Science.gov

Sample records for 5-ht-induced pa contraction

  1. Role of "Aplysia" Cell Adhesion Molecules during 5-HT-Induced Long-Term Functional and Structural Changes

    ERIC Educational Resources Information Center

    Han, Jin-Hee; Lim, Chae-Seok; Lee, Yong-Seok; Kandel, Eric R.; Kaang, Bong-Kiun

    2004-01-01

    We previously reported that five repeated pulses of 5-HT lead to down-regulation of the TM-apCAM isoform at the surface of "Aplysia" sensory neurons (SNs). We here examined whether apCAM down-regulation is required for 5-HT-induced long-term facilitation. We also analyzed the role of the cytoplasmic and extracellular domains by overexpressing…

  2. 42 CFR 434.6 - General requirements for all contracts and subcontracts. P>(a) Contracts. All contracts under...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... contracts and subcontracts.P>(a) Contracts. All contracts under this part must include all of the following: (1) Include provisions that define a sound and complete procurement contract, as required by 45 CFR... subcontracts. P>(a) Contracts. All contracts under this part must include all of the following: 434.6...

  3. Effects of different anticoagulants on human platelet size distribution and serotonin (5-HT) induced shape change and uptake kinetics.

    PubMed

    Malmgren, R; Beving, H; Olsson, P

    1985-06-15

    The effect of collecting blood with disodium ethylene diamine tetraacetate (EDTA), citrate (NAC) or acid sodium citrate-dextrose (ACD) as anticoagulants on platelet count and size distribution was investigated. No difference between the three preparations regarding platelet count was found in whole blood. Preparation of platelet-rich plasma (PRP) significantly reduced the platelet count in NAC-PRP (p less than 0.01) to a value of 288 X 10(9)/l compared to those of 365 X 10(9)/l and 368 X 10(9)/l in EDTA and ACD blood respectively. A significant shift in the platelet size in EDTA-PRP towards larger cell volumes was observed. There were no differences in the size distribution pattern between NAC-PRP and ACD-PRP in spite of the differences in platelet count. Platelet 5-HT uptake kinetics in EDTA-PRP showed a 50 per cent reduction in both Km and Vmax compared to that in ACD-PRP. The study shows that the receptor mediating 5-HT induced shape change has a direct opposite pH dependence than that of the 5-HT carrier. Interference of receptor-mediated responses in 5-HT uptake studies in human platelets is clearly minimized at a lowered pH. The finding is probably of importance in disorders associated with platelet hyperaggregability. PMID:3927509

  4. 5-HT induces temporomandibular joint nociception in rats through the local release of inflammatory mediators and activation of local β adrenoceptors.

    PubMed

    Oliveira-Fusaro, Maria Cláudia G; Clemente-Napimoga, Juliana Trindade; Teixeira, Juliana Maia; Torres-Chávez, Karla Elena; Parada, Carlos Amílcar; Tambeli, Cláudia Herrera

    2012-09-01

    The 5-hydroxytryptamine (serotonin, 5-HT) is an important inflammatory mediator found in high levels in the synovial fluid of the temporomandibular joint (TMJ) of patients with inflammatory pain. In this study, we used the nociceptive behavior responses, measured as flinching the head and rubbing the orofacial region, as a nociceptive assay. We demonstrated that the local blockade of the 5-HT₃ receptor and β₁ or β₂-adrenoceptors, the depletion of norepinephrine in the sympathetic terminals and the local inhibition of cyclooxygenase significantly reduced 5-HT-induced TMJ nociception. These results demonstrated that 5-HT induces nociception in the TMJ region by the activation of β₁ and β₂ adrenoceptors located in the TMJ region and local release of sympathetic amines and prostaglandins. Therefore, the high levels of 5-HT in the synovial fluid of patients with TMJ inflammatory pain may contribute to TMJ pain by similar mechanisms. PMID:22683622

  5. Naftopidil inhibits 5-hydroxytryptamine-induced bladder contraction in rats.

    PubMed

    Sakai, Takumi; Kasahara, Ken-ichi; Tomita, Ken-ichi; Ikegaki, Ichiro; Kuriyama, Hiroshi

    2013-01-30

    Naftopidil is an α(1D) and α(1A) subtype-selective α(1)-adrenoceptor antagonist that has been used to treat lower urinary tract symptoms of benign prostatic hyperplasia. In this study, we investigated the effects of naftopidil on 5-hydroxytryptamine (5-HT)-induced rat bladder contraction (10(-8)-10(-4) M). Naftopidil (0.3, 1, and 3 μM) inhibited 5-HT-induced bladder contraction in a concentration-dependent manner. On the other hand, other α(1)-adrenoceptor antagonists, tamsulosin, silodosin or prazosin, did not inhibit 5-HT-induced bladder contraction. The 5-HT-induced bladder contraction was inhibited by both ketanserin and 4-(4-fluoronaphthalen-1-yl)-6-propan-2-ylpyrimidin-2-amine (RS127445), serotonin 5-HT(2A) and 5-HT(2B) receptor antagonists, respectively. In addition, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and α-methyl-5-HT, 5-HT(2A) and 5-HT(2) receptor agonists, respectively, induced bladder contraction. The 5-HT-induced bladder contraction was not inhibited by N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-yl-cyclohexanecarboxamide (WAY-100635), [1-[2[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl-1-methyl-1H-indole-3-carboxylate (GR113808) or (R)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulphonyl]phenol (SB269970), 5-HT(1A), 5-HT(4) and 5-HT(7) receptor antagonists, respectively. Naftopidil inhibited both the 5-HT(2A) and 5-HT(2) receptor agonists-induced bladder contractions. Naftopidil binds to the human 5-HT(2A) and 5-HT(2B) receptors with pKi values of 6.55 and 7.82, respectively. These results suggest that naftopidil inhibits 5-HT-induced bladder contraction via blockade of the 5-HT(2A) and 5-HT(2B) receptors in rats. Furthermore, 5-HT-induced bladder contraction was enhanced in bladder strips obtained from bladder outlet obstructed rats, with this contraction inhibited by naftopidil. The beneficial effects of naftopidil on storage symptoms such as urinary frequency and nocturia in patients with benign

  6. Distribution of serotonin 5-HT1A-binding sites in the brainstem and the hypothalamus, and their roles in 5-HT-induced sleep and ingestive behaviors in rock pigeons (Columba livia).

    PubMed

    dos Santos, Tiago Souza; Krüger, Jéssica; Melleu, Fernando Falkenburger; Herold, Christina; Zilles, Karl; Poli, Anicleto; Güntürkün, Onur; Marino-Neto, José

    2015-12-15

    Serotonin 1A receptors (5-HT1ARs), which are widely distributed in the mammalian brain, participate in cognitive and emotional functions. In birds, 5-HT1ARs are expressed in prosencephalic areas involved in visual and cognitive functions. Diverse evidence supports 5-HT1AR-mediated 5-HT-induced ingestive and sleep behaviors in birds. Here, we describe the distribution of 5-HT1ARs in the hypothalamus and brainstem of birds, analyze their potential roles in sleep and ingestive behaviors, and attempt to determine the involvement of auto-/hetero-5-HT1ARs in these behaviors. In 6 pigeons, the anatomical distribution of [(3)H]8-OH-DPAT binding in the rostral brainstem and hypothalamus was examined. Ingestive/sleep behaviors were recorded (1h) in 16 pigeons pretreated with MM77 (a heterosynaptic 5-HT1AR antagonist; 23 or 69 nmol) for 20 min, followed by intracerebroventricular ICV injection of 5-HT (N:8; 150 nmol), 8-OH-DPAT (DPAT, a 5-HT1A,7R agonist, 30 nmol N:8) or vehicle. 5-HT- and DPAT-induced sleep and ingestive behaviors, brainstem 5-HT neuronal density and brain 5-HT content were examined in 12 pigeons, pretreated by ICV with the 5-HT neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) or vehicle (N:6/group). The distribution of brainstem and diencephalic c-Fos immunoreactivity after ICV injection of 5-HT, DPAT or vehicle (N:5/group) into birds provided with or denied access to water is also described. 5-HT1ARs are concentrated in the brainstem 5-HTergic areas and throughout the periventricular hypothalamus, preoptic nuclei and circumventricular organs. 5-HT and DPAT produced a complex c-Fos expression pattern in the 5-HT1AR-enriched preoptic hypothalamus and the circumventricular organs, which are related to drinking and sleep regulation, but modestly affected c-Fos expression in 5-HTergic neurons. The 5-HT-induced ingestivebehaviors and the 5-HT- and DPAT-induced sleep behaviors were reduced by MM77 pretreatment. 5,7-DHT increased sleep per se, decreased tryptophan

  7. Contracts

    Science.gov Websites

    05, 2016 Contracts For Feb. 04, 2016 Contracts For Feb. 03, 2016 Contracts For Feb. 02, 2016 Contracts For Feb. 01, 2016 Search Contracts Search Recent Oldest Title Title - ...

  8. Contracts

    Science.gov Websites

    2016 Contracts For March 04, 2016 Contracts For March 03, 2016 Contracts For March 02, 2016 Contracts For March 01, 2016 Search Contracts Search Recent Oldest Title Title - ...

  9. Contractions

    MedlinePlus

    ... feel tightening of your uterus muscles at irregular intervals or a squeezing sensation in your lower abdomen ... beginning of childbirth. These contractions come at regular intervals, usually move from the back to the lower ...

  10. Inhibition of native 5-HT3 receptor-evoked contractions in guinea pig and mouse ileum by antimalarial drugs.

    PubMed

    Kelley, Stephen P; Walsh, Jacqueline; Kelly, Mark C; Muhdar, Simerjyot; Adel-Aziz, Mohammed; Barrett, Iain D; Wildman, Scott S

    2014-09-01

    Quinine, chloroquine and mefloquine are commonly used to treat malaria, however, with associated gastrointestinal (GI) side-effects. These drugs act as antagonists at recombinant 5-HT3 receptors and modulate gut peristalsis. These gastrointestinal side effects may be the result of antagonism at intestinal 5-HT3 receptors. Ileum from male C57BL/6 mice and guinea pigs was mounted longitudinally in organ baths. The concentration-response curves for 5-HT and the selective 5-HT3 agonist 2-Me-5-HT were obtained with 5-HT (pEC50 = 7.57 ± 0.33, 12) more potent (P = 0.004) than 2-Me-5-HT (pEC50 = 5.45 ± 0.58, n = 5) in mouse ileum. There was no difference in potency of 5-HT (pEC50 = 5.42 ± 0.15, n = 8) and 2-Me-5-HT (pIC50 = 5.01 ± 0.55, n = 11) in guinea pig ileum (P > 0.05). Quinine, chloroquine or mefloquine was applied for 10 min and inhibitions prior to submaximal agonist application. In mouse ileum, quinine, chloroquine and mefloquine antagonised 5-HT-induced contractions (pIC50 = 4.9 ± 0.17, n = 7; 4.76 ± 0.14, n = 5; 6.21 ± 0.2, n = 4, correspondingly) with mefloquine most potent (P < 0.05). Quinine, chloroquine and mefloquine antagonised 2-me-5-HT-induced contractions (pIC50 = 6.35 ± 0.11, n = 8; 4.64 ± 0.2, n = 7; 5.11 ± 0.22, n = 6, correspondingly) with quinine most potent (P < 0.05). In guinea-pig ileum, quinine, chloroquine and mefloquine antagonised 5-HT-induced contractions (pIC50 = 5.02 ± 0.15, n = 6; 4.54 ± 0.1, n = 7; 5.32 ± 0.13, n = 5) and 2-me-5-HT-induced contractions (pIC50 = 4.62 ± 0.25, n = 5; 4.56 ± 0.14, n = 6; 5.67 ± 0.12, n = 4) with chloroquine least potent against 5-HT and mefloquine most potent against 2-me-5-HT (P < 0.05). These results support previous studies identifying anti-malarial drugs as antagonists at recombinant 5-HT3 receptors and may also demonstrate the ability of these drugs to influence native 5-HT3 receptor-evoked contractile responses which may account for their associated GI side-effects. PMID:24886883

  11. Participation of 5-HT1-like and 5-HT2A receptors in the contraction of human temporal artery by 5-hydroxytryptamine and related drugs.

    PubMed Central

    Verheggen, R.; Freudenthaler, S.; Meyer-Dulheuer, F.; Kaumann, A. J.

    1996-01-01

    1. We investigated the hypothesis that, as in some other large human arteries, 5-HT-induced contraction of the temporal artery is mediated through two co-existing receptor populations, 5-HT1-like- and 5-HT2A. Temporal arterial segments were obtained from patients undergoing brain surgery and rings prepared set up to contract with 5-HT and related agents. Fractions of maximal 5-HT responses mediated through 5-HT1-like and 5-HT2A receptors, f1 and f2 = 1-f1, were estimated by use of the 5-HT2A-selective antagonist ketanserin. 2. In rings with intact endothelium 5-HT evoked contractions with a -log EC50, M of 7.0. Ketanserin (10-1000 nM) antagonized part of the 5-HT-induced contractions. Ketanserin-resistant components of 5-HT-induced contractions were found with -log EC50, M of 6.9 and f1 of 0.17 (100 nM ketanserin) and -log EC50, M of 6.4 and f1 of 0.20 (1000 nM ketanserin). 3. In rings with endothelial function attenuated by enzymatic treatment, 5-HT caused contractions with a -log EC50, M of 7.2 that were partially blocked by ketanserin. Ketanserin-resistant components of 5-HT-induced contractions were found with -log EC50, M 7.4 and f1 of 0.16 (100 nM ketanserin) and -log EC50, M of 7.5 and f1 of 0.14 (1000 nM ketanserin). 4. The ketanserin-resistant component of 5-HT-evoked contraction was blocked by methiothepin (100-1000 nM) consistent with mediation through 5-HT1-like receptors. 5. In rings with intact endothelium the 5-HT1-like-selective agonist, sumatriptan, caused small contractions with a -log EC50, M of 6.5 and intrinsic activity of 0.21 with respect to 5-HT that were resistant to blockade by 1000 nM ketanserin but antagonized by 100 nM methiothepin. 6. In rings with intact endothelium the 5-HT2A receptor partial agonist SK&F 103829 (2,3,4,5-tetrahydro-8[methyl sulphonyl]-1H3-benzazepin-7-ol methensulphonate) contracted rings with a -log EC50, M of 5.0 and an intrinsic activity of 0.49 with respect to 5-HT; the effects were antagonized by ketanserin 1000

  12. Characterization of the 5-hydroxytryptamine receptors mediating contraction in the pig isolated intravesical ureter

    PubMed Central

    Hernández, Medardo; Barahona, María Victoria; Simonsen, Ulf; Recio, Paz; Rivera, Luis; Martínez, Ana Cristina; García-Sacristán, Albino; Orensanz, Luis M; Prieto, Dolores

    2003-01-01

    This study was designed to investigate the effect of 5-hydroxytryptamine (5-HT) and to characterize the 5-HT receptors involved in 5-HT responses in the pig intravesical ureter. 5-HT (0.01–10 μM) concentration-dependently increased the tone of intravesical ureteral strips, whereas the increases in phasic contractions were concentration-independent. The 5-HT2 receptor agonist α-methyl 5-HT, mimicked the effect on tone whereas weak or no response was obtained with 5-CT, 8-OH-DPAT, m-chlorophenylbiguanide and RS 67333, 5-HT1, 5-HT1A, 5-HT3 and 5-HT4 receptor agonists, respectively. 5-HT did not induce relaxation of U46619-contracted ureteral preparations. Pargyline (100 μM), a monoaminooxidase A/B activity inhibitor, produced leftward displacements of the concentration-response curves for 5-HT. 5-HT-induced tone was reduced by the 5-HT2 and 5-HT2A receptor antagonists ritanserine (0.1 μM) and spiperone (0.2 μM), respectively. However, 5-HT contraction was not antagonized by cyanopindolol (2 μM), SDZ–SER 082 (1 μM), Y-25130 (1 μM) and GR 113808 (0.1 μM), which are respectively, 5-HT1A/1B, 5-HT2B/2C, 5-HT3, and 5-HT4 selective receptor antagonists. Removal of the urothelium did not modify 5-HT-induced contractions. Blockade of neuronal voltage-activated sodium channels, α-adrenergic receptors and adrenergic neurotransmission with tetrodotoxin (1 μM), phentolamine (0.3 μM) and guanethidine (10 μM), respectively, reduced the contractions to 5-HT. However, physostigmine (1 μM), atropine (0.1 μM) and suramin (30 μM), inhibitors of cholinesterase activity, muscarinic- and purinergic P2-receptors, respectively, failed to modify the contractions to 5-HT. These results suggest that 5-HT increases the tone of the pig intravesical ureter through 5-HT2A receptors located at the smooth muscle. Part of the 5-HT contraction is indirectly mediated via noradrenaline release from sympathetic nerves. PMID:12522083

  13. Physician Assistant profession (PA)

    MedlinePlus

    ... provide health care services under the direction and supervision of a doctor of medicine (MD) or a ... location as the PA. Most states allow physician supervision by telephone communication with periodic site visits. Supervising ...

  14. Physician Assistant profession (PA)

    MedlinePlus

    ... and about 4 years of health-related experience. Educational programs for PAs are typically associated with colleges of medicine. They vary from 25 to 27 months in length. Most programs award a master's degree upon completion. The first PA students were ...

  15. Teaching Contracts with Contracts

    ERIC Educational Resources Information Center

    Misner, Robert L.

    1977-01-01

    The teaching of contracts law is an area that lends itself easily to introducing students to realistic factual situations. An exercise is described in which students were assigned to separate "firms" with volunteers from the later law school classes as clients. Each firm was responsible for submitting a signed contract and an accompanying paper.…

  16. Premature Contractions

    MedlinePlus

    ... Tools & Resources Stroke More Premature Contractions - PACs and PVCs Updated:Apr 6,2016 Premature contraction = early beat ... chambers of the heart (atria). Premature ventricular contractions (PVCs) start in the lower chambers of the heart ( ...

  17. PaR-PaR Laboratory Automation Platform

    SciTech Connect

    Linshiz, G; Stawski, N; Poust, S; Bi, CH; Keasling, JD; Hilson, NJ

    2013-05-01

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

  18. 48 CFR 219.806 - Pricing the 8(a) contract.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Pricing the 8(a) contract... Administration (The 8(a) Program) 219.806 Pricing the 8(a) contract. For requirements processed under the PA cited in 219.800— (1) The contracting officer shall obtain certified cost or pricing data from the...

  19. 48 CFR 219.806 - Pricing the 8(a) contract.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Pricing the 8(a) contract... Administration (The 8(a) Program) 219.806 Pricing the 8(a) contract. For requirements processed under the PA cited in 219.800— (1) The contracting officer shall obtain cost or pricing data from the 8(a)...

  20. 48 CFR 219.806 - Pricing the 8(a) contract.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Pricing the 8(a) contract... Administration (The 8(a) Program) 219.806 Pricing the 8(a) contract. For requirements processed under the PA cited in 219.800— (1) The contracting officer shall obtain certified cost or pricing data from the...

  1. 48 CFR 219.806 - Pricing the 8(a) contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Pricing the 8(a) contract... Administration (The 8(a) Program) 219.806 Pricing the 8(a) contract. For requirements processed under the PA cited in 219.800— (1) The contracting officer shall obtain cost or pricing data from the 8(a)...

  2. 48 CFR 219.806 - Pricing the 8(a) contract.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Pricing the 8(a) contract... Administration (The 8(a) Program) 219.806 Pricing the 8(a) contract. For requirements processed under the PA cited in 219.800— (1) The contracting officer shall obtain cost or pricing data from the 8(a)...

  3. Architect's Contract.

    ERIC Educational Resources Information Center

    Ohio State Board of Education, Columbus.

    An actual contract form used for architectural services is presented. Fees, duties, and services are included. Services are listed in the following phases--(1) schematic design, (2) design development, (3) contract document, and (4) construction. Extra services are listed, and owner's responsibility with regard to cost estimates is given.…

  4. Managing Contraction.

    ERIC Educational Resources Information Center

    Taylor, William

    The major thesis of this paper on declining resources and enrollment is that the management of decline, or, as the author calls it, "contraction," is not simply an economic and technical problem; it is basically a conceptual and political one. The author first considers the effects of contraction on schools, buildings, and courses, touching on the…

  5. Performance Contracting.

    ERIC Educational Resources Information Center

    Allen, Tom

    The management team at Minooka (Illinois) School District 201 is actively pursuing school improvement measures by establishing Performance Contracts to increase productivity. The format of the Performance Contract highlights yearly short-term and long-term goals, which are presented in the form of Job Improvement Targets stating the goal itself, a…

  6. Student Contracts.

    ERIC Educational Resources Information Center

    Aldridge, Hal

    1971-01-01

    Discussion of the nature of student-teacher contracts pertaining to academic work to be performed by the student and evaluated by the teacher covers a wide range of related issues in this article. The nature of contracts, evaluation procedures, instructional materials, community attitudes, and the individualization of instruction are commented on…

  7. Contracts. Warranties.

    ERIC Educational Resources Information Center

    Mertz, Gayle

    1988-01-01

    Presents two lesson plans for grades 5-9 which are meant to increase student's legal literacy. The first lesson covers contracts and includes a comic strip which illustrates contract law. The second deals with warranties and why they are important. Included are examples of product warranties. (GEA)

  8. 42 CFR 51.21 - Contracts for program operations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... individuals. (b) An eligible P&A system may contract for the operation of all or part of its program with... that the contractor has adequate management and fiscal systems in place, including insurance...

  9. Contract sanctity

    SciTech Connect

    Seeley, R.S.

    1995-10-01

    Increased competition and the pressure to keep rates low is driving utilities and independent power producers alike to consider more options to keep costs down. While an important strategy for them, the results are creating some conflicts. The April 12, 1995 Federal Energy Regulatory Commission (FERC) decision against New York State Electric & Gas (NYSEG) attempt to breach contracts with two independent power producers, observers say, is one of the most important decisions on contract disputes between independents and utilities. It reveals the complex issues and compelling arguments on both sides. It opens the question of utilities` ability to pay, and the future direction of independent power. The conflicts create a problem for utilities and independents alike.

  10. 42 CFR 51.21 - Contracts for program operations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Contracts for program operations. 51.21 Section 51.21 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS... individuals. (b) An eligible P&A system may contract for the operation of all or part of its program...

  11. 42 CFR 51.21 - Contracts for program operations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Contracts for program operations. 51.21 Section 51.21 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS... individuals. (b) An eligible P&A system may contract for the operation of all or part of its program...

  12. 42 CFR 51.21 - Contracts for program operations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Contracts for program operations. 51.21 Section 51.21 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS... individuals. (b) An eligible P&A system may contract for the operation of all or part of its program...

  13. 42 CFR 51.21 - Contracts for program operations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Contracts for program operations. 51.21 Section 51.21 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS... individuals. (b) An eligible P&A system may contract for the operation of all or part of its program...

  14. Mediation of 5-HT-induced external carotid vasodilatation in GR 127935-pretreated vagosympathectomized dogs by the putative 5-HT7 receptor

    PubMed Central

    Villalón, Carlos M; Centurión, David; Luján-Estrada, Miguel; Terrón, José A; Sánchez-López, Araceli

    1997-01-01

    The vasodilator effects of 5-hydroxytryptamine (5-HT) in the external carotid bed of anaesthetized dogs with intact sympathetic tone are mediated by prejunctional sympatho-inhibitory 5-HT1B/1D receptors and postjunctional 5-HT receptors. The prejunctional vasodilator mechanism is abolished after vagosympathectomy which results in the reversal of the vasodilator effect to vasoconstriction. The blockade of this vasoconstrictor effect of 5-HT with the 5-HT1B/1D receptor antagonist, GR 127935, unmasks a dose-dependent vasodilator effect of 5-HT, but not of sumatriptan. Therefore, the present study set out to analyse the pharmacological profile of this postjunctional vasodilator 5-HT receptor in the external carotid bed of vagosympathectomized dogs pretreated with GR 127935 (20 μg kg−1, i.v.).One-minute intracarotid (i.c.) infusions of 5-HT (0.330 μg min−1), 5-carboxamidotryptamine (5-CT; 0.010.3 μg min−1), 5-methoxytryptamine (1100 μg min−1) and lisuride (31000 μg min−1) resulted in dose-dependent increases in external carotid blood flow (without changes in blood pressure or heart rate) with a rank order of agonist potency of 5-CT>>5-HT⩾5-methoxytryptamine>lisuride, whereas cisapride (1001000 μg min−1, i.c.) was practically inactive. Interestingly, lisuride (mean dose of 85±7 μg kg−1, i.c.), but not cisapride (mean dose of 67±7 μg kg−1, i.c.), specifically abolished the responses induced by 5-HT, 5-CT and 5-methoxytryptamine, suggesting that a common site of action may be involved. In contrast, 1 min i.c. infusions of 8-OH-DPAT (33000 μg min−1) produced dose-dependent decreases, not increases, in external carotid blood flow and failed to antagonize (mean dose of 200±33 μg kg−1, i.c.) the agonist-induced vasodilator responses.The external carotid vasodilator responses to 5-HT, 5-CT and 5-methoxytryptamine were not modified by intravenous (i.v.) pretreatment with either saline, (±)-pindolol (4 mg kg−1) or ritanserin (100 μg kg−1) plus granisetron (300 μg kg−1), but were dose-dependently blocked by i.v. administration of methiothepin (10 and 30 μg kg−1, given after ritanserin plus granisetron), mesulergine (10 and 30 μg kg−1), metergoline (1 and 3 mg kg−1), methysergide (1 and 3 mg kg−1) or clozapine (0.3 and 1 mg kg−1). Nevertheless, the blockade of the above responses, not significant after treatment with the lower of the two doses of metergoline and mesulergine, was nonspecific after administration of the higher of the two doses of methysergide and clozapine.Based upon the above rank order of agonist potencies and the antagonism produced by a series of drugs showing high affinity for the cloned 5-ht7 receptor, our results indicate that the 5-HT receptor mediating external carotid vasodilatation in GR 127935-pretreated vagosympathectomized dogs is operationally similar to the putative 5-HT7 receptor mediating relaxation of vascular and non-vascular smooth muscles (e.g. rabbit femoral vein, canine coronary artery, rat systemic vasculature and guinea-pig ileum) as well as tachycardia in the cat. PMID:9105708

  15. Cluster CAA Module for PaPCo

    NASA Astrophysics Data System (ADS)

    Faden, J.; Åsnes, A.; Friedel, R.; Taylor, M.; McCaffrey, S.; Perry, C.; Goldstein, M. L.

    A PaPCo module for visualization of data from the CAA has been developed. This module retrieves data from the CAA web interface, and allows for discovery and plotting of new datasets. PaPCo is modular, open source IDL software that uses plug-in modules to bring new datasets on to a stack of time series plots (www.papco.org). PaPCo includes modules for plotting data from Cluster/PEACE and Cluster/RAPID, CDA Web data which includes Cluster Prime Parameters, and various modules from CRRES, POLAR, GPS, and many other spacecraft. The Cluster CAA module is presented, as well as a brief description of PaPCo's use and installation procedure.

  16. 78 FR 47814 - Pennsylvania Disaster # PA-00059

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00059 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY.... Small Business Administration, Processing And Disbursement Center, 14925 Kingsport Road, Fort Worth,...

  17. Oxidation of gas-phase protactinium ions, Pa+ and Pa2+: formation and properties of PaO2(2+)(g), protactinyl.

    PubMed

    Santos, Marta; de Matos, António Pires; Marçalo, Joaquim; Gibson, John K; Haire, Richard G; Tyagi, Rajni; Pitzer, Russell M

    2006-05-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N(2)O to the relatively weak CH(2)O-all oxidized Pa(+) to PaO(+) and PaO(+) to PaO(2)(+). On the basis of experimental observations, it was established that D[Pa(+)-O] and D[OPa(+)-O] > or = 751 kJ mol(-1). Estimates for D[Pa(+)-O], D[OPa(+)-O], IE[PaO], and IE[PaO(2)] were also obtained. The seven oxidants reacted with Pa(2+) to produce PaO(2+), indicating that D[Pa(2+)-O] > or = 751 kJ mol(-1). A particularly notable finding was the oxidation of PaO(2+) by N(2)O to PaO(2)(2+), a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO(2)(2+) suggested the protactinyl connectivity, {O-Pa-O}(2+). The experimentally determined IE[PaO(2)(+)] approximately 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO(2)(+) and PaO(2)(2+). These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial "6p hole" in the case of protactinyl. It was found that PaO(2)(2+) catalyzes the oxidation of CO by N(2)O-such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO(2)(2+) is capable of activating H(2) to form the stable PaO(2)H(2+) ion. PMID:16640369

  18. Functional Characterization of Phalaenopsis aphrodite Flowering Genes PaFT1 and PaFD

    PubMed Central

    Jang, Seonghoe; Choi, Sang-Chul; Li, Hsing-Yi; An, Gynheung; Schmelzer, Elmon

    2015-01-01

    We show that the key flowering regulators encoded by Phalaenopsis aphrodite FLOWERING LOCUS T1 (PaFT1) and PaFD share high sequence homologies to these from long-day flowering Arabidopsis and short-day flowering rice. Interestingly, PaFT1 is specifically up-regulated during flowering inductive cooling treatment but is not subjected to control by photoperiod in P. aphrodite. Phloem or shoot apex-specific expression of PaFT1 restores the late flowering of Arabidopsis ft mutants. Moreover, PaFT1 can suppress the delayed flowering caused by SHORT VEGATATIVE PHASE (SVP) overexpression as well as an active FRIGIDA (FRI) allele, indicating the functional conservation of flowering regulatory circuit in different plant species. PaFT1 promoter:GUS in Arabidopsis showed similar staining pattern to that of Arabidopsis FT in the leaves and guard cells but different in the shoot apex. A genomic clone or heat shock-inducible expression of PaFT1 is sufficient to the partial complementation of the ft mutants. Remarkably, ectopic PaFT1 expression also triggers precocious heading in rice. To further demonstrate the functional conservation of the flowering regulators, we show that PaFD, a bZIP transcription factor involved in flowering promotion, interacts with PaFT1, and PaFD partially complemented Arabidopsis fd mutants. Transgenic rice expressing PaFD also flowered early with increased expression of rice homologues of APETALA1 (AP1). Consistently, PaFT1 knock-down Phalaenopsis plants generated by virus-induced gene silencing exhibit delayed spiking. These studies suggest functional conservation of FT and FD genes, which may have evolved and integrated into distinct regulatory circuits in monopodial orchids, Arabidopsis and rice that promote flowering under their own inductive conditions. PMID:26317412

  19. 231Pa and 233Pa Neutron-Induced Fission Data Analysis

    SciTech Connect

    Maslov, V.M.; Tetereva, N.A.; Baba, M.; Hasegawa, A.; Kornilov, N.V.; Kagalenko, A.B.

    2005-05-24

    The 231Pa and 233Pa neutron-induced fission cross-section database is analyzed within the Hauser-Feshbach approach. The consistency of neutron-induced fission cross-section data and data extracted from transfer reactions is investigated. The fission probabilities of Pa, fissioning in 231,233Pa(n,nf) reactions, are defined by fitting (3He,d) or (3He,t) transfer-reaction data. The present estimate of the 233Pa(n,f) fission cross section above the emissive fission threshold is supported by smooth level-density parameter systematics, validated in the case of the 231Pa(n,f) data description up to En =20 MeV.

  20. 76 FR 58327 - Pennsylvania Disaster #PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... ADMINISTRATION Pennsylvania Disaster PA-00044 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the Commonwealth of... 76155. FOR FURTHER INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small...

  1. 76 FR 64419 - Pennsylvania Disaster #PA-00045

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... ADMINISTRATION Pennsylvania Disaster PA-00045 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the... Kingsport Road, Fort Worth, TX 76155. FOR FURTHER INFORMATION CONTACT: A. Escobar, Office of...

  2. 76 FR 58328 - Pennsylvania Disaster #PA-00042

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... ADMINISTRATION Pennsylvania Disaster PA-00042 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the Commonwealth of..., Fort Worth, TX 76155. FOR FURTHER INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance,...

  3. 77 FR 60004 - Pennsylvania Disaster #PA-00053

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00053 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  4. 32 CFR 701.113 - PA exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.113 PA exemptions. (a) Exempt systems of records. 5 U.S.C. 552a authorizes SECNAV to adopt rules designating eligible systems of records as exempt from... responsible for proposing an exemption rule. Exempt systems of records are identified at...

  5. 78 FR 60366 - Pennsylvania Disaster #PA-00064

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00064 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... Application Deadline Date: 06/24/2014. ADDRESSES: Submit completed loan applications to: U.S. Small...

  6. Seepage Model for PA Including Dift Collapse

    SciTech Connect

    G. Li; C. Tsang

    2000-12-20

    The purpose of this Analysis/Model Report (AMR) is to document the predictions and analysis performed using the Seepage Model for Performance Assessment (PA) and the Disturbed Drift Seepage Submodel for both the Topopah Spring middle nonlithophysal and lower lithophysal lithostratigraphic units at Yucca Mountain. These results will be used by PA to develop the probability distribution of water seepage into waste-emplacement drifts at Yucca Mountain, Nevada, as part of the evaluation of the long term performance of the potential repository. This AMR is in accordance with the ''Technical Work Plan for Unsaturated Zone (UZ) Flow and Transport Process Model Report'' (CRWMS M&O 2000 [153447]). This purpose is accomplished by performing numerical simulations with stochastic representations of hydrological properties, using the Seepage Model for PA, and evaluating the effects of an alternative drift geometry representing a partially collapsed drift using the Disturbed Drift Seepage Submodel. Seepage of water into waste-emplacement drifts is considered one of the principal factors having the greatest impact of long-term safety of the repository system (CRWMS M&O 2000 [153225], Table 4-1). This AMR supports the analysis and simulation that are used by PA to develop the probability distribution of water seepage into drift, and is therefore a model of primary (Level 1) importance (AP-3.15Q, ''Managing Technical Product Inputs''). The intended purpose of the Seepage Model for PA is to support: (1) PA; (2) Abstraction of Drift-Scale Seepage; and (3) Unsaturated Zone (UZ) Flow and Transport Process Model Report (PMR). Seepage into drifts is evaluated by applying numerical models with stochastic representations of hydrological properties and performing flow simulations with multiple realizations of the permeability field around the drift. The Seepage Model for PA uses the distribution of permeabilities derived from air injection testing in niches and in the cross drift to

  7. Russian Teaching Contracts.

    ERIC Educational Resources Information Center

    Stevens, Betsy

    2000-01-01

    Analyzes two Russian teaching contracts, rhetorically comparing purpose and audience, culture, gender, and the role of the individual versus the state. Uses anecdotal episodes as a framework for examining Russian culture and analyzing university teaching contracts, concluding that the contracts are not only brief and factual but also reflect a…

  8. Teaching about Contracts.

    ERIC Educational Resources Information Center

    Froman, Michael; Kosnoff, Kathy

    1978-01-01

    Presents teaching strategies for introducing high school students to contract law. Offers as a case study a contract agreement between pro football players and team owners. Stresses basic elements of contracts (offer, acceptance, consideration, and understanding the bargaining process). Journal available from the American Bar Association, 1155…

  9. The Joy of Contracts.

    ERIC Educational Resources Information Center

    Hegarty, Kevin

    This paper is a practical guide that explains and illustrates contracts between libraries and vendors for computerized circulation systems. It describes the elements of a typical contract to include the equipment and services that should be specified in the contract and establishes scheduling and acceptance testing needs. Included in a contract…

  10. Technical Insights for Saltstone PA Maintenance

    SciTech Connect

    Flach, G.; Sarkar, S.; Mahadevan, S.; Kosson, D.

    2011-07-20

    The Cementitious Barriers Partnership (CBP) is a collaborative program sponsored by the US DOE Office of Waste Processing. The objective of the CBP is to develop a set of computational tools to improve understanding and prediction of the long-term structural, hydraulic, and chemical performance of cementitious barriers and waste forms used in nuclear applications. CBP tools are expected to better characterize and reduce the uncertainties of current methodologies for assessing cementitious barrier performance and increase the consistency and transparency of the assessment process, as the five-year program progresses. In September 2009, entering its second year of funded effort, the CBP sought opportunities to provide near-term tangible support to DOE Performance Assessments (PAs). The Savannah River Saltstone Disposal Facility (SDF) was selected for the initial PA support effort because (1) cementitious waste forms and barriers play a prominent role in the performance of the facility, (2) certain important long-term behaviors of cementitious materials composing the facility are uncertain, (3) review of the SDF PA by external stakeholders is ongoing, and (4) the DOE contractor responsible for the SDF PA is open to receiving technical assistance from the CBP. A review of the current (SRR Closure & Waste Disposal Authority 2009) and prior Saltstone PAs (e.g., Cook et al. 2005) suggested five potential opportunities for improving predictions. The candidate topics considered were (1) concrete degradation from external sulfate attack, (2) impact of atmospheric exposure to concrete and grout before closure, such as accelerated slag and Tc-99 oxidation, (3) mechanistic prediction of geochemical conditions, (4) concrete degradation from rebar corrosion due to carbonation, and (5) early age cracking from drying and/or thermal shrinkage. The candidate topics were down-selected considering the feasibility of addressing each issue within approximately six months, and

  11. {sup 231}Pa photofission cross section

    SciTech Connect

    Soldatov, A.S.; Rudnikov, V.E.; Smirenkin, G.N.

    1995-12-01

    The measurements of the {sup 231}Pa yield and cross section photofission in the energy range 7-9 MeV are presented. These measurements are a continuation of similar measurements performed for the {gamma}-ray energy range 4.8-7 MeV. The entire collection of experimental data which combine the results obtained in the present work and in Ref. 1 was analyzed.

  12. Graphs for Isotopes of 91-Pa (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides a graphic representation of nucleon separation energies and residual interaction parameters for isotopes of the chemical element 91-Pa (Protactinium, atomic number Z = 91).

  13. Indoor radon levels in Cumberland County, PA

    SciTech Connect

    Cohen, B.L.; Nason, R.

    1987-01-01

    Measurements were made of radon levels in 165 randomly selected homes in Cumberland County, PA during Winter 1984-1985. The average and mean levels were found to be 9.1 +/- 0.7 pCi/L and 6.3 +/- 0.5 pCi/L, respectively, many times normally encountered levels. Average and mean radon levels are reported vs. various house characteristics. 4 references, 1 figure, 6 tables.

  14. Sensor Kinase PA4398 Modulates Swarming Motility and Biofilm Formation in Pseudomonas aeruginosa PA14

    PubMed Central

    Strehmel, Janine; Neidig, Anke; Nusser, Michael; Geffers, Robert; Brenner-Weiss, Gerald

    2014-01-01

    Pseudomonas aeruginosa is an opportunistic human pathogen that is able to sense and adapt to numerous environmental stimuli by the use of transcriptional regulators, including two-component regulatory systems. In this study, we demonstrate that the sensor kinase PA4398 is involved in the regulation of swarming motility and biofilm formation in P. aeruginosa PA14. A PA4398− mutant strain was considerably impaired in swarming motility, while biofilm formation was increased by approximately 2-fold. The PA4398− mutant showed no changes in growth rate, rhamnolipid synthesis, or the production of the Pel exopolysaccharide but exhibited levels of the intracellular second messenger cyclic dimeric GMP (c-di-GMP) 50% higher than those in wild-type cells. The role of PA4398 in gene regulation was investigated by comparing the PA4398− mutant to the wild-type strain by using microarray analysis, which demonstrated that 64 genes were up- or downregulated more than 1.5-fold (P < 0.05) under swarming conditions. In addition, more-sensitive real-time PCR studies were performed on genes known to be involved in c-di-GMP metabolism. Among the dysregulated genes were several involved in the synthesis and degradation of c-di-GMP or in the biosynthesis, transport, or function of the iron-scavenging siderophores pyoverdine and pyochelin, in agreement with the swarming phenotype observed. By analyzing additional mutants of selected pyoverdine- and pyochelin-related genes, we were able to show that not only pvdQ but also pvdR, fptA, pchA, pchD, and pchH are essential for the normal swarming behavior of P. aeruginosa PA14 and may also contribute to the swarming-deficient phenotype of the PA4398− mutant in addition to elevated c-di-GMP levels. PMID:25501476

  15. Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility

    PubMed Central

    Huang, Lin; Haratake, Kousuke; Miyahara, Hatsumi; Chiba, Tomoki

    2016-01-01

    Protein degradation mediated by the proteasome is important for the protein homeostasis. Various proteasome activators, such as PA28 and PA200, regulate the proteasome function. Here we show double knockout (dKO) mice of Psme3 and Psme4 (genes for PA28γ and PA200), but not each single knockout mice, are completely infertile in male. The dKO sperms exhibited remarkable defects in motility, although most of them showed normal appearance in morphology. The proteasome activity of the mutant sperms decreased notably, and the sperms were strongly positive with ubiquitin staining. Quantitative analyses of proteins expressed in dKO sperms revealed up-regulation of several proteins involved in oxidative stress response. Furthermore, increased 8-OHdG staining was observed in dKO sperms head, suggesting defective response to oxidative damage. This report verified PA28γ and PA200 play indispensable roles in male fertility, and provides a novel insight into the role of proteasome activators in antioxidant response. PMID:27003159

  16. Contracting guidelines for internists.

    PubMed

    1984-09-01

    Government regulations, the introduction of new health care delivery methods, and the rising number of physicians joining the medical community have combined to increase the importance of the business aspect of medical practice. As a result, many physicians have documented their relationships with various third parties through contracts. As the incidence of contractual relationships between physicians and third parties has increased, so has concern regarding the legal ramifications of the contracting process. This guide is intended to explain the basic characteristics of contracts and to provide the individual physician with information regarding the contracting process. The guide is divided into three sections: key elements of a contract; types of contracts, including hospital/physician contracts, hospital/physician joint ventures, and group practice contracts; and negotiating the contract. Each section offers an explanation of the topic, which is followed by specific questions for the individual physician to investigate. These lists of questions are designed to provide a starting point for physician discussion of the philosophical, personal and practical areas to investigate before entering into a contract. PMID:10268633

  17. Sensor kinase PA4398 modulates swarming motility and biofilm formation in Pseudomonas aeruginosa PA14.

    PubMed

    Strehmel, Janine; Neidig, Anke; Nusser, Michael; Geffers, Robert; Brenner-Weiss, Gerald; Overhage, Joerg

    2015-02-01

    Pseudomonas aeruginosa is an opportunistic human pathogen that is able to sense and adapt to numerous environmental stimuli by the use of transcriptional regulators, including two-component regulatory systems. In this study, we demonstrate that the sensor kinase PA4398 is involved in the regulation of swarming motility and biofilm formation in P. aeruginosa PA14. APA4398 mutant strain was considerably impaired in swarming motility, while biofilm formation was increased by approximately 2-fold. The PA4398 mutant showed no changes in growth rate, rhamnolipid synthesis, or the production of the Pel exopolysaccharide but exhibited levels of the intracellular second messenger cyclic dimeric GMP (c-di-GMP) 50% higher than those in wild-type cells. The role of PA4398 in gene regulation was investigated by comparing the PA4398 mutant to the wildtype strain by using microarray analysis, which demonstrated that 64 genes were up- or downregulated more than 1.5-fold (P<0.05) under swarming conditions. In addition, more-sensitive real-time PCR studies were performed on genes known to be involved in c-di-GMP metabolism. Among the dysregulated genes were several involved in the synthesis and degradation of c-di-GMP or in the biosynthesis, transport, or function of the iron-scavenging siderophores pyoverdine and pyochelin, in agreement with the swarming phenotype observed. By analyzing additional mutants of selected pyoverdine- and pyochelin-related genes,we were able to show that not only pvdQ but also pvdR, fptA, pchA, pchD, and pchH are essential for the normal swarming behavior of P. aeruginosa PA14 and may also contribute to the swarming-deficient phenotype of the PA4398 mutant in addition to elevated c-di-GMP levels. PMID:25501476

  18. 42. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    42. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant No. 7, Office Entrances, Wissahickon Avenue. The Ballinger Company - Atwater Kent Manufacturing Company, North Plant, 5000 Wissahickon Avenue, Philadelphia, Philadelphia County, PA

  19. 41. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant No. 7, Elevation and Plan of Bridge. The Ballinger Company (1928) - Atwater Kent Manufacturing Company, North Plant, 5000 Wissahickon Avenue, Philadelphia, Philadelphia County, PA

  20. 38. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. Drawing entitled Atwater Kent Mfg. Co., Philadelphia, Pa., Plant No. 7, First Story. The Ballinger Company (1928) - Atwater Kent Manufacturing Company, North Plant, 5000 Wissahickon Avenue, Philadelphia, Philadelphia County, PA

  1. 7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  2. 5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.58. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  3. 4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.73 - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  4. 6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  5. 20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.25. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  6. 48 CFR 235.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contracting methods and contract type. 235.006 Section 235.006 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.006 Contracting methods and...

  7. 48 CFR 235.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contracting methods and contract type. 235.006 Section 235.006 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.006 Contracting methods and...

  8. Contract Training for Industry.

    ERIC Educational Resources Information Center

    Averill, Donald F.

    1983-01-01

    Describes contract training whereby industries arrange with community colleges, technical institutes, and vocational schools to prepare employees for specific job assignments. Indicates that industrial training performed under contract with public institutions should be encouraged in favor of expansion of training that industry performs for…

  9. Performance Contracting Overview.

    ERIC Educational Resources Information Center

    Wohlferd, Gerald H.

    Conclusions reached after three years of performance contracting experience and materials with which to judge the validity of the conclusions are presented in this overview of performance contracting. The conclusions are: (1) commercial firms are no better at teaching children than are public schools; (2) commercial firms expend as much or more…

  10. Contract Teachers in India

    ERIC Educational Resources Information Center

    Goyal, Sangeeta; Pandey, Priyanka

    2013-01-01

    In this paper, we use non-experimental data from government schools in Uttar Pradesh and Madhya Pradesh, two of the largest Indian states, to present average school outcomes by contract status of teachers. We find that contract teachers are associated with higher effort than civil service teachers with permanent tenures, before as well as after…

  11. Working Papers on Contract Education.

    ERIC Educational Resources Information Center

    Mullen, Robert; And Others

    Included in this package are: a copy of a learning contract between two students; an abstract fulfilling part of the contract objectives; and six papers on the topic of contract education. The goal of the learning contract was to edit and prepare for publication "Working Papers on Contract Education". The credential awarded for satisfactory…

  12. PaDe - The particle detection program

    NASA Astrophysics Data System (ADS)

    Ott, T.; Drolshagen, E.; Koschny, D.; Poppe, B.

    2016-01-01

    This paper introduces the Particle Detection program PaDe. Its aim is to analyze dust particles in the coma of the Jupiter-family comet 67P/Churyumov-Gerasimenko which were recorded by the two OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) cameras onboard the ESA spacecraft Rosetta, see e.g. Keller et al. (2007). In addition to working with the Rosetta data, the code was modified to work with images from meteors. It was tested with data recorded by the ICCs (Intensified CCD Cameras) of the CILBO-System (Canary Island Long-Baseline Observatory) on the Canary Islands; compare Koschny et al. (2013). This paper presents a new method for the position determination of the observed meteors. The PaDe program was written in Python 3.4. Its original intent is to find the trails of dust particles in space from the OSIRIS images. For that it determines the positions where the trail starts and ends. They were found using a fit following the so-called error function (Andrews, 1998) for the two edges of the profiles. The positions where the intensities fall to the half maximum were found to be the beginning and end of the particle. In the case of meteors, this method can be applied to find the leading edge of the meteor. The proposed method has the potential to increase the accuracy of the position determination of meteors dramatically. Other than the standard method of finding the photometric center, our method is not influenced by any trails or wakes behind the meteor. This paper presents first results of this ongoing work.

  13. 48 CFR 35.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.006 Contracting methods and... projects when the objectives of the research are well defined and there is sufficient confidence in...

  14. Parrot Bornavirus (PaBV)-2 isolate causes different disease patterns in cockatiels than PaBV-4.

    PubMed

    Piepenbring, Anne K; Enderlein, Dirk; Herzog, Sibylle; Al-Ibadi, Basim; Heffels-Redmann, Ursula; Heckmann, Julia; Lange-Herbst, Hildburg; Herden, Christiane; Lierz, Michael

    2016-01-01

    Psittaciform 1 bornavirus (PaBV) has already been shown to be the aetiologic agent of proventricular dilatation disease, a significant disease of birds. However, the pathogenesis of PaBV infection has not yet been resolved and valid data regarding the pathogenicity of different PaBV species are lacking. Thus, the present study was aimed to characterize the influence of two different PaBV species on the course of disease. Eighteen cockatiels were inoculated intracerebrally (i.c.) or intravenously (i.v.) with a PaBV-2 isolate under the same conditions as in a previous study using PaBV-4. Birds were surveyed and sampled for 33 weeks to analyse the course of infection and disease in comparison to that of PaBV-4. Similar to PaBV-4, PaBV-2 induced a persistent infection with seroconversion (from day 6 p.i. onwards) and shedding of viral RNA (from day 27 p.i. onwards). However, in contrast to PaBV-4, more birds displayed clinical signs and disease progression was more severe. After PaBV-2 infection, 12 birds exhibited clinical signs and 10 birds revealed a dilated proventriculus in necropsy. After PaBV-4 infection only four birds revealed clinical signs and seven birds showed a dilatation of the proventriculus. Clinically, different courses of disease were observed after PaBV-2 infection, mainly affecting the gastrointestinal tract. This had not been detected after PaBV-4 infection where more neurological signs were noted. The results provide evidence for different disease patterns according to different PaBV species, allowing the comparison between the infection with two PaBV species, and thus underlining the role of viral and individual host factors for disease outcome. PMID:27100150

  15. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Freedom of Information (FOIA), or PA/FOIA. 701.120 Section 701.120 National Defense Department of Defense... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA. Individuals do not always know what Act(s) to cite when requesting information. Nonetheless,...

  16. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Freedom of Information (FOIA), or PA/FOIA. 701.120 Section 701.120 National Defense Department of Defense... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA. Individuals do not always know what Act(s) to cite when requesting information. Nonetheless,...

  17. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Freedom of Information (FOIA), or PA/FOIA. 701.120 Section 701.120 National Defense Department of Defense... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA. Individuals do not always know what Act(s) to cite when requesting information. Nonetheless,...

  18. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Freedom of Information (FOIA), or PA/FOIA. 701.120 Section 701.120 National Defense Department of Defense... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA. Individuals do not always know what Act(s) to cite when requesting information. Nonetheless,...

  19. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Freedom of Information (FOIA), or PA/FOIA. 701.120 Section 701.120 National Defense Department of Defense... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA. Individuals do not always know what Act(s) to cite when requesting information. Nonetheless,...

  20. The Case for Performance Contracting.

    ERIC Educational Resources Information Center

    Miller, Sutherland; Wilson, Nancy

    1981-01-01

    Discussed the State of Colorado's introduction of performance contracting into its relationships with community mental health centers. Describes the nature of the contract and its implementation. Particular emphasis is placed on the implications of the contract for program evaluation. (Author)

  1. Mechanics of Vorticella contraction.

    PubMed

    Misra, Gaurav; Dickinson, Richard B; Ladd, Anthony J C

    2010-06-16

    Vorticella convallaria is one of a class of fast-moving organisms that can traverse its body size in less than a millisecond by rapidly coiling a slender stalk anchoring it to a nearby surface. The stalk houses a fiber called the spasmoneme, which winds helically within the stalk and rapidly contracts in response to calcium signaling. We have developed a coupled mechanical-chemical model of the coiling process, accounting for the coiling of the elastic stalk and the binding of calcium to the protein spasmin. Simulations of the model describe the contraction and recovery processes quantitatively. The stalk-spasmoneme system is shown to satisfy geometric constraints, which explains why the cell body sometimes rotates during contraction. The shape of the collapsing and recovering stalk bounds its effective bending stiffness. Simulations suggest that recovery from the contracted state is driven by the stalk at a rate controlled by dissociation of calcium from spasmin. PMID:20550905

  2. The Pseudomonas aeruginosa PA01 Gene Collection

    PubMed Central

    LaBaer, Joshua; Qiu, QingQing; Anumanthan, Anukanth; Mar, Wenhong; Zuo, Dongmei; Murthy, T.V.S.; Taycher, Helen; Halleck, Allison; Hainsworth, Eugenie; Lory, Stephen; Brizuela, Leonardo

    2004-01-01

    Pseudomonas aeruginosa, a common inhabitant of soil and water, is an opportunistic pathogen of growing clinical relevance. Its genome, one of the largest among bacteria [5570 open reading frames (ORFs)] approaches that of simple eukaryotes. We have constructed a comprehensive gene collection for this organism utilizing the annotated genome of P. aeruginosa PA01 and a highly automated and laboratory information management system (LIMS)-supported production line. All the individual ORFs have been successfully PCR-amplified and cloned into a recombination-based cloning system. We have isolated and archived four independent isolates of each individual ORF. Full sequence analysis of the first isolate for one-third of the ORFs in the collection has been completed. We used two sets of genes from this repository for high-throughput expression and purification of recombinant proteins in different systems. The purified proteins have been used to set up biochemical and immunological assays directed towards characterization of histidine kinases and identification of bacterial proteins involved in the immune response of cystic fibrosis patients. This gene repository provides a powerful tool for proteome- and genome-scale research of this organism, and the strategies adopted to generate this repository serve as a model for building clone sets for other bacteria. PMID:15489342

  3. 48 CFR 35.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-reimbursement contracts is usually appropriate (see subpart 16.3). The nature of development work often requires... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.006 Contracting methods and..., performance objectives, and specifications for the work can be defined will largely determine the type...

  4. 48 CFR 35.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-reimbursement contracts is usually appropriate (see subpart 16.3). The nature of development work often requires... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.006 Contracting methods and..., performance objectives, and specifications for the work can be defined will largely determine the type...

  5. 48 CFR 35.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-reimbursement contracts is usually appropriate (see subpart 16.3). The nature of development work often requires... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.006 Contracting methods and..., performance objectives, and specifications for the work can be defined will largely determine the type...

  6. 48 CFR 235.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... development contract or a fixed-price type contract for the lead ship of a class, when the value of the work... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT... production option on a development contract for a major weapon system reasonably in advance of the...

  7. 48 CFR 235.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... development contract or a fixed-price type contract for the lead ship of a class, when the value of the work... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT... production option on a development contract for a major weapon system reasonably in advance of the...

  8. Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle.

    PubMed Central

    Masuda, Y; Yamahara, N S; Tanaka, M; Ryang, S; Kawai, T; Imaizumi, Y; Watanabe, M

    1995-01-01

    1. The characteristics of muscarinic receptors mediating relaxation and/or contraction in the rat iris dilator muscle were examined. 2. Relaxation was induced in a dilator muscle by application of acetylcholine (ACh) at low doses (3 microM or less) and contraction was induced by high doses. Methacholine and carbachol also showed biphasic effects similar to those of ACh; in contrast, bethanechol, arecoline, pilocarpine and McN-A-343 induced mainly relaxation but no substantial contraction. 3. After parasympathetic denervation by ciliary ganglionectomy, the relaxant response to muscarinic agonists disappeared upon nerve stimulation. Application of McN-A-343 and pilocarpine induced only small contractions in denervated dilator muscles, indicating that these are partial agonists for contraction. 4. pA2 values of pirenzepine, methoctramine, AF-DX 116, himbacine, and 4-DAMP for antagonism to pilocarpine-induced relaxation in normal dilator muscles and those for antagonism to ACh-induced contraction in denervated dilator muscles were determined. The pA2 values for antagonism to relaxation of all these antagonists were most similar to those for M3-type muscarinic receptors. 5. Although pA2 values for contraction of these antagonists, except for methoctramine, were very close to those for relaxation, contraction was not significantly antagonized by methoctramine. Contraction might be mediated by M3-like receptors which have a very low affinity for methoctramine. 6. In conclusion, ACh-induced biphasic responses in rat iris dilator muscles were clearly distinguished from each other by specific muscarinic agonists and parasympathetic denervation, whereas muscarinic receptors could not be subclassified according to the pA2 values of 5 specific antagonists only. PMID:7539696

  9. Affine Contractions on the Plane

    ERIC Educational Resources Information Center

    Celik, D.; Ozdemir, Y.; Ureyen, M.

    2007-01-01

    Contractions play a considerable role in the theory of fractals. However, it is not easy to find contractions which are not similitudes. In this study, it is shown by counter examples that an affine transformation of the plane carrying a given triangle onto another triangle may not be a contraction even if it contracts edges, heights or medians.…

  10. Nested and Dynamic Contract Boundaries

    NASA Astrophysics Data System (ADS)

    Strickland, T. Stephen; Felleisen, Matthias

    Previous work on software contracts assumes fixed and statically known boundaries between the parties to a contract. Implementations of contract monitoring systems rely on this assumption to explain the nature of contract violations and to assign blame to violators. In this paper, we explain how to implement arbitrary, nested, and dynamic contract boundaries with two examples. First, we add nestable contract regions to a static, first-order module system. Second, we show that even a dynamic, higher-order, and hierarchical module system can be equipped with software contracts that support precise blame assignment.

  11. Impact of Telephone Reinforcement and Negotiated Contracts on Behavioral Predictors of Exercise Maintenance in Older Adults with Osteoarthritis

    PubMed Central

    Desai, Pankaja M.; Hughes, Susan L.; Peters, Karen E.; Mermelstein, Robin J.

    2014-01-01

    Objectives To examine the impact of telephone reinforcement (TR) on predictors of physical activity (PA) maintenance in older adults with osteoarthritis. Methods Mixed effects modeling was conducted of data from a randomized PA trial that used negotiated maintenance contracts, supplemented by TR, to test impact of TR on barriers, decisional balance, and stage of change at multiple points in time. Results Participants who were referred to a PA program and received TR improved the most in barriers and decisional balance. Participants who negotiated a tailored maintenance contract but did not receive TR improved the most in stage. Conclusions TR appears to positively affect perceptions around engagement, whereas negotiation positively impacts PA behavior. Further research should examine the effectiveness of specific PA maintenance strategies. PMID:25181766

  12. Verapamil as an apparent competitive antagonist of the serotonin receptor of rabbit isolated aorta.

    PubMed

    Auguet, M; Delaflotte, S; Clostre, F; DeFeudis, F V

    1986-01-01

    The actions of four Ca2+-antagonists (verapamil, diltiazem, nifedipine and flunarizine) were tested on serotonin- (5-HT-) induced contraction of rabbit isolated aorta. Verapamil produced a dose-dependent, parallel shift to the right of the concentration-response curve for 5-HT (pA2 approximately equal to 7.13; Schild slope approximately equal to 1.01), indicative of competitive antagonism. The effects of diltiazem, nifedipine and flunarizine were much less pronounced and best characterized as non-competitive interactions. The effect of verapamil, which likely involves its antagonism of smooth muscle 5-HT2-receptors, might be useful in explaining its therapeutic actions and/or its side-effects. PMID:3699438

  13. Kingsfield Doesn't Teach My Contracts Class: Using Contracts To Teach Contracts.

    ERIC Educational Resources Information Center

    Warkentine, Edith R.

    2000-01-01

    A law school professor describes her approach to teaching Contracts through the analysis of actual contracts instead of through case briefings. Considered are educational objectives of the Contracts course; the five discrete methods commonly used to teach Contracts; why the author's approach is more successful in integrating theory doctrine, and…

  14. Consensus, contracts, and committees.

    PubMed

    Moreno, J D

    1991-08-01

    Following a brief account of the puzzle that ethics committees present for the Western Philosophical tradition, I will examine the possibility that social contract theory can contribute to a philosophical account of these committees. Passing through classical as well as contemporary theories, particularly Rawls' recent constructivist approach, I will argue that social contract theory places severe constraints on the authority that may legitimately be granted to ethics committees. This, I conclude, speaks more about the suitability of the theory to this level of analysis than about the ethics committee phenomenon itself. PMID:1895024

  15. 48 CFR 3017.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Contracts. 3017.204... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3017.204 Contracts....

  16. 48 CFR 3017.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contracts. 3017.204 Section... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3017.204 Contracts....

  17. 48 CFR 3017.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Contracts. 3017.204... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3017.204 Contracts....

  18. 48 CFR 3017.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Contracts. 3017.204... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options. 3017.204 Contracts....

  19. 48 CFR 16.307 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... commercial item) is contemplated. If the contract is with an educational institution, modify the clause by... AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.307 Contract clauses. (a)(1)...

  20. 48 CFR 3017.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contracts. 3017.204... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options. 3017.204 Contracts....

  1. Genome Sequence of Pseudomonas chlororaphis Strain PA23

    PubMed Central

    Loewen, Peter C.; Villenueva, Jacylyn; Fernando, W. G. Dilantha

    2014-01-01

    Pseudomonas chlororaphis strain PA23 is a plant-beneficial bacterium that is able to suppress disease caused by the fungal pathogen Sclerotinia sclerotiorum through a process known as biological control. Here we present a 7.1-Mb assembly of the PA23 genome. PMID:25035328

  2. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  3. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  4. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  5. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  6. Atomic structure of anthrax PA pore elucidates toxin translocation

    PubMed Central

    Jiang, Jiansen; Pentelute, Bradley L.; Collier, R. John; Zhou, Z. Hong

    2015-01-01

    Summary Anthrax toxin, comprising protective antigen (PA), lethal factor (LF) and edema factor (EF), is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in human and animals. PA forms oligomeric prepores that undergo conversion to membrane-spanning pores by endosomal acidification, and these pores translocate the enzymes LF and EF into the cytosol of target cells1. PA is not only a vaccine component and therapeutic target for anthrax infections but also an excellent model system for understanding the mechanism of protein translocation. Based on biochemical and electrophysiological results, researchers have proposed that a Φ-clamp composed of Phe427 residues of PA catalyzes protein translocation via a charge-state dependent Brownian ratchet2–9. Although atomic structures of PA prepores are available10–14, how PA senses low pH, converts to active pore and translocates LF and EF are not well defined without an atomic model of the PA pore. Here, by cryo electron microscopy (cryoEM) with direct electron counting, we have determined the PA pore structure at 2.9-Å resolution. The structure reveals the long-sought-after catalytic Φ-clamp and the membrane-spanning translocation channel, and supports the Brownian ratchet model for protein translocation. Comparisons of four structures reveal conformational changes in prepore to pore conversion that support a multi-step mechanism by which low-pH is sensed and the membrane-spanning channel is formed. PMID:25778700

  7. Bed plate for rail bending machine, Johnson Company, Johnstown, Pa. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bed plate for rail bending machine, Johnson Company, Johnstown, Pa. Scale 3 inches - 1 ft, Jan 30th 1893, drawing number 14929. (Photograph of drawing held at the Johnstown Corporation General Office,Johnstown, Pennsylvania) - Johnson Steel Street Rail Company, 525 Central Avenue, Johnstown, Cambria County, PA

  8. General plan, bending machinge, Johnson Company, Johnstown, Pa. Scale 3 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General plan, bending machinge, Johnson Company, Johnstown, Pa. Scale 3 inches - 1 ft, March 13th 1893, drawing number 15384 (photograph of drawing of rail bending machine held at the Johnstown Corporation General Office, Johnstown, Pennsylvania) - Johnson Steel Street Rail Company, 525 Central Avenue, Johnstown, Cambria County, PA

  9. 78 FR 26243 - Amendment of Class E Airspace; Easton, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... Federal Register a notice of proposed rulemaking (NPRM) to amend Class E airspace at Easton, PA (78 FR..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Easton, PA AGENCY:...

  10. 77 FR 45240 - Establishment of Class E Airspace; Quakertown, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... Airspace at Quakertown, PA, to accommodate the new Area Navigation (RNAV) Global Positioning System (GPS... Quakertown, PA (77 FR 30438) Docket No. FAA-2012-0386. Interested parties were invited to participate in this... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory...

  11. 77 FR 16669 - Establishment of Class E Airspace; Bellefonte, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... airspace at Bellefonte, PA, to accommodate new Area Navigation (RNAV) Global Positioning System (GPS... surface at Bellefonte, PA (76 FR 79564). Interested parties were invited to participate in this rulemaking... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) ] does not warrant preparation of...

  12. 76 FR 64234 - Establishment of Class E Airspace; Palmyra, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... airspace at Palmyra, PA, to accommodate new Area Navigation (RNAV) Global Positioning System (GPS) Standard... (NPRM) to amend Class E airspace 700 feet above the surface, at Palmyra, PA (76 FR 49390). Interested... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory...

  13. Observations of 231Pa/ 235U disequilibrium in volcanic rocks

    NASA Astrophysics Data System (ADS)

    Pickett, David A.; Murrell, Michael T.

    1997-04-01

    We present here the first survey of ( 231Pa/ 235U) ratios in volcanic rocks; such measurements are made possible by new mass spectrometric techniques. The data place new constraints on the timing and extent of magma source and evolutionary processes, particularly due to the sensitivity of the 231Pa- 235U pair and its intermediate time scale ( 231Pat 1/2 = 33 ky). ( 231Pa/ 235U) is found to vary widely, from 0.2 in carbonatites to 1.1-2.9 in basalts and 0.9-2.2 in arcs. Substantial Pa enrichment is nearly ubiquitous, suggestive of the relative incompatibility of Pa, qualitatively consistent with available partitioning data. The level of 231Pa- 235U disequilibrium typically far exceeds that of 230Th- 238U and is comparable to 226Ra- 230Th. The high ( 231Pa/ 235U) ratios in MORB and other basalts reflect a large degree of discrimination between two incompatible elements, posing challenges for modelling of melt generation and migration. Fundamental differences in ( 231Pa/ 235U) among different basaltic environments are likely related to contrasts in melting zone conditions (e.g., melting rate). Strong ( 231Pa/ 235U) disequilibria in continental basalts, for which ( 230Th/ 238U) disequilibria are small or absent, demonstrate that Pa-U fractionation is possible in both garnet and spinel mantle stability fields. In arcs, correlation of ( 231Pa/ 235U) and ( 230Th/ 238U) is consistent with U enrichment via slab-derived fluids, a process which is additional to the still dominant Pa enrichment. An important new constraint is provided by the observation that the near-equilibrium ( 230Th/ 238U) common to arcs and continental basalts is not typically accompanied by near-equilibrium ( 231Pa/ 235U), arguing against the influence of long magma history, crustal material, or equilibrium mantle sources in affecting decay-series ratios. Small sample sets from two silicic centers illustrate: (1) recent, rapid U enrichment in the magma chamber (El Chichón); and (2) the failure of

  14. Acting Out Muscle Contraction.

    ERIC Educational Resources Information Center

    Hudson, Margaret

    2003-01-01

    Describes a science activity that can be implemented into anatomy and physiology courses that demonstrates the interactions between action and myosin, the roles of sodium and calcium ions in the regulation of contraction, and the functions of the plasma membrane and the sarcoplasmic reticulum. (YDS)

  15. Contracting for Audit Services.

    ERIC Educational Resources Information Center

    Heifetz, Harry S.

    1987-01-01

    The Single Audit Act of 1984 requires most school districts receiving over $25,000 in federal funds to undergo financial audits. This article highlights requirements for selecting certified public accountants to perform the audit and suggests factors to be considered before drafting a contract or letter of engagement. A sample letter is included.…

  16. Contracting with Teacher Partnerships.

    ERIC Educational Resources Information Center

    Shaten, Jessica; Kolderie, Ted

    This monograph describes the concept of school district contracts with teacher partnerships for educational services; taking the view of education as an industry, the document analyzes advantages, obstacles, and strategies of such a change. Section 1, "The Challenge," suggests that societal changes make an education industry outside the K-12…

  17. Copyright or Contract?

    ERIC Educational Resources Information Center

    Okerson, Ann

    1997-01-01

    Most authors and publishers of electronic information believe that current copyright law does not address technical capabilities or reader uses and have turned to contracts or licenses to define the rights of owners and users. Discusses copyrights, fair use, and licenses and highlights licensing's unresolved issues: use and users; archiving;…

  18. Contracting for directorships.

    PubMed

    Knapp, Donna K

    2013-05-01

    Hospitals are required to have a medical director of respiratory care as a condition of their participation in the Federal Medicare and Medicaid programs. This gives physicians opportunities to improve the quality of care for the patients in their community, to diversify income streams, and to assist hospitals to meet regulatory requirements for quality. The contracts for these positions are usually provided by the hospital, so it is imperative that physicians know how to protect their interests, what is expected of them, if they are being paid fairly, and that the contract is compliant with all regulatory issues. The directorship relationship with the hospital that provides designated health services and the "stand in the shoes" definition of direct compensation also gives physicians and physician practices guidance to determine if their group and individual physicians are compliant with Stark and antikickback regulations. This article guides physicians through the process of reviewing a contract for medical directorship or service line management services. Information on compensation in the directorship market can be found in at least two standard surveys. Duties and compensation vary among entities and frequently include incentive-based compensation for improving quality measures and operations. Directorships are evolving to service line management as more of the hospital's reimbursement is linked to clinical quality and patient satisfaction. This article does not offer legal advice, nor is it meant to be all inclusive. Physicians should consult a health-care attorney for any questions before signing any contract. PMID:23648911

  19. Elucidating Protactinium Hydrolysis: The Relative Stabilities of PaO2(H2O)(+) and PaO(OH)2(+).

    PubMed

    Dau, Phuong D; Wilson, Richard E; Gibson, John K

    2015-08-01

    It is demonstrated that the gas-phase oxo-exchange of PaO2(+) with water is substantially faster than that of UO2(+), indicating that the Pa-O bonds are more susceptible to activation and formation of the bis-hydroxide intermediate, PaO(OH)2(+). To elucidate the nature of the water adduct of PaO2(+), hydration of PaO2(+) and UO2(+), as well as collision induced dissociation (CID) and ligand-exchange of the water adducts of PaO2(+) and UO2(+), was studied. The results indicate that, in contrast to UO2(H2O)(+), the protactinium oxo bis-hydroxide isomer, PaO(OH)2(+), is produced as a gas-phase species close in energy to the hydrate isomer, PaO2(H2O)(+). CID behavior similar to that of Th(OH)3(+) supports the assignment as PaO(OH)2(+). The gas-phase results are consistent with the spontaneous hydrolysis of PaO2(+) in aqueous solution, this in contrast to later AnO2(+) (An = U, Np, Pu), which forms stable hydrates in both solution and gas phase. In view of the known propensity for Th(IV) to hydrolyze, and previous gas-phase studies of other AnO2(+), it is concluded that the stabilities of oxo-hydroxides relative to oxide hydrates decreases in the order: Th(IV) > Pa(V) > U(V) > Np(V) > Pu(V). This trend suggests increasing covalency and decreasing ionicity of An-O bonds upon proceeding across the actinide series. PMID:26203499

  20. Employee contract issues for dermatologists.

    PubMed

    Brown, Christopher E; Indest, George F

    2013-12-01

    Employees and employers routinely face negotiating and preparing physician employment contracts. It is important for both sides to know and understand the basic information on what a comprehensive employment contract for a dermatologist should contain. There are various employment contract provisions from both the employee's perspective and the employer's perspective that must be considered when preparing physician employment contracts. This article provides basic advice and recommendations on requirements that should be included in such contracts. It suggests legal pitfalls that can be avoided through various contract clauses. PMID:24800433

  1. PA014-- Deception and Doubt --Strategies for Undermining and Supporting Global Climate Science--PA014

    NASA Astrophysics Data System (ADS)

    Nelson, C.

    2012-12-01

    DECEPTION AND DOUBT--STRATEGIES FOR UNDERMINING AND SUPPORTING GLOBAL CLIMATE SCIENCE--PA014 The fundamental strategy for undermining confidence in the now substantial scientific consensus about global warming is to sow doubt about the degree of consensus. Rather than mount an obvious anti-science stance, commercial interests seek to champion science, arguing for better science, more complete and definitive science. This strategy has a sixty-year history, beginning with the tobacco industry in the 1950s and proceeding through the chemical, energy, paint, and other industries. Thousands of faculty members have quietly sold themselves as public spokespersons or confidential consultants to industry in the service of this strategy. A multipart program--involving educating people about this history and exposing faculty collaboration--may help free climate science from those who aim to distort its conclusions.

  2. Effects of cyclopiazonic acid and dexamethasone on serotonin-induced calcium responses in vascular smooth muscle cells.

    PubMed

    Selli, Cigdem; Tosun, Metiner

    2016-06-01

    We previously observed that sarcoendoplasmic reticulum Ca(2+) ATPase (SERCA) blockade by cyclopiazonic acid (CPA) significantly potentiates serotonin (5-hydroxytryptamine (5-HT))-induced vascular contractions. Furthermore, 5-HT receptor antagonist methysergide partially inhibited CPA-potentiated 5-HT contractions. In the present study, we further investigated whether SERCA inhibition potentiates 5-HT-induced Ca(2+) responses along with attenuating the receptor antagonism by store-operated Ca(2+) (SOC) entry and protein kinase C (PKC)-mediated mechanisms. The effects of dexamethasone that was previously shown to induce SOC entry and enhance 5-HT responses were also tested. For this purpose, intracellular Ca(2+) levels were monitored in A7r5 embryonic rat vascular smooth muscle cells by spectrofluorometry using the fluorescent indicator fura-2. The results showed that CPA, although not dexamethasone, significantly potentiated 5-HT-induced Ca(2+) elevations. Ketanserin partially decreased 5-HT-induced and CPA-potentiated Ca(2+) elevations whereas both PKC inhibitor D-sphingosine and SOC entry blocker 2-aminoethoxydiphenyl borate (2-APB) abolished the remaining responses. The data suggests that diminished antagonistic effect on 5-HT-induced Ca(2+) elevations in the presence of SERCA inhibition is induced by SOC entry and PKC activation. PMID:26944908

  3. 48 CFR 35.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., performance objectives, and specifications for the work can be defined will largely determine the type of contract employed. The contract type must be selected to fit the work required. (c) Because the absence of...-reimbursement contracts is usually appropriate (see subpart 16.3). The nature of development work often...

  4. 48 CFR 1335.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.006 Contracting methods and... is exempt from the requirements of 15 CFR part 27 and does not require Institutional Review Board... research involving human subjects to be carried out in performance of the award is exempt from 15 CFR...

  5. 48 CFR 1335.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.006 Contracting methods and... is exempt from the requirements of 15 CFR part 27 and does not require Institutional Review Board... research involving human subjects to be carried out in performance of the award is exempt from 15 CFR...

  6. Biogeography in 231Pa/230Th ratios and a balanced 231Pa budget for the Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Hayes, Christopher T.; Anderson, Robert F.; Fleisher, Martin Q.; Serno, Sascha; Winckler, Gisela; Gersonde, Rainer

    2014-04-01

    The ratio of unsupported protactinium-231 to thorium-230 in marine sediments, (Pa/Th)xs, is potentially sensitive to several processes of oceanographic and climatological interest: deep ocean circulation, marine biological productivity (as it relates to total particle flux) and particle composition (specifically, biogenic opal and authigenic Mn). In order to attribute variations in (Pa/Th)xs observed in sediment records to changes in specific processes through time, a better understanding of the chemical cycling of these elements in the modern ocean is necessary. To this end, a survey was undertaken of (Pa/Th)xs in surface sediments from the subarctic Pacific (SO202-INOPEX expedition) in combination with a Pacific-wide compilation of published data. Throughout the Pacific, (Pa/Th)xs is robustly correlated with the opal content of sediments. In the North and equatorial Pacific, simultaneous positive correlations with productivity indicators suggest that boundary scavenging and opal scavenging combine to enhance the removal of Pa in the eastern equatorial Pacific and subarctic Pacific. Deep ocean water mass ageing (>3.5 km) associated with the Pacific overturning appears to play a secondary role in determining the basin scale distribution of (Pa/Th)xs. A basin-wide extrapolation of Pa removal is performed which suggests that the Pacific Pa budget is nearly in balance. We hypothesize that through time (Pa/Th)xs distributions in the Pacific could define the evolving boundaries of contrasting biogeographic provinces in the North Pacific, while the influence of hydrothermal scavenging of Pa potentially confounds this approach in the South Pacific.

  7. Microfluidic manufacture of rt-PA-loaded echogenic liposomes

    PubMed Central

    Kandadai, Madhuvanthi A.; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J.; Papautsky, Ian; Holland, Christy K.

    2016-01-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (µtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the µtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The µtELIP had a mean diameter of 5 µm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5%bovine serum albumin. Additionally, 35 % of µtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes. PMID:27206512

  8. Microfluidic manufacture of rt-PA -loaded echogenic liposomes.

    PubMed

    Kandadai, Madhuvanthi A; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J; Papautsky, Ian; Holland, Christy K

    2016-06-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (μtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the μtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The μtELIP had a mean diameter of 5 μm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5 % bovine serum albumin. Additionally, 35 % of μtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes. PMID:27206512

  9. 48 CFR 3443.107 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clause. 3443.107... CONTRACT MANAGEMENT CONTRACT MODIFICATIONS General 3443.107 Contract clause. The contracting officer must... cost-reimbursement contracts in which it will be essential for the contracting officer to be...

  10. 48 CFR 16.302 - Cost contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost contracts. 16.302... AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.302 Cost contracts. (a) Description. A cost contract is a cost-reimbursement contract in which the contractor receives no fee....

  11. 48 CFR 937.7040 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CONTRACTING SERVICE CONTRACTING Protective Services Contracting 937.7040 Contract clauses. The contracting... services” in all protective services solicitations and contracts involving DOE-owned facilities requiring... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Contract clauses....

  12. Utility Energy Services Contracts Guide

    SciTech Connect

    2013-09-01

    The UESC Guide is a compilation of samples and templates developed as a resource to help contracting officers implement task orders for UESCs under existing U.S. General Services Administration areawide contracts.

  13. Contracts for dispatchable power

    SciTech Connect

    Kahn, E.P.; Stoft, S.; Marnay, C.; Berman, D.

    1990-10-01

    Competitive bidding for electric power is maturing. Increasing numbers of utilities are soliciting proposals from private suppliers. The amount of capacity being sought is increasing, and potential suppliers appear to be abundant. Analysis of these developments still remains limited. Evidence on the behavior of this market is scarce and sketchy. The underlying economic principles that are shaping the market have not clearly been articulated. In this report we examine the economics of competitive bidding both empirically and analytically. Previous study of this market has focused on the evaluation criteria specified in Requests for Proposals (RFPs), and highly aggregated summary statistics on participation and results. We continue the examination of RFPs, but also survey the details of long term contracts that have emerged from competitive bidding. Contracts provide a new level of specific detail that has not been previously available. 68 refs., 13 figs., 25 tabs.

  14. Dupuytren's Contracture: Fibroblast Contraction?

    PubMed Central

    Gabbiani, Giulio; Majno, Guido

    1972-01-01

    In 6 cases of Dupuytren's disease and 1 of Ledderhose's disease, the nodules of the palmar and plantar aponeurosis were examined by light and electron microscopy. The cells composing these nodules, presumably fibroblasts, showed three significant ultrastructural features: (1) a fibrillar system similar to that of smooth muscle cells; (2) nuclear deformations such as are found in contracted cells, the severest being recognizable by light microscopy (cross-banded nuclei); (3) cell-to-cell and cell-to-stroma attachments. Based on these data and on recent information about the biology of the fibroblasts, it is suggested that these cells are fibroblasts that have modulated into contractile cells (myofibroblasts), and that their contraction plays a role in the pathogenesis of the contracture observed clinically. ImagesFig 10Fig 5Fig 11Fig 6 and 7Fig 8Fig 1Fig 2Fig 9Fig 3Fig 4 PMID:5009249

  15. Russian Contract Procurement Document

    SciTech Connect

    Tobin, J G

    2010-03-29

    This contract supports the enhancement of physical protection or nuclear material control and accounting systems at institutes or enterprises of the newly independent states under the material protection control and accounting (MPC&A) program. The contract is entered into pursuant to the MPC&A Program, a gratuitous technical assistance program, in accordance with the bilateral Agreements between the Russian Federation and the United States of America concerning the Safe and Secure Transportation, Storage and Destruction of Weapons and the Prevention of Weapons Proliferation of June 1992, as extended and amended by Protocol signed of June 1999, Agreement between the Government of the Russian Federation regarding Cooperation in the Area of Nuclear Materials Physical Protection, Control and Accounting of October 1999 and the Russian Federation law of May 1999 on the taxation exemption of gratuitous technical assistance with Russian Federation under registration No.DOE001000.

  16. The Unwritten Contract

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Hosted by former STS-1 Astronaut Bob Crippen, this video highlights the Space Shuttle program team's commitment to quality assurance as being the unwritten contract all workers in the shuttle program have with the flight crews: To keep them and the whole Space Transportation System safe. The video is presented by the Marshall Space Flight Center's Safety, Reliability, Maintainability, and Quality Assurance Office (SRM&QA).

  17. Elements of gas contracts

    SciTech Connect

    O`Neal, J.

    1995-12-01

    The gas marketing scene has taken on a new look from the days of the {open_quotes}Long Term{close_quotes} or {open_quotes}Life of Lease{close_quotes} Contracts. In the past natural gas was of ten sold direct from the wellhead or a producer-owned facility to a pipeline company at a flat rate price and the only parties involved were producer or seller and buyer. Today, the parties involved in the marketing process might include a gathering entity to gather gas at a central point and provide gathering, compression and/or dehydration services; multiple pipeline companies for transportation; sales representatives or marketing brokers to negotiate a sale of the available gas on a monthly basis; and purchasers or end users. New terms have also been introduced in the process such as: {open_quotes}LDC{close_quotes} (local distribution company), {open_quotes}FERC Order 636{close_quotes}, {open_quotes}Price Delivered-to-Pipeline{close_quotes} and the various {open_quotes}levels of Service{close_quotes} under Gas Sales and Purchase Agreements. Four common levels of service are: {open_quotes}Firm{close_quotes}, {open_quotes}Baseload{close_quotes}, {open_quotes}Swing{close_quotes} and {open_quotes}Baseload/Operational{close_quotes}. It is evident that current marketing plans often require a separate contract for each service or commitment. Contract contents vary greatly, but most contain the following elements.

  18. Health Contract in the Classroom

    ERIC Educational Resources Information Center

    Haber, David

    2007-01-01

    A health contract is a technique used by health professionals to help clients achieve a health goal. This article describes a course, "Changing Health Behaviors," in which a health contract strategy is taught and practiced with older adults. The health contract can also be included as a smaller educational component within a gerontology course…

  19. How Learning Contracts Motivate Students

    ERIC Educational Resources Information Center

    Greenwood, Scott C.; McCabe, Patrick P.

    2008-01-01

    In this article, the authors discuss how learning contracts can motivate students. "A learning contract is simply a written agreement between teacher and learner in which the learner undertakes to complete mutually agreed upon tasks in a specified amount of time on his or her own initiative" (Greenwood, 2003, p.1). Contracts are designed to…

  20. 48 CFR 1842.7202 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES NASA Contractor Financial Management... Contractor Financial Management Reporting, in solicitations and contracts when any of the NASA Form...

  1. 48 CFR 1842.7202 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES NASA Contractor Financial Management... Contractor Financial Management Reporting, in solicitations and contracts when any of the NASA Form...

  2. tPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury.

    PubMed

    Armstead, William M; Riley, John; Yarovoi, Serge; Cines, Douglas B; Smith, Douglas H; Higazi, Abd Al-Roof

    2012-06-10

    Traumatic brain injury (TBI) is associated with loss of autoregulation due to impaired responsiveness to cerebrovascular dilator stimuli, which leads to cerebral hypoperfusion and neuronal impairment or death. Upregulation of tissue plasminogen activator (tPA) post-TBI exacerbates loss of cerebral autoregulation and NMDA-receptor-mediated impairment of cerebral hemodynamics, and enhances excitotoxic neuronal death. However, the relationship between NMDA-receptor activation, loss of autoregulation, and neurological dysfunction is unclear. Here, we evaluated the potential therapeutic efficacy of a catalytically inactive tPA variant, tPA S481A, that acts by competing with wild-type tPA for binding, cleavage, and activation of NMDA receptors. Lateral fluid percussion brain injury was produced in anesthetized piglets. Pial artery reactivity was measured via a closed cranial window, and cerebrospinal fluid (CSF) extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) was quantified by enzyme-linked immunosorbent assay (ELISA). tPA-S481A prevented impairment of cerebral autoregulation and reduced histopathologic changes after TBI by inhibiting upregulation of the ERK isoform of MAPK. Treatment with this tPA variant provides a novel approach for limiting neuronal toxicity caused by untoward NMDA-receptor activation mediated by increased tPA and glutamate following TBI. PMID:22435890

  3. 15. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) 1928 (Source: Vermont Agency of Transportation) DETAILS OF PORTALS AND TOP LATERALS - Jeffersonville Bridge, Spanning Lamoille River on Vermont Route 15, Cambridge, Lamoille County, VT

  4. 78 FR 7848 - Pennsylvania Disaster Number PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00057 AGENCY: U.S. Small Business Administration. ACTION.... ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration, Processing...

  5. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SECNAVINST 5210.8D). These reports shall be made available to PA program officials and to CNO (DNS-36)/CMC... until the next self-assessment is completed. Make these reports available, upon request, to CNO...

  6. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SECNAVINST 5210.8D). These reports shall be made available to PA program officials and to CNO (DNS-36)/CMC... until the next self-assessment is completed. Make these reports available, upon request, to CNO...

  7. Orion PA-1 Flight Test Crew Module Back at Dryden

    NASA Video Gallery

    The boilerplate Orion crew module and separation ring that was flown in the Launch Abort system PA-1 flight test at White Sands Missile Range, N.M., May 6 were airlifted back to NASA Dryden at Edwa...

  8. 76 FR 70528 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION... unchanged. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera,...

  9. 76 FR 70527 - Pennsylvania Disaster Number PA-00042

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00042 AGENCY: U.S. Small Business Administration. ACTION... unchanged. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera...

  10. 76 FR 61130 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION... remains unchanged. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) James E....

  11. 76 FR 68803 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION... in the original declaration remains unchanged. (Catalog of Federal Domestic Assistance Numbers...

  12. 76 FR 72994 - Pennsylvania Disaster Number PA-00045

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00045 AGENCY: U.S. Small Business Administration. ACTION... Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera, Associate Administrator for...

  13. 76 FR 47993 - Safety Zone; Allegheny River; Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... that will occur in the city of Pittsburgh, PA on August 6, 2011 (rain date August 7, 2011). Under 5 U.S... occur in the city of Pittsburgh, PA on August 6, 2011 (rain date August 7, 2011). Basis and Purpose The.... on August 6, 2011, with a rain date of August 7, 2011 from 9:30 p.m. to 11 p.m. The Captain of...

  14. Active Contraction of Microtubule Networks

    NASA Astrophysics Data System (ADS)

    Foster, Peter; Fürthauer, Sebastian; Shelley, Michael; Needleman, Daniel

    Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the large scale behaviors of these systems. Here we investigate the self-organization of stabilized microtubules in Xenopus oocyte extracts and find that they can form macroscopic networks that spontaneously contract. We propose that these contractions are driven by the clustering of microtubule minus ends by dynein. Based on this idea, we construct an active fluid theory of network contractions which predicts a dependence of the timescale of contraction on initial network geometry, a development of density inhomogeneities during contraction, a constant final network density, and a strong influence of dynein inhibition on the rate of contraction, all in quantitative agreement with experiments. These results demonstrate that the motor-driven clustering of filament ends is a generic mechanism leading to contraction.

  15. Active contraction of microtubule networks.

    PubMed

    Foster, Peter J; Fürthauer, Sebastian; Shelley, Michael J; Needleman, Daniel J

    2015-01-01

    Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the large-scale behaviors of these systems. Here, we investigate the self-organization of stabilized microtubules in Xenopus oocyte extracts and find that they can form macroscopic networks that spontaneously contract. We propose that these contractions are driven by the clustering of microtubule minus ends by dynein. Based on this idea, we construct an active fluid theory of network contractions, which predicts a dependence of the timescale of contraction on initial network geometry, a development of density inhomogeneities during contraction, a constant final network density, and a strong influence of dynein inhibition on the rate of contraction, all in quantitative agreement with experiments. These results demonstrate that the motor-driven clustering of filament ends is a generic mechanism leading to contraction. PMID:26701905

  16. The Lanthanide Contraction Revisited

    SciTech Connect

    Seitz, Michael; Oliver, Allen G.; Raymond, Kenneth N.

    2007-04-19

    A complete, isostructural series of lanthanide complexes (except Pm) with the ligand TREN-1,2-HOIQO has been synthesized and structurally characterized by means of single-crystal X-ray analysis. All complexes are 1D-polymeric species in the solid state, with the lanthanide being in an eight-coordinate, distorted trigonal-dodecahedral environment with a donor set of eight unique oxygen atoms. This series constitutes the first complete set of isostructural lanthanide complexes with a ligand of denticity greater than two. The geometric arrangement of the chelating moieties slightly deviates across the lanthanide series, as analyzed by a shape parameter metric based on the comparison of the dihedral angles along all edges of the coordination polyhedron. The apparent lanthanide contraction in the individual Ln-O bond lengths deviates considerably from the expected quadratic decrease that was found previously in a number of complexes with ligands of low denticity. The sum of all bond lengths around the trivalent metal cation, however, is more regular, showing an almost ideal quadratic behavior across the entire series. The quadratic nature of the lanthanide contraction is derived theoretically from Slater's model for the calculation of ionic radii. In addition, the sum of all distances along the edges of the coordination polyhedron show exactly the same quadratic dependency as the Ln-X bond lengths. The universal validity of this coordination sphere contraction, concomitant with the quadratic decrease in Ln-X bond lengths, was confirmed by reexamination of four other, previously published, almost complete series of lanthanide complexes. Due to the importance of multidentate ligands for the chelation of rare-earth metals, this result provides a significant advance for the prediction and rationalization of the geometric features of the corresponding lanthanide complexes, with great potential impact for all aspects of lanthanide coordination.

  17. 48 CFR 3035.7000 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SECURITY ACQUISITION REGULATION (HSAR) SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Information Dissemination by Educational Institutions 3035.7000 Contract clause. The contracting officer may use the clause at (HSAR) 48 CFR 3052.235-70, Dissemination of...

  18. 48 CFR 3035.7000 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SECURITY ACQUISITION REGULATION (HSAR) SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Information Dissemination by Educational Institutions 3035.7000 Contract clause. The contracting officer may use the clause at (HSAR) 48 CFR 3052.235-70, Dissemination of...

  19. 48 CFR 39.107 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY General 39.107 Contract clause. The contracting officer..., in solicitations and contracts for information technology which require security of information... information technology services or support services....

  20. 48 CFR 1235.7000 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in... Policy on Research Misconduct,” dated February 2002....

  1. 48 CFR 1235.7000 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in... Policy on Research Misconduct,” dated February 2002....

  2. 48 CFR 1235.7000 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in... Policy on Research Misconduct,” dated February 2002....

  3. 48 CFR 1632.617 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HEALTH BENEFITS ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Debts 1632.617 Contract clause. The clause at (FAR) 48 CFR 52.232-17 will be modified in all FEHBP...

  4. Detection of anthrax protective antigen (PA) using europium labeled anti-PA monoclonal antibody and time-resolved fluorescence.

    PubMed

    Stoddard, Robyn A; Quinn, Conrad P; Schiffer, Jarad M; Boyer, Anne E; Goldstein, Jason; Bagarozzi, Dennis A; Soroka, Stephen D; Dauphin, Leslie A; Hoffmaster, Alex R

    2014-06-01

    Inhalation anthrax is a rare but acute infectious disease following adsorption of Bacillus anthracis spores through the lungs. The disease has a high fatality rate if untreated, but early and correct diagnosis has a significant impact on case patient recovery. The early symptoms of inhalation anthrax are, however, non-specific and current anthrax diagnostics are primarily dependent upon culture and confirmatory real-time PCR. Consequently, there may be a significant delay in diagnosis and targeted treatment. Rapid, culture-independent diagnostic tests are therefore needed, particularly in the context of a large scale emergency response. The aim of this study was to evaluate the ability of monoclonal antibodies to detect anthrax toxin proteins that are secreted early in the course of B. anthracis infection using a time-resolved fluorescence (TRF) immunoassay. We selected monoclonal antibodies that could detect protective antigen (PA), as PA83 and also PA63 and LF in the lethal toxin complex. The assay reliable detection limit (RDL) was 6.63×10(-6)μM (0.551ng/ml) for PA83 and 2.51×10(-5)μM (1.58ng/ml) for PA63. Despite variable precision and accuracy of the assay, PA was detected in 9 out of 10 sera samples from anthrax confirmed case patients with cutaneous (n=7), inhalation (n=2), and gastrointestinal (n=1) disease. Anthrax Immune Globulin (AIG), which has been used in treatment of clinical anthrax, interfered with detection of PA. This study demonstrates a culture-independent method of diagnosing anthrax through the use of monoclonal antibodies to detect PA and LF in the lethal toxin complex. PMID:24857756

  5. TraceContract

    NASA Technical Reports Server (NTRS)

    Kavelund, Klaus; Barringer, Howard

    2012-01-01

    TraceContract is an API (Application Programming Interface) for trace analysis. A trace is a sequence of events, and can, for example, be generated by a running program, instrumented appropriately to generate events. An event can be any data object. An example of a trace is a log file containing events that a programmer has found important to record during a program execution. Trace - Contract takes as input such a trace together with a specification formulated using the API and reports on any violations of the specification, potentially calling code (reactions) to be executed when violations are detected. The software is developed as an internal DSL (Domain Specific Language) in the Scala programming language. Scala is a relatively new programming language that is specifically convenient for defining such internal DSLs due to a number of language characteristics. This includes Scala s elegant combination of object-oriented and functional programming, a succinct notation, and an advanced type system. The DSL offers a combination of data-parameterized state machines and temporal logic, which is novel. As an extension of Scala, it is a very expressive and convenient log file analysis framework.

  6. 48 CFR 17.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contracts. 17.204 Section 17.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify...

  7. 48 CFR 3417.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Contracts. 3417.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3417.204 Contracts. (e) Except as otherwise provided by law, contract periods that exceed the five-year limitation specified in FAR...

  8. 48 CFR 716.406 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clauses. 716.406 Section 716.406 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost Reimbursement Contracts 716.406 Contract clauses....

  9. 48 CFR 417.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Contracts. 417.204 Section 417.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting...

  10. 48 CFR 3417.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Contracts. 3417.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3417.204 Contracts. (e) Except as otherwise provided by law, contract periods that exceed the five-year limitation specified in FAR...

  11. 48 CFR 2017.204 - Contracts

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contracts 2017.204 Section 2017.204 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2017.204 Contracts (a) The contracting officer...

  12. 48 CFR 2017.204 - Contracts

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contracts 2017.204 Section 2017.204 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2017.204 Contracts (a) The contracting officer...

  13. 48 CFR 3416.603 - Letter contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Letter contracts. 3416.603... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 3416.603 Letter contracts....

  14. 48 CFR 2417.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contracts. 2417.204... CONTRACTING METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e)(1) The Senior Procurement Executive (SPE) is authorized to approve contract periods for other than...

  15. 48 CFR 817.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Contracts. 817.204 Section 817.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer...

  16. 48 CFR 3417.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contracts. 3417.204 Section... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3417.204 Contracts. (e) Except as otherwise provided by law, contract periods that exceed the five-year limitation specified in FAR...

  17. 48 CFR 817.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Contracts. 817.204 Section 817.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer...

  18. 48 CFR 3016.603 - Letter contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Letter contracts. 3016.603... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 3016.603 Letter contracts....

  19. 48 CFR 1817.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contracts. 1817.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option periods) applies to all NASA contracts regardless of type and...

  20. 48 CFR 17.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Contracts. 17.204 Section 17.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify...

  1. 48 CFR 2017.204 - Contracts

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contracts 2017.204 Section 2017.204 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2017.204 Contracts (a) The contracting officer...

  2. 48 CFR 4.103 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 4.103... MATTERS Contract Execution 4.103 Contract clause. The contracting officer shall insert the clause at 52.204-1, Approval of Contract, in solicitations and contracts if required by agency procedures....

  3. 48 CFR 1817.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contracts. 1817.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option periods) applies to all NASA contracts regardless of type and...

  4. 48 CFR 817.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contracts. 817.204 Section 817.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer...

  5. 48 CFR 16.307 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 16.307 Section 16.307 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.307 Contract clauses. (a)(1)...

  6. 48 CFR 2017.204 - Contracts

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contracts 2017.204 Section 2017.204 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2017.204 Contracts (a) The contracting officer...

  7. 48 CFR 3417.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Contracts. 3417.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3417.204 Contracts. (e) Except as otherwise provided by law, contract periods that exceed the five-year limitation specified in FAR...

  8. 48 CFR 817.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contracts. 817.204 Section 817.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer...

  9. 48 CFR 1817.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contracts. 1817.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option periods) applies to all NASA contracts regardless of type and...

  10. 48 CFR 2417.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contracts. 2417.204... CONTRACTING METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e) The Senior Procurement Executive shall approve any solicitation or contract which exceeds the five (5)...

  11. 48 CFR 417.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contracts. 417.204 Section 417.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting...

  12. 48 CFR 16.302 - Cost contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Cost contracts. 16.302 Section 16.302 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.302 Cost contracts....

  13. 48 CFR 16.406 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 16.406 Section 16.406 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 16.406 Contract clauses. (a) Insert...

  14. 48 CFR 1817.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contracts. 1817.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option periods) applies to all NASA contracts regardless of type and...

  15. 48 CFR 2417.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contracts. 2417.204... CONTRACTING METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e)(1) The Senior Procurement Executive (SPE) is authorized to approve contract periods for other than...

  16. 48 CFR 3417.70 - Modular contracting.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Modular contracting. 3417... REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Modular Contracting 3417.70 Modular contracting. (a) FSA—May incrementally conduct successive procurements of modules of...

  17. 48 CFR 2417.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contracts. 2417.204... CONTRACTING METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e) The Senior Procurement Executive shall approve any solicitation or contract which exceeds the five (5)...

  18. 48 CFR 17.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Contracts. 17.204 Section 17.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify...

  19. 48 CFR 17.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contracts. 17.204 Section 17.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify...

  20. 48 CFR 17.109 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 17.109 Section 17.109 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Multiyear Contracting 17.109 Contract clauses. (a)...

  1. 48 CFR 417.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Contracts. 417.204 Section 417.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting...

  2. 48 CFR 3437.670 - Contract type.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract type. 3437.670... SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Performance-Based Acquisition 3437.670 Contract type. Award-term contracting may be used for performance-based contracts and task orders that...

  3. 48 CFR 417.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Contracts. 417.204 Section 417.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting...

  4. 48 CFR 732.111 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clauses. 732.111... CONTRACTING REQUIREMENTS CONTRACT FINANCING General 732.111 Contract clauses. (a) (b) USAID may obtain short... indefinite quantity contracts that are a combination of contract types. Rather than using the...

  5. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract files. 4.802 Section 4.802 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract...

  6. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Contract files. 4.802 Section 4.802 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract...

  7. 48 CFR 937.7040 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CONTRACTING SERVICE CONTRACTING Protective Services Contracting 937.7040 Contract clauses. The contracting officer shall insert the clause at 952.237-70 entitled “Collective bargaining agreements—protective services” in all protective services solicitations and contracts involving DOE-owned facilities...

  8. 48 CFR 937.7040 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING SERVICE CONTRACTING Protective Services Contracting 937.7040 Contract clauses. The contracting officer shall insert the clause at 952.237-70 entitled “Collective bargaining agreements—protective services” in all protective services solicitations and contracts involving DOE-owned facilities...

  9. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Contract files. 4.802 Section 4.802 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract...

  10. 48 CFR 1846.470 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 1846.470 Contract clause. The contracting officer may insert a clause substantially as stated at 1852.246-71, Government Contract Quality Assurance Functions, in solicitations and contracts to specify the location(s) of quality...

  11. 48 CFR 1846.470 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 1846.470 Contract clause. The contracting officer may insert a clause substantially as stated at 1852.246-71, Government Contract Quality Assurance Functions, in solicitations and contracts to specify the location(s) of quality...

  12. 48 CFR 1416.405 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1416.405 Section 1416.405 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 1416.405 Contract clauses. The BPC, without the...

  13. 48 CFR 817.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracts. 817.204 Section 817.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer...

  14. 48 CFR 716.406 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 716.406 Section 716.406 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost Reimbursement Contracts 716.406 Contract clauses....

  15. 48 CFR 1517.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve a contract...

  16. 48 CFR 2017.204 - Contracts

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts 2017.204 Section 2017.204 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2017.204 Contracts (a) The contracting officer...

  17. 48 CFR 17.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contracts. 17.204 Section 17.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify...

  18. 48 CFR 417.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracts. 417.204 Section 417.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting...

  19. 48 CFR 732.111 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 732.111... CONTRACTING REQUIREMENTS CONTRACT FINANCING General 732.111 Contract clauses. (a) (b) USAID may obtain short... indefinite quantity contracts that are a combination of contract types. Rather than using the...

  20. 48 CFR 916.307 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 916.307 Section 916.307 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 916.307 Contract clauses. (g) Insert...

  1. 48 CFR 935.071 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clause. 935.071... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.071 Contract clause. The contracting officer must insert the clause at 952.235-71, Research Misconduct, in contracts, including management and...

  2. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract files. 4.802 Section 4.802 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract...

  3. 48 CFR 32.611 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 32.611 Section 32.611 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Debts 32.611 Contract clause. (a) The contracting officer shall...

  4. 231Pa systematics in postglacial volcanic rocks from Iceland

    NASA Astrophysics Data System (ADS)

    Turner, Simon; Kokfelt, Thomas; Hoernle, Kaj; Lundstrom, Craig; Hauff, Folkmar

    2016-07-01

    Several recent studies have highlighted the potential of combined 238U-230Th and 235U-231Pa systematics to constrain upwelling rates and the role of recycled mafic lithologies in mantle plume-derived basalts. Accordingly, we present measurements of the 231Pa concentrations from 26 mafic volcanic rocks from Iceland, including off-axis basalts from the Snaefellsnes Peninsula, to complement previously published 238U-230Th-226Ra data. 231Pa concentrations vary from 27 to 624 fg/g and (231Pa/235U) ratios from 1.12 to 2.11 with the exception of one anomalous sample from the Southeast Rift which has a 231Pa deficit with (231Pa/235U) = 0.86. An important new result is that basalts from the Southeast Rift and the Snaefellsnes Peninsula define a trend at relatively low (231Pa/235U) for a given (230Th/238U) ratio. Many of the remaining samples fall in or around the global field for ocean island basalts but those from the Mid-Iceland Belt and the Southwest Rift/Reykjanes Peninsula extend to higher (231Pa/235U) ratios at a given (230Th/238U), similar to mid-ocean ridge basalts. In principle, these lavas could result from melting of peridotite at lower pressures. However, there is no reason to suspect that the Mid-Iceland Belt and the Southwest Rift lavas reflect shallower melting than elsewhere in Iceland. In our preferred model, these lavas reflect melting of garnet peridotite whereas those from the Southeast Rift and the Snaefellsnes Peninsula contain a significant contribution (up to 20%) of melt from garnet pyroxenite. This is consistent with incompatible trace element and radiogenic isotope evidence for recycled oceanic crust in these lavas. There is increasing agreement that the displacement of ocean island basalts to lower (231Pa/235U) ratios at a given (230Th/238U), compared to mid-ocean ridge basalts, reflects the role of recycled mafic lithologies such as garnet pyroxenite as well as higher average pressures of melting. It now seems likely that this interpretation may

  5. Morphological studies on block copolymer modified PA 6 blends

    SciTech Connect

    Poindl, M. E-mail: christian.bonten@ikt.uni-stuttgart.de; Bonten, C. E-mail: christian.bonten@ikt.uni-stuttgart.de

    2014-05-15

    Recent studies show that compounding polyamide 6 (PA 6) with a PA 6 polyether block copolymers made by reaction injection molding (RIM) or continuous anionic polymerization in a reactive extrusion process (REX) result in blends with high impact strength and high stiffness compared to conventional rubber blends. In this paper, different high impact PA 6 blends were prepared using a twin screw extruder. The different impact modifiers were an ethylene propylene copolymer, a PA PA 6 polyether block copolymer made by reaction injection molding and one made by reactive extrusion. To ensure good particle matrix bonding, the ethylene propylene copolymer was grafted with maleic anhydride (EPR-g-MA). Due to the molecular structure of the two block copolymers, a coupling agent was not necessary. The block copolymers are semi-crystalline and partially cross-linked in contrast to commonly used amorphous rubbers which are usually uncured. The combination of different analysis methods like atomic force microscopy (AFM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) gave a detailed view in the structure of the blends. Due to the partial cross-linking, the particles of the block copolymers in the blends are not spherical like the ones of ethylene propylene copolymer. The differences in molecular structure, miscibility and grafting of the impact modifiers result in different mechanical properties and different blend morphologies.

  6. Morphological studies on block copolymer modified PA 6 blends

    NASA Astrophysics Data System (ADS)

    Poindl, M.; Bonten, C.

    2014-05-01

    Recent studies show that compounding polyamide 6 (PA 6) with a PA 6 polyether block copolymers made by reaction injection molding (RIM) or continuous anionic polymerization in a reactive extrusion process (REX) result in blends with high impact strength and high stiffness compared to conventional rubber blends. In this paper, different high impact PA 6 blends were prepared using a twin screw extruder. The different impact modifiers were an ethylene propylene copolymer, a PA PA 6 polyether block copolymer made by reaction injection molding and one made by reactive extrusion. To ensure good particle matrix bonding, the ethylene propylene copolymer was grafted with maleic anhydride (EPR-g-MA). Due to the molecular structure of the two block copolymers, a coupling agent was not necessary. The block copolymers are semi-crystalline and partially cross-linked in contrast to commonly used amorphous rubbers which are usually uncured. The combination of different analysis methods like atomic force microscopy (AFM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) gave a detailed view in the structure of the blends. Due to the partial cross-linking, the particles of the block copolymers in the blends are not spherical like the ones of ethylene propylene copolymer. The differences in molecular structure, miscibility and grafting of the impact modifiers result in different mechanical properties and different blend morphologies.

  7. Efficacy of histotripsy combined with rt-PA in vitro.

    PubMed

    Bader, Kenneth B; Haworth, Kevin J; Shekhar, Himanshu; Maxwell, Adam D; Peng, Tao; McPherson, David D; Holland, Christy K

    2016-07-21

    Histotripsy, a form of therapeutic ultrasound that uses the mechanical action of microbubble clouds for tissue ablation, is under development to treat chronic deep vein thrombosis (DVT). We hypothesize that combining thrombolytic agents with histotripsy will enhance clot lysis. Recombinant tissue plasminogen activator (rt-PA) and rt-PA-loaded echogenic liposomes that entrain octafluoropropane microbubbles (OFP t-ELIP) were used in combination with highly shocked histotripsy pulses. Fully retracted porcine venous clots, with similar features of DVT occlusions, were exposed either to histotripsy pulses alone (peak negative pressures of 7-20 MPa), histotripsy and OFP t-ELIP, or histotripsy and rt-PA. Microbubble cloud activity was monitored with passive cavitation imaging during histotripsy exposure. The power levels of cavitation emissions from within the clot were not statistically different between treatment types, likely due to the near instantaneous rupture and destruction of OFP t-ELIP. The thrombolytic efficacy was significantly improved in the presence of rt-PA. These results suggest the combination of histotripsy and rt-PA could serve as a potent therapeutic strategy for the treatment of DVT. PMID:27353199

  8. Efficacy of histotripsy combined with rt-PA in vitro

    NASA Astrophysics Data System (ADS)

    Bader, Kenneth B.; Haworth, Kevin J.; Shekhar, Himanshu; Maxwell, Adam D.; Peng, Tao; McPherson, David D.; Holland, Christy K.

    2016-07-01

    Histotripsy, a form of therapeutic ultrasound that uses the mechanical action of microbubble clouds for tissue ablation, is under development to treat chronic deep vein thrombosis (DVT). We hypothesize that combining thrombolytic agents with histotripsy will enhance clot lysis. Recombinant tissue plasminogen activator (rt-PA) and rt-PA-loaded echogenic liposomes that entrain octafluoropropane microbubbles (OFP t-ELIP) were used in combination with highly shocked histotripsy pulses. Fully retracted porcine venous clots, with similar features of DVT occlusions, were exposed either to histotripsy pulses alone (peak negative pressures of 7–20 MPa), histotripsy and OFP t-ELIP, or histotripsy and rt-PA. Microbubble cloud activity was monitored with passive cavitation imaging during histotripsy exposure. The power levels of cavitation emissions from within the clot were not statistically different between treatment types, likely due to the near instantaneous rupture and destruction of OFP t-ELIP. The thrombolytic efficacy was significantly improved in the presence of rt-PA. These results suggest the combination of histotripsy and rt-PA could serve as a potent therapeutic strategy for the treatment of DVT.

  9. Excited states of the odd-odd nucleus 230Pa

    NASA Astrophysics Data System (ADS)

    Kotthaus, T.; Reiter, P.; Hess, H.; Kalkühler, M.; Wendt, A.; Wiens, A.; Hertenberger, R.; Morgan, T.; Thirolf, P. G.; Wirth, H.-F.; Faestermann, T.

    2013-04-01

    The completely unknown spectrum of excited states of the odd-odd nucleus 230Pa was studied employing the one-neutron transfer reaction 231Pa(d,t)230Pa at a beam energy of 22 MeV. The excitation energy and the cross section were measured for, in total, 81 states below 1.4 MeV. Level assignments of these states are based on a semiempirical model and comparison with theoretical predictions, based on distorted-wave Born approximation (DWBA) calculations for the cross sections. For 12 rotational bands the band-head energy and the rotational parameter are determined. The K quantum numbers and the Nilsson configurations are established. Empirical values for the Gallagher-Moszkowski splittings and for Newby shifts are obtained.

  10. An electrooptical muscle contraction sensor.

    PubMed

    Chianura, Alessio; Giardini, Mario E

    2010-07-01

    An electrooptical sensor for the detection of muscle contraction is described. Infrared light is injected into the muscle, the backscattering is observed, and the contraction is detected by measuring the change, that occurs during muscle contraction, between the light scattered in the direction parallel and perpendicular to the muscle cells. With respect to electromyography and to optical absorption-based sensors, our device has the advantage of lower invasiveness, of lower sensitivity to electromagnetic noise and to movement artifacts, and of being able to distinguish between isometric and isotonic contractions. PMID:20490943

  11. Uterine Contraction Modeling and Simulation

    NASA Technical Reports Server (NTRS)

    Liu, Miao; Belfore, Lee A.; Shen, Yuzhong; Scerbo, Mark W.

    2010-01-01

    Building a training system for medical personnel to properly interpret fetal heart rate tracing requires developing accurate models that can relate various signal patterns to certain pathologies. In addition to modeling the fetal heart rate signal itself, the change of uterine pressure that bears strong relation to fetal heart rate and provides indications of maternal and fetal status should also be considered. In this work, we have developed a group of parametric models to simulate uterine contractions during labor and delivery. Through analysis of real patient records, we propose to model uterine contraction signals by three major components: regular contractions, impulsive noise caused by fetal movements, and low amplitude noise invoked by maternal breathing and measuring apparatus. The regular contractions are modeled by an asymmetric generalized Gaussian function and least squares estimation is used to compute the parameter values of the asymmetric generalized Gaussian function based on uterine contractions of real patients. Regular contractions are detected based on thresholding and derivative analysis of uterine contractions. Impulsive noise caused by fetal movements and low amplitude noise by maternal breathing and measuring apparatus are modeled by rational polynomial functions and Perlin noise, respectively. Experiment results show the synthesized uterine contractions can mimic the real uterine contractions realistically, demonstrating the effectiveness of the proposed algorithm.

  12. Oxidation of Gas-Phase Protactinium Ions, Pa+ and Pa2+: Formation and Properties of PaO22+(g), Protactinyl

    SciTech Connect

    Santos, M.; de Matos, A. Pires; Marcalo, J.; Gibson, John K; Haire, Richard {Dick} G; Tyagi, R.; Pitzer, R. M.

    2006-01-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N{sub 2}O to the relatively weak CH{sub 2}O - all oxidized Pa{sup +} to PaO{sup +} and PaO{sup +} to PaO{sub 2}{sup +}. On the basis of experimental observations, it was established that D[Pa{sup +}-O] and D[OPa{sup +}-O] {ge} 751 kJ mol{sup -1}. Estimates for D[Pa{sup +}-O], D[OPa{sup +}-O], IE[PaO], and IE[PaO{sub 2}] were also obtained. The seven oxidants reacted with Pa{sup 2+} to produce PaO{sup 2+}, indicating that D[Pa{sup 2+}-O] {ge} 751 kJ mol{sup -1}. A particularly notable finding was the oxidation of PaO{sup 2+} by N{sub 2}O to PaO{sub 2}{sup 2+}, a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO{sub 2}{sup 2+} suggested the protactinyl connectivity, {l_brace}O-Pa-O{r_brace}{sup 2+}. The experimentally determined IE[PaO{sub 2}{sup +}] {approx} 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO{sub 2}{sup +} and PaO{sub 2}{sup 2+}. These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial '6p hole' in the case of protactinyl. It was found that PaO{sub 2}{sup 2+} catalyzes the oxidation of CO by N{sub 2}O - such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO{sub 2}{sup 2+} is capable of activating H{sub 2} to form the stable PaO{sub 2}H{sup 2+} ion.

  13. Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA.

    PubMed

    Kleinschmidt-DeMasters, Bette K; Donson, Andrew M; Vogel, Hannes; Foreman, Nicholas K

    2015-07-01

    Pilomyxoid astrocytomas (PMAs) manifest a more aggressive clinical course than pilocytic astrocytomas (PAs). Development of effective therapies demands a better biological understanding of PMA. We first conducted gene expression microarray analysis of 9 PMA and 13 PA from infra- and supratentorial sites. Unsupervised hierarchical clustering analysis demonstrated that tumors are grouped according to anatomic site, not diagnosis. Gene expression profiles were then contrasted between eight PMAs and six PAs, all supratentorial/hypothalamic/chiasmal. Clinical outcome of PMAs varied, with four out of four patients with diencephalic syndrome succumbing to disease, one of whom showed bulky metastatic leptomeningeal spread at autopsy, with bimodal maturation to PA in some areas and de-differentiation to glioblastoma in others. A surviving child has undergone multiple surgical debulking, with progressive maturation to PA over time. Ontology-enrichment analysis identified overexpression in PMAs of extracellular matrix and mitosis-related genes. Genes overexpressed in PMA vs. PA, ranked according to fold-change, included developmental genes H19, DACT2, extracellular matrix collagens (COL2A1; COL1A1) and IGF2BP3 (IMP3), the latter previously identified as an adverse prognostic factor in PMA and PA. PMID:25521223

  14. Pilomyxoid astrocytoma (PMA) shows significant differences in gene expression versus pilocytic astrocytoma (PA) and variable tendency toward maturation to PA

    PubMed Central

    Kleinschmidt-DeMasters, B.K.; Donson, Andrew M.; Vogel, Hannes; Foreman, Nicholas K.

    2015-01-01

    Pilomyxoid astrocytomas (PMAs) manifest a more aggressive clinical course than pilocytic astrocytomas (PAs). Development of effective therapies demands a better biological understanding of PMA. We first conducted gene expression microarray analysis of 9 PMA and 13 PA from infra- and supra-tentorial sites. Unsupervised hierarchical clustering analysis demonstrated that tumors grouped according to anatomic site, not diagnosis. Gene expression profiles were then contrasted between 8 PMAs and 6 PAs, all supratentorial/hypothalamic/chiasmal. Clinical outcome of PMAs varied, with 4/4 patients with diencephalic syndrome succumbing to disease, one of whom showed bulky metastatic leptomeningeal spread at autopsy, with bimodal maturation to PA in some areas and de-differentiation to glioblastoma in others. A surviving child has undergone multiple surgical debulkings, with progressive maturation to PA over time. Ontology-enrichment analysis identified overexpression in PMAs of extracellular matrix and mitosis-related genes. Genes overexpressed in PMA versus PA, ranked according to fold-change, included developmental genes H19, DACT2, extracellular matrix collagens (COL2A1;COL1A1) and IGF2BP3 (IMP3), the latter previously identified as an adverse prognostic factor in PMA and PA. PMID:25521223

  15. 48 CFR 235.006 - Contracting methods and contract type.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... award a fixed-price type contract for a development program effort unless— (1) The level of program risk... allocation of program risk between the Government and the contractor; and (3) A written determination that... contract for the lead ship of a class; (2) A reduction in the amount of work under a fixed-price...

  16. Accreditation and implications of clinical postgraduate PA training programs.

    PubMed

    Hussaini, Sobia S; Bushardt, Reamer L; Gonsalves, Wanda C; Hilton, Virginia O; Hornberger, Brad J; Labagnara, Frank A; OʼHara, Kevin M; Sasek, Cody; Smith, Benjamin J; Williams, Jennifer S

    2016-05-01

    No consensus definition exists for postgraduate physician assistant (PA) training. This report from the AAPA Task Force on Accreditation of Postgraduate PA Training Programs describes the types of clinical training programs and their effects on hiring and compensation of PAs. Although completing a postgraduate program appears to have no effect on compensation, PAs who complete these programs may be favored in the hiring process and frequently report greater confidence in their skills. More research is needed and program accreditation is key to monitoring the effectiveness of these programs. PMID:27124222

  17. Modelling cerebral blood oxygenation using Monte Carlo XYZ-PA

    NASA Astrophysics Data System (ADS)

    Zam, Azhar; Jacques, Steven L.; Alexandrov, Sergey; Li, Youzhi; Leahy, Martin J.

    2013-02-01

    Continuous monitoring of cerebral blood oxygenation is critically important for the management of many lifethreatening conditions. Non-invasive monitoring of cerebral blood oxygenation with a photoacoustic technique offers advantages over current invasive and non-invasive methods. We introduce a Monte Carlo XYZ-PA to model the energy deposition in 3D and the time-resolved pressures and velocity potential based on the energy absorbed by the biological tissue. This paper outlines the benefits of using Monte Carlo XYZ-PA for optimization of photoacoustic measurement and imaging. To the best of our knowledge this is the first fully integrated tool for photoacoustic modelling.

  18. Shuttle GPS R/PA configuration and specification study

    NASA Technical Reports Server (NTRS)

    Booth, R. W. D.

    1979-01-01

    Changes in the technical specifications for a global positioning system (GPS) receiving system dedicated to space shuttle use are presented. Various hardware functions including acquisition, tracking, and measurement are emphasized. The anti-jam performance of the baseline GPS systems are evaluated. Other topics addressed include: the impact on R/PA design of the use of ground based transmitters; problems involved with the use of single channel tests sets; utility of various R/PA antenna interconnections topologies; the choice of the averaging interval for delta range measurements; and the use of interferometry techniques for the computation of orbiter attitude were undertaken.

  19. Courtship Contract In Marital Therapy

    ERIC Educational Resources Information Center

    Goldberg, Carl

    1975-01-01

    The courtship contracts serve as conceptual frames of reference to understand the normative structure and the psychodynamic components in distress. The contract established during courtship is explored in order to develop, during the time of marital crisis, explicitly negotiated standards. The goal is to re-educate the spouses to meet each others'…

  20. Using Contracts in Premarital Counseling.

    ERIC Educational Resources Information Center

    Martin, Don; Medler, Byron

    1980-01-01

    The premarital contract is an effective tool in premarital counseling. This contract is a written or verbal agreement that makes more explicit one's attitudes and expectations about aspects that will influence the marital relationship. Topics include division of labor, employment, financial responsibility, and religious beliefs and practices.…

  1. Policing Mechanisms in Agricultural Contracts

    ERIC Educational Resources Information Center

    Wolf, Steven; Hueth, Brent; Ligon, Ethan

    2001-01-01

    In this paper we focus on mechanisms of coordination in agricultural contracts. Our approach is intended to advance understanding of social relations of production and distribution of power in agrofood systems. Through an analysis of contracts between farmers and intermediaries (e.g., processors, shippers, consignment agents) for California fruits…

  2. Two Views on Performance Contracting.

    ERIC Educational Resources Information Center

    Lurie, Sylvia; Smith, Kenneth

    1996-01-01

    North Chicago, Illinois, District 187, received a districtwide overhaul of lighting, heating, ventilation, and security systems through a 10-year performance contract with the Honeywell Corporation. The Briarcliff Manor Union-Free School District, New York, has a contract with Johnson Controls that guarantees a portion of the energy savings…

  3. Contract Training in Community Colleges.

    ERIC Educational Resources Information Center

    Suchorski, Joan M.

    One of the most significant developments in higher education over the past decade has been the increased linkages between colleges and other organizations and institutions. A prominent and fast-growing form of linkage is contract training. Contract training refers to an arrangement in which a business, a government agency, or a community…

  4. Contract Education: A Background Paper.

    ERIC Educational Resources Information Center

    California Community Colleges, Sacramento. Academic Senate.

    Today contract education is generally thought of as a program or course for which an employer is paying the full cost of instruction for customized training. Contract education can help faculty remain current, encourage industry to make equipment available to the college that might otherwise be too expensive, and provide employment opportunities…

  5. CONTRACT ADMINISTRATIVE TRACKING SYSTEM (CATS)

    EPA Science Inventory

    The Contract Administrative Tracking System (CATS) was developed in response to an ORD NHEERL, Mid-Continent Ecology Division (MED)-recognized need for an automated tracking and retrieval system for Cost Reimbursable Level of Effort (CR/LOE) Contracts. CATS is an Oracle-based app...

  6. Development of a new dynamic gas flow-control system in the pressure range of 1 Pa-133 Pa

    SciTech Connect

    Hong, S. S.; Chung, J. W.; Khan, Wakil

    2011-12-15

    A new flow-control system (FCS-705) has been developed at Korea Research Institute of Standards and Science. The system is intended for calibration of vacuum gauges in the pressure range of 1 Pa-133 Pa by comparison method. This paper describes some basic characteristics of the system including; (1) the design and construction of the system, (2) the generation of stable pressures in the chamber, (3) achieving high upstream pressure limit by installing a short duct in the by-pass pumping line, and (4) investigation of the gas flow regimes within the short duct.

  7. Draft Genome Sequences of Pseudomonas fluorescens Strains PA4C2 and PA3G8 and Pseudomonas putida PA14H7, Three Biocontrol Bacteria against Dickeya Phytopathogens

    PubMed Central

    Cigna, Jérémy; Raoul des Essarts, Yannick; Mondy, Samuel; Hélias, Valérie; Beury-Cirou, Amélie

    2015-01-01

    Pseudomonas fluorescens strains PA4C2 and PA3G8 and Pseudomonas putida strain PA14H7 were isolated from potato rhizosphere and show an ability to inhibit the growth of Dickeya phytopathogens. Here, we report their draft genome sequences, which provide a basis for understanding the molecular mechanisms involved in antibiosis against Dickeya. PMID:25635023

  8. 78 FR 27025 - Modification of Class B Airspace; Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... rulemaking (NPRM) to modify the Philadelphia, PA, Class B airspace area (77 FR 45290, July 31, 2012...: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... aircraft within Class B airspace, reduce controller workload, and reduce the potential for midair...

  9. Women's weekend in ninth year. PinnacleHealth, Harrisburg, PA.

    PubMed

    Herreria, J

    1997-01-01

    For nine years, PinnacleHealth has lured busy women in the Harrisburg, Pa., area away for a weekend of pampering. It's a project of PinnacleHealth's WomanCare's Resource Center. The program began with 239 women, last year the event drew 400 participants. PMID:10174494

  10. 78 FR 12806 - Pennsylvania Disaster Number PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... ADMINISTRATION Pennsylvania Disaster Number PA-00057 AGENCY: U.S. Small Business Administration. ] ACTION.... ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration, Processing and..., Office of Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite...

  11. 78 FR 48297 - Amendment of Class E Airspace; Bedford, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... proposed rulemaking (NPRM) to amend Class E airspace at Bedford County Airport, Bedford, PA. (78 FR 32213...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...

  12. 78 FR 48296 - Amendment of Class E Airspace; Factoryville, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Field Airport, Factoryville, PA, (78 FR, 32212). Interested parties were invited to participate in this... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of...

  13. 75 FR 67911 - Amendment of Class E Airspace; Jeannette, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Jeannette, PA...

  14. ANALYSIS OF ATMOSPHERE DEPOSITION SAMPLES FROM EASTON, PA

    EPA Science Inventory

    The report gives results of an analysis of samples of tenacious atmospheric deposits on exposed surfaces (e.g., automobiles and houses) in an industrial area near Easton, PA. The analysis was made at the request of the State of Pennsylvania. The Pennsylvania Department of Environ...

  15. Existence under PA's Charter School Law: First Year Reports.

    ERIC Educational Resources Information Center

    Johnson, Addie M.

    This paper provides an update on how some new charter schools have fared during the first year of operation under Pennsylvania's charter school legislation (PA Act 22, June 1997). Data should facilitate an examination of the degree to which the legislation supports or inhibits the entrepreneurial school reform practice of charter schools. Twenty…

  16. Photofission of /sup 231/ Pa in the threshold region

    SciTech Connect

    Soldatov, A.S.; Rudnikov, V.E.; Aleksandrova, Z.A.; Smirenkin, G.N.; Tarasko, M.Z.

    1987-09-01

    Results are reported of yields, measured for the first time, and cross sections obtained from them for fission in the reaction /sup 231/ Pa(..gamma.., f ) for the ..gamma..-ray energy region 4.8--7.0 MeV.

  17. 75 FR 81469 - Safety Zone; Allegheny River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ...-2010-1082 and are available online by going to http://www.regulations.gov , inserting USCG-2010-1082 in.... 2064; Department of Homeland Security Delegation No. 0170.1. 0 2. Add Sec. 165.T08-1082 to read as follows: Sec. 165.T08-1082 Safety Zone; Allegheny River, Pittsburgh, PA. (a) Location. The following...

  18. 76 FR 59503 - Establishment of Class E Airspace; Lebanon, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... proposed rulemaking to amend Class E airspace 700 feet above the surface, at Lebanon, PA (76 FR 39038... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p....

  19. 77 FR 47792 - Drawbridge Operation Regulation; Schuylkill River, Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may submit a request... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Schuylkill River... River, mile 6.4 near Christian Street, at Philadelphia, PA. The proposed rule intends to change...

  20. 77 FR 63727 - Drawbridge Operation Regulation; Schuylkill River, Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... Operation Regulation; Schuylkill River, Philadelphia, PA in the FR (77 FR 47792). We received no comments on... FR Federal Register NPRM Notice of Proposed Rulemaking Sec. Section Symbol U.S.C. United States Code... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Schuylkill...

  1. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING...

  2. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING...

  3. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS AVAILABILITY OF DEPARTMENT OF THE NAVY RECORDS AND PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING...

  4. [Risk of contracting HIV].

    PubMed

    Becerra, Valeria Peixoto; Gaspar, Maria Filomena M; Alves, Maria Do Socorro C F

    2009-04-01

    The authors identify social activities related to the risk of contracting HIV in nursing students, bearing in mind their influence while using bio-secure methods, by means of an exploratory and qualitative study; 168 Superior School of Nursing in Lisbon, Portugal students participated in this study. Data were gathered by means of a Free Association Word Test which includes social demographic variables related to the participants. 90% of the 168 students in this study were female and 10% male. The majority 79,2%, of the participants age fell between 21 and 25 years and 97,6% of these participants were Portuguese. In the free association word test when responding to the stimulus HIV/AIDS, participants expressed disease (which is contagious in a clinical setting), and death as the awaited outcome for it. For the test term "risk of contagion when dealing with an AIDS patient" the participants often mentioned the words protection against contagion, as well as fear to contact blood and gloves as the main prevention method. To the stimulus measures of bio-security the words most frequently cited were glove as a protective measure in the context of professional activity and preservative (condom) to avoid contagion in other social contexts experienced by the participants. PMID:19554898

  5. INFINITY construction contract signed

    NASA Technical Reports Server (NTRS)

    2010-01-01

    Key state and community leaders celebrated April 6 with the signing of a construction contract for the state-of-the-art INFINITY Science Center planned near John C. Stennis Space Center in south Mississippi. Gulfport Mayor George Schloegel (l to r), chair of non-profit INFINITY Science Center Inc., was joined for the signing ceremony at the Hancock Bank in Gulfport by Virginia Wagner, sister of late Hancock Bank President Leo Seal Jr.; and Roy Anderson III, president and CEO of Roy Anderson Corp. Seal was the first chair of INFINITY Science Center Inc., which has led in development of the project. Roy Anderson Corp. plans to begin construction on the 72,000-square-foot, $28 million science and education center in May. The Mississippi Department of Transportation (MDOT) also is set to begin construction of a $2 million access road to the new center. The April 6 ceremony was attended by numerous officials, including former Stennis Space Center Directors Jerry Hlass and Roy Estess; Mississippi Senate President Pro Tempore Billy Hewes, R-Gulfport; Mississippi Rep. Diane Peranich, D-Pass Christian; and MDOT Southern District Commissioner Wayne Brown.

  6. Mechanobiology of lymphatic contractions.

    PubMed

    Munn, Lance L

    2015-02-01

    The lymphatic system is responsible for controlling tissue fluid pressure by facilitating flow of lymph (i.e. the plasma and cells that enter the lymphatic system). Because lymph contains cells of the immune system, its transport is not only important for fluid homeostasis, but also immune function. Lymph drainage can occur via passive flow or active pumping, and much research has identified the key biochemical and mechanical factors that affect output. Although many studies and reviews have addressed how tissue properties and fluid mechanics (i.e. pressure gradients) affect lymph transport [1-3] there is less known about lymphatic mechanobiology. As opposed to passive mechanical properties, mechanobiology describes the active coupling of mechanical signals and biochemical pathways. Lymphatic vasomotion is the result of a fascinating system affected by mechanical forces exerted by the flowing lymph, including pressure-induced vessel stretch and flow-induced shear stresses. These forces can trigger or modulate biochemical pathways important for controlling the lymphatic contractions. Here, I review the current understanding of lymphatic vessel function, focusing on vessel mechanobiology, and summarize the prospects for a comprehensive understanding that integrates the mechanical and biomechanical control mechanisms in the lymphatic system. PMID:25636584

  7. 48 CFR 41.205 - Separate contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Separate contracts. 41.205... CONTRACTING ACQUISITION OF UTILITY SERVICES Acquiring Utility Services 41.205 Separate contracts. (a) In the... services by separate contract subject to this part, and subject to agency contracting authority. (b) If...

  8. 48 CFR 617.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contracts. 617.204 Section 617.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 617.204 Contracts. (e) The Procurement Executive shall...

  9. 48 CFR 837.403 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clause. 837.403... OF CONTRACTING SERVICE CONTRACTING Nonpersonal Health Care Services 837.403 Contract clause. The contracting officer shall insert the clause at 852.237-7, Indemnification and medical liability insurance,...

  10. 48 CFR 1517.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve...

  11. 48 CFR 811.503 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 811.503... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Liquidated Damages 811.503 Contract clause. When the contracting... contracting officer must include the clause in 852.211-74, Liquidated damages, in the contract....

  12. 48 CFR 3432.705 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clauses. 3432.705 Section 3432.705 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 3432.705 Contract clauses....

  13. 48 CFR 1517.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve...

  14. 48 CFR 16.503 - Requirements contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Requirements contracts. 16.503 Section 16.503 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Indefinite-Delivery Contracts 16.503 Requirements...

  15. 7 CFR 800.198 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false Contracts. 800.198 Section 800.198 Agriculture..., Designations, Approvals, Contracts, and Conflicts of Interest § 800.198 Contracts. (a) Services contracted and who may apply. The Service may enter into a contract with any person, State, or governmental agency...

  16. 48 CFR 3416.307 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Acquisition Regulation (FAR)” from paragraph (a) and substituting “34 CFR part 74, Appendix E.” (b) The... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clauses. 3416.307... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 3416.307...

  17. 48 CFR 317.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  18. 48 CFR 16.603 - Letter contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Letter contracts. 16.603 Section 16.603 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts...

  19. 7 CFR 800.198 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Contracts. 800.198 Section 800.198 Agriculture..., Designations, Approvals, Contracts, and Conflicts of Interest § 800.198 Contracts. (a) Services contracted and who may apply. The Service may enter into a contract with any person, State, or governmental agency...

  20. 48 CFR 217.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contracts. 217.204 Section... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 217.204 Contracts. (e)(i) Notwithstanding FAR 17.204(e), the ordering period of a task order or delivery order...

  1. 7 CFR 800.198 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Contracts. 800.198 Section 800.198 Agriculture..., Designations, Approvals, Contracts, and Conflicts of Interest § 800.198 Contracts. (a) Services contracted and who may apply. The Service may enter into a contract with any person, State, or governmental agency...

  2. 29 CFR 4.107 - Federal contracts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Federal contracts. 4.107 Section 4.107 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the McNamara-O'Hara Service Contract Act Agencies Whose Contracts May Be Covered § 4.107 Federal contracts. (a) Section 2(a) of the...

  3. 48 CFR 317.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  4. 48 CFR 617.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Contracts. 617.204 Section 617.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 617.204 Contracts. (e) The Procurement Executive shall...

  5. 48 CFR 1517.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve...

  6. 24 CFR 232.605 - Contract requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Contract requirements. 232.605... Fire Safety Equipment Form of Contract § 232.605 Contract requirements. (a) The contract between the mortgagor and the general contractor may be in the form of either a lump sum contract or a cost...

  7. 7 CFR 800.198 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Contracts. 800.198 Section 800.198 Agriculture..., Designations, Approvals, Contracts, and Conflicts of Interest § 800.198 Contracts. (a) Services contracted and who may apply. The Service may enter into a contract with any person, State, or governmental agency...

  8. 42 CFR 434.40 - Contract requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Contract requirements. 434.40 Section 434.40 Public...) MEDICAL ASSISTANCE PROGRAMS CONTRACTS Contracts With Health Insuring Organizations § 434.40 Contract requirements. (a) Contracts with health insuring organizations that are not subject to the requirements...

  9. 48 CFR 217.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Contracts. 217.204 Section... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 217.204 Contracts. (e)(i) Notwithstanding FAR 17.204(e), the ordering period of a task order or delivery order...

  10. 48 CFR 1517.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve...

  11. 48 CFR 317.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  12. 7 CFR 632.22 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Contracts. 632.22 Section 632.22 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM Participation § 632.22 Contracts. (a) Cost-sharing contracts. A land user who has an approved reclamation plan may enter into a contract with NRCS...

  13. 7 CFR 632.22 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contracts. 632.22 Section 632.22 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM Participation § 632.22 Contracts. (a) Cost-sharing contracts. A land user who has an approved reclamation plan may enter into a contract with NRCS...

  14. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Contracts. 631.10 Section 631.10 Agriculture... AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a) To participate in the program, an applicant must enter into a contract agreeing to implement a conservation...

  15. 48 CFR 317.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  16. 48 CFR 4.1303 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 4.1303... ADMINISTRATIVE MATTERS Personal Identity Verification 4.1303 Contract clause. The contracting officer shall... and contracts when contract performance requires contractors to have routine physical access to...

  17. 48 CFR 822.305 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 822.305... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Contract Work Hours and Safety Standards Act 822.305 Contract clause. The contracting officer shall insert the clause at 852.222-70, Contract...

  18. 48 CFR 217.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Contracts. 217.204 Section... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 217.204 Contracts. (e)(i) Notwithstanding FAR 17.204(e), the ordering period of a task order or delivery order...

  19. 48 CFR 617.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Contracts. 617.204 Section 617.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 617.204 Contracts. (e) The Procurement Executive shall...

  20. 24 CFR 891.560 - HAP contract.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false HAP contract. 891.560 Section 891... Assistance § 891.560 HAP contract. (a) HAP contract. The housing assistance payments contract sets forth.... (b) HAP contract execution. (1) Upon satisfactory completion of the project, the Borrower and...

  1. 7 CFR 632.22 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Contracts. 632.22 Section 632.22 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM Participation § 632.22 Contracts. (a) Cost-sharing contracts. A land user who has an approved reclamation plan may enter into a contract with NRCS...

  2. 48 CFR 217.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contracts. 217.204 Section... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 217.204 Contracts. (e)(i) Notwithstanding FAR 17.204(e), the ordering period of a task order or delivery order...

  3. 48 CFR 837.403 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 837.403... OF CONTRACTING SERVICE CONTRACTING Nonpersonal Health Care Services 837.403 Contract clause. The contracting officer shall insert the clause at 852.237-7, Indemnification and medical liability insurance,...

  4. 7 CFR 632.22 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Contracts. 632.22 Section 632.22 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM Participation § 632.22 Contracts. (a) Cost-sharing contracts. A land user who has an approved reclamation plan may enter into a contract with NRCS...

  5. 48 CFR 617.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Contracts. 617.204 Section 617.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 617.204 Contracts. (e) The Procurement Executive shall...

  6. 48 CFR 970.3170 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 970.3170 Section 970.3170 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contract Cost Principles and Procedures 970.3170 Contract clause. The contracting officer...

  7. 7 CFR 1780.61 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true Construction contracts. 1780.61 Section 1780.61..., Constructing and Inspections § 1780.61 Construction contracts. Contract documents must be sufficiently.... (a) Standard construction contract documents. If the construction contract documents utilized are...

  8. 48 CFR 546.312 - Construction contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that...

  9. 48 CFR 546.312 - Construction contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that...

  10. 7 CFR 1780.61 - Construction contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 12 2012-01-01 2012-01-01 false Construction contracts. 1780.61 Section 1780.61..., Constructing and Inspections § 1780.61 Construction contracts. Contract documents must be sufficiently.... (a) Standard construction contract documents. If the construction contract documents utilized are...

  11. 48 CFR 546.312 - Construction contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that...

  12. 48 CFR 546.312 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Construction contracts... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that...

  13. 48 CFR 46.312 - Construction contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Construction contracts. 46... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.312 Construction contracts. The contracting officer shall insert the clause at 52.246-12, Inspection of Construction, in solicitations and contracts...

  14. 48 CFR 46.312 - Construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Construction contracts. 46... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.312 Construction contracts. The contracting officer shall insert the clause at 52.246-12, Inspection of Construction, in solicitations and contracts...

  15. 48 CFR 46.312 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Construction contracts. 46... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.312 Construction contracts. The contracting officer shall insert the clause at 52.246-12, Inspection of Construction, in solicitations and contracts...

  16. 7 CFR 1780.61 - Construction contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 12 2013-01-01 2013-01-01 false Construction contracts. 1780.61 Section 1780.61..., Constructing and Inspections § 1780.61 Construction contracts. Contract documents must be sufficiently.... (a) Standard construction contract documents. If the construction contract documents utilized are...

  17. 48 CFR 46.312 - Construction contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Construction contracts. 46... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.312 Construction contracts. The contracting officer shall insert the clause at 52.246-12, Inspection of Construction, in solicitations and contracts...

  18. 48 CFR 46.312 - Construction contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.312 Construction contracts. The contracting officer shall insert the clause at 52.246-12, Inspection of Construction, in solicitations and contracts for... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Construction contracts....

  19. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  20. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  1. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  2. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  3. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  4. 48 CFR 2442.1107 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract clause. 2442.1107 Section 2442.1107 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production Surveillance and Reporting 2442.1107 Contract clause. (a) The Contracting Officer...

  5. 48 CFR 2035.70 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 2035.70 Contract clauses. (a) The contracting officer shall insert the following clause in all solicitations and contracts for research and development by private..., Publication of Research Results; (2) Section 2052.235-72 Safety, Health and Fire Protection....

  6. 48 CFR 1235.7000 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Contract clause. 1235.7000 Section 1235.7000 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert...

  7. 48 CFR 1846.470 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clause. 1846.470 Section 1846.470 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 1846.470 Contract clause. The contracting officer may insert a...

  8. 48 CFR 1532.111 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contract clauses. 1532.111 Section 1532.111 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING General 1532.111 Contract clauses. The Contracting Officer...

  9. 46 CFR Sec. 3 - Terminal operating contract.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Terminal operating contract. Sec. 3 Section 3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION B-CONTROL AND UTILIZATION OF PORTS OPERATING CONTRACT Sec. 3 Terminal operating contract. Contract MA Terminal Operating Contract This agreement, made as of _________, 19__, between the...

  10. 48 CFR 317.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  11. 7 CFR 800.198 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Contracts. 800.198 Section 800.198 Agriculture..., Designations, Approvals, Contracts, and Conflicts of Interest § 800.198 Contracts. (a) Services contracted and who may apply. The Service may enter into a contract with any person, State, or governmental agency...

  12. 48 CFR 617.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracts. 617.204 Section 617.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 617.204 Contracts. (e) The Procurement Executive shall...

  13. 7 CFR 632.22 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Contracts. 632.22 Section 632.22 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM Participation § 632.22 Contracts. (a) Cost-sharing contracts. A land user who has an approved reclamation plan may enter into a contract with NRCS...

  14. 48 CFR 837.403 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 837.403... OF CONTRACTING SERVICE CONTRACTING Nonpersonal Health Care Services 837.403 Contract clause. The contracting officer shall insert the clause at 852.237-7, Indemnification and medical liability insurance,...

  15. 48 CFR 2417.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts. 2417.204 Section 2417.204 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CONTRACTING METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e) The...

  16. 48 CFR 217.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contracts. 217.204 Section... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 217.204 Contracts. (e)(i) Notwithstanding FAR 17.204(e), the ordering period of a task order or delivery order...

  17. 48 CFR 822.305 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 822.305... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Contract Work Hours and Safety Standards Act 822.305 Contract clause. The contracting officer shall insert the clause at 852.222-70, Contract...

  18. 48 CFR 811.503 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.503... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Liquidated Damages 811.503 Contract clause. When the contracting... contracting officer must include the clause in 852.211-74, Liquidated damages, in the contract....

  19. 24 CFR 891.560 - HAP contract.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false HAP contract. 891.560 Section 891... Assistance § 891.560 HAP contract. (a) HAP contract. The housing assistance payments contract sets forth.... (b) HAP contract execution. (1) Upon satisfactory completion of the project, the Borrower and...

  20. 48 CFR 937.7040 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., which prescribes use of the clause at 48 CFR 52.222-1, Notice to the Government of Labor Disputes. ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clauses. 937.7040... CONTRACTING SERVICE CONTRACTING Protective Services Contracting 937.7040 Contract clauses. The...

  1. 48 CFR 926.7104 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clause. 926.7104... 1993. 926.7104 Contract clause. The contracting officer shall insert the clause at 952.226-74, Displaced Employee Hiring Preference, in contracts (except for contracts for commercial items, pursuant...

  2. 48 CFR 1235.7000 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in all solicitations and contracts for research and development. For further information, see...

  3. 48 CFR 216.406 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Contract clauses. 216.406 Section 216.406 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts...

  4. 48 CFR 216.406 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contract clauses. 216.406 Section 216.406 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts...

  5. 48 CFR 216.406 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Contract clauses. 216.406 Section 216.406 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts...

  6. 48 CFR 216.406 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contract clauses. 216.406 Section 216.406 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts...

  7. 48 CFR 216.307 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Section 216.307 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 216.307 Contract clauses. (a) As required by section 827 of the National Defense Authorization Act...

  8. 48 CFR 1817.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts. 1817.204 Section 1817.204 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option...

  9. 48 CFR 232.617 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause. 232.617 Section 232.617 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Debts 232.617 Contract...

  10. 48 CFR 46.314 - Transportation contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Transportation contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.314 Transportation contracts. The contracting officer shall insert the clause at 52.246-14, Inspection of Transportation, in solicitations and contracts for...

  11. 48 CFR 46.314 - Transportation contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Transportation contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.314 Transportation contracts. The contracting officer shall insert the clause at 52.246-14, Inspection of Transportation, in solicitations and contracts for...

  12. 48 CFR 46.314 - Transportation contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Transportation contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.314 Transportation contracts. The contracting officer shall insert the clause at 52.246-14, Inspection of Transportation, in solicitations and contracts for...

  13. 48 CFR 46.314 - Transportation contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Transportation contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.314 Transportation contracts. The contracting officer shall insert the clause at 52.246-14, Inspection of Transportation, in solicitations and contracts for...

  14. 48 CFR 46.314 - Transportation contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Transportation contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.314 Transportation contracts. The contracting officer shall insert the clause at 52.246-14, Inspection of Transportation, in solicitations and contracts for...

  15. 48 CFR 2033.211 - Contract Claims-Contracting officer's decision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Contract Claims—Contracting officer's decision. The contracting officer shall alter the paragraph at FAR 33.211(a)(4)(v) to identify the Energy Board of Contract Appeals and include its address: U.S....

  16. Active contraction of microtubule networks

    PubMed Central

    Foster, Peter J; Fürthauer, Sebastian; Shelley, Michael J; Needleman, Daniel J

    2015-01-01

    Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the large-scale behaviors of these systems. Here, we investigate the self-organization of stabilized microtubules in Xenopus oocyte extracts and find that they can form macroscopic networks that spontaneously contract. We propose that these contractions are driven by the clustering of microtubule minus ends by dynein. Based on this idea, we construct an active fluid theory of network contractions, which predicts a dependence of the timescale of contraction on initial network geometry, a development of density inhomogeneities during contraction, a constant final network density, and a strong influence of dynein inhibition on the rate of contraction, all in quantitative agreement with experiments. These results demonstrate that the motor-driven clustering of filament ends is a generic mechanism leading to contraction. DOI: http://dx.doi.org/10.7554/eLife.10837.001 PMID:26701905

  17. 48 CFR 916.405 - Cost-reimbursement incentive contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... incentive contracts. 916.405 Section 916.405 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 916.405 Cost-reimbursement incentive contracts....

  18. 48 CFR 216.405 - Cost-reimbursement incentive contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... incentive contracts. 216.405 Section 216.405 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 216.405 Cost-reimbursement incentive contracts....

  19. 48 CFR 1316.405 - Cost-reimbursement incentive contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... incentive contracts. 1316.405 Section 1316.405 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 1316.405 Cost-reimbursement incentive contracts....

  20. 48 CFR 416.405 - Cost-reimbursement incentive contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... incentive contracts. 416.405 Section 416.405 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 416.405 Cost-reimbursement incentive contracts....

  1. 48 CFR 1816.405 - Cost-reimbursement incentive contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... incentive contracts. 1816.405 Section 1816.405 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 1816.405 Cost-reimbursement incentive contracts....

  2. 48 CFR 241.205 - Separate contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Separate contracts. 241... Services 241.205 Separate contracts. Follow the procedures at PGI 241.205 when acquiring utility services by separate contract....

  3. 48 CFR 2901.602 - Contracting officers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contracting officers. 2901... LABOR ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 2901.602 Contracting officers....

  4. 48 CFR 3030.201 - Contract requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract requirements. 3030... SECURITY ACQUISITION REGULATION (HSAR) GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 3030.201 Contract requirements....

  5. 48 CFR 1.602 - Contracting officers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contracting officers. 1... FEDERAL ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities 1.602 Contracting officers....

  6. 48 CFR 19.808 - Contract negotiation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract negotiation. 19... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 19.808 Contract negotiation....

  7. 48 CFR 822.305 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Hours and Safety Standards Act—nursing home care contract supplement, in solicitations and contracts for nursing home care when the FAR clause at 52.222-4, Contract Work Hours and Safety Standards...

  8. 48 CFR 822.305 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Hours and Safety Standards Act—nursing home care contract supplement, in solicitations and contracts for nursing home care when the FAR clause at 52.222-4, Contract Work Hours and Safety Standards...

  9. 48 CFR 822.305 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Hours and Safety Standards Act—nursing home care contract supplement, in solicitations and contracts for nursing home care when the FAR clause at 52.222-4, Contract Work Hours and Safety Standards...

  10. 48 CFR 10.003 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MARKET RESEARCH 10.003 Contract clause. The contracting officer shall insert the clause at 52.210-1, Market Research, in solicitations and contracts over $5 million for the procurement of items other...

  11. 77 FR 76091 - International Mail Contract

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is... international mail contract. This document invites public comments on the request and addresses several related... an expired International Business Reply Service (IBRS) competitive contract.\\1\\ The Postal...

  12. 48 CFR 19.808 - Contract negotiation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract negotiation. 19... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 19.808 Contract negotiation....

  13. 48 CFR 619.808 - Contract negotiation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract negotiation. 619... SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration (The 8(a) Program) 619.808 Contract negotiation....

  14. 48 CFR 1401.602 - Contracting officers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracting officers. 1401... DEPARTMENT OF THE INTERIOR ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 1401.602 Contracting officers....

  15. 48 CFR 1450.103 - Contract adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract adjustments. 1450.103 Section 1450.103 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT... Contract adjustments....

  16. Utility Energy Services Contracts: Enabling Documents

    SciTech Connect

    2009-05-01

    Utility Energy Services Contracts: Enabling Documents provides materials that clarify the authority for Federal agencies to enter into utility energy services contracts (UESCs), as well as sample documents and resources to ease utility partnership contracting.

  17. 48 CFR 246.710 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 246.710 Contract clauses. (1) Use a... contracts that include the clause at 252.227-7013, Rights in Technical Data and Computer Software,...

  18. Functionalization of PET and PA6.6 woven fabrics

    NASA Astrophysics Data System (ADS)

    Bessada, R.; Silva, G.; Paiva, M. C.; Machado, A. V.

    2011-07-01

    In the present work as received woven fabrics of polyethylene terephthalate (PET) and polyamide 6.6 (PA6.6) were exposed to a continuous dielectric barrier discharge (DBD), in air at atmospheric pressure, at selected discharge power values and conveyor speeds. The chemical modification of the fabric surface was studied by contact angle analysis, attenuated total reflection (ATR)-FTIR spectroscopy and X-ray photoelectron spectroscopy (XPS). The results confirmed that the treatment changed the fabric surface chemistry, increasing its wettability by polar liquids and its oxygen content. Contact angle results showed different behaviour of the two polymer fabrics toward ageing effects; while PET showed a contact angle increase along the subsequent days of treatment, the PA6.6 fabric maintained its hydrophilicity even 15 days after treatment. The surface morphology analysed by scanning electron microscopy (SEM), did not show any significant difference before and after treatment.

  19. Structure of a putative acetyltransferase (PA1377) from Pseudomonas aeruginosa

    SciTech Connect

    Davies, Anna M.; Tata, Renée; Chauviac, François-Xavier; Sutton, Brian J.; Brown, Paul R.

    2008-05-01

    The crystal structure of an acetyltransferase encoded by the gene PA1377 from Pseudomonas aeruginosa has been determined at 2.25 Å resolution. Comparison with a related acetyltransferase revealed a structural difference in the active site that was taken to reflect a difference in substrate binding and/or specificity between the two enzymes. Gene PA1377 from Pseudomonas aeruginosa encodes a 177-amino-acid conserved hypothetical protein of unknown function. The structure of this protein (termed pitax) has been solved in space group I222 to 2.25 Å resolution. Pitax belongs to the GCN5-related N-acetyltransferase family and contains all four sequence motifs conserved among family members. The β-strand structure in one of these motifs (motif A) is disrupted, which is believed to affect binding of the substrate that accepts the acetyl group from acetyl-CoA.

  20. A new antithrombogenic RV-PA valved conduit.

    PubMed

    Ichikawa, Y; Noishiki, Y; Soma, T; Ishii, M; Yamamoto, K; Takahashi, K; Mo, M; Kosuge, T; Kondo, J; Matsumoto, A

    1994-01-01

    A new antithrombogenic right ventricular (RV)-pulmonary artery (PA) valved conduit was developed using a bovine jugular vein containing a natural valve. To maintain the natural and mechanical properties of the venous tissue, a hydrophilic cross-linking reagent, glycerol polyglycidyl ether polyepoxy compound (PC) was used instead of glutaraldehyde (GA). Moreover, to induce antithrombogenicity, heparin was bonded to the inner surface of the bovine jugular vein cross-linked with PC. Conduits of 18 to 20 mm inner diameter (ID) were implanted between the RV and PA in nine dogs weighing 7-17 kg, with the native main PA being ligated proximally. The handling and suturing of the graft was easy and adaptable, and the anastomosis was completed with excellent coaptation and no blood leakage at the suture lines. All animals were chronic survivors, but one animal died of hematemesis on the 438th postoperative day. Grafts were explanted from 182 to 385 days after implantation. The luminal surface of the conduits were white, glistening, and smooth with good coaptation of the cusps, without calcification or degenerative changes except for one cusp that showed a minimal deformation with a small thrombus. Macroscopic and microscopic observation showed that there were no thrombi at the anastomotic lines, but small thrombi on the luminal surface of the conduits near the cusps and in some cusps. Endothelium-like cells were noticed on the luminal surface of the graft, except in the area near the cusps, and on one cusp at 196 days after surgery. These results indicated that the new RV-PA valved conduit provided adequate antithrombogenicity by temporary slow heparin release, followed later by endothelialization of the graft in a low pressure system at 1 year after implantation. PMID:8555607

  1. Demonstration Assessment of LED Roadway Lighting: Philadelphia, PA

    SciTech Connect

    Royer, Michael P.; Tuenge, Jason R.; Poplawski, Michael E.

    2012-09-01

    For this demonstration assessment, 10 different groups of LED luminaires were installed at three sites in Philadelphia, PA. Each of the three sites represented a different set of conditions, most importantly with regard to the incumbent HPS luminaires, which were nominally 100 W, 150 W, and 250 W. The performance of each product was evaluated based on manufacturer data, illuminance calculations, field measurements of illuminance, and the subjective impressions of both regular and expert observers.

  2. Possible ground-state octupole deformation in /sup 229/Pa

    SciTech Connect

    Ahmad, I.; Gindler, J.E.; Betts, R.R.; Chasman, R.R.; Friedman, A.M.

    1982-12-13

    Evidence is presented for the occurrence of a (5/2)/sup + -/ parity doublet as the ground state of /sup 229/Pa, in agreement with a previous theoretical prediction. The doublet splitting energy is measured to be 0.22 +- 0.05 keV. The relation of this doublet to ground-state octupole deformation is discussed. .ID LV2109 .PG 1762 1764

  3. Metlab Plant-Wide Assessment (Metlab in Wyndmoor, PA)

    SciTech Connect

    2002-08-01

    This OIT BestPractices case study describes the methods and results of a plant-wide energy assessment at Metlab's aircraft component manufacturing plant in Wyndmoor, PA. Recommendations derived from the assessment, if implemented, can save an estimated $528,400 annually, reduce natural gas use by 50,070 MMbtu per year, and reduce electrical use by 329,400 kWh per year.

  4. Commerical Remote Sensing Data Contract

    USGS Publications Warehouse

    U.S. Geological Survey

    2005-01-01

    The U. S. Geological Survey's (USGS) Commercial Remote Sensing Data Contracts (CRSDCs) provide government agencies with access to a broad range of commercially available remotely sensed airborne and satellite data. These contracts were established to support The National Map partners, other Federal Civilian agency programs, and Department of Defense programs that require data for the United States and its territories. Experience shows that centralized procurement of remotely sensed data leads to considerable cost savings to the Federal government through volume discounts, reduction of redundant contract administrative costs, and avoidance of duplicate purchases. These contracts directly support the President's Commercial Remote Sensing Space Policy, signed in 2003, by providing a centralized mechanism for civil agencies to acquire commercial remote sensing products to support their mission needs in an efficient and coordinated way. CRSDC administration is provided by the USGS Mid-Continent Mapping Center in Rolla, Missouri.

  5. Smooth Sailing with Contract Services.

    ERIC Educational Resources Information Center

    Fickes, Michael

    2001-01-01

    Discusses how to make the contract services relationship work smoothly for educational facilities. Covers topics of food, child care, and transportation services, along with a brief explanation of the benefits of outsourcing on-campus amenities. (GR)

  6. PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa

    PubMed Central

    Tan, Hao; Zhang, Lu; Weng, Yuding; Chen, Ronghao; Zhu, Feng; Jin, Yongxin; Cheng, Zhihui; Jin, Shouguang; Wu, Weihui

    2016-01-01

    Pseudomonas aeruginosa causes acute and chronic infections in human. Its increasing resistance to antibiotics requires alternative treatments that are more effective than available strategies. Among the alternatives is the unconventional usage of conventional antibiotics, of which the macrolide antibiotic azithromycin (AZM) provides a paradigmatic example. AZM therapy is associated with a small but consistent improvement in respiratory function of cystic fibrosis patients suffering from chronic P. aeruginosa infection. Besides immunomodulating activities, AZM represses bacterial genes involved in virulence, quorum sensing, biofilm formation, and motility, all of which are due to stalling of ribosome and depletion of cellular tRNA pool. However, how P. aeruginosa responds to and counteracts the effects of AZM remain elusive. Here, we found that deficiency of PA3297, a gene encoding a DEAH-box helicase, intensified AZM-mediated bacterial killing, suppression of pyocyanin production and swarming motility, and hypersusceptibility to hydrogen peroxide. We demonstrated that expression of PA3297 is induced by the interaction between AZM and ribosome. Importantly, mutation of PA3297 resulted in elevated levels of unprocessed 23S-5S rRNA in the presence of AZM, which might lead to increased susceptibility to AZM-mediated effects. Our results revealed one of the bacterial responses in counteracting the detrimental effects of AZM. PMID:27014238

  7. PA0148 from Pseudomonas aeruginosa Catalyzes the Deamination of Adenine

    SciTech Connect

    Goble, A.M.; Swaminathan, S.; Zhang, Z.; Sauder, J. M.; Burley, S. K.; Raushel, F. M.

    2011-08-02

    Four proteins from NCBI cog1816, previously annotated as adenosine deaminases, have been subjected to structural and functional characterization. Pa0148 (Pseudomonas aeruginosa PAO1), AAur1117 (Arthrobacter aurescens TC1), Sgx9403e, and Sgx9403g have been purified and their substrate profiles determined. Adenosine is not a substrate for any of these enzymes. All of these proteins will deaminate adenine to produce hypoxanthine with k{sub cat}/K{sub m} values that exceed 10{sup 5} M{sup -1} s{sup -1}. These enzymes will also accept 6-chloropurine, 6-methoxypurine, N-6-methyladenine, and 2,6-diaminopurine as alternate substrates. X-ray structures of Pa0148 and AAur1117 have been determined and reveal nearly identical distorted ({beta}/{alpha}){sub 8} barrels with a single zinc ion that is characteristic of members of the amidohydrolase superfamily. Structures of Pa0148 with adenine, 6-chloropurine, and hypoxanthine were also determined, thereby permitting identification of the residues responsible for coordinating the substrate and product.

  8. Pa0148 from Pseudomonas aeruginosa Catalyzes the Deamination of Adenine

    SciTech Connect

    A Goble; Z Zhang; J Sauder; S Burley; S Swaminathan; F Raushel

    2011-12-31

    Four proteins from NCBI cog1816, previously annotated as adenosine deaminases, have been subjected to structural and functional characterization. Pa0148 (Pseudomonas aeruginosa PAO1), AAur1117 (Arthrobacter aurescens TC1), Sgx9403e, and Sgx9403g have been purified and their substrate profiles determined. Adenosine is not a substrate for any of these enzymes. All of these proteins will deaminate adenine to produce hypoxanthine with k{sub cat}/K{sub m} values that exceed 10{sup 5} M{sup -1} s{sup -1}. These enzymes will also accept 6-chloropurine, 6-methoxypurine, N-6-methyladenine, and 2,6-diaminopurine as alternate substrates. X-ray structures of Pa0148 and AAur1117 have been determined and reveal nearly identical distorted ({beta}/{alpha}){sub 8} barrels with a single zinc ion that is characteristic of members of the amidohydrolase superfamily. Structures of Pa0148 with adenine, 6-chloropurine, and hypoxanthine were also determined, thereby permitting identification of the residues responsible for coordinating the substrate and product.

  9. Thermal degradation of PA66 during laser transmission welding

    NASA Astrophysics Data System (ADS)

    Wang, Xiao; Guo, Dehui; Chen, Guochun; Jiang, Hairong; Meng, Dongdong; Yan, Zhang; Liu, Huixia

    2016-09-01

    The thermal degradation of materials strongly influences the weld strength in laser transmission welding (LTW). Weld strength decreases at high temperatures because of material thermal degradation. Hence, it is necessary to investigate this phenomenon. Thermal degradation of polyamide 66 (PA66) was predicted by combining a pyrolysis kinetic model with a 3-D transient thermal model. Thermogravimetric analysis (TGA) was used to study the pyrolysis characteristic of PA66. The TGA data were used to obtain kinetic parameters of PA66 using an nth order model in MATLAB. In addition, material conversion as a function of temperature (time) was analyzed using this kinetic reaction model containing the relevant kinetic parameters. A 3-D transient thermal model based on a volumetric heat source was developed. The temperature-time data of the point located at the maximum temperature was predicted through this thermal analysis model under different weld parameters. This study demonstrates that the predicted power at which the material starts to degrade is generally consistent with the power at which shear strength begins to decrease. The present studies lay a theoretical foundation for the investigation of thermal degradation during LTW.

  10. PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa.

    PubMed

    Tan, Hao; Zhang, Lu; Weng, Yuding; Chen, Ronghao; Zhu, Feng; Jin, Yongxin; Cheng, Zhihui; Jin, Shouguang; Wu, Weihui

    2016-01-01

    Pseudomonas aeruginosa causes acute and chronic infections in human. Its increasing resistance to antibiotics requires alternative treatments that are more effective than available strategies. Among the alternatives is the unconventional usage of conventional antibiotics, of which the macrolide antibiotic azithromycin (AZM) provides a paradigmatic example. AZM therapy is associated with a small but consistent improvement in respiratory function of cystic fibrosis patients suffering from chronic P. aeruginosa infection. Besides immunomodulating activities, AZM represses bacterial genes involved in virulence, quorum sensing, biofilm formation, and motility, all of which are due to stalling of ribosome and depletion of cellular tRNA pool. However, how P. aeruginosa responds to and counteracts the effects of AZM remain elusive. Here, we found that deficiency of PA3297, a gene encoding a DEAH-box helicase, intensified AZM-mediated bacterial killing, suppression of pyocyanin production and swarming motility, and hypersusceptibility to hydrogen peroxide. We demonstrated that expression of PA3297 is induced by the interaction between AZM and ribosome. Importantly, mutation of PA3297 resulted in elevated levels of unprocessed 23S-5S rRNA in the presence of AZM, which might lead to increased susceptibility to AZM-mediated effects. Our results revealed one of the bacterial responses in counteracting the detrimental effects of AZM. PMID:27014238

  11. PA-30 Twin Comanche - NASA 808 in flight

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Dryden Flight Research Center's Piper PA-30 Twin Commanche, which helped validate the RPRV concept, descends to a remotely controlled landing on Rogers Dry Lake, unassisted by the onboard pilot. A Piper PA-30 Twin Commanche, known as NASA 808, was used at the NASA Dryden Flight Research Center as a rugged workhorse in a variety of research projects associated with both general aviation and military projects. In the early 1970s, the PA-30, serial number 301498, was used to test a flight technique used to fly Remotely Piloted Research Vehicles (RPRV's). The technique was first tested with the cockpit windows of the light aircraft blacked out while the pilot flew the aircraft utilizing a television monitor which gave him a 'pilot's eye' view ahead of the aircraft. Later pilots flew the aircraft from a ground cockpit, a procedure used with all RPRV's. TV and two-way telemetry allow the pilot to be in constant control of the aircraft. The apparatus mounted over the cockpit is a special fish eye lens camera, used to obtain images that are transmitted to the ground based cockpit. This project paved the way for sophisticated, highly successful research programs involving high risk spin, stall, and flight control conditions, such as the HiMAT and the subscale F-15 remotely piloted vehicles. Over the years, NASA 808 has also been used for spin and stall research related to general aviation aircraft and also research to alleviate wake vortices behind large jetliners.

  12. 48 CFR 1809.670 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Contractor Team Arrangements 1809.670 Contract... solicitations and contracts to clarify a contractor team arrangement where the prime contractor consists of...

  13. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  14. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  15. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  16. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  17. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  18. 48 CFR 801.602 - Contracting officers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... DEPARTMENT OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and... contracting authority. (7) Manage and enhance career development of the procurement work force. (8)...

  19. Maximising value from PFI contracts.

    PubMed

    Prosser, Karen; Gates, Russell

    2012-05-01

    Against a backdrop where the Coalition Government has said more 'value' needs to be squeezed out of existing healthcare PFI projects, Karen Prosser, head of the health sector team at built asset consultancy, EC Harris, and Russell Gates, one of the company's partners on the same team, set out some of the key elements that NHS Trusts with operational PFI contracts should consider when undertaking a contract savings review. PMID:22690514

  20. The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA

    PubMed Central

    Bavagnoli, Laura; Cucuzza, Stefano; Campanini, Giulia; Rovida, Francesca; Paolucci, Stefania; Baldanti, Fausto; Maga, Giovanni

    2015-01-01

    The PA protein of Influenza A virus (IAV) encoded by segment 3 acts as a specialized RNA endonuclease in the transcription of the viral genome. The same genomic segment encodes for a second shorter protein, termed PA-X, with the first 191 N-terminal aminoacids (aa) identical to PA, but with a completely different C-ter domain of 61 aa, due to a ribosomal frameshifting. In addition, it has been shown that several IAV isolates encode for a naturally truncated PA-X variant, PAXΔC20, missing the last 20 aa. The biochemical properties of PA-X and PAXΔC20 have been poorly investigated so far. Here, we have carried out an enzymatic characterization of PA-X and its naturally deleted form, in comparison with PA from the human IAV strain A/WSN/33 (H1N1). Our results showed, to the best of our knowledge for the first time, that PA-X possesses an endonucleolytic activity. Both PA and PA-X preferentially cut single stranded RNA regions, but with some differences. In addition, we showed that PAXΔC20 has severely reduced nuclease activity. These results point to a previously undetected role of the last C-ter 20 aa for the catalytic activity of PA-X and support distinct roles for these proteins in the viral life cycle. PMID:26384413

  1. The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA.

    PubMed

    Bavagnoli, Laura; Cucuzza, Stefano; Campanini, Giulia; Rovida, Francesca; Paolucci, Stefania; Baldanti, Fausto; Maga, Giovanni

    2015-10-30

    The PA protein of Influenza A virus (IAV) encoded by segment 3 acts as a specialized RNA endonuclease in the transcription of the viral genome. The same genomic segment encodes for a second shorter protein, termed PA-X, with the first 191 N-terminal aminoacids (aa) identical to PA, but with a completely different C-ter domain of 61 aa, due to a ribosomal frameshifting. In addition, it has been shown that several IAV isolates encode for a naturally truncated PA-X variant, PAXΔC20, missing the last 20 aa. The biochemical properties of PA-X and PAXΔC20 have been poorly investigated so far. Here, we have carried out an enzymatic characterization of PA-X and its naturally deleted form, in comparison with PA from the human IAV strain A/WSN/33 (H1N1). Our results showed, to the best of our knowledge for the first time, that PA-X possesses an endonucleolytic activity. Both PA and PA-X preferentially cut single stranded RNA regions, but with some differences. In addition, we showed that PAXΔC20 has severely reduced nuclease activity. These results point to a previously undetected role of the last C-ter 20 aa for the catalytic activity of PA-X and support distinct roles for these proteins in the viral life cycle. PMID:26384413

  2. 48 CFR 970.1504 - Contract pricing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract pricing. 970.1504 Section 970.1504 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contracting by Negotiation 970.1504 Contract pricing....

  3. 48 CFR 970.1504 - Contract pricing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract pricing. 970.1504 Section 970.1504 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contracting by Negotiation 970.1504 Contract pricing....

  4. 48 CFR 970.1504 - Contract pricing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Contract pricing. 970.1504 Section 970.1504 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contracting by Negotiation 970.1504 Contract pricing....

  5. 48 CFR 970.1504 - Contract pricing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Contract pricing. 970.1504 Section 970.1504 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contracting by Negotiation 970.1504 Contract pricing....

  6. 48 CFR 970.1504 - Contract pricing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract pricing. 970.1504 Section 970.1504 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contracting by Negotiation 970.1504 Contract pricing....

  7. 43 CFR 12.947 - Contract administration.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Contract administration. 12.947 Section 12... Requirements § 12.947 Contract administration. A system for contract administration shall be maintained to ensure contractor conformance with the terms, conditions and specifications of the contract and to...

  8. 48 CFR 2919.812 - Contract administration.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract administration... PROGRAMS SMALL BUSINESS AND SMALL DISADVANTAGED BUSINESS CONCERNS Contracting with the Small Business Administration (The 8(a) Program) 2919.812 Contract administration. (a) Contracting officers, or designees,...

  9. 43 CFR 402.9 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Contracts. 402.9 Section 402.9 Public... SALE OF LANDS IN FEDERAL RECLAMATION PROJECTS Public Lands § 402.9 Contracts. A contract in form... the United States by the Commissioner. A copy of the contract shall be furnished to the...

  10. 48 CFR 903.971 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clause. 903.971... Contract clause. The contracting officer shall insert the clause at 952.203-70, Whistleblower Protection for Contractor Employees, in contracts that involve work to be done on behalf of DOE directly...

  11. 48 CFR 22.1705 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 22.1705... Contract clause. (a) Insert the clause at 52.222-50, Combating Trafficking in Persons, in all solicitations and contracts. (b) Use the basic clause with its Alternate I when the contract will be...

  12. 12 CFR 239.41 - Employment contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Employment contracts. 239.41 Section 239.41... (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Indemnification; Employment Contracts § 239.41 Employment contracts. (a) General. A mutual holding company may enter into an employment contract with...

  13. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or...

  14. 48 CFR 53.111 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Contract clause. 53.111... AND FORMS FORMS General 53.111 Contract clause. Contracting officers shall insert the clause at 52.253-1, Computer Generated Forms, in solicitations and contracts that require the contractor to...

  15. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or...

  16. 43 CFR 12.947 - Contract administration.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Contract administration. 12.947 Section 12... Requirements § 12.947 Contract administration. A system for contract administration shall be maintained to ensure contractor conformance with the terms, conditions and specifications of the contract and to...

  17. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or...

  18. 48 CFR 3.202 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 3.202... Contract clause. The contracting officer shall insert the clause at 52.203-3, Gratuities, in solicitations and contracts with a value exceeding the simplified acquisition threshold, except those for...

  19. 48 CFR 22.610 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 22.610... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Walsh-Healey Public Contracts Act 22.610 Contract clause. The contracting officer shall insert the clause at 52.222-20, Walsh-Healey...

  20. 48 CFR 903.971 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 903.971... Contract clause. The contracting officer shall insert the clause at 952.203-70, Whistleblower Protection for Contractor Employees, in contracts that involve work to be done on behalf of DOE directly...

  1. 48 CFR 846.710 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clauses. 846.710 Section 846.710 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 846.710 Contract clauses. The contracting officer shall insert the clause...

  2. 48 CFR 11.503 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 11.503... DESCRIBING AGENCY NEEDS Liquidated Damages 11.503 Contract clauses. (a) Use the clause at 52.211-11... contracts for supplies, services, or research and development when the contracting officer determines...

  3. 48 CFR 8.1103 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract requirements. 8... PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Leasing of Motor Vehicles 8.1103 Contract requirements. Contracting officers shall include the following items in each contract for leasing motor vehicles: (a)...

  4. 7 CFR 1215.41 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Contracts. 1215.41 Section 1215.41 Agriculture..., Consumer Information, and Industry Information § 1215.41 Contracts. The Board shall not contract with any... and approved by the Secretary. Any contract or agreement shall provide that: (a) The contractor...

  5. 48 CFR 904.7201 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clause. 904.7201... MATTERS Public Affairs 904.7201 Contract clause. The contracting officer shall insert the clause at 952.204-75, Public Affairs, in solicitations and contracts that require the contractor to...

  6. 48 CFR 9.409 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 9.409... CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 9.409 Contract clause. The contracting... with Contractors Debarred, Suspended, or Proposed for Debarment, in solicitations and contracts...

  7. 29 CFR 95.47 - Contract administration.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Contract administration. 95.47 Section 95.47 Labor Office of... Procurement Standards § 95.47 Contract administration. A system for contract administration shall be maintained to ensure contractor conformance with the terms, conditions and specifications of the contract...

  8. 48 CFR 803.7001 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 803.7001... Practices 803.7001 Contract clause. The contracting officer shall insert the clause at 852.203-71, Display of Department of Veterans Affairs Hotline poster, in solicitations and contracts expected to equal...

  9. 48 CFR 2943.205 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clauses. 2943.205 Section 2943.205 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 2943.205 Contract clauses. HCAs may establish procedures, or office policies,...

  10. 7 CFR 1215.41 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Contracts. 1215.41 Section 1215.41 Agriculture..., Consumer Information, and Industry Information § 1215.41 Contracts. The Board shall not contract with any... and approved by the Secretary. Any contract or agreement shall provide that: (a) The contractor...

  11. 48 CFR 871.212 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clauses. 871.212... Rehabilitation and Employment Service 871.212 Contract clauses. Contracting officers must use the following clauses, as appropriate, in solicitations and contracts for vocational rehabilitation and...

  12. 48 CFR 19.1407 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 19.1407... Contract clauses. The contracting officer shall insert the clause 52.219-27, Notice of Total Service-Disabled Veteran-Owned Small Business Set-Aside, in solicitations and contracts for acquisitions under...

  13. 49 CFR 19.47 - Contract administration.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Contract administration. 19.47 Section 19.47... Requirements Procurement Standards § 19.47 Contract administration. A system for contract administration shall... contract and to ensure adequate and timely follow up of all purchases. Recipients shall evaluate...

  14. 29 CFR 4.190 - Contract cancellation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Contract cancellation. 4.190 Section 4.190 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Enforcement § 4.190 Contract cancellation. (a) As provided in section 3 of the Act, where a violation is found of any contract...

  15. 7 CFR 1215.41 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Contracts. 1215.41 Section 1215.41 Agriculture..., Consumer Information, and Industry Information § 1215.41 Contracts. The Board shall not contract with any... and approved by the Secretary. Any contract or agreement shall provide that: (a) The contractor...

  16. 7 CFR 1412.63 - Contract liability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Contract liability. 1412.63 Section 1412.63... CROP REVENUE ELECTION PROGRAM FOR THE 2008 AND SUBSEQUENT CROP YEARS Contract Violations and Reduction in Payments § 1412.63 Contract liability. All signatories to a DCP or ACRE program contract...

  17. 25 CFR 700.89 - Relocation contract.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Relocation contract. 700.89 Section 700.89 Indians THE... Policies and Instructions Definitions § 700.89 Relocation contract. The Relocation Contract is that contract signed by the head of household in which he/she agrees to purchase an existing house or...

  18. 25 CFR 700.89 - Relocation contract.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Relocation contract. 700.89 Section 700.89 Indians THE... Policies and Instructions Definitions § 700.89 Relocation contract. The Relocation Contract is that contract signed by the head of household in which he/she agrees to purchase an existing house or...

  19. 24 CFR 402.3 - Contract provisions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Contract provisions. 402.3 Section... URBAN DEVELOPMENT SECTION 8 PROJECT-BASED CONTRACT RENEWAL UNDER SECTION 524 OF MAHRA § 402.3 Contract provisions. The renewal HAP contract shall be construed and administered in accordance with all...

  20. 7 CFR 407.7 - The contract.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false The contract. 407.7 Section 407.7 Agriculture... AGRICULTURE AREA RISK PROTECTION INSURANCE REGULATIONS § 407.7 The contract. (a) The insurance contract shall... application for insurance on a form prescribed or approved by FCIC. (b) The contract shall consist of...

  1. 43 CFR 402.9 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Contracts. 402.9 Section 402.9 Public... SALE OF LANDS IN FEDERAL RECLAMATION PROJECTS Public Lands § 402.9 Contracts. A contract in form... the United States by the Commissioner. A copy of the contract shall be furnished to the...

  2. 2 CFR 200.22 - Contract.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Contract. 200.22 Section 200.22 Grants and... AWARDS Acronyms and Definitions Acronyms § 200.22 Contract. Contract means a legal instrument by which a... entity considers it a contract, when the substance of the transaction meets the definition of a...

  3. 10 CFR 600.147 - Contract administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Contract administration. 600.147 Section 600.147 Energy... Nonprofit Organizations Post-Award Requirements § 600.147 Contract administration. A system for contract... of the contract and to ensure adequate and timely follow up of all purchases. Recipients...

  4. 7 CFR 763.19 - Contract modification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Contract modification. 763.19 Section 763.19... AGRICULTURE SPECIAL PROGRAMS LAND CONTRACT GUARANTEE PROGRAM § 763.19 Contract modification. (a) The seller and buyer may modify the land contract to lower the interest rate and corresponding amortized...

  5. 8 CFR 233.1 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Contracts. 233.1 Section 233.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTRACTS WITH TRANSPORTATION LINES § 233.1 Contracts. The contracts with transportation lines referred to in section 233(c) of the Act may...

  6. 48 CFR 15.204 - Contract format.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract format. 15.204 Section 15.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information...

  7. 48 CFR 846.710 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clauses. 846.710 Section 846.710 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 846.710 Contract clauses. The contracting officer shall insert the clause...

  8. 36 CFR 1210.47 - Contract administration.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Contract administration. 1210... § 1210.47 Contract administration. A system for contract administration shall be maintained to ensure contractor conformance with the terms, conditions and specifications of the contract and to ensure...

  9. 48 CFR 4.404 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 4.404... MATTERS Safeguarding Classified Information Within Industry 4.404 Contract clause. (a) The contracting officer shall insert the clause at 52.204-2, Security Requirements, in solicitations and contracts...

  10. 48 CFR 7.404 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 7.404... ACQUISITION PLANNING Equipment Lease or Purchase 7.404 Contract clause. The contracting officer shall insert a... and contracts involving a lease with option to purchase....

  11. 48 CFR 11.703 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 11.703... DESCRIBING AGENCY NEEDS Variation in Quantity 11.703 Contract clauses. (a) The contracting officer shall insert the clause at 52.211-16, Variation in Quantity, in solicitations and contracts, if authorizing...

  12. 48 CFR 12.207 - Contract type.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract type. 12.207... ACQUISITION OF COMMERCIAL ITEMS Special Requirements for the Acquisition of Commercial Items 12.207 Contract... contracts or fixed-price contracts with economic price adjustment for the acquisition of commercial...

  13. 8 CFR 233.1 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Contracts. 233.1 Section 233.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTRACTS WITH TRANSPORTATION LINES § 233.1 Contracts. The contracts with transportation lines referred to in section 233(c) of the Act may...

  14. 48 CFR 871.212 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clauses. 871.212... Rehabilitation and Employment Service 871.212 Contract clauses. Contracting officers must use the following clauses, as appropriate, in solicitations and contracts for vocational rehabilitation and...

  15. 8 CFR 233.1 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Contracts. 233.1 Section 233.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTRACTS WITH TRANSPORTATION LINES § 233.1 Contracts. The contracts with transportation lines referred to in section 233(c) of the Act may...

  16. 43 CFR 402.9 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Contracts. 402.9 Section 402.9 Public... SALE OF LANDS IN FEDERAL RECLAMATION PROJECTS Public Lands § 402.9 Contracts. A contract in form... the United States by the Commissioner. A copy of the contract shall be furnished to the...

  17. 32 CFR 644.49 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Contracts. 644.49 Section 644.49 National Defense... Appraisal § 644.49 Contracts. (a) Appraisal reports. (1) Within their contract authority, Division and District Engineers may contract with recognized appraisal firms, corporations and individuals for...

  18. 48 CFR 12.303 - Contract format.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract format. 12.303... ACQUISITION OF COMMERCIAL ITEMS Solicitation Provisions and Contract Clauses for the Acquisition of Commercial Items 12.303 Contract format. Solicitations and contracts for the acquisition of commercial...

  19. 48 CFR 3004.103 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Contract Execution 3004.103 Contract clause. Insert the clause at (FAR) 48 CFR 52.204-1, Approval of Contract, in each solicitation where approval to... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clause....

  20. 43 CFR 12.947 - Contract administration.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Contract administration. 12.947 Section 12... Requirements § 12.947 Contract administration. A system for contract administration shall be maintained to ensure contractor conformance with the terms, conditions and specifications of the contract and to...

  1. 7 CFR 1470.26 - Contract renewal.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Contract renewal. 1470.26 Section 1470.26 Agriculture... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CONSERVATION STEWARDSHIP PROGRAM Contracts and Payments § 1470.26 Contract renewal. (a) At the end of an initial conservation stewardship contract, NRCS...

  2. 48 CFR 3402.201 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clause. 3402.201... GENERAL DEFINITIONS OF WORDS AND TERMS Definitions Clause 3402.201 Contract clause. The contracting... and contracts in which the clause at FAR 52.202-1 is required....

  3. 10 CFR 436.34 - Multiyear contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... subject to 48 CFR part 17, subpart 17.1, including the requirement that the contracting officer establish... 10 Energy 3 2014-01-01 2014-01-01 false Multiyear contracts. 436.34 Section 436.34 Energy... Procedures for Energy Savings Performance Contracting § 436.34 Multiyear contracts. (a) Subject to...

  4. 32 CFR 644.49 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Contracts. 644.49 Section 644.49 National... HANDBOOK Appraisal § 644.49 Contracts. (a) Appraisal reports. (1) Within their contract authority, Division and District Engineers may contract with recognized appraisal firms, corporations and individuals...

  5. 7 CFR 1466.21 - Contract requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Contract requirements. 1466.21 Section 1466.21... Contracts and Payments § 1466.21 Contract requirements. (a) In order for a participant to receive payments, the participant must enter into a contract agreeing to implement one or more conservation...

  6. 7 CFR 457.7 - The contract.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false The contract. 457.7 Section 457.7 Agriculture... AGRICULTURE COMMON CROP INSURANCE REGULATIONS § 457.7 The contract. The insurance contract shall become... insurance on a form prescribed by the Corporation. Changes made in the contract shall not affect...

  7. 43 CFR 402.9 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Contracts. 402.9 Section 402.9 Public Lands... LANDS IN FEDERAL RECLAMATION PROJECTS Public Lands § 402.9 Contracts. A contract in form approved by the... by the Commissioner. A copy of the contract shall be furnished to the appropriate land office of...

  8. 48 CFR 904.7201 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 904.7201... MATTERS Public Affairs 904.7201 Contract clause. The contracting officer shall insert the clause at 952.204-75, Public Affairs, in solicitations and contracts that require the contractor to...

  9. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or...

  10. 7 CFR 3019.47 - Contract administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Contract administration. 3019.47 Section 3019.47... Standards § 3019.47 Contract administration. A system for contract administration shall be maintained to ensure contractor conformance with the terms, conditions and specifications of the contract and to...

  11. 48 CFR 3042.7000 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the clause at (HSAR) 48 CFR 3052.242-72, Contracting Officer's Technical Representative, in... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clause. 3042.7000... SECURITY ACQUISITION REGULATION (HSAR) CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT...

  12. 7 CFR 550.49 - Contract administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contract administration. 550.49 Section 550.49... Agreements Procurement Standards § 550.49 Contract administration. A system for contract administration shall... contract and to ensure adequate and timely followup of all purchases. Recipients shall evaluate...

  13. 7 CFR 1463.109 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Contracts. 1463.109 Section 1463.109 Agriculture... Payment Program § 1463.109 Contracts. (a) CCC will enter into a contract with eligible tobacco quota holders and producers. To the extent a person has filed such a contract with CCC, but a...

  14. 48 CFR 11.701 - Supply contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Supply contracts. 11.701... DESCRIBING AGENCY NEEDS Variation in Quantity 11.701 Supply contracts. (a) A fixed-price supply contract may... of both; however, contracts for subsistence items may use other applicable terms of variation...

  15. 8 CFR 233.1 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Contracts. 233.1 Section 233.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTRACTS WITH TRANSPORTATION LINES § 233.1 Contracts. The contracts with transportation lines referred to in section 233(c) of the Act may...

  16. 48 CFR 811.404 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 811.404... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Delivery or Performance Schedules 811.404 Contract clause. When delivery is required by or on a particular date for f.o.b. destination contracts, the contracting...

  17. 7 CFR 1215.41 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Contracts. 1215.41 Section 1215.41 Agriculture..., Consumer Information, and Industry Information § 1215.41 Contracts. The Board shall not contract with any... and approved by the Secretary. Any contract or agreement shall provide that: (a) The contractor...

  18. 7 CFR 631.14 - Contract violations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contract violations. 631.14 Section 631.14 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.14 Contract...

  19. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contracts. 631.10 Section 631.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a)...

  20. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Contracts. 631.10 Section 631.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a)...

  1. 7 CFR 631.14 - Contract violations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Contract violations. 631.14 Section 631.14 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.14 Contract...

  2. 7 CFR 631.14 - Contract violations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Contract violations. 631.14 Section 631.14 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.14 Contract...

  3. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Contracts. 631.10 Section 631.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a)...

  4. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Contracts. 631.10 Section 631.10 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a)...

  5. 7 CFR 631.14 - Contract violations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Contract violations. 631.14 Section 631.14 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.14 Contract...

  6. 7 CFR 1780.61 - Construction contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false Construction contracts. 1780.61 Section 1780.61... AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS Planning, Designing, Bidding, Contracting, Constructing and Inspections § 1780.61 Construction contracts. Contract documents must be...

  7. 24 CFR 242.52 - Construction contracts.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract. A contract for the construction or substantial rehabilitation of a hospital shall be entered into by...

  8. 24 CFR 242.52 - Construction contracts.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract. A contract for the construction or substantial rehabilitation of a hospital shall be entered into by...

  9. 48 CFR 846.312 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Construction contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.312 Construction contracts. The contracting officer shall insert the clause at 852.236-74, 852.236-74, Inspection of construction, in solicitations and...

  10. 24 CFR 242.52 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract. A contract for the construction or substantial rehabilitation of a hospital shall be entered into by...

  11. 48 CFR 936.7101 - Construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Construction contracts... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Inspection and Acceptance 936.7101 Construction contracts. (a) Inspection services may be performed by the architect-engineer responsible for...

  12. 48 CFR 846.312 - Construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Construction contracts... MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.312 Construction contracts. The contracting officer shall insert the clause at 852.236-74, 852.236-74, Inspection of construction, in solicitations and...

  13. 48 CFR 936.7101 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Construction contracts... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Inspection and Acceptance 936.7101 Construction contracts. (a) Inspection services may be performed by the architect-engineer responsible for...

  14. 24 CFR 242.52 - Construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract. A contract for the construction or substantial rehabilitation of a hospital shall be entered into by...

  15. 48 CFR 846.312 - Construction contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.312 Construction contracts. The contracting officer shall insert the clause at 852.236-74, 852.236-74, Inspection of construction, in solicitations and contracts... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Construction...

  16. 48 CFR 546.312 - Construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 546.312 Construction contracts. Insert the clause at 552.246-72, Final Inspection and Tests, in solicitations and contracts for construction that include... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Construction...

  17. 48 CFR 846.312 - Construction contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.312 Construction contracts. The contracting officer shall insert the clause at 852.236-74, 852.236-74, Inspection of construction, in solicitations and contracts... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Construction...

  18. 24 CFR 242.52 - Construction contracts.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...; a construction management contract with a guaranteed maximum price, the final costs of which are... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract....

  19. 48 CFR 846.312 - Construction contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.312 Construction contracts. The contracting officer shall insert the clause at 852.236-74, 852.236-74, Inspection of construction, in solicitations and contracts... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Construction...

  20. 48 CFR 229.402 - Foreign contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Foreign contracts. 229.402 Section 229.402 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS TAXES Contract Clauses 229.402 Foreign contracts....