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Sample records for 5-ht-induced pa contraction

  1. Selective inhibitory effects of niflumic acid on 5-HT-induced contraction of the rat isolated stomach fundus.

    PubMed

    Scarparo, H C; Santos, G C; Leal-Cardoso, J H; Criddle, D N

    2000-06-01

    The effects of niflumic acid (NFA), an inhibitor of calcium-activated chloride currents I(Cl(Ca)), were compared with the actions of the voltage-dependent calcium channel (VDCC) blocker nifedipine on 5-hydroxtryptamine (5-HT)- and acetylcholine (ACh)-induced contractions of the rat isolated fundus. NFA (1 - 30 microM) elicited a concentration-dependent inhibition of contractions induced by 5-HT (10 microM) with a reduction to 15. 5+/-6.0% of the control value at 30 microM. 1 microM nifedipine reduced 5-HT-induced contraction to 15.2+/-4.9% of the control, an effect not greater in the additional presence of 30 microM NFA. In contrast, the contractile response to ACh (10 microM) was not inhibited by NFA in concentrations contraction induced by either 20 mM or 60 mM KCl, suggesting that this drug was not acting via blockade of VDCCs or activation of potassium channels. In contrast, 3, 5-dichlorophenylamine-2-carboxylic acid and 4, 4'-diisothiocyanatostilbene-2,2'-disulphonic acid were less selective in their inhibitory effects, inducing reductions of 60 mM KCl-induced contraction at concentrations >/=10 microM. Our results show that NFA can exert selective inhibitory effects on the chloride-dependent 5-HT-induced contractions of the rat fundus. The data support the hypothesis that activation of Cl((Ca)) channels leading to calcium entry via VDCCs is a mechanism utilized by 5-HT, but not by ACh, to elicit contraction of the rat fundus.

  2. Selective inhibitory effects of niflumic acid on 5-HT-induced contraction of the rat isolated stomach fundus

    PubMed Central

    Scarparo, H C; Santos, G C M; Leal-Cardoso, J H; Criddle, D N

    2000-01-01

    The effects of niflumic acid (NFA), an inhibitor of calcium-activated chloride currents ICl(Ca), were compared with the actions of the voltage-dependent calcium channel (VDCC) blocker nifedipine on 5-hydroxtryptamine (5-HT)- and acetylcholine (ACh)-induced contractions of the rat isolated fundus.NFA (1–30 μM) elicited a concentration-dependent inhibition of contractions induced by 5-HT (10 μM) with a reduction to 15.5±6.0% of the control value at 30 μM. 1 μM nifedipine reduced 5-HT-induced contraction to 15.2±4.9% of the control, an effect not greater in the additional presence of 30 μM NFA.In contrast, the contractile response to ACh (10 μM) was not inhibited by NFA in concentrations ⩽100 μM, although this response was partly inhibited by nifedipine (1 μM) to 67.6±11.8% of the control value.NFA (1–30 μM) did not affect contraction induced by either 20 mM or 60 mM KCl, suggesting that this drug was not acting via blockade of VDCCs or activation of potassium channels. In contrast, 3,5-dichlorophenylamine-2-carboxylic acid and 4,4′-diisothiocyanatostilbene-2,2′-disulphonic acid were less selective in their inhibitory effects, inducing reductions of 60 mM KCl-induced contraction at concentrations ⩾10 μM.Our results show that NFA can exert selective inhibitory effects on the chloride-dependent 5-HT-induced contractions of the rat fundus. The data support the hypothesis that activation of Cl(Ca) channels leading to calcium entry via VDCCs is a mechanism utilized by 5-HT, but not by ACh, to elicit contraction of the rat fundus. PMID:10821798

  3. Role of basal extracellular Ca2+ entry during 5-HT-induced vasoconstriction of canine pulmonary arteries

    PubMed Central

    Wilson, Sean M; Mason, Helen S; Ng, Lih C; Montague, Stephen; Johnston, Louise; Nicholson, Neil; Mansfield, Sarah; Hume, Joseph R

    2005-01-01

    Measurements of artery contraction, cytosolic [Ca2+], and Ca2+ permeability were made to examine contractile and cytosolic [Ca2+] responses of canine pulmonary arteries and isolated cells to 5-hydroxytryptamine (5-HT), and to determine the roles of intracellular Ca2+ release and extracellular Ca2+ entry in 5-HT responses. The EC50 for 5-HT-mediated contractions and cytosolic [Ca2+] increases was ∼10−7 M and responses were inhibited by ketanserin, a 5-HT2A-receptor antagonist. 5-HT induced cytosolic [Ca2+] increases were blocked by 20 μM Xestospongin-C and by 2-APB (IC50=32 μM), inhibitors of InsP3 receptor activation. 5-HT-mediated contractions were reliant on release of InsP3 but not ryanodine-sensitive Ca2+ stores. 5-HT-mediated contractions and cytosolic [Ca2+] increases were partially inhibited by 10 μM nisoldipine, a voltage-dependent Ca2+ channel blocker. Extracellular Ca2+ removal reduced 5-HT-mediated contractions further than nisoldipine and ablated cytosolic [Ca2+] increases and [Ca2+] oscillations. Similar to Ca2+ removal, Ni2+ reduced cytosolic [Ca2+] and [Ca2+] oscillations. Mn2+ quench of fura-2 and voltage-clamp experiments showed that 5-HT failed to activate any significant voltage-independent Ca2+ entry pathways, including store-operated and receptor-activated nonselective cation channels. Ni2+ but not nisoldipine or Gd3+ blocked basal Mn2+ entry. Voltage-clamp experiments showed that simultaneous depletion of both InsP3 and ryanodine-sensitive intracellular Ca2+ stores activates a current with linear voltage dependence and a reversal potential consistent with it being a nonselective cation channel. 5-HT did not activate this current. Basal Ca2+ entry, rather than CCE, is important to maintain 5-HT-induced cytosolic [Ca2+] responses and contraction in canine pulmonary artery. PMID:15655514

  4. Role of "Aplysia" Cell Adhesion Molecules during 5-HT-Induced Long-Term Functional and Structural Changes

    ERIC Educational Resources Information Center

    Han, Jin-Hee; Lim, Chae-Seok; Lee, Yong-Seok; Kandel, Eric R.; Kaang, Bong-Kiun

    2004-01-01

    We previously reported that five repeated pulses of 5-HT lead to down-regulation of the TM-apCAM isoform at the surface of "Aplysia" sensory neurons (SNs). We here examined whether apCAM down-regulation is required for 5-HT-induced long-term facilitation. We also analyzed the role of the cytoplasmic and extracellular domains by overexpressing…

  5. 42 CFR 434.6 - General requirements for all contracts and subcontracts. P>(a) Contracts. All contracts under...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false General requirements for all contracts and subcontracts. P>(a) Contracts. All contracts under this part must include all of the following: 434.6 Section... contracts and subcontracts.P>(a) Contracts. All contracts under this part must include all of the...

  6. 5-HT induces cAMP production in crypt colonocytes at a 5-HT4 receptor.

    PubMed

    Albuquerque, F C; Smith, E H; Kellum, J M

    1998-07-01

    Previous studies demonstrate that both 5-hydroxytryptamine (5-HT) and cyclic AMP (cAMP) induce chloride efflux from crypt colonocytes in the rat distal colon; antagonist studies suggest that the 5-HT response is mediated primarily by the 5-HT4 receptor. Since this receptor is known to be positively coupled to adenylate cyclase, we postulated that 5-HT should induce generation of cAMP, which should be inhibited by 5-HT4 antagonists. Method. Mucosal cells from rat distal colon were taken by a sequential calcium chelation technique for enrichment of crypt cells. Cytokeratin stains demonstrated that >99% of cells were colonocytes. [3H]Thymidine uptake studies demonstrate a fivefold increased incorporation in this cell preparation compared to earlier fractions. 3-Isobutyl-l-methylxanthine (IBMX, 100 microM) was added to all cell suspensions in order to prevent cAMP metabolism. Cell suspensions were incubated for 2 min at 37 degreesC with different concentrations of 5-HT (n = 7). cAMP was measured by enzyme immunoassay. In another series of experiments, 5-HT (0.3 microM) stimulation of cAMP was similarly measured in the presence and absence of 5-HT receptor antagonists: 10 microM 5-HTP-DP (5-HT1P; n = 4), 0.1 microM ketanserin (5-HT2A; n = 4), 0.3 microM ondansetron (5-HT3; n = 4), 3 microM tropisetron (5-HT3 and 5-HT4; n = 4), and 10 nM GR-113808 (5-HT4; n = 5). Results. 5-HT produced a dose-dependent increase in cAMP. The increase was significant at concentrations >/=0.3 microM when compared to cells incubated with IBMX alone. In the second series of experiment, 5-HT-induced generation of cAMP at a dose of 0.3 microM was significantly inhibited in the presence of GR-113808 and tropisetron. Conclusion. 5-HT acts at a 5-HT4 receptor to induce production of cAMP in rat distal crypt colonocytes.

  7. Contribution of PKC to the maintenance of 5-HT-induced short-term facilitation at sensorimotor synapses of Aplysia.

    PubMed

    Zhou, Lian; Baxter, Douglas A; Byrne, John H

    2014-10-15

    Aplysia sensorimotor synapses provide a useful model system for analyzing molecular processes that contribute to heterosynaptic plasticity. For example, previous studies demonstrated that multiple kinase cascades contribute to serotonin (5-HT)-induced short-term synaptic facilitation (STF), including protein kinase A (PKA) and protein kinase C (PKC). Moreover, the contribution of each kinase is believed to depend on the state of the synapse (e.g., depressed or nondepressed) and the time after application of 5-HT. Here, a previously unappreciated role for PKC-dependent processes was revealed to underlie the maintenance of STF at relatively nondepressed synapses. This PKC dependence was revealed when the synapse was stimulated repeatedly after application of 5-HT. The contributions of the PKA and PKC pathways were examined by blocking adenylyl cyclase-coupled 5-HT receptors with methiothepin and by blocking PKC with chelerythrine. STF was assessed 20 s after 5-HT application. The effects of PKC were consistent with enhanced mobilization of transmitter, as assessed by application of hypertonic sucrose solutions to measure the readily releasable pool of vesicles and recovery of the readily releasable pool after depletion. A computational model of transmitter release demonstrated that a PKC-dependent mobilization process was sufficient to explain the maintenance of STF at nondepressed synapses and the facilitation of depressed synapses.

  8. Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors

    PubMed Central

    Sánchez-López, Araceli; Centurión, David; Vázquez, Erika; Arulmani, Udayasankar; Saxena, Pramod R; Villalón, Carlos M

    2003-01-01

    Continuous infusions of 5-hydroxytryptamine (5-HT) inhibit the tachycardiac responses to preganglionic (C7-T1) sympathetic stimulation in pithed rats pretreated with desipramine. The present study identified the pharmacological profile of this inhibitory action of 5-HT. The inhibition induced by intravenous (i.v.) continuous infusions of 5-HT (5.6 μg kg−1 min−1) on sympathetically induced tachycardiac responses remained unaltered after i.v. treatment with saline or the antagonists GR 127935 (5-HT1B/1D), the combination of WAY 100635 (5-HT1A) plus GR 127935, ritanserin (5-HT2), tropisetron (5-HT3/4), LY215840 (5-HT7) or a cocktail of antagonists/inhibitors consisting of yohimbine (α2), prazosin (α1), ritanserin, GR 127935, WAY 100635 and indomethacin (cyclooxygenase), but was abolished by methiothepin (5-HT1/2/6/7 and recombinant 5-ht5A/5B). These drugs, used in doses high enough to block their respective receptors/mechanisms, did not modify the sympathetically induced tachycardiac responses per se. I.v. continuous infusions of the agonists 5-carboxamidotryptamine (5-CT; 5-HT1/7 and recombinant 5-ht5A/5B), CP 93,129 (r5-HT1B), sumatriptan (5-HT1B/1D), PNU-142633 (5-HT1D) and ergotamine (5-HT1B/1D and recombinant 5-ht5A/5B) mimicked the above sympatho-inhibition to 5-HT. In contrast, the agonists indorenate (5-HT1A) and LY344864 (5-ht1F) were inactive. Interestingly, 5-CT-induced cardiac sympatho-inhibition was abolished by methiothepin, the cocktail of antagonists/inhibitors, GR 127935 or the combination of SB224289 (5-HT1B) plus BRL15572 (5-HT1D), but remained unchanged when SB224289 or BRL15572 were given separately. Therefore, 5-HT-induced cardiac sympatho-inhibition, being unrelated to 5-HT2, 5-HT3, 5-HT4, 5-ht6, 5-HT7 receptors, α1/2-adrenoceptor or prostaglandin synthesis, seems to be primarily mediated by (i) 5-HT1 (probably 5-HT1B/1D) receptors and (ii) a novel mechanism antagonized by methiothepin that, most likely, involves putative 5-ht5A/5B

  9. Contractions

    MedlinePlus

    ... feel tightening of your uterus muscles at irregular intervals or a squeezing sensation in your lower abdomen ... beginning of childbirth. These contractions come at regular intervals, usually move from the back to the lower ...

  10. The effect of DA-9701 on 5-hydroxytryptamine-induced contraction of feline esophageal smooth muscle cells.

    PubMed

    Oh, Kyung Hoon; Nam, Yoonjin; Jeong, Ji Hoon; Kim, In Kyeom; Sohn, Uy Dong

    2014-04-22

    Serotonin, or 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter found in blood platelets, the gastrointestinal (GI) tract, and the central nervous system (CNS) of animals and humans. The signaling pathways of 5-hydroxytryptamine (5-HT)-induced contractions in cat esophageal smooth muscle cell (ESMC)s have been identified, but the downstream components of the 5-HT signaling pathway remain unclear. DA-9701 is the standardized extract of the Pharbitis nil Choisy seed (Pharbitidis Semen, Convolvulaceae) and the root of Corydalis yahusuo W.T. Wang (Corydalis Tuber, Papaveraceae). DA-9701 is known to have strong gastroprokinetic effects and a good safety profile. In this study, we investigated the 5-HT signaling pathway at the G-protein level, and we explored the mechanisms by which DA-9701 induces smooth muscle contraction. Freshly isolated smooth muscle cells were harvested from the feline esophagus, and cells were permeabilized to measure their length. 5-HT produced esophageal smooth muscle contractions in a dose-dependent manner. Furthermore, 5-HT produced a relatively long-acting contraction. 5-HT binds to the 5-HT2, 5-HT3 and 5-HT4 receptors to induce smooth muscle contraction in feline ESMCs. These receptors, which are located in esophageal smooth muscle, are coupled to Gαq, Gαo and Gαs. These G proteins activate PLC, which leads to Ca2+/calmodulin-dependent MLCK activation, resulting in MLC20 phosphorylation and cell contraction. Conversely, DA-9701 inhibits 5-HT-induced contraction by inhibiting MLC20 phosphorylation.

  11. 75 FR 43809 - Airworthiness Directives; Piper Aircraft, Inc. PA-28, PA-32, PA-34, and PA-44 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    .... PA-28, PA-32, PA- 34, and PA-44 Series Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... Aircraft, Inc. (Piper) PA-28, PA-32, PA-34, and PA-44 series airplanes. This AD requires you to inspect the... apply to certain Piper Aircraft, Inc. (Piper) PA-28, PA-32, PA- 34, and PA-44 series airplanes....

  12. Serotonin-induced muscle contraction in rat stomach fundus is mediated by a G alpha z-like guanine nucleotide binding protein.

    PubMed

    Wang, H Y; Eberle-Wang, K; Simansky, K J; Friedman, E

    1993-11-01

    Serotonin (5-HT) potently contracts the fundus of the rat stomach; however, the associated transduction pathway has not been described fully. Experiments were performed in an attempt to gain insight into the coupling mechanism associated with this fundal 5-HT receptor. 5-HT-stimulated [35S]GTP gamma S binding to a protein which was recognized by anti-G alpha Z antiserum in a Mg(++)-dependent fashion. 5-HT increased [35S]GTP gamma S binding in the fundus, but not in the corpus of the rat stomach. 5-HT also enhanced the binding of [alpha-32P]GTP to the fundal protein and increased the hydrolysis of GTP to GDP in fundal membranes. The fundal protein which binds GTP is 25 to 29 kDa in size whereas the brain G alpha Z protein which is recognized by the anti-G alpha Z antibody is a 41 kDa protein. Mixing experiments revealed that the fundal guanine nucleotide binding protein does not appear to be a proteolytic product of the 41 kDa G alpha Z protein. Activating protein kinase C with phorbol-12-myristate, 13-acetate induced a concentration-dependent, noncompetitive inhibition of [35S]GTP gamma S binding to the fundal protein, and of 5-HT-induced contraction of fundal strips. Phorbol-12-myristate, 13-acetate did not alter carbachol- or KCl-mediated fundus contraction. Furthermore, the activation of [35S]GTP gamma S binding by serotonergic agonists and its inhibition by pharmacological antagonists corresponded to the known actions of these agents on contraction of fundal muscle. The results provide evidence that the 5-HT receptor in the rat stomach fundus is coupled directly or indirectly to a G alpha z-like protein which may mediate 5-HT-induced contraction in this tissue.

  13. Comparative effects of niflumic acid and nifedipine on 5-hydroxytryptamine- and acetylcholine-induced contraction of the rat trachea.

    PubMed

    Teixeira, M C; Coelho, R R; Leal-Cardoso, J H; Criddle, D N

    2000-04-07

    The effects of niflumic acid, an inhibitor of Ca(2+)-activated Cl(-) (Cl((Ca))) channels, were compared with those of the voltage-dependent Ca(2+) channel (VDCC) blocker nifedipine on 5-hydroxytryptamine (5-HT)- and acetylcholine-induced contractions of the rat isolated trachea. Niflumic acid (3-100 microM) induced a concentration-dependent inhibition of 5-HT (10 microM)-induced contractions, with a reduction to 37.0+/-9.5% of the control at the highest concentration. One micromolar nifedipine, which completely blocked 60 mM KCl-induced contractions, reduced the response to 5-HT similarly to 39.2+/-11.5% of the control. The inhibition of the 5-HT response was not significantly different from that produced by the combined presence of nifedipine (1 microM) and niflumic acid (100 microM), suggesting that their effects were not additive. In contrast, neither niflumic acid (3-100 microM) nor nifedipine (1 microM) inhibited acetylcholine-induced contractions. The contraction to 5-HT (10 microM) in Cl(-)-free solution was decreased by more than approximately 85% of the control, whilst that of acetylcholine was reduced only by approximately 36%. Our data show that niflumic acid exerts selective inhibitory effects on 5-HT-induced contraction, and suggest that activation of Cl((Ca)) channels may be a mechanism whereby 5-HT (but not acetylcholine) induces Ca(2+) entry via VDCCs to elicit contraction.

  14. Contract Audit Followup: Its Impact on Defense Contracting.

    DTIC Science & Technology

    1983-12-01

    UNIT NUERS Naval Postgraduate School Monterey, California 93943 11. CONTROLLING OFFICE WANE AND ADDRESS 12. REPORT DATE Naval Postgraduate School...of control " Although many procurement managers and contracting offi- 4 cers have privately expressed their opinions of the contract audit followup...Management/ACO: Pesi qnes a manager of Adainistrative Contract- ing Officers. Managesent /PCO: Manager of Procuring Contracting Officers. Mangement/PA

  15. Schistosoma mansoni infection enhances host portal vein contraction: role of potassium channels and p38 MAP kinase.

    PubMed

    Araujo, F P; Quintas, L E M; Noël, F; Silva, C L M

    2007-07-01

    Murine Schistosoma mansoni infection is related to an increased contraction of portal vein in response to 5-hydroxytryptamine (5-HT). The present study addressed a putative alteration of ion channels and enzymes involved in vascular contraction. In control group, either inhibition of K+ channels sensitive to ATP (K(ATP)) or Ca2+ (BK(Ca)) increased 5-HT-induced contraction, but the same did not occur in infected mice. On the other hand, inhibition of p38 MAP kinase markedly decreased the vascular contraction to 5-HT in the infected mice with minor effects in the control group. Accordingly, we observed a higher density of phospho-p38 MAP kinase, that refers to the fully active state of the enzyme, in portal veins from infected mice as compared to control animals. These results suggest that the reduced function of K(ATP) and BK(Ca) channels along with an increased contribution of p38 MAP kinase contribute to the increased contraction of portal veins to 5-HT observed in murine schistosomiasis.

  16. PA Discussion Topics

    DTIC Science & Technology

    2011-02-04

    Vehicle Power & Mobility PA Discussion Topics UNCLASSIFIED: Dist A. Approved for public releas Report Documentation Page Form ApprovedOMB No. 0704...0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions...Headquarters Services, Directorate for Information Operations and Reports , 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302

  17. Potentiation by endothelin-1 of 5-hydroxytryptamine-induced contraction in coronary artery of the pig.

    PubMed Central

    Nakayama, K.; Ishigai, Y.; Uchida, H.; Tanaka, Y.

    1991-01-01

    1. In order to elucidate the physiological and potential pathological roles of endothelin-1 (ET-1) in coronary artery contraction and relaxation, we undertook the present study to examine the action of ET-1 itself, and the combined effects of ET-1 with vasoconstrictor agonists such as acetylcholine (ACh), histamine, and 5-hydroxytryptamine (5-HT), all of which have been implicated in the genesis of coronary spasm. 2. Isometric tension and cytosolic Ca2+ concentration ([Ca2+]i) in a ring segment of porcine coronary artery loaded with fura-2 were measured simultaneously. 3. ET-1 contracted the artery in a concentration-dependent manner; and nisoldipine, a Ca2+ channel blocking drug of the 1,4-dihydropyridine type, antagonized the ET-1 action non-competitively. A radio-receptor binding assay also indicated the mutually exclusive binding of ET-1 and (+)-[3H]-PN200-110, a Ca2+ channel ligand, to the membrane fraction of porcine coronary artery. 4. ET-1 (10-100 pM) increased tension and [Ca2+]i in a parallel manner, while at higher concentrations (1-10 nM) it produced further contraction with a small increase in [Ca2+]i. 5. ET-1 (30-100 pM) selectively potentiated the 5-HT-induced contraction 1.5 to 2 times over the control without causing a significant increase in [Ca2+]i, which seems to be qualitatively similar to a tumour promoting phorbol ester, 12-deoxyphorbol 13-isobutylate (DPB). Bay K 8644 (10 nM), on the other hand, potentiated the contraction in response to practically all agonists used and affected a concomitant increase in [Ca2+]i.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1810605

  18. Architect's Contract.

    ERIC Educational Resources Information Center

    Ohio State Board of Education, Columbus.

    An actual contract form used for architectural services is presented. Fees, duties, and services are included. Services are listed in the following phases--(1) schematic design, (2) design development, (3) contract document, and (4) construction. Extra services are listed, and owner's responsibility with regard to cost estimates is given.…

  19. Relaxant effects of Schisandra chinensis and its major lignans on agonists-induced contraction in guinea pig ileum.

    PubMed

    Yang, Jia-Ming; Ip, Paul Siu Po; Che, Chun-Tao; Yeung, John H K

    2011-10-15

    In this study, the herbal extracts of Schisandra chinensis were demonstrated to inhibit the contractions induced by acetylcholine (ACh) and serotonin (5-HT) in guinea pig ileum, and the 95% ethanol extract was more effective than the aqueous extract. Analysis with High Performance Liquid Chromatography (HPLC) indicated that schisandrin, schisandrol B, schisandrin A and schisandrin B were the major lignans of Schisandra chinensis, and the ethanol extract contained higher amount of these lignans than the aqueous extract. All four lignans inhibited the contractile responses to ACh, with EC(20) values ranging from 2.2±0.4μM (schisandrin A) to 13.2±4.7μM (schisandrin). The effectiveness of these compounds in relaxing the 5-HT-induced contraction was observed with a similar magnitude. Receptor binding assay indicated that Schisandra lignans did not show significant antagonistic effect on muscarinic M3 receptor. In Ca(2+)-free preparations primed with ACh or KCl, schisandrin A (50μM) attenuated the contractile responses to cumulative addition of CaCl(2) by 37%. In addition, schisandrin A also concentration-dependently inhibited ACh-induced contractions in Ca(2+)-free buffer. This study demonstrates that Schisandra chinensis exhibited relaxant effects on agonist-induced contraction in guinea pig ileum, with schisandrin, schisandrol B, schisandrin A and schisandrin B being the major active ingredients. The antispasmodic action of schisandrin A involved inhibitions on both Ca(2+) influx through L-type Ca(2+) channels and intracellular Ca(2+) mobilization, rather than specific antagonism of cholinergic muscarinic receptors.

  20. PaR-PaR laboratory automation platform.

    PubMed

    Linshiz, Gregory; Stawski, Nina; Poust, Sean; Bi, Changhao; Keasling, Jay D; Hillson, Nathan J

    2013-05-17

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

  1. PaR-PaR Laboratory Automation Platform

    SciTech Connect

    Linshiz, G; Stawski, N; Poust, S; Bi, CH; Keasling, JD; Hilson, NJ

    2013-05-01

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

  2. Mediation of 5-HT-induced external carotid vasodilatation in GR 127935-pretreated vagosympathectomized dogs by the putative 5-HT7 receptor

    PubMed Central

    Villalón, Carlos M; Centurión, David; Luján-Estrada, Miguel; Terrón, José A; Sánchez-López, Araceli

    1997-01-01

    The vasodilator effects of 5-hydroxytryptamine (5-HT) in the external carotid bed of anaesthetized dogs with intact sympathetic tone are mediated by prejunctional sympatho-inhibitory 5-HT1B/1D receptors and postjunctional 5-HT receptors. The prejunctional vasodilator mechanism is abolished after vagosympathectomy which results in the reversal of the vasodilator effect to vasoconstriction. The blockade of this vasoconstrictor effect of 5-HT with the 5-HT1B/1D receptor antagonist, GR 127935, unmasks a dose-dependent vasodilator effect of 5-HT, but not of sumatriptan. Therefore, the present study set out to analyse the pharmacological profile of this postjunctional vasodilator 5-HT receptor in the external carotid bed of vagosympathectomized dogs pretreated with GR 127935 (20 μg kg−1, i.v.).One-minute intracarotid (i.c.) infusions of 5-HT (0.330 μg min−1), 5-carboxamidotryptamine (5-CT; 0.010.3 μg min−1), 5-methoxytryptamine (1100 μg min−1) and lisuride (31000 μg min−1) resulted in dose-dependent increases in external carotid blood flow (without changes in blood pressure or heart rate) with a rank order of agonist potency of 5-CT>>5-HT⩾5-methoxytryptamine>lisuride, whereas cisapride (1001000 μg min−1, i.c.) was practically inactive. Interestingly, lisuride (mean dose of 85±7 μg kg−1, i.c.), but not cisapride (mean dose of 67±7 μg kg−1, i.c.), specifically abolished the responses induced by 5-HT, 5-CT and 5-methoxytryptamine, suggesting that a common site of action may be involved. In contrast, 1 min i.c. infusions of 8-OH-DPAT (33000 μg min−1) produced dose-dependent decreases, not increases, in external carotid blood flow and failed to antagonize (mean dose of 200±33 μg kg−1, i.c.) the agonist-induced vasodilator responses.The external carotid vasodilator responses to 5-HT, 5-CT and 5-methoxytryptamine were not modified by intravenous (i.v.) pretreatment with either saline, (±)-pindolol (4 mg kg−1) or ritanserin (100 μg kg−1) plus granisetron (300 μg kg−1), but were dose-dependently blocked by i.v. administration of methiothepin (10 and 30 μg kg−1, given after ritanserin plus granisetron), mesulergine (10 and 30 μg kg−1), metergoline (1 and 3 mg kg−1), methysergide (1 and 3 mg kg−1) or clozapine (0.3 and 1 mg kg−1). Nevertheless, the blockade of the above responses, not significant after treatment with the lower of the two doses of metergoline and mesulergine, was nonspecific after administration of the higher of the two doses of methysergide and clozapine.Based upon the above rank order of agonist potencies and the antagonism produced by a series of drugs showing high affinity for the cloned 5-ht7 receptor, our results indicate that the 5-HT receptor mediating external carotid vasodilatation in GR 127935-pretreated vagosympathectomized dogs is operationally similar to the putative 5-HT7 receptor mediating relaxation of vascular and non-vascular smooth muscles (e.g. rabbit femoral vein, canine coronary artery, rat systemic vasculature and guinea-pig ileum) as well as tachycardia in the cat. PMID:9105708

  3. 75 FR 69468 - Metlife Moosic, PA, Metlife Clarks Summit, PA; Notice of Affirmative Determination Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Metlife Moosic, PA, Metlife Clarks Summit, PA; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated August 2, 2010, the...

  4. 32 CFR 701.123 - PA fees.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... duplication for free. (1) DON activities shall waive fees automatically if the direct cost for reproduction of... made on a case-to-case basis. (c) PA fee deposits. Checks or money orders shall be made payable to...

  5. 78 FR 45282 - Pennsylvania Disaster #PA-00058

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00058 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... determined to be adversely affected by the disaster: Primary Counties: Clearfield; Fayette;...

  6. Multiple Option Grade Contracts.

    ERIC Educational Resources Information Center

    Partin, Ronald L.

    1979-01-01

    A flexible, point contract system is described which maximizes the advantages of a criterion-referenced contract system while eliminating some of the disadvantages of standard grade contracts. This model has been used by the author in a variety of high school and college courses. (Author/SJL)

  7. Teaching about Contracts.

    ERIC Educational Resources Information Center

    Froman, Michael; Kosnoff, Kathy

    1978-01-01

    Presents teaching strategies for introducing high school students to contract law. Offers as a case study a contract agreement between pro football players and team owners. Stresses basic elements of contracts (offer, acceptance, consideration, and understanding the bargaining process). Journal available from the American Bar Association, 1155…

  8. Oxidation of gas-phase protactinium ions, Pa+ and Pa2+: formation and properties of PaO2(2+)(g), protactinyl.

    PubMed

    Santos, Marta; de Matos, António Pires; Marçalo, Joaquim; Gibson, John K; Haire, Richard G; Tyagi, Rajni; Pitzer, Russell M

    2006-05-04

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N(2)O to the relatively weak CH(2)O-all oxidized Pa(+) to PaO(+) and PaO(+) to PaO(2)(+). On the basis of experimental observations, it was established that D[Pa(+)-O] and D[OPa(+)-O] > or = 751 kJ mol(-1). Estimates for D[Pa(+)-O], D[OPa(+)-O], IE[PaO], and IE[PaO(2)] were also obtained. The seven oxidants reacted with Pa(2+) to produce PaO(2+), indicating that D[Pa(2+)-O] > or = 751 kJ mol(-1). A particularly notable finding was the oxidation of PaO(2+) by N(2)O to PaO(2)(2+), a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO(2)(2+) suggested the protactinyl connectivity, {O-Pa-O}(2+). The experimentally determined IE[PaO(2)(+)] approximately 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO(2)(+) and PaO(2)(2+). These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial "6p hole" in the case of protactinyl. It was found that PaO(2)(2+) catalyzes the oxidation of CO by N(2)O-such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO(2)(2+) is capable of activating H(2) to form the stable PaO(2)H(2+) ion.

  9. Functional Characterization of Phalaenopsis aphrodite Flowering Genes PaFT1 and PaFD.

    PubMed

    Jang, Seonghoe; Choi, Sang-Chul; Li, Hsing-Yi; An, Gynheung; Schmelzer, Elmon

    2015-01-01

    We show that the key flowering regulators encoded by Phalaenopsis aphrodite FLOWERING LOCUS T1 (PaFT1) and PaFD share high sequence homologies to these from long-day flowering Arabidopsis and short-day flowering rice. Interestingly, PaFT1 is specifically up-regulated during flowering inductive cooling treatment but is not subjected to control by photoperiod in P. aphrodite. Phloem or shoot apex-specific expression of PaFT1 restores the late flowering of Arabidopsis ft mutants. Moreover, PaFT1 can suppress the delayed flowering caused by SHORT VEGATATIVE PHASE (SVP) overexpression as well as an active FRIGIDA (FRI) allele, indicating the functional conservation of flowering regulatory circuit in different plant species. PaFT1 promoter:GUS in Arabidopsis showed similar staining pattern to that of Arabidopsis FT in the leaves and guard cells but different in the shoot apex. A genomic clone or heat shock-inducible expression of PaFT1 is sufficient to the partial complementation of the ft mutants. Remarkably, ectopic PaFT1 expression also triggers precocious heading in rice. To further demonstrate the functional conservation of the flowering regulators, we show that PaFD, a bZIP transcription factor involved in flowering promotion, interacts with PaFT1, and PaFD partially complemented Arabidopsis fd mutants. Transgenic rice expressing PaFD also flowered early with increased expression of rice homologues of APETALA1 (AP1). Consistently, PaFT1 knock-down Phalaenopsis plants generated by virus-induced gene silencing exhibit delayed spiking. These studies suggest functional conservation of FT and FD genes, which may have evolved and integrated into distinct regulatory circuits in monopodial orchids, Arabidopsis and rice that promote flowering under their own inductive conditions.

  10. Functional Characterization of Phalaenopsis aphrodite Flowering Genes PaFT1 and PaFD

    PubMed Central

    Jang, Seonghoe; Choi, Sang-Chul; Li, Hsing-Yi; An, Gynheung; Schmelzer, Elmon

    2015-01-01

    We show that the key flowering regulators encoded by Phalaenopsis aphrodite FLOWERING LOCUS T1 (PaFT1) and PaFD share high sequence homologies to these from long-day flowering Arabidopsis and short-day flowering rice. Interestingly, PaFT1 is specifically up-regulated during flowering inductive cooling treatment but is not subjected to control by photoperiod in P. aphrodite. Phloem or shoot apex-specific expression of PaFT1 restores the late flowering of Arabidopsis ft mutants. Moreover, PaFT1 can suppress the delayed flowering caused by SHORT VEGATATIVE PHASE (SVP) overexpression as well as an active FRIGIDA (FRI) allele, indicating the functional conservation of flowering regulatory circuit in different plant species. PaFT1 promoter:GUS in Arabidopsis showed similar staining pattern to that of Arabidopsis FT in the leaves and guard cells but different in the shoot apex. A genomic clone or heat shock-inducible expression of PaFT1 is sufficient to the partial complementation of the ft mutants. Remarkably, ectopic PaFT1 expression also triggers precocious heading in rice. To further demonstrate the functional conservation of the flowering regulators, we show that PaFD, a bZIP transcription factor involved in flowering promotion, interacts with PaFT1, and PaFD partially complemented Arabidopsis fd mutants. Transgenic rice expressing PaFD also flowered early with increased expression of rice homologues of APETALA1 (AP1). Consistently, PaFT1 knock-down Phalaenopsis plants generated by virus-induced gene silencing exhibit delayed spiking. These studies suggest functional conservation of FT and FD genes, which may have evolved and integrated into distinct regulatory circuits in monopodial orchids, Arabidopsis and rice that promote flowering under their own inductive conditions. PMID:26317412

  11. 231Pa and 233Pa Neutron-Induced Fission Data Analysis

    SciTech Connect

    Maslov, V.M.; Tetereva, N.A.; Baba, M.; Hasegawa, A.; Kornilov, N.V.; Kagalenko, A.B.

    2005-05-24

    The 231Pa and 233Pa neutron-induced fission cross-section database is analyzed within the Hauser-Feshbach approach. The consistency of neutron-induced fission cross-section data and data extracted from transfer reactions is investigated. The fission probabilities of Pa, fissioning in 231,233Pa(n,nf) reactions, are defined by fitting (3He,d) or (3He,t) transfer-reaction data. The present estimate of the 233Pa(n,f) fission cross section above the emissive fission threshold is supported by smooth level-density parameter systematics, validated in the case of the 231Pa(n,f) data description up to En =20 MeV.

  12. 32 CFR 701.113 - PA exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.113 PA exemptions. (a) Exempt systems of records. 5 U.S.C. 552a authorizes SECNAV to adopt rules designating eligible systems of records as exempt from... responsible for proposing an exemption rule. Exempt systems of records are identified at...

  13. 32 CFR 701.113 - PA exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.113 PA exemptions. (a) Exempt systems of records. 5 U.S.C. 552a authorizes SECNAV to adopt rules designating eligible systems of records as exempt from... responsible for proposing an exemption rule. Exempt systems of records are identified at...

  14. 32 CFR 701.113 - PA exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.113 PA exemptions. (a) Exempt systems of records. 5 U.S.C. 552a authorizes SECNAV to adopt rules designating eligible systems of records as exempt from... responsible for proposing an exemption rule. Exempt systems of records are identified at...

  15. 76 FR 5647 - Pennsylvania Disaster #PA-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-01

    ... ADMINISTRATION Pennsylvania Disaster PA-00036 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 01/25/2011. Incident: Apartment Building Fire. Incident Period: 01/10/2011. Effective Date:...

  16. 77 FR 65044 - Pennsylvania Disaster #PA-00054

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... ADMINISTRATION Pennsylvania Disaster PA-00054 AGENCY: U.S. Small Business Administration. ACTION: Notice SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 10/18/2012. Incident: Cheltenham Township Condominium Complex Fire. Incident Period:...

  17. 75 FR 2165 - Pennsylvania Disaster #PA-00030

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... ADMINISTRATION Pennsylvania Disaster PA-00030 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 01/07/2010. Incident: Bellefonte Borough Apartment Complex Fire. Incident Period:...

  18. 77 FR 60004 - Pennsylvania Disaster #PA-00053

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... ADMINISTRATION Pennsylvania Disaster PA-00053 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 09/21/2012. Incident: Apartment Building Fire in Bellefonte Borough. Incident Period:...

  19. 78 FR 60366 - Pennsylvania Disaster #PA-00064

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00064 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... Application Deadline Date: 06/24/2014. ADDRESSES: Submit completed loan applications to: U.S. Small...

  20. 78 FR 4967 - Pennsylvania Disaster #PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00057 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... locations. The following areas have been determined to be adversely affected by the disaster:...

  1. Issues in physician contracting.

    PubMed

    Fanburg, John D; Leone, Alyson M

    2005-09-01

    Dermatologists will enter into a number of different contracts during their professional careers. It is important that in each agreement they enter, dermatologists reap the benefits that they aspire for and understand the consequences of each provision. This article addresses just a few of the different issues that arise in physician contracting, such as choosing the appropriate form of business entity; the importance of a writing; term and termination of the contract; compensation models; benefits, vacation and other time off included in the contract; malpractice insurance; and restrictive covenants. Each provision should be carefully analyzed to ensure that it will protect the best interests of the dermatologist in that situation.

  2. Effect of PaCO2 and PaO2 on lidocaine and articaine toxicity.

    PubMed

    Barcelos, K C; Furtado, D P; Ramacciato, J C; Cabral, A M; Haas, D A

    2010-01-01

    Alterations in arterial PaCO₂ can influence local anesthetic toxicity. The objective of this study was to evaluate the effect of stress-induced changes in PaCO₂ and PaO₂ on the seizure threshold of lidocaine and articaine. Lidocaine (2% with 1 : 100,000 epinephrine) or articaine (4% with 1 : 100,000 epinephrine) was administered intravenously under rest or stress conditions to 36 rats separated into 4 groups. Propranolol and prazosin were administered preoperatively to minimize cardiovascular effects of epinephrine. Mean arterial pressure (MAP), heart rate (HR), and arterial pH, PaCO₂, and PaO₂ were measured. Results showed no differences in MAP, HR, or pH. Stress significantly increased the latency period for the first tonic-clonic seizure induced by a toxic dose of both lidocaine and articaine (P < .05). Seizures were brought on more rapidly by articaine. No significant difference between toxic doses of lidocaine and articaine was noted. Stress raised the seizure threshold dose for both drugs and significantly (P < .01) increased arterial PaO₂ from 94.0 ± 1.90 mm Hg to 113.0 ± 2.20 mm Hg, and reduced PaCO₂ from 36.0 ± 0.77 mm Hg to 27.0 ± 0.98 mm Hg. In conclusion, reduction in PaCO₂ and/or increase in PaO₂ raised the seizure threshold of lidocaine and articaine. This study also confirmed that lidocaine and articaine have equipotent central nervous system toxicity.

  3. Effect of PaCO2 and PaO2 on Lidocaine and Articaine Toxicity

    PubMed Central

    Barcelos, K.C; Furtado, D.P; Ramacciato, J.C; Cabral, A.M; Haas, D.A

    2010-01-01

    Alterations in arterial PaCO2 can influence local anesthetic toxicity. The objective of this study was to evaluate the effect of stress-induced changes in PaCO2 and PaO2 on the seizure threshold of lidocaine and articaine. Lidocaine (2% with 1 ∶ 100,000 epinephrine) or articaine (4% with 1 ∶ 100,000 epinephrine) was administered intravenously under rest or stress conditions to 36 rats separated into 4 groups. Propranolol and prazosin were administered preoperatively to minimize cardiovascular effects of epinephrine. Mean arterial pressure (MAP), heart rate (HR), and arterial pH, PaCO2, and PaO2 were measured. Results showed no differences in MAP, HR, or pH. Stress significantly increased the latency period for the first tonic-clonic seizure induced by a toxic dose of both lidocaine and articaine (P < .05). Seizures were brought on more rapidly by articaine. No significant difference between toxic doses of lidocaine and articaine was noted. Stress raised the seizure threshold dose for both drugs and significantly (P < .01) increased arterial PaO2 from 94.0 ± 1.90 mm Hg to 113.0 ± 2.20 mm Hg, and reduced PaCO2 from 36.0 ± 0.77 mm Hg to 27.0 ± 0.98 mm Hg. In conclusion, reduction in PaCO2 and/or increase in PaO2 raised the seizure threshold of lidocaine and articaine. This study also confirmed that lidocaine and articaine have equipotent central nervous system toxicity. PMID:20843225

  4. Tying the Contract Knot.

    ERIC Educational Resources Information Center

    Reeves, Kimberly

    2001-01-01

    An informal survey of state superintendent associations and lawyers representing superintendents reveals little change in top executives' contracts over the past decade. Mandatory evaluations and renewable (non-"evergreen") contracts are becoming common; pay-for-performance measures are emerging, yet limited. Contractual and job-leaving…

  5. Contract Teachers in India

    ERIC Educational Resources Information Center

    Goyal, Sangeeta; Pandey, Priyanka

    2013-01-01

    In this paper, we use non-experimental data from government schools in Uttar Pradesh and Madhya Pradesh, two of the largest Indian states, to present average school outcomes by contract status of teachers. We find that contract teachers are associated with higher effort than civil service teachers with permanent tenures, before as well as after…

  6. The New Employment Contract?

    ERIC Educational Resources Information Center

    Levine, David I.

    2002-01-01

    In the classic employment contract, especially at large companies, wages were not strongly responsive to the labor market. Instead, individual companies had distinctive company wage levels and patterns. An exhaustive study of employers and employees in the United States and Japan examined whether the "old employment contract" has been…

  7. Weighing the Contract Option.

    ERIC Educational Resources Information Center

    Dervarics, Charles

    1993-01-01

    Contracting for noneducational services is standard operating procedure in many school districts. Private contractors are involved in transportation, food service, maintenance, and even, in rare cases, instruction. Before deciding to contract out, school boards should examine improvement to school-run operations before making a final decision.…

  8. Technical Insights for Saltstone PA Maintenance

    SciTech Connect

    Flach, G.; Sarkar, S.; Mahadevan, S.; Kosson, D.

    2011-07-20

    The Cementitious Barriers Partnership (CBP) is a collaborative program sponsored by the US DOE Office of Waste Processing. The objective of the CBP is to develop a set of computational tools to improve understanding and prediction of the long-term structural, hydraulic, and chemical performance of cementitious barriers and waste forms used in nuclear applications. CBP tools are expected to better characterize and reduce the uncertainties of current methodologies for assessing cementitious barrier performance and increase the consistency and transparency of the assessment process, as the five-year program progresses. In September 2009, entering its second year of funded effort, the CBP sought opportunities to provide near-term tangible support to DOE Performance Assessments (PAs). The Savannah River Saltstone Disposal Facility (SDF) was selected for the initial PA support effort because (1) cementitious waste forms and barriers play a prominent role in the performance of the facility, (2) certain important long-term behaviors of cementitious materials composing the facility are uncertain, (3) review of the SDF PA by external stakeholders is ongoing, and (4) the DOE contractor responsible for the SDF PA is open to receiving technical assistance from the CBP. A review of the current (SRR Closure & Waste Disposal Authority 2009) and prior Saltstone PAs (e.g., Cook et al. 2005) suggested five potential opportunities for improving predictions. The candidate topics considered were (1) concrete degradation from external sulfate attack, (2) impact of atmospheric exposure to concrete and grout before closure, such as accelerated slag and Tc-99 oxidation, (3) mechanistic prediction of geochemical conditions, (4) concrete degradation from rebar corrosion due to carbonation, and (5) early age cracking from drying and/or thermal shrinkage. The candidate topics were down-selected considering the feasibility of addressing each issue within approximately six months, and

  9. Structure investigations of PP-PA blends

    NASA Astrophysics Data System (ADS)

    Janicki, Jaroslaw; Wlochowicz, Andrzej; Slusarczyk, Czeslaw

    1997-02-01

    In the paper we have used the SAXS method in order to determine the supermolecular structure parameters, including the transition layer thickness, of polypropylene/polyamide-6 (PP/PA) blends. The transition layer thickness has been obtained by means of two methods elaborated by Koberstein and co-workers and by Ruland, respectively. Both these methods assume that changes of the electron density in the transition region can be described by a Gaussian function with a standard deviation (sigma) . The parameter (sigma) have been determined graphically from the appropriate plots. Then, the thickness of the phase boundary E was estimated as (root)12(sigma) . The investigated PP/PA blends are multiphase systems and the problem of determination of the boundary width is more complicated because the meaning of Porod's law must be considered with caution. This problem is discussed based on wide range of the investigated samples prepared over various pressure and crystallization temperature conditions.

  10. Fluoranthene degradation in Pseudomonas alcaligenes PA-10.

    PubMed

    Gordon, L; Dobson, A D

    2001-01-01

    Pseudomonas alcaligenes strain PA-10 degrades the four-ring polycyclic aromatic hydrocarbon fluoranthene, co-metabolically. HPLC analysis of the growth medium identified four intermediates, 9-fluorenone-1-carboxylic acid; 9-hydroxy-1-fluorene carboxylic acid; 9-fluorenone and 9-fluorenol, formed during fluoranthene degradation. Pre-exposure of PA-10 to 9-fluorenone-1-carboxylic acid and 9-hydroxy-1-fluorene-carboxylic acid resulted in increases in fluoranthene removal, while pre-exposure to 9-fluorenone and 9-fluorenol resulted in a decrease in fluoranthene degradation. The rate of indole transformation was similarly affected by pre-exposure to these metabolic intermediates, indicating a link between fluoranthene degradation and indigo formation in this strain.

  11. {sup 231}Pa photofission cross section

    SciTech Connect

    Soldatov, A.S.; Rudnikov, V.E.; Smirenkin, G.N.

    1995-12-01

    The measurements of the {sup 231}Pa yield and cross section photofission in the energy range 7-9 MeV are presented. These measurements are a continuation of similar measurements performed for the {gamma}-ray energy range 4.8-7 MeV. The entire collection of experimental data which combine the results obtained in the present work and in Ref. 1 was analyzed.

  12. Graphs for Isotopes of 91-Pa (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides a graphic representation of nucleon separation energies and residual interaction parameters for isotopes of the chemical element 91-Pa (Protactinium, atomic number Z = 91).

  13. Managing the Contract Closeout Process

    DTIC Science & Technology

    1992-03-01

    also fulfilled its obligations (Ref. l:p. 267]. The closeout process completes all the individual actions started during earlier segments of the...taught as a segment in the Management of Defense Acquisition Contracts (MDAC) Advanced Contract Administration course. There is no separate course for... segment ir the Management of Defense Acquisiticn Contracts (MDAC) Advanced Contract Administration course. The National Contract Management Association

  14. Fidelity to Theory in PA Intervention Research.

    PubMed

    Keller, Colleen; Fleury, Julie; Sidani, Souraya; Ainsworth, Barbara

    2009-04-01

    Research using theory-based interventions to promote regular physical activity (PA) has increased substantially over the past decade. The purpose of this article is to provide a review and summary of PA intervention research specific to fidelity to intervention theory, providing an overview of the concept of fidelity to intervention theory, defining the evaluative components of fidelity: (a) conceptualization of the problem, (b) operationalization of the theory, (c) specification of mediating processes, and (d) specification of outcome variables. Using journal scans and computerized literature database searches, the authors identified 470 PA activity intervention studies that incorporated a theoretical perspective. A validity framework explicated by was used to summarize intervention research in light of fidelity to intervention theory. In all, 15 intervention studies met the inclusion criteria and were incorporated into the review. Theoretical models for health behavior change, including social cognitive theory (SCT), cognitive behavioral theory (CBT), the transtheoretical model (TTM, the TTM combined with SCT), the reversal theory (theory of psychological reversals), and the disconnected values theory, were used as a basis for intervention design and evaluation.

  15. Sensor Kinase PA4398 Modulates Swarming Motility and Biofilm Formation in Pseudomonas aeruginosa PA14

    PubMed Central

    Strehmel, Janine; Neidig, Anke; Nusser, Michael; Geffers, Robert; Brenner-Weiss, Gerald

    2014-01-01

    Pseudomonas aeruginosa is an opportunistic human pathogen that is able to sense and adapt to numerous environmental stimuli by the use of transcriptional regulators, including two-component regulatory systems. In this study, we demonstrate that the sensor kinase PA4398 is involved in the regulation of swarming motility and biofilm formation in P. aeruginosa PA14. A PA4398− mutant strain was considerably impaired in swarming motility, while biofilm formation was increased by approximately 2-fold. The PA4398− mutant showed no changes in growth rate, rhamnolipid synthesis, or the production of the Pel exopolysaccharide but exhibited levels of the intracellular second messenger cyclic dimeric GMP (c-di-GMP) 50% higher than those in wild-type cells. The role of PA4398 in gene regulation was investigated by comparing the PA4398− mutant to the wild-type strain by using microarray analysis, which demonstrated that 64 genes were up- or downregulated more than 1.5-fold (P < 0.05) under swarming conditions. In addition, more-sensitive real-time PCR studies were performed on genes known to be involved in c-di-GMP metabolism. Among the dysregulated genes were several involved in the synthesis and degradation of c-di-GMP or in the biosynthesis, transport, or function of the iron-scavenging siderophores pyoverdine and pyochelin, in agreement with the swarming phenotype observed. By analyzing additional mutants of selected pyoverdine- and pyochelin-related genes, we were able to show that not only pvdQ but also pvdR, fptA, pchA, pchD, and pchH are essential for the normal swarming behavior of P. aeruginosa PA14 and may also contribute to the swarming-deficient phenotype of the PA4398− mutant in addition to elevated c-di-GMP levels. PMID:25501476

  16. Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility.

    PubMed

    Huang, Lin; Haratake, Kousuke; Miyahara, Hatsumi; Chiba, Tomoki

    2016-03-22

    Protein degradation mediated by the proteasome is important for the protein homeostasis. Various proteasome activators, such as PA28 and PA200, regulate the proteasome function. Here we show double knockout (dKO) mice of Psme3 and Psme4 (genes for PA28γ and PA200), but not each single knockout mice, are completely infertile in male. The dKO sperms exhibited remarkable defects in motility, although most of them showed normal appearance in morphology. The proteasome activity of the mutant sperms decreased notably, and the sperms were strongly positive with ubiquitin staining. Quantitative analyses of proteins expressed in dKO sperms revealed up-regulation of several proteins involved in oxidative stress response. Furthermore, increased 8-OHdG staining was observed in dKO sperms head, suggesting defective response to oxidative damage. This report verified PA28γ and PA200 play indispensable roles in male fertility, and provides a novel insight into the role of proteasome activators in antioxidant response.

  17. Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility

    PubMed Central

    Huang, Lin; Haratake, Kousuke; Miyahara, Hatsumi; Chiba, Tomoki

    2016-01-01

    Protein degradation mediated by the proteasome is important for the protein homeostasis. Various proteasome activators, such as PA28 and PA200, regulate the proteasome function. Here we show double knockout (dKO) mice of Psme3 and Psme4 (genes for PA28γ and PA200), but not each single knockout mice, are completely infertile in male. The dKO sperms exhibited remarkable defects in motility, although most of them showed normal appearance in morphology. The proteasome activity of the mutant sperms decreased notably, and the sperms were strongly positive with ubiquitin staining. Quantitative analyses of proteins expressed in dKO sperms revealed up-regulation of several proteins involved in oxidative stress response. Furthermore, increased 8-OHdG staining was observed in dKO sperms head, suggesting defective response to oxidative damage. This report verified PA28γ and PA200 play indispensable roles in male fertility, and provides a novel insight into the role of proteasome activators in antioxidant response. PMID:27003159

  18. 48 CFR 3042.7000 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SECURITY ACQUISITION REGULATION (HSAR) CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Contracting Officer's Technical Representative 3042.7000 Contract clause. The contracting officer shall insert the clause at (HSAR) 48 CFR 3052.242-72, Contracting Officer's Technical Representative,...

  19. AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels

    SciTech Connect

    Barrett, R.J.; Appell, K.C.; Kilpatrick, B.F.; Proakis, A.G.; Nolan, J.C.; Walsh, D.A. )

    1991-01-01

    In vivo and in vitro methods were used to characterize AHR-16303B, a novel compound with antagonistic action at 5-HT2 receptors and voltage-sensitive calcium channels. The 5-HT2 receptor-antagonistic properties of AHR-16303B were demonstrated by inhibition of (a) (3H)ketanserin binding to rat cerebral cortical membranes (IC50 = 165 nM); (b) 5-hydroxytryptamine (5-HT)-induced foot edema in rats (minimum effective dose, (MED) = 0.32 mg/kg orally, p.o.); (c) 5-HT-induced vasopressor responses in spontaneously hypertensive rats (SHR) (ID50 = 0.18 mg/kg intravenously (i.v.), 1.8 mg/kg p.o.), (d) 5-HT-induced antidiuresis in rats (MED = 1 mg/kg p.o.), and (e) platelet aggregation induced by 5-HT + ADP (IC50 = 1.5 mM). The calcium antagonist properties of AHR-16303B were demonstrated by inhibition of (a) (3H)nimodipine binding to voltage-sensitive calcium channels on rabbit skeletal muscle membranes (IC50 = 15 nM), (b) KCl-stimulated calcium flux into cultured PC12 cells (IC50 = 81 nM), and (c) CaCl2-induced contractions of rabbit thoracic aortic strips (pA2 = 8.84). AHR-16303B had little or no effect on binding of radioligands to dopamine2 (DA2) alpha 1, alpha 2, H1, 5-HT1 alpha, beta 2, muscarinic M1, or sigma opioid receptors; had no effect on 5-HT3 receptor-mediated vagal bradycardia; and had only minor negative inotropic, chronotropic, and dromotropic effects on isolated guinea pig atria. In conscious SHR, 30 mg/kg p.o. AHR-16303B completely prevented the vasopressor responses to i.v. 5-HT, and decreased blood pressure (BP) by 24% 3 h after dosing.

  20. Marine Corps Contingency Contracting MCI

    DTIC Science & Technology

    2003-12-01

    unfamiliar, such as, foreign business practices, cultures, and language barriers . The importance of having a trained contingency contracting officer...practices, cultures, and language barriers . D. WHO PERFORMS CONTINGENCY CONTRACTING The individuals who perform contingency contracting within the

  1. 5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression

    PubMed Central

    Verheggen, R; Hundeshagen, A G; Brown, A M; Schindler, M; Kaumann, A J

    1998-01-01

    In the human temporal artery both 5-HT1-like and 5-HT2A receptors mediate the contractile effects of 5-hydroxytryptamine (5-HT) and we have suggested that the 5-HT1-like receptors resemble more closely recombinant 5-HT1B than 5-HT1D receptors. To investigate further which subtype is involved, we investigated the blockade of 5-HT-induced contractions by the 5-HT1B-selective antagonist SB-224289 (2,3,6,7-tetrahydro-1′-methyl-5-{2-methyl-4′[(5-methyl-1,2,4-oxadiazole-3-yl) biphenyl-4-yl] carbonyl} furo[2,3-f]indole-3-spiro-4′-piperidine oxalate) and the 5-HT1D-selective antagonist BRL-15572 (1-phenyl-3[4-3-chlorophenyl piperazin-1-yl] phenylpropan-2-ol). We also used RT-PCR to search for the mRNA of 5-HT1B, 5-HT1D and other 5-HT receptors.The contractile effects of 5-HT in temporal artery rings were partially antagonized by SB-224289 (20, 200 nM) (apparent KB=1 nM) and ketanserin (1 μM) but not by BRL-15572 (500 nM).Sumatriptan evoked contractions (EC50, 170 nM) that were resistant to blockade by BRL-15572 (500 nM) but antagonized by SB-224289 (20, 200 nM).The potency of 5-HT (EC50) was estimated to be 94 nM for the ketanserin-sensitive receptor and 34 nM for the SB-224289-sensitive receptor. The fraction of maximal 5-HT response mediated through SB-224289-sensitive receptors was 0.20–0.67, the remainder being mediated through ketanserin-sensitive receptors.We detected arterial receptor mRNA for the following receptors (incidence): 5-HT1B (8/8), 5-HT1D (2/8), 5-HT1F (0/4), 5-HT2A (0/8), 5-HT2B (0/8), 5-HT2C (0/8), 5-HT4 (4/8) and 5-HT7 (4/8).We conclude that the ketanserin-resistant fraction of the 5-HT effects and the effects of sumatriptan are mediated by 5-HT1B receptors. The lack of antagonism by BRL-15572 rules out 5-HT1D receptors as mediators of the contractile effects of 5-HT and sumatriptan. PMID:9723944

  2. Drafting the Superintendent's Contract.

    ERIC Educational Resources Information Center

    Clark, James F.

    1983-01-01

    A superintendent's contract should be individually designed and negotiated; however, necessary characteristics are suggested in the areas of duration, certification and responsibilities, compensation, vacation and fringe benefits, liability and indemnification, medical examination, evaluation, renewal and nonrenewal, termination, and a…

  3. Negotiating managed care contracts.

    PubMed

    Beckman, P A; Fischer, T J

    1997-08-01

    Physicians currently have a major opportunity to help guide the rapid evolution of managed care in the United States. General principles on how physicians can successfully negotiate a managed care contract are discussed.

  4. Superfund Contract Laboratory Program

    EPA Pesticide Factsheets

    The Contract Laboratory Program (CLP) is a national network of EPA personnel, commercial laboratories, and support contractors whose primary mission is to provide data of known and documented quality to the Superfund program.

  5. Mechanics of Vorticella Contraction

    PubMed Central

    Misra, Gaurav; Dickinson, Richard B.; Ladd, Anthony J.C.

    2010-01-01

    Abstract Vorticella convallaria is one of a class of fast-moving organisms that can traverse its body size in less than a millisecond by rapidly coiling a slender stalk anchoring it to a nearby surface. The stalk houses a fiber called the spasmoneme, which winds helically within the stalk and rapidly contracts in response to calcium signaling. We have developed a coupled mechanical-chemical model of the coiling process, accounting for the coiling of the elastic stalk and the binding of calcium to the protein spasmin. Simulations of the model describe the contraction and recovery processes quantitatively. The stalk-spasmoneme system is shown to satisfy geometric constraints, which explains why the cell body sometimes rotates during contraction. The shape of the collapsing and recovering stalk bounds its effective bending stiffness. Simulations suggest that recovery from the contracted state is driven by the stalk at a rate controlled by dissociation of calcium from spasmin. PMID:20550905

  6. Mechanics of Vorticella contraction.

    PubMed

    Misra, Gaurav; Dickinson, Richard B; Ladd, Anthony J C

    2010-06-16

    Vorticella convallaria is one of a class of fast-moving organisms that can traverse its body size in less than a millisecond by rapidly coiling a slender stalk anchoring it to a nearby surface. The stalk houses a fiber called the spasmoneme, which winds helically within the stalk and rapidly contracts in response to calcium signaling. We have developed a coupled mechanical-chemical model of the coiling process, accounting for the coiling of the elastic stalk and the binding of calcium to the protein spasmin. Simulations of the model describe the contraction and recovery processes quantitatively. The stalk-spasmoneme system is shown to satisfy geometric constraints, which explains why the cell body sometimes rotates during contraction. The shape of the collapsing and recovering stalk bounds its effective bending stiffness. Simulations suggest that recovery from the contracted state is driven by the stalk at a rate controlled by dissociation of calcium from spasmin.

  7. Premature Ventricular Contractions (PVCs)

    MedlinePlus

    ... in the body that may be caused by caffeine, tobacco, exercise or anxiety Injury to the heart ... may increase your risk of premature ventricular contractions: Caffeine, tobacco and alcohol Exercise High blood pressure (hypertension) ...

  8. 3 CFR - Government Contracting

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... contract oversight could reduce such sums significantly. Government outsourcing for services also raises... governmental functions. Agencies and departments must operate under clear rules prescribing when outsourcing is... oversee acquisitions appropriately; and (4) clarify when governmental outsourcing for services is and...

  9. Advanced Contract Administration. First Week

    DTIC Science & Technology

    1988-04-14

    administration. Keywords: Contracting/administrative contracting officer relations Financial management; Production management , Quality assurance; Subcontracting; Claims; Government property; Ethics data sources and modifications.

  10. Joint Contingency Contracting

    DTIC Science & Technology

    2005-06-01

    Cdr (Head of Contracting Activity - HCA)FISC - Sigonella 5th Fleet AOR NAVSUP FISC Site - Dubai FISC Det-Bahrain Bahrain Seychelles CJOA Afghanistan...Services’ individual approaches for the accession of COs (and contracting specialists) is inconsistent and creates disparities between the breadth...and temperatures ranging from 130 degrees to below freezing. J42 AAdmin Clerk (Navy E-5) J4221 Fuels Ops Officer Navy

  11. AhV_aPA-induced vasoconstriction involves the IP₃Rs-mediated Ca²⁺ releasing.

    PubMed

    Zeng, Fuxing; Zou, Zhisong; Niu, Liwen; Li, Xu; Teng, Maikun

    2013-08-01

    AhV_aPA, the acidic PLA₂ purified from Agkistrodon halys pallas venom, was previously reported to possess a strong enzymatic activity and can remarkably induce a further contractile response on the 60 mM K⁺-induced contraction with an EC₅₀ in 369 nM on mouse thoracic aorta rings. In the present study, we found that the p-bromo-phenacyl-bromide (pBPB), which can completely inhibit the enzymatic activity of AhV_aPA, did not significantly reduce the contractile response on vessel rings induced by AhV_aPA, indicating that the vasoconstrictor effects of AhV_aPA are independent of the enzymatic activity. The inhibitor experiments showed that the contractile response induced by AhV_aPA is mainly attributed to the Ca²⁺ releasing from Ca²⁺ store, especially sarcoplasmic reticulum (SR). Detailed studies showed that the Ca²⁺ release from SR is related to the activation of inositol trisphosphate receptors (IP₃Rs) rather than ryanodine receptors (RyRs). Furthermore, the vasoconstrictor effect could be strongly reduced by pre-incubation with heparin, indicating that the basic amino acid residues on the surface of AhV_aPA may be involved in the interaction between AhV_aPA and the molecular receptors. These findings offer new insights into the functions of snake PLA₂ and provide a novel pathogenesis of A. halys pallas venom.

  12. Quantification of muscle co-contraction using supersonic shear wave imaging.

    PubMed

    Raiteri, Brent J; Hug, François; Cresswell, Andrew G; Lichtwark, Glen A

    2016-02-08

    Muscle stiffness estimated using shear wave elastography can provide an index of individual muscle force during isometric contraction and may therefore be a promising method for quantifying co-contraction. We estimated the shear modulus of the lateral gastrocnemius (LG) muscle using supersonic shear wave imaging and measured its myoelectrical activity using surface electromyography (sEMG) during graded isometric contractions of plantar flexion and dorsiflexion (n=7). During dorsiflexion, the average shear modulus was 26 ± 6 kPa at peak sEMG amplitude, which was significantly less (P=0.02) than that measured at the same sEMG level during plantar flexion (42 ± 10 kPa). The passive tension during contraction was estimated using the passive LG muscle shear modulus during a passive ankle rotation measured at an equivalent ankle angle to that measured during contraction. The passive shear modulus increased significantly (P<0.01) from the plantar flexed position (16 ± 5 kPa) to the dorsiflexed position (26 ± 9 kPa). Once this change in passive tension from joint rotation was accounted for, the average LG muscle shear modulus due to active contraction was significantly greater (P<0.01) during plantar flexion (26 ± 8 kPa) than at sEMG-matched levels of dorsiflexion (0 ± 4 kPa). The negligible shear modulus estimated during isometric dorsiflexion indicates negligible active force contribution by the LG muscle, despite measured sEMG activity of 19% of maximal voluntary plantar flexion contraction. This strongly suggests that the sEMG activity recorded from the LG muscle during isometric dorsiflexion was primarily due to cross-talk. However, it is clear that passive muscle tension changes can contribute to joint torque during isometric dorsiflexion.

  13. Apparatus to measure the vapor pressure of slowly decomposing compounds from 1 Pa to 105 Pa

    PubMed Central

    Berg, Robert F.

    2016-01-01

    This article describes an apparatus and method for measuring vapor pressures in the range from 1 Pa to 105 Pa. Its three distinctive elements are : (1) the static pressure measurements were made with only a small temperature difference between the vapor and the condensed phase, (2) the sample was degassed in situ, and (3) the temperature range extended up to 200 °C. The apparatus was designed to measure metal-organic precursors, which often are toxic, pyrophoric, or unstable. Vapor pressures are presented for naphthalene, ferrocene, diethyl phthalate, and TEMAH (tetrakisethylmethylaminohafnium). Also presented are data for the temperature-dependent decomposition rate of TEMAH. PMID:27274567

  14. Affine Contractions on the Plane

    ERIC Educational Resources Information Center

    Celik, D.; Ozdemir, Y.; Ureyen, M.

    2007-01-01

    Contractions play a considerable role in the theory of fractals. However, it is not easy to find contractions which are not similitudes. In this study, it is shown by counter examples that an affine transformation of the plane carrying a given triangle onto another triangle may not be a contraction even if it contracts edges, heights or medians.…

  15. Energetics of contraction.

    PubMed

    Barclay, C J

    2015-04-01

    Muscles convert energy from ATP into useful work, which can be used to move limbs and to transport ions across membranes. The energy not converted into work appears as heat. At the start of contraction heat is also produced when Ca(2+) binds to troponin-C and to parvalbumin. Muscles use ATP throughout an isometric contraction at a rate that depends on duration of stimulation, muscle type, temperature and muscle length. Between 30% and 40% of the ATP used during isometric contraction fuels the pumping Ca(2+) and Na(+) out of the myoplasm. When shortening, muscles produce less force than in an isometric contraction but use ATP at a higher rate and when lengthening force output is higher than the isometric force but rate of ATP splitting is lower. Efficiency quantifies the fraction of the energy provided by ATP that is converted into external work. Each ATP molecule provides 100 zJ of energy that can potentially be converted into work. The mechanics of the myosin cross-bridge are such that at most 50 zJ of work can be done in one ATP consuming cycle; that is, the maximum efficiency of a cross-bridge is ∼50%. Cross-bridges in tortoise muscle approach this limit, producing over 90% of the possible work per cycle. Other muscles are less efficient but contract more rapidly and produce more power.

  16. 5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.58. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  17. 6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  18. 4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.73 - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  19. 7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  20. Future Contracting for Availability

    DTIC Science & Technology

    2016-04-30

    qÜáêíÉÉåíÜ=^ååì~ä= ^Åèìáëáíáçå=oÉëÉ~êÅÜ= póãéçëáìã= qÜìêëÇ~ó=pÉëëáçåë= sçäìãÉ=ff= = Future Contracting for Availability Lou Kratz, Vice President and Managing ...Alpert, Analyst, Systecon North America Future Contracting for Availability Lou Kratz, Vice President and Managing Director, Logistics...êÉ~íáåÖ=póåÉêÖó=Ñçê=fåÑçêãÉÇ=`Ü~åÖÉ= - 18 - Future Contracting for Availability Lou Kratz—is the Vice President and Managing Director, Logistics

  1. 48 CFR 3416.701 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Agreements 3416.701 Contract clause. The contracting... organizations that have fixed indirect cost rates with carryforward adjustments approved by the Government agency responsible for negotiating the organization's indirect cost rates....

  2. 48 CFR 3017.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contracts. 3017.204 Section... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3017.204 Contracts....

  3. 48 CFR 3017.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Contracts. 3017.204... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options. 3017.204 Contracts....

  4. 48 CFR 3017.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contracts. 3017.204... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options. 3017.204 Contracts....

  5. 48 CFR 3017.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Contracts. 3017.204... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3017.204 Contracts....

  6. 48 CFR 3017.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Contracts. 3017.204... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3017.204 Contracts....

  7. Contracting with Teacher Partnerships.

    ERIC Educational Resources Information Center

    Shaten, Jessica; Kolderie, Ted

    This monograph describes the concept of school district contracts with teacher partnerships for educational services; taking the view of education as an industry, the document analyzes advantages, obstacles, and strategies of such a change. Section 1, "The Challenge," suggests that societal changes make an education industry outside the…

  8. Acting Out Muscle Contraction.

    ERIC Educational Resources Information Center

    Hudson, Margaret

    2003-01-01

    Describes a science activity that can be implemented into anatomy and physiology courses that demonstrates the interactions between action and myosin, the roles of sodium and calcium ions in the regulation of contraction, and the functions of the plasma membrane and the sarcoplasmic reticulum. (YDS)

  9. Model for Contingency Contracting.

    ERIC Educational Resources Information Center

    Prince George's Community Coll., Largo, MD. Dept. of Human Development.

    The Department of Human Development at Prince George's Community College has developed a contingency contracting model for the department's counseling and student services which presents planning and evaluation as interrelated parts of the same process of self-imposed accountability. The implementation of the model consisted of: (1) planning…

  10. Employee contract issues for dermatologists.

    PubMed

    Brown, Christopher E; Indest, George F

    2013-12-01

    Employees and employers routinely face negotiating and preparing physician employment contracts. It is important for both sides to know and understand the basic information on what a comprehensive employment contract for a dermatologist should contain. There are various employment contract provisions from both the employee's perspective and the employer's perspective that must be considered when preparing physician employment contracts. This article provides basic advice and recommendations on requirements that should be included in such contracts. It suggests legal pitfalls that can be avoided through various contract clauses.

  11. Contracting with the Enemy: The Contracting Officer’s Dilemma

    DTIC Science & Technology

    2015-06-01

    authority is the legal authority to enter into binding contracts and obligate funds on behalf of the U.S. Government (USG), while command authority includes...include authority to make binding contracts or modify existing contracts for the USG. It is also important to note that Geographical Combatant...Appointment, which provides the legal authorization to enter into binding contracts and obligate appropriated funds on behalf of the U.S. government

  12. Te mahi niho hauora ki Ratana Pa: the dental health project at Ratana Pa.

    PubMed

    Broughton, J

    1995-09-01

    Following the success of a dental health project provided for Maori communities along the Wanganui River by the Royal New Zealand Dental Corps, the people of Ratana Pa, 20 km south of Wanganui, requested a similar service. Funding for a pilot project was provided by the Central Regional Health Authority through Good Health Wanganui. The project was a joint venture between the Health Committee of Ratana Pa and Dental Health of Good Health Wanganui. The dental health of the people at Ratana Pa was generally poor, featuring a high rate of decay and serious periodontal disease. Severe halitosis was common. As a result of poor oral health, many patients, especially young women, were whakama, a state of embarrassment and shame that caused them to keep their teeth hidden. An increase in self-esteem and greater interest in dental health occurred after treatment. A second treatment phase began in March 1995. This community-driven Maori health initiative, in partnership with a Regional Health Authority, fulfils obligations under the Treaty of Waitangi.

  13. Mechanical Anisotropy of Rat Aortic Smooth Muscle Cells Decreases with Their Contraction

    NASA Astrophysics Data System (ADS)

    Nagayama, Kazuaki; Matsumoto, Takeo

    Tensile properties of smooth muscle cells freshly isolated from rat thoracic aortas (FSMCs) in their major and minor axes were measured using a laboratory-made micro tensile tester. The relationship between the tension applied to a cell and its elongation was obtained in untreated cells and those treated with 10-5M serotonin to induce contraction. An initial stiffness of untreated FSMCs, normalized by their initial cross-sectional area perpendicular to the stretch direction, was significantly higher in the major axis (14.8±4.3kPa, mean±SEM, n=5) than the minor axis (2.8±1.0kPa, n=5). The stiffness increased significantly in response to the contraction, but the increase was much higher in the minor axis (59.0±9.4kPa, n=4) than in the major (88.1±13.3kPa, n=4). The difference between the two directions was insignificant in the contracted state. Observations of the morphology of actin filaments with a confocal laser scanning microscope in untreated FSMCs revealed that they were long fibers running almost parallel to the major axis, while those in contracted cells showed an aggregated structure without a preferential direction. These results may indicate that anisotropy in untreated FSMCs is caused by the anisotropic alignment of their actin filaments, and that such anisotropy disappears in response to actin filament reorganization caused by the contraction.

  14. 48 CFR 3443.107 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clause. 3443.107... CONTRACT MANAGEMENT CONTRACT MODIFICATIONS General 3443.107 Contract clause. The contracting officer must... cost-reimbursement contracts in which it will be essential for the contracting officer to be...

  15. 48 CFR 3416.307 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clauses. 3416.307... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 3416.307 Contract clauses. (a) If the clause at FAR 52.216-7 (Allowable Cost and Payment) is used in a contract with...

  16. 48 CFR 3016.406 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clauses. 3016.406... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 3016.406 Contract clauses. (e)(1)(i) The contracting officer shall insert a clause substantially the...

  17. Utility Energy Services Contracts Guide

    SciTech Connect

    2013-09-01

    The UESC Guide is a compilation of samples and templates developed as a resource to help contracting officers implement task orders for UESCs under existing U.S. General Services Administration areawide contracts.

  18. Russian Contract Procurement Document

    SciTech Connect

    Tobin, J G

    2010-03-29

    This contract supports the enhancement of physical protection or nuclear material control and accounting systems at institutes or enterprises of the newly independent states under the material protection control and accounting (MPC&A) program. The contract is entered into pursuant to the MPC&A Program, a gratuitous technical assistance program, in accordance with the bilateral Agreements between the Russian Federation and the United States of America concerning the Safe and Secure Transportation, Storage and Destruction of Weapons and the Prevention of Weapons Proliferation of June 1992, as extended and amended by Protocol signed of June 1999, Agreement between the Government of the Russian Federation regarding Cooperation in the Area of Nuclear Materials Physical Protection, Control and Accounting of October 1999 and the Russian Federation law of May 1999 on the taxation exemption of gratuitous technical assistance with Russian Federation under registration No.DOE001000.

  19. Dupuytren's Contracture: Fibroblast Contraction?

    PubMed Central

    Gabbiani, Giulio; Majno, Guido

    1972-01-01

    In 6 cases of Dupuytren's disease and 1 of Ledderhose's disease, the nodules of the palmar and plantar aponeurosis were examined by light and electron microscopy. The cells composing these nodules, presumably fibroblasts, showed three significant ultrastructural features: (1) a fibrillar system similar to that of smooth muscle cells; (2) nuclear deformations such as are found in contracted cells, the severest being recognizable by light microscopy (cross-banded nuclei); (3) cell-to-cell and cell-to-stroma attachments. Based on these data and on recent information about the biology of the fibroblasts, it is suggested that these cells are fibroblasts that have modulated into contractile cells (myofibroblasts), and that their contraction plays a role in the pathogenesis of the contracture observed clinically. ImagesFig 10Fig 5Fig 11Fig 6 and 7Fig 8Fig 1Fig 2Fig 9Fig 3Fig 4 PMID:5009249

  20. Contracts for dispatchable power

    SciTech Connect

    Kahn, E.P.; Stoft, S.; Marnay, C.; Berman, D.

    1990-10-01

    Competitive bidding for electric power is maturing. Increasing numbers of utilities are soliciting proposals from private suppliers. The amount of capacity being sought is increasing, and potential suppliers appear to be abundant. Analysis of these developments still remains limited. Evidence on the behavior of this market is scarce and sketchy. The underlying economic principles that are shaping the market have not clearly been articulated. In this report we examine the economics of competitive bidding both empirically and analytically. Previous study of this market has focused on the evaluation criteria specified in Requests for Proposals (RFPs), and highly aggregated summary statistics on participation and results. We continue the examination of RFPs, but also survey the details of long term contracts that have emerged from competitive bidding. Contracts provide a new level of specific detail that has not been previously available. 68 refs., 13 figs., 25 tabs.

  1. The Value of Competitive Contracting

    DTIC Science & Technology

    2014-09-01

    Research & Engineering) BBP Better Buying Power BOA basic ordering agreement BPA basic purchase agreement CAE Component Acquisition Executive CDSA...Basic Ordering Agreement ( BOA ) c. Government wide acquisition contracts and IDIQ contracts d. BPAs and BPA calls under Federal Supply Schedules...contract actions ( BOAs , BPAs, FSS, and GWAC) contracts that are not required to report the number of competitive offers. The fiscal year 2011 DOD

  2. The Psychological Contract

    DTIC Science & Technology

    2009-10-01

    employee commitment • Freedom to sign new contracts • Little learning • Low integration/identification Transitional • Ambiguity/uncertainty • High...turnover • Instability T im ef ra m e Lo ng T er m Balanced • High employee commitment • High integration/identification • Mutual employee...organization support • Dynamic Relational • High employee commitment • High affective commitment • High integration/identification • Stability 14

  3. Army Contigency Contracting.

    DTIC Science & Technology

    1985-11-01

    r I I ;. - L U C A ,. . • - J 01 .1 .1 C.. - 0 . c s U- 101 1. L.J 1 L I.C w - L.. . 4-.- 22...and transportation services as well. The noble intentions of an occupying power would mean r little to a civilian population suffering from basic...PROPOSAL EVALUAT ION NEGOTIATION AWARD CONTRACT ADMINISTRATION * PERFORMANCE A r P C []"O’ PCD GOVERNMENT ACO CONTRACTOR EXPERIENCE COR EXPER I

  4. Construction Contract Provisions Analysis.

    DTIC Science & Technology

    1982-09-01

    bidding and contract docuents. These documents appear together in the bid package. After the bid, the IFB (or RFTP, RFP ) is extracted and the remainder...Corps personnel suggest that the original reason for the clause -- to prevent brokering - is anachronistic in the current construction market. However...amount of premiums paid for performance and payment * bonds (including coinsurance and reinsurance agreements, when applicable) after furnishing

  5. The Unwritten Contract

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Hosted by former STS-1 Astronaut Bob Crippen, this video highlights the Space Shuttle program team's commitment to quality assurance as being the unwritten contract all workers in the shuttle program have with the flight crews: To keep them and the whole Space Transportation System safe. The video is presented by the Marshall Space Flight Center's Safety, Reliability, Maintainability, and Quality Assurance Office (SRM&QA).

  6. Contracting As A Science

    DTIC Science & Technology

    2012-04-30

    disconfirmation of expectations theory to examine customer satisfaction in the procuring contracting officer ( PCO )–program manager (PM) relationship in...feedback to unsuccessful offerors reduces or eliminates feelings of inequity, a negotiated agreement is considered inequitable, company perception of...outcomes will be judged (Helson, 1964). Some of the areas to which researchers have applied adaptation- level theory include price perception and the

  7. Contracting as a Science

    DTIC Science & Technology

    2012-04-30

    disconfirmation of expectations theory to examine customer satisfaction in the procuring contracting officer ( PCO )–program manager (PM) relationship in...feedback to unsuccessful offerors reduces or eliminates feelings of inequity, a negotiated agreement is considered inequitable, company perception of...outcomes will be judged (Helson, 1964). Some of the areas to which researchers have applied adaptation- level theory include price perception and the

  8. Elements of gas contracts

    SciTech Connect

    O`Neal, J.

    1995-12-01

    The gas marketing scene has taken on a new look from the days of the {open_quotes}Long Term{close_quotes} or {open_quotes}Life of Lease{close_quotes} Contracts. In the past natural gas was of ten sold direct from the wellhead or a producer-owned facility to a pipeline company at a flat rate price and the only parties involved were producer or seller and buyer. Today, the parties involved in the marketing process might include a gathering entity to gather gas at a central point and provide gathering, compression and/or dehydration services; multiple pipeline companies for transportation; sales representatives or marketing brokers to negotiate a sale of the available gas on a monthly basis; and purchasers or end users. New terms have also been introduced in the process such as: {open_quotes}LDC{close_quotes} (local distribution company), {open_quotes}FERC Order 636{close_quotes}, {open_quotes}Price Delivered-to-Pipeline{close_quotes} and the various {open_quotes}levels of Service{close_quotes} under Gas Sales and Purchase Agreements. Four common levels of service are: {open_quotes}Firm{close_quotes}, {open_quotes}Baseload{close_quotes}, {open_quotes}Swing{close_quotes} and {open_quotes}Baseload/Operational{close_quotes}. It is evident that current marketing plans often require a separate contract for each service or commitment. Contract contents vary greatly, but most contain the following elements.

  9. Why radiologists lose their hospital contracts: is your contract secure?

    PubMed

    Muroff, Lawrence R

    2010-03-01

    Previously, a hospital contract meant tenure for the incumbent group of radiologists; however, those days are long gone. Exclusive contracts have morphed into exclusive contracts with carve-outs. Turf erosion has become a fact of life for radiology practices. Now radiologists are losing their hospital contracts in record numbers. Group size, though helpful for a variety of reasons, does not ensure that a practice will be secure in its hospital setting. The reasons that groups lose their hospital contracts are varied, and in this paper, the author discusses the most common ones. Suggestions to help practices avoid this unfortunate fate are presented.

  10. How Learning Contracts Motivate Students

    ERIC Educational Resources Information Center

    Greenwood, Scott C.; McCabe, Patrick P.

    2008-01-01

    In this article, the authors discuss how learning contracts can motivate students. "A learning contract is simply a written agreement between teacher and learner in which the learner undertakes to complete mutually agreed upon tasks in a specified amount of time on his or her own initiative" (Greenwood, 2003, p.1). Contracts are designed to…

  11. Health Contract in the Classroom

    ERIC Educational Resources Information Center

    Haber, David

    2007-01-01

    A health contract is a technique used by health professionals to help clients achieve a health goal. This article describes a course, "Changing Health Behaviors," in which a health contract strategy is taught and practiced with older adults. The health contract can also be included as a smaller educational component within a gerontology course…

  12. 48 CFR 2446.710 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 2446.710 Contract clauses. (c)(1) The contracting officer... Performance Specifications or Design Criteria, whenever it is in the Government's interest....

  13. 48 CFR 2446.710 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 2446.710 Contract clauses. (c)(1) The contracting officer... Performance Specifications or Design Criteria, whenever it is in the Government's interest....

  14. 48 CFR 2446.710 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 2446.710 Contract clauses. (c)(1) The contracting officer... Performance Specifications or Design Criteria, whenever it is in the Government's interest....

  15. Proteasome Activators, PA28α and PA28β, Govern Development of Microvascular Injury in Diabetic Nephropathy and Retinopathy

    PubMed Central

    Mahmoudpour, Ali

    2016-01-01

    Diabetic nephropathy (DN) and diabetic retinopathy (DR) are major complications of type 1 and type 2 diabetes. DN and DR are mainly caused by injury to the perivascular supporting cells, the mesangial cells within the glomerulus, and the pericytes in the retina. The genes and molecular mechanisms predisposing retinal and glomerular pericytes to diabetic injury are poorly characterized. In this study, the genetic deletion of proteasome activator genes, PA28α and PA28β genes, protected the diabetic mice in the experimental STZ-induced diabetes model against renal injury and retinal microvascular injury and prolonged their survival compared with wild type STZ diabetic mice. The improved wellbeing and reduced renal damage was associated with diminished expression of Osteopontin (OPN) and Monocyte Chemoattractant Protein-1 (MCP-1) in the glomeruli of STZ-injected PA28α/PA28β double knockout (Pa28αβDKO) mice and also in cultured mesangial cells and retinal pericytes isolated from Pa28αβDKO mice that were grown in high glucose. The mesangial PA28-mediated expression of OPN under high glucose conditions was suppressed by peptides capable of inhibiting the binding of PA28 to the 20S proteasome. Collectively, our findings demonstrate that diabetic hyperglycemia promotes PA28-mediated alteration of proteasome activity in vulnerable perivascular cells resulting in microvascular injury and development of DN and DR. PMID:27830089

  16. 48 CFR 2415.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING METHODS AND CONTRACTING TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 2415.204 Contract format. (e) The cognizant HCA shall be responsible for making...

  17. 48 CFR 39.107 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY General 39.107 Contract clause. The contracting officer..., in solicitations and contracts for information technology which require security of information... information technology services or support services....

  18. 48 CFR 2442.1107 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... information technology services. ... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Production Surveillance and Reporting 2442... clause at 2452.242-71, Contract Management System, in solicitations and contracts when all of...

  19. 48 CFR 3035.7000 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SECURITY ACQUISITION REGULATION (HSAR) SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Information Dissemination by Educational Institutions 3035.7000 Contract clause. The contracting officer may use the clause at (HSAR) 48 CFR 3052.235-70, Dissemination of...

  20. 48 CFR 15.204-1 - Uniform contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 15.204-1 Uniform contract format. (a) Contracting officers shall prepare solicitations...

  1. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  2. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  3. Genome Sequence of Pseudomonas chlororaphis Strain PA23

    PubMed Central

    Loewen, Peter C.; Villenueva, Jacylyn; Fernando, W. G. Dilantha

    2014-01-01

    Pseudomonas chlororaphis strain PA23 is a plant-beneficial bacterium that is able to suppress disease caused by the fungal pathogen Sclerotinia sclerotiorum through a process known as biological control. Here we present a 7.1-Mb assembly of the PA23 genome. PMID:25035328

  4. 78 FR 48297 - Amendment of Class E Airspace; Bedford, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Bedford, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E Airspace at... proposed rulemaking (NPRM) to amend Class E airspace at Bedford County Airport, Bedford, PA. (78 FR...

  5. TraceContract

    NASA Technical Reports Server (NTRS)

    Kavelund, Klaus; Barringer, Howard

    2012-01-01

    TraceContract is an API (Application Programming Interface) for trace analysis. A trace is a sequence of events, and can, for example, be generated by a running program, instrumented appropriately to generate events. An event can be any data object. An example of a trace is a log file containing events that a programmer has found important to record during a program execution. Trace - Contract takes as input such a trace together with a specification formulated using the API and reports on any violations of the specification, potentially calling code (reactions) to be executed when violations are detected. The software is developed as an internal DSL (Domain Specific Language) in the Scala programming language. Scala is a relatively new programming language that is specifically convenient for defining such internal DSLs due to a number of language characteristics. This includes Scala s elegant combination of object-oriented and functional programming, a succinct notation, and an advanced type system. The DSL offers a combination of data-parameterized state machines and temporal logic, which is novel. As an extension of Scala, it is a very expressive and convenient log file analysis framework.

  6. Which managed care contract(s) should you sign?

    PubMed

    Biddinger, D

    2001-01-01

    Contracts are a basic responsibility in running a medical practice--so much so that it's inappropriate to pass those responsibilities to someone else. Managers must at least understand the basic terms and conditions of the contract and the reimbursement their practices will receive. This article is written from the perspective of a privately owned medical practice and addresses only discounted, fee-for-service managed care contracts.

  7. 48 CFR 935.071 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 935.071... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.071 Contract clause. The contracting officer must insert the clause at 952.235-71, Research Misconduct, in contracts, including management and...

  8. 48 CFR 1316.406 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1316.406 Section 1316.406 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 1316.406 Contract clauses. Insert a...

  9. 48 CFR 937.7040 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 937.7040... CONTRACTING SERVICE CONTRACTING Protective Services Contracting 937.7040 Contract clauses. The contracting officer shall insert the clause at 952.237-70 entitled “Collective bargaining...

  10. 48 CFR 1517.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve a contract...

  11. 48 CFR 1846.470 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 1846.470 Contract clause. The contracting officer may insert a clause substantially as stated at 1852.246-71, Government Contract Quality Assurance Functions, in solicitations and contracts to specify the location(s) of quality...

  12. 48 CFR 316.307 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clauses. 316.307 Section 316.307 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-reimbursement Contracts 316.307 Contract clauses. (a) If a...

  13. 48 CFR 2442.1107 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... value of $500,000 or less. (d) The clause shall not be used in contracts for information technology... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production Surveillance and Reporting 2442.1107 Contract clause..., Contract Management System, in solicitations and contracts when all of the following conditions apply:...

  14. 48 CFR 2442.1107 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... value of $500,000 or less. (d) The clause shall not be used in contracts for information technology... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production Surveillance and Reporting 2442.1107 Contract clause..., Contract Management System, in solicitations and contracts when all of the following conditions apply:...

  15. 48 CFR 3416.307 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 3416.307 Contract... solicitations of and resultant cost-reimbursement contracts with nonprofit organizations other than educational institutional, hospitals, or organizations listed in Attachment C to Office of Management and Budget Circular...

  16. 48 CFR 3417.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Contracts. 3417.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3417.204 Contracts. (e) Except as otherwise provided by law, contract periods that exceed the five-year limitation specified in FAR...

  17. 48 CFR 716.406 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 716.406 Section 716.406 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost Reimbursement Contracts 716.406 Contract clauses....

  18. 48 CFR 2417.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contracts. 2417.204... CONTRACTING METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e) The Senior Procurement Executive shall approve any solicitation or contract which exceeds the five (5)...

  19. 48 CFR 4.103 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 4.103... MATTERS Contract Execution 4.103 Contract clause. The contracting officer shall insert the clause at 52.204-1, Approval of Contract, in solicitations and contracts if required by agency procedures....

  20. 48 CFR 3417.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Contracts. 3417.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3417.204 Contracts. (e) Except as otherwise provided by law, contract periods that exceed the five-year limitation specified in FAR...

  1. 48 CFR 3016.603 - Letter contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Letter contracts. 3016.603... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 3016.603 Letter contracts....

  2. 48 CFR 2017.204 - Contracts

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts 2017.204 Section 2017.204 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2017.204 Contracts (a) The contracting officer...

  3. 48 CFR 1817.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contracts. 1817.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option periods) applies to all NASA contracts regardless of type and...

  4. 48 CFR 916.307 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 916.307 Section 916.307 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 916.307 Contract clauses. (g) Insert...

  5. 48 CFR 817.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Contracts. 817.204 Section 817.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer...

  6. 48 CFR 1817.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contracts. 1817.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option periods) applies to all NASA contracts regardless of type and...

  7. 48 CFR 817.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contracts. 817.204 Section 817.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer...

  8. 48 CFR 1817.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contracts. 1817.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option periods) applies to all NASA contracts regardless of type and...

  9. 24 CFR 883.602 - The contract.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false The contract. 883.602 Section 883... Contract § 883.602 The contract. (a) Contract. The Housing Assistance Payments Contract sets forth rights... payments. (b) Housing Assistance Payments to Owners under the Contract. The Housing Assistance...

  10. 48 CFR 2017.204 - Contracts

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contracts 2017.204 Section 2017.204 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2017.204 Contracts (a) The contracting officer...

  11. 48 CFR 817.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Contracts. 817.204 Section 817.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer...

  12. 48 CFR 2017.204 - Contracts

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contracts 2017.204 Section 2017.204 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2017.204 Contracts (a) The contracting officer...

  13. 48 CFR 2417.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contracts. 2417.204... CONTRACTING METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e) The Senior Procurement Executive shall approve any solicitation or contract which exceeds the five (5)...

  14. 48 CFR 1817.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contracts. 1817.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option periods) applies to all NASA contracts regardless of type and...

  15. 48 CFR 2417.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contracts. 2417.204... CONTRACTING METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e)(1) The Senior Procurement Executive (SPE) is authorized to approve contract periods for other than...

  16. 48 CFR 3416.603 - Letter contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Letter contracts. 3416.603... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 3416.603 Letter contracts....

  17. 24 CFR 880.501 - The contract.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false The contract. 880.501 Section 880... Contract § 880.501 The contract. (a) Contract. The Housing Assistance Payments Contract sets forth rights and duties of the owner and the contract administrator with respect to the project and the...

  18. 48 CFR 16.302 - Cost contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Cost contracts. 16.302 Section 16.302 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.302 Cost contracts....

  19. 48 CFR 17.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Contracts. 17.204 Section 17.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify...

  20. 48 CFR 817.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracts. 817.204 Section 817.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer...

  1. 48 CFR 417.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Contracts. 417.204 Section 417.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting...

  2. 48 CFR 3042.7000 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clause. 3042.7000... SECURITY ACQUISITION REGULATION (HSAR) CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Contracting Officer's Technical Representative 3042.7000 Contract clause. The contracting officer shall...

  3. 48 CFR 3417.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contracts. 3417.204 Section... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3417.204 Contracts. (e) Except as otherwise provided by law, contract periods that exceed the five-year limitation specified in FAR...

  4. 48 CFR 16.307 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 16.307 Section 16.307 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.307 Contract clauses. (a)(1)...

  5. 48 CFR 17.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contracts. 17.204 Section 17.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify...

  6. 48 CFR 817.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contracts. 817.204 Section 817.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer...

  7. 48 CFR 716.406 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clauses. 716.406 Section 716.406 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost Reimbursement Contracts 716.406 Contract clauses....

  8. 48 CFR 3417.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Contracts. 3417.204... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 3417.204 Contracts. (e) Except as otherwise provided by law, contract periods that exceed the five-year limitation specified in FAR...

  9. 48 CFR 417.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracts. 417.204 Section 417.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting...

  10. 48 CFR 1416.405 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1416.405 Section 1416.405 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 1416.405 Contract clauses. The BPC, without the...

  11. 48 CFR 2417.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contracts. 2417.204... CONTRACTING METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e)(1) The Senior Procurement Executive (SPE) is authorized to approve contract periods for other than...

  12. 48 CFR 2017.204 - Contracts

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contracts 2017.204 Section 2017.204 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2017.204 Contracts (a) The contracting officer...

  13. 48 CFR 417.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Contracts. 417.204 Section 417.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting...

  14. 48 CFR 417.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contracts. 417.204 Section 417.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting...

  15. 48 CFR 16.406 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 16.406 Section 16.406 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 16.406 Contract clauses. (a) Insert...

  16. 48 CFR 732.111 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clauses. 732.111... CONTRACTING REQUIREMENTS CONTRACT FINANCING General 732.111 Contract clauses. (a) (b) USAID may obtain short... indefinite quantity contracts that are a combination of contract types. Rather than using the...

  17. 48 CFR 1817.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts. 1817.204 Section... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option periods) applies to all NASA contracts regardless of type and...

  18. 48 CFR 3417.70 - Modular contracting.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Modular contracting. 3417... REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Modular Contracting 3417.70 Modular contracting. (a) FSA—May incrementally conduct successive procurements of modules of...

  19. 48 CFR 417.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Contracts. 417.204 Section 417.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting...

  20. 48 CFR 17.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Contracts. 17.204 Section 17.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify...

  1. 48 CFR 17.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contracts. 17.204 Section 17.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify...

  2. 48 CFR 2017.204 - Contracts

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contracts 2017.204 Section 2017.204 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2017.204 Contracts (a) The contracting officer...

  3. 48 CFR 17.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contracts. 17.204 Section 17.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify...

  4. 24 CFR 881.501 - The contract.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false The contract. 881.501 Section 881... Payments Contract § 881.501 The contract. (a) Contract. The Housing Assistance Payments Contract sets forth rights and duties of the owner and the contract administrator with respect to the project and the...

  5. 48 CFR 732.111 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 732.111... CONTRACTING REQUIREMENTS CONTRACT FINANCING General 732.111 Contract clauses. (a) (b) USAID may obtain short... indefinite quantity contracts that are a combination of contract types. Rather than using the...

  6. 48 CFR 17.109 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 17.109 Section 17.109 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Multiyear Contracting 17.109 Contract clauses. (a)...

  7. 48 CFR 3437.670 - Contract type.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract type. 3437.670... SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Performance-Based Acquisition 3437.670 Contract type. Award-term contracting may be used for performance-based contracts and task orders that...

  8. 48 CFR 916.307 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Contract clauses. 916.307 Section 916.307 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 916.307 Contract clauses. (a)...

  9. 48 CFR 916.307 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Contract clauses. 916.307 Section 916.307 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 916.307 Contract clauses. (a)...

  10. 48 CFR 916.307 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clauses. 916.307 Section 916.307 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 916.307 Contract clauses. (a)...

  11. 48 CFR 916.307 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clauses. 916.307 Section 916.307 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 916.307 Contract clauses. (a)...

  12. 48 CFR 2442.1107 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., Contract Management System, in solicitations and contracts when all of the following conditions apply: (1... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contract clause. 2442.1107... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production Surveillance and Reporting 2442.1107 Contract...

  13. 48 CFR 4.802 - Contract files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract files. 4.802... MATTERS Government Contract Files 4.802 Contract files. (a) A contract file should generally consist of— (1) The contracting office contract file, that documents the basis for the acquisition and the...

  14. Elucidating Protactinium Hydrolysis: The Relative Stabilities of PaO2(H2O)(+) and PaO(OH)2(+).

    PubMed

    Dau, Phuong D; Wilson, Richard E; Gibson, John K

    2015-08-03

    It is demonstrated that the gas-phase oxo-exchange of PaO2(+) with water is substantially faster than that of UO2(+), indicating that the Pa-O bonds are more susceptible to activation and formation of the bis-hydroxide intermediate, PaO(OH)2(+). To elucidate the nature of the water adduct of PaO2(+), hydration of PaO2(+) and UO2(+), as well as collision induced dissociation (CID) and ligand-exchange of the water adducts of PaO2(+) and UO2(+), was studied. The results indicate that, in contrast to UO2(H2O)(+), the protactinium oxo bis-hydroxide isomer, PaO(OH)2(+), is produced as a gas-phase species close in energy to the hydrate isomer, PaO2(H2O)(+). CID behavior similar to that of Th(OH)3(+) supports the assignment as PaO(OH)2(+). The gas-phase results are consistent with the spontaneous hydrolysis of PaO2(+) in aqueous solution, this in contrast to later AnO2(+) (An = U, Np, Pu), which forms stable hydrates in both solution and gas phase. In view of the known propensity for Th(IV) to hydrolyze, and previous gas-phase studies of other AnO2(+), it is concluded that the stabilities of oxo-hydroxides relative to oxide hydrates decreases in the order: Th(IV) > Pa(V) > U(V) > Np(V) > Pu(V). This trend suggests increasing covalency and decreasing ionicity of An-O bonds upon proceeding across the actinide series.

  15. PA014-- Deception and Doubt --Strategies for Undermining and Supporting Global Climate Science--PA014

    NASA Astrophysics Data System (ADS)

    Nelson, C.

    2012-12-01

    DECEPTION AND DOUBT--STRATEGIES FOR UNDERMINING AND SUPPORTING GLOBAL CLIMATE SCIENCE--PA014 The fundamental strategy for undermining confidence in the now substantial scientific consensus about global warming is to sow doubt about the degree of consensus. Rather than mount an obvious anti-science stance, commercial interests seek to champion science, arguing for better science, more complete and definitive science. This strategy has a sixty-year history, beginning with the tobacco industry in the 1950s and proceeding through the chemical, energy, paint, and other industries. Thousands of faculty members have quietly sold themselves as public spokespersons or confidential consultants to industry in the service of this strategy. A multipart program--involving educating people about this history and exposing faculty collaboration--may help free climate science from those who aim to distort its conclusions.

  16. Sliding friction study of the oscillating translational motion for steel on PA66 and PA46 type materials

    NASA Astrophysics Data System (ADS)

    Lates, M. T.; Velicu, R. G.; Papuc, R.

    2016-08-01

    The paper presents the study of the friction, by using tests, in the sliding translational oscillating motion of the steel on PA46 relative to the steel on PA66 type materials by considering as variables the testing parameters as: the load, the velocity and the operating temperature. The paper starts with a study of the literature and, according to that, presents the main conclusions regarding the sliding friction of the steel on PA66 and PA46 type materials and identifies the lacks of the results. The tests are performed on an oscillating motion type tribometer module. First, it is made a running-in program, for each of the materials, at 25 and 90°C, a load of 5 N and a frequency of 1 Hz for one hour; after that, there are performed tests at 90°C and 120°C, at loads of 3 N, 5 N, 7 N and at frequencies at 0.25 Hz, 5 Hz and 1 Hz. The results are presented for the PA46 type material relative to the PA66 material. The conclusions indicate in which conditions and with which advantages are used the PA66 and PA46 polyamides in the case of oscillating translational motions.

  17. SFE/SFHTA/AFCE consensus on primary aldosteronism, part 1: Epidemiology of PA, who should be screened for sporadic PA?

    PubMed

    Baguet, Jean-Philippe; Steichen, Olivier; Mounier-Véhier, Claire; Gosse, Philippe

    2016-07-01

    Depending on the study, the prevalence of primary aldosteronism (PA) in patients with hypertension varies from 6 to 18%. Prevalence is higher in each of the following conditions, any one of which requires screening for PA: severe hypertension (systolic blood pressure [BP]≥180mmHg and/or diastolic BP≥110mmHg); resistant hypertension (systolic BP≥140mmHg and/or diastolic BP≥90mmHg despite adherence to a tritherapy including a thiazide diuretic); hypertension associated with hypokalemia (either spontaneous or associated with a diuretic); Hypertension or hypokalemia associated with adrenal incidentaloma. It should be borne in mind that PA can induce hypertension without hypokalemia or, less frequently, hypokalemia without hypertension. Finally, as cardiovascular and renal morbidity in PA is greater than in essential hypertension of equivalent level, screening for PA is indicated when cardiovascular or renal morbidity is more severe than predicted from BP level.

  18. Cold response in Phalaenopsis aphrodite and characterization of PaCBF1 and PaICE1.

    PubMed

    Peng, Po-Hsin; Lin, Chia-Hui; Tsai, Hui-Wen; Lin, Tsai-Yun

    2014-09-01

    Phalaenopsis is a winter-blooming orchid genus commonly cultivated in tropical Asian countries. Because orchids are one of the most economically important flower crops in Taiwan, it is crucial to understand their response to cold and other abiotic stresses. The present study focused on gene regulation of P. aphrodite in response to abiotic stress, mainly cold. Our results demonstrate that P. aphrodite is sensitive to low temperatures, especially in its reproductive stage. We found that after exposure to 4°C, plants in the vegetative stage maintained better membrane integrity and photosynthetic capacity than in the flowering stage. At the molecular level, C-repeat binding factor1 (PaCBF1) and its putative target gene dehydrin1 (PaDHN1) mRNAs were induced by cold, whereas inducer of CBF expression1 (PaICE1) mRNA was constitutively expressed. PaICE1 transactivated MYC motifs in the PaCBF1 promoter, indicating that up-regulation of PaCBF1 may be mediated by the binding of PaICE1 to MYC motifs. Overexpression of PaCBF1 in transgenic Arabidopsis induced AtCOR6.6 and RD29a without cold stimulus and maintained better membrane integrity after cold stress. Herein, we present evidence that cold induction of PaCBF1 transcripts in P. aphrodite may be transactivated by PaICE1 and consequently protect plants from cold damage through up-regulation of cold-regulated (COR) genes, such as DHN. To our knowledge, this study is the first report of the isolation and characterization of CBF, DHN and ICE genes in the Orchidaceae family.

  19. Biogeography in 231Pa/230Th ratios and a balanced 231Pa budget for the Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Hayes, Christopher T.; Anderson, Robert F.; Fleisher, Martin Q.; Serno, Sascha; Winckler, Gisela; Gersonde, Rainer

    2014-04-01

    The ratio of unsupported protactinium-231 to thorium-230 in marine sediments, (Pa/Th)xs, is potentially sensitive to several processes of oceanographic and climatological interest: deep ocean circulation, marine biological productivity (as it relates to total particle flux) and particle composition (specifically, biogenic opal and authigenic Mn). In order to attribute variations in (Pa/Th)xs observed in sediment records to changes in specific processes through time, a better understanding of the chemical cycling of these elements in the modern ocean is necessary. To this end, a survey was undertaken of (Pa/Th)xs in surface sediments from the subarctic Pacific (SO202-INOPEX expedition) in combination with a Pacific-wide compilation of published data. Throughout the Pacific, (Pa/Th)xs is robustly correlated with the opal content of sediments. In the North and equatorial Pacific, simultaneous positive correlations with productivity indicators suggest that boundary scavenging and opal scavenging combine to enhance the removal of Pa in the eastern equatorial Pacific and subarctic Pacific. Deep ocean water mass ageing (>3.5 km) associated with the Pacific overturning appears to play a secondary role in determining the basin scale distribution of (Pa/Th)xs. A basin-wide extrapolation of Pa removal is performed which suggests that the Pacific Pa budget is nearly in balance. We hypothesize that through time (Pa/Th)xs distributions in the Pacific could define the evolving boundaries of contrasting biogeographic provinces in the North Pacific, while the influence of hydrothermal scavenging of Pa potentially confounds this approach in the South Pacific.

  20. Health contract in the classroom.

    PubMed

    Haber, David

    2007-01-01

    A health contract is a technique used by health professionals to help clients achieve a health goal. This article describes a course, "Changing Health Behaviors," in which a health contract strategy is taught and practiced with older adults. The health contract can also be included as a smaller educational component within a gerontology course that covers risk factors such as sedentary behavior or nutritional deficiency, counseling or health education techniques, or program development. Gerontology students who complete a degree or certificate program may enter a variety of venues in which a health contract can be a useful tool with older clients.

  1. Uterine Contraction Modeling and Simulation

    NASA Technical Reports Server (NTRS)

    Liu, Miao; Belfore, Lee A.; Shen, Yuzhong; Scerbo, Mark W.

    2010-01-01

    Building a training system for medical personnel to properly interpret fetal heart rate tracing requires developing accurate models that can relate various signal patterns to certain pathologies. In addition to modeling the fetal heart rate signal itself, the change of uterine pressure that bears strong relation to fetal heart rate and provides indications of maternal and fetal status should also be considered. In this work, we have developed a group of parametric models to simulate uterine contractions during labor and delivery. Through analysis of real patient records, we propose to model uterine contraction signals by three major components: regular contractions, impulsive noise caused by fetal movements, and low amplitude noise invoked by maternal breathing and measuring apparatus. The regular contractions are modeled by an asymmetric generalized Gaussian function and least squares estimation is used to compute the parameter values of the asymmetric generalized Gaussian function based on uterine contractions of real patients. Regular contractions are detected based on thresholding and derivative analysis of uterine contractions. Impulsive noise caused by fetal movements and low amplitude noise by maternal breathing and measuring apparatus are modeled by rational polynomial functions and Perlin noise, respectively. Experiment results show the synthesized uterine contractions can mimic the real uterine contractions realistically, demonstrating the effectiveness of the proposed algorithm.

  2. Microfluidic manufacture of rt-PA-loaded echogenic liposomes

    PubMed Central

    Kandadai, Madhuvanthi A.; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J.; Papautsky, Ian; Holland, Christy K.

    2016-01-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (µtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the µtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The µtELIP had a mean diameter of 5 µm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5%bovine serum albumin. Additionally, 35 % of µtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes. PMID:27206512

  3. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SECNAVINST 5210.8D). These reports shall be made available to PA program officials and to CNO (DNS-36)/CMC... until the next self-assessment is completed. Make these reports available, upon request, to CNO...

  4. Former Baldwin Hardware Corp. – Reading, PA PAD00235083

    EPA Pesticide Factsheets

    EPA is announcing its proposed decision that includes groundwater remediation, soil vapor capture and treatment as well as restrictions on land and groundwater uses under RCRA for the Baldwin Hardware Corporation facility in Reading PA, EPA ID PAD00235083

  5. Orion PA-1 Flight Test Crew Module Back at Dryden

    NASA Video Gallery

    The boilerplate Orion crew module and separation ring that was flown in the Launch Abort system PA-1 flight test at White Sands Missile Range, N.M., May 6 were airlifted back to NASA Dryden at Edwa...

  6. 78 FR 7848 - Pennsylvania Disaster Number PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00057 AGENCY: U.S. Small Business Administration. ACTION.... ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration, Processing...

  7. RadNet Air Data From Bloomsburg, PA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Bloomsburg, PA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  8. RadNet Air Data From Pittsburgh, PA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Pittsburgh, PA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  9. RadNet Air Data From Philadelphia, PA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Philadelphia, PA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  10. Performance Problems in Service Contracting

    DTIC Science & Technology

    1988-01-01

    technical manual for the U.S. Army. Contract types have run the gamut from firm fixed price to various forms of cost plus arrangements, and award has been...in a National Forest to producing a technical manual for the U.S. Army. Contract types have run the gamut from firm fixed price to various forms of

  11. Profitability Implications of Sustainable Contracting

    DTIC Science & Technology

    2006-08-01

    PROFITABILITY IFUCATIONS OF SUSTAINABLE CONTRACTING BY Dude L Underwood LT, CEC, USN DISTRIBUTION STATEMEMT A Approved for Public Release...Lafayette, Indiana 47907-2051 PROFITABILITY IMPLICATIONS OF SUSTAINABLE CONTRACTING An Independent Research Study Submitted to the Faculty of Purdue...27 iv 4.2. Business Ratio Com parison ................................................................. 27 4.3. Net Profit M argin Com parison

  12. Policing Mechanisms in Agricultural Contracts

    ERIC Educational Resources Information Center

    Wolf, Steven; Hueth, Brent; Ligon, Ethan

    2001-01-01

    In this paper we focus on mechanisms of coordination in agricultural contracts. Our approach is intended to advance understanding of social relations of production and distribution of power in agrofood systems. Through an analysis of contracts between farmers and intermediaries (e.g., processors, shippers, consignment agents) for California fruits…

  13. Two Views on Performance Contracting.

    ERIC Educational Resources Information Center

    Lurie, Sylvia; Smith, Kenneth

    1996-01-01

    North Chicago, Illinois, District 187, received a districtwide overhaul of lighting, heating, ventilation, and security systems through a 10-year performance contract with the Honeywell Corporation. The Briarcliff Manor Union-Free School District, New York, has a contract with Johnson Controls that guarantees a portion of the energy savings…

  14. Contract Education: A Background Paper.

    ERIC Educational Resources Information Center

    California Community Colleges, Sacramento. Academic Senate.

    Today contract education is generally thought of as a program or course for which an employer is paying the full cost of instruction for customized training. Contract education can help faculty remain current, encourage industry to make equipment available to the college that might otherwise be too expensive, and provide employment opportunities…

  15. Neural control of lengthening contractions.

    PubMed

    Duchateau, Jacques; Enoka, Roger M

    2016-01-01

    A number of studies over the last few decades have established that the control strategy employed by the nervous system during lengthening (eccentric) differs from those used during shortening (concentric) and isometric contractions. The purpose of this review is to summarize current knowledge on the neural control of lengthening contractions. After a brief discussion of methodological issues that can confound the comparison between lengthening and shortening actions, the review provides evidence that untrained individuals are usually unable to fully activate their muscles during a maximal lengthening contraction and that motor unit activity during submaximal lengthening actions differs from that during shortening actions. Contrary to common knowledge, however, more recent studies have found that the recruitment order of motor units is similar during submaximal shortening and lengthening contractions, but that discharge rate is systematically lower during lengthening actions. Subsequently, the review examines the mechanisms responsible for the specific control of maximal and submaximal lengthening contractions as reported by recent studies on the modulation of cortical and spinal excitability. As similar modulation has been observed regardless of contraction intensity, it appears that spinal and corticospinal excitability are reduced during lengthening compared with shortening and isometric contractions. Nonetheless, the modulation observed during lengthening contractions is mainly attributable to inhibition at the spinal level.

  16. CONTRACT ADMINISTRATIVE TRACKING SYSTEM (CATS)

    EPA Science Inventory

    The Contract Administrative Tracking System (CATS) was developed in response to an ORD NHEERL, Mid-Continent Ecology Division (MED)-recognized need for an automated tracking and retrieval system for Cost Reimbursable Level of Effort (CR/LOE) Contracts. CATS is an Oracle-based app...

  17. Effects of cyclopiazonic acid and dexamethasone on serotonin-induced calcium responses in vascular smooth muscle cells.

    PubMed

    Selli, Cigdem; Tosun, Metiner

    2016-06-01

    We previously observed that sarcoendoplasmic reticulum Ca(2+) ATPase (SERCA) blockade by cyclopiazonic acid (CPA) significantly potentiates serotonin (5-hydroxytryptamine (5-HT))-induced vascular contractions. Furthermore, 5-HT receptor antagonist methysergide partially inhibited CPA-potentiated 5-HT contractions. In the present study, we further investigated whether SERCA inhibition potentiates 5-HT-induced Ca(2+) responses along with attenuating the receptor antagonism by store-operated Ca(2+) (SOC) entry and protein kinase C (PKC)-mediated mechanisms. The effects of dexamethasone that was previously shown to induce SOC entry and enhance 5-HT responses were also tested. For this purpose, intracellular Ca(2+) levels were monitored in A7r5 embryonic rat vascular smooth muscle cells by spectrofluorometry using the fluorescent indicator fura-2. The results showed that CPA, although not dexamethasone, significantly potentiated 5-HT-induced Ca(2+) elevations. Ketanserin partially decreased 5-HT-induced and CPA-potentiated Ca(2+) elevations whereas both PKC inhibitor D-sphingosine and SOC entry blocker 2-aminoethoxydiphenyl borate (2-APB) abolished the remaining responses. The data suggests that diminished antagonistic effect on 5-HT-induced Ca(2+) elevations in the presence of SERCA inhibition is induced by SOC entry and PKC activation.

  18. Mechanobiology of lymphatic contractions.

    PubMed

    Munn, Lance L

    2015-02-01

    The lymphatic system is responsible for controlling tissue fluid pressure by facilitating flow of lymph (i.e. the plasma and cells that enter the lymphatic system). Because lymph contains cells of the immune system, its transport is not only important for fluid homeostasis, but also immune function. Lymph drainage can occur via passive flow or active pumping, and much research has identified the key biochemical and mechanical factors that affect output. Although many studies and reviews have addressed how tissue properties and fluid mechanics (i.e. pressure gradients) affect lymph transport [1-3] there is less known about lymphatic mechanobiology. As opposed to passive mechanical properties, mechanobiology describes the active coupling of mechanical signals and biochemical pathways. Lymphatic vasomotion is the result of a fascinating system affected by mechanical forces exerted by the flowing lymph, including pressure-induced vessel stretch and flow-induced shear stresses. These forces can trigger or modulate biochemical pathways important for controlling the lymphatic contractions. Here, I review the current understanding of lymphatic vessel function, focusing on vessel mechanobiology, and summarize the prospects for a comprehensive understanding that integrates the mechanical and biomechanical control mechanisms in the lymphatic system.

  19. INFINITY construction contract signed

    NASA Technical Reports Server (NTRS)

    2010-01-01

    Key state and community leaders celebrated April 6 with the signing of a construction contract for the state-of-the-art INFINITY Science Center planned near John C. Stennis Space Center in south Mississippi. Gulfport Mayor George Schloegel (l to r), chair of non-profit INFINITY Science Center Inc., was joined for the signing ceremony at the Hancock Bank in Gulfport by Virginia Wagner, sister of late Hancock Bank President Leo Seal Jr.; and Roy Anderson III, president and CEO of Roy Anderson Corp. Seal was the first chair of INFINITY Science Center Inc., which has led in development of the project. Roy Anderson Corp. plans to begin construction on the 72,000-square-foot, $28 million science and education center in May. The Mississippi Department of Transportation (MDOT) also is set to begin construction of a $2 million access road to the new center. The April 6 ceremony was attended by numerous officials, including former Stennis Space Center Directors Jerry Hlass and Roy Estess; Mississippi Senate President Pro Tempore Billy Hewes, R-Gulfport; Mississippi Rep. Diane Peranich, D-Pass Christian; and MDOT Southern District Commissioner Wayne Brown.

  20. Flow and Heat Transfer Tests in New Loop at 2757 kPa (400 psi)

    SciTech Connect

    Woloshun, Keith Albert

    2016-06-13

    A helium flow and heat transfer experiment has been designed for the new helium flow loop facility at LANL. This new facility is centered on an Aerzen GM 12.4 Root’s blower, selected for operation at higher pressure, up to 2757 kPa, and mass flow rate, up to 400 g/s. This replaces the previous Tuthill PD plus 3206 blower and loop limited to 2067 kPa (300 psi) and 100 g/s. The resistively heated test piece is comprised of 7 electric heaters with embedded thermocouples. The plant design for the Mo100 to Mo99 targets requires sharp bends and geometry changes in the helium flow tube immediately before and after the target. An idealized fully developed flow configuration with straight entry and exit will be tested and compared with an option that employs rectangular tubing to make the bend at a radius consistent with and practical for the actual plant design. The current plant design, with circular tubing and a sudden contraction to rectangular just prior to target entrance, will also be tested. This requires some modification of the test piece, as described in the report.

  1. 48 CFR 1204.103 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 1204.103... ADMINISTRATIVE MATTERS Contract Execution 1204.103 Contract clause. The contracting officer shall insert the clause at (FAR) 48 CFR 52.204-1, Approval of Contract, filled in as appropriate, in solicitations...

  2. 48 CFR 1242.7000 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1242... MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Contract Administration Clauses 1242.7000 Contract clauses. (a) The contracting officer may use the clause at (TAR) 48 CFR 1252.242-70, Dissemination...

  3. 48 CFR 1316.307 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1316.307... CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 1316.307 Contract clauses. (a) Insert a clause that is substantially the same as 1352.216-70, Estimated and Allowable Costs, in all...

  4. 48 CFR 2035.70 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract clauses. 2035.70 Section 2035.70 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 2035.70 Contract clauses. (a) The contracting officer...

  5. 48 CFR 2035.70 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract clauses. 2035.70 Section 2035.70 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 2035.70 Contract clauses. (a) The contracting officer...

  6. 48 CFR 2035.70 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contract clauses. 2035.70 Section 2035.70 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 2035.70 Contract clauses. (a) The contracting officer...

  7. 48 CFR 2035.70 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contract clauses. 2035.70 Section 2035.70 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 2035.70 Contract clauses. (a) The contracting officer...

  8. 48 CFR 2035.70 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clauses. 2035.70 Section 2035.70 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 2035.70 Contract clauses. (a) The contracting officer...

  9. 48 CFR 316.603 - Letter contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Letter contracts. 316.603 Section 316.603 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 316.603...

  10. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  11. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  12. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  13. 48 CFR 43.205 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 43.205 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 43.205 Contract clauses. (a)(1) The contracting officer shall insert the clause at 52.243-1, Changes—Fixed-Price, in solicitations and contracts when a...

  14. 48 CFR 43.205 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Section 43.205 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 43.205 Contract clauses. (a)(1) The contracting officer shall insert the clause at 52.243-1, Changes—Fixed-Price, in solicitations and contracts when a...

  15. 48 CFR 543.205 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 543.205 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 543.205 Contract clauses. The contracting officer shall insert 552.243-71, Equitable Adjustments, in solicitations and contracts containing FAR 52.243-4, Changes....

  16. 48 CFR 543.205 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Section 543.205 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 543.205 Contract clauses. The contracting officer shall insert 552.243-71, Equitable Adjustments, in solicitations and contracts containing FAR 52.243-4, Changes....

  17. 48 CFR 42.401 - Contract correspondence.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract correspondence... MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Correspondence and Visits 42.401 Contract correspondence. (a) The contracting officer (or other contracting agency personnel) normally shall (1)...

  18. 48 CFR 42.401 - Contract correspondence.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contract correspondence... MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Correspondence and Visits 42.401 Contract correspondence. (a) The contracting officer (or other contracting agency personnel) normally shall (1)...

  19. 48 CFR 42.401 - Contract correspondence.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Contract correspondence... MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Correspondence and Visits 42.401 Contract correspondence. (a) The contracting officer (or other contracting agency personnel) normally shall (1)...

  20. 48 CFR 42.401 - Contract correspondence.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract correspondence... MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Correspondence and Visits 42.401 Contract correspondence. (a) The contracting officer (or other contracting agency personnel) normally shall (1)...

  1. 48 CFR 42.401 - Contract correspondence.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Contract correspondence... MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Correspondence and Visits 42.401 Contract correspondence. (a) The contracting officer (or other contracting agency personnel) normally shall (1)...

  2. 48 CFR 846.312 - Construction contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Construction contracts. 846.312 Section 846.312 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.312 Construction contracts. The contracting officer...

  3. 48 CFR 16.603 - Letter contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Letter contracts. 16.603 Section 16.603 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts...

  4. 48 CFR 1517.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve...

  5. 48 CFR 317.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  6. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contracts. 631.10 Section 631.10 Agriculture... AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a) To participate in the program, an applicant must enter into a contract agreeing to implement a conservation...

  7. 24 CFR 232.605 - Contract requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Contract requirements. 232.605... Fire Safety Equipment Form of Contract § 232.605 Contract requirements. (a) The contract between the mortgagor and the general contractor may be in the form of either a lump sum contract or a cost...

  8. 48 CFR 837.403 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 837.403... OF CONTRACTING SERVICE CONTRACTING Nonpersonal Health Care Services 837.403 Contract clause. The contracting officer shall insert the clause at 852.237-7, Indemnification and medical liability insurance,...

  9. 48 CFR 217.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contracts. 217.204 Section... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 217.204 Contracts. (e)(i) Notwithstanding FAR 17.204(e), the ordering period of a task order or delivery order...

  10. 48 CFR 811.503 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 811.503... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Liquidated Damages 811.503 Contract clause. When the contracting... contracting officer must include the clause in 852.211-74, Liquidated damages, in the contract....

  11. 48 CFR 617.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Contracts. 617.204 Section 617.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 617.204 Contracts. (e) The Procurement Executive shall...

  12. 48 CFR 217.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contracts. 217.204 Section... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 217.204 Contracts. (e)(i) Notwithstanding FAR 17.204(e), the ordering period of a task order or delivery order...

  13. 48 CFR 317.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  14. 48 CFR 846.312 - Construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Construction contracts. 846.312 Section 846.312 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.312 Construction contracts. The contracting officer...

  15. 7 CFR 632.22 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Contracts. 632.22 Section 632.22 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM Participation § 632.22 Contracts. (a) Cost-sharing contracts. A land user who has an approved reclamation plan may enter into a contract with NRCS...

  16. 43 CFR 2.228 - Government contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Government contracts. 2.228 Section 2.228... TESTIMONY Privacy Act § 2.228 Government contracts. (a) Required contract provisions. When a contract... Department function, the contract shall, consistent with the Department's authority, cause the...

  17. 48 CFR 217.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Contracts. 217.204 Section... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 217.204 Contracts. (e)(i) Notwithstanding FAR 17.204(e), the ordering period of a task order or delivery order...

  18. 48 CFR 16.503 - Requirements contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Requirements contracts. 16.503 Section 16.503 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Indefinite-Delivery Contracts 16.503 Requirements...

  19. 48 CFR 1517.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve...

  20. 7 CFR 634.25 - Contracting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Contracting. 634.25 Section 634.25 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.25 Contracting. (a) To participate in RCWP, a landowner or operator must enter into a contract in which he or...

  1. 48 CFR 617.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Contracts. 617.204 Section 617.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 617.204 Contracts. (e) The Procurement Executive shall...

  2. 7 CFR 800.198 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Contracts. 800.198 Section 800.198 Agriculture..., Designations, Approvals, Contracts, and Conflicts of Interest § 800.198 Contracts. (a) Services contracted and who may apply. The Service may enter into a contract with any person, State, or governmental agency...

  3. 48 CFR 3432.705 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clauses. 3432.705 Section 3432.705 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 3432.705 Contract clauses....

  4. 7 CFR 634.25 - Contracting.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Contracting. 634.25 Section 634.25 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.25 Contracting. (a) To participate in RCWP, a landowner or operator must enter into a contract in which he or...

  5. 48 CFR 317.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  6. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Contracts. 631.10 Section 631.10 Agriculture... AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a) To participate in the program, an applicant must enter into a contract agreeing to implement a conservation...

  7. 48 CFR 617.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Contracts. 617.204 Section 617.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 617.204 Contracts. (e) The Procurement Executive shall...

  8. 48 CFR 617.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracts. 617.204 Section 617.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 617.204 Contracts. (e) The Procurement Executive shall...

  9. 7 CFR 634.25 - Contracting.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Contracting. 634.25 Section 634.25 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.25 Contracting. (a) To participate in RCWP, a landowner or operator must enter into a contract in which he or...

  10. 48 CFR 837.403 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 837.403... OF CONTRACTING SERVICE CONTRACTING Nonpersonal Health Care Services 837.403 Contract clause. The contracting officer shall insert the clause at 852.237-7, Indemnification and medical liability insurance,...

  11. 48 CFR 846.312 - Construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Construction contracts. 846.312 Section 846.312 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.312 Construction contracts. The contracting officer...

  12. 48 CFR 837.403 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clause. 837.403... OF CONTRACTING SERVICE CONTRACTING Nonpersonal Health Care Services 837.403 Contract clause. The contracting officer shall insert the clause at 852.237-7, Indemnification and medical liability insurance,...

  13. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Contracts. 631.10 Section 631.10 Agriculture... AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a) To participate in the program, an applicant must enter into a contract agreeing to implement a conservation...

  14. 48 CFR 19.812 - Contract administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract administration... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 19.812 Contract administration. (a) The contracting officer shall assign contract...

  15. 48 CFR 4.1303 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 4.1303... ADMINISTRATIVE MATTERS Personal Identity Verification 4.1303 Contract clause. The contracting officer shall... and contracts when contract performance requires contractors to have routine physical access to...

  16. 48 CFR 1517.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve...

  17. 48 CFR 822.305 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 822.305... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Contract Work Hours and Safety Standards Act 822.305 Contract clause. The contracting officer shall insert the clause at 852.222-70, Contract...

  18. 7 CFR 800.198 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false Contracts. 800.198 Section 800.198 Agriculture..., Designations, Approvals, Contracts, and Conflicts of Interest § 800.198 Contracts. (a) Services contracted and who may apply. The Service may enter into a contract with any person, State, or governmental agency...

  19. 48 CFR 217.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contracts. 217.204 Section... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 217.204 Contracts. (e)(i) Notwithstanding FAR 17.204(e), the ordering period of a task order or delivery order...

  20. 48 CFR 822.305 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 822.305... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Contract Work Hours and Safety Standards Act 822.305 Contract clause. The contracting officer shall insert the clause at 852.222-70, Contract...

  1. 48 CFR 2417.204 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts. 2417.204 Section 2417.204 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CONTRACTING METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e) The...

  2. 43 CFR 2.53 - Government contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Government contracts. 2.53 Section 2.53... INFORMATION ACT Privacy Act § 2.53 Government contracts. (a) Required contract provisions. When a contract... Department function, the contract shall, consistent with the Department's authority, cause the...

  3. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Contracts. 631.10 Section 631.10 Agriculture... AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a) To participate in the program, an applicant must enter into a contract agreeing to implement a conservation...

  4. 48 CFR 317.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  5. 48 CFR 317.204 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  6. 7 CFR 634.26 - Contract modifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contract modifications. 634.26 Section 634.26..., DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.26 Contract modifications. (a) The administering agency may modify contracts previously entered into if it...

  7. 48 CFR 1517.204 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve...

  8. 7 CFR 632.22 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Contracts. 632.22 Section 632.22 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM Participation § 632.22 Contracts. (a) Cost-sharing contracts. A land user who has an approved reclamation plan may enter into a contract with NRCS...

  9. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  10. 24 CFR 891.560 - HAP contract.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false HAP contract. 891.560 Section 891... Assistance § 891.560 HAP contract. (a) HAP contract. The housing assistance payments contract sets forth.... (b) HAP contract execution. (1) Upon satisfactory completion of the project, the Borrower and...

  11. 7 CFR 634.25 - Contracting.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Contracting. 634.25 Section 634.25 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.25 Contracting. (a) To participate in RCWP, a landowner or operator must enter into a contract in which he or...

  12. 48 CFR 811.503 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.503... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Liquidated Damages 811.503 Contract clause. When the contracting... contracting officer must include the clause in 852.211-74, Liquidated damages, in the contract....

  13. 7 CFR 800.198 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Contracts. 800.198 Section 800.198 Agriculture..., Designations, Approvals, Contracts, and Conflicts of Interest § 800.198 Contracts. (a) Services contracted and who may apply. The Service may enter into a contract with any person, State, or governmental agency...

  14. 7 CFR 632.22 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contracts. 632.22 Section 632.22 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM Participation § 632.22 Contracts. (a) Cost-sharing contracts. A land user who has an approved reclamation plan may enter into a contract with NRCS...

  15. 7 CFR 631.10 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Contracts. 631.10 Section 631.10 Agriculture... AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.10 Contracts. (a) To participate in the program, an applicant must enter into a contract agreeing to implement a conservation...

  16. 7 CFR 632.22 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Contracts. 632.22 Section 632.22 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM Participation § 632.22 Contracts. (a) Cost-sharing contracts. A land user who has an approved reclamation plan may enter into a contract with NRCS...

  17. 7 CFR 632.22 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Contracts. 632.22 Section 632.22 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM Participation § 632.22 Contracts. (a) Cost-sharing contracts. A land user who has an approved reclamation plan may enter into a contract with NRCS...

  18. 7 CFR 631.14 - Contract violations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contract violations. 631.14 Section 631.14 Agriculture... AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM Contracts § 631.14 Contract violations. Contract violations, determinations and appeals will be handled in accordance with the terms of...

  19. 42 CFR 434.40 - Contract requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Contract requirements. 434.40 Section 434.40 Public...) MEDICAL ASSISTANCE PROGRAMS CONTRACTS Contracts With Health Insuring Organizations § 434.40 Contract requirements. (a) Contracts with health insuring organizations that are not subject to the requirements...

  20. 48 CFR 617.204 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contracts. 617.204 Section 617.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 617.204 Contracts. (e) The Procurement Executive shall...

  1. 7 CFR 634.25 - Contracting.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contracting. 634.25 Section 634.25 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.25 Contracting. (a) To participate in RCWP, a landowner or operator must enter into a contract in which he or...

  2. 7 CFR 800.198 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Contracts. 800.198 Section 800.198 Agriculture..., Designations, Approvals, Contracts, and Conflicts of Interest § 800.198 Contracts. (a) Services contracted and who may apply. The Service may enter into a contract with any person, State, or governmental agency...

  3. 48 CFR 217.204 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Contracts. 217.204 Section... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 217.204 Contracts. (e)(i) Notwithstanding FAR 17.204(e), the ordering period of a task order or delivery order...

  4. 43 CFR 2.228 - Government contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Government contracts. 2.228 Section 2.228... TESTIMONY Privacy Act § 2.228 Government contracts. (a) Required contract provisions. When a contract... Department function, the contract shall, consistent with the Department's authority, cause the...

  5. 29 CFR 4.107 - Federal contracts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Federal contracts. 4.107 Section 4.107 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the McNamara-O'Hara Service Contract Act Agencies Whose Contracts May Be Covered § 4.107 Federal contracts. (a) Section 2(a) of the...

  6. 25 CFR 502.15 - Management contract.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Management contract. 502.15 Section 502.15 Indians... CHAPTER § 502.15 Management contract. Management contract means any contract, subcontract, or collateral... contract or agreement provides for the management of all or part of a gaming operation....

  7. 7 CFR 800.198 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Contracts. 800.198 Section 800.198 Agriculture..., Designations, Approvals, Contracts, and Conflicts of Interest § 800.198 Contracts. (a) Services contracted and who may apply. The Service may enter into a contract with any person, State, or governmental agency...

  8. 48 CFR 217.7702 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Over and Above Work 217.7702 Contract clause. Use the clause at 252.217-7028, Over and Above Work, in solicitations and contracts containing requirements for over and above work, except as provided for in subpart 217.71....

  9. 48 CFR 1235.7000 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in all solicitations and contracts for research and development. For further information, see...

  10. 48 CFR 1235.7000 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in all solicitations and contracts for research and development. For further information, see...

  11. 48 CFR 36.508 - Other contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Other contracts. 36.508 Section 36.508 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 36.508 Other contracts....

  12. 48 CFR 36.508 - Other contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Other contracts. 36.508 Section 36.508 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 36.508 Other contracts....

  13. 48 CFR 36.508 - Other contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Other contracts. 36.508 Section 36.508 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 36.508 Other contracts....

  14. 48 CFR 36.508 - Other contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Other contracts. 36.508 Section 36.508 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 36.508 Other contracts....

  15. 48 CFR 36.508 - Other contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Other contracts. 36.508 Section 36.508 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 36.508 Other contracts....

  16. 48 CFR 2442.1107 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... clause at 2452.242-71, Contract Management System, in solicitations and contracts when all of the... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contract clause. 2442.1107... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Production Surveillance and Reporting...

  17. 48 CFR 3443.106 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contract clause. 3443.106 Section 3443.106 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS 3443.106 Contract clause. The contracting officer shall...

  18. 29 CFR 4.107 - Federal contracts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Federal contracts. 4.107 Section 4.107 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the McNamara-O'Hara Service Contract Act Agencies Whose Contracts May Be Covered § 4.107 Federal contracts. (a) Section 2(a) of the...

  19. The Pediocin PA-1 Accessory Protein Ensures Correct Disulfide Bond Formation in the Antimicrobial Peptide Pediocin PA-1.

    PubMed

    Oppegård, Camilla; Fimland, Gunnar; Anonsen, Jan Haug; Nissen-Meyer, Jon

    2015-05-19

    Peptides, in contrast to proteins, are generally not large enough to form stable and well-defined three-dimensional structures. However, peptides are still able to form correct disulfide bonds. Using pediocin-like bacteriocins, we have examined how this may be achieved. Some pediocin-like bacteriocins, such as pediocin PA-1 and sakacin P[N24C+44C], have four cysteines. There are three possible ways by which the four cysteines may combine to form two disulfide bonds, and the three variants are expected to be produced in approximately equal amounts if their formation is random. Pediocin PA-1 and sakacin P[N24C+44C] with correct disulfide bonds were the main products when they were secreted by the pediocin PA-1 ABC transporter and accessory protein, but when they were secreted by the corresponding secretion machinery for sakacin A, a pediocin-like bacteriocin with one disulfide bond (two cysteines), peptides with all three possible disulfide bonds were produced in approximately equal amounts. All five cysteines in the pediocin PA-1 ABC transporter and the two cysteines (that form a CxxC motif) in the accessory protein were individually replaced with serines to examine their involvement in disulfide bond formation in pediocin PA-1. The Cys86Ser mutation in the accessory protein caused a 2-fold decrease in the amount of pediocin PA-1 with correct disulfide bonds, while the Cys83Ser mutation nearly abolished the production of pediocin PA-1 and resulted in the production of all three disufide bond variants in equal amounts. The Cys19Ser mutation in the ABC transporter completely abolished secretion of pediocin PA-1, suggesting that Cys19 is in the proteolytic active site and involved in cleaving the prebacteriocin. Replacing the other four cysteines in the ABC transporter with serines caused a slight reduction in the overall amount of secreted pediocin PA-1, but the relative amount with the correct disulfide bonds remained large. These results indicate that the pediocin

  20. Detection of anthrax protective antigen (PA) using europium labeled anti-PA monoclonal antibody and time-resolved fluorescence.

    PubMed

    Stoddard, Robyn A; Quinn, Conrad P; Schiffer, Jarad M; Boyer, Anne E; Goldstein, Jason; Bagarozzi, Dennis A; Soroka, Stephen D; Dauphin, Leslie A; Hoffmaster, Alex R

    2014-06-01

    Inhalation anthrax is a rare but acute infectious disease following adsorption of Bacillus anthracis spores through the lungs. The disease has a high fatality rate if untreated, but early and correct diagnosis has a significant impact on case patient recovery. The early symptoms of inhalation anthrax are, however, non-specific and current anthrax diagnostics are primarily dependent upon culture and confirmatory real-time PCR. Consequently, there may be a significant delay in diagnosis and targeted treatment. Rapid, culture-independent diagnostic tests are therefore needed, particularly in the context of a large scale emergency response. The aim of this study was to evaluate the ability of monoclonal antibodies to detect anthrax toxin proteins that are secreted early in the course of B. anthracis infection using a time-resolved fluorescence (TRF) immunoassay. We selected monoclonal antibodies that could detect protective antigen (PA), as PA83 and also PA63 and LF in the lethal toxin complex. The assay reliable detection limit (RDL) was 6.63×10(-6)μM (0.551ng/ml) for PA83 and 2.51×10(-5)μM (1.58ng/ml) for PA63. Despite variable precision and accuracy of the assay, PA was detected in 9 out of 10 sera samples from anthrax confirmed case patients with cutaneous (n=7), inhalation (n=2), and gastrointestinal (n=1) disease. Anthrax Immune Globulin (AIG), which has been used in treatment of clinical anthrax, interfered with detection of PA. This study demonstrates a culture-independent method of diagnosing anthrax through the use of monoclonal antibodies to detect PA and LF in the lethal toxin complex.

  1. Insights Into the PA Neutral Atom: from AN Evaluation of PA2+ Outer-Core Correlation Energy Calculations

    NASA Astrophysics Data System (ADS)

    Mrozik, Michael K.; Pitzer, Russell M.; Bursten, Bruce E.

    2010-06-01

    Since the identification of f-orbital contribution to the bonding in PaO+, investigations into Pa cations have hoped to characterize as many of the electronic states possible.1 Electronic states of the Pan+ (n=0-4) ions have been investigated using multi-reference spin-orbit configuration interaction (MR-SOCI). Initial investigations using Dunning style correlation consistent double-{ζ} basis sets are re-examined with a larger triple-{ζ} basis, with the hope of supporting the order of electronic states. Calculations using Hartree-Fock and CI calculations on the neutral atom did not produce the known order of states. A case study was deemed necessary on similar electron configurations present in the low energy states of Pa2+ more specifically those generated from the 5f26d1 and 5f16d2 configurations. Comparison in the Pa2+ ion is complicated by the lack of experimental results, but the states are presumed to be similar sequence as those in the neutral atom, with the addition of two electrons in the 7s shell. In evaluating the impact of inclusion of the outer core, calculations including valence-outer core correlation were completed for the 5d, 6s, and 6p shells of the Pa2+ ion. The magnitude of these individual shell correlation calculations will allow for identification of the energy level shifts associated with even and odd configurations, better describing the energy order in both the Pa2+ ion case study and for the neutral Pa atom. Upon completion of this aspect of the Pa neutral atom study, the knowledge of the energy levels in the Pan+ (n=0-4) family of ions will be greatly expanded, and may yield a model for future studies of atomic actinide systems. Gibson {et al.} Organometallics 2007, 26, 3947-3956.

  2. Active contraction of microtubule networks

    PubMed Central

    Foster, Peter J; Fürthauer, Sebastian; Shelley, Michael J; Needleman, Daniel J

    2015-01-01

    Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the large-scale behaviors of these systems. Here, we investigate the self-organization of stabilized microtubules in Xenopus oocyte extracts and find that they can form macroscopic networks that spontaneously contract. We propose that these contractions are driven by the clustering of microtubule minus ends by dynein. Based on this idea, we construct an active fluid theory of network contractions, which predicts a dependence of the timescale of contraction on initial network geometry, a development of density inhomogeneities during contraction, a constant final network density, and a strong influence of dynein inhibition on the rate of contraction, all in quantitative agreement with experiments. These results demonstrate that the motor-driven clustering of filament ends is a generic mechanism leading to contraction. DOI: http://dx.doi.org/10.7554/eLife.10837.001 PMID:26701905

  3. Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa

    SciTech Connect

    Jacewicz, Agata; Schnell, Robert; Lindqvist, Ylva; Schneider, Gunter

    2016-01-22

    PA4991 is a FAD-dependent oxidoreductase from the pathogen P. aeruginosa that is essential for virulence and survival in the infected host. The structure of this enzyme, determined to 2.4 Å resolution, reveals that PA4991 belongs to the GR{sub 2} family of flavoenzymes. The locus PA4991 in Pseudomonas aeruginosa encodes an open reading frame that has been identified as essential for the virulence and/or survival of this pathogenic organism in the infected host. Here, it is shown that this gene encodes a monomeric FAD-binding protein of molecular mass 42.2 kDa. The structure of PA4991 was determined by a combination of molecular replacement using a search model generated with Rosetta and phase improvement by a low-occupancy heavy-metal derivative. PA4991 belongs to the GR{sub 2} family of FAD-dependent oxidoreductases, comprising an FAD-binding domain typical of the glutathione reductase family and a second domain dominated by an eight-stranded mixed β-sheet. Most of the protein–FAD interactions are via the FAD-binding domain, but the isoalloxazine ring is located at the domain interface and interacts with residues from both domains. A comparison with the structurally related glycine oxidase and glycerol-3-phosphate dehydrogenase shows that in spite of very low amino-acid sequence identity (<18%) several active-site residues involved in substrate binding in these enzymes are conserved in PA4991. However, enzymatic assays show that PA4991 does not display amino-acid oxidase or glycerol-3-phosphate dehydrogenase activities, suggesting that it requires different substrates for activity.

  4. Utilization of Award Fee Contracts at Navy Regional Contracting Centers

    DTIC Science & Technology

    1992-12-01

    California 92132-5106 8. Ellen H. Polen 1 Navy Regional Contracting Center, Detachment Long Beach Long Beach, California 90822-5095 9. LT Mark E. Hogenmiller 1 P.O. Box 3601 Erie, Pennsylvania 1650P-0601 77

  5. Defining Acquisition and Contracting Terms Associated with Contract Administration

    DTIC Science & Technology

    1990-09-01

    5-11 5.5. Constructive Change Survey Results ..... ................ 5-14 5.6. Cure Notice Survey Results ...... ..................... 5- 16 5.7...Contracting spe - cialists are continually dealing with engineering, manufacturing, quality control, data management, pricing, legal, industry, auditing, and...these duties into general categories, as outlined in the ASPM and Government Contract Cost ( 16 :B-3) (36:25-7,GL-3). NCMA’s Desktop Guide to Basic

  6. Contracting With the Enemy: The Contracting Officer’s Dilemma

    DTIC Science & Technology

    2015-06-01

    contracting with the enemy, Congress included a policy rider in the 2012 NDAA aimed at prohibiting the award of contracts to enemy persons or entities...reiterating the results of our research and identifying a policy recommendation aimed at better managing the enemy contractor predicament. 76...AGENCY REPORT NUMBER 11. SUPPLEMENTARY NOTES The views expressed in this thesis are those of the author and do not reflect the official policy

  7. 48 CFR 211.503 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... (b) Use the clause at FAR 52.211-12, Liquidated Damages—Construction, in all construction contracts exceeding $650,000, except cost-plus-fixed-fee contracts or contracts where the contractor cannot...

  8. 20 CFR 435.48 - Contract provisions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Employees' Benefits SOCIAL SECURITY ADMINISTRATION UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND... contracting (or subcontracting) for construction or facility improvements must provide for the recipient to... construction contract or subcontract exceeds $100,000. For those contracts or subcontracts exceeding...

  9. 7 CFR 1469.21 - Contract requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CONSERVATION SECURITY PROGRAM Contracts and... conservation stewardship contract and comply with its provisions. Among other provisions, the participant... payments from one conservation stewardship contract. (c) CSP participants must address the...

  10. 7 CFR 1469.21 - Contract requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CONSERVATION SECURITY PROGRAM Contracts and... conservation stewardship contract and comply with its provisions. Among other provisions, the participant... payments from one conservation stewardship contract. (c) CSP participants must address the...

  11. 7 CFR 1469.21 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CONSERVATION SECURITY PROGRAM Contracts and... conservation stewardship contract and comply with its provisions. Among other provisions, the participant... payments from one conservation stewardship contract. (c) CSP participants must address the...

  12. 48 CFR 19.708 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Contracting by sealed bidding rather than by negotiation, the contracting officer shall use the clause with.... (iii) The contract action will not be reported in the Federal Procurement Data System pursuant to...

  13. 77 FR 37907 - Information Collection; Service Contracting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ...; Service Contracting AGENCIES: Department of Defense (DOD), General Services Administration (GSA), and... requirement concerning service contracting. Public comments are particularly invited on: Whether this...- 0152, Service Contracting, by any of the following methods: Regulations.gov :...

  14. 78 FR 11699 - International Mail Contract

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is... Contract 3 Negotiated Service Agreement. This notice informs the public of the filing, invites public... entered into an additional International Business Reply Service (IBRS) Competitive Contract 3...

  15. 48 CFR 1.602 - Contracting officers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contracting officers. 1... FEDERAL ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities 1.602 Contracting officers....

  16. 48 CFR 2901.602 - Contracting officers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contracting officers. 2901... LABOR ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 2901.602 Contracting officers....

  17. 48 CFR 1401.602 - Contracting officers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracting officers. 1401... DEPARTMENT OF THE INTERIOR ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 1401.602 Contracting officers....

  18. 77 FR 76091 - International Mail Contract

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is... international mail contract. This document invites public comments on the request and addresses several related... an expired International Business Reply Service (IBRS) competitive contract.\\1\\ The Postal...

  19. 77 FR 3288 - International Mail Contract

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ... Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing... Package contract. This document invites public comments on the request and addresses several related... additional Global Reseller Expedited Package (GREP) contract.\\1\\ The Postal Service believes the...

  20. 48 CFR 1450.103 - Contract adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract adjustments. 1450.103 Section 1450.103 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT... Contract adjustments....

  1. 78 FR 11237 - International Mail Contract

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recent Postal Service filing concerning an additional Global Reseller Expedited Package Contract... entered into an additional Global Reseller Expedited Package Contracts 1 negotiated service...

  2. 77 FR 16568 - International Mail Contract

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is... Service contract. This document invites public comments on the request and addresses several related... has entered into an additional International Business Reply Service (IBRS) contract.\\1\\ The...

  3. 48 CFR 3030.201 - Contract requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract requirements. 3030... SECURITY ACQUISITION REGULATION (HSAR) GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 3030.201 Contract requirements....

  4. Utility Energy Services Contracts: Enabling Documents

    SciTech Connect

    2009-05-01

    Utility Energy Services Contracts: Enabling Documents provides materials that clarify the authority for Federal agencies to enter into utility energy services contracts (UESCs), as well as sample documents and resources to ease utility partnership contracting.

  5. 76 FR 81807 - Operational Contract Support

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... include: (1) Incorporation of lessons learned from current operations; (2) requirements for the... contract support (OCS). The ability to orchestrate and synchronize the provision of integrated contract..., integrate, and execute acquisition of, contracted support, including synchronizing and...

  6. 48 CFR 511.404 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Stock replenishment contracts. The contracting officer shall insert 552.211-81, Time of Shipment, in solicitations and stock replenishment contracts that do not include the Availability for Inspection,...

  7. Contracts in radiology practices: contract types and key provisions.

    PubMed

    Muroff, Julie A; Muroff, Lawrence R

    2004-07-01

    A contract between a radiology group and its physician member(s) provides the foundation for the professional relationships in a group practice. The parties are not in positions of parity; contract provisions are structured to maintain the primacy of the group over the individual members. An integration clause should be included to preclude reliance on communications that are not memorialized by the language of the contract. Precise, unambiguous terms must be used to convey the intentions of the parties. The contract should have a clear date of initiation and, if applicable, an effective date of termination. Mechanisms for termination and modification should be expressed clearly to minimize the risk of judicial interference. The method of determining and adjusting the salary and other benefits of the radiologist should be stated, as consideration is necessary to support the existence of a legal contract. The obligations of the radiologist to the practice are often stated in general terms to maximize the group's flexibility. Finally, other key clauses that are discussed in the paper should be incorporated into the contract.

  8. 231Pa systematics in postglacial volcanic rocks from Iceland

    NASA Astrophysics Data System (ADS)

    Turner, Simon; Kokfelt, Thomas; Hoernle, Kaj; Lundstrom, Craig; Hauff, Folkmar

    2016-07-01

    Several recent studies have highlighted the potential of combined 238U-230Th and 235U-231Pa systematics to constrain upwelling rates and the role of recycled mafic lithologies in mantle plume-derived basalts. Accordingly, we present measurements of the 231Pa concentrations from 26 mafic volcanic rocks from Iceland, including off-axis basalts from the Snaefellsnes Peninsula, to complement previously published 238U-230Th-226Ra data. 231Pa concentrations vary from 27 to 624 fg/g and (231Pa/235U) ratios from 1.12 to 2.11 with the exception of one anomalous sample from the Southeast Rift which has a 231Pa deficit with (231Pa/235U) = 0.86. An important new result is that basalts from the Southeast Rift and the Snaefellsnes Peninsula define a trend at relatively low (231Pa/235U) for a given (230Th/238U) ratio. Many of the remaining samples fall in or around the global field for ocean island basalts but those from the Mid-Iceland Belt and the Southwest Rift/Reykjanes Peninsula extend to higher (231Pa/235U) ratios at a given (230Th/238U), similar to mid-ocean ridge basalts. In principle, these lavas could result from melting of peridotite at lower pressures. However, there is no reason to suspect that the Mid-Iceland Belt and the Southwest Rift lavas reflect shallower melting than elsewhere in Iceland. In our preferred model, these lavas reflect melting of garnet peridotite whereas those from the Southeast Rift and the Snaefellsnes Peninsula contain a significant contribution (up to 20%) of melt from garnet pyroxenite. This is consistent with incompatible trace element and radiogenic isotope evidence for recycled oceanic crust in these lavas. There is increasing agreement that the displacement of ocean island basalts to lower (231Pa/235U) ratios at a given (230Th/238U), compared to mid-ocean ridge basalts, reflects the role of recycled mafic lithologies such as garnet pyroxenite as well as higher average pressures of melting. It now seems likely that this interpretation may

  9. 40 CFR 35.4235 - Are there specific provisions my group's contract(s) must contain?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Suspension and Debarment; (g) The following clauses from 40 CFR 30.48: (1) Remedies for breaches of contract...'s contract(s) must contain? 35.4235 Section 35.4235 Protection of Environment ENVIRONMENTAL... provisions my group's contract(s) must contain? Your group must include the following provisions in each...

  10. The constant beat: cardiomyocytes adapt their forces by equal contraction upon environmental stiffening.

    PubMed

    Hersch, Nils; Wolters, Benjamin; Dreissen, Georg; Springer, Ronald; Kirchgeßner, Norbert; Merkel, Rudolf; Hoffmann, Bernd

    2013-03-15

    Cardiomyocytes are responsible for the permanent blood flow by coordinated heart contractions. This vital function is accomplished over a long period of time with almost the same performance, although heart properties, as its elasticity, change drastically upon aging or as a result of diseases like myocardial infarction. In this paper we have analyzed late rat embryonic heart muscle cells' morphology, sarcomere/costamere formation and force generation patterns on substrates of various elasticities ranging from ∼1 to 500 kPa, which covers physiological and pathological heart stiffnesses. Furthermore, adhesion behaviour, as well as single myofibril/sarcomere contraction patterns, was characterized with high spatial resolution in the range of physiological stiffnesses (15 kPa to 90 kPa). Here, sarcomere units generate an almost stable contraction of ∼4%. On stiffened substrates the contraction amplitude remains stable, which in turn leads to increased force levels allowing cells to adapt almost instantaneously to changing environmental stiffness. Furthermore, our data strongly indicate specific adhesion to flat substrates via both costameric and focal adhesions. The general appearance of the contractile and adhesion apparatus remains almost unaffected by substrate stiffness.

  11. Efficacy of histotripsy combined with rt-PA in vitro

    NASA Astrophysics Data System (ADS)

    Bader, Kenneth B.; Haworth, Kevin J.; Shekhar, Himanshu; Maxwell, Adam D.; Peng, Tao; McPherson, David D.; Holland, Christy K.

    2016-07-01

    Histotripsy, a form of therapeutic ultrasound that uses the mechanical action of microbubble clouds for tissue ablation, is under development to treat chronic deep vein thrombosis (DVT). We hypothesize that combining thrombolytic agents with histotripsy will enhance clot lysis. Recombinant tissue plasminogen activator (rt-PA) and rt-PA-loaded echogenic liposomes that entrain octafluoropropane microbubbles (OFP t-ELIP) were used in combination with highly shocked histotripsy pulses. Fully retracted porcine venous clots, with similar features of DVT occlusions, were exposed either to histotripsy pulses alone (peak negative pressures of 7-20 MPa), histotripsy and OFP t-ELIP, or histotripsy and rt-PA. Microbubble cloud activity was monitored with passive cavitation imaging during histotripsy exposure. The power levels of cavitation emissions from within the clot were not statistically different between treatment types, likely due to the near instantaneous rupture and destruction of OFP t-ELIP. The thrombolytic efficacy was significantly improved in the presence of rt-PA. These results suggest the combination of histotripsy and rt-PA could serve as a potent therapeutic strategy for the treatment of DVT.

  12. Morphological studies on block copolymer modified PA 6 blends

    NASA Astrophysics Data System (ADS)

    Poindl, M.; Bonten, C.

    2014-05-01

    Recent studies show that compounding polyamide 6 (PA 6) with a PA 6 polyether block copolymers made by reaction injection molding (RIM) or continuous anionic polymerization in a reactive extrusion process (REX) result in blends with high impact strength and high stiffness compared to conventional rubber blends. In this paper, different high impact PA 6 blends were prepared using a twin screw extruder. The different impact modifiers were an ethylene propylene copolymer, a PA PA 6 polyether block copolymer made by reaction injection molding and one made by reactive extrusion. To ensure good particle matrix bonding, the ethylene propylene copolymer was grafted with maleic anhydride (EPR-g-MA). Due to the molecular structure of the two block copolymers, a coupling agent was not necessary. The block copolymers are semi-crystalline and partially cross-linked in contrast to commonly used amorphous rubbers which are usually uncured. The combination of different analysis methods like atomic force microscopy (AFM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) gave a detailed view in the structure of the blends. Due to the partial cross-linking, the particles of the block copolymers in the blends are not spherical like the ones of ethylene propylene copolymer. The differences in molecular structure, miscibility and grafting of the impact modifiers result in different mechanical properties and different blend morphologies.

  13. Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa

    PubMed Central

    Jacewicz, Agata; Schnell, Robert; Lindqvist, Ylva; Schneider, Gunter

    2016-01-01

    The locus PA4991 in Pseudomonas aeruginosa encodes an open reading frame that has been identified as essential for the virulence and/or survival of this pathogenic organism in the infected host. Here, it is shown that this gene encodes a monomeric FAD-binding protein of molecular mass 42.2 kDa. The structure of PA4991 was determined by a combination of molecular replacement using a search model generated with Rosetta and phase improvement by a low-occupancy heavy-metal derivative. PA4991 belongs to the GR2 family of FAD-dependent oxidoreductases, comprising an FAD-binding domain typical of the glutathione reductase family and a second domain dominated by an eight-stranded mixed β-sheet. Most of the protein–FAD interactions are via the FAD-binding domain, but the isoalloxazine ring is located at the domain interface and interacts with residues from both domains. A comparison with the structurally related glycine oxidase and glycerol-3-phosphate dehydrogenase shows that in spite of very low amino-acid sequence identity (<18%) several active-site residues involved in substrate binding in these enzymes are conserved in PA4991. However, enzymatic assays show that PA4991 does not display amino-acid oxidase or glycerol-3-phosphate dehydrogenase activities, suggesting that it requires different substrates for activity. PMID:26841760

  14. Morphological studies on block copolymer modified PA 6 blends

    SciTech Connect

    Poindl, M. E-mail: christian.bonten@ikt.uni-stuttgart.de; Bonten, C. E-mail: christian.bonten@ikt.uni-stuttgart.de

    2014-05-15

    Recent studies show that compounding polyamide 6 (PA 6) with a PA 6 polyether block copolymers made by reaction injection molding (RIM) or continuous anionic polymerization in a reactive extrusion process (REX) result in blends with high impact strength and high stiffness compared to conventional rubber blends. In this paper, different high impact PA 6 blends were prepared using a twin screw extruder. The different impact modifiers were an ethylene propylene copolymer, a PA PA 6 polyether block copolymer made by reaction injection molding and one made by reactive extrusion. To ensure good particle matrix bonding, the ethylene propylene copolymer was grafted with maleic anhydride (EPR-g-MA). Due to the molecular structure of the two block copolymers, a coupling agent was not necessary. The block copolymers are semi-crystalline and partially cross-linked in contrast to commonly used amorphous rubbers which are usually uncured. The combination of different analysis methods like atomic force microscopy (AFM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) gave a detailed view in the structure of the blends. Due to the partial cross-linking, the particles of the block copolymers in the blends are not spherical like the ones of ethylene propylene copolymer. The differences in molecular structure, miscibility and grafting of the impact modifiers result in different mechanical properties and different blend morphologies.

  15. 48 CFR 1315.209 - Solicitation provisions and contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... COMMERCE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 1315.209 Solicitation provisions and contract clauses. The designee authorized...

  16. 48 CFR 931.205-32 - Pre-contract costs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 931... approved at a management level above the contracting officer. (3) Retroactive precontract...

  17. Commerical Remote Sensing Data Contract

    USGS Publications Warehouse

    ,

    2005-01-01

    The U. S. Geological Survey's (USGS) Commercial Remote Sensing Data Contracts (CRSDCs) provide government agencies with access to a broad range of commercially available remotely sensed airborne and satellite data. These contracts were established to support The National Map partners, other Federal Civilian agency programs, and Department of Defense programs that require data for the United States and its territories. Experience shows that centralized procurement of remotely sensed data leads to considerable cost savings to the Federal government through volume discounts, reduction of redundant contract administrative costs, and avoidance of duplicate purchases. These contracts directly support the President's Commercial Remote Sensing Space Policy, signed in 2003, by providing a centralized mechanism for civil agencies to acquire commercial remote sensing products to support their mission needs in an efficient and coordinated way. CRSDC administration is provided by the USGS Mid-Continent Mapping Center in Rolla, Missouri.

  18. [Patient safety in management contracts].

    PubMed

    Campillo-Artero, C

    2012-01-01

    Patient safety is becoming commonplace in management contracts. Since our experience in patient safety still falls short of other clinical areas, it is advisable to review some of its characteristics in order to improve its inclusion in these contracts. In this paper opinions and recommendations concerning the design and review of contractual clauses on safety are given, as well as reflections drawn from methodological papers and informal opinions of clinicians, who are most familiar with the nuances of safe and unsafe practices. After reviewing some features of these contracts, criteria for prioritizing and including safety objectives and activities in them, and key points for their evaluation are described. The need to replace isolated activities by systemic and multifaceted ones is emphasized. Errors, limitations and improvement opportunities observed when contracts are linked to indicators, information and adverse event reporting systems are analysed. Finally, the influence of the rules of the game, and clinicians behaviour are emphasised.

  19. Roebbelen Contracting Co. Information Sheet

    EPA Pesticide Factsheets

    Roebbelen Contracting Co. (the Company) is located in El Dorado Hills, California. The settlement involves renovation activities conducted at property constructed prior to 1978, located in San Francisco, California.

  20. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  1. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  2. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  3. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  4. 24 CFR 241.605 - Contract requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Purchase and Installation of Energy Conserving Improvements, Solar Energy Systems, and Individual Utility... plus contract. Either form of contract shall include the cost of the energy conserving...

  5. 40 CFR 35.6595 - Contract provisions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Actions Procurement Requirements Under A Cooperative Agreement § 35.6595 Contract provisions. (a) General... regulations pertaining to reporting and patent rights under any contract involving research,...

  6. 48 CFR 1809.670 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Contractor Team Arrangements 1809.670 Contract... solicitations and contracts to clarify a contractor team arrangement where the prime contractor consists of...

  7. 48 CFR 801.602 - Contracting officers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... DEPARTMENT OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and... contracting authority. (7) Manage and enhance career development of the procurement work force. (8)...

  8. Maximising value from PFI contracts.

    PubMed

    Prosser, Karen; Gates, Russell

    2012-05-01

    Against a backdrop where the Coalition Government has said more 'value' needs to be squeezed out of existing healthcare PFI projects, Karen Prosser, head of the health sector team at built asset consultancy, EC Harris, and Russell Gates, one of the company's partners on the same team, set out some of the key elements that NHS Trusts with operational PFI contracts should consider when undertaking a contract savings review.

  9. Contract Incentives for Product Quality

    DTIC Science & Technology

    1980-06-01

    contract administration policy does not seem to be in question. In a sense, the efficiency of the current methodology is under . examination in light...and performance. o Production certificates which attest to the manufacturers’ ability to duplicate the design under an FAA approved quality program...contractor motivational considerations in relation to contracting methodology. The elements of AFSC that were initally under study included the Electronic

  10. Determinants of Service Contract Outcomes

    DTIC Science & Technology

    2011-04-30

    distribution unlimited. Prepared for the Naval Postgraduate School, Monterey, California 93943 NPS-AM-11-C8P08R01-036 Determinants of Service...2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE Determinants of Service Contract Outcomes 5a. CONTRACT NUMBER...specification and measurement of contractor performance problematic. Despite these difficulties, little research has been conducted to examine the determinants

  11. Contractions of affine spherical varieties

    SciTech Connect

    Arzhantsev, I V

    1999-08-31

    The language of filtrations and contractions is used to describe the class of G-varieties obtainable as the total spaces of the construction of contraction applied to affine spherical varieties, which is well-known in invariant theory. These varieties are local models for arbitrary affine G-varieties of complexity 1 with a one-dimensional categorical quotient. As examples, reductive algebraic semigroups and three-dimensional SL{sub 2}-varieties are considered.

  12. [Hyalomatrix PA(®) in skin substitutes. About 10 cases].

    PubMed

    Perrot, P; Dellière, V; Brancati, A; Duteille, F

    2011-04-01

    During the surgical treatment of burns and reconstructive surgery, we can use autografts, allografts, xenografts or dermal substitutes. Acellular dermal substitutes, implantable medical devices of class III are composed mostly of collagen but also, more recently, derivatives of hyaluronic acid (Hyalomatrix PA(®)). Their mechanism of action is based on revascularization and colonization by fibroblasts of the patient. They are then used to screen for delayed epidermal grafting (2-stage procedure for Integra(®), Matriderm(®) 2mm, Renoskin(®), Hyalomatrix PA(®)) or simultaneous (1-time procedure for IntegraSL(®), Matriderm(®) 1mm). We report 10 cases of clinical use of Hyalomatrix PA(®) in the service of burns and plastic surgery of Nantes.

  13. Contract grading in clinical evaluation.

    PubMed

    Schoolcraft, V; Delaney, C

    1982-01-01

    The use of contracts in grading clinical performance has provided faculty with a solution to two important problems. One has been how to ensure that students are graded consistently among the various faculty who are grading the same clinical component of a course. The second has been to increase the opportunity for individualized attention to student learning needs. We have been pleased to see all the faculty members increase their input and involvement in the continuing modifications of the contract. Although we have taken the major responsibility for the semi-annual revisions of the contract, other faculty members have been increasingly more explicit in their evaluations and suggestions as their experience with the contract has expanded. Their confidence in this method of clinical evaluation has increased with each semester of use. We plan to continue in the refinement of the instrument and will develop materials for the use of other faculty groups who are interested in developing similar contracts. We are also designing a survey to attempt to discover how widespread is the use of contract grading in clinical areas.

  14. Shuttle GPS R/PA configuration and specification study

    NASA Technical Reports Server (NTRS)

    Booth, R. W. D.

    1979-01-01

    Changes in the technical specifications for a global positioning system (GPS) receiving system dedicated to space shuttle use are presented. Various hardware functions including acquisition, tracking, and measurement are emphasized. The anti-jam performance of the baseline GPS systems are evaluated. Other topics addressed include: the impact on R/PA design of the use of ground based transmitters; problems involved with the use of single channel tests sets; utility of various R/PA antenna interconnections topologies; the choice of the averaging interval for delta range measurements; and the use of interferometry techniques for the computation of orbiter attitude were undertaken.

  15. Accreditation and implications of clinical postgraduate PA training programs.

    PubMed

    Hussaini, Sobia S; Bushardt, Reamer L; Gonsalves, Wanda C; Hilton, Virginia O; Hornberger, Brad J; Labagnara, Frank A; OʼHara, Kevin M; Sasek, Cody; Smith, Benjamin J; Williams, Jennifer S

    2016-05-01

    No consensus definition exists for postgraduate physician assistant (PA) training. This report from the AAPA Task Force on Accreditation of Postgraduate PA Training Programs describes the types of clinical training programs and their effects on hiring and compensation of PAs. Although completing a postgraduate program appears to have no effect on compensation, PAs who complete these programs may be favored in the hiring process and frequently report greater confidence in their skills. More research is needed and program accreditation is key to monitoring the effectiveness of these programs.

  16. Oxidation of Gas-Phase Protactinium Ions, Pa+ and Pa2+: Formation and Properties of PaO22+(g), Protactinyl

    SciTech Connect

    Santos, M.; de Matos, A. Pires; Marcalo, J.; Gibson, John K; Haire, Richard {Dick} G; Tyagi, R.; Pitzer, R. M.

    2006-01-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N{sub 2}O to the relatively weak CH{sub 2}O - all oxidized Pa{sup +} to PaO{sup +} and PaO{sup +} to PaO{sub 2}{sup +}. On the basis of experimental observations, it was established that D[Pa{sup +}-O] and D[OPa{sup +}-O] {ge} 751 kJ mol{sup -1}. Estimates for D[Pa{sup +}-O], D[OPa{sup +}-O], IE[PaO], and IE[PaO{sub 2}] were also obtained. The seven oxidants reacted with Pa{sup 2+} to produce PaO{sup 2+}, indicating that D[Pa{sup 2+}-O] {ge} 751 kJ mol{sup -1}. A particularly notable finding was the oxidation of PaO{sup 2+} by N{sub 2}O to PaO{sub 2}{sup 2+}, a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO{sub 2}{sup 2+} suggested the protactinyl connectivity, {l_brace}O-Pa-O{r_brace}{sup 2+}. The experimentally determined IE[PaO{sub 2}{sup +}] {approx} 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO{sub 2}{sup +} and PaO{sub 2}{sup 2+}. These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial '6p hole' in the case of protactinyl. It was found that PaO{sub 2}{sup 2+} catalyzes the oxidation of CO by N{sub 2}O - such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO{sub 2}{sup 2+} is capable of activating H{sub 2} to form the stable PaO{sub 2}H{sup 2+} ion.

  17. Apparatus to measure the vapor pressure of slowly decomposing compounds from 1 Pa to 10(5) Pa.

    PubMed

    Berg, Robert F

    2015-11-01

    This article describes an apparatus and method for measuring vapor pressures in the range from 1 Pa to 10(5) Pa. Its three distinctive elements are : (1) the static pressure measurements were made with only a small temperature difference between the vapor and the condensed phase, (2) the sample was degassed in situ, and (3) the temperature range extended up to 200 °C. The apparatus was designed to measure metal-organic precursors, which often are toxic, pyrophoric, or unstable. Vapor pressures are presented for naphthalene, ferrocene, diethyl phthalate, and TEMAH (tetrakisethylmethylaminohafnium). Also presented are data for the temperature-dependent decomposition rate of TEMAH.

  18. ANALYSIS OF ATMOSPHERE DEPOSITION SAMPLES FROM EASTON, PA

    EPA Science Inventory

    The report gives results of an analysis of samples of tenacious atmospheric deposits on exposed surfaces (e.g., automobiles and houses) in an industrial area near Easton, PA. The analysis was made at the request of the State of Pennsylvania. The Pennsylvania Department of Environ...

  19. 78 FR 27025 - Modification of Class B Airspace; Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... modifies the Philadelphia, PA, Class B airspace area to ensure the containment of large turbine-powered... in the Philadelphia terminal area. DATES: Effective Date: 0901 UTC, July 25, 2013. The Director of the Federal Register approves this incorporation by reference action under 1 CFR part 51, subject...

  20. 76 FR 47993 - Safety Zone; Allegheny River; Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... involves establishing, disestablishing, or changing Regulated Navigation Areas and security or safety zones... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Allegheny River; Pittsburgh, PA AGENCY... safety zone on the Allegheny River from mile marker 5.7 to mile marker 5.9 (the parking area on...

  1. 76 FR 28895 - Safety Zone; Ohio River, Sewickley, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ohio River, Sewickley, PA AGENCY: Coast... zone on specified waters of the Ohio River in Sewickley, Pennsylvania. The safety zone is needed to... safety zone on the Ohio River from mile marker 11.7 to mile marker 12.0, extending the entire width...

  2. PA103 Container Pallet MIL-STD-1660 Tests.

    DTIC Science & Technology

    1996-02-01

    Research, Development and Engineering Center (ARDEC) to conduct MIL- STD -1660 tests on PA103 containers unitized on a pallet with dunnage assemblies...supplied by Olin Ordnance. This report contains test results with the palletized unit load tested failing to meet MIL- STD -1660, Design Criteria for

  3. 76 FR 61130 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION.../2011 is hereby amended to include the following areas as adversely affected by the disaster:...

  4. 77 FR 45240 - Establishment of Class E Airspace; Quakertown, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Quakertown, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class E... published in the Federal Register a notice of proposed rulemaking to establish Class E airspace...

  5. 77 FR 16669 - Establishment of Class E Airspace; Bellefonte, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Bellefonte, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class E... Federal Register a notice of proposed rulemaking (NPRM) to establish Class E airspace 700 feet above...

  6. 78 FR 48296 - Amendment of Class E Airspace; Factoryville, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Factoryville, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E... in the Federal Register a notice of proposed rulemaking (NPRM) to amend Class E airspace at...

  7. 75 FR 81469 - Safety Zone; Allegheny River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ...-2010-1082 and are available online by going to http://www.regulations.gov , inserting USCG-2010-1082 in.... 2064; Department of Homeland Security Delegation No. 0170.1. 0 2. Add Sec. 165.T08-1082 to read as follows: Sec. 165.T08-1082 Safety Zone; Allegheny River, Pittsburgh, PA. (a) Location. The following...

  8. Tissue Plasminogen Activator (tPA) Mediates Neurotoxin-Induced Cell Death and Microglial Activation

    DTIC Science & Technology

    2001-07-01

    Alzheimer’s disease and stroke. Tissue plasminogen activator (tPA), a protease converting plasminogen to plasmin, is necessary for neurodegeneration. In mice lacking tPA (tPA-/1), neurons are resistant to neurotoxic death. Delivery of tPA into tpA-/- mice restores susceptibility to neuronal death, indicating that tPA is neurotoxic in the context of excitotoxic injury. Although tPA is synthesized by neurons, the increase in tPA upon injury derives primarily from activated microglia, the immune cells of the brain. Microglia in tPA-/- mice demonstrate reduced activation.

  9. 48 CFR 970.3170 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 970.3170... clause. The contracting officer shall insert the clause at 970.5231-4, Preexisting Conditions, in all management and operating contracts. (a) The contracting officer shall include the clause with its Alternate...

  10. 48 CFR 947.7002 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 947.7002... TRANSPORTATION Foreign Travel 947.7002 Contract clause. When foreign travel may be required under the contract, the contracting officer shall insert the clause at 952.247-70, Foreign Travel....

  11. 48 CFR 13.404 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... AND CONTRACT TYPES SIMPLIFIED ACQUISITION PROCEDURES Fast Payment Procedure 13.404 Contract clause. The contracting officer shall insert the clause at 52.213-1, Fast Payment Procedure, in solicitations and contracts when the conditions in 13.402 are applicable and it is intended that the fast...

  12. 48 CFR 11.703 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DESCRIBING AGENCY NEEDS Variation in Quantity 11.703 Contract clauses. (a) The contracting officer shall insert the clause at 52.211-16, Variation in Quantity, in solicitations and contracts, if authorizing a variation in quantity in fixed-price contracts for supplies or for services that involve the furnishing...

  13. 48 CFR 415.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract format. 415.204 Section 415.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information...

  14. 48 CFR 615.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract format. 615.204 Section 615.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information...

  15. 48 CFR 515.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract format. 515.204 Section 515.204 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and...

  16. 48 CFR 15.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract format. 15.204 Section 15.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information...

  17. 48 CFR 1315.204 - Contract format.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract format. 1315.204 Section 1315.204 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information...

  18. 7 CFR 250.53 - Contract provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS FOR USE IN THE UNITED STATES, ITS... Management Companies § 250.53 Contract provisions. (a) Required contract provisions in fixed-price contracts... recipient agency's fixed-price contract with a food service management company. Such provisions must also...

  19. 48 CFR 546.710 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract clause. 546.710 Section 546.710 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 546.710 Contract clause. The Contracting officer shall insert the clause...

  20. 48 CFR 4.404 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MATTERS Safeguarding Classified Information Within Industry 4.404 Contract clause. (a) The contracting officer shall insert the clause at 52.204-2, Security Requirements, in solicitations and contracts when the contract may require access to classified information, unless the conditions specified...

  1. 7 CFR 1466.21 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS ENVIRONMENTAL QUALITY INCENTIVES PROGRAM Contracts and Payments § 1466.21 Contract requirements. (a) In order for a participant to receive payments.... Technical services may be included in the contract. (b) An EQIP contract will: (1) Identify all...

  2. 7 CFR 1466.21 - Contract requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS ENVIRONMENTAL QUALITY INCENTIVES PROGRAM Contracts and Payments § 1466.21 Contract requirements. (a) In order for a participant to receive payments.... Technical services may be included in the contract. (b) An EQIP contract will: (1) Identify all...

  3. 36 CFR 1008.8 - Government contracts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Government contracts. 1008.8 Section 1008.8 Parks, Forests, and Public Property PRESIDIO TRUST REQUESTS UNDER THE PRIVACY ACT § 1008.8 Government contracts. (a) Required contract provisions. When a contract provides for the operation by or...

  4. 36 CFR 1008.8 - Government contracts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Government contracts. 1008.8 Section 1008.8 Parks, Forests, and Public Property PRESIDIO TRUST REQUESTS UNDER THE PRIVACY ACT § 1008.8 Government contracts. (a) Required contract provisions. When a contract provides for the operation by or...

  5. 36 CFR 1008.8 - Government contracts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Government contracts. 1008.8 Section 1008.8 Parks, Forests, and Public Property PRESIDIO TRUST REQUESTS UNDER THE PRIVACY ACT § 1008.8 Government contracts. (a) Required contract provisions. When a contract provides for the operation by or...

  6. 36 CFR 1008.8 - Government contracts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Government contracts. 1008.8 Section 1008.8 Parks, Forests, and Public Property PRESIDIO TRUST REQUESTS UNDER THE PRIVACY ACT § 1008.8 Government contracts. (a) Required contract provisions. When a contract provides for the operation by or...

  7. 48 CFR 243.205 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses. 243.205 Section 243.205 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205 Contract clauses....

  8. 48 CFR 2943.205 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contract clauses. 2943.205 Section 2943.205 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 2943.205 Contract clauses. HCAs may establish procedures, or office policies,...

  9. 48 CFR 243.205 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contract clauses. 243.205 Section 243.205 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205 Contract clauses....

  10. 48 CFR 2943.205 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Contract clauses. 2943.205 Section 2943.205 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 2943.205 Contract clauses. HCAs may establish procedures, or office policies,...

  11. 48 CFR 1443.205 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1443.205 Section 1443.205 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 1443.205 Contract clauses. BPCs may establish procedures,...

  12. 48 CFR 1443.205 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Contract clauses. 1443.205 Section 1443.205 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 1443.205 Contract clauses. BPCs may establish procedures,...

  13. 29 CFR 95.47 - Contract administration.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Contract administration. 95.47 Section 95.47 Labor Office of... Procurement Standards § 95.47 Contract administration. A system for contract administration shall be maintained to ensure contractor conformance with the terms, conditions and specifications of the contract...

  14. 43 CFR 12.947 - Contract administration.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Contract administration. 12.947 Section 12... Requirements § 12.947 Contract administration. A system for contract administration shall be maintained to ensure contractor conformance with the terms, conditions and specifications of the contract and to...

  15. 12 CFR 239.41 - Employment contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Employment contracts. 239.41 Section 239.41... (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Indemnification; Employment Contracts § 239.41 Employment contracts. (a) General. A mutual holding company may enter into an employment contract with...

  16. 48 CFR 819.7009 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clauses. 819.7009... Acquisition Program 819.7009 Contract clauses. The contracting officer shall insert VAAR clause 852.219-10... Veteran-Owned Small Business Set-Aside in solicitations and contracts for acquisitions under this subpart....

  17. 48 CFR 811.404 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 811.404... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Delivery or Performance Schedules 811.404 Contract clause. When delivery is required by or on a particular date for f.o.b. destination contracts, the contracting...

  18. 7 CFR 457.7 - The contract.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false The contract. 457.7 Section 457.7 Agriculture... AGRICULTURE COMMON CROP INSURANCE REGULATIONS § 457.7 The contract. The insurance contract shall become... insurance on a form prescribed by the Corporation. Changes made in the contract shall not affect...

  19. 48 CFR 903.971 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 903.971... Contract clause. The contracting officer shall insert the clause at 952.203-70, Whistleblower Protection for Contractor Employees, in contracts that involve work to be done on behalf of DOE directly...

  20. 49 CFR 19.47 - Contract administration.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Contract administration. 19.47 Section 19.47... Requirements Procurement Standards § 19.47 Contract administration. A system for contract administration shall... contract and to ensure adequate and timely follow up of all purchases. Recipients shall evaluate...

  1. 48 CFR 11.703 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 11.703... DESCRIBING AGENCY NEEDS Variation in Quantity 11.703 Contract clauses. (a) The contracting officer shall insert the clause at 52.211-16, Variation in Quantity, in solicitations and contracts, if authorizing...

  2. 77 FR 71642 - New International Mail Contract

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ... New International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The... Expedited Package Services 3 contract. This document invites public comments on the request and addresses... Expedited Package Services (GEPS) 3 contract (Contract).\\1\\ The Notice was filed in accordance with 39...

  3. 8 CFR 233.1 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Contracts. 233.1 Section 233.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTRACTS WITH TRANSPORTATION LINES § 233.1 Contracts. The contracts with transportation lines referred to in section 233(c) of the Act may...

  4. 32 CFR 644.49 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Contracts. 644.49 Section 644.49 National... HANDBOOK Appraisal § 644.49 Contracts. (a) Appraisal reports. (1) Within their contract authority, Division and District Engineers may contract with recognized appraisal firms, corporations and individuals...

  5. 48 CFR 846.710 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clauses. 846.710 Section 846.710 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 846.710 Contract clauses. The contracting officer shall insert the clause...

  6. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or...

  7. 2 CFR 200.22 - Contract.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Contract. 200.22 Section 200.22 Grants and... AWARDS Acronyms and Definitions Acronyms § 200.22 Contract. Contract means a legal instrument by which a... entity considers it a contract, when the substance of the transaction meets the definition of a...

  8. 48 CFR 7.404 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 7.404... ACQUISITION PLANNING Equipment Lease or Purchase 7.404 Contract clause. The contracting officer shall insert a... and contracts involving a lease with option to purchase....

  9. 10 CFR 600.147 - Contract administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Contract administration. 600.147 Section 600.147 Energy... Nonprofit Organizations Post-Award Requirements § 600.147 Contract administration. A system for contract... of the contract and to ensure adequate and timely follow up of all purchases. Recipients...

  10. 48 CFR 11.701 - Supply contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Supply contracts. 11.701... DESCRIBING AGENCY NEEDS Variation in Quantity 11.701 Supply contracts. (a) A fixed-price supply contract may... of both; however, contracts for subsistence items may use other applicable terms of variation...

  11. 43 CFR 12.947 - Contract administration.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Contract administration. 12.947 Section 12... Requirements § 12.947 Contract administration. A system for contract administration shall be maintained to ensure contractor conformance with the terms, conditions and specifications of the contract and to...

  12. 48 CFR 846.710 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 846.710 Section 846.710 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 846.710 Contract clauses. The contracting officer shall insert the clause...

  13. 48 CFR 3003.1004 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clauses. 3003.1004... INTEREST Contractor Code of Business Ethics and Conduct 3003.1004 Contract clauses. (a) The contracting... Violations, in solicitations and contracts containing the clause at (FAR) 48 CFR 52.203-13....

  14. 48 CFR 19.1309 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 19.1309... Contract clauses. (a) The contracting officer shall insert the clause 52.219-3, Notice of Total HUBZone Set-Aside or Sole Source Award, in solicitations and contracts for acquisitions that are set aside for,...

  15. 43 CFR 402.9 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Contracts. 402.9 Section 402.9 Public... SALE OF LANDS IN FEDERAL RECLAMATION PROJECTS Public Lands § 402.9 Contracts. A contract in form... the United States by the Commissioner. A copy of the contract shall be furnished to the...

  16. 24 CFR 242.52 - Construction contracts.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract. A contract for the construction or substantial rehabilitation of a hospital shall be entered into by...

  17. 48 CFR 846.710 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clauses. 846.710 Section 846.710 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 846.710 Contract clauses. The contracting officer shall insert the clause...

  18. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or...

  19. 36 CFR 1210.47 - Contract administration.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Contract administration. 1210... § 1210.47 Contract administration. A system for contract administration shall be maintained to ensure contractor conformance with the terms, conditions and specifications of the contract and to ensure...

  20. 48 CFR 871.212 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clauses. 871.212... Rehabilitation and Employment Service 871.212 Contract clauses. Contracting officers must use the following clauses, as appropriate, in solicitations and contracts for vocational rehabilitation and...

  1. 43 CFR 12.948 - Contract provisions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Contract provisions. 12.948 Section 12.948... Requirements § 12.948 Contract provisions. The recipient shall include, in addition to provisions to define a sound and complete agreement, the provisions below in all contracts and subcontracts. (a) Contracts...

  2. 43 CFR 402.9 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Contracts. 402.9 Section 402.9 Public... SALE OF LANDS IN FEDERAL RECLAMATION PROJECTS Public Lands § 402.9 Contracts. A contract in form... the United States by the Commissioner. A copy of the contract shall be furnished to the...

  3. 43 CFR 12.948 - Contract provisions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Contract provisions. 12.948 Section 12.948... Requirements § 12.948 Contract provisions. The recipient shall include, in addition to provisions to define a sound and complete agreement, the provisions below in all contracts and subcontracts. (a) Contracts...

  4. 7 CFR 1215.41 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Contracts. 1215.41 Section 1215.41 Agriculture..., Consumer Information, and Industry Information § 1215.41 Contracts. The Board shall not contract with any... and approved by the Secretary. Any contract or agreement shall provide that: (a) The contractor...

  5. 36 CFR 1008.8 - Government contracts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Government contracts. 1008.8... Government contracts. (a) Required contract provisions. When a contract provides for the operation by or on behalf of the Presidio Trust of a system of records to accomplish a Presidio Trust function, the...

  6. 7 CFR 1463.109 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Contracts. 1463.109 Section 1463.109 Agriculture... Payment Program § 1463.109 Contracts. (a) CCC will enter into a contract with eligible tobacco quota holders and producers. To the extent a person has filed such a contract with CCC, but a...

  7. 32 CFR 644.49 - Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Contracts. 644.49 Section 644.49 National Defense... Appraisal § 644.49 Contracts. (a) Appraisal reports. (1) Within their contract authority, Division and District Engineers may contract with recognized appraisal firms, corporations and individuals for...

  8. 8 CFR 233.1 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Contracts. 233.1 Section 233.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTRACTS WITH TRANSPORTATION LINES § 233.1 Contracts. The contracts with transportation lines referred to in section 233(c) of the Act may...

  9. 48 CFR 745.106 - Contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clauses. 745.106 Section 745.106 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 745.106 Contract clauses. (a) The contracting officer shall insert...

  10. 7 CFR 1412.63 - Contract liability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Contract liability. 1412.63 Section 1412.63... CROP REVENUE ELECTION PROGRAM FOR THE 2008 AND SUBSEQUENT CROP YEARS Contract Violations and Reduction in Payments § 1412.63 Contract liability. All signatories to a DCP or ACRE program contract...

  11. 48 CFR 19.1407 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 19.1407... Contract clauses. The contracting officer shall insert the clause 52.219-27, Notice of Total Service-Disabled Veteran-Owned Small Business Set-Aside, in solicitations and contracts for acquisitions under...

  12. 48 CFR 871.212 - Contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clauses. 871.212... Rehabilitation and Employment Service 871.212 Contract clauses. Contracting officers must use the following clauses, as appropriate, in solicitations and contracts for vocational rehabilitation and...

  13. 48 CFR 904.7201 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clause. 904.7201... MATTERS Public Affairs 904.7201 Contract clause. The contracting officer shall insert the clause at 952.204-75, Public Affairs, in solicitations and contracts that require the contractor to...

  14. 7 CFR 407.7 - The contract.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false The contract. 407.7 Section 407.7 Agriculture... AGRICULTURE AREA RISK PROTECTION INSURANCE REGULATIONS § 407.7 The contract. (a) The insurance contract shall... application for insurance on a form prescribed or approved by FCIC. (b) The contract shall consist of...

  15. 48 CFR 4.404 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 4.404... MATTERS Safeguarding Classified Information Within Industry 4.404 Contract clause. (a) The contracting officer shall insert the clause at 52.204-2, Security Requirements, in solicitations and contracts...

  16. 7 CFR 550.49 - Contract administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Contract administration. 550.49 Section 550.49... Agreements Procurement Standards § 550.49 Contract administration. A system for contract administration shall... contract and to ensure adequate and timely followup of all purchases. Recipients shall evaluate...

  17. 10 CFR 436.38 - Terminating contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Terminating contracts. 436.38 Section 436.38 Energy... Procedures for Energy Savings Performance Contracting § 436.38 Terminating contracts. (a) Except as otherwise provided by this subpart, termination of energy savings performance contracts shall be subject to...

  18. 48 CFR 903.971 - Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Contract clause. 903.971... Contract clause. The contracting officer shall insert the clause at 952.203-70, Whistleblower Protection for Contractor Employees, in contracts that involve work to be done on behalf of DOE directly...

  19. 48 CFR 803.7001 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 803.7001... Practices 803.7001 Contract clause. The contracting officer shall insert the clause at 852.203-71, Display of Department of Veterans Affairs Hotline poster, in solicitations and contracts expected to equal...

  20. 78 FR 72572 - Operational Contract Support

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... of the Secretary 32 CFR Part 158 RIN 0790-AI48 Operational Contract Support AGENCY: Department of... provides procedures for operational contract support (OCS), including OCS program management, contract... INFORMATION CONTACT: Shanna Poole, Director, Operational Contract Support Policy, Office of the...

  1. 7 CFR 1463.109 - Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Contracts. 1463.109 Section 1463.109 Agriculture... Payment Program § 1463.109 Contracts. (a) CCC will enter into a contract with eligible tobacco quota holders and producers. To the extent a person has filed such a contract with CCC, but a...

  2. 25 CFR 700.89 - Relocation contract.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Relocation contract. 700.89 Section 700.89 Indians THE... Policies and Instructions Definitions § 700.89 Relocation contract. The Relocation Contract is that contract signed by the head of household in which he/she agrees to purchase an existing house or...

  3. 77 FR 5280 - Service Contracts Inventory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... COMMISSION Service Contracts Inventory AGENCY: Nuclear Regulatory Commission. ACTION: Notice of availability... Contracts for Services for Fiscal Year (FY) 2011. The inventory includes service contract actions over $25... . The Inventory of Contracts for Services for FY 2011 can be accessed under ADAMS accession...

  4. 7 CFR 763.19 - Contract modification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Contract modification. 763.19 Section 763.19... AGRICULTURE SPECIAL PROGRAMS LAND CONTRACT GUARANTEE PROGRAM § 763.19 Contract modification. (a) The seller and buyer may modify the land contract to lower the interest rate and corresponding amortized...

  5. 25 CFR 700.89 - Relocation contract.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Relocation contract. 700.89 Section 700.89 Indians THE... Policies and Instructions Definitions § 700.89 Relocation contract. The Relocation Contract is that contract signed by the head of household in which he/she agrees to purchase an existing house or...

  6. 43 CFR 402.9 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Contracts. 402.9 Section 402.9 Public Lands... LANDS IN FEDERAL RECLAMATION PROJECTS Public Lands § 402.9 Contracts. A contract in form approved by the... by the Commissioner. A copy of the contract shall be furnished to the appropriate land office of...

  7. 7 CFR 1215.41 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Contracts. 1215.41 Section 1215.41 Agriculture..., Consumer Information, and Industry Information § 1215.41 Contracts. The Board shall not contract with any... and approved by the Secretary. Any contract or agreement shall provide that: (a) The contractor...

  8. 77 FR 54937 - International Mail Postal Contract

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... COMMISSION International Mail Postal Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY... Business Reply Service Contract 3. It seeks inclusion of the new contract within an existing product... public that the Postal Service has filed a notice stating that it (1) has entered into a new contract...

  9. 43 CFR 12.948 - Contract provisions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Contract provisions. 12.948 Section 12.948... Requirements § 12.948 Contract provisions. The recipient shall include, in addition to provisions to define a sound and complete agreement, the provisions below in all contracts and subcontracts. (a) Contracts...

  10. 24 CFR 402.3 - Contract provisions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Contract provisions. 402.3 Section... URBAN DEVELOPMENT SECTION 8 PROJECT-BASED CONTRACT RENEWAL UNDER SECTION 524 OF MAHRA § 402.3 Contract provisions. The renewal HAP contract shall be construed and administered in accordance with all...

  11. 48 CFR 53.111 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contract clause. 53.111... AND FORMS FORMS General 53.111 Contract clause. Contracting officers shall insert the clause at 52.253-1, Computer Generated Forms, in solicitations and contracts that require the contractor to...

  12. 48 CFR 12.207 - Contract type.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract type. 12.207... ACQUISITION OF COMMERCIAL ITEMS Special Requirements for the Acquisition of Commercial Items 12.207 Contract... contracts or fixed-price contracts with economic price adjustment for the acquisition of commercial...

  13. 48 CFR 3402.201 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clause. 3402.201... GENERAL DEFINITIONS OF WORDS AND TERMS Definitions Clause 3402.201 Contract clause. The contracting... and contracts in which the clause at FAR 52.202-1 is required....

  14. 48 CFR 12.303 - Contract format.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract format. 12.303... ACQUISITION OF COMMERCIAL ITEMS Solicitation Provisions and Contract Clauses for the Acquisition of Commercial Items 12.303 Contract format. Solicitations and contracts for the acquisition of commercial...

  15. 7 CFR 1463.109 - Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Contracts. 1463.109 Section 1463.109 Agriculture... Payment Program § 1463.109 Contracts. (a) CCC will enter into a contract with eligible tobacco quota holders and producers. To the extent a person has filed such a contract with CCC, but a...

  16. 48 CFR 803.7001 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 803.7001... Practices 803.7001 Contract clause. The contracting officer shall insert the clause at 852.203-71, Display of Department of Veterans Affairs Hotline poster, in solicitations and contracts expected to equal...

  17. 48 CFR 2943.205 - Contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clauses. 2943.205 Section 2943.205 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 2943.205 Contract clauses. HCAs may establish procedures, or office policies,...

  18. 32 CFR 169a.10 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Contracts. 169a.10 Section 169a.10 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.10 Contracts. When contract cost becomes unreasonable or...

  19. 48 CFR 811.404 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.404... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Delivery or Performance Schedules 811.404 Contract clause. When delivery is required by or on a particular date for f.o.b. destination contracts, the contracting...

  20. 48 CFR 22.610 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 22.610... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Walsh-Healey Public Contracts Act 22.610 Contract clause. The contracting officer shall insert the clause at 52.222-20, Walsh-Healey...

  1. 48 CFR 904.7201 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 904.7201... MATTERS Public Affairs 904.7201 Contract clause. The contracting officer shall insert the clause at 952.204-75, Public Affairs, in solicitations and contracts that require the contractor to...

  2. 48 CFR 903.971 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 903.971... Contract clause. The contracting officer shall insert the clause at 952.203-70, Whistleblower Protection for Contractor Employees, in contracts that involve work to be done on behalf of DOE directly...

  3. 7 CFR 1466.21 - Contract requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Contract requirements. 1466.21 Section 1466.21... Contracts and Payments § 1466.21 Contract requirements. (a) In order for a participant to receive payments, the participant must enter into a contract agreeing to implement one or more conservation...

  4. 48 CFR 819.7009 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 819.7009... Acquisition Program 819.7009 Contract clauses. The contracting officer shall insert VAAR clause 852.219-10... Veteran-Owned Small Business Set-Aside in solicitations and contracts for acquisitions under this subpart....

  5. 7 CFR 1215.41 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Contracts. 1215.41 Section 1215.41 Agriculture..., Consumer Information, and Industry Information § 1215.41 Contracts. The Board shall not contract with any... and approved by the Secretary. Any contract or agreement shall provide that: (a) The contractor...

  6. 32 CFR 644.49 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Contracts. 644.49 Section 644.49 National... HANDBOOK Appraisal § 644.49 Contracts. (a) Appraisal reports. (1) Within their contract authority, Division and District Engineers may contract with recognized appraisal firms, corporations and individuals...

  7. 7 CFR 1450.211 - BCAP contract.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false BCAP contract. 1450.211 Section 1450.211 Agriculture... Payments and Annual Payments § 1450.211 BCAP contract. (a) In order to enroll land in BCAP, the participant must enter into a contract with CCC. (b) The contract is comprised of: (1) The terms and conditions...

  8. 48 CFR 22.1705 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 22.1705... Contract clause. (a) Insert the clause at 52.222-50, Combating Trafficking in Persons, in all solicitations and contracts. (b) Use the basic clause with its Alternate I when the contract will be...

  9. 43 CFR 12.947 - Contract administration.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Contract administration. 12.947 Section 12... Requirements § 12.947 Contract administration. A system for contract administration shall be maintained to ensure contractor conformance with the terms, conditions and specifications of the contract and to...

  10. 29 CFR 4.190 - Contract cancellation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Contract cancellation. 4.190 Section 4.190 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Enforcement § 4.190 Contract cancellation. (a) As provided in section 3 of the Act, where a violation is found of any contract...

  11. 48 CFR 745.106 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 745.106 Section 745.106 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 745.106 Contract clauses. (a) The contracting officer shall insert...

  12. 10 CFR 600.148 - Contract provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Contract provisions. 600.148 Section 600.148 Energy... Nonprofit Organizations Post-Award Requirements § 600.148 Contract provisions. The recipient shall include... contracts. The following provisions shall also be applied to subcontracts. (a) Contracts in excess of...

  13. 48 CFR 13.404 - Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 13.404 Section 13.404 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SIMPLIFIED ACQUISITION PROCEDURES Fast Payment Procedure 13.404 Contract...

  14. 7 CFR 1215.41 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Contracts. 1215.41 Section 1215.41 Agriculture..., Consumer Information, and Industry Information § 1215.41 Contracts. The Board shall not contract with any... and approved by the Secretary. Any contract or agreement shall provide that: (a) The contractor...

  15. 48 CFR 3.1004 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 3.1004... Contract clauses. (a) Insert the clause at FAR 52.203-13, Contractor Code of Business Ethics and Conduct, in solicitations and contracts if the value of the contract is expected to exceed $5,000,000 and...

  16. 48 CFR 11.503 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clauses. 11.503... DESCRIBING AGENCY NEEDS Liquidated Damages 11.503 Contract clauses. (a) Use the clause at 52.211-11... contracts for supplies, services, or research and development when the contracting officer determines...

  17. 48 CFR 904.7201 - Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Contract clause. 904.7201... MATTERS Public Affairs 904.7201 Contract clause. The contracting officer shall insert the clause at 952.204-75, Public Affairs, in solicitations and contracts that require the contractor to...

  18. 8 CFR 233.1 - Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Contracts. 233.1 Section 233.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTRACTS WITH TRANSPORTATION LINES § 233.1 Contracts. The contracts with transportation lines referred to in section 233(c) of the Act may...

  19. 48 CFR 3023.303 - Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract clause. 3023.303... Material Safety Data 3023.303 Contract clause. The contracting officer shall insert the clause at (HSAR) 48... solicitations and contracts involving the removal or disposal of hazardous waste material....

  20. 7 CFR 1463.109 - Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Contracts. 1463.109 Section 1463.109 Agriculture... Payment Program § 1463.109 Contracts. (a) CCC will enter into a contract with eligible tobacco quota holders and producers. To the extent a person has filed such a contract with CCC, but a...