesses great antioxidant and anti-inflammatory properties in vitro. This finding may contribute to increased implication and utilization of the fruit of A. communis Moraceae in functional foods.

  6. ELECTRON-ION RECOMBINATION OF Mg{sup 6+} FORMING Mg{sup 5+} AND OF Mg{sup 7+} FORMING Mg{sup 6+}: LABORATORY MEASUREMENTS AND THEORETICAL CALCULATIONS

    SciTech Connect

    Lestinsky, M.; Hahn, M.; Novotny, O.; Savin, D. W.; Badnell, N. R.; Bernhardt, D.; Mueller, A.; Schippers, S.; Bing, D.; Grieser, M.; Hoffmann, J.; Jordon-Thaden, B.; Krantz, C.; Orlov, D. A.; Repnow, R.; Shornikov, A.; Wolf, A.

    2012-10-10

    We have measured electron-ion recombination for C-like Mg{sup 6+} forming Mg{sup 5+}, and for B-like Mg{sup 7+} forming Mg{sup 6+}. These studies were performed using a merged electron-ion beam arrangement at the TSR heavy ion storage ring located in Heidelberg, Germany. Both primary ions have metastable levels with significant lifetimes. Using a simple cascade model we estimate the population fractions in these metastable levels. For the Mg{sup 6+} results, we find that the majority of the stored ions are in a metastable level, while for Mg{sup 7+} the metastable fraction is insignificant. We present the Mg{sup 6+} merged beams recombination rate coefficient for DR via N = 2 {yields} N' = 2 core electron excitations ({Delta}N = 0 DR) and for Mg{sup 7+} via 2 {yields} 2 and 2 {yields} 3 core excitations. Taking the estimated metastable populations into account, we compare our results to state-of-the-art multiconfiguration Breit-Pauli theoretical calculations. Significant differences are found at low energies where theory is known to be unreliable. Moreover, for both ions we observe a discrepancy between experiment and theory for {Delta}N = 0 DR involving capture into high-n Rydberg levels and where the stabilization is primarily due to a radiative transition of the excited core electron. This is consistent with previous DR experiments on M-shell iron ions which were performed at TSR. The large metastable content of the Mg{sup 6+} ion beam precludes generating a plasma recombination rate coefficient (PRRC). However, this is not an issue for Mg{sup 7+} and we present an experimentally derived Mg{sup 7+} PRRC for plasma temperatures from 400 K to 10{sup 7} K with an estimated uncertainty of less than 27% at a 90% confidence level. We also provide a fit to our experimentally derived PRRC for use in plasma modeling codes.

  7. Structure Revision of (22E)-Ergosta-7,22-diene-3β,5α,6β,9α,14α- pentol from the Spores of the Medicinal Mushroom Ganoderma lucidum.

    PubMed

    Yaoita, Yasunori; Machida, Koichi

    2016-02-01

    Careful reexamination of the published ¹H and ¹³C NMR spectral data of (22E)-ergosta-7,22-diene-3β,5α,6β,9α,14α-pentol (1), isolated from the spores of the medicinal mushroom Ganoderma lucidum, indicates that, in reality, the compound is (22E)-ergosta-7,22-diene-3β,5α,6β,9α,14β-pentol (5). PMID:27032196

  8. Structure Revision of (22E)-Ergosta-7,22-diene-3β,5α,6β,9α,14α- pentol from the Spores of the Medicinal Mushroom Ganoderma lucidum.

    PubMed

    Yaoita, Yasunori; Machida, Koichi

    2016-02-01

    Careful reexamination of the published ¹H and ¹³C NMR spectral data of (22E)-ergosta-7,22-diene-3β,5α,6β,9α,14α-pentol (1), isolated from the spores of the medicinal mushroom Ganoderma lucidum, indicates that, in reality, the compound is (22E)-ergosta-7,22-diene-3β,5α,6β,9α,14β-pentol (5).

  9. 13b,13c-Di-2-pyridyl-5,7,12,13b,13c,14-hexa­hydro-6H,13H-5a,6a,12a,13a-tetra­azabenz[5,6]azuleno[2,1,8-ija]benz[f]azulene-6,13-dione methanol hemisolvate

    PubMed Central

    Li, Lin; Wang, Zhi-Guo; Wang, Yu-Zhou

    2008-01-01

    The title compound, C30H24N6O2·0.5CH3OH, a glycoluril derivative with two pyridine substituents on the convex face of the glycoluril system, is an important inter­mediate for the synthesis of more complex glycoluril derivatives. The compound crystallizes with two independent mol­ecules in the asymmetric unit, one of which exhibits disorder of one benzene ring over two orientations with refined site occupancy factors 0.65 (4):0.35 (4). The crystal structure contains several short C—H⋯O contacts, and the methanol mol­ecule forms an O—H⋯O hydrogen bond to one of the glycoluril mol­ecules. PMID:21200705

  10. The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.

    PubMed

    Rech, Jason C; Bhattacharya, Anindya; Branstetter, Bryan J; Love, Christopher J; Leenaerts, Joseph E; Cooymans, Ludwig P; Eckert, William A; Ao, Hong; Wang, Qi; Chaplan, Sandra R; Wickenden, Alan D; Lebsack, Alec D; Breitenbucher, J Guy

    2016-10-01

    The synthesis, SAR and preclinical characterization of a series of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists is described herein. The lead compounds are potent inhibitors in Ca(2+) flux and whole blood IL-1β P2X7 release assays at both human and mouse isoforms. Compound 1e showed a robust reduction of IL-1β release in a mouse ex vivo model with a 50mg/kg oral dose. Evaluation of compound 1e in the mouse SNI tactile allodynia, carrageenan-induced paw edema or CIA models resulted in no analgesic or anti-inflammatory effects. PMID:27595421

  11. 7 CFR 761.6 - Appeals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... PROGRAMS GENERAL PROGRAM ADMINISTRATION General Provisions § 761.6 Appeals. Except as provided in 7 CFR part 762, appeal of an adverse decision made by the Agency will be handled in accordance with 7 CFR... 7 Agriculture 7 2011-01-01 2011-01-01 false Appeals. 761.6 Section 761.6 Agriculture...

  12. 7 CFR 613.5 - PMCs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false PMCs. 613.5 Section 613.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE CONSERVATION OPERATIONS PLANT MATERIALS CENTERS § 613.5 PMCs. (a) The Norman A. Berg National...

  13. 7 CFR 600.5 - Area offices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Area offices. 600.5 Section 600.5 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.5 Area offices. Each area office is under the direction and supervision of an area conservationist or assistant State conservationist for field operations who is...

  14. 7 CFR 600.5 - Area offices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Area offices. 600.5 Section 600.5 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.5 Area offices. Each area office is under the direction and supervision of an area conservationist or assistant State conservationist for field operations who is...

  15. 7 CFR 600.5 - Area offices.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Area offices. 600.5 Section 600.5 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.5 Area offices. Each area office is under the direction and supervision of an area conservationist or assistant State conservationist for field operations who is...

  16. 7 CFR 503.5 - Nuisances.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Nuisances. 503.5 Section 503.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.5 Nuisances. The use of loud, abusive or...

  17. 7 CFR 503.5 - Nuisances.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Nuisances. 503.5 Section 503.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.5 Nuisances. The use of loud, abusive or...

  18. 7 CFR 503.5 - Nuisances.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Nuisances. 503.5 Section 503.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.5 Nuisances. The use of loud, abusive or...

  19. 7 CFR 503.5 - Nuisances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Nuisances. 503.5 Section 503.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.5 Nuisances. The use of loud, abusive or...

  20. 7 CFR 503.5 - Nuisances.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Nuisances. 503.5 Section 503.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.5 Nuisances. The use of loud, abusive or...

  1. 7 CFR 501.5 - Nuisances.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Nuisances. 501.5 Section 501.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.5 Nuisances. The use of...

  2. 7 CFR 501.5 - Nuisances.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Nuisances. 501.5 Section 501.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.5 Nuisances. The use of...

  3. 7 CFR 501.5 - Nuisances.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Nuisances. 501.5 Section 501.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.5 Nuisances. The use of...

  4. 7 CFR 501.5 - Nuisances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Nuisances. 501.5 Section 501.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.5 Nuisances. The use of...

  5. 7 CFR 501.5 - Nuisances.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Nuisances. 501.5 Section 501.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.5 Nuisances. The use of...

  6. 7 CFR 625.5 - Application procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Application procedures. 625.5 Section 625.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.5 Application procedures....

  7. 7 CFR 623.5 - Ineligible land.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Ineligible land. 623.5 Section 623.5 Agriculture... AGRICULTURE WATER RESOURCES EMERGENCY WETLANDS RESERVE PROGRAM § 623.5 Ineligible land. Notwithstanding any... conditions; (d) Land located between the pre-flood mainstem levees and the river; or (e) Land that...

  8. 7 CFR 502.5 - Nuisances.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Nuisances. 502.5 Section 502.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.5 Nuisances....

  9. 7 CFR 502.5 - Nuisances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Nuisances. 502.5 Section 502.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.5 Nuisances....

  10. 7 CFR 502.5 - Nuisances.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Nuisances. 502.5 Section 502.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.5 Nuisances....

  11. 7 CFR 502.5 - Nuisances.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Nuisances. 502.5 Section 502.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.5 Nuisances....

  12. 7 CFR 502.5 - Nuisances.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Nuisances. 502.5 Section 502.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.5 Nuisances....

  13. Formation of a Vitamin C Conjugate of Acrolein and its Paraoxonase-mediated Conversion into 5,6,7,8-Tetrahydroxy-4-oxooctanal

    PubMed Central

    Kesinger, Nicholas G.; Langsdorf, Brandi L.; Yokochi, Alexandre F.; Miranda, Cristobal L.; Stevens, Jan F.

    2010-01-01

    Vitamin C (ascorbic acid) has been reported to participate in Michael addition reactions in vitro to form vitamin C conjugates with α,β-unsaturated aldehydes, such as acrolein. This study shows evidence for the formation and metabolism of the vitamin C conjugate of acrolein (AscACR) in cultured human monocytic THP-1 cells exposed to acrolein diacetate. By using 18O and 13C labeling in combination with liquid chromatography–tandem mass spectrometry, AscACR was shown to undergo hydrolytic conversion of the ascorbyl lactone into an intermediate carboxylic acid. Subsequent decarboxylation of the carboxylic acid yielded 5,6,7,8-tetrahydroxy-4-oxooctanal (THO). When THP-1 cells were pretreated with ascorbic acid (1 mM, 18 hours) and then exposed to acrolein diacetate, THO was detected as its pentafluorobenzyl oxime derivative in the cell lysates and medium. Treatment of THP-1 cells with both ascorbic acid and acrolein diacetate was required for THO formation. The formation of THO from AscACR was facilitated by the lactonase enzymes, human recombinant paraoxonases 1 and 2. THP-1 cells exhibited PON activity which explains the catalytic conversion of AscACR into THO in these cells. THO was formed in addition to metabolites of the glutathione conjugate of acrolein, indicating that THO formation contributes to the elimination of acrolein in a cellular environment. PMID:20353174

  14. Fragrance material review on 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE).

    PubMed

    Scognamiglio, J; Letizia, C S; Politano, V T; Api, A M

    2013-12-01

    A toxicologic and dermatologic review of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE) when used as a fragrance ingredient is presented. OTNE is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for OTNE were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, elicitation, phototoxicity, photoallergy, toxicokinetics, repeated dose, reproductive toxicity, and genotoxicity data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (2013) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances.

  15. Gas-jet and tangent-slot film cooling tests of a 12.5 deg cone at Mach number of 6.7

    NASA Technical Reports Server (NTRS)

    Nowak, Robert J.

    1988-01-01

    Tests were conducted in the Langley 8-Foot High Temperature Tunnel to determine the aerothermal effects of gaseous nitrogen-coolant ejection on a 3-ft base-diameter, 12.5 degree half-angle cone. Free-stream Mach number, total temperature, and unit Reynolds number per foot were 6.7, 3300 deg R, and 1.4 million, respectively. Two coolant ejection noses were tested, an ogive frustum with a forward-facing 0.8-in radius gas-jet tip, and a 3-in radius hemisphere with a 0.243-in high rearward-facing tangent slot. Data include surface pressures and heating rates, shock shapes, and shock-layer profiles; results are compared with no-cooling data obtained with 1-in and 3-in radius solid noses. Surface pressures were reduced with gas-jet ejection but were affected little by tangent-slot ejection. For both gas-jet and tangent-slot ejection, high coolant flow rates reduced heating even far downstream from the region of ejection; however, low coolant rates caused transition to turbulence and increased heating. Shock-layer profiles of pitot pressure, Mach number, and total temperature were reduced for both gas-jet and tangent-slot ejection. Insight into the gas-jet heat-flux mechanisms was obtained by using shock-layer rake data and established, no-cooling, heat-transfer equations.

  16. Near-regional CMT and multiple-point source solution of the September 5, 2012, Nicoya, Costa Rica Mw 7.6 (GCMT) earthquake

    NASA Astrophysics Data System (ADS)

    Quintero, Ronnie; Zahradník, Jiri; Sokos, Efthimios

    2014-11-01

    We use acceleration data from the Observatorio Vulcanologico y Sismologico, Universidad Nacional de Costa Rica (OVSICORI-UNA) and Laboratorio de Ingenieria Sismica, Universidad de Costa Rica (LIS-UCR) seismic network for the relocation and moment-tensor solution of the September 5, 2012, 14:42:03.35 UTC, Nicoya, Costa Rica earthquake (Mw 7.6 GCMT). Using different relocation methods we found a stable earthquake hypocenter, near the original OVSICORI-UNA location in the Nicoya Peninsula, NW Costa Rica at Lat 9.6943°N, Lon 85.5689°W, depth 15.3 km, associated with the subduction of the Cocos plate under Caribbean plate. Acceleration records at OVSICORI-UNA and LIS-UCR stations (94-171 km), at 0.03 < f < 0.06 Hz were used in the waveform inversion for a single-point centroid moment tensor (CMT). Using spatial grid search the centroid position was found at the depth of 30 km, situated at Lat 10.0559°N, Lon 85.4778°W, i.e. of about 41 km NNE from the epicenter. The centroid time is 14:42:18.89 UTC, i.e. 15.54 s later relative to the location-based origin time. The nodal plane (strike 318°, dip 27° and rake 115°) is the fault plane that agrees with the geometry of the subducted slab at Nicoya, NNW Costa Rica. Increasing the maximum studied frequency from 0.06 to 0.15 Hz, the multiple point source inversion model leads to two subevents. The first one was located near the centroid and the second subevent was situated 20 km along strike and 10 km down dip from the first subevent and 6 s later. The uncertainty of the source model was carefully examined using complementary inversion methods, viz the iterative deconvolution and non-negative least squares.

  17. 7 CFR 7.6 - Determination of elective areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Determination of elective areas. 7.6 Section 7.6 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF AGRICULTURAL STABILIZATION AND CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.6 Determination of elective areas. (a)...

  18. Second order phase transition temperature of single crystals of Gd5Si1.3Ge2.7 and Gd5Si1.4Ge2.6

    DOE PAGES

    Hadimani, R. L.; Melikhov, Y.; Schlagel, D. L.; Lograsso, T. A.; Dennis, K. W.; McCallum, R. W.; Jiles, D. C.

    2015-01-30

    Gd5(SixGe1–x)4 has mixed phases in the composition range 0.32 < x < 0.41, which have not been widely studied. In this paper, we have synthesized and indexed single crystal samples of Gd5Si1.3Ge2.7 and Gd5Si1.4Ge2.6. In this study, we have investigated the first order and second order phase transition temperatures of these samples using magnetic moment vs. temperature and magnetic moment vs. magnetic field at different temperatures. We have used a modified Arrott plot technique that was developed and reported by us previously to determine the “hidden” second order phase transition temperature of the orthorhombic II phase.

  19. Comparison of Values in 5th, 6th, 7th and 8th Grade Primary Education Music Class Students'? Workbooks According to Rokeach?s and Akbas's Value Classifications

    ERIC Educational Resources Information Center

    Çakirer, H. Serdar

    2014-01-01

    The aim of the present study is to compare the values in the songs of 5th, 6th, 7th and 8th grade primary education music classes students? workbooks according to the value categorizations proposed by Rockeach and Akbas and which values among the categories mentioned are taught to the students in the 5th, 6th, 7th and 8th grade primary education…

  20. Induction of nitric oxide production by the cytostatic macrolide apicularen A [2,4-heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 dihydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)] and possible role of nitric oxide in apicularen A-induced apoptosis in RAW 264.7 cells.

    PubMed

    Hong, JangJa; Yokomakura, Aya; Nakano, Yasuhiro; Ban, Hyun Seung; Ishihara, Kenji; Ahn, Jong-Woong; Zee, OkPyo; Ohuchi, Kazuo

    2005-03-01

    We previously reported that apicularen A [2,4-heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 dihydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)], a highly cytostatic macrolide isolated from the myxobacterial genus Chondromyces, induces apoptosis in the mouse leukemic monocyte cell line RAW 264.7. To analyze the action mechanism of apicularen A for the induction of apoptosis, effects of apicularen A on nitric oxide (NO) production in RAW 264.7 cells were examined. It was demonstrated that apicularen A at 10 and 100 nM induced nitrite production, whereas apicularen B [2,4-heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-7-[[2-(acetylamino)-2-deoxy-beta-d-glucopyranosyl]oxy]-3,4,5,6,7,8,9,10-octahydro-14-hydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)], an N-acetyl-glucosamine glycoside of apicularen A, had no effect at 100 nM. The apicularen A-induced nitrite production was accompanied by an increase in the level of inducible nitric-oxide synthase (iNOS) and its mRNA and was suppressed by the NOS inhibitor N(G)-monomethyl-l-arginine acetate (l-NMMA). In addition, apicularen A activated nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) and decreased the level of IkappaB-alpha and increased that of phosphorylated c-Jun N-terminal kinase (JNK). Furthermore, the apicularen A-induced nitrite production was suppressed by the NF-kappaB inhibitor Bay 11-7082 [(E)-3-(4-methylphenylsulfonyl)-2-propenenitrile] and the JNK inhibitor SP600125 [anthra[1,9-cd]pyrazol-6(2H)-one]. These findings suggested that apicularen A activates NF-kappaB and AP-1, thus triggering the expression of iNOS mRNA and iNOS protein and induces NO production. Finally, apicularen A decreased cell growth and survival and cell viability and disrupted the mitochondrial membrane potential. The addition of l-NMMA partially recovered the apicularen A-induced decrease in cell growth and survival and cell

  1. Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime.

    PubMed

    Amici, Raffaella; Bigogno, Chiara; Boggio, Roberto; Colombo, Andrea; Courtney, Stephen M; Dal Zuffo, Roberto; Dondio, Giulio; Fusar, Fulvia; Gagliardi, Stefania; Minucci, Saverio; Molteni, Marco; Montalbetti, Christian A G N; Mortoni, Annalisa; Varasi, Mario; Vultaggio, Stefania; Mercurio, Ciro

    2014-07-01

    Heat-shock protein 90 (Hsp90) is a molecular chaperone involved in the stabilization of key oncogenic signaling proteins, and therefore, inhibition of Hsp90 represents a new strategy in cancer therapy. 2-Amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime is a racemic Hsp90 inhibitor that targets the N-terminal adenosine triphosphatase site. We developed a method to resolve the enantiomers and evaluated their inhibitory activity on Hsp90 and the consequent antitumor effects. The (S) stereoisomer emerged as a potent Hsp90 inhibitor in biochemical and cellular assays. In addition, this enantiomer exhibited high oral bioavailability in mice and excellent antitumor activity in two different human cancer xenograft models.

  2. Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies.

    PubMed

    Deprèle, Sylvine; Kashemirov, Boris A; Hogan, James M; Ebetino, Frank H; Barnett, Bobby L; Evdokimov, Artem; McKenna, Charles E

    2008-05-01

    The complex formed from crystallization of human farnesyl pyrophosphate synthase (hFPPS) from a solution of racemic [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501, 8), a chiral analog of the anti-osteoporotic drug risedronate, contained the R enantiomer in the enzyme active site. This enantiospecificity was assessed by computer modeling of inhibitor-active site interactions using Autodock 3, which was also evaluated for predictive ability in calculations of the known configurations of risedronate, zoledronate, and minodronate complexed in the active site of hFPPS. In comparison with these structures, the 8 complex exhibited certain differences, including the presence of only one Mg(2+), which could contribute to its 100-fold higher IC(50). An improved synthesis of 8 is described, which decreases the number of steps from 12 to 8 and increases the overall yield by 17-fold.

  3. [5-(2-Fur­yl)-6-nitro-1,2,3,5,6,7-hexa­hydro­imidazo[1,2-a]pyridin-8-yl](phen­yl)methanone

    PubMed Central

    Yaqub, Muhammad; Shafiq, Zahid; Qureshi, Ashfaq M.; Najam-ul-Haq, Muhammad

    2009-01-01

    In the title compound, C18H17N3O4, the furyl and phenyl rings are inclined at almost right angles [85.77 (7) and 63.25 (7)°, respectively] to the central imidazo[1,2-a]pyridinyl unit. The structure displays both inter- and intra­molecular N—H⋯O hydrogen bonding. PMID:21577676

  4. Measurement of elliptic flow of light nuclei at √{sN N}=200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV at the BNL Relativistic Heavy Ion Collider

    NASA Astrophysics Data System (ADS)

    Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alekseev, I.; Aparin, A.; Arkhipkin, D.; Aschenauer, E. C.; Attri, A.; Averichev, G. S.; Bai, X.; Bairathi, V.; Bellwied, R.; Bhasin, A.; Bhati, A. K.; Bhattarai, P.; Bielcik, J.; Bielcikova, J.; Bland, L. C.; Bordyuzhin, I. G.; Bouchet, J.; Brandenburg, J. D.; Brandin, A. V.; Bunzarov, I.; Butterworth, J.; Caines, H.; Calderón de la Barca Sánchez, M.; Campbell, J. M.; Cebra, D.; Chakaberia, I.; Chaloupka, P.; Chang, Z.; Chatterjee, A.; Chattopadhyay, S.; Chen, J. H.; Chen, X.; Cheng, J.; Cherney, M.; Christie, W.; Contin, G.; Crawford, H. J.; Das, S.; De Silva, L. C.; Debbe, R. R.; Dedovich, T. G.; Deng, J.; Derevschikov, A. A.; di Ruzza, B.; Didenko, L.; Dilks, C.; Dong, X.; Drachenberg, J. L.; Draper, J. E.; Du, C. M.; Dunkelberger, L. E.; Dunlop, J. C.; Efimov, L. G.; Engelage, J.; Eppley, G.; Esha, R.; Evdokimov, O.; Eyser, O.; Fatemi, R.; Fazio, S.; Federic, P.; Fedorisin, J.; Feng, Z.; Filip, P.; Fisyak, Y.; Flores, C. E.; Fulek, L.; Gagliardi, C. A.; Garand, D.; Geurts, F.; Gibson, A.; Girard, M.; Greiner, L.; Grosnick, D.; Gunarathne, D. S.; Guo, Y.; Gupta, S.; Gupta, A.; Guryn, W.; Hamad, A. I.; Hamed, A.; Haque, R.; Harris, J. W.; He, L.; Heppelmann, S.; Heppelmann, S.; Hirsch, A.; Hoffmann, G. W.; Horvat, S.; Huang, T.; Huang, X.; Huang, B.; Huang, H. Z.; Huck, P.; Humanic, T. J.; Igo, G.; Jacobs, W. W.; Jang, H.; Jentsch, A.; Jia, J.; Jiang, K.; Judd, E. G.; Kabana, S.; Kalinkin, D.; Kang, K.; Kauder, K.; Ke, H. W.; Keane, D.; Kechechyan, A.; Khan, Z. H.; Kikoła, D. P.; Kisel, I.; Kisiel, A.; Kochenda, L.; Koetke, D. D.; Kosarzewski, L. K.; Kraishan, A. F.; Kravtsov, P.; Krueger, K.; Kumar, L.; Lamont, M. A. C.; Landgraf, J. M.; Landry, K. D.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lee, J. H.; Li, X.; Li, C.; Li, X.; Li, Y.; Li, W.; Lin, T.; Lisa, M. A.; Liu, F.; Ljubicic, T.; Llope, W. J.; Lomnitz, M.; Longacre, R. S.; Luo, X.; Ma, R.; Ma, G. L.; Ma, Y. G.; Ma, L.; Magdy, N.; Majka, R.; Manion, A.; Margetis, S.; Markert, C.; Matis, H. S.; McDonald, D.; McKinzie, S.; Meehan, K.; Mei, J. C.; Minaev, N. G.; Mioduszewski, S.; Mishra, D.; Mohanty, B.; Mondal, M. M.; Morozov, D. A.; Mustafa, M. K.; Nandi, B. K.; Nasim, Md.; Nayak, T. K.; Nigmatkulov, G.; Niida, T.; Nogach, L. V.; Noh, S. Y.; Novak, J.; Nurushev, S. B.; Odyniec, G.; Ogawa, A.; Oh, K.; Okorokov, V. A.; Olvitt, D.; Page, B. S.; Pak, R.; Pan, Y. X.; Pandit, Y.; Panebratsev, Y.; Pawlik, B.; Pei, H.; Perkins, C.; Pile, P.; Pluta, J.; Poniatowska, K.; Porter, J.; Posik, M.; Poskanzer, A. M.; Pruthi, N. K.; Putschke, J.; Qiu, H.; Quintero, A.; Ramachandran, S.; Raniwala, R.; Raniwala, S.; Ray, R. L.; Ritter, H. G.; Roberts, J. B.; Rogachevskiy, O. V.; Romero, J. L.; Ruan, L.; Rusnak, J.; Rusnakova, O.; Sahoo, N. R.; Sahu, P. K.; Sakrejda, I.; Salur, S.; Sandweiss, J.; Sarkar, A.; Schambach, J.; Scharenberg, R. P.; Schmah, A. M.; Schmidke, W. B.; Schmitz, N.; Seger, J.; Seyboth, P.; Shah, N.; Shahaliev, E.; Shanmuganathan, P. V.; Shao, M.; Sharma, M. K.; Sharma, B.; Shen, W. Q.; Shi, Z.; Shi, S. S.; Shou, Q. Y.; Sichtermann, E. P.; Sikora, R.; Simko, M.; Singha, S.; Skoby, M. J.; Smirnov, N.; Smirnov, D.; Solyst, W.; Song, L.; Sorensen, P.; Spinka, H. M.; Srivastava, B.; Stanislaus, T. D. S.; Stepanov, M.; Stock, R.; Strikhanov, M.; Stringfellow, B.; Sumbera, M.; Summa, B.; Sun, X. M.; Sun, Z.; Sun, Y.; Surrow, B.; Svirida, D. N.; Tang, Z.; Tang, A. H.; Tarnowsky, T.; Tawfik, A.; Thäder, J.; Thomas, J. H.; Timmins, A. R.; Tlusty, D.; Todoroki, T.; Tokarev, M.; Trentalange, S.; Tribble, R. E.; Tribedy, P.; Tripathy, S. K.; Tsai, O. D.; Ullrich, T.; Underwood, D. G.; Upsal, I.; Van Buren, G.; van Nieuwenhuizen, G.; Vandenbroucke, M.; Varma, R.; Vasiliev, A. N.; Vertesi, R.; Videbæk, F.; Vokal, S.; Voloshin, S. A.; Vossen, A.; Wang, Y.; Wang, G.; Wang, J. S.; Wang, H.; Wang, Y.; Wang, F.; Webb, G.; Webb, J. C.; Wen, L.; Westfall, G. D.; Wieman, H.; Wissink, S. W.; Witt, R.; Wu, Y.; Xiao, Z. G.; Xie, W.; Xie, G.; Xin, K.; Xu, H.; Xu, Z.; Xu, J.; Xu, Y. F.; Xu, Q. H.; Xu, N.; Yang, Y.; Yang, S.; Yang, C.; Yang, Y.; Yang, Y.; Yang, Q.; Ye, Z.; Ye, Z.; Yepes, P.; Yi, L.; Yip, K.; Yoo, I.-K.; Yu, N.; Zbroszczyk, H.; Zha, W.; Zhang, J.; Zhang, Y.; Zhang, X. P.; Zhang, Z.; Zhang, J. B.; Zhang, S.; Zhang, S.; Zhang, J.; Zhao, J.; Zhong, C.; Zhou, L.; Zhu, X.; Zoulkarneeva, Y.; Zyzak, M.; STAR Collaboration

    2016-09-01

    We present measurements of second-order azimuthal anisotropy (v2) at midrapidity (|y |<1.0 ) for light nuclei d ,t ,3He (for √{sN N}=200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV) and antinuclei d ¯ (√{sN N}=200 , 62.4, 39, 27, and 19.6 GeV) and ¯3He (√{sN N}=200 GeV) in the STAR (Solenoidal Tracker at RHIC) experiment. The v2 for these light nuclei produced in heavy-ion collisions is compared with those for p and p ¯. We observe mass ordering in nuclei v2(pT) at low transverse momenta (pT<2.0 GeV/c ). We also find a centrality dependence of v2 for d and d ¯. The magnitude of v2 for t and 3He agree within statistical errors. Light-nuclei v2 are compared with predictions from a blast-wave model. Atomic mass number (A ) scaling of light-nuclei v2(pT) seems to hold for pT/A <1.5 GeV /c . Results on light-nuclei v2 from a transport-plus-coalescence model are consistent with the experimental measurements.

  5. 29 CFR 6.7 - Appearances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Appearances. 6.7 Section 6.7 Labor Office of the Secretary of Labor RULES OF PRACTICE FOR ADMINISTRATIVE PROCEEDINGS ENFORCING LABOR STANDARDS IN FEDERAL AND FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS General § 6.7 Appearances....

  6. A facile environment-friendly one-pot two-step regioselective synthetic strategy for 3,7-diarylpyrazolo[1,5-a]pyrimidines related to zaleplon and 3,6-diarylpyrazolo[1,5-a]pyrimidine-7-amines assisted by KHSO[Formula: see text] in aqueous media.

    PubMed

    Devi, Asem Satyapati; Kaping, Shunan; Vishwakarma, Jai Narain

    2015-11-01

    3-Aminopyrazoles required for the synthesis of pyrazolo[1,5-a]pyrimidines were obtained by the reaction of enaminonitriles with hydrazine hydrate. The resulting aminopyrazoles are reacted with formylated acetophenones under reflux at [Formula: see text] assisted by KHSO[Formula: see text] in aqueous media to form regioselectively 3,7-diarylpyrazolo[1,5-a]pyrimidines and 3,6-diarylpyrazolo[1,5-a]pyrimidine-7-amines. X-ray crystallography of selected compounds 5b and 7i further confirmed the regioselective formation of these products.

  7. Synthesis and antiviral evalution of some novel pyrazoles and pyrazolo[3,4-d]pyridazines bearing 5,6,7,8-tetrahydronaphthalene.

    PubMed

    Hamdy, Nehal A; El-Senousy, Waled M

    2013-01-01

    The enaminone 2 was reacted with hydrazonyl halides 3a-d to afford the corresponding pyrazole derivatives (6a-d) which reacted with hydrazine hydrate to afford the new pyrazolo[3,4-d]pyridazine derivatives 7a-d, respectively. In addition, compound 2 was reacted with some primary aromatic amines to afford the corresponding secondary enaminones 10a-c and reacted with sulfapyridine or sulfapyrimidine to afford the corresponding sulfonamide derivatives 12a and 12b. Evaluation of these new compounds against rotavirus Wa strain and adenovirus type 7 showed promising antiviral activity.

  8. 7 CFR 761.6 - Appeals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... provided in 7 CFR part 762, appeal of an adverse decision made by the Agency will be handled in accordance with 7 CFR parts 11 and 780. ... 7 Agriculture 7 2012-01-01 2012-01-01 false Appeals. 761.6 Section 761.6 Agriculture...

  9. Measurement of pion elliptic flow with BBC event planes in Au +Au collisions at √sNN = 7.7, 11.5 and 19.6 GeV

    NASA Astrophysics Data System (ADS)

    Chisman, Olivia; STAR Collaboration

    2014-09-01

    The quark gluon plasma (QGP) formed in high-energy heavy-ion collisions at RHIC top energies is a strongly interacting medium. Elliptic flow (v2) , which is the second-order Fourier coefficient of the azimuthal distribution of the produced particles with respect to the reaction plane, has been extensively used to study this medium's properties. Previous STAR data showed a difference in v2 of π+ and π- that becomes more pronounced at lower collision energies such as √sNN = 7.7 GeV. In this poster, we analyze v2 of π+ and π- produced at mid-rapidity, with the event plane reconstructed from the STAR Beam Beam Counters (BBC). With the pseudo-rapidity gap (Δη >2) between the event plane and particles of interest, we improve our control of the systematics due to the short-range correlations that are not related to the reaction plane. The low possibility of proton registration in the BBC further suppresses the background due to weak decays. We will present pion v2 results for Au +Au collisions at 7.7, 11.5 and 19.6 GeV, and discuss the physics implications of our results in comparison with previous data whose event plane was reconstructed at mid-rapidity.

  10. Synthesis of 4-((1E, 6E)-7-(4-hydroxy-3-methoxyphenyl)-3, 5-dioxohepta-1, 6-dienyl)-2-methoxyphenyl 4-fluorobenzoate, a novel monoester derivative of curcumin, its experimental and theoretical (DFT) studies

    NASA Astrophysics Data System (ADS)

    Srivastava, Sangeeta; Gupta, Preeti; Amandeep; Singh, Ranvijay Pratap

    2016-04-01

    Curcumin (1), isolated as a major component from the chloroform extract of Curcuma longa was converted to its ester derivative 4-((1E, 6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl)-2-methoxyphenyl 4-fluorobenzoate (2). The compound has been characterized with the help of 1H, 13C NMR, UV, IR and mass spectrometry. The molecular geometry of synthesized compound was calculated in ground state by Density functional theory (DFT/B3LYP) using 6-31G (d,p) basis set. 1H and 13C NMR chemical shifts were calculated in ground state by using Gauge-Including Atomic Orbital (GIAO) approach and these values were correlated with experimental observations. The electronic properties such as HOMO and LUMO energies were calculated using time dependent Density Functional Theory (TD-DFT). Stability of the molecule as a result of hyper conjugative interactions and electron delocalization were analysed using Natural bond orbital (NBO) analysis. Intramolecular interactions were analysed by AIM (Atom in molecule) approach. Global reactivity descriptors were calculated to study the reactive site within molecule. The vibrational wavenumbers were calculated using DFT method and assigned with the help of potential energy distribution (PED). First hyperpolarizability values have been calculated to describe the nonlinear optical (NLO) property of the synthesized compounds. Molecular electrostatic potential (MEP) analysis has also been carried out.

  11. Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone as a potent and selective I(Kur) inhibitor.

    PubMed

    Finlay, Heather J; Lloyd, John; Vaccaro, Wayne; Kover, Alexander; Yan, Lin; Bhave, Gauri; Prol, Joseph; Huynh, Tram; Bhandaru, Rao; Caringal, Yolanda; DiMarco, John; Gan, Jinping; Harper, Tim; Huang, Christine; Conder, Mary Lee; Sun, Huabin; Levesque, Paul; Blanar, Michael; Atwal, Karnail; Wexler, Ruth

    2012-04-12

    Previously disclosed dihydropyrazolopyrimidines are potent and selective blockers of I(Kur) current. A potential liability with this chemotype is the formation of a reactive metabolite which demonstrated covalent binding to protein in vitro. When substituted at the 2 or 3 position, this template yielded potent I(Kur) inhibitors, with selectivity over hERG which did not form reactive metabolites. Subsequent optimization for potency and PK properties lead to the discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone (13j), with an acceptable PK profile in preclinical species and potent efficacy in the preclinical rabbit atrial effective refractory period (AERP) model.

  12. 7 CFR 610.5 - Interdisciplinary assistance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Interdisciplinary assistance. 610.5 Section 610.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... Interdisciplinary assistance. Technical assistance is based on the principle that soil, water, plant, and...

  13. 7 CFR 610.5 - Interdisciplinary assistance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Interdisciplinary assistance. 610.5 Section 610.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE CONSERVATION OPERATIONS TECHNICAL ASSISTANCE Conservation Operations §...

  14. 7 CFR 625.5 - Application procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Application procedures. 625.5 Section 625.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... selection. Upon selection for funding, the State Conservationist will issue a public sign-up notice...

  15. 7 CFR 625.5 - Application procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Application procedures. 625.5 Section 625.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... selection. Upon selection for funding, the State Conservationist will issue a public sign-up notice...

  16. 7 CFR 613.5 - PMCs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false PMCs. 613.5 Section 613.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF..., Elsberry, MO, Bridger, MT, Fallon, NV, Cape May Courthouse, NJ, Los Lunas, NM, Big Flats, NY, Bismarck,...

  17. 7 CFR 625.5 - Application procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Application procedures. 625.5 Section 625.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... selection. Upon selection for funding, the State Conservationist will issue a public sign-up notice...

  18. 7 CFR 625.5 - Application procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Application procedures. 625.5 Section 625.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... selection. Upon selection for funding, the State Conservationist will issue a public sign-up notice...

  19. 5''-(4-Nitro-benzyl-idene)-7'-(4-nitro-phen-yl)-1''-methyl-1',3',5',6',7',7a'-hexa-hydro-dispiro-[ace-naphthyl-ene-1,5'-pyrrolo-[1,2-c][1,3]thia-zole-6',3''-piperidine]-2,4''(1H)-dione including an unknown solvate.

    PubMed

    Vishnupriya, R; Suresh, J; Sivakumar, S; Kumar, R Ranjith; Lakshman, P L Nilantha

    2013-01-01

    The title compound, C35H28N4O6S, crystallizes with two mol-ecules in the asymmetric unit. In both mol-ecules, the piperidine ring adopts a shallow-chair conformation, the thia-zole ring adopts a twisted conformation about the Cm-N bond (m = methine) and the pyrrole ring adopts an envelope conformation with the C atom shared with the thia-zole ring as the flap. In the crystal, inversion dimers linked by pairs of C-H⋯O inter-actions generate R 2 (2)(34) loops for one of the asymmetric mol-ecules. Further C-H⋯O links also involving the other mol-ecule lead to a three-dimesional network. The contribution of the highly disordered solvent to the scattering was removed with SQUEEZE option of PLATON [Spek (2009 ▶). Acta Cryst. D65, 148-155]. The solvent contribution is not included in the reported mol-ecular weight and density. PMID:24109305

  20. 7 CFR 1720.6 - Application process.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... application to the Secretary; (2) The application is screened by RUS pursuant to 7 CFR 1720.7(a) of this part... the selection criteria set forth in 7 CFR 1720.7(b) of this part; (4) If RUS provisionally approves... 7 Agriculture 11 2014-01-01 2014-01-01 false Application process. 1720.6 Section...

  1. 6 CFR 5.6 - Responses to requests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Responses to requests. 5.6 Section 5.6 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY DISCLOSURE OF RECORDS AND INFORMATION Freedom of Information Act § 5.6 Responses to requests. (a) Acknowledgements of requests. On receipt of...

  2. (2aR*,5S*,6aS*,8aS*,E)-Ethyl 5-hy­droxy-7,7,8a-trimethyl-8-oxo-2,2a,6,6a,7,8,8a,8b-octa­hydro-1H-penta­leno[1,6-bc]oxepine-4-carboxyl­ate

    PubMed Central

    Mehta, Goverdhan; Kumar, C. S. Ananda; Sen, Saikat

    2012-01-01

    The title compound, C17H24O5, featuring a 2-carbeth­oxy-3-oxepanone unit in its intra­molecularly O—H⋯O hydrogen-bonded enol form, was obtained via [(CF3CO2)2Rh]2-catal­ysed intra­molecular O—H bond insertion in the α-diazo-ω-hy­droxy-β-ketoester, ethyl 4-[(1S,3aS,6R,6aS)-6-hy­droxy-2,2,3a-trimethyl-3-oxo-octa­hydro­penta­len-1-yl]-2-diazo-3-oxobutano­ate. The seven-membered oxacyclic ring, thus constructed on a cis-fused diquinane platform, was found to adopt a distorted boat–sofa conformation. PMID:23476221

  3. 5 CFR 6.6 - Revocation of exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Revocation of exceptions. 6.6 Section 6.6 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES EXCEPTIONS FROM THE COMPETITIVE SERVICE (RULE VI) § 6.6 Revocation of exceptions. OPM may remove any position from or may revoke in...

  4. (2-Amino-7-methyl-4-oxidopteridine-6-carboxyl­ato-κ3 O 4,N 5,O 6)aqua­(ethane-1,2-diamine-κ2 N,N′)nickel(II) dihydrate

    PubMed Central

    Baisya, Siddhartha S.; Roy, Parag S.

    2013-01-01

    The NiII atom in the title complex, [Ni(C8H5N5O3)(C2H8N2)(H2O)]·2H2O, is six-coordinated in a distorted octa­hedral geometry by a tridentate 2-amino-7-methyl-4-oxidopteridine-6-carboxyl­ate (pterin) ligand, a bidentate ancillary ethane-1,2-diamine (en) ligand and a water mol­ecule. The pterin ligand forms two chelate rings. The en and pterin ligands are arranged nearly orthogonally [dihedral angle between the mean plane of the en mol­ecule and the pterin ring = 77.1 (1)°]. N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonds link the complex mol­ecules and lattice water mol­ecules into a three-dimensional network. π–π inter­actions are observed between the pyrazine and pyrimidine rings [centroid–centroid distance = 3.437 (2) Å]. PMID:23424441

  5. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  6. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  7. 7 CFR 774.6 - Eligibility requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false Eligibility requirements. 774.6 Section 774.6 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS EMERGENCY LOAN FOR SEED PRODUCERS PROGRAM § 774.6 Eligibility requirements....

  8. 7 CFR 1957.6 - Appeal reviews.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DC, under the FmHA or its successor agency under Public Law 103-354 Appeal Procedures, 7 CFR part... 7 Agriculture 14 2014-01-01 2014-01-01 false Appeal reviews. 1957.6 Section 1957.6 Agriculture... REGULATIONS (CONTINUED) ASSET SALES Rural Housing Asset Sales § 1957.6 Appeal reviews. The Master...

  9. 7 CFR 1957.6 - Appeal reviews.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DC, under the FmHA or its successor agency under Public Law 103-354 Appeal Procedures, 7 CFR part... 7 Agriculture 14 2011-01-01 2011-01-01 false Appeal reviews. 1957.6 Section 1957.6 Agriculture... REGULATIONS (CONTINUED) ASSET SALES Rural Housing Asset Sales § 1957.6 Appeal reviews. The Master...

  10. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  11. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  12. 7 CFR 650.6 - Categorical exclusions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... These are data gathering and interpretation programs and include: (1) Soil Survey—7 CFR part 611; (2) Snow Survey and Water Supply Forecasts—7 CFR part 612; (3) Plant Materials for Conservation—7 CFR part... Studies under section 6 of Pub. L. 83-566 as amended—7 CFR part 621. (b) When any new action is...

  13. 4-(4-Bromo-phen-yl)-7,7-dimethyl-2-methyl-amino-3-nitro-7,8-di-hydro-4H-chromen-5(6H)-one including an unknown solvate.

    PubMed

    Inglebert, S Antony; Kamalraja, Jayabal; Sethusankar, K; Vasuki, Gnanasambandam

    2014-05-01

    In the title compound, C18H19BrN2O4, the chromene unit is not quite planar (r.m.s. deviation = 0.199 Å), with the methyl C atoms lying 0.027 (4) and 1.929 (4) Å from the mean plane of the chromene unit. The six-membered carbocyclic ring of the chromene moiety adopts an envelope conformation, with the dimethyl-substituted C atom as the flap. The methyl-amine and nitro groups are slightly twisted from the chromene moiety, with C-N-C-O and O-N-C-C torsion angles of 2.7 (4) and -0.4 (4)°, respectively. The dihedral angle between the mean plane of the chromene unit and the benzene ring is 85.61 (13)°. An intra-molecular N-H⋯O hydrogen bond generates an S(6) ring motif, which stabilizes the mol-ecular conformation. In the crystal, mol-ecules are linked via N-H⋯O hydrogen bonds, forming hexa-gonal rings lying parallel to the ab plane. A region of disordered electron density, most probably disordered ethanol solvent mol-ecules, occupying voids of ca 432 Å(3) for an electron count of 158, was treated using the SQUEEZE routine in PLATON [Spek (2009 ▶). Acta Cryst. D65, 148-155]. Their formula mass and unit-cell characteristics were not taken into account during refinement. PMID:24860381

  14. Reaction between enaminones and acetylenic esters in the presence of triphenylphosphine: a convenient synthesis of alkyl 2(1-benzyl-2,4-dioxo-2,3,4,5,6,7-hexahydro-1H-indol-3-yl)acetates.

    PubMed

    Nasiri, Farough; Bayzidi, Massood; Zolali, Amin

    2012-08-01

    One-pot reaction between enaminocarbonyl compounds derived from six-membered 1,3-diketones and substituted benzylamines, and electron-deficient acetylenic esters in the presence of triphenylphosphine lead to alkyl 2-(1-benzyl-6,6-dimethyl-2,4-dioxo-2,3,4,5,6,7-hexahydro-1H-indol-3-yl)acetate derivatives in good yields.

  15. Seismotectonics and seismic quietness of the Oranie region (Western Algeria): The Mascara earthquake of August 18th 1994, Mw = 5.7, Ms = 6.0

    NASA Astrophysics Data System (ADS)

    Ayadi, A.; Ousadou-Ayadi, F.; Bourouis, S.; Benhallou, H.

    The plate dynamics in the central western Mediterranean region is characterised by a collision between the Eurasian and African plates. In response to this dynamics, many systems of faults and folds having a NE-SW and E-W trending have been generated along the Tellian Atlas of Algeria. The Oranie region (north western Algeria) has experienced some significant earthquakes in the last centuries, the most important one is that of Oran city on February 9th 1790, Io = XI which destroyed the town completely and caused the loss of many lives. Since 1790 no other event was so disastrous except that of August 18th 1994, Mw = 5.7, which struck Mascara province (Algeria) at 01 h 13 mn GMT. Since the beginning of this century the region has been dominated by a seismic quietness. Thus, no event with magnitude larger than 5.5 have occurred in this area. In relation with this recent event, a seismotectonic framework summarising the tectonic, seismicity and focal solution results is presented. The Maximum Observed Intensities Map (MOI) made for Algeria (Bezzeghoud et al., 1996) is also used to show that the Mascara region is located in an VIII-X intensity zone, which explain partially the casualties caused by the 18/08/1994 (Mw = 5.7) earthquake. This earthquake is not anomalous compared to historical records but is unusual compared to recorded seismicity of this century. The seismotectonic map made in this study and also the review of the focal solutions given by the EMSC, Harvard, and other authors shows that our event is probably associated with a source belonging to a system of faults located in the vicinity of the village of Hacine where the maximum damage was observed.

  16. 7 CFR 600.6 - Field offices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Field offices. 600.6 Section 600.6 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.6 Field offices. Each field office is under the direction...

  17. 7 CFR 600.6 - Field offices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Field offices. 600.6 Section 600.6 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.6 Field offices. Each field office is under the direction...

  18. 7 CFR 501.6 - Gambling.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Gambling. 501.6 Section 501.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.6 Gambling. Participating...

  19. 7 CFR 501.6 - Gambling.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Gambling. 501.6 Section 501.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.6 Gambling. Participating...

  20. 7 CFR 501.6 - Gambling.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Gambling. 501.6 Section 501.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.6 Gambling. Participating...

  1. 7 CFR 501.6 - Gambling.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Gambling. 501.6 Section 501.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.6 Gambling. Participating...

  2. 7 CFR 501.6 - Gambling.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Gambling. 501.6 Section 501.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.6 Gambling. Participating...

  3. 7 CFR 1126.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1126.6 Section 1126.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1126.6 Supply plant. See § 1000.6....

  4. 7 CFR 1001.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1001.6 Section 1001.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1001.6 Supply plant. See § 1000.6....

  5. 7 CFR 1131.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1131.6 Section 1131.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1131.6 Supply plant. See § 1000.6....

  6. 7 CFR 1126.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1126.6 Section 1126.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1126.6 Supply plant. See § 1000.6....

  7. 7 CFR 1131.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1131.6 Section 1131.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1131.6 Supply plant. See § 1000.6....

  8. 7 CFR 1005.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1005.6 Section 1005.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1005.6 Supply plant. See § 1000.6....

  9. 7 CFR 1006.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1006.6 Section 1006.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1006.6 Supply plant. See § 1000.6....

  10. 7 CFR 1124.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1124.6 Section 1124.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Regulating Handling Definitions § 1124.6 Supply plant. See § 1000.6....

  11. 7 CFR 1006.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1006.6 Section 1006.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1006.6 Supply plant. See § 1000.6....

  12. 7 CFR 1032.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1032.6 Section 1032.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1032.6 Supply plant. See § 1000.6....

  13. 7 CFR 1032.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1032.6 Section 1032.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1032.6 Supply plant. See § 1000.6....

  14. 7 CFR 1124.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1124.6 Section 1124.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Regulating Handling Definitions § 1124.6 Supply plant. See § 1000.6....

  15. 7 CFR 1124.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1124.6 Section 1124.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 1124.6 Supply plant. See § 1000.6....

  16. 7 CFR 1033.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1033.6 Section 1033.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1033.6 Supply plant. See § 1000.6....

  17. 7 CFR 1033.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1033.6 Section 1033.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1033.6 Supply plant. See § 1000.6....

  18. 7 CFR 1006.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1006.6 Section 1006.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1006.6 Supply plant. See § 1000.6....

  19. 7 CFR 1030.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1030.6 Section 1030.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1030.6 Supply plant. See § 1000.6....

  20. 7 CFR 1005.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1005.6 Section 1005.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1005.6 Supply plant. See § 1000.6....

  1. 7 CFR 1007.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1007.6 Section 1007.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1007.6 Supply plant. See § 1000.6....

  2. 7 CFR 1030.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1030.6 Section 1030.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1030.6 Supply plant. See § 1000.6....

  3. 7 CFR 1032.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1032.6 Section 1032.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1032.6 Supply plant. See § 1000.6....

  4. 7 CFR 1033.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1033.6 Section 1033.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1033.6 Supply plant. See § 1000.6....

  5. 7 CFR 1030.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1030.6 Section 1030.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1030.6 Supply plant. See § 1000.6....

  6. 7 CFR 1001.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1001.6 Section 1001.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1001.6 Supply plant. See § 1000.6....

  7. 7 CFR 1126.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1126.6 Section 1126.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1126.6 Supply plant. See § 1000.6....

  8. 7 CFR 1001.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1001.6 Section 1001.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1001.6 Supply plant. See § 1000.6....

  9. 7 CFR 1007.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1007.6 Section 1007.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1007.6 Supply plant. See § 1000.6....

  10. 7 CFR 1005.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1005.6 Section 1005.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1005.6 Supply plant. See § 1000.6....

  11. 7 CFR 1131.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1131.6 Section 1131.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1131.6 Supply plant. See § 1000.6....

  12. 7 CFR 1007.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1007.6 Section 1007.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1007.6 Supply plant. See § 1000.6....

  13. 7 CFR 510.6 - Appeals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Appeals. 510.6 Section 510.6 Agriculture Regulations... PUBLIC INFORMATION § 510.6 Appeals. Any person whose request is denied shall have the right to appeal such denial. Appeals shall be made in accordance with § 1.14 of this title and should be addressed...

  14. 7 CFR 510.6 - Appeals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Appeals. 510.6 Section 510.6 Agriculture Regulations... PUBLIC INFORMATION § 510.6 Appeals. Any person whose request is denied shall have the right to appeal such denial. Appeals shall be made in accordance with § 1.14 of this title and should be addressed...

  15. 7 CFR 510.6 - Appeals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Appeals. 510.6 Section 510.6 Agriculture Regulations... PUBLIC INFORMATION § 510.6 Appeals. Any person whose request is denied shall have the right to appeal such denial. Appeals shall be made in accordance with § 1.14 of this title and should be addressed...

  16. 7 CFR 1030.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1030.6 Section 1030.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1030.6 Supply plant. See § 1000.6....

  17. 7 CFR 1005.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1005.6 Section 1005.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1005.6 Supply plant. See § 1000.6....

  18. 7 CFR 1131.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1131.6 Section 1131.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1131.6 Supply plant. See § 1000.6....

  19. 7 CFR 1005.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1005.6 Section 1005.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1005.6 Supply plant. See § 1000.6....

  20. 7 CFR 1030.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1030.6 Section 1030.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1030.6 Supply plant. See § 1000.6....

  1. 7 CFR 1131.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1131.6 Section 1131.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1131.6 Supply plant. See § 1000.6....

  2. 7 CFR 1007.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1007.6 Section 1007.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1007.6 Supply plant. See § 1000.6....

  3. 7 CFR 1001.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1001.6 Section 1001.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1001.6 Supply plant. See § 1000.6....

  4. 7 CFR 1007.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1007.6 Section 1007.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1007.6 Supply plant. See § 1000.6....

  5. 7 CFR 1006.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1006.6 Section 1006.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1006.6 Supply plant. See § 1000.6....

  6. 7 CFR 1126.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1126.6 Section 1126.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1126.6 Supply plant. See § 1000.6....

  7. 7 CFR 1126.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1126.6 Section 1126.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1126.6 Supply plant. See § 1000.6....

  8. 7 CFR 1033.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1033.6 Section 1033.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1033.6 Supply plant. See § 1000.6....

  9. 7 CFR 1006.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1006.6 Section 1006.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1006.6 Supply plant. See § 1000.6....

  10. 7 CFR 1124.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1124.6 Section 1124.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 1124.6 Supply plant. See § 1000.6....

  11. 7 CFR 1033.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1033.6 Section 1033.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1033.6 Supply plant. See § 1000.6....

  12. 7 CFR 1124.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1124.6 Section 1124.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 1124.6 Supply plant. See § 1000.6....

  13. 7 CFR 1032.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1032.6 Section 1032.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1032.6 Supply plant. See § 1000.6....

  14. 7 CFR 1032.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1032.6 Section 1032.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1032.6 Supply plant. See § 1000.6....

  15. 7 CFR 1001.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1001.6 Section 1001.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1001.6 Supply plant. See § 1000.6....

  16. 7 CFR 550.6 - Duration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Duration. 550.6 Section 550.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE GENERAL ADMINISTRATIVE POLICY FOR NON-ASSISTANCE COOPERATIVE AGREEMENTS General § 550.6 Duration. REE...

  17. 7 CFR 550.6 - Duration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Duration. 550.6 Section 550.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE GENERAL ADMINISTRATIVE POLICY FOR NON-ASSISTANCE COOPERATIVE AGREEMENTS General § 550.6 Duration. REE...

  18. 7 CFR 500.6 - Gambling.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Gambling. 500.6 Section 500.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL ARBORETUM Conduct on U.S. National Arboreturm Property § 500.6 Gambling. Participating in...

  19. 7 CFR 500.6 - Gambling.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Gambling. 500.6 Section 500.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL ARBORETUM Conduct on U.S. National Arboreturm Property § 500.6 Gambling. Participating in...

  20. 7 CFR 500.6 - Gambling.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Gambling. 500.6 Section 500.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL ARBORETUM Conduct on U.S. National Arboreturm Property § 500.6 Gambling. Participating in...

  1. 4 CFR 5.6 - Allowances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Allowances. 5.6 Section 5.6 Accounts GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL SYSTEM COMPENSATION § 5.6 Allowances. The provisions of chapter 59 of title 5, U.S. Code and the implementing regulations for the Executive Branch apply to Government...

  2. Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions.

    PubMed

    Kemnitzer, William; Kasibhatla, Shailaja; Jiang, Songchun; Zhang, Hong; Zhao, Jianghong; Jia, Shaojuan; Xu, Lifen; Crogan-Grundy, Candace; Denis, Réal; Barriault, Nancy; Vaillancourt, Louis; Charron, Sylvie; Dodd, Jennifer; Attardo, Giorgio; Labrecque, Denis; Lamothe, Serge; Gourdeau, Henriette; Tseng, Ben; Drewe, John; Cai, Sui Xiong

    2005-11-01

    As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the SAR of 4-aryl-4H-chromenes with modifications at the 7- and 5-, 6-, 8-positions. It was found that a small hydrophobic group, such as NMe2, NH2, NHEt, and OMe, is preferred at the 7-position. Di-substitution at either the 5,7-positions or the 6,7-positions generally led to a large decrease in potency. Di-substitution at the 7,8-positions, in general, was found to result in potent compounds. 7-NMe2, 7-NHEt, 7-OMe, and 7,8-di-NH2 analogs were found to have similar SAR for the 4-aryl group, and several 7-substituted and 7,8-di-substituted analogs were found to have similar potencies as the lead compound MX58151 (2a) both as caspase activators and inhibitors of cell proliferation.

  3. Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice

    SciTech Connect

    Kopec, Anna K.; D'Souza, Michelle L.; Mets, Bryan D.; Burgoon, Lyle D.; Reese, Sarah E.; Archer, Kellie J.; Potter, Dave; Tashiro, Colleen; Sharratt, Bonnie; Harkema, Jack R.; Zacharewski, Timothy R.

    2011-10-15

    Interactions between environmental contaminants can lead to non-additive effects that may affect the toxicity and risk assessment of a mixture. Comprehensive time course and dose-response studies with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), non-dioxin-like 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) and their mixture were performed in immature, ovariectomized C57BL/6 mice. Mice were gavaged once with 30 {mu}g/kg TCDD, 300 mg/kg PCB153, a mixture of 30 {mu}g/kg TCDD with 300 mg/kg PCB153 (MIX) or sesame oil vehicle for 4,12, 24,72 or 168 h. In the 24 h dose-response study, animals were gavaged with TCDD (0.3,1, 3, 6, 10, 15, 30, 45 {mu}g/kg), PCB153 (3,10, 30, 60, 100, 150, 300, 450 mg/kg), MIX (0.3 + 3, 1 + 10, 3 + 30, 6 + 60, 10 + 100, 15 + 150, 30 + 300, 45 {mu}g/kg TCDD + 450 mg/kg PCB153, respectively) or vehicle. All three treatments significantly increased relative liver weights (RLW), with MIX eliciting significantly greater increases compared to TCDD and PCB153 alone. Histologically, MIX induced hepatocellular hypertrophy, vacuolization, inflammation, hyperplasia and necrosis, a combination of TCDD and PCB153 responses. Complementary lipid analyses identified significant increases in hepatic triglycerides in MIX and TCDD samples, while PCB153 had no effect on lipids. Hepatic PCB153 levels were also significantly increased with TCDD co-treatment. Microarray analysis identified 167 TCDD, 185 PCB153 and 388 MIX unique differentially expressed genes. Statistical modeling of quantitative real-time PCR analysis of Pla2g12a, Serpinb6a, Nqo1, Srxn1, and Dysf verified non-additive expression following MIX treatment compared to TCDD and PCB153 alone. In summary, TCDD and PCB153 co-treatment elicited specific non-additive gene expression effects that are consistent with RLW increases, histopathology, and hepatic lipid accumulation. - Graphical abstract: Display Omitted Highlights: > MIX (TCDD:PCB153 at 1:10,000 ratio) exposure leads to non-additive gene expression

  4. The 16 April 2016, MW 7.8 (MS 7.5) Ecuador earthquake: A quasi-repeat of the 1942 MS 7.5 earthquake and partial re-rupture of the 1906 MS 8.6 Colombia-Ecuador earthquake

    NASA Astrophysics Data System (ADS)

    Ye, Lingling; Kanamori, Hiroo; Avouac, Jean-Philippe; Li, Linyan; Cheung, Kwok Fai; Lay, Thorne

    2016-11-01

    The 2016 Ecuador MW 7.8 earthquake ruptured the subduction zone boundary between the Nazca and South American plates. Joint modeling of seismic and tsunami observations indicates an ∼120 km long rupture area beneath the coastline north of the 1998 MW 7.2 rupture. The slip distribution reveals two discrete asperities near the hypocenter and around the equator. Their locations and the patchy pattern are consistent with the prior interseismic geodetic strain, which showed highly locked patches also beneath the coastline. Aftershocks cluster along two streaks, one aligned nearly parallel to the plate convergence direction up-dip of the main slip patches, and the other on a trench-perpendicular lineation south of the 1958 rupture zone. Comparisons of seismic waveforms and magnitudes show that the 2016 event and 1942 earthquakes have similar surface wave magnitude (MS 7.5), overlapping rupture areas, and similar main pulses of moment rate. The same area ruptured as the southernmost portion of the larger earthquake of 1906 (MW 8.6, MS 8.6). The seismic behavior reflects persistent heterogeneous frictional properties of the Colombia-Ecuador megathrust.

  5. 15 CFR 6.5 - Effective date of adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... INFLATION ADJUSTMENTS § 6.5 Effective date of adjustments. The adjustments made by § 6.4 of this part, of... December 7, 2012, and before the effective date of any future inflation adjustment thereto made...

  6. 15 CFR 6.5 - Effective date of adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... INFLATION ADJUSTMENTS § 6.5 Effective date of adjustments. The adjustments made by § 6.4 of this part, of... December 7, 2012, and before the effective date of any future inflation adjustment thereto made...

  7. Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile.

    PubMed

    Partyka, Anna; Chłoń-Rzepa, Grażyna; Wasik, Anna; Jastrzębska-Więsek, Magdalena; Bucki, Adam; Kołaczkowski, Marcin; Satała, Grzegorz; Bojarski, Andrzej J; Wesołowska, Anna

    2015-01-01

    Continuing our earlier study in a group of purine-2,6-dione derivatives of long chain arylpiperazines (LCAPs), a series of 8-unsubstituted 7-phenylpiperazin-4-yl-alkyl (4-14) and 7-tetrahydroisoquinolinyl-alkyl (15-17) analogues were synthesized and their serotonin 5-HT1A, 5-HT2A, 5-HT6, 5-HT7 and dopamine D2 receptor affinities were determined. The study allowed us to identify some potent 5-HT1A receptor ligands with additional moderate affinity for 5-HT2A, 5-HT7 and dopamine D2 receptors. Compounds 9, 12, 13 and 14, with the highest 5HT1A receptor affinity, were selected for further functional in vivo studies and behavioural evaluation of antidepressant- and antianxiety-like activity. Compounds 9, 12 and 13 showed features of agonists of pre- and/or post-synaptic 5-HT1A receptors, whereas 14 was classified as an antagonist of postsynaptic sites. Moreover, derivatives 9 and 14 acted as antagonists of 5-HT2A receptors. In behavioural studies, compounds 9 and 13 showed antidepressant-like activity in the mouse forced swim test, and their effects were similar or stronger than those of imipramine. Compounds 9, 12 and 14 displayed potential anxiolytic-like properties in the mouse four-plate test, similar or even greater than those of the reference anxiolytic drug, diazepam.

  8. 7 CFR 1781.6 - Loan purposes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of Agriculture under the Act (7 CFR part 21), and the Memorandum of Understanding Between NRCS and... 7 Agriculture 12 2014-01-01 2013-01-01 true Loan purposes. 1781.6 Section 1781.6 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF...

  9. Multi-Step Protocol for Automatic Evaluation of Docking Results Based on Machine Learning Methods--A Case Study of Serotonin Receptors 5-HT(6) and 5-HT(7).

    PubMed

    Smusz, Sabina; Mordalski, Stefan; Witek, Jagna; Rataj, Krzysztof; Kafel, Rafał; Bojarski, Andrzej J

    2015-04-27

    Molecular docking, despite its undeniable usefulness in computer-aided drug design protocols and the increasing sophistication of tools used in the prediction of ligand-protein interaction energies, is still connected with a problem of effective results analysis. In this study, a novel protocol for the automatic evaluation of numerous docking results is presented, being a combination of Structural Interaction Fingerprints and Spectrophores descriptors, machine-learning techniques, and multi-step results analysis. Such an approach takes into consideration the performance of a particular learning algorithm (five machine learning methods were applied), the performance of the docking algorithm itself, the variety of conformations returned from the docking experiment, and the receptor structure (homology models were constructed on five different templates). Evaluation using compounds active toward 5-HT6 and 5-HT7 receptors, as well as additional analysis carried out for beta-2 adrenergic receptor ligands, proved that the methodology is a viable tool for supporting virtual screening protocols, enabling proper discrimination between active and inactive compounds.

  10. 3-(2,3,5,6,7,8-Hexahydro-1H-cyclo­penta­[b]quinolin-9-yl)-1,5-bis­(4-methoxy­phen­yl)biuret

    PubMed Central

    Sakurai, Kaori; Noguchi, Keiichi; Nishibe, Koichiro

    2010-01-01

    Ipidacrine (2,3,5,6,7,8-hexa­hydro-1H-cyclo­penta­[b]quinolin-9-amine) was reacted with 4-methoxy­phenyl isocyanate to give the title compound, C28H30N4O4. An intra­molecular N—H⋯O hydrogen bond results in an essentially planar [r.m.s. deviation from the mean plane is 0.126 (1) Å] conformation for the biuret unit. The central ring of the quinoline unit is twisted by 78.2 (1)° with respect to the biuret mean plane, whereas the two 4-methoxy­benzene rings are twisted out of this plane by 24.3 (1)° and 48.5 (1)°, resulting in an overall propeller-like structure. An inter­molecular N—H⋯N hydrogen bond between the biuret NH atom and the quinoline ring nitro­gen defines the crystal packing. PMID:21580406

  11. Discovery of 8-Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)

    PubMed Central

    2015-01-01

    The success of imatinib, a BCR-ABL inhibitor for the treatment of chronic myelogenous leukemia, has created a great impetus for the development of additional kinase inhibitors as therapeutic agents. However, the complexity of cancer has led to recent interest in polypharmacological approaches for developing multikinase inhibitors with low toxicity profiles. With this goal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structure–activity relationship trends that can be exploited in the design of potent kinase inhibitors. One compound, 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x), was found to be the most active, inducing apoptosis of tumor cells at a concentration of approximately 30–100 nM. In vitro kinase profiling revealed that 7x is a multikinase inhibitor with potent inhibitory activity against the CDK4/CYCLIN D1 and ARK5 kinases. Here, we report the synthesis, structure–activity relationship, kinase inhibitory profile, in vitro cytotoxicity, and in vivo tumor regression studies by this lead compound. PMID:24417566

  12. Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).

    PubMed

    Reddy, M V Ramana; Akula, Balireddy; Cosenza, Stephen C; Athuluridivakar, Saikrishna; Mallireddigari, Muralidhar R; Pallela, Venkat R; Billa, Vinay K; Subbaiah, D R C Venkata; Bharathi, E Vijaya; Vasquez-Del Carpio, Rodrigo; Padgaonkar, Amol; Baker, Stacey J; Reddy, E Premkumar

    2014-02-13

    The success of imatinib, a BCR-ABL inhibitor for the treatment of chronic myelogenous leukemia, has created a great impetus for the development of additional kinase inhibitors as therapeutic agents. However, the complexity of cancer has led to recent interest in polypharmacological approaches for developing multikinase inhibitors with low toxicity profiles. With this goal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structure-activity relationship trends that can be exploited in the design of potent kinase inhibitors. One compound, 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x), was found to be the most active, inducing apoptosis of tumor cells at a concentration of approximately 30-100 nM. In vitro kinase profiling revealed that 7x is a multikinase inhibitor with potent inhibitory activity against the CDK4/CYCLIN D1 and ARK5 kinases. Here, we report the synthesis, structure-activity relationship, kinase inhibitory profile, in vitro cytotoxicity, and in vivo tumor regression studies by this lead compound.

  13. 6 CFR 25.7 - Litigation management.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Litigation management. 25.7 Section 25.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REGULATIONS TO SUPPORT ANTI-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.7 Litigation management. (a) Liability for all...

  14. 6 CFR 25.7 - Litigation management.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Litigation management. 25.7 Section 25.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REGULATIONS TO SUPPORT ANTI-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.7 Litigation management. (a) Liability for all...

  15. 6 CFR 7.26 - Derivative classification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... amended, 32 CFR 2001.22, and internal DHS guidance provided by the Chief Security Officer. ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Derivative classification. 7.26 Section 7.26... INFORMATION Classified Information § 7.26 Derivative classification. (a) Derivative classification is...

  16. 6 CFR 7.26 - Derivative classification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... amended, 32 CFR 2001.22, and internal DHS guidance provided by the Chief Security Officer. ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Derivative classification. 7.26 Section 7.26... INFORMATION Classified Information § 7.26 Derivative classification. (a) Derivative classification is...

  17. 6 CFR 7.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Purpose. 7.1 Section 7.1 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.1 Purpose. The purpose of this part is to ensure that information within the Department of Homeland...

  18. 6 CFR 7.11 - Components' responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Components' responsibilities. 7.11 Section 7.11 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION Administration § 7.11 Components' responsibilities. Each DHS component shall appoint a...

  19. 6 CFR 7.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope..., National Industrial Security Program, and its implementing directives. (c) This part is independent of...

  20. 6 CFR 13.7 - Complaint.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Complaint. 13.7 Section 13.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.7 Complaint. (a) On or after the date the Department of Justice approves the issuance of a Complaint in...

  1. 6 CFR 7.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope..., National Industrial Security Program, and its implementing directives. (c) This part is independent of...

  2. 6 CFR 7.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Definitions. 7.3 Section 7.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.3... in 32 CFR parts 2001 and 2004, are applicable to this part....

  3. 6 CFR 7.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Definitions. 7.3 Section 7.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.3... in 32 CFR parts 2001 and 2004, are applicable to this part....

  4. 6 CFR 7.11 - Components' responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Components' responsibilities. 7.11 Section 7.11 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION Administration § 7.11 Components' responsibilities. Each DHS component shall appoint a...

  5. 6 CFR 7.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Purpose. 7.1 Section 7.1 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.1 Purpose. The purpose of this part is to ensure that information within the Department of Homeland...

  6. 6 CFR 7.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope..., National Industrial Security Program, and its implementing directives. (c) This part is independent of...

  7. 6 CFR 7.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope..., National Industrial Security Program, and its implementing directives. (c) This part is independent of...

  8. 6 CFR 7.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Definitions. 7.3 Section 7.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.3... in 32 CFR parts 2001 and 2004, are applicable to this part....

  9. 6 CFR 13.7 - Complaint.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Complaint. 13.7 Section 13.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.7 Complaint. (a) On or after the date the Department of Justice approves the issuance of a Complaint in...

  10. 6 CFR 7.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Purpose. 7.1 Section 7.1 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.1 Purpose. The purpose of this part is to ensure that information within the Department of Homeland...

  11. 6 CFR 7.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Definitions. 7.3 Section 7.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.3... in 32 CFR parts 2001 and 2004, are applicable to this part....

  12. 6 CFR 7.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Purpose. 7.1 Section 7.1 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.1 Purpose. The purpose of this part is to ensure that information within the Department of Homeland...

  13. 6 CFR 25.7 - Litigation management.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Litigation management. 25.7 Section 25.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REGULATIONS TO SUPPORT ANTI-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.7 Litigation management. (a) Liability for all...

  14. 6 CFR 7.11 - Components' responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Components' responsibilities. 7.11 Section 7.11 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION Administration § 7.11 Components' responsibilities. Each DHS component shall appoint a...

  15. 6 CFR 7.28 - Automatic declassification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Automatic declassification. 7.28 Section 7.28 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION Classified Information § 7.28 Automatic declassification. (a) Subject to paragraph (b) of...

  16. 6 CFR 7.26 - Derivative classification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... amended, 32 CFR 2001.22, and internal DHS guidance provided by the Chief Security Officer. ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Derivative classification. 7.26 Section 7.26... INFORMATION Classified Information § 7.26 Derivative classification. (a) Derivative classification is...

  17. Modeling, Synthesis and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Novel Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254)

    PubMed Central

    Jurutka, Peter W.; Kaneko, Ichiro; Yang, Joanna; Bhogal, Jaskaran S.; Swierski, Johnathon C.; Tabacaru, Christa R.; Montano, Luis A.; Huynh, Chanh C.; Jama, Rabia A.; Mahelona, Ryan D.; Sarnowski, Joseph T.; Marcus, Lisa M.; Quezada, Alexis; Lemming, Brittney; Tedesco, Maria A.; Fischer, Audra J.; Mohamed, Said A.; Ziller, Joseph W.; Ma, Ning; Gray, Geoffrey M.; van der Vaart, Arjan; Marshall, Pamela A.; Wagner, Carl E.

    2014-01-01

    Three unreported analogs of 4-[1-(3,5,5,8,8-pentamethyl-5-6-7-8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), otherwise known as bexarotene, as well as four novel analogs of (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254) are described, and evaluated for their retinoid-X-receptor (RXR)-selective agonism. Compound 1 has FDA approval as a treatment for cutaneous T-cell lymphoma (CTCL); though, treatment with 1 can elicit side-effects by disrupting other RXR-heterodimer receptor pathways. Of the 7 modeled novel compounds, all analogs stimulate RXR-regulated transcription in mammalian-2-hybrid and RXRE-mediated assays, possess comparable or elevated biological activity based on EC50 profiles, and retain similar or improved apoptotic activity in CTCL assays compared to 1. All novel compounds demonstrate selectivity for RXR and minimal crossover onto the retinoic-acid-receptor (RAR) compared to all-trans-retinoic acid, with select analogs also reducing inhibition of other RXR-dependent pathways (e.g., VDR-RXR). Our results demonstrate that further improvements in biological potency and selectivity of bexarotene can be achieved through rational drug design. PMID:24180745

  18. Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for induction of CYP1A1, CYP1A2 and thymic atrophy in female Harlan Sprague-Dawley rats.

    PubMed

    Hooth, Michelle J; Nyska, Abraham; Fomby, Laurene M; Vasconcelos, Daphne Y; Vallant, Molly; DeVito, Michael J; Walker, Nigel J

    2012-11-15

    In this study we assessed the relative toxicity and potency of the chlorinated naphthalenes 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) and 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) relative to that of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Chemicals were administered in corn oil:acetone (99:1) by gavage to female Harlan Sprague-Dawley rats at dosages of 0 (vehicle), 500, 1500, 5000, 50,000 and 500,000 ng/kg (PCN 66 and PCN 67) and 1, 3, 10, 100, and 300 ng/kg (TCDD) for 2 weeks. Histopathologic changes were observed in the thymus, liver and lung of TCDD treated animals and in the liver and thymus of PCN treated animals. Significant increases in CYP1A1 and CYP1A2 associated enzyme activity were observed in all animals exposed to TCDD, PCN 66 and PCN 67. Dose response modeling of CYP1A1, CYP1A2 and thymic atrophy gave ranges of estimated relative potencies, as compared to TCDD, of 0.0015-0.0072, for PCN 66 and 0.00029-0.00067 for PCN 67. Given that PCN 66 and PCN 67 exposure resulted in biochemical and histopathologic changes similar to that seen with TCDD, this suggests that they should be included in the WHO toxic equivalency factor (TEF) scheme, although the estimated relative potencies indicate that these hexachlorinated naphthalenes should not contribute greatly to the overall human body burden of dioxin-like activity.

  19. z ≳ 7 Galaxies with Red Spitzer/IRAC [3.6]-[4.5] Colors in the Full CANDELS Data Set: The Brightest-Known Galaxies at z ~ 7-9 and a Probable Spectroscopic Confirmation at z = 7.48

    NASA Astrophysics Data System (ADS)

    Roberts-Borsani, G. W.; Bouwens, R. J.; Oesch, P. A.; Labbe, I.; Smit, R.; Illingworth, G. D.; van Dokkum, P.; Holden, B.; Gonzalez, V.; Stefanon, M.; Holwerda, B.; Wilkins, S.

    2016-06-01

    We identify four unusually bright (H {}160,{AB} < 25.5) galaxies from Hubble Space Telescope (HST) and Spitzer CANDELS data with probable redshifts z ˜ 7–9. These identifications include the brightest-known galaxies to date at z ≳ 7.5. As Y-band observations are not available over the full CANDELS program to perform a standard Lyman-break selection of z > 7 galaxies, we employ an alternate strategy using deep Spitzer/IRAC data. We identify z ˜ 7.1–9.1 galaxies by selecting z ≳ 6 galaxies from the HST CANDELS data that show quite red IRAC [3.6]‑[4.5] colors, indicating strong [O iii]+Hβ lines in the 4.5 μm band. This selection strategy was validated using a modest sample for which we have deep Y-band coverage, and subsequently used to select the brightest z ≥ 7 sources. Applying the IRAC criteria to all HST-selected optical dropout galaxies over the full ˜900 arcmin2 of the CANDELS survey revealed four unusually bright z ˜ 7.1, 7.6, 7.9, and 8.6 candidates. The median [3.6]‑[4.5] color of our selected z ˜ 7.1–9.1 sample is consistent with rest-frame [O iii]+Hβ EWs of ˜1500 Å in the [4.5] band. Keck/MOSFIRE spectroscopy has been independently reported for two of our selected sources, showing Lyα at redshifts of 7.7302 ± 0.0006 and {8.683}-0.004+0.001, respectively. We present similar Keck/MOSFIRE spectroscopy for a third selected galaxy with a probable 4.7σ Lyα line at z spec = 7.4770 ± 0.0008. All three have H160-band magnitudes of ˜25 mag and are ˜0.5 mag more luminous (M 1600 ˜ ‑22.0) than any previously discovered z ˜ 8 galaxy, with important implications for the UV luminosity function (LF). Our three brightest and highest redshift z > 7 galaxies all lie within the CANDELS-EGS field, providing a dramatic illustration of the potential impact of field-to-field variance.

  20. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  1. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  2. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  3. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  4. 1 CFR 5.6 - Daily publication.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Daily publication. 5.6 Section 5.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.6 Daily publication. There shall be an edition of the Federal Register published for each official Federal working day....

  5. VirB6 Is Required for Stabilization of VirB5 and VirB3 and Formation of VirB7 Homodimers in Agrobacterium tumefaciens

    PubMed Central

    Hapfelmeier, Siegfried; Domke, Natalie; Zambryski, Patricia C.; Baron, Christian

    2000-01-01

    VirB6 from Agrobacterium tumefaciens is an essential component of the type IV secretion machinery for T pilus formation and genetic transformation of plants. Due to its predicted topology as a polytopic inner membrane protein, it was proposed to form the transport pore for cell-to-cell transfer of genetic material and proteinaceous virulence factors. Here, we show that the absence of VirB6 leads to reduced cellular levels of VirB5 and VirB3, which were proposed to assist T pilus formation as minor component(s) or assembly factor(s), respectively. Overexpression of virB6 in trans restored levels of cell-bound and T pilus-associated VirB5 to wild type but did not restore VirB3 levels. Thus, VirB6 has a stabilizing effect on VirB5 accumulation, thereby regulating T pilus assembly. In the absence of VirB6, cell-bound VirB7 monomers and VirB7-VirB9 heterodimers were reduced and VirB7 homodimer formation was abolished. This effect could not be restored by expression of VirB6 in trans. Expression of TraD, a component of the transfer machinery of the IncN plasmid pKM101, with significant sequence similarity to VirB6, restored neither protein levels nor bacterial virulence but partly permitted T pilus formation in a virB6 deletion strain. VirB6 may therefore regulate T pilus formation by direct interaction with VirB5, and wild-type levels of VirB3 and VirB7 homodimers are not required. PMID:10913084

  6. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  7. 7 CFR 1540.6 - Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Information. 1540.6 Section 1540.6 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF... § 1540.6 Information. Persons desiring information from the Department of Agriculture regarding...

  8. 7 CFR 2900.6 - Effective date.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Effective date. 2900.6 Section 2900.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ENERGY POLICY AND NEW USES, DEPARTMENT OF AGRICULTURE ESSENTIAL AGRICULTURAL USES AND VOLUMETRIC REQUIREMENTS-NATURAL GAS POLICY ACT § 2900.6...

  9. 7 CFR 201.6 - Germination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Germination. 201.6 Section 201.6 Agriculture... REGULATIONS Records for Agricultural and Vegetable Seeds § 201.6 Germination. The complete record shall include the records of all laboratory tests for germination and hard seed for each lot of seed offered...

  10. 7 CFR 201.6 - Germination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Germination. 201.6 Section 201.6 Agriculture... REGULATIONS Records for Agricultural and Vegetable Seeds § 201.6 Germination. The complete record shall include the records of all laboratory tests for germination and hard seed for each lot of seed offered...

  11. 7 CFR 201.6 - Germination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Germination. 201.6 Section 201.6 Agriculture... REGULATIONS Records for Agricultural and Vegetable Seeds § 201.6 Germination. The complete record shall include the records of all laboratory tests for germination and hard seed for each lot of seed offered...

  12. 7 CFR 201.6 - Germination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Germination. 201.6 Section 201.6 Agriculture... REGULATIONS Records for Agricultural and Vegetable Seeds § 201.6 Germination. The complete record shall include the records of all laboratory tests for germination and hard seed for each lot of seed offered...

  13. 7 CFR 201.6 - Germination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Germination. 201.6 Section 201.6 Agriculture... REGULATIONS Records for Agricultural and Vegetable Seeds § 201.6 Germination. The complete record shall include the records of all laboratory tests for germination and hard seed for each lot of seed offered...

  14. 7 CFR 2903.6 - Project types.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Project types. 2903.6 Section 2903.6 Agriculture... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Program Description § 2903.6 Project types. OEPNU intends to... predetermined project period with a statement of intention to provide additional support at a future...

  15. 7 CFR 2903.6 - Project types.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Project types. 2903.6 Section 2903.6 Agriculture... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Program Description § 2903.6 Project types. OEPNU intends to... predetermined project period with a statement of intention to provide additional support at a future...

  16. 7 CFR 2903.6 - Project types.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Project types. 2903.6 Section 2903.6 Agriculture... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Program Description § 2903.6 Project types. OEPNU intends to... predetermined project period with a statement of intention to provide additional support at a future...

  17. 7 CFR 6.36 - Miscellaneous.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Miscellaneous. 6.36 Section 6.36 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Dairy Tariff-Rate Import Quota Licensing § 6.36... proper postage affixed and properly addressed to the Dairy Import Licensing Group, STOP 1021,...

  18. 7 CFR 6.33 - License fee.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false License fee. 6.33 Section 6.33 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Dairy Tariff-Rate Import Quota Licensing § 6.33 License fee. (a) A fee will be assessed each quota year for each license to defray the Department's...

  19. 7 CFR 6.36 - Miscellaneous.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Miscellaneous. 6.36 Section 6.36 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Dairy Tariff-Rate Import Quota Licensing § 6.36... proper postage affixed and properly addressed to the Dairy Import Licensing Group, STOP 1021,...

  20. 7 CFR 6.40 - General.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false General. 6.40 Section 6.40 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Price-Undercutting of Domestic Cheese by Quota Cheeses § 6... of Agriculture as to whether the price at which any article of quota cheese is being offered for...

  1. 7 CFR 6.40 - General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false General. 6.40 Section 6.40 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Price-Undercutting of Domestic Cheese by Quota Cheeses § 6... of Agriculture as to whether the price at which any article of quota cheese is being offered for...

  2. 7 CFR 6.40 - General.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false General. 6.40 Section 6.40 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Price-Undercutting of Domestic Cheese by Quota Cheeses § 6... of Agriculture as to whether the price at which any article of quota cheese is being offered for...

  3. 7 CFR 6.40 - General.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false General. 6.40 Section 6.40 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Price-Undercutting of Domestic Cheese by Quota Cheeses § 6... of Agriculture as to whether the price at which any article of quota cheese is being offered for...

  4. 7 CFR 6.40 - General.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false General. 6.40 Section 6.40 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Price-Undercutting of Domestic Cheese by Quota Cheeses § 6... of Agriculture as to whether the price at which any article of quota cheese is being offered for...

  5. 7 CFR 3411.6 - Grant awards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Grant awards. 3411.6 Section 3411.6 Agriculture....6 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding... and conditions of the award, the applicable Federal cost principles, and the Department's...

  6. 7 CFR 33.6 - Package.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Package. 33.6 Section 33.6 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.6 Package. Package means any container...

  7. 7 CFR 1540.6 - Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Information. 1540.6 Section 1540.6 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF... § 1540.6 Information. Persons desiring information from the Department of Agriculture regarding...

  8. 7 CFR 1540.6 - Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Information. 1540.6 Section 1540.6 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF... § 1540.6 Information. Persons desiring information from the Department of Agriculture regarding...

  9. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  10. 7 CFR 1540.6 - Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Information. 1540.6 Section 1540.6 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF... § 1540.6 Information. Persons desiring information from the Department of Agriculture regarding...

  11. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  12. 7 CFR 1540.6 - Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Information. 1540.6 Section 1540.6 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF... § 1540.6 Information. Persons desiring information from the Department of Agriculture regarding...

  13. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  14. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  15. 7 CFR 3200.6 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Restrictions. 3200.6 Section 3200.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF PROCUREMENT AND PROPERTY MANAGEMENT, DEPARTMENT OF AGRICULTURE DEPARTMENT OF AGRICULTURE GUIDELINES FOR THE ACQUISITION AND TRANSFER OF EXCESS PERSONAL PROPERTY § 3200.6 Restrictions....

  16. 7 CFR 3200.6 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Restrictions. 3200.6 Section 3200.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF PROCUREMENT AND PROPERTY MANAGEMENT, DEPARTMENT OF AGRICULTURE DEPARTMENT OF AGRICULTURE GUIDELINES FOR THE ACQUISITION AND TRANSFER OF EXCESS PERSONAL PROPERTY § 3200.6 Restrictions....

  17. 7 CFR 3200.6 - Restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Restrictions. 3200.6 Section 3200.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF PROCUREMENT AND PROPERTY MANAGEMENT, DEPARTMENT OF AGRICULTURE DEPARTMENT OF AGRICULTURE GUIDELINES FOR THE ACQUISITION AND TRANSFER OF EXCESS PERSONAL PROPERTY § 3200.6 Restrictions....

  18. 7 CFR 3200.6 - Restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Restrictions. 3200.6 Section 3200.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF PROCUREMENT AND PROPERTY MANAGEMENT, DEPARTMENT OF AGRICULTURE DEPARTMENT OF AGRICULTURE GUIDELINES FOR THE ACQUISITION AND TRANSFER OF EXCESS PERSONAL PROPERTY § 3200.6 Restrictions....

  19. 7 CFR 3200.6 - Restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Restrictions. 3200.6 Section 3200.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF PROCUREMENT AND PROPERTY MANAGEMENT, DEPARTMENT OF AGRICULTURE DEPARTMENT OF AGRICULTURE GUIDELINES FOR THE ACQUISITION AND TRANSFER OF EXCESS PERSONAL PROPERTY § 3200.6 Restrictions....

  20. 7 CFR 247.6 - State Plan.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false State Plan. 247.6 Section 247.6 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.6 State Plan. (a) What is the State Plan? The State Plan is a document that describes how the State agency will operate CSFP and...

  1. 7 CFR 247.6 - State Plan.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false State Plan. 247.6 Section 247.6 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.6 State Plan. (a) What is the State Plan? The State Plan is a document that describes how the State agency will operate CSFP and...

  2. 7 CFR 247.6 - State Plan.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false State Plan. 247.6 Section 247.6 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.6 State Plan. (a) What is the State Plan? The State Plan is a document that describes how the State agency will operate CSFP and...

  3. 7 CFR 275.6 - Management units.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Management units. 275.6 Section 275.6 Agriculture... FOOD STAMP AND FOOD DISTRIBUTION PROGRAM PERFORMANCE REPORTING SYSTEM Management Evaluation (ME) Reviews § 275.6 Management units. (a) Establishment of management units. For the purpose of ME...

  4. 7 CFR 930.6 - District.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false District. 930.6 Section 930.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Definitions § 930.6 District. District means one of the subdivisions of the production area described in §...

  5. 7 CFR 63.6 - Fiscal year.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Fiscal year. 63.6 Section 63.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections... CENTER General Provisions Definitions § 63.6 Fiscal year. Fiscal year means a calendar year or any...

  6. 7 CFR 63.6 - Fiscal year.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Fiscal year. 63.6 Section 63.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections... CENTER General Provisions Definitions § 63.6 Fiscal year. Fiscal year means a calendar year or any...

  7. 7 CFR 915.6 - Fiscal year.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Fiscal year. 915.6 Section 915.6 Agriculture... Regulating Handling Definitions § 915.6 Fiscal year. Fiscal year means the twelve-month period ending March 31 of each year....

  8. 7 CFR 987.6 - Crop year.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Crop year. 987.6 Section 987.6 Agriculture Regulations... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.6 Crop year. Crop year means the 12-month period beginning October 1 of each year and ending September 30 of the following year....

  9. 7 CFR 63.6 - Fiscal year.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Fiscal year. 63.6 Section 63.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections... CENTER General Provisions Definitions § 63.6 Fiscal year. Fiscal year means a calendar year or any...

  10. 7 CFR 915.6 - Fiscal year.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Fiscal year. 915.6 Section 915.6 Agriculture... Regulating Handling Definitions § 915.6 Fiscal year. Fiscal year means the twelve-month period ending March 31 of each year....

  11. 7 CFR 987.6 - Crop year.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Crop year. 987.6 Section 987.6 Agriculture Regulations... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.6 Crop year. Crop year means the 12-month period beginning October 1 of each year and ending September 30 of the following year....

  12. 7 CFR 915.6 - Fiscal year.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Fiscal year. 915.6 Section 915.6 Agriculture... Regulating Handling Definitions § 915.6 Fiscal year. Fiscal year means the twelve-month period ending March 31 of each year....

  13. 7 CFR 915.6 - Fiscal year.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal year. 915.6 Section 915.6 Agriculture... Regulating Handling Definitions § 915.6 Fiscal year. Fiscal year means the twelve-month period ending March 31 of each year....

  14. 7 CFR 63.6 - Fiscal year.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Fiscal year. 63.6 Section 63.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections... CENTER General Provisions Definitions § 63.6 Fiscal year. Fiscal year means a calendar year or any...

  15. 7 CFR 987.6 - Crop year.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Crop year. 987.6 Section 987.6 Agriculture Regulations... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.6 Crop year. Crop year means the 12-month period beginning October 1 of each year and ending September 30 of the following year....

  16. 7 CFR 915.6 - Fiscal year.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Fiscal year. 915.6 Section 915.6 Agriculture... Regulating Handling Definitions § 915.6 Fiscal year. Fiscal year means the twelve-month period ending March 31 of each year....

  17. 7 CFR 987.6 - Crop year.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Crop year. 987.6 Section 987.6 Agriculture Regulations... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.6 Crop year. Crop year means the 12-month period beginning October 1 of each year and ending September 30 of the following year....

  18. 7 CFR 987.6 - Crop year.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Crop year. 987.6 Section 987.6 Agriculture Regulations... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.6 Crop year. Crop year means the 12-month period beginning October 1 of each year and ending September 30 of the following year....

  19. 7 CFR 1000.6 - Supply plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Supply plant. 1000.6 Section 1000.6 Agriculture... Definitions § 1000.6 Supply plant. Supply plant means a plant approved by a duly constituted regulatory agency... diverts fluid milk products to other plants or manufactures dairy products on its premises....

  20. 7 CFR 1000.6 - Supply plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Supply plant. 1000.6 Section 1000.6 Agriculture... Definitions § 1000.6 Supply plant. Supply plant means a plant approved by a duly constituted regulatory agency... diverts fluid milk products to other plants or manufactures dairy products on its premises....

  1. 7 CFR 1000.6 - Supply plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Supply plant. 1000.6 Section 1000.6 Agriculture... Definitions § 1000.6 Supply plant. Supply plant means a plant approved by a duly constituted regulatory agency... diverts fluid milk products to other plants or manufactures dairy products on its premises....

  2. 7 CFR 1.6 - Aggregating requests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Aggregating requests. 1.6 Section 1.6 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.6 Aggregating requests. When an agency reasonably believes that a requester, or a group of requesters acting in...

  3. 7 CFR 3400.6 - Grant awards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Grant awards. 3400.6 Section 3400.6 Agriculture... RESEARCH GRANTS PROGRAM General § 3400.6 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make research project grants to those responsible,...

  4. 7 CFR 3400.6 - Grant awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Grant awards. 3400.6 Section 3400.6 Agriculture... RESEARCH GRANTS PROGRAM General § 3400.6 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make research project grants to those responsible,...

  5. 7 CFR 3411.6 - Grant awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Grant awards. 3411.6 Section 3411.6 Agriculture... RESEARCH INITIATIVE COMPETITIVE GRANTS PROGRAM General § 3411.6 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make grants to those...

  6. 7 CFR 1000.6 - Supply plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Supply plant. 1000.6 Section 1000.6 Agriculture... Definitions § 1000.6 Supply plant. Supply plant means a plant approved by a duly constituted regulatory agency... diverts fluid milk products to other plants or manufactures dairy products on its premises....

  7. 7 CFR 1000.6 - Supply plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Supply plant. 1000.6 Section 1000.6 Agriculture... Definitions § 1000.6 Supply plant. Supply plant means a plant approved by a duly constituted regulatory agency... diverts fluid milk products to other plants or manufactures dairy products on its premises....

  8. 7 CFR 2812.6 - Title.

    Code of Federal Regulations, 2010 CFR

    2000-01-01

    ... 7 Agriculture 15 2000-01-01 2000-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture-(Continued) OFFICE OF OPERATIONS,DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will...

  9. 7 CFR 2812.6 - Title.

    Code of Federal Regulations, 2010 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS, DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will...

  10. 7 CFR 2812.6 - Title.

    Code of Federal Regulations, 2010 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS, DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will...

  11. 7 CFR 2812.6 - Title.

    Code of Federal Regulations, 2010 CFR

    2009-01-01

    ... 7 Agriculture 15 2009-01-01 2009-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS,DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will...

  12. 7 CFR § 2812.6 - Title.

    Code of Federal Regulations, 2010 CFR

    2016-01-01

    ... 7 Agriculture 15 2016-01-01 2016-01-01 false Title. § 2812.6 Section § 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS, DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will...

  13. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  14. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  15. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  16. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  17. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  18. 7 CFR 1.6 - Aggregating requests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Aggregating requests. 1.6 Section 1.6 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.6 Aggregating requests. When an agency reasonably believes that a requester, or a group of requesters acting in...

  19. 7 CFR 275.6 - Management units.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Management units. 275.6 Section 275.6 Agriculture... FOOD STAMP AND FOOD DISTRIBUTION PROGRAM PERFORMANCE REPORTING SYSTEM Management Evaluation (ME) Reviews § 275.6 Management units. (a) Establishment of management units. For the purpose of ME...

  20. 7 CFR 3415.6 - Grant awards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Grant awards. 3415.6 Section 3415.6 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM General § 3415.6 Grant awards. (a) General. Within...