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Sample records for 5-ht-induced pa contraction

  1. Role of "Aplysia" Cell Adhesion Molecules during 5-HT-Induced Long-Term Functional and Structural Changes

    ERIC Educational Resources Information Center

    Han, Jin-Hee; Lim, Chae-Seok; Lee, Yong-Seok; Kandel, Eric R.; Kaang, Bong-Kiun

    2004-01-01

    We previously reported that five repeated pulses of 5-HT lead to down-regulation of the TM-apCAM isoform at the surface of "Aplysia" sensory neurons (SNs). We here examined whether apCAM down-regulation is required for 5-HT-induced long-term facilitation. We also analyzed the role of the cytoplasmic and extracellular domains by overexpressing…

  2. 42 CFR 434.6 - General requirements for all contracts and subcontracts. P>(a) Contracts. All contracts under...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... contracts and subcontracts.P>(a) Contracts. All contracts under this part must include all of the following: (1) Include provisions that define a sound and complete procurement contract, as required by 45 CFR... subcontracts. P>(a) Contracts. All contracts under this part must include all of the following: 434.6...

  3. Naftopidil inhibits 5-hydroxytryptamine-induced bladder contraction in rats.

    PubMed

    Sakai, Takumi; Kasahara, Ken-ichi; Tomita, Ken-ichi; Ikegaki, Ichiro; Kuriyama, Hiroshi

    2013-01-30

    Naftopidil is an α(1D) and α(1A) subtype-selective α(1)-adrenoceptor antagonist that has been used to treat lower urinary tract symptoms of benign prostatic hyperplasia. In this study, we investigated the effects of naftopidil on 5-hydroxytryptamine (5-HT)-induced rat bladder contraction (10(-8)-10(-4) M). Naftopidil (0.3, 1, and 3 μM) inhibited 5-HT-induced bladder contraction in a concentration-dependent manner. On the other hand, other α(1)-adrenoceptor antagonists, tamsulosin, silodosin or prazosin, did not inhibit 5-HT-induced bladder contraction. The 5-HT-induced bladder contraction was inhibited by both ketanserin and 4-(4-fluoronaphthalen-1-yl)-6-propan-2-ylpyrimidin-2-amine (RS127445), serotonin 5-HT(2A) and 5-HT(2B) receptor antagonists, respectively. In addition, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and α-methyl-5-HT, 5-HT(2A) and 5-HT(2) receptor agonists, respectively, induced bladder contraction. The 5-HT-induced bladder contraction was not inhibited by N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-yl-cyclohexanecarboxamide (WAY-100635), [1-[2[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl-1-methyl-1H-indole-3-carboxylate (GR113808) or (R)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulphonyl]phenol (SB269970), 5-HT(1A), 5-HT(4) and 5-HT(7) receptor antagonists, respectively. Naftopidil inhibited both the 5-HT(2A) and 5-HT(2) receptor agonists-induced bladder contractions. Naftopidil binds to the human 5-HT(2A) and 5-HT(2B) receptors with pKi values of 6.55 and 7.82, respectively. These results suggest that naftopidil inhibits 5-HT-induced bladder contraction via blockade of the 5-HT(2A) and 5-HT(2B) receptors in rats. Furthermore, 5-HT-induced bladder contraction was enhanced in bladder strips obtained from bladder outlet obstructed rats, with this contraction inhibited by naftopidil. The beneficial effects of naftopidil on storage symptoms such as urinary frequency and nocturia in patients with benign

  4. Possible site of action of 2-methylserotonin in inducing relaxation of acetylcholine-induced contraction in the molluscan (Mytilus edulis) smooth muscle.

    PubMed

    Murakami, H; Kizawa, Y; Sano, M; Edamura, N; Maruyama, C; Yamazaki, A

    1992-02-01

    1. The present study investigated the presence of 5-HT3 receptor using 2-methylserotonin (2-Me-5-HT) in the smooth muscle of Mytilus ABRM. 2. 2-Me-5-HT relaxed the acetylcholine-induced contraction in a dose-dependent manner ranging from 10(-6) to 3 x 10(-4) M (pD2 = 5.55 +/- 0.32). 3. 2-Me-5-HT-induced relaxation was antagonized by 3 x 10(-5) M ketanserin in a competitive manner (pA2 = 5.14 +/- 0.1), but not by cypropheptadine, mianserin, MDL 72222 or ICS 205-930 at a concentration of 3 x 10(-5) M. 4. 2-Me-5-HT (3 x 10(-4) M) did not alter the content of cyclic AMP and cyclic GMP in the ABRM. 5. These findings suggested that the 2-Me-5-HT-induced relaxation was mediated through 5-HT2-like receptors and was not linked to cyclic AMP or GMP systems, and, further, that 5-HT3 receptor subtype was not present in the ABRM.

  5. Distribution of serotonin 5-HT1A-binding sites in the brainstem and the hypothalamus, and their roles in 5-HT-induced sleep and ingestive behaviors in rock pigeons (Columba livia).

    PubMed

    dos Santos, Tiago Souza; Krüger, Jéssica; Melleu, Fernando Falkenburger; Herold, Christina; Zilles, Karl; Poli, Anicleto; Güntürkün, Onur; Marino-Neto, José

    2015-12-15

    Serotonin 1A receptors (5-HT1ARs), which are widely distributed in the mammalian brain, participate in cognitive and emotional functions. In birds, 5-HT1ARs are expressed in prosencephalic areas involved in visual and cognitive functions. Diverse evidence supports 5-HT1AR-mediated 5-HT-induced ingestive and sleep behaviors in birds. Here, we describe the distribution of 5-HT1ARs in the hypothalamus and brainstem of birds, analyze their potential roles in sleep and ingestive behaviors, and attempt to determine the involvement of auto-/hetero-5-HT1ARs in these behaviors. In 6 pigeons, the anatomical distribution of [(3)H]8-OH-DPAT binding in the rostral brainstem and hypothalamus was examined. Ingestive/sleep behaviors were recorded (1h) in 16 pigeons pretreated with MM77 (a heterosynaptic 5-HT1AR antagonist; 23 or 69 nmol) for 20 min, followed by intracerebroventricular ICV injection of 5-HT (N:8; 150 nmol), 8-OH-DPAT (DPAT, a 5-HT1A,7R agonist, 30 nmol N:8) or vehicle. 5-HT- and DPAT-induced sleep and ingestive behaviors, brainstem 5-HT neuronal density and brain 5-HT content were examined in 12 pigeons, pretreated by ICV with the 5-HT neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) or vehicle (N:6/group). The distribution of brainstem and diencephalic c-Fos immunoreactivity after ICV injection of 5-HT, DPAT or vehicle (N:5/group) into birds provided with or denied access to water is also described. 5-HT1ARs are concentrated in the brainstem 5-HTergic areas and throughout the periventricular hypothalamus, preoptic nuclei and circumventricular organs. 5-HT and DPAT produced a complex c-Fos expression pattern in the 5-HT1AR-enriched preoptic hypothalamus and the circumventricular organs, which are related to drinking and sleep regulation, but modestly affected c-Fos expression in 5-HTergic neurons. The 5-HT-induced ingestivebehaviors and the 5-HT- and DPAT-induced sleep behaviors were reduced by MM77 pretreatment. 5,7-DHT increased sleep per se, decreased tryptophan

  6. Doxazosin selectively potentiates contraction to serotonin via 5-HT₂A receptors in longitudinal muscle strips of the rabbit gastric body.

    PubMed

    Zhao, Yan; Cao, Xue-Bin; Ren, Lei-Ming

    2014-03-01

    The aims of this study were to examine the effects of doxazosin on contractile responses to 5-hydroxytryptamine (5-HT), carbachol, and histamine, and to compare them with those of prazosin, alfuzosin, and terazosin, and then characterize a pharmacological profile of the 5-HT-induced contractile response using preparations of isolated longitudinal muscle strips from the rabbit gastric body. The results from these preparations showed that the contraction response to 5-HT, but not to carbachol or histamine, was found to be dose-dependently potentiated by doxazosin and its enantiomers. The specific potentiation effect on 5-HT was not observed in the preparations that were treated with prazosin, terazosin, or alfuzosin. The contractile response to 5-HT and its potentiation by doxazosin were not affected by treatment with phenoxybenzamine. However, 5-HT-induced contraction was competitively antagonized by nefazodone (with pA₂ value of 8.64 ± 0.17), and was almost completely inhibited by treatment with indomethacin. In conclusion, doxazosin, but not prazosin, alfuzosin, or terazosin, selectively potentiates 5-HT-induced contraction in the rabbit gastric body strips via an α₁-adrenoceptor-independent mechanism, without chiral recognition of its enantiomers. Additionally, the contraction to 5-HT was found to be mediated via 5-HT(₂) receptors, and was similar to PGs synthesis in the preparations.

  7. Contractions

    MedlinePlus

    ... feel tightening of your uterus muscles at irregular intervals or a squeezing sensation in your lower abdomen ... beginning of childbirth. These contractions come at regular intervals, usually move from the back to the lower ...

  8. Inhibition of native 5-HT3 receptor-evoked contractions in guinea pig and mouse ileum by antimalarial drugs.

    PubMed

    Kelley, Stephen P; Walsh, Jacqueline; Kelly, Mark C; Muhdar, Simerjyot; Adel-Aziz, Mohammed; Barrett, Iain D; Wildman, Scott S

    2014-09-01

    Quinine, chloroquine and mefloquine are commonly used to treat malaria, however, with associated gastrointestinal (GI) side-effects. These drugs act as antagonists at recombinant 5-HT3 receptors and modulate gut peristalsis. These gastrointestinal side effects may be the result of antagonism at intestinal 5-HT3 receptors. Ileum from male C57BL/6 mice and guinea pigs was mounted longitudinally in organ baths. The concentration-response curves for 5-HT and the selective 5-HT3 agonist 2-Me-5-HT were obtained with 5-HT (pEC50 = 7.57 ± 0.33, 12) more potent (P = 0.004) than 2-Me-5-HT (pEC50 = 5.45 ± 0.58, n = 5) in mouse ileum. There was no difference in potency of 5-HT (pEC50 = 5.42 ± 0.15, n = 8) and 2-Me-5-HT (pIC50 = 5.01 ± 0.55, n = 11) in guinea pig ileum (P > 0.05). Quinine, chloroquine or mefloquine was applied for 10 min and inhibitions prior to submaximal agonist application. In mouse ileum, quinine, chloroquine and mefloquine antagonised 5-HT-induced contractions (pIC50 = 4.9 ± 0.17, n = 7; 4.76 ± 0.14, n = 5; 6.21 ± 0.2, n = 4, correspondingly) with mefloquine most potent (P < 0.05). Quinine, chloroquine and mefloquine antagonised 2-me-5-HT-induced contractions (pIC50 = 6.35 ± 0.11, n = 8; 4.64 ± 0.2, n = 7; 5.11 ± 0.22, n = 6, correspondingly) with quinine most potent (P < 0.05). In guinea-pig ileum, quinine, chloroquine and mefloquine antagonised 5-HT-induced contractions (pIC50 = 5.02 ± 0.15, n = 6; 4.54 ± 0.1, n = 7; 5.32 ± 0.13, n = 5) and 2-me-5-HT-induced contractions (pIC50 = 4.62 ± 0.25, n = 5; 4.56 ± 0.14, n = 6; 5.67 ± 0.12, n = 4) with chloroquine least potent against 5-HT and mefloquine most potent against 2-me-5-HT (P < 0.05). These results support previous studies identifying anti-malarial drugs as antagonists at recombinant 5-HT3 receptors and may also demonstrate the ability of these drugs to influence native 5-HT3 receptor-evoked contractile responses which may account for their associated GI side-effects. PMID:24886883

  9. Mechanisms of 5-hydroxytryptamine-induced contraction of isolated rat intrapulmonary bronchi.

    PubMed

    Szarek, J L; Zhang, J Z; Gruetter, C A

    1995-12-01

    Previous studies in our laboratory and others suggested that activation of 5-HT2 receptors mediates 5-hydroxytryptamine (5-HT)-induced contraction of airway smooth muscle and that this response is dependent in part on endogenous acetylcholine (ACh). The purpose of the present study was to confirm a role for 5-HT2 receptors and endogenous ACh in 5-HT-induced contraction of rat bronchi. In this study, we examined the effects of 5-HT2 receptor antagonists (ketanserin and LY53857), acetylcholinesterase inhibitors (physostigmine and neostigmine), and a muscarinic receptor alkylating agent [propylbenzilylcholine mustard (PBCM)] on contractile responses evoked by 5-HT and the 5-HT2 receptor agonist, alpha-methyl-5-hydroxytryptamine (alpha-Me-5-HT). Concentration-response curves generated in isolated rat intrapulmonary bronchi in response to 5-HT and alpha-Me-5-HT were superimposable. Inhibition of acetylcholinesterase by physostigmine or neostigmine potentiated contractile responses elicited by 5-HT and alpha-Me-5-HT. Alkylation of muscarinic receptors with PBCM decreased maximal responses elicited by 5-HT or alpha-Me-5-HT in a concentration-dependent manner. Maximum contraction attained with exogenous ACh was decreased by PBCM in a concentration-dependent manner and, at the highest concentration evaluated, ACh-induced contractions were abolished. 5-Hydroxytryptamine-induced contraction was inhibited competitively by low concentrations of the 5-HT2-receptor selective antagonist, ketanserin; higher concentrations abolished contractile responses to the amine. The inhibition of 5-HT-induced contractile responses by another 5-HT2-receptor selective antagonist, LY53857, was non-competitive in nature. Together, the results suggest that 5-HT contracts rat airways directly by activating 5-HT2 receptors located on airway smooth muscle and indirectly by activation of 5-HT2 receptors on parasympathetic nerve endings to cause release of ACh. The potential physiological implication of

  10. Participation of 5-HT1-like and 5-HT2A receptors in the contraction of human temporal artery by 5-hydroxytryptamine and related drugs.

    PubMed Central

    Verheggen, R.; Freudenthaler, S.; Meyer-Dulheuer, F.; Kaumann, A. J.

    1996-01-01

    1. We investigated the hypothesis that, as in some other large human arteries, 5-HT-induced contraction of the temporal artery is mediated through two co-existing receptor populations, 5-HT1-like- and 5-HT2A. Temporal arterial segments were obtained from patients undergoing brain surgery and rings prepared set up to contract with 5-HT and related agents. Fractions of maximal 5-HT responses mediated through 5-HT1-like and 5-HT2A receptors, f1 and f2 = 1-f1, were estimated by use of the 5-HT2A-selective antagonist ketanserin. 2. In rings with intact endothelium 5-HT evoked contractions with a -log EC50, M of 7.0. Ketanserin (10-1000 nM) antagonized part of the 5-HT-induced contractions. Ketanserin-resistant components of 5-HT-induced contractions were found with -log EC50, M of 6.9 and f1 of 0.17 (100 nM ketanserin) and -log EC50, M of 6.4 and f1 of 0.20 (1000 nM ketanserin). 3. In rings with endothelial function attenuated by enzymatic treatment, 5-HT caused contractions with a -log EC50, M of 7.2 that were partially blocked by ketanserin. Ketanserin-resistant components of 5-HT-induced contractions were found with -log EC50, M 7.4 and f1 of 0.16 (100 nM ketanserin) and -log EC50, M of 7.5 and f1 of 0.14 (1000 nM ketanserin). 4. The ketanserin-resistant component of 5-HT-evoked contraction was blocked by methiothepin (100-1000 nM) consistent with mediation through 5-HT1-like receptors. 5. In rings with intact endothelium the 5-HT1-like-selective agonist, sumatriptan, caused small contractions with a -log EC50, M of 6.5 and intrinsic activity of 0.21 with respect to 5-HT that were resistant to blockade by 1000 nM ketanserin but antagonized by 100 nM methiothepin. 6. In rings with intact endothelium the 5-HT2A receptor partial agonist SK&F 103829 (2,3,4,5-tetrahydro-8[methyl sulphonyl]-1H3-benzazepin-7-ol methensulphonate) contracted rings with a -log EC50, M of 5.0 and an intrinsic activity of 0.49 with respect to 5-HT; the effects were antagonized by ketanserin 1000

  11. Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase.

    PubMed

    Sung, Dong Jun; Noh, Hyun Ju; Kim, Jae Gon; Park, Sang Woong; Kim, Bokyung; Cho, Hana; Bae, Young Min

    2013-01-01

    Serotonin (5-hydroxytryptamine (5-HT)) is a neurotransmitter that regulates a variety of functions in the nervous, gastrointestinal and cardiovascular systems. Despite such importance, 5-HT signaling pathways are not entirely clear. We demonstrated previously that 4-aminopyridine (4-AP)-sensitive voltage-gated K(+) (Kv) channels determine the resting membrane potential of arterial smooth muscle cells and that the Kv channels are inhibited by 5-HT, which depolarizes the membranes. Therefore, we hypothesized that 5-HT contracts arteries by inhibiting Kv channels. Here we studied 5-HT signaling and the detailed role of Kv currents in rat mesenteric arteries using patch-clamp and isometric tension measurements. Our data showed that inhibiting 4-AP-sensitive Kv channels contracted arterial rings, whereas inhibiting Ca(2+)-activated K(+), inward rectifier K(+) and ATP-sensitive K(+) channels had little effect on arterial contraction, indicating a central role of Kv channels in the regulation of resting arterial tone. 5-HT-induced arterial contraction decreased significantly in the presence of high KCl or the voltage-gated Ca(2+) channel (VGCC) inhibitor nifedipine, indicating that membrane depolarization and the consequent activation of VGCCs mediate the 5-HT-induced vasoconstriction. The effects of 5-HT on Kv currents and arterial contraction were markedly prevented by the 5-HT2A receptor antagonists ketanserin and spiperone. Consistently, α-methyl 5-HT, a 5-HT2 receptor agonist, mimicked the 5-HT action on Kv channels. Pretreatment with a Src tyrosine kinase inhibitor, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine, prevented both the 5-HT-mediated vasoconstriction and Kv current inhibition. Our data suggest that 4-AP-sensitive Kv channels are the primary regulator of the resting tone in rat mesenteric arteries. 5-HT constricts the arteries by inhibiting Kv channels via the 5-HT2A receptor and Src tyrosine kinase pathway. PMID:24336234

  12. A role for inositol 1,4,5-trisphosphate in the initiation of agonist-induced contractions of dog tracheal smooth muscle.

    PubMed

    Hashimoto, T; Hirata, M; Ito, Y

    1985-09-01

    cimetidine (10-5M), nor prostaglandin F2 alpha. (PGF2 alpha. 1O-7 M) showed any effect on the contents of PI-P2 or PA in the lipid fraction of the smooth muscle cells. 8 These results indicate that in muscle cells of the dog trachea, Ins-P3 may play the role ofintracellular second messenger in the initiation of ACh or 5-HT-induced contraction, but not in the case of histamine or PGF2 alpha-induced contraction.

  13. Characterization of the 5-hydroxytryptamine receptors mediating contraction in the pig isolated intravesical ureter

    PubMed Central

    Hernández, Medardo; Barahona, María Victoria; Simonsen, Ulf; Recio, Paz; Rivera, Luis; Martínez, Ana Cristina; García-Sacristán, Albino; Orensanz, Luis M; Prieto, Dolores

    2003-01-01

    This study was designed to investigate the effect of 5-hydroxytryptamine (5-HT) and to characterize the 5-HT receptors involved in 5-HT responses in the pig intravesical ureter. 5-HT (0.01–10 μM) concentration-dependently increased the tone of intravesical ureteral strips, whereas the increases in phasic contractions were concentration-independent. The 5-HT2 receptor agonist α-methyl 5-HT, mimicked the effect on tone whereas weak or no response was obtained with 5-CT, 8-OH-DPAT, m-chlorophenylbiguanide and RS 67333, 5-HT1, 5-HT1A, 5-HT3 and 5-HT4 receptor agonists, respectively. 5-HT did not induce relaxation of U46619-contracted ureteral preparations. Pargyline (100 μM), a monoaminooxidase A/B activity inhibitor, produced leftward displacements of the concentration-response curves for 5-HT. 5-HT-induced tone was reduced by the 5-HT2 and 5-HT2A receptor antagonists ritanserine (0.1 μM) and spiperone (0.2 μM), respectively. However, 5-HT contraction was not antagonized by cyanopindolol (2 μM), SDZ–SER 082 (1 μM), Y-25130 (1 μM) and GR 113808 (0.1 μM), which are respectively, 5-HT1A/1B, 5-HT2B/2C, 5-HT3, and 5-HT4 selective receptor antagonists. Removal of the urothelium did not modify 5-HT-induced contractions. Blockade of neuronal voltage-activated sodium channels, α-adrenergic receptors and adrenergic neurotransmission with tetrodotoxin (1 μM), phentolamine (0.3 μM) and guanethidine (10 μM), respectively, reduced the contractions to 5-HT. However, physostigmine (1 μM), atropine (0.1 μM) and suramin (30 μM), inhibitors of cholinesterase activity, muscarinic- and purinergic P2-receptors, respectively, failed to modify the contractions to 5-HT. These results suggest that 5-HT increases the tone of the pig intravesical ureter through 5-HT2A receptors located at the smooth muscle. Part of the 5-HT contraction is indirectly mediated via noradrenaline release from sympathetic nerves. PMID:12522083

  14. Phosphatidic acid-induced contraction in guinea-pig taenia coli.

    PubMed

    Ohata, H; Momose, K

    1990-06-01

    Natural phosphatidic acid from egg yolk lecithin (PA) caused a sustained contraction in guinea-pig taenia coli. The contractile response to PA was concentration-dependent (10(-6)-10(-4) M) in the normal medium and the maximal response to PA was about 20% of the response to carbachol (CCh) at 10(-6) M. Phospholipase D mimicked PA-induced contraction. This result suggests that increase in endogenous PA can induce contraction. The PA-induced contraction was not inhibited by atropine (10(-6) M). The contraction was more dependent on concentration of extracellular Ca2+ than CCh-induced contraction. PA increased 45Ca2+ uptake into the tissue. These results suggest that the PA-induced contraction results from increase in Ca2+ influx across plasma membranes, but not release of Ca2+ from intracellular stores in guinea-pig taenia coli. The PA-induced contraction was inhibited to 42% of the control response by propyl gallate (0.2 mM), a combined inhibitor of cyclooxygenase and lipoxygenase. This result indicates that a portion of the contraction is related to release of arachidonic acid and its metabolites, and the other portions are based on direct action of PA. These results suggest a possibility that increased PA by agonist stimulation is related to the following extracellular Ca2(+)-dependent contraction.

  15. 32 CFR 701.123 - PA fees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false PA fees. 701.123 Section 701.123 National... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.123 PA fees. The PA fee schedule is only applicable... PA system of record. DON activities receiving requests under PA, FOIA, or PA/FOIA shall only...

  16. PaR-PaR Laboratory Automation Platform

    SciTech Connect

    Linshiz, G; Stawski, N; Poust, S; Bi, CH; Keasling, JD; Hilson, NJ

    2013-05-01

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

  17. PaR-PaR laboratory automation platform.

    PubMed

    Linshiz, Gregory; Stawski, Nina; Poust, Sean; Bi, Changhao; Keasling, Jay D; Hillson, Nathan J

    2013-05-17

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

  18. 48 CFR 1219.812 - Contract administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Program) 1219.812 Contract administration. (d) All direct 8(a) awards made pursuant to the PA are subject to 15 U.S.C. 637(a) (21). These contracts contain the clause at (TAR) 48 CFR 1252.219-71, Section...

  19. Architect's Contract.

    ERIC Educational Resources Information Center

    Ohio State Board of Education, Columbus.

    An actual contract form used for architectural services is presented. Fees, duties, and services are included. Services are listed in the following phases--(1) schematic design, (2) design development, (3) contract document, and (4) construction. Extra services are listed, and owner's responsibility with regard to cost estimates is given.…

  20. Performance Contracting.

    ERIC Educational Resources Information Center

    Allen, Tom

    The management team at Minooka (Illinois) School District 201 is actively pursuing school improvement measures by establishing Performance Contracts to increase productivity. The format of the Performance Contract highlights yearly short-term and long-term goals, which are presented in the form of Job Improvement Targets stating the goal itself, a…

  1. Student Contracts.

    ERIC Educational Resources Information Center

    Aldridge, Hal

    1971-01-01

    Discussion of the nature of student-teacher contracts pertaining to academic work to be performed by the student and evaluated by the teacher covers a wide range of related issues in this article. The nature of contracts, evaluation procedures, instructional materials, community attitudes, and the individualization of instruction are commented on…

  2. Contract sanctity

    SciTech Connect

    Seeley, R.S.

    1995-10-01

    Increased competition and the pressure to keep rates low is driving utilities and independent power producers alike to consider more options to keep costs down. While an important strategy for them, the results are creating some conflicts. The April 12, 1995 Federal Energy Regulatory Commission (FERC) decision against New York State Electric & Gas (NYSEG) attempt to breach contracts with two independent power producers, observers say, is one of the most important decisions on contract disputes between independents and utilities. It reveals the complex issues and compelling arguments on both sides. It opens the question of utilities` ability to pay, and the future direction of independent power. The conflicts create a problem for utilities and independents alike.

  3. 49 CFR 372.211 - Pittsburgh, PA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Pittsburgh, PA. 372.211 Section 372.211... ZONES, AND TERMINAL AREAS Commercial Zones § 372.211 Pittsburgh, PA. The zone adjacent to, and... and is comprised of all points as follows: (a) The municipality of Pittsburgh, Pa., itself; (b)...

  4. 32 CFR 701.113 - PA exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false PA exemptions. 701.113 Section 701.113 National... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.113 PA exemptions. (a) Exempt systems of records. 5....navy.mil. (b) Exemption rule. No PA exemption may be established for a system of records until...

  5. Contracting and Higher Education.

    ERIC Educational Resources Information Center

    Ferris, James M.

    1991-01-01

    The potential gains in efficiency of three types of contracts in college administration are contrasted. Contract types include explicit contracts in the budgeting process between the state and higher education institutions; institutional contracting for inputs; and interinstitutional contracting. The tradeoff between production cost savings and…

  6. The GMENAC report and the PA profession.

    PubMed

    Cawley, James F

    2016-10-01

    The 1980 report of the Graduate Medical Education National Advisory Committee (GMENAC) predicted a surplus of physicians by 1990 and 2000. The report appeared to have a depressing effect on the growth of the PA profession in the early 1980s; in the 9 years following its release, no new PA programs were started and a number of existing programs closed. The GMENAC forecast proved to be inaccurate and the PA profession saw significant program growth in the 1990s and beyond. A lesson of GMENAC is that accurately predicting health workforce supply and demand is difficult. PMID:27685515

  7. Cluster CAA Module for PaPCo

    NASA Astrophysics Data System (ADS)

    Faden, J.; Åsnes, A.; Friedel, R.; Taylor, M.; McCaffrey, S.; Perry, C.; Goldstein, M. L.

    A PaPCo module for visualization of data from the CAA has been developed. This module retrieves data from the CAA web interface, and allows for discovery and plotting of new datasets. PaPCo is modular, open source IDL software that uses plug-in modules to bring new datasets on to a stack of time series plots (www.papco.org). PaPCo includes modules for plotting data from Cluster/PEACE and Cluster/RAPID, CDA Web data which includes Cluster Prime Parameters, and various modules from CRRES, POLAR, GPS, and many other spacecraft. The Cluster CAA module is presented, as well as a brief description of PaPCo's use and installation procedure.

  8. Oxidation of gas-phase protactinium ions, Pa+ and Pa2+: formation and properties of PaO2(2+)(g), protactinyl.

    PubMed

    Santos, Marta; de Matos, António Pires; Marçalo, Joaquim; Gibson, John K; Haire, Richard G; Tyagi, Rajni; Pitzer, Russell M

    2006-05-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N(2)O to the relatively weak CH(2)O-all oxidized Pa(+) to PaO(+) and PaO(+) to PaO(2)(+). On the basis of experimental observations, it was established that D[Pa(+)-O] and D[OPa(+)-O] > or = 751 kJ mol(-1). Estimates for D[Pa(+)-O], D[OPa(+)-O], IE[PaO], and IE[PaO(2)] were also obtained. The seven oxidants reacted with Pa(2+) to produce PaO(2+), indicating that D[Pa(2+)-O] > or = 751 kJ mol(-1). A particularly notable finding was the oxidation of PaO(2+) by N(2)O to PaO(2)(2+), a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO(2)(2+) suggested the protactinyl connectivity, {O-Pa-O}(2+). The experimentally determined IE[PaO(2)(+)] approximately 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO(2)(+) and PaO(2)(2+). These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial "6p hole" in the case of protactinyl. It was found that PaO(2)(2+) catalyzes the oxidation of CO by N(2)O-such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO(2)(2+) is capable of activating H(2) to form the stable PaO(2)H(2+) ion.

  9. Oxidation of gas-phase protactinium ions, Pa+ and Pa2+: formation and properties of PaO2(2+)(g), protactinyl.

    PubMed

    Santos, Marta; de Matos, António Pires; Marçalo, Joaquim; Gibson, John K; Haire, Richard G; Tyagi, Rajni; Pitzer, Russell M

    2006-05-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N(2)O to the relatively weak CH(2)O-all oxidized Pa(+) to PaO(+) and PaO(+) to PaO(2)(+). On the basis of experimental observations, it was established that D[Pa(+)-O] and D[OPa(+)-O] > or = 751 kJ mol(-1). Estimates for D[Pa(+)-O], D[OPa(+)-O], IE[PaO], and IE[PaO(2)] were also obtained. The seven oxidants reacted with Pa(2+) to produce PaO(2+), indicating that D[Pa(2+)-O] > or = 751 kJ mol(-1). A particularly notable finding was the oxidation of PaO(2+) by N(2)O to PaO(2)(2+), a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO(2)(2+) suggested the protactinyl connectivity, {O-Pa-O}(2+). The experimentally determined IE[PaO(2)(+)] approximately 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO(2)(+) and PaO(2)(2+). These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial "6p hole" in the case of protactinyl. It was found that PaO(2)(2+) catalyzes the oxidation of CO by N(2)O-such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO(2)(2+) is capable of activating H(2) to form the stable PaO(2)H(2+) ion. PMID:16640369

  10. Functional Characterization of Phalaenopsis aphrodite Flowering Genes PaFT1 and PaFD.

    PubMed

    Jang, Seonghoe; Choi, Sang-Chul; Li, Hsing-Yi; An, Gynheung; Schmelzer, Elmon

    2015-01-01

    We show that the key flowering regulators encoded by Phalaenopsis aphrodite FLOWERING LOCUS T1 (PaFT1) and PaFD share high sequence homologies to these from long-day flowering Arabidopsis and short-day flowering rice. Interestingly, PaFT1 is specifically up-regulated during flowering inductive cooling treatment but is not subjected to control by photoperiod in P. aphrodite. Phloem or shoot apex-specific expression of PaFT1 restores the late flowering of Arabidopsis ft mutants. Moreover, PaFT1 can suppress the delayed flowering caused by SHORT VEGATATIVE PHASE (SVP) overexpression as well as an active FRIGIDA (FRI) allele, indicating the functional conservation of flowering regulatory circuit in different plant species. PaFT1 promoter:GUS in Arabidopsis showed similar staining pattern to that of Arabidopsis FT in the leaves and guard cells but different in the shoot apex. A genomic clone or heat shock-inducible expression of PaFT1 is sufficient to the partial complementation of the ft mutants. Remarkably, ectopic PaFT1 expression also triggers precocious heading in rice. To further demonstrate the functional conservation of the flowering regulators, we show that PaFD, a bZIP transcription factor involved in flowering promotion, interacts with PaFT1, and PaFD partially complemented Arabidopsis fd mutants. Transgenic rice expressing PaFD also flowered early with increased expression of rice homologues of APETALA1 (AP1). Consistently, PaFT1 knock-down Phalaenopsis plants generated by virus-induced gene silencing exhibit delayed spiking. These studies suggest functional conservation of FT and FD genes, which may have evolved and integrated into distinct regulatory circuits in monopodial orchids, Arabidopsis and rice that promote flowering under their own inductive conditions. PMID:26317412

  11. Functional Characterization of Phalaenopsis aphrodite Flowering Genes PaFT1 and PaFD

    PubMed Central

    Jang, Seonghoe; Choi, Sang-Chul; Li, Hsing-Yi; An, Gynheung; Schmelzer, Elmon

    2015-01-01

    We show that the key flowering regulators encoded by Phalaenopsis aphrodite FLOWERING LOCUS T1 (PaFT1) and PaFD share high sequence homologies to these from long-day flowering Arabidopsis and short-day flowering rice. Interestingly, PaFT1 is specifically up-regulated during flowering inductive cooling treatment but is not subjected to control by photoperiod in P. aphrodite. Phloem or shoot apex-specific expression of PaFT1 restores the late flowering of Arabidopsis ft mutants. Moreover, PaFT1 can suppress the delayed flowering caused by SHORT VEGATATIVE PHASE (SVP) overexpression as well as an active FRIGIDA (FRI) allele, indicating the functional conservation of flowering regulatory circuit in different plant species. PaFT1 promoter:GUS in Arabidopsis showed similar staining pattern to that of Arabidopsis FT in the leaves and guard cells but different in the shoot apex. A genomic clone or heat shock-inducible expression of PaFT1 is sufficient to the partial complementation of the ft mutants. Remarkably, ectopic PaFT1 expression also triggers precocious heading in rice. To further demonstrate the functional conservation of the flowering regulators, we show that PaFD, a bZIP transcription factor involved in flowering promotion, interacts with PaFT1, and PaFD partially complemented Arabidopsis fd mutants. Transgenic rice expressing PaFD also flowered early with increased expression of rice homologues of APETALA1 (AP1). Consistently, PaFT1 knock-down Phalaenopsis plants generated by virus-induced gene silencing exhibit delayed spiking. These studies suggest functional conservation of FT and FD genes, which may have evolved and integrated into distinct regulatory circuits in monopodial orchids, Arabidopsis and rice that promote flowering under their own inductive conditions. PMID:26317412

  12. 231Pa and 233Pa Neutron-Induced Fission Data Analysis

    SciTech Connect

    Maslov, V.M.; Tetereva, N.A.; Baba, M.; Hasegawa, A.; Kornilov, N.V.; Kagalenko, A.B.

    2005-05-24

    The 231Pa and 233Pa neutron-induced fission cross-section database is analyzed within the Hauser-Feshbach approach. The consistency of neutron-induced fission cross-section data and data extracted from transfer reactions is investigated. The fission probabilities of Pa, fissioning in 231,233Pa(n,nf) reactions, are defined by fitting (3He,d) or (3He,t) transfer-reaction data. The present estimate of the 233Pa(n,f) fission cross section above the emissive fission threshold is supported by smooth level-density parameter systematics, validated in the case of the 231Pa(n,f) data description up to En =20 MeV.

  13. Reviving Ulysses contracts.

    PubMed

    Spellecy, Ryan

    2003-12-01

    Ulysses contracts have faced paternalism objections since they first were proposed. Since the contracts are designed to override a present request from a legally competent patient in favor of a past request made by that patient, enforcement of these contracts was argued to be unjustifiable strong paternalism. Recent legal developments and new theories of practical reasoning suggest that the discussion of Ulysses contracts should be revived. This paper argues that with a proper understanding of the future-directed planning embodied in Ulysses contracts, the charge of strong paternalism can be answered, and the enforcement of some Ulysses contracts may be justified under the rubric of weak paternalism.

  14. 75 FR 69468 - Metlife Moosic, PA, Metlife Clarks Summit, PA; Notice of Affirmative Determination Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    ... published in the Federal Register on August 2, 2010 (75 FR 45163). The initial investigation resulted in a... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Metlife Moosic, PA, Metlife Clarks Summit, PA; Notice of...

  15. 78 FR 60366 - Pennsylvania Disaster #PA-00064

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00064 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... Application Deadline Date: 06/24/2014. ADDRESSES: Submit completed loan applications to: U.S. Small...

  16. 76 FR 44646 - Pennsylvania Disaster #PA-00040

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... ADMINISTRATION Pennsylvania Disaster PA-00040 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street, SW., Suite 6050, Washington,...

  17. 76 FR 64419 - Pennsylvania Disaster #PA-00045

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... ADMINISTRATION Pennsylvania Disaster PA-00045 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the... Kingsport Road, Fort Worth, TX 76155. FOR FURTHER INFORMATION CONTACT: A. Escobar, Office of...

  18. 78 FR 47814 - Pennsylvania Disaster # PA-00059

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... ADMINISTRATION Pennsylvania Disaster PA-00059 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of PENNSYLVANIA... 76155. FOR FURTHER INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small...

  19. 78 FR 62000 - Pennsylvania Disaster #PA-00065

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-10

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00065 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for...

  20. 76 FR 58327 - Pennsylvania Disaster #PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00044 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the Commonwealth...

  1. 76 FR 30749 - Pennsylvania Disaster #PA-00038

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-26

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00038 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of...

  2. 76 FR 5647 - Pennsylvania Disaster #PA-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-01

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00036 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of...

  3. 75 FR 71486 - Pennsylvania Disaster # PA-00035

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... From the Federal Register Online via the Government Publishing Office ] SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00035 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of...

  4. 75 FR 2165 - Pennsylvania Disaster #PA-00030

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00030 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of...

  5. 77 FR 65044 - Pennsylvania Disaster #PA-00054

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00054 AGENCY: U.S. Small Business Administration. ACTION: Notice SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of...

  6. 76 FR 56861 - Pennsylvania Disaster #PA-00043

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00043 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for...

  7. 75 FR 21371 - Pennsylvania Disaster #PA-00031

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00031 AGENCY: Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for...

  8. 78 FR 45282 - Pennsylvania Disaster #PA-00058

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00058 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of...

  9. 76 FR 58328 - Pennsylvania Disaster #PA-00042

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... From the Federal Register Online via the Government Publishing Office ] SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00042 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the Commonwealth...

  10. 78 FR 4967 - Pennsylvania Disaster #PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00057 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for...

  11. 78 FR 52600 - Pennsylvania Disaster #PA-00063

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00063 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of...

  12. 77 FR 60004 - Pennsylvania Disaster #PA-00053

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00053 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of...

  13. 32 CFR 701.113 - PA exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.113 PA exemptions. (a) Exempt systems of records. 5 U.S.C. 552a authorizes SECNAV to adopt rules designating eligible systems of records as exempt from... responsible for proposing an exemption rule. Exempt systems of records are identified at...

  14. 32 CFR 701.113 - PA exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.113 PA exemptions. (a) Exempt systems of records. 5 U.S.C. 552a authorizes SECNAV to adopt rules designating eligible systems of records as exempt from... responsible for proposing an exemption rule. Exempt systems of records are identified at...

  15. Seepage Model for PA Including Dift Collapse

    SciTech Connect

    G. Li; C. Tsang

    2000-12-20

    The purpose of this Analysis/Model Report (AMR) is to document the predictions and analysis performed using the Seepage Model for Performance Assessment (PA) and the Disturbed Drift Seepage Submodel for both the Topopah Spring middle nonlithophysal and lower lithophysal lithostratigraphic units at Yucca Mountain. These results will be used by PA to develop the probability distribution of water seepage into waste-emplacement drifts at Yucca Mountain, Nevada, as part of the evaluation of the long term performance of the potential repository. This AMR is in accordance with the ''Technical Work Plan for Unsaturated Zone (UZ) Flow and Transport Process Model Report'' (CRWMS M&O 2000 [153447]). This purpose is accomplished by performing numerical simulations with stochastic representations of hydrological properties, using the Seepage Model for PA, and evaluating the effects of an alternative drift geometry representing a partially collapsed drift using the Disturbed Drift Seepage Submodel. Seepage of water into waste-emplacement drifts is considered one of the principal factors having the greatest impact of long-term safety of the repository system (CRWMS M&O 2000 [153225], Table 4-1). This AMR supports the analysis and simulation that are used by PA to develop the probability distribution of water seepage into drift, and is therefore a model of primary (Level 1) importance (AP-3.15Q, ''Managing Technical Product Inputs''). The intended purpose of the Seepage Model for PA is to support: (1) PA; (2) Abstraction of Drift-Scale Seepage; and (3) Unsaturated Zone (UZ) Flow and Transport Process Model Report (PMR). Seepage into drifts is evaluated by applying numerical models with stochastic representations of hydrological properties and performing flow simulations with multiple realizations of the permeability field around the drift. The Seepage Model for PA uses the distribution of permeabilities derived from air injection testing in niches and in the cross drift to

  16. Teaching about Contracts.

    ERIC Educational Resources Information Center

    Froman, Michael; Kosnoff, Kathy

    1978-01-01

    Presents teaching strategies for introducing high school students to contract law. Offers as a case study a contract agreement between pro football players and team owners. Stresses basic elements of contracts (offer, acceptance, consideration, and understanding the bargaining process). Journal available from the American Bar Association, 1155…

  17. The Joy of Contracts.

    ERIC Educational Resources Information Center

    Hegarty, Kevin

    This paper is a practical guide that explains and illustrates contracts between libraries and vendors for computerized circulation systems. It describes the elements of a typical contract to include the equipment and services that should be specified in the contract and establishes scheduling and acceptance testing needs. Included in a contract…

  18. Contracting for Services.

    ERIC Educational Resources Information Center

    Jenkins, Robin E.; Nord, Roy

    1982-01-01

    The major steps a college should undertake in contracting for services, including the initial determination as to whether or not contracting is the best way to provide a particular service, are described. Three general activities that apply to decisions about contracting in most circumstances are: investigating service characteristics; identifying…

  19. Russian Teaching Contracts.

    ERIC Educational Resources Information Center

    Stevens, Betsy

    2000-01-01

    Analyzes two Russian teaching contracts, rhetorically comparing purpose and audience, culture, gender, and the role of the individual versus the state. Uses anecdotal episodes as a framework for examining Russian culture and analyzing university teaching contracts, concluding that the contracts are not only brief and factual but also reflect a…

  20. Technical Insights for Saltstone PA Maintenance

    SciTech Connect

    Flach, G.; Sarkar, S.; Mahadevan, S.; Kosson, D.

    2011-07-20

    The Cementitious Barriers Partnership (CBP) is a collaborative program sponsored by the US DOE Office of Waste Processing. The objective of the CBP is to develop a set of computational tools to improve understanding and prediction of the long-term structural, hydraulic, and chemical performance of cementitious barriers and waste forms used in nuclear applications. CBP tools are expected to better characterize and reduce the uncertainties of current methodologies for assessing cementitious barrier performance and increase the consistency and transparency of the assessment process, as the five-year program progresses. In September 2009, entering its second year of funded effort, the CBP sought opportunities to provide near-term tangible support to DOE Performance Assessments (PAs). The Savannah River Saltstone Disposal Facility (SDF) was selected for the initial PA support effort because (1) cementitious waste forms and barriers play a prominent role in the performance of the facility, (2) certain important long-term behaviors of cementitious materials composing the facility are uncertain, (3) review of the SDF PA by external stakeholders is ongoing, and (4) the DOE contractor responsible for the SDF PA is open to receiving technical assistance from the CBP. A review of the current (SRR Closure & Waste Disposal Authority 2009) and prior Saltstone PAs (e.g., Cook et al. 2005) suggested five potential opportunities for improving predictions. The candidate topics considered were (1) concrete degradation from external sulfate attack, (2) impact of atmospheric exposure to concrete and grout before closure, such as accelerated slag and Tc-99 oxidation, (3) mechanistic prediction of geochemical conditions, (4) concrete degradation from rebar corrosion due to carbonation, and (5) early age cracking from drying and/or thermal shrinkage. The candidate topics were down-selected considering the feasibility of addressing each issue within approximately six months, and

  1. {sup 231}Pa photofission cross section

    SciTech Connect

    Soldatov, A.S.; Rudnikov, V.E.; Smirenkin, G.N.

    1995-12-01

    The measurements of the {sup 231}Pa yield and cross section photofission in the energy range 7-9 MeV are presented. These measurements are a continuation of similar measurements performed for the {gamma}-ray energy range 4.8-7 MeV. The entire collection of experimental data which combine the results obtained in the present work and in Ref. 1 was analyzed.

  2. Graphs for Isotopes of 91-Pa (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides a graphic representation of nucleon separation energies and residual interaction parameters for isotopes of the chemical element 91-Pa (Protactinium, atomic number Z = 91).

  3. Indoor radon levels in Cumberland County, PA

    SciTech Connect

    Cohen, B.L.; Nason, R.

    1987-01-01

    Measurements were made of radon levels in 165 randomly selected homes in Cumberland County, PA during Winter 1984-1985. The average and mean levels were found to be 9.1 +/- 0.7 pCi/L and 6.3 +/- 0.5 pCi/L, respectively, many times normally encountered levels. Average and mean radon levels are reported vs. various house characteristics. 4 references, 1 figure, 6 tables.

  4. Sensor Kinase PA4398 Modulates Swarming Motility and Biofilm Formation in Pseudomonas aeruginosa PA14

    PubMed Central

    Strehmel, Janine; Neidig, Anke; Nusser, Michael; Geffers, Robert; Brenner-Weiss, Gerald

    2014-01-01

    Pseudomonas aeruginosa is an opportunistic human pathogen that is able to sense and adapt to numerous environmental stimuli by the use of transcriptional regulators, including two-component regulatory systems. In this study, we demonstrate that the sensor kinase PA4398 is involved in the regulation of swarming motility and biofilm formation in P. aeruginosa PA14. A PA4398− mutant strain was considerably impaired in swarming motility, while biofilm formation was increased by approximately 2-fold. The PA4398− mutant showed no changes in growth rate, rhamnolipid synthesis, or the production of the Pel exopolysaccharide but exhibited levels of the intracellular second messenger cyclic dimeric GMP (c-di-GMP) 50% higher than those in wild-type cells. The role of PA4398 in gene regulation was investigated by comparing the PA4398− mutant to the wild-type strain by using microarray analysis, which demonstrated that 64 genes were up- or downregulated more than 1.5-fold (P < 0.05) under swarming conditions. In addition, more-sensitive real-time PCR studies were performed on genes known to be involved in c-di-GMP metabolism. Among the dysregulated genes were several involved in the synthesis and degradation of c-di-GMP or in the biosynthesis, transport, or function of the iron-scavenging siderophores pyoverdine and pyochelin, in agreement with the swarming phenotype observed. By analyzing additional mutants of selected pyoverdine- and pyochelin-related genes, we were able to show that not only pvdQ but also pvdR, fptA, pchA, pchD, and pchH are essential for the normal swarming behavior of P. aeruginosa PA14 and may also contribute to the swarming-deficient phenotype of the PA4398− mutant in addition to elevated c-di-GMP levels. PMID:25501476

  5. Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility

    PubMed Central

    Huang, Lin; Haratake, Kousuke; Miyahara, Hatsumi; Chiba, Tomoki

    2016-01-01

    Protein degradation mediated by the proteasome is important for the protein homeostasis. Various proteasome activators, such as PA28 and PA200, regulate the proteasome function. Here we show double knockout (dKO) mice of Psme3 and Psme4 (genes for PA28γ and PA200), but not each single knockout mice, are completely infertile in male. The dKO sperms exhibited remarkable defects in motility, although most of them showed normal appearance in morphology. The proteasome activity of the mutant sperms decreased notably, and the sperms were strongly positive with ubiquitin staining. Quantitative analyses of proteins expressed in dKO sperms revealed up-regulation of several proteins involved in oxidative stress response. Furthermore, increased 8-OHdG staining was observed in dKO sperms head, suggesting defective response to oxidative damage. This report verified PA28γ and PA200 play indispensable roles in male fertility, and provides a novel insight into the role of proteasome activators in antioxidant response. PMID:27003159

  6. Sensor kinase PA4398 modulates swarming motility and biofilm formation in Pseudomonas aeruginosa PA14.

    PubMed

    Strehmel, Janine; Neidig, Anke; Nusser, Michael; Geffers, Robert; Brenner-Weiss, Gerald; Overhage, Joerg

    2015-02-01

    Pseudomonas aeruginosa is an opportunistic human pathogen that is able to sense and adapt to numerous environmental stimuli by the use of transcriptional regulators, including two-component regulatory systems. In this study, we demonstrate that the sensor kinase PA4398 is involved in the regulation of swarming motility and biofilm formation in P. aeruginosa PA14. APA4398 mutant strain was considerably impaired in swarming motility, while biofilm formation was increased by approximately 2-fold. The PA4398 mutant showed no changes in growth rate, rhamnolipid synthesis, or the production of the Pel exopolysaccharide but exhibited levels of the intracellular second messenger cyclic dimeric GMP (c-di-GMP) 50% higher than those in wild-type cells. The role of PA4398 in gene regulation was investigated by comparing the PA4398 mutant to the wildtype strain by using microarray analysis, which demonstrated that 64 genes were up- or downregulated more than 1.5-fold (P<0.05) under swarming conditions. In addition, more-sensitive real-time PCR studies were performed on genes known to be involved in c-di-GMP metabolism. Among the dysregulated genes were several involved in the synthesis and degradation of c-di-GMP or in the biosynthesis, transport, or function of the iron-scavenging siderophores pyoverdine and pyochelin, in agreement with the swarming phenotype observed. By analyzing additional mutants of selected pyoverdine- and pyochelin-related genes,we were able to show that not only pvdQ but also pvdR, fptA, pchA, pchD, and pchH are essential for the normal swarming behavior of P. aeruginosa PA14 and may also contribute to the swarming-deficient phenotype of the PA4398 mutant in addition to elevated c-di-GMP levels. PMID:25501476

  7. Issues in physician contracting.

    PubMed

    Fanburg, John D; Leone, Alyson M

    2005-09-01

    Dermatologists will enter into a number of different contracts during their professional careers. It is important that in each agreement they enter, dermatologists reap the benefits that they aspire for and understand the consequences of each provision. This article addresses just a few of the different issues that arise in physician contracting, such as choosing the appropriate form of business entity; the importance of a writing; term and termination of the contract; compensation models; benefits, vacation and other time off included in the contract; malpractice insurance; and restrictive covenants. Each provision should be carefully analyzed to ensure that it will protect the best interests of the dermatologist in that situation. PMID:16202950

  8. AhV_aPA-induced vasoconstriction involves the IP₃Rs-mediated Ca²⁺ releasing.

    PubMed

    Zeng, Fuxing; Zou, Zhisong; Niu, Liwen; Li, Xu; Teng, Maikun

    2013-08-01

    AhV_aPA, the acidic PLA₂ purified from Agkistrodon halys pallas venom, was previously reported to possess a strong enzymatic activity and can remarkably induce a further contractile response on the 60 mM K⁺-induced contraction with an EC₅₀ in 369 nM on mouse thoracic aorta rings. In the present study, we found that the p-bromo-phenacyl-bromide (pBPB), which can completely inhibit the enzymatic activity of AhV_aPA, did not significantly reduce the contractile response on vessel rings induced by AhV_aPA, indicating that the vasoconstrictor effects of AhV_aPA are independent of the enzymatic activity. The inhibitor experiments showed that the contractile response induced by AhV_aPA is mainly attributed to the Ca²⁺ releasing from Ca²⁺ store, especially sarcoplasmic reticulum (SR). Detailed studies showed that the Ca²⁺ release from SR is related to the activation of inositol trisphosphate receptors (IP₃Rs) rather than ryanodine receptors (RyRs). Furthermore, the vasoconstrictor effect could be strongly reduced by pre-incubation with heparin, indicating that the basic amino acid residues on the surface of AhV_aPA may be involved in the interaction between AhV_aPA and the molecular receptors. These findings offer new insights into the functions of snake PLA₂ and provide a novel pathogenesis of A. halys pallas venom.

  9. Role of phosphatidic acid in carbachol-induced contraction in guinea pig Taenia coli.

    PubMed

    Ohata, H; Nobe, K; Momose, K

    1991-01-01

    Carbachol (CCh, 10(-8)-10(-4) M) increased in concentration-dependent manner the mass of phosphatidic acid (PA), but not the mass of diacylglycerol (DG) in the Taenia coli from guinea pig. The increase in the amount of PA caused by CCh was maintained for 20 min. Release of choline from choline phospholipids labeled with [methyl-3H]choline was not changed by CCh. A DG kinase inhibitor, R59022, inhibited the CCh-induced increase in the mass of PA. These results indicate that the increase in the mass of PA by CCh is due to immediate phosphorylation by DG kinase to PA, of the DG produced by phospholipase C (PLC). It is not due to formation of PA by the direct action of phospholipase D. CCh increased 45Ca2+ uptake into the tissue. R59022 inhibited the sustained phase of CCh-induced contraction and 45Ca2+ uptake into the tissue, but only slightly inhibited the initial phase of the CCh-induced contraction. This inhibition by R59022 may result from the inhibitory effect on the CCh-induced increase in PA. These results suggest that CCh activates both PLC and DG kinase and the resultant increase in the mass of PA contributes to the regulation of the sustained phase of CCh-induced contraction which is related to Ca2+ influx.

  10. 48 CFR 235.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... contract type. 235.006 Section 235.006 Federal Acquisition Regulations System DEFENSE ACQUISITION... CONTRACTING 235.006 Contracting methods and contract type. (b)(i) For major defense acquisition programs as... award a fixed-price type contract for a development program effort unless— (1) The level of program...

  11. Performance Contracting Overview.

    ERIC Educational Resources Information Center

    Wohlferd, Gerald H.

    Conclusions reached after three years of performance contracting experience and materials with which to judge the validity of the conclusions are presented in this overview of performance contracting. The conclusions are: (1) commercial firms are no better at teaching children than are public schools; (2) commercial firms expend as much or more…

  12. The New Employment Contract?

    ERIC Educational Resources Information Center

    Levine, David I.

    2002-01-01

    In the classic employment contract, especially at large companies, wages were not strongly responsive to the labor market. Instead, individual companies had distinctive company wage levels and patterns. An exhaustive study of employers and employees in the United States and Japan examined whether the "old employment contract" has been replaced.…

  13. Contracting for Telecommunications Systems.

    ERIC Educational Resources Information Center

    Brautigam, Arthur W.

    1984-01-01

    Reasons for changing telephone systems at colleges and universities and the preparation and evaluation of requests for proposals (RFP) are discussed. The negotiation and monitoring of the contract are also addressed. It is noted that contracting for a new telecommunications system is extremely complex. Reasons for changing systems include cost…

  14. Whither Performance Contracting?

    ERIC Educational Resources Information Center

    Green, Norman S.

    This report describes briefly performance contracts; discusses their shortcomings, pitfalls, and advantages; and gives some insight into the future development of this new concept. Two shortcomings of performance contracting include (1) teaching to the test and (2) board abdication of its responsibility for making final decisions about educational…

  15. Apparatus to measure the vapor pressure of slowly decomposing compounds from 1 Pa to 105 Pa

    PubMed Central

    Berg, Robert F.

    2016-01-01

    This article describes an apparatus and method for measuring vapor pressures in the range from 1 Pa to 105 Pa. Its three distinctive elements are : (1) the static pressure measurements were made with only a small temperature difference between the vapor and the condensed phase, (2) the sample was degassed in situ, and (3) the temperature range extended up to 200 °C. The apparatus was designed to measure metal-organic precursors, which often are toxic, pyrophoric, or unstable. Vapor pressures are presented for naphthalene, ferrocene, diethyl phthalate, and TEMAH (tetrakisethylmethylaminohafnium). Also presented are data for the temperature-dependent decomposition rate of TEMAH. PMID:27274567

  16. Signaling in muscle contraction.

    PubMed

    Kuo, Ivana Y; Ehrlich, Barbara E

    2015-02-02

    Signaling pathways regulate contraction of striated (skeletal and cardiac) and smooth muscle. Although these are similar, there are striking differences in the pathways that can be attributed to the distinct functional roles of the different muscle types. Muscles contract in response to depolarization, activation of G-protein-coupled receptors and other stimuli. The actomyosin fibers responsible for contraction require an increase in the cytosolic levels of calcium, which signaling pathways induce by promoting influx from extracellular sources or release from intracellular stores. Rises in cytosolic calcium stimulate numerous downstream calcium-dependent signaling pathways, which can also regulate contraction. Alterations to the signaling pathways that initiate and sustain contraction and relaxation occur as a consequence of exercise and pathophysiological conditions.

  17. 5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.58. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  18. 7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  19. 6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  20. 4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.73 - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  1. 20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.25. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  2. 75 FR 81469 - Safety Zone; Allegheny River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Allegheny River, Pittsburgh, PA AGENCY... First Night Pittsburgh fireworks display that will occur in the city of Pittsburgh, PA. Under 5 U.S.C... First Night Pittsburgh fireworks display that will occur in the city of Pittsburgh, PA. Background...

  3. 76 FR 28895 - Safety Zone; Ohio River, Sewickley, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ohio River, Sewickley, PA AGENCY: Coast... occur in the city of Sewickley, PA. Under 5 U.S.C. 553(d)(3), the Coast Guard finds that good cause... River, Sewickley, PA. (a) Location. The following area is a safety zone: All waters of the Ohio...

  4. 32 CFR 701.114 - PA enforcement actions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false PA enforcement actions. 701.114 Section 701.114... THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.114 PA enforcement actions. (a... is recommended that the individual first address the issue through the PA coordinator...

  5. 76 FR 27892 - Special Local Regulation; Allegheny River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ..., PA AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a... Pittsburgh, PA. The date of the Venture Outdoors Festival is tied to numerous other events and cannot be... in the city of Pittsburgh, PA. Persons or vessels shall not enter into, depart from, or move...

  6. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false PA self assessments/inspections. 701.124 Section... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.124 PA self assessments... PA program. This serves to identify strengths and weaknesses and to determine training needs...

  7. 76 FR 47993 - Safety Zone; Allegheny River; Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Allegheny River; Pittsburgh, PA AGENCY... that will occur in the city of Pittsburgh, PA on August 6, 2011 (rain date August 7, 2011). Under 5 U.S... occur in the city of Pittsburgh, PA on August 6, 2011 (rain date August 7, 2011). Basis and Purpose...

  8. PaDe - The particle detection program

    NASA Astrophysics Data System (ADS)

    Ott, T.; Drolshagen, E.; Koschny, D.; Poppe, B.

    2016-01-01

    This paper introduces the Particle Detection program PaDe. Its aim is to analyze dust particles in the coma of the Jupiter-family comet 67P/Churyumov-Gerasimenko which were recorded by the two OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) cameras onboard the ESA spacecraft Rosetta, see e.g. Keller et al. (2007). In addition to working with the Rosetta data, the code was modified to work with images from meteors. It was tested with data recorded by the ICCs (Intensified CCD Cameras) of the CILBO-System (Canary Island Long-Baseline Observatory) on the Canary Islands; compare Koschny et al. (2013). This paper presents a new method for the position determination of the observed meteors. The PaDe program was written in Python 3.4. Its original intent is to find the trails of dust particles in space from the OSIRIS images. For that it determines the positions where the trail starts and ends. They were found using a fit following the so-called error function (Andrews, 1998) for the two edges of the profiles. The positions where the intensities fall to the half maximum were found to be the beginning and end of the particle. In the case of meteors, this method can be applied to find the leading edge of the meteor. The proposed method has the potential to increase the accuracy of the position determination of meteors dramatically. Other than the standard method of finding the photometric center, our method is not influenced by any trails or wakes behind the meteor. This paper presents first results of this ongoing work.

  9. 48 CFR 916.307 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 916.307 Contract clauses. (g) Insert the... solicitations and contracts when a cost-reimbursement research and development contract with a State or...

  10. Parrot Bornavirus (PaBV)-2 isolate causes different disease patterns in cockatiels than PaBV-4.

    PubMed

    Piepenbring, Anne K; Enderlein, Dirk; Herzog, Sibylle; Al-Ibadi, Basim; Heffels-Redmann, Ursula; Heckmann, Julia; Lange-Herbst, Hildburg; Herden, Christiane; Lierz, Michael

    2016-01-01

    Psittaciform 1 bornavirus (PaBV) has already been shown to be the aetiologic agent of proventricular dilatation disease, a significant disease of birds. However, the pathogenesis of PaBV infection has not yet been resolved and valid data regarding the pathogenicity of different PaBV species are lacking. Thus, the present study was aimed to characterize the influence of two different PaBV species on the course of disease. Eighteen cockatiels were inoculated intracerebrally (i.c.) or intravenously (i.v.) with a PaBV-2 isolate under the same conditions as in a previous study using PaBV-4. Birds were surveyed and sampled for 33 weeks to analyse the course of infection and disease in comparison to that of PaBV-4. Similar to PaBV-4, PaBV-2 induced a persistent infection with seroconversion (from day 6 p.i. onwards) and shedding of viral RNA (from day 27 p.i. onwards). However, in contrast to PaBV-4, more birds displayed clinical signs and disease progression was more severe. After PaBV-2 infection, 12 birds exhibited clinical signs and 10 birds revealed a dilated proventriculus in necropsy. After PaBV-4 infection only four birds revealed clinical signs and seven birds showed a dilatation of the proventriculus. Clinically, different courses of disease were observed after PaBV-2 infection, mainly affecting the gastrointestinal tract. This had not been detected after PaBV-4 infection where more neurological signs were noted. The results provide evidence for different disease patterns according to different PaBV species, allowing the comparison between the infection with two PaBV species, and thus underlining the role of viral and individual host factors for disease outcome. PMID:27100150

  11. The Case for Performance Contracting.

    ERIC Educational Resources Information Center

    Miller, Sutherland; Wilson, Nancy

    1981-01-01

    Discussed the State of Colorado's introduction of performance contracting into its relationships with community mental health centers. Describes the nature of the contract and its implementation. Particular emphasis is placed on the implications of the contract for program evaluation. (Author)

  12. Quantification of muscle co-contraction using supersonic shear wave imaging.

    PubMed

    Raiteri, Brent J; Hug, François; Cresswell, Andrew G; Lichtwark, Glen A

    2016-02-01

    Muscle stiffness estimated using shear wave elastography can provide an index of individual muscle force during isometric contraction and may therefore be a promising method for quantifying co-contraction. We estimated the shear modulus of the lateral gastrocnemius (LG) muscle using supersonic shear wave imaging and measured its myoelectrical activity using surface electromyography (sEMG) during graded isometric contractions of plantar flexion and dorsiflexion (n=7). During dorsiflexion, the average shear modulus was 26 ± 6 kPa at peak sEMG amplitude, which was significantly less (P=0.02) than that measured at the same sEMG level during plantar flexion (42 ± 10 kPa). The passive tension during contraction was estimated using the passive LG muscle shear modulus during a passive ankle rotation measured at an equivalent ankle angle to that measured during contraction. The passive shear modulus increased significantly (P<0.01) from the plantar flexed position (16 ± 5 kPa) to the dorsiflexed position (26 ± 9 kPa). Once this change in passive tension from joint rotation was accounted for, the average LG muscle shear modulus due to active contraction was significantly greater (P<0.01) during plantar flexion (26 ± 8 kPa) than at sEMG-matched levels of dorsiflexion (0 ± 4 kPa). The negligible shear modulus estimated during isometric dorsiflexion indicates negligible active force contribution by the LG muscle, despite measured sEMG activity of 19% of maximal voluntary plantar flexion contraction. This strongly suggests that the sEMG activity recorded from the LG muscle during isometric dorsiflexion was primarily due to cross-talk. However, it is clear that passive muscle tension changes can contribute to joint torque during isometric dorsiflexion.

  13. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA. 701.120 Section 701.120 National Defense Department of Defense... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or...

  14. 48 CFR 232.617 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Debts 232.617 Contract clause... personnel at civilian schools, colleges, and universities; (B) Basic agreements with telephone companies...

  15. Checking software contracts

    SciTech Connect

    Mitchell, R.; Maung, I.; Howse, J.; Heathcote, T.

    1995-12-31

    In object-oriented software, contracts between classes can be expressed in terms of preconditions, postconditions and invariants. In the programming language Eiffel, contracts can be checked at run-time. Within inheritance hierarchies, contracts can be used to control the redefinition of services. In Eiffel, the rules ensure that redefinition is safe in the presence of polymorphism and dynamic binding. This paper shows that Eiffel`s support for contracts can be extended, both to cover the polymorphic case more fully, and to cover other uses of inheritance, including its use for selectively reusing code from a parent class. The paper proposes that software designers should state what properties they claim for any uses of inheritance, in order that extra checks on consistency can be applied, and shows that some extra debugging power could be obtained easily, by changing only the run-time system for Eiffel, rather than the language itself.

  16. Mechanics of Vorticella Contraction

    PubMed Central

    Misra, Gaurav; Dickinson, Richard B.; Ladd, Anthony J.C.

    2010-01-01

    Abstract Vorticella convallaria is one of a class of fast-moving organisms that can traverse its body size in less than a millisecond by rapidly coiling a slender stalk anchoring it to a nearby surface. The stalk houses a fiber called the spasmoneme, which winds helically within the stalk and rapidly contracts in response to calcium signaling. We have developed a coupled mechanical-chemical model of the coiling process, accounting for the coiling of the elastic stalk and the binding of calcium to the protein spasmin. Simulations of the model describe the contraction and recovery processes quantitatively. The stalk-spasmoneme system is shown to satisfy geometric constraints, which explains why the cell body sometimes rotates during contraction. The shape of the collapsing and recovering stalk bounds its effective bending stiffness. Simulations suggest that recovery from the contracted state is driven by the stalk at a rate controlled by dissociation of calcium from spasmin. PMID:20550905

  17. 3 CFR - Government Contracting

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... contract oversight could reduce such sums significantly. Government outsourcing for services also raises... governmental functions. Agencies and departments must operate under clear rules prescribing when outsourcing is... oversee acquisitions appropriately; and (4) clarify when governmental outsourcing for services is and...

  18. Affine Contractions on the Plane

    ERIC Educational Resources Information Center

    Celik, D.; Ozdemir, Y.; Ureyen, M.

    2007-01-01

    Contractions play a considerable role in the theory of fractals. However, it is not easy to find contractions which are not similitudes. In this study, it is shown by counter examples that an affine transformation of the plane carrying a given triangle onto another triangle may not be a contraction even if it contracts edges, heights or medians.…

  19. Educational Performance Contracting. PREP-28.

    ERIC Educational Resources Information Center

    National Center for Educational Communication (DHEW/OE), Washington, DC. Div. of Practice Improvement.

    This document explicates what is involved in educational performance contracting. Four basic types of contracts can be used to procure goods and services: fixed and performance contracts for resources and fixed and performance contracts for results. The basic considerations in choice of type are risk, relative technologies, management skills…

  20. Service contract management and negotiation.

    PubMed

    Wickesser, T A

    1994-04-01

    Service contract management can have a profound impact on the life cycle cost and general performance of serviced equipment. Negotiating service contracts from the client's perspective can help to ensure that the facility is receiving the best possible service and terms during the contract period. This document shows examples of contract considerations.

  1. Nested and Dynamic Contract Boundaries

    NASA Astrophysics Data System (ADS)

    Strickland, T. Stephen; Felleisen, Matthias

    Previous work on software contracts assumes fixed and statically known boundaries between the parties to a contract. Implementations of contract monitoring systems rely on this assumption to explain the nature of contract violations and to assign blame to violators. In this paper, we explain how to implement arbitrary, nested, and dynamic contract boundaries with two examples. First, we add nestable contract regions to a static, first-order module system. Second, we show that even a dynamic, higher-order, and hierarchical module system can be equipped with software contracts that support precise blame assignment.

  2. Synthesis and characterization of nano-HA/PA66 composites.

    PubMed

    Huang, Mei; Feng, Jianqing; Wang, Jianxin; Zhang, Xingdong; Li, Yubao; Yan, Yonggang

    2003-07-01

    Based on the bioactivity and biocompatibility of hydroxyapatite (HA) and the excellent mechanical performance of polyamide 66 (PA66), a composite of nanograde HA with PA66 was designed and fabricated to mimic the structure of biological bone which exhibits a composite of nanograde apatite crystals and natural polymer. The HA/PA66 composite combines the bioactivity of HA and the mechanical property of PA66. This study focused on the preparation method of HA/PA66 composite and the influence of HA crystals on the characterization of the composite. HA slurry was used directly to prepare HA/PA66 composite by a solution method, in which HA is able to form hydrogen bond, i.e. chemical bonding with PA66. The nano-HA needle-like crystals treated by hydrothermal method are better in the particle size distribution and the particle dispersion. The morphology, crystal structure and crystallinity as well as crystal size of these needle-like crystals are similar to bone apatite. The nano-HA needle-like crystals dispersed uniformly in PA66 matrix with reinforcement effect and can prevent the micro-crackle spreading into cleft and fracture during the deformation process. The mechanical testing shows that the nano-HA/PA66 composite has a good mechanical property, and may be a promising bone replacement material.

  3. Consensus, contracts, and committees.

    PubMed

    Moreno, J D

    1991-08-01

    Following a brief account of the puzzle that ethics committees present for the Western Philosophical tradition, I will examine the possibility that social contract theory can contribute to a philosophical account of these committees. Passing through classical as well as contemporary theories, particularly Rawls' recent constructivist approach, I will argue that social contract theory places severe constraints on the authority that may legitimately be granted to ethics committees. This, I conclude, speaks more about the suitability of the theory to this level of analysis than about the ethics committee phenomenon itself.

  4. 48 CFR 417.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting activity is authorized to approve contracts which exceed the 5 year limitation in FAR 17.204(e)....

  5. Impact of Telephone Reinforcement and Negotiated Contracts on Behavioral Predictors of Exercise Maintenance in Older Adults with Osteoarthritis

    PubMed Central

    Desai, Pankaja M.; Hughes, Susan L.; Peters, Karen E.; Mermelstein, Robin J.

    2014-01-01

    Objectives To examine the impact of telephone reinforcement (TR) on predictors of physical activity (PA) maintenance in older adults with osteoarthritis. Methods Mixed effects modeling was conducted of data from a randomized PA trial that used negotiated maintenance contracts, supplemented by TR, to test impact of TR on barriers, decisional balance, and stage of change at multiple points in time. Results Participants who were referred to a PA program and received TR improved the most in barriers and decisional balance. Participants who negotiated a tailored maintenance contract but did not receive TR improved the most in stage. Conclusions TR appears to positively affect perceptions around engagement, whereas negotiation positively impacts PA behavior. Further research should examine the effectiveness of specific PA maintenance strategies. PMID:25181766

  6. Mechanical Anisotropy of Rat Aortic Smooth Muscle Cells Decreases with Their Contraction

    NASA Astrophysics Data System (ADS)

    Nagayama, Kazuaki; Matsumoto, Takeo

    Tensile properties of smooth muscle cells freshly isolated from rat thoracic aortas (FSMCs) in their major and minor axes were measured using a laboratory-made micro tensile tester. The relationship between the tension applied to a cell and its elongation was obtained in untreated cells and those treated with 10-5M serotonin to induce contraction. An initial stiffness of untreated FSMCs, normalized by their initial cross-sectional area perpendicular to the stretch direction, was significantly higher in the major axis (14.8±4.3kPa, mean±SEM, n=5) than the minor axis (2.8±1.0kPa, n=5). The stiffness increased significantly in response to the contraction, but the increase was much higher in the minor axis (59.0±9.4kPa, n=4) than in the major (88.1±13.3kPa, n=4). The difference between the two directions was insignificant in the contracted state. Observations of the morphology of actin filaments with a confocal laser scanning microscope in untreated FSMCs revealed that they were long fibers running almost parallel to the major axis, while those in contracted cells showed an aggregated structure without a preferential direction. These results may indicate that anisotropy in untreated FSMCs is caused by the anisotropic alignment of their actin filaments, and that such anisotropy disappears in response to actin filament reorganization caused by the contraction.

  7. Acting Out Muscle Contraction.

    ERIC Educational Resources Information Center

    Hudson, Margaret

    2003-01-01

    Describes a science activity that can be implemented into anatomy and physiology courses that demonstrates the interactions between action and myosin, the roles of sodium and calcium ions in the regulation of contraction, and the functions of the plasma membrane and the sarcoplasmic reticulum. (YDS)

  8. Contracting for Audit Services.

    ERIC Educational Resources Information Center

    Heifetz, Harry S.

    1987-01-01

    The Single Audit Act of 1984 requires most school districts receiving over $25,000 in federal funds to undergo financial audits. This article highlights requirements for selecting certified public accountants to perform the audit and suggests factors to be considered before drafting a contract or letter of engagement. A sample letter is included.…

  9. Paradental Training Contract.

    ERIC Educational Resources Information Center

    Lane Community Coll., Eugene, OR.

    This report describes institutional, faculty, and student activities and problems resulting from Lane Community College's acceptance of a federal contract to develop a paradental training program designed specifically to provide training/retraining required to quality military-trained dental corpsmen for examination by the Oregon State Board of…

  10. Copyright or Contract?

    ERIC Educational Resources Information Center

    Okerson, Ann

    1997-01-01

    Most authors and publishers of electronic information believe that current copyright law does not address technical capabilities or reader uses and have turned to contracts or licenses to define the rights of owners and users. Discusses copyrights, fair use, and licenses and highlights licensing's unresolved issues: use and users; archiving;…

  11. Contracting for Learning.

    ERIC Educational Resources Information Center

    Donald, Janet G.

    1976-01-01

    A learning contract is a document, drawn up by a student and his instructor or advisor that specifies what the student will learn, how this will be accomplished, within what period of time, and what the criteria of evaluation will be. The student and instructor agree upon specific objectives, resources to be used, and feedback sessions.…

  12. Contracting for Classroom Services.

    ERIC Educational Resources Information Center

    McLaughlin, John; Brown, Senn

    2000-01-01

    Like county governments, hospitals, and municipalities, superintendents must develop policies and protocols for requesting proposals, administering contracts, and ensuring desired results of private-sector services. Administrators should consider performance criteria, legal issues, cost and efficiency analysis, contractor evaluation criteria, and…

  13. AhV_aPA-induced vasoconstriction involves the IP₃Rs-mediated Ca²⁺ releasing.

    PubMed

    Zeng, Fuxing; Zou, Zhisong; Niu, Liwen; Li, Xu; Teng, Maikun

    2013-08-01

    AhV_aPA, the acidic PLA₂ purified from Agkistrodon halys pallas venom, was previously reported to possess a strong enzymatic activity and can remarkably induce a further contractile response on the 60 mM K⁺-induced contraction with an EC₅₀ in 369 nM on mouse thoracic aorta rings. In the present study, we found that the p-bromo-phenacyl-bromide (pBPB), which can completely inhibit the enzymatic activity of AhV_aPA, did not significantly reduce the contractile response on vessel rings induced by AhV_aPA, indicating that the vasoconstrictor effects of AhV_aPA are independent of the enzymatic activity. The inhibitor experiments showed that the contractile response induced by AhV_aPA is mainly attributed to the Ca²⁺ releasing from Ca²⁺ store, especially sarcoplasmic reticulum (SR). Detailed studies showed that the Ca²⁺ release from SR is related to the activation of inositol trisphosphate receptors (IP₃Rs) rather than ryanodine receptors (RyRs). Furthermore, the vasoconstrictor effect could be strongly reduced by pre-incubation with heparin, indicating that the basic amino acid residues on the surface of AhV_aPA may be involved in the interaction between AhV_aPA and the molecular receptors. These findings offer new insights into the functions of snake PLA₂ and provide a novel pathogenesis of A. halys pallas venom. PMID:23648424

  14. 8. Photocopy to photograph (from Curtis Hottenstein, Bernville, Pa.) ca. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photocopy to photograph (from Curtis Hottenstein, Bernville, Pa.) ca. 1953, Photographer unknown AERIAL VIEW OF FARM - Dundore Farm, State Route 183 & Church Road vicinity, Penn Township (moved to Brownsville vicinity, Lower Heidelberg Township, Berks County), Mount Pleasant, Berks County, PA

  15. Genome Sequence of Pseudomonas chlororaphis Strain PA23

    PubMed Central

    Loewen, Peter C.; Villenueva, Jacylyn; Fernando, W. G. Dilantha

    2014-01-01

    Pseudomonas chlororaphis strain PA23 is a plant-beneficial bacterium that is able to suppress disease caused by the fungal pathogen Sclerotinia sclerotiorum through a process known as biological control. Here we present a 7.1-Mb assembly of the PA23 genome. PMID:25035328

  16. 33 CFR 110.67 - Delaware River, Essington, Pa.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North...

  17. 78 FR 27025 - Modification of Class B Airspace; Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... rulemaking (NPRM) to modify the Philadelphia, PA, Class B airspace area (77 FR 45290, July 31, 2012...: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389...; Philadelphia, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This...

  18. 77 FR 63727 - Drawbridge Operation Regulation; Schuylkill River, Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... Operation Regulation; Schuylkill River, Philadelphia, PA in the FR (77 FR 47792). We received no comments on... FR Federal Register NPRM Notice of Proposed Rulemaking Sec. Section Symbol U.S.C. United States Code..., Philadelphia, PA AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard is changing...

  19. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  20. Atomic structure of anthrax PA pore elucidates toxin translocation

    PubMed Central

    Jiang, Jiansen; Pentelute, Bradley L.; Collier, R. John; Zhou, Z. Hong

    2015-01-01

    Summary Anthrax toxin, comprising protective antigen (PA), lethal factor (LF) and edema factor (EF), is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in human and animals. PA forms oligomeric prepores that undergo conversion to membrane-spanning pores by endosomal acidification, and these pores translocate the enzymes LF and EF into the cytosol of target cells1. PA is not only a vaccine component and therapeutic target for anthrax infections but also an excellent model system for understanding the mechanism of protein translocation. Based on biochemical and electrophysiological results, researchers have proposed that a Φ-clamp composed of Phe427 residues of PA catalyzes protein translocation via a charge-state dependent Brownian ratchet2–9. Although atomic structures of PA prepores are available10–14, how PA senses low pH, converts to active pore and translocates LF and EF are not well defined without an atomic model of the PA pore. Here, by cryo electron microscopy (cryoEM) with direct electron counting, we have determined the PA pore structure at 2.9-Å resolution. The structure reveals the long-sought-after catalytic Φ-clamp and the membrane-spanning translocation channel, and supports the Brownian ratchet model for protein translocation. Comparisons of four structures reveal conformational changes in prepore to pore conversion that support a multi-step mechanism by which low-pH is sensed and the membrane-spanning channel is formed. PMID:25778700

  1. 78 FR 5137 - Safety Zone; Monongahela River, Charleroi, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    .... This rule will remain in effect through 5:00 p.m. on March 1, 2013. ADDRESSES: Documents mentioned in... conducted on a guard wall upstream of Lock and Dam in Charleroi, PA. B. Basis and Purpose The Joseph B. Fay... of guard wall upstream of Lock and Dam 4 in Charleroi, PA. This event poses hazardous conditions...

  2. Employee contract issues for dermatologists.

    PubMed

    Brown, Christopher E; Indest, George F

    2013-12-01

    Employees and employers routinely face negotiating and preparing physician employment contracts. It is important for both sides to know and understand the basic information on what a comprehensive employment contract for a dermatologist should contain. There are various employment contract provisions from both the employee's perspective and the employer's perspective that must be considered when preparing physician employment contracts. This article provides basic advice and recommendations on requirements that should be included in such contracts. It suggests legal pitfalls that can be avoided through various contract clauses.

  3. Employee contract issues for dermatologists.

    PubMed

    Brown, Christopher E; Indest, George F

    2013-12-01

    Employees and employers routinely face negotiating and preparing physician employment contracts. It is important for both sides to know and understand the basic information on what a comprehensive employment contract for a dermatologist should contain. There are various employment contract provisions from both the employee's perspective and the employer's perspective that must be considered when preparing physician employment contracts. This article provides basic advice and recommendations on requirements that should be included in such contracts. It suggests legal pitfalls that can be avoided through various contract clauses. PMID:24800433

  4. Observations of 231Pa/ 235U disequilibrium in volcanic rocks

    NASA Astrophysics Data System (ADS)

    Pickett, David A.; Murrell, Michael T.

    1997-04-01

    We present here the first survey of ( 231Pa/ 235U) ratios in volcanic rocks; such measurements are made possible by new mass spectrometric techniques. The data place new constraints on the timing and extent of magma source and evolutionary processes, particularly due to the sensitivity of the 231Pa- 235U pair and its intermediate time scale ( 231Pat 1/2 = 33 ky). ( 231Pa/ 235U) is found to vary widely, from 0.2 in carbonatites to 1.1-2.9 in basalts and 0.9-2.2 in arcs. Substantial Pa enrichment is nearly ubiquitous, suggestive of the relative incompatibility of Pa, qualitatively consistent with available partitioning data. The level of 231Pa- 235U disequilibrium typically far exceeds that of 230Th- 238U and is comparable to 226Ra- 230Th. The high ( 231Pa/ 235U) ratios in MORB and other basalts reflect a large degree of discrimination between two incompatible elements, posing challenges for modelling of melt generation and migration. Fundamental differences in ( 231Pa/ 235U) among different basaltic environments are likely related to contrasts in melting zone conditions (e.g., melting rate). Strong ( 231Pa/ 235U) disequilibria in continental basalts, for which ( 230Th/ 238U) disequilibria are small or absent, demonstrate that Pa-U fractionation is possible in both garnet and spinel mantle stability fields. In arcs, correlation of ( 231Pa/ 235U) and ( 230Th/ 238U) is consistent with U enrichment via slab-derived fluids, a process which is additional to the still dominant Pa enrichment. An important new constraint is provided by the observation that the near-equilibrium ( 230Th/ 238U) common to arcs and continental basalts is not typically accompanied by near-equilibrium ( 231Pa/ 235U), arguing against the influence of long magma history, crustal material, or equilibrium mantle sources in affecting decay-series ratios. Small sample sets from two silicic centers illustrate: (1) recent, rapid U enrichment in the magma chamber (El Chichón); and (2) the failure of

  5. Elucidating Protactinium Hydrolysis: The Relative Stabilities of PaO2(H2O)(+) and PaO(OH)2(+).

    PubMed

    Dau, Phuong D; Wilson, Richard E; Gibson, John K

    2015-08-01

    It is demonstrated that the gas-phase oxo-exchange of PaO2(+) with water is substantially faster than that of UO2(+), indicating that the Pa-O bonds are more susceptible to activation and formation of the bis-hydroxide intermediate, PaO(OH)2(+). To elucidate the nature of the water adduct of PaO2(+), hydration of PaO2(+) and UO2(+), as well as collision induced dissociation (CID) and ligand-exchange of the water adducts of PaO2(+) and UO2(+), was studied. The results indicate that, in contrast to UO2(H2O)(+), the protactinium oxo bis-hydroxide isomer, PaO(OH)2(+), is produced as a gas-phase species close in energy to the hydrate isomer, PaO2(H2O)(+). CID behavior similar to that of Th(OH)3(+) supports the assignment as PaO(OH)2(+). The gas-phase results are consistent with the spontaneous hydrolysis of PaO2(+) in aqueous solution, this in contrast to later AnO2(+) (An = U, Np, Pu), which forms stable hydrates in both solution and gas phase. In view of the known propensity for Th(IV) to hydrolyze, and previous gas-phase studies of other AnO2(+), it is concluded that the stabilities of oxo-hydroxides relative to oxide hydrates decreases in the order: Th(IV) > Pa(V) > U(V) > Np(V) > Pu(V). This trend suggests increasing covalency and decreasing ionicity of An-O bonds upon proceeding across the actinide series.

  6. Elucidating Protactinium Hydrolysis: The Relative Stabilities of PaO2(H2O)(+) and PaO(OH)2(+).

    PubMed

    Dau, Phuong D; Wilson, Richard E; Gibson, John K

    2015-08-01

    It is demonstrated that the gas-phase oxo-exchange of PaO2(+) with water is substantially faster than that of UO2(+), indicating that the Pa-O bonds are more susceptible to activation and formation of the bis-hydroxide intermediate, PaO(OH)2(+). To elucidate the nature of the water adduct of PaO2(+), hydration of PaO2(+) and UO2(+), as well as collision induced dissociation (CID) and ligand-exchange of the water adducts of PaO2(+) and UO2(+), was studied. The results indicate that, in contrast to UO2(H2O)(+), the protactinium oxo bis-hydroxide isomer, PaO(OH)2(+), is produced as a gas-phase species close in energy to the hydrate isomer, PaO2(H2O)(+). CID behavior similar to that of Th(OH)3(+) supports the assignment as PaO(OH)2(+). The gas-phase results are consistent with the spontaneous hydrolysis of PaO2(+) in aqueous solution, this in contrast to later AnO2(+) (An = U, Np, Pu), which forms stable hydrates in both solution and gas phase. In view of the known propensity for Th(IV) to hydrolyze, and previous gas-phase studies of other AnO2(+), it is concluded that the stabilities of oxo-hydroxides relative to oxide hydrates decreases in the order: Th(IV) > Pa(V) > U(V) > Np(V) > Pu(V). This trend suggests increasing covalency and decreasing ionicity of An-O bonds upon proceeding across the actinide series. PMID:26203499

  7. Determination of organic nitro compounds using HPLC-UV-PAED

    NASA Astrophysics Data System (ADS)

    Marple, Ronita L.; LaCourse, William R.

    2004-12-01

    High-performance liquid chromatography with ultra violet and photo-assisted electrochemical detection (HPLC-UV-PAED) has been applied to the sensitive and selective determination of organic nitro compounds. The system was first developed for the determination of nitro explosives, and PAED has shown superior sensitivity over UV detection for these compounds (i.e., <1 part-per-trillion for HMX). The system also shows enhanced selectivity over the traditional UV method in that two detectors can be used for improved analyte identification. Also, having two detectors permits chemometric resolution of overlapping peaks, and this is not addressed in the UV method. Because this method is applicable to a wide range of nitro explosives, it was predicted that PAED would show the same sensitivity and selectivity toward other types of nitro compounds. Since its development, the system's use has been expanded to include the determination of nitro-containing pharmaceuticals and glycosylated nitro compounds in biological matrices. Model compounds were chosen, specifically nitroglycerin and related compounds and nitrophenyl-glucoside, to represent these classes. PAED showed superior detection limits over low wavelength UV detection for nitroglycerin (PAED = 0.3ppb, UV at 220nm = 48ppb), demonstrating PAED"s applicability to determining nitro-pharmaceuticals. Conversely, UV detection at 220nm proved to be more sensitive than PAED for nitrophenyl-glucoside (UV at 220 = 0.6ppb, PAED = 3.6ppb). However, when nitrophenyl-glucoside was spiked into urine, PAED determination resulted in 99+0.3% recovery, while UV at 220nm resulted in 116+0.2% recovery, suggesting that UV determination may suffer from matrix interference.

  8. 48 CFR 1335.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.006 Contracting methods and... research involving human subjects to be carried out in performance of the award is exempt from 15 CFR part... Subjects, that the research involving human subjects is not exempt from the requirements of 15 CFR part...

  9. 48 CFR 17.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... that are not available in the fiscal year in which the contract would otherwise be completed. (e... CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify limits... contract, including any extension. (b) The contract shall state the period within which the option may...

  10. 48 CFR 16.302 - Cost contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Cost contracts. 16.302... AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.302 Cost contracts. (a) Description. A cost contract is a cost-reimbursement contract in which the contractor receives no fee....

  11. 48 CFR 16.302 - Cost contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost contracts. 16.302... AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.302 Cost contracts. (a) Description. A cost contract is a cost-reimbursement contract in which the contractor receives no fee....

  12. 48 CFR 217.7406 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Undefinitized Contract Actions 217.7406 Contract clauses. (a) Use the clause at FAR 52.216-24, Limitation of Government Liability...) Indefinite-delivery contracts; (5) Any other type of contract providing for the use of UCAs; and (6)...

  13. 48 CFR 217.7406 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Undefinitized Contract Actions 217.7406 Contract clauses. (a) Use the clause at FAR 52.216-24, Limitation of Government Liability...) Indefinite-delivery contracts; (5) Any other type of contract providing for the use of UCAs; and (6)...

  14. 48 CFR 217.7406 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Undefinitized Contract Actions 217.7406 Contract clauses. (a) Use the clause at FAR 52.216-24, Limitation of Government Liability...) Indefinite-delivery contracts; (5) Any other type of contract providing for the use of UCAs; and (6)...

  15. 48 CFR 217.7406 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Undefinitized Contract Actions 217.7406 Contract clauses. (a) Use the clause at FAR 52.216-24, Limitation of Government Liability...) Indefinite-delivery contracts; (5) Any other type of contract providing for the use of UCAs; and (6)...

  16. 48 CFR 217.7406 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Undefinitized Contract Actions 217.7406 Contract clauses. (a) Use the clause at FAR 52.216-24, Limitation of Government Liability...) Indefinite-delivery contracts; (5) Any other type of contract providing for the use of UCAs; and (6)...

  17. Utility Energy Services Contracts Guide

    SciTech Connect

    2013-09-01

    The UESC Guide is a compilation of samples and templates developed as a resource to help contracting officers implement task orders for UESCs under existing U.S. General Services Administration areawide contracts.

  18. Performance Contracting: Making It Legal

    ERIC Educational Resources Information Center

    Martin, Reed

    1971-01-01

    Discusses the possible limits on the legal authority of a school to contract with private enterprise for instructional services. The proper procedure for entering into such a contract is discussed. (JF)

  19. Contracts for dispatchable power

    SciTech Connect

    Kahn, E.P.; Stoft, S.; Marnay, C.; Berman, D.

    1990-10-01

    Competitive bidding for electric power is maturing. Increasing numbers of utilities are soliciting proposals from private suppliers. The amount of capacity being sought is increasing, and potential suppliers appear to be abundant. Analysis of these developments still remains limited. Evidence on the behavior of this market is scarce and sketchy. The underlying economic principles that are shaping the market have not clearly been articulated. In this report we examine the economics of competitive bidding both empirically and analytically. Previous study of this market has focused on the evaluation criteria specified in Requests for Proposals (RFPs), and highly aggregated summary statistics on participation and results. We continue the examination of RFPs, but also survey the details of long term contracts that have emerged from competitive bidding. Contracts provide a new level of specific detail that has not been previously available. 68 refs., 13 figs., 25 tabs.

  20. Russian Contract Procurement Document

    SciTech Connect

    Tobin, J G

    2010-03-29

    This contract supports the enhancement of physical protection or nuclear material control and accounting systems at institutes or enterprises of the newly independent states under the material protection control and accounting (MPC&A) program. The contract is entered into pursuant to the MPC&A Program, a gratuitous technical assistance program, in accordance with the bilateral Agreements between the Russian Federation and the United States of America concerning the Safe and Secure Transportation, Storage and Destruction of Weapons and the Prevention of Weapons Proliferation of June 1992, as extended and amended by Protocol signed of June 1999, Agreement between the Government of the Russian Federation regarding Cooperation in the Area of Nuclear Materials Physical Protection, Control and Accounting of October 1999 and the Russian Federation law of May 1999 on the taxation exemption of gratuitous technical assistance with Russian Federation under registration No.DOE001000.

  1. Biogeography in 231Pa/230Th ratios and a balanced 231Pa budget for the Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Hayes, Christopher T.; Anderson, Robert F.; Fleisher, Martin Q.; Serno, Sascha; Winckler, Gisela; Gersonde, Rainer

    2014-04-01

    The ratio of unsupported protactinium-231 to thorium-230 in marine sediments, (Pa/Th)xs, is potentially sensitive to several processes of oceanographic and climatological interest: deep ocean circulation, marine biological productivity (as it relates to total particle flux) and particle composition (specifically, biogenic opal and authigenic Mn). In order to attribute variations in (Pa/Th)xs observed in sediment records to changes in specific processes through time, a better understanding of the chemical cycling of these elements in the modern ocean is necessary. To this end, a survey was undertaken of (Pa/Th)xs in surface sediments from the subarctic Pacific (SO202-INOPEX expedition) in combination with a Pacific-wide compilation of published data. Throughout the Pacific, (Pa/Th)xs is robustly correlated with the opal content of sediments. In the North and equatorial Pacific, simultaneous positive correlations with productivity indicators suggest that boundary scavenging and opal scavenging combine to enhance the removal of Pa in the eastern equatorial Pacific and subarctic Pacific. Deep ocean water mass ageing (>3.5 km) associated with the Pacific overturning appears to play a secondary role in determining the basin scale distribution of (Pa/Th)xs. A basin-wide extrapolation of Pa removal is performed which suggests that the Pacific Pa budget is nearly in balance. We hypothesize that through time (Pa/Th)xs distributions in the Pacific could define the evolving boundaries of contrasting biogeographic provinces in the North Pacific, while the influence of hydrothermal scavenging of Pa potentially confounds this approach in the South Pacific.

  2. Microfluidic manufacture of rt-PA -loaded echogenic liposomes.

    PubMed

    Kandadai, Madhuvanthi A; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J; Papautsky, Ian; Holland, Christy K

    2016-06-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (μtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the μtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The μtELIP had a mean diameter of 5 μm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5 % bovine serum albumin. Additionally, 35 % of μtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes. PMID:27206512

  3. Microfluidic manufacture of rt-PA -loaded echogenic liposomes.

    PubMed

    Kandadai, Madhuvanthi A; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J; Papautsky, Ian; Holland, Christy K

    2016-06-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (μtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the μtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The μtELIP had a mean diameter of 5 μm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5 % bovine serum albumin. Additionally, 35 % of μtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes.

  4. Microfluidic manufacture of rt-PA-loaded echogenic liposomes

    PubMed Central

    Kandadai, Madhuvanthi A.; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J.; Papautsky, Ian; Holland, Christy K.

    2016-01-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (µtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the µtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The µtELIP had a mean diameter of 5 µm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5%bovine serum albumin. Additionally, 35 % of µtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes. PMID:27206512

  5. Elements of gas contracts

    SciTech Connect

    O`Neal, J.

    1995-12-01

    The gas marketing scene has taken on a new look from the days of the {open_quotes}Long Term{close_quotes} or {open_quotes}Life of Lease{close_quotes} Contracts. In the past natural gas was of ten sold direct from the wellhead or a producer-owned facility to a pipeline company at a flat rate price and the only parties involved were producer or seller and buyer. Today, the parties involved in the marketing process might include a gathering entity to gather gas at a central point and provide gathering, compression and/or dehydration services; multiple pipeline companies for transportation; sales representatives or marketing brokers to negotiate a sale of the available gas on a monthly basis; and purchasers or end users. New terms have also been introduced in the process such as: {open_quotes}LDC{close_quotes} (local distribution company), {open_quotes}FERC Order 636{close_quotes}, {open_quotes}Price Delivered-to-Pipeline{close_quotes} and the various {open_quotes}levels of Service{close_quotes} under Gas Sales and Purchase Agreements. Four common levels of service are: {open_quotes}Firm{close_quotes}, {open_quotes}Baseload{close_quotes}, {open_quotes}Swing{close_quotes} and {open_quotes}Baseload/Operational{close_quotes}. It is evident that current marketing plans often require a separate contract for each service or commitment. Contract contents vary greatly, but most contain the following elements.

  6. Health Contract in the Classroom

    ERIC Educational Resources Information Center

    Haber, David

    2007-01-01

    A health contract is a technique used by health professionals to help clients achieve a health goal. This article describes a course, "Changing Health Behaviors," in which a health contract strategy is taught and practiced with older adults. The health contract can also be included as a smaller educational component within a gerontology course…

  7. 48 CFR 1842.7202 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES NASA Contractor Financial Management... Contractor Financial Management Reporting, in solicitations and contracts when any of the NASA Form...

  8. 48 CFR 1842.7202 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES NASA Contractor Financial Management... Contractor Financial Management Reporting, in solicitations and contracts when any of the NASA Form...

  9. Cardiovascular responses to sustained maximal isometric contractions of the finger flexors.

    PubMed

    Smith, D L; Misner, J E; Bloomfield, D K; Essandoh, L K

    1993-01-01

    This study investigated cardiovascular responses to 2 min sustained submaximal (20% MVC) and maximal (100% MVC) voluntary isometric contractions of the finger flexors in healthy young women. Cardiovascular variables investigated were: heart rate (fc), mean arterial pressure (Pa), and stroke volume (SV). Doppler echocardiography was used to estimate SV from measures of aortic diameter (AD) and time-velocity integrals. Preliminary studies indicated that AD did not change significantly after 2 min sustained 100% MVC. Therefore, pre-exercise AD values were used to calculate SV before, during and after exercise. During the 2-min 100% MVC period, fc and Pa increased significantly during the first 30 s of contraction. fc then remained constant during the remainder of the 2-min contraction period, while Pa continued to rise. SV did not change significantly during the 100% MVC task but increased significantly during recovery from sustained 100% MVC. The data suggest that the magnitude of cardiovascular responses to isometric exercise is dependent on the specific task performed, and that there is a different pattern of response for fc, Pa, and SV during 20% and 100% MVC tasks. Unlike fc and Pa, SV did not change significantly during isometric exercise, but increased significantly after sustained 100% MVC. PMID:8375365

  10. 78 FR 7848 - Pennsylvania Disaster Number PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00057 AGENCY: U.S. Small Business Administration. ACTION.... ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration, Processing...

  11. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SECNAVINST 5210.8D). These reports shall be made available to PA program officials and to CNO (DNS-36)/CMC... until the next self-assessment is completed. Make these reports available, upon request, to CNO...

  12. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SECNAVINST 5210.8D). These reports shall be made available to PA program officials and to CNO (DNS-36)/CMC... until the next self-assessment is completed. Make these reports available, upon request, to CNO...

  13. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SECNAVINST 5210.8D). These reports shall be made available to PA program officials and to CNO (DNS-36)/CMC... until the next self-assessment is completed. Make these reports available, upon request, to CNO...

  14. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SECNAVINST 5210.8D). These reports shall be made available to PA program officials and to CNO (DNS-36)/CMC... until the next self-assessment is completed. Make these reports available, upon request, to CNO...

  15. Orion PA-1 Flight Test Crew Module Back at Dryden

    NASA Video Gallery

    The boilerplate Orion crew module and separation ring that was flown in the Launch Abort system PA-1 flight test at White Sands Missile Range, N.M., May 6 were airlifted back to NASA Dryden at Edwa...

  16. Active Contraction of Microtubule Networks

    NASA Astrophysics Data System (ADS)

    Foster, Peter; Fürthauer, Sebastian; Shelley, Michael; Needleman, Daniel

    Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the large scale behaviors of these systems. Here we investigate the self-organization of stabilized microtubules in Xenopus oocyte extracts and find that they can form macroscopic networks that spontaneously contract. We propose that these contractions are driven by the clustering of microtubule minus ends by dynein. Based on this idea, we construct an active fluid theory of network contractions which predicts a dependence of the timescale of contraction on initial network geometry, a development of density inhomogeneities during contraction, a constant final network density, and a strong influence of dynein inhibition on the rate of contraction, all in quantitative agreement with experiments. These results demonstrate that the motor-driven clustering of filament ends is a generic mechanism leading to contraction.

  17. Removal of 230Th and 231Pa at ocean margins

    NASA Astrophysics Data System (ADS)

    Anderson, Robert F.; Bacon, Michael P.; Brewer, Peter G.

    1983-12-01

    Uranium, thorium and protactinium isotopes were measured in particulate matter collected by sediment traps deployed in the Panama Basin and by in-situ filtration of large volumes of seawater in the Panama and Guatemala Basins. Concentrations of dissolved Th and Pa isotopes were determined by extraction onto MnO 2 adsorbers placed in line behind the filters in the in-situ pumping systems. Concentrations of dissolved 230Th and 231Pa in the Panama and Guatemala Basins are lower than in the open ocean, whereas dissolved 230Th/ 231Pa ratios are equal to, or slightly greater than, ratios in the open ocean. Particulate 230Th/ 231Pa ratios in the sediment trap samples ranged from 4 to 8, in contrast to ratios of 30 or more at the open ocean sites previously studied. Particles collected by filtration in the Panama Basin and nearest to the continental margin in the Guatemala Basin contained 230Th/ 231Pa ratios similar to the ratios in the sediment trap samples. The ratios increased with distance away from the continent. Suspended particles near the margin show no preference for adsorption of Th or Pa and therefore must be chemically different from particles in the open ocean, which show a strong preference for adsorption of Th. Ocean margins, as typified by the Panama and Guatemala Basins, are preferential sinks for 231Pa relative to 230Th. Furthermore, the margins are sinks for 230Th and, to a greater extent, 231Pa transported by horizontal mixing from the open ocean.

  18. The Lanthanide Contraction Revisited

    SciTech Connect

    Seitz, Michael; Oliver, Allen G.; Raymond, Kenneth N.

    2007-04-19

    A complete, isostructural series of lanthanide complexes (except Pm) with the ligand TREN-1,2-HOIQO has been synthesized and structurally characterized by means of single-crystal X-ray analysis. All complexes are 1D-polymeric species in the solid state, with the lanthanide being in an eight-coordinate, distorted trigonal-dodecahedral environment with a donor set of eight unique oxygen atoms. This series constitutes the first complete set of isostructural lanthanide complexes with a ligand of denticity greater than two. The geometric arrangement of the chelating moieties slightly deviates across the lanthanide series, as analyzed by a shape parameter metric based on the comparison of the dihedral angles along all edges of the coordination polyhedron. The apparent lanthanide contraction in the individual Ln-O bond lengths deviates considerably from the expected quadratic decrease that was found previously in a number of complexes with ligands of low denticity. The sum of all bond lengths around the trivalent metal cation, however, is more regular, showing an almost ideal quadratic behavior across the entire series. The quadratic nature of the lanthanide contraction is derived theoretically from Slater's model for the calculation of ionic radii. In addition, the sum of all distances along the edges of the coordination polyhedron show exactly the same quadratic dependency as the Ln-X bond lengths. The universal validity of this coordination sphere contraction, concomitant with the quadratic decrease in Ln-X bond lengths, was confirmed by reexamination of four other, previously published, almost complete series of lanthanide complexes. Due to the importance of multidentate ligands for the chelation of rare-earth metals, this result provides a significant advance for the prediction and rationalization of the geometric features of the corresponding lanthanide complexes, with great potential impact for all aspects of lanthanide coordination.

  19. 48 CFR 3035.7000 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SECURITY ACQUISITION REGULATION (HSAR) SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Information Dissemination by Educational Institutions 3035.7000 Contract clause. The contracting officer may use the clause at (HSAR) 48 CFR 3052.235-70, Dissemination of...

  20. 48 CFR 2442.1107 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production Surveillance and Reporting 2442.1107 Contract clause... value of $500,000 or less. (d) The clause shall not be used in contracts for information...

  1. 48 CFR 39.107 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY General 39.107 Contract clause. The contracting officer..., in solicitations and contracts for information technology which require security of information... information technology services or support services....

  2. 48 CFR 2415.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING METHODS AND CONTRACTING TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 2415.204 Contract format. (e) The cognizant HCA shall be responsible for making...

  3. 48 CFR 517.109 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Multiyear Contracting 517.109 Contract clauses. Use of... by 40 U.S.C. 490(a)(14) for maintenance and repair of fixed equipment in federally-owned...

  4. 48 CFR 2417.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e) The Senior Procurement Executive shall approve any solicitation or contract which exceeds the five (5) year maximum...

  5. 48 CFR 2132.617 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Debts 2132.617 Contract clause. The clause at FAR 52.232-17 is modified in FEGLI Program...

  6. 48 CFR 1632.617 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HEALTH BENEFITS ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Debts 1632.617 Contract clause. The clause at (FAR) 48 CFR 52.232-17 will be modified in all FEHBP...

  7. 48 CFR 315.209 - Solicitation provisions and contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICES CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 315.209 Solicitation provisions and contract clauses. (a) The Contracting...

  8. 48 CFR 15.204-1 - Uniform contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 15.204-1 Uniform contract format. (a) Contracting officers shall prepare solicitations...

  9. The Pediocin PA-1 Accessory Protein Ensures Correct Disulfide Bond Formation in the Antimicrobial Peptide Pediocin PA-1.

    PubMed

    Oppegård, Camilla; Fimland, Gunnar; Anonsen, Jan Haug; Nissen-Meyer, Jon

    2015-05-19

    Peptides, in contrast to proteins, are generally not large enough to form stable and well-defined three-dimensional structures. However, peptides are still able to form correct disulfide bonds. Using pediocin-like bacteriocins, we have examined how this may be achieved. Some pediocin-like bacteriocins, such as pediocin PA-1 and sakacin P[N24C+44C], have four cysteines. There are three possible ways by which the four cysteines may combine to form two disulfide bonds, and the three variants are expected to be produced in approximately equal amounts if their formation is random. Pediocin PA-1 and sakacin P[N24C+44C] with correct disulfide bonds were the main products when they were secreted by the pediocin PA-1 ABC transporter and accessory protein, but when they were secreted by the corresponding secretion machinery for sakacin A, a pediocin-like bacteriocin with one disulfide bond (two cysteines), peptides with all three possible disulfide bonds were produced in approximately equal amounts. All five cysteines in the pediocin PA-1 ABC transporter and the two cysteines (that form a CxxC motif) in the accessory protein were individually replaced with serines to examine their involvement in disulfide bond formation in pediocin PA-1. The Cys86Ser mutation in the accessory protein caused a 2-fold decrease in the amount of pediocin PA-1 with correct disulfide bonds, while the Cys83Ser mutation nearly abolished the production of pediocin PA-1 and resulted in the production of all three disufide bond variants in equal amounts. The Cys19Ser mutation in the ABC transporter completely abolished secretion of pediocin PA-1, suggesting that Cys19 is in the proteolytic active site and involved in cleaving the prebacteriocin. Replacing the other four cysteines in the ABC transporter with serines caused a slight reduction in the overall amount of secreted pediocin PA-1, but the relative amount with the correct disulfide bonds remained large. These results indicate that the pediocin

  10. Insights Into the PA Neutral Atom: from AN Evaluation of PA2+ Outer-Core Correlation Energy Calculations

    NASA Astrophysics Data System (ADS)

    Mrozik, Michael K.; Pitzer, Russell M.; Bursten, Bruce E.

    2010-06-01

    Since the identification of f-orbital contribution to the bonding in PaO+, investigations into Pa cations have hoped to characterize as many of the electronic states possible.1 Electronic states of the Pan+ (n=0-4) ions have been investigated using multi-reference spin-orbit configuration interaction (MR-SOCI). Initial investigations using Dunning style correlation consistent double-{ζ} basis sets are re-examined with a larger triple-{ζ} basis, with the hope of supporting the order of electronic states. Calculations using Hartree-Fock and CI calculations on the neutral atom did not produce the known order of states. A case study was deemed necessary on similar electron configurations present in the low energy states of Pa2+ more specifically those generated from the 5f26d1 and 5f16d2 configurations. Comparison in the Pa2+ ion is complicated by the lack of experimental results, but the states are presumed to be similar sequence as those in the neutral atom, with the addition of two electrons in the 7s shell. In evaluating the impact of inclusion of the outer core, calculations including valence-outer core correlation were completed for the 5d, 6s, and 6p shells of the Pa2+ ion. The magnitude of these individual shell correlation calculations will allow for identification of the energy level shifts associated with even and odd configurations, better describing the energy order in both the Pa2+ ion case study and for the neutral Pa atom. Upon completion of this aspect of the Pa neutral atom study, the knowledge of the energy levels in the Pan+ (n=0-4) family of ions will be greatly expanded, and may yield a model for future studies of atomic actinide systems. Gibson {et al.} Organometallics 2007, 26, 3947-3956.

  11. Detection of anthrax protective antigen (PA) using europium labeled anti-PA monoclonal antibody and time-resolved fluorescence.

    PubMed

    Stoddard, Robyn A; Quinn, Conrad P; Schiffer, Jarad M; Boyer, Anne E; Goldstein, Jason; Bagarozzi, Dennis A; Soroka, Stephen D; Dauphin, Leslie A; Hoffmaster, Alex R

    2014-06-01

    Inhalation anthrax is a rare but acute infectious disease following adsorption of Bacillus anthracis spores through the lungs. The disease has a high fatality rate if untreated, but early and correct diagnosis has a significant impact on case patient recovery. The early symptoms of inhalation anthrax are, however, non-specific and current anthrax diagnostics are primarily dependent upon culture and confirmatory real-time PCR. Consequently, there may be a significant delay in diagnosis and targeted treatment. Rapid, culture-independent diagnostic tests are therefore needed, particularly in the context of a large scale emergency response. The aim of this study was to evaluate the ability of monoclonal antibodies to detect anthrax toxin proteins that are secreted early in the course of B. anthracis infection using a time-resolved fluorescence (TRF) immunoassay. We selected monoclonal antibodies that could detect protective antigen (PA), as PA83 and also PA63 and LF in the lethal toxin complex. The assay reliable detection limit (RDL) was 6.63×10(-6)μM (0.551ng/ml) for PA83 and 2.51×10(-5)μM (1.58ng/ml) for PA63. Despite variable precision and accuracy of the assay, PA was detected in 9 out of 10 sera samples from anthrax confirmed case patients with cutaneous (n=7), inhalation (n=2), and gastrointestinal (n=1) disease. Anthrax Immune Globulin (AIG), which has been used in treatment of clinical anthrax, interfered with detection of PA. This study demonstrates a culture-independent method of diagnosing anthrax through the use of monoclonal antibodies to detect PA and LF in the lethal toxin complex.

  12. TraceContract

    NASA Technical Reports Server (NTRS)

    Kavelund, Klaus; Barringer, Howard

    2012-01-01

    TraceContract is an API (Application Programming Interface) for trace analysis. A trace is a sequence of events, and can, for example, be generated by a running program, instrumented appropriately to generate events. An event can be any data object. An example of a trace is a log file containing events that a programmer has found important to record during a program execution. Trace - Contract takes as input such a trace together with a specification formulated using the API and reports on any violations of the specification, potentially calling code (reactions) to be executed when violations are detected. The software is developed as an internal DSL (Domain Specific Language) in the Scala programming language. Scala is a relatively new programming language that is specifically convenient for defining such internal DSLs due to a number of language characteristics. This includes Scala s elegant combination of object-oriented and functional programming, a succinct notation, and an advanced type system. The DSL offers a combination of data-parameterized state machines and temporal logic, which is novel. As an extension of Scala, it is a very expressive and convenient log file analysis framework.

  13. 48 CFR 1517.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve a contract...

  14. 48 CFR 817.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer must obtain the approval of the DSPE before awarding a contract that includes options exceeding the 5-year limitation specified in FAR 17.204(e). This requirement does not apply to contracts to be awarded by or...

  15. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract files. 4.802... MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract file, that documents the basis for the acquisition and the...

  16. 48 CFR 1846.470 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 1846.470 Contract clause. The contracting officer may insert a clause substantially as stated at 1852.246-71, Government Contract Quality... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contract clause....

  17. 48 CFR 1846.470 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 1846.470 Contract clause. The contracting officer may insert a clause substantially as stated at 1852.246-71, Government Contract Quality... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract clause....

  18. 48 CFR 1846.470 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 1846.470 Contract clause. The contracting officer may insert a clause substantially as stated at 1852.246-71, Government Contract Quality... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract clause....

  19. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract file, that documents the basis for the acquisition and the award... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Contract files....

  20. 48 CFR 1846.470 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 1846.470 Contract clause. The contracting officer may insert a clause substantially as stated at 1852.246-71, Government Contract Quality... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause....

  1. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract file, that documents the basis for the acquisition and the award... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contract files....

  2. 48 CFR 32.611 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 32.611 Section 32.611 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Debts 32.611 Contract clause. (a) The contracting officer shall...

  3. 48 CFR 3416.307 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 3416.307 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 3416.307 Contract clauses. (a) If the clause in FAR 52.216-7, Allowable cost and Payment, is used in a contract with...

  4. 48 CFR 1316.406 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1316.406 Section 1316.406 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 1316.406 Contract clauses. Insert a...

  5. 48 CFR 716.406 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 716.406 Section 716.406 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost Reimbursement Contracts 716.406 Contract clauses....

  6. 231Pa systematics in postglacial volcanic rocks from Iceland

    NASA Astrophysics Data System (ADS)

    Turner, Simon; Kokfelt, Thomas; Hoernle, Kaj; Lundstrom, Craig; Hauff, Folkmar

    2016-07-01

    Several recent studies have highlighted the potential of combined 238U-230Th and 235U-231Pa systematics to constrain upwelling rates and the role of recycled mafic lithologies in mantle plume-derived basalts. Accordingly, we present measurements of the 231Pa concentrations from 26 mafic volcanic rocks from Iceland, including off-axis basalts from the Snaefellsnes Peninsula, to complement previously published 238U-230Th-226Ra data. 231Pa concentrations vary from 27 to 624 fg/g and (231Pa/235U) ratios from 1.12 to 2.11 with the exception of one anomalous sample from the Southeast Rift which has a 231Pa deficit with (231Pa/235U) = 0.86. An important new result is that basalts from the Southeast Rift and the Snaefellsnes Peninsula define a trend at relatively low (231Pa/235U) for a given (230Th/238U) ratio. Many of the remaining samples fall in or around the global field for ocean island basalts but those from the Mid-Iceland Belt and the Southwest Rift/Reykjanes Peninsula extend to higher (231Pa/235U) ratios at a given (230Th/238U), similar to mid-ocean ridge basalts. In principle, these lavas could result from melting of peridotite at lower pressures. However, there is no reason to suspect that the Mid-Iceland Belt and the Southwest Rift lavas reflect shallower melting than elsewhere in Iceland. In our preferred model, these lavas reflect melting of garnet peridotite whereas those from the Southeast Rift and the Snaefellsnes Peninsula contain a significant contribution (up to 20%) of melt from garnet pyroxenite. This is consistent with incompatible trace element and radiogenic isotope evidence for recycled oceanic crust in these lavas. There is increasing agreement that the displacement of ocean island basalts to lower (231Pa/235U) ratios at a given (230Th/238U), compared to mid-ocean ridge basalts, reflects the role of recycled mafic lithologies such as garnet pyroxenite as well as higher average pressures of melting. It now seems likely that this interpretation may

  7. Efficacy of histotripsy combined with rt-PA in vitro.

    PubMed

    Bader, Kenneth B; Haworth, Kevin J; Shekhar, Himanshu; Maxwell, Adam D; Peng, Tao; McPherson, David D; Holland, Christy K

    2016-07-21

    Histotripsy, a form of therapeutic ultrasound that uses the mechanical action of microbubble clouds for tissue ablation, is under development to treat chronic deep vein thrombosis (DVT). We hypothesize that combining thrombolytic agents with histotripsy will enhance clot lysis. Recombinant tissue plasminogen activator (rt-PA) and rt-PA-loaded echogenic liposomes that entrain octafluoropropane microbubbles (OFP t-ELIP) were used in combination with highly shocked histotripsy pulses. Fully retracted porcine venous clots, with similar features of DVT occlusions, were exposed either to histotripsy pulses alone (peak negative pressures of 7-20 MPa), histotripsy and OFP t-ELIP, or histotripsy and rt-PA. Microbubble cloud activity was monitored with passive cavitation imaging during histotripsy exposure. The power levels of cavitation emissions from within the clot were not statistically different between treatment types, likely due to the near instantaneous rupture and destruction of OFP t-ELIP. The thrombolytic efficacy was significantly improved in the presence of rt-PA. These results suggest the combination of histotripsy and rt-PA could serve as a potent therapeutic strategy for the treatment of DVT. PMID:27353199

  8. Efficacy of histotripsy combined with rt-PA in vitro

    NASA Astrophysics Data System (ADS)

    Bader, Kenneth B.; Haworth, Kevin J.; Shekhar, Himanshu; Maxwell, Adam D.; Peng, Tao; McPherson, David D.; Holland, Christy K.

    2016-07-01

    Histotripsy, a form of therapeutic ultrasound that uses the mechanical action of microbubble clouds for tissue ablation, is under development to treat chronic deep vein thrombosis (DVT). We hypothesize that combining thrombolytic agents with histotripsy will enhance clot lysis. Recombinant tissue plasminogen activator (rt-PA) and rt-PA-loaded echogenic liposomes that entrain octafluoropropane microbubbles (OFP t-ELIP) were used in combination with highly shocked histotripsy pulses. Fully retracted porcine venous clots, with similar features of DVT occlusions, were exposed either to histotripsy pulses alone (peak negative pressures of 7–20 MPa), histotripsy and OFP t-ELIP, or histotripsy and rt-PA. Microbubble cloud activity was monitored with passive cavitation imaging during histotripsy exposure. The power levels of cavitation emissions from within the clot were not statistically different between treatment types, likely due to the near instantaneous rupture and destruction of OFP t-ELIP. The thrombolytic efficacy was significantly improved in the presence of rt-PA. These results suggest the combination of histotripsy and rt-PA could serve as a potent therapeutic strategy for the treatment of DVT.

  9. Morphological studies on block copolymer modified PA 6 blends

    NASA Astrophysics Data System (ADS)

    Poindl, M.; Bonten, C.

    2014-05-01

    Recent studies show that compounding polyamide 6 (PA 6) with a PA 6 polyether block copolymers made by reaction injection molding (RIM) or continuous anionic polymerization in a reactive extrusion process (REX) result in blends with high impact strength and high stiffness compared to conventional rubber blends. In this paper, different high impact PA 6 blends were prepared using a twin screw extruder. The different impact modifiers were an ethylene propylene copolymer, a PA PA 6 polyether block copolymer made by reaction injection molding and one made by reactive extrusion. To ensure good particle matrix bonding, the ethylene propylene copolymer was grafted with maleic anhydride (EPR-g-MA). Due to the molecular structure of the two block copolymers, a coupling agent was not necessary. The block copolymers are semi-crystalline and partially cross-linked in contrast to commonly used amorphous rubbers which are usually uncured. The combination of different analysis methods like atomic force microscopy (AFM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) gave a detailed view in the structure of the blends. Due to the partial cross-linking, the particles of the block copolymers in the blends are not spherical like the ones of ethylene propylene copolymer. The differences in molecular structure, miscibility and grafting of the impact modifiers result in different mechanical properties and different blend morphologies.

  10. Morphological studies on block copolymer modified PA 6 blends

    SciTech Connect

    Poindl, M. E-mail: christian.bonten@ikt.uni-stuttgart.de; Bonten, C. E-mail: christian.bonten@ikt.uni-stuttgart.de

    2014-05-15

    Recent studies show that compounding polyamide 6 (PA 6) with a PA 6 polyether block copolymers made by reaction injection molding (RIM) or continuous anionic polymerization in a reactive extrusion process (REX) result in blends with high impact strength and high stiffness compared to conventional rubber blends. In this paper, different high impact PA 6 blends were prepared using a twin screw extruder. The different impact modifiers were an ethylene propylene copolymer, a PA PA 6 polyether block copolymer made by reaction injection molding and one made by reactive extrusion. To ensure good particle matrix bonding, the ethylene propylene copolymer was grafted with maleic anhydride (EPR-g-MA). Due to the molecular structure of the two block copolymers, a coupling agent was not necessary. The block copolymers are semi-crystalline and partially cross-linked in contrast to commonly used amorphous rubbers which are usually uncured. The combination of different analysis methods like atomic force microscopy (AFM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) gave a detailed view in the structure of the blends. Due to the partial cross-linking, the particles of the block copolymers in the blends are not spherical like the ones of ethylene propylene copolymer. The differences in molecular structure, miscibility and grafting of the impact modifiers result in different mechanical properties and different blend morphologies.

  11. Efficacy of histotripsy combined with rt-PA in vitro.

    PubMed

    Bader, Kenneth B; Haworth, Kevin J; Shekhar, Himanshu; Maxwell, Adam D; Peng, Tao; McPherson, David D; Holland, Christy K

    2016-07-21

    Histotripsy, a form of therapeutic ultrasound that uses the mechanical action of microbubble clouds for tissue ablation, is under development to treat chronic deep vein thrombosis (DVT). We hypothesize that combining thrombolytic agents with histotripsy will enhance clot lysis. Recombinant tissue plasminogen activator (rt-PA) and rt-PA-loaded echogenic liposomes that entrain octafluoropropane microbubbles (OFP t-ELIP) were used in combination with highly shocked histotripsy pulses. Fully retracted porcine venous clots, with similar features of DVT occlusions, were exposed either to histotripsy pulses alone (peak negative pressures of 7-20 MPa), histotripsy and OFP t-ELIP, or histotripsy and rt-PA. Microbubble cloud activity was monitored with passive cavitation imaging during histotripsy exposure. The power levels of cavitation emissions from within the clot were not statistically different between treatment types, likely due to the near instantaneous rupture and destruction of OFP t-ELIP. The thrombolytic efficacy was significantly improved in the presence of rt-PA. These results suggest the combination of histotripsy and rt-PA could serve as a potent therapeutic strategy for the treatment of DVT.

  12. Performance of CF/PA12 composite femoral stems.

    PubMed

    Campbell, Melissa; Bureau, Martin N; Yahia, L'Hocine

    2008-02-01

    This study presents the microstructural and mechanical behavior of the CF/PA12 composite material developed as well as its biomechanical performance when used for the fabrication of femoral stems. The static tests were performed to evaluate the compressive and flexural modulus as well as the ultimate compressive and bending strength. It was found that CF/PA12 composite had bone-matching properties in the same order of magnitude as cortical bone in the femur. Density and void content measurements were also done to assess the consolidation quality. Dynamic fatigue testing was conducted on both CF/PA12 cylinders and femoral stems to evaluate the long term durability and mechanical reliability of the composite. Compression-compression cyclic loading was used at a frequency of 6 Hz with loads varying between 17 kN and 22 kN for the composite cylinders while a frequency of 10 Hz and load of 2300 N was employed for the femoral stems. Results indicate that the fatigue performance of CF/PA12 composite surpasses by far the required fatigue performance for total hip prosthesis (THP) stems. The overall performance of the CF/PA12 femoral stems confirms that this composite is an excellent candidate material for orthopedic applications such as THP stems. PMID:17619978

  13. Efficacy of histotripsy combined with rt-PA in vitro

    NASA Astrophysics Data System (ADS)

    Bader, Kenneth B.; Haworth, Kevin J.; Shekhar, Himanshu; Maxwell, Adam D.; Peng, Tao; McPherson, David D.; Holland, Christy K.

    2016-07-01

    Histotripsy, a form of therapeutic ultrasound that uses the mechanical action of microbubble clouds for tissue ablation, is under development to treat chronic deep vein thrombosis (DVT). We hypothesize that combining thrombolytic agents with histotripsy will enhance clot lysis. Recombinant tissue plasminogen activator (rt-PA) and rt-PA-loaded echogenic liposomes that entrain octafluoropropane microbubbles (OFP t-ELIP) were used in combination with highly shocked histotripsy pulses. Fully retracted porcine venous clots, with similar features of DVT occlusions, were exposed either to histotripsy pulses alone (peak negative pressures of 7-20 MPa), histotripsy and OFP t-ELIP, or histotripsy and rt-PA. Microbubble cloud activity was monitored with passive cavitation imaging during histotripsy exposure. The power levels of cavitation emissions from within the clot were not statistically different between treatment types, likely due to the near instantaneous rupture and destruction of OFP t-ELIP. The thrombolytic efficacy was significantly improved in the presence of rt-PA. These results suggest the combination of histotripsy and rt-PA could serve as a potent therapeutic strategy for the treatment of DVT.

  14. Uterine Contraction Modeling and Simulation

    NASA Technical Reports Server (NTRS)

    Liu, Miao; Belfore, Lee A.; Shen, Yuzhong; Scerbo, Mark W.

    2010-01-01

    Building a training system for medical personnel to properly interpret fetal heart rate tracing requires developing accurate models that can relate various signal patterns to certain pathologies. In addition to modeling the fetal heart rate signal itself, the change of uterine pressure that bears strong relation to fetal heart rate and provides indications of maternal and fetal status should also be considered. In this work, we have developed a group of parametric models to simulate uterine contractions during labor and delivery. Through analysis of real patient records, we propose to model uterine contraction signals by three major components: regular contractions, impulsive noise caused by fetal movements, and low amplitude noise invoked by maternal breathing and measuring apparatus. The regular contractions are modeled by an asymmetric generalized Gaussian function and least squares estimation is used to compute the parameter values of the asymmetric generalized Gaussian function based on uterine contractions of real patients. Regular contractions are detected based on thresholding and derivative analysis of uterine contractions. Impulsive noise caused by fetal movements and low amplitude noise by maternal breathing and measuring apparatus are modeled by rational polynomial functions and Perlin noise, respectively. Experiment results show the synthesized uterine contractions can mimic the real uterine contractions realistically, demonstrating the effectiveness of the proposed algorithm.

  15. 48 CFR 235.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... production option on a development contract for a major weapon system reasonably in advance of the expiration of the option exercise period. (ii) For other than major defense acquisition programs— (A) Do not... permits realistic pricing; (2) The use of a fixed-price type contract permits an equitable and...

  16. 48 CFR 235.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... production option on a development contract for a major weapon system reasonably in advance of the expiration of the option exercise period. (ii) For other than major defense acquisition programs— (A) Do not... permits realistic pricing; (2) The use of a fixed-price type contract permits an equitable and...

  17. 48 CFR 235.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... production option on a development contract for a major weapon system reasonably in advance of the expiration of the option exercise period. (ii) For other than major defense acquisition programs— (A) Do not... permits realistic pricing; (2) The use of a fixed-price type contract permits an equitable and...

  18. PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

    PubMed Central

    Singh, Ramandeep; Manjunatha, Ujjini; Boshoff, Helena I. M.; Ha, Young Hwan; Niyomrattanakit, Pornwaratt; Ledwidge, Richard; Dowd, Cynthia S.; Lee, Ill Young; Kim, Pilho; Zhang, Liang; Kang, Sunhee; Keller, Thomas H.; Jiricek, Jan; Barry, Clifton E.

    2009-01-01

    Bicyclic nitroimidazoles, including PA-824, are exciting candidates for the treatment of tuberculosis. These prodrugs require intracellular activation for their biological function. We found that Rv3547 is a deazaflavin-dependent nitroreductase (Ddn) that converts PA-824 into three primary metabolites; the major one is the corresponding des-nitroimidazole (des-nitro). When derivatives of PA-824 were used, the amount of des-nitro metabolite formed was highly correlated with anaerobic killing of Mycobacterium tuberculosis (Mtb). Des-nitro metabolite formation generated reactive nitrogen species, including nitric oxide (NO), which are the major effectors of the anaerobic activity of these compounds. Furthermore, NO scavengers protected the bacilli from the lethal effects of the drug. Thus, these compounds may act as intracellular NO donors and could augment a killing mechanism intrinsic to the innate immune system. PMID:19039139

  19. Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA.

    PubMed

    Kleinschmidt-DeMasters, Bette K; Donson, Andrew M; Vogel, Hannes; Foreman, Nicholas K

    2015-07-01

    Pilomyxoid astrocytomas (PMAs) manifest a more aggressive clinical course than pilocytic astrocytomas (PAs). Development of effective therapies demands a better biological understanding of PMA. We first conducted gene expression microarray analysis of 9 PMA and 13 PA from infra- and supratentorial sites. Unsupervised hierarchical clustering analysis demonstrated that tumors are grouped according to anatomic site, not diagnosis. Gene expression profiles were then contrasted between eight PMAs and six PAs, all supratentorial/hypothalamic/chiasmal. Clinical outcome of PMAs varied, with four out of four patients with diencephalic syndrome succumbing to disease, one of whom showed bulky metastatic leptomeningeal spread at autopsy, with bimodal maturation to PA in some areas and de-differentiation to glioblastoma in others. A surviving child has undergone multiple surgical debulking, with progressive maturation to PA over time. Ontology-enrichment analysis identified overexpression in PMAs of extracellular matrix and mitosis-related genes. Genes overexpressed in PMA vs. PA, ranked according to fold-change, included developmental genes H19, DACT2, extracellular matrix collagens (COL2A1; COL1A1) and IGF2BP3 (IMP3), the latter previously identified as an adverse prognostic factor in PMA and PA.

  20. Pilomyxoid astrocytoma (PMA) shows significant differences in gene expression versus pilocytic astrocytoma (PA) and variable tendency toward maturation to PA

    PubMed Central

    Kleinschmidt-DeMasters, B.K.; Donson, Andrew M.; Vogel, Hannes; Foreman, Nicholas K.

    2015-01-01

    Pilomyxoid astrocytomas (PMAs) manifest a more aggressive clinical course than pilocytic astrocytomas (PAs). Development of effective therapies demands a better biological understanding of PMA. We first conducted gene expression microarray analysis of 9 PMA and 13 PA from infra- and supra-tentorial sites. Unsupervised hierarchical clustering analysis demonstrated that tumors grouped according to anatomic site, not diagnosis. Gene expression profiles were then contrasted between 8 PMAs and 6 PAs, all supratentorial/hypothalamic/chiasmal. Clinical outcome of PMAs varied, with 4/4 patients with diencephalic syndrome succumbing to disease, one of whom showed bulky metastatic leptomeningeal spread at autopsy, with bimodal maturation to PA in some areas and de-differentiation to glioblastoma in others. A surviving child has undergone multiple surgical debulkings, with progressive maturation to PA over time. Ontology-enrichment analysis identified overexpression in PMAs of extracellular matrix and mitosis-related genes. Genes overexpressed in PMA versus PA, ranked according to fold-change, included developmental genes H19, DACT2, extracellular matrix collagens (COL2A1;COL1A1) and IGF2BP3 (IMP3), the latter previously identified as an adverse prognostic factor in PMA and PA. PMID:25521223

  1. Shuttle GPS R/PA configuration and specification study

    NASA Technical Reports Server (NTRS)

    Booth, R. W. D.

    1979-01-01

    Changes in the technical specifications for a global positioning system (GPS) receiving system dedicated to space shuttle use are presented. Various hardware functions including acquisition, tracking, and measurement are emphasized. The anti-jam performance of the baseline GPS systems are evaluated. Other topics addressed include: the impact on R/PA design of the use of ground based transmitters; problems involved with the use of single channel tests sets; utility of various R/PA antenna interconnections topologies; the choice of the averaging interval for delta range measurements; and the use of interferometry techniques for the computation of orbiter attitude were undertaken.

  2. Oxidation of Gas-Phase Protactinium Ions, Pa+ and Pa2+: Formation and Properties of PaO22+(g), Protactinyl

    SciTech Connect

    Santos, M.; de Matos, A. Pires; Marcalo, J.; Gibson, John K; Haire, Richard {Dick} G; Tyagi, R.; Pitzer, R. M.

    2006-01-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N{sub 2}O to the relatively weak CH{sub 2}O - all oxidized Pa{sup +} to PaO{sup +} and PaO{sup +} to PaO{sub 2}{sup +}. On the basis of experimental observations, it was established that D[Pa{sup +}-O] and D[OPa{sup +}-O] {ge} 751 kJ mol{sup -1}. Estimates for D[Pa{sup +}-O], D[OPa{sup +}-O], IE[PaO], and IE[PaO{sub 2}] were also obtained. The seven oxidants reacted with Pa{sup 2+} to produce PaO{sup 2+}, indicating that D[Pa{sup 2+}-O] {ge} 751 kJ mol{sup -1}. A particularly notable finding was the oxidation of PaO{sup 2+} by N{sub 2}O to PaO{sub 2}{sup 2+}, a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO{sub 2}{sup 2+} suggested the protactinyl connectivity, {l_brace}O-Pa-O{r_brace}{sup 2+}. The experimentally determined IE[PaO{sub 2}{sup +}] {approx} 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO{sub 2}{sup +} and PaO{sub 2}{sup 2+}. These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial '6p hole' in the case of protactinyl. It was found that PaO{sub 2}{sup 2+} catalyzes the oxidation of CO by N{sub 2}O - such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO{sub 2}{sup 2+} is capable of activating H{sub 2} to form the stable PaO{sub 2}H{sup 2+} ion.

  3. Two Views on Performance Contracting.

    ERIC Educational Resources Information Center

    Lurie, Sylvia; Smith, Kenneth

    1996-01-01

    North Chicago, Illinois, District 187, received a districtwide overhaul of lighting, heating, ventilation, and security systems through a 10-year performance contract with the Honeywell Corporation. The Briarcliff Manor Union-Free School District, New York, has a contract with Johnson Controls that guarantees a portion of the energy savings…

  4. CONTRACT ADMINISTRATIVE TRACKING SYSTEM (CATS)

    EPA Science Inventory

    The Contract Administrative Tracking System (CATS) was developed in response to an ORD NHEERL, Mid-Continent Ecology Division (MED)-recognized need for an automated tracking and retrieval system for Cost Reimbursable Level of Effort (CR/LOE) Contracts. CATS is an Oracle-based app...

  5. Contract Education: A Background Paper.

    ERIC Educational Resources Information Center

    California Community Colleges, Sacramento. Academic Senate.

    Today contract education is generally thought of as a program or course for which an employer is paying the full cost of instruction for customized training. Contract education can help faculty remain current, encourage industry to make equipment available to the college that might otherwise be too expensive, and provide employment opportunities…

  6. Teaching History via Learning Contracts.

    ERIC Educational Resources Information Center

    Burke, Jack D.; And Others

    Contract learning is particularly suitable for teaching both the content and methodology of history in a college level, learner-centered, individualized format. Typically, a learning contract has three components. The first deals with the student's goals and objectives. The second component involves identification of the learning resources and…

  7. Contract Schools. Trends and Issues.

    ERIC Educational Resources Information Center

    Hadderman, Margaret

    This article examines contract schools and their influence on U.S. education. Schools that are contracted out may be viewed as a privatization development that both parallels and builds upon the charter-school movement. They can be defined as publicly funded schools operated by an independent group of teachers and administrators under a contract…

  8. Policing Mechanisms in Agricultural Contracts

    ERIC Educational Resources Information Center

    Wolf, Steven; Hueth, Brent; Ligon, Ethan

    2001-01-01

    In this paper we focus on mechanisms of coordination in agricultural contracts. Our approach is intended to advance understanding of social relations of production and distribution of power in agrofood systems. Through an analysis of contracts between farmers and intermediaries (e.g., processors, shippers, consignment agents) for California fruits…

  9. Contracting Arrangements in Children's Services.

    ERIC Educational Resources Information Center

    Ainsworth, Frank

    1994-01-01

    Reports on the results of a study undertaken in Pennsylvania and Massachusetts in 1992 of the use of contracting arrangements in children's services. Highlights the positive and negative aspects of contracting for both contractors and providers, and discusses the impact of this approach for the traditional differentiation between nongovernmental…

  10. Women's weekend in ninth year. PinnacleHealth, Harrisburg, PA.

    PubMed

    Herreria, J

    1997-01-01

    For nine years, PinnacleHealth has lured busy women in the Harrisburg, Pa., area away for a weekend of pampering. It's a project of PinnacleHealth's WomanCare's Resource Center. The program began with 239 women, last year the event drew 400 participants. PMID:10174494

  11. 77 FR 45240 - Establishment of Class E Airspace; Quakertown, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... Quakertown, PA (77 FR 30438) Docket No. FAA-2012-0386. Interested parties were invited to participate in this... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory...

  12. 78 FR 48296 - Amendment of Class E Airspace; Factoryville, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Field Airport, Factoryville, PA, (78 FR, 32212). Interested parties were invited to participate in this... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of...

  13. 78 FR 48297 - Amendment of Class E Airspace; Bedford, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... proposed rulemaking (NPRM) to amend Class E airspace at Bedford County Airport, Bedford, PA. (78 FR 32213...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...

  14. 77 FR 16669 - Establishment of Class E Airspace; Bellefonte, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... surface at Bellefonte, PA (76 FR 79564). Interested parties were invited to participate in this rulemaking... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) ] does not warrant preparation of...

  15. 76 FR 64234 - Establishment of Class E Airspace; Palmyra, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... (NPRM) to amend Class E airspace 700 feet above the surface, at Palmyra, PA (76 FR 49390). Interested.... 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory...

  16. Existence under PA's Charter School Law: First Year Reports.

    ERIC Educational Resources Information Center

    Johnson, Addie M.

    This paper provides an update on how some new charter schools have fared during the first year of operation under Pennsylvania's charter school legislation (PA Act 22, June 1997). Data should facilitate an examination of the degree to which the legislation supports or inhibits the entrepreneurial school reform practice of charter schools. Twenty…

  17. 78 FR 12806 - Pennsylvania Disaster Number PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00057 AGENCY: U.S. Small Business Administration. ] ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for...

  18. 76 FR 20233 - Revocation of Class E Airspace; Kutztown, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation... TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Revocation of Class E Airspace; Kutztown, PA...

  19. 76 FR 70528 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the...

  20. 76 FR 70527 - Pennsylvania Disaster Number PA-00042

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00042 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the...

  1. 76 FR 61130 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for...

  2. 76 FR 68803 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for...

  3. 78 FR 26243 - Amendment of Class E Airspace; Easton, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... Federal Register a notice of proposed rulemaking (NPRM) to amend Class E airspace at Easton, PA (78 FR... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The...

  4. 76 FR 66110 - Pennsylvania Disaster Number PA-00045

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00045 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for...

  5. 76 FR 63700 - Pennsylvania Disaster Number PA-00043

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00043 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for...

  6. 76 FR 66110 - Pennsylvania Disaster Number PA-00045

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00045 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for...

  7. 76 FR 66110 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... From the Federal Register Online via the Government Publishing Office ] SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for...

  8. 78 FR 73580 - Pennsylvania Disaster Number PA-00065

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-06

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00065 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for...

  9. 76 FR 72994 - Pennsylvania Disaster Number PA-00045

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00045 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for...

  10. 75 FR 44994 - Pennsylvania Disaster Number PA-00031

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-30

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00031 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for...

  11. 76 FR 59179 - Pennsylvania Disaster Number PA-00043

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00043 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for...

  12. Final report on bilateral comparison EURAMET.M.P-S10: Calibration of a SRG between 0.005 Pa and 1 Pa, and of a CDG between 0.5 Pa and 100 Pa

    NASA Astrophysics Data System (ADS)

    Medina, Nieves

    2011-01-01

    Two national primary laboratories, CENAM (Mexico) and CEM (Spain), have compared the results of their pressure measurement capabilities by means of the calibration of a spinning rotor gauge (SRG) between 0.005 Pa and 1 Pa, and of a capacitance digital gauge (CDG) between 0.5 Pa and 100 Pa. The results of two calibrations made by CEM make it possible to conclude that the pressure transducers used for the comparison were appropriate for the purpose. The conclusions of supplementary comparison EURAMET.M.P-S10 are that all measurements are consistent and that there is agreement between the laboratories in the range compared. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by EURAMET, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  13. ANALYSIS OF ATMOSPHERE DEPOSITION SAMPLES FROM EASTON, PA

    EPA Science Inventory

    The report gives results of an analysis of samples of tenacious atmospheric deposits on exposed surfaces (e.g., automobiles and houses) in an industrial area near Easton, PA. The analysis was made at the request of the State of Pennsylvania. The Pennsylvania Department of Environ...

  14. Transmission resonance spectroscopy in the third minimum of 232Pa

    NASA Astrophysics Data System (ADS)

    Csige, L.; Csatlós, M.; Faestermann, T.; Gulyás, J.; Habs, D.; Hertenberger, R.; Hunyadi, M.; Krasznahorkay, A.; Maier, H. J.; Thirolf, P. G.; Wirth, H.-F.

    2012-05-01

    The fission probability of 232Pa was measured as a function of the excitation energy in order to search for hyperdeformed (HD) transmission resonances using the (d,pf) transfer reaction on a radioactive 231Pa target. The experiment was performed at the Tandem accelerator of the Maier-Leibnitz Laboratory (MLL) at Garching using the 231Pa(d,pf) reaction at a bombarding energy of Ed=12 MeV and with an energy resolution of ΔE=5.5 keV. Two groups of transmission resonances have been observed at excitation energies of E*=5.7 and 5.9 MeV. The fine structure of the resonance group at E*=5.7 MeV could be interpreted as overlapping rotational bands with a rotational parameter characteristic to a HD nuclear shape (ℏ2/2Θ=2.10±0.15 keV). The fission barrier parameters of 232Pa have been determined by fitting talys 1.2 nuclear reaction code calculations to the overall structure of the fission probability. From the average level spacing of the J=4 states, the excitation energy of the ground state of the third minimum has been deduced to be EIII=5.05-0.10+0.40 MeV.

  15. 75 FR 67911 - Amendment of Class E Airspace; Jeannette, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Jeannette, PA...

  16. 76 FR 59503 - Establishment of Class E Airspace; Lebanon, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... proposed rulemaking to amend Class E airspace 700 feet above the surface, at Lebanon, PA (76 FR 39038... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p....

  17. Landsat 6 contract signed

    NASA Astrophysics Data System (ADS)

    Maggs, William Ward

    A new agreement provides $220 million for development and construction of the Landsat 6 remote sensing satellite and its ground systems. The contract, signed on March 31, 1988, by the Department of Commerce (DOC) and the Earth Observation Satellite (EOSAT) Company of Lanham, Md., came just days after approval of DOC's Landsat commercialization plan by subcommittees of the House and Senate appropriations committees.The Landsat 6 spacecraft is due to be launched into orbit on a Titan II rocket in June 1991 from Vandenburg Air Force Base, Calif. The satellite will carry an Enhanced Thematic Mapper (ETM) sensor, an instrument sensitive to electromagnetic radiation in seven ranges or bands of wavelengths. The satellite's payload will also include the Sea Wide Field Sensor (Sea-WiFS), designed to provide information on sea surface temperature and ocean color. The sensor is being developed in a cooperative effort by EOSAT and the National Aeronautics and Space Administration (NASA). A less certain passenger is a proposed 5-m resolution, three-band sensor sensitive to visible light. EOSAT is trying to find both private financing for the device and potential buyers of the high-resolution imagery that it could produce. The company has been actively courting U.S. television networks, which have in the past used imagery from the European Système Probatoire d'Observation de la Terre (SPOT) satellite for news coverage.

  18. INFINITY construction contract signed

    NASA Technical Reports Server (NTRS)

    2010-01-01

    Key state and community leaders celebrated April 6 with the signing of a construction contract for the state-of-the-art INFINITY Science Center planned near John C. Stennis Space Center in south Mississippi. Gulfport Mayor George Schloegel (l to r), chair of non-profit INFINITY Science Center Inc., was joined for the signing ceremony at the Hancock Bank in Gulfport by Virginia Wagner, sister of late Hancock Bank President Leo Seal Jr.; and Roy Anderson III, president and CEO of Roy Anderson Corp. Seal was the first chair of INFINITY Science Center Inc., which has led in development of the project. Roy Anderson Corp. plans to begin construction on the 72,000-square-foot, $28 million science and education center in May. The Mississippi Department of Transportation (MDOT) also is set to begin construction of a $2 million access road to the new center. The April 6 ceremony was attended by numerous officials, including former Stennis Space Center Directors Jerry Hlass and Roy Estess; Mississippi Senate President Pro Tempore Billy Hewes, R-Gulfport; Mississippi Rep. Diane Peranich, D-Pass Christian; and MDOT Southern District Commissioner Wayne Brown.

  19. Mechanobiology of lymphatic contractions.

    PubMed

    Munn, Lance L

    2015-02-01

    The lymphatic system is responsible for controlling tissue fluid pressure by facilitating flow of lymph (i.e. the plasma and cells that enter the lymphatic system). Because lymph contains cells of the immune system, its transport is not only important for fluid homeostasis, but also immune function. Lymph drainage can occur via passive flow or active pumping, and much research has identified the key biochemical and mechanical factors that affect output. Although many studies and reviews have addressed how tissue properties and fluid mechanics (i.e. pressure gradients) affect lymph transport [1-3] there is less known about lymphatic mechanobiology. As opposed to passive mechanical properties, mechanobiology describes the active coupling of mechanical signals and biochemical pathways. Lymphatic vasomotion is the result of a fascinating system affected by mechanical forces exerted by the flowing lymph, including pressure-induced vessel stretch and flow-induced shear stresses. These forces can trigger or modulate biochemical pathways important for controlling the lymphatic contractions. Here, I review the current understanding of lymphatic vessel function, focusing on vessel mechanobiology, and summarize the prospects for a comprehensive understanding that integrates the mechanical and biomechanical control mechanisms in the lymphatic system.

  20. 48 CFR 3443.106 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contract clause. 3443.106 Section 3443.106 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS 3443.106 Contract clause. The contracting officer shall...

  1. 48 CFR 1532.908 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clauses. 1532.908 Section 1532.908 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Prompt Payment 1532.908 Contract clauses. The Contracting...

  2. 48 CFR 1516.603 - Letter Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Letter Contracts. 1516.603 Section 1516.603 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts...

  3. 48 CFR 1532.111 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clauses. 1532.111 Section 1532.111 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING General 1532.111 Contract clauses. The Contracting Officer...

  4. 29 CFR 4.190 - Contract cancellation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., the contract is subject upon written notice to cancellation by the contracting agency, whereupon the... contract is similarly subject upon written notice to immediate cancellation by the contracting agency and... in paragraph (a). Such contract is without warrant of law and has no force and effect and is void...

  5. 7 CFR 1780.61 - Construction contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 12 2013-01-01 2013-01-01 false Construction contracts. 1780.61 Section 1780.61..., Constructing and Inspections § 1780.61 Construction contracts. Contract documents must be sufficiently.... (a) Standard construction contract documents. If the construction contract documents utilized are...

  6. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  7. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  8. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  9. 48 CFR 317.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  10. 48 CFR 46.314 - Transportation contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Transportation contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.314 Transportation contracts. The contracting officer shall insert the clause at 52.246-14, Inspection of Transportation, in solicitations and contracts for...

  11. 48 CFR 46.314 - Transportation contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Transportation contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.314 Transportation contracts. The contracting officer shall insert the clause at 52.246-14, Inspection of Transportation, in solicitations and contracts for...

  12. 48 CFR 46.314 - Transportation contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Transportation contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.314 Transportation contracts. The contracting officer shall insert the clause at 52.246-14, Inspection of Transportation, in solicitations and contracts for...

  13. 48 CFR 46.314 - Transportation contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Transportation contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.314 Transportation contracts. The contracting officer shall insert the clause at 52.246-14, Inspection of Transportation, in solicitations and contracts for...

  14. 48 CFR 46.314 - Transportation contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Transportation contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.314 Transportation contracts. The contracting officer shall insert the clause at 52.246-14, Inspection of Transportation, in solicitations and contracts for...

  15. 48 CFR 1235.7000 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in all solicitations and contracts for research and development. For further information, see...

  16. 48 CFR 46.312 - Construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Construction contracts. 46... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.312 Construction contracts. The contracting officer shall insert the clause at 52.246-12, Inspection of Construction, in solicitations and contracts...

  17. 7 CFR 631.14 - Contract violations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Contract violations. 631.14 Section 631.14 Agriculture... AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.14 Contract violations. Contract violations, determinations and appeals will be handled in accordance with the terms of...

  18. 7 CFR 631.14 - Contract violations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Contract violations. 631.14 Section 631.14 Agriculture... AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.14 Contract violations. Contract violations, determinations and appeals will be handled in accordance with the terms of...

  19. 7 CFR 631.14 - Contract violations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Contract violations. 631.14 Section 631.14 Agriculture... AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.14 Contract violations. Contract violations, determinations and appeals will be handled in accordance with the terms of...

  20. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  1. 48 CFR 1235.7000 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in all solicitations and contracts for research and development. For further information, see...

  2. 48 CFR 1832.705 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract clauses. 1832.705 Section 1832.705 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 1832.705 Contract clauses....

  3. 48 CFR 1832.705 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contract clauses. 1832.705 Section 1832.705 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 1832.705 Contract clauses....

  4. 48 CFR 1832.705 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clauses. 1832.705 Section 1832.705 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 1832.705 Contract clauses....

  5. 48 CFR 1832.705 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contract clauses. 1832.705 Section 1832.705 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 1832.705 Contract clauses....

  6. 48 CFR 1832.705 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract clauses. 1832.705 Section 1832.705 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 1832.705 Contract clauses....

  7. 48 CFR 1817.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... discuss planned future assessment of continued performance either prior to exercise of options or at the... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option periods) applies to all NASA contracts regardless of type and...

  8. 48 CFR 546.312 - Construction contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that...

  9. 7 CFR 1780.61 - Construction contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 12 2012-01-01 2012-01-01 false Construction contracts. 1780.61 Section 1780.61..., Constructing and Inspections § 1780.61 Construction contracts. Contract documents must be sufficiently.... (a) Standard construction contract documents. If the construction contract documents utilized are...

  10. 7 CFR 1780.61 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true Construction contracts. 1780.61 Section 1780.61..., Constructing and Inspections § 1780.61 Construction contracts. Contract documents must be sufficiently.... (a) Standard construction contract documents. If the construction contract documents utilized are...

  11. 48 CFR 546.312 - Construction contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that...

  12. 48 CFR 46.312 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Construction contracts. 46... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.312 Construction contracts. The contracting officer shall insert the clause at 52.246-12, Inspection of Construction, in solicitations and contracts...

  13. 48 CFR 46.312 - Construction contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Construction contracts. 46... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.312 Construction contracts. The contracting officer shall insert the clause at 52.246-12, Inspection of Construction, in solicitations and contracts...

  14. 48 CFR 546.312 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that...

  15. 48 CFR 546.312 - Construction contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that...

  16. 7 CFR 1780.61 - Construction contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false Construction contracts. 1780.61 Section 1780.61..., Constructing and Inspections § 1780.61 Construction contracts. Contract documents must be sufficiently.... (a) Standard construction contract documents. If the construction contract documents utilized are...

  17. 48 CFR 46.312 - Construction contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Construction contracts. 46... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.312 Construction contracts. The contracting officer shall insert the clause at 52.246-12, Inspection of Construction, in solicitations and contracts...

  18. Draft Genome Sequences of Pseudomonas fluorescens Strains PA4C2 and PA3G8 and Pseudomonas putida PA14H7, Three Biocontrol Bacteria against Dickeya Phytopathogens

    PubMed Central

    Cigna, Jérémy; Raoul des Essarts, Yannick; Mondy, Samuel; Hélias, Valérie; Beury-Cirou, Amélie

    2015-01-01

    Pseudomonas fluorescens strains PA4C2 and PA3G8 and Pseudomonas putida strain PA14H7 were isolated from potato rhizosphere and show an ability to inhibit the growth of Dickeya phytopathogens. Here, we report their draft genome sequences, which provide a basis for understanding the molecular mechanisms involved in antibiosis against Dickeya. PMID:25635023

  19. Draft Genome Sequences of Pseudomonas fluorescens Strains PA4C2 and PA3G8 and Pseudomonas putida PA14H7, Three Biocontrol Bacteria against Dickeya Phytopathogens.

    PubMed

    Cigna, Jérémy; Raoul des Essarts, Yannick; Mondy, Samuel; Hélias, Valérie; Beury-Cirou, Amélie; Faure, Denis

    2015-01-29

    Pseudomonas fluorescens strains PA4C2 and PA3G8 and Pseudomonas putida strain PA14H7 were isolated from potato rhizosphere and show an ability to inhibit the growth of Dickeya phytopathogens. Here, we report their draft genome sequences, which provide a basis for understanding the molecular mechanisms involved in antibiosis against Dickeya.

  20. Active contraction of microtubule networks

    PubMed Central

    Foster, Peter J; Fürthauer, Sebastian; Shelley, Michael J; Needleman, Daniel J

    2015-01-01

    Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the large-scale behaviors of these systems. Here, we investigate the self-organization of stabilized microtubules in Xenopus oocyte extracts and find that they can form macroscopic networks that spontaneously contract. We propose that these contractions are driven by the clustering of microtubule minus ends by dynein. Based on this idea, we construct an active fluid theory of network contractions, which predicts a dependence of the timescale of contraction on initial network geometry, a development of density inhomogeneities during contraction, a constant final network density, and a strong influence of dynein inhibition on the rate of contraction, all in quantitative agreement with experiments. These results demonstrate that the motor-driven clustering of filament ends is a generic mechanism leading to contraction. DOI: http://dx.doi.org/10.7554/eLife.10837.001 PMID:26701905

  1. 48 CFR 35.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... contracts as designs become more firmly established, risks are reduced, and production tooling, equipment... cost estimate for price negotiations. (See 16.207.) (e) Projects having production requirements as...

  2. 48 CFR 35.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... contracts as designs become more firmly established, risks are reduced, and production tooling, equipment... cost estimate for price negotiations. (See 16.207.) (e) Projects having production requirements as...

  3. 48 CFR 35.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... contracts as designs become more firmly established, risks are reduced, and production tooling, equipment... cost estimate for price negotiations. (See 16.207.) (e) Projects having production requirements as...

  4. 48 CFR 35.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... contracts as designs become more firmly established, risks are reduced, and production tooling, equipment... cost estimate for price negotiations. (See 16.207.) (e) Projects having production requirements as...

  5. 48 CFR 35.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... contracts as designs become more firmly established, risks are reduced, and production tooling, equipment... cost estimate for price negotiations. (See 16.207.) (e) Projects having production requirements as...

  6. 77 FR 54937 - International Mail Postal Contract

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... (2) asks the Commission to include the new contract within the International Business Reply Service... Functionally Equivalent International Business Reply Service Competitive Contract 3 Negotiated Settlement... COMMISSION International Mail Postal Contract AGENCY: Postal Regulatory Commission. ACTION: Notice....

  7. 77 FR 76091 - International Mail Contract

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... an expired International Business Reply Service (IBRS) competitive contract.\\1\\ The Postal Service... history. The Commission added International Business Reply Service Contract 1 to the competitive product... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission...

  8. Utility Energy Services Contracts: Enabling Documents

    SciTech Connect

    2009-05-01

    Utility Energy Services Contracts: Enabling Documents provides materials that clarify the authority for Federal agencies to enter into utility energy services contracts (UESCs), as well as sample documents and resources to ease utility partnership contracting.

  9. 48 CFR 8.1103 - Contract requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Leasing of Motor Vehicles 8.1103 Contract requirements. Contracting officers shall include the following items in each contract for leasing motor vehicles: (a) Scope... services....

  10. 48 CFR 8.1103 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Leasing of Motor Vehicles 8.1103 Contract requirements. Contracting officers shall include the following items in each contract for leasing motor vehicles: (a) Scope... services....

  11. 14 CFR 1274.508 - Contract administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., conditions and specifications of the contract. ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Contract administration. 1274.508 Section... WITH COMMERCIAL FIRMS Procurement Standards § 1274.508 Contract administration. A system for...

  12. 48 CFR 871.212 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SUPPLEMENTARY REGULATIONS LOAN GUARANTY AND VOCATIONAL REHABILITATION AND EMPLOYMENT PROGRAMS Vocational Rehabilitation and Employment Service 871.212 Contract clauses. Contracting officers must use the following clauses, as appropriate, in solicitations and contracts for vocational rehabilitation and...

  13. 48 CFR 871.212 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SUPPLEMENTARY REGULATIONS LOAN GUARANTY AND VOCATIONAL REHABILITATION AND EMPLOYMENT PROGRAMS Vocational Rehabilitation and Employment Service 871.212 Contract clauses. Contracting officers must use the following clauses, as appropriate, in solicitations and contracts for vocational rehabilitation and...

  14. 7 CFR 1469.21 - Contract requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CONSERVATION SECURITY PROGRAM Contracts and... conservation stewardship contract and comply with its provisions. Among other provisions, the participant... payments from one conservation stewardship contract. (c) CSP participants must address the...

  15. 7 CFR 1469.21 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CONSERVATION SECURITY PROGRAM Contracts and... conservation stewardship contract and comply with its provisions. Among other provisions, the participant... payments from one conservation stewardship contract. (c) CSP participants must address the...

  16. 7 CFR 1469.21 - Contract requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CONSERVATION SECURITY PROGRAM Contracts and... conservation stewardship contract and comply with its provisions. Among other provisions, the participant... payments from one conservation stewardship contract. (c) CSP participants must address the...

  17. Contracts in radiology practices: contract types and key provisions.

    PubMed

    Muroff, Julie A; Muroff, Lawrence R

    2004-07-01

    A contract between a radiology group and its physician member(s) provides the foundation for the professional relationships in a group practice. The parties are not in positions of parity; contract provisions are structured to maintain the primacy of the group over the individual members. An integration clause should be included to preclude reliance on communications that are not memorialized by the language of the contract. Precise, unambiguous terms must be used to convey the intentions of the parties. The contract should have a clear date of initiation and, if applicable, an effective date of termination. Mechanisms for termination and modification should be expressed clearly to minimize the risk of judicial interference. The method of determining and adjusting the salary and other benefits of the radiologist should be stated, as consideration is necessary to support the existence of a legal contract. The obligations of the radiologist to the practice are often stated in general terms to maximize the group's flexibility. Finally, other key clauses that are discussed in the paper should be incorporated into the contract.

  18. 42 CFR 434.10 - Contracts with fiscal agents.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS CONTRACTS Contracts with Fiscal Agents and Private Nonmedical Institutions § 434.10 Contracts with fiscal agents. Contracts with fiscal agents must— (a) Meet...

  19. 42 CFR 434.10 - Contracts with fiscal agents.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS CONTRACTS Contracts with Fiscal Agents and Private Nonmedical Institutions § 434.10 Contracts with fiscal agents. Contracts with fiscal agents must— (a) Meet...

  20. 42 CFR 434.10 - Contracts with fiscal agents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS CONTRACTS Contracts with Fiscal Agents and Private Nonmedical Institutions § 434.10 Contracts with fiscal agents. Contracts with fiscal agents must— (a) Meet...

  1. 48 CFR 1315.209 - Solicitation provisions and contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... COMMERCE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 1315.209 Solicitation provisions and contract clauses. The designee authorized...

  2. 32 CFR 701.7 - Relationship between the FOIA and PA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Relationship between the FOIA and PA. 701.7...) Program § 701.7 Relationship between the FOIA and PA. Not all requesters are knowledgeable of the... released under the FOIA, the PA does not bar its disclosure. Unlike the FOIA, the PA applies only to...

  3. 76 FR 44986 - Stewartstown Railroad Company; Adverse Abandonment; In York County, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... Surface Transportation Board Stewartstown Railroad Company; Adverse Abandonment; In York County, PA On... an approximately 7.4-mile line of railroad (Line) in York County, Pa., extending from milepost 0.0 at New Freedom, Pa., to milepost 7.4 at Stewartstown, Pa. The Line is owned by the Stewartstown...

  4. [Patient safety in management contracts].

    PubMed

    Campillo-Artero, C

    2012-01-01

    Patient safety is becoming commonplace in management contracts. Since our experience in patient safety still falls short of other clinical areas, it is advisable to review some of its characteristics in order to improve its inclusion in these contracts. In this paper opinions and recommendations concerning the design and review of contractual clauses on safety are given, as well as reflections drawn from methodological papers and informal opinions of clinicians, who are most familiar with the nuances of safe and unsafe practices. After reviewing some features of these contracts, criteria for prioritizing and including safety objectives and activities in them, and key points for their evaluation are described. The need to replace isolated activities by systemic and multifaceted ones is emphasized. Errors, limitations and improvement opportunities observed when contracts are linked to indicators, information and adverse event reporting systems are analysed. Finally, the influence of the rules of the game, and clinicians behaviour are emphasised.

  5. Smooth Sailing with Contract Services.

    ERIC Educational Resources Information Center

    Fickes, Michael

    2001-01-01

    Discusses how to make the contract services relationship work smoothly for educational facilities. Covers topics of food, child care, and transportation services, along with a brief explanation of the benefits of outsourcing on-campus amenities. (GR)

  6. Commerical Remote Sensing Data Contract

    USGS Publications Warehouse

    ,

    2005-01-01

    The U. S. Geological Survey's (USGS) Commercial Remote Sensing Data Contracts (CRSDCs) provide government agencies with access to a broad range of commercially available remotely sensed airborne and satellite data. These contracts were established to support The National Map partners, other Federal Civilian agency programs, and Department of Defense programs that require data for the United States and its territories. Experience shows that centralized procurement of remotely sensed data leads to considerable cost savings to the Federal government through volume discounts, reduction of redundant contract administrative costs, and avoidance of duplicate purchases. These contracts directly support the President's Commercial Remote Sensing Space Policy, signed in 2003, by providing a centralized mechanism for civil agencies to acquire commercial remote sensing products to support their mission needs in an efficient and coordinated way. CRSDC administration is provided by the USGS Mid-Continent Mapping Center in Rolla, Missouri.

  7. 48 CFR 1809.670 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Contractor Team Arrangements 1809.670 Contract... solicitations and contracts to clarify a contractor team arrangement where the prime contractor consists of...

  8. 48 CFR 801.602 - Contracting officers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DEPARTMENT OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and... contracting authority. (7) Manage and enhance career development of the procurement work force. (8)...

  9. 48 CFR 801.602 - Contracting officers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... DEPARTMENT OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and... contracting authority. (7) Manage and enhance career development of the procurement work force. (8)...

  10. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  11. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  12. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  13. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  14. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  15. Maximising value from PFI contracts.

    PubMed

    Prosser, Karen; Gates, Russell

    2012-05-01

    Against a backdrop where the Coalition Government has said more 'value' needs to be squeezed out of existing healthcare PFI projects, Karen Prosser, head of the health sector team at built asset consultancy, EC Harris, and Russell Gates, one of the company's partners on the same team, set out some of the key elements that NHS Trusts with operational PFI contracts should consider when undertaking a contract savings review.

  16. A new antithrombogenic RV-PA valved conduit.

    PubMed

    Ichikawa, Y; Noishiki, Y; Soma, T; Ishii, M; Yamamoto, K; Takahashi, K; Mo, M; Kosuge, T; Kondo, J; Matsumoto, A

    1994-01-01

    A new antithrombogenic right ventricular (RV)-pulmonary artery (PA) valved conduit was developed using a bovine jugular vein containing a natural valve. To maintain the natural and mechanical properties of the venous tissue, a hydrophilic cross-linking reagent, glycerol polyglycidyl ether polyepoxy compound (PC) was used instead of glutaraldehyde (GA). Moreover, to induce antithrombogenicity, heparin was bonded to the inner surface of the bovine jugular vein cross-linked with PC. Conduits of 18 to 20 mm inner diameter (ID) were implanted between the RV and PA in nine dogs weighing 7-17 kg, with the native main PA being ligated proximally. The handling and suturing of the graft was easy and adaptable, and the anastomosis was completed with excellent coaptation and no blood leakage at the suture lines. All animals were chronic survivors, but one animal died of hematemesis on the 438th postoperative day. Grafts were explanted from 182 to 385 days after implantation. The luminal surface of the conduits were white, glistening, and smooth with good coaptation of the cusps, without calcification or degenerative changes except for one cusp that showed a minimal deformation with a small thrombus. Macroscopic and microscopic observation showed that there were no thrombi at the anastomotic lines, but small thrombi on the luminal surface of the conduits near the cusps and in some cusps. Endothelium-like cells were noticed on the luminal surface of the graft, except in the area near the cusps, and on one cusp at 196 days after surgery. These results indicated that the new RV-PA valved conduit provided adequate antithrombogenicity by temporary slow heparin release, followed later by endothelialization of the graft in a low pressure system at 1 year after implantation. PMID:8555607

  17. Metlab Plant-Wide Assessment (Metlab in Wyndmoor, PA)

    SciTech Connect

    2002-08-01

    This OIT BestPractices case study describes the methods and results of a plant-wide energy assessment at Metlab's aircraft component manufacturing plant in Wyndmoor, PA. Recommendations derived from the assessment, if implemented, can save an estimated $528,400 annually, reduce natural gas use by 50,070 MMbtu per year, and reduce electrical use by 329,400 kWh per year.

  18. Demonstration Assessment of LED Roadway Lighting: Philadelphia, PA

    SciTech Connect

    Royer, Michael P.; Tuenge, Jason R.; Poplawski, Michael E.

    2012-09-01

    For this demonstration assessment, 10 different groups of LED luminaires were installed at three sites in Philadelphia, PA. Each of the three sites represented a different set of conditions, most importantly with regard to the incumbent HPS luminaires, which were nominally 100 W, 150 W, and 250 W. The performance of each product was evaluated based on manufacturer data, illuminance calculations, field measurements of illuminance, and the subjective impressions of both regular and expert observers.

  19. Dry powder nitroimidazopyran antibiotic PA-824 aerosol for inhalation.

    PubMed

    Sung, Jean C; Garcia-Contreras, Lucila; Verberkmoes, Jarod L; Peloquin, Charles A; Elbert, Katharina J; Hickey, Anthony J; Edwards, David A

    2009-04-01

    We formulated PA-824, a nitroimidazopyran with promise for the treatment of tuberculosis, for efficient aerosol delivery to the lungs in a dry powder porous particle form. The objectives of this study were to prepare and characterize a particulate form of PA-824, assess the stability of this aerosol formulation under different environmental conditions, and determine the pharmacokinetic parameters for the powder after pulmonary administration. The drug was spray dried into porous particles containing a high drug load and possessing desirable aerosol properties for efficient deposition in the lungs. The physical, aerodynamic, and chemical properties of the dry powder were stable at room temperature for 6 months and under refrigerated conditions for at least 1 year. Pharmacokinetic parameters were determined in guinea pigs after the pulmonary administration of the PA-824 powder formulation at three doses (20, 40, and 60 mg/kg of body weight) and compared to those after the intravenous (20 mg/kg) and oral (40 mg/kg) delivery of the drug. Oral and inhaled delivery of PA-824 achieved equivalent systemic delivery at the same body dose within the first 12 h of dosing. However, animals dosed by the pulmonary route showed drug loads that remained locally in the lungs for 32 h postexposure, whereas those given the drug orally cleared the drug more rapidly. Therefore, we expect from these pharmacokinetic data that pulmonary delivery may achieve the same efficacy as oral delivery at the same body dose, with a potential improvement in efficacy related to pulmonary infection. This may translate into the ability to deliver lower body doses of this drug for the treatment of tuberculosis by aerosol.

  20. PA-30 Twin Comanche - NASA 808 in flight

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Dryden Flight Research Center's Piper PA-30 Twin Commanche, which helped validate the RPRV concept, descends to a remotely controlled landing on Rogers Dry Lake, unassisted by the onboard pilot. A Piper PA-30 Twin Commanche, known as NASA 808, was used at the NASA Dryden Flight Research Center as a rugged workhorse in a variety of research projects associated with both general aviation and military projects. In the early 1970s, the PA-30, serial number 301498, was used to test a flight technique used to fly Remotely Piloted Research Vehicles (RPRV's). The technique was first tested with the cockpit windows of the light aircraft blacked out while the pilot flew the aircraft utilizing a television monitor which gave him a 'pilot's eye' view ahead of the aircraft. Later pilots flew the aircraft from a ground cockpit, a procedure used with all RPRV's. TV and two-way telemetry allow the pilot to be in constant control of the aircraft. The apparatus mounted over the cockpit is a special fish eye lens camera, used to obtain images that are transmitted to the ground based cockpit. This project paved the way for sophisticated, highly successful research programs involving high risk spin, stall, and flight control conditions, such as the HiMAT and the subscale F-15 remotely piloted vehicles. Over the years, NASA 808 has also been used for spin and stall research related to general aviation aircraft and also research to alleviate wake vortices behind large jetliners.

  1. PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa.

    PubMed

    Tan, Hao; Zhang, Lu; Weng, Yuding; Chen, Ronghao; Zhu, Feng; Jin, Yongxin; Cheng, Zhihui; Jin, Shouguang; Wu, Weihui

    2016-01-01

    Pseudomonas aeruginosa causes acute and chronic infections in human. Its increasing resistance to antibiotics requires alternative treatments that are more effective than available strategies. Among the alternatives is the unconventional usage of conventional antibiotics, of which the macrolide antibiotic azithromycin (AZM) provides a paradigmatic example. AZM therapy is associated with a small but consistent improvement in respiratory function of cystic fibrosis patients suffering from chronic P. aeruginosa infection. Besides immunomodulating activities, AZM represses bacterial genes involved in virulence, quorum sensing, biofilm formation, and motility, all of which are due to stalling of ribosome and depletion of cellular tRNA pool. However, how P. aeruginosa responds to and counteracts the effects of AZM remain elusive. Here, we found that deficiency of PA3297, a gene encoding a DEAH-box helicase, intensified AZM-mediated bacterial killing, suppression of pyocyanin production and swarming motility, and hypersusceptibility to hydrogen peroxide. We demonstrated that expression of PA3297 is induced by the interaction between AZM and ribosome. Importantly, mutation of PA3297 resulted in elevated levels of unprocessed 23S-5S rRNA in the presence of AZM, which might lead to increased susceptibility to AZM-mediated effects. Our results revealed one of the bacterial responses in counteracting the detrimental effects of AZM. PMID:27014238

  2. Pardes and PaRDeS: towards a psychotherapeutic theory.

    PubMed

    Rotenberg, M

    1994-01-01

    The Hebrew term Pardes has two meanings in Jewish study: the Paradise entered by four eminent Rabbis in search of mystical truth, and PaRDeS, four levels of interpreting Biblical texts. By combining the legend of Pardes with the hermeneutic system of PaRDeS, a psychological theory is presented as a set of propositions which endeavor to demonstrate the following: 1) The combination of Pardes and PaRDeS may be used as a bridge between the rational and mystic approaches to life and death. 2) The rational and the mystic stages each contain two phases: the negative break and the positive possibility of the symbolic "forty years old" more mature active remedy. 3) The "Acher-Akiva" and the "Ben Zoma-Ben Azai" dimensions do not necessarily represent four psychological personality types, but rather inner psychological struggles which may be experienced by one person in part or in full during different phases of his or her life cycle. The successful resolution of these inner psychological struggles may be facilitated by people's ability and motivation to find their one or more personally suitable "faces" from the "seventy" that are available for them. Thus, the road to "Pardes-paradise" is paved by people's own intentions.

  3. PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa

    PubMed Central

    Tan, Hao; Zhang, Lu; Weng, Yuding; Chen, Ronghao; Zhu, Feng; Jin, Yongxin; Cheng, Zhihui; Jin, Shouguang; Wu, Weihui

    2016-01-01

    Pseudomonas aeruginosa causes acute and chronic infections in human. Its increasing resistance to antibiotics requires alternative treatments that are more effective than available strategies. Among the alternatives is the unconventional usage of conventional antibiotics, of which the macrolide antibiotic azithromycin (AZM) provides a paradigmatic example. AZM therapy is associated with a small but consistent improvement in respiratory function of cystic fibrosis patients suffering from chronic P. aeruginosa infection. Besides immunomodulating activities, AZM represses bacterial genes involved in virulence, quorum sensing, biofilm formation, and motility, all of which are due to stalling of ribosome and depletion of cellular tRNA pool. However, how P. aeruginosa responds to and counteracts the effects of AZM remain elusive. Here, we found that deficiency of PA3297, a gene encoding a DEAH-box helicase, intensified AZM-mediated bacterial killing, suppression of pyocyanin production and swarming motility, and hypersusceptibility to hydrogen peroxide. We demonstrated that expression of PA3297 is induced by the interaction between AZM and ribosome. Importantly, mutation of PA3297 resulted in elevated levels of unprocessed 23S-5S rRNA in the presence of AZM, which might lead to increased susceptibility to AZM-mediated effects. Our results revealed one of the bacterial responses in counteracting the detrimental effects of AZM. PMID:27014238

  4. Thermal degradation of PA66 during laser transmission welding

    NASA Astrophysics Data System (ADS)

    Wang, Xiao; Guo, Dehui; Chen, Guochun; Jiang, Hairong; Meng, Dongdong; Yan, Zhang; Liu, Huixia

    2016-09-01

    The thermal degradation of materials strongly influences the weld strength in laser transmission welding (LTW). Weld strength decreases at high temperatures because of material thermal degradation. Hence, it is necessary to investigate this phenomenon. Thermal degradation of polyamide 66 (PA66) was predicted by combining a pyrolysis kinetic model with a 3-D transient thermal model. Thermogravimetric analysis (TGA) was used to study the pyrolysis characteristic of PA66. The TGA data were used to obtain kinetic parameters of PA66 using an nth order model in MATLAB. In addition, material conversion as a function of temperature (time) was analyzed using this kinetic reaction model containing the relevant kinetic parameters. A 3-D transient thermal model based on a volumetric heat source was developed. The temperature-time data of the point located at the maximum temperature was predicted through this thermal analysis model under different weld parameters. This study demonstrates that the predicted power at which the material starts to degrade is generally consistent with the power at which shear strength begins to decrease. The present studies lay a theoretical foundation for the investigation of thermal degradation during LTW.

  5. The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA

    PubMed Central

    Bavagnoli, Laura; Cucuzza, Stefano; Campanini, Giulia; Rovida, Francesca; Paolucci, Stefania; Baldanti, Fausto; Maga, Giovanni

    2015-01-01

    The PA protein of Influenza A virus (IAV) encoded by segment 3 acts as a specialized RNA endonuclease in the transcription of the viral genome. The same genomic segment encodes for a second shorter protein, termed PA-X, with the first 191 N-terminal aminoacids (aa) identical to PA, but with a completely different C-ter domain of 61 aa, due to a ribosomal frameshifting. In addition, it has been shown that several IAV isolates encode for a naturally truncated PA-X variant, PAXΔC20, missing the last 20 aa. The biochemical properties of PA-X and PAXΔC20 have been poorly investigated so far. Here, we have carried out an enzymatic characterization of PA-X and its naturally deleted form, in comparison with PA from the human IAV strain A/WSN/33 (H1N1). Our results showed, to the best of our knowledge for the first time, that PA-X possesses an endonucleolytic activity. Both PA and PA-X preferentially cut single stranded RNA regions, but with some differences. In addition, we showed that PAXΔC20 has severely reduced nuclease activity. These results point to a previously undetected role of the last C-ter 20 aa for the catalytic activity of PA-X and support distinct roles for these proteins in the viral life cycle. PMID:26384413

  6. The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA.

    PubMed

    Bavagnoli, Laura; Cucuzza, Stefano; Campanini, Giulia; Rovida, Francesca; Paolucci, Stefania; Baldanti, Fausto; Maga, Giovanni

    2015-10-30

    The PA protein of Influenza A virus (IAV) encoded by segment 3 acts as a specialized RNA endonuclease in the transcription of the viral genome. The same genomic segment encodes for a second shorter protein, termed PA-X, with the first 191 N-terminal aminoacids (aa) identical to PA, but with a completely different C-ter domain of 61 aa, due to a ribosomal frameshifting. In addition, it has been shown that several IAV isolates encode for a naturally truncated PA-X variant, PAXΔC20, missing the last 20 aa. The biochemical properties of PA-X and PAXΔC20 have been poorly investigated so far. Here, we have carried out an enzymatic characterization of PA-X and its naturally deleted form, in comparison with PA from the human IAV strain A/WSN/33 (H1N1). Our results showed, to the best of our knowledge for the first time, that PA-X possesses an endonucleolytic activity. Both PA and PA-X preferentially cut single stranded RNA regions, but with some differences. In addition, we showed that PAXΔC20 has severely reduced nuclease activity. These results point to a previously undetected role of the last C-ter 20 aa for the catalytic activity of PA-X and support distinct roles for these proteins in the viral life cycle.

  7. 48 CFR 1529.401 - Domestic contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Domestic contracts. 1529.401 Section 1529.401 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL CONTRACTING REQUIREMENTS TAXES Contract Clauses 1529.401 Domestic contracts....

  8. 48 CFR 1847.7001 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CONTRACT MANAGEMENT TRANSPORTATION Protection of the Florida Manatee 1847.7001 Contract clause. The contracting officer shall insert the clause at 1852.247-71, Protection of the Florida Manatee, in... the contract will involve use of waterways inhabited by manatees. The clause shall also be included...

  9. 48 CFR 1847.7001 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CONTRACT MANAGEMENT TRANSPORTATION Protection of the Florida Manatee 1847.7001 Contract clause. The contracting officer shall insert the clause at 1852.247-71, Protection of the Florida Manatee, in... the contract will involve use of waterways inhabited by manatees. The clause shall also be included...

  10. 48 CFR 1847.7001 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CONTRACT MANAGEMENT TRANSPORTATION Protection of the Florida Manatee 1847.7001 Contract clause. The contracting officer shall insert the clause at 1852.247-71, Protection of the Florida Manatee, in... the contract will involve use of waterways inhabited by manatees. The clause shall also be included...

  11. 48 CFR 1847.7001 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CONTRACT MANAGEMENT TRANSPORTATION Protection of the Florida Manatee 1847.7001 Contract clause. The contracting officer shall insert the clause at 1852.247-71, Protection of the Florida Manatee, in... the contract will involve use of waterways inhabited by manatees. The clause shall also be included...

  12. 48 CFR 1847.7001 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACT MANAGEMENT TRANSPORTATION Protection of the Florida Manatee 1847.7001 Contract clause. The contracting officer shall insert the clause at 1852.247-71, Protection of the Florida Manatee, in... the contract will involve use of waterways inhabited by manatees. The clause shall also be included...

  13. 48 CFR 13.404 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... AND CONTRACT TYPES SIMPLIFIED ACQUISITION PROCEDURES Fast Payment Procedure 13.404 Contract clause. The contracting officer shall insert the clause at 52.213-1, Fast Payment Procedure, in solicitations and contracts when the conditions in 13.402 are applicable and it is intended that the fast...

  14. 48 CFR 13.404 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... AND CONTRACT TYPES SIMPLIFIED ACQUISITION PROCEDURES Fast Payment Procedure 13.404 Contract clause. The contracting officer shall insert the clause at 52.213-1, Fast Payment Procedure, in solicitations and contracts when the conditions in 13.402 are applicable and it is intended that the fast...

  15. 48 CFR 13.404 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AND CONTRACT TYPES SIMPLIFIED ACQUISITION PROCEDURES Fast Payment Procedure 13.404 Contract clause. The contracting officer shall insert the clause at 52.213-1, Fast Payment Procedure, in solicitations and contracts when the conditions in 13.402 are applicable and it is intended that the fast...

  16. 48 CFR 13.404 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... AND CONTRACT TYPES SIMPLIFIED ACQUISITION PROCEDURES Fast Payment Procedure 13.404 Contract clause. The contracting officer shall insert the clause at 52.213-1, Fast Payment Procedure, in solicitations and contracts when the conditions in 13.402 are applicable and it is intended that the fast...

  17. 48 CFR 13.404 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... AND CONTRACT TYPES SIMPLIFIED ACQUISITION PROCEDURES Fast Payment Procedure 13.404 Contract clause. The contracting officer shall insert the clause at 52.213-1, Fast Payment Procedure, in solicitations and contracts when the conditions in 13.402 are applicable and it is intended that the fast...

  18. 48 CFR 745.106 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MANAGEMENT GOVERNMENT PROPERTY General 745.106 Contract clauses. (a) The contracting officer shall insert the... and the contract funds were obligated under a Strategic Objective agreement (or similar agreement... required in (48 CFR) FAR 45.106 in all contracts under which the contractor will acquire property...

  19. 48 CFR 30.201 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.201 Contract requirements. Title 48 CFR 9903.201-1 (FAR appendix) describes the rules for determining whether a proposed contract or subcontract is exempt from CAS. Negotiated contracts not exempt in accordance with 48 CFR...

  20. 24 CFR 242.52 - Construction contracts.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract. A contract for the construction or substantial rehabilitation of a hospital shall be entered into by...

  1. 7 CFR 250.53 - Contract provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CFR part 250; (9) Assurance that the food service management company will comply with the storage and... Management Companies § 250.53 Contract provisions. (a) Required contract provisions in fixed-price contracts... recipient agency's fixed-price contract with a food service management company. Such provisions must also...

  2. 7 CFR 250.53 - Contract provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CFR part 250; (9) Assurance that the food service management company will comply with the storage and... Management Companies § 250.53 Contract provisions. (a) Required contract provisions in fixed-price contracts... recipient agency's fixed-price contract with a food service management company. Such provisions must also...

  3. 48 CFR 3402.201 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... GENERAL DEFINITIONS OF WORDS AND TERMS Definitions Clause 3402.201 Contract clause. The contracting officer shall insert the clause in 3452.202-1, Definitions, in all solicitations and contracts in lieu of the clause in FAR 52.202-1, except— (a) A fixed-price research and development contract that...

  4. 48 CFR 846.710 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 846.710 Section 846.710 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 846.710 Contract clauses. The contracting officer shall insert the clause...

  5. 48 CFR 546.710 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clause. 546.710 Section 546.710 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 546.710 Contract clause. The Contracting officer shall insert the clause...

  6. 48 CFR 3016.406 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....406 Contract clauses. (e)(1)(i) The contracting officer shall insert a clause substantially the same as (HSAR) 48 CFR 3052.216-71, Determination of Award Fee, in solicitations and contracts that include... CFR 3052.216-72, Performance Evaluation Plan, in all solicitations and contracts that include an...

  7. 48 CFR 1427.303 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1427.303 Section 1427.303 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts. 1427.303 Contract...

  8. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or...

  9. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or...

  10. 48 CFR 204.802 - Contract files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract files. 204.802... OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Files 204.802 Contract files. Official contract files shall consist of— (1) Only original, authenticated or conformed copies of contractual...

  11. 48 CFR 415.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract format. 415.204 Section 415.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information...

  12. 48 CFR 1315.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract format. 1315.204 Section 1315.204 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information...

  13. 48 CFR 515.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract format. 515.204 Section 515.204 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and...

  14. 48 CFR 615.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract format. 615.204 Section 615.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information...

  15. 48 CFR 15.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract format. 15.204 Section 15.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information...

  16. 48 CFR 232.7004 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Electronic Submission and Processing of Payment Requests and Receiving Reports 232.7004 Contract clause. Except as provided in 232.7002(a... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause....

  17. 48 CFR 36.609 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 36.609 Section 36.609 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 36.609 Contract clauses....

  18. 48 CFR 436.609 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contract clauses. 436.609 Section 436.609 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Service 436.609 Contract clauses....

  19. 7 CFR 634.25 - Contracting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... participant must enter into an RCWP contract to treat water quality problems not covered by the joint... AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.25 Contracting... agrees to apply his or her water-quality plan. Any person who controls, or shares control, of the...

  20. 48 CFR 936.7101 - Construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Construction contracts... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Inspection and Acceptance 936.7101 Construction contracts. (a) Inspection services may be performed by the architect-engineer responsible for...

  1. 24 CFR 242.52 - Construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract. A contract for the construction or substantial rehabilitation of a hospital shall be entered into by...

  2. 48 CFR 846.312 - Construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Construction contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.312 Construction contracts. The contracting officer shall insert the clause at 852.236-74, 852.236-74, Inspection of construction, in solicitations and...

  3. 31 CFR 575.326 - Executory contract.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Executory contract. 575.326 Section 575.326 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....326 Executory contract. The term executory contract means a contract which cannot be...

  4. 7 CFR 631.14 - Contract violations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contract violations. 631.14 Section 631.14 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.14 Contract...

  5. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contracts. 631.10 Section 631.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a)...

  6. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Contracts. 631.10 Section 631.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a)...

  7. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Contracts. 631.10 Section 631.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a)...

  8. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Contracts. 631.10 Section 631.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a)...

  9. 7 CFR 631.14 - Contract violations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Contract violations. 631.14 Section 631.14 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.14 Contract...

  10. 48 CFR 2439.107 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract clauses. 2439.107 Section 2439.107 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY 2439.107 Contract clauses. (a) The contracting officer shall insert...

  11. 48 CFR 2446.710 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Performance Specifications or Design Criteria, whenever it is in the Government's interest. ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clauses. 2446.710... CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 2446.710 Contract clauses. (c)(1) The contracting...

  12. 48 CFR 745.106 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MANAGEMENT GOVERNMENT PROPERTY General 745.106 Contract clauses. (a) The contracting officer shall insert the... and the contract funds were obligated under a Strategic Objective agreement (or similar agreement... required in (48 CFR) FAR 45.106 in all contracts under which the contractor will acquire property...

  13. 48 CFR 745.106 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MANAGEMENT GOVERNMENT PROPERTY General 745.106 Contract clauses. (a) The contracting officer shall insert the... and the contract funds were obligated under a Strategic Objective agreement (or similar agreement... required in (48 CFR) FAR 45.106 in all contracts under which the contractor will acquire property...

  14. 48 CFR 745.106 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MANAGEMENT GOVERNMENT PROPERTY General 745.106 Contract clauses. (a) The contracting officer shall insert the... and the contract funds were obligated under a Strategic Objective agreement (or similar agreement... required in (48 CFR) FAR 45.106 in all contracts under which the contractor will acquire property...

  15. 48 CFR 745.106 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MANAGEMENT GOVERNMENT PROPERTY General 745.106 Contract clauses. (a) The contracting officer shall insert the... and the contract funds were obligated under a Strategic Objective agreement (or similar agreement... required in (48 CFR) FAR 45.106 in all contracts under which the contractor will acquire property...

  16. 48 CFR 30.201 - Contract requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.201 Contract requirements. Title 48 CFR 9903.201-1 (FAR appendix) describes the rules for determining whether a proposed contract or subcontract is exempt from CAS. Negotiated contracts not exempt in accordance with 48 CFR...

  17. 48 CFR 927.303 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts 927.303 Contract clauses... (but see (FAR) 48 CFR 27.304-3 regarding contracts for construction work or architect-engineer services... Government, in all such contracts other than those described in paragraphs (a)(2) and (a)(3) of this...

  18. 36 CFR 1008.8 - Government contracts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Government contracts. 1008.8 Section 1008.8 Parks, Forests, and Public Property PRESIDIO TRUST REQUESTS UNDER THE PRIVACY ACT § 1008.8 Government contracts. (a) Required contract provisions. When a contract provides for the operation by or...

  19. 36 CFR 1008.8 - Government contracts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Government contracts. 1008.8 Section 1008.8 Parks, Forests, and Public Property PRESIDIO TRUST REQUESTS UNDER THE PRIVACY ACT § 1008.8 Government contracts. (a) Required contract provisions. When a contract provides for the operation by or...

  20. 36 CFR 1008.8 - Government contracts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Government contracts. 1008.8 Section 1008.8 Parks, Forests, and Public Property PRESIDIO TRUST REQUESTS UNDER THE PRIVACY ACT § 1008.8 Government contracts. (a) Required contract provisions. When a contract provides for the operation by or...

  1. 36 CFR 1008.8 - Government contracts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Government contracts. 1008.8 Section 1008.8 Parks, Forests, and Public Property PRESIDIO TRUST REQUESTS UNDER THE PRIVACY ACT § 1008.8 Government contracts. (a) Required contract provisions. When a contract provides for the operation by or...

  2. 36 CFR 1008.8 - Government contracts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Government contracts. 1008.8 Section 1008.8 Parks, Forests, and Public Property PRESIDIO TRUST REQUESTS UNDER THE PRIVACY ACT § 1008.8 Government contracts. (a) Required contract provisions. When a contract provides for the operation by or...

  3. 48 CFR 546.312 - Construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Construction contracts. 546.312 Section 546.312 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause...

  4. 24 CFR 242.52 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract. A contract for the construction or substantial rehabilitation of a hospital shall be entered into by...

  5. 48 CFR 936.7101 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Construction contracts... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Inspection and Acceptance 936.7101 Construction contracts. (a) Inspection services may be performed by the architect-engineer responsible for...

  6. 48 CFR 846.312 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Construction contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.312 Construction contracts. The contracting officer shall insert the clause at 852.236-74, 852.236-74, Inspection of construction, in solicitations and...

  7. 24 CFR 242.52 - Construction contracts.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract. A contract for the construction or substantial rehabilitation of a hospital shall be entered into by...

  8. Psychological contracts of hospice nurses.

    PubMed

    Jones, Audrey Elizabeth; Sambrook, Sally

    2010-12-01

    Psychological contracts have been described as individuals' beliefs regarding the obligations, expectations, and contributions that exist between them and their employer. They can be influenced by the organization's culture and philosophy, through human resources policies, and through the employee's personality and characteristics. Owing to the recent economic crisis, hospices in the UK are currently in a transitional phase and are being expected to demonstrate efficiencies that might be more in line with a business model than a health-care environment. This may conflict with the philosophical views of hospice nurses. To support nurses through this transition, it might be helpful to understand the antecedents of hospice nurses' behaviour and how they construct their psychological contracts. Failure to offer adequate support might lead to negative outcomes such as a desire to leave the organisation, poorer quality work, or disruptive behaviour. This study used a modified grounded theory approach involving in-depth interviews to explore the context and content of the psychological contracts of hospice nurses in the UK. Four main themes emerged: the types of psychological contracts formed, how the contracts are formed, their contents, and the breaches and potential violations the nurses perceive. PMID:21240104

  9. Experimental Results on Jets in pA

    NASA Astrophysics Data System (ADS)

    Appelt, Eric

    2015-04-01

    The experimentally observed reduction of jet yields in ultrarelativistic heavy ion (AA) collisions relative to proton-proton (pp) collisions is widely interpreted in terms of energy loss of a hard scattered parton traversing a quark-gluon plasma (QGP) before fragmenting into a jet of hadrons. In order to constrain proposed mechanisms of energy loss, a variety of measurements are needed that quantify both how the jet yields and jet structure are modified in the medium. However, jets may also be modified by differences in the initial state of the nucleus relative to that of the proton. The precise determination of the QGP properties relies on disentangling these additional modifications, collectively termed ``cold nuclear matter'' effects, from energy loss in the QGP. Collisions between heavy ions and protons (pA) provide a potential control environment where cold nuclear matter effects should be present, but QGP formation is generally not expected to occur. In this talk, an overview of recent jet results from proton-lead collisions produced at the LHC will be given. The yield of inclusive jets and distributions of dijet pairs are shown to be compatible with generally accepted theoretical expectations, although significant modification is observed when yields are measured from specific centrality classes of pA collision events. Some measurements of high-pT charged hadron yields suggest a larger modification in pA collisions relative to pp collisions than for inclusive jet yields. The potential implications of this difference along with other measurements relating to jet structure will be discussed.

  10. Atomic Mass and Nuclear Binding Energy for Pa-273 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-273 (Protactinium, atomic number Z = 91, mass number A = 273).

  11. Atomic Mass and Nuclear Binding Energy for Pa-260 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-260 (Protactinium, atomic number Z = 91, mass number A = 260).

  12. Atomic Mass and Nuclear Binding Energy for Pa-271 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-271 (Protactinium, atomic number Z = 91, mass number A = 271).

  13. Atomic Mass and Nuclear Binding Energy for Pa-267 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-267 (Protactinium, atomic number Z = 91, mass number A = 267).

  14. Atomic Mass and Nuclear Binding Energy for Pa-262 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-262 (Protactinium, atomic number Z = 91, mass number A = 262).

  15. Atomic Mass and Nuclear Binding Energy for Pa-281 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-281 (Protactinium, atomic number Z = 91, mass number A = 281).

  16. Atomic Mass and Nuclear Binding Energy for Pa-257 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-257 (Protactinium, atomic number Z = 91, mass number A = 257).

  17. Atomic Mass and Nuclear Binding Energy for Pa-275 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-275 (Protactinium, atomic number Z = 91, mass number A = 275).

  18. Atomic Mass and Nuclear Binding Energy for Pa-266 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-266 (Protactinium, atomic number Z = 91, mass number A = 266).

  19. Atomic Mass and Nuclear Binding Energy for Pa-285 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-285 (Protactinium, atomic number Z = 91, mass number A = 285).

  20. Atomic Mass and Nuclear Binding Energy for Pa-300 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-300 (Protactinium, atomic number Z = 91, mass number A = 300).

  1. Atomic Mass and Nuclear Binding Energy for Pa-274 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-274 (Protactinium, atomic number Z = 91, mass number A = 274).

  2. Atomic Mass and Nuclear Binding Energy for Pa-272 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-272 (Protactinium, atomic number Z = 91, mass number A = 272).

  3. Atomic Mass and Nuclear Binding Energy for Pa-255 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-255 (Protactinium, atomic number Z = 91, mass number A = 255).

  4. Atomic Mass and Nuclear Binding Energy for Pa-277 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-277 (Protactinium, atomic number Z = 91, mass number A = 277).

  5. Atomic Mass and Nuclear Binding Energy for Pa-298 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-298 (Protactinium, atomic number Z = 91, mass number A = 298).

  6. Atomic Mass and Nuclear Binding Energy for Pa-263 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-263 (Protactinium, atomic number Z = 91, mass number A = 263).

  7. Atomic Mass and Nuclear Binding Energy for Pa-252 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-252 (Protactinium, atomic number Z = 91, mass number A = 252).

  8. Atomic Mass and Nuclear Binding Energy for Pa-315 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-315 (Protactinium, atomic number Z = 91, mass number A = 315).

  9. Atomic Mass and Nuclear Binding Energy for Pa-296 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-296 (Protactinium, atomic number Z = 91, mass number A = 296).

  10. Atomic Mass and Nuclear Binding Energy for Pa-295 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-295 (Protactinium, atomic number Z = 91, mass number A = 295).

  11. Atomic Mass and Nuclear Binding Energy for Pa-293 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-293 (Protactinium, atomic number Z = 91, mass number A = 293).

  12. Atomic Mass and Nuclear Binding Energy for Pa-316 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-316 (Protactinium, atomic number Z = 91, mass number A = 316).

  13. Atomic Mass and Nuclear Binding Energy for Pa-289 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-289 (Protactinium, atomic number Z = 91, mass number A = 289).

  14. Atomic Mass and Nuclear Binding Energy for Pa-308 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-308 (Protactinium, atomic number Z = 91, mass number A = 308).

  15. Atomic Mass and Nuclear Binding Energy for Pa-247 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-247 (Protactinium, atomic number Z = 91, mass number A = 247).

  16. Atomic Mass and Nuclear Binding Energy for Pa-286 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-286 (Protactinium, atomic number Z = 91, mass number A = 286).

  17. Atomic Mass and Nuclear Binding Energy for Pa-251 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-251 (Protactinium, atomic number Z = 91, mass number A = 251).

  18. Atomic Mass and Nuclear Binding Energy for Pa-294 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-294 (Protactinium, atomic number Z = 91, mass number A = 294).

  19. Atomic Mass and Nuclear Binding Energy for Pa-287 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-287 (Protactinium, atomic number Z = 91, mass number A = 287).

  20. Atomic Mass and Nuclear Binding Energy for Pa-301 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-301 (Protactinium, atomic number Z = 91, mass number A = 301).

  1. Atomic Mass and Nuclear Binding Energy for Pa-261 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-261 (Protactinium, atomic number Z = 91, mass number A = 261).

  2. Atomic Mass and Nuclear Binding Energy for Pa-288 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-288 (Protactinium, atomic number Z = 91, mass number A = 288).

  3. Atomic Mass and Nuclear Binding Energy for Pa-249 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-249 (Protactinium, atomic number Z = 91, mass number A = 249).

  4. Atomic Mass and Nuclear Binding Energy for Pa-264 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-264 (Protactinium, atomic number Z = 91, mass number A = 264).

  5. Atomic Mass and Nuclear Binding Energy for Pa-297 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-297 (Protactinium, atomic number Z = 91, mass number A = 297).

  6. Atomic Mass and Nuclear Binding Energy for Pa-305 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-305 (Protactinium, atomic number Z = 91, mass number A = 305).

  7. Atomic Mass and Nuclear Binding Energy for Pa-304 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-304 (Protactinium, atomic number Z = 91, mass number A = 304).

  8. Atomic Mass and Nuclear Binding Energy for Pa-280 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-280 (Protactinium, atomic number Z = 91, mass number A = 280).

  9. Atomic Mass and Nuclear Binding Energy for Pa-253 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-253 (Protactinium, atomic number Z = 91, mass number A = 253).

  10. Atomic Mass and Nuclear Binding Energy for Pa-265 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-265 (Protactinium, atomic number Z = 91, mass number A = 265).

  11. Atomic Mass and Nuclear Binding Energy for Pa-268 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-268 (Protactinium, atomic number Z = 91, mass number A = 268).

  12. Atomic Mass and Nuclear Binding Energy for Pa-278 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-278 (Protactinium, atomic number Z = 91, mass number A = 278).

  13. Atomic Mass and Nuclear Binding Energy for Pa-279 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-279 (Protactinium, atomic number Z = 91, mass number A = 279).

  14. Atomic Mass and Nuclear Binding Energy for Pa-284 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-284 (Protactinium, atomic number Z = 91, mass number A = 284).

  15. Atomic Mass and Nuclear Binding Energy for Pa-302 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-302 (Protactinium, atomic number Z = 91, mass number A = 302).

  16. Atomic Mass and Nuclear Binding Energy for Pa-256 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-256 (Protactinium, atomic number Z = 91, mass number A = 256).

  17. Atomic Mass and Nuclear Binding Energy for Pa-259 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-259 (Protactinium, atomic number Z = 91, mass number A = 259).

  18. Atomic Mass and Nuclear Binding Energy for Pa-292 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-292 (Protactinium, atomic number Z = 91, mass number A = 292).

  19. Atomic Mass and Nuclear Binding Energy for Pa-283 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-283 (Protactinium, atomic number Z = 91, mass number A = 283).

  20. Atomic Mass and Nuclear Binding Energy for Pa-291 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-291 (Protactinium, atomic number Z = 91, mass number A = 291).

  1. Atomic Mass and Nuclear Binding Energy for Pa-254 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-254 (Protactinium, atomic number Z = 91, mass number A = 254).

  2. Atomic Mass and Nuclear Binding Energy for Pa-276 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-276 (Protactinium, atomic number Z = 91, mass number A = 276).

  3. Atomic Mass and Nuclear Binding Energy for Pa-248 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-248 (Protactinium, atomic number Z = 91, mass number A = 248).

  4. Atomic Mass and Nuclear Binding Energy for Pa-269 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-269 (Protactinium, atomic number Z = 91, mass number A = 269).

  5. Atomic Mass and Nuclear Binding Energy for Pa-303 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-303 (Protactinium, atomic number Z = 91, mass number A = 303).

  6. Atomic Mass and Nuclear Binding Energy for Pa-306 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-306 (Protactinium, atomic number Z = 91, mass number A = 306).

  7. Atomic Mass and Nuclear Binding Energy for Pa-299 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-299 (Protactinium, atomic number Z = 91, mass number A = 299).

  8. Atomic Mass and Nuclear Binding Energy for Pa-307 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-307 (Protactinium, atomic number Z = 91, mass number A = 307).

  9. Atomic Mass and Nuclear Binding Energy for Pa-314 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-314 (Protactinium, atomic number Z = 91, mass number A = 314).

  10. Atomic Mass and Nuclear Binding Energy for Pa-258 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-258 (Protactinium, atomic number Z = 91, mass number A = 258).

  11. Atomic Mass and Nuclear Binding Energy for Pa-270 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-270 (Protactinium, atomic number Z = 91, mass number A = 270).

  12. Atomic Mass and Nuclear Binding Energy for Pa-250 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-250 (Protactinium, atomic number Z = 91, mass number A = 250).

  13. Atomic Mass and Nuclear Binding Energy for Pa-282 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-282 (Protactinium, atomic number Z = 91, mass number A = 282).

  14. Atomic Mass and Nuclear Binding Energy for Pa-290 (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Pa-290 (Protactinium, atomic number Z = 91, mass number A = 290).

  15. Incentive contracts for development projects

    NASA Astrophysics Data System (ADS)

    Finley, David T.; Smith, Byron; DeGroff, B.

    2012-09-01

    Finding a contract vehicle that balances the concerns of the customer and the contractor in a development project can be difficult. The customer wants a low price and an early delivery, with as few surprises as possible as the project progresses. The contractor wants sufficient cost and schedule to cover risk. Both want to clearly define what each party will provide. Many program offices do not want to award cost plus contracts because their funding sources will not allow it, their boards do not want an open ended commitment, and they feel like they lose financial control of the project. A fixed price incentive contract, with a mutually agreed upon target cost, provides the owner with visibility into the project and input into the execution of the project, encourages both parties to save costs, and stimulates a collaborative atmosphere by aligning the respective interests of customers and contractors.

  16. What are the factors associated with physical activity (PA) participation in community dwelling adults with dementia? A systematic review of PA correlates.

    PubMed

    Stubbs, Brendon; Eggermont, Laura; Soundy, Andrew; Probst, Michel; Vandenbulcke, Mathieu; Vancampfort, Davy

    2014-01-01

    PA shows promise as a modifiable lifestyle intervention to benefit pathological symptoms of dementia. However, little is known about the factors associated with participation in PA in community dwelling adults with dementia. A systematic review was undertaken to identify PA correlates. Two independent reviewers searched major electronic databases and extracted data on studies reporting quantitative correlates of PA participation in community dwelling adults with dementia. PA correlates were analyzed using the summary code approach within the socio-ecological model. Out of a potential of 118 articles, 12 met the eligibility criteria encompassing 752 participants. We conducted secondary analysis on nine data sets. Increased energy intake, resting metabolic rate, fat free mass, gait speed, global motor function, overall health related quality of life (HRQOL), physical HRQOL, higher levels of social functioning and reduced apathy were positively associated with PA. Taking ≥ four medications, dizziness, lower activities of daily living (ADL) function, a history of falls, less waking hours in the day, more autonomic problems and delirium were negatively associated with PA. Increasing age and lower global cognition were not consistently associated with PA participation. It is surprising that increasing age and lower global cognition do not appear to influence PA participation. All significant correlates should be confirmed in prospective studies with particular focus on the relationship of PA and gait speed, ADL function, falls history and dietary intake and the progression of frailty and nursing home admission as a priority.

  17. 24 CFR 983.206 - HAP contract amendments (to add or substitute contract units).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false HAP contract amendments (to add or... Contract § 983.206 HAP contract amendments (to add or substitute contract units). (a) Amendment to... substitute unit and must determine the reasonable rent for such unit. (b) Amendment to add contract units....

  18. 24 CFR 983.206 - HAP contract amendments (to add or substitute contract units).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false HAP contract amendments (to add or... Contract § 983.206 HAP contract amendments (to add or substitute contract units). (a) Amendment to... substitute unit and must determine the reasonable rent for such unit. (b) Amendment to add contract units....

  19. 78 FR 13706 - Public Availability of FY 2011 Service Contract Inventory Analysis, FY 2012 Service Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... COMMISSION Public Availability of FY 2011 Service Contract Inventory Analysis, FY 2012 Service Contract Inventory, and FY 2012 Service Contract Inventory Planned Analysis for the U.S. International Trade... Service Contract Inventory Analysis, the FY 2012 Service Contract Inventory, and the FY 2012...

  20. 17 CFR Appendix B to Part 43 - Enumerated Physical Commodity Contracts and Other Contracts

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Contracts and Other Contracts B Appendix B to Part 43 Commodity and Securities Exchanges COMMODITY FUTURES... Commodity Contracts and Other Contracts Enumerated Physical Commodity Contracts Agriculture ICE Futures U.S. Cocoa ICE Futures U.S. Coffee C Chicago Board of Trade Corn ICE Futures U.S. Cotton No. 2 ICE Futures...

  1. 48 CFR 1335.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... research involving human subjects to be carried out in performance of the award is exempt from15 CFR Part... Subjects, that the research involving human subjects is not exempt from the requirements of 15 CFR Part 27... contract type. 1335.006 Section 1335.006 Federal Acquisition Regulations System DEPARTMENT OF...

  2. To Contract or Not to Contract Is Not the Question.

    ERIC Educational Resources Information Center

    Rush, Sean C.; And Others

    1994-01-01

    A 10-step process is outlined for college decision makers assessing the feasibility of self-operation, contract management, or some combination of these for management of a specific service or function. The role of the governing board in decision making and acceptance of ultimate responsibility for success is also discussed. (MSE)

  3. 48 CFR 616.203-4 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 616.203-4 Contract clauses. Contracting... maintenance, and gardening). Posts shall obtain A/OPE approval for any price adjustment clause that...

  4. 48 CFR 232.703 - Contract funding requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contract funding... SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 232.703 Contract funding requirements....

  5. Processing of FENDL-PA/1.1

    SciTech Connect

    Mann, F.M.; Lessor, D.E.; Carter, L.L.

    1994-02-01

    The Fusion Evaluated Nuclear Data Library (FENDL) is an evaluated nuclear data library based upon the best evaluations from the world community. The library is maintained by the Nuclear Data Section of the International Atomic Energy Agency (IAEA). However, before the data can be used in computer codes, it must be processed into the appropriate format. The library containing the transmutation (or activation) cross sections that are part of FENDL is designated as FENDL-PA (P designating pointwise). The evaluations in Version 1.1 of this activation library were selected in the following two steps. For the most important reactions ({approximately}250), consultants to the IAEA compared evaluations submitted for consideration with experimental data. These evaluations included those from ENDF/B, JEF, BROND, JENDL, as well as ``complete`` activation libraries, such as EAF and REAC. The consultants then chose the ``best`` evaluation for each of the reactions. The evaluations for the remaining ({approximately}12,000) reactions were taken from EAF-3. The pointwise FENDL-PA/1.1 activation library was processed into two formats. Continuous energy format as used by the Monte Carlo neutron/photon transport code MCNP. ASCII 175 group multigroup format as used by the transmutation code REAC*2/3.

  6. Ginger extract inhibits biofilm formation by Pseudomonas aeruginosa PA14.

    PubMed

    Kim, Han-Shin; Park, Hee-Deung

    2013-01-01

    Bacterial biofilm formation can cause serious problems in clinical and industrial settings, which drives the development or screening of biofilm inhibitors. Some biofilm inhibitors have been screened from natural products or modified from natural compounds. Ginger has been used as a medicinal herb to treat infectious diseases for thousands of years, which leads to the hypothesis that it may contain chemicals inhibiting biofilm formation. To test this hypothesis, we evaluated ginger's ability to inhibit Pseudomonas aeruginosa PA14 biofilm formation. A static biofilm assay demonstrated that biofilm development was reduced by 39-56% when ginger extract was added to the culture. In addition, various phenotypes were altered after ginger addition of PA14. Ginger extract decreased production of extracellular polymeric substances. This finding was confirmed by chemical analysis and confocal laser scanning microscopy. Furthermore, ginger extract formed noticeably less rugose colonies on agar plates containing Congo red and facilitated swarming motility on soft agar plates. The inhibition of biofilm formation and the altered phenotypes appear to be linked to a reduced level of a second messenger, bis-(3'-5')-cyclic dimeric guanosine monophosphate. Importantly, ginger extract inhibited biofilm formation in both Gram-positive and Gram-negative bacteria. Also, surface biofilm cells formed with ginger extract detached more easily with surfactant than did those without ginger extract. Taken together, these findings provide a foundation for the possible discovery of a broad spectrum biofilm inhibitor. PMID:24086697

  7. Ginger Extract Inhibits Biofilm Formation by Pseudomonas aeruginosa PA14

    PubMed Central

    Kim, Han-Shin; Park, Hee-Deung

    2013-01-01

    Bacterial biofilm formation can cause serious problems in clinical and industrial settings, which drives the development or screening of biofilm inhibitors. Some biofilm inhibitors have been screened from natural products or modified from natural compounds. Ginger has been used as a medicinal herb to treat infectious diseases for thousands of years, which leads to the hypothesis that it may contain chemicals inhibiting biofilm formation. To test this hypothesis, we evaluated ginger’s ability to inhibit Pseudomonas aeruginosa PA14 biofilm formation. A static biofilm assay demonstrated that biofilm development was reduced by 39–56% when ginger extract was added to the culture. In addition, various phenotypes were altered after ginger addition of PA14. Ginger extract decreased production of extracellular polymeric substances. This finding was confirmed by chemical analysis and confocal laser scanning microscopy. Furthermore, ginger extract formed noticeably less rugose colonies on agar plates containing Congo red and facilitated swarming motility on soft agar plates. The inhibition of biofilm formation and the altered phenotypes appear to be linked to a reduced level of a second messenger, bis-(3′-5′)-cyclic dimeric guanosine monophosphate. Importantly, ginger extract inhibited biofilm formation in both Gram-positive and Gram-negative bacteria. Also, surface biofilm cells formed with ginger extract detached more easily with surfactant than did those without ginger extract. Taken together, these findings provide a foundation for the possible discovery of a broad spectrum biofilm inhibitor. PMID:24086697

  8. SUPPLEMENTARY COMPARISON: Negative gauge pressure comparison: range -95 kPa to +95 kPa (EURAMET Project 1131)

    NASA Astrophysics Data System (ADS)

    Rantanen, Markku; Saxholm, Sari; Altintas, Aykurt; Pavis, Richard; Peterson, Guliko

    2010-01-01

    A pressure comparison in the negative gauge pressure range was arranged in 2009. The participating laboratories were CMI/Czech Republic, FORCE Technology/Denmark, AS Metrosert/Estonia and MIKES/Finland. Negative gauge pressures are a common range for pressure calibrations although uncertainty requirements are generally not very high. The results from the four participating laboratories suggest that calibrations in the negative gauge pressure range are not as easy as expected. Some of the claimed uncertainties were perhaps too optimistic, and the large variation in the results made it difficult to generate consistent reference values. The agreement of the results at positive gauge pressures on the same transfer standard was much better. Obviously there is a need for further comparisons in the negative gauge pressure range. The transfer standard was a multifunction calibrator Beamex MC5 equipped with an internal pressure module for the range -100 kPa to 104 kPa in the gauge mode. The resolution of the display was 0.001 kPa. The stability of the transfer standard was good. The comparison was registered as EURAMET Project No. 1131 and as the supplementary comparison EURAMET.M.P-S8 in the BIPM key comparison database. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by EURAMET, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  9. Contraction-Only Exercise Machine

    NASA Technical Reports Server (NTRS)

    Doerr, Donald F.; Maples, Arthur B.; Campbell, Craig M.

    1992-01-01

    Standard knee-extension machine modified so subject experiences force only when lifting leg against stack of weights. Exerts little force on leg while being lowered. Hydraulic cylinder and reservoir mounted on frame of exercise machine. Fluid flows freely from cylinder to reservoir during contraction (lifting) but in constricted fashion from reservoir to cylinder during extension (lowering).

  10. There's Gold in Those Contracts

    ERIC Educational Resources Information Center

    Diaz, Russell

    2009-01-01

    In 2006, when the author joined the staff at Dominican College (New York), he discovered that the network, computers, and IT contracts were in sorry shape. He also found that this kind of condition is common in small colleges. Such a state of affairs is usually brought about by the unrelenting demands placed on small IT staffs. IT staffers at…

  11. CONTRACT DOCUMENTS AND PERFORMANCE SPECIFICATIONS.

    ERIC Educational Resources Information Center

    First California Commission on School Construction Systems, Palo Alto.

    A SET OF EDUCATIONAL SPECIFICATION DRAFTED BY THE FIRST CALIFORNIA COMMISSION ON SCHOOL CONSTRUCTION SYSTEMS GIVES INFORMATION ON BIDDING PROCEDURES, A DESCRIPTION OF THE CURRENT CONSTRUCTION PROGRAM, PROCEDURES FOR SUBMITTING A PROPOSAL, DATA AND CONDITIONS RELATED TO THE DEVELOPMENT PHASE OF THE PROJECT, COMPONENT CONTRACTS, AND GENERAL…

  12. SSC Test Operations Contract Overview

    NASA Technical Reports Server (NTRS)

    Kleim, Kerry D.

    2010-01-01

    This slide presentation reviews the Test Operations Contract at the Stennis Space Center (SSC). There are views of the test stands layouts, and closer views of the test stands. There are descriptions of the test stand capabilities, some of the other test complexes, the Cryogenic propellant storage facility, the High Pressure Industrial Water (HPIW) facility, and Fluid Component Processing Facility (FCPF).

  13. Jazzing up the Psychological Contract

    ERIC Educational Resources Information Center

    Hartley, Nell Tabor

    2010-01-01

    Helping students and practitioners to understand and utilize the Psychological Contract is often a difficult task. Unlike fault-finding research, this paper presents the PC as a positive, vibrant and valuable tool. In an effort to make the concept less elusive, the paper draws upon the metaphor of jazz. The metaphor is an accepted tool of…

  14. Dynamics of contracting viscoelastic filaments

    NASA Astrophysics Data System (ADS)

    Harris, Michael; Appathurai, Santosh; Bhat, Pradeep; Basaran, Osman

    2009-11-01

    Satellite drops are detrimental to many industrial applications involving the formation of viscoelastic drops including inkjet printing, DNA microarraying, and printing of flexible solar cells. The precursor to these satellite drops is a slender liquid filament that connects an about-to-form drop to the rest of the liquid in the nozzle. Once a filament is formed, it contracts due to surface tension. A filament may undergo further breakup during recoil. Whereas the contraction of Newtonian filaments in a passive ambient fluid is well understood (Schulkes 1996 and Notz and Basaran 2004), the contraction dynamics of viscoelastic filaments remains largely unexplored and is addressed in this presentation. Here the filament shape is idealized as an axisymmetric fluid cylinder terminated by hemispherical end-caps, and the conformation tensor formalism (Pasquali & Scriven 2002) is used to model the viscoelasticity. The dynamics of contracting filaments are then analyzed by means of both a well-benchmarked two-dimensional finite element algorithm (Notz et al. 2001, Chen et al. 2002) and a one-dimensional slender-jet algorithm (Padgett et al. 1996). Regions of the parameter space are identified where recoiling filaments give rise to either a single satellite drop or multiple satellites.

  15. Guide to coal contracts 1989

    SciTech Connect

    Glass, J.; Linden, M.

    1989-01-01

    The material in this book derives from the Public Utility Regulatory Policies Act of 1978 (PURPA) and Federal Energy Regulatory Commission (FERC) Form 423 data. PURPA requires FERC to monitor every two years the fuel-purchasing practices of those utilities under PURPA jurisdiction - that is, those utilities producing electricity for wholesale distribution. This includes most investor-owned utilities in the U.S. In addition, FERC requires all utilities to report monthly fuel purchases on Form 423's. The first section covers investor-owned utilities' contracts in effect during the period 1986-1987 and gives for those years the f.o.b. mines and delivered prices, contract specifications, quality as delivered, contract signature and expiration dates, the means and cost of transportation, names of the coal seam, and leaseholder and owner of mining equipment. The second section contains limited information on utilities not covered by PURPA. This section, based on summaries of FERC Form 423 data provided by RDI Inc.'s COALDAT Marketing Report, includes contracts in effect at the end of 1987 for 49 municipals and cooperatives and the Tennessee Valley Authority.

  16. 10. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  17. 11. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  18. 9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  19. HABS PA,6MTPLES.V,7 (sheet 1 of 1) Dundore Farm, State ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HABS PA,6-MTPLES.V,7- (sheet 1 of 1) - Dundore Farm, State Route 183 & Church Road vicinity, Penn Township (moved to Brownsville vicinity, Lower Heidelberg Township, Berks County), Mount Pleasant, Berks County, PA

  20. HABS PA,6MTPLES.V,13 (sheet 1 of 1) KonigSpeicher Farm, North ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HABS PA,6-MTPLES.V,13- (sheet 1 of 1) - Konig-Speicher Farm, North side of Church Road, south of Tulpehocken Creek, North Heidelberg Township (moved to Willow Street, Lenhartsville, Berks County), Mount Pleasant, Berks County, PA

  1. SOUTH ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTH ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ST-5 157.4651. Left (printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  2. SOUTH ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTH ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ST-5 157.4651. Right (not printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  3. HAER PA,48BETH,10 (sheet 3 of 5) Luckenbach Flour Mill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER PA,48-BETH,10- (sheet 3 of 5) - Luckenbach Flour Mill, 250 feet east of Monocacy Creek, 250 feet west of Main Street, 700 feet south of Broad Street, north side of Ohio Road, Bethlehem, Northampton County, PA

  4. HAER PA,48BETH,10 (sheet 5 of 5) Luckenbach Flour Mill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER PA,48-BETH,10- (sheet 5 of 5) - Luckenbach Flour Mill, 250 feet east of Monocacy Creek, 250 feet west of Main Street, 700 feet south of Broad Street, north side of Ohio Road, Bethlehem, Northampton County, PA

  5. HAER PA,48BETH,10 (sheet 2 of 5) Luckenbach Flour Mill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER PA,48-BETH,10- (sheet 2 of 5) - Luckenbach Flour Mill, 250 feet east of Monocacy Creek, 250 feet west of Main Street, 700 feet south of Broad Street, north side of Ohio Road, Bethlehem, Northampton County, PA

  6. HAER PA,48BETH,10 (sheet 1 of 5) Luckenbach Flour Mill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER PA,48-BETH,10- (sheet 1 of 5) - Luckenbach Flour Mill, 250 feet east of Monocacy Creek, 250 feet west of Main Street, 700 feet south of Broad Street, north side of Ohio Road, Bethlehem, Northampton County, PA

  7. HAER PA,48BETH,10 (sheet 4 of 5) Luckenbach Flour Mill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER PA,48-BETH,10- (sheet 4 of 5) - Luckenbach Flour Mill, 250 feet east of Monocacy Creek, 250 feet west of Main Street, 700 feet south of Broad Street, north side of Ohio Road, Bethlehem, Northampton County, PA

  8. Ammonia sensing behaviors of TiO2-PANI/PA6 composite nanofibers.

    PubMed

    Wang, Qingqing; Dong, Xianjun; Pang, Zengyuan; Du, Yuanzhi; Xia, Xin; Wei, Qufu; Huang, Fenglin

    2012-01-01

    Titanium dioxide-polyaniline/polyamide 6 (TiO(2)-PANI/PA6) composite nanofibers were prepared by in situ polymerization of aniline in the presence of PA6 nanofibers and a sputtering-deposition process with a high purity titanium sputtering target. TiO(2)-PANI/PA6 composite nanofibers and PANI/PA6 composite nanofibers were fabricated for ammonia gas sensing. The ammonia sensing behaviors of the sensors were examined at room temperature. All the results indicated that the ammonia sensing property of TiO(2)-PANI/PA6 composite nanofibers was superior to that of PANI/PA6 composite nanofibers. TiO(2)-PANI/PA6 composite nanofibers had good selectivity to ammonia. It was also found that the content of TiO(2) had a great influence on both the morphology and the sensing property of TiO(2)-PANI/PA6 composite nanofibers. PMID:23235446

  9. EAST ELEVATION, TOWER, MIDDLE LEFT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, MIDDLE LEFT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-3 157.4630. Left (printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  10. EAST ELEVATION, TOWER, MIDDLE RIGHT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, MIDDLE RIGHT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-4 157.4631. Left (printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  11. EAST ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-5 157.4632. Right (not printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  12. EAST ELEVATION, TOWER, UPPER RIGHT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, UPPER RIGHT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-6 157.4633. Left (printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  13. EAST ELEVATION, TOWER, LOWER RIGHT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, LOWER RIGHT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-2 157.4629. Right (not printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  14. EAST ELEVATION, TOWER, MIDDLE RIGHT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, MIDDLE RIGHT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-4 157.4631. Right (not printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  15. EAST ELEVATION, TOWER, LOWER LEFT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, LOWER LEFT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-1 157.4628. Left (printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  16. EAST ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, UPPER LEFT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-5 157.4632. Left (printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  17. EAST ELEVATION, TOWER, LOWER RIGHT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, LOWER RIGHT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-2 157.4629. Left (printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  18. EAST ELEVATION, TOWER, UPPER RIGHT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, UPPER RIGHT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-6 157.4633. Right (not printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  19. EAST ELEVATION, TOWER, LOWER LEFT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, LOWER LEFT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-1 157.4628. Right (not printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA

  20. EAST ELEVATION, TOWER, MIDDLE LEFT. Glass plate stereopair number PA1430139 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION, TOWER, MIDDLE LEFT. Glass plate stereopair number PA-1430-139 LC-HABS-GS05-ET-3 157.4630. Right (not printed) - Independence Hall Complex, Independence Hall, 500 Chestnut Street, Philadelphia, Philadelphia County, PA