Science.gov

Sample records for 50-year return period

  1. 50-year return-period wet-snow load estimation based on weather station data for overhead line design in France

    NASA Astrophysics Data System (ADS)

    Ducloux, H.; Nygaard, B. E.

    2014-11-01

    Historically, as far as wet-snow loads were concerned, overhead line design was often based on experience or long-term applications with positive results. New standard like CENELEC EN 580341-1 (2012) take into account characteristic loads, i.e. 50-year return-period loads, for the overhead line design. This article proposes a method to estimate characteristic wet-snow loads based on meteorological data recorded at weather stations. The model used to calculate those loads is mainly inspired by a recent article written by Nygaard et al. (2013a) in which a new parameterization is proposed for the classical cylindrical wet-snow accretion model, as described in ISO 12494 standard (2001), annex C. After a complete description of the model and its parameterization adapted to French wet-snow events, the statistical issues are examined. Then, the model is used with the meteorological data of 87 weather stations in order to calculate wet-snow loads whose relevance has been positively tested according to real damages recorded in a complete wet-snow event database. At last, the characteristic loads of those 87 stations have been determined according to all the loads generated by the model and processed by a peak-over-threshold (POT) method. A practical method to determine the 90% confidence intervals of those characteristic values is given. As it is demonstrated that there is only one value of the ice class (IC) masses proposed by ISO 12494 in each confidence interval, characteristic loads can be easily expressed in terms of ICs. That method shows that ICs ranging from R1 (0.5 kg m-1) to R5 (5 kg m-1) could be used for overhead line design in France.

  2. Influence of climatic conditions on production of Stipa-Bouteloua prairie over a 50-year period

    SciTech Connect

    Smoliak, S.

    1986-03-01

    Range forage yields obtained over a 50-year period at the Research Substation near Manyberries in southeastern Alberta were analyzed in relation to several climatic factors. The basic variables were precipitation, pan evaporation, temperature, hours of sunlight, and wind velocity. The precipitation from April through July was highly correlated with range forage production and this relationship could be utilized to predict the annual forage production by 1 August each year. A slightly better correlation was obtained when range forage production was related to the total of the previous September plus the current April through July precipitation. Pan evaporation totals, mean temperature, and hours of sunlight were negatively correlated with forage production, while wind velocity during the growing season showed a low relationship to forage production. Stepwise regression analysis showed that the inclusion of May and June mean temperatures with June and July precipitation accounted for 63% of the variation in range forage production. The predicted forage yield would be useful in making management decisions or adjustments, especially during drought periods, while the long-term forage yield data can be utilized in range forage models or in validating their effectiveness.

  3. Long-term variation analysis of a tropical river's annual streamflow regime over a 50-year period

    NASA Astrophysics Data System (ADS)

    Seyam, Mohammed; Othman, Faridah

    2015-07-01

    Studying the long-term changes of streamflow is an important tool for enhancing water resource and river system planning, design, and management. The aim of this work is to identify the long-term variations in annual streamflow regime over a 50-year period from 1961 to 2010 in the Selangor River, which is one of the main tropical rivers in Malaysia. Initially, the data underwent preliminary independence, normality, and homogeneity testing using the Pearson correlation coefficient and Shapiro-Wilk and Pettitt's tests, respectively. The work includes a study and analysis of the changes through nine variables describing the annual streamflow and variations in the yearly duration of high and low streamflows. The analyses were conducted via two time scales: yearly and sub-periodic. The sub-periods were obtained by segmenting the 50 years into seven sub-periods by two techniques, namely the change-point test and direct method. Even though analysis revealed nearly negligible changes in mean annual flow over the study period, the maximum annual flow generally increased while the minimum annual flow significantly decreased with respect to time. It was also observed that the variables describing the dispersion in streamflow continually increased with respect to time. An obvious increase was detected in the yearly duration of danger level of streamflow, a slight increase was noted in the yearly duration of warning and alert levels, and a slight decrease in the yearly duration of low streamflow was found. The perceived changes validate the existence of long-term changes in annual streamflow regime, which increase the probability of floods and droughts occurring in future. In light of the results, attention should be drawn to developing water resource management and flood protection plans in order to avert the harmful effects potentially resulting from the expected changes in annual streamflow regime.

  4. Reliability, return periods, and risk under nonstationarity

    NASA Astrophysics Data System (ADS)

    Read, Laura K.; Vogel, Richard M.

    2015-08-01

    Water resources design has widely used the average return period as a concept to inform management and communication of the risk of experiencing an exceedance event within a planning horizon. Even though nonstationarity is often apparent, in practice hydrologic design often mistakenly assumes that the probability of exceedance, p, is constant from year to year which leads to an average return period To equal to 1/p; this expression is far more complex under nonstationarity. Even for stationary processes, the common application of an average return period is problematic: it does not account for planning horizon, is an average value that may not be representative of the time to the next flood, and is generally not applied in other areas of water planning. We combine existing theoretical and empirical results from the literature to provide the first general, comprehensive description of the probabilistic behavior of the return period and reliability under nonstationarity. We show that under nonstationarity, the underlying distribution of the return period exhibits a more complex shape than the exponential distribution under stationary conditions. Using a nonstationary lognormal model, we document the increased complexity and challenges associated with planning for future flood events over a planning horizon. We compare application of the average return period with the more common concept of reliability and recommend replacing the average return period with reliability as a more practical way to communicate event likelihood in both stationary and nonstationary contexts.

  5. Return periods of global climate fluctuations and the pause

    NASA Astrophysics Data System (ADS)

    Lovejoy, S.

    2014-07-01

    An approach complementary to General Circulation Models (GCMs), using the anthropogenic CO2 radiative forcing as a linear surrogate for all anthropogenic forcings [Lovejoy], was recently developed for quantifying human impacts. Using preindustrial multiproxy series and scaling arguments, the probabilities of natural fluctuations at time lags up to 125 years were determined. The hypothesis that the industrial epoch warming was a giant natural fluctuation was rejected with 99.9% confidence. In this paper, this method is extended to the determination of event return times. Over the period 1880-2013, the largest 32 year event is expected to be 0.47 K, effectively explaining the postwar cooling (amplitude 0.42-0.47 K). Similarly, the "pause" since 1998 (0.28-0.37 K) has a return period of 20-50 years (not so unusual). It is nearly cancelled by the pre-pause warming event (1992-1998, return period 30-40 years); the pause is no more than natural variability.

  6. A Perspective on the Intended Science Curriculum in Iceland and its `Transformation' over a Period of 50 Years

    NASA Astrophysics Data System (ADS)

    Thorolfsson, Meyvant; Finnbogason, Gunnar E.; Macdonald, Allyson

    2012-11-01

    In recent decades, a consensus has emerged among educators and scientists that all compulsory school students need good science education. The debate about its purpose and nature as a school subject in an emerging information society has not been as conclusive. To further understand this, it helps to examine how the science curriculum has transformed and what forces have shaped it as a core curricular area over time. This article sheds light on the transformation of the science curriculum for compulsory schools in Iceland in force from 1960 to 2010. Using criteria based on curriculum ideologies regarding the function of learners, instructors and subject matter in the learning process and the orientation of content and product versus process and development, it offers findings from content analysis of the intended science curriculum. The official curriculum was studied and conceptualised as it has evolved over time. The curriculum developers appear to have been striving for a compromise between conflicting views, resulting in what the authors of this article conceive as a 'kaleidoscopic quilt' of ideas over the period studied.

  7. An analysis of the sequence variability of meningococcal fHbp, NadA and NHBA over a 50-year period in the Netherlands.

    PubMed

    Bambini, Stefania; Piet, Jurgen; Muzzi, Alessandro; Keijzers, Wendy; Comandi, Sara; De Tora, Lisa; Pizza, Mariagrazia; Rappuoli, Rino; van de Beek, Diederik; van der Ende, Arie; Comanducci, Maurizio

    2013-01-01

    Studies of meningococcal evolution and genetic population structure, including the long-term stability of non-random associations between variants of surface proteins, are essential for vaccine development. We analyzed the sequence variability of factor H-binding protein (fHbp), Neisserial Heparin-Binding Antigen (NHBA) and Neisseria adhesin A (NadA), three major antigens in the multicomponent meningococcal serogroup B vaccine 4CMenB. A panel of invasive isolates collected in the Netherlands over a period of 50 years was used. To our knowledge, this strain collection covers the longest time period of any collection available worldwide. Long-term persistence of several antigen sub/variants and of non-overlapping antigen sub/variant combinations was observed. Our data suggest that certain antigen sub/variants including those used in 4CMenB are conserved over time and promoted by selection. PMID:23717687

  8. ISME Celebrates 50 Years

    ERIC Educational Resources Information Center

    Teaching Music, 2004

    2004-01-01

    When members of the International Society for Music Education (ISME) met in Tenerife, Canary Islands, Spain in July for the 26th ISME World Conference, the gathering was an opportunity to share music from around the world, and to attend music education workshops. It was also an opportunity for its members to look back on the rich 50-year history…

  9. 50 years of JETP Letters

    NASA Astrophysics Data System (ADS)

    Pastukhov, V. P.

    2015-04-01

    This paper briefly traces the 50-year history of the journal Pis'ma v Zhurnal Eksperimental'noi i Teoreticheskoi Fiziki (JETP Letters), whose first issue was published on 1 April 1965. The journal is intended for a wide circle of physicists-readers as a fast publication channel for short communications on new results from research of the highest significance and highest priority in all areas of experimental and theoretical physics. Today, the journal celebrates numerous important contributions to the development of physics both in Russia and worldwide. Over a historically short period, JETP Letters developed into a highly authoritative and influential source for physicists engaged in a wide range of fields. Due to the wise and well-timed editorial policy, the journal continues to retain its leadership position, despite the difficulties the entire science periodical literature - and indeed the whole of science - is currently experiencing in Russia.

  10. One hundred years of return period: Strengths and limitations

    NASA Astrophysics Data System (ADS)

    Volpi, E.; Fiori, A.; Grimaldi, S.; Lombardo, F.; Koutsoyiannis, D.

    2015-10-01

    One hundred years from its original definition by Fuller, the probabilistic concept of return period is widely used in hydrology as well as in other disciplines of geosciences to give an indication on critical event rareness. This concept gains its popularity, especially in engineering practice for design and risk assessment, due to its ease of use and understanding; however, return period relies on some basic assumptions that should be satisfied for a correct application of this statistical tool. Indeed, conventional frequency analysis in hydrology is performed by assuming as necessary conditions that extreme events arise from a stationary distribution and are independent of one another. The main objective of this paper is to investigate the properties of return period when the independence condition is omitted; hence, we explore how the different definitions of return period available in literature affect results of frequency analysis for processes correlated in time. We demonstrate that, for stationary processes, the independence condition is not necessary in order to apply the classical equation of return period (i.e., the inverse of exceedance probability). On the other hand, we show that the time-correlation structure of hydrological processes modifies the shape of the distribution function of which the return period represents the first moment. This implies that, in the context of time-dependent processes, the return period might not represent an exhaustive measure of the probability of failure, and that its blind application could lead to misleading results. To overcome this problem, we introduce the concept of Equivalent Return Period, which controls the probability of failure still preserving the virtue of effectively communicating the event rareness.

  11. An update on multivariate return periods in hydrology

    NASA Astrophysics Data System (ADS)

    Gräler, Benedikt; Petroselli, Andrea; Grimaldi, Salvatore; De Baets, Bernard; Verhoest, Niko

    2016-05-01

    Many hydrological studies are devoted to the identification of events that are expected to occur on average within a certain time span. While this topic is well established in the univariate case, recent advances focus on a multivariate characterization of events based on copulas. Following a previous study, we show how the definition of the survival Kendall return period fits into the set of multivariate return periods.Moreover, we preliminary investigate the ability of the multivariate return period definitions to select maximal events from a time series. Starting from a rich simulated data set, we show how similar the selection of events from a data set is. It can be deduced from the study and theoretically underpinned that the strength of correlation in the sample influences the differences between the selection of maximal events.

  12. Determining the Return Period of Storm Surge Events in the Philippines

    NASA Astrophysics Data System (ADS)

    Santiago, Joy; Suarez, John Kenneth; Lapidez, John Phillip; Mendoza, Jerico; Caro, Carl Vincent; Tablazon, Judd; Ladiero, Christine; Mahar Francisco Lagmay, Alfredo

    2015-04-01

    The devastating damages generated by the Tropical Cyclone Haiyan storm surges in Eastern Samar, Philippines prompted the Department of Science and Technology-Project NOAH (Nationwide Operational Assessment of Hazards) to calculate the return period and storm surge exceedance probability of these events. The recurrence interval or the period of return of a storm surge event is the estimated likelihood that that event would occur again. Return periods are measured through historical data denoting the interval of recurrence in average over a period of time. The exceedance probability however, is a graphical representation that describes the probability that some various levels of loss will be exceeded over a future time period or will be surpassed over a given time. DOST-Project NOAH simulates storm surge height time series using JMA storm surge model which is a numerical model based on shallow water equations. To determine the period of recurrence of storm surges with this type of intensity, the agency intends to compute the estimation of storm surge heights generated by tropical cyclones for 2-year, 5-year, 10-year, 25-year, 50-year and 100-year return periods for the Philippine coast. The storm surge time series generated from JMA combined with WXTide simulation, a software containing archives/catalogues of world-wide astronomical tides, and 5-meter resolution DEM were used as input parameters for the inundation model, which shows probable extent of flooding at a specific storm surge return period. Flo-2D two-dimensional flood routing model, a GIS integrated software tool that facilitates the creation of the flood model grid system, was used for flood hazard model. It is a simple volume conservation model composed of processor program that facilitate graphical editing and mapping of flooding details which uses continuity equation and the dynamic wave momentum equations. The measurements of storm surge return period and probable extent of coastal flooding in the

  13. The 2011 Thailand flood: climate causes and return periods

    NASA Astrophysics Data System (ADS)

    Gale, Emma; Saunders, Mark

    2013-04-01

    Thailand is one of the most developed and wealthiest countries in Southeast Asia. However, its tropical location and the influence of seasonal monsoon rains and local topography make it prone to floods. The Thailand floods in 2011 were especially severe causing estimated losses of US 30 billion (economic) and US 12 billion (insured) (Swiss Re, 2012). This insured loss ranks easily as the highest ever worldwide from a freshwater flood disaster (Swiss Re, 2012). We review the nature, impacts and historical ranking of the 2011 Thailand flood, and then discuss the climate causes for the exceptional rainfall which triggered the flood - annual rainfall in 2011 was the highest in Thailand's 61-year precipitation record (Thai Meteorological Department, 2011). Thai precipitation data from 100 stations for the period 1992-2011, NCEP/NCAR mean sea level pressure (MSLP) data and best-track data from the Joint Typhoon Warning Center for the period 1992-2011 are used in this study. We find that the floods were caused by a combination of a strong Southeast Asian summer monsoon that brought high rainfall across the country between May and October, and by the remnants of four tropical storms that brought high rainfall to northern Thailand between June and October. During the monsoon season the Southern Oscillation was moderately positive and, as a result, likely contributed to the high monsoonal rains. We estimate the return periods for the 2011 Thai rains and compare these to satellite-derived return periods for 2011 Thai river flow. The rainfall return period varies from 8-20 years in the north and south of the country to 1-8 years in the east and centre of Thailand. Satellite-derived river flows at two locations on the Chao Phraya River suggest a return period of 10-20 years. The return period is also estimated using historical flood records (Brakenridge, 2012) which suggest a return period of 5-6 years. A 'consensus' return period for the 2011 Thai flood is estimated to be 10

  14. Evaluation of the Precision of Return Period calculated by GSMaP data

    NASA Astrophysics Data System (ADS)

    Taguchi, R.; Seto, S.

    2015-12-01

    A heavy rain by Typhoon1326 was generated over IzuOshima Island on October 17, 2013. As for nine rain gauges in IzuOshima Island, precipitation amount exceeded the threshold of the special warning for 3 hours. However, the special warning was not announced because it did not satisfy "heavy rainfall over the threshold value is recorded at more than 10 points". It is suggested that the special warning at islands is hard to be announced. Therefore we propose to apply GSMaP which can be used not only over land but over ocean for the special warning. We calculated the threshold of the special warning by using GSMaP data and compared it with that by Japan Meteorological Agency (JMA). GSMaP has the following characteristics. ・GSMaP estimates precipitation every hour with the resolution of 0.1 degrees grid. ・GSMaP is not good at orographic rainfall , but it is good at rainfall over the Tropics and ocean. ・GSMaP covers almost all over the world between 60 degrees north and south. The standard of JMA is as follows. ・The amount of rainfall in 3 hours exceed 50-year value at 10 points in the spread of the prefecture degree. ・The amount of rainfall in 48 hours exceed 50-year value at 50 points in the spread of the prefecture degree. We calculated the amount of 50-year rainfall by GSMaP and compared it with the threshold value of JMA. But there are only 9-year GSMaP data used in this study. The number of sample is too little to calculate return period. We have also added the data at the surrounding grids. We tried to increase the number of samples in this way. GSMaP has several problems. One of that's GSMaP mistakes snow for rainfall. So we grasped the characteristics of such case. And we made the mask to take such case. When we calculate with the mask, the abnormal values has decreased. We improved stability of calculation return period with these ways.

  15. Extreme Volcanic Eruptions: return periods, impact and implications (Invited)

    NASA Astrophysics Data System (ADS)

    Sparks, R. S.

    2010-12-01

    In the very short history of civilisation, a few thousand years, there have been comparably few very large volcanic events which global effects. Such events include very large lavas flow eruptions, such as Laki (Iceland) in 1783 and major caldera-forming explosive eruptions, such as Tambora in 1815 and Tianchi around 930 AD. Much larger magnitude eruptions have happened regularly when time scales of millions of years are considered. The modern globalised world is arguably uniquely vulnerable to very large volcanic events, making the study of their return periods, possible environmental effects and consequences a key goal of volcanology. A database of Quaternary large magnitude explosive eruptions (M ≥ 4) is under development as part of the VOGRIPA project on global volcanic hazards and risk. The database, currently consisting of 1929 entries from 481 Quaternary volcanoes, can be applied to constraining the magnitude-frequency relationship of global and regional explosive volcanism. Application of extreme value statistics to a Holocene subset of data, corrected for under-recording, enables construction of a magnitude-frequency relationship for global volcanism. Return periods based on maximum likelihood statistical analysis are 7.9 years for M ≥ 4, 35 years for M ≥ 5, and 370 years for M ≥ 7.0 with uncertainty increasing with magnitude. The return periods depend on the threshold chosen between the main part of the distribution and the extreme value tail and the results cited here are for a threshold of M = 4. For the largest magnitude eruptions (M > 7.5) the Holocene period is too short to obtain a meaningful result. The effects if an eruption like Tambora 1815 (M ~ 6.9) in the modern world is likely to be dramatic as the populations in SE Asia are now well over 20 time greater and the socio-economic vulnerability has also increased. Effects will include atmospheric pollution lasting a few years, major global climate perturbations and regional disruption

  16. Discovering Astronomy 50 Years Ago

    NASA Astrophysics Data System (ADS)

    Mouradian, Z.

    2008-09-01

    Three years after graduating in astronomy from Bucharest University, I was finally recruited by the Bucharest Observatory to participate in the International Geophysical Year. I joined the Observatory as the third fellow of the Solar Department. There, I became an expert in satellite affairs thanks to a TV broadcast shot. I was in charge of adjusting the newly received solar instruments and contributed to the international campaign, including the solar patrol. Since it was absolutely impossible for me to start a thesis at that time, I moved to France and started a new career in the Solar Department of Paris-Meudon Observatory. My experience at the Bucharest Observatory was fundamental to the rest of my work over the following 50 years. My cooperation with the Bucharest Observatory increased after 1992 and still continues today.

  17. 50 years of fusion research

    NASA Astrophysics Data System (ADS)

    Meade, Dale

    2010-01-01

    Fusion energy research began in the early 1950s as scientists worked to harness the awesome power of the atom for peaceful purposes. There was early optimism for a quick solution for fusion energy as there had been for fission. However, this was soon tempered by reality as the difficulty of producing and confining fusion fuel at temperatures of 100 million °C in the laboratory was appreciated. Fusion research has followed two main paths—inertial confinement fusion and magnetic confinement fusion. Over the past 50 years, there has been remarkable progress with both approaches, and now each has a solid technical foundation that has led to the construction of major facilities that are aimed at demonstrating fusion energy producing plasmas.

  18. The return periods and risk assessment of severe dust storms in Inner Mongolia with consideration of the main contributing factors.

    PubMed

    Liu, Xueqin; Li, Ning; Xie, Wei; Wu, Jidong; Zhang, Peng; Ji, Zhonghui

    2012-09-01

    This study presents a methodology for return period analysis and risk assessment of severe dust storm disaster. Meteorological observation data, soil moisture data, and remote sensing data from 30 meteorological stations in Inner Mongolia (western China) from 1985 to 2006 were used for the study. A composite index of severe dust storm disaster (Index I (SDS)) based on the influence mechanisms of the main contributing factors was developed by using the analytic hierarchy process and the weighted comprehensive method, and the hazard risk curves (i.e., the transcendental probability curves of I (SDS)) for the 30 stations were established using the parameter estimation method. We then analyzed the risk of the occurrence of severe dust storm under different scenarios of 5-, 10-, 20-, and 50-year return periods. The results show that the risk decreased from west to east across Inner Mongolia, and there are four severe dust storm occurrence peak value centers, including Guaizihu, Jilantai, Hailisu, and Zhurihe-Erenhot. The severity of dust storms in seven places will be intolerable in the 50-year return period scenario and in three places in the 20-year return period scenario. These results indicate that these locations should concentrate forces on disaster prevention, monitoring, and early warning. The I (SDS) was developed as an easily understandable tool useful for the assessment and comparison of the relative risk of severe dust storm disasters in different areas. The risk assessment was specifically intended to support local and national government agencies in their management of severe dust storm disasters in their efforts to (1) make resource allocation decisions, (2) make high-level planning decisions, and (3) raise public awareness of severe dust storm risk. PMID:21956339

  19. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 6 2014-04-01 2014-04-01 false Returns for periods of less than 12 months. 1.443-1 Section 1.443-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Accounting Periods § 1.443-1 Returns for periods of less than 12 months. (a) Returns for...

  20. 50 years of fiber diffraction.

    PubMed

    Holmes, Kenneth C

    2010-05-01

    In 1955 Ken Holmes started working on tobacco mosaic virus (TMV) as a research student with Rosalind Franklin at Birkbeck College, London. Afterward he spent 18months as a post doc with Don Caspar and Carolyn Cohen at the Children's Hospital, Boston where he continued the work on TMV and also showed that the core of the thick filament of byssus retractor muscle from mussels is made of two-stranded alpha-helical coiled-coils. Returning to England he joined Aaron Klug's group at the newly founded Laboratory of Molecular Biology in Cambridge. Besides continuing the TMV studies, which were aimed at calculating the three-dimensional density map of the virus, he collaborated with Pringle's group in Oxford to show that two conformation of the myosin cross-bridge could be identified in insect flight muscle. In 1968 he opened the biophysics department at the Max Planck Institute for Medical Research in Heidelberg, Germany. With Gerd Rosenbaum he initiated the use of synchrotron radiation as a source for X-ray diffraction. In his lab the TMV structure was pushed to 4A resolution and showed how the RNA binds to the protein. With his co-workers he solved the structure of g-actin as a crystalline complex and then solved the structure of the f-actin filament by orientating the g-actin structure so as to give the f-actin fiber diffraction pattern. He was also able to solve the structure of the complex of actin with tropomyosin from fiber diffraction. PMID:20079849

  1. Looking back 50 years in hospital administration.

    PubMed

    Graham, Ross; Sibbald, Shannon L

    2012-01-01

    Healthcare policy and hospital administration are dynamic and growing fields, oriented toward shaping the future. In an effort to understand where these fields have come from, as well as some of the re-occuring challenges faced, we conducted a retrospective analysis. Our research identified progress and major accomplishments, as well as issues that continue to challenge the field in five key areas: (1) the evolution of nursing, (2) funding and legislation, (3) hospital design, construction and technology, (4) patient care and infection control and (5) leadership. To explore these areas, a thematic content review was conducted on the 12 inaugural issues of Hospital Administration in Canada, a hospital administration periodical from 1962. All written content was reviewed, coded and categorized into major themes that represented the major hospital administration topics of 50 years ago. In this article, five prominent themes are explored and further illustrated using key stories and milestones from 1962. PMID:23107901

  2. On the effect of the sampling frequency of sea level measurements on return period estimate of extremes—Southern European examples

    NASA Astrophysics Data System (ADS)

    Tsimplis, M. N.; Marcos, M.; Pérez, B.; Challenor, P.; Garcia-Fernandez, M. J.; Raicich, F.

    2009-10-01

    Estimates of extreme sea levels and return periods have been based mainly on hourly sampling rates. Technological development has enabled the sampling rates to increase and sampling rates of 5-10 min are becoming increasingly common. In this paper we explore the relationship between extreme sea levels and estimated return periods based on hourly and shorter sampling periods in three tide-gauges one at the Atlantic coasts of Spain (Coruña), one in the western Mediterranean (Malaga) and one in the N. Adriatic (Trieste). Significant differences of several centimetres are found in the hourly and 5 min extremes. These reflect in significant underestimation of the 50-year return levels which in Trieste reach 38 cm. A theoretical relationship between the high and the low sampling rate of extremes is also tested. Thus updated 50-year return levels for the Mediterranean and the coasts of the Iberian peninsula are produced assuming that the differences identified in the various stations generalise to other tide-gauge (hourly) records for which hourly values have been analysed earlier.

  3. Return periods of losses associated with European windstorm series in a changing climate

    NASA Astrophysics Data System (ADS)

    Karremann, Melanie K.; Pinto, Joaquim G.; Reyers, Mark; Klawa, Matthias

    2015-04-01

    During the last decades, several windstorm series hit Europe leading to large aggregated losses. Such storm series are examples of serial clustering of extreme cyclones, presenting a considerable risk for the insurance industry. Clustering of events and return periods of storm series affecting Europe are quantified based on potential losses using empirical models. Moreover, possible future changes of clustering and return periods of European storm series with high potential losses are quantified. Historical storm series are identified using 40 winters of NCEP reanalysis data (1973/1974 - 2012/2013). Time series of top events (1, 2 or 5 year return levels) are used to assess return periods of storm series both empirically and theoretically. Return periods of historical storm series are estimated based on the Poisson and the negative binomial distributions. Additionally, 800 winters of ECHAM5/MPI-OM1 general circulation model simulations for present (SRES scenario 20C: years 1960- 2000) and future (SRES scenario A1B: years 2060- 2100) climate conditions are investigated. Clustering is identified for most countries in Europe, and estimated return periods are similar for reanalysis and present day simulations. Future changes of return periods are estimated for fixed return levels and fixed loss index thresholds. For the former, shorter return periods are found for Western Europe, but changes are small and spatially heterogeneous. For the latter, which combines the effects of clustering and event ranking shifts, shorter return periods are found everywhere except for Mediterranean countries. These changes are generally not statistically significant between recent and future climate. However, the return periods for the fixed loss index approach are mostly beyond the range of preindustrial natural climate variability. This is not true for fixed return levels. The quantification of losses associated with storm series permits a more adequate windstorm risk assessment in a

  4. Stochastic long term modelling of a drainage system with estimation of return period uncertainty.

    PubMed

    Thorndahl, S

    2009-01-01

    Long term prediction of maximum water levels and combined sewer overflow (CSO) in drainage systems are associated with large uncertainties. Especially on rainfall inputs, parameters, and assessment of return periods. This paper proposes a Monte Carlo based methodology for stochastic prediction of both maximum water levels as well as CSO volumes based on operations of the urban drainage model MOUSE in a single catchment case study. Results show quite a wide confidence interval of the model predictions especially on the large return periods. Traditionally, return periods of drainage system predictions are based on ranking, but this paper proposes a new methodology for the assessment of return periods. Based on statistics of characteristic rainfall parameters and correlation with drainage system predictions, it is possible to predict return periods more reliably, and with smaller confidence bands compared to the traditional methodology. PMID:19542638

  5. 50 years of Global Seismic Observations

    NASA Astrophysics Data System (ADS)

    Anderson, K. R.; Butler, R.; Berger, J.; Davis, P.; Derr, J.; Gee, L.; Hutt, C. R.; Leith, W. S.; Park, J. J.

    2007-12-01

    Seismological recordings have been made on Earth for hundreds of years in some form or another, however, global monitoring of earthquakes only began in the 1890's when John Milne created 40 seismic observatories to measure the waves from these events. Shortly after the International Geophysical Year (IGY), a concerted effort was made to establish and maintain a more modern standardized seismic network on the global scale. In the early 1960's, the World-Wide Standardized Seismograph Network (WWSSN) was established through funding from the Advanced Research Projects Agency (ARPA) and was installed and maintained by the USGS's Albuquerque Seismological Laboratory (then a part of the US Coast and Geodetic Survey). This network of identical seismic instruments consisted of 120 stations in 60 countries. Although the network was motivated by nuclear test monitoring, the WWSSN facilitated numerous advances in observational seismology. From the IGY to the present, the network has been upgraded (High-Gain Long-Period Seismograph Network, Seismic Research Observatories, Digital WWSSN, Global Telemetered Seismograph Network, etc.) and expanded (International Deployment of Accelerometers, US National Seismic Network, China Digital Seismograph Network, Joint Seismic Project, etc.), bringing the modern day Global Seismographic Network (GSN) to a current state of approximately 150 stations. The GSN consists of state-of-the-art very broadband seismic transducers, continuous power and communications, and ancillary sensors including geodetic, geomagnetic, microbarographic, meteorological and other related instrumentation. Beyond the GSN, the system of global network observatories includes contributions from other international partners (e.g., GEOSCOPE, GEOFON, MEDNET, F-Net, CTBTO), forming an even larger backbone of permanent seismological observatories as a part of the International Federation of Digital Seismograph Networks. 50 years of seismic network operations have provided

  6. 50 years of snow stratigraphy observations

    NASA Astrophysics Data System (ADS)

    Johansson, C.; Pohjola, V.; Jonasson, C.; Challagan, T. V.

    2012-04-01

    With start in autumn 1961 the Abisko Scientific Research Station (ASRS) located in the Swedish sub Arctic has performed snow stratigraphy observations, resulting in a unique 50 year long time series of data. The data set contains grain size, snow layer hardness, grain compactness and snow layer dryness, observed every second week during the winter season. In general snow and snow cover are important factors for the global radiation budget, and the earth's climate. On a more local scale the layered snowpack creates a relatively mild microclimate for Arctic plants and animals, and it also determines the water content of the snowpack (snow water equivalent) important for e.g. hydrological applications. Analysis of the snow stratigraphy data, divided into three consecutive time periods, show that there has been a change in the last time period. The variable most affected is the snow layer hardness, which shows an increase in hardness of the snowpack. The number of observations with a very hard snow layer/ice at ground level increased three-fold between the first two time periods and the last time period. The thickness of the bottom layer in the snowpack is also highly affected. There has been a 60% increase in layers thinner than 10 cm in the last time period, resulting in a mean reduction in the thickness of the bottom layer from 14 cm to 11 cm. Hence the living conditions for plants and animals at the ground surface have been highly changed. The changes in the snowpack are correlated to an increased mean winter air temperature. Thus, continued increasing, or temperatures within the same ranges as in the last time period, is likely to create harder snow condition in the future. These changes are likely to affect animals that live under the snow such as lemmings and voles or animals that graze sub-Arctic vegetation in winter (e.g. reindeer that would potentially require increased supplementary feeding that incurs financial costs to Sami reindeer herders). Any decrease

  7. Estimating return periods of extreme values from relatively short time series of winds

    NASA Astrophysics Data System (ADS)

    Jonasson, Kristjan; Agustsson, Halfdan; Rognvaldsson, Olafur; Arfeuille, Gilles

    2013-04-01

    An important factor for determining the prospect of individual wind farm sites is the frequency of extreme winds at hub height. Here, extreme winds are defined as the value of the highest 10 minutes averaged wind speed with a 50 year return period, i.e. annual exceeding probability of 2% (Rodrigo, 2010). A frequently applied method to estimate winds in the lowest few hundred meters above ground is to extrapolate observed 10-meter winds logarithmically to higher altitudes. Recent study by Drechsel et al. (2012) showed however that this methodology is not as accurate as interpolating simulated results from the global ECMWF numerical weather prediction (NWP) model to the desired height. Observations of persistent low level jets near Colima in SW-Mexico also show that the logarithmic approach can give highly inaccurate results for some regions (Arfeuille et al., 2012). To address these shortcomings of limited, and/or poorly representative, observations and extrapolations of winds one can use NWP models to dynamically scale down relatively coarse resolution atmospheric analysis. In the case of limited computing resources one has typically to make a compromise between spatial resolution and the duration of the simulated period, both of which can limit the quality of the wind farm siting. A common method to estimate maximum winds is to fit an extreme value distribution (e.g. Gumbel, gev or Pareto) to the maximum values of each year of available data, or the tail of these values. If data are only available for a short period, e.g. 10 or 15 years, then this will give a rather inaccurate estimate. It is possible to deal with this problem by utilizing monthly or weekly maxima, but this introduces new problems: seasonal variation, autocorrelation of neighboring values, and increased discrepancy between data and fitted distribution. We introduce a new method to estimate return periods of extreme values of winds at hub height from relatively short time series of winds, simulated

  8. 50 years of membership in AGU recognized

    NASA Astrophysics Data System (ADS)

    Recently, 14 AGU members who joined the Union in 1937 received their recognition pins for 50 years of membership in the Union. They join the distinguished ranks of the 50- year AGU members, who are listed below by the year that they joined:1937 A.B. Bryan, Leonard B. Corwin, Tate Dalrymple, Richard H. Fleming, Harry L. Frauenthal, Konrad B. Krauskopf, J. Stuart Meyers, Brian O'Brien, Joseph F. Poland, Edward J. Rutter, Noel H. Stearn, John P. Tully, Victor Vacquier, G.H. Westby, and Harvey O. Westby.

  9. Ned Greenberg: 50 Years and Counting | Poster

    Cancer.gov

    By Ashley DeVine, Staff Writer Can you imagine working for the same company for 50 years? Nathaniel “Ned” Greenberg has accomplished just that, having recently received his 50-year service award from NIH, and he has no immediate plans for retirement. “I don’t look upon my job as a chore, it’s more of an avocation than a vocation,” said Greenberg, a chemist in the Biological Testing Branch (BTB), under Branch Chief Melinda Hollingshead, DVM, Ph.D. “I am lucky that I found something that I enjoy doing.”

  10. Return period adjustment for runoff coefficients based on analysis in undeveloped Texas watersheds

    USGS Publications Warehouse

    Dhakal, Nirajan; Fang, Xing; Asquith, William H.; Cleveland, Theodore G.; Thompson, David B.

    2013-01-01

    The rational method for peak discharge (Qp) estimation was introduced in the 1880s. The runoff coefficient (C) is a key parameter for the rational method that has an implicit meaning of rate proportionality, and the C has been declared a function of the annual return period by various researchers. Rate-based runoff coefficients as a function of the return period, C(T), were determined for 36 undeveloped watersheds in Texas using peak discharge frequency from previously published regional regression equations and rainfall intensity frequency for return periods T of 2, 5, 10, 25, 50, and 100 years. The C(T) values and return period adjustments C(T)/C(T=10  year) determined in this study are most applicable to undeveloped watersheds. The return period adjustments determined for the Texas watersheds in this study and those extracted from prior studies of non-Texas data exceed values from well-known literature such as design manuals and textbooks. Most importantly, the return period adjustments exceed values currently recognized in Texas Department of Transportation design guidance when T>10  years.

  11. The Business Schools: 50 Years on

    ERIC Educational Resources Information Center

    Clarke, Thomas

    2008-01-01

    Purpose: This paper aims to offer a critique of the development of university business schools over the last 50 years and provide a perspective on the occasion of the 50th anniversary of the publication of the journal Education + Training. Design/methodology/approach: The approach is critical and reflexive, reviewing the historical growth of…

  12. Estimation of the return period for Gumbel processes with applications to air quality measures. Technical report No. 36

    SciTech Connect

    Galfond, G

    1980-03-01

    The return period for a pollutant concentration to exceed a given level is often of interest. For example, the return period for exceeding government standards is a useful measure of long term air quality. Or, for medical reasons, one might be interested in the return period for exceeding some significant harm level. The report examines several estimates of the return period based on extreme value theory and illustrates applications to air quality data.

  13. Development of a wind gust model to estimate gust speeds and their return periods

    NASA Astrophysics Data System (ADS)

    Seregina, Larisa; Haas, Rabea; Born, Kai; Pinto, Joaquim G.

    2014-05-01

    Spatially dense observations of gust speeds are necessary for various applications, but their availability is limited in space and time. This work presents an approach to help to overcome this problem. The main objective is the generation of synthetic wind gust velocities. With this aim, theoretical wind and gust distributions are estimated from ten years of hourly observations collected at 123 synoptic weather stations provided by the German Weather Service. In a first step, an exposure correction is applied on measurements of the mean wind velocity to reduce the influence of local urban and topographic effects. In a second step, a transfer function is built between distribution parameters of wind and gust velocities. The aim of this step is to estimate the parameters of gusts at stations where only wind speed data is available. These parameters can be used in a third step to generate synthetic gusts, which can improve the accuracy of return periods at test sites with a lack of observations. The second objective is to determine return periods much longer than the nominal length of the original time series by considering extreme value statistics. Estimates for both local maximum return periods and average return periods for single historical events are provided. The comparison of maximum and average return periods shows that even storms with short average return periods may lead to local wind gusts with return periods of several decades. Despite uncertainties caused by the short length of the observational records, the method leads to consistent results, enabling a wide range of possible applications.

  14. Paediatric infectious diseases: the last 50 years.

    PubMed

    Starr, Mike

    2015-01-01

    Many advances and challenges have occurred in the field of paediatric infectious diseases during the past 50 years. It is impossible to cover all of these in a short review, but a few highlights and lowlights will be covered. These include virtual disappearance of some infectious diseases, emergence of new ones, infections in the immunocompromised, antimicrobial resistance, development of new and improved antimicrobials, improved diagnostic tests and the Human Microbiome Project. PMID:25557805

  15. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 6 2013-04-01 2013-04-01 false Returns for periods of less than 12 months. 1.443-1 Section 1.443-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... period ($18,836×1/12) 1,570 Example 3. The Y Corporation makes a re- turn for the six-month period...

  16. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 6 2012-04-01 2012-04-01 false Returns for periods of less than 12 months. 1.443-1 Section 1.443-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... period ($18,836×1/12) 1,570 Example 3. The Y Corporation makes a re- turn for the six-month period...

  17. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false Returns for periods of less than 12 months. 1.443-1 Section 1.443-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... period ($18,836×1/12) 1,570 Example 3. The Y Corporation makes a re- turn for the six-month period...

  18. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 6 2011-04-01 2011-04-01 false Returns for periods of less than 12 months. 1.443-1 Section 1.443-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... period ($18,836×1/12) 1,570 Example 3. The Y Corporation makes a re- turn for the six-month period...

  19. Estimation of return periods of multiple losses per winter associated with historical windstorm series over Germany

    NASA Astrophysics Data System (ADS)

    Karremann, Melanie; Pinto, Joaquim G.; von Bomhard, Philipp; Klawa, Matthias

    2014-05-01

    During the last decades, several windstorm series hit Western Europe leading to large cumulative economic losses. Such storm series are an example of serial clustering of extreme cyclones and present a considerable risk for the insurance industry. Here, clustering of events and return periods of storm series for Germany are quantified based on potential losses using empirical models. Two reanalysis datasets and observations from 123 German Weather Service stations are considered for the winters 1981/1982 to 2010/2011. Based on these datasets, histograms of events exceeding selected return levels (1-, 2- and 5-year) are derived. Return periods of historical storm series are estimated based on the Poisson and the negative Binomial distribution. About 4680 years of global circulation model simulations forced with current climate conditions are analysed to provide a better assessment of historical return periods. Estimations differ between the considered distributions. Except for frequent and weak events, the return period estimates obtained with the Poisson distribution clearly deviate from empirical data. This clearly documents overdispersion in the loss data, thus indicating the clustering of potential loss events. Better assessments are achieved for the negative Binomial distribution, e.g. 34 to 53 years for the storm series like 1989/1990. The overdispersion (clustering) of potential loss events clearly states the importance of an adequate risk assessment of multiple events per winter for economical applications.

  20. The Kerr Metric: 50 Years Later

    NASA Astrophysics Data System (ADS)

    Teukolsky, Saul

    2015-04-01

    I will describe the events leading up to the discovery of the Kerr metric in 1963 and the enormous impact the discovery has had in the subsequent 50 years. The talk will emphasize the ``miraculous'' nature of the solution, both as a simple analytic formula describing the most general rotating black hole, and as having unexpected mathematical properties that make many calculations tractable. Supported in part by NSF Grants PHY-1306125 and No. AST-1333129 at Cornell University, and by a grant from the Sherman Fairchild Foundation.

  1. Severe wind gust thresholds for Meteoalarm derived from uniform return periods in ECA&D

    NASA Astrophysics Data System (ADS)

    Stepek, A.; Wijnant, I. L.; van der Schrier, G.; van den Besselaar, E. J. M.; Klein Tank, A. M. G.

    2012-06-01

    In this study we present an alternative wind gust warning guideline for Meteoalarm, the severe weather warning website for Europe. There are unrealistically large differences in levels and issuing frequencies of all warning levels currently in use between neighbouring Meteoalarm countries. This study provides a guide for the Meteoalarm community to review their wind gust warning thresholds. A more uniform warning system is achieved by using one pan-European return period per warning level. The associated return values will be different throughout Europe because they depend on local climate conditions, but they will not change abruptly at country borders as is currently the case for the thresholds. As return values are a measure of the possible danger of an event and its impact on society, they form an ideal basis for a warning system. Validated wind gust measurements from the European Climate Assessment and Dataset (ECA&D, http://www.ecad.eu) were used to calculate return values of the annual maximum wind gust. The current thresholds are compared with return values for 3 different return periods: 10 times a year return periods for yellow warnings, 2 yr periods for orange and 5 yr periods for red warnings. So far 10 countries provide wind gust data to ECA&D. Due to the ECA&D completeness requirements and the fact that some countries provided too few stations to be representative for that country, medians of the return values of annual maximum wind gust could be calculated for 6 of the 10 countries. Alternative guideline thresholds are presented for Norway, Ireland, The Netherlands, Germany, the Czech Republic and Spain and the need to distinguish between coastal, inland and mountainous regions is demonstrated. The new thresholds based on uniform return periods differ significantly from the current ones, particularly for coastal and mountainous areas. We are aware of other, sometimes binding factors (e.g. laws) that

  2. Child protection: a 50-year perspective.

    PubMed

    Skellern, Catherine Yvette

    2015-01-01

    It has been 50 years since Kempe et al. published 'The Battered Child Syndrome', describing harm from inflicted injury mechanisms derived from parents and care givers. Since then, there has emerged a rapidly expanding literature on paediatric forensic medicine and child protection, which has offered new insights into injury mechanisms, informed us of the sequelae of abuse and neglect, aided diagnosis and guided clinical practice in the treatment and management of children who become involved in the child protection system. Through the scrutiny of government inquiries and at times uncomfortable media exposure, there have been improvements in child protection and forensic practices resulting in recognition of need for specialised forensic training, improved funding, development of resources and development of professional standards that support accountable, objective, safe and robust practice. From the perspective of an Australian child protection paediatrician, this paper chronicles some of the most significant and at times controversial research in the last 50 years in child protection that have played a key role in shaping our current understanding of child abuse and neglect. PMID:25534472

  3. 50 years of radiation research: medicine.

    PubMed

    Phillips, Theodore L

    2002-10-01

    The advances brought about by research in radiation medicine over the past 50 years are presented. The era began with the atomic explosions in Hiroshima and Nagasaki and the establishment of the Atomic Bomb Casualty Commission to understand what damage was caused by exposure of a large population to radiation. A better understanding of the effects of whole-body exposure led to the development of whole-body radiation treatment techniques and to bone marrow transplantation in the treatment of leukemias. The field of diagnostic imaging was revolutionized by a series of inventions that included angiography, mammography, computed tomography, magnetic resonance imaging, magnetic resonance spectroscopy, and ultrasound imaging. The field of nuclear medicine came of age through new man-made radionuclides and the invention of scanning and imaging techniques including positron emission tomography. Radiotherapy, a minor sideline of radiology, developed into radiation oncology, an extremely important component of modern cancer therapy. The advances in clinical radiotherapy were made possible by discoveries and inventions in physics and engineering and by insights and discoveries in radiobiology. The result of the last 50 years of progress is a very powerful set of clinical tools. PMID:12236808

  4. The return period analysis of natural disasters with statistical modeling of bivariate joint probability distribution.

    PubMed

    Li, Ning; Liu, Xueqin; Xie, Wei; Wu, Jidong; Zhang, Peng

    2013-01-01

    New features of natural disasters have been observed over the last several years. The factors that influence the disasters' formation mechanisms, regularity of occurrence and main characteristics have been revealed to be more complicated and diverse in nature than previously thought. As the uncertainty involved increases, the variables need to be examined further. This article discusses the importance and the shortage of multivariate analysis of natural disasters and presents a method to estimate the joint probability of the return periods and perform a risk analysis. Severe dust storms from 1990 to 2008 in Inner Mongolia were used as a case study to test this new methodology, as they are normal and recurring climatic phenomena on Earth. Based on the 79 investigated events and according to the dust storm definition with bivariate, the joint probability distribution of severe dust storms was established using the observed data of maximum wind speed and duration. The joint return periods of severe dust storms were calculated, and the relevant risk was analyzed according to the joint probability. The copula function is able to simulate severe dust storm disasters accurately. The joint return periods generated are closer to those observed in reality than the univariate return periods and thus have more value in severe dust storm disaster mitigation, strategy making, program design, and improvement of risk management. This research may prove useful in risk-based decision making. The exploration of multivariate analysis methods can also lay the foundation for further applications in natural disaster risk analysis. PMID:22616629

  5. 7 CFR 273.32 - Households who return to TANF during the transitional period.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Households who return to TANF during the transitional period. 273.32 Section 273.32 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION...

  6. 7 CFR 273.32 - Households who return to TANF during the transitional period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Households who return to TANF during the transitional period. 273.32 Section 273.32 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION...

  7. 7 CFR 273.32 - Households who return to TANF during the transitional period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Households who return to TANF during the transitional period. 273.32 Section 273.32 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION...

  8. 7 CFR 273.32 - Households who return to TANF during the transitional period.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Households who return to TANF during the transitional period. 273.32 Section 273.32 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION...

  9. Ceremony celebrates 50 years of rocket launches

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Ceremony celebrates 50 years of rocket launches PL00C-10364.12 At the 50th anniversary ceremony celebrating the first rocket launch from pad 3 on what is now Cape Canaveral Air Force Station, Norris Gray waves to the audience. Gray was part of the team who successfully launched the first rocket, known as Bumper 8. The ceremony was hosted by the Air Force Space & Missile Museum Foundation, Inc. , and included launch of a Bumper 8 model rocket, presentation of a Bumper Award to Florida Sen. George Kirkpatrick by the National Space Club; plus remarks by Sen. Kirkpatrick, KSC's Center Director Roy Bridges, and the Commander of the 45th Space Wing, Brig. Gen. Donald Pettit. Also attending the ceremony were other members of the original Bumper 8 team. A reception followed at Hangar C. Since 1950 there have been a total of 3,245 launches from Cape Canaveral.

  10. A New Minority 50 Years after "Brown"

    ERIC Educational Resources Information Center

    Hardy, Lawrence

    2004-01-01

    Legal segregation might be dead, but many metropolitan schools remain overwhelmingly black and poor--a result of years of white flight from central cities and recent court decisions accelerating a return to neighborhood schools. At the same time, the bourgeoning Hispanic population is finding itself in increasingly segregated schools across the…

  11. [Medical research ethics 50 years after Nuremberg].

    PubMed

    Ruyter, K W

    1997-12-10

    50 years ago, in Nuremberg, 23 German doctors were accused of crimes against humanity. The anniversary is a solemn reminder of the dark origins of medical research ethics. Many researchers today believe that the medical experiments carried out under Hitler "vaccinated" postwar researchers against abuse. A review of the practices of postwar research shows that the "vaccination" had limited effect and that there is no reason to believe that the events which took place under Hitler were unique and will never happen again. After the war various measures were introduced to protect research subjects: informed consent, self regulation and independent research ethics committees. The measures have undoubtedly limited the abuse of subjects substantially. Nevertheless, in the Armed Forces, where abuse has been most rampant after the war, informed consent is not always practised and independent review is seldom carried out. With the support of grant institutions, journals and industry the protection of research subjects can be improved. It is recommended that medical faculties arrange an annual commemoration of the victims of medical research in order to raise consciousness and awareness among teachers and students. PMID:9456583

  12. Proportional mortality of 50 years and above

    PubMed Central

    Swaroop, S.; Uemura, K.

    1957-01-01

    In 1954 the United Nations Committee of Experts on International Definition and Measurement of Standards and Levels of Living suggested that for the measurement of levels of living quantifiable or potentially quantifiable components should be considered separately. An attempt is made in the present paper to evolve a single, comprehensive numerical indicator to quantify the component “health, including demographic conditions”. The use of an objective statistical technique as a guide in the selection of such an indicator is suggested. From the application of this technique, it is concluded that the percentage of deaths at the ages 50 years and over to total deaths (proportional mortality) affords a fairly suitable yardstick by which broad inter-country comparisons may be made. This indicator has the advantages of simplicity of calculation, comprehensiveness, availability of data, possibility of international comparability despite the varying quality of basic statistical information, sensitivity for the purpose of inter-country comparisons, and validity for studying levels and trends. PMID:13500159

  13. Launchers - The first 50-year cycle

    NASA Astrophysics Data System (ADS)

    Pardoe, G. K. C.

    1986-11-01

    An assessment is made of the development history of spacecraft launch vehicles to the present date, with attention to mission economics and the criteria of profitability. Three technological generations are postulated: that dominated by expendable launch vehicles, lasting from 1957 to the introduction of the Space Shuttle; the Space Shuttle period of semireusable launch vehicles; and the soon-to-be-inaugurated era of fully reusable launchers which are expected to begin operations around the year 2000.

  14. Atoms for Peace after 50 Years

    DOE R&D Accomplishments Database

    Joeck, N.; Lehman, R. F.; Vergino, E. S.; Schock, R. N.

    2004-03-20

    President Eisenhower's hopes for nuclear technology still resonate, but the challenges to fulfilling them are much different today. On December 8, 1953, President Eisenhower, returning from his meeting with the leaders of Britain and France at the Bermuda Summit, flew directly to New York to address the United Nations General Assembly. His presentation, known afterwards as the "Atoms for Peace" speech, was bold, broad, and visionary. Eisenhower highlighted dangers associated with the further spread of nuclear weapons and the end of the thermonuclear monopoly, but the president also pointed to opportunities. Earlier that year, Stalin had died and the Korean War armistice was signed. Talks on reunification of Austria were about to begin. The speech sought East-West engagement and outlined a framework for reducing nuclear threats to security while enhancing the civilian benefits of nuclear technology. One specific proposal offered to place surplus military fissile material under the control of an "international atomic energy agency" to be used for peaceful purposes, especially economic development. Eisenhower clearly recognized the complex interrelationships between different nuclear technologies and the risks and the benefits that accrue from each. The widespread use of civilian nuclear technology and absence of any use of a nuclear weapon during the next half-century reflects success in his approach. Today, the world faces choices about nuclear technology that have their parallels in the Eisenhower calculus and its legacy. Although his specific fissile material proposal was never implemented, his broader themes gave impetus to agreements such as the nuclear Non-Proliferation Treaty (NPT) and institutions such as the International Atomic Energy Agency (IAEA). The resulting governance process has promoted some and restricted other nuclear technology. Perhaps even more influential was Eisenhower's overarching recommendation that we try to reduce the risks and seek the

  15. Challenges estimating the return period of extreme floods for reinsurance applications

    NASA Astrophysics Data System (ADS)

    Raven, Emma; Busby, Kathryn; Liu, Ye

    2013-04-01

    Mapping and modelling extreme natural events is fundamental within the insurance and reinsurance industry for assessing risk. For example, insurers might use a 1 in 100-year flood hazard map to set the annual premium of a property, whilst a reinsurer might assess the national scale loss associated with the 1 in 200-year return period for capital and regulatory requirements. Using examples from a range of international flood projects, we focus on exploring how to define what the n-year flood looks like for predictive uses in re/insurance applications, whilst considering challenges posed by short historical flow records and the spatial and temporal complexities of flood. First, we shall explore the use of extreme value theory (EVT) statistics for extrapolating data beyond the range of observations in a marginal analysis. In particular, we discuss how to estimate the return period of historical flood events and explore the impact that a range of statistical decisions have on these estimates. Decisions include: (1) selecting which distribution type to apply (e.g. generalised Pareto distribution (GPD) vs. generalised extreme value distribution (GEV)); (2) if former, the choice of the threshold above which the GPD is fitted to the data; and (3) the necessity to perform a cluster analysis to group flow peaks to temporally represent individual flood events. Second, we summarise a specialised multivariate extreme value model, which combines the marginal analysis above with dependence modelling to generate industry standard event sets containing thousands of simulated, equi-probable floods across a region/country. These events represent the typical range of anticipated flooding across a region and can be used to estimate the largest or most widespread events that are expected to occur. Finally, we summarise how a reinsurance catastrophe model combines the event set with detailed flood hazard maps to estimate the financial cost of floods; both the full event set and also

  16. [Experimental study of the root supply system with periodic water return designed for space greenhouses].

    PubMed

    Berkovich, Iu A; Smolianina, S O; Krivobok, N M

    2000-01-01

    To improve reliability of plant's moistening and aeration control in microgravity, an original root supply system with a periodic return water flow has been designed and tested in laboratory. For 30 days crops of Pekinese cabbage (Brassica pekinesis (Lour Rupr), Khibini sort) were raised in the test bench which allowed adjustment of water potential in the root zone within a preset range. A three-step water potential control algorithm included water injection with a pump-dispenser, a pause, and water sucking back to a desired value of water potential. The following parameters of the control cycle were selected in a series of two experiments: time of water injection (2.5 hr) and return (1.5 hr), and a pause of 8 and 20 hr, respectively. Magnitude of water potential about the root module axis was controlled in the range from -1.3 kPa to -3.0 kPa in both experiments and maintained at -1.3 kPa in the control. The root modules consisted of porous metaloceramic tubes wrapped in fibrous ion exchanging cloth and a light-proof film with planting slots on top. In the first experiment, plant characteristics were comparable to the control. The developed procedure and technology can be used to provide favourable moisture-air conditions in the root zone. By and large, the system of root nutrition with a periodic water return has demonstrated high capacity during the ground-based cultivation of plants. To use this system in space greenhouse, it is necessary to specify operational parameters for the microgravity environment. PMID:10826063

  17. Levee reliability analyses for various flood return periods - a case study in southern Taiwan

    NASA Astrophysics Data System (ADS)

    Huang, W.-C.; Yu, H.-W.; Weng, M.-C.

    2015-04-01

    In recent years, heavy rainfall conditions have caused disasters around the world. To prevent losses by floods, levees have often been constructed in inundation-prone areas. This study performed reliability analyses for the Chiuliao First Levee in southern Taiwan. The failure-related parameters were the water level, the scouring depth, and the in situ friction angle. Three major failure mechanisms were considered: the slope sliding failure of the levee and the sliding and overturning failures of the retaining wall. When the variability of the in situ friction angle and the scouring depth are considered for various flood return periods, the variations of the factor of safety for the different failure mechanisms show that the retaining wall sliding and overturning failures are more sensitive to the change of the friction angle. When the flood return period is greater than 2 years, the levee could fail with slope sliding for all values of the water level difference. The results of levee stability analysis considering the variability of different parameters could aid engineers in designing the levee cross sections, especially with potential failure mechanisms in mind.

  18. Levee reliability analyses for various flood return periods - a case study in Southern Taiwan

    NASA Astrophysics Data System (ADS)

    Huang, W.-C.; Yu, H.-W.; Weng, M.-C.

    2015-01-01

    In recent years, heavy rainfall conditions have caused damages around the world. To prevent damages by floods, levees have often been constructed in prone-to-inundation areas. This study performed reliability analyses for the Chiuliao 1st Levee located in southern Taiwan. The failure-related parameters were the water level, the scouring depth, and the in-situ friction angle. Three major failure mechanisms were considered, including the slope sliding failure of the levee, and the sliding and overturning failures of the retaining wall. When the variabilities of the in-situ friction angle and the scouring depth are considered for various flood return periods, the variations of the factor of safety (FS) for the different failure mechanisms show that the retaining wall sliding and overturning failures are more sensitive to the variability of the friction angle. When the flood return period is greater than 2 years, the levee can undergo slope sliding failure for all values of the water level difference. The results for levee stability analysis considering the variability of different parameters could assist engineers in designing the levee cross sections, especially with potential failure mechanisms in mind.

  19. The First 50 Years of Konkoly Observatory

    NASA Astrophysics Data System (ADS)

    Balazs, Lajos G.; Vargha, Magda; Zsoldos, Endre

    The second half of the 19th century experienced a revolution in astronomy. It coincided with a new start of professional astronomy in Hungary through the work of Miklós Konkoly Thege (1842-1916) who is considered as a pioneer of current astrophysical activity in our country. He played an outstanding role in organizing scientific life and institutions, too. He started observations in his newly founded Observatory at Ógyalla in 1871. Sunspots were regularly observed in the observatory from 1872. In 1874 Konkoly began regular spectroscopic observations of comets and emphasized the importance of parallel laboratory works. An important field of Konkoly's astronomical activity was the observation of surface patterns of planets, particularly that of Jupiter and Mars. Spectroscopic observations of stars were also a significant part of the activity of Ógyalla Observatory. In the last period of the Konkoly era (starting in 1899) stellar photometry became the main field of research. At the end of WW I the institute was moved to Budapest Ógyalla and started a new life based on a completely new infrastructure: “... all era are followed by a new one, with its new tasks, in which the scope of activity changes correspondingly, in which enthusiasm is mostly manifested. It was different in the forties when our nation found itself following the word of the founder of our Academy, it was different in the fifties and sixties when we have to defend our nation against foreign aggression, and it became different since the sixties when, our existence being guarantied, we also have to make an effort, beside strengthening it, to get as distinguished a position among the civilized nations as possible.”

  20. Plague reappearance in Algeria after 50 years, 2003.

    PubMed

    Bertherat, Eric; Bekhoucha, Souad; Chougrani, Saada; Razik, Fathia; Duchemin, Jean B; Houti, Leila; Deharib, Larbi; Fayolle, Corinne; Makrerougrass, Banaouda; Dali-Yahia, Radia; Bellal, Ramdan; Belhabri, Leila; Chaieb, Amina; Tikhomirov, Evgueni; Carniel, Elisabeth

    2007-10-01

    An outbreak of plague occurred in the region of Oran, Algeria, from June to July 2003. Algeria had not reported this disease for >50 years. Eighteen bubonic cases were identified, and Yersinia pestis was isolated from 6 patients. Except for the index case-patient, all patients recovered. Targeted chemoprophylaxis, sanitation, and vector control played a crucial role in controlling the outbreak. Epidemiologic and biomolecular findings strongly suggested the existence of a local animal reservoir during this period, but its origin (resurgence or re-importation) could not be determined. This sudden and unexpected reemergence of plague, close to an important commercial seaport, is a textbook illustration of a public health event of international importance. It also demonstrates that the danger of plague reoccurrence is not limited to the currently indexed natural foci. PMID:18257987

  1. Plague Reappearance in Algeria after 50 Years, 2003

    PubMed Central

    Bekhoucha, Souad; Chougrani, Saada; Razik, Fathia; Duchemin, Jean B.; Houti, Leila; Deharib, Larbi; Fayolle, Corinne; Makrerougrass, Banaouda; Dali-Yahia, Radia; Bellal, Ramdan; Belhabri, Leila; Chaieb, Amina; Tikhomirov, Evgueni; Carniel, Elisabeth

    2007-01-01

    An outbreak of plague occurred in the region of Oran, Algeria, from June to July 2003. Algeria had not reported this disease for >50 years. Eighteen bubonic cases were identified, and Yersinia pestis was isolated from 6 patients. Except for the index case-patient, all patients recovered. Targeted chemoprophylaxis, sanitation, and vector control played a crucial role in controlling the outbreak. Epidemiologic and biomolecular findings strongly suggested the existence of a local animal reservoir during this period, but its origin (resurgence or re-importation) could not be determined. This sudden and unexpected reemergence of plague, close to an important commercial seaport, is a textbook illustration of a public health event of international importance. It also demonstrates that the danger of plague reoccurrence is not limited to the currently indexed natural foci. PMID:18257987

  2. 26 CFR 1.6038-1 - Information returns required of domestic corporations with respect to annual accounting periods...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... corporations with respect to annual accounting periods of certain foreign corporations beginning before January... Information returns required of domestic corporations with respect to annual accounting periods of certain... paragraph (c) of this section, for each annual accounting period (described in paragraph (d) of this...

  3. Estimating return periods for daily precipitation extreme events over the Brazilian Amazon

    NASA Astrophysics Data System (ADS)

    Santos, Eliane Barbosa; Lucio, Paulo Sérgio; Santos e Silva, Cláudio Moisés

    2015-08-01

    This paper aims to model the occurrence of daily precipitation extreme events and to estimate the return period of these events through the extreme value theory (generalized extreme value distribution (GEV) and the generalized Pareto distribution (GPD)). The GEV and GPD were applied in precipitation series of homogeneous regions of the Brazilian Amazon. The GEV and GPD goodness of fit were evaluated by quantile-quantile (Q-Q) plot and by the application of the Kolmogorov-Smirnov (KS) test, which compares the cumulated empirical distributions with the theoretical ones. The Q-Q plot suggests that the probability distributions of the studied series are appropriated, and these results were confirmed by the KS test, which demonstrates that the tested distributions have a good fit in all sub-regions of Amazon, thus adequate to study the daily precipitation extreme event. For all return levels studied, more intense precipitation extremes is expected to occur within the South sub-regions and the coastal area of the Brazilian Amazon. The results possibly will have some practical application in local extreme weather forecast.

  4. The mental health of children upon their return home after a long displacement period.

    PubMed

    Grgić, Mirela; Vidović, Vesna; Butković-Soldo, Silva; Vuksić-Mihaljević, Zeljka; Degmecić, Dunja; Laufer, Davor

    2005-12-01

    The aim of this study was to determine the different levels of depression, hopelessness and post-traumatic stress disorder between two groups of adolescents, those who returned to Baranja and those from Osijek. The first group consisted of 57 adolescents (32 female and 25 male) with the mean age of 17.36, who were grammar school students in Beli Manastir (Gimnazija, Beli Manastir). The mean duration of displacement period was 7 years. The second group consisted of 58 adolescents of grammar school students in Osijek (III. gimnazija, Osijek) (32 female and 26 male) with the mean age of 17.28. All examinees filled in the Croatian version of the Children's Depression Inventory (CDI), the Hopelessness Scale for Children (HSC) and Children's Post-Traumatic Stress Disorder (PTSD) Inventory. The analysis of the results did not show any statistically significant difference between these two groups regarding levels of depression, hopelessness and post-traumatic stress disorder. The results point out rather good psychosocial adjustment of adolescents upon their return home after 4 years. PMID:16417158

  5. Food transitions in last 50 years and related environmental implications

    NASA Astrophysics Data System (ADS)

    Pradhan, P.; Reusser, D. E.; Kropp, J. P.

    2012-04-01

    Food production is an important driver for global change processes such as land use change and green-house-gas emissions. We analyzed a global, long term data set on food consumption per country to identify typical patterns of diets for the last 50 years. From changes in these patterns, we derived food transitions on a global scale. Subsequently we assessed the environmental consequences from green-house-gas (GHG) emission and anthropogenic inputs. More specifically, we applied Self Organizing Maps (SOM) to identify the dietary patterns based on supply of 12 food groups from FAOSTAT dataset for a period 1961-2007. Using the data on energy output/input ratio for crop production and agricultural emission, we estimated fossil energy and GHG emission associated with the diets. We found 16 typical consumption patterns consisting of high, moderate, low and lowest calorie supply with varied food compositions. The high calorie diets are associated with a higher supply of cereals, animal-products, vegetable-oils and sugar-sweeteners featuring a total supply greater than 2800 kcal/cap/day. During the last 50 years, we observed food transitions from lower calories diets to higher calories diets. On the one hand, food transition towards affluent diet, sometime with shortcuts, occurred in developing countries. On the other hand, developed countries increased consumption of fruits and vegetables. Some of the developing countries are also stagnated in the low consumption level during the last 50 years. The high calorie diets also embed higher fossil energy (1800-3500 kcal/cap/day) and are associated with higher GHG emissions (3.7-6.1 kg CO2 eq/cap/day). However, their non-CO2 GHG emission intensities per kilo calorie of food are relatively low. Changes in dietary patterns are a part of the global change processes. Identification of past transitions is way to predict possible future transitions. This in turn supports policy processes and negotiations in the fields of climate

  6. 50 years of mass balance observations at Vernagtferner, Eastern Alps

    NASA Astrophysics Data System (ADS)

    Braun, Ludwig; Mayer, Christoph

    2016-04-01

    The determination and monitoring of the seasonal and annual glacier mass balances of Vernagtferner, Austria, started in 1964 by the Commission of Glaciology, Bavarian Academy of Sciences. Detailed and continuous climate- and runoff measurements complement this mass balance series since 1974. Vernagtferner attracted the attention of scientists since the beginning of the 17th century due to its rapid advances and the resulting glacier lake outburst floods in the Ötztal valley. This is one reason for the first photogrammetric survey in 1889, which was followed by frequent topographic surveys, adding up to more than ten digital elevation models of the glacier until today. By including the known maximum glacier extent at the end of the Little Ice Age in 1845, the geodetic glacier volume balances cover a time span of almost 170 years. The 50 years of glacier mass balance and 40 years of water balance in the drainage basin are therefore embedded in a considerably longer period of glacier evolution, allowing an interpretation within an extended frame of climatology and ice dynamics. The direct mass balance observations cover not only the period of alpine-wide strong glacier mass loss since the beginning of the 1990s. The data also contain the last period of glacier advances between 1970 and 1990. The combination of the observed surface mass exchange and the determined periodic volumetric changes allows a detailed analysis of the dynamic reaction of the glacier over the period of half a century. The accompanying meteorological observations are the basis for relating these reactions to the climatic changes during this period. Vernagtferner is therefore one of the few glaciers in the world, where a very detailed glacier-climate reaction was observed for many decades and can be realistically reconstructed back to the end of the Little Ice Age.

  7. Development of a wind-gust model to estimate gust values and their return periods

    NASA Astrophysics Data System (ADS)

    Seregina, Larisa; Haas, Rabea; Born, Kai; Pinto, Joaquim G.

    2013-04-01

    Spatially dense observations of gust speeds are necessary for the validation of climate models, but the observations are limited in space and time. The use of country specific thresholds for gust reports additionally reduces the availability of gust observations. This work presents an approach to help overcome problem. The first objective of this approach is the generation of synthetic gust velocities out of distribution parameters of wind velocities. With this aim, theoretical wind and gust distributions are estimated from ten years of hourly observations made at 123 synoptic weather stations provided by the German weather service (DWD). The approach consists of three steps. In the first step, an exposure correction is applied on the measurements of the mean wind velocity to reduce the influence of local urban and topographic effects. The second step consists of linear regressions applied on the parameters of the theoretical distribution of wind and gust velocities. The regression parameters gained by this procedure are used in the third step to set a transfer function to estimate distribution parameters of the gust velocity, which are applied afterwards to estimate gust velocities. The estimated distribution parameters are validated by the use of the so-called leave-one-out method. The estimated gusts can improve the accuracy of return periods at test sites with a lack of observations. The consideration of extreme value statistics enables to obtain return periods much longer that the nominal length of the original time series. Despite of uncertainties caused by the short length of the observational records, the method leads to satisfying results.

  8. Examining Insurance Loss Return Periods with Extreme Event Intensity Thresholds across the US: 1980-2010

    NASA Astrophysics Data System (ADS)

    Smith, A. B.

    2010-12-01

    To improve the “effectiveness” of NOAA storm event information for risk managers, planners, policy makers and public safety, NOAA’s NCDC is integrating U.S. hazards/exposure data with respective insurance loss return periods. This is performed by calculating county-level extreme event intensity thresholds using these data types: hurricanes (NHC), winter storms (NESIS/RESIS), tornadoes (SPC; SWDI), hail (SPC; SWDI), high winds (SPC), drought (USDM/NIDIS), and U.S. insurance loss datasets (Munich Re, USDA-RMA, PCS, FEMA). This research also utilizes NWS warning data, socioeconomic data from the Bureau of Economic Analysis (BEA), and U.S. Census data (e.g., gridded population/density, mean housing value, per capita income, production wealth) to normalize for increases in population, inflation, and wealth. This work seeks to establish county-level U.S. extreme event economic risk climatologies for the period 1980-2010. This research will inform a new derived risk data product to improve information on extreme event loss frequencies and clustering across time and space horizons. Acronyms: FEMA: Federal Emergency Management Administration NESIS: Northeast Snowfall Impact Scale NHC: (NOAA) National Hurricane Center NIDIS: National Integrated Drought Information System PCS: Property Claim Services RESIS: Regional Snowfall Impact Scale SPC: (NOAA) Storm Prediction Center SWDI: (NOAA) Severe Weather Data Inventory USDA-RMA: U.S. Department of Agriculture - Risk Management Agency USDM: U.S. Drought Monitor

  9. Ensemble approach for projections of return periods of extreme water levels in Estonian waters

    NASA Astrophysics Data System (ADS)

    Eelsalu, Maris; Soomere, Tarmo; Pindsoo, Katri; Lagemaa, Priidik

    2014-12-01

    The contribution of various drivers to the water level in the eastern Baltic Sea and the presence of outliers in the time series of observed and hindcast water level lead to large spreading of projections of future extreme water levels. We explore the options for using an ensemble of projections to more reliably evaluate return periods of extreme water levels. An example of such an ensemble is constructed by means of fitting several sets of block maxima (annual maxima and stormy season maxima) with a Generalised Extreme Value, Gumbel and Weibull distribution. The ensemble involves projections based on two data sets (resolution of 6 h and 1 h) hindcast by the Rossby Centre Ocean model (RCO; Swedish Meteorological and Hydrological Institute) and observed data from four representative sites along the Estonian coast. The observed data are transferred into the grid cells of the RCO model using the HIROMB model and a linear regression. For coastal segments where the observations represent the offshore water level well, the overall appearance of the ensembles signals that the errors of single projections are randomly distributed and that the median of the ensemble provides a sensible projection. For locations where the observed water level involves local effects (e.g. wave set-up) the block maxima are split into clearly separated populations. The resulting ensemble consists of two distinct clusters, the difference between which can be interpreted as a measure of the impact of local features on the water level observations.

  10. Marshall Space Flight Center: 50 Years, 50 Seconds

    NASA Video Gallery

    Talk about time flying! Take a look at this super-fast review of highlights from the past 50 years at the Marshall Center. This year, Marshall is celebrating its 50th anniversary, highlighting its ...

  11. 26 CFR 1.6038-2 - Information returns required of United States persons with respect to annual accounting periods...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Information returns required of United States persons with respect to annual accounting periods of certain foreign corporations beginning after December 31, 1962. 1.6038-2 Section 1.6038-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX...

  12. 26 CFR 1.6038-1 - Information returns required of domestic corporations with respect to annual accounting periods...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Information returns required of domestic corporations with respect to annual accounting periods of certain foreign corporations beginning before January 1, 1963. 1.6038-1 Section 1.6038-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX...

  13. Rainfall erosivity and rainfall return period in the experimental watershed of Aracruz, in the Coastal Plain of Espirito Santo, Brazil

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The knowledge of the factors influencing water erosion is relevant to land management practices. Rainfall, expressed by rainfall erosivity, is very important among the factors affecting water erosion. Thus, the objective of this study was to determine rainfall erosivity and return period for the Coa...

  14. Tritium in Australian precipitation: A 50 year record

    NASA Astrophysics Data System (ADS)

    Tadros, Carol V.; Hughes, Catherine E.; Crawford, Jagoda; Hollins, Suzanne E.; Chisari, Robert

    2014-05-01

    Tritium in precipitation has been measured in Australia over the past 50 years, as an essential research tool in hydro-climate studies, and to contribute to the Global Network for Isotopes in Precipitation (GNIP). Tritium, a component of the water molecule (HTO), is the only true age tracer for waters. The elevated level of tritium in the environment as a result of last century’s atmospheric thermonuclear testing delivers the benefit of tracing groundwater systems over a 100 year timeframe. The concentration of tritium in Australian precipitation reached a maximum of 160 Tritium Units (TU) in 1963, during one of the most intense periods of nuclear weapons testing. From 1963 to present we observe a rapid drop in the concentration of tritium, more than expected from natural decay, and this can be attributed to the wash out of tritium into the oceans and groundwater. Spikes in the tritium level are superimposed over this general trend; the first around 1969, with levels ranging from 39.4 to 84.4 TU was due to French atmospheric weapon testing, and again in 1990, levels peaked between 6.6 and 12.9 TU, which is attributed to tritium leaking from underground tests in the French Pacific. Since 1990 the levels of tritium have declined globally and regionally. Currently the levels of tritium in Australia are stabilising to around 2-3 TU increasing with latitude across the continent, suggesting that today the tritium in precipitation is predominantly natural. The spatial distribution of tritium is presented and found to be dominated by the annual stratosphere-troposphere exchange in combination with latitude and continental effects. A precipitation amount effect is also observed for inland sites.

  15. The joint return period analysis of natural disasters based on monitoring and statistical modeling of multidimensional hazard factors.

    PubMed

    Liu, Xueqin; Li, Ning; Yuan, Shuai; Xu, Ning; Shi, Wenqin; Chen, Weibin

    2015-12-15

    As a random event, a natural disaster has the complex occurrence mechanism. The comprehensive analysis of multiple hazard factors is important in disaster risk assessment. In order to improve the accuracy of risk analysis and forecasting, the formation mechanism of a disaster should be considered in the analysis and calculation of multi-factors. Based on the consideration of the importance and deficiencies of multivariate analysis of dust storm disasters, 91 severe dust storm disasters in Inner Mongolia from 1990 to 2013 were selected as study cases in the paper. Main hazard factors from 500-hPa atmospheric circulation system, near-surface meteorological system, and underlying surface conditions were selected to simulate and calculate the multidimensional joint return periods. After comparing the simulation results with actual dust storm events in 54years, we found that the two-dimensional Frank Copula function showed the better fitting results at the lower tail of hazard factors and that three-dimensional Frank Copula function displayed the better fitting results at the middle and upper tails of hazard factors. However, for dust storm disasters with the short return period, three-dimensional joint return period simulation shows no obvious advantage. If the return period is longer than 10years, it shows significant advantages in extreme value fitting. Therefore, we suggest the multivariate analysis method may be adopted in forecasting and risk analysis of serious disasters with the longer return period, such as earthquake and tsunami. Furthermore, the exploration of this method laid the foundation for the prediction and warning of other nature disasters. PMID:26327640

  16. Joint return periods in hydrology: a critical and practical review focusing on the synthetic design hydrograph estimation

    NASA Astrophysics Data System (ADS)

    Vandenberghe, S.; Graeler, B.; van den Berg, M. J.; Grimaldi, S.; Petroselli, A.; De Baets, B.; Verhoest, N. E. C.

    2012-04-01

    In several branches of engineering the selection of design variables is a common exercise. Recently, there is increasing interest in considering several variables at the same time in the design, which are likely to be associated with each other. In hydrology and hydraulics, applications such as the design of sewer systems or dams, the calculation of flood risks, etc. require the selection of characteristic variables of rainfall or discharge events with a predefined return period. So far, well-established univariate frequency analysis methods have been a standard tool in practice. In contrast, newer methods show a tendency of describing hydrological phenomena with multiple variables. This is challenging practitioners to calculate the multivariate return period and to select a specific design event. In literature, several approaches for the latter problem have evolved over the years, however no study exists on how these methods compare to each other and a controversy on which approach is the right one is going on. In this study, an overview will first be given on the state of the art for defining joint return periods. The construction of multivariate distribution functions will focus on copulas, given their practicality in multivariate frequency analysis. Subsequently, a case study focusing on the selection of design hydrograph characteristics is introduced. In this application, design values of a 3-dimensional phenomenon composed of peak discharge, volume and duration are derived (for given return periods). This case study investigates and compares the different definitions of joint return periods and allows to highlight important issues with respect to multivariate frequency analysis.

  17. Effect of initial conditions and of intra-event rainfall intensity variability on shallow landslide triggering return period

    NASA Astrophysics Data System (ADS)

    Peres, David Johnny; Cancelliere, Antonino

    2016-04-01

    Assessment of shallow landslide hazard is important for appropriate planning of mitigation measures. Generally, return period of slope instability is assumed as a quantitative metric to map landslide triggering hazard on a catchment. The most commonly applied approach to estimate such return period consists in coupling a physically-based landslide triggering model (hydrological and slope stability) with rainfall intensity-duration-frequency (IDF) curves. Among the drawbacks of such an approach, the following assumptions may be mentioned: (1) prefixed initial conditions, with no regard to their probability of occurrence, and (2) constant intensity-hyetographs. In our work we propose the use of a Monte Carlo simulation approach in order to investigate the effects of the two above mentioned assumptions. The approach is based on coupling a physically based hydrological and slope stability model with a stochastic rainfall time series generator. By this methodology a long series of synthetic rainfall data can be generated and given as input to a landslide triggering physically based model, in order to compute the return period of landslide triggering as the mean inter-arrival time of a factor of safety less than one. In particular, we couple the Neyman-Scott rectangular pulses model for hourly rainfall generation and the TRIGRS v.2 unsaturated model for the computation of transient response to individual rainfall events. Initial conditions are computed by a water table recession model that links initial conditions at a given event to the final response at the preceding event, thus taking into account variable inter-arrival time between storms. One-thousand years of synthetic hourly rainfall are generated to estimate return periods up to 100 years. Applications are first carried out to map landslide triggering hazard in the Loco catchment, located in highly landslide-prone area of the Peloritani Mountains, Sicily, Italy. Then a set of additional simulations are performed

  18. It's T time: A study on the return period of multivariate problems

    NASA Astrophysics Data System (ADS)

    Michailidi, Eleni Maria; Balistrocchi, Matteo; Bacchi, Baldassare

    2016-04-01

    One of the most important tasks a hydrologist must face is the proper estimation of the 'design values' of a natural variable corresponding to a given Return Period, T, of failures of the hydraulic 'structure' to be designed or verified. Sometimes the 'structure' is simply the embankments, the failure of which corresponds to the outflows of flood runoff on the surrounding land. The widely adopted definition of T, in a problem regarding the maxima of hydrological variables, is "the average time elapsing between two successive occurrences of an event exceeding a certain magnitude of the natural variables". If T is referred to the minima, the symmetric definition pertains to the "average time between two periods during which the variable ranges below a given magnitude". Conventional (and the only accepted) approaches for estimation of T involve a single natural variable (i.e. flood-peak of a river at a given cross section, the daily maximum discharge, the maximum daily rainfall depth observed at a given rain-gauge). The method of estimation of T entails a frequency analysis of the variable of interest, where the design value of a given T is needed to design the structure of interest (e.g. dams, sewers). In other words, T is used as the index value to set the assigned risk level for the hydraulic works. However, a univariate approach in complex problems ignores the effect of significant variables interrelation leading to different risk levels for each quantity of interest and resulting in a completely wrong estimate of the risk. For example, if one considers the flood inflow in a lake around which cities and villages are positioned, the variable to be investigated in relation to the risk assessment is the lake water level. It is obvious that the same water level may occur from very different flood hydrographs, even when the same initial water level and the same rate curve of outflows are considered. This is a consequence of the interaction of at least three joint

  19. My 50 years of research in particle physics.

    PubMed

    Sugawara, Hirotaka

    2010-01-01

    Some of my work of the last 50 years in the field of theoretical particle physics is described with particular emphasis on the motivation, the process of investigation, relationship to the work of others, and its impact. My judgment is unavoidably subjective, although I do present the comments of other researchers as much as possible. PMID:20431257

  20. My 50 years of research in particle physics

    PubMed Central

    Sugawara, Hirotaka

    2010-01-01

    Some of my work of the last 50 years in the field of theoretical particle physics is described with particular emphasis on the motivation, the process of investigation, relationship to the work of others, and its impact. My judgment is unavoidably subjective, although I do present the comments of other researchers as much as possible. PMID:20431257

  1. An opportune life: 50 years in human cytogenetics.

    PubMed

    Jacobs, Patricia A

    2014-01-01

    This article is one person's view of human cytogenetics over the past 50 years. The flowering of human cytogenetics led the way to the establishment of clinical genetics as one of the most important developments in medicine in the twentieth century. The article is written from the viewpoint of a scientist who never tired of analyzing the images of dividing cells on the light microscope and interpreting the wealth of information contained in them. PMID:25184528

  2. Canadian medical education: 50 years of innovation and leadership.

    PubMed

    Dauphinee, W D

    1993-05-01

    Over the past 50 years, many Canadian medical educators have pursued ideas and visions, as individuals in the 1950s and 1960s and later in partnership with various national bodies. Relations between universities and national medical organizations have been productive in dealing with issues of postgraduate education and clinical assessment, in particular. From 1970 to 1990, strong education offices and formally trained educators led to many successes in the areas of research in cognition, continuing medical education and clinical assessment. Canadian medical education has now achieved international recognition for its work in all aspects of the continuum of the physician's education through vision, initiative and cooperation. PMID:8477386

  3. Flavor Physics and Nagoya --- The Past 50 Years

    NASA Astrophysics Data System (ADS)

    Sanda, A. I.

    In this talk, I briefly review how Nagoya physics has contributed tothe development of flavor physics over the past 50 years. It began with the introduction of Sakata model back in 1956, and recently it contributed to the discovery of CP violation in 2000. Along the way Kobayashi and Maskawa completed the standard model by introducing the KM ansatz for CP violation. We shall also describe two discoveries by Nagoya emulsion group made before 1990: (1) the first evidence for the charm quark; (2) discovery of the D(0) and D(+) mesons.

  4. Trading and non-trading period Internet information flow and intraday return volatility

    NASA Astrophysics Data System (ADS)

    Shen, Dehua; Zhang, Wei; Xiong, Xiong; Li, Xiao; Zhang, Yongjie

    2016-06-01

    This paper employs the news appeared in Baidu News as the proxy for Internet information flow, separates them into trading period and non-trading period information and provides alternative evidence for the Mixture of Distribution Hypothesis (MDH). The empirical results show that the contemporary information can effectively reduce the volatility persistence; meanwhile, the lead information and the aggregate information also show some explanatory power. Some future directions are pointed out in the concluding remarks.

  5. Toward the second 50 years of Water Resources Research

    NASA Astrophysics Data System (ADS)

    Rajaram, H.

    2014-12-01

    Since the first issue in 1965, 49 volumes and 464 issues of Water Resources Research (WRR) have been published, including more than 13,800 contributions that received more than 380,000 citations. WRR has always maintained a forward-looking vision, providing an interdisciplinary platform to nurture the initiation and development of numerous sub-disciplines and research themes in hydrology, water resources, and earth sciences and over the last 50 years. This vision, supported in no small measure by a dedicated community of researchers who submitted their best research to WRR, have helped the journal maintain its international leadership in this field. As we enter the second 50 years of WRR, new trends in scientific publishing, open access publication and web-based discussion forums, pose challenges (and opportunities) for sustaining WRR's leadership role. In this presentation, we will present the vision of the present editorial board for the future of WRR, and discuss several steps we are undertaking to adapt the journal to modern trends in communicating scientific research. This includes the introduction of new article types, such as the forthcoming "Debates on Water Resources", targeted special sections, and efforts to improve the timeliness of the review process. We humbly stand on the shoulders of the thirty-four dedicated previous editors of WRR, and remain open to receiving suggestions from the AGU hydrologic community.

  6. [50 years of hepatology - from therapeutic nihilism to targeted therapies].

    PubMed

    Manns, Michael P

    2013-04-01

    Over the past 50 years significant progress has been made in the whole field of hepatology. Part of this is translation of basic research (biochemistry, immunology, virology, molecular biology and others) into clinical hepatology. This enabled us to understand more about the pathogenesis of liver diseases and led to the discovery of the five major hepatotropic viruses, the identification of hepatocellular autoantigens, and to the development of specific therapies for chronic hepatitis B, C and D. In addition, the molecular basis of most genetic liver diseases has been identified. Significant progress was made in the development of medical therapies for various liver diseases with different underlying etiologies. Surgery significantly contributed to the progress in the management of liver diseases; examples are laparoscopic cholecystectomy and the development of liver transplantation. A multimodal therapeutic algorithm has been established for the therapy of hepatocelluar carcinoma (HCC); with Sorafenib "targeted therapy" has entered the area of HCC. The progress made over the last 50 years not only led to an aetiological differentiation of acute and chronic liver diseases but also to specific therapies based on the identification and understanding of the underlying etiology. PMID:23585265

  7. Should Age-Period-Cohort Studies Return to the Methodologies of the 1970s?

    PubMed Central

    Masters, Ryan K.; Yang, Y. Claire; Powers, Daniel A.; Zheng, Hui; Land, Kenneth C.

    2015-01-01

    Social scientists have recognized the importance of age-period-cohort (APC) models for half a century, but have spent much of this time mired in debates about the feasibility of APC methods. Recently, a new class of APC methods based on modern statistical knowledge has emerged, offering potential solutions. In 2009, Reither, Hauser and Yang used one of these new methods – hierarchical APC (HAPC) modeling – to study how birth cohorts may have contributed to the U.S. obesity epidemic. They found that recent birth cohorts experience higher odds of obesity than their predecessors, but that ubiquitous period-based changes are primarily responsible for the rising prevalence of obesity. Although these findings have been replicated elsewhere, recent commentaries by Bell and Jones call them into question – along with the new class of APC methods. Specifically, Bell and Jones claim that new APC methods do not adequately address model identification and suggest that “solid theory” is often sufficient to remove one of the three temporal dimensions from empirical consideration. They also present a series of simulation models that purportedly show how the HAPC models estimated by Reither et al. (2009) could have produced misleading results. However, these simulation models rest on assumptions that there were no period effects, and associations between period and cohort variables and the outcome were perfectly linear. Those are conditions under which APC models should never be used. Under more tenable assumptions, our own simulations show that HAPC methods perform well, both in recovering the main findings presented by Reither et al. (2009) and the results reported by Bell and Jones. We also respond to critiques about model identification and theoretically-imposed constraints, finding little pragmatic support for such arguments. We conclude by encouraging social scientists to move beyond the debates of the 1970s and toward a deeper appreciation for modern APC

  8. The triple helix: 50 years later, the outcome

    PubMed Central

    Duca, Maria; Vekhoff, Pierre; Oussedik, Kahina; Halby, Ludovic; Arimondo, Paola B.

    2008-01-01

    Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a chosen site on the DNA. They are not only used as biotechnological tools but also to induce modifications on DNA with the aim to control gene expression, such as by site-directed mutagenesis or DNA recombination. Here, we report the state of art of the triplex-based anti-gene strategy 50 years after the discovery of such a structure, and we show the importance of the actual applications and the main challenges that we still have ahead of us. PMID:18676453

  9. 50 years of CP violation — What have we learned?

    SciTech Connect

    McKellar, Bruce H. J.

    2015-04-24

    Early after the discovery of CP violation, the explanation of how the Standard Model of particle physics could allow CP violation was quickly given, but it took many years for the original observation to be unequivocally explained on that basis. It was also proposed that this observation opened up the possibility that we could now explain the fact that the universe is made of matter. Remarkably, 50 years later we have no evidence in particle physics that there is any CP violation except that of the Kobayashi Maskawa mechanism of the standard model. Yet we fail completely to explain the baryon asymmetry of the Universe through that mechanism. After reviewing the main points in the history I describe the present experimental attempts to find CP violation beyond the standard model, and explain the theoretical attempts to explain the matter in the Universe.

  10. [Molecular bases of cellular senescence: Hayflick phenomenon 50 years later].

    PubMed

    Sosińska, Patrycja; Mikuła-Pietrasik, Justyna; Książek, Krzysztof

    2016-01-01

    Normal human somatic cells have strictly limited proliferative capacity and reach a state of senescence when it becomes exhausted. It is believed that senescence is a response to extensive and irreparable DNA injury, localized in telomeric and/or non-telomeric regions of the genome. Main cause of this damage is oxidative stress, increasing due to deteriorated function of mitochondria. Senescent cells accumulate in tissues during aging, which is causatively linked with the development of various pathologies in elderly individuals, including cancer. This paper, prepared exactly 50 years after Leonard Hayflick's discovery of the relationship between cellular senescence and organismal aging is aimed at presenting the current knowledge about molecular determinants of senescence, with particular emphasis paid to the role of oxidative stress, effectors of senescence at the level of cell cycle, markers of this phenomenon, and the effect of senescent cells on the development of certain age-related diseases. PMID:27117098

  11. 26 CFR 1.6038-1 - Information returns required of domestic corporations with respect to annual accounting periods...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... provisions of this section, any return or any information in any return, required to be filed for a taxable... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Information returns required of domestic... TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Information Returns §...

  12. Comparison of 50-year and 70-year internal-dose-conversion factors

    SciTech Connect

    Ryan, M.T.; Dunning, D.E. Jr.

    1981-03-01

    The 50-year inhalation and ingestion dose commitments associated with an acute intake (of a radionuclide) of 3.7 x 10/sup 4/ Bq (1 ..mu..Ci) in one day were compared with the corresponding dose commitments calculated for a 70-year integration period resulting from a chronic intake of the same amount at a rate of 101 Bq/d (0.00274 ..mu..Ci/d) for one year. These values, known as dose conversion factors, estimate the dose accumulated during a given period of time following a unit of intake of a radionuclide. It was demonstrated that the acute intake of 3.7 x 10/sup 4/ Bq in one day and the chronic intake of 101 Bq/d for one year (a total intake of 3.7 x 10/sup 4/ Bq) result in essentially the same dose commitment for a relatively long integration period. Therefore, the comparison of 50-year acute dose conversion factors and 70-year chronic dose conversion factors is essentially only a measure of the additional dose accumulated in the 50 to 70 year period. It was found that for radionuclides with atomic mass less than 200 the percent difference in the 70-year and 50-year dose conversion factors was essentially zero in most cases. Differences of approximately 5 to 50% were obtained for dose conversion factors for most alpha emitters with atomic masses of greater than 200. Comparisons were made on the basis of both organ dose equivalent and effective dose equivalent. The implications and significance of these results are discussed.

  13. Has adult sleep duration declined over the last 50+ years?

    PubMed

    Youngstedt, Shawn D; Goff, Eric E; Reynolds, Alexandria M; Kripke, Daniel F; Irwin, Michael R; Bootzin, Richard R; Khan, Nidha; Jean-Louis, Girardin

    2016-08-01

    The common assumption that population sleep duration has declined in the past few decades has not been supported by recent reviews, which have been limited to self-reported data. The aim of this review was to assess whether there has been a reduction in objectively recorded sleep duration over the last 50+ years. The literature was searched for studies published from 1960 to 2013, which assessed objective sleep duration (total sleep time (TST)) in healthy normal-sleeping adults. The search found 168 studies that met inclusion criteria, with 257 data points representing 6052 individuals ages 18-88 y. Data were assessed by comparing the regression lines of age vs. TST in studies conducted between 1960 and 1989 vs. 1990-2013. Weighted regression analyses assessed the association of year of study with age-adjusted TST across all data points. Regression analyses also assessed the association of year of study with TST separately for 10-y age categories (e.g., ages 18-27 y), and separately for polysomnographic and actigraphic data, and for studies involving a fixed sleep schedule and participants' customary sleep schedules. Analyses revealed no significant association of sleep duration with study year. The results are consistent with recent reviews of subjective data, which have challenged the notion of a modern epidemic of insufficient sleep. PMID:26478985

  14. A Dynamic Earth: 50 Years of Observations from Space

    NASA Technical Reports Server (NTRS)

    Evans, Cynthia A.

    2013-01-01

    Observations of the surface of the Earth began more than a half century ago with the earliest space missions. The global geopolitical environment at the beginning of the space age fueled advances in rocketry and human exploration, but also advances in remote sensing. At the same time that space-based Earth Observations were developing, global investments in infrastructure that were initiated after World War II accelerated large projects such as the construction of highways, the expansion of cities and suburbs, the damming of rivers, and the growth of big agriculture. These developments have transformed the Earth s surface at unprecedented rates. Today, we have a remarkable library of 50 years of observations of the Earth taken by satellite-based sensors and astronauts, and these images and observations provide insight into the workings of the Earth as a system. In addition, these observations record the footprints of human activities around the world, and illustrate how our activities contribute to the changing face of the Earth. Starting with the iconic "Blue Marble" image of the whole Earth taken by Apollo astronauts, we will review a timeline of observations of our planet as viewed from space.

  15. 50 years of computer simulation of the human thermoregulatory system.

    PubMed

    Hensley, Daniel W; Mark, Andrew E; Abella, Jayvee R; Netscher, George M; Wissler, Eugene H; Diller, Kenneth R

    2013-02-01

    This paper presents an updated and augmented version of the Wissler human thermoregulation model that has been developed continuously over the past 50 years. The existing Fortran code is translated into C with extensive embedded commentary. A graphical user interface (GUI) has been developed in Python to facilitate convenient user designation of input and output variables and formatting of data presentation. Use of the code with the GUI is described and demonstrated. New physiological elements were added to the model to represent the hands and feet, including the unique vascular structures adapted for heat transfer associated with glabrous skin. The heat transfer function and efficacy of glabrous skin is unique within the entire body based on the capacity for a very high rate of blood perfusion and the novel capability for dynamic regulation of blood flow. The model was applied to quantify the absolute and relative contributions of glabrous skin flow to thermoregulation for varying levels of blood perfusion. The model also was used to demonstrate how the unique features of glabrous skin blood flow may be recruited to implement thermal therapeutic procedures. We have developed proprietary methods to manipulate the control of glabrous skin blood flow in conjunction with therapeutic devices and simulated the effect of these methods with the model. PMID:23445051

  16. Conformational selection or induced fit? 50 years of debate resolved

    PubMed Central

    Edelstein, Stuart

    2011-01-01

    Exactly 50 years ago, biochemists raised the question of the mechanism of the conformational change that mediates “allosteric” interactions between regulatory sites and biologically active sites in regulatory/receptor proteins. Do the different conformations involved already exist spontaneously in the absence of the regulatory ligands (Monod-Wyman-Changeux), such that the complementary protein conformation would be selected to mediate signal transduction, or do particular ligands induce the receptor to adopt the conformation best suited to them (Koshland-Nemethy-Filmer—induced fit)? This is not just a central question for biophysics, it also has enormous importance for drug design. Recent advances in techniques have allowed detailed experimental and theoretical comparisons with the formal models of both scenarios. Also, it has been shown that mutated receptors can adopt constitutively active confirmations in the absence of ligand. There have also been demonstrations that the atomic resolution structures of the same protein are essentially the same whether ligand is bound or not. These and other advances in past decades have produced a situation where the vast majority of the data using different categories of regulatory proteins (including regulatory enzymes, ligand-gated ion channels, G protein-coupled receptors, and nuclear receptors) support the conformational selection scheme of signal transduction. PMID:21941598

  17. Approved Antiviral Drugs over the Past 50 Years.

    PubMed

    De Clercq, Erik; Li, Guangdi

    2016-07-01

    Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs categorized into 13 functional groups have been formally approved for the treatment of the following 9 human infectious diseases: (i) HIV infections (protease inhibitors, integrase inhibitors, entry inhibitors, nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and acyclic nucleoside phosphonate analogues), (ii) hepatitis B virus (HBV) infections (lamivudine, interferons, nucleoside analogues, and acyclic nucleoside phosphonate analogues), (iii) hepatitis C virus (HCV) infections (ribavirin, interferons, NS3/4A protease inhibitors, NS5A inhibitors, and NS5B polymerase inhibitors), (iv) herpesvirus infections (5-substituted 2'-deoxyuridine analogues, entry inhibitors, nucleoside analogues, pyrophosphate analogues, and acyclic guanosine analogues), (v) influenza virus infections (ribavirin, matrix 2 protein inhibitors, RNA polymerase inhibitors, and neuraminidase inhibitors), (vi) human cytomegalovirus infections (acyclic guanosine analogues, acyclic nucleoside phosphonate analogues, pyrophosphate analogues, and oligonucleotides), (vii) varicella-zoster virus infections (acyclic guanosine analogues, nucleoside analogues, 5-substituted 2'-deoxyuridine analogues, and antibodies), (viii) respiratory syncytial virus infections (ribavirin and antibodies), and (ix) external anogenital warts caused by human papillomavirus infections (imiquimod, sinecatechins, and podofilox). Here, we present for the first time a comprehensive overview of antiviral drugs approved over the past 50 years, shedding light on the development of effective antiviral treatments against current and emerging infectious diseases worldwide. PMID:27281742

  18. 50 years of space science (Jean Dominique Cassini Medal Lecture)

    NASA Astrophysics Data System (ADS)

    Bonnet, Roger-Maurice

    2013-04-01

    The launch of Sputnik-1 triggered my fascination for space at the age of 20. The past 50 years have allowed me to study the Sun with sounding rockets and satellites, revealing the complexity of our star, contributing to the understanding of its physics, and offering surprising manifestations of its behavior and of its effects on Earth. Building instruments for space astronomy, managing teams of space scientists and engineers, led me to become the science director of the European space agency between 1983 and 2001 where I formulated and managed the Horizon 2000 program, which led Europe to occupy the front row of world space science. The Jean Dominique Cassini Medal Lecture offers me an opportunity, to describe the most spectacular achievements of this long-term plan and to outline some basic principles for reaching success, including the essential role of international cooperation with shared partnership. The Lecture also identifies key problems and controversial issues that space astronomy and exploration will face in the 21st century.

  19. 50 years of hurdles and hope in anxiolytic drug discovery

    PubMed Central

    Griebel, Guy; Holmes, Andrew

    2014-01-01

    Anxiety disorders are the most prevalent group of psychiatric diseases, and have high personal and societal costs. The search for novel pharmacological treatments for these conditions is driven by the growing medical need to improve on the effectiveness and the side effect profile of existing drugs. A huge volume of data has been generated by anxiolytic drug discovery studies, which has led to the progression of numerous new molecules into clinical trials. However, the clinical outcome of these efforts has been disappointing, as promising results with novel agents in rodent studies have very rarely translated into effectiveness in humans. Here, we analyse the major trends from preclinical studies over the past 50 years conducted in the search for new drugs beyond those that target the prototypical anxiety-associated GABA (γ-aminobutyric acid)–benzodiazepine system, which have focused most intensively on the serotonin, neuropeptide, glutamate and endocannabinoid systems. We highlight various key issues that may have hampered progress in the field, and offer recommendations for how anxiolytic drug discovery can be more effective in the future. PMID:23989795

  20. Aflatoxin: A 50-Year Odyssey of Mechanistic and Translational Toxicology

    PubMed Central

    Kensler, Thomas W.; Roebuck, Bill D.; Wogan, Gerald N.; Groopman, John D.

    2011-01-01

    Since their discovery 50 years ago, the aflatoxins have become recognized as ubiquitous contaminants of the human food supply throughout the economically developing world. The adverse toxicological consequences of these compounds in populations are quite varied because of a wide range of exposures leading to acute effects, including rapid death, and chronic outcomes such as hepatocellular carcinoma. Furthermore, emerging studies describe a variety of general adverse health effects associated with aflatoxin, such as impaired growth in children. Aflatoxin exposures have also been demonstrated to multiplicatively increase the risk of liver cancer in people chronically infected with hepatitis B virus (HBV) illustrating the deleterious impact that even low toxin levels in the diet can pose for human health. The public health impact of aflatoxin exposure is pervasive. Aflatoxin biomarkers of internal and biologically effective doses have been integral to the establishment of the etiologic role of this toxin in human disease through better estimates of exposure, expanded knowledge of the mechanisms of disease pathogenesis, and as tools for implementing and evaluating preventive interventions. PMID:20881231

  1. Why the 1964 Great Alaska Earthquake matters 50 years later

    USGS Publications Warehouse

    West, Michael E.; Haeussler, Peter J.; Ruppert, Natalia A.; Freymueller, Jeffrey T.; Alaska Seismic Hazards Safety Commission

    2014-01-01

    Spring was returning to Alaska on Friday 27 March 1964. A two‐week cold snap had just ended, and people were getting ready for the Easter weekend. At 5:36 p.m., an earthquake initiated 12 km beneath Prince William Sound, near the eastern end of what is now recognized as the Alaska‐Aleutian subduction zone. No one was expecting this earthquake that would radically alter the coastal landscape, influence the direction of science, and indelibly mark the growth of a burgeoning state.

  2. A system for generating long streamflow records for study of floods of long return period: Phase 2

    SciTech Connect

    Franz, D.D.; Kraeger, B.A.; Linsley, R.K.

    1989-02-01

    Knowledge of the return periods of large floods is required to make risk analyses for nuclear power plants subject to flooding from rivers. The system reported here combined the stochastic simulation of hourly rainfall data and daily pan evaporation data with the deterministic simulation of streamflow by using the synthetic rainfall and evaporation data as input to a calibrated rainfall runoff model. The sequence of annual maximum flood peaks from a synthetic record of 10,000 years or more was then analyzed to obtain estimates of flood frequency. The reasonableness of the flood frequency results must be evaluated on the degree of mimicry of the key characteristics of the observed rainfall data and the ability of the rainfall-runoff model to mimic the observed flood frequency during the calibration period. On this basis, the flood frequency results appeared to be a reasonable extrapolation of the data used in defining the model parameters. There is a need to develop regional parameters for the stochastic models and to conduct research on the relationship between the stochastic structure of rainfall and stochastic structure of flood frequency. The methodology is applicable, assuming a highly skilled analyst, to watersheds similar to those already tested.

  3. Geochemical Diversity of the Mantle: 50 Years of Acronyms

    NASA Astrophysics Data System (ADS)

    Hart, S. R.

    2014-12-01

    50 years ago, Gast, Tilton and Hedge demonstrated that the oceanic mantle is isotopically heterogeneous. 28 years ago, Zindler and Hart formalized the concept of geochemical mantle components, with an attendant, to some, odious, acronym soup. Work on a marriage of mantle geochemistry and dynamics continues unabated. We know unequivocally that the mantle is chemically heterogeneous; we do not know the scale lengths of these heterogeneities. We know unequivocally that these heterogeneities have persisted for eons (Gy); we do not know where they were formed or where they are stored. Through the kind auspices of the Plume Model, we plausibly have access to the whole mantle. The most accessible and well understood mantle reservoir is the upper depleted MORB mantle (DMM). Classically, this mantle was depleted by extraction of oceanic and continental crust from a "chondritic" bulk silicate Earth. In this post-Boyet and Carlson world, the complementary enriched reservoir may instead be hidden in the deepest mantle. In this case, DMM will become an endangered acronym. Hofmann and White (1982) argued that radiogenic Pb mantle (HIMU) is re-cycled ocean crust, and this is a comfortably viable model. It does require some ad hoc chemical manipulations during subduction. Given 2 Gy of aggregate mantle strains, the mafic component in HIMU may be of small length scale (< 50 m), possibly subsumed into the dominant peridotitic lithology. This mantle species is globally widespread. Enriched mantles (EM1 and EM2) almost certainly reflect recycling of enriched continental material. This was splendidly verified by Jackson et al (2007), with 87Sr/86Sr in Samoan EM2 lavas up to 0.721. The lithology and length scale of EM1 and EM2 is unconstrained. EM1 is globally present; EM2 is confined to the SW Pacific hotspots. FOZO is a work in progress; many would like to see it become extinct! The trace element signatures of HIMU and FOZO mantles have been constrained using melting models; in both

  4. Backwards and Forwards: 50 years of the Education Group

    NASA Astrophysics Data System (ADS)

    2000-01-01

    by representatives from a number of equally prestigious universities. In one, the large physics lecture rooms were taken over by philosophy students, as smaller physics groups traipsed across to distant biology rooms. It was this kind of situation, plus the reduction in the level of technician support, that made demonstrations harder to organize. In the lively discussion that followed Professor Brown's talk there was strong support for his proposal that universities - with the help of the IoP and the Royal Society, say - should set up a national `demonstration bank' that could be tapped to provide portable, well-tried, well-resourced and well-rehearsed demonstrations. Envy was expressed for the bank of experiments and demonstrations available at school level, especially as presented by the Advancing Physics CD-ROM. Universities could also learn from the course designs exemplified by Advancing Physics and the York Salters Horners projects: a set of self-contained, coherent topics with clear end-points and built-in mathematics, with key concepts well-illustrated by relevant experiments. The final session was given by Ken Dobson, who had the onerous but luckily uncheckable task of talking about Physics education: the next 50 years! (organizer's emphasis). In less than 15 minutes he expressed his complete incompetence at carrying out such a task, but in spite of that went on to compare the current state of progress (leading to an unfortunate state of dystopia) with what he thought should happen (leading to a much happier state of utopia). The key differences were the current over-centralization, mechanistic and top-down direction of education based on a system-centred command-psychology, as compared with an organic, self-directed, learner-centred education. He called the first dystopian model the Rucsac Model : everything you needed for life had to be packed by the time you left school, and should serve you all your days. By contrast, he called the utopian future a

  5. 26 CFR 1.6694-4 - Extension of period of collection when tax return preparer pays 15 percent of a penalty for...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Extension of period of collection when tax return preparer pays 15 percent of a penalty for understatement of taxpayer's liability and certain other procedural matters. 1.6694-4 Section 1.6694-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX...

  6. Assessing the potential impacts of climate change on return periods of hydrological extremes in the Illinois River watershed of the Midwestern United States

    NASA Astrophysics Data System (ADS)

    Chien, H.; Yeh, P. J. F.; Knouft, J.

    2014-12-01

    As the Earth's climate is predicted to change significantly in terms of warmer temperature and higher precipitation extremes during this century due to the increased combustion of fossil fuels, accurate estimations of the frequencies of future hydrological extremes are important to understanding the potential impacts of changes in climate on water resources management, particularly in accessing flood risk. The goal of this study is to use the Soil and Water Assessment Tool (SWAT), a distributed landscape-scale hydrological model, to predict current streamflow and the potential impacts of climate change on future stream flows in the Illinois River watershed in the Midwestern United States. Subsequently Gumbel distribution (Extreme Value Type Ⅰ) is fitted to the annual maxima simulated streamflow to derive a number of return periods of future hydrological extremes. The question in this study is: How do the return periods of future hydrological extremes change under future climate change scenarios and what factors cause the change? Daily simulated future streamflow from 2046-2065 and 2081-2100 are simulated using SWAT model based on nine separate downscaled global climate models (GCM) with three emissions scenarios. SWAT model predictions generally indicate that annual streamflow will likely decrease due to warmer temperatures. Based on the simulated daily streamflow, probability models for annual maxima flows frequency analysis are developed using Gumbel distribution and the values of hydrological extremes for different return periods including 50, 100, 200, 500, 1000 years are derived. The change of return periods of hydrological extremes and the implications will be discussed.

  7. 20 CFR 1002.236 - How is the employee's rate of pay determined when he or she returns from a period of service?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false How is the employee's rate of pay determined when he or she returns from a period of service? 1002.236 Section 1002.236 Employees' Benefits OFFICE OF THE ASSISTANT SECRETARY FOR VETERANS' EMPLOYMENT AND TRAINING SERVICE, DEPARTMENT OF LABOR REGULATIONS UNDER THE UNIFORMED SERVICES...

  8. 26 CFR 1.6038-2 - Information returns required of United States persons with respect to annual accounting periods...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... establishes to the satisfaction of the district director or the director of the service center that the person... respect to which a return is filed, include banking transactions entered into on behalf of customers;...

  9. Patellar tendon or hamstring graft anterior cruciate ligament reconstructions in patients aged above 50 years

    PubMed Central

    Bali, Tarun; Nagraj, Raghu; Kumar, Malhar N; Chandy, Thomas

    2015-01-01

    Background: The treatment of anterior cruciate ligament (ACL) injury consists of arthroscopic ACL reconstruction with patellar tendon or hamstring graft. Satisfactory results have been reported so far in the younger age group. Dilemma arises regarding the suitability of ACL reconstruction in patients aged 50 years and above. This retrospective analyses the outcome of ACL reconstruction in patients aged 50 years and above. Materials and Methods: 55 patients aged 50 years and above presented to our institution with symptomatic ACL tear and were managed with arthroscopic reconstruction with patellar tendon/hamstring graft. 22 patients underwent ACL reconstruction with bone- patellar tendon-bone graft and the remaining 33 with a hamstring graft. Evaluation of functional outcome was performed using International Knee Documentation Committee (IKDC) and Lysholm scoring in the preoperative period, at the end of 1 year and at the final followup. Radiographic evaluation was performed using the Kellgren–Lawrence grading system. Results: The mean preoperative IKDC score was 39.7 ± 3.3. At the end of 1-year following the operation, the mean IKDC score was 73.6 ± 4.9 and at the final followup was 67.8 ± 7.7. The mean preoperative Lysholm score was 40.4 ± 10.3. At the end of 1-year following the intervention, the mean Lysholm score was 89.7 ± 2.1 and at final followup was 85.3 ± 2.5. Overall, 14 out of 42 patients who underwent radiographic assessment showed progression of osteoarthritis changes at the final followup after the intervention. Conclusion: In our study, there was a statistically significant improvement in the IKDC and Lysholm scores following the intervention. There was a slight deterioration in the scores at the final followup but the overall rate of satisfaction was still high and most of the patients were able to do their routine chores and light exercises suitable for their age group. Around one-third of patients show progression of radiographic changes

  10. How the World Survived the Population Bomb: Lessons From 50 Years of Extraordinary Demographic History

    PubMed Central

    Lam, David

    2012-01-01

    The world population will reach 7 billion in late 2011, a demographic milestone that is causing renewed attention to the challenges caused by population growth. This article looks at the last 50 years of demographic change, one of the most extraordinary periods in demographic history. During this period, world population grew at rates that have never been seen before and will almost surely never be seen again. There were many concerns about the potential impact of rapid population growth in the 1960s, including mass starvation in countries such as India, depletion of nonrenewable resources, and increased poverty in low-income countries. The actual experience was very different. World food production increased faster than world population in every decade since the 1960s, resource prices fell during most of the period, and poverty declined significantly in much of the developing world. The article considers the economic and demographic explanations for the surprising successes of this important period in demographic history. It also looks at regions that have been less successful, especially Africa, and at the lessons for dealing with the important challenges that still remain. PMID:22005884

  11. Morphological changes of Gumara River channel over 50 years, upper Blue Nile basin, Ethiopia

    NASA Astrophysics Data System (ADS)

    Abate, Mengiste; Nyssen, Jan; Steenhuis, Tammo S.; Moges, Michael M.; Tilahun, Seifu A.; Enku, Temesgen; Adgo, Enyew

    2015-06-01

    In response to anthropogenic disturbances, alluvial rivers adjust their geometry. The alluvial river channels in the upper Blue Nile basin have been disturbed by human-induced factors since a longtime. This paper examines channel adjustment along a 38-km stretch of the Gumara River which drains towards Lake Tana and then to the Blue Nile. Over a 50 years period, agriculture developed rapidly in the catchment and flooding of the alluvial plain has become more frequent in recent times. The objectives of this study were to document the changes in channel planform and cross-section of the Gumara River and to investigate whether the changes could have contributed to the frequent flooding or vice versa. Two sets of aerial photographs (1957 and 1980) were scanned, and then orthorectified. Recent channel planform information was extracted from SPOT images of 2006 and Google Earth. Channel planform and bed morphology (vertical changes) were determined for these nearly 50 years period. The vertical changes were determined based on aggradation along a permanent structure, historic information on river cross-sections at a hydrological gauging station, and field observations. The results indicate that the lower reach of Gumara near its mouth has undergone major planform changes. A delta with approx. 1.12 km2 of emerged land was created between 1957 and 1980 and an additional 1 km2 of land has been added between 1980 and 2006. The sinuosity of the river changed only slightly: negatively (-1.1% i.e. meandering decreased) for the period from 1957 to 1980 and positively (+3.0%) for the period 1980-2006. Comparison of cross-sections at the hydrological gauging station showed that the deepest point in the river bed aggraded by 2.91 m for the period 1963-2009. The importance of sediment deposition in the stream and on its banks is related to land degradation in the upper catchment, and to artificial rising of Lake Tana level that creates a backwater effect and sediment deposition in

  12. 26 CFR 1.6038-2 - Information returns required of United States persons with respect to annual accounting periods...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 13 2011-04-01 2011-04-01 false Information returns required of United States... 31, 1962. 1.6038-2 Section 1.6038-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... foreign corporation. A person in control of a corporation which, in turn, owns more than 50 percent of...

  13. 26 CFR 1.6038-2 - Information returns required of United States persons with respect to annual accounting periods...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Information returns required of United States... 31, 1962. 1.6038-2 Section 1.6038-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... foreign corporation. A person in control of a corporation which, in turn, owns more than 50 percent of...

  14. 26 CFR 1.6038-2 - Information returns required of United States persons with respect to annual accounting periods...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Information returns required of United States... 31, 1962. 1.6038-2 Section 1.6038-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... foreign corporation. A person in control of a corporation which, in turn, owns more than 50 percent of...

  15. Modified Methodology for Projecting Coastal Louisiana Land Changes over the Next 50 Years

    USGS Publications Warehouse

    Hartley, Steve B.

    2009-01-01

    The coastal Louisiana landscape is continually undergoing geomorphologic changes (in particular, land loss); however, after the 2005 hurricane season, the changes were intensified because of Hurricanes Katrina and Rita. The amount of land loss caused by the 2005 hurricane season was 42 percent (562 km2) of the total land loss (1,329 km2) that was projected for the next 50 years in the Louisiana Coastal Area (LCA), Louisiana Ecosystem Restoration Study. The purpose of this study is to provide information on potential changes to coastal Louisiana by using a revised LCA study methodology. In the revised methodology, we used classified Landsat TM satellite imagery from 1990, 2001, 2004, and 2006 to calculate the 'background' or ambient land-water change rates but divided the Louisiana coastal area differently on the basis of (1) geographic regions ('subprovinces') and (2) specific homogeneous habitat types. Defining polygons by subprovinces (1, Pontchartrain Basin; 2, Barataria Basin; 3, Vermilion/Terrebonne Basins; and 4, the Chenier Plain area) allows for a specific erosion rate to be applied to that area. Further subdividing the provinces by habitat type allows for specific erosion rates for a particular vegetation type to be applied. Our modified methodology resulted in 24 polygons rather than the 183 that were used in the LCA study; further, actively managed areas and the CWPPRA areas were not masked out and dealt with separately as in the LCA study. This revised methodology assumes that erosion rates for habitat types by subprovince are under the influence of similar environmental conditions (sediment depletion, subsidence, and saltwater intrusion). Background change rate for three time periods (1990-2001, 1990-2004, and 1990-2006) were calculated by taking the difference in water or land among each time period and dividing it by the time interval. This calculation gives an annual change rate for each polygon per time period. Change rates for each time period

  16. Biogeochemical control of marine productivity in the Mediterranean Sea during the last 50 years

    PubMed Central

    Macias, Diego; Garcia-Gorriz, Elisa; Piroddi, Chiara; Stips, Adolf

    2014-01-01

    The temporal dynamics of biogeochemical variables derived from a coupled 3-D model of the Mediterranean Sea are evaluated for the last 50 years (1960–2010) against independent data on fisheries catch per unit effort (CPUE) for the same time period. Concordant patterns are found in the time series of all of the biological variables (from the model and from fisheries statistics), with low values at the beginning of the series, a later increase, with maximum levels reached at the end of the 1990s, and a posterior stabilization. Spectral analysis of the annual biological time series reveals coincident low-frequency signals in all of them. The first, more energetic signal peaks around the year 2000, while the second, less energetic signal peaks near 1982. Almost identical low-frequency signals are found in the nutrient loads of the rivers and in the integrated nutrient levels in the surface marine ecosystem. Nitrate concentration shows a maximum level in 1998, with a later stabilization to present-day values, coincident with the first low-frequency signal found in the biological series. Phosphate shows maximum concentrations around 1982 and a posterior sharp decline, in concordance with the second low-frequency signal observed in the biological series. That result seems to indicate that the control of marine productivity (plankton to fish) in the Mediterranean is principally mediated through bottom-up processes that could be traced back to the characteristics of riverine discharges. The high sensitivity of CPUE time series to environmental conditions might be another indicator of the overexploitation of this marine ecosystem. Key Points Biogeochemical evolution of the Mediterranean over the past 50 years River nutrient loads drive primary and secondary productions Strong link between low trophic levels and fisheries PMID:26180286

  17. Social Network Analysis of 50 Years of International Collaboration in the Research of Educational Technology

    ERIC Educational Resources Information Center

    Guo, Shesen; Zhang, Ganzhou; Guo, Yufei

    2016-01-01

    The definition of the field of educational technology has evolved over 50 years. New inventions and economic globalization increasingly facilitate people's communication for exchange of ideas and collaboration. This work attempts to describe international research collaboration in educational technology for the past 50 years. This article intends…

  18. Report of the Minnesota Department of Education Survey of School Buildings: 50 Years and Older.

    ERIC Educational Resources Information Center

    Minnesota State Dept. of Education, St. Paul.

    Findings of a study that determined the physical conditions of Minnesota's public school buildings 50 years and older are presented in this report. Data were obtained from a survey that was distributed to 367 school districts that have 614 buildings 50 years and older. Responses were received from 398 buildings in 242 school districts. Findings…

  19. Discovering the 50 Years of Solar System Exploration: Sharing Your Science with the Public

    NASA Astrophysics Data System (ADS)

    Buxner, Sanlyn; Dalton, H.; Shipp, S.; Shupla, C.; Halligan, E.; Boonstra, D.; Wessen, A.; Baerg, G.; Davis, P.; Burdick, A.; Zimmerman Brachman, R.

    2012-10-01

    The Year of the Solar System (YSS) offers ways for scientists to bring NASA’s science discoveries to their audiences! YSS and the continuing salute to the 50-year history of solar system exploration provide an integrated picture of our new understanding of the solar system for educators and the general public. During the last five decades, NASA has launched a variety of robotic spacecraft to study our solar system. Over that time, our understanding of planets has been revolutionized, as has the technology that has made these discoveries possible.Looking forward, the numerous ongoing and future robotic missions are returning new discoveries of our solar system at an unprecedented rate. YSS combines the discoveries of past NASA planetary missions with the most recent findings of the ongoing missions and connects them to related topics based on the big questions of planetary science, including solar system formation, volcanism, ice, and possible life elsewhere. Planetary scientists are encouraged to get involved in YSS in a variety of ways: - Give a talk at a local museum, planetarium, library, or school to share YSS and your research - Partner with a local educational institution to organize a night sky viewing or mission milestone community event - Work with a classroom teacher to explore one of the topics with students - Connect with a planetary science E/PO professional to identify ways to participate, like creating podcasts,vodcasts, or contributing to monthly topics - Share your ideas for events and activities with the planetaryE/PO community to identify partners and pathways for distribution - And more! Promotional and educational materials, updates, a calendar of activities, and a space to share experiences are available at NASA’s Solar System website: http://solarsystem.nasa.gov/yss. This is an exciting time in planetary sciences as we learn about New Worlds and make New Discoveries!

  20. AIDS in adults 50 years of age and over: characteristics, trends and spatial distribution of the risk1

    PubMed Central

    Nogueira, Jordana de Almeida; Silva, Antônia Oliveira; de Sá, Laísa Ribeiro; de Almeida, Sandra Aparecida; Monroe, Aline Aparecida; Villa, Tereza Cristina Scatena

    2014-01-01

    Objective to analyze the sociodemographic characteristics, epidemic trend and spatial distribution of the risk of AIDS in adults 50 years of age and over. Method population-based, ecological study, that used secondary data from the Notifiable Disease Information System (Sinan/AIDS) of Paraíba state from the period January 2000 to December 2010. Results during the study period, 307 cases of AIDS were reported among people 50 years of age or over. There was a predominance of males (205/66, 8%), mixed race, and low education levels. The municipalities with populations above 100 thousand inhabitants reported 58.5% of the cases. There was a progressive increase in cases among women; an increasing trend in the incidence (positive linear correlation); and an advance in the geographical spread of the disease, with expansion to the coastal region and to the interior of the state, reaching municipalities with populations below 30 thousand inhabitants. In some locations the risk of disease was 100 times greater than the relative risk for the state. Conclusion aging, with the feminization and interiorization of the epidemic in adults 50 years of age and over, confirms the need for the induction of affirmative policies targeted toward this age group. PMID:25029044

  1. Watershed-scale Evapotranspiration Changed Little over 50 years of Agricultural Land Abandonment in Southern Michigan

    NASA Astrophysics Data System (ADS)

    Hamilton, S. K.; Hussain, M. Z.; Lowrie, C. J.

    2015-12-01

    The difference between precipitation and stream discharge over annual periods provides an indication of the total water loss to evaporation and evapotranspiration. The response of evaporative water loss to land cover change affects groundwater recharge, stream flow, and lake levels. This study examined the watershed water balance for Augusta Creek, which drains a 95-km2 glacial landscape in southwestern Michigan covered by cropland, grassland, forest, and wetlands. The climate is humid and temperate; between 1964-2014 the water-year precipitation averaged 948 mm and ranged from 695-1386 mm with no temporal trend. Over the study period the percentage of land in agriculture has decreased to about a third of its original extent, with abandoned lands gradually transitioning from old fields to woody vegetation. Comparison of precipitation on the upland watershed to baseflow discharge (USGS data; baseflow estimation by WHAT model) across the 50-year record shows that total evaporative water loss averaged 563 + 103 mm and ranged from 385-897 mm, with no apparent trend over the record. The evaporative water loss accounts for a mean + s.d. of 59 + 6% of precipitation (range, 48-70%). Evaporative water loss was positively related to total precipitation (r2 = 0.74. These results are interpreted using a Budyko plot framework to facilitate comparison with other settings. This water balance approach to infer evaporative water loss compares well with direct measurements in the same watershed since 2009 using eddy covariance (grasslands and crops) and soil moisture monitoring by time-domain reflectometry (grasslands, crops, and forest). Thus the evaporative water loss, which is predominantly by evapotranspiration, has been remarkably similar across a period of changing land cover, leaving a relatively consistent proportion for groundwater recharge and streamflow.

  2. Dynamo Sensitivity in Solar Analogs with 50 Years of Ca II H & K Activity

    NASA Astrophysics Data System (ADS)

    Egeland, Ricky; Soon, Willie H.; Baliunas, Sallie L.; Hall, Jeffrey C.; Pevtsov, Alexei A.; Henry, Gregory W.

    2016-05-01

    The Sun has a steady 11-year cycle in magnetic activity most well-known by the rising and falling in the occurrence of dark sunspots on the solar disk in visible bandpasses. The 11-year cycle is also manifest in the variations of emission in the Ca II H & K line cores, due to non-thermal (i.e. magnetic) heating in the lower chromosphere. The large variation in Ca II H & K emission allows for study of the patterns of long-term variability in other stars thanks to synoptic monitoring with the Mount Wilson Observatory HK photometers (1966-2003) and Lowell Observatory Solar-Stellar Spectrograph (1994-present). Overlapping measurements for a set of 27 nearby solar-analog (spectral types G0-G5) stars were used to calibrate the two instruments and construct time series of magnetic activity up to 50 years in length. Precise properties of fundamental importance to the dynamo are available from Hipparcos, the Geneva-Copenhagen Survey, and CHARA interferometry. Using these long time series and measurements of fundamental properties, we do a comparative study of stellar "twins" to explore the sensitivity of the stellar dynamo to small changes to structure, rotation, and composition. We also compare this sample to the Sun and find hints that the regular periodic variability of the solar cycle may be rare among its nearest neighbors in parameter space.

  3. Fire and Deforestation Dynamics in South America over the Past 50 Years

    NASA Astrophysics Data System (ADS)

    van Marle, M.; Field, R. D.; van der Werf, G.

    2015-12-01

    Fires play an important role in the Earth system and are one of the major sources of greenhouse gases and aerosols. Satellites have been key to understand their spatial and temporal variability in space and time, but the most frequently used satellite datasets start only in 1995. There are still large uncertainties about the frequency and intensity of fires in the pre-satellite time period, especially in regions with active deforestation, which may have changed dramatically in intensity in the past decades influencing fire dynamics. We used two datasets to extend the record of fires and deforestation in the Amazon region back in time: 1) annual forest loss rates starting in 1990 derived from Vegetation Optical Depth (VOD), which is a satellite-based vegetation product that can be used as proxy for forest loss, and 2) horizontal visibility as proxy for fire emissions, reported by weather stations and airports in the Amazon, which started around 1940, and having widespread coverage since 1973. We show that these datasets overlap with fire emission estimates from the Global Fire Emissions Database (GFED) enabling us to estimate fire emissions over the last 50 years. We will discuss how fires have varied over time in this region with globally significant emissions, how droughts have influenced fire activity and deforestation rates, and what the impact is of land-use change caused by fire on emissions in the Amazon region.

  4. Alumina-alumina hip replacement in patients younger than 50 years old.

    PubMed

    Sedel, L; Nizard, R S; Kerboull, L; Witvoet, J

    1994-01-01

    From April 1977 to December 1990, 131 total hip arthroplasties were performed on 113 patients younger than 50 years of age (median, 41 years); 64 were men and 49 women. The majority were active people. Sixty-six hips had no previous operations, and 33 had at least one previous arthroplasty. The femoral component was a cemented collared titanium alloy stem, and alumina socket was cemented for 99 hips and press-fit for 32. The mean follow-up period was five years, with 32 hips followed for more than ten years. Revision arthroplasty was considered as a failure. Survivorship analysis depicted a 97.5% rate of survival at five years, an 89.4% rate at ten years, and an 86.2% at 11 years. Nine revisions were performed: one experienced a femoral head rupture after three years, one had bipolar loosening, one experienced femoral cystic formation, and six were revised for acetabular cup loosening, all from the cemented group. Two revisions occurred on the same patient. No stem revision was necessary before ten years. Only one of these revisions was required in patients aged 40 or younger (64 patients). Alumina-alumina friction is an extremely interesting phenomenon in young patients, and could be related to the low wear debris production. PMID:8118972

  5. 50 years of screening in the Nordic countries: quantifying the effects on cervical cancer incidence

    PubMed Central

    Vaccarella, S; Franceschi, S; Engholm, G; Lönnberg, S; Khan, S; Bray, F

    2014-01-01

    Background: Nordic countries' data offer a unique possibility to evaluate the long-term benefit of cervical cancer screening in a context of increasing risk of human papillomavirus infection. Methods: Ad hoc-refined age-period-cohort models were applied to the last 50-year incidence data from Denmark, Finland, Norway and Sweden to project expected cervical cancer cases in a no-screening scenario. Results: In the absence of screening, projected incidence rates for 2006–2010 in Nordic countries would have been between 3 and 5 times higher than observed rates. Over 60 000 cases or between 41 and 49% of the expected cases of cervical cancer may have been prevented by the introduction of screening in the late 1960 s and early 1970 s. Conclusions: Our study suggests that screening programmes might have prevented a HPV-driven epidemic of cervical cancer in Nordic countries. According to extrapolations from cohort effects, cervical cancer incidence rates in the Nordic countries would have been otherwise comparable to the highest incidence rates currently detected in low-income countries. PMID:24992581

  6. Global nitrogen budgets in cereals: A 50-year assessment for maize, rice, and wheat production systems

    PubMed Central

    Ladha, J. K.; Tirol-Padre, A.; Reddy, C. K.; Cassman, K. G.; Verma, Sudhir; Powlson, D. S.; van Kessel, C.; de B. Richter, Daniel; Chakraborty, Debashis; Pathak, Himanshu

    2016-01-01

    Industrially produced N-fertilizer is essential to the production of cereals that supports current and projected human populations. We constructed a top-down global N budget for maize, rice, and wheat for a 50-year period (1961 to 2010). Cereals harvested a total of 1551 Tg of N, of which 48% was supplied through fertilizer-N and 4% came from net soil depletion. An estimated 48% (737 Tg) of crop N, equal to 29, 38, and 25 kg ha−1 yr−1 for maize, rice, and wheat, respectively, is contributed by sources other than fertilizer- or soil-N. Non-symbiotic N2 fixation appears to be the major source of this N, which is 370 Tg or 24% of total N in the crop, corresponding to 13, 22, and 13 kg ha−1 yr−1 for maize, rice, and wheat, respectively. Manure (217 Tg or 14%) and atmospheric deposition (96 Tg or 6%) are the other sources of N. Crop residues and seed contribute marginally. Our scaling-down approach to estimate the contribution of non-symbiotic N2 fixation is robust because it focuses on global quantities of N in sources and sinks that are easier to estimate, in contrast to estimating N losses per se, because losses are highly soil-, climate-, and crop-specific. PMID:26778035

  7. Molecular Typing of Pathogenic Leptospira Serogroup Icterohaemorrhagiae Strains Circulating in China during the Past 50 Years

    PubMed Central

    Zhang, Cuicai; Yang, Huimian; Li, Xiuwen; Cao, Zhiqiang; Zhou, Haijian; Zeng, Linzi; Xu, Jianmin; Xu, Yinghua; Chang, Yung-Fu; Guo, Xiaokui; Zhu, Yongzhang; Jiang, Xiugao

    2015-01-01

    Background Leptospirosis is one of the most important neglected tropical infectious diseases worldwide. Icterohaemorrhagiae has been throughout recent history, and still is, the predominant serogroup of this pathogen in China. However, very little in detail is known about the serovars or genotypes of this serogroup. Methodology/Principal Findings In this study, 120 epidemic strains from five geographically diverse regions in China collected over a 50 year period (1958~2008), and 8 international reference strains characterized by 16S rRNA sequencing and MLST analysis. 115, 11 and 2 strains were identified as L. interrogans, L. borgpetersenii, and L. kirschneri, respectively. 17 different STs were identified including 69 ST1 strains, 18 ST17, 18 ST128, 9 ST143 and 2 ST209. The remaining 12 strains belonged to 12 different STs. eBURST analysis demonstrated that, among the clonal complexes isolated (CCs), CC1 accounted for 73.3% (88/120) strains representing three STs: ST1, ST128 and ST98. ST1 was the most likely ancestral strain of this CC, followed by singleton CC17 (17/120) and CC143 (11/120). Further analysis of adding 116 serogroup Icterohaemorrhagiae strains in the MLST database and studies previously described using global eBURST analysis and MST dendrogram revealed relatively similar ST clustering patterns with five main CCs and 8 singletons among these 244 strains. CC17 was found to be the most prevalent clone of pathogenic Leptospira circulating worldwide. This is the first time, to our knowledge, that ST1 and ST17 strains were distributed among 4 distinct serovars, indicating a highly complicated relationship between serovars and STs. Conclusions/Significance Our studies demonstrated a high level of genetic diversity in the serogroup Icterohaemorrhagiae strains. Distinct from ST17 or ST37 circulating elsewhere, ST1 included in CC1, has over the past 50 years or so, proven to be the most prevalent ST of pathogenic leptospires isolated in China. Moreover, the

  8. 50 years of the K-BKZ constitutive relation in polymer rheology and processing

    NASA Astrophysics Data System (ADS)

    Mitsoulis, E.

    2014-05-01

    The K-BKZ constitutive model is now 50 years old. The article reviews the connections of the model and its variants with continuum mechanics, presenting an up-to-date recap of research and major findings in the open literature. An historical perspective is given on developments in the last 50 years of the K-BKZ model and its use in rheology and polymer processing.

  9. Biogeochemical control of marine productivity in the Mediterranean Sea during the last 50 years

    NASA Astrophysics Data System (ADS)

    Macias, Diego; Garcia-Gorriz, Elisa; Piroddi, Chiara; Stips, Adolf

    2014-08-01

    The temporal dynamics of biogeochemical variables derived from a coupled 3-D model of the Mediterranean Sea are evaluated for the last 50 years (1960-2010) against independent data on fisheries catch per unit effort (CPUE) for the same time period. Concordant patterns are found in the time series of all of the biological variables (from the model and from fisheries statistics), with low values at the beginning of the series, a later increase, with maximum levels reached at the end of the 1990s, and a posterior stabilization. Spectral analysis of the annual biological time series reveals coincident low-frequency signals in all of them. The first, more energetic signal peaks around the year 2000, while the second, less energetic signal peaks near 1982. Almost identical low-frequency signals are found in the nutrient loads of the rivers and in the integrated nutrient levels in the surface marine ecosystem. Nitrate concentration shows a maximum level in 1998, with a later stabilization to present-day values, coincident with the first low-frequency signal found in the biological series. Phosphate shows maximum concentrations around 1982 and a posterior sharp decline, in concordance with the second low-frequency signal observed in the biological series. That result seems to indicate that the control of marine productivity (plankton to fish) in the Mediterranean is principally mediated through bottom-up processes that could be traced back to the characteristics of riverine discharges. The high sensitivity of CPUE time series to environmental conditions might be another indicator of the overexploitation of this marine ecosystem.

  10. Mortality in relation to smoking: 50 years' observations on male British doctors

    PubMed Central

    Doll, Richard; Peto, Richard; Boreham, Jillian; Sutherland, Isabelle

    2004-01-01

    Objective To compare the hazards of cigarette smoking in men who formed their habits at different periods, and the extent of the reduction in risk when cigarette smoking is stopped at different ages. Design Prospective study that has continued from 1951 to 2001. Setting United Kingdom. Participants 34 439 male British doctors. Information about their smoking habits was obtained in 1951, and periodically thereafter; cause specific mortality was monitored for 50 years. Main outcome measures Overall mortality by smoking habit, considering separately men born in different periods. Results The excess mortality associated with smoking chiefly involved vascular, neoplastic, and respiratory diseases that can be caused by smoking. Men born in 1900-1930 who smoked only cigarettes and continued smoking died on average about 10 years younger than lifelong non-smokers. Cessation at age 60, 50, 40, or 30 years gained, respectively, about 3, 6, 9, or 10 years of life expectancy. The excess mortality associated with cigarette smoking was less for men born in the 19th century and was greatest for men born in the 1920s. The cigarette smoker versus non-smoker probabilities of dying in middle age (35-69) were 42% ν 24% (a twofold death rate ratio) for those born in 1900-1909, but were 43% ν 15% (a threefold death rate ratio) for those born in the 1920s. At older ages, the cigarette smoker versus non-smoker probabilities of surviving from age 70 to 90 were 10% ν 12% at the death rates of the 1950s (that is, among men born around the 1870s) but were 7% ν 33% (again a threefold death rate ratio) at the death rates of the 1990s (that is, among men born around the 1910s). Conclusion A substantial progressive decrease in the mortality rates among non-smokers over the past half century (due to prevention and improved treatment of disease) has been wholly outweighed, among cigarette smokers, by a progressive increase in the smoker ν non-smoker death rate ratio due to earlier and more

  11. [Historical sketch of modern pharmaceutical science and technology (Part 4). Post World War II 50 years].

    PubMed

    Yamakawa, K

    1995-01-01

    A short history of the pharmaceutical science and technology, postwar 50 years is divided into nine sections for the purpose of discussion. 1. Japan's postwar rehabilitation, Japanese pharmaceutical industries and newly developed pharmaceutical sciences and technologies. In 1945, the Japanese pharmaceutical industry was reconstructed. Production of penicillin was carried out with the strong support of the U.S. Occupation Forces. New sciences in pharmacy (biochemistry, biopharmacy, pharmacology, microbiology, physical chemistry, etc.) were introduced in this period. 2. Introduction age of foreign new drugs and technology (1951 to 1960s). Japan gained independence in 1951. Japanese pharmaceutical companies imported many new drugs and new pharmaceutical technologies from the U.S.A. and European countries in this period. Then, these companies were reconstruction rapidly. However, consequently Japanese pharmaceutical companies were formed as an imitation industry. 3. Rapid economic growth period for pharmaceutical companies (1956 to 1970s). In this period, many Japanese pharmaceutical companies grew rapidly at an annual rate of 15-20% over a period of 15 years, especially with regard to the production of active vitamin B1 analog drugs and some OTC (public health drugs). Some major companies made large profits, which were used to construct research facilities. 4. Problems for the harmful effects of medicines and its ethical responsibility. In the 1970s, many public toxic and harmful effects of medicines were caused, especially SMON's disease. In this time, many pharmaceutical companies changed to its security got development of ethical drugs. 5. Self development of new drugs and administration of pharmaceutical rules (1970s). During the 1970s, many pharmaceutical laws (GLP, GCP, GMP, GPMSP etc.) were enacted by the Ministry of Health and Welfare. In 1976, the Japanese Pharmaceutical Affairs Law was revised, which set forth standards regarding the efficacy and safety of

  12. Celebrating 50 Years of Reflective Practice: Versions of Creative Problem Solving

    ERIC Educational Resources Information Center

    Isaksen, Scott G.; Treffinger, Donald J.

    2004-01-01

    The original work of Alex Osborn making the creative process more explicit, and the following 50 years of research and development on creative problem solving, have made an important and wide-spread contribution to those interested in the deliberate development of creative talent. This article provided a summary of the many versions of creative…

  13. The "Global" Formulation of Thermodynamics and the First Law: 50 Years On

    ERIC Educational Resources Information Center

    Gislason, Eric A.; Craig, Norman C.

    2011-01-01

    Nearly 50 years ago, Henry Bent published his groundbreaking article in this "Journal" introducing the "global" formulation of thermodynamics. In the following years, the global formulation was elaborated by Bent and by one of the present authors. The global formulation of the first law focuses on conservation of energy and the recognition that…

  14. The School Health Education Study + 50 Years: Scholars' Reflections on Its Impact and Legacy

    ERIC Educational Resources Information Center

    McDermott, Robert J.; Mayer, Alyssa B.

    2011-01-01

    Background: Launched 50 years ago, the School Health Education Study (SHES) examined the health education offerings in 135 public school systems, in 38 states, and over 1100 elementary schools and 350 secondary schools. In its second year, knowledge surveys were administered to students in grades 6, 9 and 12 at many of these schools. Analysis of…

  15. 1958-2008: 50 Years of Youth Fitness Tests in the United States

    ERIC Educational Resources Information Center

    Morrow, James R., Jr.; Zhu, Weimo; Franks, B. Don; Meredith, Marilu D.; Spain, Christine

    2009-01-01

    The AAHPER Youth Fitness Test, the first U.S. national fitness test, was published 50 years ago. The seminal work of Krause and Hirschland influenced the fitness world and continues to do so today. Important youth fitness test initiatives in the last half century are summarized. Key elements leading to continued interest in youth fitness testing…

  16. Keeping on Keeping on: OCR and Complaints of Racial Discrimination 50 Years after "Brown"

    ERIC Educational Resources Information Center

    Pollock, Mica

    2005-01-01

    This article, written by a former civil rights investigator in the U.S. Department of Education's Office for Civil Rights (OCR), contends that ordinary Americans advocating for equal educational opportunity for students of color might enlist OCR more actively and knowingly to help secure racial equality of opportunity 50 years after "Brown." Now a…

  17. Comprehension of a Colon Cancer Pamphlet among American Adults at Least 50 Years of Age

    ERIC Educational Resources Information Center

    Liu, Chiung-ju

    2010-01-01

    Objective: The purpose of this study was to identify determinants of comprehension of an educational pamphlet on colon cancer, by adults at least 50 years of age living in the United States. Design: Data were analysed from the "2003 National Assessment of Adult Literacy" survey. The survey was designed to assess functional English literacy, which…

  18. Male and Female Photographic Representation in 50 Years of "Music Educators Journal"

    ERIC Educational Resources Information Center

    Kruse, Adam J.; Giebelhausen, Robin; Shouldice, Heather N.; Ramsey, Andrea L.

    2015-01-01

    Considering the potential for stereotypes to shape professional expectations, the four researchers in this study investigated photographic representation of adult men and women in implied positions of authority in 50 years (1962-2011) of issues of "Music Educators Journal" ("MEJ"). Data included every photograph (N = 7,288) of…

  19. Optical Sciences Center/College of Optical Sciences: 50 years of excellence

    NASA Astrophysics Data System (ADS)

    Wyant, James C.

    2014-09-01

    Aden B. Meinel established the University of Arizona Optical Sciences Center, now known as the College of Optical Sciences, in 1964 to fulfill a national need for more highly trained engineers and physicists in the optical sciences. Throughout its 50-year history, OSC has grown and evolved in response to industrial demand. It now includes a worldclass faculty and an international student body, and its academic programs offer more than 100 graduate and undergraduate courses, an ABET-accredited undergraduate optical sciences and engineering degree program, and outstanding M.S. and Ph.D. graduate programs with extensive distance learning options. Its graduates are in great demand and are employed by national and international governments, businesses and universities. This paper will describe the formation of OSC and its 50 years of excellence.

  20. Effects of 50-years unmanaged water resource in Southern Tuscany coastal plains (Italy)

    NASA Astrophysics Data System (ADS)

    Rossetto, R.; Debolini, M.; Galli, M. A.; Bonari, E.

    2012-04-01

    original 4 Mm3. Having a reduced access to water resources, most of the farms during the 90's moved to more efficient water uses (drip irrigation) to save crops from leaf burns or switched to less-water-demanding, but less profitable crops. As a consequence, less competitive areas in the production-distribution chain suffered aquifer' salinisation and were progressively abandoned. As far as drinking water supply, the area is facing water scarcity during the summer period; desalination plants are planned. In one of the plain the water utility pumps out salinised groundwater that is then desalinized with an obvious increase in energy consumption. Although water management needs have grown during the last 50 years and several studies outlined the importance of planning this resource, conflicts among stakeholders and political issues make such problems of difficult solution. Today large dam building seems to be quite unreliable both because of the construction time and the financial issues related. At the same time feasible projects, driven also by innovative and more profitable agricultural development, call for wastewater reuse and artificial aquifer recharge starting at least from pilot tests in priority areas.

  1. Space optics contributions by the College of Optical Sciences over the past 50 years

    NASA Astrophysics Data System (ADS)

    Breckinridge, James B.; Smith, Peter

    2014-10-01

    We present a review of the contributions by students, staff, faculty and alumni to the Nation's space program over the past 50 years. The balloon polariscope led the way to future space optics missions. The missions Pioneer Venus (large probe solar flux radiometer), Pioneer 10/11 (imaging photopolarimeter) to Jupiter and Saturn, Hubble Space Telescope (HST), and next generation large aperture space telescopes are discussed.

  2. Determination of snow avalanche return periods using a tree-ring based reconstruction in the French Alps: cross validation with the predictions of a statistical-dynamical model

    NASA Astrophysics Data System (ADS)

    Schläppy, Romain; Eckert, Nicolas; Jomelli, Vincent; Grancher, Delphine; Brunstein, Daniel; Stoffel, Markus; Naaim, Mohamed

    2013-04-01

    Documenting past avalanche activity represents an indispensable step in avalanche hazard assessment. Nevertheless, (i) archival records of past avalanche events do not normally yield data with satisfying spatial and temporal resolution and (ii) precision concerning runout distance is generally poorly defined. In addition, historic documentation is most often (iii) biased toward events that caused damage to structure or loss of life on the one hand and (iv) undersampled in unpopulated areas on the other hand. On forested paths dendrogeomorphology has been demonstrated to represent a powerful tool to reconstruct past activity of avalanches with annual resolution and for periods covering the past decades to centuries. This method is based on the fact that living trees may be affected by snow avalanches during their flow and deposition phases. Affected trees will react upon these disturbances with a certain growth response. An analysis of the responses recorded in tree rings coupled with an evaluation of the position of reacting trees within the path allows the dendrogeomorphic expert to identify past snow avalanche events and deduced their minimum runout distance. The objective of the work presented here is firstly to dendrochronogically -reconstruct snow avalanche activity in the Château Jouan path located near Montgenèvre in the French Alps. Minimal runout distances are then determined for each reconstructed event by considering the point of further reach along the topographic profile. Related empirical return intervals are evaluated, combining the extent of each event with the average local frequency of the dendrological record. In a second step, the runout distance distribution derived from dendrochronological reconstruction is compared to the one derived from historical archives and to high return period avalanches predicted by an up-to-date locally calibrated statistical-numerical model. It appears that dendrochronological reconstructions correspond mostly to

  3. The distributions of Chinese yak breeds in response to climate change over the past 50 years.

    PubMed

    Wu, Jianguo

    2016-07-01

    The effects of prior climate change on yak breed distributions are uncertain. Here, we measured changes in the distributions of 12 yak breeds over the past 50 years in China and examined whether the changes could be attributed to climate change. Long-term records of yak breed distribution, grey relational analysis, fuzzy sets classification techniques and attribution methods were used. Over the past 50 years, the distributions of several yak breeds have changed in multiple directions, mainly shifting northward or westward, and most of these changes are related to the thermal index. Driven by climate change over the past years, the suitable range and the distribution centers of certain yak breeds have changed with fluctuation and have mainly shifted northward, eastward or southward. The consistency of observed versus predicted changes in distribution boundaries or distribution centers is higher for certain yak breeds. Changes in the eastern distribution boundary of two yak breeds over the past 50 years can be attributed to climate change. PMID:26470629

  4. Instruction and Curriculum in Veterinary Medical Education: A 50-Year Perspective.

    PubMed

    Fletcher, Oscar J; Hooper, Billy E; Schoenfeld-Tacher, Regina

    2015-01-01

    Our knowledge of veterinary medicine has expanded greatly over the past 50 years. To keep pace with these changes and produce competent professionals ready to meet evolving societal needs, instruction within veterinary medical curricula has undergone a parallel evolution. The curriculum of 1966 has given way, shifting away from lecture-laboratory model with few visual aids to a program of active learning, significant increases in case- or problem-based activities, and applications of technology, including computers, that were unimaginable 50 years ago. Curricula in veterinary colleges no longer keep all students in lockstep or limit clinical experiences to the fourth year, and instead have moved towards core electives with clinical activities provided from year 1. Provided here are examples of change within veterinary medical education that, in the view of the authors, had positive impacts on the evolution of instruction and curriculum. These improvements in both how and what we teach are now being made at a more rapid pace than at any other time in history and are based on the work of many faculty and administrators over the past 50 years. PMID:26673214

  5. [The historical aspect: the first 10 years of the Danish Medicines Agency--and the 50 years that came before].

    PubMed

    Overø, Jens

    2008-01-01

    In 1997, the office for administration regarding medicines and pharmacies was separated from the Danish Board of Health and organised as the Danish Medicines Agency (Laegemiddelstyrelsen). This Agency celebrated its 10 years anniversary by publishing a book, "Staten og laegemidlerne" (The state and the medicines), describing various aspects of the official control of medicines. The book chapters focus mainly on the latest 25-50 years, because the earlier periods from the 16th century and onwards have been thoroughly described previously, whereas more recent developments are more sparsely discussed in the literature. The present article emphasises the importance of keeping knowledge of the historical development alive. Many aspects of present day regulation only make sense with knowledge of what came before. PMID:18548943

  6. Geologic Exploration of the Planets: A Personal Retrospective of the First 50 years

    NASA Astrophysics Data System (ADS)

    Carr, M. H.

    2013-12-01

    The modern era of exploration of planets and satellites beyond the Earth-Moon system began on 14 December 1962 when the Mariner 2 spacecraft flew by Venus. Since that time roughly 80 spacecraft have successfully visited other planets and their satellites. In 1962 we knew nothing of the geology of the non-terrestrial planets and satellites; they were just variously shaded discs and dots. Most of us entering the new field of planetary geology at the time did so in anticipation of the Apollo lunar landings. I was hired by Gene Shoemaker to work on lunar issues and to participate in the lunar geologic mapping program that he had initiated at the USGS. Lunar studies led naturally to planetary studies but none of us could have anticipated the geologic variety that exists within the Solar System as exemplified by the coronae of Venus, the canyons of Mars, the volcanoes of Io, the ice tectonics of Europa and Ganymede, the geysers of Enceladus and the methane-carved valleys of Titan. Although Mars appeared lunar-like in the first close-up images from the Mariner 4 (1965) and Mariners 6 and 7 (1969) fly-bys, the Mariner 9 (1971) orbiter soon revealed Mars' geologic variety. Planning imaging for Mariner 9 was challenging; aids were primitive and we essentially had a blank sheet to fill. By 1971, the Viking Project with its main objective to land on Mars and search for signs of life was well underway. In 1969 I was appointed leader of the Viking Orbiter imaging team. The main function of the cameras was to ensure that the landing sites were safe before landing. In 1976 when we acquired the first close-up images of the pre-chosen landing sites they were greeted with elation and horror, elation because of their quality, horror because of the roughness of the terrain that had seemed so smooth in the Mariner 9 images. There followed an intense period of searching for safer sites and ultimately the two landers did land safely. The search for life then followed with hopes soaring as

  7. Formation of the 50-Year Element 94 from Deuteron Bombardment of U{sup 238}

    DOE R&D Accomplishments Database

    Kennedy, J. W.; Perlman, M. L.; Segre, E.; Wahl, A. C.

    1942-06-01

    It has been shown by bombardment with deuterons of a sample of U{sup 238}, greatly depleted in U{sup 235} and U{sup 234}, that the 50-year 94 activity and 2.0 day 93 activity are formed in approximately the same yield as with the natural mixture of uranium isotopes. The activities are thus shown to arise from the U{sup 238} nucleus, and from considerations of the energy of the compound nucleus (U{sup 238} + d).

  8. Rapid eye movement sleep behavior disorder in adults younger than 50 years of age.

    PubMed

    Ju, Yo-El S

    2013-08-01

    Rapid eye movement (REM) sleep behavior disorder (RBD) occurring prior to age 50 is termed early-onset RBD. Early-onset RBD comprises a substantial minority of cases, and demonstrates the differences in demographics, comorbidities, and clinical considerations from previously described typical RBD with onset >50years. The world literature on RBD is reviewed with specific focus on features that distinguish early-onset RBD, including more gender parity, increased proportion of idiopathic cases, increased proportion of cases associated with narcolepsy, parasomnia overlap disorder, antidepressants, and possibly autoimmune disorders, and clinical presentation. PMID:23347910

  9. 50 years of helium liquefaction at the MIT Cryogenic Engineering Laboratory

    NASA Astrophysics Data System (ADS)

    Smith, Joseph L.

    2002-05-01

    The evolution of the helium liquefaction facility of the MIT Cryogenic Engineering Laboratory and the history of its operation over the last 50 years are described. Professor Samuel C. Collins created the liquid-helium facility based on his earlier developments. The chronology of the laboratory helium liquefiers is given with a brief description of each one. The current facility based on the Model 2000 liquefier is described and operating experience is given. The reasons for the very high availability of the liquefaction system are developed.

  10. Heel pain due to psoriatic arthritis in a 50 year old recreational male athlete: case report

    PubMed Central

    Yedon, Dominique Forand; Howitt, Scott

    2011-01-01

    Heel pain is a common presentation in a sports injury practice, with a list of common differentials including achilles tendinopathy and retrocalcaneal bursitis. However, seronegative arthritis can also cause enthesopathies that produce heel pain and should be considered in a differential diagnosis list. In this case, a 50 year old recreationally active male presented with non-traumatic insidious heel pain and without history of any skin conditions or any other symptoms of seronegative spondyloarthritis. Clinical suspicion led to laboratory testing and radiographs/bone scan which yielded the diagnosis of psoriatic arthritis. PMID:22131565

  11. A Perspective on the Intended Science Curriculum in Iceland and Its "Transformation" over a Period of 50 Years

    ERIC Educational Resources Information Center

    Thorolfsson, Meyvant; Finnbogason, Gunnar E.; Macdonald, Allyson

    2012-01-01

    In recent decades, a consensus has emerged among educators and scientists that all compulsory school students need good science education. The debate about its purpose and nature as a school subject in an emerging information society has not been as conclusive. To further understand this, it helps to examine how the science curriculum has…

  12. [Progress in and outcomes of neonatal surgery over the past 50 years].

    PubMed

    Taguchi, Tomoaki; Nagata, Kouji; Kinoshita, Yoshiaki; Esumi, Genshiro

    2014-11-01

    The Japanese Society of Pediatric Surgeons has performed a nationwide survey of neonatal surgery every 5 years during the 50 years since its foundation. The number of neonatal surgical cases has increased 5-fold during those 50 years, while the mortality rate has decreased from 60% to 15% for the main life-threatening diseases (such as esophageal atresia, diaphragmatic hernia, omphalocele, and gastroschisis). Currently, most neonatal patients who undergo surgery for severe cardiac or chromosomal anomalies survive. Therefore, pediatric surgeons are aware of the need for cosmetic considerations. Endoscopic surgical procedures and incisions using natural skin creases have been developed to achieve good cosmetic results and improve patients' quality of life. On the other hand, severe life-threatening neonatal surgical cases are still seen, such as patients with diaphragmatic hernia accompanied by severe pulmonary hypoplasia, huge sacrococcygeal teratomas, and neonatal intestinal perforation. Fetal intervention or early delivery should be considered to improve survival. Appropriate initial treatment strategies for intestinal perforation in very low birth-weight infants are needed. PMID:25702509

  13. Dietary patterns and risk of hip fractures in postmenopausal women and men over 50 years

    PubMed Central

    Fung, Teresa T.; Feskanich, Diane

    2016-01-01

    Purpose We examined the association between predominant dietary patterns and risk of hip fractures in postmenopausal women and men over 50 years. Methods We used data from 74,540 women in the Nurses’ Health Study followed between 1980 and 2010, and 35,451 men from the Health Professionals Follow-up Study followed between 1986 and 2012 for this analysis. Health and lifestyle information was assessed every two years. Diet was assessed approximately every four years with a food frequency questionnaire. Two major dietary patterns were previously derived using principal component analysis. The Prudent pattern is characterized by higher intakes of fruits, vegetables, whole grains, and poultry, and the Western pattern is characterized by higher intakes of red and processed meats, sweets, and refined grains. We computed relative risks (RR) for hip fracture by dietary pattern scores using Cox proportional hazards models, adjusting for potential confounders. Results During follow-up, there were 1891 hip fractures in women and 596 in men. No association was observed between the Prudent or Western pattern and risk of hip fractures in either men or women. We also did not find an association among lean (BMI<25) or overweight (BMI >=25) individuals or among those with higher or lower levels of physical activity. Conclusion Neither the Prudent nor the Western dietary pattern was associated with risk of hip fractures in postmenopausal women or men over 50 years of age. PMID:25731807

  14. Total hip arthroplasty in patients 50 years or less: do we improve activity profiles?

    PubMed

    Kuhn, Margaret; Harris-Hayes, Marcie; Steger-May, Karen; Pashos, Gail; Clohisy, John C

    2013-05-01

    The primary objective of this study was to use step activity monitoring to quantify activity changes after total hip arthroplasty in patients 50 years or less. Secondly, we investigated whether step activity measurements correlated with the Harris hip and UCLA scores. We prospectively analyzed 37 patients (age ≤ 50) treated with primary THA. Patient activity was recorded with a step activity monitor. Harris hip and UCLA scores were analyzed. Total daily stride counts increased by an average of 30.0%. Increases were noted in the percent of daily time spent at high, moderate and low activity. Increases in daily time spent at high activity moderately correlated with the UCLA activity score but did not correlate with the HHS. Both the UCLA score and the HHS did not correlate with mean daily strides. Following THA, patients ≤ 50 years of age increase their activity by taking more daily strides and improve their activity profile by spending more time at higher activity. Improvements in step activity moderately correlate with improvements in UCLA scores. PMID:23499406

  15. Long Return Periods for Earthquakes in San Gorgonio Pass and Implications for Large Ruptures of the San Andreas Fault in Southern California

    NASA Astrophysics Data System (ADS)

    Yule, J.; McBurnett, P.; Ramzan, S.

    2011-12-01

    The largest discontinuity in the surface trace of the San Andreas fault occurs in southern California at San Gorgonio Pass. Here, San Andreas motion moves through a 20 km-wide compressive stepover on the dextral-oblique-slip thrust system known as the San Gorgonio Pass fault zone. This thrust-dominated system is thought to rupture during very large San Andreas events that also involve strike-slip fault segments north and south of the Pass region. A wealth of paleoseismic data document that the San Andreas fault segments on either side of the Pass, in the San Bernardino/Mojave Desert and Coachella Valley regions, rupture on average every ~100 yrs and ~200 yrs, respectively. In contrast, we report here a notably longer return period for ruptures of the San Gorgonio Pass fault zone. For example, features exposed in trenches at the Cabezon site reveal that the most recent earthquake occurred 600-700 yrs ago (this and other ages reported here are constrained by C-14 calibrated ages from charcoal). The rupture at Cabezon broke a 10 m-wide zone of east-west striking thrusts and produced a >2 m-high scarp. Slip during this event is estimated to be >4.5 m. Evidence for a penultimate event was not uncovered but presumably lies beneath ~1000 yr-old strata at the base of the trenches. In Millard Canyon, 5 km to the west of Cabezon, the San Gorgonio Pass fault zone splits into two splays. The northern splay is expressed by 2.5 ± 0.7 m and 5.0 ± 0.7 m scarps in alluvial terraces constrained to be ~1300 and ~2500 yrs old, respectively. The scarp on the younger, low terrace postdates terrace abandonment ~1300 yrs ago and probably correlates with the 600-700 yr-old event at Cabezon, though we cannot rule out that a different event produced the northern Millard scarp. Trenches excavated in the low terrace reveal growth folding and secondary faulting and clear evidence for a penultimate event ~1350-1450 yrs ago, during alluvial deposition prior to the abandonment of the low terrace

  16. The Last 50 Years: Mismeasurement and Mismanagement Are Impeding Scientific Research.

    PubMed

    Lawrence, Peter A

    2016-01-01

    In the last 50 years, there have been many changes to the substance, conduct, and style of research. Many of these changes have proved disastrous to the life of scientists and to science itself. As a consequence, the near-romantic spirit of adventure and exploration that inspired young scientists of my own and earlier generations has become tarnished. Now, many of us feel beleaguered by bureaucrats and by politicians: they affect our lives profoundly, apparently without an understanding of the way discoveries are made or of the nature of science itself. The core purposes of universities, teaching and research, are being eroded by excessive administration. The number and locations of our publications are counted up like beans and the outcomes are used to rank us, one against another; a process of evaluation that has recast the purposes of publication. Applying for grants takes far too much time from a young scientist's life. PMID:26970645

  17. Cardiomyopathy Induced by Pulmonary Sequestration in a 50-Year-Old Man

    PubMed Central

    Chatelain, Shaun; Comp, Robert A.; Grace, R. Randal

    2015-01-01

    A 50-year-old black man presented at the emergency department with midsternal, nonradiating chest pressure and chronic dyspnea on exertion. Four years before the current admission, he had been diagnosed with nonischemic cardiomyopathy at another facility. After our complete evaluation, we suspected that his symptoms arose from left-to-left shunting in association with pulmonary sequestration, a congenital malformation. Our preliminary diagnosis of secondary dilated cardiomyopathy was confirmed by normalization of the patient's ventricular size and function after lobectomy. To our knowledge, this patient is the oldest on record to present with cardiomyopathy consequent to pulmonary sequestration. His case is highly unusual because of his age and the rapid resolution of his symptoms after lobectomy. We believe that pulmonary sequestration should be included in the differential diagnosis of dilated cardiomyopathy. PMID:25873803

  18. [The 50-year-old women or older: preventive actions to the HIV infection].

    PubMed

    Rodrigues, Daniela Angelo de Lima; Praça, Neide de Souza

    2010-06-01

    The present study is a qualitative research which aimed to verify the adoption of preventive measures on the transmission of HIV in 50-year-old women or older, who lived in poor communities and were assisted by the Family Health Program in São Paulo, Brazil. Medical Anthropology has been adopted as a theoretical reference, as well as the Discourse of the Collective Individual for data analysis. Thirteen women were interviewed and three discourses were presented: prevention appreciation, invisibility of HIV/AIDS and the rejection of the use of condom. The analysis showed that the group did not realize the risk of contamination through sexual intercourse due to their trust in the partner's loyalty. The casual use of condoms was taken into consideration just out of curiosity. The preventive actions adopted need more scientific support. The results point out the necessity of planning and implementing interventions which are culturally based and directed to the studied segment. PMID:21500513

  19. A review of 50 years of aerodynamic research with NACA/NASA

    NASA Technical Reports Server (NTRS)

    Spearman, M. Leroy

    1994-01-01

    Continuous improvements in flight systems have occurred over the past 50 years due, in part, to continuous improvements in aerodynamic research techniques and capabilities. This paper traces that research from the first-hand perspective of the author who, beginning in 1944, has taken part in the NACA/NASA aerodynamic research effort through studies in low-speed wind tunnels, high-speed subsonic tunnels, transonic tunnels, supersonic tunnels, and hypersonic tunnels. New problems were found as systems advanced from low-speed propeller-driven designs to more sophisticated high-speed jet- and rocket-propelled designs. The paper reviews some of these problems and reflects on some of the solutions that have been developed in the course of various aerodynamic research programs in the past. Some of the factors, both technical and nontechnical, that have influenced the aerodynamic design, research, and development of various flight systems will be mentioned.

  20. Association of American Veterinary Medical Colleges (AAVMC): 50 Years of History and Service.

    PubMed

    Maccabe, Andrew T; Crawford, Lester; Heider, Lawrence E; Hooper, Billy; Mann, Curt J; Pappaioanou, Marguerite

    2015-01-01

    The mission of the Association of American Veterinary Medical Colleges (AAVMC) is to advance the quality of academic veterinary medicine. Founded in 1966 by the 18 US colleges of veterinary medicine and 3 Canadian colleges of veterinary medicine then in existence, the AAVMC is celebrating 50 years of public service. Initially, the AAVMC comprised the Council of Deans, the Council of Educators, and the Council of Chairs. In 1984, the tri-cameral structure was abandoned and a new governing structure with a board of directors was created. In 1997, the AAVMC was incorporated in Washington, DC and a common application service was created. Matters such as workforce issues and the cost of veterinary medical education have persisted for decades. The AAVMC is a champion of diversity in the veterinary profession and a strong advocate for One Health. The AAVMC has adopted a global perspective as more international colleges of veterinary medicine have earned COE accreditation and become members. PMID:26673207

  1. The Last 50 Years: Mismeasurement and Mismanagement Are Impeding Scientific Research

    PubMed Central

    Lawrence, Peter A.

    2016-01-01

    In the last 50 years, there have been many changes to the substance, conduct, and style of research. Many of these changes have proved disastrous to the life of scientists and to science itself. As a consequence, the near-romantic spirit of adventure and exploration that inspired young scientists of my own and earlier generations has become tarnished. Now, many of us feel beleaguered by bureaucrats and by politicians: they affect our lives profoundly, apparently without an understanding of the way discoveries are made or of the nature of science itself. The core purposes of universities, teaching and research, are being eroded by excessive administration. The number and locations of our publications are counted up like beans and the outcomes are used to rank us, one against another; a process of evaluation that has recast the purposes of publication. Applying for grants takes far too much time from a young scientist's life. PMID:26970645

  2. The psychological impact of a catastrophic earthquake: a retrospective study 50 years after the event.

    PubMed

    Lazaratou, Helen; Paparrigopoulos, Thomas; Galanos, Gerassimos; Psarros, Constantinos; Dikeos, Dimitris; Soldatos, Constantin

    2008-04-01

    Aim of the present study was to retrospectively assess the impact of a catastrophic earthquake in a sample of 121 survivors, 50 years after the event. Mean age +/- SD of the responders was 72.2 +/- 6.1 years. The majority of the victims (78%) acknowledged a strong overall impact of the earthquake on their lives, and almost all of them had intense recollection of the event at its anniversary. The most frequent symptom during the 6 months after the earthquake was persistent remembering or "reliving" of the event; women had considerably more often recurrent dreams of the earthquake and distress than did men. Women and young adults at the time of the earthquake appear to be the most vulnerable groups regarding the psychological effects of the event. PMID:18414131

  3. The Swedish monitoring of surface waters: 50 years of adaptive monitoring.

    PubMed

    Fölster, Jens; Johnson, Richard K; Futter, Martyn N; Wilander, Anders

    2014-01-01

    For more than 50 years, scientific insights from surface water monitoring have supported Swedish evidence-based environmental management. Efforts to understand and control eutrophication in the 1960s led to construction of wastewater treatment plants with phosphorus retention, while acid rain research in the 1970s contributed to international legislation curbing emissions. By the 1990s, long-time series were being used to infer climate effects on surface water chemistry and biology. Monitoring data play a key role in implementing the EU Water Framework Directive and other legislation and have been used to show beneficial effects of agricultural management on Baltic Sea eutrophication. The Swedish experience demonstrates that well-designed and financially supported surface water monitoring can be used to understand and manage a range of stressors and societal concerns. Using scientifically sound adaptive monitoring principles to balance continuity and change has ensured long-time series and the capability to address new questions over time. PMID:25403966

  4. Microstructure of 50 year old SCK CEN BR1 research reactor fuel

    SciTech Connect

    Leenaers, A.; Berghe, S. van den

    2008-07-15

    The BR1 research reactor at SCK CEN, Mol (Belgium) has a graphite core matrix loaded with fuel rods consisting of a natural uranium slug in an aluminum cladding. Fabrication reports show the application of a so-called AlSi bonding layer and an U(Al,Si){sub 3} anti-diffusion layer on the natural uranium fuel slug to limit the interaction between the uranium fuel and aluminum cladding. The BR1 reactor is in operation since 1956 and still contains its original fuel rods. After more than 50 years irradiation at low temperature, the integrity of some of the fuel rods is investigated. The microstructure of the fuel, bonding and anti-diffusion layer and cladding is analysed using optical microscopy (OM), scanning electron microscopy (SEM) and electron microprobe analysis (EPMA). (author)

  5. A reflection on the first 50 years of Water Resources Research

    NASA Astrophysics Data System (ADS)

    Rajaram, Harihar; Bahr, Jean M.; Blöschl, Günter; Cai, Ximing; Scott Mackay, D.; Michalak, Anna M.; Montanari, Alberto; Sanchez-Villa, Xavier; Sander, Graham

    2015-10-01

    The year 2015 marks the 50th anniversary of Water Resources Research (WRR), which was founded in 1965. More than 15,000 papers have been published in WRR since its inception, and these papers have been cited more than 430,000 times. The history of hydrology and the water sciences are also reflected in WRR, which has served as a premier publication outlet and instigator of scientific growth over the last 50 years. The legacy of WRR provides a strong scientific foundation for the hydrology community to rise to the challenges of sustainable water resources management in a future where dramatic environmental change and increasing human population are expected to stress the world's water resources from local to global scales.

  6. Stabilization Wedges and the Management of Global Carbon for the next 50 years

    ScienceCinema

    Socolow, Robert [Princeton University, Princeton, New Jersey, United States

    2009-09-01

    More than 40 years after receiving a Ph.D. in physics, I am still working on problems where conservation laws matter. In particular, for the problems I work on now, the conservation of the carbon atom matters. I will tell the saga of an annual flow of 8 billion tons of carbon associated with the global extraction of fossil fuels from underground. Until recently, it was taken for granted that virtually all of this carbon will move within weeks through engines of various kinds and then into the atmosphere. For compelling environmental reasons, I and many others are challenging this complacent view, asking whether the carbon might wisely be directed elsewhere. To frame this and similar discussions, Steve Pacala and I introduced the 'stabilization wedge' in 2004 as a useful unit for discussing climate stabilization. Updating the definition, a wedge is the reduction of CO2 emissions by one billion tons of carbon per year in 2057, achieved by any strategy generated as a result of deliberate attention to global carbon. Each strategy uses already commercialized technology, generally at much larger scale than today. Implementing seven wedges should enable the world to achieve the interim goal of emitting no more CO2 globally in 2057 than today. This would place humanity, approximately, on a path to stabilizing CO2 at less than double the pre-industrial concentration, and it would put those at the helm in the following 50 years in a position to drive CO2 emissions to a net of zero in the following 50 years. Arguably, the tasks of the two half-centuries are comparably difficult.

  7. Benthic foraminiferal assemblages in Osaka Bay, southwestern Japan: Faunal changes over the last 50 years

    USGS Publications Warehouse

    Tsujimoto, Akira; Nomura, Ritsuo; Yasuhara, Moriaki; Yoshikawa, Shusaku

    2006-01-01

    Live benthic foraminiferal assemblages from surface sediment in Osaka Bay collected in 1999 were analyzed to characterize the distribution of the modern foraminiferal assemblages. Foraminiferal assemblages were compared with those of previous studies to document environmental changes in Osaka Bay over the past 50 years. Sixty-one species of foraminifera belonging to 37 genera were recognized from the 1999 surface sediment samples. An agglutinated assemblage containing Trochammina hadai and Eggerella advena is dominant in the inner part of the bay and is related to eutrophication. The foraminiferal assemblage in areas deeper than about 20 m is composed of Eggerella advena, Ammonia beccarii forma A, and Pseudorotalia gaimardii. This assemblage may be influenced by the large clockwise Okinose Circulation Current which extends throughout the western bay. Foraminiferal assemblages in Osaka Bay have changed dramatically during the last 50 years. The Trochammina hadai-Eggerella advena assemblage became established in the inner part of the bay, reflecting eutrophication that progressed from the 1960s through the 1970s. This assemblage became dominant in 1983, and typically dominated the inner part of the bay. From 1983 to 1999, however, the abundance of taxa belonging to this assemblage decreased greatly following implementation of 1973 Osaka City bylaws that restricted wastewater discharge. Changes in benthic assemblages such as the decrease of Ammonia beccarii forma A and increase of Eggerella advena have occurred in response to decreased incidence of red tides, and floral change in the species that cause these tides. The results of this study demonstrate that the abundance and distribution of benthic foraminifers in Osaka Bay are intimately related to environmental changes related to the urbanization of coastal areas. ?? by the Palaeontological Society of Japan.

  8. Noninvasive assessment of cardiomyopathy in normotensive diabetic patients between 20 and 50 years old

    SciTech Connect

    Bouchard, A.; Sanz, N.; Botvinick, E.H.; Phillips, N.; Heilbron, D.; Byrd, B.F. 3d.; Karam, J.H.; Schiller, N.B. )

    1989-08-01

    To further the understanding of diabetic heart disease, we tested the hypothesis that an asymptomatic group of normotensive diabetic patients between 20 and 50 years old had a restrictive cardiomyopathy independent of clinically significant coronary artery disease. Quantitative two-dimensional echocardiography and stress myocardial perfusion scintigraphy were performed to detect and characterize the cardiac abnormalities in this study group comprising 88 patients with rigorously classified diabetes and 65 volunteer control subjects. Diabetic patients were shown to have a mildly reduced left ventricular end-diastolic volume index: 50.1 +/- 8.2 and 52.1 +/- 14.7 mL/m2 for patients with type I and type II diabetes, respectively, versus 58.9 +/- 11.7 mL/m2 for control subjects. The left ventricular diastolic filling was also impaired in diabetic patients as reflected by a lower atrial emptying index: 0.73 +/- 0.24 and 0.76 +/- 0.3 for type I and type II diabetics, respectively, compared with 1.14 +/- 0.24 for control subjects. Exercise tolerance was normal in subjects with type I diabetes and slightly reduced in subjects with type II diabetes. Only one patient developed regional ischemia on thallium exercise testing. Using a comprehensive, noninvasive approach, we have shown that asymptomatic normotensive patients with type I or type II diabetes who were between 20 and 50 years old had a restrictive cardiomyopathy characterized by mildly reduced left ventricular end-diastolic volume and altered left ventricular compliance independent of critical coronary artery disease.

  9. Stabilization Wedges and the Management of Global Carbon for the next 50 years

    SciTech Connect

    Socolow, Robert

    2007-04-18

    More than 40 years after receiving a Ph.D. in physics, I am still working on problems where conservation laws matter. In particular, for the problems I work on now, the conservation of the carbon atom matters. I will tell the saga of an annual flow of 8 billion tons of carbon associated with the global extraction of fossil fuels from underground. Until recently, it was taken for granted that virtually all of this carbon will move within weeks through engines of various kinds and then into the atmosphere. For compelling environmental reasons, I and many others are challenging this complacent view, asking whether the carbon might wisely be directed elsewhere. To frame this and similar discussions, Steve Pacala and I introduced the 'stabilization wedge' in 2004 as a useful unit for discussing climate stabilization. Updating the definition, a wedge is the reduction of CO2 emissions by one billion tons of carbon per year in 2057, achieved by any strategy generated as a result of deliberate attention to global carbon. Each strategy uses already commercialized technology, generally at much larger scale than today. Implementing seven wedges should enable the world to achieve the interim goal of emitting no more CO2 globally in 2057 than today. This would place humanity, approximately, on a path to stabilizing CO2 at less than double the pre-industrial concentration, and it would put those at the helm in the following 50 years in a position to drive CO2 emissions to a net of zero in the following 50 years. Arguably, the tasks of the two half-centuries are comparably difficult.

  10. Stabilization Wedges and the Management of Global Carbon for the Next 50 Years

    SciTech Connect

    Socolow, Robert

    2007-04-18

    More than 40 years after receiving a Ph.D. in physics, I am still working on problems where conservation laws matter. In particular, for the problems I work on now, the conservation of the carbon atom matters. I will tell the saga of an annual flow of 8 billion tons of carbon associated with the global extraction of fossil fuels from underground. Until recently, it was taken for granted that virtually all of this carbon will move within weeks through engines of various kinds and then into the atmosphere. For compelling environmental reasons, I and many others are challenging this complacent view, asking whether the carbon might wisely be directed elsewhere. To frame this and similar discussions, Steve Pacala and I introduced the 'stabilization wedge' in 2004 as a useful unit for discussing climate stabilization. Updating the definition, a wedge is the reduction of CO2 emissions by one billion tons of carbon per year in 2057, achieved by any strategy generated as a result of deliberate attention to global carbon. Each strategy uses already commercialized technology, generally at much larger scale than today. Implementing seven wedges should enable the world to achieve the interim goal of emitting no more CO2 globally in 2057 than today. This would place humanity, approximately, on a path to stabilizing CO2 at less than double the pre-industrial concentration, and it would put those at the helm in the following 50 years in a position to drive CO2 emissions to a net of zero in the following 50 years. Arguably, the tasks of the two half-centuries are comparably difficult.

  11. Exploring the dynamics of agricultural climatic resource utilization of spring maize over the past 50 years in Northeast China

    NASA Astrophysics Data System (ADS)

    Zhao, Junfang; Guo, Jianping; Mu, Jia; Xu, Yanhong

    Exploring the dynamics of the utilization of agricultural climatic resources (i.e., environmental factors that affect crop productivity such as light, temperature, and water) can provide a theoretical basis for modifying agricultural practices and distributions of agricultural production in the future. Northeast China is one of the major agricultural production areas in China and also an obvious region of climatic warming. We were motivated to analyze the utilization dynamics of agricultural climatic resource during spring maize cultivation from 1961 to 2010 in Northeast China. To understand these dynamics, we used the daily data from 101 meteorological stations in Northeast China between 1961 and 2010. The demands on agricultural climatic resources in Northeast China imposed by the cultivation of spring maize were combined and agricultural climatic suitability theory was applied. The growth period of spring maize was further detailedly divided into four stages: germination to emergence, emergence to jointing, jointing to tasseling, and tasseling to maturity. The average resource utilization index was established to evaluate the effects. Over the past five decades, Northeast China experienced increases in daily average temperature of 0.246 °C every decade during the growing season (May-September). At the same time, strong fluctuating decreases were observed in average total precipitation of 8.936 mm every decade and an average sunshine hour of 0.122 h every decade. Significant temporal and spatial changes occurred in K from 1961 to 2010. The K showed decreasing trends in Liaoning province and increasing trends in Jilin and especially in Heilongjiang province, which increased by 0.11. Spatial differences were visible in different periods, and the most obvious increase was found in the period 2001-2010. The areas with high values of K shifted northeastward over the past 50 years, indicating more efficient use of agricultural climatic resources in Northeast China.

  12. Estimating least-developed countries' vulnerability to climate-related extreme events over the next 50 years.

    PubMed

    Patt, Anthony G; Tadross, Mark; Nussbaumer, Patrick; Asante, Kwabena; Metzger, Marc; Rafael, Jose; Goujon, Anne; Brundrit, Geoff

    2010-01-26

    When will least developed countries be most vulnerable to climate change, given the influence of projected socio-economic development? The question is important, not least because current levels of international assistance to support adaptation lag more than an order of magnitude below what analysts estimate to be needed, and scaling up support could take many years. In this paper, we examine this question using an empirically derived model of human losses to climate-related extreme events, as an indicator of vulnerability and the need for adaptation assistance. We develop a set of 50-year scenarios for these losses in one country, Mozambique, using high-resolution climate projections, and then extend the results to a sample of 23 least-developed countries. Our approach takes into account both potential changes in countries' exposure to climatic extreme events, and socio-economic development trends that influence countries' own adaptive capacities. Our results suggest that the effects of socio-economic development trends may begin to offset rising climate exposure in the second quarter of the century, and that it is in the period between now and then that vulnerability will rise most quickly. This implies an urgency to the need for international assistance to finance adaptation. PMID:20080585

  13. Estimating least-developed countries’ vulnerability to climate-related extreme events over the next 50 years

    PubMed Central

    Patt, Anthony G.; Tadross, Mark; Nussbaumer, Patrick; Asante, Kwabena; Metzger, Marc; Rafael, Jose; Goujon, Anne; Brundrit, Geoff

    2010-01-01

    When will least developed countries be most vulnerable to climate change, given the influence of projected socio-economic development? The question is important, not least because current levels of international assistance to support adaptation lag more than an order of magnitude below what analysts estimate to be needed, and scaling up support could take many years. In this paper, we examine this question using an empirically derived model of human losses to climate-related extreme events, as an indicator of vulnerability and the need for adaptation assistance. We develop a set of 50-year scenarios for these losses in one country, Mozambique, using high-resolution climate projections, and then extend the results to a sample of 23 least-developed countries. Our approach takes into account both potential changes in countries’ exposure to climatic extreme events, and socio-economic development trends that influence countries’ own adaptive capacities. Our results suggest that the effects of socio-economic development trends may begin to offset rising climate exposure in the second quarter of the century, and that it is in the period between now and then that vulnerability will rise most quickly. This implies an urgency to the need for international assistance to finance adaptation. PMID:20080585

  14. Commentary on 50 years of research at the NBRL, Boston, Massachusetts.

    PubMed

    Valeri, C R; Giorgio, G R

    2016-02-01

    Research at the NBRL, Boston, MA over the past 50 years assessed the survival and function of RBC and platelets and the function of plasma clotting proteins. Liquid preserved RBC can be stored at 4 °C for only 2 weeks to maintain a 24-hour posttransfusion survival value of 75%, moderately impaired oxygen transport function after transfusion, exert a hemostatic effect, and increase the plasma volume. Liquid preserved platelets can be stored at room temperature with agitation for only 2 days to have acceptable in vivo survival 2 hours following transfusion, normal lifespan, and a hemostatic effect to reduce the bleeding time in thrombocytopenic patients. RBCs frozen with 40% W/V glycerol at -80 °C for at least 10 years, thawed, and deglycerolized in the Haemonetics ACP215 can be stored in Nutricel at 4 °C for 2 weeks with a 24-hour posttransfusion survival of 75%, moderately impaired oxygen transport function after transfusion, exert a hemostatic effect and increase the plasma volume. Leukoreduced single donor platelets treated with 6% DMSO, the supernatant DMSO removed prior to freezing at -80 °C for 2 years, thawed, and diluted with 0.9% NaCl or AB plasma have a bimodal population of platelets: one population has reduced in vivo survival, but increased hemostatic effect and the other has normal in vivo survival. AB plasma can be stored at -80 °C for at least 14 years, thawed, and stored at 4 °C for 24 hours with acceptable in vitro function of clotting proteins. The data reported by the NBRL, Boston, Mass. over the past 50 years and the 15-year experience by the Netherlands military now recommend that FDA, ARC, HHS and DOD should support the use of universal donor frozen group O Rh positive and group O Rh negative RBC, frozen group O platelets and frozen AB plasma from male donors. The frozen blood products will eliminate the severe adverse events of mortality and morbidity associated with the current FDA approved red blood cell products, platelet

  15. Case Records of the Massachusetts General Hospital. Case 30-2015: A 50-Year-Old Man with Cardiogenic Shock.

    PubMed

    Wheeler, Thurman M; Baker, Joshua N; Chad, David A; Zilinski, Jodi L; Verzosa, Stacey; Mordes, Daniel A

    2015-09-24

    A 50-year-old man with a history of cardiomyopathy and progressive muscle weakness was admitted with cardiogenic shock. Electroencephalography showed total suppression of cerebral activity; ventilator support was withdrawn, and he died. An autopsy was performed. PMID:26398074

  16. Non-labile silver species in biosolids remain stable throughout 50 years of weathering and ageing.

    PubMed

    Donner, E; Scheckel, K; Sekine, R; Popelka-Filcoff, R S; Bennett, J W; Brunetti, G; Naidu, R; McGrath, S P; Lombi, E

    2015-10-01

    Increasing commercial use of nanosilver has focussed attention on the fate of silver (Ag) in the wastewater release pathway. This paper reports the speciation and lability of Ag in archived, stockpiled, and contemporary biosolids from the UK, USA and Australia, and indicates that biosolids Ag concentrations have decreased significantly over recent decades. XANES revealed the importance of reduced-sulfur binding environments for Ag speciation in materials ranging from freshly produced sludge to biosolids weathered under ambient environmental conditions for more than 50 years. Isotopic dilution with (110 m)Ag showed that Ag was predominantly non-labile in both fresh and aged biosolids (13.7% mean lability), with E-values ranging from 0.3 to 60 mg/kg and 5 mM CaNO3 extractable Ag from 1.2 to 609 μg/kg (0.002-3.4% of the total Ag). This study indicates that at the time of soil application, biosolids Ag will be predominantly Ag-sulfides and characterised by low isotopic lability. PMID:26021819

  17. Curly tail: a 50-year history of the mouse spina bifida model.

    PubMed

    van Straaten, H W; Copp, A J

    2001-04-01

    This paper reviews 50 years of progress towards understanding the aetiology and pathogenesis of neural tube defects (NTD) in the curly tail (ct) mutant mouse. More than 45 papers have been published on various aspects of curly tail with the result that it is now the best understood mouse model of NTD pathogenesis. The failure of closure of the spinal neural tube, which leads to spina bifida in this mouse, has been traced back to a tissue-specific defect of cell proliferation in the tail bud of the E9.5 embryo. This cell proliferation defect results in a growth imbalance in the caudal region that generates ventral curvature of the body axis. Neurulation movements are opposed, leading to delayed neuropore closure and spina bifida, or tail defects. It is interesting to reflect that these advances have been achieved in the absence of information on the nature of the ct gene product, which remains unidentified. In addition to the principal ct gene, which maps to distal Chromosome 4, the curly tail phenotype is influenced by several modifier genes and by environmental factors. NTD in curly tail are resistant to folic acid, as is thought to be the case in 30% of human NTD, whereas they can be prevented by myo-inositol. These and other features of NTD in this system bear striking similarities to the situation in humans, making curly tail a model for understanding a sub-type folic acid-resistant human NTD. PMID:11396850

  18. Earth Observations from Space: The First 50 Years of Scientific Achievements

    NASA Astrophysics Data System (ADS)

    Minster, B.; Campbell, J. W.; Dozier, J.; Fleming, J. R.; Gille, J. C.; Hartmann, D. L.; Jezek, K.; Kidder, S.; Ramankutty, N.; Thompson, A.; Ustin, S. L.; Yoder, J.; Probst, L.; Mengelt, C.

    2007-12-01

    Observing the Earth from space over the last five decades has fundamentally transformed the way people view our home planet. The image of the "blue marble" is taken for granted now, but it was revolutionary when it was first taken in 1972 by the crew on Apollo 17. Since then, the capability to look at Earth from space has grown increasingly sophisticated and evolved from simple photographs to quantitative measurements of Earth properties such as temperature, atmospheric gases, and exact elevation of land and ocean. Consequently, every new method of imaging the Earth from space has resulted in scientific accomplishments that have enabled new discoveries, transformed the field, refined scientific understanding, opened new avenues of research, or provided important societal benefits by improving the predictability of Earth system processes. This National Research Council (NRC) study highlights selected scientific achievements made possible by the first 50 years of Earth satellite observations by space-faring nations. It follows on a recent report from the NRC entitled "Earth Science and Applications from Space: National Imperatives for the Next Decade and Beyond" (NRC 2007), also referred to as the "decadal study."

  19. Attitudes to and experience of dental care among 50-year-olds in two Swedish counties.

    PubMed

    Unell, L; Söderfeldt, B; Halling, A; Birkhed, D

    1999-01-01

    The aim of this study was to investigate attitudes to and experiences of dental care in a population, born 1942. The following items were studied: opinions of general and oral health, attitudes to and experiences of dental care, dental care habits, experiences of latest visit to a dentist, tobacco habits and use of various dental hygiene articles. A cross-sectional mail questionnaire was sent in 1992 to all 50-year-olds in two Swedish counties, Orebro and Ostergotland, totally 8888 persons; the response rate was 71%. Of the population 89%, indicated good health. Satisfaction with dental care was high, 94%. 26% stated attendance to a dentist twice or more per year, and 64% at least once a year. As to expenses, 78% paid less than 1000 SEK the last year. Concerning the latest visit, 38% reported painless treatment, 37% no inconvenience, and 55% good care. The duration of the latest visit included on an average 27 min in travel time, 7 min in waiting time and 27 min in treatment time. Information about oral hygiene was given to 29% and about cost for treatment to 47% of the interviewed. There were 28% daily smokers. Snuff was daily used by 10% of the males. Toothbrushing twice a day with fluoride toothpaste seemed to be the standard oral hygiene procedure and was reported by 80% of the respondents. PMID:10431344

  20. Earth Observations from Space: The First 50 Years of Scientific Achievements

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Observing Earth from space over the past 50 years has fundamentally transformed the way people view our home planet. The image of the "blue marble" is taken for granted now, but it was revolutionary when taken in 1972 by the crew on Apollo 17. Since then the capability to look at Earth from space has grown increasingly sophisticated and has evolved from simple photographs to quantitative measurements of Earth properties such as temperature, concentrations of atmospheric trace gases, and the exact elevation of land and ocean. Imaging Earth from space has resulted in major scientific accomplishments; these observations have led to new discoveries, transformed the Earth sciences, opened new avenues of research, and provided important societal benefits by improving the predictability of Earth system processes. This report highlights the scientific achievements made possible by the first five decades of Earth satellite observations by space-faring nations. It follows on a recent report from the National Research Council (NRC) entitled Earth Science and Applications from Space: National Imperatives for the Next Decade and Beyond, also referred to as the "decadal survey." Recognizing the increasing need for space observations, the decadal survey identifies future directions and priorities for Earth observations from space. This companion report was requested by the National Aeronautics and Space Administration (NASA) to highlight, through selected examples, important past contributions of Earth observations from space to our current understanding of the planet.

  1. Occupational Exposure to Hydrazine and Subsequent Risk of Lung Cancer: 50-Year Follow-Up

    PubMed Central

    Morris, Joan K.; Wald, Nicholas J.; Springett, Anna L.

    2015-01-01

    Purpose Hydrazine is carcinogenic in animals, but there is inadequate evidence to determine if it is carcinogenic in humans. This study aimed to evaluate the association between hydrazine exposure and the risk of lung cancer. Methods The cause specific mortality rates of a cohort of 427 men who were employed at an English factory that produced hydrazine between 1945 and 1971 were compared with national mortality rates. Results By the end of December 2012 205 deaths had occurred. For men in the highest exposure category with greater than two years exposure and after more than ten years since first exposure the relative risks compared with national rates were: 0.85 (95% CI: 0.18–2.48) for lung cancer, 0.61 (95% CI: 0.07–2.21) for cancers of the digestive system, and 0.44 (95% CI: 0.05–1.57) for other cancers. Conclusions After 50 years of follow up, the results provide no evidence of an increased risk of death from lung cancer or death from any other cause. PMID:26394402

  2. 50 Years of renal physiology from one man and the perfused tubule: Maurice B. Burg.

    PubMed

    Hamilton, Kirk L; Moore, Antoni B

    2016-08-01

    Technical advancements in research techniques in science are made in slow increments. Even so, large advances from insight and hard work of an individual with a single technique can have astonishing ramifications. Here, we examine the impact of Dr. Maurice B. Burg and the isolated perfused renal tubule technique and celebrate the 50th anniversary of the publication by Dr. Burg and his colleagues of their landmark paper in the American Journal of Physiology in 1966. In this study, we have taken a scientific visualization approach to study the scientific contributions of Dr. Burg and the isolated perfused tubule preparation as determining research impact by the number of research students, postdoctoral fellows, visiting scientists, and national and international collaborators. Additionally, we have examined the research collaborations (first and second generation scientists), established the migrational visualization of the first generation scientists who worked directly with Dr. Burg, quantified the metrics indices, identified and quantified the network of coauthorship of the first generation scientists with their second generation links, and determined the citations analyses of outputs of Dr. Burg and/or his first generation collaborators as coauthors. We also review the major advances in kidney physiology that have been made with the isolated perfused tubule technique. Finally, we are all waiting for the discoveries that the isolated perfused preparation technique will bring during the next 50 years. PMID:27122544

  3. Applications of mass spectrometry in drug metabolism: 50 years of progress.

    PubMed

    Wen, Bo; Zhu, Mingshe

    2015-02-01

    Mass spectrometry plays a pivotal role in drug metabolism studies, which are an integral part of drug discovery and development nowadays. Metabolite identification has become critical to understanding the metabolic fate of drug candidates and to aid lead optimization with improved metabolic stability, toxicology and efficacy profiles. Ever since the introduction of atmospheric ionization techniques in the early 1990s, liquid chromatography coupled with mass spectrometry (LC/MS) has secured a central role as the predominant analytical platform for metabolite identification as LC and MS technologies continually advanced. In this review, we discuss the evolution of both MS technology and its applications over the past 50 years to meet the increasing demand of drug metabolism studies. These advances include ionization sources, mass analyzers, a wide range of MS acquisition strategies and data mining tools that have substantially accelerated the metabolite identification process and changed the overall drug metabolism landscape. Exemplary applications for characterization and identification of both small-molecule xenobiotics and biological macromolecules are described. In addition, this review discusses novel MS technologies and applications, including xenobiotic metabolomics that hold additional promise for advancing drug metabolism research, and offers thoughts on remaining challenges in studying the metabolism and disposition of drugs and other xenobiotics. PMID:25639893

  4. Incidence and Mortality after Distal Radius Fractures in Adults Aged 50 Years and Older in Korea

    PubMed Central

    2016-01-01

    The purpose of this study was to assess the incidence and mortality of distal radius fracture among patients 50 years of age and older with diagnosis code (ICD10; S52.5, S52.6) and treatment code using a nationwide claims database from 2008 to 2012. All patients were followed using patient identification code to identify deaths. Standardized mortality ratios (SMRs) of distal radius fracture were calculated based on age and gender-specific rates in the entire Korean population. The number of distal radius fractures increased by 54.2% over the 5-year study (48,145 in 2008 and 74,240 in 2012). The incidence of distal radius fracture increased from 367.4/100,000 in 2008 to 474.1/100,000 in 2012. The cumulative mortality rate over the first 12 months after distal radius fracture was decreased from 2.0% (968/48,145) in 2008 to 1.4% (1,045/74,240) in 2012. The mean year mortality over 5 years in men (2.6%, 1,279/50,128) over the first 12 months was 1.7-times higher than in women (1.5%, 3,952/257,045). The mean of SMR of distal radius fracture at 1 year post-fracture was 1.45 in men and 1.17 in women. This study using a nationwide database demonstrates that the distal radius fractures are increasing with a decreasing mortality in Korea. PMID:27051250

  5. Influenza Vaccine-Induced CNS Demyelination in a 50-Year-Old Male

    PubMed Central

    Sacheli, Aaron; Bauer, Raymond

    2014-01-01

    Patient: Male, 50 Final Diagnosis: Acute post-vaccination CNS demyelinating disorder Symptoms: Blurred vision • hemiparesis • hemiplegia • hypertonia • itching • paresthesia Medication: — Clinical Procedure: MRI Specialty: Neurology Objective: Rare disease Background: There are several categories of primary inflammatory demyelinating disorders, which comprise clinically similar neurologic sequelae. Of interest, clinically isolated syndrome (CIS) and acute disseminated encephalomyelitis (ADEM) are 2 demyelinating conditions of the central nervous system (CNS), whose clinical similarity pose a significant challenge to definitive diagnosis. Yet, both remain important clinical considerations in patients with neurologic signs and symptoms in the context of recent vaccination. Case Report: We report a case of a 50-year-old Caucasian male with a course of progressive, focal, neurologic deficits within 24 h after receiving the influenza vaccine. Subsequent work-up revealed the possibility of an acute central nervous system (CNS) demyelinating episode secondary to the influenza vaccine, best described as either CIS or ADEM. Conclusions: Case reports of CNS demyelination following vaccinations have been previously noted, most often occurring in the context of recent influenza vaccination. This report serves to document a case of CNS demyelination occurring 24 h after influenza vaccination in a middle-aged patient, and will describe some salient features regarding the differential diagnosis of CIS and ADEM, as well as their potential management. PMID:25175754

  6. Substantial glacier mass loss in the Tien Shan over the past 50 years

    NASA Astrophysics Data System (ADS)

    Farinotti, Daniel; Longuevergne, Laurent; Moholdt, Geir; Duethmann, Doris; Mölg, Thomas; Bolch, Tobias; Vorogushyn, Sergiy; Güntner, Andreas

    2015-09-01

    Populations in Central Asia are heavily dependent on snow and glacier melt for their water supplies. Changes to the glaciers in the main mountain range in this region, the Tien Shan, have been reported over the past decade. However, reconstructions over longer, multi-decadal timescales and the mechanisms underlying these variations--both required for reliable future projections--are not well constrained. Here we use three ensembles of independent approaches based on satellite gravimetry, laser altimetry, and glaciological modelling to estimate the total glacier mass change in the Tien Shan. Results from the three approaches agree well, and allow us to reconstruct a consistent time series of annual mass changes for the past 50 years at the resolution of individual glaciers. We detect marked spatial and temporal variability in mass changes. We estimate the overall decrease in total glacier area and mass from 1961 to 2012 to be 18 +/- 6% and 27 +/- 15%, respectively. These values correspond to a total area loss of 2,960 +/- 1,030 km2, and an average glacier mass-change rate of -5.4 +/- 2.8 Gt yr-1. We suggest that the decline is driven primarily by summer melt and, possibly, linked to the combined effects of general climatic warming and circulation variability over the north Atlantic and north Pacific.

  7. Thoracic outlet syndrome: a 50-year experience at Baylor University Medical Center

    PubMed Central

    Kourlis, Harry

    2007-01-01

    During the past 5 decades, the recognition and management of thoracic outlet syndrome (TOS) have evolved. This article elucidates these changes and improvements in the diagnosis and management of TOS at Baylor University Medical Center. The most remarkable change over the past 50 years is the use of nerve conduction velocity to diagnose and monitor patients with nerve compression. Recognition that procedures such as breast implantation and median sternotomy may produce TOS has been revealing. Prompt thrombolysis followed by surgical venous decompression for Paget-Schroetter syndrome has markedly improved results compared with the conservative anticoagulation approach; thrombolysis and prompt first rib resection is the optimal treatment for most patients with Paget-Schroetter syndrome. Complete first rib extirpation at the initial procedure markedly reduces the incidence of recurrent neurologic symptoms or the need for a second procedure. Chest pain or pseudoangina can be caused by TOS. Dorsal sympathectomy is helpful for patients with sympathetic maintained pain syndrome or causalgia and patients with recurrent TOS symptoms who need a second procedure. PMID:17431445

  8. Unilateral lower limb lymphedema resulting from a heart surgery performed 50 years prior

    PubMed Central

    Onoda, Satoshi; Miura, Yuki; Sugiyama, Narushi

    2015-01-01

    Introduction Lymphedema is classified into two main types: secondary lymphedema accompanied by lymph node excision surgery or radiotherapy; and idiopathic lymphedema. Here we experienced a very rare case of lymphatic edema resulting from cardiac surgery that the patient underwent 50 years previously. Presentation of case A 62-year-old woman experienced progressive unilateral lower leg lymphedema for recent years. After undergoing cardiac surgery at another hospital at the age of 12 years, she gradually developed left lower leg edema. The cause of the edema was unclear and it remained untreated. Her edema symptoms gradually worsened in recent years, so she consulted the plastic surgery division of our hospital. Discusssion Perhaps the lymphatic structures of affected individuals differ prior to disease onset. If the mechanism of lymphatic edema outbreak is elucidated, patients needing conservative and surgical therapy might be more easily identified. Knowing the outbreak mechanism of lymphatic edema would definitely ease the investigation of an unconventional case like this one. Conservative treatments for lymphedema, such as self-massage and compression therapy using garments, were immediately started. With these treatments, the leg volume and edema symptoms reduced. Conclusion The research on the cause of this case may be important step for elucidating the source of secondary lymphatic edema. PMID:26719996

  9. Aging in Prader-Willi syndrome: twelve persons over the age of 50 years.

    PubMed

    Sinnema, Margje; Schrander-Stumpel, Constance T R M; Maaskant, Marian A; Boer, Harm; Curfs, Leopold M G

    2012-06-01

    The life expectancy of persons with Prader-Willi syndrome (PWS) has increased in recent years. Because of the paucity of reports on older persons with PWS, the natural history, the onset, and type of age-related problems are poorly understood. Twelve persons with a genetically confirmed diagnosis of PWS aged over 50 years are described (4 deletion; 8 mUPD). Data on physical, behavioral, psychiatric, and aging characteristics were collected through semi-structured interviews with the individuals with PWS and their main carers. Cardiovascular diseases, diabetes, dermatological, and orthopedic problems were common physical complaints in older people with PWS. Functioning in activities of daily living, psychological functioning, physical functions, and care dependence were substantially worse in the older age group (50+) compared to the control group (18-49 years). Seven out of eight persons with mUPD had a history of psychiatric illness. Behavioral problems were observed in the older age group. Given the combination of age-related physical morbidity, physical appearance, behavioral and psychiatric problems, and functional decline in our cohort, we hypothesize that premature aging occurs in PWS. The care for older people with PWS requires a lifespan approach that recognizes the presence, progression, and consequences of specific morbidity. Special medical surveillance of people with PWS from 40 years onwards would ensure that intervention and support is offered with respect to specific areas of decline at the earliest possible time. PMID:22585395

  10. Ceremony at CCAS to kick off year-long celebration of 50 years of space launches

    NASA Technical Reports Server (NTRS)

    1999-01-01

    At Cape Canaveral Air Station's (CCAS) Complex 3/4, officials held a ceremony kicking off a year-long series of events commemorating 50 years of launches from the Space Coast that began with the Bumper rockets. At right, Norris Gray, a Bumper Program veteran, unveils a street sign that will be used to mark the road leading to the launch complex from which Bumper was launched. Seen on the stage are, left to right, Lt. Col. Randall K. Horn (at the podium), Commander, CCAS; Congressman David Weldon, 15th Congressional District of the State of Florida; Lieutenant Governor of the State of Florida Frank T. Brogan; Center Director Roy D. Bridges; and Executive Director Edward F. Gormel, Joint Performance Management Office. Also present (but not seen) is Brig. Gen. Donald P. Pettit, Commander, 45th Space Wing. After six Bumper launches at White Sands Proving Grounds, N.M., and a failed Bumper 7, a successful Bumper 8 lifted off July 24, 1950, from Complex 3/4 to conduct aerodynamic investigations around Mach 7 at relatively low altitudes. The kick-off event also inaugurated a student art contest to design a commemorative etching. The winning artwork will be permanently displayed on a 24-inch black granite square in the U.S. space Walk hall of Fame in Titusville, Fla.

  11. Orthogonal electrocardiogram, apex cardiogram, and atrial sound in normotensive and hypertensive 50-year-old men.

    PubMed Central

    Wikstrand, J; Berglund, G; Wilhelmsen, L; Wallentin, I

    1976-01-01

    The prevalence of signs of heart involvement was studied non-invasively in a group of untreated hypertensives (n=35) and a reference group (n=73), all derived from a random population sample of 50-year-old men. Signs of left ventricular hypertrophy were studied by means of orthogonal electrocardiography and conventional electrocardiography. Signs of decreased distensibility of the left ventricle were studied by apex cardiography and registration of atrial sounds. Left ventricular hypertrophy among hypertensives was significantly more common according to orthogonal electrocardiography (33%) than according to conventional electrocardiography (9%), indicating that the former may be a better method for detection of left ventricular hypertrophy than the latter. In the hypertension group the amplitude of the R wave in lead X on orthogonal electrocardiography was positively correlated to casual diastolic blood pressure (r=0-40) and to diastolic blood pressure after one hour's rest (r=0-65). The degree of pressure load leading to left ventricular hypertrophy seems to be better reflected by resting than by casual blood pressure. There was no hypertensive subject with both signs of left ventricular hypertrophy on orthogonal electrocardiography and either an a/H ratio over 15 per cent or an abnormal atrial sound, indicating two different forms of cardiac involvement as the result of hypertension. Casual blood pressures became normal during rest in hypertensives with a/H ratio over 15 per cent on apex cardiography or abnormal atrial sound, not in hypertensives with signs of left ventricular hypertrophy on orthogonal electrocardiography. PMID:135571

  12. How far we have come in the last 50 years in smoking attitudes and actions.

    PubMed

    Burns, David

    2014-02-01

    Dramatic changes in smoking behavior and attitudes about smoking have occurred over the 50-year interval since the release of the 1964 smoking and health report to the Surgeon General. Between 1965 and 2011, adult prevalence of cigarette smoking fell from 51.9 to 21.6% among men and from 33.9 to 16.5% among women, with an increasing fraction of smokers who do not smoke every day. Federal taxes have increased from $0.08 in 1965 to $1.01, with even larger increases in many state taxes. Workplace restrictions on smoking have increased from only 3% of workers protected by workplace smoking bans in 1986 (e.g., those working in fireworks factories) to more than 70% of workers being protected in 1999. Equally dramatic changes have occurred in restrictions on smoking in the home. The evaporation of the remaining societal support for smoking may be an important part of the "end game" for cigarette smoking in the United States. PMID:24575990

  13. Air pollution in the last 50 years - From local to global

    NASA Astrophysics Data System (ADS)

    Fenger, Jes

    Air pollution in the industrialised world has in the last 50 years undergone drastic changes. Until after World War II the most important urban compound was sulphur dioxide combined with soot from the use of fossil fuels in heat and power production. When that problem was partly solved by cleaner fuels, higher stacks and flue gas cleaning in urban areas, the growing traffic gave rise to nitrogen oxides and volatile organic compounds and in some areas photochemical air pollution, which may be abated by catalytic converters. Lately the interest has centred on small particles and more exotic organic compounds that can be detected with new sophisticated analytical techniques. Simultaneously with the development in compounds, the time and geographical scale of interest have increased. First to transboundary air pollution, which in decades and on continents can degrade ecosystems, later to the depletion of the ozone layer and especially to the increasing greenhouse effect with climate change that will change the conditions for nature and mankind on the entire globe. The possibilities to study these large scale phenomena have been greatly enhanced by the development of electronic computers that can handle large data sets and calculate various scenarios. All these processes take place in the thin layer of gases around the Earth, the atmosphere. Although the abatement is often restricted to a single aspect, they are often connected and should when possible be treated as whole.

  14. The Demoiselle of X-Inactivation: 50 Years Old and As Trendy and Mesmerising As Ever

    PubMed Central

    Morey, Céline; Avner, Philip

    2011-01-01

    In humans, sexual dimorphism is associated with the presence of two X chromosomes in the female, whereas males possess only one X and a small and largely degenerate Y chromosome. How do men cope with having only a single X chromosome given that virtually all other chromosomal monosomies are lethal? Ironically, or even typically many might say, women and more generally female mammals contribute most to the job by shutting down one of their two X chromosomes at random. This phenomenon, called X-inactivation, was originally described some 50 years ago by Mary Lyon and has captivated an increasing number of scientists ever since. The fascination arose in part from the realisation that the inactive X corresponded to a dense heterochromatin mass called the “Barr body” whose number varied with the number of Xs within the nucleus and from the many intellectual questions that this raised: How does the cell count the X chromosomes in the nucleus and inactivate all Xs except one? What kind of molecular mechanisms are able to trigger such a profound, chromosome-wide metamorphosis? When is X-inactivation initiated? How is it transmitted to daughter cells and how is it reset during gametogenesis? This review retraces some of the crucial findings, which have led to our current understanding of a biological process that was initially considered as an exception completely distinct from conventional regulatory systems but is now viewed as a paradigm “par excellence” for epigenetic regulation. PMID:21811421

  15. The Axon Initial Segment, 50Years Later: A Nexus for Neuronal Organization and Function.

    PubMed

    Leterrier, Christophe

    2016-01-01

    The axon initial segment is a highly specialized neuronal compartment, identified almost 50years ago by the pioneers of electron microscopy. Located in the first 50μm of the axon, it contains unique cytoskeletal features and concentrates a repertoire of specific scaffold and membrane proteins that assembles just after axon determination. The axon initial segment (AIS) supports two crucial physiological functions of the mature neuron: first, it generates and shapes the action potential. Second, it separates the cell body from the axon, preserving the molecular identity of each compartment. In addition to a diffusion barrier restricting membrane proteins and lipids exchange, an intracellular filter has been proposed that could selectively exclude somatodendritic vesicles and recruit axonal cargoes. Finally, the AIS scaffold is capable of morphological plasticity during development or in response to network activity. These changes directly impact the neuron excitability, allowing an adaptive and homeostatic response. These plastic electrogenic properties, as well as the regulation of protein transport to and from the axon, may have important implications in several neuropathological contexts where the AIS structure is altered. Fifty years after its first characterization, the AIS thus emerges as a nexus for both neuronal organization and physiology. PMID:26781833

  16. 50 Years of Electronic Check Out and Launch Systems at Kennedy Space Center

    NASA Technical Reports Server (NTRS)

    Starr, Stanley O.

    2007-01-01

    When NASA was created in 1958 one of the elements incorporated into this new agency was the Army Ballistic Missile Agency (ABMA) in Huntsville, AL and its subordinate Missile Firing Laboratory (MFL) in Cape Canaveral. Under NASA, the MFL became the Launch Operations Directorate of the George C. Marshall Space Flight Center in Huntsville, but expanding operations in the build up to Apollo dictated that it be given the status of a full fledged Center in July, 1 962[ 1]. The next year it was renamed the John F. Kennedy Space Center (KS C) after the president whose vision transformed its first decade of operation. The ABMA was under the technical leadership of Dr. Werner Von Braun. The MEL was run by his deputy Dr. Kurt Debus, an electrical engineer whose experience in the field began in the early days of V-2 testing in war time Germany. In 1952 a group led by Debus arrived in Cape Canaveral to begin test launches of the new Redstone missile [2]. During the 50's, The MFL built several launch complexes and tested the Redstone, Jupiter and Jupiter C missiles. This small experienced team of engineers and technicians formed the seed from which has grown the KSC team of today. This article briefly reviews the evolution of the KSC electronic technologies for integration, check-out and launch of space vehicles and payloads during NASA's first 50 years.

  17. Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old

    PubMed Central

    Tavares, A. B. W.; Micmacher, E.; Biesek, S.; Assumpção, R.; Redorat, R.; Veloso, U.; Vaisman, M.; Farinatti, P. T. V.; Conceição, F.

    2013-01-01

    Growth hormone (GH) use has been speculated to improve physical capacity in subjects without GH deficiency (GHD) through stimulation of collagen synthesis in the tendon and skeletal muscle, which leads to better exercise training and increased muscle strength. In this context, the use of GH in healthy elderly should be an option for increasing muscle strength. Our aim was to evaluate the effect of GH therapy on muscle strength in healthy men over 50 years old. Fourteen healthy men aged 50–70 years were evaluated at baseline for body composition and muscle strength (evaluated by leg press and bench press exercises, which focus primarily on quadriceps—lower body part and pectoralis major—upper body part—muscles, resp.). Subjects were randomised into 2 groups: GH therapy (7 subjects) and placebo (7 subjects) and reevaluated after 6 months of therapy. Thirteen subjects completed the study (6 subjects in the placebo group and 7 subjects in the GH group). Subjects of both groups were not different at baseline. After 6 months of therapy, muscle strength in the bench press responsive muscles did not increase in both groups and showed a statistically significant increase in the leg press responsive muscles in the GH group. Our study demonstrated an increase in muscle strength in the lower body part after GH therapy in healthy men. This finding must be considered and tested in frail older populations, whose physical incapacity is primarily caused by proximal muscle weakness. The trial was registered with NCT01853566. PMID:24382963

  18. The political economy of maize production and poverty reduction in Zambia: analysis of the last 50 years.

    PubMed

    Hanjra, Munir A; Culas, Richard J

    2011-01-01

    Poverty and food security are endemic issues in much of sub-Saharan Africa. To eradicate extreme poverty and hunger in the region remains a key Millennium Development Goal. Many African governments have pursued economic reforms and agricultural policy interventions in order to accelerate economic growth that reduces poverty faster. Agricultural policy regimes in Zambia in the last 50 years (1964–2008) are examined here to better understand their likely impact on food security and poverty, with an emphasis on the political economy of maize subsidy policies. The empirical work draws on secondary sources and an evaluation of farm household data from three villages in the Kasama District of Zambia from 1986/87 and 1992/93 to estimate a two-period econometric model to examine the impact on household welfare in a pre- and post-reform period. The analysis shows that past interventions had mixed effects on enhancing the production of food crops such as maize. While such reforms were politically popular, it did not necessarily translate into household-level productivity or welfare gains in the short term. The political economy of reforms needs to respond to the inherent diversity among the poor rural and urban households. The potential of agriculture to generate a more pro-poor growth process depends on the creation of new market opportunities that most benefit the rural poor. The state should encourage private sector investments for addressing infrastructure constraints to improve market access and accelerate more pro-poor growth through renewed investments in agriculture, rural infrastructure, gender inclusion, smarter subsidies and regional food trade. However, the financing of such investments poses significant challenges. There is a need to address impediments to the effective participation of public private investors to generate more effective poverty reduction and hunger eradication programmes. This article also explores the opportunities for new public

  19. Spatiotemporal variations of precipitation extremes of China during the past 50 years (1960-2009)

    NASA Astrophysics Data System (ADS)

    Chi, Xiaoxiao; Yin, Zhan'e.; Wang, Xuan; Sun, Yuke

    2016-05-01

    Extreme weather events have become more frequent and intense under global warming in recent years, which has attracted much attention of scholars at home and abroad. In this paper, we used data sets of daily precipitation recorded at 499 meteorological stations to analyze the temporal and spatial variations of precipitation extremes in China over the past 50 years (1960-2009). Through the comparison of detrended fluctuation analysis (DFA) and the percentile method, DFA was selected to define the thresholds of precipitation extremes in China. Temporal variations of extreme precipitation amount, frequency, and intensity were analyzed in four major regions: Northwest China, the Qinghai-Tibet region, North China, and South China. Spatial distributions were obtained by the Kriging interpolation method, and then, we examined the varying tendencies of extreme precipitation amount, frequency, and intensity by the Mann-Kendall test. The results show that increasing trends are dominant for all indices over China; extreme precipitation amount and frequency appear to have risen since 1970-1979, but there are some regional differences. The Qinghai-Tibet region and South China have an ascending trend, and Northwest China maintains balance while North China has a descending trend. The amount and intensity of precipitation extremes are decreasing from southeastern coastal areas to northwestern inlands, and the frequency of precipitation extremes is randomly distributed. However, they are all high in the Sichuan Basin, the middle and lower Yangtze River, and the southern part of South China. Trends of most stations are statistically insignificant, but the percentage of stations with a significant increased trend in the Qinghai-Tibet region is larger than that of other regions.

  20. 50 years of DNA ‘Breathing’: Reflections on Old and New Approaches

    PubMed Central

    von Hippel, Peter H.; Johnson, Neil P.; Marcus, Andrew H.

    2015-01-01

    Summary The coding sequences for genes, and much other regulatory information involved in genome expression, are located ‘inside’ the DNA duplex. Thus the ‘macromolecular machines’ that read-out this information from the base sequence of the DNA must somehow access the DNA ‘interior’. Double-stranded (ds) DNA is a highly structured and cooperatively stabilized system at physiological temperatures, but is also only marginally stable and undergoes a cooperative ‘melting phase transition’ at temperatures not far above physiological. Furthermore, due to its length and heterogeneous sequence, with AT-rich segments being less stable than GC-rich segments, the DNA genome ‘melts’ in a multistate fashion. Therefore the DNA genome must also manifest thermally driven structural (‘breathing’) fluctuations at physiological temperatures that should reflect the heterogeneity of the dsDNA stability near the melting temperature. Thus many of the breathing fluctuations of dsDNA are likely also to be sequence dependent, and could well contain information that should be ‘readable’ and useable by regulatory proteins and protein complexes in site-specific binding reactions involving dsDNA ‘opening’. Our laboratory has been involved in studying the breathing fluctuations of duplex DNA for about 50 years. In this ‘Reflections’ article we present a relatively chronological overview of these studies, starting with the use of simple chemical probes (such as hydrogen exchange, formaldehyde and simple DNA ‘melting’ proteins) to examine the local stability of the dsDNA structure, and culminating in sophisticated spectroscopic approaches that can be used to monitor the breathing-dependent interactions of regulatory complexes with their duplex DNA targets in ‘real time’. PMID:23840028

  1. Southern Alpine floods of the last 50 years recorded in the sediment record from Lago Maggiore

    NASA Astrophysics Data System (ADS)

    Kämpf, L.; Brauer, A.; Guilizzoni, P.; Lami, A.

    2009-04-01

    The frequency of extreme floods is increasingly discussed under meteorological and anthropogenic forcing aspects because of their potentially disastrous consequences. Existing hydrological and meteorological instrumental data are, however, limited to rather short time scales. Records of natural geoarchives like lacustrine sediments, in contrast, reach much further back in time and reflect climate changes and environmental processes. In particular, extreme floods give an imprint to lake sediment records. The sediment loaded stream enters the lake water and eventually is deposited as a detrital layer. Here we present a multicore study from Pallanza Basin in the western part of Lago Maggiore. Major detrital layers are triggered mainly by flooding events of the Toce River. Through microfacies analyses of petrographic thin-sections and high-resolution element scanning techniques several detrital layers have been identified and correlated to historical flood events of the last 50 years. For this time interval fifteen flood event layers have been identified in the sediment record. Their thicknesses range from 0.5 to more than 15 mm. Noticeable is a rise of flooding events in the 1970s, which might be related to a change in atmospheric circulation patterns as documented in the NAO index. Comparison of these detrital layers in different cores allowed reconstructing their spatial distribution within the Pallanza Basin. Two detrital layers are clearly not related to regional floods but were generated by local slope failure or debris flows. This work is combined with studies of biological remains and pigment analyses, proving evidence of historical changes in the trophic state, pollution and climate history of the lake. Overall a comprehensive reconstruction of anthropogenic and climatic changes to Lake Maggiore for the last five decades is shown.

  2. The Charles F. Prentice Award Lecture 2014: A 50-Year Research Journey: Giants and Great Collaborators.

    PubMed

    Holden, Brien A

    2015-07-01

    This article, an edited version of the 2014 Charles F. Prentice Medal presentation, recounts my 50-year journey in research, from graduation in 1965 to PhD to 2015. The most important lessons I have learned are that great people, "Giants" as I call them, are generous of spirit, creative, insightful, sharing, and caring, and second, that collaboration is really the only way to do what I want to get done. I have been very fortunate to have worked with many outstanding people. As someone said to me at the Prentice Medal presentation, "I don't like you very much but the people you work with are wonderful."My journey started with a PhD investigation into seeing if orthokeratology could control myopia at the City University London in 1966. It then moved to Australia where all aspects of contact lenses were researched to try to make contact lenses safer and more effective by understanding the cornea and anterior eye systems. That journey has now turned to making contact lenses the best they can be to slow the progress of myopia. An extremely high proportion of people who are involved with global eye care initiatives and ambitious projects to develop treatments and interventions for the major vision problems impacting the world are a joy to work with. Evidence-based systems for delivering vision to the more than 600 million people globally that are blind or vision impaired because of uncorrected refractive error have involved amazing people and collaborations. This article pays tribute to the generosity and humanity of my family and the Giants in and outside the field, and many more not so well known, and the people I work with, who have punctuated and greatly enriched this journey and made many of the scientific advances documented here possible. PMID:26002010

  3. Significant warming of continental West Antarctica in the last 50 years

    NASA Astrophysics Data System (ADS)

    Steig, E. J.; Schneider, D. P.

    2008-12-01

    We use statistical climate field reconstruction techniques to determine monthly temperature anomalies for the near-surface of the Antarctic ice sheet since 1957. Two independent data sets are used to provide estimates of the spatial covariance patterns of temperature: automatic weather stations and thermal infrared satellite observations. Quality-controlled data from occupied instrumental weather stations are used to determine the amplitude of changes in those covariance patterns through time. We use a modified principal component analyses technique (Steig et al., in review, Nature) to optimize the combination of spatial and temporal information. Verification statistics obtained from subsets of the data demonstrate the resulting reconstructions represent improvements relative to climatological mean values. We find that significant warming has occurred over most of continental West Antarctica. This is an area much larger than previously reported; most studies have concluded that warming is limited to the Antarctic Peninsula. An updated version of the recent temperature reconstruction of Monaghan et al. (2008, JGR) independently confirms our results. Warming in continental West Antarctica in the last 50 years exceeds 0.1 °C/decade, and is strongest in Spring. A possible explanation is an increase in storms in the Amundsen-Bellinghausen sea, resulting in enhanced warm air fluxes to the continent. Increased storminess in this sector is associated with the positive phase of the zonal wave-3 pattern, which independent observations suggest has increased since the 1970s (Raphael, GRL, 2004). The substantial negative sea ice anomalies in the Amundsen-Bellinghausen sea may also play a role. Our results suggest that changes in the wave-3 pattern dominates over (possibly anthropogenic) changes in the Southern Annular Mode in explaining recent Antarctic temperature variability.

  4. Age at Menarche: 50-Year Socioeconomic Trends Among US-Born Black and White Women

    PubMed Central

    Kiang, Mathew V.; Kosheleva, Anna; Waterman, Pamela D.; Chen, Jarvis T.; Beckfield, Jason

    2015-01-01

    Objectives. We investigated 50-year US trends in age at menarche by socioeconomic position (SEP) and race/ethnicity because data are scant and contradictory. Methods. We analyzed data by income and education for US-born non-Hispanic Black and White women aged 25 to 74 years in the National Health Examination Survey (NHES) I (1959–1962), National Health Examination and Nutrition Surveys (NHANES) I–III (1971–1994), and NHANES 1999–2008. Results. In NHES I, average age at menarche among White women in the 20th (lowest) versus 80th (highest) income percentiles was 0.26 years higher (95% confidence interval [CI] = −0.09, 0.61), but by NHANES 2005–2008 it had reversed and was −0.33 years lower (95% CI = −0.54, −0.11); no socioeconomic gradients occurred among Black women. The proportion with onset at younger than 11 years increased only among women with low SEP, among Blacks and Whites (P for trend < .05), and high rates of change occurred solely among Black women (all SEP strata) and low-income White women who underwent menarche before 1960. Conclusions. Trends in US age at menarche vary by SEP and race/ethnicity in ways that pose challenges to several leading clinical, public health, and social explanations for early age at menarche and that underscore why analyses must jointly include data on race/ethnicity and socioeconomic position. Future research is needed to explain these trends. PMID:25033121

  5. The integration of science and politics to clean up 50 years in the nuclear sandbox

    SciTech Connect

    Lyons, C.E.; Holeman, T.

    1999-07-01

    The Cold War was fought between world superpowers for approximately 40 years from the end of the second World War until the end of the 1980s. During that time, the US government devoted billions of dollars to the development and production of nuclear weapons. Now the Cold War is over and the US is left with numerous nuclear weapons factories, stockpiles of nuclear materials, and mountains of waste to decontaminate and decommission. In the heat of the Cold War, little or no thought was given to how the facilities building bombs would be dismantled. Far too little attention was paid to the potential human health and environmental impact of the weapons production. Now, dozens of communities across the country face the problems this negligence created. In many cases, the location, extent, and characteristics of the waste and contamination are unknown, due to negligence or due to intentional hiding of waste and associated problems. Water supplies are contaminated and threatened; air quality is degraded and threatened; workers and residents risk contamination and health impacts; entire communities risk disaster from potential nuclear catastrophe. The US government, in the form of the US Department of Energy (DOE), now accepts responsibility for creating and cleaning up the mess. But it is the local communities, the home towns of the bomb factories and laboratories, that carry a significant share of the burden of inventing the science and politics required to clean up 50 years in the nuclear sandbox. The purpose of this paper is to evaluate the role of the local community in addressing the cleanup of the US nuclear weapons complex. Local governments do not own nor are responsible for the environmental aftermath, but remain the perpetual neighbor to the facility, the hometown of workers, and long-term caretaker of the off-site impacts of the on-site contamination and health risks.

  6. Sequential Imaging of Earth by Astronauts: 50 Years of Global Change

    NASA Technical Reports Server (NTRS)

    Evans, Cynthia A.

    2009-01-01

    For nearly 50 years, astronauts have collected sequential imagery of the Earth. In fact, the collection of astronaut photography comprises one of the earliest sets of data (1961 to present) available to scientists to study the regional context of the Earth s surface and how it changes. While today s availability of global high resolution satellite imagery enables anyone with an internet connection to examine specific features on the Earth s surface with a regional context, historical satellite imagery adds another dimension (time) that provides researchers and students insight about the features and processes of a region. For example, one of the geographic areas with the longest length of record contained within the astronaut photography database is the lower Nile River. The database contains images that document the flooding of Lake Nasser (an analog to today s flooding behind China s Three Gorges Dam), the changing levels of Lake Nasser s water with multiyear cycles of flood and drought, the recent flooding and drying of the Toshka Lakes, as well as urban growth, changes in agriculture and coastal subsidence. The imagery database allows investigations using different time scales (hours to decades) and spatial scales (resolutions and fields of view) as variables. To continue the imagery collection, the astronauts on the International Space Station are trained to understand basic the Earth Sciences and look for and photograph major events such as tropical storms, landslides, and volcanic eruptions, and document landscapes undergoing change (e.g., coastal systems, cities, changing forest cover). We present examples of selected sequences of astronaut imagery that illustrate the interdependence of geological processes, climate cycles, human geography and development, and prompt additional questions about the underlying elements of change.

  7. Neighbourhood socioeconomic status and coronary heart disease in individuals between 40 and 50 years

    PubMed Central

    Carlsson, Axel C; Li, Xinjun; Holzmann, Martin J; Wändell, Per; Gasevic, Danijela; Sundquist, Jan; Sundquist, Kristina

    2016-01-01

    Objective The incidence of myocardial infarction (MI) has decreased in general but not among younger middle-aged adults. We performed a cohort study of the association between neighbourhood socioeconomic status (SES) at the age of 40 and risk of MI before the age of 50 years. Methods All individuals in Sweden were included in the year of their 40th birthday, if it occurred between 1998 and 2010. National registers were used to categorise neighbourhood SES into high, middle and low, and to retrieve information on incident MI and coronary heart disease (CHD). Cox regression models, adjusted for marital status, education level, immigrant status and region of residence, provided an estimate of the HRs and 95% CIs for MI or CHD. Results Out of 587 933 men and 563 719 women, incident MI occurred in 2877 (0.48%) men and 932 (0.17%) women; and CHD occurred in 4400 (0.74%) men and 1756 (0.31%) women during a mean follow-up of 5.5 years. Using individuals living in middle-SES neighbourhoods as referents, living in high-SES neighbourhoods was associated with lower risk of MI in both sexes (HR (95% CI): men: 0.72 (0.64 to 0.82), women: 0.66 (0.53 to 0.81)); living in low-SES neighbourhoods was associated with a higher risk of MI (HR (95% CI): men: 1.31 (1.20 to 1.44), women: 1.28 (1.08 to 1.50)). Similar risk estimates for CHD were found. Conclusions The results of our study suggest an increased risk of MI and CHD among residents from low-SES neighbourhoods and a lower risk in those from high-SES neighbourhoods compared with residents in middle-SES neighbourhoods. PMID:26864672

  8. The changes of glaciers on northern Baikal ridges over 50 years using in-situ and remotely sensed observations

    NASA Astrophysics Data System (ADS)

    Ivanov, Egor; Alexander, Kitov

    2013-04-01

    All the glaciers lying over the Baikalsky and Barguzinsky ridges of Northern Baikal are small. They are located in hard-to-reach regions both for In-situ such and for remotely sensed observations. A researcher can reach glaciers only by using special alpine equipment. The deep ruggedness of hollows and the being of glaciers in the shade over a period of significant time prevent from remotely sensed observations. The Glaciers of Baikalsky ridge are not registered in the catalogue of the Eurasia glaciers since there are no data about the glaciers in the catalogue of the glaciers of USSR. In result of our expedition works and the analyzing of satellite photograph it was determined that the largest cirque glacier- Cherskogo sufficiently stable. Its retreat has been insignificantly in over 50 years - from 0.446 to 0.407 sq. km, id est on 8,7 %. The glaciers of Barguzinsky ridge are very poorly explored. IG SB RAS in 2011 year for the first time completed the expedition with the object of inventory of these ridge glaciers. This region is extremely difficult to approach. The space survey of ultrahigh resolution for the study area (0.5 m) was ordered before the start of the expedition. Also the accessible archive data of Landsat resolution by 15-30 meters have been received. The comparison of cartographical, distance and expedition data show essential retreat of most of glaciers and its degradation from cirque to slope glaciers. Discovered snow-glacial formations can be divided on 3 main groups: 1 -real glaciers; 2 - slope pendent glacier remains; 3 - permanent snow patches. The region is interesting because there practically are all the forms of little glaciations. In addition it can be observed not only glacier's degradation but their origins too. In the favorable year conditions the snow patches are increased with occupying of the basic of cirque bed and form the ice core and continue the formation of the cirque. The second group of glaciers has actually been reserved

  9. Building on 50 Years of Systems Engineering Experience for a New Era of Space Exploration

    NASA Technical Reports Server (NTRS)

    Dumbacher, Daniel L.; Lyles, Garry M.; McConnaughey, Paul K.

    2008-01-01

    Over the past 50 years, the National Aeronautics and Space Administration (NASA) has delivered space transportation solutions for America's complex missions, ranging from scientific payloads that expand knowledge, such as the Hubble Space Telescope, to astronauts and lunar rovers destined for voyages to the Moon. Currently, the venerable Space Shuttle, which has been in service since 1981, provides the United States (US) capability for both crew and heavy cargo to low-Earth orbit to construct the International Space Station, before the Shuttle is retired in 2010. In the next decade, NASA will replace this system with a duo of launch vehicles: the Ares I crew launch vehicle and the Ares V cargo launch vehicle. The goals for this new system include increased safety and reliability coupled with lower operations costs that promote sustainable space exploration for decades to come. The Ares I will loft the Orion crew exploration vehicle, while the heavy-lift Ares V will carry the Altair lunar lander, as well as the equipment and supplies needed to construct a lunar outpost for a new generation of human and robotic space pioneers. NASA's Marshall Space Flight Center manages the Shuttle's propulsion elements and is managing the design and development of the Ares rockets, along with a host of other engineering assignments in the field of scientific space exploration. Specifically, the Marshall Center's Engineering Directorate houses the skilled workforce and unique facilities needed to build capable systems upon the foundation laid by the Mercury, Gemini, Apollo, and Shuttle programs. This paper will provide details of the in-house systems engineering and vehicle integration work now being performed for the Ares I and planned for the Ares V. It will give an overview of the Ares I system-level testing activities, such as the ground vibration testing that will be conducted in the Marshall Center's Dynamic Test Stand to verify the integrated vehicle stack's structural

  10. Evidence for water cycle changes during past 50 years in Tibetan Plateau: Review and synthesis

    NASA Astrophysics Data System (ADS)

    Zhang, Y.

    2010-12-01

    The Tibetan Plateau, the largest geomorphologic unit on the Eurasian continent, and highest plateau in the world, exhibits “Asian water tower” A large amount of water is stored in the world’s highest and largest plateau, the Tibetan Plateau, in the forms of glaciers, snowpacks, lakes, and rivers. It is vital to understand whether the supply to these water resources has been experiencing any changes during recent global warming. Climate warming on the plateau in past decades has been suggested by meteorological observation and ice core records. The average annual and winter temperatures on the plateau rose about 0.16o and 0.32 o C per decade, respectively, from 1955 to 1996. The climatic warming trend seems more evident on the plateau than globally during the past 50 years. In response to the warming, one of the more important questions in hydrology is: if the climate warms in the future, will there be an intensification of the water cycle and, if so, what are evidence have been cached by current framework? There is considerable interest in this question because an intensification of the water cycle may lead to changes in water-resource availability, an increase in the frequency and intensity of droughts, and an amplification of warming through the water vapor feedback. Empirical evidence for ongoing intensification of the water cycle would provide additional support for the theoretical framework that links intensification with warming. There are 75 metrological observatories and 16 hydrological stations located on the Tibetan Plateau, comprising the Tibetan Autonomous Region, Qinghai Province, and parts of Sichuan and Gansu provinces, widely ranging from southern to northern part of the plateau. These data can be approximately regarded as natural flow data because the human water use is very small in quantity and can thus be ignored in these gauged catchments, These data were widely used in estimation of variation of runoff and evaporation. Various satellite

  11. Relationship between microbial diversity and chemical contamination along a 50-year-old sediment core

    NASA Astrophysics Data System (ADS)

    Berthe, T.; Petit, F.; Boust, D.; Lesueur, P.; Roose-Amsaleg, C.; Cécillon, S.; Kaci-Benaicha, A.

    2013-12-01

    The purpose of this study was to evaluate the potential use of sediment microbial diversity (community structure) as an indicator of the impact of anthropogenic activities within an estuarine ecosystem. The diversity of microbial communities was investigated along a 5-m-long sediment core collected in an anthropized European estuary (Seine, France), giving an evolution of trace metal, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) concentrations over the last 50 years. An increase of trace metal and PCB concentrations are observed with depth, with an enrichment of these contaminants in the 1970s. The concentration profiles of light, intermediate and heavy PAHs showed distinct peaks, but the highest total PAH concentration was also detected in the sediment from the 1970s. We first investigated the bacterial community resistant to cobalt, zinc and cadmium by analyzing the diversity of the czcA gene encoding an RND efflux pump (Heavy Metal Efflux-RND) in 5-year and 33-year-old sediment samples displaying contrasted concentrations in these trace metals. The diversity of the czcA gene was reduced in the 33-year-old and more contaminated sediments suggesting a selection of resistant bacterial species. A molecular fingerprinting method (DGGE) was used to study the evolution of total microbial (Bacteria and Archaea) community structures for samples selected along the sediment core. A correlation is observed between the bacterial community structures, the sediment age, the trace metal and PAH concentrations. The metabolically active and total microbial communities were further characterized by a microarray approach (Phylochips) in sediment samples selected according to the DGGE results. Bacterial diversity was found dominated by Proteobacteria, Actinobacteria, and Firmicutes in all analyzed samples. Diversity of phylotypes corresponds to changes in PAH and trace metal concentrations in sediment, suggesting that chemical contaminants have

  12. The Astrophysical r-Process 50 Years after B{sup 2}FH

    SciTech Connect

    Kratz, K.-L.; Pfeiffer, B.; Farouqi, K.; Mashonkina, L. I.

    2008-01-24

    Since the historical papers by Burbidge et al. and Cameron 50 years ago, it is generally accepted that half of the chemical elements above Fe are formed in explosive stellar scenarios by a rapid neutron-capture process (the classical ''r-process''). Already from their essential ideas, it became clear that a correct modelling of this nucleosynthesis process requires both, the knowledge of various nuclear properties very far from stability and a detailed description of the astrophysical environments. However, it took about three decades, until in 1986 the first experimental nuclear-physics data on the neutron-magic r-isotopes {sup 80}Zn and {sup 130}Cd could be obtained, which act as key ''waiting points'' in the respective A{approx_equal}80 and 130 peaks of the Solar-System (SS) r-abundances (N{sub r,{center_dot}}). Since then, using steadily improved nuclear data, we have optimized our r-process calculations to reproduce the present observables of the isotopic N{sub r,{center_dot}} ''residuals'', as well as the more recent elemental abundances in ultra-metal-poor, r-process-enriched halo stars. Concerning the latter observations, we support the basic idea about two different types of r-processes. Based on our many years' experience with the site-independent ''waiting-point approach'', we recently have extended our studies to fully dynamical network calculations for the most likely astrophysical r-process scenario, i.e. the high-entropy wind (HEW) of core-collapse type II supernovae (SN II). Again, an excellent reproduction of all observables for the ''main'' r-process has been achieved. However, a major difference is the nucleosynthesis origin of the lighter heavy elements in the 29{<=}Z{<=}45 mass region. Here, the HEW model predicts-instead of a ''weak'' neutron-capture r-process component-a primary rapid charged-particle process. This may explain the recent observations of a non-correlation of these elements with the heavier ''main'' r-process elements.

  13. EDITORIAL: International Conference on Finite Fermionic Systems: Nilsson Model 50 Years

    NASA Astrophysics Data System (ADS)

    2006-06-01

    In 1955 Sven Gösta Nilsson published the paper `Binding States of Individual Nucleons in Strongly Deformed Nuclei'. This eminent work has been crucial for the understanding of the structure of deformed atomic nuclei. Moreover, the so-called Nilsson model has been widely used for the description of other types of finite systems of fermions such as quantum dots and cold fermionic atoms. During one week in June 2005 we celebrated in Lund the 50th anniversary of the Nilsson model with the International Conference on Finite Fermionic Systems - Nilsson Model 50 Years. With the historical view in mind, the conference focused on present and future problems in nuclear structure physics as well as on the physics of other types of finite Fermi systems. As a background to the recent developments Nobel Laureate Ben Mottelson presented a recollection of early applications and achievements of the Nilsson model in the first talk of the conference, including a personal view of Sven Gösta Nilsson. We are particularly pleased that this contribution could be included in these proceedings. The scientific programme was structured according to the following subjects: Shell structure and deformations The heaviest elements and beyond Nuclei far from stability Pairing correlations Nuclear spectroscopy: large deformations Nuclear spectroscopy: rotational states Order and chaos Cold fermionic atoms Quantum dots Many new and interesting results were presented in the 15 invited talks, 30 oral contributions, and in the 33 papers of the poster sessions. The present volume of Physica Scripta contains most of the talks, as well as the short contributions of the posters. We thank the speakers and all participants who actively contributed to give this memorable conference a very high scientific level in the presented contributions, as well as in numerous discussions inside and outside the sessions. We also thank the international advisory committee for their invaluable work in helping us setting up

  14. Perceived weight discrimination in England: a population-based study of adults aged ⩾50 years

    PubMed Central

    Jackson, S E; Steptoe, A; Beeken, R J; Croker, H; Wardle, J

    2015-01-01

    Background: Despite a wealth of experimental studies on weight bias, little is known about weight discrimination at the population level. This study examined the prevalence and socio-demographic correlates of perceived weight discrimination in a large population-based sample of older adults. Methods: Data were from 5307 adults in the English Longitudinal Study of Ageing; a population-based cohort of men and women aged ⩾50 years. Weight discrimination was reported for five domains (less respect/courtesy; treated as less clever; poorer treatment in medical settings; poorer service in restaurants/stores; threatened/harassed) at wave 5 (2010–2011). Height and weight were measured at wave 4 (2008–2009). We used logistic regression to test the odds of weight discrimination in relation to weight status, age, sex, wealth, education and marital status. Results: Perceived weight discrimination in any domain was reported by 4.6% of participants, ranging from 0.8% in the normal-weight participants through 0.9, 6.7, 24.2 and 35.1% in individuals who were overweight or met criteria for class I, II and III obesity. Overall, and in each situation, odds of perceived weight discrimination were higher in younger and less wealthy individuals. There was no interaction between weight status and any socio-demographic variable. Relative to normal-weight participants, odds ratios for any perceived weight discrimination were 1.13 (95% confidence interval 0.53–2.40) in those who were overweight, 8.86 (4.65–16.88) in those with class I obesity, 35.06 (18.30–67.16) in class II obese and 56.43 (27.72–114.87) in class III obese. Conclusions: Our results indicate that rates of perceived weight discrimination are comparatively low in individuals who are overweight or have class I obesity, but for those with class II/III obesity, >10% had experienced discrimination in each domain, and >20% had been treated with less respect or courtesy. These findings have implications for public

  15. Effects of thinning intensities on transpiration and productivity of 50-year-old Pinus koraeinsis stands

    NASA Astrophysics Data System (ADS)

    Park, Juhan; Kim, Taekyu; Moon, Minkyu; Cho, Sungsik; Ryu, Daun; Kim, Hyun Seok

    2015-04-01

    This study investigated the effects of thinning intensities on stand transpiration and productivity of 50-year-old Korean pine forests for two years. Forest thinning, which removes some fraction of trees from stand, is widely conducted for reducing competition between remaining trees, improving tree productivity, reducing the risk of natural fire, and thus maintaining healthy forest. Forest thinning alters the microclimatic conditions such as radiation distribution within canopy, vapor pressure deficit, and amount of available soil water. These changes influence on the tree water use, and related productivity. Thinning was conducted on March, 2012 with two intensities (Control, Light-thinning (20%), and Heavy-thinning (40% of tree density)). Transpiration was estimated from sap flux density, which was measured with Granier-type thermal dissipation sensors. Tree diameter growth was measured with dendrometer, and converted to tree productivity using allometric equations developed specifically in our study sites. The climatic conditions showed little differences between two years. During the first growing season after thinning, stand transpiration was ca. 20% and 42% lower on light-thinning and heavy-thinning stand, respectively, even though sap flux density were higher in thinned stand. The difference in stand transpiration among treatments showed seasonal trends, so it was larger on summer when soil moisture was abundant due to monsoon, but was diminished on spring and autumn when soil moisture was limited. Tree-level productivity increased ca. 8% and 21% on light-thinning and heavy thinning stand, respectively. However, stand net primary production was ca. 20% lower on light-thinning stand, and ca. 31% on heavy-thinning stand. As a result, water use efficiency increased only in heavy-thinning stand. During the second growing season after thinning, stand transpiration was ca. 19% lower on light-thinning stand, and ca. 37% lower on heavy-thinning stand. The reduction

  16. Effects of thinning intensities on transpiration and productivity of 50-year-old Pinus koraeinsis stands

    NASA Astrophysics Data System (ADS)

    Park, J.; Kim, T.; Cho, S.; Ryu, D.; Moon, M.; Kim, H. S.

    2015-12-01

    This study investigated the effects of thinning intensities on stand transpiration and productivity of 50-year-old Korean pine forests for three years. Forest thinning, which remove some fraction of trees from stand, alters the microclimatic conditions such as radiation distribution within canopy, vapor pressure deficit, and amount of available soil water. These changes influence on the tree water use, and related tree growth. Thinning was conducted on March, 2012 with two intensities (Control, Light-thinning, and Heavy-thinning). Transpiration was estimated from sap flux density, which was measured with Granier-type thermal dissipation sensors. Tree diameter growth was measured with dendrometer, and converted to tree productivity using allometric equations developed specifically in our study sites.The climatic conditions showed remarkable differences among three years. In 2012, total precipitation was highest but spring was dry. 2013 was normal year with frequent rain events. In contrast, 2014 was hot and extremely dry. Stand transpiration was initially decreased ca. 20% and 42% on light-thinning and heavy-thinning stand, respectively. In second year, it gradually recovered in both thinning intensities, and was 19% and 37% lower on light-thinning and heavy-thinning stand, respectively. However, the recovery trends were different between two thinning intensities. Transpiration of heavy-thinning stand was recovered slowly than that of light thinning stand. In 2014, heavy-thinning stand transpired ca. 5% more than control plot in early growing season, but severe drought had negative effects that caused reduction of stand transpiration in thinned stand on late growing season. The tree-level productivity was increased initially ca. 24% and 28% on light-thinning and heavy-thinning stand, respectively. During the following growing seasons, this thinning-induced enhancement of productivity was diminished in light-thinning stand (21% in 2013 and 20% in 2014), but was

  17. Incidence, Morbidity and Mortality in Patients Older than 50 Years with Second Hip Fracture in a Jeju Cohort Study

    PubMed Central

    Park, Yong-Geun; Jang, Sunmee

    2014-01-01

    Purpose Although the incidence of a second hip fracture is relatively well described, mortality and morbidity after a second hip fracture are seldom evaluated. The purpose of this study was to determine the incidence, morbidity, and mid-term mortality of a second hip fracture and evaluate the cause of death after a second hip fracture. Materials and Methods Information on patients older than 50 years, who sustained a subsequent hip fracture, were obtained from the records of eight Jeju Island hospitals between 2002 and 2011 to calculate the incidence, morbidity, and mortality of hip fractures in this age group. All patients were followed a minimum of 2 years. A systemic search for death certificates at the National Statistical Office was conducted for patients who were lost to follow-up. Results Of 2,055 hip fractures (419 men and 1,636 women), 98 were second hip fractures (13 men and 85 women) during the study period. The mean ages of the patients at the time of the first and second fractures were 78.8 and 80.8 years, respectively. The incidence of a subsequent hip fracture among the first hip fracture was 4.8%. Mean mortality rates at 6 months, 1 year, 2 years, and 5 years were 10.5%, 15.2%, 23.5%, and 42.0% respectively. Cumulative mortality after the second hip fracture at the 5 years follow-up was 41.8%. Conclusion Our results demonstrate that a secondary fracture prevention program is necessary to prevent second hip fractures in elderly patients.

  18. Long Distance Bicycle Riding Causes Prostate-Specific Antigen to Increase in Men Aged 50 Years and Over

    PubMed Central

    Mejak, Sandra L.; Bayliss, Julianne; Hanks, Shayne D.

    2013-01-01

    Objectives To investigate whether bicycle riding alters total prostate-specific antigen (tPSA) serum concentrations in healthy older men. Methods 129 male participants, ranging in age from 50 to 71 years (mean 55 years), rode in a recreational group bicycle ride of between 55 and 160 kilometers. Blood samples for tPSA analysis were drawn within 60 minutes before starting, and within 5 minutes after completing the ride. The pre-cycling and post-cycling tPSA values were log transformed for normality and compared using paired t-tests. Linear regression was used to assess the relationship between changes in tPSA with age and distance cycled. Results Bicycle riding caused tPSA to increase by an average of 9.5% (95% CI = 6.1–12.9; p<0.001) or 0.23 ng/ml. The number of participants with an elevated tPSA (using the standard PSA normal range cut-off of 4.0 ng/ml) increased from two pre-cycle to six post-cycle (or from five to eight when using age-based normal ranges). Univariate linear regression analysis revealed that the change in tPSA was positively correlated with age and the distance cycled. Conclusions Cycling causes an average 9.5% increase in tPSA, in healthy male cyclists ≥50 years old, when measured within 5 minutes post cycling. We considered the increase clinically significant as the number of participants with an elevated PSA, according to established cut-offs, increased post-ride. Based on the research published to date, the authors suggest a 24–48 hour period of abstinence from cycling and ejaculation before a PSA test, to avoid spurious results. PMID:23418500

  19. Predicting fire activity in the US over the next 50 years using new IPCC climate projections

    NASA Astrophysics Data System (ADS)

    Wang, D.; Morton, D. C.; Collatz, G. J.

    2012-12-01

    Fire is an integral part of the Earth system with both direct and indirect effects on terrestrial ecosystems, the atmosphere, and human societies (Bowman et al. 2009). Climate conditions regulate fire activities through a variety of ways, e.g., influencing the conditions for ignition and fire spread, changing vegetation growth and decay and thus the accumulation of fuels for combustion (Arora and Boer 2005). Our recent study disclosed the burned area (BA) in US is strongly correlated with potential evaporation (PE), a measurement of climatic dryness derived from National Centers for Environmental Prediction (NCEP) North American Regional Reanalysis (NARR) climate data (Morton et al. 2012). The correlation varies spatially and temporally. With regard to fire of peak fire seasons, Northwestern US, Great Plains and Alaska have the strongest BA/PE relationship. Using the recently released the Global Fire Emissions Database (GFED) Version 3 (van der Werf et al. 2010), we showed increasing BA in the last decade in most of NCA regions. Longer time series of Monitoring Trends in Burn Severity (MTBS) (Eidenshink et al. 2007) data showed the increasing trends occurred in all NCA regions from 1984 to 2010. This relationship between BA and PE provides us the basis to predict the future fire activities in the projected climate conditions. In this study, we build spatially explicit predictors using the historic PE/BA relationship. PE from 2011 to 2060 is calculated from the Coupled Model Intercomparison Project Phase 5 (CMIP5) data and the historic PE/BA relationship is then used to estimate BA. This study examines the spatial pattern and temporal dynamics of the future US fires driven by new climate predictions for the next 50 years. Reference: Arora, V.K., & Boer, G.J. (2005). Fire as an interactive component of dynamic vegetation models. Journal of Geophysical Research-Biogeosciences, 110 Bowman, D.M.J.S., Balch, J.K., Artaxo, P., Bond, W.J., Carlson, J.M., Cochrane, M.A., D

  20. PREFACE: 50 years in science: Alejandro Szanto de Toledo (2045-2015)

    NASA Astrophysics Data System (ADS)

    2015-07-01

    During the XXXVII RTFNB 2014, we had the pleasure to organize a tribute to Professor Alejandro Szanto de Toledo to commemorate his 50 years of dedication to nuclear physics. Named ''Alexfest'', it gathered friends and very prominent physicists from around the world that came to Brazil specially to render a tribute to Alex, as many friends and colleagues called him. During the whole afternoon, the invited speakers presented some of the physics topics and important contributions that Alex gave to the field of nuclear physics during his five decades of intense work. Alex is the responsible for several landmarks in the Brazilian nuclear science, especially in the Institute of Physics of the University of Sao Paulo (IFUSP), where he spent almost his entire career. He started his professional life in the IFUSP Van de Graaf Laboratory, under Oscar Sala's supervision as an undergraduate student. His talent allowed him to give significant contributions to the machine operation since the beginning of his internship in the laboratory. He soon became the responsible for the development, construction and implementation of an ion source for the new Pelletron accelerator, project coordinated by Oscar Sala as well. This was a huge responsibility for a young master degree student. His PhD thesis was about nuclear fusion, a topic that he mastered during his career. His international reputation allowed him to become a visiting researcher at several laboratories in the US, France, Japan, Russia and Germany. Not satisfied with the challenges that his career was imposing to him, Alex pioneered the creation of a high-energy nuclear physics group in Brazil, becoming member of the STAR (Solenoidal Tracker At Rhic) collaboration in 1995, one of the two major experiments of the RHIC accelerator (Relativistic heavy Ion Collider), located in the Brookhaven National Laboratory, USA. Later on, in 2006, he also led his group to become part of the LHC (Large Hadron Collider) experiment ALICE (A

  1. [Gregorio Marañón, a pioneer of endocrinology, 50 years after his death].

    PubMed

    Zarate, Arturo

    2011-01-01

    Gregorio Maranon born and dead in Madrid (1887-1960), was a Spanish physician, scientist, historian, philosopher, humanist, and writer, considered one of the most brilliant Spanish intellectuals of the 20th century. He was also a Republican and fought the Primo de Rivera dictatorship, though later expressed his disagreement with communism. Maranon participated closely with the process of exile of Alfonso XIII. From a very early age he learned several foreign languages and was an avid reader, hence he became in contact with the intellectual circles of the time and cultivated a close friendship with Perez Galdos, Menendez-Pelayo, Ortega y Gasset, Pio Baroja, Unamuno, Lerroux among several outstanding and eminent figures of the famous Generation of 14. In Medical School he had great teachers such as Santiago Ramon y Cajal, and later he specialized in endocrinology and became professor of the specialty in the Complutense University in Madrid, moreover he founded the Institute of Medical Pathology and the Department of Experimental Endocrinology, henceforth he contributed to establish the relationship between endocrinology and psychology. At the beginning of the instauration of the Republic, Maranon became a member of the constituent assembly and the parliament, but soon became disillusioned of communism and left Spain before the initiation of the Civil War, remaining in France until 1942 when he returned to Spain to reestablish his private practice, and soon the medical teaching at the hospital which now bears his name. Late work about history, poetry was elaborated at his Toledo Cigarral de Menores. PMID:21527976

  2. 26 CFR 31.6011(a)-6 - Final returns.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...—(i) Form CT-1. An employer required to make returns on Form CT-1 who in any return period ceases to pay taxable compensation shall make the return on Form CT-1 for such period as a final return. Such... ceased to pay taxable compensation shall continue to file returns on Form CT-1. (ii) Form CT-2....

  3. Variation of the Earth tide-seismicity compliance parameter the last 50 years for the seismic area of Evoikos, Greece

    NASA Astrophysics Data System (ADS)

    Contadakis, Michael E.; Arabelos, Demetrious N.; Vergos, George; Spatalas, Spyrous

    2015-04-01

    The results of the analysis of the last 50 years earthquakes series in seismic active areas of Greece, i.e. the areas (a) of the Mygdonian Basin(Contadakis et al. 2007), (b) of the Ionian Islands (Contadakis et al. 2012 ) and (c) of the Hellenic Arc (Vergos et al. 2012 ), indicate that the monthly variation of the frequencies of earthquake occurrence is in accordance with the period of the tidal lunar monthly and semi-monthly (Mm and Mf) variations. The same happens with the corresponding daily variations of the frequencies of earthquake occurrence with the diurnal luni-solar (K1, O1) and semidiurnal lunar (M2) and solar (S2) tidal variations. In addition the confidence level for the identification of such period accordance between earthquakes occurrence frequency and tidal periods varies with seismic activity, i.e. the higher confidence level corresponds to periods with stronger seismic activity. These results are in favor of a tidal triggering process on earthquakes when the stress in the focal area is near the critical level. Based on these results, we consider the confidence level of earthquake frequency of occurrence - tidal period accordance, p, as an index of tectonic stress criticality for earthquake occurrence. A test on posterior of this idea, (i.e. the value of the confidence level index, p, indicate the fault matureness) in the case of the recent seismic activity at Fthiotida, was positive (Contadakis et al 2014). In this paper we present the results of a second test by the occasion of the recent seismic activity of Central Evoikos. The results also are positive. We suggest that this compliance parameter may be used as an additional element for the seismic risk assessment. References Cadicheanu, N., van Ruymbeke, M and Zhu P.,2007:Tidal triggering evidence of intermediate depth earthquakes in Vrancea zone(Romania), NHESS 7,733-740. Contadakis, M. E., Arabelos, D. N., Spatalas, S., 2009, Evidence for tidal triggering on the shallow earthquakes of the

  4. Tatanka Returns.

    ERIC Educational Resources Information Center

    Simonelli, Richard

    1993-01-01

    Describes efforts of the InterTribal Bison Cooperative (Rapid City, SD) to reintroduce the buffalo for cultural purposes to American Indian reservations. Explains how the buffalo's return is contributing to community wellness. Discusses career opportunities for both Native and non-Native people in buffalo management. (LP)

  5. Simple Cognitive and Behavioural Changes Resulting from Improved Physical Fitness in Persons over 50 Years of Age.

    ERIC Educational Resources Information Center

    Stacey, C.; And Others

    1985-01-01

    Evaluates the effects of exercise on simple cognitive performance and on psychological well-being in persons over 50 years of age. It also assesses the relationship between a set of subject variables and dropout from fitness programs. Results suggest that the beneficial effects of exercise may extend to cognitive and personality processes.…

  6. Implementing principles of the integrated control concept 50 years later – current challenges in IPM for arthropod pests

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The 1959 publication of the article ‘The Integrated Control Concept’ by Stern and colleagues established a new philosophical framework for pest management that eventually provided a foundation for IPM to develop. Considered within the context of pest control approaches 50 years ago, the integrated ...

  7. Disease Burden Due to Herpes Zoster among Population Aged ≥50 Years Old in China: A Community Based Retrospective Survey

    PubMed Central

    Yin, Dapeng; Liu, Yanmin; Huang, Zhuoying; Xu, Jianfang; Ma, Yujie; Tu, Qiufeng; Li, Qi; Wang, Huaqing

    2016-01-01

    Objective To understand the disease burden due to Herpes Zoster (HZ) among people aged ≥50 years old in China and provide baseline data for future similar studies, and provide evidence for development of herpes zoster vaccination strategy. Methods Retrospective cohort study was conducted in 4 townships and one community. A questionnaire was used to collect information on incidence and cost of HZ among people aged ≥ 50 years old. Results The cumulative incidence rate was 22.6/1,000 among people aged ≥ 50 years old. The average annual incidence rate of HZ was 3.43/1,000 among people aged ≥ 50 years old in 2010–2012. Cumulative incidence and average annual incidence rate increased with age: the cumulative incidence of HZ among people aged ≥ 80 years old was 3.34 times of that among 50- years old (52.3/1000vs15.7/1,000); average annual incidence rate rises from 2.66/1,000 among 50- years old to 8.55/1,000 among 80- year old. Cumulative incidence and average annual incidence rate for females were higher than that for males (cumulative incidence, 26.5/1000vs18.7/1,000; annual incidence rate, 3.95/1000vs2.89/1,000). Cumulative incidence and average annual incidence rate in urban were higher than in rural (cumulative incidence, 39.5/1000vs 17.2/1,000; annual incidence rate, 7.65/1000vs2.06/1,000). The hospitalization rate of HZ was 4.53%. And with the increase of age, the rate has an increasing trend. HZ costs 945,709.5 RMB in total, corresponding to 840.6 RMB per patient with a median cost of 385 RMB (interquartile range 171.7–795.6). Factors associated with cost included the first onset year, area, whether hospitalized and whether sequelae left. Conclusion Incidence rate, complications, hospitalization rate and average cost of HZ increase with age. We recommend that the HZ vaccinations should target people aged ≥50 years old if Zoster vaccine is licensed in China. PMID:27055179

  8. A post audit and inverse modeling in reactive transport: 50 years of artificial recharge in the Amsterdam Water Supply Dunes

    NASA Astrophysics Data System (ADS)

    Karlsen, R. H.; Smits, F. J. C.; Stuyfzand, P. J.; Olsthoorn, T. N.; van Breukelen, B. M.

    2012-08-01

    SummaryThis article describes the post audit and inverse modeling of a 1-D forward reactive transport model. The model simulates the changes in water quality following artificial recharge of pre-treated water from the river Rhine in the Amsterdam Water Supply Dunes using the PHREEQC-2 numerical code. One observation dataset is used for model calibration, and another dataset for validation of model predictions. The total simulation time of the model is 50 years, from 1957 to 2007, with recharge composition varying on a monthly basis and the post audit is performed 26 years after the former model simulation period. The post audit revealed that the original model could reasonably predict conservative transport and kinetic redox reactions (oxygen and nitrate reduction coupled to the oxidation of soil organic carbon), but showed discrepancies in the simulation of cation exchange. Conceptualizations of the former model were inadequate to accurately simulate water quality changes controlled by cation exchange, especially concerning the breakthrough of potassium and magnesium fronts. Changes in conceptualization and model design, including the addition of five flow paths, to a total of six, and the use of parameter estimation software (PEST), resulted in a better model to measurement fit and system representation. No unique parameter set could be found for the model, primarily due to high parameter correlations, and an assessment of the predictive error was made using a calibration constrained Monte-Carlo method, and evaluated against field observations. The predictive error was found to be low for Na+ and Ca2+, except for greater travel times, while the K+ and Mg2+ error was restricted to the exchange fronts at some of the flow paths. Optimized cation exchange coefficients were relatively high, especially for potassium, but still within the observed range in literature. The exchange coefficient for potassium agrees with strong fixation on illite, a main clay mineral in

  9. Evidence of bottom-up control of marine productivity in the Mediterranean Sea during the last 50 years

    NASA Astrophysics Data System (ADS)

    Macías, Diego; Garcia-Gorriz, Elisa; Piroddi, Chiara; Stips, Adolf

    2014-05-01

    The temporal dynamics of biogeochemical variables derived from a coupled 3D hydrodynamic-biogeochemical model of the entire Mediterranean Sea is evaluated during the last 50 years (1960 - 2010). Realistic atmospheric forcing and river discharge are used to force the dynamics of the coupled model system. The time evolutions of primary and secondary productions in the entire basin are assessed against available independent data on fisheries yields and catches per unit effort for the same time period. Concordant patterns are found in the time-series of all biological variables (from the model and from fisheries statistics), with low values at the beginning of the series, a later increase with maximum values reached at the end of the 1990's and a posterior stabilization or a small decline. Spectral analysis of the annual biological time-series reveals coincident low-frequency signals in all of them; the first, more energetic signal, peaks at 2000 while the second one (less energetic) presents maximum values at around 1982. Almost identical low-frequency signals are found in the nutrient loads of the main rivers of the basin and in the integrated (0-100 meters) mean nutrient concentrations in the marine ecosystem. Nitrate concentration shows an increasing trend up to 1998 with a later stabilization or a slight decline to present day values. This nitrate evolution seems to be driving the first low-frequency signal found in the biological time series. Phosphate, on the other hand, shows maximum concentrations around 1982 and a posterior sharp decline. This nutrient seems to be responsible for the second low-frequency signal observed in the biological time-series. Our analysis shows that the control of marine productivity (from plankton to fish) in the Mediterranean basin seem to be principally mediated through bottom-up processes that could be traced back to the characteristics of riverine discharges. Other types of control could not be excluded from our analysis (e

  10. A Statistical Analysis of 50 Years of Daily Solar Wind Velocity Data

    NASA Astrophysics Data System (ADS)

    LI, K. J.; ZHANNG, J.; FENG, W.

    2016-05-01

    Daily mean value of solar wind velocity measured by various spacecraft near the Earth’s orbit from 1963 November 27 to 2013 December 31 given by OMNIWeb is utilized to investigate its characteristics through statistical analyses. The percent probability distribution of solar wind velocity can be described well by the Γ distribution function with the most probable velocity to be 373 {km} {{{s}}}-1. It is found that solar wind could be statistically classified into three groups: (1) the low-velocity wind, v\\lt 450 {km} {{{s}}}-1, which positively responds to, and in the cycle phase lags, the solar activity cycle; (2) the high-velocity wind, 450≤slant v\\lt 725 {km} {{{s}}}-1, which negatively responds to, and in the cycle phase leads, the solar activity cycle, but in a short timescale (one-rotation-period) lags the solar activity cycle; and (3) the extreme-high-velocity wind, v≥slant 725 {km} {{{s}}}-1, which positively responds to, and in cycle phase leads, the solar activity cycle. A period of about 27 days is determined for solar wind in the first two groups, so that solar wind in the groups is modulated by the solar rotation and related with solar long-life magnetic structures. Solar wind of extreme high velocity appears mainly at the descending phases of the solar cycles.

  11. Lucid dreaming incidence: A quality effects meta-analysis of 50years of research.

    PubMed

    Saunders, David T; Roe, Chris A; Smith, Graham; Clegg, Helen

    2016-07-01

    We report a quality effects meta-analysis on studies from the period 1966-2016 measuring either (a) lucid dreaming prevalence (one or more lucid dreams in a lifetime); (b) frequent lucid dreaming (one or more lucid dreams in a month) or both. A quality effects meta-analysis allows for the minimisation of the influence of study methodological quality on overall model estimates. Following sensitivity analysis, a heterogeneous lucid dreaming prevalence data set of 34 studies yielded a mean estimate of 55%, 95% C. I. [49%, 62%] for which moderator analysis showed no systematic bias for suspected sources of variability. A heterogeneous lucid dreaming frequency data set of 25 studies yielded a mean estimate of 23%, 95% C. I. [20%, 25%], moderator analysis revealed no suspected sources of variability. These findings are consistent with earlier estimates of lucid dreaming prevalence and frequent lucid dreaming in the population but are based on more robust evidence. PMID:27337287

  12. [50 years WATL (Scientific Working Group for the Therapy of Lung Diseases)].

    PubMed

    Wirtz, H; Kropp, R; Behr, J; Costabel, U; Bonnet, R; Schönfeld, N; Prasse, A; Kardos, P; Seehausen, V; Loddenkemper, R

    2014-03-01

    On the occasion of the 50th anniversary of the Scientific Working Group for the Therapy of Lung Diseases (WATL) the history is described from its foundation to the present situation. Research topics during this long period are specified and the studies are briefly outlined. In the beginning, WATL was engaged mainly in studies on tuberculosis, later on, the spectrum of WATL was broadened considerably to diseases like sarcoidosis, pulmonary Langerhans' cell histiocytosis, pulmonary emphysema due to α1-antitrypsin deficiency, chronic obstructive bronchitis and bronchial asthma as well as nontuberculous mycobacterioses. Finally, realising that the methodological capabilities of WATL were not sufficient to conduct large trials in classical lung diseases considering current requirements, WATL has begun to acquire competence in rare lung diseases such as lymphangioleiomyomatosis and alveolar proteinosis. In addition, WATL is dedicated to educative aims by organising conferences on topics which are not part of main stream respiratory medicine. PMID:24595854

  13. Plan form changes of Gumara River channel over 50 years (Upper Blue Nile basin, Ethiopia)

    NASA Astrophysics Data System (ADS)

    Abate, Mengiste; Nyssen, Jan; Mehari, Michael

    2014-05-01

    Channel plan form changes were investigated along the 65 km long Gumara River in Lake Tana basin (Ethiopia) by overlaying information from aerial photographs and SPOT imagery. Two sets of aerial photographs (1957 and 1980) were scanned, and then orthorectified in ENVI 4.2 environment. Recent channel plan form information was extracted from SPOT images of 2006. ERDAS 2010 and ArcGIS 10.1 tools were used for the data preparation and analysis. The information on river plan form changes spans from 1957 to 2006 (49 years), during which time the Gumara catchment has been subjected to changes in land use/cover and increasing water abstraction, which may have affected its hydrogeomorphology. The results indicated that the lower reach of Gumara at its mouth has undergone major plan form changes. A delta of 1.12 km² was created between 1957 and 1980 and additional 1.00 km² land has been created between 1980 and 2006. The sinuosity of the plan form changed only slightly through the study period: 1.78 in 1957, 1.76 in 1980, and 1.81 in 2006. Comparison of cross sections at the hydrological gauging station showed that the river bed aggraded in the order of 1.5 m to 2.5 m for the period 1963-2009. The trend analysis of stream flow of Gumara River versus rainfall in the catchment also indicated that the bed level of the Gumara river at its gauging station has risen. From field observations, the impact of direct human interventions was identified. The building of artificial levees along the river banks has contributed to huge deposition in the river bed. At locations where intensive irrigation takes place in the floodplain, seepage water through the banks created river bank failure and modifications in plan form. The unstable segments of the river reach were identified and will be further analysed.

  14. Can changes in the distribution of lizard species over the past 50 years be attributed to climate change?

    NASA Astrophysics Data System (ADS)

    Wu, Jianguo

    2015-07-01

    We analyzed changes in the distributions of nine lizard species in China over the past 50 years and identified whether these changes could be attributed to climate change. Long-term records of lizard distributions, grey relational analysis, fuzzy set classification techniques, and attribution methods were used. The distribution of nearly half of the lizard species primarily shifted northward, westward, or eastward since the 1970s, and most changes were related to the thermal index. In response to climate change over the past 50 years, the distribution boundary and center of some species have mainly shifted northward, westward, or eastward, with some irregular shifting during the process. The observed and predicted changes in distribution were highly consistent for some lizard species. The changes in the northern and eastern distribution limits of nearly half of the lizard species and the western limits and distribution centers of several species can be attributed to climate change.

  15. Can changes in the distribution of lizard species over the past 50 years be attributed to climate change?

    NASA Astrophysics Data System (ADS)

    Wu, Jianguo

    2016-08-01

    We analyzed changes in the distributions of nine lizard species in China over the past 50 years and identified whether these changes could be attributed to climate change. Long-term records of lizard distributions, grey relational analysis, fuzzy set classification techniques, and attribution methods were used. The distribution of nearly half of the lizard species primarily shifted northward, westward, or eastward since the 1970s, and most changes were related to the thermal index. In response to climate change over the past 50 years, the distribution boundary and center of some species have mainly shifted northward, westward, or eastward, with some irregular shifting during the process. The observed and predicted changes in distribution were highly consistent for some lizard species. The changes in the northern and eastern distribution limits of nearly half of the lizard species and the western limits and distribution centers of several species can be attributed to climate change.

  16. Overview of patient dosimetry in diagnostic radiology in the USA for the past 50 years

    SciTech Connect

    Huda, Walter; Nickoloff, Edward L.; Boone, John M.

    2008-12-15

    This review covers the role of medical physics in addressing issues directly related to patient dosimetry in radiography, fluoroscopy, mammography, and CT. The sections on radiography and fluoroscopy radiation doses review the changes that have occurred during the last 50 to 60 years. A number of technological improvements have contributed to both a significant reduction in patient and staff radiation doses and improvements to the image quality during this period of time. There has been a transition from film-screen radiography with hand dip film processing to electronic digital imaging utilizing CR and DR. Similarly, fluoroscopy has progressed by directly viewing image intensifiers in darkened rooms to modern flat panel image receptor systems utilizing pulsed radiation, automated variable filtration, and digitally processed images. Mammography is one of the most highly optimized imaging procedures performed, because it is a repetitive screening procedure that results in annual radiation exposure. Mammography is also the only imaging procedure in the United States in which the radiation dose is regulated by the federal government. Consequently, many medical physicists have studied the dosimetry associated with screen-film and digital mammography. In this review, a brief history of mammography dose assessment by medical physicists is discussed. CT was introduced into clinical practice in the early 1970s, and has grown into one of the most important modalities available for diagnostic imaging. CT dose quantities and measurement techniques are described, and values of radiation dose for different types of scanner are presented. Organ and effective doses to adult patients are surveyed from the earliest single slice scanners, to the latest versions that include up to two x-ray tubes and can incorporate as many as 256 detector channels. An overview is provided of doses received by pediatric patients undergoing CT examinations, as well as methods, and results, of studies

  17. 50 years a biomedical engineer remembering a long and fascinating journey

    PubMed Central

    2012-01-01

    Looking back at one point of life appears as a nice exercise to round out and summarize. However, the objective should not be simply to tell a story; it must transmit a message to the young. To start with, two concepts are useful: Respect for others begins when you learn to laugh at yourself and, taken from an old saying, I did not want to be poor ... but money wouldn't make me rich. After elementary and high schools, during times of turmoil, I describe my engineering school years at the University of Buenos Aires and a working experience in an international telecommunications company. Significant events taught me a concept, rooted in another motto: Isn't this house nice? It is my house, and I love it very much. In 1960, I began my activities in the USA. A couple of bad decisions resulted in significant events for me teaching me an important truth: "Beware of golden promises; time is the most precious asset". Finally, in 1972, settled down in Tucumán until retirement in 2001, a long period of productive activity came about, not without difficulties and also stained by a dark political interval. Crises seem to characterize our generations in Argentina. Non-the-less, there were some real accomplishments: an undergraduate program in BME and a National BME Society (SABI) plus an archive of specialized published material. After spending time following retirement in Peru and Italy, my current activity came as unexpected dessert at the University of Buenos Aires, with a small research group, so offering the opportunity of transmitting what I still have available. PMID:22208504

  18. [50 years of total hip prosthesis--a tribute to Prof. Sir John Charnley].

    PubMed

    Mikić, Zelimir Dj; Lesić, Aleksandar R

    2013-01-01

    November 2012 marked the 50th anniversary of the first implantation of a successful and long-lived hip endoprosthesis, which was performed by Prof Sir John Charnley in the "Centre for Hip Surgery" at a small country place in the north-west England. John Charnley (1911-1982) finished medical school at the Victoria University of Manchester in 1935, and than started training in orthopaedics at the Manchester Royal Infirmary, and completed it after the Second World War, in which he served as a volunteer. After that he continued working in the same hospital, and, apart from that he worked as a lecturer at the University of Manchester, and from 1949 as a visiting surgeon in the Wrightington Hospital. In 1958 Charnley decided to put his efforts into the development of hip replacement research and surgery, and initiated the foundation of the "Centre for Hip Surgery" with Biomechanical laboratory in the Wrightington Hospital in 1960, where the intesive basic and clinical research started, and becuase of that Charnley in 1962 left Manchester and moved with a full time practice at the Wrightington Hospital. That period of research time was not easy, there were many "trial and tribulations", but, owing to the tenacity and inventive mind of Charnley, in 1962 a new prosthesis consisting of a cemented metal stem with a 22 mm head articulating with a cemented polyethilene acetabular component, and with a low frictional torque was designed. The first such prosthesis, which later produced excellent long-term results, was implanted on November 22nd, 1962, and today, when we look back over a distance of fifty years, we can conclude that that day could be considered as a beginning of a modem aloarthroplastic surgery, and certainly as one of the greatest orthopaedic advance in the whole of the 20th century; and all that was initiated and promoted by Prof. Sir John Charnley. PMID:24669557

  19. 50 years a biomedical engineer remembering a long and fascinating journey.

    PubMed

    Valentinuzzi, Max E

    2012-01-01

    Looking back at one point of life appears as a nice exercise to round out and summarize. However, the objective should not be simply to tell a story; it must transmit a message to the young. To start with, two concepts are useful: Respect for others begins when you learn to laugh at yourself and, taken from an old saying, I did not want to be poor ... but money wouldn't make me rich. After elementary and high schools, during times of turmoil, I describe my engineering school years at the University of Buenos Aires and a working experience in an international telecommunications company. Significant events taught me a concept, rooted in another motto: Isn't this house nice? It is my house, and I love it very much. In 1960, I began my activities in the USA. A couple of bad decisions resulted in significant events for me teaching me an important truth: "Beware of golden promises; time is the most precious asset". Finally, in 1972, settled down in Tucumán until retirement in 2001, a long period of productive activity came about, not without difficulties and also stained by a dark political interval. Crises seem to characterize our generations in Argentina. Non-the-less, there were some real accomplishments: an undergraduate program in BME and a National BME Society (SABI) plus an archive of specialized published material. After spending time following retirement in Peru and Italy, my current activity came as unexpected dessert at the University of Buenos Aires, with a small research group, so offering the opportunity of transmitting what I still have available. PMID:22208504

  20. Humid tropical rain forest has expanded into eucalypt forest and savanna over the last 50 years

    PubMed Central

    Tng, David Y P; Murphy, Brett P; Weber, Ellen; Sanders, Gregor; Williamson, Grant J; Kemp, Jeanette; Bowman, David M J S

    2012-01-01

    Tropical rain forest expansion and savanna woody vegetation thickening appear to be a global trend, but there remains uncertainty about whether there is a common set of global drivers. Using geographic information techniques, we analyzed aerial photography of five areas in the humid tropics of northeastern Queensland, Australia, taken in the 1950s and 2008, to determine if changes in rain forest extent match those reported for the Australian monsoon tropics using similar techniques. Mapping of the 1950s aerial photography showed that of the combined study area (64,430 ha), 63% was classified as eucalypt forests/woodland and 37% as rain forest. Our mapping revealed that although most boundaries remained stable, there was a net increase of 732 ha of the original rain forest area over the study period, and negligible conversion of rain forest to eucalypt forest/woodland. Statistical modeling, controlling for spatial autocorrelation, indicated distance from preexisting rain forest as the strongest determinant of rain forest expansion. Margin extension had a mean rate across the five sites of 0.6 m per decade. Expansion was greater in tall open forest types but also occurred in shorter, more flammable woodland vegetation types. No correlations were detected with other local variables (aspect, elevation, geology, topography, drainage). Using a geographically weighted mean rate of rain forest margin extension across the whole region, we predict that over 25% of tall open forest (a forest type of high conservation significance) would still remain after 2000 years of rain forest expansion. This slow replacement is due to the convoluted nature of the rain forest boundary and the irregular shape of the tall open forest patches. Our analyses point to the increased concentration of atmospheric CO2 as the most likely global driver of indiscriminate rain forest expansion occurring in northeastern Australia, by increasing tree growth and thereby overriding the effects of fire

  1. An observational study of comorbidity and healthcare utilisation among HIV-positive patients aged 50 years and over.

    PubMed

    Patel, Roshani; Moore, Thomas; Cooper, Vanessa; McArdle, Conor; Perry, Nicky; Cheek, Elizabeth; Gainsborough, Nicola; Fisher, Martin

    2016-07-01

    The number of HIV-positive people aged ≥50 years is rising each year. We measured the prevalence of non-infectious illnesses and their risk factors and described healthcare use in this UK population. A cross-sectional, observational study was conducted at an outpatient HIV specialist clinic in south east England. Patients age ≥50 years were invited to complete questionnaires measuring demographics, non-infectious illnesses, medication use, lifestyle and healthcare utilisation. The response rate was 67%. Of 299 participants, 84% reported ≥1 comorbid condition and 61% reported ≥2 (multimorbidity). Most commonly reported were high cholesterol, sexual dysfunction, hypertension and depression. In multivariate analyses, age, number of years HIV-positive and duration of antiretroviral therapy remained significant predictors of comorbidity when controlling for lifestyle factors (exercise, smoking and use of recreational drugs and alcohol). Use of non-HIV healthcare services was associated with increasing comorbidity, a longer duration of HIV and recreational drug use. The majority of HIV-patients aged ≥50 years reported multiple comorbidities and this was associated with polypharmacy and increased use of non-HIV services. Further research examining the quality, safety and patient experience of healthcare is needed to inform development of services to optimally meet the needs of older HIV-positive patients. PMID:26068965

  2. Detecting and Attributing the Effects of Climate Change on the Distributions of Snake Species Over the Past 50 Years

    NASA Astrophysics Data System (ADS)

    Wu, Jianguo

    2016-01-01

    It is unclear whether the distributions of snakes have changed in association with climate change over the past years. We detected the distribution changes of snakes over the past 50 years and determined whether the changes could be attributed to recent climate change in China. Long-term records of the distribution of nine snake species in China, grey relationship analysis, fuzzy sets classification techniques, the consistency index, and attributed methods were used. Over the past 50 years, the distributions of snake species have changed in multiple directions, primarily shifting northwards, and most of the changes were related to the thermal index. Driven by climatic factors over the past 50 years, the distribution boundary and distribution centers of some species changed with the fluctuations. The observed and predicted changes in distribution were highly consistent for some snake species. The changes in the northern limits of distributions of nearly half of the species, as well as the southern and eastern limits, and the distribution centers of some snake species can be attributed to climate change.

  3. [The campaign of returning to the ancient in sphygmology in the Republican Period as viewed from Mai xue cong shu (Series of Pulse Taking)].

    PubMed

    Han, Sujie; Hu, Xiaofeng

    2015-01-01

    From the Southern and Northern Dynasties to the beginning of the Northern Song Dynasty, the models of "master and apprentice" and "physician of long family tradition for generations" were the main ways for teaching medical knowledge. With the rapid amassment of medical books in the Due to the rapid transmission of western science and technology into China in the Republican period, the art of pulse taking had been treated as unscientific. Yao Xinyuan advocated the recovery of ancient pulse taking of the three-portion approach, i.e., taking the pulses at the neck, hands, and feet for comparison. To spread this idea, Yao and Zhang Ziying compiled the Mai xue cong shu (Series of Pulse Taking) in 1937-1947. Altogether 4 issues were published carrying 29 articles concerning the theoretical exploration, experimental research, and clinical practice. Their thinking and approaches were influential to the study and development of modern sphygmology. PMID:26268252

  4. 50 years of monitoring of the ozone layer in the Czech Republic - results and challenges

    NASA Astrophysics Data System (ADS)

    Vanicek, Karel; Skrivankova, Pavla; Metelka, Ladislav; Stanek, Martin

    2010-05-01

    Long-term observations of total ozone (TOZ) and vertical ozone profiles, the basic parameters of the ozone layer, have been performed at the Solar and Ozone Observatory (SOO) Hradec Kralove and at the Aerological Department (AD) Praha of the Czech Hydrometeorological Institute (CHMI) since 1961 and 1992 respectively. The Dobson and Brewer spectrophotometers regularly calibrated towards the international references and electro-chemical ECC ozone sondes are used for the measurements. The observations contribute to the global GAW and NDACC ozone monitoring systems. Up to now analyses of the data give the basic findings given bellow and documented in the presentation. Some of them have important implication to the international ozone monitoring infrastructure, as well. - The decrease of TOZ by about 5-7 % in the winter-spring months towards the pre ozone-hole period have occurred since the mid eighties. This is in good agreement by the magnitude and time with depletion of the ozone layer due to chemical destruction of ozone in the NH mid-latitudes. - Significant depletion 3-5 % of TOZ has been identified also in the summer season since the early nineties. As this can not be attributed to the man-made chemical processes a change in the UT/LS dynamics over Central Europe is the most probable reason. - Aerological measurements taken at AD show that the summer reduction of TOZ very well coincides with a change of UT/LS temperature that persists for about two decades over the Czech territory. Therefore it has a long-term character that can be regarded as a climate shift in UT/LS and need to be further investigated. - 15 years of unique simultaneous Dobson/Brewer observations of TOZ performed at SOO show systematic seasonal deviations between both data sets that exceed instrumental accuracy of measurements. The differences are mostly caused by different wavelengths and their ozone absorption coefficients used by both instruments. As the Brewer observations are being

  5. Medium Resolution Global Earth Observations with Landsat: Looking 35 Years Back and 50 Years Forward

    NASA Astrophysics Data System (ADS)

    Williams, D. L.; Irons, J. R.; Goward, S. N.

    2007-12-01

    The modern era of global medium resolution satellite remote sensing was inaugurated 35 years ago, in July 1972, with the launch of the first Landsat satellite carrying the Multispectral Scanner (MSS) sensor. Ten years after that first launch, Landsat 4 carried a much-improved sensor aloft, the Thematic Mapper. The TM provided better spatial resolution (30 m versus 79 m) than the MSS, as well as additional spectral bands in the mid- infrared (IR) and thermal IR regions. Roughly another decade later, in April 1999, the Enhanced Thematic Mapper Plus (ETM+) instrument was placed in orbit on Landsat 7. The ETM+ provided a new 15 m panchromatic band and a much-improved thermal band resolution (60 m versus 120 m). Through a combination of planning and good luck, the various Landsat missions have delivered a continuous set of calibrated, multispectral images of the Earth's surface spanning this entire 35-year time period. This imagery database has been used in agricultural evaluations, forest management inventories, geological surveys, water resource estimates, coastal zone appraisals, and a host of other applications to meet the needs of a very broad user community, including business, government, science, education, national security, and now -- even the casual observer -- as Landsat imagery provides the skeletal backbone of Google Earth. Landsat established the U.S. as the world leader in terrestrial remote sensing, contributed significantly to the understanding of the Earth's environment, spawned revolutionary uses of space-based data by the commercial value-added industry, and encouraged a new generation of commercial satellites that provide regional, high-resolution spatial images. In spite of the overall success of the Landsat series of satellites, the first 35 years of the Landsat legacy have been extremely challenging as the push to embrace new technologies was often questioned by those who simply wanted to maintain whatever the current capability was at that

  6. 50 Years: Veterinary Medicine.

    ERIC Educational Resources Information Center

    Narlesky, Lynn

    1998-01-01

    Describes the history, research, teaching strategies, and specialties of the University of California at Davis School of Veterinary Medicine. Documents effects of changing societal attitudes toward wildlife, pets, working animals, and food animals on curriculum, the systems approach to disease, comparative genetics, biotechnology, the ecology of…

  7. Celebrating 50 Years!

    ERIC Educational Resources Information Center

    Kristjansdottir, Anna

    2011-01-01

    The author congratulates members of the Association of Teachers of Mathematics (ATM) on celebrating the 50th anniversary of their annual conference. These conferences have kept the spirit alive from the early years, especially the engagement in investigative, collaborative, and reasoning activities. In the 50th year as an association, the author…

  8. Estimating the burden of hospitalization for pneumococcal pneumonia in a general population aged 50 years or older and implications for vaccination strategies

    PubMed Central

    Amodio, Emanuele; Costantino, Claudio; Boccalini, Sara; Tramuto, Fabio; Maida, Carmelo M; Vitale, Francesco

    2014-01-01

    Streptococcus pneumoniae is a major cause of human infectious diseases worldwide. Despite this documented evidence, data on pneumococcal disease rates among general populations are scant because of the frequent lack of cultural identification. In this study we propose a model for estimating the burden of pneumococcal pneumonia on hospitalizations. The study was performed by analyzing administrative and clinical data of patients aged 50 years or older, resident in Sicily, and hospitalized, from 2005 to 2012. Demographic information, admission/discharge dates, discharge status, and up to 6 discharge diagnoses coded according to ICD-9 CM were collected for each hospitalized patient. During the 8-year study period, a total of 72 372 hospitalizations with at least one ICD-9 CM diagnosis code suggestive of all-cause pneumonia were recorded. Of these, 1943 (2.7%) hospitalizations had specific ICD-9 CM diagnosis codes for pneumococcal pneumonia. According to the proposed model, 16 541 (22.9%) pneumonia out of all-cause pneumonia was estimated to be attributable to S. pneumoniae. Pneumococcal pneumonia and model-estimated pneumococcal pneumonia had mean hospitalization rates of 13.4 and 113.3/100 000, respectively, with a decreasing temporal trend. The risk of hospitalization for pneumococcal pneumonia was strongly correlated with age (P < 0.001). Our model provides data usable to construct suitable decisional models for the decision-makers and could allow to the responsibles of healthcare facilities to assess the budget impact if they hypothesize to offer vaccination for pneumococcal disease to certain cohorts of subjects aged 50 years or older. In our area, the high estimated hospitalization rates among adults aged ≥65 years suggest the need to implement effective preventive strategies (e.g., vaccination) tailored for these groups. PMID:24577505

  9. Vitamin B-6 intakes and plasma B-6 vitamer concentrations of men and women, 19-50 years of age.

    PubMed

    Driskell, J A; Giraud, D W; Mitmesser, S H

    2000-09-01

    The vitamin B-6 intakes and plasma B-6 vitamer levels of healthy nonsupplemented men and women, 19-24 and 25-50 years, were compared. The subjects did not take nutrient supplements or medications or use tobacco products. Subjects were grouped as follows: eight, 19-24 y men; nine, 25-50 y men; 11, 19-24 y women; and 13, 25-50 y women. The estimated vitamin B-6 intakes, obtained via 24-h recalls followed by 2-d food records, of the two groups of men were significantly higher (P < 0.05) than those of the two groups of women. Thirty-five percent of the women reported consuming less than the Estimated Average Requirement for vitamin B-6. The four gender: age groups had similar B-6 vitamer concentrations of plasma pyridoxal-5'-phosphate, 4-pyridoxic acid, pyridoxine, pyridoxamine, and pyridoxamine-5'-phosphate. Males 25-50 y had significantly higher (P < 0.05) plasma pyridoxal concentrations than the two groups of females. All subjects had pyridoxal-5'-phosphate concentrations indicative of vitamin B-6 adequacy. Generally the plasma B-6 vitamer concentrations of these men and women, 19-24 and 25-50 years of age, all having adequate vitamin B-6 status, were similar. PMID:11068702

  10. The use of Zostavax in Spain: the economic case for vaccination of individuals aged 50 years and older.

    PubMed

    Lopez-Belmonte, Juan Luis; Cisterna, Ramón; Gil de Miguel, Angel; Guilmet, Caroline; Bianic, Florence; Uhart, Mathieu

    2016-06-01

    Background Population aging brings up a number of health issues, one of which is an increased incidence of herpes zoster (HZ) and its complication, post-herpetic neuralgia (PHN). Zostavax vaccine has recently become available to prevent HZ and PHN. This study evaluates the cost-effectiveness of vaccination against HZ in Spain considering a vaccination of the population aged 50 years and older and comparing this to the current situation where no vaccination is being administered. Methods An existing, validated, and published economic model was adapted to Spain using relevant local input parameters and costs from 2013. Results Vaccinating 30% of the Spanish population aged 50 years and older resulted in €16,577/QALY gained, €2025/HZ case avoided, and €5594/PHN case avoided under the third-party payer perspective. From a societal perspective, the ICERs increased by 6%, due to the higher price of the vaccine. The number needed to vaccinate to prevent one case was 20 for HZ, and 63 for PHN3. Sensitivity analyses showed that the model was most sensitive to the HZ and PHN epidemiological data, the health state utilities values, and vaccine price used. Conclusion Considering an acceptable range of cost-effectiveness of €30,000-€50,000 per QALY gained, vaccination of the 50+ population in Spain against HZ with a new vaccine, Zostavax, is cost-effective and makes good use of the valuable healthcare budget. PMID:26808422

  11. EVALUATION OF THE RESULTS FROM ARTHROSCOPIC REPAIR ON ROTATOR CUFF INJURIES AMONG PATIENTS UNDER 50 YEARS OF AGE

    PubMed Central

    Miyazaki, Alberto Naoki; Fregoneze, Marcelo; Santos, Pedro Doneux; da Silva, Luciana Andrade; do Val Sella, Guilherme; Santos, Ruy Mesquita Maranhão; de Souza, Adriano; Checchia, Sérgio Luiz

    2015-01-01

    Objective: To assess the results from arthroscopic surgical treatment of rotator cuff injuries among patients under 50 years of age. Methods: Sixty-three patients with rotator cuff injuries who underwent arthroscopic surgical treatment performed by the Shoulder and Elbow Group of the Department of Orthopedics and Traumatology, in the Fernandinho Simonsen wing of Santa Casa Medical School, São Paulo, between August 1998 and December 2007, were reassessed. The study included all patients with rotator cuff injuries who were under 50 years of age and had been followed up postoperatively for at least 24 months. Results: According to the UCLA evaluation criteria, 59 patients (92%) showed excellent and good results; five (8%) showed fair results; and none showed poor results. The postoperative evaluation showed that the mean range of motion was 145° for elevation, 47° for lateral rotation and T10 for medial rotation. Unsatisfactory results were associated with prolonged duration of the injury, with a statistically significant relationship. Conclusion: Arthroscopic repair of rotator cuff injuries in young patients produces excellent or good results for most patients. PMID:27047819

  12. The Point of No Return

    PubMed Central

    Logan, Gordon D.

    2015-01-01

    Bartlett (1958) described the point of no return as a point of irrevocable commitment to action, which was preceded by a period of gradually increasing commitment. As such, the point of no return reflects a fundamental limit on the ability to control thought and action. I review the literature on the point of no return, taking three perspectives. First, I consider the point of no return from the perspective of the controlled act, as a locus in the architecture and anatomy of the underlying processes. I review experiments from the stop-signal paradigm that suggest that the point of no return is located late in the response system. Then I consider the point of no return from the perspective of the act of control that tries to change the controlled act before it becomes irrevocable. From this perspective, the point of no return is a point in time that provides enough “lead time” for the act of control to take effect. I review experiments that measure the response time to the stop signal as the lead time required for response inhibition in the stop-signal paradigm. Finally, I consider the point of no return in hierarchically controlled tasks, in which there may be many points of no return at different levels of the hierarchy. I review experiments on skilled typing that suggest different points of no return for the commands that determine what is typed and the countermands that inhibit typing, with increasing commitment to action the lower the level in the hierarchy. I end by considering the point of no return in perception and thought as well as action. PMID:25633089

  13. Association Between Self-efficacy and Participation in Community-Dwelling Manual Wheelchair Users Aged 50 Years or Older

    PubMed Central

    Sakakibara, Brodie M.; Routhier, François; Backman, Catherine L.; Eng, Janice J.

    2014-01-01

    Background Self-efficacy with using a wheelchair is an emerging construct in the wheelchair-use literature that may have implications for the participation frequency in social and personal roles of wheelchair users. Objectives The aim of this study was to investigate the direct and mediated effects of self-efficacy on participation frequency in community-dwelling manual wheelchair users aged 50 years or older. Design A cross-sectional study was conducted. Methods Participants were community-dwelling wheelchair users (N=124), 50 years of age or older (mean=59.7 years), with at least 6 months of experience with wheelchair use. The Late-Life Disability Instrument, the Wheelchair Use Confidence Scale, the Life-Space Assessment, and the Wheelchair Skills Test–Questionnaire Version measured participation frequency, self-efficacy, life-space mobility, and wheelchair skills, respectively. Multiple regression analyses with bootstrapping were used to investigate the direct and mediated effects. The International Classification of Functioning, Disability and Health was used to guide the analyses. Results Self-efficacy was a statistically significant determinant of participation frequency and accounted for 17.2% of the participation variance after controlling for age, number of comorbidities, and social support. The total mediating effect by life-space mobility, wheelchair skills, and perceived participation limitations was statistically significant (point estimate=0.14; bootstrapped 95% confidence interval=0.04, 0.24); however, the specific indirect effect by the wheelchair skills variable did not contribute to the total effect above and beyond the other 2 mediators. The mediated model accounted for 55.0% of the participation variance. Limitations Causality cannot be established due to the cross-sectional nature of the data, and the self-report nature of our data from a volunteer sample may be influenced by measurement bias or social desirability, or both. Conclusion Self

  14. REVIEW ARTICLE: The next 50 years of the SI: a review of the opportunities for the e-Science age

    NASA Astrophysics Data System (ADS)

    Foster, Marcus P.

    2010-12-01

    The International System of Units (SI) was declared as a practical and evolving system in 1960 and is now 50 years old. A large amount of theoretical and experimental work has been conducted to change the standards for the base units from artefacts to physical constants, to improve their stability and reproducibility. Less attention, however, has been paid to improving the SI definitions, utility and usability, which suffer from contradictions, ambiguities and inconsistencies. While humans can often resolve these issues contextually, computers cannot. As an ever-increasing volume and proportion of data about physical quantities is collected, exchanged, processed and rendered by computers, this paper argues that the SI definitions, symbols and syntax should be made more rigorous, so they can be represented wholly and unambiguously in ontologies, programs, data and text, and so the SI notation can be rendered faithfully in print and on screen.

  15. Statistical analysis of fires and explosions attributed to static electricity over the last 50 years in Japanese industry

    NASA Astrophysics Data System (ADS)

    Ohsawa, A.

    2011-06-01

    This paper presents a statistical analysis of 153 accidents attributable to static electricity in Japanese industry over the last 50 years. A more thorough understanding of their causes could help prevent similar incidents and identify hazards that could assist in the task of risk assessment. Most of the incidents occurred during operations performed by workers. In addition, more than 70% of the flammable atmospheres resulted from the presence of vapours. A noteworthy finding is that at least 70% of the ignitions were caused by isolated conductors including operators' bodies leading to spark discharges, which could have easily been prevented with earthing. These tendencies indicate that, when operators handle flammable liquids with any conductors, the ignition risk is significantly high. A serious lack of information regarding fundamental countermeasures for static electricity seems to be the main cause of such hazards. Only organised management, including education and risk communication, would prevent them.

  16. Posttraumatic stress disorder symptoms, physical health, and health care utilization 50 years after repeated exposure to a toxic gas.

    PubMed

    Ford, Julian D; Schnurr, Paula P; Friedman, Matthew J; Green, Bonnie L; Adams, Gary; Jex, Steve

    2004-06-01

    The posttraumatic sequelae of contaminant exposure are a contemporary international concern due to the threats posed to military personnel and civilians by war and bioterrorism. The role of PTSD symptoms as a mediator between potentially traumatic toxin exposure and physical health outcomes was examined with structural equation modeling in a probability sample of 302 male World War II-era U.S. military veterans 50 years after exposure to mustard gas tests. Controlling for age and psychological distress, the most parsimonious structural model involved PTSD symptoms mediating the relationship between toxin exposure and physical health problems, and physical health problems mediating the relationship between PTSD symptoms and outpatient health care utilization. Implications for researchers, mental health clinicians, and health care providers are discussed. PMID:15253090

  17. Changes in management and outcomes for children and adolescents with type 1 diabetes over the last 50 years.

    PubMed

    Fairchild, Jan

    2015-01-01

    Over the 50 years from 1964 to 2014, outcomes for children with type 1 diabetes have improved significantly, because of both technological advancements and changes in management philosophy. For the child with type 1 diabetes in 2014, intensive management with multiple daily injections or insulin pump therapy and the support of a specialist multidisciplinary team is now standard care. The main treatment goal is no longer the avoidance of hypoglycaemia, but the minimisation of hyperglycaemia and glucose variability, thereby reducing the risk of microvascular complications. However, the inherent burden of care and diligence required by patients and families, if they are to maintain optimal diabetes control, have not changed and may even have increased. While the long sought-after cure for diabetes remains elusive, artificial pancreas or closed-loop systems hold the most promise for improving the burden of care in the near term for children and adolescents with type 1 diabetes. PMID:25529223

  18. Size of coarse woody debris 5 years after girdling and removal treatments in 50-year-old Loblolly PIne Plantations

    SciTech Connect

    Edwards, M. Boyd

    2004-01-01

    PP 108 -113 in: Connor, Kristina F., ed. 2004. Proceedings of the 12th biennial southern silvicultural research conference. Gen. Tech. Rep. SRS71. Asheville, NC: U.S. Department of Agriculture, Forest Service, Southern Research Station. 594 p. Abstract: In 1996, a study began at Savannah River Site to investigate large-scale replicated forest areas to control coarse woody debris for integrated biodiversity objectives. Research design was a randomized complete block with four treatments replicated in four blocks, resulting in 16 plots. The treatments applied to 50-year-old loblolly pine stands were (1) control, (2) girdling of 25 percent of trees to create catastrophic simulation, (3) annual removal of down woody debris > 10 cm in diameter, and (4) annual removal of both standing and down woody debris > 10 cm in diameter. The study tracks coarse woody debris recruitment and loading, rates of decomposition, and effects on the forest ecosystem.

  19. 50 year trends in nitrogen use efficiency of world cropping systems: the relationship between yield and nitrogen input to cropland

    NASA Astrophysics Data System (ADS)

    Lassaletta, Luis; Billen, Gilles; Grizzetti, Bruna; Anglade, Juliette; Garnier, Josette

    2014-10-01

    Nitrogen (N) is crucial for crop productivity. However, nowadays more than half of the N added to cropland is lost to the environment, wasting the resource, producing threats to air, water, soil and biodiversity, and generating greenhouse gas emissions. Based on FAO data, we have reconstructed the trajectory followed, in the past 50 years, by 124 countries in terms of crop yield and total nitrogen inputs to cropland (manure, synthetic fertilizer, symbiotic fixation and atmospheric deposition). During the last five decades, the response of agricultural systems to increased nitrogen fertilization has evolved differently in the different world countries. While some countries have improved their agro-environmental performances, in others the increased fertilization has produced low agronomical benefits and higher environmental losses. Our data also suggest that, in general, those countries using a higher proportion of N inputs from symbiotic N fixation rather than from synthetic fertilizer have a better N use efficiency.

  20. Ion beams 12, Legnaro 6-8 June 2012, the 50 years (1961-2011) of the Legnaro Laboratory

    SciTech Connect

    Ricci, Renato Angelo

    2013-07-18

    A short review of the history of the Legnaro Laboratory is presented since its foundation 50 years ago by Prof. A. Rostagni of the University of Padova. The evolution of the Laboratory as a national reference center for fundamental and applied nuclear physics researches is outlined, pointing out its transformation into the INFN National Laboratories in 1968. After the first CN VdG Accelerator of 5.5 MV operating in 1961 and the AN2000 devoted to interdisciplinary researches (1971), i.e. 40 years ago, ten years later the advent of the first heavy ion facility in Italy, the XTU Tandem accelerator, and later on of the ALPI superconducting linear accelerator, was crucial for any future developments, not only in the field of nuclear physics but also for the evolution of interdisciplinary programmes with ion beams.

  1. Transient reactive papulotranslucent acrokeratoderma in a 50-year-old woman: case report and review of the literature.

    PubMed

    Adişen, Esra; Karaca, Fulya; Gürer, Mehmet Ali

    2008-01-01

    A 50-year-old woman who presented with intermittent symmetric edema and wrinkling of the palms after soaking in water was found to have transient reactive papulotranslucent acrokeratoderma (TRPA). This is the oldest patient ever reported to have this condition. The patient was advised to avoid water exposure as much as possible and to wear gloves. Topical treatment with 5% salicylic acid in Vaseline also provided some relief. TRPA presents with translucent, white, confluent papules that become evident on the palms after 3-5 minutes' exposure to water (the so-called 'hand-in-the-bucket' sign) and resolve within a short time after drying. It is a rare disorder with fewer than 40 cases having been reported in the world literature. The disease is seen mostly in female patients, with ages ranging from 6 to 44 years prior to our case in a 50-year-old woman. The most common histologic findings are hyperkeratosis and dilated eccrine ostia. The etiopathogenesis of the disease remains unknown but a transitory structural or functional alteration of components of the stratum corneum or aberration of the sweat duct have been considered. TRPA has been reported in patients with cystic fibrosis and more recently, in patients taking selective cyclo-oxygenase-2 inhibitors. Therefore, the pathogenesis of the condition appears to be related to increased water absorption as a result of an increased epidermal sodium level. Treatment with barrier creams such as hydrophilic petrolatum, glycerin emollients, 5-20% salicylic acid in Vaseline, 10% urea cream, and 12% ammonium lactate cream have been reported. Cases with associated hyperhidrosis respond well to aluminum chloride-containing products. PMID:18973409

  2. [Active management of the third stage of labour (AMTSL) - the end of a 50 years-dogma?].

    PubMed

    Rath, W

    2013-10-01

    Post-partum haemorrhage (PPH) is the leading cause of maternal mortality worldwide. Since more than 50 years AMTSL has been proposed for the prevention of PPH and is still recommended in current guidelines. The 3 key components of AMTSL are the prophylactic administration of oxytocin, clamping and cutting of the umbilical cord immediately after delivery of the baby and controlled cord traction. AMTSL has proven to reduce the rate of severe PPH by 70%. Despite of the long tradition of AMTSL it is still unclear, which of the 3 components significantly contributes to the reduction in PPH. Cochrane analyses and a recent metaanalysis gave strong evidence, that prophylactic oxytocin administration reduces the risk of PPH significantly, however, the optimal dose and mode of application is still a matter of debate.Until a little while ago no randomized controlled studies exist regarding the significance of controlled cord traction and the time of cord clamping in AMTSL. A randomized WHO trial 2012 and the 2013 published TRACOR (Traction of the CORd)-trial from France could clearly demonstrate that controlled cord traction is not associated with a significant reduction in postpartum blood loss and in the risk of severe PPH. A Cochrane analysis 2008 and a recent randomized trial from Sweden came to the conclusion, that there are no significant -differences between early (< 15 s) and delayed (> 1-3 min) cord clamping in the reduction of PPH and severe PPH. Uterine massage after delivery of the placenta, placental cord drainage and umbilical vein injection of uterotonics after delivery of the baby as part of AMTSL are not evidence-based methods. It has taken 50 years since AMTSL was first described for it to become clear that prophylactic oxytocin is the most important and the only evidence-based component of AMTSL. Future guidelines and textbooks should consider these new -findings. PMID:24170442

  3. Estimation of return periods for extreme sea levels: a simplified empirical correction of the joint probabilities method with examples from the French Atlantic coast and three ports in the southwest of the UK

    NASA Astrophysics Data System (ADS)

    Pirazzoli, Paolo Antonio; Tomasin, Alberto

    2007-04-01

    The joint probability method (JPM) to estimate the probability of extreme sea levels (Pugh and Vassie, Extreme sea-levels from tide and surge probability. Proc. 16th Coastal Engineering Conference, 1978, Hamburg, American Society of Civil Engineers, New York, pp 911 930, 1979) has been applied to the hourly records of 13 tide-gauge stations of the tidally dominated Atlantic coast of France (including Brest, since 1860) and to three stations in the southwest of the UK (including Newlyn, since 1916). The cumulative total length of the available records (more than 426 years) is variable from 1 to 130 years when individual stations are considered. It appears that heights estimated with the JPM are almost systematically greater than the extreme heights recorded. Statistical analysis shows that this could be due: (1) to surge tide interaction (that may tend to damp surge values that occur at the time of the highest tide levels), and (2) to the fact that major surges often occur in seasonal periods that may not correspond to those of extreme astronomical tides. We have determined at each station empirical ad hoc correction coefficients that take into account the above two factors separately, or together, and estimated return periods for extreme water levels also at stations where only short records are available. For seven long records, for which estimations with other computing methods (e.g. generalized extreme value [GEV] distribution and Gumbel) can be attempted, average estimations of extreme values appear slightly overestimated in relation to the actual maximum records by the uncorrected JPM (+16.7 ± 7.2 cm), and by the Gumbel method alone (+10.3 ± 6.3 cm), but appear closer to the reality with the GEV distribution (-2.0 ± 5.3 cm) and with the best-fitting correction to the JPM (+2.9 ± 4.4 cm). Because the GEV analysis can hardly be extended to short records, it is proposed to apply at each station, especially for short records, the JPM and the site-dependent ad

  4. 76 FR 14827 - Disclosure of Returns and Return Information to Designee of Taxpayer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... Internal Revenue Service 26 CFR Part 301 RIN 1545-BJ19 Disclosure of Returns and Return Information to Designee of Taxpayer AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of proposed... the period for submission to the IRS of taxpayer authorizations permitting disclosure of returns...

  5. The Nordic Model in Education: Education as Part of the Political System in the Last 50 Years

    ERIC Educational Resources Information Center

    Telhaug, Alfred Oftedal; Medias, Odd Asbjorn; Aasen, Petter

    2006-01-01

    This article describes, analyses and discusses the development of the Nordic school model in three phases of the post-war period, viewed in the light of the development of the political system throughout the period and in comparison with the development of the school system in the western world in this period. The "classical period" from 1945…

  6. Soil water capture trends over 50 years of single-cross maize (Zea mays L.) breeding in the US corn-belt.

    PubMed

    Reyes, Andres; Messina, Carlos D; Hammer, Graeme L; Liu, Lu; van Oosterom, Erik; Lafitte, Renee; Cooper, Mark

    2015-12-01

    Breeders have successfully improved maize (Zea mays L.) grain yield for the conditions of the US corn-belt over the past 80 years, with the past 50 years utilizing single-cross hybrids. Long-term improvement for grain yield under water-limited conditions has also been reported. Grain yield under water-limited conditions depends on water use, water use efficiency, and harvest index. It has been hypothesized that long-term genetic gain for yield could be due, in part, to increased water capture from the soil. This hypothesis was tested using a set of elite single-cross hybrids that were released by DuPont Pioneer between 1963 and 2009. Eighteen hybrids were grown in the field during 2010 and 2011 growing seasons at Woodland, CA, USA. Crops grew predominantly on stored soil water and drought stress increased as the season progressed. Soil water content was measured to 300cm depth throughout the growing season. Significant water extraction occurred to a depth of 240-300cm and seasonal water use was calculated from the change in soil water over this rooting zone. Grain yield increased significantly with year of commercialization, but no such trend was observed for total water extraction. Therefore, the measured genetic gain for yield for the period represented by this set of hybrids must be related to either increased efficiency of water use or increased carbon partitioning to the grain, rather than increased soil water uptake. PMID:26428065

  7. Hanford Area 1990 population and 50-year projections. [Appendix contains computer programming for population projections and graphs showing them by grid areas

    SciTech Connect

    Beck, D.M.; Scott, M.J.; Shindle, S.F.; Napier, B.A.; Thurman, A.G.; Batishko, N.C. ); Davis, M.D. ); Pittenger, D.B. )

    1991-10-01

    The complex and comprehensive safety analysis activities carried out at Hanford for nonreactor nuclear facilities require data from a number of scientific and engineering disciplines. The types of data that are required include data pertaining to current population and population projections. The types of data found in this document include 1990 census totals for residential population within a 50-mile radius of the 100-N, 200, 300, and 400 Area meteorological towers. This document also contains 50-year projections for residential populations within a 50-mile radius of these four meteorological towers. The analysis of population projections indicates that residential population within a 50-mile radius of the four meteorological towers in question will continue to grow through 2040, although at a slower rate each decade. In all cases, the highest growth is projected for the decade ending in the year 2000. The annual growth rate for this period is projected to be 0.646, 0.633, 0.543, and 0.570 in the 100-N, 200, 300, and 400 Areas, respectively. By 2040, these growth rates are projected to drop to 0.082, 0.068, 0.078, 0.078, respectively. 4 refs., 1 figs., 4 tabs.

  8. Soil water capture trends over 50 years of single-cross maize (Zea mays L.) breeding in the US corn-belt

    PubMed Central

    Reyes, Andres; Messina, Carlos D.; Hammer, Graeme L.; Liu, Lu; van Oosterom, Erik; Lafitte, Renee; Cooper, Mark

    2015-01-01

    Breeders have successfully improved maize (Zea mays L.) grain yield for the conditions of the US corn-belt over the past 80 years, with the past 50 years utilizing single-cross hybrids. Long-term improvement for grain yield under water-limited conditions has also been reported. Grain yield under water-limited conditions depends on water use, water use efficiency, and harvest index. It has been hypothesized that long-term genetic gain for yield could be due, in part, to increased water capture from the soil. This hypothesis was tested using a set of elite single-cross hybrids that were released by DuPont Pioneer between 1963 and 2009. Eighteen hybrids were grown in the field during 2010 and 2011 growing seasons at Woodland, CA, USA. Crops grew predominantly on stored soil water and drought stress increased as the season progressed. Soil water content was measured to 300cm depth throughout the growing season. Significant water extraction occurred to a depth of 240–300cm and seasonal water use was calculated from the change in soil water over this rooting zone. Grain yield increased significantly with year of commercialization, but no such trend was observed for total water extraction. Therefore, the measured genetic gain for yield for the period represented by this set of hybrids must be related to either increased efficiency of water use or increased carbon partitioning to the grain, rather than increased soil water uptake. PMID:26428065

  9. Mid-to long-term results of revision total hip replacement in patients aged 50 years or younger.

    PubMed

    Lee, P T H; Lakstein, D L; Lozano, B; Safir, O; Backstein, J; Gross, A E

    2014-08-01

    Revision total hip replacement (THR) for young patients is challenging because of technical complexity and the potential need for subsequent further revisions. We have assessed the survivorship, functional outcome and complications of this procedure in patients aged < 50 years through a large longitudinal series with consistent treatment algorithms. Of 132 consecutive patients (181 hips) who underwent revision THR, 102 patients (151 hips) with a mean age of 43 years (22 to 50) were reviewed at a mean follow-up of 11 years (2 to 26) post-operatively. We attempted to restore bone stock with allograft where indicated. Using further revision for any reason as an end point, the survival of the acetabular component was 71% (sd 4) and 54% (sd 7) at ten- and 20 years. The survival of the femoral component was 80% (sd 4) and 62% (sd 6) at ten- and 20 years. Complications included 11 dislocations (6.1%), ten periprosthetic fractures (5.5%), two deep infections (1.1%), four sciatic nerve palsies (2.2%; three resolved without intervention, one improved after exploration and freeing from adhesions) and one vascular injury (0.6%). The mean modified Harris Hip Score was 41 (10 to 82) pre-operatively, 77 (39 to 93) one year post-operatively and 77 (38 to 93) at the latest review. This overall perspective on the mid- to long-term results is valuable when advising young patients on the prospects of revision surgery at the time of primary replacement. PMID:25086120

  10. Hand grip strength and associated factors in non-institutionalised men and women 50 years and older in South Africa

    PubMed Central

    2014-01-01

    Background Little is known about the prevalence, predictors and gender differences in hand grip strength of older adults in Africa. This study aims to investigate social and health differences in hand grip strength among older adults in a national probability sample of older South Africans who participated in the Study of Global Ageing and Adults Health (SAGE wave 1) in 2008. Methods We conducted a national population-based cross-sectional study with a sample of 3840 men and women aged 50 years or older in South Africa. The questionnaire included socio-demographic characteristics, health variables, and anthropometric measurements. Linear multivariate regression analysis was performed to assess the association of social factors, health variables and grip strength. Results The mean overall hand grip strength was 37.9 kgs for men (mean age 61.1 years, SD = 9.1) and 31.5 kgs for women (mean age 62.0 years, SD = 9.7). In multivariate analysis among men, greater height, not being underweight and lower functional disability was associated with greater grip strength, and among women, greater height, better cognitive functioning, and lower functional disability were associated with greater grip strength. Conclusions Greater height and lower functional disability were found for both older South African men and women to be significantly associated with grip strength. PMID:24393403

  11. Nematode diversity, abundance and community structure 50 years after the formation of the volcanic island of Surtsey

    NASA Astrophysics Data System (ADS)

    Ilieva-Makulec, K.; Bjarnadottir, B.; Sigurdsson, B. D.

    2014-10-01

    The soil nematode fauna can give important insights into soil development and other habitat changes that occur during primary succession. We investigated the generic composition, density, distribution and community structure of nematodes 50 years after the formation of a pristine volcanic island, Surtsey, Iceland. Part of the island has received additional nutrient inputs from seagulls breeding there since 1985, while the reminder has been much less affected and is at present found at a different successional sere. In total, 25 genera of nematodes were identified, of which 14 were reported on Surtsey for the first time. Nematode communities were more diverse in the more infertile area outside the gull colony, where 24 genera were found, compared to 18 inside. The trophic structure of the nematode communities showed relatively higher abundance of fungal feeders in the infertile areas, but relatively more bacterial- and plant-feeders inside the colony. Nematode abundance in surface soil was, however, significantly higher within the gull colony, with 16.7 ind. cm-2 compared to 3.6 ind. cm-2 outside. A multivariate analysis indicated that the nematode abundance and distribution on Surtsey were most strongly related to the soil C : N ratio, soil acidity, plant cover and biomass, soil temperature and soil depth.

  12. Thermal comfort and tourism climate changes in the Qinghai-Tibet Plateau in the last 50 years

    NASA Astrophysics Data System (ADS)

    Li, Rui; Chi, Xiaoli

    2014-08-01

    In this paper, the thermal comfort and its changes in the Qinghai-Tibet Plateau over the last 50 years have been evaluated by using the physiological equivalent temperature (PET), and a more complete tourism climate picture is presented by the Climate-Tourism-Information Scheme (CTIS). The results show that PET classes in the Qinghai-Tibet Plateau cover six out of the nine-point thermal sensation scale — very cold, cold, cool, slightly cool, neutral and slightly warm — and cold stress is prevailing throughout the year. A small number of slightly cool/warm and neutral days occur in summer months. There occur no warm, hot and very hot days. The frequency of PET classes varies among regions, depending on their altitude/latitude conditions. Xining, Lhasa and Yushu are the top three cities in terms of thermal favorability. With global warming, annual cumulative number of thermally favorable days has been increasing, and that of cold stress has been reducing. The change is more obvious in lower elevation than that in higher elevation regions. The improving thermal comfort in the Qinghai-Tibet Plateau might be a glad tiding for local communities and tourists. Besides PET, CTIS can provide a number of additional bioclimatic information related to tourism and recreational activities. CTIS for Lhasa and Xining shows that sunshine is plentiful all the year round, and windy days occur frequently from late January to early May. This is a useful bioclimatic information for tourism authorities, travel agencies, resorts and tourists.

  13. Shale Failure Mechanics and Intervention Measures in Underground Coal Mines: Results From 50 Years of Ground Control Safety Research

    PubMed Central

    2015-01-01

    Ground control research in underground coal mines has been ongoing for over 50 years. One of the most problematic issues in underground coal mines is roof failures associated with weak shale. This paper will present a historical narrative on the research the National Institute for Occupational Safety and Health has conducted in relation to rock mechanics and shale. This paper begins by first discussing how shale is classified in relation to coal mining. Characterizing and planning for weak roof sequences is an important step in developing an engineering solution to prevent roof failures. Next, the failure mechanics associated with the weak characteristics of shale will be discussed. Understanding these failure mechanics also aids in applying the correct engineering solutions. The various solutions that have been implemented in the underground coal mining industry to control the different modes of failure will be summarized. Finally, a discussion on current and future research relating to rock mechanics and shale is presented. The overall goal of the paper is to share the collective ground control experience of controlling roof structures dominated by shale rock in underground coal mining. PMID:26549926

  14. Techniques for Interface Stress Measurements within Prosthetic Sockets of Transtibial Amputees: A Review of the Past 50 Years of Research.

    PubMed

    Al-Fakih, Ebrahim A; Abu Osman, Noor Azuan; Mahmad Adikan, Faisal Rafiq

    2016-01-01

    The distribution of interface stresses between the residual limb and prosthetic socket of a transtibial amputee has been considered as a direct indicator of the socket quality fit and comfort. Therefore, researchers have been very interested in quantifying these interface stresses in order to evaluate the extent of any potential damage caused by the socket to the residual limb tissues. During the past 50 years a variety of measurement techniques have been employed in an effort to identify sites of excessive stresses which may lead to skin breakdown, compare stress distributions in various socket designs, and evaluate interface cushioning and suspension systems, among others. The outcomes of such measurement techniques have contributed to improving the design and fitting of transtibial sockets. This article aims to review the operating principles, advantages, and disadvantages of conventional and emerging techniques used for interface stress measurements inside transtibial sockets. It also reviews and discusses the evolution of different socket concepts and interface stress investigations conducted in the past five decades, providing valuable insights into the latest trends in socket designs and the crucial considerations for effective stress measurement tools that lead to a functional prosthetic socket. PMID:27447646

  15. Techniques for Interface Stress Measurements within Prosthetic Sockets of Transtibial Amputees: A Review of the Past 50 Years of Research

    PubMed Central

    Al-Fakih, Ebrahim A.; Abu Osman, Noor Azuan; Mahmad Adikan, Faisal Rafiq

    2016-01-01

    The distribution of interface stresses between the residual limb and prosthetic socket of a transtibial amputee has been considered as a direct indicator of the socket quality fit and comfort. Therefore, researchers have been very interested in quantifying these interface stresses in order to evaluate the extent of any potential damage caused by the socket to the residual limb tissues. During the past 50 years a variety of measurement techniques have been employed in an effort to identify sites of excessive stresses which may lead to skin breakdown, compare stress distributions in various socket designs, and evaluate interface cushioning and suspension systems, among others. The outcomes of such measurement techniques have contributed to improving the design and fitting of transtibial sockets. This article aims to review the operating principles, advantages, and disadvantages of conventional and emerging techniques used for interface stress measurements inside transtibial sockets. It also reviews and discusses the evolution of different socket concepts and interface stress investigations conducted in the past five decades, providing valuable insights into the latest trends in socket designs and the crucial considerations for effective stress measurement tools that lead to a functional prosthetic socket. PMID:27447646

  16. Shale Failure Mechanics and Intervention Measures in Underground Coal Mines: Results From 50 Years of Ground Control Safety Research

    NASA Astrophysics Data System (ADS)

    Murphy, M. M.

    2016-02-01

    Ground control research in underground coal mines has been ongoing for over 50 years. One of the most problematic issues in underground coal mines is roof failures associated with weak shale. This paper will present a historical narrative on the research the National Institute for Occupational Safety and Health has conducted in relation to rock mechanics and shale. This paper begins by first discussing how shale is classified in relation to coal mining. Characterizing and planning for weak roof sequences is an important step in developing an engineering solution to prevent roof failures. Next, the failure mechanics associated with the weak characteristics of shale will be discussed. Understanding these failure mechanics also aids in applying the correct engineering solutions. The various solutions that have been implemented in the underground coal mining industry to control the different modes of failure will be summarized. Finally, a discussion on current and future research relating to rock mechanics and shale is presented. The overall goal of the paper is to share the collective ground control experience of controlling roof structures dominated by shale rock in underground coal mining.

  17. The Utility of Capsule Endoscopy in Patients under 50 Years of Age with Recurrent Iron Deficiency Anaemia: Is the Juice Worth the Squeeze?

    PubMed Central

    Sidhu, Prabhjot Singh; McAlindon, Mark E.; Drew, Kaye; Sidhu, Reena

    2015-01-01

    Background and Aims. The role of capsule endoscopy (CE) in the <50 years of age patients with iron deficiency anaemia (IDA) remains unclear. We aim to assess its utility in this cohort. Methods. All patients referred for CE for recurrent IDA were included retrospectively. Patients were divided into Group 1 (<50 years) and Group 2 (≥50 years). Results. There were 971 patients with recurrent IDA and 28% belonged to Group 1. The mean age was 40 years in this group with a DY of 28% (n = 76). Significant diagnoses included erosions and ulcers (26%; n = 71), small bowel (SB) angioectasia (AE) (10%; n = 27), SB tumours (3%; n = 7), Crohn's disease (3%; n = 7), SB bowel strictures (1%; n = 3), and SB varices (1%; n = 2). On logistic regression, the presence of diabetes (P = 0.02) and the use of warfarin (P = 0.049) was associated with increased DY. The DY in Group 2 was 38% which was significantly higher than in Group 1 (P = 0.02). While SB tumours were equally common in both groups, AE was commoner in Group 2 (P < 0.001). Conclusion. A significant proportion of patients <50 years are referred for CE. Although the DY is lower compared to those ≥50 years, significant pathology is found in this age group. CE is advisable in patients <50 years old with recurrent IDA and negative bidirectional endoscopies. PMID:25922603

  18. Setting in evidence of the new climatic tendency in Algeria by the analysis of the main variables of the climate : Survey of the chronological sets on more of 50 years.

    NASA Astrophysics Data System (ADS)

    Zeineddine, N.

    2009-09-01

    Setting in evidence of the new climatic tendency in Algeria by the analysis of the main variables of the climate : Survey of the chronological sets on more of 50 years. In the present conditions of the global climatic changes, North Africa and Maghreb, observe these last years of the distresses without precedent. This new tendency expresses itself by a rise of the temperatures confirmed in several countries. In the same way to this rise, one also notes an intensification of the climatic cycles (more and more humid humid periods, more and more dry dry periods). So, after the long droughts observed in the years four - twenty and ninety, the a lot more humid period bootjack is noted in the whole region. These phases are punctuated however sometimes of stern droughts, that been the case in 2000 to Morocco and in Algeria. The humid phases are as for them more and more frequent and are characterized henceforth by very intense rainy episodes. Repeatedly, serious floodings touched these countries. In 2002 in Algeria, it is the capital that has been touched, the districts of Bab - El Wadi was heavily damaged. In the valley of the Soummam, the town of Bejaïa was the theater of important phenomena of urban flooding in 2007. In the Algerian Sahara, heavy rains provoked the rise in the water level of the wadi M' Zab and the submersion of the city of Ghardaïa. All as Algeria, Tunisia has also been touched by these phenomena. The city of Tunis knew a tragic episode thus in 2007. To the west extreme of North Africa in 2002, Morocco has been hit by important floodings that made 35 deaths.. Progressively, the climatic conditions become unusual. The signs of the changes prove to be even more meaningful with the records of rain for the agricultural year 2008 / 2009 in the under region from the Maghreb (Morocco - Algeria). Qualified of exceptional and historic, rains have generously supplied the watertables, carrying the water security margin to close to two years in drinking water

  19. "50 Cents, 50 Years": Finding the Value of the Space Program on the Back of a Quarter

    NASA Technical Reports Server (NTRS)

    Horack, John M.

    2008-01-01

    Brief presentation highlighting the accomplishments of NASA upon its 50th anniversary. NASA's first manned space flight, voyage to the moon, planetary exploration, space station construction, international cooperation, space habitat construction and the deployment of multiple satellites including the Hubble Space Telescope, Gamma Ray Observatory, Magellan and Galileo. More recent efforts include the construction of the Ares transportation system and a return to human exploration beyond low-Earth orbit. The author also urges for continued space exploration via the National Space Policy through the authorization of Congress.

  20. Dynamics of rock glaciers and debris-covered glaciers in the Central Chilean Andes over the last 50 years

    NASA Astrophysics Data System (ADS)

    Bodin, Xavier; Brenning, Alexander; Rojas Marchini, Fernanda

    2010-05-01

    In the semiarid Central Andes of Chile at 33.5°S., mountain permafrost is widely present above 3500-4000 m asl, especially in the form of rock glaciers, which often coexist with glaciers and debris-covered glaciers. This peculiar configuration of the cryosphere involves complex and poorly known responses of its components to climate change. Our study area in the Laguna Negra catchment is part of a watershed that provides up to two-thirds of the drinking water supplies to Chile's capital Santiago (5.5 million inhabitants) during the dry summer months. The 35 km² watershed contains 2.3 km² of uncovered glaciers, 0.9 km² of debris-covered glacier area and 4.3 km² of rock glaciers, and hosts the longest series of glacier mass balance measurement in Chile (Echaurren Norte glacier). Using orthorectified aerial photographs of 1956 and 1996 and a high resolution satellite image of 2008, we mapped the geometric changes that affected the glacier and the debris-covered glacier of the Punta Negra sub-catchment during the last 50 years. Surface displacements and volume changes were estimated based on 1956 and 1996 digital elevation models (DEMs), and the total loss of water equivalent in the catchment was quantified. At a shorter time scale, rock glaciers and a debris-covered glacier are being monitored since 2004, providing insights into their kinematics and near-surface thermal regime. The orthophotos reveal a 44.7% reduction of the uncovered glacier area between 1955 and 1996, and only small surface changes between 1996 and 2008. The volume reduction of both uncovered and debris-covered glaciers is estimated at at least 3.9 million m3 water equivalent between 1955 and 1996. The second noticeable change is the growth of the thermokarst areas on the debris-covered glacier, with the formation of new and the widening and deepening of existing melt-out depressions between 1955 and 2008. The thermal monitoring revealed that, in 2003/04, the mean annual ground surface

  1. [Clinical and tomographic aspects of hemorrhagic cerebrovascular disease associated with hypertensive crisis in adults under 50 years of age].

    PubMed

    Arismendi-Morillo, G J; Fernández-Abreu, M; Añez-Moreno, R E

    2000-09-01

    The purpose of this study was to analyze both the clinical and tomographic aspects of the hemorrhagic cerebrovascular disease (HCd), associated with hypertensive crisis in adults under 50 years of age. Forty six patients, who were not under anticoagulant therapy, were not using illegal drugs, who had not a cerebral tumor disease, and who had neither arteriovenous malformations nor past traumatic episodes, were studied. Seventy eight percent of the patients had preexisted arterial hypertension, 30% of them had at least a previous emergency for a hypertensive crisis. Mortality for intracerebral hematoma (ICH) and for subarachnoid hemorrhage (SAH) was 21% and 23% respectively. In 68% of the cases, ICH was located in the deep structures of the brain. Asymmetric ventricular system, compression or the absence of mesencephalic cisterna were significantly associated (p > 0.01; p > 0.001 respectively) with higher mortality. There was not a significant difference between the deceased and the survivors in relation with their systolic and diastolic arterial pressure on admission to the emergency unit. A significant positive relation was found between the severity of the injury (percentage of patients with an Scale Coma Glasgow < or = 8 points) and the mortality percentage for the type of HCd (r = 0.81 for ICH; p < 0.001, r = 0.98 for SAH; p < 0.001). Age and a low Scale Coma Glasgow score on the admission, represent unfavorable prognostic factors. Due to the different criteria used to evaluate the tomographic characteristics of intracerebral hematomas, comparisons of the present results with other findings can be difficult. PMID:11029832

  2. The new ICSU World Data System: Building on the 50 Year Legacy of the World Data Centers

    NASA Astrophysics Data System (ADS)

    Clark, D. M.; Minster, J.

    2008-12-01

    The International Council for Science (ICSU) World Data Center (WDC) system was established in 1957 in response to the data needs of the International Geophysical Year (IGY). Its holdings included a wide range of solar, geophysical, environmental, and human dimensions data. The WDC system developed many innovative data management and data exchange procedures and techniques over the last 50 years, which mitigated effectively the impact of global politics on science. The beginning of the 21st century has seen new ICSU requirements for management of large and diverse scientific data from major international programs such as the Group on Earth Observations (GEO) Global Earth Observation Systems of Systems (GEOSS), the International Polar Year (IPY), the Millennium Ecosystems Assessment (MEA), and the Coordinated Energy and Water Cycle Observation Project (CEOP). As a consequence, a completely new ICSU data activity, the World Data System (WDS) is being created which will incorporate the major ICSU data activities including in particular the WDCs and the Federation of Astronomical and Geophysical Data- Analysis Services. Using the legacy of the WDC system, the WDS will place an emphasis on new information technology as applied to modern data management techniques and international data exchange. The new World Data System will support ICSU's enduring mission and objectives, ensuring the long-term stewardship and provision of quality-assessed data and data services to the international science community and other stakeholders. It will have a broader disciplinary and geographic base than the current ICSU networks and be recognized as a world-wide "community of excellence" for data issues. It will use state-of-the-art systems interoperability, international very high bandwidth capabilities and a coordinated focus on topics such as virtual observatories. It will also encourage the establishment of new data centers and services, using modern paradigms for their establishment

  3. 50-year trends in US socioeconomic inequalities in health: US-born Black and White Americans, 1959–2008

    PubMed Central

    Krieger, Nancy; Kosheleva, Anna; Waterman, Pamela D; Chen, Jarvis T; Beckfield, Jason; Kiang, Mathew V

    2014-01-01

    Background: Debates exist over whether health inequities are bound to rise as population health improves, due to health improving more quickly among the better off, with most analyses focused on mortality data. Methods: We analysed 50 years of socioeconomic inequities in measured health status among US-born Black and White Americans, using data from the National Health Examination Surveys (NHES) I-III (1959–70), National Health and Nutrition Examination Surveys (NHANES) I-III (1971–94) and NHANES 1999–2008. Results: Absolute US socioeconomic health inequities for income percentile and education variously decreased (serum cholesterol; childhood height), stagnated [systolic blood pressure (SBP)], widened [body mass index (BMI), waist circumference (WC)] and in some cases reversed (age at menarche), even as on-average values rose (BMI, WC), idled (childhood height) and fell (SBP, serum cholesterol, age at menarche), with patterns often varying by race/ethnicity and socioeconomic measure; similar results occurred for relative inequities. For example, for WC, the adverse 20th (low) vs 80th (high) income percentile gap increased only among Whites (NHES I: 0.71 cm [95% confidence interval (CI) −0.74, 2.16); NHANES 2005–08: 2.10 (95% CI 0.96, 3.62)]. By contrast, age at menarche for girls in the 20th vs 80th income percentile among Black girls remained consistently lower, by 0.34 years (95% CI 0.12, 0.55) whereas among White girls the initial null difference became inverse [NHANES 2005–08: −0.49 years (95% CI −0.86, −0.12; overall P = 0.0015)]. Adjusting for socioeconomic position only modestly altered Black/White health inequities. Conclusions: Health inequities need not rise as population health improves. PMID:24639440

  4. Performance And Agreement Of Risk Stratification Instruments For Postoperative Delirium In Persons Aged 50 Years Or Older

    PubMed Central

    Jansen, Carolien J.; Absalom, Anthony R.; de Bock, Geertruida H.; van Leeuwen, Barbara L.; Izaks, Gerbrand J.

    2014-01-01

    Several risk stratification instruments for postoperative delirium in older people have been developed because early interventions may prevent delirium. We investigated the performance and agreement of nine commonly used risk stratification instruments in an independent validation cohort of consecutive elective and emergency surgical patients aged ≥50 years with ≥1 risk factor for postoperative delirium. Data was collected prospectively. Delirium was diagnosed according to DSM-IV-TR criteria. The observed incidence of postoperative delirium was calculated per risk score per risk stratification instrument. In addition, the risk stratification instruments were compared in terms of area under the receiver operating characteristic (ROC) curve (AUC), and positive and negative predictive value. Finally, the positive agreement between the risk stratification instruments was calculated. When data required for an exact implementation of the original risk stratification instruments was not available, we used alternative data that was comparable. The study population included 292 patients: 60% men; mean age (SD), 66 (8) years; 90% elective surgery. The incidence of postoperative delirium was 9%. The maximum observed incidence per risk score was 50% (95%CI, 15–85%); for eight risk stratification instruments, the maximum observed incidence per risk score was ≤25%. The AUC (95%CI) for the risk stratification instruments varied between 0.50 (0.36–0.64) and 0.66 (0.48–0.83). No AUC was statistically significant from 0.50 (p≥0.11). Positive predictive values of the risk stratification instruments varied between 0–25%, negative predictive values between 89–95%. Positive agreement varied between 0–66%. No risk stratification instrument showed clearly superior performance. In conclusion, in this independent validation cohort, the performance and agreement of commonly used risk stratification instruments for postoperative delirium was poor. Although some caution is

  5. CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation?

    PubMed Central

    2010-01-01

    We assessed CD4 count at initial presentation for HIV care among ≥50-year-olds from 1997-2007 in 13 US and Canadian clinical cohorts and compared to <50-year-olds. 44,491 HIV-infected individuals in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) were included in our study. Trends in mean CD4 count (measured as cells/mm3) and 95% confidence intervals ([,]) were determined using linear regression stratified by age category and adjusted for gender, race/ethnicity, HIV transmission risk and cohort. From 1997-2007, the proportion of individuals presenting for HIV care who were ≥50-years-old increased from 17% to 27% (p-value < 0.01). The median CD4 count among ≥50 year-olds was consistently lower than younger adults. The interaction of age group and calendar year was significant (p-value <0.01) with both age groups experiencing modest annual improvements over time (< 50-year-olds: 5 [4 , 6] cells/mm3; ≥50-year-olds: 7 [5 , 9] cells/mm3), after adjusting for sex, race/ethnicity, HIV transmission risk group and cohort; however, increases in the two groups were similar after 2000. A greater proportion of older individuals had an AIDS-defining diagnosis at, or within three months prior to, first presentation for HIV care compared to younger individuals (13% vs. 10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed. PMID:21159161

  6. Geological Evolution of the Moon: Recent Findings, New Perspectives and Fundamental Questions from 50 Years of Solar System Exploration

    NASA Astrophysics Data System (ADS)

    Head, J. W.

    2012-12-01

    The Earth's Moon provides a fundamental frame of reference for understanding the formation, early history, and evolution of terrestrial planetary bodies. More than 50 years of exploration of the Moon and the Solar System has placed the Moon in the context of the other planetary bodies, including Earth. We look to the well-explored and characterized Moon for an understanding of the nature of its chemical layering (crust, mantle and core), its mechanical layering (lithosphere, asthenosphere), and the nature of its key geological processes (accretion, differentiation, thermal evolution, impact cratering, volcanism and tectonism). What has the Golden Age of Solar System Exploration taught us about the utility and applicability of the lunar historical paradigm? What new questions has it raised? What is thematic in terms of planetary evolution and what is unique to the Moon? How do answers to these three questions inform us about the major outstanding questions concerning the history of the Earth? How do they frame a new paradigm for future lunar exploration? Key questions and focal points include: 1) Does the accretionary history forming the Moon following the Earth impact set the Moon on a different course than bodies accreted by conventional means? 2) How can the impact cratering record of the Moon provide keys to the early bombardment history of the inner solar system, including the "lunar cataclysm"? 3) What is the nature of the lunar magma ocean-derived primary crust and its segregation from the mantle? 4) Are lunar differentiation and primary crustal formation processes and products thematic, unique, or both? 5) What is the nature and significance of the aftermath of primary crustal formation, density stratification and inversion? 6) What are the causes of the lunar magnetic field and its initiation and cessation? 7) What is the process of impact basin formation and how does it change the thickness, physical state, thermal structure, geochemistry and petrology of

  7. Patient Perspectives on Online Health Information and Communication With Doctors: A Qualitative Study of Patients 50 Years Old and Over

    PubMed Central

    2015-01-01

    Background As health care systems around the world shift toward models that emphasize self-care management, there is increasing pressure for patients to obtain health information online. It is critical that patients are able to identify potential problems with using the Internet to diagnose and treat a health issue and that they feel comfortable communicating with their doctor about the health information they acquire from the Internet. Objective Our aim was to examine patient-identified (1) problems with using the Internet to identify and treat a health issue, (2) barriers to communication with a doctor about online health information seeking, and (3) facilitators of communication with a doctor about patient searches for health information on the Internet. Methods For this qualitative exploratory study, semistructured interviews were conducted with a sample of 56 adults age 50 years old and over. General concerns regarding use of the Internet to diagnose and treat a health issue were examined separately for participants based on whether they had ever discussed health information obtained through the Internet with a doctor. Discussions about barriers to and facilitators of communication about patient searches for health information on the Internet with a doctor were analyzed using thematic analysis. Results Six higher-level general concerns emerged: (1) limitations in own ability, (2) credibility/limitations of online information, (3) anxiety, (4) time consumption, (5) conflict, and (6) non-physical harm. The most prevalent concern raised by participants who communicated with a doctor about their online health information seeking related to the credibility or limitations in online information. Participants who had never communicated with a doctor about their online health information seeking most commonly reported concerns about non-physical harm. Four barriers to communication emerged: (1) concerns about embarrassment, (2) concerns that the doctor doesn’t want

  8. Internet-based vestibular rehabilitation for adults aged 50 years and over: a protocol for a randomised controlled trial

    PubMed Central

    Geraghty, Adam W A; Kirby, Sarah; Essery, Rosie; Little, Paul; Bronstein, Adolfo; Turner, David; Stuart, Beth; Andersson, Gerhard; Carlbring, Per; Yardley, Lucy

    2014-01-01

    Introduction Dizziness is highly prevalent in older adults and can lead to falls, fear of falling, loss of confidence, anxiety and depression. Vestibular rehabilitation (VR) exercises are effective in reducing dizziness due to vestibular dysfunction, but access to trained therapists is limited. Providing dizzy patients with booklets teaching them how to carry out VR exercises has been shown to be a cost-effective way of managing dizziness in primary care. Internet-based intervention delivery has many advantages over paper-based methods, including the provision of video instructions, automated tailoring and symptom-related feedback. This trial will examine whether an internet-based VR intervention is (1) effective in reducing dizziness and (2) a cost-effective primary care treatment option. Methods/analysis This will be a single blind, randomised controlled trial carried out in UK primary care. A stand-alone internet-based VR intervention will be compared with routine care in 262 dizzy patients aged 50 years and over. Measures will be taken at baseline, 3 and 6 months. Our primary outcome measure will be the effectiveness of the intervention in reducing dizziness symptoms compared with routine care at 6 months. Cost-effectiveness will be examined along with the effect of the intervention on dizziness-related disability and symptoms of depression and anxiety. Psychological process variables including expectancy, self-efficacy and acceptance will be explored in relation to adherence and symptom reduction. Ethics/dissemination This trial has undergone ethical scrutiny and been approved by an NHS Research Ethics Committee, Southampton A REC Reference: 13/SC/0119. The findings of this trial will be disseminated to the scientific community through presentations at national and international conferences, and by publishing in peer review journals. Findings will be disseminated to the public through targeted press releases. This trial will provide valuable information on

  9. Engineering America's Current and Future Space Transportation Systems: 50 Years of Systems Engineering Innovation for Sustainable Exploration

    NASA Technical Reports Server (NTRS)

    Dmbacher, Daniel L.; Lyles, Garry M.; McConnaughey, Paul

    2008-01-01

    Over the past 50 years, the National Aeronautics and Space Administration (NASA) has delivered space transportation solutions for America's complex missions, ranging from scientific payloads that expand knowledge, such as the Hubble Space Telescope, to astronauts and lunar rovers destined for voyages to the Moon. Currently, the venerable Space Shuttle, which has been in service since 1981, provides the United States' (U.S.) capability for both crew and heavy cargo to low-Earth orbit to' construct the International Space Station, before the Shuttle is retired in 2010. In the next decade, NASA will replace this system with a duo of launch vehicles: the Ares I Crew Launch Vehicle and the Ares V Cargo Launch Vehicle (Figure 1). The goals for this new system include increased safety and reliability coupled with lower operations costs that promote sustainable space exploration for decades to come. The Ares I will loft the Orion Crew Exploration Vehicle, while the heavy-lift Ares V will carry the Altair Lunar Lander and the equipment and supplies needed to construct a lunar outpost for a new generation of human and robotic space pioneers. This paper will provide details of the in-house systems engineering and vehicle integration work now being performed for the Ares I and planned for the Ares V. It will give an overview of the Ares I system-level test activities, such as the ground vibration testing that will be conducted in the Marshall Center's Dynamic Test Stand to verify the integrated vehicle stack's structural integrity and to validate computer modeling and simulation (Figure 2), as well as the main propulsion test article analysis to be conducted in the Static Test Stand. These activities also will help prove and refine mission concepts of operation, while supporting the spectrum of design and development work being performed by Marshall's Engineering Directorate, ranging from launch vehicles and lunar rovers to scientific spacecraft and associated experiments

  10. Does self-rated health predict death in adults aged 50 years and above in India? Evidence from a rural population under health and demographic surveillance

    PubMed Central

    Hirve, Siddhivinayak; Juvekar, Sanjay; Sambhudas, Somnath; Lele, Pallavi; Blomstedt, Yulia; Wall, Stig; Berkman, Lisa; Tollman, Steve; Ng, Nawi

    2012-01-01

    Background The Study on Global Ageing and Adult Health (SAGE) aims to improve empirical understanding of health and well-being of adults in developing countries. We examine the role of self-rated health (SRH) in predicting mortality and assess how socio-demographic and other disability measures influence this association. Methods In 2007, a shortened SAGE questionnaire was administered to 5087 adults aged ≥50 years under the Health Demographic Surveillance System in rural Pune district, India. Respondents rated their own health with a single global question on SRH. Disability and well-being were assessed using the WHO Disability Assessment Schedule Index, Health State Score and quality-of-life score. Respondents were followed up every 6 months till June 2011. Any change in spousal support, migration or death during follow-up was updated in the SAGE dataset. Results In all, 410 respondents (8%) died in the 3-year follow-up period. Mortality risk was higher with bad/very bad SRH [hazard ratio (HR) in men: 3.06, 95% confidence interval (CI): 1.93–4.87; HR in women: 1.64, 95% CI: 0.94–2.86], independent of age, disability and other covariates. Disability measure (WHO Disability Assessment Schedule Index) and absence of spousal support were also associated with increased mortality risk. Conclusion Our findings confirm an association between bad/very bad SRH and mortality for men, independent of age, socio-demographic factors and other disability measures, in a rural Indian population. This association loses significance in women when adjusted for disability. Our study highlights the strength of nesting cross-sectional surveys within the context of the Health Demographic Surveillance System in studying the role of SRH and mortality. PMID:23175517

  11. Changes in Carbon Pools 50 Years after Reversion of a Landscape Dominated by Agriculture to Managed Forests in the Upper Southeastern Atlantic Coastal Plain

    NASA Astrophysics Data System (ADS)

    Dai, Z.; Trettin, C.; Parresol, B. R.; Li, C.

    2010-12-01

    The landscape of the upper coastal plain of South Carolina in the late 1940’s was typified by rural agricultural communities and farms comprising cleared fields and mixed-use woodlots. Approximately 80,000 ha of that landscape was appropriated by the US Government in the early 1950’s to form the Savannah River Site which is now managed by the US Dept. of Energy. The US Forest Service was engaged to reforest the agricultural parcels, 40% of the tract, and to develop sustainable management practices for the woodlots and restored areas. As part of the acquisition process in 1951, a complete inventory of the land and forest resources were conducted. In 2001, an intensive forest survey was conducted which encompassed 90% of the tract, detailing the above-ground biomass pools. We’ve used those inventories in conjunction with soil resource data to assemble a carbon balance sheet encompassing the above and belowground carbon pools over the 50 year period. We’ve also employed inventories on forest removals, forest burning and runoff to estimate fluxes from the landscape over the same period. There was a net sequestration of 5,486 Gg of C in forest vegetation over the 50 yr. period (1.5 Mg ha-1 yr-1), with carbon density increasing from 6.3 to 83.3 Mg ha-1. The reforestation of the agricultural land and the increased density of the former woodlots was the cause of the gain. Fifty years after imposition of silvicultural prescriptions, the forest composition has changed from being dominated by hardwoods to pine. The forest floor increased by 311 Gg carbon. Fluxes in form of harvested wood and oxidation from burning were 24% and 10% respectively of the net gain in vegetative biomass. These findings document real changes in carbon storage on a landscape that was changed from mixed agricultural use to managed forests, and they suggest responses that should be similar if reforestation for biofuels production is expanded.

  12. A storm severity index based on return levels of wind speeds

    NASA Astrophysics Data System (ADS)

    Becker, Nico; Nissen, Katrin M.; Ulbrich, Uwe

    2015-04-01

    European windstorms related to extra-tropical cyclones cause considerable damages to infrastructure during the winter season. Leckebusch et al. (2008) introduced a storm severity index (SSI) based on the exceedances of the local 98th percentile of wind speeds. The SSI is based on the assumption that (insured) damage usually occurs within the upper 2%-quantile of the local wind speed distribution (i.e. if the 98th percentile is exceeded). However, critical infrastructure, for example related to the power network or the transportation system, is usually designed to withstand wind speeds reaching the local 50-year return level, which is much higher than the 98th percentile. The aim of this work is to use the 50-year return level to develop a modified SSI, which takes into account only extreme wind speeds relevant to critical infrastructure. As a first step we use the block maxima approach to estimate the spatial distribution of return levels by fitting the generalized extreme value (GEV) distribution to the wind speeds retrieved from different reanalysis products. We show that the spatial distributions of the 50-year return levels derived from different reanalyses agree well within large parts of Europe. The differences between the reanalyses are largely within the range of the uncertainty intervals of the estimated return levels. As a second step the exceedances of the 50-year return level are evaluated and compared to the exceedances of the 98th percentiles for different extreme European windstorms. The areas where the wind speeds exceed the 50-year return level in the reanalysis data do largely agree with the areas where the largest damages were reported, e.g. France in the case of "Lothar" and "Martin" and Central Europe in the case of "Kyrill". Leckebusch, G. C., Renggli, D., & Ulbrich, U. (2008). Development and application of an objective storm severity measure for the Northeast Atlantic region. Meteorologische Zeitschrift, 17(5), 575-587.

  13. Assessment of coastal erosion and quantification of land loss on Western Pacific atolls during the last 50 years

    NASA Astrophysics Data System (ADS)

    Taborosi, Danko; Zega, Mojca; Jenson, John W.

    2010-05-01

    others, and that land is not always eroding but in some cases accreting. We are currently engaged in a systematic survey of islands across the region in order to differentiate local problems from wide-ranging phenomena and gain insight into the temporal and geospatial "big picture." The direct aim is to comprehensively and more precisely assess coastal erosion and quantify changes in land area of different islands over the past 50 years. The project consists of fieldwork and GIS analyses, and it is the first to employ such methods to evaluate shoreline transformation in the western Pacific. We visit each island, interview local people regarding recent land changes and events, and carry out site investigations and mapping. Each inhabited island is circumambulated on foot, and beach slopes and scarps are measured, sediments examined, human activities and vegetation damage noted, etc. More importantly, the entire coast of each island is mapped using MobileMapper PRO portable units capable of generating GIS shapefiles in the field. Created coverages include the actual shoreline, sandy banks, vegetated areas, coastal engineering, control points, etc. Data collected on the ground is imported into ArcGIS and rectified using remote sensing imagery. It is then compared to all available historical maps, notably US Army Corps of Engineers 1960s topographic charts, which were previously assembled, digitized, and georeferenced for the purposes of this project. Any discrepancies in island outline and land area would have occurred over the past half a century. Due to the vastness of western Pacific region and logistical obstacles to working on remote islands, data are accumulated gradually. Ultimately, this island-by-island approach will allow documentation of historical and regional erosion patterns, contribute to understanding of local and global components of recent coastal changes, and deliver recommendations for environmental management and emergency avoidance on atolls and other

  14. Why Do Staff Return?

    ERIC Educational Resources Information Center

    Magnuson, Connie

    1992-01-01

    Surveyed 211 returning staff from 25 camps and interviewed 19 returning staff to study factors that influence a counselor's decision to return to camp. Examined the following dimensions of motivation and hygiene factors: (1) stimulation or inspiration; (2) personal; (3) job-related experience; (4) living conditions and camp life; (5) camp…

  15. Mentoring Literacy Professionals: Continuing the Spirit of CRA/ALER after 50 Years. The Thirty-First Yearbook: A Doubled Peer Reviewed Publication of the College Reading Association

    ERIC Educational Resources Information Center

    Szabo, Susan, Ed.; Sampson, Mary Beth, Ed.; Foote, Martha M., Ed.; Falk-Ross, Francine, Ed.

    2010-01-01

    This volume is a milestone year for the Yearbook, the conference, and the College Reading Association (CRA). At this conference, CRA celebrated its 50th year. The title of this thirty-first yearbook mirrors the theme of the 2008 conference--"Mentoring Literacy Professionals for 50 Years." The title "Mentoring Literacy Professionals: Continuing the…

  16. Trichuris sp. from 1,040 +/- 50-year-old Cervidae coprolites from the archaeological site Furna do Estrago, Pernambuco, Brazil.

    PubMed

    Sianto, Luciana; Duarte, Antônio Nascimento; Chame, Marcia; Magalhães, Juliana; Souza, Mônica Vieira de; Ferreira, Luiz Fernando; Araújo, Adauto

    2012-03-01

    We present results of the paleoparasitological analysis of Cervidae coprolites that were recovered from the archaeological site Furna do Estrago, Pernambuco, Brazil. Trichuris sp. eggs were recovered from the coprolite samples dated 1,040 ± 50 years before present. This is the first record of Trichuris sp. in semiarid Cervidae, unexpectedly recorded in archaeological material. PMID:22415268

  17. "This Is the Beginning of My Life Educationally": Older (50+ Years) Working Class Adults' Participation in Higher Education in Scotland, through the Lens of Critical Educational Gerontology

    ERIC Educational Resources Information Center

    McAllister, Chris

    2010-01-01

    This paper reports on original research where the primary objective was to critically explore the learning experiences of older (50+ years) working class adults in the context of a new university. Semi-structured interviews with 10 older learners engaged in a range of study in a new university in the west of Scotland were utilised. This…

  18. [MSDs and job security of employees aged 50 years and over: a challenge for occupational health and public health].

    PubMed

    Chiron, Elise; Roquelaure, Yves; Ha, Catherine; Touranchet, Annie; Chotard, Anne; Bidron, Patrick; Ledenvic, Béatrice; Leroux, François; Mazoyer, Annick; Goldberg, Marcel; Imbernon, Ellen

    2008-01-01

    Work-related musculoskeletal disorders of the upper limbs (MSDs) are the first cause of occupational illness in France, as in Europe. A pilot network for epidemiological surveillance system of MSDs has been implemented in France's Loire Valley region to assess the prevalence of MSDs and their risk factors in the working population, namely the ageing workforce. The surveillance was based on a network of occupational physicians and used the recommendations of a group of European experts ('Saltsa Criteria document' consensus). Between 2002 and 2004, 3710 men and women (aged 20-59) representative of the regional workforce were randomly selected. Exposure to risk factors of MSDs was evaluated by the use of a self-administered questionnaire which aimed to assess bio-mechanical and psychosocial risk factors. With at least one of the six primary MSDs of the upper limbs having been clinically diagnosed using a rigorous protocol, the prevalence of clinically-diagnosed MSDs was high: about 11% of male and 15% of female workers suffered from at least one of the MSDs studied. After age fifty, about 19% of male and 27% of female workers suffered from at least one MSD and 4% of male and 6% of female workers from at least two disorders. Blue-collar workers were the most affected, regardless of age or gender, followed by office employees. Exposure to MSD risk factors of remained high after age fifty: 77% of male and 72% of female blue-collar workers were exposed to at least two MSD risk factors. The implications for the prevention of MSDs and job security of workers are discussed. The high prevalence of specific MSDs of the upper limb combined with a high exposure to risk factors of MSDs in ageing workers emphasizes the need to implement comprehensive prevention programs in most sectors to reduce the exposure to risk, the prevalence of MSDs and ensure the capacity to keep employees suffering from MSDs working, or at least to quickly return to work after recovery. PMID:18773826

  19. 26 CFR 31.6011(a)-5 - Monthly returns.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... IRS shall make a return for the calendar month in which the notice is received, for each of the prior calendar months in the return period, and for each calendar month afterwards (whether or not wages are paid in any such month) until the employer has filed a final return or is required to make quarterly...

  20. 26 CFR 31.6011(a)-5 - Monthly returns.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... IRS shall make a return for the calendar month in which the notice is received, for each of the prior calendar months in the return period, and for each calendar month afterwards (whether or not wages are paid in any such month) until the employer has filed a final return or is required to make quarterly...

  1. 26 CFR 31.6011(a)-5 - Monthly returns.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... IRS shall make a return for the calendar month in which the notice is received, for each of the prior calendar months in the return period, and for each calendar month afterwards (whether or not wages are paid in any such month) until the employer has filed a final return or is required to make quarterly...

  2. 26 CFR 31.6011(a)-5 - Monthly returns.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... IRS shall make a return for the calendar month in which the notice is received, for each of the prior calendar months in the return period, and for each calendar month afterwards (whether or not wages are paid in any such month) until the employer has filed a final return or is required to make quarterly...

  3. 26 CFR 31.6011(a)-5 - Monthly returns.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... IRS shall make a return for the calendar month in which the notice is received, for each of the prior calendar months in the return period, and for each calendar month afterwards (whether or not wages are paid in any such month) until the employer has filed a final return or is required to make quarterly...

  4. Returning Samples from Enceladus

    NASA Astrophysics Data System (ADS)

    Tsou, P.; Kanik, I.; Brownlee, D.; McKay, C.; Anbar, A.; Glavin, D.; Yano, H.

    2012-12-01

    search for chemical biosignatures to understand the habitability potential of the subsurface ocean of Enceladus [Glavin et al. 2011]. By assessing the chiral excess among different amino acids, identifying chains of amino acids, isolate distinct sequences of these chains and the same for nucleic acids, we can formulate a new set of hypotheses to address some of the key science questions required for investigating the stage of extraterrestrial life at Enceladus beyond the four factors of habitability. Criticality of Analyses - For extraterrestrial organic matter analyses such as chirality and compound-specific isotopes, the repeatable robustness of laboratory measurements is a necessity. These analyses require a series of chemical extraction and derivatization steps prior to analysis that is adapted to the sample and procedures results-driven. The Stardust mission is an excellent example of the challenges in the analysis of organics. Confirmation of the cometary origin of the amino acid glycine from comet Wild 2 was obtained 3 years after the samples were returned to Earth. This long period of laboratory development allowed several modifications to the extraction protocol, multiple analytical techniques and instrumentations. Reference: Tsou et al., Astrobiology, in press 2012. McKay et al. Astrobiology 2008. Waite et al. Nature V 460 I 7254, 2009. Postberg et al. EPSC 642P 2011. Glavin et al., LPSC, #5002, 2011.

  5. Return flux experiment

    NASA Technical Reports Server (NTRS)

    Tveekrem, June L.

    1992-01-01

    All spacecraft emit molecules via outgassing, thruster plumes, vents, etc. The return flux is the portion of those molecules that scatter from the ambient atmosphere and return to the spacecraft. Return flux allows critical spacecraft surfaces to become contaminated even when there is no direct line of sight between the contamination source and the critical surface. Data from the Long Duration Exposure Facility (LDEF) show that contamination of LDEF surfaces could not have come entirely from direct flux. The data suggest significant return flux. Several computer models have been developed to simulate return flux, but the predictions have never been verified in orbit. Large uncertainties in predictions lead to overly conservative spacecraft designs. The purpose of the REturn FLux EXperiment (REFLEX) is to fly a controlled experiment that can be directly compared with predictions from several models.

  6. Assured crew return vehicle

    NASA Technical Reports Server (NTRS)

    Cerimele, Christopher J. (Inventor); Ried, Robert C. (Inventor); Peterson, Wayne L. (Inventor); Zupp, George A., Jr. (Inventor); Stagnaro, Michael J. (Inventor); Ross, Brian P. (Inventor)

    1991-01-01

    A return vehicle is disclosed for use in returning a crew to Earth from low earth orbit in a safe and relatively cost effective manner. The return vehicle comprises a cylindrically-shaped crew compartment attached to the large diameter of a conical heat shield having a spherically rounded nose. On-board inertial navigation and cold gas control systems are used together with a de-orbit propulsion system to effect a landing near a preferred site on the surface of the Earth. State vectors and attitude data are loaded from the attached orbiting craft just prior to separation of the return vehicle.

  7. A 50-year record of NOx and SO2 sources in precipitation in the Northern Rocky Mountains, USA

    PubMed Central

    2011-01-01

    Ice-core samples from Upper Fremont Glacier (UFG), Wyoming, were used as proxy records for the chemical composition of atmospheric deposition. Results of analysis of the ice-core samples for stable isotopes of nitrogen (δ15N, ) and sulfur (δ34S, ), as well as and deposition rates from the late-1940s thru the early-1990s, were used to enhance and extend existing National Atmospheric Deposition Program/National Trends Network (NADP/NTN) data in western Wyoming. The most enriched δ34S value in the UFG ice-core samples coincided with snow deposited during the 1980 eruption of Mt. St. Helens, Washington. The remaining δ34S values were similar to the isotopic composition of coal from southern Wyoming. The δ15N values in ice-core samples representing a similar period of snow deposition were negative, ranging from -5.9 to -3.2 ‰ and all fall within the δ15N values expected from vehicle emissions. Ice-core nitrate and sulfate deposition data reflect the sharply increasing U.S. emissions data from 1950 to the mid-1970s. PMID:21385368

  8. Warmer, deeper, and greener mixed layers in the North Atlantic subpolar gyre over the last 50 years.

    PubMed

    Martinez, Elodie; Raitsos, Dionysios E; Antoine, David

    2016-02-01

    Shifts in global climate resonate in plankton dynamics, biogeochemical cycles, and marine food webs. We studied these linkages in the North Atlantic subpolar gyre (NASG), which hosts extensive phytoplankton blooms. We show that phytoplankton abundance increased since the 1960s in parallel to a deepening of the mixed layer and a strengthening of winds and heat losses from the ocean, as driven by the low frequency of the North Atlantic Oscillation (NAO). In parallel to these bottom-up processes, the top-down control of phytoplankton by copepods decreased over the same time period in the western NASG, following sea surface temperature changes typical of the Atlantic Multi-decadal Oscillation (AMO). While previous studies have hypothesized that climate-driven warming would facilitate seasonal stratification of surface waters and long-term phytoplankton increase in subpolar regions, here we show that deeper mixed layers in the NASG can be warmer and host a higher phytoplankton biomass. These results emphasize that different modes of climate variability regulate bottom-up (NAO control) and top-down (AMO control) forcing on phytoplankton at decadal timescales. As a consequence, different relationships between phytoplankton, zooplankton, and their physical environment appear subject to the disparate temporal scale of the observations (seasonal, interannual, or decadal). The prediction of phytoplankton response to climate change should be built upon what is learnt from observations at the longest timescales. PMID:26386263

  9. A 50-year record of NOxand SO2sources in precipitation in the Northern Rocky Mountains, USA

    USGS Publications Warehouse

    Naftz, D.L.; Schuster, P.F.; Johnson, C.A.

    2011-01-01

    Ice-core samples from Upper Fremont Glacier (UFG), Wyoming, were used as proxy records for the chemical composition of atmospheric deposition. Results of analysis of the ice-core samples for stable isotopes of nitrogen (??15N, NO3-) and sulfur (??34SO42-), as well as NO3- and SO42- deposition rates from the late-1940s thru the early-1990s, were used to enhance and extend existing National Atmospheric Deposition Program/National Trends Network (NADP/NTN) data in western Wyoming. The most enriched ??34S value in the UFG ice-core samples coincided with snow deposited during the 1980 eruption of Mt. St. Helens, Washington. The remaining ??34S values were similar to the isotopic composition of coal from southern Wyoming. The ??15N values in ice-core samples representing a similar period of snow deposition were negative, ranging from -5.9 to -3.2 % and all fall within the ??15N values expected from vehicle emissions. Ice-core nitrate and sulfate deposition data reflect the sharply increasing U.S. emissions data from 1950 to the mid-1970s. ?? 2011 Naftz et al; licensee Chemistry Central Ltd.

  10. Evolution of tinea capitis in the Nanchang area, Southern China: a 50-year survey (1965-2014).

    PubMed

    Zhan, Ping; Geng, Chengfang; Li, Zhihua; Jin, Yun; Jiang, Qing; Tao, Li; Luo, Yunpeng; Xiong, Zhiwei; Wu, Shaoxi; Li, Dongmei; Liu, Weida; de Hoog, G Sybren

    2015-05-01

    Tinea capitis remains a common public health problem worldwide especially in developing areas. Aetiologic agents and clinical pattern vary with geography and history of socioeconomic conditions. Three community surveys and a prospective study were carried out over the past 50 years (1965-2014) in the Qingyunpu District of Nanchang, Southern China. Clinical presentation and spectrum of aetiological agents were monitored to understand the evolution of tinea capitis. In 1965 favus was highly epidemic and Trichophyton schoenleinii presented as the overwhelming aetiological agents of scalp infection in the study area, with a prevalence of 3.41% of the population. During a governmental campaign to eliminate tinea capitis initiated in mid of 1960s, favus was successfully controlled and the prevalence decreased to less than 0.01% in 1977. After that period, clinical presentation and spectrum of fungi changed with social development. Trichophyton schoenleinii was replaced by Trichophyton violaceum and Trichophyton mentagrophytes. Nowadays, the species corresponds with a dominant black dot type of tinea capitis in the Nanchang area. The prevalence of causative agents of tinea capitis is not only related to geography but also to socioeconomic factors. Multiple factors have to be considered for the management for control of this disease. PMID:25756741

  11. Cognitive and Functional Decline among Individuals 50 Years of Age or Older in Cambé, Paraná, Brazil: A Population-Based Study

    PubMed Central

    Cabrera, Marcos Aparecido Sarria; Bortoletto, Maira Aira Sayuri Sakay; de Souza, Regina Kazue Tanno; Prina, Douglas Manuel Carrapeiro; Vieira, Maria Cristina Umpierrez; Silva, Ana Maria Rigo

    2016-01-01

    Aims To identify the frequency of cognitive and functional decline (CFD) among adults 50 years of age and older by a population-based study. Methods Cognitive function was analyzed by the Mini-Mental State Examination, and the functional conditions were based on instrumental activities of daily living (IADL). Cases of CFD included individuals with cognitive decline and 2 or more compromised IADL. Results A total of 693 individuals were studied. The frequency of CFD was 16.3%. A low socioeconomic profile was associated with greater CFD independent of gender, age, education, and presence of depression (OR = 2.46; 95% CI: 1.53-3.97). Conclusions These data show a high frequency of CFD among adults 50 years and older. Individuals with less education and a lower socioeconomic level exhibited poorer cognitive and functional conditions. PMID:27350779

  12. Glacier Area and River Runoff Changes in the Head of Ob River Basins During the Last 50 Years

    NASA Astrophysics Data System (ADS)

    Surazakov, A. B.; Aizen, V. B.; Aizen, E. M.; Nikitin, S. A.; Narojniy, J. K.

    2006-12-01

    The Altai mountains in Siberia define southern periphery of the Asian Arctic Basin, and the Ob River is a major Siberian river fed by fresh water from Altai glaciers. Intensification of glacier melt in the head of Ob River since the middle of 20th century may have a considerable influence on the water resources and hydrological regime of Siberian rivers, and freshwater budget of the Arctic Ocean. In our research we estimated glacier area and runoff changes in the Aktru River basin (34.9 km2, 45% covered by glaciers) in the Central Altai using remote sensing data and in situ glaciological and hydrological observations. The measurements of the glacier mass-balance started in this basin in 1952 as a part of the World Glacier Monitoring Service, however an accurate estimation of the glacier area change in the last two decades have not been accomplished. In our research we used aerial photographs (1952, 1975), Corona (1968) and ASTER (2004) images, and Ground Control Points collected with DGPS in 2005 and 2006 field surveys. Preliminary analysis shows that area of the studied glaciers reduced up to 7% and glacier tongues retreated up to 600 m from 1952 to 2004. The rate of the glacier recession doubled between 1975 and 2004 and the river runoff increased by 30 mm/year at the head of Ob river tributaries fed by snow and glacier melt water. During the period from 1954 to 2004 annual (mainly summer) air temperature increased by 0.1 C° a decade and precipitation (mainly spring and summer) increased by 50 mm at an elevation of 2000 m.

  13. Glacier Shrinkage In The East Pamir Plateau In China During The Last 50 Years As Revealed By Two Times' Inventories

    NASA Astrophysics Data System (ADS)

    Wang, N.; Liu, S.; Xu, J.; Guo, W.

    2013-05-01

    The east Pamir Plateau located in China is the source area of the Kaxigar River, one of the tributary of the Tarim River in southern Xinjiang and a vital river to the social and economic development of Kaxigar City. Glaciers in the region play an important role as for the melting water nourishment and seasonal and decadal regulation to the runoff of the Kaxigar River. Early results indicate that glaciers in the region were in a slight retreat during the early 1960s and 2001 with area reduction by 6.2%. To understand their most recent dynamics of glaciers in the region, we have compiled a new inventory of these glaciers based on Landsat TM/ETM+ images acquired in 2009 without clouds and snow cover in the glacierized mountains. At the same time, we have updated the first glacier inventory by digitizing glacier outlines from topographical maps with modification and verification mostly based on aerial photographs. Our results indicate the total glacier area of 2564km2 in 1962 has become decreased to 2038km2 in 2009, 20.5% smaller than their original total. Small glaciers have experienced higher area reduction rate than that of large glaciers, the 11188 glaciers smaller than 10km2 have lost 27.8% of the total area while those 48 glaciers larger than 10km2 have decreased by 11.3% in area. However, there are 7 glaciers of which 6 glaciers with debris cover showing an advancing trend during the same period with average advance by 470m during 1963 and 2009. Compared with early observation, glacier retreat in the region seems accelerated which may be attributed to regional climate warming.

  14. Comparison of weight loss outcomes 1 year after sleeve gastrectomy and Roux-en-Y gastric bypass in patients aged above 50 years

    PubMed Central

    Praveenraj, Palanivelu; Gomes, Rachel M; Kumar, Saravana; Perumal, Sivalingam; Senthilnathan, Palanisamy; Parthasarathi, Ramakrishnan; Rajapandian, Subbiah; Palanivelu, Chinnusamy

    2016-01-01

    INTRODUCTION: Safe, effective weight loss with resolution of comorbidities has been convincingly demonstrated with bariatric surgery in the aged obese. They, however, lose less weight than younger individuals. It is not known if degree of weight loss is influenced by the choice of bariatric procedure. The aim of this study was to compare the degree of weight loss between laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) in patients above the age of 50 years at 1 year after surgery. MATERIALS AND METHODS: A retrospective analysis was performed of all patients more than 50 years of age who underwent LSG or LRYGB between February 2012 and July 2013 with at least 1 year of follow-up. Data evaluated at 1 year included age, sex, weight, body mass index (BMI), mean operative time, percentage of weight loss and excess weight loss, resolution/remission of diabetes, morbidity and mortality. RESULTS: Of a total of 86 patients, 54 underwent LSG and 32 underwent LRYGB. The mean percentage of excess weight loss at the end of 1 year was 60.19 ± 17.45 % after LSG and 82.76 ± 34.26 % after LRYGB (P = 0.021). One patient developed a sleeve leak after LSG, and 2 developed iron deficiency anaemia after LRYGB. The remission/improvement in diabetes mellitus and biochemistry was similar. CONCLUSION: LRYGB may offer better results than LSG in terms of weight loss in patients over 50 years of age. PMID:27279392

  15. Differences in Reach and Attrition Between Web-Based and Print-Delivered Tailored Interventions Among Adults over 50 Years of Age: Clustered Randomized Trial

    PubMed Central

    Bolman, Catherine; Golsteijn, Rianne Henrica Johanna; De Vries, Hein; Mudde, Aart Nicolaas; van Stralen, Maartje Marieke; Lechner, Lilian

    2012-01-01

    participants of the printed intervention. The dropout rate was significantly higher in the Web-based intervention group (53%) compared to the print-delivered intervention (39%, P<.001). A low intention to be physically active was a strong predictor for dropout within both delivery modes (P<.001). The difference in dropout rate between the Web-based and the printed intervention was not explained by user characteristics. Conclusions The reach of the same tailored physical activity (PA) intervention in a printed or Web-based delivery mode differed between sociodemographic subgroups of participants over 50 years of age. Although the reach of the Web-based intervention is lower, Web-based interventions can be a good channel to reach high-risk populations (lower PA intention and higher BMI). While the dropout rate was significantly higher in the Web-based intervention group, no specific user characteristics explained the difference in dropout rates between the delivery modes. More research is needed to determine what caused the high rate of dropout in the Web-based intervention. Trial Registration Dutch Trial Register (NTR): 2297: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2297 (Archived by WebCite at http://www.webcitation.org/65TkwoESp). PMID:23246790

  16. Climatic change effects on hydro-metereological variables in the Alps: a case study on the upper Arve catchment at Chamonix (France) over the last 50 years

    NASA Astrophysics Data System (ADS)

    Viani, Alessandra; Condom, Thomas; Bacchi, Baldassare; Zin, Isabella; Six, Delphine; Gottardi, Frederic; Rabatel, Antoine; Morin, Samuel

    2016-04-01

    Hydrological changes in partially glaciated catchments are expected under future climate scenarios, with consequences for water availability and management at catchment and regional scales. In order to correctly predict the magnitude of such changes and envisage adaptation and/or mitigation measures against water related hazards, a good understanding of the water cycle dynamics at different spatial and temporal scales is needed. The Upper Arve catchment in Chamonix (202 square kilometers), situated in the French Northern Alps, between the two massifs of Mont Blanc and Aiguilles Rouges, is a perfect case study for evaluating the sensitivity of the alpine water cycle to climate change. It is highly glaciated (32% of the total area in 2012) with three important glaciers: Glacier du Tour, Glacier d'Argentiere and Glacier de la Mer de Glace. Its elevation ranges from 1025 up to 4295 m a.s.l. and the exposure of the ice cover is generally north and east oriented. Long term time-series exist of (i) glacier mass balance, (ii) meteorological (in-situ and reanalyses) and (iii) hydrological data. The objectives of the presented study were: 1 - To characterize the inter-annual regimes of the different climatological and hydrological variables: precipitation, temperature and discharge; 2 - To estimate trends on the previous variables, at different temporal scales (annual and monthly) for different altitudes, and compare them to usually observed values in alpine regions; 3 - To infer from the previous statistical analyses and from a cross-analysis between the different considered variables the catchment's hydrological evolution during the last 50 years. Results showed precipitation, temperature and discharge regimes typical of high mountainous partially glaciated catchments. In the long term period, this catchment is characterized by an evident retreat of glacier. Long term trends over the past five decades show no significant change in the annual amount of precipitation. At the

  17. Lightning return stroke models

    NASA Technical Reports Server (NTRS)

    Lin, Y. T.; Uman, M. A.; Standler, R. B.

    1980-01-01

    We test the two most commonly used lightning return stroke models, Bruce-Golde and transmission line, against subsequent stroke electric and magnetic field wave forms measured simultaneously at near and distant stations and show that these models are inadequate to describe the experimental data. We then propose a new return stroke model that is physically plausible and that yields good approximations to the measured two-station fields. Using the new model, we derive return stroke charge and current statistics for about 100 subsequent strokes.

  18. Return to Bangka Island.

    PubMed

    Spence, J

    2001-07-01

    This article is a return in a couple of ways to one of the most tragic events in the history of Australian military nursing. Firstly, it describes how the evacuation of nurses from Singapore in 1941 led to circumstances that resulted in the massacre or internment of many of those women. Then in 1993, a group of surviving World War II nurses and current serving Australian Army nurses returned to the site of their sorrow. PMID:15129536

  19. Your 50-Year Career Plan

    ERIC Educational Resources Information Center

    Perlmutter, David D.

    2007-01-01

    In this article, the author discusses the meaning and importance of the long-term view in the academic profession. Taking the half-century view of a career allows everyone to conceptualize his/her work as both a solitary venture and a group effort. As your career develops and you build alliances and partnerships with colleagues--and then with…

  20. 50 years of holographic interferometry

    NASA Astrophysics Data System (ADS)

    Stetson, Karl A.

    2015-01-01

    Fifty years ago, Robert L. Powell and I discovered holographic interferometry while working at the Radar Laboratory of the University of Michigan's Institute of Science and Technology. I have worked in this field for this entire time span, watched it grow from an unexplored technology to become a widespread industrial testing method, and I have contributed to these developments. In this paper, I will trace my history in this field from our discovery to my involvement in its theory and applications. I will conclude with a discussion of digital holography, which is currently replacing photographic holography for most research and industrial applications.

  1. Celebrating 50 Years of Laser

    SciTech Connect

    Rebel, Heinigerd

    2010-11-24

    When thinking of an innovation that has truly changed our world, it is the laser. Right after discovery back in 1960, it is immediately propelled to a public star. People loved the mystery around this new kind of light. It was soon recognized as a symbol of our entry into the future: The Laser Age has started. Newspapers speculated about ''death rays'' as new weapons. It did not take long time until it appeared in Science fiction movies. However reality was much more beneficial and even more diverse. This device has managed to exceed the wildest predictions of the early laser pioneers when it comes to its applications. Today lasers are not a weird scientist's toy, but are commonly used in our everyday life.Of course, nothing of that was foreseen in the early 1950s. Important fundamentals of lasers have been laid already in 1917 by Albert Einstein, introducing the Einstein coefficient of stimulated emission, and subsequent experimental work by Rudolf Ladenburg, Willis Lamb, Alfred Kastler and others.

  2. Celebrating 50 Years of Laser

    NASA Astrophysics Data System (ADS)

    Rebel, Heinigerd

    2010-11-01

    When thinking of an innovation that has truly changed our world, it is the laser. Right after discovery back in 1960, it is immediately propelled to a public star. People loved the mystery around this new kind of light. It was soon recognized as a symbol of our entry into the future: The Laser Age has started. Newspapers speculated about ``death rays'' as new weapons. It did not take long time until it appeared in Science fiction movies. However reality was much more beneficial and even more diverse. This device has managed to exceed the wildest predictions of the early laser pioneers when it comes to its applications. Today lasers are not a weird scientist's toy, but are commonly used in our everyday life. Of course, nothing of that was foreseen in the early 1950s. Important fundamentals of lasers have been laid already in 1917 by Albert Einstein, introducing the Einstein coefficient of stimulated emission, and subsequent experimental work by Rudolf Ladenburg, Willis Lamb, Alfred Kastler and others.

  3. Comet nucleus and asteroid sample return missions

    NASA Astrophysics Data System (ADS)

    Melton, Robert G.; Thompson, Roger C.; Starchville, Thomas F., Jr.; Adams, C.; Aldo, A.; Dobson, K.; Flotta, C.; Gagliardino, J.; Lear, M.; McMillan, C.

    During the 1991-92 academic year, the Pennsylvania State University has developed three sample return missions: one to the nucleus of comet Wild 2, one to the asteroid Eros, and one to three asteroids located in the Main Belt. The primary objective of the comet nucleus sample return mission is to rendezvous with a short period comet and acquire a 10 kg sample for return to Earth. Upon rendezvous with the comet, a tethered coring and sampler drill will contact the surface and extract a two-meter core sample from the target site. Before the spacecraft returns to Earth, a monitoring penetrator containing scientific instruments will be deployed for gathering long-term data about the comet. A single asteroid sample return mission to the asteroid 433 Eros (chosen for proximity and launch opportunities) will extract a sample from the asteroid surface for return to Earth. To limit overall mission cost, most of the mission design uses current technologies, except the sampler drill design. The multiple asteroid sample return mission could best be characterized through its use of future technology including an optical communications system, a nuclear power reactor, and a low-thrust propulsion system. A low-thrust trajectory optimization code (QuickTop 2) obtained from the NASA LeRC helped in planning the size of major subsystem components, as well as the trajectory between targets.

  4. Comet nucleus and asteroid sample return missions

    NASA Technical Reports Server (NTRS)

    Melton, Robert G.; Thompson, Roger C.; Starchville, Thomas F., Jr.; Adams, C.; Aldo, A.; Dobson, K.; Flotta, C.; Gagliardino, J.; Lear, M.; Mcmillan, C.

    1992-01-01

    During the 1991-92 academic year, the Pennsylvania State University has developed three sample return missions: one to the nucleus of comet Wild 2, one to the asteroid Eros, and one to three asteroids located in the Main Belt. The primary objective of the comet nucleus sample return mission is to rendezvous with a short period comet and acquire a 10 kg sample for return to Earth. Upon rendezvous with the comet, a tethered coring and sampler drill will contact the surface and extract a two-meter core sample from the target site. Before the spacecraft returns to Earth, a monitoring penetrator containing scientific instruments will be deployed for gathering long-term data about the comet. A single asteroid sample return mission to the asteroid 433 Eros (chosen for proximity and launch opportunities) will extract a sample from the asteroid surface for return to Earth. To limit overall mission cost, most of the mission design uses current technologies, except the sampler drill design. The multiple asteroid sample return mission could best be characterized through its use of future technology including an optical communications system, a nuclear power reactor, and a low-thrust propulsion system. A low-thrust trajectory optimization code (QuickTop 2) obtained from the NASA LeRC helped in planning the size of major subsystem components, as well as the trajectory between targets.

  5. Incidence and Mortality after Proximal Humerus Fractures Over 50 Years of Age in South Korea: National Claim Data from 2008 to 2012

    PubMed Central

    Park, Chanmi; Jang, Sunmee; Lee, Areum; Kim, Ha Young; Lee, Yong Beom; Ha, Yong Chan

    2015-01-01

    Background There has been lack of epidemiology of proximal humerus fracture using nationwide database in Asia. The purpose of this study was to investigate the incidence of proximal humerus fracture and its mortality following proximal humerus fracture in Korean over 50 years of age. Methods The Korean National Health Insurance data were evaluated to determine the incidence and mortality of proximal humerus fracture aged 50 years or older from 2008 through 2012. Results Proximal humerus fracture increased by 40.5% over 5 year of study. The incidence of fracture increased from 104.7/100,000 in 2008 to 124.7/100,000 in 2012 in women and from 45.3/100,000 in 2008 to 52.0/100,000 in 2012 in men, respectively. One year mortality rate after proximal humerus fracture was 8.0% in 2008 and 7.0% in 2012. One year mortality rate were 10.8% for men and 7.0% for women in 2008 and 8.5% for men and 6.4% for women in 2012. Conclusions Our study showed that the proximal humerus fracture in elderly was recently increasing and associated with high mortality in Korea. Considering proximal humerus fracture was associated with an increased risk of associated fractures and an increased mortality risk, public health strategy to prevent the proximal humerus fracture in elderly will be mandatory. PMID:25774360

  6. Elucidating the Linkage Between Changes in Land Use, Atmospheric Mineral Dust Loading, and Precipitation in Central Asia During the Past 50-years

    NASA Astrophysics Data System (ADS)

    Sokolik, I. N.; Tatarskii, V. V.; Razuvaev, V. N.; Knight, R. W.; Enloe, J. G.

    2004-12-01

    It is believed that both land-use/land cover changes and atmospheric mineral dust are among the main factors controlling the precipitation and hydrological cycle. Over the past 50-years Central Asia has been undergoing major human-induced land-use changes that altered the geographical area and intensity of dust sources. Desiccation of the Aral Sea and conversion of the steppe in Kazakhstan to the agriculture fields are just a few examples of occurred land-use changes. Interactions of precipitation with land use changes and atmospheric dust can occur at a variety of scales through a poorly understood series of feedback mechanisms. This study addresses this issue by performing a detailed analysis of empirical data at a variety of spatial and temporal scales. The 50-year daily precipitation observations reported from ground-based stations in Central Asia were analyzed to 1) determine the changes in the precipitation distribution and trends and 2) elucidate the potential linkages between precipitation trends and land use and dust loading changes. Utilizing several statistical techniques, we analyzed the precipitation time series for the individual stations as well as for a subset of the stations considering different time-averaging. Several criteria were used to group the stations to separate those affected by dust transport and/or by same types of land-use changes. The consistency between observed precipitation trends and those predicted by the models will be discussed.

  7. Open-Label Trial of Immunogenicity and Safety of a 13-Valent Pneumococcal Conjugate Vaccine in Adults ≥50 Years of Age in Mexico

    PubMed Central

    Juergens, Christine; Ruiz Palacios, Guillermo M.; Vazquez-Narvaez, Jorge; Enkerlin-Pauwells, Hermann Leo; Sundaraiyer, Vani; Pathirana, Sudam; Kalinina, Elena; Gruber, William C.; Scott, Daniel A.; Schmoele-Thoma, Beate

    2014-01-01

    This open-label multicenter clinical trial conducted in Mexico assessed the immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine (PCV13) in adults ≥50 years of age not previously vaccinated with the 23-valent pneumococcal polysaccharide vaccine (PPSV23). The PCV13 elicited a robust immune response in this study population, as reflected by the magnitude of fold rises in functional antibody levels measured by serotype-specific opsonophagocytic activity (OPA) assays before and 1 month after vaccination. Although the prevaccination OPA geometric mean titers (GMTs) for the majority of the serotypes were significantly lower in the 50- to 64-year age group than those in the ≥65-year age group, the postvaccination immune responses were generally similar. The overall immune responses were higher for the majority of the serotypes in the Mexican study population than those in similar adult study populations who received the PCV13 in Europe and the United States. PCV13 was well tolerated, and there were no vaccine-related serious adverse events. In conclusion, PCV13 is safe and immunogenic when administered to adults ≥50 years of age in Mexico and has the potential to protect against vaccine-type pneumococcal disease. (This study has been registered at ClinicalTrials.gov under registration no. NCT01432262.) PMID:25499011

  8. Returning to School for Higher Returns

    ERIC Educational Resources Information Center

    Park, Seonyoung

    2011-01-01

    On the basis of those respondents in the National Longitudinal Survey of Youth (NLSY) who change jobs with an intervening period of education reinvestment, the conventional assumption of linearity of log wages in years of schooling is strongly rejected: a typical reinvestment for the 1980 through 1993 period is associated with a rise of about 3.5…

  9. 26 CFR 1.6081-1 - Extension of time for filing returns.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... return, information return, statement, or other document, including the taxable year or period thereof... of time for filing any return, declaration, statement, or other document which relates to any tax... return of a DISC (as defined in section 992(a)), as specified in section 6072(b), shall not be...

  10. 26 CFR 1.6081-1 - Extension of time for filing returns.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... return, information return, statement, or other document, including the taxable year or period thereof... of time for filing any return, declaration, statement, or other document which relates to any tax... return of a DISC (as defined in section 992(a)), as specified in section 6072(b), shall not be...

  11. 26 CFR 1.6081-1 - Extension of time for filing returns.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... return, information return, statement, or other document, including the taxable year or period thereof... of time for filing any return, declaration, statement, or other document which relates to any tax... return of a DISC (as defined in section 992(a)), as specified in section 6072(b), shall not be...

  12. 26 CFR 1.6081-1 - Extension of time for filing returns.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... return, information return, statement, or other document, including the taxable year or period thereof... of time for filing any return, declaration, statement, or other document which relates to any tax... return of a DISC (as defined in section 992(a)), as specified in section 6072(b), shall not be...

  13. [Fever in returning travelers].

    PubMed

    Burchard, G

    2014-03-01

    Travel-related illness is most often due to gastrointestinal, febrile, and dermatologic diseases. Fever in a returned traveler demands prompt attention because it may be a manifestation of an infection that could be rapidly progressive and lethal. The approach to the febrile patient should be stepwise and consider travel and exposure history. Malaria is the most common cause of fever in patients returning from Sub-Saharan Africa, whereas dengue is more frequent in travelers from other tropical and subtropical areas. Other serious diseases are typhoid and paratyphoid fever, amebic liver abscess, visceral leishmaniasis, leptospirosis and-rarely-viral hemorrhagic fevers. PMID:24557143

  14. Electrostatic Return of Contaminants

    NASA Technical Reports Server (NTRS)

    Rantanen, R.; Gordon, T.

    2003-01-01

    A Model has been developed capable of calculating the electrostatic return of spacecraft-emitted molecules that are ionized and attracted back to the spacecraft by the spacecraft electric potential on its surfaces. The return of ionized contaminant molecules to charged spacecraft surfaces is very important to all altitudes. It is especially important at geosynchronous and interplanetary environments, since it may be the only mechanism by which contaminants can degrade a surface. This model is applicable to all altitudes and spacecraft geometries. In addition to results of the model will be completed to cover a wide range of potential space systems.

  15. Real-world adjuvant TAC or FEC-D for HER2-negative node-positive breast cancer in women less than 50 years of age

    PubMed Central

    Lupichuk, S.; Tilley, D.; Kostaras, X.; Joy, A.A.

    2016-01-01

    Purpose We compared the efficacy, toxicity, and use of granulocyte colony–stimulating factor (g-csf) with tac (docetaxel–doxorubicin–cyclophosphamide) and fec-d (5-fluorouracil–epirubicin–cyclophosphamide followed by docetaxel) in women less than 50 years of age. Methods The study included all women more than 18 years but less than 50 years of age with her2-negative, node-positive, stage ii or iii breast cancer diagnosed in Alberta between 2008 and 2012 who received tac (n = 198) or fec-d (n = 274). Results The patient groups were well-balanced, except that radiotherapy use was higher in the tac group (91.9% vs. 79.9%, p < 0.001). At a median follow-up of 49.6 months, disease-free survival was 91.4% for tac and 92.0% for fec-d (p = 0.76). Overall survival (os) was 96% with tac and 95.3% with fec-d (p = 0.86).The incidences of grades 3 and 4 toxicities were similar in the two groups (all p > 0.05). Overall, febrile neutropenia (fn) was reported in 11.6% of tac patients and 15.7% of fec-d patients (p = 0.26). However, use of g-csf was higher in the tac group than in the fec-d group (96.4% vs. 71.5%, p < 0.001). Hospitalization for fn was required in 10.5% of tac patients and 13.0% of fec-d patients (p = 0.41). In g-csf–supported and –unsupported patients receiving tac, fn occurred at rates of 11.1% and 33.3% respectively (p = 0.08); in patients receiving the fec portion of fec-d, those proportions were 2.9% and 8.1% respectively (p = 0.24); and in patients receiving docetaxel after fec, the proportions were 4.1% and 17.6% respectively (p < 0.001). Conclusions In women less than 50 years of age receiving adjuvant tac or fec-d, we observed no differences in efficacy or other nonhematologic toxicities. Based on the timing and rates of fn, use of prophylactic g-csf should be routine for the docetaxel-containing portion of treatment; however, prophylactic g-csf could potentially be avoided during the fec portion of fec-d treatment. PMID:27330344

  16. Volatility return intervals analysis of the Japanese market

    NASA Astrophysics Data System (ADS)

    Jung, W.-S.; Wang, F. Z.; Havlin, S.; Kaizoji, T.; Moon, H.-T.; Stanley, H. E.

    2008-03-01

    We investigate scaling and memory effects in return intervals between price volatilities above a certain threshold q for the Japanese stock market using daily and intraday data sets. We find that the distribution of return intervals can be approximated by a scaling function that depends only on the ratio between the return interval τ and its mean <τ>. We also find memory effects such that a large (or small) return interval follows a large (or small) interval by investigating the conditional distribution and mean return interval. The results are similar to previous studies of other markets and indicate that similar statistical features appear in different financial markets. We also compare our results between the period before and after the big crash at the end of 1989. We find that scaling and memory effects of the return intervals show similar features although the statistical properties of the returns are different.

  17. Cirrhosis mortality among former American prisoners of war of World War II and the Korean conflict: results of a 50-year follow-up.

    PubMed

    Page, W F; Miller, R N

    2000-10-01

    In our earlier, 30-year follow-up of American prisoners of war (POWs) of World War II and the Korean conflict, we found evidence of increased cirrhosis mortality. Using federal records, we have now extended our follow-up to 50 years (42 years for Korean conflict veterans) and have used proportional hazards analysis to compare the mortality experience of POWs with that of controls. Compared with their controls, World War II POWs had a 32% higher risk of cirrhosis mortality (statistically significant), and mortality risk was higher in the first 30 years of follow-up and also among those aged 51 years and older. Korean POWs had roughly the same risk of cirrhosis mortality as their controls. Neither self-reported data on alcohol consumption nor supplemental morbidity data satisfactorily explained the differences in risk between POWs and controls, although there was evidence that POWs tended to have higher rates of hepatitis, helminthiasis, and nutritional deprivation. PMID:11050876

  18. A current reader's response to the article of 50 years ago by Karpman, B. (1949): "The principles and methods of objective psychotherapy".

    PubMed

    Luborsky, L

    2000-07-01

    The first aim is to describe the psychotherapy of 1949 in the light of today's psychotherapies. The old psychotherapy is suited to treating severely ill patients. It does not use free association, but rather is focused on current problems. It uses dreams, yet it also uses homework and bibliotherapy. The second aim is to critique the treatment. Consistent with its era. it does not make use of medications, and there is an absence of references to psychotherapy research, which was then just starting. The treatment relies over-heavily on the authority of the therapist. A third aim is to describe the changes in our field in the past 50 years and examine the predictions for the future. Although the treatment is called objective psychotherapy, it does not make use of the most up-to-date means of measuring accuracy of interpretations, such as the Core Conflictual Relationship Theme (CCRT) method and other methods like it. PMID:10902948

  19. Ferruccio Ritossa's scientific legacy 50 years after his discovery of the heat shock response: a new view of biology, a new society, and a new journal.

    PubMed

    De Maio, Antonio; Santoro, M Gabriella; Tanguay, Robert M; Hightower, Lawrence E

    2012-03-01

    The pioneering discovery of the heat shock response by the Italian scientist Ferruccio Ritossa reached maturity this year, 2012. It was 50 years ago that Professor Ritossa, through an extraordinary combination of serendipity, curiosity, knowledge and inspiration, published the first observation that cells could mount very strong transcriptional activity when exposed to elevated temperatures, which was coined the heat shock response. This discovery led to the identification of heat shock proteins, which impact many areas of current biology and medicine, and has created a new avenue for more exciting discoveries. In recognition of the discovery of the heat shock response, Cell Stress Society International (CSSI) awarded Professor Ritossa with the CSSI medallion in October 2010 in Dozza, Italy. This article is based on a session of the Fifth CSSI Congress held in Québec commemorating Professor Ritossa and his discovery. PMID:22252402

  20. Multidrug resistant tuberculosis co-existing with aspergilloma and invasive aspergillosis in a 50 year old diabetic woman: a case report

    PubMed Central

    Kumar, Anita A; Shantha, Ghanshyam Palamaner Subash; Jeyachandran, Vijay; Rajkumar, K; Natesan, Senthilkumar; Srinivasan, Devasena; Joseph, Leena Dennis; Sundaresan, Manjunath; Rajamanickam, Deepan

    2008-01-01

    Aspergilloma and invasive aspergillosis coexisting with multidrug resistant Mycobacterium tuberculosis (MDR-TB) in the same patient is a rare entity. We report a 50 year old South Indian woman, a diabetic, who presented to us with complaints of productive cough and hemoptysis for the past 2 months. She was diagnosed to have pulmonary tuberculosis 2 years ago for which she took irregular treatment. Lung imaging showed features of a thick walled cavity in the right upper lobe with an indwelling aspergilloma. She underwent a right lung upper lobe resection. Biopsy and culture of the resected specimen showed the coexistence of Aspergillus fumigatus and multi-drug resistant Mycobacterium tuberculosis. 2 blood cultures grew Aspergillus fumigatus. She was successfully treated with Voriconazole and anti tuberculous therapy against MDR-TB. PMID:18992166

  1. Morphological and Morphometrical Study of the Human Ossicular Chain: A Review of the Literature and a Meta-Analysis of Experience Over 50 Years

    PubMed Central

    Noussios, George; Chouridis, Pantelis; Kostretzis, Lazaros; Natsis, Konstantinos

    2016-01-01

    The ossicular chain has been known for 500 years and yet there are a small number of morphometrical studies. We reviewed the whole literature that is available online regarding the human ossicular chain from an anatomist perspective and correlated the data from all the papers that showed any relevance. Inclusion and exclusion criteria were developed a priori. A thorough description of all ossicular differences has been made and we present their variations in dimensions trying to associate measurements obtained with race. This research included papers spreading on a horizon of over 50 years of worldwide experience. Statistical analysis revealed that there is a great difference in measurements and the results cannot be sufficiently associated. The explanation of this variation in the measurements obtained might be due to errors in the procedure. We conclude that ossicular chain reveals a great variety, and propose that a measurement protocol for auditory ossicles must be widely performed. PMID:26767074

  2. Sustainable Mars Sample Return

    NASA Technical Reports Server (NTRS)

    Alston, Christie; Hancock, Sean; Laub, Joshua; Perry, Christopher; Ash, Robert

    2011-01-01

    The proposed Mars sample return mission will be completed using natural Martian resources for the majority of its operations. The system uses the following technologies: In-Situ Propellant Production (ISPP), a methane-oxygen propelled Mars Ascent Vehicle (MAV), a carbon dioxide powered hopper, and a hydrogen fueled balloon system (large balloons and small weather balloons). The ISPP system will produce the hydrogen, methane, and oxygen using a Sabatier reactor. a water electrolysis cell, water extracted from the Martian surface, and carbon dioxide extracted from the Martian atmosphere. Indigenous hydrogen will fuel the balloon systems and locally-derived methane and oxygen will fuel the MAV for the return of a 50 kg sample to Earth. The ISPP system will have a production cycle of 800 days and the estimated overall mission length is 1355 days from Earth departure to return to low Earth orbit. Combining these advanced technologies will enable the proposed sample return mission to be executed with reduced initial launch mass and thus be more cost efficient. The successful completion of this mission will serve as the next step in the advancement of Mars exploration technology.

  3. Higher Education Endowments Return

    ERIC Educational Resources Information Center

    Bahlmann, David; Walda, John D.; Sedlacek, Verne O.

    2012-01-01

    A new study of endowments by the National Association of College and University Business Officers (NACUBO) and the Commonfund Institute has brought good news to college and universities: While endowment returns dropped precipitously in fiscal year 2009 as a result of the financial crisis and accompanying slide in equity markets, they climbed to an…

  4. Return to Play

    ERIC Educational Resources Information Center

    Mangan, Marianne

    2013-01-01

    Call it physical activity, call it games, or call it play. Whatever its name, it's a place we all need to return to. In the physical education, recreation, and dance professions, we need to redesign programs to address the need for and want of play that is inherent in all of us.

  5. Diagnostic chest x-rays and breast cancer risk before age 50 years for BRCA1 and BRCA2 mutation carriers

    PubMed Central

    John, Esther M.; McGuire, Valerie; Thomas, Duncan; Haile, Robert; Ozcelik, Hilmi; Milne, Roger L.; Felberg, Anna; West, Dee W.; Miron, Alexander; Knight, Julia A.; Terry, Mary Beth; Daly, Mary; Buys, Saundra S.; Andrulis, Irene L.; Hopper, John L.; Southey, Melissa C.; Giles, Graham G.; Apicella, Carmel; Thorne, Heather; Whittemore, Alice S.

    2013-01-01

    Background The effects of low-dose medical radiation on breast cancer risk are uncertain, and few studies have included genetically susceptible women, such as those who carry germline BRCA1 and BRCA2 mutations. Methods We studied 454 BRCA1 and 273 BRCA2 mutation carriers aged <50 years from three breast cancer family registries in the USA, Canada, and Australia/New Zealand. We estimated breast cancer risk associated with diagnostic chest x-rays by comparing mutation carriers with breast cancer (cases) with those without breast cancer (controls). Exposure to chest x-rays was self-reported. Mammograms were not considered in the analysis. Results After adjusting for known risk factors for breast cancer, the odds ratio (OR) for a history of diagnostic chest x-rays, excluding those for tuberculosis or pneumonia, was 1.16 (95% confidence interval (CI) = 0.64–2.11) for BRCA1 mutations carriers and 1.22 (95% CI=0.62–2.42) for BRCA2 mutations carriers. The OR was statistically elevated for BRCA2 mutation carriers with 3–5 diagnostic chest x-rays (p = 0.01), but not for those with 6 or more chest x-rays. Few women reported chest fluoroscopy for tuberculosis or chest x-rays for pneumonia; the OR estimates were elevated, but not statistically significant, for BRCA1 mutation carriers. Conclusions Our findings do not support a positive association between diagnostic chest x-rays and breast cancer risk before age 50 years for BRCA1 or BRCA2 mutation carriers. Impact Given the increasing use of diagnostic imaging involving higher ionizing radiation doses, further studies of genetically predisposed women are warranted. PMID:23853209

  6. Associations of various perceived-stress situations with depressive symptoms in ≥50-year old Taiwanese men and women: Results from the Taiwan Longitudinal Study on Aging.

    PubMed

    Tsai, Hsin-Jen; Chang, Fu-Kuei

    2016-01-01

    This study was aimed to evaluate the cross-sectional and longitudinal associations between various perceived-stress and depressive symptoms in old Taiwanese men and women aged 50 years and over. Data were derived from the Taiwan Longitudinal Study on Aging. Stress for health, finance, and family members' related issues were all cross-sectionally associated with concurrent depressive symptoms for men and women (all P<0.05). Increased/constant-high health stress was positively associated with subsequent depressive symptoms in both genders (all P<0.05). Constantly high job stress and increased stress over family members' problems were associated with higher likelihood of subsequent depressive symptoms in men (P<0.05). Constantly high/increased financial stress and relationship strain with family members were positively associated with subsequent depressive symptoms in women (all P<0.05). The results suggest that stress for health, job, finance, and family members-related issues are unequally associated with depressive symptoms among Taiwanese men and women aged 50 years and over. Changes of health stress even reduced are significantly associated with subsequent depressive symptoms. Long-term job stress and increased stress over family members' problems increase occurrences of men's depressive symptoms, while increased/long-term financial stress and relationship-strain with family members increase occurrences of women's depressive symptoms. Long-term high health stress has more impacts on men's depressive symptoms than women's, while long-term high relationship strain with family members has more impacts on women's depressive symptoms than men's. PMID:27490720

  7. Vitamin D Deficiency Is Highly Concomitant but Not Strong Risk Factor for Mortality in Patients Aged 50 Year and Older with Hip Fracture

    PubMed Central

    Lee, Gyeong-Hak; Lim, Jung-Won; Park, Yong-Gum

    2015-01-01

    Background The purpose of this study was to ascertain the prevalence of vitamin D deficiency and risk factors associated with mortality in patients ≥50-year-of-age with hip fractures. Methods A total of 489 patients ≥50-year-of-age who sustained a hip fracture from January 2010 to October 2014 were followed-up for a minimum of 1 year. Clinical and radiological outcomes were evaluated including prevalence of vitamin D deficiency. Crude mortality rates were calculated, and the effects of different risk factors on mortality were assessed. Results Vitamin D deficiency was present in 76.5% of cases (n=237). The prevalence of vitamin D insufficiency was 12.3%, and only 11.2% of patients had normal vitamin D levels. Accumulated mortality was 11% (54 patients) at 1 year. A univariate analysis showed that vitamin D deficiency (P=0.012), age (P<0.001), BMI (P<0.001), type of management (P<0.001), American Society of Anesthesiologists (ASA) score (P=0.009), pre-fracture ambulatory status (P<0.001), and osteoporosis (P<0.001) were associated with mortality. A multivariate analysis performed using a Cox proportional hazards model demonstrated that ASA score (P=0.001) and pre-fracture ambulatory status (P=0.011) were independently associated with mortality after hip fracture. Conclusions We did not find a relationship between serum 25-hydroxy-vitamin D levels and mortality after hip fracture, although we observed a high prevalence of vitamin D deficiency and a significant association with mortality in the univariate analysis. PMID:26713312

  8. Failure to Return for Posttest Counseling and HIV Test Results at the Prevention and Voluntary Testing and Counseling Centers of Douala, Cameroon: An Evaluation of a Routine Five-Year Program

    PubMed Central

    Ngangue, Patrice; Bedard, Emmanuelle; Ngueta, Gerard; Adiogo, Dieudonné; Gagnon, Marie-Pierre

    2016-01-01

    This study examined the magnitude and time trends in failure to return (FTR) rates and the relation between FTR and individual characteristics, tests procedures, waiting period for the results, and HIV test results among people who were screened for HIV in the prevention and voluntary testing and counseling centers (PVTCCs) of six district hospitals of the city of Douala in Cameroon, between January 2009 and December 2013. It was a retrospective analysis of medical records. Among the 32,020 analyzed records, the failure to return (FTR) rate was 14.3%. Overall, people aged 50 years and over, those tested between 2011 and 2012, and those tested in the PVTCC of Bonassama were less likely to return for their results. Significant factors associated with FTR included being a housewife, having a positive/undetermined/requiring confirmation result, and provider-initiated testing and counseling (PITC). There was an increasing trend for FTR in the PVTCCs of Bonassama, New-Bell, Nylon, and Cité des Palmiers. HIV testing and counseling services in Douala district hospitals must be reorganized such that individuals tested for HIV receive their results on the same day of the test. Also counselors need to better alert clients concerning the importance of returning for their test results. PMID:26925261

  9. Phobos Sample Return mission

    NASA Astrophysics Data System (ADS)

    Zelenyi, Lev; Zakharov, A.; Martynov, M.; Polischuk, G.

    Very mysterious objects of the Solar system are the Martian satellites, Phobos and Deimos. Attempt to study Phobos in situ from an orbiter and from landers have been done by the Russian mission FOBOS in 1988. However, due to a malfunction of the onboard control system the landers have not been delivered to the Phobos surface. A new robotics mission to Phobos is under development now in Russia. Its main goal is the delivery of samples of the Phobos surface material to the Earth for laboratory studies of its chemical, isotopic, mineral composition, age etc. Other goals are in situ studies of Phobos (regolith, internal structure, peculiarities in orbital and proper rotation), studies of Martian environment (dust, plasma, fields). The payload includes a number of scientific instruments: gamma and neutron spectrometers, gaschromatograph, mass spectrometers, IR spectrometer, seismometer, panoramic camera, dust sensor, plasma package. To implement the tasks of this mission a cruise-transfer spacecraft after the launch and the Earth-Mars interplanetary flight will be inserted into the first elliptical orbit around Mars, then after several corrections the spacecraft orbit will be formed very close to the Phobos orbit to keep the synchronous orbiting with Phobos. Then the spacecraft will encounter with Phobos and will land at the surface. After the landing the sampling device of the spacecraft will collect several samples of the Phobos regolith and will load these samples into the return capsule mounted at the returned vehicle. This returned vehicle will be launched from the mother spacecraft and after the Mars-Earth interplanetary flight after 11 monthes with reach the terrestrial atmosphere. Before entering into the atmosphere the returned capsule will be separated from the returned vehicle and will hopefully land at the Earth surface. The mother spacecraft at the Phobos surface carrying onboard scientific instruments will implement the "in situ" experiments during an year

  10. Changing Returns to Education in Spain During the 1980s.

    ERIC Educational Resources Information Center

    Vila, Luis-Eduardo; Mora, Jose-Gines

    1998-01-01

    Presents evidence on returns to education for Spanish employees during the 1980s, a period of remarkable structural transformation. Results show a declining payoff to education between 1981 and 1991 for lower and intermediate educational levels. Higher education does not show a reduction in return. Earnings inequality by gender declined noticeably…

  11. 29 CFR 825.311 - Intent to return to work.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Intent to return to work. 825.311 Section 825.311 Labor... AND MEDICAL LEAVE ACT OF 1993 Employee and Employer Rights and Obligations Under the Act § 825.311 Intent to return to work. (a) An employer may require an employee on FMLA leave to report periodically...

  12. Components of multifractality in high-frequency stock returns

    NASA Astrophysics Data System (ADS)

    Kwapień, J.; Oświeçimka, P.; Drożdż, S.

    2005-05-01

    We analyzed multifractal properties of 5-min stock returns from a period of over two years for 100 highly capitalized American companies. The two sources: fat-tailed probability distributions and non-linear temporal correlations, vitally contribute to the observed multifractal dynamics of the returns. For majority of the companies the temporal correlations constitute a much more significant related factor, however.

  13. Assured Crew Return Vehicle

    NASA Technical Reports Server (NTRS)

    Stone, D. A.; Craig, J. W.; Drone, B.; Gerlach, R. H.; Williams, R. J.

    1991-01-01

    The developmental status is discussed regarding the 'lifeboat' vehicle to enhance the safety of the crew on the Space Station Freedom (SSF). NASA's Assured Crew Return Vehicle (ACRV) is intended to provide a means for returning the SSF crew to earth at all times. The 'lifeboat' philosophy is the key to managing the development of the ACRV which further depends on matrixed support and total quality management for implementation. The risk of SSF mission scenarios are related to selected ACRV mission requirements, and the system and vehicle designs are related to these precepts. Four possible ACRV configurations are mentioned including the lifting-body, Apollo shape, Discoverer shape, and a new lift-to-drag concept. The SCRAM design concept is discussed in detail with attention to the 'lifeboat' philosophy and requirements for implementation.

  14. Measurements of Cosmogenic Nuclides in and their Significance for Samples Returned from Asteroids

    NASA Technical Reports Server (NTRS)

    Nishiizumi, K.; Herzog, G. F.; Reedy, R. C.

    2000-01-01

    Nuclear interactions of cosmic rays with matter produce cosmogenic nuclides (CNs). Ever since they were first measured nearly 50 years ago, cosmogenic nuclides have been used to infer the irradiation histories of terrestrial and extraterrestrial materials. Here we call for an extension of such measurements to samples returned from an asteroidal surface. The information gained in this way will be important for elucidating the evolution of the asteroidal surface. Additional information is contained in the original extended abstract.

  15. Dairy Intake Enhances Body Weight and Composition Changes during Energy Restriction in 18–50-Year-Old Adults—A Meta-Analysis of Randomized Controlled Trials

    PubMed Central

    Stonehouse, Welma; Wycherley, Thomas; Luscombe-Marsh, Natalie; Taylor, Pennie; Brinkworth, Grant; Riley, Malcolm

    2016-01-01

    Background/Aims: A meta-analysis of randomized controlled trials (RCTs) was performed to investigate the effects of dairy food or supplements during energy restriction on body weight and composition in 18–50-year-old. Methods: RCTs ≥ 4 weeks comparing the effect of dairy consumption (whole food or supplements) with control diets lower in dairy during energy restriction on body weight, fat and lean mass were identified by searching MEDLINE, EMBASE, Pubmed, Cochrane Central and World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) until March 2016. Reports were identified and critically appraised in duplicate. Data were pooled using random-effects meta-analysis. Chi2- and I2-statistics indicated heterogeneity. Dose effect was assessed using meta-regression analysis. GRADE guidelines were used to rate the quality (QR) of the evidence considering risk of bias, inconsistency, indirectness, imprecision, publication bias and effect estimates. Results: 27 RCTs were reviewed. Participants consumed between 2 and 4 standard servings/day of dairy food or 20–84 g/day of whey protein compared to low dairy control diets, over a median of 16 weeks. A greater reduction in body weight (−1.16 kg [−1.66, −0.66 kg], p < 0.001, I2 = 11%, QR = high, n = 644) and body fat mass (−1.49 kg [−2.06, −0.92 kg], p < 0.001, I2 = 21%, n = 521, QR = high) were found in studies largely including women (90% women). These effects were absent in studies that imposed resistance training (QR = low-moderate). Dairy intake resulted in smaller loss of lean mass (all trials pooled: 0.36 kg [0.01, 0.71 kg], p = 0.04, I2 = 64%, n = 651, QR = moderate). No between study dose-response effects were seen. Conclusions: Increased dairy intake as part of energy restricted diets resulted in greater loss in bodyweight and fat mass while attenuating lean mass loss in 18–50-year-old adults. Further research in males is needed to investigate sex effects. PMID:27376321

  16. Problem Periods

    MedlinePlus

    ... gov/ Home Body Getting your period Problem periods Problem periods It’s common to have cramps or feel ... doctor Some common period problems Signs of period problems top One way to know if you may ...

  17. Long-term outcome of 73 Zweymüller total hip prostheses with a screw cup in patients under 50 years of age.

    PubMed

    Busch, Vincentius J J F; Pouw, Martin H; Laumen, Armand M R P; van Susante, Job L C; Vervest, Antonius M J S

    2012-01-01

    Total hip arthroplasty in young patients is associated with high failure rates and the best option for this demanding group of patients remains controversial. We report the long-term results of 73 consecutive Zweymüller total hip arthroplasties with a titanium threaded cup and a polyethylene insert in 67 patients aged under 50 years at the time of surgery (mean 43 years, range 23-49). Independent assessment was performed clinically and radiographically, and Kaplan-Meier analysis was used to determine survival for different end-points. Three hips were revised for septic loosening, three cups for aseptic loosening and one hip because of a periprosthetic fracture. Three patients (3 hips) died and seven patients (8 hips) were lost to radiographic follow-up without any reoperation. The mean follow-up was 17.5 (15-21) years and the mean HHS was 90 (52-100). Survival with an end-point of revision for any reason was 89% (95% C.I. 85-93) and of revision for aseptic loosening was 94% (C.I. 95-99) at 17 years. Zweymüller total hip arthroplasty with a titanium threaded cup and a polyethylene insert showed good long-term results, even in this group of young patients. PMID:22740279

  18. Long space missions, gene therapy, and the vital role of magnesium: a three-pronged plan for the next 50 years

    PubMed Central

    Rowe, William J

    2010-01-01

    Since pharmaceuticals cannot be used in space until liver and kidney dysfunctions are corrected, and with invariable malabsorption, it appears there is no alternative other than to use subcutaneous magnesium (Mg) replacements in the presence of deficiencies and use of gene therapy. I suggest beginning with the correction of as many as four gene deficiencies: atrial natriuretic peptide (ANP), nitric oxide (NO), vascular endothelial growth factor (VEGF), and erythropoietin (EPO), all as well as Mg related to perfusion and angiogenesis. There is no evidence of significant lunar radiation levels in the absence of a solar storm. It could then be determined whether this has resulted in correction of liver and kidney dysfunction. If this persists, serial additions of gene therapy will be required determining the effect of each individual gene trial on organ function. Microgravity and endothelial gaps with leaks trigger reduced plasma volume. Partial correction by use of a plasma volume substitute and development of a delivery device may reduce complexity of gene therapy. Research would be conducted both on Earth and in microgravity, with the development of subcutaneous pharmaceuticals and Mg, and a space walk-reliable subcutaneous silicon device, given that no replenishable subcutaneous device is presently available. A three-pronged approach provides a plan for the next 50 years: A. complete correction of a Mg deficit; B. partial replacement with plasma volume substitutes, and C. multiple gene factor strategy. PMID:21694938

  19. Development of numerical models for injury biomechanics research: a review of 50 years of publications in the Stapp Car Crash Conference.

    PubMed

    Yang, King H; Hu, Jingwen; White, Nicholas A; King, Albert I; Chou, Clifford C; Prasad, Priya

    2006-11-01

    Numerical analyses frequently accompany experimental investigations that study injury biomechanics and improvements in automotive safety. Limited by computational speed, earlier mathematical models tended to simplify the system under study so that a set of differential equations could be written and solved. Advances in computing technology and analysis software have enabled the development of many sophisticated models that have the potential to provide a more comprehensive understanding of human impact response, injury mechanisms, and tolerance. In this article, 50 years of publications on numerical modeling published in the Stapp Car Crash Conference Proceedings and Journal were reviewed. These models were based on: (a) author-developed equations and software, (b) public and commercially available programs to solve rigid body dynamic models (such as MVMA2D, CAL3D or ATB, and MADYMO), and (c) finite element models. A clear trend that can be observed is the increasing use of the finite element method for model development. A review of these modeling papers clearly indicates the progression of the state-of-the-art in computational methods and technologies in injury biomechanics. PMID:17311173

  20. [Carbon monoxide poisoning: clinical features of the victims of the explosion accident of Mitsui-Miike Mikawa coal mine 50 years ago].

    PubMed

    Kato, Motohiro

    2015-01-01

    Clinical features of carbon monoxide poisoning have been described in 24 victims of an intense explosion accident of the Mitsui-Miike Mikawa coal mine in Japan 50 years ago; these victims were admitted to the Kyushu University Hospital as they suffered from severe poisoning. In the early stage of poisoning, all victims showed disturbed state of consciousness, varying in duration from 5.5 hours to 3 months, and the duration of unconsciousness was closely correlated to the clinical severity in the late stage. Some of the severely poisoned patients showed a transient stage of apallic syndrome. After recovery from unconsciousness, all patients presented with severe amnestic syndrome and loss of initiative. Neurologically, the extrapyramidal signs were prominent in the early stage, which gradually improved in the late stage. Variable types of agnosia and apraxia were apparent in some of the severely and moderately poisoned patients in the late stage, with prominent Gerstmann syndrome and visual-visuospatial agnosias. Since these signs showed poor improvement, the agnosia and apraxia, as well as impaired intellectual ability, remained as a sequela of the poisoning, and were one of the major causes of deficits of the patients in their daily life activities in the late stage. PMID:25585432

  1. The "CEO" of women's work lives: how Big Five Conscientiousness, Extraversion, and Openness predict 50 years of work experiences in a changing sociocultural context.

    PubMed

    George, Linda G; Helson, Ravenna; John, Oliver P

    2011-10-01

    Few long-term longitudinal studies have examined how dimensions of personality are related to work lives, especially in women. We propose a life-course framework for studying work over time, from preparatory activities (in the 20s) to descending work involvement (after age 60), using 50 years of life data from the women in the Mills Longitudinal Study. We hypothesized differential work effects for Extraversion (work as pursuit of rewards), Openness (work as self-actualization), and Conscientiousness (work as duty) and measured these 3 traits as predictor variables when the women were still in college. In a prospective longitudinal design, we then studied how these traits predicted the women's subsequent work lives from young adulthood to age 70 and how these effects depended on the changing sociocultural context. Specifically, the young adulthood of the Mills women in the mid-1960s was rigidly gender typed and family oriented; neither work nor education variables at that time were predicted from earlier personality traits. However, as women's roles changed, later work variables became related to all 3 traits, as expected from current Big Five theory and research. For example, early personality traits predicted the timing of involvement in work, the kinds of jobs chosen, and the status and satisfaction achieved, as well as continued work participation and financial security in late adulthood. Early traits were also linked to specific cultural influences, such as the traditional feminine role, the women's movement, and graduate education for careers. PMID:21859225

  2. The Association between the Consumption of Fish/Shellfish and the Risk of Osteoporosis in Men and Postmenopausal Women Aged 50 Years or Older

    PubMed Central

    Choi, Eunjin; Park, Youngsoon

    2016-01-01

    Fish rich in n-3 polyunsaturated fatty acids have been suggested to have a favorable effect on bone health, but previous epidemiologic studies have shown inconsistent results. The purpose of the present study was to investigate the hypothesis that the consumption of fish and shellfish is positively associated with bone mass and negatively associated with the risk of osteoporosis in Koreans and Americans. Men and postmenopausal women ≥50 years old from the Korean National Health and Nutrition Examination Survey 2008–2011 (n = 7154) and the National Health and Nutrition Examination Survey 2007–2010 (n = 2658) were included. There was a positive correlation between the consumption of fish and shellfish and bone mineral density (BMD) of the total femur, femoral neck, and lumbar spine in Koreans. Consistently, multivariate logistic regression analysis showed a significant association between intake of fish and shellfish and the risk of osteoporosis in Koreans but not in Americans. Consumption of fish and shellfish was 4–5 times higher in Koreans than Americans in the present study. In conclusion, intake of fish and shellfish was associated with BMD and the risk of osteoporosis in Koreans but not in Americans, suggesting that a minimum intake level of fish and shellfish might be recommended to protect against bone loss and osteoporosis. PMID:26927165

  3. Novel mutations in the VKORC1 gene of wild rats and mice – a response to 50 years of selection pressure by warfarin?

    PubMed Central

    Rost, Simone; Pelz, Hans-Joachim; Menzel, Sandra; MacNicoll, Alan D; León, Vanina; Song, Ki-Joon; Jäkel, Thomas; Oldenburg, Johannes; Müller, Clemens R

    2009-01-01

    Background Coumarin derivatives have been in world-wide use for rodent pest control for more than 50 years. Due to their retarded action as inhibitors of blood coagulation by repression of the vitamin K reductase (VKOR) activity, they are the rodenticides of choice against several species. Resistance to these compounds has been reported for rodent populations from many countries around the world and poses a considerable problem for efficacy of pest control. Results In the present study, we have sequenced the VKORC1 genes of more than 250 rats and mice trapped in anticoagulant-exposed areas from four continents, and identified 18 novel and five published missense mutations, as well as eight neutral sequence variants, in a total of 178 animals. Mutagenesis in VKORC1 cDNA constructs and their recombinant expression revealed that these mutations reduced VKOR activities as compared to the wild-type protein. However, the in vitro enzyme assay used was not suited to convincingly demonstrate the warfarin resistance of all mutant proteins Conclusion Our results corroborate the VKORC1 gene as the main target for spontaneous mutations conferring warfarin resistance. The mechanism(s) of how mutations in the VKORC1 gene mediate insensitivity to coumarins in vivo has still to be elucidated. PMID:19200363

  4. Mortgage Delinquency and Changes in Access to Health Resources and Depressive Symptoms in a Nationally Representative Cohort of Americans Older Than 50 Years

    PubMed Central

    Lloyd, Jennifer; Pagán, José A.; Pollack, Craig E.; Shardell, Michelle; Cannuscio, Carolyn

    2011-01-01

    Objectives. We evaluated associations between mortgage delinquency and changes in health and health-relevant resources over 2 years, with data from the Health and Retirement Study, a longitudinal survey representative of US adults older than 50 years. Methods. In 2008, participants reported whether they had fallen behind on mortgage payments since 2006 (n = 2474). We used logistic regression to compare changes in health (incidence of elevated depressive symptoms, major declines in self-rated health) and access to health-relevant resources (food, prescription medications) between participants who fell behind on their mortgage payments and those who did not. Results. Compared with nondelinquent participants, the mortgage-delinquent group had worse health status and less access to health-relevant resources at baseline. They were also significantly more likely to develop incident depressive symptoms (odds ratio [OR] = 8.60; 95% confidence interval [CI] = 3.38, 21.85), food insecurity (OR = 7.53; 95% CI = 3.01, 18.84), and cost-related medication nonadherence (OR = 8.66; 95% CI = 3.72, 20.16) during follow-up. Conclusions. Mortgage delinquency was associated with significant elevations in the incidence of mental health impairments and health-relevant material disadvantage. Widespread mortgage default may have important public health implications. PMID:22021301

  5. [The changes in values and beliefs through the first 50 years of the department of Psychiatry at the University of Montreal].

    PubMed

    Borgeat, François; Dongier, Maurice

    2015-01-01

    This essay attempts to describe and discuss the major changes in values and fundamental beliefs related to clinical practice within the Département de psychiatrie de l'Université de Montréal since its creation fifty years ago.Being an essay, the methods include shared recollections, discussions with colleagues, especially between the co-authors, and the study of some documents related to the practice of psychiatry 40 to 50 years ago.Five major axes of change are proposed: 1- From psychoanalysis to brain diseases, 2- From "Can a non-physician practice psychoanalysis?" to "Can a psychiatrist still perform psychotherapy?" 3- From continuity of care to episodes of treatment, 4- From treatment first to repeated assessments of patients, 5- From love that can heal and repair to a taboo of love.Finally it is suggested that the increasing emphasis on psychopharmacology and on DSM classifications has contributed to a shift from attempts to understand the intimate nature of symptoms and suffering to a priority given to rather mechanical clinical assessments in search of "objective" criteria. PMID:26559213

  6. Returns to Education in Bangladesh

    ERIC Educational Resources Information Center

    Asadullah, Mohammad Niaz

    2006-01-01

    This paper reports labour market returns to education in Bangladesh using data from recent nationwide household survey. Returns are estimated separately for rural and urban samples, males, females and private-sector employees. Substantial heterogeneity in returns is observed; for example, estimates are higher for urban (than rural sample) and…

  7. Energy Vs. Productivity: Diminishing Returns

    ERIC Educational Resources Information Center

    MOSAIC, 1975

    1975-01-01

    Energy invested in corn production is compared with food energy returned in calculations by David Pimentel at Cornell University. The rate of return is falling off sharply in this already energy-intensive agriculture. Increased energy input, in the form of fertilizer, would yield far greater returns where agriculture is less sophisticated.…

  8. A Look at Returning Teachers

    ERIC Educational Resources Information Center

    DeAngelis, Karen J.

    2013-01-01

    Research shows that one-quarter to one-third of teachers who leave the profession return, the majority after only a short absence. Though returning teachers can constitute a substantial share of newly hired teachers in schools each year, little is known about them, the factors associated with their decisions to return, or the schools to which…

  9. Puerto Rican Return Migrant Youth.

    ERIC Educational Resources Information Center

    Carrasquillo, Angela; Carrasquillo, Ceferino

    Among Puerto Ricans who have migrated to the United States, a significant number have returned to Puerto Rico, while others shuttle between Puerto Rico and the United States. These groups of people are identified as return migrants. Studies suggest that return migrant youth in Puerto Rico have had to make environmental and cultural adjustments…

  10. Sample Return Science

    NASA Astrophysics Data System (ADS)

    Williford, K. H.; Allwood, A.; Beegle, L. W.; Bhartia, R.; Flannery, D.; Hoffmann, A.; Mora, M. F.; Orbay, J.; Petrizzo, D. A.; Tuite, M. L., Jr.; Willis, P. A.

    2014-12-01

    The first clear identification of an ancient habitable environment on Mars by the Mars Science Laboratory (MSL) rover mission relied on a synthetic analytical approach combining orbital and surface imagery and spectroscopy with sophisticated sample acquisition and handling technology including a rotary percussive drill that provided powdered rock for bulk geochemical analysis [1]. The recent announcement of the instrument package for the proposed NASA Mars2020 rover mission, including micro x-ray fluorescence (PIXL) for elemental mapping as well as scanning ultraviolet laser fluorescence and Raman (SHERLOC) suggests a shift in emphasis of Mars surface science towards spatially resolved geochemical analysis that will support the selection and acquisition of samples for coring, caching, and possible return to Earth for further analysis. During a recent field expedition to investigate Archean and Proterozoic biosignatures in the Pilbara region of Western Australia, we deployed a dry, rotary percussive coring drill with a bit assembly analogous to that being considered for Mars2020. Six targets of varying age and lithology were sampled with the coring drill, and surrounding and adjacent rock samples were collected simultaneously. These samples were subsequently prepared and subsampled for bulk and in situ, spatially resolved analysis using conventional laboratory methods as well as the existing PIXL and SHERLOC platforms currently in development. Here we present new approaches and data from this integrated and ongoing program of "sample return science" designed to simulate, and eventually reduce risk associated with a long-term effort towards Mars sample return. [1] Grotzinger, J.P. et al. 2014. Science 343 DOI: 10.1126/science.1242777.

  11. Mars sample return - Science

    NASA Technical Reports Server (NTRS)

    Blanchard, Douglas P.

    1988-01-01

    The possible scientific goals of a Mars sample return mission are reviewed, including the value of samples and the selection of sampling sites. The fundamental questions about Mars which could be studied using samples are examined, including planetary formation, differentiation, volcanism and petrogenesis, weathering, and erosion. Scenarios are presented for sample acquisition and analysis. Possible sampling methods and tools are discussed, including drilling techniques, types of rovers, and processing instruments. In addition, the possibility of aerocapture out of elliptical or circular orbit is considered.

  12. Titan Science Return Quantification

    NASA Technical Reports Server (NTRS)

    Weisbin, Charles R.; Lincoln, William

    2014-01-01

    Each proposal for a NASA mission concept includes a Science Traceability Matrix (STM), intended to show that what is being proposed would contribute to satisfying one or more of the agency's top-level science goals. But the information traditionally provided cannot be used directly to quantitatively compare anticipated science return. We added numerical elements to NASA's STM and developed a software tool to process the data. We then applied this methodology to evaluate a group of competing concepts for a proposed mission to Saturn's moon, Titan.

  13. Mortality and cancer registration experience of the Sellafield workers known to have been involved in the 1957 Windscale accident: 50 year follow-up.

    PubMed

    McGeoghegan, D; Whaley, S; Binks, K; Gillies, M; Thompson, K; McElvenny, D M

    2010-09-01

    This paper studies the mortality and cancer morbidity of the 470 male workers involved in tackling the 1957 Sellafield Windscale fire or its subsequent clean-up. Workers were followed up for 50 years to 2007, extending the follow-up of a previously published cohort study on the Windscale fire by 10 years. The size of the study population is small, but the cohort is of interest because of the involvement of the workers in the accident. Significant excesses of deaths from diseases of the circulatory system (standardised mortality ratio (SMR) = 120, 95% CI = 103-138; 194 deaths) driven by ischaemic heart disease (IHD) (SMR = 133, 95% CI = 112-157, 141 deaths) were found when compared with the population of England and Wales but not when compared with the population of Northwest England (SMR = 105, 95% CI = 90-120 and SMR = 115, 95% CI = 97-136 respectively). When compared with those workers in post at the time of the fire but not directly involved in the fire the mortality rate from IHD among those involved in tackling the fire was raised but not statistically significantly (rate ratio (RR) = 1.11, 95% CI = 0.92-1.33). A RR of 1.11 is consistent with an excess relative risk of 0.65 Sv(-1) as reported in an earlier study of non-cancer mortality in the British Nuclear Fuels plc cohort of which these workers are a small but significant part. There was a statistically significant difference in lung cancer mortality (RR = 2.18, 95% CI = 1.05-4.52) rates between workers who had received higher recorded external doses during the fire and those who had received lower external doses. Comparison of the mortality rates of workers directly involved in the accident with workers in post, but not so involved, showed no significant differences overall. On the basis of the use of a propensity score the average effect of involvement in the Windscale fire on all causes of death was - 2.13% (se = 3.64%, p = 0.56) though this difference is not statistically significant. The average effect

  14. Association between Frailty, Osteoporosis, Falls and Hip Fractures among Community-Dwelling People Aged 50 Years and Older in Taiwan: Results from I-Lan Longitudinal Aging Study

    PubMed Central

    Liu, Li-Kuo; Lee, Wei-Ju; Chen, Liang-Yu; Hwang, An-Chun; Lin, Ming-Hsien; Peng, Li-Ning; Chen, Liang-Kung

    2015-01-01

    Background Association of frailty with adverse clinical outcomes has been reported in Western countries, but data from the Asian population are scarce. This study aimed to evaluate the epidemiology of frailty among community-dwelling middle-aged and elderly population and to explore its association with musculoskeletal health in Taiwan. Methods I-Lan Longitudinal Aging Study (ILAS) data were retrieved for this study. Frailty was defined by the Fried’s criteria; a comparison of demographic characteristics, physical performance, and body composition, including skeletal muscle mass and bone mineral density (BMD), as well as recent falls, history of hip fractures and the functional status of subjects with different frailty statuses were accomplished. Results Overall, the data of 1,839 participants (mean age: 63.9±9.3 years, male 47.5%) were obtained for analysis. The prevalence of pre-frailty was 42.3% in men and 38.8% in women, whereas the prevalence of frailty was 6.9% and 6.7% in men and women, respectively. Frailty was significantly associated with older age, the male gender, larger waist circumference, lower skeletal muscle index, lower hip BMD, poorer physical function, poorer nutritional status, and poorer cognitive function. Also, frailty was significantly associated with osteoporosis (OR: 7.73, 95% CI: 5.01–11.90, p<0.001), history of hip fractures (OR: 8.66, 95% CI: 2.47–30.40, p = 0.001), and recent falls (O.R: 2.53, 95% CI: 1.35–4.76, p = 0.004). Conclusions Frailty and pre-frailty, in Taiwan, was closely associated with recent falls, history of hip fractures and osteoporosis among community-dwelling people 50 years of age and older. Furthermore, frailty intervention programs should take an integrated approach towards strengthening both and muscle mass, as well as prevention of falls. PMID:26348034

  15. Assessment of universal health coverage for adults aged 50 years or older with chronic illness in six middle-income countries

    PubMed Central

    Frenz, Patricia; Grabenhenrich, Linus; Keil, Thomas; Tinnemann, Peter

    2016-01-01

    Abstract Objective To assess universal health coverage for adults aged 50 years or older with chronic illness in China, Ghana, India, Mexico, the Russian Federation and South Africa. Methods We obtained data on 16 631 participants aged 50 years or older who had at least one diagnosed chronic condition from the World Health Organization Study on Global Ageing and Adult Health. Access to basic chronic care and financial hardship were assessed and the influence of health insurance and rural or urban residence was determined by logistic regression analysis. Findings The weighted proportion of participants with access to basic chronic care ranged from 20.6% in Mexico to 47.6% in South Africa. Access rates were unequally distributed and disadvantaged poor people, except in South Africa where primary health care is free to all. Rural residence did not affect access. The proportion with catastrophic out-of-pocket expenditure for the last outpatient visit ranged from 14.5% in China to 54.8% in Ghana. Financial hardship was more common among the poor in most countries but affected all income groups. Health insurance generally increased access to care but gave insufficient protection against financial hardship. Conclusion No country provided access to basic chronic care for more than half of the participants with chronic illness. The poor were less likely to receive care and more likely to face financial hardship in most countries. However, inequity of access was not fully determined by the level of economic development or insurance coverage. Future health reforms should aim to improve service quality and increase democratic oversight of health care. PMID:27034521

  16. The Archiv für Ohrenheilkunde (Archive of Otology): a structural analysis of the first 50 years (1864-1914).

    PubMed

    Peinhardt, Juliane; Plontke, Stefan K; Mudry, Albert; Steger, Florian

    2015-06-01

    In 1864, Anton von Tröltsch in Würzburg, Hermann Schwartze in Halle/Saale, and Adam Politzer in Vienna founded the Archiv für Ohrenheilkunde (Archive of Otology), the ancestor of the European Archives of Oto-Rhino-Laryngology and Head and Neck. It was the world's first journal solely devoted to otology, and thus to otorhinolaryngology. The aim of this study was to analyse the structure of this journal and its contents during the first 50 years of its publication, until it definitively became an otorhinolaryngological journal in 1915. A total of 2,271 articles were registered during this time. They were classified according to content topic, article type, and the number of figures and graphs that they contained. Almost three-quarters of the articles were related to purely otological topics, as implied by the journal's title. Until the turn of the twentieth century, the majority of the articles were original papers or case reports. The number of original papers declined over the decades in favour of case reports. One-third of each volume usually consisted of a vast variety of items, such as congress announcements, conference proceedings, and book reviews. The journal also maintained a wide variety of scientific and current social and political subjects. Otological reviews and conference proceedings were key landmarks of the journal. All of these various papers provided an overview of the historical organisation and development of otology between 1864 and 1914. At that time, the Archiv für Ohrenheilkunde was a leading national and international journal. PMID:25693880

  17. Association of Behavioral Risk Factors for Chronic Diseases With Physical and Mental Health in European Adults Aged 50 Years or Older, 2004–2005

    PubMed Central

    Papadaki, Angeliki; Smpokos, Emmanouil; Micheli, Katerina; Vozikaki, Maria; Philalithis, Anastas

    2015-01-01

    Introduction Noncommunicable diseases are the leading cause of illness and death worldwide; behavioral risk factors (BRFs) contribute to these diseases. We assessed the presence of multiple BRFs among European adults according to their physical and mental health status. Methods We used data from 26,026 adults aged 50 years or older from 11 countries that participated in the Survey of Health, Ageing and Retirement in Europe (2004–2005). BRFs (overweight or obesity, smoking, physical inactivity, and risky alcohol consumption) were assessed according to physical health (ie, presence of chronic diseases, disease symptoms, or limitations in activities of daily living) and mental health (depression) through multiple regression estimations. Results Overweight or obesity in men and physical inactivity in women were the most prevalent BRFs. Compared with physically active adults, physically inactive adults had a higher mean number of chronic diseases (1.33 vs 1.26) and chronic disease symptoms (1.55 vs 1.47). Risky alcohol consumption (≥4 servings of an alcohol beverage ≥3 times a week) was associated with a higher mean depression score (2.84 vs 2.47). Compared with adults with 0 or 1 BRF, adults with 2 or more BRFs had significantly higher odds of having 1 or more chronic diseases (men: 1.52; women: 1.73) and functional limitations (men: 1.65; women: 1.79) and higher prevalence of high blood pressure (37.8% vs 28.2). Belgian adults with BRFs had the highest mean number of chronic diseases or functional limitations among those who were overweight or obese and the highest mean number of chronic diseases and disease symptoms among those who smoked and were physically inactive. Conclusion We found revealed significant positive associations between BRFs and poor health among middle-aged and older European adults. Primary health care intervention programs should focus on developing ways to reduce BRF prevalence in this population. PMID:26378895

  18. Dysplasia of the contralateral hip in patients with unilateral late-detected congenital dislocation of the hip: 50 years' follow-up of 48 patients.

    PubMed

    Terjesen, T

    2014-09-01

    The aim of this study was to investigate the incidence of dysplasia in the 'normal' contralateral hip in patients with unilateral developmental dislocation of the hip (DDH) and to evaluate the long-term prognosis of such hips. A total of 48 patients (40 girls and eight boys) were treated for late-detected unilateral DDH between 1958 and 1962. After preliminary skin traction, closed reduction was achieved at a mean age of 17.8 months (4 to 65) in all except one patient who needed open reduction. In 25 patients early derotation femoral osteotomy of the contralateral hip had been undertaken within three years of reduction, and later surgery in ten patients. Radiographs taken during childhood and adulthood were reviewed. The mean age of the patients was 50.9 years (43 to 55) at the time of the latest radiological review. In all, eight patients (17%) developed dysplasia of the contralateral hip, defined as a centre-edge (CE) angle < 20° during childhood or at skeletal maturity. Six of these patients underwent surgery to improve cover of the femoral head; the dysplasia improved in two after varus femoral osteotomy and in two after an acetabular shelf operation. During long-term follow-up the dysplasia deteriorated to subluxation in two patients (CE angles 4° and 5°, respectively) who both developed osteoarthritis (OA), and one of these underwent total hip replacement at the age of 49 years. In conclusion, the long-term prognosis for the contralateral hip was relatively good, as OA occurred in only two hips (4%) at a mean follow-up of 50 years. Regular review of the 'normal' side is indicated, and corrective surgery should be undertaken in those who develop subluxation. PMID:25183584

  19. Use of anchoring vignettes to evaluate health reporting behavior amongst adults aged 50 years and above in Africa and Asia – testing assumptions

    PubMed Central

    Hirve, Siddhivinayak; Gómez-Olivé, Xavier; Oti, Samuel; Debpuur, Cornelius; Juvekar, Sanjay; Tollman, Stephen; Blomstedt, Yulia; Wall, Stig; Ng, Nawi

    2013-01-01

    Background Comparing self-rating health responses across individuals and cultures is misleading due to different reporting behaviors. Anchoring vignettes is a technique that allows identifying and adjusting self-rating responses for reporting heterogeneity (RH). Objective This article aims to test two crucial assumptions of vignette equivalence (VE) and response consistency (RC) that are required to be met before vignettes can be used to adjust self-rating responses for RH. Design We used self-ratings, vignettes, and objective measures covering domains of mobility and cognition from the WHO study on global AGEing and adult health, administered to older adults aged 50 years and above from eight low- and middle-income countries in Africa and Asia. For VE, we specified a hierarchical ordered probit (HOPIT) model to test for equality of perceived vignette locations. For RC, we tested for equality of thresholds that are used to rate vignettes with thresholds derived from objective measures and used to rate their own health function. Results There was evidence of RH in self-rating responses for difficulty in mobility and cognition. Assumptions of VE and RC between countries were violated driven by age, sex, and education. However, within a country context, assumption of VE was met in some countries (mainly in Africa, except Tanzania) and violated in others (mainly in Asia, except India). Conclusion We conclude that violation of assumptions of RC and VE precluded the use of anchoring vignettes to adjust self-rated responses for RH across countries in Asia and Africa. PMID:24011254

  20. High alpine ponds shift upwards as average temperatures increase: A case study of the Ortles-Cevedale mountain group (Southern Alps, Italy) over the last 50 years

    NASA Astrophysics Data System (ADS)

    Salerno, Franco; Gambelli, Sara; Viviano, Gaetano; Thakuri, Sudeep; Guyennon, Nicolas; D'Agata, Carlo; Diolaiuti, Guglielmina; Smiraglia, Claudio; Stefani, Fabrizio; Bocchiola, Daniele; Tartari, Gianni

    2014-09-01

    Alpine ecosystems are especially vulnerable to climate change, and lakes and ponds act as early indicators. Here, we describe our findings for the Ortles-Cevedale mountain group (Stelvio National Park, Southern Alps, Italy), where we used remote sensing to analyze more than 100 water ponds over the last 50 years (1954-2007). We found that since the 1980s, some lower elevation ponds (< 2500 m a.s.l.) have disappeared or experienced surface area reduction. We link this impact to the increased evaporation/precipitation ratio associated with climatic warming. At higher elevations (> 2900 m a.s.l.), we observed that since the 1950s, ponds have increased in size and that new ponds have appeared as a consequence of glacial shrinkage and retreat. However, these new ponds are ephemeral. The appearance of new environments is usually followed by their rapid disappearance and by a concomitant appearance of new ones, which is a clear sign of a transition from a glacial system to a paraglacial system. Surface area changes have been shown to be a highly visible and easily measurable signal of the impact of climate change on the alpine environment, as already demonstrated in other remote areas of the world. There is a clear need to extend this analysis to other sites in the Alps to gain a regional understanding of the phenomenon. The findings of this study make it possible to interpret the variations created by climate change in these environments, in terms of alteration of their ecological role and the loss of ecosystem services.

  1. One hundred and twenty-five years of the Annals of Botany. Part 1: the first 50 years (1887–1936)

    PubMed Central

    Jackson, Michael B.

    2015-01-01

    Background The Annals of Botany is a peer-reviewed scientific journal publishing papers on a wide range of topics in plant biology. It first appeared in 1887, making it the oldest continuously published botanical title. The present article gives a historical account of events leading to the founding of the Journal and of its development over the first 50 years. Sources of Information Much of the content is drawn from the Journal’s own records and from extensive Minutes, financial accounts, personal letters and notes relating to the Annals of Botany that were repatriated from University College, University of London in 1999. Documents held at the Royal Botanic Gardens, Kew and at the Oxford University Press Museum were also consulted. Content Emphasis is placed on the individuals who instigated, edited and managed the Annals of Botany up to 1937, especially the nine founding members of the Journal and the background that brought them together and motivated them to start the Annals of Botany. A falling out between two of the founders in 1899 is highlighted since not only did this threaten the Journal’s future but also gives much insight into the personalities of those most closely involved in the Journal during its formative years. The article also examines the way the Journal was funded and how it dealt with its publisher (the University of Oxford’s Clarendon Press), turned itself into a registered company (the Annals of Botany Company) and coped with the travails of the First World War, currency inflation and the Great Depression. Plans to re-start the Journal as a New Series, beginning in 1937, are discussed in the context of the competition the Annals of Botany then faced from younger journals. PMID:25561090

  2. Decision Support in a Changing and Contentious World--Successfully Supporting the Development of a 50-year Comprehensive Coastal Master Plan in Louisiana

    NASA Astrophysics Data System (ADS)

    Groves, D.

    2014-12-01

    After the devastating 2005 hurricane season, Louisiana embarked on an ambitious and daunting effort to develop and implement a comprehensive Coastal Master Plan. The Master Plan sought to achieve two key goals simultaneously: reduce hurricane flood risk and halt the net conversion of its coastal landscape to open ocean. Numerous prior efforts to achieve these goals had been tried without significant success. In 2012, however, the Louisiana Coastal Protection and Restoration Authority (CPRA) produced a 50-year, $50 billion Master Plan. It had broad support from a diverse and often adversarial set of stakeholders, and it was unanimously passed by the Louisiana legislature. In contrast to other efforts, CPRA took an approach to planning called by the U.S. National Research Council as "deliberation with analysis". Specifically, CPRA used data, models, and decision support tools not to define an optimal or best strategy, but instead to support stakeholder dialogue and deliberations over alterative coastal management strategies. RAND researchers, with the support of CPRA and other collaborators, developed the planning tool at the center of this process. The CPRA planning tool synthesized large amounts of information about how the coast might evolve over time with and without different combinations of hundreds of different projects and programs. The tool helped CPRA propose alternative strategies that could achieve the State's goals while also highlighting to stakeholders the key tradeoffs among them. Importantly, this process helped bring diverse communities together to support a single vision and specific set of projects and programs to meet many of Louisiana's coastal water resources challenges. This presentation will describe the planning approach and decision support tools developed to support the Master Plan's participatory stakeholder process. The presentation will also highlight several important key takeaway messages that have broad applicability to other water

  3. Gender-Specific Associations between Perceived Neighbourhood Walkability and Meeting Walking Recommendations When Walking for Transport and Recreation for Czech Inhabitants over 50 Years of Age

    PubMed Central

    Pelclová, Jana; Frömel, Karel; Cuberek, Roman

    2013-01-01

    Few studies have investigated the different effects that the built environment may have on the physical activity behaviours of men and women. Therefore, the aim of this study was to estimate the gender differences in meeting walking recommendations in relation to perceived neighbourhood walkability attributes within the active transportation and leisure-time domains for Czech inhabitants over 50 years of age. The sample included 1,417 men and 1,422 women who were randomly selected. The Abbreviated Neighbourhood Environment Walkability Scale (ANEWS) was used to obtain information about the perceived environment. The self-administered long version of the IPAQ was used to assess physical activity levels. When walking for transport, men living in neighbourhoods with high street connectivity (OR = 1.47, CI = 1.04–2.9) and higher traffic and crime safety (OR = 1.28, CI = 1.02–1.6) and women living in neighbourhoods with high proximity (OR = 1.36, CI = 1.04–1.77) and high neighbourhood aesthetics (OR = 1.36, CI = 1.04–1.76) were more likely to meet recommended levels of walking. No environmental attributes were found to significantly influence the accomplishment of walking recommendations by men or women when walking for leisure. The study results indicate the gender-specific associations between transportation-related walking and the environment factors. The consideration of those factors in the design of gender-specific walking interventions for Czech inhabitants may help the interventions to be more effective in promotion of physical activity. PMID:24380981

  4. Qualitative Assessment of the Impact of Implementing Reiki Training in a Supported Residence for People Older Than 50 Years with HIV/AIDS

    PubMed Central

    Mehl-Madrona, Lewis; Renfrew, Nita M; Mainguy, Barbara

    2011-01-01

    Introduction: Reiki is a Japanese form of energy healing that has become popular in the US. Reiki training involves three stages—levels I, II, and III—to a master practitioner level and requires both giving and receiving Reiki. We set out to implement a program to train clients of a supported residence in Brooklyn, NY. They were all older than age 50 years and had HIV/AIDS and substance-abuse and/or mental-health disorders. Methods: A qualitative, narrative-inquiry study was conducted. The Reiki master kept a journal of her 3 years of providing 90 minutes of Reiki treatment and/or training once weekly at the residence. Forty-five of 50 potential participants attended these sessions with various frequencies. Stories were collected from 35 participants regarding their experience of Reiki training. We posited success as continued involvement in the program. Results: All 35 participants reported receiving benefit from participation in Reiki. Participants first took part in training because of the offered subway tokens; however, 40 continued their involvement despite a lack of compensation. When asked why they continued, participants reported life-changing experiences, including a greater ability to cope with addictions, a greater ability to manage counseling, healing of wounds, improvement of T-cell counts, and improved skills of daily living. Conclusion: Reiki training can be successfully implemented in a supported housing facility with people with HIV/AIDS and comorbid disorders. Some people in our study population reported areas of improvement and life-changing experiences. Our study did not establish the efficacy of Reiki, but our findings support the effect of the entire gestalt of implementing a program related to spirituality and healing and supports the goal of implementing a larger randomized, controlled trial in this setting to establish the efficacy of Reiki. PMID:22058669

  5. Incidences of Herpes Zoster and Postherpetic Neuralgia in Japanese Adults Aged 50 Years and Older From a Community-based Prospective Cohort Study: The SHEZ Study

    PubMed Central

    Takao, Yukiko; Miyazaki, Yoshiyuki; Okeda, Masayuki; Onishi, Fumitake; Yano, Shuichiro; Gomi, Yasuyuki; Ishikawa, Toyokazu; Okuno, Yoshinobu; Mori, Yasuko; Asada, Hideo; Yamanishi, Koichi; Iso, Hiroyasu

    2015-01-01

    Background Many cross-sectional studies have examined the incidences of herpes zoster (HZ) and postherpetic neuralgia (PHN), but prospective studies in Japanese older adults are lacking. Therefore, we conducted a community-based prospective cohort study to determine the incidence in Japanese adults aged ≥50 years. Methods We recruited 12 522 participants from Shozu County, Kagawa Prefecture, between December 2008 and November 2009 and followed participants for 3 years. When a subject presented with symptoms suggestive of HZ, they were examined at collaborating medical institutions and cooperated with onset and recovery surveys (eg, measurement of varicella zoster virus-specific immunity and a pain survey). The hazard ratios (HRs) of HZ and PHN according to sex and age were analyzed by Cox regression analysis with a significance level of 5%. Results The incidence of HZ was 10.9/1000 person-years (men: 8.5/1000 person-years; women: 12.8/1000 person-years) and was significantly higher in women than in men (HR 1.5; 95% confidence interval, 1.2–1.8). The incidence of PHN was 2.1/1000 person-years (men: 1.7/1000 person-years; women: 2.4/1000 person-years), with no significant sex differences. A total of 19% of HZ cases progressed to PHN; no sex-specific difference in the proportion of PHN cases was observed. Conclusions We clarified the accurate incidences of HZ and PHN in a population of Japanese older adults. These incidences increased with age. HZ incidence was higher in women than in men, while PHN incidence did not differ markedly between the sexes. PMID:26399445

  6. Return to Space

    NASA Technical Reports Server (NTRS)

    1989-01-01

    This video documents the preparations for Shuttle Flight STS-26 with Shuttle Discovery, NASA's return to manned space flight after the Challenger disaster. Footage and descriptions document such changes to the new Shuttle as new joints, improved insulation, and added O-rings to the solid rocket boosters; new safety hardware and procedures such as parachute and sidewire evacuations during liftoff, and new pressure suits; modified landing gear, brakes, and nose wheel steering, as well as a modified landing runway. Also profiled are the 5 member crew of all veteran Shuttle astronauts, the TDRS 3 Satellite to be released from the cargo bay in orbit, and 11 commercial and student experiments to be performed during the mission.

  7. Dealing with returned manuscripts.

    PubMed

    Peh, W C G; Ng, K H

    2009-11-01

    It is useful for authors to learn to deal with returned manuscripts with a rejection decision or a request for revision. Common reasons for rejection include contents outside the scope of the journal or inappropriate for the journal, incomplete submission, poor methodology, faulty experimental design, major flaws in the interpretation of results, extremely poor writing, and duplicated or plagiarised work. Authors should use the editor's and reviewers' comments to improve their manuscripts and resubmit elsewhere. Common reasons for revision requests include minor faults in the methodology, minor inaccuracies in data, inconsistencies among different sections of the manuscript, faulty deductions, data that do not support the conclusions, excessive data or text, poor or excessive illustrations, and poor but salvageable writing. A request for revision should be viewed positively, as it means that there is a possibility that the manuscript may still be potentially publishable, provided that all the editor's and reviewers' comments are addressed. PMID:19960157

  8. Return to space

    NASA Astrophysics Data System (ADS)

    1989-08-01

    This video documents the preparations for Shuttle Flight STS-26 with Shuttle Discovery, NASA's return to manned space flight after the Challenger disaster. Footage and descriptions document such changes to the new Shuttle as new joints, improved insulation, and added O-rings to the solid rocket boosters; new safety hardware and procedures such as parachute and sidewire evacuations during liftoff, and new pressure suits; modified landing gear, brakes, and nose wheel steering, as well as a modified landing runway. Also profiled are the 5 member crew of all veteran Shuttle astronauts, the TDRS 3 Satellite to be released from the cargo bay in orbit, and 11 commercial and student experiments to be performed during the mission.

  9. Returns on Investment in California County Departments of Public Health

    PubMed Central

    2016-01-01

    Objectives. To estimate the average return on investment for the overall activities of county departments of public health in California. Methods. I gathered the elements necessary to estimate the average return on investment for county departments of public health in California during the period 2001 to 2008–2009. These came from peer-reviewed journal articles published as part of a larger project to develop a method for determining return on investment for public health by using a health economics framework. I combined these elements by using the standard formula for computing return on investment, and performed a sensitivity analysis. Then I compared the return on investment for county departments of public health with the returns on investment generated for various aspects of medical care. Results. The estimated return on investment from $1 invested in county departments of public health in California ranges from $67.07 to $88.21. Conclusions. The very large estimated return on investment for California county departments of public health relative to the return on investment for selected aspects of medical care suggests that public health is a wise investment. PMID:27310339

  10. 5 CFR 353.205 - Return to duty and application for reemployment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Return to duty and application for... Return to duty and application for reemployment. Periods allowed for return to duty are based on the... to determine fitness for the uniformed services, is required to report back to work not later...

  11. 26 CFR 31.6071(a)-1 - Time for filing returns and other documents.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Information returns—(i) General rule. Each information return in respect of wages as defined in the Federal...)-5(a) is filed as a final return for a period ending prior to December 31, the information statement... return required to be made under §§ 31.6011(a)-1 and 31.6011(a)-1T, in respect of the taxes imposed...

  12. Economic Returns to Education: What We Know, What We Don't Know, and Where We Are Going-Some Brief Pointers

    ERIC Educational Resources Information Center

    Dickson, Matt; Harmon, Colm

    2011-01-01

    The estimation of the economic return to education has perhaps been one of the predominant areas of analysis in applied economics for over 50 years. In this short note we consider some of the recent directions taken by the literature, and also some of the blockages faced by both science and policymakers in pushing forward some key issues. This…

  13. 50 Years And 400 Radiocarbon Measurements Since 1959: What Has The “Bomb Spike” Taught Us About Soil C Dynamics In New Zealand Soils?

    NASA Astrophysics Data System (ADS)

    Baisden, W. T.; Parfitt, R. L.; Ross, C.

    2009-12-01

    In 1959, Athol Rafter began a substantial programme of monitoring the flow of 14C produced by atmospheric thermonuclear tests through New Zealand’s atmosphere, biosphere and soil. The programme produced important publications, but also leaves a legacy of unpublished data critical for understanding soil C dynamics. A database of ~400 soil radiocarbon measurements spanning 50 years has now been compiled. Among the most compelling data is a comparison of soil carbon dynamics in deforested dairy pastures under similar climate in the Tokomaru silt loam (non-Andisol) versus the Egmont black loam (Andisol), originally sampled in 1962-3, 1965 and 1969. After adding soil profiles sampled to similar depths in 2008, we can use a relatively simple 2-box model to calculate that the residence time of soil C (upper ~8 cm) in the Tokomaru soil is ~9 years compared to ~15 years for the Egmont soil. This difference represents nearly a doubling of soil C residence time, and roughly explains the doubling of the soil C stock. With three measurements in the 1960s, the data is of sufficient resolution to estimate the parameters for an “inert” or “passive pool” comprising approximately 15% of soil C, and having a residence time of 600 years in the Tokomaru soil versus 3000 years in the Egmont surface soil. The Tokomaru/Egmont comparison is necessarily illustrative since the 1960s samplings were not replicated extensively, but provides globally unique data illustrating the nature of C movement through soil. Moreover, the Tokomaru/Egmont comparison supports evidence that C dynamics does differ in Andisols versus other soils. Additional lines of evidence include emerging theories of soil organic matter stabilisation processes, rates of soil organic matter change following land-use change, and chemistry data. The contrasting soil C dynamics in these different soils appear to have implications for land-use change and management schemes that could be eligible for “C credits”. More

  14. Multivariate models of adult Pacific salmon returns.

    PubMed

    Burke, Brian J; Peterson, William T; Beckman, Brian R; Morgan, Cheryl; Daly, Elizabeth A; Litz, Marisa

    2013-01-01

    Most modeling and statistical approaches encourage simplicity, yet ecological processes are often complex, as they are influenced by numerous dynamic environmental and biological factors. Pacific salmon abundance has been highly variable over the last few decades and most forecasting models have proven inadequate, primarily because of a lack of understanding of the processes affecting variability in survival. Better methods and data for predicting the abundance of returning adults are therefore required to effectively manage the species. We combined 31 distinct indicators of the marine environment collected over an 11-year period into a multivariate analysis to summarize and predict adult spring Chinook salmon returns to the Columbia River in 2012. In addition to forecasts, this tool quantifies the strength of the relationship between various ecological indicators and salmon returns, allowing interpretation of ecosystem processes. The relative importance of indicators varied, but a few trends emerged. Adult returns of spring Chinook salmon were best described using indicators of bottom-up ecological processes such as composition and abundance of zooplankton and fish prey as well as measures of individual fish, such as growth and condition. Local indicators of temperature or coastal upwelling did not contribute as much as large-scale indicators of temperature variability, matching the spatial scale over which salmon spend the majority of their ocean residence. Results suggest that effective management of Pacific salmon requires multiple types of data and that no single indicator can represent the complex early-ocean ecology of salmon. PMID:23326586

  15. Return Migration to Mexico: Does Health Matter?

    PubMed

    Arenas, Erika; Goldman, Noreen; Pebley, Anne R; Teruel, Graciela

    2015-12-01

    We use data from three rounds of the Mexican Family Life Survey to examine whether migrants in the United States returning to Mexico in the period 2005-2012 have worse health than those remaining in the United States. Despite extensive interest by demographers in health-related selection, this has been a neglected area of study in the literature on U.S.-Mexico migration, and the few results to date have been contradictory and inconclusive. Using five self-reported health variables collected while migrants resided in the United States and subsequent migration history, we find direct evidence of higher probabilities of return migration for Mexican migrants in poor health as well as lower probabilities of return for migrants with improving health. These findings are robust to the inclusion of potential confounders reflecting the migrants' demographic characteristics, economic situation, family ties, and origin and destination characteristics. We anticipate that in the coming decade, health may become an even more salient issue in migrants' decisions about returning to Mexico, given the recent expansion in access to health insurance in Mexico. PMID:26385111

  16. Multivariate Models of Adult Pacific Salmon Returns

    PubMed Central

    Burke, Brian J.; Peterson, William T.; Beckman, Brian R.; Morgan, Cheryl; Daly, Elizabeth A.; Litz, Marisa

    2013-01-01

    Most modeling and statistical approaches encourage simplicity, yet ecological processes are often complex, as they are influenced by numerous dynamic environmental and biological factors. Pacific salmon abundance has been highly variable over the last few decades and most forecasting models have proven inadequate, primarily because of a lack of understanding of the processes affecting variability in survival. Better methods and data for predicting the abundance of returning adults are therefore required to effectively manage the species. We combined 31 distinct indicators of the marine environment collected over an 11-year period into a multivariate analysis to summarize and predict adult spring Chinook salmon returns to the Columbia River in 2012. In addition to forecasts, this tool quantifies the strength of the relationship between various ecological indicators and salmon returns, allowing interpretation of ecosystem processes. The relative importance of indicators varied, but a few trends emerged. Adult returns of spring Chinook salmon were best described using indicators of bottom-up ecological processes such as composition and abundance of zooplankton and fish prey as well as measures of individual fish, such as growth and condition. Local indicators of temperature or coastal upwelling did not contribute as much as large-scale indicators of temperature variability, matching the spatial scale over which salmon spend the majority of their ocean residence. Results suggest that effective management of Pacific salmon requires multiple types of data and that no single indicator can represent the complex early-ocean ecology of salmon. PMID:23326586

  17. 11. VIEW OF A SITE RETURN WEAPONS COMPONENT. SITE RETURNS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. VIEW OF A SITE RETURN WEAPONS COMPONENT. SITE RETURNS WERE NUCLEAR WEAPONS SHIPPED TO THE ROCKY FLATS PLANT FROM THE NUCLEAR WEAPON STOCKPILE FOR RETIREMENT, TESTING, OR UPGRADING. FISSILE MATERIALS (PLUTONIUM, URANIUM, ETC.) AND RARE MATERIALS (BERYLLIUM) WERE RECOVERED FOR REUSE, AND THE REMAINDER WAS DISPOSED. (8/7/62) - Rocky Flats Plant, Plutonium Fabrication, Central section of Plant, Golden, Jefferson County, CO

  18. Changes in Returns to Education in India, 1983-94: By Gender, Age-Cohort and Location. Center Discussion Paper.

    ERIC Educational Resources Information Center

    Duraisamy, P.

    There is hardly any estimate of returns to schooling in India based on national level representative data for the recent period. This paper provides estimates of the economic returns to education in India by gender, age cohort, and location (by rural-urban) for the most recent period 1993-94, and also evaluates the changes in returns over a period…

  19. Christmas Island birds returning

    NASA Astrophysics Data System (ADS)

    Six months after their mass exodus, birds are beginning to return to Christmas Island. Roughly 17 million birds, almost the entire adult bird population, either perished or fled their mid-Pacific atoll home last autumn, leaving behind thousands of nestlings to starve (Eos, April 5, 1983, p. 131). It is believed that the strong El Niño altered the ecology of the surrounding waters and forced the birds to flee. Christmas Island is the world's largest coral atoll.“Ocean and atmosphere scientists are unsure of future directions for the El Niño conditions and cannot now predict what will happen to the birds in the coming months,” said Ralph W. Schreiber, curator of ornithology at the Natural History Museum of Los Angeles County in California. Heisthe ornithologist who discovered the disappearance. “The recovery of the bird populations depends on the food supply in the waters surrounding the island.” The island's birds feed exclusively on small fish and squid.

  20. A Retrospective Study Evaluating the Impact of Preoperative Breast MRI on Surgical Decision-Making in Young Patients (≤50 Years) with Invasive Breast Cancer

    PubMed Central

    Mukherjee, Som D.; Hodgson, Nicole; Lovrics, Peter J.; Dhamanaskar, Kavita; Minuk, Terry; Chambers, Shelley; Sussman, Jonathan

    2016-01-01

    INTRODUCTION Breast magnetic resonance imaging (MRI) is considered a more sensitive diagnostic test for detecting invasive breast cancer than mammography or breast ultrasound. Breast MRI may be particularly useful in younger premenopausal women with higher density breast tissue for differentiating between dense fibroglandular breast tissue and breast malignancies. The main objective of this study was to determine the impact of preoperative breast MRI on surgical decision-making in young women with breast cancer. METHODS A retrospective review of patients with newly diagnosed invasive breast cancer and age of ≤50 years was performed. All patients underwent physical examination, preoperative mammogram, breast ultrasound, and bilateral breast MRI. Two breast cancer surgeons reviewed the preoperative mammogram report, breast ultrasound report, and physical examination summary and were asked if they would recommend a lumpectomy, a quandrantectomy, or a mastectomy. A few weeks later, the two surgeons were shown the same information with the breast MRI report and were asked what type of surgery they would now recommend. In each case, MRI was classified by two adjudicators as having affected the surgical outcome in a positive, negative, or neutral fashion. A positive impact was defined as the situation where breast MRI detected additional disease that was not found on physical examination, mammogram, or breast ultrasound and led to an appropriate change in surgical management. A negative impact was defined as the situation where breast MRI led the surgeon to recommend more extensive surgery, with less extensive disease actually found at pathology. No impact was defined as the situation where MRI findings did not alter surgical recommendations or outcomes. RESULTS Of 37 patients whose charts were reviewed, five patients were deemed to be ineligible due to having received neoadjuvant chemotherapy, having previous breast implants, or having had their tumor fully excised

  1. Close deciphering of the sediment record of stable and radioactive contamination in the upper Seine estuary, over the last 50 years: a phosphogypsum legacy

    NASA Astrophysics Data System (ADS)

    Vrel, A.; Boust, D.; Lesueur, P.; Deloffre, J.; Dillies, R.; Rozet, M.; Solier, L.; Dubrulle-Brunaud, C.; Cossonnet, C.; Thomas, S.

    2012-04-01

    The Seine estuary is the outlet of a huge catchment area (the Basin of Paris), into which fine sediments and anthropogenic elements and substances end in. In the upper Seine estuary, stable and radioactive contaminants come both from upstream and from local in the industrialized agglomeration of Rouen. It is particularly challenging to decipher the relative contribution of these two sources due to the lack of historical data for most of the contaminants of concern. The key issue was the collection of two sediment cores: (1) in a flood plain of the lower Seine River and (2) in an old careening basin of the Rouen harbour which was not dredged since many decades. These cores were carefully dated using artificial radionuclide (atmospheric fallout from Chernobyl and nuclear weapon tests - 137Cs - or discharges in the river - 238Pu) and signal processing techniques and an accurate model age was obtained, yielding a 50 years long sediment record. Major elements, 44 trace elements and 14 naturally-occurring radionuclides (235U, 238U and 232Th series) were measured by ICP-AES, ICP-MS and gamma-spectrometry. As some elements display no almost constant (Co, Cs, Ga, Ge, Hf, Nb, Rb, Sr, Ta, V) or continuous decreasing concentrations (Ag, As, Pb, Sb, Sn, W, Zn) since the early 60's, some others show much higher concentrations (Ba, Be, Bi, Cd, Cr, Cu, Mo, Ni, Y and lanthanides, U and, to a lesser extent, Th series) from mid-60's to mid-80's, and only in the core collected in the Rouen harbour. Even if some minor contributions cannot be ruled out, it is likely that these huge excess concentrations (up to 50 times) are due to the phosphate fertilizer industry. In fact, between 1960 and 1984, the upper Seine estuary underwent big direct discharges of phosphogypsum (an acidic by-product of the process) from two plants located in the vicinity of the Rouen harbour, which peaked up to 1million tons per year in 1974. Cd and Bi are, from far, the most enriched stable elements (up to 300

  2. Return to sport after arthroscopic meniscectomy on stable knees

    PubMed Central

    2013-01-01

    Background Athletes suffering from any injuries want to know when they will be able to return sports activity. The period of return-to-sport after the arthroscopic meniscectomy is still unknown. The aim of this study is to investigate the period of the return-to-sport from surgery and the clinical symptoms after the meniscectomy on stable knees. Methods Fifty-six athletes who underwent the arthroscopic meniscectomy were evaluated. The patients with an average age of 26.7 years (range, 13–67) comprised 45 men and 11 women, 16 medial meniscus and 40 lateral meniscus injuries. The average of the follow-up period was 9.2 months. The parameter examined were age, the injured side of meniscus (medial or lateral), articular cartilage status, amount of resection, and sports activity level. Results The mean period was 54 days in young group, and was 89 days in old group (p = 0.0013). The period was 79 days in medial meniscus (MM) injured group, and was 61 days in lateral meniscus (LM) group (p = 0.017). There was a significant difference among the groups in activity levels and in amount of resection. Pain and/or effusion in the knee after the return-to-sport were found 22% of the MM group and 53% in the LM group. Conclusions The period of the return-to-sport was shorter in young age, high activity and large amount of resection group. Although athletes in LM group can return to sports earlier than those in MM group, more than half of athletes have pain or effusion at the time of return-to sport. PMID:24257295

  3. Bulgarian Turkish emigration and return.

    PubMed

    Vasileva, D

    1992-01-01

    The main factors which determined the 1989 migration of Turks in Bulgaria back to Turkey are discussed. Background history is provided. After World War I, Turks in bulgaria comprised 10% of the total population. Bulgarian policy had been, up to the 1980s to send Rumelian Turks back, but the policy after 1980 was one of a national revival process to integrate Turks into the developed socialist society. Muslim traditions, customs, and Turkish language were interfered with. International disfavor resulted. In May 1989, the Communist Party declared, in an effort to show democratic ideals, open borders. Thus began the new emigration wave. 369,839 people fled to the Turkish border. 43% of the 9.47 ethnic Turks in bulgaria went to Turkey within 4 months. The numbers decreased in November, and soon after the communist regime ended. New laws were adopted allowing Turks to assume their original Turkish names. The huge migration was clearly political, and as such, the emigrant Turks should be determined as refugees and asylum seekers. The provocation of ethnic Turks was used by the communist regime to solve potential social conflicts. Not only did Turks flee to escape from violence or for religious, cultural, and moral reasons but also due to free market initiatives begun in Turkey in the early 1980s which improved Turkish quality of life. Food and consumer goods were cheaper and economic advantages were perceived. Emigrants were primarily peasants with lower levels of education, professional qualifications, and labor skills. 154,937 (42%) returned to bulgaria and 58% stayed in Turkey to comprise 25% of the former Turkish population. During this period, tensions between countries was high.l Bulgarians actively encouraged emigration and Turkey welcomed it. The emigrants to Turkey were seen as foreigners (muhacir or gocmen) but were received with good will and were readily accepted into menial positions. Emigrants were confronted with political, linguistic, and cultural

  4. Non-Returning Student Survey.

    ERIC Educational Resources Information Center

    Charles County Community Coll., La Plata, MD. Dept. of Institutional Research and Assessment.

    In spring 1992, Charles County Community College (CCCC) conducted a telephone survey of non-returning fall 1991 students to determine their reasons for not returning to CCCC. In order to obtain comparison data, a questionnaire designed and administered by Prince George's Community College (PGCC) (Largo, Maryland) in 1988 was used with one minor…

  5. Capital Structure and Stock Returns

    ERIC Educational Resources Information Center

    Welch, Ivo

    2004-01-01

    U.S. corporations do not issue and repurchase debt and equity to counteract the mechanistic effects of stock returns on their debt-equity ratios. Thus over one- to five-year horizons, stock returns can explain about 40 percent of debt ratio dynamics. Although corporate net issuing activity is lively and although it can explain 60 percent of debt…

  6. Returns to Education and Economic Transition: An International Comparison

    ERIC Educational Resources Information Center

    Hung, Fan-sing

    2008-01-01

    This paper compares the returns to education in transitional economies in Central and Eastern Europe (CEE), such as Bulgaria, the Czech Republic, Romania, Russia, Slovak Republic and the Ukraine in the 1990s, and in China in the 1980s and 1990s. In the pre-transition period, the returns to education in the six CEE countries were low at about 2-4%,…

  7. Returning Evidence at the Appeals Council Level. Final rule.

    PubMed

    2016-02-01

    This final rule adopts the notice of proposed rulemaking (NPRM) that we published in the Federal Register on October 21, 2015. This final rule revises our rules regarding returning evidence at the Appeals Council (AC) level. Under this final rule, the AC will no longer return additional evidence it receives when the AC determines the additional evidence does not relate to the period on or before the date of the administrative law judge (ALJ) decision. PMID:26859901

  8. Variation of the Earth tide-seismicity compliance parameter the last 50 years for the west site of the Aegean Volcanic Arc, Greece

    NASA Astrophysics Data System (ADS)

    Contadakis, M. E.; Arabelos, D. N.; Vergos, G.; Spatalas, S.

    2015-07-01

    Based on the results of our studies for the tidal triggering effect on the seismicity of the Hellenic area, we consider the confidence level of earthquake occurrence - tidal period accordance as an index of tectonic stress criticality for earthquake occurrence and we check if the recent increase in the seismic activity at the west site of the Aegean Volcanic Arc indicate faulting maturity for a stronger earthquake. In this paper we present the results of this test which are positive.

  9. AKATSUKI returns to Venus

    NASA Astrophysics Data System (ADS)

    Nakamura, Masato; Imamura, Takeshi; Ishii, Nobuaki; Abe, Takumi; Kawakatsu, Yasuhiro; Hirose, Chikako; Satoh, Takehiko; Suzuki, Makoto; Ueno, Munetaka; Yamazaki, Atsushi; Iwagami, Naomoto; Watanabe, Shigeto; Taguchi, Makoto; Fukuhara, Tetsuya; Takahashi, Yukihiro; Yamada, Manabu; Imai, Masataka; Ohtsuki, Shoko; Uemizu, Kazunori; Hashimoto, George L.; Takagi, Masahiro; Matsuda, Yoshihisa; Ogohara, Kazunori; Sato, Naoki; Kasaba, Yasumasa; Kouyama, Toru; Hirata, Naru; Nakamura, Ryosuke; Yamamoto, Yukio; Horinouchi, Takeshi; Yamamoto, Masaru; Hayashi, Yoshi-Yuki; Kashimura, Hiroki; Sugiyama, Ko-ichiro; Sakanoi, Takeshi; Ando, Hiroki; Murakami, Shin-ya; Sato, Takao M.; Takagi, Seiko; Nakajima, Kensuke; Peralta, Javier; Lee, Yeon Joo; Nakatsuka, Junichi; Ichikawa, Tsutomu; Inoue, Kozaburo; Toda, Tomoaki; Toyota, Hiroyuki; Tachikawa, Sumitaka; Narita, Shinichiro; Hayashiyama, Tomoko; Hasegawa, Akiko; Kamata, Yukio

    2016-05-01

    AKATSUKI is the Japanese Venus Climate Orbiter that was designed to investigate the climate system of Venus. The orbiter was launched on May 21, 2010, and it reached Venus on December 7, 2010. Thrust was applied by the orbital maneuver engine in an attempt to put AKATSUKI into a westward equatorial orbit around Venus with a 30-h orbital period. However, this operation failed because of a malfunction in the propulsion system. After this failure, the spacecraft orbited the Sun for 5 years. On December 7, 2015, AKATSUKI once again approached Venus and the Venus orbit insertion was successful, whereby a westward equatorial orbit with apoapsis of ~440,000 km and orbital period of 14 days was initiated. Now that AKATSUKI's long journey to Venus has ended, it will provide scientific data on the Venusian climate system for two or more years. For the purpose of both decreasing the apoapsis altitude and avoiding a long eclipse during the orbit, a trim maneuver was performed at the first periapsis. The apoapsis altitude is now ~360,000 km with a periapsis altitude of 1000-8000 km, and the period is 10 days and 12 h. In this paper, we describe the details of the Venus orbit insertion-revenge 1 (VOI-R1) and the new orbit, the expected scientific information to be obtained at this orbit, and the Venus images captured by the onboard 1-µm infrared camera, ultraviolet imager, and long-wave infrared camera 2 h after the successful initiation of the VOI-R1.

  10. APOLLO 11: The heroes Return

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The crew of APOLLO 11 return as heroes after their succesfull landing on the lunar surface. From the film documentary 'APOLLO 11:'The Eagle Has Landed'', part of a documentary series on the APOLLO missions made in the early '70's and narrated by Burgess Meredith. APOLLO 11: First manned lunar landing and return to Earth with Neil A. Armstrong, Michael Collins, and Edwin E. Aldrin. Landed in the Sea of Tranquilityon July 20, 1969; deployed TV camera and EASEP experiments, performed lunar surface EVA, returned lunar soil samples. Mission Duration 195 hrs 18 min 35sec

  11. Using high resolution imagery to detect woody vegetation and land-cover change over 50 years in the Sahel of Mali

    NASA Astrophysics Data System (ADS)

    Spiekermann, Raphael; Brandt, Martin; Samimi, Cyrus

    2013-04-01

    The Sahel region has been acclaimed as one of the "hot spots" of global environmental change in the last decades. The degradation of the environmental conditions was accelerated by prolonged droughts in the region during the 1970s and 1980s and an overall decrease in annual precipitation. The resulting loss of woody vegetation cover was often considered as irreversible desertification. Recent findings, based on small-scaled analyses of satellite images, show an increase of vegetation greenness over most parts of the Sahel since the mid-1980s. However, due to a lack of detailed regional studies, it remains largely unclear if this is a return to pre-drought conditions or a transformation of land cover to a new equilibrium state. This study intends to use remote sensing techniques, supplemented by ground truth data to compare the pre-drought woody vegetation and land cover with the current situation. High resolution panchromatic Corona imagery of 1967 and multispectral RapidEye imagery of 2011 form the basis of this regional scaled study, which includes parts of the Dogon Plateau and the Seno Plains in the Sahel of Mali. The feature extraction and classification operations included in ERDAS Imagine Objective are used in an object-oriented approach in combination with spectral properties to analyse the datasets and map millions of individual trees and large shrubs. Results indicate number of trees per hectare as well as woody vegetation coverage in percent per hectare for both 1967 and 2011. Additionally, the land-cover change during the past half century is assessed followed by an analysis of current and past woody vegetation densities in relation to land-cover classes. Results show a significant increase of cultivated land, in particular in the Seno Plains, a reduction of dense natural woody vegetation as well as an increase of trees on farmer's fields on the Dogon Plateau. Our results show that neither the desertification paradigm nor the greening paradigm can be

  12. 26 CFR 301.7701(b)-4 - Residency time periods.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... statement (described in paragraph (c)(3)(v)(C) of this section) to the individual's income tax return (Form... tax return for the election year, the alien individual may request an extension of time for filing the return until a reasonable period after he or she has satisfied such test, provided that the...

  13. Irregular Periods

    MedlinePlus

    ... number of days after the last one. The Menstrual Cycle Most girls get their first period between the ... to skip periods or to have an irregular menstrual cycle. Illness, rapid weight change, or stress can also ...

  14. Earnings Quality Measures and Excess Returns

    PubMed Central

    Perotti, Pietro; Wagenhofer, Alfred

    2014-01-01

    This paper examines how commonly used earnings quality measures fulfill a key objective of financial reporting, i.e., improving decision usefulness for investors. We propose a stock-price-based measure for assessing the quality of earnings quality measures. We predict that firms with higher earnings quality will be less mispriced than other firms. Mispricing is measured by the difference of the mean absolute excess returns of portfolios formed on high and low values of a measure. We examine persistence, predictability, two measures of smoothness, abnormal accruals, accruals quality, earnings response coefficient and value relevance. For a large sample of US non-financial firms over the period 1988–2007, we show that all measures except for smoothness are negatively associated with absolute excess returns, suggesting that smoothness is generally a favorable attribute of earnings. Accruals measures generate the largest spread in absolute excess returns, followed by smoothness and market-based measures. These results lend support to the widespread use of accruals measures as overall measures of earnings quality in the literature. PMID:26300582

  15. Different forms, reasons and motivations for return migration of persons who voluntarily decide to return to their countries of origin.

    PubMed

    Callea, S

    1986-03-01

    Although the 1973 oil crisis did not have the drastic effects on immigration which were originally feared, it did end a period of quasi-liberal immigration policy, establish intense and effective international cooperation on immigration, and arouse great interest in immigration studies and research. This paper analyzes the situations arising as a result of the petroleum shortage and focuses on the conditions relating to the return of emigrants to Southern European countries. This new research draws attention to the following fundamental aspects of the immigration problem: 1) the emigrant's return to his homeland cannot be considered a factor in development; it is a positive element in development only if the right socioeconomic conditions exist in the country of origin. 2) Concern for children's education is one of the most common reasons for return. 3) A large percentage of emigrants are satisfied with their work abroad. 4) An emigrant's return potential is wasted due to the slight use that is made of the resources he offers. 5) Returning workers most often want to set up an independent enterprise. 6) Savings are generally used to buy a house or farm. 7) Vocational level does not increase significantly between emigration and returning, though this increase becomes greater the longer the emigrant stays abroad. 8) The number of returning emigrants is too slight to bring about any change in the country of origin. 9) Incentives and subsidies to encourage return have not had a considerable impact on the decision to return. Callea recommends that officials of the country of origin posted abroad be assigned to counsel returning emigrants on finding employment, attending vocational development courses, obtaining housing, accruing interests and savings, and on the problems and perspectives of sociocultural reintegration. PMID:12314946

  16. Leaving from and returning to nursing practice: contributing factors.

    PubMed

    Jamieson, Isabel; Taua, Chris

    2009-07-01

    Many nurses leave nursing and never return. Others return after a period of time. Given the global shortage of nurses a better understanding of these movements is needed. The present study focused on nurses who had been out of nursing for more than five years, and explored factors that influenced their leaving and return to practice. All the nurses who had undertaken a Competency Assessment Programme at a given New Zealand tertiary institution during 2005 were invited to participate. Of the 70 questionnaires mailed out 32 (44.5%) were completed and returned. Quantitative data were analysed using Microsoft Excel, and the qualitative data were coded and analysed by means of content analysis. For each, leaving and returning, three key issues emerged. Nurses left for personal reasons, to seek a career change, or because of poor working conditions. They returned when they had the personal freedom to do so, for fiscal reasons, or because they were motivated by some sense of unfinished business. These findings indicate that it is important for educators involved with Competency Assessment Programmes to collaborate with employers in ensuring that there are opportunities for re-entry to positive work environments, with a degree of flexibility that suits the demographic characteristics of those nurses returning to practice. PMID:19928648

  17. 28 CFR 540.24 - Returned mail.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... contraband all undelivered mail returned to an institution by the Post Office before returning it to the.... Any returned mail qualifying as “special mail” is opened and inspected for contraband in the...

  18. 28 CFR 540.24 - Returned mail.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... contraband all undelivered mail returned to an institution by the Post Office before returning it to the.... Any returned mail qualifying as “special mail” is opened and inspected for contraband in the...

  19. New times of minimum and a period study for GO Cygni

    NASA Technical Reports Server (NTRS)

    Hall, Douglas S.; Louth, Howard

    1990-01-01

    Times of minimum derived from photometry obtained in 1963, 1967, 1978, and 1979 are presented. With these and previously published times, the period is studied. A constant period increase (quadratic ephemeris) represents most of the times but there was a period decrease in 1934 and possibly in 1984. A 50-year magnetic cycle is discussed.

  20. Non-Contrast-Enhanced Whole-Body Magnetic Resonance Imaging in the General Population: The Incidence of Abnormal Findings in Patients 50 Years Old and Younger Compared to Older Subjects

    PubMed Central

    Cieszanowski, Andrzej; Maj, Edyta; Kulisiewicz, Piotr; Grudzinski, Ireneusz P.; Jakoniuk-Glodala, Karolina; Chlipala-Nitek, Irena; Kaczynski, Bartosz; Rowinski, Olgierd

    2014-01-01

    Purpose To assess and compare the incidence of abnormal findings detected during non-contrast-enhanced whole-body magnetic resonance imaging (WB-MRI) in the general population in two age groups: (1) 50 years old and younger; and (2) over 50 years old. Materials and Methods The analysis included 666 non-contrast-enhanced WB-MRIs performed on a 1.5-T scanner between December 2009 and June 2013 in a private hospital in 451 patients 50 years old and younger and 215 patients over 50 years old. The following images were obtained: T2-STIR (whole body-coronal plane), T2-STIR (whole spine-sagittal), T2-TSE with fat-saturation (neck and trunk-axial), T2-FLAIR (head-axial), 3D T1-GRE (thorax-coronal, axial), T2-TSE (abdomen-axial), chemical shift (abdomen-axial). Detected abnormalities were classified as: insignificant (type I), potentially significant, requiring medical attention (type II), significant, requiring treatment (type III). Results There were 3375 incidental findings depicted in 659 (98.9%) subjects: 2997 type I lesions (88.8%), 363 type II lesions (10.8%) and 15 type III lesions (0.4%), including malignant or possibly malignant lesions in seven subjects. The most differences in the prevalence of abnormalities on WB-MRI between patients 50 years old and younger and over 50 years old concerned: brain infarction (22.2%, 45.0% respectively), thyroid cysts/nodules (8.7%, 18.8%), pulmonary nodules (5.0%, 16.2%), significant degenerative disease of the spine (23.3%, 44.5%), extra-spinal degenerative disease (22.4%, 61.1%), hepatic steatosis (15.8%, 24.9%), liver cysts/hemangiomas (24%, 34.5%), renal cysts (16.9%, 40.6%), prostate enlargement (5.1% of males, 34.2% of males), uterine fibroids (16.3% of females, 37.9% of females). Conclusions Incidental findings were detected in almost all of the subjects. WB-MRI demonstrated that the prevalence of the vast majority of abnormalities increases with age. PMID:25259581

  1. The water fluxes of the Yellow River to the sea in the past 50 years, in response to climate change and human activities.

    PubMed

    Jiongxin, Xu

    2005-05-01

    Since the 1970s, the water fluxes to the sea of the Yellow River have declined significantly. Based on data of precipitation, air temperature, the measured and "natural" river flow, the water diversion and consumption, and the areas of erosion and sediment control measures over the drainage basin, water fluxes to the sea of the Yellow River are studied in relation with the influences of changing climate and human activities. The Yellow River basin can be divided into different water source areas; multiple regression indicates that the variation in precipitation over different water source areas has different effect on water fluxes to the sea. In the period between 1970 and 1997, averaged air temperature over the whole Yellow River increased by about 1.0 degree C, from 16.5 degrees C to 17.5 degrees C, a factor that is negatively correlated with the water yield of the Yellow River. Water diversion and consumption has sharply increased and resulted in a significant decline in the water fluxes to the sea. Since the 1960s, erosion and sediment control measures have been practiced over the drainage basin. This factor, to a lesser degree, is also responsible for the decrease in water fluxes to the sea. A multiple regression equation has been established to estimate the change in water fluxes to the sea caused by the changes in precipitation, air temperature, water diversion and consumption, erosion, and sediment control measures, indicating that the contribution of water diversion and consumption to the variation in annual water flux to the sea is 41.3%, that of precipitation is 40.8%, that of temperature is 11.4%, and that of erosion and sediment control measures is 6.5%. PMID:15924206

  2. [Evolution of physical fitness and functional capacity in active elderly women over 50 years of age according to chronological age in Santos city].

    PubMed

    Penha, José Carlos Lopes; Piçarro, Ivan da Cruz; de Barros Neto, Turibio Leite

    2012-01-01

    The scope of this study was to compare the evolution of physical fitness, functional capacity and bone mineral density in active elderly women over a one-year period. The sample consisted of 78 women from 50 to 79 years of age (c:62.4 ± 7.1) participating in an aerobic program, twice a week, 50 minutes per session during 3.4 years and divided into three age groups: A: 50-59 (n:38); B: 60-69 (n:28); C: 70-79 (n:12). Results were compared using Two Way ANOVA, "post-hoc" Bonferroni and delta (D%) variations (*p<.o1). The velocity of rising from a chair and gait speed revealed a significant difference in the three groups ranging from -14.3% to -45.5%; there was a significant improvement in A and B groups in walking speed (-12.1% to -13.9%), and also in maximum gait speed (-15.4% to -18.5%), elbow flexion in all the groups (18.9% to 24.1%), vertical jump (22.5% to 43.9%) in groups B and C, and rising from a chair in 30 seconds (25.2% to 30.8%) in groups A and B, the flexibility test showed an increase in group A (16.2% to 33.3%) and stationary walking in the three groups of (16,4% 30.0%) and bone mineral density (BMD) presented a significant increase (3.1% to 10.2%). The results indicate the salutary effect of regular physical activity. PMID:22218558

  3. Predictors of returning to work.

    PubMed

    Ash, P; Goldstein, S I

    1995-01-01

    An investigation of predictors of returning to work in a sample of physically injured persons who are receiving workers' compensation benefits and vocational rehabilitation is presented. One hundred fourteen injured subjects (86 with back injury; 28, other injury) undergoing vocational rehabilitation and receiving workers' compensation benefits were assessed on demographic, emotional, cognitive, financial incentive, and miscellaneous variables. Predictors for returning to work were identified using stepwise logistic regression. Patients with moderate or severe depression, defined as a score greater than 16 on the Beck Depression Inventory (BDI), were significantly less likely to return to work following vocational rehabilitation efforts than patients with less severe depression (for back-injured patients, odds ratio (OR) = 31, 95% CI [8.8, 108]). BDI scores correctly classified 84 percent of the back-injury and 86% of the other-injury groups with respect to their return to work. The level of workers' compensation benefit was the only variable that added (marginally) to the predictive power of the BDI. In a physically injured population receiving workers' compensation benefits, who are judged to be not clearly permanently disabled, level of depressive symptoms is a strong predictor of returning to work. Caution is warranted in using the BDI as the sole determinant in a forensic situation for making a real-world prediction, as BDI responses are easy to fake. Treatment of concurrent depression is an important component of helping physically injured workers resume gainful employment. PMID:8605404

  4. Probability distribution of extreme share returns in Malaysia

    NASA Astrophysics Data System (ADS)

    Zin, Wan Zawiah Wan; Safari, Muhammad Aslam Mohd; Jaaman, Saiful Hafizah; Yie, Wendy Ling Shin

    2014-09-01

    The objective of this study is to investigate the suitable probability distribution to model the extreme share returns in Malaysia. To achieve this, weekly and monthly maximum daily share returns are derived from share prices data obtained from Bursa Malaysia over the period of 2000 to 2012. The study starts with summary statistics of the data which will provide a clue on the likely candidates for the best fitting distribution. Next, the suitability of six extreme value distributions, namely the Gumbel, Generalized Extreme Value (GEV), Generalized Logistic (GLO) and Generalized Pareto (GPA), the Lognormal (GNO) and the Pearson (PE3) distributions are evaluated. The method of L-moments is used in parameter estimation. Based on several goodness of fit tests and L-moment diagram test, the Generalized Pareto distribution and the Pearson distribution are found to be the best fitted distribution to represent the weekly and monthly maximum share returns in Malaysia stock market during the studied period, respectively.

  5. Cells anticipate periodic events

    NASA Astrophysics Data System (ADS)

    Nakagaki, Toshiyuki

    2009-03-01

    We show that an amoeboid organism can anticipate the timing of periodic events. The plasmodium of the true slime mold Physarum polycephalum moves rapidly under favourable conditions, but stops moving when transferred to less-favourable conditions. Plasmodia exposed to unfavourable conditions, presented in three consecutive pulses at constant intervals, reduced their locomotive speed in response to each episode. When subsequently subjected to favourable conditions, the plasmodia spontaneously reduced their locomotive speed at the time point when the next unfavourable episode would have occurred. This implied anticipation of impending environmental change. After this behaviour had been evoked several times, the locomotion of the plasmodia returned to normal; however, the anticipatory response could subsequently be induced by a single unfavourable pulse, implying recall of the memorized periodicity. We explored the mechanisms underlying these behaviours from a dynamical systems perspective. Our results hint at the cellular origins of primitive intelligence and imply that simple dynamics might be sufficient to explain its emergence.

  6. 26 CFR 1.6038-3 - Information returns required of certain United States persons with respect to controlled foreign...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... provided by Form 8865 and the accompanying instructions. The return must contain all of the information... provisions of § 1.761-2(b)(2)(ii). (f) Period covered by return. The information required under this section... filing the return; and (vi) Any other information that Form 8865 or its accompanying instructions...

  7. 26 CFR 1.6038-3 - Information returns required of certain United States persons with respect to controlled foreign...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... provided by Form 8865 and the accompanying instructions. The return must contain all of the information... provisions of § 1.761-2(b)(2)(ii). (f) Period covered by return. The information required under this section... filing the return; and (vi) Any other information that Form 8865 or its accompanying instructions...

  8. Expanding transplant options to patients over 50 years. Improved outcome after reduced intensity conditioning mismatched-unrelated donor transplantation for patients with acute myeloid leukemia: a report from the Acute Leukemia Working Party of the EBMT

    PubMed Central

    Savani, Bipin N.; Labopin, Myriam; Kröger, Nicolaus; Finke, Jürgen; Ehninger, Gerhard; Niederwieser, Dietger; Schwerdtfeger, Rainer; Bunjes, Donald; Glass, Bertram; Socié, Gerard; Ljungman, Per; Craddock, Charles; Baron, Frédéric; Ciceri, Fabio; Gorin, Norbert Claude; Esteve, Jordi; Schmid, Christoph; Giebel, Sebastian; Mohty, Mohamad; Nagler, Arnon

    2016-01-01

    The outcome of patients undergoing HLA-matched unrelated donor allogeneic hematopoietic cell transplantation following reduced-intensity conditioning or myeloablative regimens is reported to be equivalent; however, it is not known if the intensity of the conditioning impacts outcomes after mismatched unrelated donor transplantation for acute myeloid leukemia. Eight hundred and eighty three patients receiving reduced-intensity conditioning were compared with 1041 myeloablative conditioning regimen recipients in the setting of mismatched unrelated donor transplantation. The donor graft was HLA-matched at 9/10 in 872 (83.8%) and at 8/10 in 169 (16.2%) myeloablative conditioning recipients, while in the reduced-intensity conditioning cohort, 754 (85.4%) and 129 (14.6%) were matched at 9/10 and 8/10 loci, respectively. Myeloablative conditioning regimen recipients were younger, 70% being <50 years of age compared to only 30% in the reduced-intensity conditioning group (P=0.0001). Significantly, more patients had secondary acute myeloid leukemia (P=0.04) and Karnofsky Performance Status score <90% (P=0.02) in the reduced-intensity conditioning group. Patients <50 and ≥50 years were analyzed separately. On multivariate analysis and after adjusting for differences between the two groups, reduced-intensity conditioning in patients age ≥50 years was associated with higher overall survival (HR 0.78; P=0.01), leukemia-free survival (HR 0.82; P=0.05), and decreased non-relapse mortality (HR 0.73; P=0.03). Relapse incidence (HR 0.91; P=0.51) and chronic graft-versus-host disease (HR 1.31; P=0.11) were, however, not significantly different. In patients <50 years old, there were no statistically significant differences in overall survival, leukemia-free survival, relapse incidence, non-relapse mortality, and chronic graft-versus-host-disease between the groups. Our study shows no significant outcome differences in patients younger than 50 years receiving reduced-intensity vs

  9. Expanding transplant options to patients over 50 years. Improved outcome after reduced intensity conditioning mismatched-unrelated donor transplantation for patients with acute myeloid leukemia: a report from the Acute Leukemia Working Party of the EBMT.

    PubMed

    Savani, Bipin N; Labopin, Myriam; Kröger, Nicolaus; Finke, Jürgen; Ehninger, Gerhard; Niederwieser, Dietger; Schwerdtfeger, Rainer; Bunjes, Donald; Glass, Bertram; Socié, Gerard; Ljungman, Per; Craddock, Charles; Baron, Frédéric; Ciceri, Fabio; Gorin, Norbert Claude; Esteve, Jordi; Schmid, Christoph; Giebel, Sebastian; Mohty, Mohamad; Nagler, Arnon

    2016-06-01

    The outcome of patients undergoing HLA-matched unrelated donor allogeneic hematopoietic cell transplantation following reduced-intensity conditioning or myeloablative regimens is reported to be equivalent; however, it is not known if the intensity of the conditioning impacts outcomes after mismatched unrelated donor transplantation for acute myeloid leukemia. Eight hundred and eighty three patients receiving reduced-intensity conditioning were compared with 1041 myeloablative conditioning regimen recipients in the setting of mismatched unrelated donor transplantation. The donor graft was HLA-matched at 9/10 in 872 (83.8%) and at 8/10 in 169 (16.2%) myeloablative conditioning recipients, while in the reduced-intensity conditioning cohort, 754 (85.4%) and 129 (14.6%) were matched at 9/10 and 8/10 loci, respectively. Myeloablative conditioning regimen recipients were younger, 70% being <50 years of age compared to only 30% in the reduced-intensity conditioning group (P=0.0001). Significantly, more patients had secondary acute myeloid leukemia (P=0.04) and Karnofsky Performance Status score <90% (P=0.02) in the reduced-intensity conditioning group. Patients <50 and ≥50 years were analyzed separately. On multivariate analysis and after adjusting for differences between the two groups, reduced-intensity conditioning in patients age ≥50 years was associated with higher overall survival (HR 0.78; P=0.01), leukemia-free survival (HR 0.82; P=0.05), and decreased non-relapse mortality (HR 0.73; P=0.03). Relapse incidence (HR 0.91; P=0.51) and chronic graft-versus-host disease (HR 1.31; P=0.11) were, however, not significantly different. In patients <50 years old, there were no statistically significant differences in overall survival, leukemia-free survival, relapse incidence, non-relapse mortality, and chronic graft-versus-host-disease between the groups. Our study shows no significant outcome differences in patients younger than 50 years receiving reduced-intensity vs

  10. Measuring the Earnings Returns to Lifelong Learning in the UK

    ERIC Educational Resources Information Center

    Blanden, Jo; Buscha, Franz; Sturgis, Patrick; Urwin, Peter

    2012-01-01

    This paper examines the earnings returns to learning that takes place following the conventional "school-to-work" stage of the life-course. We operationalise such "lifelong learning" as the attainment of certified qualifications in adulthood, following the completion of the first period of continuous full-time education. Using data from the…

  11. Rates of Return to Educational Qualifications in the Transitional Economies.

    ERIC Educational Resources Information Center

    Newell, Andrew; Reilly, Barry

    1999-01-01

    Provides cross-country estimates on private rates of return to higher-education qualifications across various transitional economies spanning Central and Eastern Europe, Russia, and the former Soviet Union. Rates tend to rise in most transitional economies over the period considered. Rate variabilities help explain variabilities in wage…

  12. Gender Gap in Returns to Schooling in Palestine

    ERIC Educational Resources Information Center

    Daoud, Yousef

    2005-01-01

    This study provides estimates of the private returns to schooling in Palestine utilizing eight quarterly labor force surveys for 1999 and 2001. This period was chosen to investigate the differential impact of the Israeli closure policy on Palestinian male and female workers. Although gross enrollment ratios for males and females reveal little to…

  13. 48 CFR 52.247-66 - Returnable Cylinders.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... higher than 40 psia and having a circular cross section excluding a portable tank, multitank car tank, cargo tank or tank car. (b) Returnable cylinders shall remain the Contractor's property but shall be... within the loan period shall be charged a daily rental beginning with the first day after the loan...

  14. 48 CFR 52.247-66 - Returnable Cylinders.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... higher than 40 psia and having a circular cross section excluding a portable tank, multitank car tank, cargo tank or tank car. (b) Returnable cylinders shall remain the Contractor's property but shall be... within the loan period shall be charged a daily rental beginning with the first day after the loan...

  15. 48 CFR 52.247-66 - Returnable Cylinders.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... higher than 40 psia and having a circular cross section excluding a portable tank, multitank car tank, cargo tank or tank car. (b) Returnable cylinders shall remain the Contractor's property but shall be... within the loan period shall be charged a daily rental beginning with the first day after the loan...

  16. 48 CFR 52.247-66 - Returnable Cylinders.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... higher than 40 psia and having a circular cross section excluding a portable tank, multitank car tank, cargo tank or tank car. (b) Returnable cylinders shall remain the Contractor's property but shall be... within the loan period shall be charged a daily rental beginning with the first day after the loan...

  17. 48 CFR 52.247-66 - Returnable Cylinders.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... higher than 40 psia and having a circular cross section excluding a portable tank, multitank car tank, cargo tank or tank car. (b) Returnable cylinders shall remain the Contractor's property but shall be... within the loan period shall be charged a daily rental beginning with the first day after the loan...

  18. 18 CFR 154.403 - Periodic rate adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Periodic rate adjustments. 154.403 Section 154.403 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... recovery or return, the past period must be defined and the mechanism for the recovery or return must...

  19. Uncertain Educational Returns in a Developing Economy

    ERIC Educational Resources Information Center

    Mohapatra, Sandeep; Luckert, Martin K.

    2012-01-01

    This paper estimates the distribution of educational returns by gender for India. While previous studies focus on mean returns, the variance of educational returns has important implications for policy-making and micro-level decision making with respect to education. If the variance of educational returns is large, it can leave large sections of…

  20. 26 CFR 1.6001-2 - Returns.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Returns. 1.6001-2 Section 1.6001-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Information and Returns § 1.6001-2 Returns. For rules relating to returns required...

  1. 26 CFR 1.6001-2 - Returns.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Returns. 1.6001-2 Section 1.6001-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Information and Returns § 1.6001-2 Returns. For rules relating to returns required...

  2. 26 CFR 1.6001-2 - Returns.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 13 2011-04-01 2011-04-01 false Returns. 1.6001-2 Section 1.6001-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Information and Returns § 1.6001-2 Returns. For rules relating to returns required...

  3. 26 CFR 1.6001-2 - Returns.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Returns. 1.6001-2 Section 1.6001-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Information and Returns § 1.6001-2 Returns. For rules relating to returns required to be made...

  4. [A 50-year history of new drugs in Japan-the development and progress of anti-diabetic drugs and the epidemiological aspects of diabetes mellitus].

    PubMed

    Ozawa, Hikaru; Murai, Yuriko; Ozawa, Terutaka

    2003-01-01

    -meal hyperglycemia of Type 2 diabetes. Epalrestat (Ono Yakuhin Co., 1992) is effective for diabetic neuropathy by reducing the formation of sorbitol. These anti-DM drugs were recently studied and developed in Japan. 4) The Japan Diabetes Society proposed a guideline on diagnostic criteria and treatment of diabetes mellitus (DM) in 1999 and revised it in 2002. DM is classified as insulin-dependent DM (Type l) and non-insulin dependent DM (Type 2). Type 1, juvenile onset DM, requires insulin therapy to prevent ketosis and to sustain life. Treatment of type 2, adult onset DM, is recommended as a step-by-step method, starting with dietary-exercise therapy, followed by oral hypoglycemic drugs and then insulin therapy. DM patients with complications should have a therapy devised to match their circumstances. 5) Epidemiological aspects: The mortality rate of DM compared to the time of drug appearance was traced from 1920 to 2000. The curve goes down slowly in the time frame of World War II, but rises from 1950 to 1970. The elevation could not be suppressed by the appearance of SUs, BGs or improved insulin preparations. The curve runs flat from 1980 to 1990, which might be related to the use of purified insulin or human insulin therapy. The mortality rate of DM indicates that death by hyperglycemic coma and other deaths resulting from complications are excluded. The survey of the principal cause of death by DM during the period of 1981-1990 indicates that the death rate due to hyperglycemic coma is only 1.7% of the total deaths caused by DM. The effect of drug therapy on all of the death resulting from DM is not detected. Hospital visitation and admission rates of the DM patients have been recorded since 1952 in Japan. This curve is rising continuously, and none of the antidiabetic drugs has been able to suppress it. These data show that the antidiabetic drugs relieve DM symptoms through their effective hypoglycemic actions, but that they cannot suppress the mortality rate of DM. It is

  5. Return to activity following fasciotomy for chronic exertional compartment syndrome.

    PubMed

    Irion, Val; Magnussen, Robert A; Miller, Timothy L; Kaeding, Christopher C

    2014-10-01

    Diagnosis of chronic exertional compartment syndrome (CECS) is relatively rare but has been well documented in athletes. There are, however, few reports regarding return to athletic activity after surgery among elite-level athletes. We hypothesized that a majority of elite-level athletes would successfully return to their previous level of competition following fasciotomy for CECS. A retrospective chart review was performed to identify elite-level athletes (collegiate or professional sport participation) who underwent fasciotomy for CECS over a 3-year period. Data collected included sport or activity, treatment and surgical details, time away from sport/activity after surgery, and ability to return to prior level of activity. Six males and seven females were included in the analysis. Patient age ranged from 17 to 24 years with a mean of 19.7 years. Six patients underwent unilateral lower extremity compartment release, and seven underwent bilateral lower extremity compartment release. The anterior and lateral compartments alone were released in 11 patients (84.6%). Two patients (15.4%) underwent four-compartment releases. Eleven patients (84.6%) were able to return to their previous elite level of sport participation at a mean of 10.6 weeks following surgical fasciotomy. Patients who had four-compartment release had a more than 3.5 week average longer return to full sporting activities (p = 0.011). Fasciotomy is effective in allowing elite athletes with CECS to return to sport. PMID:24664450

  6. Periodized wavelets

    SciTech Connect

    Schlossnagle, G.; Restrepo, J.M.; Leaf, G.K.

    1993-12-01

    The properties of periodized Daubechies wavelets on [0,1] are detailed and contrasted against their counterparts which form a basis for L{sup 2}(R). Numerical examples illustrate the analytical estimates for convergence and demonstrate by comparison with Fourier spectral methods the superiority of wavelet projection methods for approximations. The analytical solution to inner products of periodized wavelets and their derivatives, which are known as connection coefficients, is presented, and several tabulated values are included.

  7. Heat Pipe Blocks Return Flow

    NASA Technical Reports Server (NTRS)

    Eninger, J. E.

    1982-01-01

    Metal-foil reed valve in conventional slab-wick heat pipe limits heat flow to one direction only. With sink warmer than source, reed is forced closed and fluid returns to source side through annular transfer wick. When this occurs, wick slab on sink side of valve dries out and heat pipe ceases to conduct heat.

  8. Return to the Red Planet

    NASA Technical Reports Server (NTRS)

    Lee, W.

    1996-01-01

    In November 1996, NASA and the Jet Propulsion Laboratory will begin America's return to Mars after a 20-year absence by launching the Mars Global Surveyor (MGS) spacecraft. This mission will usher in a new and exciting era of scientific missions to study the red planet.

  9. Return to the Social Studies.

    ERIC Educational Resources Information Center

    Consuela, Sister Mary

    In this speech, a plea is made to return content to the social studies. Content is seen as essential to cognitive and affective learning. Although the author feels that the introduction of behavioral objectives is a significant development of the various social studies projects, it is meaningless unless it is related to content. Clearly stated…

  10. Comet coma sample return instrument

    NASA Technical Reports Server (NTRS)

    Albee, A. L.; Brownlee, Don E.; Burnett, Donald S.; Tsou, Peter; Uesugi, K. T.

    1994-01-01

    The sample collection technology and instrument concept for the Sample of Comet Coma Earth Return Mission (SOCCER) are described. The scientific goals of this Flyby Sample Return are to return to coma dust and volatile samples from a known comet source, which will permit accurate elemental and isotopic measurements for thousands of individual solid particles and volatiles, detailed analysis of the dust structure, morphology, and mineralogy of the intact samples, and identification of the biogenic elements or compounds in the solid and volatile samples. Having these intact samples, morphologic, petrographic, and phase structural features can be determined. Information on dust particle size, shape, and density can be ascertained by analyzing penetration holes and tracks in the capture medium. Time and spatial data of dust capture will provide understanding of the flux dynamics of the coma and the jets. Additional information will include the identification of cosmic ray tracks in the cometary grains, which can provide a particle's process history and perhaps even the age of the comet. The measurements will be made with the same equipment used for studying micrometeorites for decades past; hence, the results can be directly compared without extrapolation or modification. The data will provide a powerful and direct technique for comparing the cometary samples with all known types of meteorites and interplanetary dust. This sample collection system will provide the first sample return from a specifically identified primitive body and will allow, for the first time, a direct method of matching meteoritic materials captured on Earth with known parent bodies.

  11. Neurocognitive Performance: Returning to Competition

    ERIC Educational Resources Information Center

    McDaniel, Larry W.; McIntire, Kyle

    2010-01-01

    Athletes who suffer from concussions under report their symptoms in order to expedite their return to competition. Athletic trainers and coaches must be aware of what is going on with athletes, even if it means requiring them to refrain from competition. Ninety percent of concussions are minor and can be difficult to diagnosis. There is a lack of…

  12. Skin lesions in returning travellers.

    PubMed

    Korzeniewski, Krzysztof; Juszczak, Dariusz; Jerzemowski, Janusz

    2015-01-01

    Skin lesions, apart from diarrhoeas, fever of unknown origin, and respiratory tract infections belong to the most frequent medical problems in travellers returned from tropical and subtropical destinations, accounting more than 10% of reported cases. Most dermatoses have their clinical onset during travel, although some of them can occur after return. Travel-related dermatological problems can have a wide spectrum of clinical picture, from macular, popular or nodular rash, linear and migratory lesions, to plaques, vesicles, bullae, erosions or ulcers. Skin conditions in returning travellers may be of infectious and non-infectious aetiologies. Infectious lesions may be originally tropical (e.g. dengue, chikungunya, schistosomiasis, leishmaniasis, myiasis, tungiasis, loiasis), although the majority are cosmopolitan (arthropod bites, sunburns, allergic rashes). The evaluation of skin lesions depends on many factors, including immune status of patients, use of medicines, exposure on health hazards (fauna, flora, risky behaviours), as well as the time, duration and location of travel. As the number of travellers to tropical and subtropical destinations has been continuously rising, the number of skin illnesses has also been increasing. This means that specialists in travel medicine need to extend their knowledge of epidemiology, clinical features and diagnosis of travel-related health problems including skin lesions in returning travellers. PMID:26394319

  13. The Returns to Apprenticeship Training

    ERIC Educational Resources Information Center

    McIntosh, Steven

    2005-01-01

    This paper uses recent data from the UK Labour Force Survey to estimate the wage gains that individuals make on average if they complete an apprenticeship programme. The results suggest gains of around 5-7% for men, but no benefit for women. Further analysis extends the results by considering the returns by age group, by qualification obtained, by…

  14. The Returns to Community College

    ERIC Educational Resources Information Center

    Agan, Amanda Yvonne

    2013-01-01

    Almost half of postsecondary students are currently enrolled in community colleges. These institutions imply that even amongst students with the same degree outcome there is considerable heterogeneity in the path taken to get there. I estimate the life-cycle private and social returns to the different postsecondary paths and sequential decisions…

  15. Analysing Enterprise Returns on Training.

    ERIC Educational Resources Information Center

    Moy, Janelle; McDonald, Rod

    Recent Australian and overseas studies on evaluation of enterprises' return on training investment (ROTI) were reviewed to identify key issues in encouraging increased evaluation of training benefits by enterprises and successful approaches that may inform future "enterprise-friendly" studies of ROTI. It was concluded that more practical,…

  16. Facilitating Successful Re-Entries in the United States: Training and Development for Women Returners

    ERIC Educational Resources Information Center

    Greer, Tomika W.

    2013-01-01

    Women returners are women who leave the paid workforce for a period of time following the birth of their child(ren) and subsequently seek to return to paid employment. As women returners attempt to re-enter the workforce, many of them are in need of updating their skills or re-training in a new set of skills. In this study, the training and…

  17. 26 CFR 31.6071(a)-1 - Time for filing returns and other documents.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... it is made. (3) Information returns—(i) General rule. Each information return in respect of wages as... § 31.6011(a)-5(a) is filed as a final return for a period ending prior to December 31, the information... return required to be made under §§ 31.6011(a)-1 and 31.6011(a)-1T, in respect of the taxes imposed...

  18. Phobos Sample Return: Next Approach

    NASA Astrophysics Data System (ADS)

    Zelenyi, Lev; Martynov, Maxim; Zakharov, Alexander; Korablev, Oleg; Ivanov, Alexey; Karabadzak, George

    The Martian moons still remain a mystery after numerous studies by Mars orbiting spacecraft. Their study cover three major topics related to (1) Solar system in general (formation and evolution, origin of planetary satellites, origin and evolution of life); (2) small bodies (captured asteroid, or remnants of Mars formation, or reaccreted Mars ejecta); (3) Mars (formation and evolution of Mars; Mars ejecta at the satellites). As reviewed by Galimov [2010] most of the above questions require the sample return from the Martian moon, while some (e.g. the characterization of the organic matter) could be also answered by in situ experiments. There is the possibility to obtain the sample of Mars material by sampling Phobos: following to Chappaz et al. [2012] a 200-g sample could contain 10-7 g of Mars surface material launched during the past 1 mln years, or 5*10-5 g of Mars material launched during the past 10 mln years, or 5*1010 individual particles from Mars, quantities suitable for accurate laboratory analyses. The studies of Phobos have been of high priority in the Russian program on planetary research for many years. Phobos-88 mission consisted of two spacecraft (Phobos-1, Phobos-2) and aimed the approach to Phobos at 50 m and remote studies, and also the release of small landers (long-living stations DAS). This mission implemented the program incompletely. It was returned information about the Martian environment and atmosphere. The next profect Phobos Sample Return (Phobos-Grunt) initially planned in early 2000 has been delayed several times owing to budget difficulties; the spacecraft failed to leave NEO in 2011. The recovery of the science goals of this mission and the delivery of the samples of Phobos to Earth remain of highest priority for Russian scientific community. The next Phobos SR mission named Boomerang was postponed following the ExoMars cooperation, but is considered the next in the line of planetary exploration, suitable for launch around 2022. A

  19. The Genesis Solar Wind Sample Return Mission

    NASA Technical Reports Server (NTRS)

    Wiens, Roger C.; Burnett, Donald S.; Neugebauer, Marcia; Sasaki, Chester; Sevilla, Donald; Stansbery, Eileen; Clark, Ben; Smith, Nick; Oldham, Lloyd

    1990-01-01

    The Genesis spacecraft was launched on August 8 from Cape Canaveral on a journey to become the first spacecraft to return from interplanetary space. The fifth in NASA's line of low-cost Discovery-class missions, its goal is to collect samples of solar wind and return them to Earth for detailed isotopic and elemental analysis. The spacecraft is to collect solar wind for over two years, while circling the L1 point 1.5 million km sunward of the earth, before heading back for a capsule-style re-entry in September, 2004. After parachute deployment, a mid-air helicopter recovery will be used to avoid a hard landing. The mission has been in the planning stages for over ten years. Its cost, including development, mission operations, and sample analysis, is approximately $209M. The Genesis science team, headed by principal investigator Donald Burnett of Caltech, consists of approximately 20 co-investigators from universities and science centers around the country and internationally. The spacecraft consists of a relatively flat spacecraft bus containing most of the subsystem components, situated below a sample return capsule (SRC) which holds the solar-wind collection substrates and an electrostatic solar wind concentrator. Some of the collectors are exposed throughout the collection period, for a sample of bulk solar wind, while others are exposed only to certain solar wind regimes, or types of flow. Ion and electron spectrometers feed raw data to the spacecraft control and data-handling (C&DH) unit, which determines ion moments and electron flux geometries in real time. An algorithm is used to robotically decide between interstream (IS), coronal hole (CH), and coronal mass ejection (CME) regimes, and to control deployment of the proper arrays to sample these wind regimes independently. This is the first time such a solar-wind decision algorithm has been used on board a spacecraft.

  20. 26 CFR 1.6013-2 - Joint return after filing separate return.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Joint return after filing separate return. 1... filing separate return. (a) In general. (1) Where an individual has filed a separate return for a taxable... separate return of either spouse are to be taken into account in determining the extent to which the...

  1. 26 CFR 1.6013-2 - Joint return after filing separate return.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 13 2011-04-01 2011-04-01 false Joint return after filing separate return. 1.6013-2 Section 1.6013-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Tax Returns Or Statements § 1.6013-2 Joint return after filing separate return. (a) In general....

  2. 26 CFR 20.6075-1 - Returns; time for filing estate tax return.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 14 2011-04-01 2010-04-01 true Returns; time for filing estate tax return. 20.6075-1 Section 20.6075-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Administration § 20.6075-1 Returns; time for filing estate tax return. The estate tax return required by...

  3. 26 CFR 20.6075-1 - Returns; time for filing estate tax return.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 14 2010-04-01 2010-04-01 false Returns; time for filing estate tax return. 20.6075-1 Section 20.6075-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Administration § 20.6075-1 Returns; time for filing estate tax return. The estate tax return required by...

  4. Mars Double-Flyby Free Returns

    NASA Technical Reports Server (NTRS)

    Jesick, Mark

    2015-01-01

    A subset of Earth-originating Mars double-flyby ballistic trajectories is documented. The subset consists of those trajectories that, after the first Mars flyby, perform a half-revolution transfer with Mars before returning to Earth. This class of free returns is useful for both human and robotic Mars missions because of its low geocentric energy at departure and arrival, and because of its extended stay time in the vicinity of Mars. Ballistic opportunities are documented over Earth departure dates ranging from 2015 through 2100. The mission is viable over three or four consecutive Mars synodic periods and unavailable for the next four, with the pattern repeating approximately every 15 years. Over the remainder of the century, a minimum Earth departure hyperbolic excess speed of 3.16 km/s, a minimum Earth atmospheric entry speed of 11.47 km/s, and a minimum flight time of 904 days are observed. The algorithm used to construct these trajectories is presented along with several examples.

  5. [Predictors of return to work after inpatient cardiac rehabilitation under workers' compensation plan].

    PubMed

    Budde, H G; Keck, M

    2001-08-01

    Vocational reintegration is one of the major goals of cardiac rehabilitation. 70 % of blue-collar workers under 50 years of age resume their job after in-patient cardiac rehabilitation. 10 % are hindered to do so by cardiac problems. Specific measures exist that may facilitate work resumption. As these measures should be started as soon as possible there is a need for predictors of return to work which can be obtained easily and at an early stage. Subjects of this prospective study were 650 patients (10 % female) under 50 years of age who participated in an in-patient cardiac rehabilitation programme under the workers' pension insurance scheme. At the beginning of programme participation, problems in work resumption as expected by the patient and by his physician were obtained, as well as depression and anxiety scores (HADS-D). Physicians' and patients' expectations concerning problems in resuming work turn out to be significant predictors of the vocational situation of the male patients six months following medical rehabilitation. The depression score obtained at the outset of the programme is the only predictor of return to work in female patients. PMID:11505298

  6. Periodic cages.

    PubMed

    Diudea, Mircea V; Nagy, Csaba L; Silaghi-Dumitrescu, Ioan; Graovac, Ante; Janezic, Dusanka; Vikić-Topić, Drazen

    2005-01-01

    Various cages are constructed by using three types of caps: f-cap (derived from spherical fullerenes by deleting zones of various size), kf-cap (obtainable by cutting off the polar ring, of size k), and t-cap ("tubercule"-cap). Building ways are presented, some of them being possible isomerization routes in the real chemistry of fullerenes. Periodic cages with ((5,7)3) covering are modeled, and their constitutive typing enumeration is given. Spectral data revealed some electronic periodicity in fullerene clusters. Semiempirical and strain energy calculations complete their characterization. PMID:15807490

  7. Results of Primary Total Hip Arthroplasty Using 36 mm Femoral Heads on 1st Generation Highly Cross Linked Polyethylene in Patients 50 Years and Less with Minimum Five Year Follow-up

    PubMed Central

    Choi, Won-Kee; Kim, Hee-soo; Nam, Jun-Ho; Chae, Seung-Bum

    2016-01-01

    Purpose We evaluated the clinical and radiographic midterm results of primary total hip arthroplasty (THA) using a 36 mm diameter femoral head on 1st generation highly cross-linked polyethylene (HXLPE) in patients 50 years and less with minimum five year follow-up. Materials and Methods We retrospectively reviewed 31 patients (41 hips) aged 50 years and less underwent primary THA with a 36 mm diameter femoral head on HXLPE between 2004 and 2010. Clinical follow-ups included specific measurements like modified Harris hip scores (HHS) and Merle d'Aubigne and Postel score. For radiologic evaluations, together with position of acetabular cup at six weeks later of postoperation, we separately calculated the penentrations of femoral head into polyethylene liners during postoperation and one year later check-ups, and during one year later check-ups and final check-ups. Results There were no major complications except for one case of dislocation. Average modified HHS at final follow-up was 88 (81-98), and Merle d'Aubigne and Postel scores were more than 15. Mean acetabular cup inclination and anteversion were 45.81°(36.33°-54.91°) and 13.26°(6.72°-27.71°), respectively. Average femoral head penetration of steady-state wear rate determined using radiographs taken at one-year postoperatively and at latest follow-up was 0.042±0.001 mm/year. Conclusion Based on minimum 5 years clinical results, we think 36 mm metal head coupling with HXLPE as the good alternate articulation surface when planning THA for patients aged 50 years and less. PMID:27536648

  8. 27 CFR 26.112 - Returns for deferred payment of tax.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... payment of tax and filing the return will be the 14th day after the last day of the calendar quarter... 26 U.S.C. 7652 under the same Employer Identification Number as defined in 26 CFR 301.7701-12. (2... provided in paragraph (e) of this section. (3) Quarterly return period. Effective January 1, 2006,...

  9. Returns to Education in the Economic Transition: A Systematic Assessment Using Comparable Data

    ERIC Educational Resources Information Center

    Flabbi, Luca; Paternostro, Stefano; Tiongson, Erwin R.

    2008-01-01

    This paper studies a sample of economies in transition to verify the assertion that returns to schooling increase as an economy transitions to a market environment. This claim has been difficult to assess in the past as the empirical evidence so far has covered only a few countries over short time periods. A number of studies find that returns to…

  10. Changes in the Returns to Schooling 1991-2002: Evidence from the British Household Panel Survey

    ERIC Educational Resources Information Center

    McGuinness, Seamus; Bennett, Jessica

    2009-01-01

    The present paper uses British Household Panel Survey data from 1991 to 2002 to assess the extent to which labour market returns have been influenced by changes in the nature of educational supply. We find that whilst there have been substantial shifts in the returns to schooling over the period, these effects are much more pronounced for younger…

  11. Parents Returning to Work: Evaluation of Grant Recipient Outcomes 2004-05, 2005-06

    ERIC Educational Resources Information Center

    Ferrier, Fran; Kellock, Peter; Burke, Gerald

    2007-01-01

    The Parents Returning to Work Program (PRTW) is a Victorian government initiative which commenced in 2003. It provides grants to assist eligible parents who wish to return to paid employment after a period of caring for children to participate in training that will increase their work skills and job prospects. This evaluation aimed to review the…

  12. Ochratoxin A: 50 Years of Research

    PubMed Central

    Malir, Frantisek; Ostry, Vladimir; Pfohl-Leszkowicz, Annie; Malir, Jan; Toman, Jakub

    2016-01-01

    Since ochratoxin A (OTA) was discovered, it has been ubiquitous as a natural contaminant of moldy food and feed. The multiple toxic effects of OTA are a real threat for human beings and animal health. For example, OTA can cause porcine nephropathy but can also damage poultries. Humans exposed to OTA can develop (notably by inhalation in the development of acute renal failure within 24 h) a range of chronic disorders such as upper urothelial carcinoma. OTA plays the main role in the pathogenesis of some renal diseases including Balkan endemic nephropathy, kidney tumors occurring in certain endemic regions of the Balkan Peninsula, and chronic interstitial nephropathy occurring in Northern African countries and likely in other parts of the world. OTA leads to DNA adduct formation, which is known for its genotoxicity and carcinogenicity. The present article discusses how renal carcinogenicity and nephrotoxicity cause both oxidative stress and direct genotoxicity. Careful analyses of the data show that OTA carcinogenic effects are due to combined direct and indirect mechanisms (e.g., genotoxicity, oxidative stress, epigenetic factors). Altogether this provides strong evidence that OTA carcinogenicity can also occur in humans. PMID:27384585

  13. Over 50 Years of Fibrinogen Concentrate.

    PubMed

    Costa-Filho, Rubens; Hochleitner, Gerald; Wendt, Michael; Teruya, Alexandre; Spahn, Donat R

    2016-03-01

    March 2013 represented the 50th anniversary of the first license granted for a fibrinogen concentrate. In this review, we look at the history of bleeding management that led to the development of fibrinogen concentrate, discuss its current use, and consider future developments for this product. PMID:26294722

  14. Over 50 Years of Fibrinogen Concentrate

    PubMed Central

    Hochleitner, Gerald; Wendt, Michael; Teruya, Alexandre; Spahn, Donat R.

    2015-01-01

    March 2013 represented the 50th anniversary of the first license granted for a fibrinogen concentrate. In this review, we look at the history of bleeding management that led to the development of fibrinogen concentrate, discuss its current use, and consider future developments for this product. PMID:26294722

  15. The First 50 Years of Electronic Watermarking

    NASA Astrophysics Data System (ADS)

    Cox, Ingemar J.; Miller, Matt L.

    2002-12-01

    Electronic watermarking can be traced back as far as 1954. The last 10 years has seen considerable interest in digital watermarking, due, in large part, to concerns about illegal piracy of copyrighted content. In this paper, we consider the following questions: is the interest warranted? What are the commercial applications of the technology? What scientific progress has been made in the last 10 years? What are the most exciting areas for research? And where might the next 10 years take us? In our opinion, the interest in watermarking is appropriate. However, we expect that copyright applications will be overshadowed by applications such as broadcast monitoring, authentication, and tracking content distributed within corporations. We further see a variety of applications emerging that add value to media, such as annotation and linking content to the Web. These latter applications may turn out to be the most compelling. Considerable progress has been made toward enabling these applications—perceptual modelling, security threats and countermeasures, and the development of a bag of tricks for efficient implementations. Further progress is needed in methods for handling geometric and temporal distortions. We expect other exciting developments to arise from research in informed watermarking.

  16. Oscillator Phase Noise: A 50-Year Review.

    PubMed

    Leeson, David B

    2016-08-01

    Fifty years ago emerging requirements in oscillator applications led to the 1964 IEEE-NASA Symposium on Short-term Frequency Stability. Following that, IEEE Technical Committee 14.7 was established to unify time- and frequency-domain definitions of frequency stability. I had the good fortune to participate and contribute as a member of the symposium program committee and the IEEE committee. This paper is a personal retrospective of events that are said to have shaped our field: the 1964 Symposium, the 1966 Proc. IEEE special issue on frequency stability we edited (with comments on my oscillator-model paper), and our 1971 paper, "Characterization of Frequency Stability," written as a basis for IEEE STD 1139. PMID:27164585

  17. Synthesis of allocolchicinoids: a 50 year journey

    NASA Astrophysics Data System (ADS)

    Sitnikov, N. S.; Fedorov, A. Yu

    2013-05-01

    Published data on the stereo- and enantioselective synthesis of allocolchicinoids, which are of interest as antitumour agents, are summarized. The stereochemistry of these compounds is described. Two key approaches to their preparation are considered, namely, the synthesis from natural colchicine and total synthesis from commercially available reagents. Various total syntheses of N-acetylcolchicinol are performed using biaryl oxidative and reductive coupling, cyclopropanation-ring expansion and Nicholas reaction. The synthetic routes to allocolchicine are based on Diels-Alder cycloaddition, combination of metathesis and Diels-Alder reaction and direct catalytic CH-arylation. Analogues of the colchicine site ligands incorporating heteroaromatic rings are briefly considered; their structural features and methods of synthesis are discussed. The bibliography includes 144 references.

  18. Systemic lupus erythematosus in 50 year olds.

    PubMed Central

    Domenech, I.; Aydintug, O.; Cervera, R.; Khamashta, M.; Jedryka-Goral, A.; Vianna, J. L.; Hughes, G. R.

    1992-01-01

    We compared the clinical and serological characteristics of 15 patients with onset of systemic lupus erythematosus after the age of 50 with those of 232 younger patients. The sex distribution was similar in both groups. All 15 patients were Caucasian. Autoimmune thyroiditis was found in 20% of the elderly patients. Initial manifestations, which presented more frequently in the older group, included thrombocytopenia (P < 0.05), sicca syndrome (P < 0.01) and cardiomyopathy (P < 0.005), whereas butterfly rash (P < 0.05) presented more frequently in the younger group. Analysis of cumulative clinical symptoms showed that butterfly rash (P < 0.05) and livedo reticularis (P < 0.05) were less frequent in the elderly. However, this group presented a significantly increased incidence of sicca syndrome (P < 0.005) and cardiomyopathy (P < 0.005). Antibodies to double-stranded DNA tended to occur less frequently in older patients (P < 0.05). PMID:1437923

  19. Ochratoxin A: 50 Years of Research.

    PubMed

    Malir, Frantisek; Ostry, Vladimir; Pfohl-Leszkowicz, Annie; Malir, Jan; Toman, Jakub

    2016-01-01

    Since ochratoxin A (OTA) was discovered, it has been ubiquitous as a natural contaminant of moldy food and feed. The multiple toxic effects of OTA are a real threat for human beings and animal health. For example, OTA can cause porcine nephropathy but can also damage poultries. Humans exposed to OTA can develop (notably by inhalation in the development of acute renal failure within 24 h) a range of chronic disorders such as upper urothelial carcinoma. OTA plays the main role in the pathogenesis of some renal diseases including Balkan endemic nephropathy, kidney tumors occurring in certain endemic regions of the Balkan Peninsula, and chronic interstitial nephropathy occurring in Northern African countries and likely in other parts of the world. OTA leads to DNA adduct formation, which is known for its genotoxicity and carcinogenicity. The present article discusses how renal carcinogenicity and nephrotoxicity cause both oxidative stress and direct genotoxicity. Careful analyses of the data show that OTA carcinogenic effects are due to combined direct and indirect mechanisms (e.g., genotoxicity, oxidative stress, epigenetic factors). Altogether this provides strong evidence that OTA carcinogenicity can also occur in humans. PMID:27384585

  20. Environmental health physics: 50 years of progress.

    PubMed

    Moeller, Dade W

    2005-06-01

    Environmental health physics is an interdisciplinary field, involving study of the release, transport, and fate of radioactive material in the environment. Further, it addresses the interaction of humans with radioactive materials within the ambient (outdoor) environment and with the environments associated with modern technology and lifestyles. It also involves both naturally occurring and artificially produced radionuclides with the former generally being by far the highest source of exposure. In fact, doses from naturally occurring radionuclides are increasingly being used as a benchmark for the establishment of dose rate limits for people. Because of the pioneering work of early environmental health physicists, models exist today that can be used to assess the potential impacts of new nuclear facilities prior to their operation. In fact, these people represent the branch of the health physics profession who conducted environmental monitoring programs and performed the associated research studies that led to the identification of the principal radionuclides of interest, the major pathways and mechanisms through which they expose people, and the doses that may result from radioactive materials in the natural and technologically enhanced environments. One of their most important contributions was the identification and quantification of many of the key parameters that serve as input to such models. Monitoring of nuclear weapons development facilities used during and after World War II was the initial stimulus for the establishment of environmental health physics programs. Thereafter, these programs were expanded both nationally and globally, as a result of the atmospheric weapons testing programs of nations such as France, the People's Republic of China, the former Soviet Union, the United Kingdom, and the United States. Additional stimuli were provided by the development of the commercial nuclear power industry. Current environmental programs, particularly within the U.S., focus on decontamination and decommissioning of dormant facilities from these earlier defense and commercial programs. The range of the environmental health physics aspects of these activities is the subject of this paper. Presented at the end of the paper is a summary of some of the more important lessons that have been learned. As will be noted, this is an exciting field that will present challenges to health physicists for years to come. PMID:15891461

  1. Environmental health physics-50 years of progress.

    PubMed

    Moeller, Dade W

    2004-10-01

    Environmental health physics is an interdisciplinary field, involving study of the release, transport, and fate of radioactive material in the environment. Further, it addresses the interaction of humans with radioactive materials within the ambient (outdoor) environment and with the environments associated with modern technology and lifestyles. It also involves both naturally occurring and artificially produced radionuclides with the former generally being by far the highest source of exposure. In fact, doses from naturally occurring radionuclides are increasingly being used as a benchmark for the establishment of dose rate limits for people. Because of the pioneering work of early environmental health physicists, models exist today that can be used to assess the potential impacts of new nuclear facilities prior to their operation. In fact, these people represent the branch of the health physics profession who conducted environmental monitoring programs and performed the associated research studies that led to the identification of the principal radionuclides of interest, the major pathways and mechanisms through which they expose people, and the doses that may result from radioactive materials in the natural and technologically enhanced environments. One of their most important contributions was the identification and quantification of many of the key parameters that serve as input to such models. Monitoring of nuclear weapons development facilities used during and after World War II was the initial stimulus for the establishment of environmental health physics programs. Thereafter, these programs were expanded both nationally and globally, as a result of the atmospheric weapons testing programs of nations such as France, the People's Republic of China, the former Soviet Union, the United Kingdom, and the United States. Additional stimuli were provided by the development of the commercial nuclear power industry. Current environmental programs, particularly within the U.S., focus on decontamination and decommissioning of dormant facilities from these earlier defense and commercial programs. The range of the environmental health physics aspects of these activities is the subject of this paper. Presented at the end of the paper is a summary of some of the more important lessons that have been learned. As will be noted, this is an exciting field that will present challenges to health physicists for years to come. PMID:15359181

  2. Plus 50: Year One Evaluation Report

    ERIC Educational Resources Information Center

    American Association of Community Colleges (NJ1), 2009

    2009-01-01

    The American Association of Community Colleges' (AACC) Plus 50 Initiative is a three-year initiative launched in June 2008 and funded by The Atlantic Philanthropies. It was created to support a pilot group of two-year institutions to develop or expand campus programs that engage plus 50 learners. The initiative focuses on three types of…

  3. Lessons Drawn from Sputnik 50 Years Later

    ERIC Educational Resources Information Center

    Cavanagh, Sean

    2007-01-01

    Fifty years ago, with the Soviet Union's launch of the Sputnik satellite, millions of Americans found themselves peering anxiously into the night sky--and also looking inward, as they reconsidered previously cozy assumptions about their nation's technological and educational superiority. The 184-pound, unmanned aluminum beacon lasted just three…

  4. The Scientific Return of VLT Programmes

    NASA Astrophysics Data System (ADS)

    Sterzik, M.; Dumas, C.; Grothkopf, U.; Kaufer, A.; Leibundgut, B.; Marteau, S.; Meakins, S.; Patat, F.; Primas, F.; Rejkuba, M.; Romaniello, M.; Stoehr, F.; Tacconi-Garman, L.; Vera, I.

    2015-12-01

    An in-depth analysis of the publications from 8414 distinct scheduled VLT observing programmes between April 1999 and March 2015 (Periods 63 to 94) is presented. The productivity by mode (Visitor or Service Mode) and type (Normal and Large, Guaranteed Time, Target of Opportunity, Director's Discretionary Time) are examined through their publication records. We investigate how Service Mode rank classes impact the scientific return. Several results derive from this study: Large Programmes result in the highest productivity, whereas only about half of all scheduled observing programmes produce a refereed publication. Programmes that result in a publication yield on average two refereed papers. B rank class Service Mode Programmes appear to be slightly less productive. Follow-up studies will investigate in more detail the parameters that influence the productivity of the Observatory.

  5. Quantifying Stock Return Distributions in Financial Markets

    PubMed Central

    Botta, Federico; Moat, Helen Susannah; Stanley, H. Eugene; Preis, Tobias

    2015-01-01

    Being able to quantify the probability of large price changes in stock markets is of crucial importance in understanding financial crises that affect the lives of people worldwide. Large changes in stock market prices can arise abruptly, within a matter of minutes, or develop across much longer time scales. Here, we analyze a dataset comprising the stocks forming the Dow Jones Industrial Average at a second by second resolution in the period from January 2008 to July 2010 in order to quantify the distribution of changes in market prices at a range of time scales. We find that the tails of the distributions of logarithmic price changes, or returns, exhibit power law decays for time scales ranging from 300 seconds to 3600 seconds. For larger time scales, we find that the distributions tails exhibit exponential decay. Our findings may inform the development of models of market behavior across varying time scales. PMID:26327593

  6. Quantifying Stock Return Distributions in Financial Markets.

    PubMed

    Botta, Federico; Moat, Helen Susannah; Stanley, H Eugene; Preis, Tobias

    2015-01-01

    Being able to quantify the probability of large price changes in stock markets is of crucial importance in understanding financial crises that affect the lives of people worldwide. Large changes in stock market prices can arise abruptly, within a matter of minutes, or develop across much longer time scales. Here, we analyze a dataset comprising the stocks forming the Dow Jones Industrial Average at a second by second resolution in the period from January 2008 to July 2010 in order to quantify the distribution of changes in market prices at a range of time scales. We find that the tails of the distributions of logarithmic price changes, or returns, exhibit power law decays for time scales ranging from 300 seconds to 3600 seconds. For larger time scales, we find that the distributions tails exhibit exponential decay. Our findings may inform the development of models of market behavior across varying time scales. PMID:26327593

  7. Joint analysis of changes in temperature and precipitation on the Loess Plateau during the period 1961-2011

    NASA Astrophysics Data System (ADS)

    Miao, Chiyuan; Sun, Qiaohong; Duan, Qingyun; Wang, Yafeng

    2016-02-01

    The Loess Plateau is particularly sensitive to climate change owing to its fragile ecological environment and geographic features. Here, we present a comprehensive analysis of the joint probabilistic characteristics and tendencies for bivariate and trivariate precipitation and temperature indices across the plateau, based on copula theory. The results show that the southeast region of the plateau had a higher potential for flooding: the 10-year return levels for the number of days with heavy and very heavy precipitation (R10mm, R20mm) and for the maximum 5-day precipitation value (RX5day) were higher in this region. The northwest region of the plateau, however, had a higher potential for drought, as reflected in the high and increasing 10-year return levels for the number of consecutive dry days (CDD) and the number of days with low precipitation (R1mm). In a joint analysis of precipitation indices, large areas of the Loess Plateau showed a relatively high risk of concurrent extreme precipitation events. However, the risk of concurrent extreme wet and dry events did not increase over the past half century, as demonstrated by nonsignificant changes in the probability of concurrently long CDD and long consecutive wet days (CWD). A trivariate copula analysis showed that some grid locations in the southeast of the plateau had an increasing risk of extreme precipitation events occurring at a high frequency and a high intensity, and forming a large percentage of the annual precipitation. Joint analysis of precipitation and temperature indices showed that the risk of higher temperatures and longer spells of consecutive dry days had increased over the past 50 years in grid locations scattered in the northern and southern regions: there were negative trends in the bivariate return periods for warm days (TX90p) and CDD. In addition, there was a decreased probability of concurrent long spells of consecutive wet days and colder temperatures, as demonstrated by the positive

  8. Asteroid Return Mission Feasibility Study

    NASA Technical Reports Server (NTRS)

    Brophy, John R.; Gershman, Robert; Landau, Damon; Polk, James; Porter, Chris; Yeomans, Don; Allen, Carlton; Williams, Willie; Asphaug, Erik

    2011-01-01

    This paper describes an investigation into the technological feasibility of finding, characterizing, robotically capturing, and returning an entire Near-Earth Asteroid (NEA) to the International Space Station (ISS) for scientific investigation, evaluation of its resource potential, determination of its internal structure and other aspects important for planetary defense activities, and to serve as a testbed for human operations in the vicinity of an asteroid. Reasonable projections suggest that several dozen candidates NEAs in the size range of interest (approximately 2-m diameter) will be known before the end of the decade from which a suitable target could be selected. The conceptual mission objective is to return an approximately 10,000-kg asteroid to the ISS in a total flight time of approximately 5 years using a single Evolved Expendable Launch Vehicle. Preliminary calculations indicate that this could be accomplished using a solar electric propulsion (SEP) system with high-power Hall thrusters and a maximum power into the propulsion system of approximately 40 kW. The SEP system would be used to provide all of the post-launch delta V. The asteroid would have an unrestricted Earth return Planetary Protection categorization, and would be curated at the ISS where numerous scientific and resource utilization experiments would be conducted. Asteroid material brought to the ground would be curated at the NASA Johnson Space Center. This preliminary study identified several areas where additional work is required, but no show stoppers were identified for the approach that would return an entire 10,000-kg asteroid to the ISS in a mission that could be launched by the end of this decade.

  9. Comet nucleus sample return mission

    NASA Technical Reports Server (NTRS)

    1983-01-01

    A comet nucleus sample return mission in terms of its relevant science objectives, candidate mission concepts, key design/technology requirements, and programmatic issues is discussed. The primary objective was to collect a sample of undisturbed comet material from beneath the surface of an active comet and to preserve its chemical and, if possible, its physical integrity and return it to Earth in a minimally altered state. The secondary objectives are to: (1) characterize the comet to a level consistent with a rendezvous mission; (2) monitor the comet dynamics through perihelion and aphelion with a long lived lander; and (3) determine the subsurface properties of the nucleus in an area local to the sampled core. A set of candidate comets is discussed. The hazards which the spacecraft would encounter in the vicinity of the comet are also discussed. The encounter strategy, the sampling hardware, the thermal control of the pristine comet material during the return to Earth, and the flight performance of various spacecraft systems and the cost estimates of such a mission are presented.

  10. Tick size and stock returns

    NASA Astrophysics Data System (ADS)

    Onnela, Jukka-Pekka; Töyli, Juuso; Kaski, Kimmo

    2009-02-01

    Tick size is an important aspect of the micro-structural level organization of financial markets. It is the smallest institutionally allowed price increment, has a direct bearing on the bid-ask spread, influences the strategy of trading order placement in electronic markets, affects the price formation mechanism, and appears to be related to the long-term memory of volatility clustering. In this paper we investigate the impact of tick size on stock returns. We start with a simple simulation to demonstrate how continuous returns become distorted after confining the price to a discrete grid governed by the tick size. We then move on to a novel experimental set-up that combines decimalization pilot programs and cross-listed stocks in New York and Toronto. This allows us to observe a set of stocks traded simultaneously under two different ticks while holding all security-specific characteristics fixed. We then study the normality of the return distributions and carry out fits to the chosen distribution models. Our empirical findings are somewhat mixed and in some cases appear to challenge the simulation results.

  11. The Mars Sample Return Project.

    PubMed

    O'Neil, W J; Cazaux, C

    2000-01-01

    The Mars Sample Return (MSR) Project is underway. A 2003 mission to be launched on a Delta III Class vehicle and a 2005 mission launched on an Ariane 5 will culminate in carefully selected Mars samples arriving on Earth in 2008. NASA is the lead agency and will provide the Mars landed elements, namely, landers, rovers, and Mars ascent vehicles (MAVs). The French Space Agency CNES is the largest international partner and will provide for the joint NASA/CNES 2005 Mission the Ariane 5 launch and the Earth Return Mars Orbiter that will capture the sample canisters from the Mars parking orbits the MAVs place them in. The sample canisters will be returned to Earth aboard the CNES Orbiter in the Earth Entry Vehicles provided by NASA. Other national space agencies are also expected to participate in substantial roles. Italy is planning to provide a drill that will operate from the Landers to provide subsurface samples. Other experiments in addition to the MSR payload will also be carried on the Landers. This paper will present the current status of the design of the MSR missions and flight articles. PMID:11708368

  12. 26 CFR 301.6103(c)-1 - Disclosure of returns and return information to designee of taxpayer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 18 2014-04-01 2014-04-01 false Disclosure of returns and return information to... and Returns Returns and Records § 301.6103(c)-1 Disclosure of returns and return information to... Service to disclose a taxpayer's return or return information to such person or persons as the...

  13. 26 CFR 301.6103(c)-1 - Disclosure of returns and return information to designee of taxpayer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 18 2013-04-01 2013-04-01 false Disclosure of returns and return information to... and Returns Returns and Records § 301.6103(c)-1 Disclosure of returns and return information to... Service to disclose a taxpayer's return or return information to such person or persons as the...

  14. 26 CFR 301.6103(c)-1 - Disclosure of returns and return information to designee of taxpayer.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 18 2012-04-01 2012-04-01 false Disclosure of returns and return information to... and Returns Returns and Records § 301.6103(c)-1 Disclosure of returns and return information to... Service to disclose a taxpayer's return or return information to such person or persons as the...

  15. 26 CFR 301.6103(c)-1 - Disclosure of returns and return information to designee of taxpayer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Disclosure of returns and return information to... and Returns Returns and Records § 301.6103(c)-1 Disclosure of returns and return information to... Service to disclose a taxpayer's return or return information to such person or persons as the...

  16. The Gulliver sample return mission to Deimos

    NASA Astrophysics Data System (ADS)

    Britt, D. T.; Robinson, M.; Gulliver Team

    The Martian moon Deimos presents a unique opportunity for a sample return mission. Deimos is spectrally analogous to type D asteroids, which are thought to be composed of highly primitive carbonaceous material that originated in the outer asteroid belt. It also is in orbit around Mars and has been accumulating material ejected from the Martian surface ever since the earliest periods of Martian history, over 4.4 Gyrs ago. There are a number of factors that make sample return from Deimos extremely attractive. It is Better: Deimos is a repository for two kinds of extremely significant and scientifically exciting ancient samples: (1) Primitive spectral D-type material that may have accreted in the outer asteroid belt and Trojan swarm. This material samples the composition of solar nebula well outside the zone of terrestrial planets and provides a direct sample of primitive material so common past 3 AU but so uncommon in the meteorite collection. (2) Ancient Mars, which could include the full range of Martian crustal and upper mantle material from the early differentiation and crustal-forming epoch as well as samples from the era of high volatile flux, thick atmosphere, and possible surface water. The Martian material on Deimos would be dominated by ejecta from the ancient crust of Mars, delivered during the Noachian Period of basin-forming impacts and heavy bombardment. It is Closer: Compared to other primitive D-type asteroids, Deimos is by far the most accessible. Because of its orbit around Mars, Deimos is far closer than any other D asteroid. It is Safer: Deimos is also by far the safest small body for sample return yet imaged. It is an order of magnitude less rocky than Eros and the NEAR-Shoemaker mission succeeded in landing on Eros with a spacecraft not designed for landing and proximity maneuvering. Because of Viking imagery we already know a great deal about the surface roughness of Deimos. It is known to be very smooth and have moderate topography and

  17. Exploring the Processes of Self-Development Encountered by Adult Returners to Higher Education: A Lifespan Psychology Perspective

    ERIC Educational Resources Information Center

    Mercer, Jenny

    2010-01-01

    Evidence indicates that non-traditional adult returners describe returning to education as a period of self-development and growth. However, lifespan psychology perspectives also show that successful growth and change involves periods of conflict. This paper will explore both the nature of self-development and conflicts experienced by a sample of…

  18. Myeloma in patients younger than age 50 years presents with more favorable features and shows better survival: an analysis of 10 549 patients from the International Myeloma Working Group

    PubMed Central

    Durie, Brian G. M.; Bolejack, Vanessa; Turesson, Ingemar; Kyle, Robert A.; Blade, Joan; Fonseca, Rafael; Dimopoulos, Meletios; Shimizu, Kazuyuki; San Miguel, Jesus; Westin, Jan; Harousseau, Jean-Luc; Beksac, Meral; Boccadoro, Mario; Palumbo, Antonio; Barlogie, Bart; Shustik, Chaim; Cavo, Michele; Greipp, Philip R.; Joshua, Douglas; Attal, Michel; Sonneveld, Pieter; Crowley, John

    2008-01-01

    We analyzed the presenting features and survival in 1689 patients with multiple myeloma aged younger than 50 years compared with 8860 patients 50 years of age and older. Of the total 10 549 patients, 7765 received conventional therapy and 2784 received high-dose therapy. Young patients were more frequently male, had more favorable features such as low International Staging System (ISS) and Durie-Salmon stage as well as less frequently adverse prognostic factors including high C-reactive protein (CRP), low hemoglobin, increased serum creatinine, and poor performance status. Survival was significantly longer in young patients (median, 5.2 years vs 3.7 years; P < .001) both after conventional (median, 4.5 years vs 3.3 years; P < .001) or high-dose therapy (median, 7.5 years vs 5.7 years; P = .04). The 10-year survival rate was 19% after conventional therapy and 43% after high-dose therapy in young patients, and 8% and 29%, respectively, in older patients. Multivariate analysis revealed age as an independent risk factor during conventional therapy, but not after autologous transplantation. A total of 5 of the 10 independent risk factors identified for conventional therapy were also relevant for autologous transplantation. After adjusting for normal mortality, lower ISS stage and other favorable prognostic features seem to account for the significantly longer survival of young patients with multiple myeloma with age remaining a risk factor during conventional therapy. PMID:18268097

  19. Periodic Polymers

    NASA Astrophysics Data System (ADS)

    Thomas, Edwin

    2013-03-01

    Periodic polymers can be made by self assembly, directed self assembly and by photolithography. Such materials provide a versatile platform for 1, 2 and 3D periodic nano-micro scale composites with either dielectric or impedance contrast or both, and these can serve for example, as photonic and or phononic crystals for electromagnetic and elastic waves as well as mechanical frames/trusses. Compared to electromagnetic waves, elastic waves are both less complex (longitudinal modes in fluids) and more complex (longitudinal, transverse in-plane and transverse out-of-plane modes in solids). Engineering of the dispersion relation between wave frequency w and wave vector, k enables the opening of band gaps in the density of modes and detailed shaping of w(k). Band gaps can be opened by Bragg scattering, anti-crossing of bands and discrete shape resonances. Current interest is in our group focuses using design - modeling, fabrication and measurement of polymer-based periodic materials for applications as tunable optics and control of phonon flow. Several examples will be described including the design of structures for multispectral band gaps for elastic waves to alter the phonon density of states, the creation of block polymer and bicontinuous metal-carbon nanoframes for structures that are robust against ballistic projectiles and quasi-crystalline solid/fluid structures that can steer shock waves.

  20. Comet coma sample return via Giotto II

    NASA Technical Reports Server (NTRS)

    Tsou, P.; Brownlee, D. E.; Albee, A. L.

    1985-01-01

    A comet coma sample return is possible with a low-cost flyby mission. Collecting coma materials and returning them to earth can be accomplished in a free-return trajectory. Intact capture of coma dust, preserving the cometary dust mineralogy, is possible at low encounter speeds. Samples from a known cometary source can then be compared with the wealth of information on meteorites and interplanetary dust. Sample return via Giotto II is a unique, low-cost NASA/ESA cooperative opportunity. With ESA providing the Giotto spacecraft and payload and NASA the sample return capability, first-class science can be accomplished at a very low cost for both NASA and ESA. This paper focuses on the sample return aspects, including sample return objectives, sample collection techniques, experimental work to verify collection concepts, and some of the characteristics of the cometary targets for sample return.