Science.gov

Sample records for 51-l updates included

  1. The STS 51-L Crew

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The STS-51L crewmembers are: in the back row from left to right: Mission Specialist, Ellison S. Onizuka, Teacher in Space Participant Sharon Christa McAuliffe, Payload Specialist, Greg Jarvis and Mission Specialist, Judy Resnik. In the front row from left to right: Pilot Mike Smith, Commander, Dick Scobee and Mission Specialist, Ron McNair.

  2. Atmospheric environment for space shuttle (STS-51L) launch

    NASA Technical Reports Server (NTRS)

    Jasper, G. L.; Johnson, D. L.; Alexander, M.; Fichtl, G. H.; Batts, G. W.

    1986-01-01

    A summary is given of selected atmospheric conditions observed near Space Shuttle STS-51L launch time on January 28, 1986, at Kennedy Space Center, Florida. Values of ambient pressure, temperature, moisture, ground winds, visual observations (cloud), and winds aloft are included. The sequence of pre-launch Jimsphere measured vertical wind profiles is given. The final atmospheric tape, which consists of wind and thermodynamic parameters versus altitude, for STS-51L vehicle ascent has been constructed. The STS-51L ascent atmospheric data tape has been constructed by Marshall Space Flight Center's Atmospheric Sciences Division to provide an internally consistent data set for use in post flight performance assessments.

  3. 51-L Flight Crew Emergency Egress Training

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The STS-51L Challenger flight crew emergency egress training in the slide wire baskets. From left to right they are: Mission Specialist, Ronald McNair, Payload Specialist, Gregory Jarvis, Teacher in Space Participant, Christa McAuliffe. Directly behind them: Mission Specialist Judy Resnik and Mission Specialist, Ellison Onizuka.

  4. 51-L Challenger Crew in White Room

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Crew members of mission STS-51L stand in the White Room at Pad 39B following the end of the Terminal Countdown Demonstration Test (TCDT). From left to right they are: Teacher in Space Participant, Sharon 'Christa' McAuliffe, Payload Specialist, Gregory Jarvis, Mission Specialist, Judy Resnik, Commander Dick Scobee Mission Specialist, Ronald McNair, Pilot, Michael Smith and Mission Specialist, Ellison Onizuka

  5. View of the SRB recovery during STS 51-L investigation

    NASA Technical Reports Server (NTRS)

    1986-01-01

    View of the solid rocket boosters (SRB) recovery during STS 51-L investigation. Photos include school of fish swimming by portion of the SRB. Kennedy Space Center (KSC) alternative photo number is 108-KSC-386C-1921/3 (30363); Portion of the SRB is lowered onto the deck of the recovery ship. KSC alternative photo number is 108-KSC-386C-923/3 (30364).

  6. 51-L Challenger Crew Remains Transferred

    NASA Technical Reports Server (NTRS)

    1988-01-01

    The Challenger crewmember remains are being transferred from 7 hearse vehicles to a MAC C-141 transport plane at the Kennedy Space Center's Shuttle Landing Facility for transport to Dover Air Force Base, Delaware. The STS-51L crew consisted of: Mission Specialist, Ellison S. Onizuka, Teacher in Space Participant Sharon Christa McAuliffe, Payload Specialist, Greg Jarvis and Mission Specialist, Judy Resnik. In the front row from left to right: Pilot Mike Smith, Commander, Dick Scobee and Mission Specialist, Ron McNair.

  7. View of the SRB recovery during STS 51-L investigation

    NASA Technical Reports Server (NTRS)

    1986-01-01

    View of the solid rocket boosters (SRB) recovery during STS 51-L investigation. Photos include portion of the SRB against a black background. The Kennedy Space Center (KSC) alternate photo number is 108-KSC-386C-1923/6 (29994); A man on the recovery ship hoses down a piece of the SRB. The KSC alternative photo number is 108-KSC-386C-1922/3 (29995); Deep drone contact with a portion of the SRB. KSC alternative photo number is 108-KSC-386C-937/12 (29996); School of fish swim by portion of the SRB. KSC alternative photo number is 108-KSC-386C-937/18 (29997).

  8. Advances in pleural disease management including updated procedural coding.

    PubMed

    Haas, Andrew R; Sterman, Daniel H

    2014-08-01

    Over 1.5 million pleural effusions occur in the United States every year as a consequence of a variety of inflammatory, infectious, and malignant conditions. Although rarely fatal in isolation, pleural effusions are often a marker of a serious underlying medical condition and contribute to significant patient morbidity, quality-of-life reduction, and mortality. Pleural effusion management centers on pleural fluid drainage to relieve symptoms and to investigate pleural fluid accumulation etiology. Many recent studies have demonstrated important advances in pleural disease management approaches for a variety of pleural fluid etiologies, including malignant pleural effusion, complicated parapneumonic effusion and empyema, and chest tube size. The last decade has seen greater implementation of real-time imaging assistance for pleural effusion management and increasing use of smaller bore percutaneous chest tubes. This article will briefly review recent pleural effusion management literature and update the latest changes in common procedural terminology billing codes as reflected in the changing landscape of imaging use and percutaneous approaches to pleural disease management.

  9. STS 51-L crewmembers participate in emergency egress training

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Two members of the STS 51-L crew practice emergency egress from the Space Shuttle in JSC's mockup and integration laboratory. Sharon Christa McAuliffe, representing the Teacher in Space project as a payload specialist, prepares to swing from a hatch extension onto a cushion below. Astronaut Judith A. Resnik, one of the 51-L mission specialists, awaits her turn. They are using the full-fuselage trainer for the session.

  10. The International Project. 1992 Update. Including "Microfilming Projects Abroad."

    ERIC Educational Resources Information Center

    Rutimann, Hans

    This publication describes national and international book preservation programs, including: (l) the European Register of Microform Masters (EROMM), a cooperative effort in which the Commission on Preservation and Access is a partner; (2) national preservation programs in Germany, France, Ireland, Britain, Netherlands, Sweden, China, and Central…

  11. 77 FR 55439 - Vessel Traffic Service Updates, Including Establishment of Vessel Traffic Service Requirements...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-10

    ... SECURITY Coast Guard 33 CFR Part 161 RIN 1625-AB81 Vessel Traffic Service Updates, Including Establishment of Vessel Traffic Service Requirements for Port Arthur, TX and Expansion of VTS Special Operating... Guard proposes to revise and update the Vessel Traffic Service (VTS) regulations in 33 CFR part 161....

  12. 77 FR 64076 - Vessel Traffic Service Updates, Including Establishment of Vessel Traffic Service Requirements...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... SECURITY Coast Guard 33 CFR Part 161 RIN 1625-AB81 Vessel Traffic Service Updates, Including Establishment of Vessel Traffic Service Requirements for Port Arthur, Texas and Expansion of VTS Special Operating... 10, 2012 (77 FR 55439), which proposes to revise and update the Vessel Traffic Service regulations...

  13. Practical uses for ecdysteroids in mammals including humans: an update

    PubMed Central

    Lafont, R.; Dinan, L.

    2003-01-01

    Ecdysteroids are widely used as inducers for gene-switch systems based on insect ecdysteroid receptors and genes of interest placed under the control of ecdysteroid-response elements. We review here these systems, which are currently mainly used in vitro with cultured cells in order to analyse the role of a wide array of genes, but which are expected to represent the basis for future gene therapy strategies. Such developments raise several questions, which are addressed in detail. First, the metabolic fate of ecdysteroids in mammals, including humans, is only poorly known, and the rapid catabolism of ecdysteroids may impede their use as in vivo inducers. A second set of questions arose in fact much earlier with the pioneering “heterophylic” studies of Burdette in the early sixties on the pharmacological effects of ecdysteroids on mammals. These and subsequent studies showed a wide range of effects, most of them being beneficial for the organism (e.g. hypoglycaemic, hypocholesterolaemic, anabolic). These effects are reviewed and critically analysed, and some hypotheses are proposed to explain the putative mechanisms involved. All of these pharmacological effects have led to the development of a wide array of ecdysteroid-containing preparations, which are primarily used for their anabolic and/or “adaptogenic” properties on humans (or horses or dogs). In the same way, increasing numbers of patents have been deposited concerning various beneficial effects of ecdysteroids in many medical or cosmetic domains, which make ecdysteroids very attractive candidates for several practical uses. It may be questioned whether all these pharmacological actions are compatible with the development of ecdysteroid-inducible gene switches for gene therapy, and also if ecdysteroids should be classified among doping substances. Abbreviation: 20E 20-hydroxyecdysone 2d20E 2-deoxy-20-hydroxyecdysone 2dE 2-deoxyecdysone BAH bisacylhydrazine BmEcR Bombyx mori EcR CfEcR Choristoneura

  14. Official portrait of the STS 51-L crewmembers

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Official portrait of the STS 51-L crewmembers. In the back row (l.-r.) Mission specialist Ellison S. Onizuka, Teacher in Space Participant Sharon Christa McAuliffe, Payload Specialist Greg Jarvis and Mission specialist Judy Resnik. In the front row (l.-r.) Pilot Mike Smith, Commander Dick Scobee, and Mission specialist Ron McNair.

  15. President Ronald Reagan speaks at STS 51-L Memorial service

    NASA Technical Reports Server (NTRS)

    1986-01-01

    President Ronald Reagan tells a large turnout of JSC employees and family and friends of the 51-L crewmembers about their accomplishments and sacrifices during memorial services held following the Challenger accident at Kennedy Space Center (KSC).'They slipped the surly bonds of earth to touch the face of God' the President told the thousands gathered on the central mall at JSC.

  16. STS 51-L crewmembers briefed during training session

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Five members of the STS 51-L crew and a backup crewmember are briefed during a training session in JSC's Shuttle mockup and integration laboratory. From left to right are Astronauts Ellison S. Onizuka, mission specialist; Ronald E. McNair, mission specialist; Gregory Jarvis, Hughes payload specialist; Judith A. Resnik, mission specialist; Sharon Christa McAuliffe, citizen observer/payload specialist representing the Teacher in Space project. Barbara R. Morgan, backup to McAuliffe, is in the right foreground.

  17. Wreckage from the Shuttle mission 51-L mission retrieved from the Atlantic

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Wreckage from the Space Shuttle mission 51-L mission retrieved from the Atlantic Ocean by a flotilla of U.S. Coast Guard and U.S. Navy vessels was returned to the Trident Basin at Cape Canaveral Air Force Station aboard the U.S. Coast Guard cutter Dallas. Views include portion of the side hatch area on the crew compartment (015); views of tile work on portions of the underside of the orbiter (016-19).

  18. Operational Dataset Update Functionality Included in the NCAR Research Data Archive Management System

    NASA Astrophysics Data System (ADS)

    Ji, Z.; Worley, S. J.; Schuster, D. C.

    2011-12-01

    Growing complexity, volume, and reliance on operationally created datasets poses challenges to the centers tasked with archiving and curating this information. Past tools focused on data delivered via media, such as tape, or data downloaded by single dataset customized ftp scripting. Presently nearly all data are acquired via network interactions, which can happen many times per day. Prior archive management technologies do not scale to this new paradigm. The Research Data Archive Management System (RDAMS) was developed to meet this challenge and has been implemented to support archive management within the Research Data Archive (RDA) at the National Center for Atmospheric Research (NCAR). RDAMS is driven by open source based databases and utilities, and is designed to support the complete data archive cycle by fetching, interrogating, archiving, and providing long-term research data stewardship. A good example of RDAMS functionality is found in the utility developed to specifically manage operational dataset updates, and can be applied to any dataset that requires periodic updating. The RDAMS dataset update utility (DSUPDT) accomplishes four basic tasks: 1) contact and query a remote server to see if new or modified data are available, 2) move data from a remote host to a local system and verify data transfer integrity, 3) execute any required data processing steps including metadata harvesting, 4) archive data to local disk and backup media systems. To accomplish these tasks across a diverse variety of datasets, DSUPDT incorporates a broad base of functionality. For example, it can be configured to run according to many different data set requirements, handles multiple web protocols, automatically recovers from system outages at the remote or local site, can execute 3rd party data manipulation software, and accommodates irregular data delivery schedules. Currently over 150 RDA dataset products are configured to be under DSUPDT control, with datasets being updated

  19. Interventions for rosacea: abridged updated Cochrane systematic review including GRADE assessments.

    PubMed

    van Zuuren, E J; Fedorowicz, Z

    2015-09-01

    Rosacea is a common chronic facial dermatosis. This update of our Cochrane review on interventions for rosacea summarizes the evidence, including Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group assessments, of the effects of the currently available treatments. Searches included the following: Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, MEDLINE, EMBASE, LILACS and the Science Citation Index, and ongoing trials registries (July 2014). We included 106 randomized controlled trials (RCTs) with 13 631 participants, a more than 80% increase since the last update in 2011. Pooling of data was feasible for a few outcomes, for topical metronidazole and azelaic acid and both appeared to be more effective than placebo (moderate and high-quality evidence, respectively). Topical ivermectin was more effective than placebo based on two studies (high-quality evidence), and slightly more effective than metronidazole in one study. Brimonidine was more effective than vehicle in reducing erythema in rosacea (high-quality evidence). Ciclosporin ophthalmic emulsion was effective for ocular rosacea (low-quality evidence). For oral treatments there was moderate-quality evidence for the effectiveness of tetracycline based on two old studies, and high-quality evidence for doxycycline 40 mg compared with placebo according to physician assessments. One study at high risk of bias demonstrated equivalent effectiveness for azithromycin and doxycycline 100 mg. Minocycline 45 mg may be effective for papulopustular rosacea (low-quality evidence). Low-dose isotretinoin appeared to be slightly more effective than doxycycline 50-100 mg (high-quality evidence). Laser and light-based therapies for erythema in rosacea were effective (low-quality evidence). Further RCTs are required for ocular rosacea.

  20. STS 51-L Memorial Montage designed by Bill Corey of TGS

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The STS 51-L Memorial Montage designed by Bill Corey of TGS Technology. The montage contains portraits of each of the STS 51-L crewmembers, a view of the Challenger at liftoff, the mission patch and a statement which reads 'They slipped the surly bonds of earth to touch the face of God'. At the end of the statement is a bird flying.

  1. Official portrait Sharon Christa McAuliffe, STS 51-L Teacher in Space

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Official portrait Sharon Christa McAuliffe, STS 51-L Teacher in Space. She is wearing the blue Shuttle flight suit and is holding a small model of the Shuttle. There is an American flag in the background.

  2. 78 FR 51664 - Vessel Traffic Service Updates, Including Establishment of Vessel Traffic Service Requirements...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... and updating the Vessel Traffic Service (VTS) regulations in 33 CFR Part 161. The revision makes... and expands a VTS Special Area in Puget Sound, WA; adds the designated frequencies for the Maritime... definitions and references in Sailing Plan requirements. The changes made by this rule will align...

  3. Payload specialists in training for STS 51-L in mockup and integration lab

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Payload specialists in training for STS 51-L take a break in Shuttle emergency egress training at JSC's mockup and integration laboratory. Left to right are Gregory Jarvis of Hughes, Sharon Christa McAuliffe and Barbara Morgan of the Teacher in Space Project.

  4. An Updated Review of Interventions that Include Promotion of Physical Activity for Adult Men.

    PubMed

    Bottorff, Joan L; Seaton, Cherisse L; Johnson, Steve T; Caperchione, Cristina M; Oliffe, John L; More, Kimberly; Jaffer-Hirji, Haleema; Tillotson, Sherri M

    2015-06-01

    The marked disparity in life expectancy between men and women suggests men are a vulnerable group requiring targeted health promotion programs. As such, there is an increasing need for health promotion strategies that effectively engage men with their health and/or illness management. Programs that promote physical activity could significantly improve the health of men. Although George et al. (Sports Med 42(3):281, 30) reviewed physical activity programs involving adult males published between 1990 and 2010, developments in men's health have prompted the emergence of new sex- and gender-specific approaches targeting men. The purpose of this review was to: (1) extend and update the review undertaken by George et al. (Sports Med 42(3):281, 30) concerning the effectiveness of physical activity programs in males, and (2) evaluate the integration of gender-specific influences in the content, design, and delivery of men's health promotion programs. A search of MEDLINE, CINAHL, ScienceDirect, Web of Science, PsycINFO, the Cochrane Library, and the SPORTDiscus databases for articles published between January 2010 and August 2014 was conducted. In total, 35 studies, involving evaluations of 31 programs, were identified. Findings revealed that a variety of techniques and modes of delivery could effectively promote physical activity among men. Though the majority of programs were offered exclusively to men, 12 programs explicitly integrated gender-related influences in male-specific programs in ways that recognized men's interests and preferences. Innovations in male-only programs that focus on masculine ideals and gender influences to engage men in increasing their physical activity hold potential for informing strategies to promote other areas of men's health.

  5. 2016 Updated American Society of Clinical Oncology/Oncology Nursing Society Chemotherapy Administration Safety Standards, Including Standards for Pediatric Oncology.

    PubMed

    Neuss, Michael N; Gilmore, Terry R; Belderson, Kristin M; Billett, Amy L; Conti-Kalchik, Tara; Harvey, Brittany E; Hendricks, Carolyn; LeFebvre, Kristine B; Mangu, Pamela B; McNiff, Kristen; Olsen, MiKaela; Schulmeister, Lisa; Von Gehr, Ann; Polovich, Martha

    2016-12-01

    Purpose To update the ASCO/Oncology Nursing Society (ONS) Chemotherapy Administration Safety Standards and to highlight standards for pediatric oncology. Methods The ASCO/ONS Chemotherapy Administration Safety Standards were first published in 2009 and updated in 2011 to include inpatient settings. A subsequent 2013 revision expanded the standards to include the safe administration and management of oral chemotherapy. A joint ASCO/ONS workshop with stakeholder participation, including that of the Association of Pediatric Hematology Oncology Nurses and American Society of Pediatric Hematology/Oncology, was held on May 12, 2015, to review the 2013 standards. An extensive literature search was subsequently conducted, and public comments on the revised draft standards were solicited. Results The updated 2016 standards presented here include clarification and expansion of existing standards to include pediatric oncology and to introduce new standards: most notably, two-person verification of chemotherapy preparation processes, administration of vinca alkaloids via minibags in facilities in which intrathecal medications are administered, and labeling of medications dispensed from the health care setting to be taken by the patient at home. The standards were reordered and renumbered to align with the sequential processes of chemotherapy prescription, preparation, and administration. Several standards were separated into their respective components for clarity and to facilitate measurement of adherence to a standard. Conclusion As oncology practice has changed, so have chemotherapy administration safety standards. Advances in technology, cancer treatment, and education and training have prompted the need for periodic review and revision of the standards. Additional information is available at http://www.asco.org/chemo-standards .

  6. Updating RIGs: Including the Systematic Influence of Online Study on Student Evaluation of Teaching

    ERIC Educational Resources Information Center

    Palmer, Stuart; Smith, Calvin

    2013-01-01

    Based on student evaluation of teaching (SET) ratings from 1,432 units of study over a period of a year, representing 74,490 individual sets of ratings, and including a significant number of units offered in wholly online mode, we confirm the significant influence of class size, year level, and discipline area on at least some SET ratings. We also…

  7. Update on the Human Broad Tapeworm (Genus Diphyllobothrium), Including Clinical Relevance

    PubMed Central

    Scholz, Tomáš; Garcia, Hector H.; Kuchta, Roman; Wicht, Barbara

    2009-01-01

    Summary: Tapeworms (Cestoda) continue to be an important cause of morbidity in humans worldwide. Diphyllobothriosis, a human disease caused by tapeworms of the genus Diphyllobothrium, is the most important fish-borne zoonosis caused by a cestode parasite. Up to 20 million humans are estimated to be infected worldwide. Besides humans, definitive hosts of Diphyllobothrium include piscivorous birds and mammals, which represent a significant zoonotic reservoir. The second intermediate hosts include both freshwater and marine fish, especially anadromous species such as salmonids. The zoonosis occurs most commonly in countries where the consumption of raw or marinated fish is a frequent practice. Due to the increasing popularity of dishes utilizing uncooked fish, numerous cases of human infections have appeared recently, even in the most developed countries. As many as 14 valid species of Diphyllobothrium can cause human diphyllobothriosis, with D. latum and D. nihonkaiense being the most important pathogens. In this paper, all taxa from humans reported are reviewed, with brief information on their life history and their current distribution. Data on diagnostics, epidemiology, clinical relevance, and control of the disease are also summarized. The importance of reliable identification of human-infecting species with molecular tools (sequences of mitochondrial genes) as well as the necessity of epidemiological studies aimed at determining the sources of infections are pointed out. PMID:19136438

  8. STS 51-L crewmembers at Ellington AFB for training flight in T-38

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Assigned 51-L crewmembers and backup are pictured at Ellington Air Field following brief flights in NASA's T-38 jet trainers seen in the background. Sharon Christa McAuliffe (center right), payload specialist/citizen observer for the Teacher in Space Project, and Barbara R. Morgan (center left), her backup, are flanked by Astronauts Francis R. (Dick) Scobee (right), mission commander, and Michael J. Smith, pilot.

  9. Crewmembers of the STS 51-L mission at pre-launch breakfast

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Crew members of STS 51-L mission are seated for breakfast on launch morning in the Operations and Checkout Building prior to liftoff of the orbiter Challenger. Crew members are left to right: Mission specialist Ellison Onizuka; Payload specialist Christa McAuliffe; Pilot Michael J. Smith; Commander Francis R. (Dick) Scobee; Mission Specialist Judith A. Resnik; Mission specialist Ronald E. McNair; and Payload specialist Gregory B. Jarvis.

  10. STS-26 crewmembers pose for onboard portrait on middeck with 51L mementos

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 crewmembers, each wearing a red, white, or blue polo shirt, pose for onboard crew portrait on Discovery's, Orbiter Vehicle (OV) 103's, middeck with STS-51L crew portrait, its flight (crew) insignia, and the STS-26 flight (crew) insignia. Left to right are Mission Specialist (MS) David C. Hilmers, MS George D. Nelson, Commander Frederick H. Hauck, MS John M. Lounge, and Pilot Richard O. Covey (front). The crewmembers pose in front of the port side wall.

  11. Teacher in Space trainees undergo training for STS 51-L mission

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Teacher in Space trainees undergo training for STS 51-L mission. Sharon Christa McAuliffe, named as prime crew citizen observer, studies the console on the aft flight deck, which contains controls for the remote manipulator system (RMS) and other important functions (40508); Barbara R. Morgan (left), back-up observer, and McAuliffe are briefed by L.W. Lew on the Space Shuttle galley, located in the middeck (40509).

  12. Wreckage from the Shuttle mission 51-L mission retrieved from the Atlantic

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Wreckage from the Space Shuttle mission 51-L mission retrieved from the Atlantic Ocean by a flotilla of U.S. Coast Guard and U.S. Navy vessels was returned to the Trident Basin at Cape Canaveral Air Force Station aboard the U.S. Coast Guard cutter Dallas. Views tile work on portions of the underside of the orbiter (020-24); portion of the crew compartment (025).

  13. View of debris assembled at the Kennedy Space Center from STS 51-L

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Pieces of the external tank from the STS 51-L accident are assembled in a tent near the Logistics Facility at the Kennedy Space Center. Most of the pieces were recovered by the Coast Guard and Navy following the accident. The pieces were assembled so that the side which normally would face the Orbiter Challenger is in the center of the tent. The picture was taken from the right side of the rear of the tank facing toward the top.

  14. Portion of left hand SRB aft segment containing ET attach ring for 51-L

    NASA Technical Reports Server (NTRS)

    1986-01-01

    These two photographs show a portion of the left hand solid rocket booster (SRB) aft segment which contains the external tank (ET) attach ring for the 51-L mission resting on the ocean bottom in 210 feet of water approximately 23 miles east of the Kennedy Space Center (KSC). The photographs were take by the Deep Drone, a remotely controlled, unmanned U.S. Navy submersible. Photo 1 shows small fish below and to the left of the booster segment (10145); Photo two shows the opposite end of the segment. Visible from left are the clevis portion of the field joint and the external tank attach ring (10146).

  15. Crewmembers of the STS 51-L mission leave Operations and Checkout Building

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Crew members of STS 51-L mission walk out of the Operations and Checkout Building on their way to Pad 39B where they will board the Shuttle Challenger. Crew members are from front to back: Commander Francis R. (Dick) Scobee; Mission specialists Judith A. Resnik and Ronald E. McNair; Pilot Michael J. Smith; Payload specialist Christa McAuliffe; Mission Specialist Ellison Onizuka; and Payload specialist Gregory Jarvis. photo number is 108-KSC-386C-937/12 (29996); School of fish swim by portion of the SRB. KSC alternative photo number is 108-KSC-386C-937/18 (29997).

  16. UPDATE ON PEC ACTIVITIES INCLUDING NEW EVALUATION CRITERIA, THE APPLICATION COMPLETENESS CHECKLIST, AND STATUS OF THE WEBSITE DEVELOPMENT

    EPA Science Inventory

    US EPA's Pathogen Equivalency Committee (PEC) has updated the evaluation criteria it uses to make recommendations of equivalency (to processes acceptable under 40CFR503) on innovative or alternative sludge pathogen reduction processes. These criteria will be presented along with ...

  17. The classification and diagnostic algorithm for primary lymphatic dysplasia: an update from 2010 to include molecular findings.

    PubMed

    Connell, F C; Gordon, K; Brice, G; Keeley, V; Jeffery, S; Mortimer, P S; Mansour, S; Ostergaard, P

    2013-10-01

    Historically, primary lymphoedema was classified into just three categories depending on the age of onset of swelling; congenital, praecox and tarda. Developments in clinical phenotyping and identification of the genetic cause of some of these conditions have demonstrated that primary lymphoedema is highly heterogenous. In 2010, we introduced a new classification and diagnostic pathway as a clinical and research tool. This algorithm has been used to delineate specific primary lymphoedema phenotypes, facilitating the discovery of new causative genes. This article reviews the latest molecular findings and provides an updated version of the classification and diagnostic pathway based on this new knowledge.

  18. Initial Business Case Analysis of Two Integrated Heat Pump HVAC Systems for Near-Zero-Energy Homes - Update to Include Evaluation of Impact of Including a Humidifier Option

    SciTech Connect

    Baxter, Van D

    2007-02-01

    --A Stage 2 Scoping Assessment, ORNL/TM-2005/194 (Baxter 2005). The 2005 study report describes the HVAC options considered, the ranking criteria used, and the system rankings by priority. In 2006, the two top-ranked options from the 2005 study, air-source and ground-source versions of a centrally ducted integrated heat pump (IHP) system, were subjected to an initial business case study. The IHPs were subjected to a more rigorous hourly-based assessment of their performance potential compared to a baseline suite of equipment of legally minimum efficiency that provided the same heating, cooling, water heating, demand dehumidification, and ventilation services as the IHPs. Results were summarized in a project report, Initial Business Case Analysis of Two Integrated Heat Pump HVAC Systems for Near-Zero-Energy Homes, ORNL/TM-2006/130 (Baxter 2006a). The present report is an update to that document which summarizes results of an analysis of the impact of adding a humidifier to the HVAC system to maintain minimum levels of space relative humidity (RH) in winter. The space RH in winter has direct impact on occupant comfort and on control of dust mites, many types of disease bacteria, and 'dry air' electric shocks. Chapter 8 in ASHRAE's 2005 Handbook of Fundamentals (HOF) suggests a 30% lower limit on RH for indoor temperatures in the range of {approx}68-69F based on comfort (ASHRAE 2005). Table 3 in chapter 9 of the same reference suggests a 30-55% RH range for winter as established by a Canadian study of exposure limits for residential indoor environments (EHD 1987). Harriman, et al (2001) note that for RH levels of 35% or higher, electrostatic shocks are minimized and that dust mites cannot live at RH levels below 40%. They also indicate that many disease bacteria life spans are minimized when space RH is held within a 30-60% range. From the foregoing it is reasonable to assume that a winter space RH range of 30-40% would be an acceptable compromise between comfort

  19. Tardigrada of Ireland: a review of records and an updated checklist of species including a new addition to the Irish fauna

    PubMed Central

    DeMilio, Erica; Lawton, Colin; Marley, Nigel J.

    2016-01-01

    Abstract The phylum Tardigrada was not recorded in Ireland until the Clare Island Survey of 1909–1911, with only rare subsequent reports on Irish tardigrade species. In recent decades, significant taxonomic revision has occurred within Tardigrada. This has resulted in the need for a review of all known historical records from Ireland and Northern Ireland in order to produce an updated checklist of valid taxa. The new checklist includes fifty-one tardigrade species and subspecies including a new addition to the Irish fauna reported herein, Echiniscus quadrispinosus quadrispinosus Richters, 1902 from Newtown, Ballyvaughan, Co. Clare. PMID:27667947

  20. Tardigrada of Ireland: a review of records and an updated checklist of species including a new addition to the Irish fauna.

    PubMed

    DeMilio, Erica; Lawton, Colin; Marley, Nigel J

    2016-01-01

    The phylum Tardigrada was not recorded in Ireland until the Clare Island Survey of 1909-1911, with only rare subsequent reports on Irish tardigrade species. In recent decades, significant taxonomic revision has occurred within Tardigrada. This has resulted in the need for a review of all known historical records from Ireland and Northern Ireland in order to produce an updated checklist of valid taxa. The new checklist includes fifty-one tardigrade species and subspecies including a new addition to the Irish fauna reported herein, Echiniscus quadrispinosus quadrispinosus Richters, 1902 from Newtown, Ballyvaughan, Co. Clare.

  1. Planet Hunters Update: Many New Planet Candidates Identified by Citizen Scientists from Kepler Data, Including Several in the Habitable Zone

    NASA Astrophysics Data System (ADS)

    Schmitt, Joseph; Wang, Ji

    2013-07-01

    Since December, 2010, more than 250,000 public volunteers have searched through more than 19 million Kepler light curves hunting for transiting planets. The Kepler light curves are shown in 30 day sections, and with ~160,000 Kepler target stars, the users have contributed the equivalent of 180 years of work hours. This vetting process has resulted in over 40 new planet candidates and two new confirmed planets, including several not identified through the Kepler pipeline. Many of our candidate planets lie within their host star's habitable zone. We review the recent large release of new PH candidates in Wang et al. (2013), including one confirmed planet, and give preliminary results for our next PH candidate release.

  2. Update on medical and regulatory issues pertaining to compounded and FDA-approved drugs, including hormone therapy

    PubMed Central

    Pinkerton, JoAnn V.; Pickar, James H.

    2016-01-01

    Abstract Objective: We review the historical regulation of drug compounding, concerns about widespread use of non-Food and Drug Admiistration (FDA)-approved compounded bioidentical hormone therapies (CBHTs), which do not have proper labeling and warnings, and anticipated impact of the 2013 Drug Quality and Security Act (DQSA) on compounding. Methods: US government websites were searched for documents concerning drug compounding regulation and oversight from 1938 (passage of Federal Food, Drug, and Cosmetic Act [FDCA]) through 2014, including chronologies, Congressional testimony, FDA guidelines and enforcements, and reports. The FDCA and DQSA were reviewed. PubMed and Google were searched for articles on compounded drugs, including CBHT. Results: Congress explicitly granted the FDA limited oversight of compounded drugs in a 1997 amendment to the FDCA, but the FDA has encountered obstacles in exercising that authority. After 64 patient deaths and 750 adversely affected patients from the 2012 meningitis outbreak due to contaminated compounded steroid injections, Congress passed the DQSA, authorizing the FDA to create a voluntary registration for facilities that manufacture and distribute sterile compounded drugs in bulk and reinforcing FDCA regulations for traditional compounding. Given history and current environment, concerns remain about CBHT product regulation and their lack of safety and efficacy data. Conclusions: The DQSA and its reinforcement of §503A of the FDCA solidifies FDA authority to enforce FDCA provisions against compounders of CBHT. The new law may improve compliance and accreditation by the compounding industry; support state and FDA oversight; and prevent the distribution of misbranded, adulterated, or inconsistently compounded medications, and false and misleading claims, thus reducing public health risk. PMID:26418479

  3. Mosquitoes of the mangrove forests of India: Part 3--Andaman and Nicobar Islands, including an update on the mosquito fauna of the islands.

    PubMed

    Rajavel, A R; Natarajan, R

    2006-09-01

    ABSTRACT. Fifty-three mosquito species belonging to 20 subgenera and 18 genera--Aedes, Anopheles, Armigeres, Culex, Downsiomyia, Finlaya, Heizmannia, Kenknightia, Lorrainea, Lutzia, Ochlerotatus, Orthopodomyia, Rhinoskusea, Stegomyia, Toxorhynchites, Tripteroides, Uranotaenia, and Verrallina--were recorded in the mangroves of Andaman and Nicobar Islands, India, in collections made during May and June 2001. Larvae of 43 species were collected from different mangrove habitats. Together with collections made in nonmangrove areas, 83 species in 22 subgenera and 20 genera in total were recorded of which 33 species are new records for the Andaman and Nicobar Islands. Rhinoskusea wardi, Fl. flavipennis, and Ve. consonensis are 3 new country records for India. Collections included topotype specimens of St. seampi. Together with species known from earlier records, the mosquito fauna of Andaman and Nicobar Islands is updated to 107 species in 23 subgenera and 24 genera.

  4. American Society of Clinical Oncology Clinical Practice Guideline Update on the Use of Pharmacologic Interventions Including Tamoxifen, Raloxifene, and Aromatase Inhibition for Breast Cancer Risk Reduction

    PubMed Central

    Visvanathan, Kala; Chlebowski, Rowan T.; Hurley, Patricia; Col, Nananda F.; Ropka, Mary; Collyar, Deborah; Morrow, Monica; Runowicz, Carolyn; Pritchard, Kathleen I.; Hagerty, Karen; Arun, Banu; Garber, Judy; Vogel, Victor G.; Wade, James L.; Brown, Powel; Cuzick, Jack; Kramer, Barnett S.; Lippman, Scott M.

    2009-01-01

    Purpose To update the 2002 American Society of Clinical Oncology guideline on pharmacologic interventions for breast cancer (BC) risk reduction. Methods A literature search identified relevant randomized trials published since 2002. Primary outcome of interest was BC incidence (invasive and noninvasive). Secondary outcomes included BC mortality, adverse events, and net health benefits. An expert panel reviewed the literature and developed updated consensus guidelines. Results Seventeen articles met inclusion criteria. In premenopausal women, tamoxifen for 5 years reduces the risk of BC for at least 10 years, particularly estrogen receptor (ER) –positive invasive tumors. Women ≤ 50 years of age experience fewer serious side effects. Vascular and vasomotor events do not persist post-treatment across all ages. In postmenopausal women, raloxifene and tamoxifen reduce the risk of ER-positive invasive BC with equal efficacy. Raloxifene is associated with a lower risk of thromboembolic disease, benign uterine conditions, and cataracts than tamoxifen in postmenopausal women. No evidence exists establishing whether a reduction in BC risk from either agent translates into reduced BC mortality. Recommendations In women at increased risk for BC, tamoxifen (20 mg/d for 5 years) may be offered to reduce the risk of invasive ER-positive BC, with benefits for at least 10 years. In postmenopausal women, raloxifene (60 mg/d for 5 years) may also be considered. Use of aromatase inhibitors, fenretinide, or other selective estrogen receptor modulators to lower BC risk is not recommended outside of a clinical trial. Discussion of risks and benefits of preventive agents by health providers is critical to patient decision making. PMID:19470930

  5. An updated checklist and key to the open-panicled species of Poa L. (Poaceae) in Peru including three new species, Poa ramoniana, Poa tayacajaensis, and Poa urubambensis.

    PubMed

    Sylvester, Steven P; Soreng, Robert J; Peterson, Paul M; Sylvester, Mitsy D P V

    2016-01-01

    We provide an updated checklist and key to the 30 Poa species with open panicles from Peru which includes previously circumscribed Dissanthelium and Aphanelytrum species, new taxon records, and three undescribed species. Poa compressa, Poa grisebachii, and Poa leioclada are recorded from Peru for the first time. A number of species are placed in synonymy: Poa carazensis, Poa ferreyrae and Poa tovarii are synonymized under the name Poa fibrifera; Poa adusta (tentatively) and Poa pilgeri are synonymized under Poa candamoana; Poa superata is synonymized under Poa grisebachii; and Poa paramoensis is synonymized under Poa huancavelicae. Included within this treatment are three new species, Poa ramoniana, Poa tayacajaensis and Poa urubambensis, which are described and illustrated. Poa ramoniana, found growing near lakes in high elevation Puna grasslands of Junín, is similar to a small form of Poa glaberrima, but differs in having rhizomes and growing to only 5 cm tall. Poa tayacajaensis, found from shrublands on Andean slopes of Huancavelica and Huánuco, bears similarities to Poa aequatoriensis but differs in having shorter lemmas which are pubescent between the veins, densely scabrous sheaths with smooth, glabrous throats, and shorter ligules. Poa urubambensis, a common element of the undisturbed Polylepis forest understory of the Cordillera Urubamba, Cusco, is distinct from all other members of open-panicled Poa's by having glabrous lemmas with a smooth and glabrous callus, and notably small anthers. The type material for the name Poa adusta is discussed and a lectotype is selected.

  6. An updated checklist and key to the open-panicled species of Poa L. (Poaceae) in Peru including three new species, Poa ramoniana, Poa tayacajaensis, and Poa urubambensis

    PubMed Central

    Sylvester, Steven P.; Soreng, Robert J.; Peterson, Paul M.; Sylvester, Mitsy D.P.V.

    2016-01-01

    Abstract We provide an updated checklist and key to the 30 Poa species with open panicles from Peru which includes previously circumscribed Dissanthelium and Aphanelytrum species, new taxon records, and three undescribed species. Poa compressa, Poa grisebachii, and Poa leioclada are recorded from Peru for the first time. A number of species are placed in synonymy: Poa carazensis, Poa ferreyrae and Poa tovarii are synonymized under the name Poa fibrifera; Poa adusta (tentatively) and Poa pilgeri are synonymized under Poa candamoana; Poa superata is synonymized under Poa grisebachii; and Poa paramoensis is synonymized under Poa huancavelicae. Included within this treatment are three new species, Poa ramoniana, Poa tayacajaensis and Poa urubambensis, which are described and illustrated. Poa ramoniana, found growing near lakes in high elevation Puna grasslands of Junín, is similar to a small form of Poa glaberrima, but differs in having rhizomes and growing to only 5 cm tall. Poa tayacajaensis, found from shrublands on Andean slopes of Huancavelica and Huánuco, bears similarities to Poa aequatoriensis but differs in having shorter lemmas which are pubescent between the veins, densely scabrous sheaths with smooth, glabrous throats, and shorter ligules. Poa urubambensis, a common element of the undisturbed Polylepis forest understory of the Cordillera Urubamba, Cusco, is distinct from all other members of open-panicled Poa’s by having glabrous lemmas with a smooth and glabrous callus, and notably small anthers. The type material for the name Poa adusta is discussed and a lectotype is selected. PMID:27489489

  7. Colombia Mi Pronostico Flood Application: Updating and Improving the Mi Pronostico Flood Web Application to Include an Assessment of Flood Risk

    NASA Technical Reports Server (NTRS)

    Rushley, Stephanie; Carter, Matthew; Chiou, Charles; Farmer, Richard; Haywood, Kevin; Pototzky, Anthony, Jr.; White, Adam; Winker, Daniel

    2014-01-01

    Colombia is a country with highly variable terrain, from the Andes Mountains to plains and coastal areas, many of these areas are prone to flooding disasters. To identify these risk areas NASA's Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) was used to construct a digital elevation model (DEM) for the study region. The preliminary risk assessment was applied to a pilot study area, the La Mosca River basin. Precipitation data from the National Aeronautics and Space Administration (NASA) Tropical Rainfall Measuring Mission (TRMM)'s near-real-time rainfall products as well as precipitation data from the Instituto de Hidrologia, Meteorologia y Estudios Ambientales (the Institute of Hydrology, Meteorology and Environmental Studies, IDEAM) and stations in the La Mosca River Basin were used to create rainfall distribution maps for the region. Using the precipitation data and the ASTER DEM, the web application, Mi Pronóstico, run by IDEAM, was updated to include an interactive map which currently allows users to search for a location and view the vulnerability and current weather and flooding conditions. The geospatial information was linked to an early warning system in Mi Pronóstico that can alert the public of flood warnings and identify locations of nearby shelters.

  8. Global Aesthetics Consensus: Botulinum Toxin Type A—Evidence-Based Review, Emerging Concepts, and Consensus Recommendations for Aesthetic Use, Including Updates on Complications

    PubMed Central

    Signorini, Massimo; Liew, Steven; Trindade de Almeida, Ada R.; Wu, Yan; Vieira Braz, André; Fagien, Steven; Goodman, Greg J.; Monheit, Gary; Raspaldo, Hervé

    2016-01-01

    Background: Botulinum toxin type A injection remains the leading nonsurgical cosmetic procedure worldwide, with a high rate of efficacy and patient satisfaction. Methods: A multinational, multidisciplinary group of plastic surgeons and dermatologists convened the Global Aesthetics Consensus Group to develop updated consensus recommendations with a worldwide perspective for botulinum toxin and hyaluronic acid fillers. This publication on botulinum toxin type A considers advances in facial analysis, injection techniques, and avoidance and management of complications. Results: Use of botulinum toxin has evolved from the upper face to also encompass the lower face, neck, and midface. The Global Aesthetics Consensus Group emphasizes an integrative, diagnostic approach. Injection dosage and placement are based on analysis of target muscles in the context of adjacent ones and associated soft and hard tissues. The indication for selection of botulinum toxin as a primary intervention is that excessive muscular contraction is the primary etiology of the facial disharmony to be addressed. Global Aesthetics Consensus Group recommendations demonstrate a paradigm shift toward neuromodulation rather than paralysis, including lower dosing of the upper face, more frequent combination treatment with hyaluronic acid fillers, and intracutaneous injection where indicated to limit depth and degree of action. Conclusions: The accumulation of clinical evidence and experience with botulinum toxin has led to refinements in treatment planning and implementation. The Global Aesthetics Consensus Group advocates an etiology-driven, patient-tailored approach, to enable achievement of optimal efficacy and safety in patient populations that are rapidly diversifying with respect to ethnicity, gender, and age. CLINCAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V. PMID:26910696

  9. An updated check list of the Cochylina (Tortricidae, Tortricinae, Euliini) of North America north of Mexico including Greenland, with comments on classification and identification

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We present an updated list of the members of the subtribe Cochylina (Tortricidae) in North America north of Mexico. We summarize the proposed changes in the classification since about 1983. We propose revised status for two genera, Rolandylis Gibeaux, 1985 and Thyraylia Walsingham, 1897. We propose ...

  10. An Update on Methods for Revascularization and Expansion of the TASC Lesion Classification to Include Below-the-Knee Arteries: A Supplement to the Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)

    PubMed Central

    Jaff, *Michael R.; White, Christopher J.; Hiatt, William R.; Fowkes, Gerry R.; Dormandy, John; Razavi, Mahmood; Reekers, Jim

    2015-01-01

    The Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC) guidelines were last updated in 2007 (TASC II) and represented the collaboration of international vascular specialties involved in the management of patients with peripheral arterial disease (PAD). Since the publication of TASC II, there have been innovations in endovascular revascularization strategies for patients with PAD. The intent of this publication is to provide a complete anatomic lower limb TASC lesion classification, including the infrapopliteal segment, and an updated literature review of new endovascular techniques and practice patterns employed by vascular specialists today. PMID:26730266

  11. Update '98.

    ERIC Educational Resources Information Center

    Mock, Karen R.

    1998-01-01

    Updates cases and issues previously discussed in this regular column on human rights in Canada, including racism and anti-Semitism, laws on hate crimes, hate sites on the World Wide Web, the use of the "free speech" defense by hate groups, and legal challenges to antiracist groups by individuals criticized by them. (DSK)

  12. Diesel Engine Technology Update

    DTIC Science & Technology

    1987-07-01

    AFWAL-TR-87-20 54 83-021-DET DIESEL ENGINE TECHNOLOGY UPDATE Kaupert, Andrew W., Lt. Col. USAFR Air Force Reserves Detroit Detachment 2 Ann Arbor, MI...nn AFR OH 45433-6563 63723F 3139 1 01 01 11. TITLE (Include Security Classification) DIESEL ENGINE TECHNOLOGY UPDATE 12. PERSONAL AUTHOR(S) Kaupert...methodology for technology prediction. The objective of the present report is to update the technology transfer/ 0 development status of diesel engine

  13. KEY COMPARISON: Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the NPL

    NASA Astrophysics Data System (ADS)

    Ratel, G.; Michotte, C.; Woods, M. J.

    2003-01-01

    Since 2001, four national metrology institutes (NMIs) have submitted four samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures, the most recent being that of the NPL (UK). The activities ranged from about 1 MBq to 8 MBq. The key comparison reference value (KCRV) has been recalculated to include the latest value and the degrees of equivalence between each equivalent activity measured in the SIR and the key comparison reference value (KCRV) have been calculated and the results are given in the form of a matrix. A graphical presentation is also given. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by Section II of the Consultative Committee for Ionizing Radiation (CCRI(II)), comparison identifier BIPM.RI(II)-K1.F-18, according to the provisions of the Mutual Recognition Arrangement (MRA).

  14. KEY COMPARISON: Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the CIEMAT

    NASA Astrophysics Data System (ADS)

    Ratel, G.; Michotte, C.; García-Toraño, E.; Los Arcos, J.-M.

    2004-01-01

    Since 2001, five national metrology institutes (NMIs) have submitted five samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), the most recent being that of the CIEMAT (Spain). The activities ranged from about 1 MBq to 18 MBq. The key comparison reference value (KCRV) has been recalculated to include the latest value and the degrees of equivalence between each equivalent activity measured in the SIR have been calculated and the results are given in the form of a matrix. A graphical presentation is also given for this key comparison with identifier BIPM.RI(II)-K1.F-18. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by Section II of the Consultative Committee for Ionizing Radiation (CCRI(II)), according to the provisions of the Mutual Recognition Arrangement (MRA).

  15. KEY COMPARISON: Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the PTB

    NASA Astrophysics Data System (ADS)

    Ratel, G.; Michotte, C.; Kossert, K.; Janßen, H.

    2006-01-01

    Since 2001, six national metrology institutes (NMIs) have submitted six samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), the most recent being that of the PTB (Germany). The activities ranged from about 1 MBq to 18 MBq. The key comparison reference value (KCRV) has been recalculated to include the latest value, with the agreement of the CCRI(II). The degrees of equivalence between each equivalent activity measured in the SIR have been recalculated and the results are given in the form of a matrix. A graphical presentation is also given for this key comparison with identifier BIPM.RI(II)-K1.F-18. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by Section II of the Consultative Committee for Ionizing Radiation (CCRI(II)), according to the provisions of the Mutual Recognition Arrangement (MRA).

  16. Updated mitochondrial phylogeny of Pteriomorph and Heterodont Bivalvia, including deep-sea chemosymbiotic Bathymodiolus mussels, vesicomyid clams and the thyasirid clam Conchocele cf. bisecta.

    PubMed

    Ozawa, Genki; Shimamura, Shigeru; Takaki, Yoshihiro; Yokobori, Shin-Ichi; Ohara, Yasuhiko; Takishita, Kiyotaka; Maruyama, Tadashi; Fujikura, Katsunori; Yoshida, Takao

    2017-02-01

    The mitochondrial genomes of bivalves have often been used for comparative genomics and for resolving phylogenetic relationships. More than 100 bivalve complete mitochondrial genomes have been sequenced to date. However, few mitochondrial genomes have been reported for deep-sea chemosymbiotic bivalves, which belong to the subclasses Pteriomorphia and Heterodonta. In the present study, we sequenced the mitochondrial genomes of eight deep-sea chemosymbiotic bivalve species: three species of Bathymodiolus mussels (B. japonicus, B. platifrons, and B. septemdierum), four species of vesicomyid clams (Abyssogena mariana, A. phaseoliformis, Isorropodon fossajaponicum, and Phreagena okutanii, all of which were formerly classified in the genus Calyptogena), and one species of thyasirid clam (Conchocele cf. bisecta). With a few exceptions, these mitochondrial genomes contained genes that are typical of metazoans: 13 protein-coding genes, two rRNA genes, and 22 tRNA genes. The major non-coding region with a high A+T content of each genome, which contained tandem repeats and hairpins, was hypothesized to function as a control region. The phylogenetic trees of Pteriomorphia and Heterodonta were reconstructed based on the concatenated sequences of 14 shared genes. Bathymodiolus formed a monophyletic clade with asymbiotic Mytilidae mussels, the vesicomyid clams formed a monophyly that was sister to the Veneridae, and C. cf. bisecta branched basally in the Heterodonta. It is known that the gene orders of mitochondrial genomes vary among bivalves. To examine whether gene order variation exhibits phylogenetic signals, tree topologies based on the minimum number of gene rearrangements were reconstructed for two clades (superfamily Tellinoidea, which includes the Psammobiidae, Semelidae, Solecurtidae, and Tellinidae; and the clade comprising the Myidae, Mactridae, Arcticidae, Vesicomyidae, and Veneridae) with high statistical support in sequence-based phylogenies. The resulting tree

  17. Energy savings for heat-island reduction strategies in Chicago and Houston (including updates for Baton Rouge, Sacramento, and Salt Lake City)

    SciTech Connect

    Konopacki, S.; Akbari, H.

    2002-02-28

    In 1997, the U.S. Environmental Protection Agency (EPA) established the ''Heat Island Reduction Initiative'' to quantify the potential benefits of Heat-Island Reduction (HIR) strategies (i.e., shade trees, reflective roofs, reflective pavements and urban vegetation) to reduce cooling-energy use in buildings, lower the ambient air temperature and improve urban air quality in cities, and reduce CO2 emissions from power plants. Under this initiative, the Urban Heat Island Pilot Project (UHIPP) was created with the objective of investigating the potential of HIR strategies in residential and commercial buildings in three initial UHIPP cities: Baton Rouge, LA; Sacramento, CA; and Salt Lake City, UT. Later two other cities, Chicago, IL and Houston, TX were added to the UHIPP. In an earlier report we summarized our efforts to calculate the annual energy savings, peak power avoidance, and annual CO2 reduction obtainable from the introduction of HIR strategies in the initial three cities. This report summarizes the results of our study for Chicago and Houston. In this analysis, we focused on three building types that offer the highest potential savings: single-family residence, office and retail store. Each building type was characterized in detail by vintage and system type (i.e., old and new building constructions, and gas and electric heat). We used the prototypical building characteristics developed earlier for each building type and simulated the impact of HIR strategies on building cooling- and heating-energy use and peak power demand using the DOE-2.1E model. Our simulations included the impact of (1) strategically-placed shade trees near buildings [direct effect], (2) use of high-albedo roofing material on the building [direct effect], (3) urban reforestation with high-albedo pavements and building surfaces [indirect effect] and (4) combined strategies 1, 2, and 3 [direct and indirect effects]. We then estimated the total roof area of air-conditioned buildings in

  18. Bacterial type B RNase P: functional characterization of the L5.1-L15.1 tertiary contact and antisense inhibition.

    PubMed

    Walczyk, Dennis; Willkomm, Dagmar K; Hartmann, Roland K

    2016-11-01

    Ribonuclease P is the ubiquitous endonuclease that generates the mature 5'-ends of precursor tRNAs. In bacteria, the enzyme is composed of a catalytic RNA (∼400 nucleotides) and a small essential protein subunit (∼13 kDa). Most bacterial RNase P RNAs (P RNAs) belong to the architectural type A; type B RNase P RNA is confined to the low-G+C Gram-positive bacteria. Here we demonstrate that the L5.1-L15.1 intradomain contact in the catalytic domain of the prototypic type B RNase P RNA of Bacillus subtilis is crucial for adopting a compact functional conformation: Disruption of the L5.1-L15.1 contact by antisense oligonucleotides or mutation reduced P RNA-alone and holoenzyme activity by one to two orders of magnitude in vitro, largely retarded gel mobility of the RNA and further affected the structure of regions P7/P8/P10.1, P15 and L15.2, and abolished the ability of B. subtilis P RNA to complement a P RNA-deficient Escherichia coli strain. We also provide mutational evidence that an L9-P1 tertiary contact, as found in some Mycoplasma type B RNAs, is not formed in canonical type B RNAs as represented by B. subtilis P RNA. We finally explored the P5.1 and P15 stem-loop structures as targets for LNA-modified antisense oligonucleotides. Oligonucleotides targeting P15, but not those directed against P5.1, were found to efficiently anneal to P RNA and to inhibit activity (IC50 of ∼2 nM) when incubated with preassembled B. subtilis RNase P holoenzymes.

  19. Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium†

    PubMed Central

    Figueroa, Jonine D.; Garcia-Closas, Montserrat; Humphreys, Manjeet; Platte, Radka; Hopper, John L.; Southey, Melissa C.; Apicella, Carmel; Hammet, Fleur; Schmidt, Marjanka K.; Broeks, Annegien; Tollenaar, Rob A.E.M.; Van't Veer, Laura J.; Fasching, Peter A.; Beckmann, Matthias W.; Ekici, Arif B.; Strick, Reiner; Peto, Julian; dos Santos Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael; Burwinkel, Barbara; Marme, Federik; Schneeweiss, Andreas; Sohn, Christof; Bojesen, Stig; Flyger, Henrik; Nordestgaard, Børge G.; Benítez, Javier; Milne, Roger L.; Ignacio Arias, Jose; Zamora, M. Pilar; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Rahman, Nazneen; Turnbull, Clare; Seal, Sheila; Renwick, Anthony; Brauch, Hiltrud; Justenhoven, Christina; Brüning, Thomas; Chang-Claude, Jenny; Hein, Rebecca; Wang-Gohrke, Shan; Dörk, Thilo; Schürmann, Peter; Bremer, Michael; Hillemanns, Peter; Nevanlinna, Heli; Heikkinen, Tuomas; Aittomäki, Kristiina; Blomqvist, Carl; Bogdanova, Natalia; Antonenkova, Natalia; Rogov, Yuri I.; Karstens, Johann Hinrich; Bermisheva, Marina; Prokofieva, Darya; Hanafievich Gantcev, Shamil; Khusnutdinova, Elza; Lindblom, Annika; Margolin, Sara; Chenevix-Trench, Georgia; Beesley, Jonathan; Chen, Xiaoqing; Mannermaa, Arto; Kosma, Veli-Matti; Soini, Ylermi; Kataja, Vesa; Lambrechts, Diether; Yesilyurt, Betül T.; Chrisiaens, Marie-Rose; Peeters, Stephanie; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Barile, Monica; Couch, Fergus; Lee, Adam M.; Diasio, Robert; Wang, Xianshu; Giles, Graham G.; Severi, Gianluca; Baglietto, Laura; Maclean, Catriona; Offit, Ken; Robson, Mark; Joseph, Vijai; Gaudet, Mia; John, Esther M.; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene; Knight, Julia A.; Marie Mulligan, Anna; O'Malley, Frances P.; Brinton, Louise A.; Sherman, Mark E.; Lissowska, Jolanta; Chanock, Stephen J.; Hooning, Maartje; Martens, John W.M.; van den Ouweland, Ans M.W.; Collée, J. Margriet; Hall, Per; Czene, Kamila; Cox, Angela; Brock, Ian W.; Reed, Malcolm W.R.; Cross, Simon S.; Pharoah, Paul; Dunning, Alison M.; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Shen, Chen-Yang; Ding, Shian-ling; Hsu, Huan-Ming; Yu, Jyh-Cherng; Anton-Culver, Hoda; Ziogas, Argyrios; Ashworth, Alan; Swerdlow, Anthony; Jones, Michael; Orr, Nick; Trentham-Dietz, Amy; Egan, Kathleen; Newcomb, Polly; Titus-Ernstoff, Linda; Easton, Doug; Spurdle, Amanda B.

    2011-01-01

    A genome-wide association study (GWAS) identified single-nucleotide polymorphisms (SNPs) at 1p11.2 and 14q24.1 (RAD51L1) as breast cancer susceptibility loci. The initial GWAS suggested stronger effects for both loci for estrogen receptor (ER)-positive tumors. Using data from the Breast Cancer Association Consortium (BCAC), we sought to determine whether risks differ by ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), grade, node status, tumor size, and ductal or lobular morphology. We genotyped rs11249433 at 1p.11.2, and two highly correlated SNPs rs999737 and rs10483813 (r2= 0.98) at 14q24.1 (RAD51L1), for up to 46 036 invasive breast cancer cases and 46 930 controls from 39 studies. Analyses by tumor characteristics focused on subjects reporting to be white women of European ancestry and were based on 25 458 cases, of which 87% had ER data. The SNP at 1p11.2 showed significantly stronger associations with ER-positive tumors [per-allele odds ratio (OR) for ER-positive tumors was 1.13, 95% CI = 1.10–1.16 and, for ER-negative tumors, OR was 1.03, 95% CI = 0.98–1.07, case-only P-heterogeneity = 7.6 × 10−5]. The association with ER-positive tumors was stronger for tumors of lower grade (case-only P= 6.7 × 10−3) and lobular histology (case-only P= 0.01). SNPs at 14q24.1 were associated with risk for most tumor subtypes evaluated, including triple-negative breast cancers, which has not been described previously. Our results underscore the need for large pooling efforts with tumor pathology data to help refine risk estimates for SNP associations with susceptibility to different subtypes of breast cancer. PMID:21852249

  20. ISS Update: NEEMO 16

    NASA Video Gallery

    ISS Update commentator Josh Byerly interviews astronaut Stan Love about the NEEMO 16 mission from Aquarius Base. Questions? Ask us on Twitter @NASA_Johnson and include the hashtag #askStation. For ...

  1. Update of the BIPM comparison BIPM.RI(II)-K1.Sr-85 of activity measurements of the radionuclide 85Sr to include the 2009 result of the POLATOM (Poland)

    NASA Astrophysics Data System (ADS)

    Michotte, C.; Ratel, G.; Courte, S.; Dziel, T.; Listkowska, A.

    2015-01-01

    Since 1975, ten laboratories have submitted 27 samples of known activity of 85Sr to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Sr-85. The values of the activity submitted were between about 0.2 MBq and 19 MBq. The key comparison reference value (KCRV) has been recalculated to include the primary standardization result for the POLATOM, Poland. There are now four results in the BIPM.RI(II)-K1.Sr-85 comparison. The degrees of equivalence between each equivalent activity measured in the SIR and the updated KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  2. Multiple Sclerosis: An Update.

    PubMed

    Faguy, Kathryn

    2016-05-01

    Multiple sclerosis (MS) is the most common disabling neurologic condition in young adults and imposes high financial and quality of life costs on patients, their families, and society. Yet, developments in the battle against MS include new treatments to slow its progression and updated diagnostic criteria that can accelerate diagnosis and effective treatment. This article offers a review and update on the disease, focusing on risk factors and possible causes, symptoms, forms of MS, diagnostic criteria and tools, and the expanding array of approved treatments. It also reports on the skyrocketing cost of MS drugs, misdiagnosis, and special patient populations with MS.

  3. SEI: An update

    NASA Technical Reports Server (NTRS)

    Peach, Lewis L., Jr.

    1991-01-01

    An update on the Space Exploration Initiative (SEI) is given in viewgraph form. Topics covered include the key prerequisites of human exploration, project planning, Mars and lunar explorations, supporting technologies, near-term strategies for SEI, human support elements, and Space Station Freedom SEI accommodations.

  4. Cultural practices updates

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cultural practice updates from 2013 included the effects of shredding in spring, residue management, periodic flooding, no-till fertilizer applications, and billet planting on cane tonnage and sugar yield. Shredding, whether high or low, had little impacts in 2013. However, burning following shreddi...

  5. COPPER RESEARCH UPDATE

    EPA Science Inventory

    This presentation provides an update and overview of new research results and remaining research needs with respect to copper corrosion control issues. The topics to be covered include: occurrence of elevated copper release in systems that meet the Action Level; impact of water c...

  6. Community Update, 1999.

    ERIC Educational Resources Information Center

    Anderson, Julie, Ed.

    1999-01-01

    This document consists of nine issues (covering January through December 1999) of the newsletter "Community Update," containing articles on community and family involvement in education. Article topics include: new programs to help students prepare for college early; Vice President Al Gore announced the first-ever national Hispanic Education…

  7. Updating Older Fume Hoods.

    ERIC Educational Resources Information Center

    Saunders, G. Thomas

    1985-01-01

    Provides information on updating older fume hoods. Areas addressed include: (1) adjustment of the hood's back baffle; (2) hood air leakage; (3) light level; (4) hood location in relation to room traffic and room air; and (5) establishing and maintaining hood performance. (JN)

  8. Community Update, 2001.

    ERIC Educational Resources Information Center

    Ashby, Nicole, Ed.

    2001-01-01

    This document consists of 10 issues (covering January through December 2000) of the newsletter, "Community Update," which features articles on community and family involvement in education. In addition to the articles, each issue (except the Special Issue) includes a preview of the month's Satellite Town Meeting; events and information…

  9. Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the 2010 result of the LNE-LNHB (France)

    NASA Astrophysics Data System (ADS)

    Michotte, C.; Ratel, G.; Courte, S.; Cassette, P.; Moune, M.

    2016-01-01

    Since 2001, six national metrology institutes (NMI) have submitted seven samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.F-18. The values of the activity submitted were between about 1 MBq and 18 MBq. The primary standardization result for the LNE-LNHB, France, replaces their earlier result of 2002 and the key comparison reference value (KCRV) has been recalculated. In the frame of the BIPM.RI(II)-K4.F18 comparison, the NPL updated their result in the KCDB. Consequently there are now five results in the BIPM.RI(II)-K1.F-18 comparison. The degrees of equivalence between each equivalent activity measured in the SIR and the updated KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  10. 75 FR 70124 - Product List Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... 30 CFR Part 3020 Product List Update AGENCY: Postal Regulatory Commission. ACTION: Final rule... Commission order. The referenced policy assumes periodic updates. The updates are identified in the body of this document. The product lists, which are re-published in their entirety, include these...

  11. 77 FR 75377 - Product List Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ... 39 CFR Part 3020 Product List Update AGENCY: Postal Regulatory Commission. ACTION: Final rule... Commission order. The referenced policy assumes periodic updates. The updates are identified in the body of this document. The product lists, which are re-published in their entirety, include these...

  12. 76 FR 1357 - Product List Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-10

    ... 30 CFR Part 3020 Product List Update AGENCY: Postal Regulatory Commission. ACTION: Final rule... Commission order. The referenced policy assumes periodic updates. The updates are identified in the body of this document. The product lists, which are re-published in their entirety, include these...

  13. ISS Update: Transit of Venus

    NASA Video Gallery

    ISS Update commentator Brandi Dean interviews Mario Runco, NASA astronaut, about Venus's transit across the sun on June 5, 2012. Questions? Ask us on Twitter @NASA_Johnson and include the hashtag #...

  14. The X-33 Program Update

    NASA Technical Reports Server (NTRS)

    Dill, Charlie

    2000-01-01

    This viewgraph presentation gives an overview of the X-33 program update, including details on program objectives and plans, the X-33 configuration, technologies used, and X-33 assembly and test status.

  15. RESRAD update

    SciTech Connect

    Yu, C.; Cheng, J.J.; Zielen, A.J.; Jones, L.G.; LePoire, D.J.; Wang, Y.Y. ); Yuan, Y.C. ); Loureiro, C.O. . Escola de Engenharia); Wallo, A. III; Peterson, H. . Offic

    1993-01-01

    A microcomputer program called RESRAD, which implements a pathway analysis method for radiological risk assessment, was developed by Argonne National Laboratory (ANL) in 1989. This program is used to derive allowable residual concentrations of radionuclides in soil and to predict effective dose equivalents and excess cancer incidence risks incurred by an individual exposed to radioactive materials. Since its development, the RESRAD code has been adopted by DOE in Order 5400.5 for the derivation of soil cleanup criteria and dose calculations, and it has been used widely by DOE, other agencies, and their contractors. The original models used by ANL to develop RESRAD were initially developed as part of a DOE effort that began in the early 1980s and involved most of the national laboratories and DOE program offices. The RESRAD code is continuously improved and updated to incorporate comments from users and new features that ease the interaction with users and increase the code's capability and flexibility. The DOE Offices of Environmental Guidance and Environmental Restoration also provide periodic guidance regarding any significant changes to the code. The RESRAD update, Version 5.0, has substantial improvements in many aspects compared with the last version released in 1989.

  16. RESRAD update

    SciTech Connect

    Yu, C.; Cheng, J.J.; Zielen, A.J.; Jones, L.G.; LePoire, D.J.; Wang, Y.Y.; Yuan, Y.C.; Loureiro, C.O.; Wallo, A. III; Peterson, H.; H Williams, W.A.

    1993-05-01

    A microcomputer program called RESRAD, which implements a pathway analysis method for radiological risk assessment, was developed by Argonne National Laboratory (ANL) in 1989. This program is used to derive allowable residual concentrations of radionuclides in soil and to predict effective dose equivalents and excess cancer incidence risks incurred by an individual exposed to radioactive materials. Since its development, the RESRAD code has been adopted by DOE in Order 5400.5 for the derivation of soil cleanup criteria and dose calculations, and it has been used widely by DOE, other agencies, and their contractors. The original models used by ANL to develop RESRAD were initially developed as part of a DOE effort that began in the early 1980s and involved most of the national laboratories and DOE program offices. The RESRAD code is continuously improved and updated to incorporate comments from users and new features that ease the interaction with users and increase the code`s capability and flexibility. The DOE Offices of Environmental Guidance and Environmental Restoration also provide periodic guidance regarding any significant changes to the code. The RESRAD update, Version 5.0, has substantial improvements in many aspects compared with the last version released in 1989.

  17. Working Memory Updating as a Predictor of Academic Attainment

    ERIC Educational Resources Information Center

    Lechuga, M. Teresa; Pelegrina, Santiago; Pelaez, Jose L.; Martin-Puga, M. Eva; Justicia, M. Jose

    2016-01-01

    There is growing evidence supporting the importance of executive functions, and specifically working memory updating (WMU), for children's academic achievement. This study aimed to assess the specific contribution of updating to the prediction of academic performance. Two updating tasks, which included different updating components, were…

  18. Document Update and Compare

    NASA Technical Reports Server (NTRS)

    Knoch, C. F.; Caldwell, D. C.; Caldwell, D. L.

    1983-01-01

    Document Update and Compare programs provide simple computerized documentmaintenance system on Data General NOVA 840 computer. Document Update program allows user to update document either by batch or terminal input. Documents are modified and lists of modifications printed out.

  19. Exploration Update

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Delores Beasley, NASA Public Affairs, introduces the panel who consist of: Scott "Doc" Horowitz, Associate Administrator of Exploration Systems from NASA Headquarters; Jeff Henley, Constellation Program Manager from NASA Johnson Space Flight Center; and Steve Cook, Manager Exploration Launch Office at NASA Marshall Space Flight Center. Scott Horowitz presents a short video entitled, "Ares Launching the Future". He further explains how NASA personnel came up with the name of Ares and where the name Ares was derived. Jeff Henley, updates the Constellation program and Steve Cook presents two slide presentations detailing the Ares l crew launch vehicle and Ares 5 cargo launch vehicle. A short question and answer period from the news media follows.

  20. SIM-Lite Update

    NASA Technical Reports Server (NTRS)

    Shao, Michael

    2008-01-01

    Discussion focus on: SIM-Lite Instrument Update - 6m baseline, 50cm, approximately 900M cost; Technology Update - Systematic errors and floor; SIM-Lite terrestrial planet discovery capability; Double blind multiple planet study summary; and the changing landscape of exoplanet science and the role of SIM-Lite. Slides include technology to flight component engineering; instrumental systematic errors; ultra deep search for Earth clones; double blind test, astrometric detection of Earths in multiplanet systems; the current era of exoplanet science and where SIM-Lite fits in; the next frontier and where SIM-Lite fits in, why SIM is unique in discovering Earths; imaging planet status is uncertain without masses and ages; SIM role in establishing how planetary systems form and evolve; and SIM probes of broad planet mass range around young stars.

  1. Sensors, Update 9

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    2001-10-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  2. Sensors, Update 2

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    1996-10-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Furthermore, the sensor market as well as peripheral aspects such as standards are covered. Each volume is divided into four sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  3. Sensors, Update 10

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Fedder, Gary K.; Korvink, Jan G.

    2002-04-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  4. Sensors, Update 1

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    1996-12-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Treatments include current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Furthermore, the sensor market as well as peripheral aspects such as standards are covered. Each volume is divided into four sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides an overview of suppliers and market trends for a particular section, and Sensor Standards, reviews recent legislation and requirements for sensors. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  5. Sensors, Update 12

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Fedder, Gary K.; Korvink, Jan G.

    2003-04-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  6. Sensors, Update 8

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    2001-02-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections: Sensor Technology reviews highlights in applied and basic research, while Sensor Applications covers new or improved applications of sensors, and Sensor Markets provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be invaluable to scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  7. Update on blepharospasm

    PubMed Central

    Hallett, Mark; Evinger, Craig; Jankovic, Joseph; Stacy, Mark

    2008-01-01

    This review updates understanding and research on blepharospasm, a subtype of focal dystonia. Topics covered include clinical aspects, pathology, pathophysiology, animal models, dry eye, photophobia, epidemiology, genetics, and treatment. Blepharospasm should be differentiated from apraxia of eyelid opening. New insights into pathology and pathophysiology are derived from different types of imaging, including magnetic resonance studies. Physiologic studies indicate increased plasticity and trigeminal sensitization. While botulinum neurotoxin injections are the mainstay of therapy, other therapies are on the horizon. GLOSSARY BFMDRS = Burke-Fahn-Marsden dystonia rating scale; BoNT = botulinum neurotoxin; DBS = deep brain stimulation; DTI = diffusion tensor imaging; FDG = 18fluorodeoxyglucose; VBM = voxel-based morphometry. PMID:18852443

  8. Energy Education Materials Bibliography - Update.

    ERIC Educational Resources Information Center

    Minnesota State Energy Agency, St. Paul.

    Presented is an updated version of a previous bibliography prepared by the Minnesota State Energy Agency. The materials included in this document are indexed according to grade level and according to whether they are background materials or classroom activities. Each of the items listed were evaluated and included into either the "A"…

  9. An update on potato crisps contents of moisture, fat, salt and fatty acids (including trans-fatty acids) with special emphasis on new oils/fats used for frying.

    PubMed

    Gonçalves Albuquerque, Tânia; Sanches-Silva, Ana; Santos, Lèlita; Costa, Helena S

    2012-09-01

    Eighteen brands of potato crisps, frequently consumed, were analyzed to establish their nutritional value in relation to salt, fat and fatty acid (FA) composition. The purpose of the present study was to determine moisture, total fat, salt contents and FA profiles (including trans-FAs), and to identify the oil/fat used for frying of the 18 brands of potato crisps. Our results show that salt content ranged from 0.127 to 2.77 g/100 g and total fat content of potato crisps varied between 20.0 and 42.8 g/100 g. With respect to FAs analysis, palmitic acid (C16:0), oleic acid (C18:1) and linoleic acid (C18:2) were the major FAs found in the analyzed potato crisps. It is clear from our work that nowadays most potato crisps are currently produced using oils with high contents in unsaturated FAs, which can be considered as healthier from a nutritional point of view. Nevertheless, some brands of potato crisps still use palm oil or a blend of palm oil and other fats/oils, which are very rich in saturated FAs.

  10. Update on equine allergies.

    PubMed

    Fadok, Valerie A

    2013-12-01

    Horses develop many skin and respiratory disorders that have been attributed to allergy. These disorders include pruritic skin diseases, recurrent urticaria, allergic rhinoconjunctivitis, and reactive airway disease. Allergen-specific IgE has been detected in these horses, and allergen-specific immunotherapy is used to ameliorate clinical signs. The best understood atopic disease in horses is insect hypersensitivity, but the goal of effective treatment with allergen-specific immunotherapy remains elusive. In this review, updates in pathogenesis of allergic states and a brief mention of the new data on what is known in humans and dogs and how that relates to equine allergic disorders are discussed.

  11. Rebuild America partner update, November--December 1998

    SciTech Connect

    1998-11-01

    This issue of the update includes articles on retrofitting Duke University facilities, energy efficiency updates to buildings in Portland, Oregon, Salisbury, North Carolina, Hawaii, Roanoke-Chowan, Virginia, and energy savings centered designs for lighting systems.

  12. Legislative Update, June 2010. Report 10-13

    ERIC Educational Resources Information Center

    Blair, Julia

    2010-01-01

    This update contains analyses of legislation being tracked by California Postsecondary Education Commission (CPEC) staff. It has updated positions on bills as adopted in the Commission meeting on June 8. A matrix of bills tracked by CPEC staff is included.

  13. Exhaust Trail of STS-51-L

    NASA Technical Reports Server (NTRS)

    1986-01-01

    On January 28, 1986, the Space Shuttle Challenger and her seven-member crew were lost when a ruptured O-ring in the right Solid Rocket Booster caused an explosion soon after launch. This photograph, taken a few seconds after the accident, shows the Space Shuttle Main Engines and Solid Rocket Booster exhaust plumes entwined around a ball of gas from the External Tank. Because shuttle launches had become almost routine after fifty successful missions, those watching the shuttle launch in person and on television found the sight of the explosion especially shocking and difficult to believe until NASA confirmed the accident.

  14. Part C Updates. 11th Edition

    ERIC Educational Resources Information Center

    Danaher, Joan; Goode, Sue; Lazara, Alex

    2010-01-01

    "Part C Updates" is a compilation of information on various aspects of the Early Intervention Program for Infants and Toddlers with Disabilities (Part C) of the Individuals with Disabilities Education Act (IDEA). This is the eleventh volume in a series of compilations, which included two editions of Part H Updates, the former name of the…

  15. Part C Updates. 10th Edition

    ERIC Educational Resources Information Center

    Goode, Sue; Lazara, Alex; Danaher, Joan

    2008-01-01

    "Part C Updates" is a compilation of information on various aspects of the Early Intervention Program for Infants and Toddlers with Disabilities (Part C) of the Individuals with Disabilities Education Act (IDEA). This is the tenth volume in a series of compilations, which included two editions of Part H Updates, the former name of the…

  16. Census in Schools Educator Update, February 2010

    ERIC Educational Resources Information Center

    US Census Bureau, 2010

    2010-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter includes the following items: (1) Have You Seen the Census…

  17. 75 FR 17641 - Updating Fire Safety Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    ... AFFAIRS 38 CFR Parts 17 and 59 RIN 2900-AN57 Updating Fire Safety Standards AGENCY: Department of Veterans..., including standards for fire safety and heating and cooling systems. The proposed amendments would help.... Comments should indicate that they are submitted in response to ``RIN 2900-AN57--Updating Fire...

  18. 76 FR 10246 - Updating Fire Safety Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... AFFAIRS 38 CFR Parts 17 and 59 RIN 2900-AN57 Updating Fire Safety Standards AGENCY: Department of Veterans... for VA approval of such facilities, including standards for fire safety and heating and cooling.... Comments should indicate that they are submitted in response to ``RIN 2900-AN57--Updating Fire...

  19. Biomass [updated

    SciTech Connect

    Turhollow Jr, Anthony F

    2016-01-01

    Biomass resources and conversion technologies are diverse. Substantial biomass resources exist including woody crops, herbaceous perennials and annuals, forest resources, agricultural residues, and algae. Conversion processes available include fermentation, gasification, pyrolysis, anaerobic digestion, combustion, and transesterification. Bioderived products include liquid fuels (e.g. ethanol, biodiesel, and gasoline and diesel substitutes), gases, electricity, biochemical, and wood pellets. At present the major sources of biomass-derived liquid fuels are from first generation biofuels; ethanol from maize and sugar cane (89 billion L in 2013) and biodiesel from vegetable oils and fats (24 billion liters in 2011). For other than traditional uses, policy in the forms of mandates, targets, subsidies, and greenhouse gas emission targets has largely been driving biomass utilization. Second generation biofuels have been slow to take off.

  20. Propane Update.

    ERIC Educational Resources Information Center

    Brantner, Max

    1984-01-01

    Reports on a northern Illinois school bus fleet converted to propane fuel in 1981 and 1982. Includes tables showing, first, total annual fuel costs before and after conversion and, second, fuel efficiency for 16 buses using propane and three using gasoline. Notes precautions for propane use. (MCG)

  1. Update Japan.

    ERIC Educational Resources Information Center

    Hoopes, Aaron

    This book is a guide intended for persons planning on relocating to Japan. Following a chapter on background information, 13 additional chapters lead the reader step-by-step through the relocation process. These chapters include: before leaving, on arrival, language, culture, doing business in Japan, household pointers and everyday life, schools…

  2. Updating Situation Models

    ERIC Educational Resources Information Center

    Zwaan, Rolf A.; Madden, Carol J.

    2004-01-01

    The authors examined how situation models are updated during text comprehension. If comprehenders keep track of the evolving situation, they should update their models such that the most current information, the here and now, is more available than outdated information. Contrary to this updating hypothesis, E. J. O'Brien, M. L. Rizzella, J. E.…

  3. Ebola Update.

    PubMed

    O'Keefe, Louise C

    2016-01-01

    The Ebola virus disease first appeared in 1976 in the Sudan and the Democratic Republic of Congo. The most recent outbreak occurred in West Africa in March 2014 and quickly spread in surrounding countries. Ebola spreads through direct contact with the body fluids of an infected individual. The incubation period for Ebola is 2 to 21 days. Individuals are infectious when symptomatic. Identifying individuals at high risk for Ebola in the United States includes early recognition of symptoms and a history of travel to an Ebola-affected area. Multiple diagnostic tests exist and should include a complete blood count and a comprehensive metabolic profile. Standard, contact, and droplet precautions are advised when taking care of patients with Ebola. Appropriate personal protective equipment as recommended by the Centers for Disease Control and Prevention should be worn. No vaccine or antiviral drug has been approved, but vaccine trials are under way. Occupational health nurses play a key role in educating employees about this disease.

  4. Updating the Behavior Engineering Model.

    ERIC Educational Resources Information Center

    Chevalier, Roger

    2003-01-01

    Considers Thomas Gilbert's Behavior Engineering Model as a tool for systematically identifying barriers to individual and organizational performance. Includes a detailed case study and a performance aid that incorporates gap analysis, cause analysis, and force field analysis to update the original model. (Author/LRW)

  5. Wind turbine reliability database update.

    SciTech Connect

    Peters, Valerie A.; Hill, Roger Ray; Stinebaugh, Jennifer A.; Veers, Paul S.

    2009-03-01

    This report documents the status of the Sandia National Laboratories' Wind Plant Reliability Database. Included in this report are updates on the form and contents of the Database, which stems from a fivestep process of data partnerships, data definition and transfer, data formatting and normalization, analysis, and reporting. Selected observations are also reported.

  6. Community Update, 1998-1999.

    ERIC Educational Resources Information Center

    Anderson, Julie, Ed.

    1999-01-01

    This document consists of ten issues of the newsletter "Community Update," containing articles on community and family involvement in education. Article topics include: a college education is necessary and possible; math and science study points out problems and positive solutions; the "America Reads Challenge"; meeting the…

  7. [Antidote update].

    PubMed

    Kiyota, Kazuya

    2016-02-01

    In Japan, several products of the antidote for poisoning have been authorized in clinical use from some recent years. For example, Hydroxcobalamin for cyanide poisoning was introduced in 2008. In 2009, Ministry of Health, Labour and Welfare invited suggestions of demand of pharmaceutical products which is high in the need in the medical care but yet unauthorized. Japanese Society for Clinical Toxicology and Japan Poison Information Center applied some candidates including methyleneblue (MB) and fomepizole, both of them were authorized in clinical market in 2015. MB is the medicine for methemoglobinemia, caused by variety of chemical products such as nitrogen oxide. Fomepizole is the antidote for methanol and ethyleneglycol, blocking alcohol dehydrogenase.

  8. Macrofouling control technology update

    SciTech Connect

    Tsou, J.L.; Armor, A.F.

    1996-12-31

    Macrofouling of condenser systems with debris, fish, clams, barnacles, mussels, algae, and other marine organisms can significantly affect power plant availability and performance. Typical difficulties include increased condenser back pressure due to reduced cooling-water flow, malfunctioning of on-line tube-cleaning equipment, and accelerated corrosion and erosion of tubing. In some severe cases, condenser back pressure increased to a point that the turbine had to be tripped. In 1981 EPRI initiated a research project to develop utility industry guidelines for reducing macrofouling problems. In 1987 EPRI published the Guidelines on Macrofouling Control Technology. Since then significant progress has been made by EPRI, utility members, equipment manufacturers, and others. The purpose of this paper is to update the macrofouling control technology. Control technology covered will include thermal treatment, mechanical removal devices, antifouling coatings, and chemical treatment.

  9. Update: nail unit dermatopathology.

    PubMed

    Stewart, Campbell L; Rubin, Adam I

    2012-01-01

    Nail unit dermatopathology is a growing field filled with many challenges. Many advances in this field have been made in the last 5 years. This review article provides an update on new information and studies published in that period of time. We divided these works into different sections, including clinical and pathologic challenges in diagnosis and treatment of nail disorders, nail unit biopsy and processing techniques, normal nail unit histology, nail plate structural and growth pathology, metabolic disease, inflammatory conditions, onychomycosis, benign growths, malignant growths, and dyschromias. Specific highlights include advances in the marking and orientation of nail unit biopsies for improved histologic interpretation, improved nail plate softening techniques, new methods for histologic evaluation of onychomycosis, descriptions of newly described benign growths unique to the nail unit, and the morphologic and immunohistochemical distinction between benign and malignant pigmented lesions of the nail unit.

  10. 49 CFR 360.5 - Updating user fees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... REGISTRATION AND INSURANCE § 360.5 Updating user fees. (a) Update. Each fee established in this part may be... the current percentage factor to updated direct labor, including current governmental overhead costs... office general and administrative costs will be accomplished by applying the current percentage factor...

  11. 29 CFR 1904.33 - Retention and updating.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Requirements § 1904.33 Retention and updating. (a) Basic requirement. You must save the OSHA 300 Log, the... to update the OSHA 300 Log during the five-year storage period? Yes, during the storage period, you must update your stored OSHA 300 Logs to include newly discovered recordable injuries or illnesses...

  12. 29 CFR 1904.33 - Retention and updating.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Requirements § 1904.33 Retention and updating. (a) Basic requirement. You must save the OSHA 300 Log, the... to update the OSHA 300 Log during the five-year storage period? Yes, during the storage period, you must update your stored OSHA 300 Logs to include newly discovered recordable injuries or illnesses...

  13. Melasma update

    PubMed Central

    Sarkar, Rashmi; Arora, Pooja; Garg, Vijay Kumar; Sonthalia, Sidharth; Gokhale, Narendra

    2014-01-01

    Melasma is an acquired pigmentary disorder characterized by symmetrical hyperpigmented macules on the face. Its pathogenesis is complex and involves the interplay of various factors such as genetic predisposition, ultraviolet radiation, hormonal factors, and drugs. An insight into the pathogenesis is important to devise treatment modalities that accurately target the disease process and prevent relapses. Hydroquinone remains the gold standard of treatment though many newer drugs, especially plant extracts, have been developed in the last few years. In this article, we review the pathogenetic factors involved in melasma. We also describe the newer treatment options available and their efficacy. We carried out a PubMed search using the following terms “melasma, pathogenesis, etiology, diagnosis, treatment” and have included data of the last few years. PMID:25396123

  14. Drilling update

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    At its March 31 meeting the governing board of the Joint Oceanographic Institutions, Inc. (JOI), designated Texas A&M University to direct scientific operations for the new phase of scientific ocean drilling. William Merrell, associate dean of geosciences at Texas A&M, is leading an interim planning team in implementing the recommendations of the National Science Foundation's (NSF) Ad Hoc Advisory Group on Crustal Studies (Eos, February 22, 1983, p. 73). The ad hoc group, chaired by Charles Drake, recommended that scientific ocean drilling be pursued not with the Glomar Challenger or the Glomar Explorer, but with one of the roughly half-dozen commercial drilling ships that have become available with the slackening of the commercial drilling market.Foremost of the tasks facing the interim planning team is to write a request for proposals (RFP) for a drill ship and to define performance criteria for a commercial drilling platform. The RFP is expected to be issued by Texas A&M in 6-8 weeks, according to Philip Rabinowitz, acting project director and a professor in the university's oceanography department. Once those tasks are completed and a successful bidder is found, a formal proposal will be made to NSF through JOI. The proposal will be subject to the usual NSF peer review process. If the proposal is approved, Rabinowitz said that Texas A&M would expect actual drilling to begin in October 1984. In addition to Merrell and Rabinowitz, the interim planning team also includes acting chief scientist Stefan Gartner.

  15. Neurofibromatosis update.

    PubMed

    Crawford, Alvin H; Schorry, Elizabeth K

    2006-01-01

    Type 1 neurofibromatosis (NF-1), also known as von Recklinghausen disease, is one of the most common human single-gene disorders, affecting at least 1 million persons throughout the world. It encompasses a spectrum of multifacted disorders and may present with a wide range of clinical manifestations, including abnormalities of the skin, nervous tissue, bones, and soft tissues. The condition can be conclusively diagnosed when 2 of 7 criteria established by the National Institutes of Health Consensus Development Conference are met. Most children with NF-1 have no major orthopedic problems. For those with musculoskeletal involvement, the most important issue is early recognition. Spinal deformity, congenital tibial dysplasia (congenital bowing and pseudarthrosis), and disorders of excessive bone and soft-tissue growth are the three types of musculoskeletal manifestitations that require evaluation. Statistics gathered from the Cincinnati Children's Hospital Neurofibromatosis Center database of 588 patients show the incidence of spinal deformity in children with NF-1 to be 21%; pectus deformity, 4.3%; limb-length inequality, 7.1%; congenital tibial dysplasia, 5%; hemihypertrophy, 1.4%; and plexiform neurofibromas, 25%. The orthopedic complications can be managed, but only rarely are they cured. Current developments in molecular genetics are exciting and give hope to more positive outcomes.

  16. ISS Update: High Rate Communications System

    NASA Video Gallery

    ISS Update Commentator Pat Ryan interviews Diego Serna, Communications and Tracking Officer, about the High Rate Communications System. Questions? Ask us on Twitter @NASA_Johnson and include the ha...

  17. GEMS: A Study Group to Update Dietitians.

    ERIC Educational Resources Information Center

    Gobberdiel, Linda

    1983-01-01

    Discusses study group technique to update dietitians. Includes objectives (such as providing opportunities for sharing of information among area hospitals' dietetic departments and creating greater exposure to nutritional care philosophies/methods), subgroup responsibilities, and journals used. (JN)

  18. DOE Wind Program Update: June 4, 2006;

    SciTech Connect

    Not Available

    2006-06-01

    The DOE Wind Program Update provides WindPower Conference attendees with information about recent DOE events, including Assistant Secretary Karsner, a wind turbine blade test facility CRADA, and 2005 Wind Energy Award recipients.

  19. ILRS Website Update

    NASA Technical Reports Server (NTRS)

    Noll, Carey E.; Torrence, Mark H.; Pollack, Nathan H.; Tyahla, Lori J.

    2013-01-01

    The ILRS website, http://ilrs.gsfc.nasa.gov, is the central source of information for all aspects of the service. The website provides information on the organization and operation of the ILRS and descriptions of ILRS components data, and products. Furthermore, the website provides an entry point to the archive of these data products available through the data centers. Links are provided to extensive information on the ILRS network stations including performance assesments and data quality evaluations. Descriptions of suported satellite missions (current, future, and past) are provided to aid in station acquisition and data analysis. The website was reently redesigned. Content was reviewed during the update process, ensuring information is current and useful. This poster will provide specific examples of key sections, applicaitons, and webpages.

  20. Perinatal neuroprotection update

    PubMed Central

    Jelin, Angie C.; Salmeen, Kirsten; Gano, Dawn; Burd, Irina; Thiet, Mari-Paule

    2016-01-01

    Antepartum, intrapartum, and neonatal events can result in a spectrum of long-term neurological sequelae, including cerebral palsy, cognitive delay, schizophrenia, and autism spectrum disorders [1]. Advances in obstetrical and neonatal care have led to survival at earlier gestational ages and consequently increasing numbers of periviable infants who are at significant risk for long-term neurological deficits. Therefore, efforts to decrease and prevent cerebral insults attempt not only to decrease preterm delivery but also to improve neurological outcomes in infants delivered preterm. We recently published a comprehensive review addressing the impacts of magnesium sulfate, therapeutic hypothermia, delayed cord clamping, infections, and prevention of preterm delivery on the modification of neurological risk [2]. In this review, we will briefly provide updates to the aforementioned topics as well as an expansion on avoidance of toxin and infections, specifically the Zika virus. PMID:27606053

  1. Update in urethral stents.

    PubMed

    Bahouth, Z; Meyer, G; Yildiz, G; Nativ, O; Moskovitz, B

    2016-10-01

    Urethral stents were first introduced in 1988, and since then, they have undergone significant improvements. However, they did not gain a wide popularity and their use is limited to a small number of centers around the world. Urethral stents can be used in the entire urethra and for various and diverse indications. In the anterior urethra, it can be used to treat urethral strictures. In the prostatic urethra, they can be used for the treatment of prostatic obstruction, including benign, malignant and iatrogenic prostatic obstruction. Moreover, although not widely used, it can be also applied for the treatment of posterior urethral stricture and bladder neck contracture, usually resulting in urinary incontinence and the need for subsequent procedures. Our main experience are with Allium urethral stents, and as such, we provide the latest updates in urethral stents with special emphasis on the various types of Allium urethral stents: bulbar, prostatic and bladder neck stents.

  2. ISS Update: Suitport

    NASA Video Gallery

    ISS Update commentator Lynnette Madison interviews Mallory Jennings, Suitport Human Testing Lead, about making spacewalks easier and more efficient with the Suitport. Questions? Ask us on Twitter @...

  3. Update in Internal Medicine

    PubMed Central

    López-Jiménez, Francisco; Brito, Máximo; Aude, Y. Wady; Scheinberg, Phillip; Kaplan, Mariana; Dixon, Denise A.; Schneiderman, Neil; Trejo, Jorge F.; López-Salazar, Luis Humberto; Ramírez-Barba, Ector Jaime; Kalil, Roberto; Ortiz, Carmen; Goyos, José; Buenaño, Alvaro; Kottiech, Samer; Lamas, Gervasio A.

    2009-01-01

    More than 500,000 new medical articles are published every year and available time to keep updated is scarcer every day. Nowadays, the task of selecting useful, consistent, and relevant information for clinicians is a priority in many major medical journals. This review has the aim of gathering the results of the most important findings in clinical medicine in the last few years. It is focused on results from randomized clinical trials and well-designed observational research. Findings were included preferentially if they showed solid results, and we avoided as much as possible including only preliminary data, or results that included only non-clinical outcomes. Some of the most relevant findings reported here include the significant benefit of statins in patients with coronary artery disease even with mean cholesterol level. It also provides a substantial review of the most significant trials assessing the effectiveness of IIb/IIIa receptor blockers. In gastroenterology many advances have been made in the H. pylori eradication, and the finding that the cure of H. pylori infection may be followed by gastroesophageal reflux disease. Some new antivirals have shown encouraging results in patients with chronic hepatitis. In the infectious disease arena, the late breaking trials in anti-retroviral disease are discussed, as well as the new trends regarding antibiotic resistance. This review approaches also the role of leukotriene modifiers in the treatment of asthma and discusses the benefit of using methylprednisolone in patients with adult respiratory distress syndrome, among many other advances in internal medicine. PMID:11068074

  4. Clinical update: hepatitis B.

    PubMed

    Tran, Tram T

    2007-07-01

    Chronic hepatitis B (CHB) remains a global health problem, with disproportionately high prevalence rates approaching 10-15% in the Asian population worldwide and in Asian immigrants in the United States. Chronic infection complications, including cirrhosis and hepatocellular carcinoma, occur in 1 5-40% of infected individuals, and important recent data from the REVEAL study have suggested that, independent of other factors, high viral replication may impact long-term disease outcomes. More recent recognition of parameters for defining normal transaminases may also affect decision-making for therapy initiation. Recently, new treatment options have been effective at viral suppression, with lower rates of viral resistance compared to lamivudine. Currently, therapies for hepatitis B treatment include interferon, lamivudine, adefovir, entecavir, and telbivudine. Treatment considerations need to take into account therapy duration and risks, specifically the development of viral resistance. Recently updated guidelines and algorithms use viral replication, alanine aminotransferase levels, and severity of histologic disease as the determining factors for treatment. Therapy length is dependent on hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive CHB patients. In patients with the precore/basal core promoter HBeAg-negative CHB, the treatment goal is continued viral suppression. Future options, including new oral agents, therapeutic vaccines, and combination therapies, require further study.

  5. Update on Internet2 Activities

    NASA Astrophysics Data System (ADS)

    Yun, T. Charles

    [14 Feb 2003] I propose an overview talk/update on several Internet2 activities that might be of interest to the e-VLBI community including: End-to-End performance project (PiPES); national (American) fiber infrastructure (a.k.a. National Light Rail, FiberCo, etc.); request for interest in short-term, dedicated, test-labmdas (inside the US only at this point).

  6. Environmental Regulatory Update Table, October 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  7. Environmental Regulatory Update Table, November 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-12-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  8. Environmental regulatory update table, July 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-08-01

    This Environmental Regulatory Update Table (July 1991) provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  9. Environmental Regulatory Update Table, August 1991

    SciTech Connect

    Houlberg, L.M., Hawkins, G.T.; Salk, M.S.

    1991-09-01

    This Environmental Regulatory Update Table (August 1991) provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  10. Environmental Regulatory Update Table, September 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-10-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  11. Environmental Regulatory Update Table, January 1991

    SciTech Connect

    Hawkins, G.T.; Houlberg, L.M.; Salk, M.S.

    1991-02-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  12. Environmental Regulatory Update Table, October 1990

    SciTech Connect

    Houlberg, L.M.; Noghrei-Nikbakht, P.A.; Salk, M.S.

    1990-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  13. Environmental Regulatory Update Table, December 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1992-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  14. Environmental regulatory update table, March 1989

    SciTech Connect

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-04-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  15. Environmental Regulatory Update Table, August 1990

    SciTech Connect

    Houlberg, L.M.; Nikbakht, A.; Salk, M.S.

    1990-09-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  16. Environmental Regulatory Update Table, September 1990

    SciTech Connect

    Houlberg, L.M.; Nikbakht, A.; Salk, M.S.

    1990-10-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  17. Environmental Regulatory Update Table, December 1989

    SciTech Connect

    Houlbert, L.M.; Langston, M.E. ); Nikbakht, A.; Salk, M.S. )

    1990-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  18. Environmental Regulatory Update Table, April 1989

    SciTech Connect

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  19. Reporting Items for Updated Clinical Guidelines: Checklist for the Reporting of Updated Guidelines (CheckUp)

    PubMed Central

    Vernooij, Robin W. M.; Alonso-Coello, Pablo; Brouwers, Melissa

    2017-01-01

    Background Scientific knowledge is in constant development. Consequently, regular review to assure the trustworthiness of clinical guidelines is required. However, there is still a lack of preferred reporting items of the updating process in updated clinical guidelines. The present article describes the development process of the Checklist for the Reporting of Updated Guidelines (CheckUp). Methods and Findings We developed an initial list of items based on an overview of research evidence on clinical guideline updating, the Appraisal of Guidelines for Research and Evaluation (AGREE) II Instrument, and the advice of the CheckUp panel (n = 33 professionals). A multistep process was used to refine this list, including an assessment of ten existing updated clinical guidelines, interviews with key informants (response rate: 54.2%; 13/24), a three-round Delphi consensus survey with the CheckUp panel (33 participants), and an external review with clinical guideline methodologists (response rate: 90%; 53/59) and users (response rate: 55.6%; 10/18). CheckUp includes 16 items that address (1) the presentation of an updated guideline, (2) editorial independence, and (3) the methodology of the updating process. In this article, we present the methodology to develop CheckUp and include as a supplementary file an explanation and elaboration document. Conclusions CheckUp can be used to evaluate the completeness of reporting in updated guidelines and as a tool to inform guideline developers about reporting requirements. Editors may request its completion from guideline authors when submitting updated guidelines for publication. Adherence to CheckUp will likely enhance the comprehensiveness and transparency of clinical guideline updating for the benefit of patients and the public, health care professionals, and other relevant stakeholders. PMID:28072838

  20. a Bottom-Up Geosptial Data Update Mechanism for Spatial Data Infrastructure Updating

    NASA Astrophysics Data System (ADS)

    Tian, W.; Zhu, X.; Liu, Y.

    2012-08-01

    Currently, the top-down spatial data update mechanism has made a big progress and it is wildly applied in many SDI (spatial data infrastructure). However, this mechanism still has some issues. For example, the update schedule is limited by the professional department's project, usually which is too long for the end-user; the data form collection to public cost too much time and energy for professional department; the details of geospatial information does not provide sufficient attribute, etc. Thus, how to deal with the problems has become the effective shortcut. Emerging Internet technology, 3S technique and geographic information knowledge which is popular in the public promote the booming development of geoscience in volunteered geospatial information. Volunteered geospatial information is the current "hotspot", which attracts many researchers to study its data quality and credibility, accuracy, sustainability, social benefit, application and so on. In addition to this, a few scholars also pay attention to the value of VGI to support the SDI updating. And on that basis, this paper presents a bottom-up update mechanism form VGI to SDI, which includes the processes of match homonymous elements between VGI and SDI vector data , change data detection, SDI spatial database update and new data product publication to end-users. Then, the proposed updating cycle is deeply discussed about the feasibility of which can detect the changed elements in time and shorten the update period, provide more accurate geometry and attribute data for spatial data infrastructure and support update propagation.

  1. Veterinary medicines update.

    PubMed

    2017-03-11

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues.

  2. Veterinary medicines: product update.

    PubMed

    2014-04-05

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues.

  3. Veterinary medicines: product update.

    PubMed

    2014-03-01

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues.

  4. Veterinary medicines: product update.

    PubMed

    2014-08-02

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues.

  5. Veterinary medicines: product update.

    PubMed

    2014-11-01

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues.

  6. Veterinary medicines: product update.

    PubMed

    2014-09-06

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK, and on other relevant issues.

  7. Red Hill Updates

    EPA Pesticide Factsheets

    This and other periodic updates are intended to keep the public informed on major progress being made to protect public health and the environment at the Red Hill Underground Fuel Storage Facility in Hawaii.

  8. ISS Update: Suitport Testing

    NASA Video Gallery

    ISS Update commentator Lynnette Madison interviews Joel Maganza, Test Director, about thermal vacuum chambers and unmanned and human-testing with the Suitport. Questions? Ask us on Twitter @NASA_Jo...

  9. Update on Banned Substances 2013

    PubMed Central

    Barnes, Kenneth P.; Rainbow, Catherine R.

    2013-01-01

    Context: Doping has been pervasive throughout the history of athletic competitions and has only recently been regulated by organizations such as the World Anti-Doping Agency (WADA), US Anti-Doping Agency (USADA), and the National Collegiate Athletic Association (NCAA). These regulatory bodies were created to preserve fair play and maintain the safety of the participants. Their updated 2013 lists of banned substances and practices include a variety of drugs and practices that could cause harm to an athlete or give one an unfair competitive advantage. Evidence Acquisition: Published websites for the WADA, USADA, and NCAA were investigated. These governing bodies update and publish their lists annually. Results: The WADA, USADA, and NCAA monitor anabolic steroids, hormones, growth factors, β-agonists, hormone and metabolic modulators, masking agents, street drugs, manipulation of blood and blood components, chemical and physical manipulation, gene doping, stimulants, narcotics, glucocorticosteroids, and β-blockers. Some substances may be used by athletes but require formal exemption. The WADA has also recently created a category of nonapproved substances that have yet to be identified to curb athletes from experimenting with new doping agents. Conclusion: The lists of banned substances and practices per the WADA, USADA, and NCAA are in place to ensure the integrity of sports and maintain safe competition. Health care providers who work with athletes under the jurisdiction of these organizations should review updated lists of banned substances when prescribing medications. PMID:24427415

  10. Update in adrenocortical carcinoma.

    PubMed

    Fassnacht, Martin; Kroiss, Matthias; Allolio, Bruno

    2013-12-01

    Adrenocortical carcinoma (ACC) is an orphan malignancy that has attracted increasing attention during the last decade. Here we provide an update on advances in the field since our last review published in this journal in 2006. The Wnt/β-catenin pathway and IGF-2 signaling have been confirmed as frequently altered signaling pathways in ACC, but recent data suggest that they are probably not sufficient for malignant transformation. Thus, major players in the pathogenesis are still unknown. For diagnostic workup, comprehensive hormonal assessment and detailed imaging are required because in most ACCs, evidence for autonomous steroid secretion can be found and computed tomography or magnetic resonance imaging (if necessary, combined with functional imaging) can differentiate benign from malignant adrenocortical tumors. Surgery is potentially curative in localized tumors. Thus, we recommend a complete resection including lymphadenectomy by an expert surgeon. The pathology report should demonstrate the adrenocortical origin of the lesion (eg, by steroidogenic factor 1 staining) and provide Weiss score, resection status, and quantitation of the proliferation marker Ki67 to guide further treatment. Even after complete surgery, recurrence is frequent and adjuvant mitotane treatment improves outcome, but uncertainty exists as to whether all patients benefit from this therapy. In advanced ACC, mitotane is still the standard of care. Based on the FIRM-ACT trial, mitotane plus etoposide, doxorubicin, and cisplatin is now the established first-line cytotoxic therapy. However, most patients will experience progress and require salvage therapies. Thus, new treatment concepts are urgently needed. The ongoing international efforts including comprehensive "-omic approaches" and next-generation sequencing will improve our understanding of the pathogenesis and hopefully lead to better therapies.

  11. An update on chemistry analyzers.

    PubMed

    Vap, L M; Mitzner, B

    1996-09-01

    This update of six chemistry analyzers available to the clinician discusses several points that should be considered prior to the purchase of equipment. General topics include how to best match an instrument to clinic needs and the indirect costs associated with instrument operation. Quality assurance recommendations are discussed and common terms are defined. Specific instrument features, principles of operation, performance, and costs are presented. The information provided offers potential purchasers an objective approach to the evaluation of a chemistry analyzer for the veterinary clinic.

  12. Update of Thyroid Developmental Genes.

    PubMed

    Stoupa, Athanasia; Kariyawasam, Dulanjalee; Carré, Aurore; Polak, Michel

    2016-06-01

    Thyroid dysgenesis (TD) is the most common cause of congenital hypothyroidism in iodine-sufficient regions and includes a spectrum of developmental anomalies. The genetic components of TD are complex. Although a sporadic disease, advances in developmental biology have revealed monogenetic forms of TD. Inheritance is not based on a simple Mendelian pattern and additional genetic elements might contribute to the phenotypic spectrum. This article summarizes the key steps of normal thyroid development and provides an update on responsible genes and underlying mechanisms of TD. Up-to-date technologies in genetics and biology will allow us to advance in our knowledge of TD.

  13. Macrophage Cryptococcus interactions: an update

    PubMed Central

    Mansour, Michael K.; Reedy, Jennifer L.; Tam, Jenny M.; Vyas, Jatin M.

    2014-01-01

    Cryptococcus species are fungal pathogens that are a leading cause of mortality. Initial inoculation is through the pulmonary route and, if disseminated, results in severe invasive infection including meningoencephalitis. Macrophages are the dominant phagocytic cell that interacts with Cryptococcus. Emerging theories suggest that Cryptococcus microevolution in macrophages is linked to survival and virulence within the host. In addition, Cryptococcus elaborates virulence factors as well as usurps host machinery to establish macrophage activation states that are permissive to intracellular survival and replication. In this review, we provide an update of the recent findings pertaining to macrophage interaction with Cryptococcus and focus on new avenues for biomedical research. PMID:24660045

  14. The Scout Launcher - An update

    NASA Astrophysics Data System (ADS)

    Wilson, A.

    1981-05-01

    An update is given for the Scout launches since April 1978. Scout is a four-stage solid-propellant launcher with its motors divided by transition sections carrying electronics and attitude motors, topped by a payload and its shroud. The payloads have carried a wide range of experiments, including Explorer atmospheric, Navy navigation satellites, and all of Britain's Ariels. Since launch 98 in April 1978, Scout has been employed three times more in 1979, and when the program is phased out in 1985, well over 110 Scouts will have been launched. This last phase from launch 102 onward, will involve exclusively military missions.

  15. Q2/Q3 2016 Solar Industry Update

    SciTech Connect

    Feldman, David; Boff, Daniel; Margolis, Robert

    2016-10-11

    This technical presentation provides an update on the major trends that occurred in the solar industry in the Q2 and Q3 of 2016. Major topics of focus include global and U.S. supply and demand, module and system price, investment trends and business models, and updates on U.S. government programs supporting the solar industry.

  16. Q3/Q4 2016 Solar Industry Update

    SciTech Connect

    Feldman, David; Boff, Daniel; Margolis, Robert

    2016-12-21

    This technical presentation provides an update on the major trends that occurred in the solar industry in the Q3 and Q4 of 2016. Major topics of focus include global and U.S. supply and demand, module and system price, investment trends and business models, and updates on U.S. government programs supporting the solar industry.

  17. Census in Schools Educator Update, July/August 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter includes the following items: (1) Census in Schools and…

  18. 10 CFR 603.885 - Updated program plans and budgets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Updated program plans and budgets. 603.885 Section 603.885... program plans and budgets. In addition to reports on progress to date, a TIA may include a provision requiring the recipient to annually prepare an updated technical plan for future conduct of the...

  19. 10 CFR 72.248 - Safety analysis report updating.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Safety analysis report updating. 72.248 Section 72.248... Approval of Spent Fuel Storage Casks § 72.248 Safety analysis report updating. (a) Each certificate holder... section, the final safety analysis report (FSAR) to assure that the information included in the...

  20. Environmental Regulatory Update Table, January/February 1995

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Mayer, S.J.; Salk, M.S.

    1995-03-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives impacting environmental, health, and safety management responsibilities. the table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  1. VIIP 2017 Clinical Update

    NASA Technical Reports Server (NTRS)

    Tarver, William

    2017-01-01

    INTRODUCTION: NASA's Space Medicine community knowledge regarding the "Vision Impairment Intracranial Pressure", or VIIP.has been evolving over time.. Various measures of occupational health related to this condition had to be determined and then plans/processes put into place. The most robust of these processes were inititated in 2010. This presentation will provide a clinic update of the astronaut occupational health data related to VIIP. METHODS: NASA and its international partners require its astronauts to undergo routine health measures deemed important to monitoring VIIP. The concern is that the spaceflight environment aboard ISS could cause some astronauts to have physiologic changes detrimental to either ongoing mission operations or long-term health related to the ocular system and possibly the CNS. Specific medical tests include but are not limited to brain/orbit MRI (NASA unique protocol), OCT, fundoscopy and ocular ultrasound. Measures are taken prior to spaceflight, in-flight and post-flight. Measures to be reported include incidence of disc edema, globe flattening, choroidal folds, ONSD and change in refractive error. RESULTS: 73 ISS astronauts have been evaluated at least partially for VIIP related measures. Of these individuals, approximately 1 in 7 have experienced disc edema. The prevalence of the other findings is more complicated as the medical testing has changed over time. Overall, 26 separate individuals have experienced at least one of the findings NASA has associated with VIIP Another confounding factor is most of the astronauts have prior spaceflight experience at the time of the "pre-flight" testing. DISCUSSION: In 2010 NASA and its US operating segment (USOS) partners (CSA, ESA and JAXA) began routine occupational monitoring and data collection for most VIIP related changes. Interpretation of that data is extremely challenging for several reasons. For example, the determination of disc edema is the most complete finding as we have had

  2. Accountability Update, March 2000.

    ERIC Educational Resources Information Center

    Washington State Higher Education Coordinating Board, Olympia.

    This report provides the Washington State legislature, the Governor, and other interested parties with an update on the accountability performance of each of the state's public baccalaureate institutions (Central Washington University, Eastern Washington University, Evergreen State College, Washington State University, Western Washington…

  3. Year 2000 Update.

    ERIC Educational Resources Information Center

    Berg, Frances M.

    1994-01-01

    Presents an update on the Year 2000 objectives for the nation that establish targets in 22 priority areas. The article offers information from a study on exercise by the President's Council on Physical Fitness and Sports, reviews Healthy People 2000 data, and lists Year 2000 physical activity and fitness objectives. (SM)

  4. Southern Horticultural Lab Update

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This publication is a new quarterly update for members of the Mississippi Nursery and Landscape Association that is published quarterly in their association newsletter. Two other versions of this newsletter are being submitted to the Louisiana Nursery and Landscape Association (LALNLA) and the Alaba...

  5. Updating: Learning versus Supposing

    ERIC Educational Resources Information Center

    Zhao, Jiaying; Crupi, Vincenzo; Tentori, Katya; Fitelson, Branden; Osherson, Daniel

    2012-01-01

    Bayesian orthodoxy posits a tight relationship between conditional probability and updating. Namely, the probability of an event "A" after learning "B" should equal the conditional probability of "A" given "B" prior to learning "B". We examine whether ordinary judgment conforms to the orthodox view. In three experiments we found substantial…

  6. Special Education Law Update.

    ERIC Educational Resources Information Center

    Zirkel, Perry A.

    1989-01-01

    Due to an error made in printing Professor Zirkel's "Special Education Law; Recent Developments" in Volume 48 (October 13, 1988), these updates to the article are printed. Citations are organized under the following major sections: (1) diagnosis and placement; (2) treatment issues; (3) financial issues; and (4) gifted students. (MLF)

  7. Supreme Court Update

    ERIC Educational Resources Information Center

    Taylor, Kelley R.

    2009-01-01

    "Chief Justice Flubs Oath." "Justice Ginsburg Has Cancer Surgery." At the start of this year, those were the news headlines about the U.S. Supreme Court. But January 2009 also brought news about key education cases--one resolved and two others on the docket--of which school administrators should take particular note. The Supreme Court updates on…

  8. Updates to Selected Analytical Methods for Environmental Remediation and Recovery (SAM)

    EPA Pesticide Factsheets

    View information on the latest updates to methods included in EPA's Selected Analytical Methods for Environmental Remediation and Recovery (SAM), including the newest recommended methods and publications.

  9. Updates to the MSFC Meteoroid Stream Model

    NASA Astrophysics Data System (ADS)

    Moser, Danielle E.; Cooke, William J.

    2008-06-01

    The Marshall Space Flight Center (MSFC) Meteoroid Stream Model simulates particle ejection and subsequent evolution from comets in order to provide meteor shower forecasts to spacecraft operators for hazard mitigation and planning purposes. The model, previously detailed in Moser and Cooke (Earth Moon Planets 95, 141 (2004)), has recently been updated; the changes include the implementation of the RADAU integrator, an improved planetary treatment, and the inclusion of general relativistic effects in the force function. The results of these updates are investigated with respect to various meteoroid streams and the outcome presented.

  10. Apollo Lunar Sample Photograph Digitization Project Update

    NASA Technical Reports Server (NTRS)

    Todd, N. S.; Lofgren, G. E.

    2012-01-01

    This is an update of the progress of a 4-year data restoration project effort funded by the LASER program to digitize photographs of the Apollo lunar rock samples and create high resolution digital images and undertaken by the Astromaterials Acquisition and Curation Office at JSC [1]. The project is currently in its last year of funding. We also provide an update on the derived products that make use of the digitized photos including the Lunar Sample Catalog and Photo Database[2], Apollo Sample data files for GoogleMoon[3].

  11. State energy-price system: 1981 update

    SciTech Connect

    Fang, J.M.; Imhoff, K.L.; Hood, L.J.

    1983-08-01

    This report updates the State Energy Price Data System (STEPS) to include state-level energy prices by fuel and by end-use sectors for 1981. Both physical unit prices and Btu prices are presented. Basic documentation of the data base remains generally the same as in the original report: State Energy Price System; Volume 1: Overview and Technical Documentation (DOE/NBB-0029 Volume 1 of 2, November 1982). The present report documents only the changes in procedures necessitated by the update to 1981 and the corrections to the basic documentation.

  12. Energy 101: Wind Turbines - 2014 Update

    SciTech Connect

    2014-05-06

    See how wind turbines generate clean electricity from the power of wind. The video highlights the basic principles at work in wind turbines, and illustrates how the various components work to capture and convert wind energy to electricity. This updated version also includes information on the Energy Department's efforts to advance offshore wind power. Offshore wind energy footage courtesy of Vestas.

  13. Energy 101: Wind Turbines - 2014 Update

    ScienceCinema

    None

    2016-07-12

    See how wind turbines generate clean electricity from the power of wind. The video highlights the basic principles at work in wind turbines, and illustrates how the various components work to capture and convert wind energy to electricity. This updated version also includes information on the Energy Department's efforts to advance offshore wind power. Offshore wind energy footage courtesy of Vestas.

  14. Assessment Update: The First Ten Years.

    ERIC Educational Resources Information Center

    National Center for Higher Education Management Systems, Boulder, CO.

    This document provides complete collections of columns from the journal "Assessment Update" for the past 10 years. By-lined columns from Trudy W. Banta, Editor, include articles on: (1) encouraging faculty involvement in assessment; (2) the growing variety of assessment methods; (3) assessment in response to external pressures: performance funding…

  15. Internet Basics: Update 1996. ERIC Digest.

    ERIC Educational Resources Information Center

    Tennant, Roy

    This update to a previous digest briefly describes the Internet computer network, the physical connections and communication protocols that make it possible, and the applications and information resources the network provides. The applications covered include electronic mail and listservs, the world wide web, telnet connections with remote library…

  16. [Updates and interpretations of 2017 NCCN guidelines for bone cancer].

    PubMed

    Niu, X H

    2017-01-01

    The NCCN guidelines for bone cancer are generally updated 1-2 times one year, the contents include diagnosis, treatment guidelines and the latest developments. The latest version of 2017 guideline of bone cancer is released recently. It includes multidisciplinary treatment of common primary bone cancer including diagnosis, surgery, drugs and radiotherapy. It covers osteosarcoma, chondrosarcoma, Ewing's sarcoma, giant cell tumor of bone and chordoma. In this article, the core contents and the updates are illustrated.

  17. Sepsis: An update in management.

    PubMed

    Galen, Benjamin T; Sankey, Christopher

    2015-11-01

    Hospitalists are a critical link in providing evidence-based care for patients with sepsis across the disease spectrum, from early recognition to recovery. The past decade of sepsis research has led to significant findings that will change clinical practice for hospital medicine practitioners. Although the incidence of severe sepsis in the United States has continued to rise, in-hospital mortality has declined. Management of the spectrum of sepsis disorders is no longer restricted to the intensive care unit (ICU). This review article will provide an update in the management of sepsis for hospitalists based on recently published pivotal studies. The expanding evidence base in sepsis includes early goal-directed therapy/clinical endpoints/sepsis bundles, antibiotics and source control, volume resuscitation, ICU considerations (including the use of insulin and corticosteroids), mortality/complications, and the newly recognized condition of "sepsis survivorship".

  18. Updated emissions from ocean shipping

    NASA Astrophysics Data System (ADS)

    Corbett, James J.; Koehler, Horst W.

    2003-10-01

    Marine vessel inventories demonstrate that ship emissions cannot be neglected in assessing environmental impacts of air pollution, although significant uncertainty in these inventories remains. We address this uncertainty by employing a bottom-up estimate of fuel consumption and vessel activity for internationally registered fleets, including cargo vessels, other commercial vessels, and military vessels. We identify model bias in previous work, which assumed internationally registered ships primarily consume international marine fuels. Updated results suggest fuel consumption is ˜289 million metric tons per year, more than twice the quantity reported as international fuel. According to our analysis, fuel used by internationally registered fleets is apparently allocated to both international and domestic fuel statistics; this implies either that ships operate along domestic routes much of the time or that marine fuel sales to these ships may be misassigned. If the former is true, then allocation of emissions to international shipping routes may underestimate near-coastal emissions from ships. Our updated inventories increases previous ship emissions inventories for all pollutants; for example, global NOx emissions (˜6.87 Tg N) are more than doubled. This work also produces detailed sensitivity analyses of inputs to these estimates, identifying uncertainty in vessel duty-cycle as critical to overall emissions estimates. We discuss implications for assessing ship emissions impacts.

  19. Perforated peptic ulcer - an update

    PubMed Central

    Chung, Kin Tong; Shelat, Vishalkumar G

    2017-01-01

    Peptic ulcer disease (PUD) affects 4 million people worldwide annually. The incidence of PUD has been estimated at around 1.5% to 3%. Perforated peptic ulcer (PPU) is a serious complication of PUD and patients with PPU often present with acute abdomen that carries high risk for morbidity and mortality. The lifetime prevalence of perforation in patients with PUD is about 5%. PPU carries a mortality ranging from 1.3% to 20%. Thirty-day mortality rate reaching 20% and 90-d mortality rate of up to 30% have been reported. In this review we have summarized the current evidence on PPU to update readers. This literature review includes the most updated information such as common causes, clinical features, diagnostic methods, non-operative and operative management, post-operative complications and different scoring systems of PPU. With the advancement of medical technology, PUD can now be treated with medications instead of elective surgery. The classic triad of sudden onset of abdominal pain, tachycardia and abdominal rigidity is the hallmark of PPU. Erect chest radiograph may miss 15% of cases with air under the diaphragm in patients with bowel perforation. Early diagnosis, prompt resuscitation and urgent surgical intervention are essential to improve outcomes. Exploratory laparotomy and omental patch repair remains the gold standard. Laparoscopic surgery should be considered when expertise is available. Gastrectomy is recommended in patients with large or malignant ulcer. PMID:28138363

  20. NXE pellicle: development update

    NASA Astrophysics Data System (ADS)

    Brouns, Derk; Bendiksen, Aage; Broman, Par; Casimiri, Eric; Colsters, Paul; de Graaf, Dennis; Harrold, Hilary; Hennus, Piet; Janssen, Paul; Kramer, Ronald; Kruizinga, Matthias; Kuntzel, Henk; Lafarre, Raymond; Mancuso, Andrea; Ockwell, David; Smith, Daniel; van de Weg, David; Wiley, Jim

    2016-09-01

    ASML introduced the NXE pellicle concept, a removable pellicle solution that is compatible with current and future patterned mask inspection methods. We will present results of how we have taken the idea from concept to a demonstrated solution enabling the use of EUV pellicle by the industry for high volume manufacturing. We will update on the development of the next generation of pellicle films with higher power capability. Further, we will provide an update on top level requirements for pellicles and external interface requirements needed to support NXE pellicle adoption at a mask shop. Finally, we will present ASML's pellicle handling equipment to enable pellicle use at mask shops and our NXE pellicle roadmap outlining future improvements.

  1. Sequence History Update Tool

    NASA Technical Reports Server (NTRS)

    Khanampompan, Teerapat; Gladden, Roy; Fisher, Forest; DelGuercio, Chris

    2008-01-01

    The Sequence History Update Tool performs Web-based sequence statistics archiving for Mars Reconnaissance Orbiter (MRO). Using a single UNIX command, the software takes advantage of sequencing conventions to automatically extract the needed statistics from multiple files. This information is then used to populate a PHP database, which is then seamlessly formatted into a dynamic Web page. This tool replaces a previous tedious and error-prone process of manually editing HTML code to construct a Web-based table. Because the tool manages all of the statistics gathering and file delivery to and from multiple data sources spread across multiple servers, there is also a considerable time and effort savings. With the use of The Sequence History Update Tool what previously took minutes is now done in less than 30 seconds, and now provides a more accurate archival record of the sequence commanding for MRO.

  2. Endodontic diagnostic terminology update.

    PubMed

    McClannahan, Scott B; Baisden, Michael K; Bowles, Walter R

    2011-01-01

    Determination of the etiology of the patient's chief complaint and a correct diagnosis are paramount prior to a recommendation of endodontic therapy. Reproduction of the patient's chief complaint is critical. If the chief complaint cannot be reproduced, consider consultation with or referral to an endodontist or orofacial pain specialist. The diagnostic terminology presented in this update provides for a more accurate description and communication of the health or pathological conditions of both pulpal and apical tissues. This information is summarized in Table I.

  3. How Documentalists Update SIMBAD

    NASA Astrophysics Data System (ADS)

    Buga, M.; Bot, C.; Brouty, M.; Bruneau, C.; Brunet, C.; Cambresy, L.; Eisele, A.; Genova, F.; Lesteven, S.; Loup, C.; Neuville, M.; Oberto, A.; Ochsenbein, F.; Perret, E.; Siebert, A.; Son, E.; Vannier, P.; Vollmer, B.; Vonflie, P.; Wenger, M.; Woelfel, F.

    2015-04-01

    The Strasbourg astronomical Data Center (CDS) was created in 1972 and has had a major role in astronomy for more than forty years. CDS develops a service called SIMBAD that provides basic data, cross-identifications, bibliography, and measurements for astronomical objects outside the solar system. It brings to the scientific community an added value to content which is updated daily by a team of documentalists working together in close collaboration with astronomers and IT specialists. We explain how the CDS staff updates SIMBAD with object citations in the main astronomical journals, as well as with astronomical data and measurements. We also explain how the identification is made between the objects found in the literature and those already existing in SIMBAD. We show the steps followed by the documentalist team to update the database using different tools developed at CDS, like the sky visualizer Aladin, and the large catalogues and survey database VizieR. As a direct result of this teamwork, SIMBAD integrates almost 10.000 bibliographic references per year. The service receives more than 400.000 queries per day.

  4. To Your Health: NLM Update transcript - Superbug in space

    MedlinePlus

    ... transcript031317.html To Your Health: NLM Update Transcript Superbug in space : 03/13/2017 To use the ... was memorable, its cargo includes an antibiotic-resistant superbug to be studied on the International Space Station ( ...

  5. National Solar Radiation Database 1991-2010 Update: User's Manual

    SciTech Connect

    Wilcox, S. M.

    2012-08-01

    This user's manual provides information on the updated 1991-2010 National Solar Radiation Database. Included are data format descriptions, data sources, production processes, and information about data uncertainty.

  6. EPA National Center for Computational Toxicology UPDATE (ICCVAM public forum)

    EPA Science Inventory

    A presentation to the ICCVAM Public Forum on several new and exciting activities at NCCT, including Chemical library update, Chemistry Dashboard, Retrofitting in vitro assays with metabolic competence and In vitro PK.

  7. Updates in diabetic peripheral neuropathy.

    PubMed

    Juster-Switlyk, Kelsey; Smith, A Gordon

    2016-01-01

    Diabetes has become one of the largest global health-care problems of the 21 (st) century. According to the Centers for Disease Control and Prevention, the population prevalence of diabetes in the US is approaching 10% and is increasing by 5% each year. Diabetic neuropathy is the most common complication associated with diabetes mellitus. Diabetes causes a broad spectrum of neuropathic complications, including acute and chronic forms affecting each level of the peripheral nerve, from the root to the distal axon. This review will focus on the most common form, distal symmetric diabetic polyneuropathy. There has been an evolution in our understanding of the pathophysiology and the management of diabetic polyneuropathy over the past decade. We highlight these new perspectives and provide updates from the past decade of research.

  8. Updates in diabetic peripheral neuropathy

    PubMed Central

    Juster-Switlyk, Kelsey; Smith, A. Gordon

    2016-01-01

    Diabetes has become one of the largest global health-care problems of the 21 st century. According to the Centers for Disease Control and Prevention, the population prevalence of diabetes in the US is approaching 10% and is increasing by 5% each year. Diabetic neuropathy is the most common complication associated with diabetes mellitus. Diabetes causes a broad spectrum of neuropathic complications, including acute and chronic forms affecting each level of the peripheral nerve, from the root to the distal axon. This review will focus on the most common form, distal symmetric diabetic polyneuropathy. There has been an evolution in our understanding of the pathophysiology and the management of diabetic polyneuropathy over the past decade. We highlight these new perspectives and provide updates from the past decade of research. PMID:27158461

  9. The UCSC Genome Browser database: 2016 update

    PubMed Central

    Speir, Matthew L.; Zweig, Ann S.; Rosenbloom, Kate R.; Raney, Brian J.; Paten, Benedict; Nejad, Parisa; Lee, Brian T.; Learned, Katrina; Karolchik, Donna; Hinrichs, Angie S.; Heitner, Steve; Harte, Rachel A.; Haeussler, Maximilian; Guruvadoo, Luvina; Fujita, Pauline A.; Eisenhart, Christopher; Diekhans, Mark; Clawson, Hiram; Casper, Jonathan; Barber, Galt P.; Haussler, David; Kuhn, Robert M.; Kent, W. James

    2016-01-01

    For the past 15 years, the UCSC Genome Browser (http://genome.ucsc.edu/) has served the international research community by offering an integrated platform for viewing and analyzing information from a large database of genome assemblies and their associated annotations. The UCSC Genome Browser has been under continuous development since its inception with new data sets and software features added frequently. Some release highlights of this year include new and updated genome browsers for various assemblies, including bonobo and zebrafish; new gene annotation sets; improvements to track and assembly hub support; and a new interactive tool, the “Data Integrator”, for intersecting data from multiple tracks. We have greatly expanded the data sets available on the most recent human assembly, hg38/GRCh38, to include updated gene prediction sets from GENCODE, more phenotype- and disease-associated variants from ClinVar and ClinGen, more genomic regulatory data, and a new multiple genome alignment. PMID:26590259

  10. The UCSC Genome Browser database: 2016 update.

    PubMed

    Speir, Matthew L; Zweig, Ann S; Rosenbloom, Kate R; Raney, Brian J; Paten, Benedict; Nejad, Parisa; Lee, Brian T; Learned, Katrina; Karolchik, Donna; Hinrichs, Angie S; Heitner, Steve; Harte, Rachel A; Haeussler, Maximilian; Guruvadoo, Luvina; Fujita, Pauline A; Eisenhart, Christopher; Diekhans, Mark; Clawson, Hiram; Casper, Jonathan; Barber, Galt P; Haussler, David; Kuhn, Robert M; Kent, W James

    2016-01-04

    For the past 15 years, the UCSC Genome Browser (http://genome.ucsc.edu/) has served the international research community by offering an integrated platform for viewing and analyzing information from a large database of genome assemblies and their associated annotations. The UCSC Genome Browser has been under continuous development since its inception with new data sets and software features added frequently. Some release highlights of this year include new and updated genome browsers for various assemblies, including bonobo and zebrafish; new gene annotation sets; improvements to track and assembly hub support; and a new interactive tool, the "Data Integrator", for intersecting data from multiple tracks. We have greatly expanded the data sets available on the most recent human assembly, hg38/GRCh38, to include updated gene prediction sets from GENCODE, more phenotype- and disease-associated variants from ClinVar and ClinGen, more genomic regulatory data, and a new multiple genome alignment.

  11. The Navy Precision Optical Interferometer: an update

    NASA Astrophysics Data System (ADS)

    Armstrong, J. T.; Baines, Ellyn K.; Schmitt, Henrique R.; Restaino, Sergio R.; Clark, James H.; Benson, James A.; Hutter, Donald J.; Zavala, Robert T.; van Belle, Gerard T.

    2016-08-01

    We describe the current status of the Navy Precision Optical Interferometer (NPOI), including developments since the last SPIE meeting. The NPOI group has added stations as far as 250m from the array center and added numerous infrastructure improvements. Science programs include stellar diameters and limb darkening, binary orbits, Be star disks, exoplanet host stars, and progress toward high-resolution stellar surface imaging. Technical and infrastructure projects include on-sky demonstrations of baseline bootstrapping with six array elements and of the VISION beam combiner, control system updates, integration of the long delay lines, and updated firmware for the Classic beam combiner. Our plans to add up to four 1.8 m telescopes are no longer viable, but we have recently acquired separate funding for adding three 1 m AO-equipped telescopes and an infrared beam combiner to the array.

  12. Fuel Cell Handbook update

    SciTech Connect

    Owens, W.R.; Hirschenhofer, J.H.; Engleman, R.R. Jr.; Stauffer, D.B.

    1993-11-01

    The objective of this work was to update the 1988 version of DOE`s Fuel Cell Handbook. Significant developments in the various fuel cell technologies required revisions to reflect state-of-the-art configurations and performance. The theoretical presentation was refined in order to make the handbook more useful to both the casual reader and fuel cell or systems analyst. In order to further emphasize the practical application of fuel cell technologies, the system integration information was expanded. In addition, practical elements, such as suggestions and guidelines to approximate fuel cell performance, were provided.

  13. Updating: learning versus supposing.

    PubMed

    Zhao, Jiaying; Crupi, Vincenzo; Tentori, Katya; Fitelson, Branden; Osherson, Daniel

    2012-09-01

    Bayesian orthodoxy posits a tight relationship between conditional probability and updating. Namely, the probability of an event A after learning B should equal the conditional probability of A given B prior to learning B. We examine whether ordinary judgment conforms to the orthodox view. In three experiments we found substantial differences between the conditional probability of an event A supposing an event B compared to the probability of A after having learned B. Specifically, supposing B appears to have less impact on the credibility of A than learning that B is true.

  14. Pump apparatus including deconsolidator

    DOEpatents

    Sonwane, Chandrashekhar; Saunders, Timothy; Fitzsimmons, Mark Andrew

    2014-10-07

    A pump apparatus includes a particulate pump that defines a passage that extends from an inlet to an outlet. A duct is in flow communication with the outlet. The duct includes a deconsolidator configured to fragment particle agglomerates received from the passage.

  15. Optical modulator including grapene

    DOEpatents

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  16. Update of the BIPM comparison BIPM.RI(II)-K1.Co-60 of activity measurements of the radionuclide 60Co to include the 2011 result of the CNEA (Argentina), the 2012 results of the BARC (India) and the NRC (Canada), and the 2014 result of the NIM (China)

    NASA Astrophysics Data System (ADS)

    Michotte, C.; Ratel, G.; Courte, S.; Arenillas, P.; Balpardo, C.; Joseph, L.; Anuradha, R.; Kulkarni, D. B.; Galea, R.; Moore, K.; Stroak, A.; Zhang, Ming; Liang, Juncheng; Liu, Haoran

    2017-01-01

    Since 2010, four national metrology institutes (NMI) have each submitted a sample of known activity of 60Co to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Co-60. The values of the activity submitted were between about 175 kBq and 1600 kBq. The primary standardization results for the CNEA, Argentina and the BARC, India replace their earlier result of 2003 and 2001, respectively. There are now seventeen results in the BIPM.RI(II)-K1.Co-60 comparison. The key comparison reference value (KCRV) has been updated using the power-moderated weighted mean. The degrees of equivalence between each equivalent activity measured in the SIR and the KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  17. The sensitivity method in finite element model updating: A tutorial

    NASA Astrophysics Data System (ADS)

    Mottershead, John E.; Link, Michael; Friswell, Michael I.

    2011-10-01

    The sensitivity method is probably the most successful of the many approaches to the problem of updating finite element models of engineering structures based on vibration test data. It has been applied successfully to large-scale industrial problems and proprietary codes are available based on the techniques explained in simple terms in this article. A basic introduction to the most important procedures of computational model updating is provided, including tutorial examples to reinforce the reader's understanding and a large scale model updating example of a helicopter airframe.

  18. Working Memory Updating Latency Reflects the Cost of Switching between Maintenance and Updating Modes of Operation

    ERIC Educational Resources Information Center

    Kessler, Yoav; Oberauer, Klaus

    2014-01-01

    Updating and maintenance of information are 2 conflicting demands on working memory (WM). We examined the time required to update WM (updating latency) as a function of the sequence of updated and not-updated items within a list. Participants held a list of items in WM and updated a variable subset of them in each trial. Four experiments that vary…

  19. Memory Updating and Mental Arithmetic

    PubMed Central

    Han, Cheng-Ching; Yang, Tsung-Han; Lin, Chia-Yuan; Yen, Nai-Shing

    2016-01-01

    Is domain-general memory updating ability predictive of calculation skills or are such skills better predicted by the capacity for updating specifically numerical information? Here, we used multidigit mental multiplication (MMM) as a measure for calculating skill as this operation requires the accurate maintenance and updating of information in addition to skills needed for arithmetic more generally. In Experiment 1, we found that only individual differences with regard to a task updating numerical information following addition (MUcalc) could predict the performance of MMM, perhaps owing to common elements between the task and MMM. In Experiment 2, new updating tasks were designed to clarify this: a spatial updating task with no numbers, a numerical task with no calculation, and a word task. The results showed that both MUcalc and the spatial task were able to predict the performance of MMM but only with the more difficult problems, while other updating tasks did not predict performance. It is concluded that relevant processes involved in updating the contents of working memory support mental arithmetic in adults. PMID:26869971

  20. Updates Technologies of Media Change

    ERIC Educational Resources Information Center

    Comer, Joshua

    2015-01-01

    Whether as status notifications in news feeds or interactive prompts in online video services, updates punctuate the background routines of media by bringing a variety of changes to the attention of users. In this dissertation I argue that updates rationalize media change by making previously obscure actions of users and movements of technologies…

  1. Effect of display update interval, update type, and background on perception of aircraft separation on a cockpit display on traffic information

    NASA Technical Reports Server (NTRS)

    Jago, S.; Baty, D.; Oconnor, S.; Palmer, E.

    1981-01-01

    The concept of a cockpit display of traffic information (CDTI) includes the integration of air traffic, navigation, and other pertinent information in a single electronic display in the cockpit. Concise display symbology was developed for use in later full-mission simulator evaluations of the CDTI concept. Experimental variables used included the update interval motion of the aircraft, the update type, (that is, whether the two aircraft were updated at the same update interval or not), the background (grid pattern or no background), and encounter type (straight or curved). Only the type of encounter affected performance.

  2. Toxoplasmosis – An update

    PubMed Central

    Mittal, Veena; Ichhpujani, R L

    2011-01-01

    Toxplasmosis is an important zoonotic disease caused by protozoan parasite Toxoplasma gondii. The disease affects one-third of the total world population. Transmission of the disease is mainly by ingestion of food or water contaminated with oocysts. Congenital toxoplasmosis occurs from the transplacental passage of the parasite from mother to fetus. In most adults it does not cause serious illness, but it can cause blindness and mental retardation in congenitally infected children, and it is a devastating disease in immunocompromised individuals. Diagnosis of toxoplasmosis can be established by the direct detection of the parasite or by serological methods. The most commonly used and effective therapeutic regimen is the combination of pyrimethamine with sulfadiazine and folinic acid. This article provides an overview and update on transmission, diagnosis, management, and prevention of toxoplasmosis. PMID:23508064

  3. Including Jews in Multiculturalism.

    ERIC Educational Resources Information Center

    Langman, Peter F.

    1995-01-01

    Discusses reasons for the lack of attention to Jews as an ethnic minority within multiculturalism both by Jews and non-Jews; why Jews and Jewish issues need to be included; and addresses some of the issues involved in the ethical treatment of Jewish clients. (Author)

  4. ADAS Update and Maintainability

    NASA Technical Reports Server (NTRS)

    Watson, Leela R.

    2010-01-01

    Since 2000, both the National Weather Service Melbourne (NWS MLB) and the Spaceflight Meteorology Group (SMG) have used a local data integration system (LOIS) as part of their forecast and warning operations. The original LOIS was developed by the Applied Meteorology Unit (AMU) in 1998 (Manobianco and Case 1998) and has undergone subsequent improvements. Each has benefited from three-dimensional (3-D) analyses that are delivered to forecasters every 15 minutes across the peninsula of Florida. The intent is to generate products that enhance short-range weather forecasts issued in support of NWS MLB and SMG operational requirements within East Central Florida. The current LDIS uses the Advanced Regional Prediction System (ARPS) Data Analysis System (AD AS) package as its core, which integrates a wide variety of national, regional, and local observational data sets. It assimilates all available real-time data within its domain and is run at a finer spatial and temporal resolution than current national or regional-scale analysis packages. As such, it provides local forecasters with a more comprehensive understanding of evolving fine-scale weather features. Over the years, the LDIS has become problematic to maintain since it depends on AMU-developed shell scripts that were written for an earlier version of the ADAS software. The goals of this task were to update the NWS MLB/SMG LDIS with the latest version of ADAS, incorporate new sources of observational data, and upgrade and modify the AMU-developed shell scripts written to govern the system. In addition, the previously developed ADAS graphical user interface (GUI) was updated. Operationally, these upgrades will result in more accurate depictions of the current local environment to help with short-range weather forecasting applications, while also offering an improved initialization for local versions of the Weather Research and Forecasting (WRF) model used by both groups.

  5. Environmental Regulatory Update Table, September/October 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operation and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  6. Environmental Regulatory Update Table, May/June 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-07-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bimonthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  7. Environmental Regulatory Update Table, March/April 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1992-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  8. Environmental Regulatory Update Table, March/April 1993. Revision 1

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bimonthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  9. Environmental Regulatory Update Table, March/April 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bimonthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  10. Environmental Regulatory Update Table July/August 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-09-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  11. Environmental Regulatory Update Table, January/February 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1992-03-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action. This table is for January/February 1992.

  12. Environmental Regulatory Update Table, November--December 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Lewis, E.B.; Salk, M.S.

    1993-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly wit information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  13. Environmental Regulatory Update Table, July--August 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Lewis, E.B.; Salk, M.S.

    1992-09-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  14. Environmental regulatory update table, September--October 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Lewis, E.B.; Salk, M.S.

    1992-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  15. Environmental Regulatory Update Table, January--February 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-03-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  16. Environmental regulatory update table, March--April 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Salk, M.S.

    1994-03-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  17. Environmental Regulatory Update Table, January--February 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1994-03-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations ad contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  18. Environmental Regulatory Update Table, November--December 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1994-01-01

    The Environmental Regulatory Update Table provides information on regulatory of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  19. Environmental regulatory update table: September/October 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Salk, M.S.

    1994-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  20. Environmental regulatory update table November--December 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Mayer, S.J.; Salk, M.S.

    1995-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  1. Environmental regulatory update table, July/August 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Salk, M.S.

    1994-09-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  2. Environmental sciences division: Environmental regulatory update table July 1988

    SciTech Connect

    Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1988-08-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  3. Environmental Regulatory Update Table, May--June 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Salk, M.S.

    1994-07-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bimonthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  4. OLTARIS - Overview and Recent Updates

    NASA Technical Reports Server (NTRS)

    Sandridge, C. A.

    2015-01-01

    The On-Line Tool for the Assessment of Radiation in Space (OLTARIS) is a web-based set of tools and models that allow engineers and scientists to assess the effects of space radiation in spacecraft, habitats, rovers, and spacesuits. The site is intended to be a design tool for those studying the effects of space radiation for current and future missions as well as a research tool for those developing advanced material and shielding concepts. The tools and models are built around the HZETRN radiation transport code and are currently focused on human-related responses. OLTARIS was deployed in 2008. Since that time, many improvements and additional capabilities have been added to the site. The purpose of this poster/presentation is to give an overview of the current capabilities of OLTARIS and focus on the updates to the site since the last workshop presentation in 2014. OLTARIS currently has 240 active accounts - 87 accounts are government (including NASA, ORNL, JPL, AFRL, and FAA), 76 are university professors/researchers/students, and 51 are industry (including Boeing, Space X, Lockheed-Martin, ATK, Northrup Grumman, and Bigelow Aerospace). There have been 14,000 jobs run through OLTARIS since counting began in November 2009. ITAR restrictions were recently reversed, so the site is now available to registered users worldwide.

  5. ISS Update: SpaceX Dragon Launch Update

    NASA Video Gallery

    NASA Public Affairs Office commentator Pat Ryan talks with Mike Horkachuck, NASA Project Executive for SpaceX, for an update on the SpaceX Dragon's next launch attempt scheduled for Tuesday at 3:44...

  6. Nutritional therapies (including fosteum).

    PubMed

    Nieves, Jeri W

    2009-03-01

    Nutrition is important in promoting bone health and in managing an individual with low bone mass or osteoporosis. In adult women and men, known losses of bone mass and microarchitecture occur, and nutrition can help minimize these losses. In every patient, a healthy diet with adequate protein, fruits, vegetables, calcium, and vitamin D is required to maintain bone health. Recent reports on nutritional remedies for osteoporosis have highlighted the importance of calcium in youth and continued importance in conjunction with vitamin D as the population ages. It is likely that a calcium intake of 1200 mg/d is ideal, and there are some concerns about excessive calcium intakes. However, vitamin D intake needs to be increased in most populations. The ability of soy products, particularly genistein aglycone, to provide skeletal benefit has been recently studied, including some data that support a new medical food marketed as Fosteum (Primus Pharmaceuticals, Scottsdale, AZ).

  7. Updated Kinematic Constraints on a Dark Disk

    NASA Astrophysics Data System (ADS)

    Kramer, Eric David; Randall, Lisa

    2016-06-01

    We update the method of the Holmberg & Flynn study, including an updated model of the Milky Way’s interstellar gas, radial velocities, an updated reddening map, and a careful statistical analysis, to bound the allowed surface density and scale height of a dark disk. We pay careful attention to the self-consistency of the model, including the gravitational influence of the dark disk on other disk components, and to the net velocity of the tracer stars. We find that the data set exhibits a non-zero bulk velocity in the vertical direction as well as a displacement from the expected location at the Galactic midplane. If not properly accounted for, these features would bias the bound toward low dark disk mass. We therefore perform our analysis two ways. In the first, using the traditional method, we subtract the mean velocity and displacement from the tracers’ phase space distributions. In the second method, we perform a non-equilibrium version of the HF method to derive a bound on the dark disk parameters for an oscillating tracer distribution. Despite updates in the mass model and reddening map, the traditional method results remain consistent with those of HF2000. The second, non-equilibrium technique, however, allows a surface density as large as 14 {M}⊙ {{{pc}}}-2 (and as small as 0 {M}⊙ {{{pc}}}-2), demonstrating much weaker constraints. For both techniques, the bound on surface density is weaker for larger scale height. In future analyses of Gaia data it will be important to verify whether the tracer populations are in equilibrium.

  8. Updates to the Demographic and Spatial Allocation Models to ...

    EPA Pesticide Factsheets

    EPA's announced the availability of the final report, Updates to the Demographic and Spatial Allocation Models to Produce Integrated Climate and Land Use Scenarios (ICLUS) (Version 2). This update furthered land change modeling by providing nationwide housing development scenarios up to 2100. This newest version includes updated population and land use data sets and addresses limitations identified in ICLUS v1 in both the migration and spatial allocation models. The companion user guide (Final Report) describes the development of ICLUS v2 and the updates that were made to the original data sets and the demographic and spatial allocation models. The GIS tool enables users to run SERGoM with the population projections developed for the ICLUS project and allows users to modify the spatial allocation housing density across the landscape.

  9. Updates to the Demographic and Spatial Allocation Models to ...

    EPA Pesticide Factsheets

    EPA announced the availability of the draft report, Updates to the Demographic and Spatial Allocation Models to Produce Integrated Climate and Land Use Scenarios (ICLUS) for a 30-day public comment period. The ICLUS version 2 (v2) modeling tool furthered land change modeling by providing nationwide housing development scenarios up to 2100. ICLUS V2 includes updated population and land use data sets and addressing limitations identified in ICLUS v1 in both the migration and spatial allocation models. The companion user guide describes the development of ICLUS v2 and the updates that were made to the original data sets and the demographic and spatial allocation models. [2017 UPDATE] Get the latest version of ICLUS and stay up-to-date by signing up to the ICLUS mailing list. The GIS tool enables users to run SERGoM with the population projections developed for the ICLUS project and allows users to modify the spatial allocation housing density across the landscape.

  10. Updating Risk Prediction Tools: A Case Study in Prostate Cancer

    PubMed Central

    Ankerst, Donna P.; Koniarski, Tim; Liang, Yuanyuan; Leach, Robin J.; Feng, Ziding; Sanda, Martin G.; Partin, Alan W.; Chan, Daniel W; Kagan, Jacob; Sokoll, Lori; Wei, John T; Thompson, Ian M.

    2013-01-01

    Online risk prediction tools for common cancers are now easily accessible and widely used by patients and doctors for informed decision-making concerning screening and diagnosis. A practical problem is as cancer research moves forward and new biomarkers and risk factors are discovered, there is a need to update the risk algorithms to include them. Typically the new markers and risk factors cannot be retrospectively measured on the same study participants used to develop the original prediction tool, necessitating the merging of a separate study of different participants, which may be much smaller in sample size and of a different design. Validation of the updated tool on a third independent data set is warranted before the updated tool can go online. This article reports on the application of Bayes rule for updating risk prediction tools to include a set of biomarkers measured in an external study to the original study used to develop the risk prediction tool. The procedure is illustrated in the context of updating the online Prostate Cancer Prevention Trial Risk Calculator to incorporate the new markers %freePSA and [−2]proPSA measured on an external case control study performed in Texas, U.S.. Recent state-of-the art methods in validation of risk prediction tools and evaluation of the improvement of updated to original tools are implemented using an external validation set provided by the U.S. Early Detection Research Network. PMID:22095849

  11. Tetraplegia Management Update.

    PubMed

    Fridén, Jan; Gohritz, Andreas

    2015-12-01

    Tetraplegia is a profound impairment of mobility manifesting as a paralysis of all 4 extremities owing to cervical spinal cord injury. The purpose of this article is to provide an update and analyze current management, treatment options, and outcomes of surgical reconstruction of arm and hand function. Surgical restoration of elbow and wrist extension or handgrip has tremendous potential to improve autonomy, mobility, and critical abilities, for example, eating, personal care, and self-catheterization and productive work in at least 70% of tetraplegic patients. Tendon and nerve transfers, tenodeses, and joint stabilizations reliably enable improved arm and hand usability, reduce muscle imbalance and pain in spasticity, and prevent joint contractures. One-stage combined procedures have proven considerable advantages over traditional multistage approaches. Immediate activation of transferred muscles reduces the risk of adhesions, facilitates relearning, avoids adverse effects of immobilization, and enhances functional recovery. Transfer of axillary, musculocutaneous, and radial nerve fascicles from above the spinal cord injury are effective and promising options to enhance motor outcome and sensory protection, especially in groups with limited resources. Improved communication between medical disciplines, therapists, patients, and their relatives should help that more individuals can benefit from these advances and could empower many thousands tetraplegic individuals "to take life into their own hands" and live more independently.

  12. Dali server update

    PubMed Central

    Holm, Liisa; Laakso, Laura M.

    2016-01-01

    The Dali server (http://ekhidna2.biocenter.helsinki.fi/dali) is a network service for comparing protein structures in 3D. In favourable cases, comparing 3D structures may reveal biologically interesting similarities that are not detectable by comparing sequences. The Dali server has been running in various places for over 20 years and is used routinely by crystallographers on newly solved structures. The latest update of the server provides enhanced analytics for the study of sequence and structure conservation. The server performs three types of structure comparisons: (i) Protein Data Bank (PDB) search compares one query structure against those in the PDB and returns a list of similar structures; (ii) pairwise comparison compares one query structure against a list of structures specified by the user; and (iii) all against all structure comparison returns a structural similarity matrix, a dendrogram and a multidimensional scaling projection of a set of structures specified by the user. Structural superimpositions are visualized using the Java-free WebGL viewer PV. The structural alignment view is enhanced by sequence similarity searches against Uniprot. The combined structure-sequence alignment information is compressed to a stack of aligned sequence logos. In the stack, each structure is structurally aligned to the query protein and represented by a sequence logo. PMID:27131377

  13. Dali server update.

    PubMed

    Holm, Liisa; Laakso, Laura M

    2016-07-08

    The Dali server (http://ekhidna2.biocenter.helsinki.fi/dali) is a network service for comparing protein structures in 3D. In favourable cases, comparing 3D structures may reveal biologically interesting similarities that are not detectable by comparing sequences. The Dali server has been running in various places for over 20 years and is used routinely by crystallographers on newly solved structures. The latest update of the server provides enhanced analytics for the study of sequence and structure conservation. The server performs three types of structure comparisons: (i) Protein Data Bank (PDB) search compares one query structure against those in the PDB and returns a list of similar structures; (ii) pairwise comparison compares one query structure against a list of structures specified by the user; and (iii) all against all structure comparison returns a structural similarity matrix, a dendrogram and a multidimensional scaling projection of a set of structures specified by the user. Structural superimpositions are visualized using the Java-free WebGL viewer PV. The structural alignment view is enhanced by sequence similarity searches against Uniprot. The combined structure-sequence alignment information is compressed to a stack of aligned sequence logos. In the stack, each structure is structurally aligned to the query protein and represented by a sequence logo.

  14. Updated Principle of Corresponding States

    ERIC Educational Resources Information Center

    Ben-Amotz, Dor; Gift, Alan D.; Levine, R. D.

    2004-01-01

    The rule of corresponding states, which shows the connection between the thermodynamic properties of various liquids is re-examined. The overall likeness is observed by using an updated scaling technique of Lennard-Jones corresponding states (LJ-CS).

  15. Email Updates: MedlinePlus

    MedlinePlus

    ... unsubscribe. Prevent MedlinePlus emails from being marked as "spam" or "junk" To ensure that MedlinePlus email updates ... com to your email address book, adjust your spam settings, or follow the instructions from your email ...

  16. Gearbox Reliability Collaborative Update (Presentation)

    SciTech Connect

    Sheng, S.; Keller, J.; Glinsky, C.

    2013-10-01

    This presentation was given at the Sandia Reliability Workshop in August 2013 and provides information on current statistics, a status update, next steps, and other reliability research and development activities related to the Gearbox Reliability Collaborative.

  17. Argonne Wakefield Accelerator Update `92

    SciTech Connect

    Rosing, M.; Balka, L.; Chojnacki, E.; Gai, W.; Ho, C.; Konecny, R.; Power, J.; Schoessow, P.; Simpson, J.

    1992-09-01

    The Argonne Wakefield Accelerator (AWA) is an experiment designed to test various ideas related to wakefield technology. Construction is now underway for a 100 nC electron beam in December of 1992. This report updates this progress.

  18. Argonne Wakefield Accelerator Update '92

    SciTech Connect

    Rosing, M.; Balka, L.; Chojnacki, E.; Gai, W.; Ho, C.; Konecny, R.; Power, J.; Schoessow, P.; Simpson, J.

    1992-01-01

    The Argonne Wakefield Accelerator (AWA) is an experiment designed to test various ideas related to wakefield technology. Construction is now underway for a 100 nC electron beam in December of 1992. This report updates this progress.

  19. Refraction, including prisms.

    PubMed

    Hiatt, R L

    1991-02-01

    The literature in the past year on refraction is replete with several isolated but very important topics that have been of interest to strabismologists and refractionists for many decades. The refractive changes in scleral buckling procedures include an increase in axial length as well as an increase in myopia, as would be expected. Tinted lenses in dyslexia show little positive effect in the nonasthmatic patients in one study. The use of spectacles or bifocals as a way to control increase in myopia is refuted in another report. It has been shown that in accommodative esotropia not all patients will be able to escape the use of bifocals in the teenage years, even though surgery might be performed. The hope that disposable contact lenses would cut down on the instance of giant papillary conjunctivitis and keratitis has been given some credence, and the conventional theory that sclerosis alone is the cause of presbyopia is attacked. Also, gas permeable bifocal contact lenses are reviewed and the difficulties of correcting presbyopia by this method outlined. The practice of giving an aphakic less bifocal addition instead of a nonaphakic, based on the presumption of increased effective power, is challenged. In the review of prisms, the majority of articles concern prism adaption. The most significant report is that of the Prism Adaptation Study Research Group (Arch Ophthalmol 1990, 108:1248-1256), showing that acquired esotropia in particular has an increased incidence of stable and full corrections surgically in the prism adaptation group versus the control group.(ABSTRACT TRUNCATED AT 250 WORDS)

  20. Minimally invasive splenectomy: an update and review.

    PubMed

    Gamme, Gary; Birch, Daniel W; Karmali, Shahzeer

    2013-08-01

    Laparoscopic splenectomy (LS) has become an established standard of care in the management of surgical diseases of the spleen. The present article is an update and review of current procedures and controversies regarding minimally invasive splenectomy. We review the indications and contraindications for LS as well as preoperative considerations. An individual assessment of the procedures and outcomes of multiport laparoscopic splenectomy, hand-assisted laparoscopic splenectomy, robotic splenectomy, natural orifice transluminal endoscopic splenectomy and single-port splenectomy is included. Furthermore, this review examines postoperative considerations after LS, including the postoperative course of uncomplicated patients, postoperative portal vein thrombosis, infections and malignancy.

  1. Clostridium difficile infection: Updates in management.

    PubMed

    Tariq, Raseen; Khanna, Sahil

    2017-01-01

    Clostridium difficile was first identified in 1978 as a diarrhea-causing bacterium in humans. In the last three decades, C. difficile infection (CDI) has reached an epidemic state, both in health care and community settings worldwide. There has been substantial progress in the field of CDI, including identification of novel risk factors, presence of CDI in individuals not considered at risk previously, and treatment options including new drugs, monoclonal antibodies, and fecal microbiota transplantation. This review discusses epidemiology, novel and traditional risk factors, and updates in management for CDI.

  2. The preparticipation physical examination: an update.

    PubMed

    Seto, Craig K

    2011-07-01

    The evolution of the preparticipation physical examination (PPE) in the United States continues to advance. In May 2010, the fourth edition of the Preparticipation Physical Examination Evaluation (PPE-4) monograph was published. The monograph is a product reflecting the collaborative efforts of 6 author societies. This article provides a brief historical review of the PPE and then highlights the recent changes and updates contained in the PPE-4 monograph, including cardiovascular screening in athletes. New recommendations to include the PPE in all well-child care visits and the need to develop a nationwide standard for the PPE are discussed.

  3. 40 CFR 55.12 - Consistency updates.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Consistency updates. 55.12 Section 55...) OUTER CONTINENTAL SHELF AIR REGULATIONS § 55.12 Consistency updates. (a) The Administrator will update... to update part 55 accordingly. (c) Consistency reviews triggered by receipt of an NOI. Upon...

  4. 77 FR 13198 - Product List Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    ...] Product List Update AGENCY: Postal Regulatory Commission. ACTION: Final rule. SUMMARY: The Commission is... adopted in a recent Commission order. The referenced policy assumes periodic updates. The updates are... these updates. DATES: Effective Date: March 6, 2012. Applicability Dates: February 23, 2012...

  5. STS-51-L Debris Aboard the USGS Cutter Dallas

    NASA Technical Reports Server (NTRS)

    1986-01-01

    On January 28, 1986, the Space Shuttle Challenger and her seven-member crew were lost when a ruptured O-ring in the right Solid Rocket Booster caused an explosion soon after launch. With the help of the U.S. Coast Guard and the U.S. Navy, search and recovery teams began retrieving pieces of the Shuttle from the Atlantic Ocean soon after the accident. Vessels brought the debris to the Trident Basin at Cape Canaveral Air Force Station, where they waited to be shipped to Kennedy Space Center for investigation. The USCG Cutter Dallas transported this fragment of exterior tiling.

  6. CONSULTATION ON UPDATED METHODOLOGY FOR ...

    EPA Pesticide Factsheets

    The National Academy of Sciences (NAS) expects to publish the Biological Effects of Ionizing Radiation (BEIR) committee's report (BEIR VII) on risks from ionizing radiation exposures in calendar year 2005. The committee is expected to have analyzed the most recent epidemiology from the important exposed cohorts and to have factored in any changes resulting from the updated analysis of dosimetry for the Japanese atomic bomb survivors. To the extent practical, the Committee will also consider any relevant radiobiological data, including those from the Department of Energy's low dose effects research program. Based on their evaluation of relevant information, the Committee is then expected to propose a set of models for estimating risks from low-dose ionizing radiation. ORIA will review the BEIR VII report and consider revisions to the Agency's methodology for estimating cancer risks from exposure to ionizing radiation in light of this report and other relevant information. This will be the subject of the Consultation. This project supports a major risk management initiative to improve the basis on which radiation risk decisions are made. This project, funded by several Federal Agencies, reflects an attempt to characterize risks where there are substantial uncertainties. The outcome will improve our ability to assess risks well into the future and will strengthen EPAs overall capability for assessing and managing radiation risks. the BEIR VII report is funde

  7. ADVISORY ON UPDATED METHODOLOGY FOR ...

    EPA Pesticide Factsheets

    The National Academy of Sciences (NAS) published the Biological Effects of Ionizing Radiation (BEIR) committee's report (BEIR VII) on risks from ionizing radiation exposures in 2006. The Committee analyzed the most recent epidemiology from the important exposed cohorts and factored in changes resulting from the updated analysis of dosimetry for the Japanese atomic bomb survivors. To the extent practical, the Committee also considered relevant radiobiological data, including that from the Department of Energy's low dose effects research program. Based on the review of this information, the Committee proposed a set of models for estimating risks from low-dose ionizing radiation. ORIA then prepared a white paper revising the Agency's methodology for estimating cancer risks from exposure to ionizing radiation in light of this report and other relevant information. This is the first product to be developed as a result of the BEIR VII report. We requested that the SAB conduct an advisory during the development of this methodology. The second product to be prepared will be a revised version of the document,

  8. Cannabis and Psychopathology : Update 2004

    PubMed Central

    Grover, Sandeep; Basu, Debasish

    2004-01-01

    The study of cannabis use and psychopathology remains an interesting area from both academic and pragmatic perspectives. This article provides an update on the progress made in this area over the past decade or so. Psychopathology and psychiatric syndromes associated with cannabis use that have received research attention in recent years include cannabis withdrawal, cannabis and psychotic disorders (especially schizophrenia), depression, anxiety, and cognitive impairment. Status of a specific cannabis withdrawal syndrome and a specific ‘cannabis psychosis’ remains controversial. Current evidence indicates that there is a clinically significant association between cannabis use disorders and psychotic syndromes, depression, anxiety and possibly mild cognitive impairment. However, the nature of this association is often not clear. Several hypothesis related to the cannabis-schizophrenia association are examined. Cannabis use might be casually related to the later development of schizophrenia in an indirect way in a few heavy users, but more commonly, its use may precipitate disorders in persons who are vulnerable to developing psychosis and worsen the course of the disorder. PMID:21206788

  9. Updated Evaluations for Americium Isotopes

    SciTech Connect

    Brown, D A; Pruet, J

    2005-09-22

    Here we describe evaluations for Am isotopes that will be included in the next release of ENDL. Current ENDL99 evaluations for these isotopes are quite outdated and almost entirely undocumented. Because Am is important for several DNT applications, and because quality evaluations are either readily available or easily calculated, the effort to update ENDL seems warranted. Results from good existing evaluations are adopted whenever possible. To this end we devote the next section of this report to a consideration of the availability of evaluations The quality of different evaluations as well as comparisons against experiments are also presented and used to motivate our choice of adopted data sets. Plans for modifying and improving adopted evaluations are also discussed. For {sup 240}Am there are no existing evaluations. To fill this gap, we are providing a new Am evaluation based on calculations with the statistical model reaction codes TALYS and EMPIRE. This evaluation is described below. The ENDF/B-VI formatted file containing this evaluation is given in the appendix.

  10. Facial transplantation: A concise update

    PubMed Central

    Barrera-Pulido, Fernando; Gomez-Cia, Tomas; Sicilia-Castro, Domingo; Garcia-Perla-Garcia, Alberto; Gacto-Sanchez, Purificacion; Hernandez-Guisado, Jose-Maria; Lagares-Borrego, Araceli; Narros-Gimenez, Rocio; Gonzalez-Padilla, Juan D.

    2013-01-01

    Objectives: Update on clinical results obtained by the first worldwide facial transplantation teams as well as review of the literature concerning the main surgical, immunological, ethical, and follow-up aspects described on facial transplanted patients. Study design: MEDLINE search of articles published on “face transplantation” until March 2012. Results: Eighteen clinical cases were studied. The mean patient age was 37.5 years, with a higher prevalence of men. Main surgical indication was gunshot injuries (6 patients). All patients had previously undergone multiple conventional surgical reconstructive procedures which had failed. Altogether 8 transplant teams belonging to 4 countries participated. Thirteen partial face transplantations and 5 full face transplantations have been performed. Allografts are varied according to face anatomical components and the amount of skin, muscle, bone, and other tissues included, though all were grafted successfully and remained viable without significant postoperative surgical complications. The patient with the longest follow-up was 5 years. Two patients died 2 and 27 months after transplantation. Conclusions: Clinical experience has demonstrated the feasibility of facial transplantation as a valuable reconstructive option, but it still remains considered as an experimental procedure with unresolved issues to settle down. Results show that from a clinical, technical, and immunological standpoint, facial transplantation has achieved functional, aesthetic, and social rehabilitation in severely facial disfigured patients. Key words:Face transplantation, composite tissue transplantation, face allograft, facial reconstruction, outcomes and complications of face transplantation. PMID:23229268

  11. The updated billion-ton resource assessment

    SciTech Connect

    Turhollow, Anthony; Perlack, Robert; Eaton, Laurence; Langholtz, Matthew; Brandt, Craig; Downing, Mark; Wright, Lynn; Skog, Kenneth; Hellwinckel, Chad; Stokes, Bryce; Lebow, Patricia

    2014-10-03

    This paper summarizes the results of an update to a resource assessment, published in 2005, commonly referred to as the billion-ton study (BTS). The updated results are consistent with the 2005 BTS in terms of overall magnitude. However, in looking at the major categories of feedstocks the forest residue biomass potential was determined to be less owing to tighter restrictions on forest residue supply including restrictions due to limited projected increase in traditional harvest for pulpwood and sawlogs. The crop residue potential was also determined to be less because of the consideration of soil carbon and not allowing residue removal from conventionally tilled corn acres. The energy crop potential was estimated to be much greater largely because of land availability and modeling of competition among various competing uses of the land. Generally, the scenario assumptions in the updated assessment are much more plausible to show a billion-ton resource, which would be sufficient to displace 30% or more of the country s present petroleum consumption.

  12. The updated billion-ton resource assessment

    DOE PAGES

    Turhollow, Anthony; Perlack, Robert; Eaton, Laurence; ...

    2014-10-03

    This paper summarizes the results of an update to a resource assessment, published in 2005, commonly referred to as the billion-ton study (BTS). The updated results are consistent with the 2005 BTS in terms of overall magnitude. However, in looking at the major categories of feedstocks the forest residue biomass potential was determined to be less owing to tighter restrictions on forest residue supply including restrictions due to limited projected increase in traditional harvest for pulpwood and sawlogs. The crop residue potential was also determined to be less because of the consideration of soil carbon and not allowing residue removalmore » from conventionally tilled corn acres. The energy crop potential was estimated to be much greater largely because of land availability and modeling of competition among various competing uses of the land. Generally, the scenario assumptions in the updated assessment are much more plausible to show a billion-ton resource, which would be sufficient to displace 30% or more of the country s present petroleum consumption.« less

  13. Bumper 3 Update for IADC Protection Manual

    NASA Technical Reports Server (NTRS)

    Christiansen, Eric L.; Nagy, Kornel; Hyde, Jim

    2016-01-01

    The Bumper code has been the standard in use by NASA and contractors to perform meteoroid/debris risk assessments since 1990. It has undergone extensive revisions and updates [NASA JSC HITF website; Christiansen et al., 1992, 1997]. NASA Johnson Space Center (JSC) has applied BUMPER to risk assessments for Space Station, Shuttle, Mir, Extravehicular Mobility Units (EMU) space suits, and other spacecraft (e.g., LDEF, Iridium, TDRS, and Hubble Space Telescope). Bumper continues to be updated with changes in the ballistic limit equations describing failure threshold of various spacecraft components, as well as changes in the meteoroid and debris environment models. Significant efforts are expended to validate Bumper and benchmark it to other meteoroid/debris risk assessment codes. Bumper 3 is a refactored version of Bumper II. The structure of the code was extensively modified to improve maintenance, performance and flexibility. The architecture was changed to separate the frequently updated ballistic limit equations from the relatively stable common core functions of the program. These updates allow NASA to produce specific editions of the Bumper 3 that are tailored for specific customer requirements. The core consists of common code necessary to process the Micrometeoroid and Orbital Debris (MMOD) environment models, assess shadowing and calculate MMOD risk. The library of target response subroutines includes a board range of different types of MMOD shield ballistic limit equations as well as equations describing damage to various spacecraft subsystems or hardware (thermal protection materials, windows, radiators, solar arrays, cables, etc.). The core and library of ballistic response subroutines are maintained under configuration control. A change in the core will affect all editions of the code, whereas a change in one or more of the response subroutines will affect all editions of the code that contain the particular response subroutines which are modified. Note

  14. Gap Assessment (FY 13 Update)

    DOE Data Explorer

    Getman, Dan

    2013-09-30

    To help guide its future data collection efforts, The DOE GTO funded a data gap analysis in FY2012 to identify high potential hydrothermal areas where critical data are needed. This analysis was updated in FY2013 and the resulting datasets are represented by this metadata. The original process was published in FY 2012 and is available here: https://pangea.stanford.edu/ERE/db/GeoConf/papers/SGW/2013/Esposito.pdf Though there are many types of data that can be used for hydrothermal exploration, five types of exploration data were targeted for this analysis. These data types were selected for their regional reconnaissance potential, and include many of the primary exploration techniques currently used by the geothermal industry. The data types include: 1. well data 2. geologic maps 3. fault maps 4. geochemistry data 5. geophysical data To determine data coverage, metadata for exploration data (including data type, data status, and coverage information) were collected and catalogued from nodes on the National Geothermal Data System (NGDS). It is the intention of this analysis that the data be updated from this source in a semi-automated fashion as new datasets are added to the NGDS nodes. In addition to this upload, an online tool was developed to allow all geothermal data providers to access this assessment and to directly add metadata themselves and view the results of the analysis via maps of data coverage in Geothermal Prospector (http://maps.nrel.gov/gt_prospector). A grid of the contiguous U.S. was created with 88,000 10-km by 10-km grid cells, and each cell was populated with the status of data availability corresponding to the five data types. Using these five data coverage maps and the USGS Resource Potential Map, sites were identified for future data collection efforts. These sites signify both that the USGS has indicated high favorability of occurrence of geothermal resources and that data gaps exist. The uploaded data are contained in two data files for

  15. Dutch Venous Ulcer guideline update.

    PubMed

    Maessen-Visch, M Birgitte; de Roos, Kees-Peter

    2014-05-01

    The revised guideline of 2013 is an update of the 2005 guideline "venous leg ulcer". In this special project four separate guidelines (venous leg ulcer, varicose veins, compression therapy and deep venous disorders) were revised and developed simultaneously. A meeting was held including representatives of any organisation involved in venous disease management including patient organizations and health insurance companies. Eighteen clinical questions where defined, and a new strategy was used to accelerate the process. This resulted in two new and two revised guidelines within one year. The guideline committee advises use of the C of the CEAP classification as well as the Venous Clinical Severity Score (VCSS) and a Quality of life (QoL) score in the assessment of clinical signs. These can provide insight into the burden of disease and the effects of treatment as experienced by the patient. A duplex ultrasound should be performed in every patient to establish the underlying aetiology and to evaluate the need for treatment (which is discussed in a separate guideline). The use of the TIME model for describing venous ulcers is recommended. There is no evidence for antiseptic or antibiotic wound care products except for a Cochrane review in which some evidence is presented for cadexomer iodine. Signs of infection are the main reason for the use of oral antibiotics. When the ulcer fails to heal the use of oral aspirin and pentoxifylline can be considered as an adjunct. For the individual patient, the following aspects should be considered: the appearance of the ulcer (amount of exudate) according to the TIME model, the influence of wound care products on moisturising the wound, frequency of changing compression bandages, pain and allergies. The cost of the dressings should also be considered. Education and training of patients t improves compliance with compression therapy but does not influence wound healing rates.

  16. Model updating of nonlinear structures from measured FRFs

    NASA Astrophysics Data System (ADS)

    Canbaloğlu, Güvenç; Özgüven, H. Nevzat

    2016-12-01

    There are always certain discrepancies between modal and response data of a structure obtained from its mathematical model and experimentally measured ones. Therefore it is a general practice to update the theoretical model by using experimental measurements in order to have a more accurate model. Most of the model updating methods used in structural dynamics are for linear systems. However, in real life applications most of the structures have nonlinearities, which restrict us applying model updating techniques available for linear structures, unless they work in linear range. Well-established frequency response function (FRF) based model updating methods would easily be extended to a nonlinear system if the FRFs of the underlying linear system (linear FRFs) could be experimentally measured. When frictional type of nonlinearity co-exists with other types of nonlinearities, it is not possible to obtain linear FRFs experimentally by using low level forcing. In this study a method (named as Pseudo Receptance Difference (PRD) method) is presented to obtain linear FRFs of a nonlinear structure having multiple nonlinearities including friction type of nonlinearity. PRD method, calculates linear FRFs of a nonlinear structure by using FRFs measured at various forcing levels, and simultaneously identifies all nonlinearities in the system. Then, any model updating method can be used to update the linear part of the mathematical model. In this present work, PRD method is used to predict the linear FRFs from measured nonlinear FRFs, and the inverse eigensensitivity method is employed to update the linear finite element (FE) model of the nonlinear structure. The proposed method is validated with different case studies using nonlinear lumped single-degree of freedom system, as well as a continuous system. Finally, a real nonlinear T-beam test structure is used to show the application and the accuracy of the proposed method. The accuracy of the updated nonlinear model of the

  17. Editorial update on emerging treatments of atopic dermatitis.

    PubMed

    Ong, Peck Y

    2012-06-01

    Various new agents are in the research pipeline for atopic dermatitis. These include IL-4 receptor antagonist, cis-urocanic acid, κ-opiod receptor agonist, neurokinin receptor antagonist and antimicrobial peptide. The current review updates the status of these clinical trials and provides insight into other potential molecular targets including IL-22 and TLR-2.

  18. Updated Electronic Testbed System

    NASA Technical Reports Server (NTRS)

    Brewer, Kevin L.

    2001-01-01

    updated Electronic Testbed System.

  19. Science Update: Inorganic Chemistry.

    ERIC Educational Resources Information Center

    Rawls, Rebecca

    1981-01-01

    Describes areas of inorganic chemistry which have changed dramatically in the past year or two, including photochemistry, electrochemistry, organometallic complexes, inorganic reaction theory, and solid state chemistry. (DS)

  20. Recommendations of diagnosis and treatment of pleural effusion. Update.

    PubMed

    Villena Garrido, Victoria; Cases Viedma, Enrique; Fernández Villar, Alberto; de Pablo Gafas, Alicia; Pérez Rodríguez, Esteban; Porcel Pérez, José Manuel; Rodríguez Panadero, Francisco; Ruiz Martínez, Carlos; Salvatierra Velázquez, Angel; Valdés Cuadrado, Luis

    2014-06-01

    Although during the last few years there have been several important changes in the diagnostic or therapeutic methods, pleural effusion is still one of the diseases that the respiratory specialist have to evaluate frequently. The aim of this paper is to update the knowledge about pleural effusions, rather than to review the causes of pleural diseases exhaustively. These recommendations have a longer extension for the subjects with a direct clinical usefulness, but a slight update of other pleural diseases has been also included. Among the main scientific advantages are included the thoracic ultrasonography, the intrapleural fibrinolytics, the pleurodesis agents, or the new pleural drainages techniques.

  1. Xanthones of Lichen Source: A 2016 Update.

    PubMed

    Le Pogam, Pierre; Boustie, Joël

    2016-03-02

    An update of xanthones encountered in lichens is proposed as more than 20 new xanthones have been described since the publication of the compendium of lichen metabolites by Huneck and Yoshimura in 1996. The last decades witnessed major advances regarding the elucidation of biosynthetic schemes leading to these fascinating compounds, accounting for the unique substitution patterns of a very vast majority of lichen xanthones. Besides a comprehensive analysis of the structures of xanthones described in lichens, their bioactivities and the emerging analytical strategies used to pinpoint them within lichens are presented here together with physico-chemical properties (including NMR data) as reported since 1996.

  2. Citicoline: pharmacological and clinical review, 2010 update.

    PubMed

    Secades, J J

    2011-03-14

    This review is based on the previous one published in 2006 -Secades JJ, Lorenzo JL. Citicoline: pharmacological and clinical review, 2006 update. Methods Find Exp Clin Pharmacol 2006; 28 (Suppl B): S1-56-, incorporating the new references until now, having all the information available to facilitate the access to the informacion in one document. This review is focused on the main indications of the drug, as acute stroke and its sequelae, including the cognitive impairment, and traumatic brain injury and its sequelae. There are retrieved the most important experimental and clinical data in both indications.

  3. Lung stem cell update: promise and controversy.

    PubMed

    Neuringer, I P; Randell, S H

    2006-03-01

    Currently, there is great enthusiasm about potential stem cell therapies for intractable diseases. We previously reviewed the topic of stem cells in lung injury and repair, including the role of endogenous, tissue (somatic) stem cells and the contribution of circulating cells to the lung parenchyma. Our purpose here is to provide a concise update in this fast-moving field. New information and ongoing debate focus attention on basic issues in lung stem cell biology and highlight the need for additional studies to establish the feasibility of cell therapies to prevent or treat lung diseases.

  4. Computer virus information update CIAC-2301

    SciTech Connect

    Orvis, W.J.

    1994-01-15

    While CIAC periodically issues bulletins about specific computer viruses, these bulletins do not cover all the computer viruses that affect desktop computers. The purpose of this document is to identify most of the known viruses for the MS-DOS and Macintosh platforms and give an overview of the effects of each virus. The authors also include information on some windows, Atari, and Amiga viruses. This document is revised periodically as new virus information becomes available. This document replaces all earlier versions of the CIAC Computer virus Information Update. The date on the front cover indicates date on which the information in this document was extracted from CIAC`s Virus database.

  5. SSC design update

    SciTech Connect

    Syphers, M.J.

    1992-11-01

    Recent developments in the design and construction of the SSC are presented. Topics include status of the 20 TeV Collider rings, including interaction regions, utility regions, and main arcs, plus some remarks on the injector accelerators. Remaining issues facing the design of the colliding beams synchrotron and its injectors are discussed.

  6. School Law Update, 1985.

    ERIC Educational Resources Information Center

    Jones, Thomas N., Ed.; Semler, Darel P., Ed.

    A wide variety of contemporary legal issues, involving all levels of public and private education, are addressed in the 20 papers in this volume. Written in law review style and including legal citations, the papers and authors included are: (1) "Who Runs the Schools" (Flygare); (2) "Copyright Issues in Computer-Assisted…

  7. Normal response function method for mass and stiffness matrix updating using complex FRFs

    NASA Astrophysics Data System (ADS)

    Pradhan, S.; Modak, S. V.

    2012-10-01

    Quite often a structural dynamic finite element model is required to be updated so as to accurately predict the dynamic characteristics like natural frequencies and the mode shapes. Since in many situations undamped natural frequencies and mode shapes need to be predicted, it has generally been the practice in these situations to seek updating of only mass and stiffness matrix so as to obtain a reliable prediction model. Updating using frequency response functions (FRFs) has been one of the widely used approaches for updating, including updating of mass and stiffness matrices. However, the problem with FRF based methods, for updating mass and stiffness matrices, is that these methods are based on use of complex FRFs. Use of complex FRFs to update mass and stiffness matrices is not theoretically correct as complex FRFs are not only affected by these two matrices but also by the damping matrix. Therefore, in situations where updating of only mass and stiffness matrices using FRFs is required, the use of complex FRFs based updating formulation is not fully justified and would lead to inaccurate updated models. This paper addresses this difficulty and proposes an improved FRF based finite element model updating procedure using the concept of normal FRFs. The proposed method is a modified version of the existing response function method that is based on the complex FRFs. The effectiveness of the proposed method is validated through a numerical study of a simple but representative beam structure. The effect of coordinate incompleteness and robustness of method under presence of noise is investigated. The results of updating obtained by the improved method are compared with the existing response function method. The performance of the two approaches is compared for cases of light, medium and heavily damped structures. It is found that the proposed improved method is effective in updating of mass and stiffness matrices in all the cases of complete and incomplete data and

  8. Updated Guidelines for ANSS Instruments

    NASA Astrophysics Data System (ADS)

    Evans, J. R.; Hutt, C. R.; Gee, L. S.

    2014-12-01

    In 2008 the Advanced National Seismic System (ANSS) of the U.S. Geological Survey (USGS) and cooperating universities and institutions issued USGS Open-File Report 2008-1262 (OFR) containing detailed guidelines for the performance of instrumentation to be used by the ANSS. Here we report an update underway to these guidelines to take account of lessons learned, changing technology, and expanding user desires; in a few instances, performance matters that are very hard to test in practice are either modified or removed. Instrument classes are defined in the OFR in terms of amplitude resolution and cost; because relevant technologies have advanced substantially in these six years and a number of groups have begun to explore the use of relatively inexpensive, entirely host installed and operated Class C systems, the guidelines for strong-motion sensors are being expanded to include detailed guidelines for them rather than just anticipating them. As always, Class A systems will form the state-of-the-art backbone of any network, with Class B filling in spatially and in areas otherwise not covered well. Class C systems would be an additional step in making networks denser by providing very inexpensive hardware, installation, and maintenance to fill in additionally between Class A and B sites, for example in a high-seismicity urban area, with Class A sites every 4-6 km, Class B every 2-3 km, and Class C at <1 km spacing. Class C devices would be both installed and maintained by hosts, not institutions, and therefore also would be economical for extending coverage in regions with widely spaced or rare large seismicity, such as the central and eastern U.S.

  9. Measurement updating using the U-D factorization. [for Kalman matrix filter error covariance

    NASA Technical Reports Server (NTRS)

    Bierman, G. J.

    1975-01-01

    A new mechanization of the Kalman updating algorithm based on a U-D factorization of the estimate error covariance is introduced. Efficient and stable updating recursions are developed for the unit upper triangular factor U and the diagonal factor D, treating only the parameter estimation problem. Properties of the factorization update performed here include efficient one point at a time processing that requires little more computation than the optimal but numerically unstable conventional Kalman measurement update algorithm, and stability that compares with the square root filter.

  10. [Preoperative fasting guidelines: an update].

    PubMed

    López Muñoz, A C; Busto Aguirreurreta, N; Tomás Braulio, J

    2015-03-01

    Anesthesiology societies have issued various guidelines on preoperative fasting since 1990, not only to decrease the incidence of lung aspiration and anesthetic morbidity, but also to increase patient comfort prior to anesthesia. Some of these societies have been updating their guidelines, as such that, since 2010, we now have 2 evidence-based preoperative fasting guidelines available. In this article, an attempt is made to review these updated guidelines, as well as the current instructions for more controversial patients such as infants, the obese, and a particular type of ophthalmic surgery.

  11. Ferrium S53 LG Update

    DTIC Science & Technology

    2008-02-01

    Ferrium S53 LG Update Charles J. Kuehmann Surface Finishing and Repair Issues for Sustaining New Military Aircraft Tempe, AZ February 26-28, 2008...2008 2. REPORT TYPE 3. DATES COVERED 00-00-2008 to 00-00-2008 4. TITLE AND SUBTITLE Ferrium S53 LG Update 5a. CONTRACT NUMBER 5b. GRANT... Ferrium S53 : A Nanostructured UHS Corrosion-Resistant Steel Accidents by Aircraft System Commercial Jet Transport Aircraft 1958-1993 456 192 185 100 85 49

  12. Perchlorate Treatment Technology Update

    EPA Pesticide Factsheets

    This issue paper has been prepared by EPA's Federal Facilities Forum to provide information about technologies available for treatment of perchlorate contamination in environmental media, including technologies that have been used to date and others that..

  13. Nutrition Update, 1978.

    ERIC Educational Resources Information Center

    Weininger, Jean; Briggs, George M.

    1978-01-01

    Reviews current nutrition research areas with important practical applications. Topics include hypertension, preventable birth defects, phenylketonuria and genetic diseases, new molecular genetics techniques, and saccharin and sweetners. Entries are brief and a 65-reference list is given. (MA)

  14. Science Update: Inorganic Chemistry

    ERIC Educational Resources Information Center

    Rawls, Rebecca

    1978-01-01

    This first in a series of articles describing the state of the art of various branches of chemistry reviews inorganic chemistry, including bioinorganic, photochemistry, organometallic, and solid state chemistries. (SL)

  15. Maintenance Management Update.

    ERIC Educational Resources Information Center

    Sternloff, Robert E.

    1987-01-01

    Current trends in park maintenance are overviewed, including maintenance impact statements, avoidance of cost through efficient use and national resource conservation, horticultural accomplishments that influence maintenance management, and vandalism prevention. (CB)

  16. Atrazine - Background and Updates

    EPA Pesticide Factsheets

    Atrazine is a widely used herbicide that can be applied before and after planting to control broadleaf and grassy weeds. Atrazine is part of the triazine chemical class which includes simazine and propazine due to their common mechanism of toxicity.

  17. ISS Update: Smart SPHERES

    NASA Video Gallery

    NASA Public Affairs Officer Kelly Humphries conducts a phone interview with Mark Micire, SPHERES Engineering Manager at Ames Research Center. Questions? Ask us on Twitter @NASA_Johnson and include ...

  18. Environmental Health Research Update

    ERIC Educational Resources Information Center

    Ember, Lois R.

    1977-01-01

    Describes recommendations of a task force formed under the auspices of the National Institute of Environmental Health Sciences, including more standardized procedures for collecting and evaluating environmental data. (MLH)

  19. ISS Update: Supermoon

    NASA Video Gallery

    Public Affairs Officer Kyle Herring narrates video of the "supermoon" captured from the International Space Station during Expedition 31. Questions? Ask us on Twitter @NASA_Johnson and include the ...

  20. Update in adolescent dermatology.

    PubMed

    Feinberg, Arthur N; Shwayder, Tor A

    2013-04-01

    This dermatology article serves as a quick reference for the physician treating adolescents. We first review the diagnostic approach to a dermatologic problem: configuration, color, pattern, and distribution. The next section discusses diagnosis and management of the most common clinical situations encountered in everyday practice, including skin infections, infestations, dermatitis, hypersensitivity reactions, and papulosquamous disorders. The following section covers conditions that should be managed with the help of a dermatologist, including difficult acute situations such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and necrotizing fasciitis; other chronic situations, including refractory common conditions such as acne and psoriasis, are also considered. We then discuss conditions that should be managed exclusively by a dermatologist, including malignancies, bullous disorders, and less common types of ichthyosis. The final section alerts the physician to dermatologic conditions that may be manifestations of other disorders, necessitating appropriate referral to a different specialist. Examples are immunologic and endocrine disorders, inflammatory bowel disease, collagen vascular disease, and malignancies.

  1. 78 FR 76738 - Updated Statements of Legal Authority for the Export Administration Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...This rule updates the Code of Federal Regulations (CFR) legal authority paragraphs in the Export Administration Regulations (EAR) to include the citations to five Presidential notices extending emergencies declared pursuant to the International Emergency Economic Powers Act. This is a procedural rule that only updates authority paragraphs of the EAR. It does not alter any right, obligation or......

  2. Comprehensive Thematic T-matrix Reference Database: a 2013-2014 Update

    NASA Technical Reports Server (NTRS)

    Mishchenko, Michael I.; Zakharova, Nadezhda T.; Khlebtsov, Nikolai G.; Wriedt, Thomas; Videen, Gorden

    2014-01-01

    This paper is the sixth update to the comprehensive thematic database of peer-reviewedT-matrix publications initiated by us in 2004 and includes relevant publications that have appeared since 2013. It also lists several earlier publications not incorporated in the original database and previous updates.

  3. An Annotated and Updated Species List of the Coccinellidae (Coleoptera) of South Dakota

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An updated list of 79 species of Coccinellidae for South Dakota is presented. The list represents a net increase in the state coccinellid fauna from a previously published list of 66 species and subspecific taxa, and it also includes nomenclatural updates. Thirteen species have been added to the l...

  4. Trends in College Spending: 2001-2011. A Delta Data Update

    ERIC Educational Resources Information Center

    Desrochers, Donna M.; Hurlburt, Steven

    2014-01-01

    This "Trends in College Spending" update presents national-level estimates for the "Delta Cost Project" data metrics during the period 2001-11. To accelerate the release of more current trend data, however, this update includes only a brief summary of the financial patterns and trends observed during the decade 2001-11, with…

  5. 42 CFR 412.428 - Publication of Updates to the inpatient psychiatric facility prospective payment system.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Publication of Updates to the inpatient psychiatric... Psychiatric Facilities § 412.428 Publication of Updates to the inpatient psychiatric facility prospective... inpatient psychiatric facility prospective payment system. This information includes: (a) A description...

  6. 42 CFR 412.428 - Publication of Updates to the inpatient psychiatric facility prospective payment system.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Publication of Updates to the inpatient psychiatric... Psychiatric Facilities § 412.428 Publication of Updates to the inpatient psychiatric facility prospective... inpatient psychiatric facility prospective payment system. This information includes: (a) A description...

  7. 42 CFR 412.428 - Publication of Updates to the inpatient psychiatric facility prospective payment system.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Publication of Updates to the inpatient psychiatric... Psychiatric Facilities § 412.428 Publication of Updates to the inpatient psychiatric facility prospective... inpatient psychiatric facility prospective payment system. This information includes: (a) A description...

  8. 42 CFR 412.428 - Publication of Updates to the inpatient psychiatric facility prospective payment system.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Publication of Updates to the inpatient psychiatric... Psychiatric Facilities § 412.428 Publication of Updates to the inpatient psychiatric facility prospective... inpatient psychiatric facility prospective payment system. This information includes: (a) A description...

  9. Endocarditis 2014: an update.

    PubMed

    Thanavaro, Kristin L; Nixon, J V Ian

    2014-01-01

    The epidemiology of infective endocarditis is changing due to a number of factors, including more frequent and varied antibiotic use, the emergence of resistant microorganisms, and an increase in the implantation of cardiovascular devices. This review outlines and consolidates the most recent guidelines, including the 2007 and 2010 AHA/ACC guidelines and scientific statements for the prevention and management of infective endocarditis and for the management of cardiovascular device infections. The evidence-based guidelines, including the 2009 HRS consensus document, for the treatment of patients with cardiovascular device-related infections are also reviewed. Only patients with prosthetic valves, patients with prior endocarditis, cardiac transplant patients with a valvulopathy, and certain congenital heart disease patients now require endocarditis prophylaxis. There is an increasing incidence of cardiovascular device-related infections due to the higher frequency of implanted devices and higher morbidity and mortality rates in older patients.

  10. Program Updates - San Antonio River Basin

    EPA Pesticide Factsheets

    This page will house updates for this urban waters partnership location. As projects progress, status updates can be posted here to reflect the ongoing work by partners in San Antonio working on the San Antonio River Basin.

  11. Breast Cancer and Estrogen-Alone Update

    MedlinePlus

    ... Current Issue Past Issues Research News From NIH Breast Cancer and Estrogen-Alone Update Past Issues / Summer 2006 ... hormone therapy does not increase the risk of breast cancer in postmenopausal women, according to an updated analysis ...

  12. Seborrheic dermatitis: an update.

    PubMed

    Bukvić Mokos, Zrinka; Kralj, Martina; Basta-Juzbašić, Aleksandra; Lakoš Jukić, Ines

    2012-01-01

    Seborrheic dermatitis is a chronic relapsing inflammatory skin disorder clinically characterized by scaling and poorly defined erythematous patches. The prevalence of adult seborrheic dermatitis is estimated at 5%. Although the exact cause of seborrheic dermatitis has yet to be understood, Malassezia yeasts, hormones (androgens), sebum levels and immune response are known to play important roles in its development. Additional factors including drugs, winter temperatures and stress may exacerbate seborrheic dermatitis. A variety of treatment modalities are available, including antifungal agents, topical low-potency steroids and calcineurin inhibitors (immunomodulators). This review summarizes current knowledge on the etiopathogenesis and therapy of adult seborrheic dermatitis.

  13. An Update on the CDDIS

    NASA Technical Reports Server (NTRS)

    Noll, Carey; Michael, Patrick; Dube, Maurice P.; Pollack, N.

    2012-01-01

    incoming data and product files pushed to its archive. This poster will include background information about the system and its user communities, archive contents and updates, enhancements for data discovery, new system architecture, and future plans.

  14. Task Group 9 Update (Presentation)

    SciTech Connect

    Bosco, N.

    2014-04-01

    This presentation is a brief update of IEC TC82 QA Task Force, Group 9. Presented is an outline of the recently submitted New Work Item Proposal (NWIP) for a Comparative Thermal Cycling Test for CPV Modules to Differentiate Thermal Fatigue Durability.

  15. NUHOMS{reg_sign} update

    SciTech Connect

    Rich, N.

    1995-12-31

    NUHOMS{reg_sign} is the dry spent fuel storage and transportation technology selected to date by the majority of commercial nuclear utilities. The author first gives a system overview of the NUHOMS{reg_sign}. Next she discusses the project status and licensing status. She closes with an update of the multi-purpose canister.

  16. Progress Update: Stack Project Complete

    ScienceCinema

    Cody, Tom

    2016-07-12

    Progress update from the Savannah River Site. The 75 foot 293 F Stack, built for plutonium production, was cut down to size in order to prevent injury or release of toxic material if the structure were to collapse due to harsh weather.

  17. Early Childhood Update, Fall 1995.

    ERIC Educational Resources Information Center

    Kimmerly, Lynn, Ed.

    1995-01-01

    This newsletter provides a periodic update on the activities of the Early Childhood Research Working Group (ECRWG), organized in early 1995 by the U.S. Department of Education and other federal government departments and agencies to promote interagency cooperation and public-private partnerships in early childhood research. This edition contains…

  18. National Drug Control Strategy. Update

    ERIC Educational Resources Information Center

    Office of National Drug Control Policy, 2005

    2005-01-01

    The first National Drug Control Strategy set ambitious two and five-year performance based goals: (1) to lower the rate of drug use by 10 percent over 2 years among both youth and adults; and (2) to lower the rate by 25 percent over 5 years. The chapters in this updated version are keyed to the strategies three priorities: (1) Stopping Use Before…

  19. One-dimensional model update

    SciTech Connect

    Wuebbles, D.J.; Penner, J.E.; Tarp, R.L.

    1981-01-01

    Changes were made in the reaction kinetics constants for the atmospheric chemistry model. The CH/sub 3/CCl/sub 3/ emission rate was changed to 10/sup 9/ lb/y. Values for the solar flux vs wavelength were updated. Solar variability is discussed. Effects of clouds on photolysis rates are considered. (DLC)

  20. Anterior cruciate ligament - updating article.

    PubMed

    Luzo, Marcus Vinicius Malheiros; Franciozi, Carlos Eduardo da Silveira; Rezende, Fernando Cury; Gracitelli, Guilherme Conforto; Debieux, Pedro; Cohen, Moisés

    2016-01-01

    This updating article on the anterior cruciate ligament (ACL) has the aim of addressing some of the most interesting current topics in this field. Within this stratified approach, it contains the following sections: ACL remnant; anterolateral ligament and combined intra and extra-articular reconstruction; fixation devices; and ACL femoral tunnel creation techniques.

  1. NACRE Update and Extension Project

    SciTech Connect

    Aikawa, Masayuki; Arnould, Marcel; Takahashi, Kohji; Arai, Koji; Utsunomiya, Hiroaki

    2006-04-26

    NACRE, the 'nuclear astrophysics compilation of reaction rates', has been widely utilized in stellar evolution and nucleosynthesis studies since its publication in 1999. We describe here the current status of a Konan-Universite Libre de Brussels (ULB) joint project that aims at its update and extension.

  2. Vitamin E: Textbooks Require Updating

    ERIC Educational Resources Information Center

    Azzi, Angelo; Zingg, Jean-Marc

    2005-01-01

    Vitamin E was discovered in 1922, but in more than 60 years many new findings have added to the early one. However, its description in many textbooks has not been proportionally updated. The result is an inaccurate, incomplete, and often incorrect description of the function of this vitamin. In some other textbooks, vitamin E is absolutely…

  3. Progress Update: Stack Project Complete

    SciTech Connect

    Cody, Tom

    2010-01-01

    Progress update from the Savannah River Site. The 75 foot 293 F Stack, built for plutonium production, was cut down to size in order to prevent injury or release of toxic material if the structure were to collapse due to harsh weather.

  4. Austin Community College Benchmarking Update.

    ERIC Educational Resources Information Center

    Austin Community Coll., TX. Office of Institutional Effectiveness.

    Austin Community College contracted with MGT of America, Inc. in spring 1999 to develop a peer and benchmark (best) practices analysis on key indicators. These indicators were updated in spring 2002 using data from eight Texas community colleges and four non-Texas institutions that represent large, comprehensive, urban community colleges, similar…

  5. Deductive Updating Is Not Bayesian

    ERIC Educational Resources Information Center

    Markovits, Henry; Brisson, Janie; de Chantal, Pier-Luc

    2015-01-01

    One of the major debates concerning the nature of inferential reasoning is between counterexample-based theories such as mental model theory and probabilistic theories. This study looks at conclusion updating after the addition of statistical information to examine the hypothesis that deductive reasoning cannot be explained by probabilistic…

  6. Legal Update of Gifted Education

    ERIC Educational Resources Information Center

    Zirkel, Perry A.

    2016-01-01

    This update of the legislation/regulations and case law specific to pre-K-12 gifted students since a cluster of publications in 2004-2005 primarily focuses on the "gifted alone" category, with only secondary attention to twice-exceptional and other students in the "gifted plus" category. For the gifted-alone category, the…

  7. A Mathematics Software Database Update.

    ERIC Educational Resources Information Center

    Cunningham, R. S.; Smith, David A.

    1987-01-01

    Contains an update of an earlier listing of software for mathematics instruction at the college level. Topics are: advanced mathematics, algebra, calculus, differential equations, discrete mathematics, equation solving, general mathematics, geometry, linear and matrix algebra, logic, statistics and probability, and trigonometry. (PK)

  8. Competitive Electricity Prices: An Update

    EIA Publications

    1998-01-01

    Illustrates a third impact of the move to competitive generation pricing -- the narrowing of the range of prices across regions of the country. This feature article updates information in Electricity Prices in a Competitive Environment: Marginal Cost Pricing of Generation Services and Financial Status of Electric Utilities.

  9. National Educators' Workshop: Update 1996

    NASA Technical Reports Server (NTRS)

    Gardner, James E.; Freeman, Ginger L.; Jacobs, James; Parkin, Don M.

    1997-01-01

    This document contains a collection of experiments presented and demonstrated at the National Educators' Workshop: Update 96, held at Los Alamos National Laboratory, Los Alamos, New Mexico on October 27-30, 1996. The experiments related to the nature and properties of engineering materials and provided information to assist in teaching about materials in the education community.

  10. Update on hand hygiene.

    PubMed

    Boyce, John M

    2013-05-01

    Recent developments related to hand hygiene include new test methods for evaluating hand hygiene products, improvements in alcohol-based hand rubs, novel methods of hand antisepsis, and new strategies and technologies for monitoring hand hygiene practices among health care personnel.

  11. Computer Viruses. Technology Update.

    ERIC Educational Resources Information Center

    Ponder, Tim, Comp.; Ropog, Marty, Comp.; Keating, Joseph, Comp.

    This document provides general information on computer viruses, how to help protect a computer network from them, measures to take if a computer becomes infected. Highlights include the origins of computer viruses; virus contraction; a description of some common virus types (File Virus, Boot Sector/Partition Table Viruses, Trojan Horses, and…

  12. Update on pediatric hyperhidrosis.

    PubMed

    Gordon, Jennifer R S; Hill, Samantha E

    2013-01-01

    Hyperhidrosis is a common and under-recognized disease in the pediatric population that has a significant impact on quality of life. Focal and generalized forms of hyperhidrosis exist, which can be idiopathic or secondary to underlying medical conditions or medications. Treatment is tailored to the specific patient needs, characteristics and goals. These include topical preparations, iontophoresis, botulinum toxin and anticholinergic medications.

  13. Positron annihilation processes update

    NASA Technical Reports Server (NTRS)

    Guessoum, Nidhal; Skibo, Jeffrey G.; Ramaty, Reuven

    1997-01-01

    The present knowledge concerning the positron annihilation processes is reviewed, with emphasis on the data of the cross sections of the various processes of interest in astrophysical applications. Recent results are presented including results on reaction rates and line widths, the validity of which is verified.

  14. Document Delivery Update.

    ERIC Educational Resources Information Center

    Nelson, Nancy Melin

    1992-01-01

    Presents highlights of research that used industrywide surveys, focus groups, personal interviews, and industry-published data to explore the future of electronic information delivery in libraries. Topics discussed include CD-ROMs; prices; full-text products; magnetic tape leasing; engineering and technical literature; connections between online…

  15. Career Update: Moving Up.

    ERIC Educational Resources Information Center

    Thomas, Irene Middleman

    1992-01-01

    Discusses corporate hiring and promotion of Hispanic Americans. Interview respondents discuss their Hispanic backgrounds, education, and corporate practices that helped advance their careers. Subjects include executives at SmithKline Beecham (Philadelphia), IBM, John F. Kennedy School of Government (Harvard), Aetna Life and Casualty, and Chase…

  16. Update: Saudi Arabia.

    ERIC Educational Resources Information Center

    McGregor, Joy; Nydell, Margaret

    A guide for persons planning on living in or relocating to Saudi Arabia for extended periods of time, this book features information on such topics as entry requirements, transportation, money matters, housing, schools, and insurance. The guide's contents include the following sections: (1) an overview; (2) before leaving; (3) on arrival; (4)…

  17. Student Leadership. Prevention Updates

    ERIC Educational Resources Information Center

    Langford, Linda; DeJong, William

    2010-01-01

    Campus-based efforts to reduce alcohol and other drug abuse and violence (AODV) will be more successful if they involve a wide range of stakeholders--including students--who can contribute to the program's design, implementation, and evaluation. Students provide a unique perspective on AODV prevention, and they can also bring a certain authority…

  18. Annual Hypermedia Update.

    ERIC Educational Resources Information Center

    Jones, Robert Alun; And Others

    1990-01-01

    These three articles discuss the use of hypertext and hypermedia systems in higher education. Topics addressed include knowledge acquisition; learning processes; access to information (highlighting the printing press, subject specialists, and broadcast media); the Perseus Project; authoring tools; incorporating hypermedia within courseware; user…

  19. RCC NDE Update

    NASA Technical Reports Server (NTRS)

    Hernandez, Jose M.

    2004-01-01

    This slide presentation reviews non-destructive evaluation (NDE) techniques of Reinforced Carbon-Carbon (RCC) materials and the progress involved in bringing the technology to technological maturity. Included is information about the test specimens, thermographic, ultrasonic, eddy current, and radiographic inspection of RCC materials.

  20. Bowland Maths--Update

    ERIC Educational Resources Information Center

    Thompson, Quentin

    2011-01-01

    The March issue of "Mathematics Teaching" included an article by Alice Onion about Bowland Maths, focussing on the nature and use of the Professional Development modules that the Bowland Trust has developed--there are now seven such CPD modules on the Bowland website. The article also mentioned that the Bowland Trust had recently…

  1. Update Hong Kong.

    ERIC Educational Resources Information Center

    Bennett, Martin F.

    This book is a guide intended for persons planning on relocating to Hong Kong. Following an overview of the history and culture of Hong Kong, 12 additional chapters lead the reader step-by-step through the relocation process. These chapter topics include: before leaving, on arrival, language, doing business in Hong Kong, customs and courtesies,…

  2. Laptop Program Update

    ERIC Educational Resources Information Center

    Livingston, Pamela

    2006-01-01

    Visitors to the Peck School this year would see a very different scene than two years ago. The school has expanded its laptop program to include younger students, begun construction on two new buildings, and revamped the daily schedule. Laptops are moving into the lower grades, with younger students at a ratio of two students per computer and…

  3. 40 CFR 68.190 - Updates.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Updates. 68.190 Section 68.190... ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.190 Updates. (a) The owner or operator shall review and update the RMP as specified in paragraph (b) of this section and submit it in the method...

  4. Space Shuttle development update

    NASA Technical Reports Server (NTRS)

    Brand, V.

    1984-01-01

    The development efforts, since the STS-4 flight, in the Space Shuttle (SS) program are presented. The SS improvements introduced in the last two years include lower-weight loads, communication through the Tracking and Data Relay Satellite, expanded extravehicular activity capability, a maneuvering backpack and the manipulator foot restraint, the improvements in thermal projection system, the 'optional terminal area management targeting' guidance software, a rendezvous system with radar and star tracker sensors, and improved on-orbit living conditions. The flight demonstrations include advanced launch techniques (e.g., night launch and direct insertion to orbit); the on-orbit demonstrations; and added entry and launching capabilities. The entry aerodynamic analysis and entry flight control fine tuning are described. Reusability, improved ascent performance, intact abort and landing flexibility, rollout control, and 'smart speedbrakes' are among the many improvements planned for the future.

  5. Thalassaemia Intermedia: an Update

    PubMed Central

    Taher, Ali T.; Musallam, Khaled M.; Cappellini, Maria D.

    2009-01-01

    Our understanding of the molecular and pathophysiological mechanisms underlying the disease process in patients with thalassaemia intermedia (TI) has substantially increased over the past decade. TI encompasses a wide clinical spectrum of beta-thalassaemia phenotypes. Some TI patients are asymptomatic until adult life, whereas others are symptomatic from as young as 2 years of age. A number of clinical complications commonly associated with TI are rarely seen in thalassaemia major, including extramedullary hematopoiesis, leg ulcers, gallstones, thrombosis and pulmonary hypertension. There are a number of options currently available for managing patients with TI, including transfusion therapy, iron chelation therapy, modulation of foetal haemoglobin production and haematopoietic stem cell transplantation. However, at present, there are no clear guidelines for an orchestrated optimal treatment plan. PMID:21415986

  6. Wet storage integrity update

    SciTech Connect

    Bailey, W.J.; Johnson, A.B. Jr.

    1983-09-01

    This report includes information from various studies performed under the Wet Storage Task of the Spent Fuel Integrity Project of the Commercial Spent Fuel Management (CSFM) Program at Pacific Northwest Laboratory. An overview of recent developments in the technology of wet storage of spent water reactor fuel is presented. Licensee Event Reports pertaining to spent fuel pools and the associated performance of spent fuel and storage components during wet storage are discussed. The current status of fuel that was examined under the CSFM Program is described. Assessments of the effect of boric acid in spent fuel pool water on the corrosion and stress corrosion cracking of stainless steel and the stress corrosion cracking of stainless steel piping containing stagnant water at spent fuel pools are discussed. A list of pertinent publications is included. 84 references, 21 figures, 11 tables.

  7. Update. Llama nutrition.

    PubMed

    Johnson, L W

    1994-07-01

    An understanding and appreciation of the New World Camelids' unique gastric anatomy and physiology, including rapid motility, prolonged digesta retention, rapid liquid passage rate, low protein maintenance requirements, low metabolized energy requirements, and low basal metabolism are imperative. Using this background, feeding recommendations for growing male llamas are proposed, and some suggestions are made concerning nutritional considerations of NWCs during the neonatal period, lactation, pregnancy, and work.

  8. Update on INSIGHTS Development

    SciTech Connect

    Not Listed; Eric Burgett

    2011-09-01

    INSIGHTS is a transformational separate effects testing capability to perform in situ irradiation studies and characterization of the microscale behavior of nuclear fuel materials under a wide variety of in-pile conditions. Separate effects testing including growth, irradiation, and monitoring of these materials, and encompasses the full science based approach for fuels development from the nanoscale to the mesoscale behavior of the sample material and other defects driven by the modeling and simulation efforts of INL.

  9. Rett Syndrome -- an update.

    PubMed

    Jellinger, K A

    2003-06-01

    Rett syndrome is a progressive, usually sporadic and rarely familial, disabling neurodevelopmental disorder with onset in early childhood presenting clinically with mental retardation, behavioral changes, late movement disturbances, loss of speech and hand skills, ataxia, apraxia, irregular breathing with hyperventilation while awake, and frequent seizures. It occurs almost exclusively in females with an estimated prevalence of 1 in 10-22000 births and is considered a manifestation of defective brain maturation caused by dominant mutation of the MeCP2 gene encoding the transcriptional repressor methyl-CpG-binding protein 2 related to the Xq28 locus. Although many different mutations of this protein are being studied in humans and in mice, the molecular pathogenesis of this disorder remains unclear. Electroencephalography is abnormal in the final stages of the syndrome. Neuroimaging showing brain atrophy may be required for differential diagnosis that includes neurodegenerative and metabolic disorders. Neuropathology shows decreased brain growth and reduced size of individual neurons, with thinned dendrites in some cortical layers and abnormalities in substantia nigra (decreased neuromelanin content), suggestive of deficient synaptogenic development, probably starting before birth. Neurometabolic changes include reduced levels of dopamine, serotonin, noradrenalin, choline acetyltransferase (ChAT), nerve growth factors, endorphines, glutamate, and other amino acids and their receptor levels in brain. Current treatment includes symptomatic, anticonvulsive and physiotherapy.

  10. INTERNATIONAL REPORT: Practical realization of the definition of the metre, including recommended radiations of other optical frequency standards (2003)

    NASA Astrophysics Data System (ADS)

    Felder, R.

    2005-08-01

    In 2003, the International Committee for Weights and Measures (CIPM) recommended updated values of the frequency for certain optical frequency standards recommended for the practical realization of the definition of the metre. The text of this CIPM Recommendation and details of the updated radiations are given here. The complete updated set of recommended radiations, including frequencies, wavelengths, uncertainties and operating conditions where appropriate, is available on the BIPM website.

  11. Calculation and Updating of Reliability Parameters in Probabilistic Safety Assessment

    NASA Astrophysics Data System (ADS)

    Zubair, Muhammad; Zhang, Zhijian; Khan, Salah Ud Din

    2011-02-01

    The internal events of nuclear power plant are complex and include equipment maintenance, equipment damage etc. These events will affect the probability of the current risk level of the system as well as the reliability of the equipment parameter values so such kind of events will serve as an important basis for systematic analysis and calculation. This paper presents a method for reliability parameters calculation and their updating. The method is based on binomial likelihood function and its conjugate beta distribution. For update parameters Bayes' theorem has been selected. To implement proposed method a computer base program is designed which provide help to estimate reliability parameters.

  12. Update to Core reporting practices in structural equation modeling.

    PubMed

    Schreiber, James B

    2016-07-21

    This paper is a technical update to "Core Reporting Practices in Structural Equation Modeling."(1) As such, the content covered in this paper includes, sample size, missing data, specification and identification of models, estimation method choices, fit and residual concerns, nested, alternative, and equivalent models, and unique issues within the SEM family of techniques.

  13. Updated guidelines on digital media use by children.

    PubMed

    Licata, Joseph Isaac; Baker, Amy Elizabeth

    2017-04-01

    Given the speed at which mobile media has grown recently, the updated American Academy of Pediatrics guidelines for digital technology use by children are a welcome addition to the toolbox of pediatric healthcare providers. This article discusses the changes to the guidelines as well as other useful current research not specifically included in those guidelines.

  14. 10 CFR 603.885 - Updated program plans and budgets.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Updated program plans and budgets. 603.885 Section 603.885... program plans and budgets. In addition to reports on progress to date, a TIA may include a provision... effort and a revised budget if there is a significant change from the initial budget....

  15. A comprehensive list of cloned human DNA sequences—1991 update

    PubMed Central

    Schmidtke, Jörg; Cooper, David N.

    1992-01-01

    An updated list of DNA sequences cloned from the human genome over the past year (1991) is presented. Intended as a guide to clone availability, this list includes published reports of cDNA, genomic and synthetic probes comprising both gene and pseudogene sequences. PMID:1598240

  16. 10 CFR 603.885 - Updated program plans and budgets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Updated program plans and budgets. 603.885 Section 603.885... program plans and budgets. In addition to reports on progress to date, a TIA may include a provision... effort and a revised budget if there is a significant change from the initial budget....

  17. 1999 Leak Detection and Monitoring and Mitigation Strategy Update

    SciTech Connect

    OHL, P.C.

    1999-09-23

    This document is a complete revision of WHC-SD-WM-ES-378, Rev 1. This update includes recent developments in Leak Detection, Leak Monitoring, and Leak Mitigation technologies, as well as, recent developments in single-shell tank retrieval technologies. In addition, a single-shell tank retrieval release protection strategy is presented.

  18. Purposes, Principles, and Standards for School Art Programs. Updated 2014

    ERIC Educational Resources Information Center

    National Art Education Association, 2014

    2014-01-01

    Fully updated to reflect current issues in the field of art education. Checklists embedded in charts allow users to indicate where their school or district stands in relation to the criteria--which has been expanded to include district wide, elementary, middle, high school, and superior standards. The criteria within the checklists reflect…

  19. School Officials and the Courts: Update 2000. ERS Monograph.

    ERIC Educational Resources Information Center

    Thompson, David P.; Hartmeister, Fredric J.

    This is the 21st in a series of yearly updates of judicial decision summaries for case law related to elementary and secondary education issues. One can use previous and future editions to track decisions on appeal or to see trends in case law. The cases included, with a few exceptions, were selected from court decisions found in federal and…

  20. Updated management of chronic kidney disease in patients with diabetes.

    PubMed

    Hass, Virginia McCoy

    2014-06-01

    Chronic diseases, including chronic kidney disease (CKD), are the primary threat to global public health in the 21st century. Recently updated guidelines from the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative provide patient care benchmarks that physician assistants can use when caring for patients with diabetes and CKD and developing clinical performance improvement plans.

  1. United States Department of Education Update, December 2006

    ERIC Educational Resources Information Center

    Linton, John

    2006-01-01

    This update reports on the activities of the Office of Vocational and Adult Education (OVAE), which includes the implementation of the new Perkins Vocational Education Act passed by the 109th Congress and signed by President Bush on August 12, 2006. There is also significant activity in preparation for the scheduled reauthorization of the Adult…

  2. Left-right-symmetric model parameters: Updated bounds

    SciTech Connect

    Polak, J.; Zralek, M. )

    1992-11-01

    Using the available updated experimental data, including the last results from the CERN {ital e}{sup +}{ital e{minus}} collider LEP and improved parity-violation results, we find new constraints on the parameters in the left-right-symmetric model in the case of light right-handed neutrinos.

  3. Legislative Update, June 2011. Report 11-06

    ERIC Educational Resources Information Center

    Blair, Julia

    2011-01-01

    This report updates the status of bills that the California Postsecondary Education Commission (CPEC) is tracking. It has positions as adopted by the Commission at its June 14, 2011 and earlier meetings. A matrix of bills tracked by CPEC staff is included.

  4. Legislative Update, December 2010. Report 10-21

    ERIC Educational Resources Information Center

    Blair, Julia

    2010-01-01

    This update contains the Governor's action on legislative initiatives being tracked by CPEC (California Postsecondary Education Commission) staff in the 2009-10 legislative session and information on the new members of the Legislature. A summary matrix of bills monitored by CPEC staff is included.

  5. Political Education: National Policy Comes of Age. The Updated Edition

    ERIC Educational Resources Information Center

    Cross, Christopher T.

    2010-01-01

    Political insider Christopher Cross has updated his critically acclaimed book to reflect recent education policy developments, including the impact of the Obama administration and "Race to the Top" as well as the controversy over NCLB's reauthorization. Featuring a new introduction and the addition of postscripts for key chapters, this…

  6. ANTA Training Update Seminar Proceedings (Brisbane, Australia, July 10, 1997).

    ERIC Educational Resources Information Center

    Australian National Training Authority, Brisbane.

    This document contains the papers and questions submitted at the Australian National Training Authority's 1997 training update seminar, which focused on vocational education and training in schools and in technical and further education (TAFE) institutions across Australia. The following papers are included: "Welcome and Comments"…

  7. Continuous flow measurements using ultrasonic velocity meters - an update

    USGS Publications Warehouse

    Oltmann, Rick

    1995-01-01

    An article in the summer 1993 Newsletter described USGS work to continously monitor tidal flows in the delta using ultrasonic velocity meters.  This article updates progress since 1993, including new installations, results of data analysis, damage during this year's high flows, and the status of each site.

  8. Documentation of structures branch programs and program updates. Project 3200

    NASA Technical Reports Server (NTRS)

    Probe, D. G.

    1975-01-01

    Update programming of applications programs for the integrated structural analysis system is reported. An attempt is made to layout a standard document format for the preparation of program documents. Documentation which involves changes, additions, and I/O capability revisions to existing programs includes a checklist which should be reviewed each time a programming effort is documented.

  9. Highlights of the University of Toronto Urology Update 2014

    PubMed Central

    Herschorn, Sender

    2015-01-01

    At the University of Toronto Urology Update 2014, a faculty of Canadian and American experts presented a series of lectures covering a range of topics in the field of urology. Areas of focus included prostate cancer (PCa), functional urology, erectile dysfunction (ED), and surgical topics (e.g., percutaneous nephrolithotomy [PCNL]). PMID:25784963

  10. An Update on the "Cycle of Violence." Research in Brief.

    ERIC Educational Resources Information Center

    Widom, Cathy S.; Maxfield, Michael G.

    This brief updates a longitudinal study comparing the arrest records of abused and neglected children with arrest records of non-abused or neglected children. Subjects included 908 substantiated cases of childhood abuse or neglect processed by the courts from 1967-71 who were matched by sex, age, race, and family socioeconomic status with 667…

  11. UPDATE OF EPA'S EMISSION FACTORS FOR LANDFILL GAS EMISSIONS

    EPA Science Inventory

    The paper describes an effort to collect updated data and determine if changes are needed to AP-42, a document that provides emission factors characterizing landfill gas (LFG) emissions from sites with and without LFG controls. The work underway includes the types of measurement ...

  12. Updating National Topographic Data Base Using Change Detection Methods

    NASA Astrophysics Data System (ADS)

    Keinan, E.; Felus, Y. A.; Tal, Y.; Zilberstien, O.; Elihai, Y.

    2016-06-01

    The traditional method for updating a topographic database on a national scale is a complex process that requires human resources, time and the development of specialized procedures. In many National Mapping and Cadaster Agencies (NMCA), the updating cycle takes a few years. Today, the reality is dynamic and the changes occur every day, therefore, the users expect that the existing database will portray the current reality. Global mapping projects which are based on community volunteers, such as OSM, update their database every day based on crowdsourcing. In order to fulfil user's requirements for rapid updating, a new methodology that maps major interest areas while preserving associated decoding information, should be developed. Until recently, automated processes did not yield satisfactory results, and a typically process included comparing images from different periods. The success rates in identifying the objects were low, and most were accompanied by a high percentage of false alarms. As a result, the automatic process required significant editorial work that made it uneconomical. In the recent years, the development of technologies in mapping, advancement in image processing algorithms and computer vision, together with the development of digital aerial cameras with NIR band and Very High Resolution satellites, allow the implementation of a cost effective automated process. The automatic process is based on high-resolution Digital Surface Model analysis, Multi Spectral (MS) classification, MS segmentation, object analysis and shape forming algorithms. This article reviews the results of a novel change detection methodology as a first step for updating NTDB in the Survey of Israel.

  13. An update on the role of medical treatment including antioxidant therapy in varicocele

    PubMed Central

    Garg, Harshit; Kumar, Rajeev

    2016-01-01

    Varicocele-associated male infertility has classically been managed using surgery or assisted reproductive techniques. With increasing evidence of oxidative stress as a pathophysiological factor in varicocele-associated infertility, medical therapy especially antioxidants might become a treatment option with lower risks. We reviewed the existing literature on the role of various medical agents in the management of male infertility attributed to varicoceles. Medical therapy is typically evaluated in three different situations such as (a) comparison of two drugs or one drug with placebo, (b) comparison of drugs versus surgery, and (c) comparison of drugs as adjuvant therapy with surgery versus drug therapy alone. Due to heterogeneity of data and lack of well-conducted studies, there is insufficient data to recommend routine use of medical therapy for men with varicocele-associated infertility and surgery remains the treatment of choice. Pregnancy and live birth rates are usually not reported in most studies and mere improvement in sperm parameters or antioxidant capacity is insufficient to support its routine use. Antioxidant therapy is a potential option due to its theoretical benefit, data from preclinical studies, and lack of major side effects. Adjuvant therapy with antioxidants after surgical repair of varicocele may improve the outcome and is a potential area for further research. PMID:26763549

  14. 75 FR 3617 - Outer Continental Shelf Air Regulations Update To Include New Jersey State Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ..., Reporting and recordkeeping requirements, Sulfur oxides. Dated: December 30, 2009. Judith A. Enck, Regional.... Variances N.J.A.C. 7:27-6.7. Exceptions Chapter 27 Subchapter 7--Sulfur (Effective 3/1/67) N.J.A.C. 7:27-7.1. Definitions N.J.A.C. 7:27-7.2. Control and prohibition of air pollution from sulfur compounds Chapter...

  15. Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations

    PubMed Central

    Chassaing, N; Martin, L; Calvas, P; Le Bert, M; Hovnanian, A

    2005-01-01

    Pseudoxanthoma elasticum (PXE) is an inherited systemic disease of connective tissue primarily affecting the skin, retina, and cardiovascular system. It is characterised pathologically by elastic fibre mineralisation and fragmentation (so called "elastorrhexia"), and clinically by high heterogeneity in age of onset and the extent and severity of organ system involvement. PXE was recently associated with mutations in the ABCC6 (ATP binding cassette subtype C number 6) gene. At least one ABCC6 mutation is found in about 80% of patients. These mutations are identifiable in most of the 31 ABCC6 exons and consist of missense, nonsense, frameshift mutations, or large deletions. No correlation between the nature or location of the mutations and phenotype severity has yet been established. Recent findings support exclusive recessive inheritance. The proposed prevalence of PXE is 1/25 000, but this is probably an underestimate. ABCC6 encodes the protein ABCC6 (also known as MRP6), a member of the large ATP dependent transmembrane transporter family that is expressed predominantly in the liver and kidneys, and only to a lesser extent in tissues affected by PXE. The physiological substrates of ABCC6 remain to be determined, but the current hypothesis is that PXE should be considered to be a metabolic disease with undetermined circulating molecules interacting with the synthesis, turnover, or maintenance of elastic fibres. PMID:15894595

  16. Insightful Imagery is Related to Working Memory Updating

    PubMed Central

    Nęcka, Edward; Żak, Piotr; Gruszka, Aleksandra

    2016-01-01

    Available body of evidence concerning the relationship between insight problem solving and working memory (WM) is ambiguous. Several authors propose that restructuring of the problem representation requires controlled search processes, which needs planning and involvement of WM. Other researchers suggest that the restructuring is achieved through the automatic spread of activation in long-term memory, assigning a limited role to WM capacity. In the present study we examined the correlations between insight problem solving performance and measures of WM updating function (n-back task), including general intelligence (as measured by Raven’s Advanced Progressive Matrices). The results revealed that updating function shared up to 30% of variance with the insight problem task performance, even when the influence of general mental ability was controlled for. These results suggest that insight problem solving is constrained by individual ability to update the content of WM. PMID:26973549

  17. Salmonella methodology update.

    PubMed

    Cox, N A

    1988-06-01

    This paper reviews the numerous research studies carried out at Richard Russell Agricultural Research Center over the past 10 to 15 yr that ultimately led to the Center's present methods for the isolation of Salmonella from processed broiler carcasses and poultry feed. In addition, the newer technologies that have recently evolved are discussed in complete detail. Included in these discussions are the advantages and disadvantages of the various technologies along with recommendations for making them more useful to the practicing food or poultry microbiologist.

  18. 2016 New Drug Update.

    PubMed

    Hussar, Daniel A

    2016-04-01

    Six new drugs marketed within the last year, which are used for medical problems often experienced by the elderly, have been selected for consideration in this review. The uses and most important properties of these agents are discussed, and a rating for each new drug is determined using the New Drug Comparison Rating (NDCR) system developed by the author. Advantages, disadvantages, and other important information regarding the new drug are identified and used as the basis for determining the rating. The drugs include a hypnotic, an anticoagulant, two drugs for heart failure, and two drugs to reduce low-density lipoprotein cholesterol.

  19. 2015 new drug update.

    PubMed

    Hussar, Daniel A

    2015-04-01

    Six new drugs approved within the last two years, which are used for medical problems often experienced by the elderly, have been selected for consideration in this review. The uses and most important properties of these agents are discussed, and a rating for each new drug is determined using the New Drug Comparison Rating system developed by the author. Advantages, disadvantages, and other important information regarding the new drug are identified and used as the basis for determining the rating. The drugs include two antidiabetic agents, one bronchodilator, one antidepressant, one for erectile dysfunction, and one for menopause-associated conditions.

  20. Acute ischemic stroke update.

    PubMed

    Baldwin, Kathleen; Orr, Sean; Briand, Mary; Piazza, Carolyn; Veydt, Annita; McCoy, Stacey

    2010-05-01

    Stroke is the third most common cause of death in the United States and is the number one cause of long-term disability. Legislative mandates, largely the result of the American Heart Association, American Stroke Association, and Brain Attack Coalition working cooperatively, have resulted in nationwide standardization of care for patients who experience a stroke. Transport to a skilled facility that can provide optimal care, including immediate treatment to halt or reverse the damage caused by stroke, must occur swiftly. Admission to a certified stroke center is recommended for improving outcomes. Most strokes are ischemic in nature. Acute ischemic stroke is a heterogeneous group of vascular diseases, which makes targeted treatment challenging. To provide a thorough review of the literature since the 2007 acute ischemic stroke guidelines were developed, we performed a search of the MEDLINE database (January 1, 2004-July 1, 2009) for relevant English-language studies. Results (through July 1, 2009) from clinical trials included in the Internet Stroke Center registry were also accessed. Results from several pivotal studies have contributed to our knowledge of stroke. Additional data support the efficacy and safety of intravenous alteplase, the standard of care for acute ischemic stroke since 1995. Due to these study results, the American Stroke Association changed its recommendation to extend the time window for administration of intravenous alteplase from within 3 hours to 4.5 hours of symptom onset; this recommendation enables many more patients to receive the drug. Other findings included clinically useful biomarkers, the role of inflammation and infection, an expanded role for placement of intracranial stents, a reduced role for urgent carotid endarterectomy, alternative treatments for large-vessel disease, identification of nontraditional risk factors, including risk factors for women, and newly published pediatric stroke guidelines. In addition, new devices for

  1. Epidemiology of urolithiasis: an update

    PubMed Central

    Trinchieri, Alberto

    2008-01-01

    Background & Aim. Changing socio-economic conditions generated changes in the prevalence, incidence and distribution for age, sex and type of urolithiasis in terms of both the site and the chemical-physical composition of the calculi. In the latter part of the 20th century the prevalence of upper urinary tract stones was increasing in Western countries whereas endemic infantile bladder stone disease was fairly widespread in huge areas of developing countries. The aim of this paper was to update previous epidemiological reports of urolithiasis by reviewing the more recent literature. Methods. Citations were extracted using PubMed database from January 2003 through December 2007 on the basis of the key words epidemiology AND urinary calculi. Results. An increase in the prevalence and incidence of urolithiasis was described in Germany whereas data from the United States were contradictory with stone disease rates increased only for women with a change of male-to-female ratio. Prevalence figures of stone disease observed in some developing country in tropical regions were similar to rates of Western countries with incidence of renal colic particularly high in warm months. African Americans had a reduced risk of stone disease compared to other racial groups but in renal stone patients all racial groups demonstrated a similarity in the incidence of underlying metabolic abnormalities. Upper urinary tract stones in children were associated more frequently with metabolic disturbances rather than with urinary tract anomalies and infection. Endemic childhood bladder stones are still present in some developing countries. Dietary risk factors for stone disease were shown different by age and sex. In particular in younger women dietary calcium, phytate and fluid intake were associated with a reduced risk of stone formation whereas animal protein and sucrose increased the risk of stone incidence. In older adults there was no association between dietary calcium and stone formation

  2. Update on chronic viral hepatitis

    PubMed Central

    Walsh, K; Alexander, G

    2001-01-01

    Many recent and significant advances in the field of chronic viral hepatitis, including therapy, suggest that an update on chronic hepatitis is timely.
Chronic hepatitis B virus infection remains a significant worldwide cause of liver cirrhosis and hepatocellular carcinoma, despite the wide availability of a long established and effective vaccine. Transmission occurs via perinatal, sexual, and parenteral routes (particularly intravenous drug abuse and although blood products still carry a risk, this is now extremely low in Western countries). Only a minority of infected adult cases develop chronic hepatitis but in children under 1 year, 90% develop chronic hepatitis. The clinical spectrum of chronic liver injury ranges from mild inflammation to end stage liver cirrhosis. Interferon alfa has been the mainstay of treatment for patients with active disease but nucleoside analogues (lamivudine and adefovir) are now available with similar efficacy. Patients with end stage liver disease and hepatocellular carcinoma can be offered transplantation but infection in the graft is commonplace. The combination of hepatitis B immunoglobulin and newer antiviral drugs reduce the incidence and severity of graft infection significantly.
The hepatitis C virus epidemic of the latter half of the 20th century now affects more than 1% of populations worldwide. This RNA virus is spread parenterally and is becoming the leading indication for liver transplantation. The majority of patients develop chronic hepatitis, which may be progressive, evolving to significant liver disease (cirrhosis or hepatocellular carcinoma) in about 20% cases after decades. Treatment with the combination of interferon alfa and ribavirin is successful in up to 40% cases. Liver transplantation is a therapeutic option for some but graft infection is universal and often complicated by progressive liver fibrosis. A vaccine remains a remote prospect so that prevention is crucial.
Hepatitis D virus infection

  3. Updated NGNP Fuel Acquisition Strategy

    SciTech Connect

    David Petti; Tim Abram; Richard Hobbins; Jim Kendall

    2010-12-01

    A Next Generation Nuclear Plant (NGNP) fuel acquisition strategy was first established in 2007. In that report, a detailed technical assessment of potential fuel vendors for the first core of NGNP was conducted by an independent group of international experts based on input from the three major reactor vendor teams. Part of the assessment included an evaluation of the credibility of each option, along with a cost and schedule to implement each strategy compared with the schedule and throughput needs of the NGNP project. While credible options were identified based on the conditions in place at the time, many changes in the assumptions underlying the strategy and in externalities that have occurred in the interim requiring that the options be re-evaluated. This document presents an update to that strategy based on current capabilities for fuel fabrication as well as fuel performance and qualification testing worldwide. In light of the recent Pebble Bed Modular Reactor (PBMR) project closure, the Advanced Gas Reactor (AGR) fuel development and qualification program needs to support both pebble and prismatic options under the NGNP project. A number of assumptions were established that formed a context for the evaluation. Of these, the most important are: • Based on logistics associated with the on-going engineering design activities, vendor teams would start preliminary design in October 2012 and complete in May 2014. A decision on reactor type will be made following preliminary design, with the decision process assumed to be completed in January 2015. Thus, no fuel decision (pebble or prismatic) will be made in the near term. • Activities necessary for both pebble and prismatic fuel qualification will be conducted in parallel until a fuel form selection is made. As such, process development, fuel fabrication, irradiation, and testing for pebble and prismatic options should not negatively influence each other during the period prior to a decision on reactor type

  4. Update on childhood brucellosis.

    PubMed

    Roushan, Mohammad R H; Amiri, Mohammad J S

    2013-04-01

    In endemic regions of brucellosis, childhood brucellosis includes up to one-third of all cases of human brucellosis. The main source of infection in children is consumption of unpasteurized dairy products and traditional local foods containing dairy products. The older boys are more involved in animal care. Boys are more commonly infected than girls. Common symptoms and signs include fever, arthralgia, sweating, peripheral arthritis and splenomegaly. Peripheral arthritis especially monoarthritis is more common and the most commonly affected joints are hip and knee. All organs may involve during the course of the disease. Isolation of Brucella spp. from the blood, bone marrow or other tissue fluids is the hallmark of diagnosis. Serologic tests are the main tools of diagnosis of brucellosis in endemic regions. Standard agglutination test (SAT) with titers > 1:160 and the 2-mercaptoethanol (2ME) test ≥ 1:80 are suggestive of active infection. Children older than 8 years should be treated with doxycycline for 45 days or 8 weeks plus gentamicin for 7 or 5 days respectively or doxycycline for 45 days and streptomycin for 14 days. Also doxycycline plus rifampin or cotrimoxazole plus rifampin for 45 days may be alternative regimens. Cotrimoxazole plus rifampin for six weeks is the regimen of choice for the treatment of patients younger than 8 years old. Gentamicin for 5 days plus cotrimoxazole for six weeks may be a suitable alternative regimen. The article presented few of the patents associated with Brucellosis.

  5. Update on Pediatric Overuse.

    PubMed

    Coon, Eric R; Young, Paul C; Quinonez, Ricardo A; Morgan, Daniel J; Dhruva, Sanket S; Schroeder, Alan R

    2017-02-01

    As concerns over health care-related harms and costs continue to mount, efforts to identify and combat medical overuse are needed. Although much of the recent attention has focused on health care for adults, children are also harmed by overuse. Using a structured PubMed search and manual tables of contents review, we identified important articles on pediatric overuse published in 2015. These articles were evaluated according to the quality of the methods, the magnitude of clinical effect, and the number of patients potentially affected and were categorized into overdiagnosis, overtreatment, and overutilization. Overdiagnosis: Findings included evidence for overdiagnosis of hypoxemia in children with bronchiolitis and skull fractures in children suffering minor head injuries. Overtreatment: Findings included evidence that up to 85% of hospitalized children with radiographic pneumonia may not have a bacterial etiology; many children are receiving prolonged intravenous antibiotic therapy for osteomyelitis although oral therapy is equally effective; antidepressant medication for adolescents and nebulized hypertonic saline for bronchiolitis appear to be ineffective; and thresholds for treatment of hyperbilirubinemia may be too low. Overutilization: Findings suggested that the frequency of head circumference screening could be relaxed; large reductions in abdominal computed tomography testing for appendicitis appear to have been safe and effective; and overreliance on C-reactive protein levels in neonatal early onset sepsis appears to extend hospital length-of-stay.

  6. Heidrun concrete TLP: Update

    SciTech Connect

    Munkejord, T.

    1995-10-01

    This paper gives a summary of the Heidrun substructure including tethers and foundations. The focus will although be on the concrete substructure. The Heidrun Field is located in 345 m water depth in the northern part of the Haltenbanken area, approximately 100N miles from the west coast of mid-Norway. The field is developed by means of a concrete Tension Leg Platform (TLP) by Conoco Norway Inc. The TLP will be moored by 16 steel tethers, arranged in groups of four per corner, which secure the substructure (hull) to the concrete foundations. A general view of the TLP is shown. The Heidrun TLP will be the northern most located platform in the North Sea when installed at Haltenbanken in 1995. Norwegian Contractors a.s (NC) is undertaking the Engineering, Procurement, Construction and Installation (EPCI) contract for the Heidrun TLP substructure. This comprises the complete delivery of the hull with two module support beams (MSB), including all mechanical outfitting. Furthermore, NC will perform all marine operations related to the substructure. For the concrete foundations NC has performed the detailed engineering work and has been responsible for the two to field and installation of the foundations.

  7. XLMR genes: Update 1996

    SciTech Connect

    Lubs, H.A.; Tranebjaerg, L.; Arena, J.F.

    1996-07-12

    A current list of all known forms of X-linked mental retardation (XLMR) and a slightly revised classification are presented. The number of known disorders has not increased because 6 disorders have been combined based on new molecular data or on clinical grounds and only 6 newly described XLMR disorders have been reported. Of the current 105 XLMR disorders, 34 have been mapped, and 18 disorders and 1 non-specific XLMR (FRAXE) have been cloned. The number of families with nonspecific XLMR with a LOD score of {ge}2.0 has more than doubled, with 42 (including FRAXE) now being known. A summary of the localization of presumed nonspecific mental retardation (MR) genes from well-studied X-chromosomal translocations and deletions is also included. Only 10-12 nonoverlapping loci are required to explain all localizations of non-specific MR from both approaches. These new trends mark the beginning of a significantly improved understanding of the role of genes on the X chromosome in producing MR. Continued close collaboration between clinical and molecular investigators will be required to complete the process. 105 refs., 2 figs., 6 tabs.

  8. Literature searches on Ayurveda: An update

    PubMed Central

    Aggithaya, Madhur G.; Narahari, Saravu R.

    2015-01-01

    Introduction: The journals that publish on Ayurveda are increasingly indexed by popular medical databases in recent years. However, many Eastern journals are not indexed biomedical journal databases such as PubMed. Literature searches for Ayurveda continue to be challenging due to the nonavailability of active, unbiased dedicated databases for Ayurvedic literature. In 2010, authors identified 46 databases that can be used for systematic search of Ayurvedic papers and theses. This update reviewed our previous recommendation and identified current and relevant databases. Aims: To update on Ayurveda literature search and strategy to retrieve maximum publications. Methods: Author used psoriasis as an example to search previously listed databases and identify new. The population, intervention, control, and outcome table included keywords related to psoriasis and Ayurvedic terminologies for skin diseases. Current citation update status, search results, and search options of previous databases were assessed. Eight search strategies were developed. Hundred and five journals, both biomedical and Ayurveda, which publish on Ayurveda, were identified. Variability in databases was explored to identify bias in journal citation. Results: Five among 46 databases are now relevant – AYUSH research portal, Annotated Bibliography of Indian Medicine, Digital Helpline for Ayurveda Research Articles (DHARA), PubMed, and Directory of Open Access Journals. Search options in these databases are not uniform, and only PubMed allows complex search strategy. “The Researches in Ayurveda” and “Ayurvedic Research Database” (ARD) are important grey resources for hand searching. About 44/105 (41.5%) journals publishing Ayurvedic studies are not indexed in any database. Only 11/105 (10.4%) exclusive Ayurveda journals are indexed in PubMed. Conclusion: AYUSH research portal and DHARA are two major portals after 2010. It is mandatory to search PubMed and four other databases because all five

  9. JPSS CGS Tools For Rapid Algorithm Updates

    NASA Astrophysics Data System (ADS)

    Smith, D. C.; Grant, K. D.

    2011-12-01

    The National Oceanic and Atmospheric Administration (NOAA) and National Aeronautics and Space Administration (NASA) are jointly acquiring the next-generation civilian weather and environmental satellite system: the Joint Polar Satellite System (JPSS). JPSS will contribute the afternoon orbit component and ground processing system of the restructured National Polar-orbiting Operational Environmental Satellite System (NPOESS). As such, JPSS replaces the current Polar-orbiting Operational Environmental Satellites (POES) managed by NOAA and the ground processing component of both POES and the Defense Meteorological Satellite Program (DMSP) replacement known as the Defense Weather Satellite System (DWSS), managed by the Department of Defense (DoD). The JPSS satellites will carry a suite of sensors designed to collect meteorological, oceanographic, climatological, and solar-geophysical observations of the earth, atmosphere, and space. The ground processing system for JPSS is known as the JPSS Common Ground System (JPSS CGS), and consists of a Command, Control, and Communications Segment (C3S) and the Interface Data Processing Segment (IDPS). Both are developed by Raytheon Intelligence and Information Systems (IIS). The Interface Data Processing Segment will process NPOESS Preparatory Project, Joint Polar Satellite System and Defense Weather Satellite System satellite data to provide environmental data products to NOAA and DoD processing centers operated by the United States government. Under NPOESS, Northrop Grumman Aerospace Systems Algorithms and Data Products (A&DP) organization was responsible for the algorithms that produce the EDRs, including their quality aspects. For JPSS, that responsibility has transferred to NOAA's Center for Satellite Applications & Research (STAR). As the Calibration and Validation (Cal/Val) activities move forward following both the NPP launch and subsequent JPSS and DWSS launches, rapid algorithm updates may be required. Raytheon and

  10. Update on management of midgut neuroendocrine tumors

    PubMed Central

    Mehrvarz Sarshekeh, Amir; Halperin, Daniel M; Dasari, Arvind

    2016-01-01

    Midgut neuroendocrine tumors are typically indolent but can be fatal when advanced. They can also cause significant morbidity due to the characteristic carcinoid syndrome. Somatostatin analogs continue to be the mainstay of treatment given their antiproliferative properties, as well as inhibitory effects on hormones that cause carcinoid syndrome. There have been several recent advances in the systemic therapy of these tumors including consolidation of somatostatin analogs as the cornerstone of therapy, completion of pivotal trials with mTOR inhibitors, and the establishment of novel approaches including peptide receptor radionuclide therapy and oral inhibitors of peripheral tryptophan hydroxylase in tumor and symptom control, respectively. In this review article, the recent advances are summarized and an updated approach to management is proposed. PMID:27347369

  11. INHERITED NEUROPATHIES: CLINICAL OVERVIEW AND UPDATE

    PubMed Central

    KLEIN, CHRISTOPHER J.; DUAN, XIAOHUI; SHY, MICHAEL E.

    2014-01-01

    Inherited neuropathy is a group of common neurologic disorders with heterogeneous clinical presentations and genetic causes. Detailed neuromuscular evaluations, including nerve conduction studies, laboratory testing, and histopathologic examination, can assist in identification of the inherited component beyond family history. Genetic testing increasingly enables definitive diagnosis of specific inherited neuropathies. Diagnosis, however, is often complex, and neurologic disability may have both genetic and acquired components in individual patients. The decision of which genetic test to order or whether to order genetic tests is often complicated, and the strategies to maximize the value of testing are evolving. Apart from rare inherited metabolic neuropathies, treatment approaches remain largely supportive. We provide a clinical update of the various types of inherited neuropathies, their differential diagnoses, and distinguishing clinical features (where available). A framework is provided for clinical evaluations, including the inheritance assessment, electrophysiologic examinations, and specific genetic tests. PMID:23801417

  12. Update on treatments for head lice.

    PubMed

    2009-05-01

    Head lice infestation is common, and mainly affects children of primary school age. Treatments include conventional chemical insecticides; fine tooth louse combs; and fluid preparations that work by a physical rather than chemical mode of action. However, each of these fails to eradicate head lice in some patients. Other disadvantages include the long contact time required for certain preparations e.g. 8 hours and the time commitment for combing regimens. Isopropyl myristate 50% in cyclomethicone solution (Full Marks Solution - SSL International) is a new fluid treatment with a physical mode of action that uses a 10-minute contact time. Here, we consider this product in the context of updating advice we gave in 2007 on treatments for head lice.

  13. Update on epigenetics in allergic disease.

    PubMed

    Harb, Hani; Renz, Harald

    2015-01-01

    Chronic inflammatory diseases, including allergies and asthma, are the result of complex gene-environment interactions. One of the most challenging questions in this regard relates to the biochemical mechanism of how exogenous environmental trigger factors modulate and modify gene expression, subsequently leading to the development of chronic inflammatory conditions. Epigenetics comprises the umbrella of biochemical reactions and mechanisms, such as DNA methylation and chromatin modifications on histones and other structures. Recently, several lifestyle and environmental factors have been investigated in terms of such biochemical interactions with the gene expression-regulating machinery: allergens; microbes and microbial compounds; dietary factors, including vitamin B12, folic acid, and fish oil; obesity; and stress. This article aims to update recent developments in this context with an emphasis on allergy and asthma research.

  14. Chitinases: An update

    PubMed Central

    Hamid, Rifat; Khan, Minhaj A.; Ahmad, Mahboob; Ahmad, Malik Mobeen; Abdin, Malik Zainul; Musarrat, Javed; Javed, Saleem

    2013-01-01

    Chitin, the second most abundant polysaccharide in nature after cellulose, is found in the exoskeleton of insects, fungi, yeast, and algae, and in the internal structures of other vertebrates. Chitinases are enzymes that degrade chitin. Chitinases contribute to the generation of carbon and nitrogen in the ecosystem. Chitin and chitinolytic enzymes are gaining importance for their biotechnological applications, especially the chitinases exploited in agriculture fields to control pathogens. Chitinases have a use in human health care, especially in human diseases like asthma. Chitinases have wide-ranging applications including the preparation of pharmaceutically important chitooligosaccharides and N-acetyl D glucosamine, preparation of single-cell protein, isolation of protoplasts from fungi and yeast, control of pathogenic fungi, treatment of chitinous waste, mosquito control and morphogenesis, etc. In this review, the various types of chitinases and the chitinases found in different organisms such as bacteria, plants, fungi, and mammals are discussed. PMID:23559820

  15. Pregnancy & perinatal transmission update.

    PubMed

    Denison, R

    1998-09-01

    According to a June 1998 report from UNAIDS, the majority of children infected with HIV acquired it from their mothers during or near birth. One way to prevent perinatal transmission of HIV is to increase prevention efforts for women. Other ways to prevent perinatal transmission include using AZT treatment, avoiding breastfeeding, and choosing a C-section delivery instead of a vaginal delivery. One important study, called the Thai study, promoted a shorter course of AZT therapy that was less expensive, more accessible, and still prevented transmission in many cases. Several reasons are cited for why some women continue breastfeeding, despite the increased risk of transmitting HIV to their babies. An important factor in preventing perinatal transmission is the overall health of the mother, and her ability to maintain her health and treatment regimen while caring for a newborn.

  16. LM6000 update program

    SciTech Connect

    Westerkamp, D.F.

    1995-12-31

    In October 1992, the first LM6000 industrial gas turbine entered commercial service. Two years later, a new dry low emission combustion system went into operation in Ghent, Belgium, followed shortly by the two units at Orange Cogen in Bartow, Florida. Additional planned modifications to achieve even lower emission levels and further improve the thermodynamic performance of this equipment are planned for late 1997. This paper presents the current status of the LM6000 program, including reliability and availability trends, and describes the product development program GE is currently implementing on the LM6000. The design changes required to increase the output and efficiency, as well as improve emissions capability, are discussed in some detail. The impact that these improvements have on project economics is also reviewed.

  17. Mono County update

    SciTech Connect

    Lyster, D. )

    1988-12-01

    The Mono County Board of Supervisors approved the issuance of a use-permit for the Mammoth-Pacific II geothermal power plant. The power plant will be a binary, air-cooled, 10-megawatt, net, project. An appeal was filed by the California Department of Fish and Game, and the permit will not take effect until this appeal is resolved. Mono County also issued a project use-permit to proposers of Bonneville Pacific Corporations Mammoth Chance Geothermal Project, also a 10-megawatt, net, binary and air-cooled project. The permit was appealed by the Sierra Club, Cal-Trout, and the California Department of Fish and Game. Now, a subsequent EIR must be prepared for public review and comment. The subsequent EIR will address the issue of cumulative impacts and will include a discussion of new information.

  18. Autoimmune encephalitis update

    PubMed Central

    Dalmau, Josep; Rosenfeld, Myrna R.

    2014-01-01

    Cancer-associated immune-mediated disorders of the central nervous system are a heterogeneous group. These disorders include the classic paraneoplastic neurologic disorders and the more recently described autoimmune encephalitis associated with antibodies to neuronal cell-surface or synaptic receptors that occur with and without a cancer association. Autoimmune encephalitis is increasingly recognized as the cause of a variety of neuropsychiatric syndromes that can be severe and prolonged. In contrast to the classic paraneoplastic disorders that are poorly responsive to tumor treatment and immunotherapy, autoimmune encephalitis often responds to these treatments, and patients can have full or marked recoveries. As early treatment speeds recovery, reduces disability, and decreases relapses that can occur in about 20% of cases, it is important that the immune pathogenesis of these disorders is recognized. PMID:24637228

  19. Updating the Wnt pathways

    PubMed Central

    Yu, Jia; Virshup, David M.

    2014-01-01

    In the three decades since the discovery of the Wnt1 proto-oncogene in virus-induced mouse mammary tumours, our understanding of the signalling pathways that are regulated by the Wnt proteins has progressively expanded. Wnts are involved in an complex signalling network that governs multiple biological processes and cross-talk with multiple additional signalling cascades, including the Notch, FGF (fibroblast growth factor), SHH (Sonic hedgehog), EGF (epidermal growth factor) and Hippo pathways. The Wnt signalling pathway also illustrates the link between abnormal regulation of the developmental processes and disease manifestation. Here we provide an overview of Wnt-regulated signalling cascades and highlight recent advances. We focus on new findings regarding the dedicated Wnt production and secretion pathway with potential therapeutic targets that might be beneficial for patients with Wnt-related diseases. PMID:25208913

  20. Female athlete triad update.

    PubMed

    Beals, Katherine A; Meyer, Nanna L

    2007-01-01

    The passage of Title IX legislation in 1972 provided enormous opportunities for women to reap the benefits of sports participation. For most female athletes, sports participation is a positive experience, providing improved physical fitness, enhanced self-esteem, and better physical and mental health. Nonetheless, for a few female athletes, the desire for athletic success combined with the pressure to achieve a prescribed body weight may lead to the development of a triad of medical disorders including disordered eating, menstrual dysfunction, and low bone mineral density (BMD)--known collectively as the female athlete triad. Alone or in combination, the disorders of the triad can have a negative impact on health and impair athletic performance.

  1. Carney Complex: an update

    PubMed Central

    Correa, Ricardo; Salpea, Paraskevi; Stratakis, Constantine

    2015-01-01

    Carney Complex (CNC) is a rare autosomal dominant syndrome, characterized by pigmented lesions of the skin and mucosa, cardiac, cutaneous and other myxomas, and multiple endocrine tumors. The disease is caused by inactivating mutations or large deletions of the PRKAR1A gene located at 17q22–24 coding for the regulatory subunit type I alpha of protein kinase A (PKA) gene. Most recently, components of the complex have been associated with defects of other PKA subunits, such as the catalytic subunits PRKACA (adrenal hyperplasia) and PRKACB (pigmented spots, myxomas, pituitary adenomas). In this report, we review CNC, its clinical features, diagnosis, treatment, and molecular etiology including PRKAR1A mutations and the newest on PRKACA and PRKACB defects especially as they pertain to adrenal tumors and Cushing’s syndrome. PMID:26130139

  2. Tendinopathy: Update on Pathophysiology.

    PubMed

    Scott, Alex; Backman, Ludvig J; Speed, Cathy

    2015-11-01

    Synopsis Tendinopathy has become the accepted term to describe a spectrum of changes that occur in damaged and/or diseased tendons. Over the past 2 decades, there have been new insights into tendon pathophysiology of relevance to clinicians, including (1) better characterization of the overuse injury process and the resultant structural and functional disruption in chronically painful tendons, (2) improved understanding of the pathomechanics associated with chronic tendon injury, and (3) greater knowledge about the influence of lifestyle factors and drugs on tendon pathology. The implications of these new insights are discussed. J Orthop Sports Phys Ther 2015;45(11):833-841. Epub 21 Sep 2015. doi:10.2519/jospt.2015.5884.

  3. Update on desmoid tumors.

    PubMed

    Escobar, C; Munker, R; Thomas, J O; Li, B D; Burton, G V

    2012-03-01

    Desmoid tumors (DTs) are histologically benign proliferations of stromal cells but may grow locally aggressive. Overall, DTs are rare (0.03% of all neoplasms). A minority of DTs is associated with Gardner syndrome and mutations of the familial adenomatous polyposis (FAP) gene. Most spontaneous DTs are associated with mutations of the beta-catenin gene. This mutation results in the activation of Wnt/catenin signaling. Due to their variable clinical presentation and behavior, no standard approach for DTs can be recommended. In most cases of DTs of the extremities surgical extirpation is indicated, whereas in many other cases, a multimodal and multidisciplinary concept should be followed. In this review article, we discuss the diagnosis, pathogenesis, and treatment options for DTs, including targeted therapy with tyrosine kinase inhibitors.

  4. Update on Cutaneous Calciphylaxis

    PubMed Central

    Wollina, Uwe

    2013-01-01

    Calciphylaxis is a devastating disorder with a mortality rate of 80% due to sepsis and organ failure. Hallmarks of this rare disease are arteriolar media calcification, thrombotic cutaneous ischemia, and necrotic ulcerations. Different mechanisms of vascular calcification can lead to calciphylaxis. Early diagnosis by deep cutaneous ulcer biopsy is most important for prognosis. Here, dermatologists play a significant role although treatment usually needs an interdisciplinary approach. Surgical procedures had been the cornerstone of treatment in the past including parathyroidectomy, but recently new medical treatments emerged aiming to normalize disturbances of minerals to reduce the serum concentration of sodium phosphate and to prevent precipitation and calcification. Multimodal therapy is warranted but only aggressive surgical debridement of cutaneous ulcers has shown significant outcome improvement. PMID:23716795

  5. Posterior pole tumor update.

    PubMed

    Ou, Judy I; Wheeler, Sharon M; O'Brien, Joan M

    2002-12-01

    This chapter focuses on the diagnosis and management of choroidal melanoma in light of recent findings from the COMS. Retinoblastoma is emphasized to describe recent trends in primary treatment away from EBRT and toward chemoreduction with local therapy. In addition, vascular and glial tumors of the retina and tumors of the retinal pigment epithelium are described because of the association between these lesions and systemic disease. Recent advances in treatment and genetic testing for these diseases are discussed. Finally, ocular metastasis, intraocular lymphoid tumors, and intraocular leukemia are included because of their importance in determining systemic treatment and prognosis. The chapter gives an overview of important posterior pole tumors and highlights recent developments in the management of each intraocular disease process.

  6. TMT common software update

    NASA Astrophysics Data System (ADS)

    Gillies, Kim; Brighton, Allan; Buur, Hanne

    2016-08-01

    TMT Common Software (CSW). CSW consists of software services and library code that is used by developers to create the subsystems and components that participate in the software system. CSW also defines the types of components that can be constructed and their functional roles in the software system. TMT CSW has recently passed its preliminary design review. The unique features of CSW include its use of multiple, open-source products as the basis for services, and an approach that works to reduce the amount of CSW-provided infrastructure code. Considerable prototyping was completed during this phase to mitigate risk with results that demonstrate the validity of this design approach and the selected service implementation products. This paper describes the latest design of TMT CSW, key features, and results from the prototyping effort.

  7. Renal Ablation Update

    PubMed Central

    Khiatani, Vishal; Dixon, Robert G.

    2014-01-01

    Thermal ablative technologies have evolved considerably in the recent past and are now an important component of current clinical guidelines for the treatment of small renal masses. Both radiofrequency ablation and cryoablation have intermediate-term oncologic control that rivals surgical options, with favorable complication profiles. Studies comparing cryoablation and radiofrequency ablation show no significant difference in oncologic control or complication profile between the two modalities. Early data from small series with microwave ablation have shown similar promising results. Newer technologies including irreversible electroporation and high-intensity–focused ultrasound have theoretical advantages, but will require further research before becoming a routine part of the ablation armamentarium. The purpose of this review article is to discuss the current ablative technologies available, briefly review their mechanisms of action, discuss technical aspects of each, and provide current data supporting their use. PMID:25049445

  8. Lung cancer screening update

    PubMed Central

    Dhillon, Samjot Singh; Loewen, Gregory; Jayaprakash, Vijayvel; Reid, Mary E.

    2013-01-01

    Lung cancer is the leading cause of cancer-related mortality globally and the American cancer society estimates approximately 226,160 new cases and 160,340 deaths from lung cancer in the USA in the year 2012. The majority of lung cancers are diagnosed in the later stages which impacts the overall survival. The 5-year survival rate for pathological st age IA lung cancer is 73% but drops to only 13% for stage IV. Thus, early detection through screening and prevention are the keys to reduce the global burden of lung cancer. This article discusses the current state of lung cancer screening, including the results of the National Lung Cancer Screening Trial, the consideration of implementing computed tomography screening, and a brief overview of the role of bronchoscopy in early detection and potential biomarkers that may aid in the early diagnosis of lung cancer. PMID:23599684

  9. Burning Mouth Syndrome: update.

    PubMed

    Spanemberg, Juliana Cassol; Rodríguez de Rivera Campillo, Eugenia; Salas, Enric Jané; López López, José

    2014-06-01

    Burning Mouth Syndrome (BMS) is a chronic disorder that predominately affects middle-aged women in the postmenopausal period. The condition is distinguished by burning symptoms of the oral mucosa and the absence of any clinical signs. The etiology of BMS is complex and it includes a variety of factors. Local, systemic and psychological factors such as stress, anxiety and depression are listed among the possible causes of BMS. BMS may sometimes be classified as BMS Type I, II or III. Although this syndrome is not accompanied by evident organic alterations and it does not present health risks, it can significantly reduce the patient's quality of life. This study analyzes the available literature related to BMS, and makes special reference to its therapeutic management. The pages that follow will also discuss the diagnostic criteria that should be respected, etiological factors, and clinical aspects. We used the PubMed database and searched it by using the keywords "burning mouth syndrome", "BMS and review", and "burning mouth and review", in the title or abstract of the publication. BMS treatment usually steers towards the management of the symptoms; however, the specific local factors that could play a significant role in worsening the oral burning sensation should be eradicated. The most widely accepted treatment options that show variable results include tricyclic antidepressants, benzodiazepines and antipsychotic drugs; nevertheless there are other therapies that can also be carried out. Professionals that work in the field of dentistry should formulate standardized symptomatic and diagnostic criteria in order to more easily identify the most effective and reliable strategies in BMS treatment through multidisciplinary research.

  10. Source Update Capture in Information Agents

    NASA Technical Reports Server (NTRS)

    Ashish, Naveen; Kulkarni, Deepak; Wang, Yao

    2003-01-01

    In this paper we present strategies for successfully capturing updates at Web sources. Web-based information agents provide integrated access to autonomous Web sources that can get updated. For many information agent applications we are interested in knowing when a Web source to which the application provides access, has been updated. We may also be interested in capturing all the updates at a Web source over a period of time i.e., detecting the updates and, for each update retrieving and storing the new version of data. Previous work on update and change detection by polling does not adequately address this problem. We present strategies for intelligently polling a Web source for efficiently capturing changes at the source.

  11. Prevalence of fibromyalgia: literature review update.

    PubMed

    Marques, Amelia Pasqual; Santo, Adriana de Sousa do Espírito; Berssaneti, Ana Assumpção; Matsutani, Luciana Akemi; Yuan, Susan Lee King

    2016-12-18

    The present study aimed to update the literature review on the prevalence of fibromyalgia (FM) published in 2006. A bibliographical survey was carried out from 2005 to 2014 in the MEDLINE, Web of Science, Embase, LILACS and SciELO databases and 3274 records were identified. Five researchers selected the studies, following the inclusion criteria: studies that obtained the prevalence of FM. FM studies in associated diseases were excluded. When screening by title and abstract, 2073 irrelevant articles were excluded. The full texts of 210 articles were evaluated for eligibility and this review included 39 studies, described in 41 articles. The selected studies were grouped into four categories: a) prevalence of FM in the general population; B) prevalence of FM in women; C) prevalence of FM in rural and urban areas; D) prevalence of FM in special populations. The literature shows values of FM prevalence in the general population between 0.2 and 6.6%, in women between 2.4 and 6.8%, in urban areas between 0.7 and 11.4%, in rural areas between 0.1 and 5.2%, and in special populations values between 0.6 and 15%. This literature review update shows a significant increase in FM prevalence studies in the world. The new 2010 American College of Rheumatology criteria have not been widely used yet and the COPCORD (Community-oriented program for control of Rheumatic Diseases) methodology has increased the quality of studies on the prevalence of rheumatic diseases in general.

  12. Update on pathology of ocular parasitic disease

    PubMed Central

    Das, Dipankar; Ramachandra, Varsha; Islam, Saidul; Bhattacharjee, Harsha; Biswas, Jyotirmay; Koul, Akanksha; Deka, Panna; Deka, Apurba

    2016-01-01

    Parasites are a group of eukaryotic organisms that may be free-living or form a symbiotic or parasitic relationship with the hosts. Consisting of over 800,000 recognized species, parasites may be unicellular (Protozoa) or multicellular (helminths and arthropods). The association of parasites with human population started long before the emergence of civilization. Parasitic zoonotic diseases are prevalent worldwide including India. Appropriate epidemiological data are lacking on existing zoonotic parasitic diseases, and newer diseases are emerging in our scenario. Systemic diseases such as cysticercosis, paragonimiasis, hydatidosis, and toxoplasmosis are fairly common. Acquired Toxoplasma infections are rising in immune-deficient individuals. Amongst the ocular parasitic diseases, various protozoas such as Cystoidea, trematodes, tissue flagellates, sporozoas etc. affect humans in general and eyes in particular, in different parts of the world. These zoonoses seem to be a real health related problem globally. Recent intensification of research throughout the world has led to specialization in biological fields, creating a conducive situation for researchers interested in this subject. The basics of parasitology lie in morphology, pathology, and with recent updates in molecular parasitology, the scope has extended further. The current review is to address the recent update in ophthalmic parasites with special reference to pathology and give a glimpse of further research in this field. PMID:27958200

  13. Radiometric calibration updates to the Landsat collection

    NASA Astrophysics Data System (ADS)

    Micijevic, Esad; Haque, Md. Obaidul; Mishra, Nischal

    2016-09-01

    The Landsat Project is planning to implement a new collection management strategy for Landsat products generated at the U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center. The goal of the initiative is to identify a collection of consistently geolocated and radiometrically calibrated images across the entire Landsat archive that is readily suitable for time-series analyses. In order to perform an accurate land change analysis, the data from all Landsat sensors must be on the same radiometric scale. Landsat 7 Enhanced Thematic Mapper Plus (ETM+) is calibrated to a radiance standard and all previous sensors are cross-calibrated to its radiometric scale. Landsat 8 Operational Land Imager (OLI) is calibrated to both radiance and reflectance standards independently. The Landsat 8 OLI reflectance calibration is considered to be most accurate. To improve radiometric calibration accuracy of historical data, Landsat 1-7 sensors also need to be cross-calibrated to the OLI reflectance scale. Results of that effort, as well as other calibration updates including the absolute and relative radiometric calibration and saturated pixel replacement for Landsat 8 OLI and absolute calibration for Landsat 4 and 5 Thematic Mappers (TM), will be implemented into Landsat products during the archive reprocessing campaign planned within the new collection management strategy. This paper reports on the planned radiometric calibration updates to the solar reflective bands of the new Landsat collection.

  14. A taxonomy update for the family Polyomaviridae.

    PubMed

    Calvignac-Spencer, Sébastien; Feltkamp, Mariet C W; Daugherty, Matthew D; Moens, Ugo; Ramqvist, Torbjörn; Johne, Reimar; Ehlers, Bernhard

    2016-06-01

    Many distinct polyomaviruses infecting a variety of vertebrate hosts have recently been discovered, and their complete genome sequence could often be determined. To accommodate this fast-growing diversity, the International Committee on Taxonomy of Viruses (ICTV) Polyomaviridae Study Group designed a host- and sequence-based rationale for an updated taxonomy of the family Polyomaviridae. Applying this resulted in numerous recommendations of taxonomical revisions, which were accepted by the Executive Committee of the ICTV in December 2015. New criteria for definition and creation of polyomavirus species were established that were based on the observed distance between large T antigen coding sequences. Four genera (Alpha-, Beta, Gamma- and Deltapolyomavirus) were delineated that together include 73 species. Species naming was made as systematic as possible - most species names now consist of the binomial name of the host species followed by polyomavirus and a number reflecting the order of discovery. It is hoped that this important update of the family taxonomy will serve as a stable basis for future taxonomical developments.

  15. The primordial helium abundance from updated emissivities

    SciTech Connect

    Aver, Erik; Olive, Keith A.; Skillman, Evan D.; Porter, R.L. E-mail: olive@umn.edu E-mail: skillman@astro.umn.edu

    2013-11-01

    Observations of metal-poor extragalactic H II regions allow the determination of the primordial helium abundance, Y{sub p}. The He I emissivities are the foundation of the model of the H II region's emission. Porter, Ferland, Storey, and Detisch (2012) have recently published updated He I emissivities based on improved photoionization cross-sections. We incorporate these new atomic data and update our recent Markov Chain Monte Carlo analysis of the dataset published by Izotov, Thuan, and Stasi'nska (2007). As before, cuts are made to promote quality and reliability, and only solutions which fit the data within 95% confidence level are used to determine the primordial He abundance. The previously qualifying dataset is almost entirely retained and with strong concordance between the physical parameters. Overall, an upward bias from the new emissivities leads to a decrease in Y{sub p}. In addition, we find a general trend to larger uncertainties in individual objects (due to changes in the emissivities) and an increased variance (due to additional objects included). From a regression to zero metallicity, we determine Y{sub p} = 0.2465 ± 0.0097, in good agreement with the BBN result, Y{sub p} = 0.2485 ± 0.0002, based on the Planck determination of the baryon density. In the future, a better understanding of why a large fraction of spectra are not well fit by the model will be crucial to achieving an increase in the precision of the primordial helium abundance determination.

  16. [Bariatric surgery: an update].

    PubMed

    Moreno Esteban, B; Zugasti Murillo, A

    2004-01-01

    The indication of bariatric surgery as therapeutic procedure for morbid obese patients requires the application of selection criteria which deal with the degree of obesity, associated complications and previous failure of conventional therapy. Alcohol or drug addiction and concomitant serious disease are contraindications for bariatric surgery. Before operation, a full assessment is needed to identify possible eating behaviour disturbances and associated comorbidity such as cardiovascular disease, sleep apnoea, metabolic and psychiatric alterations which might induce intra and postoperative complications. Surgical techniques can be classified as restrictive, malabsortive and mixed procedures. Gastroplasty and adjustable gastric banding are restrictive techniques, which are indicated in obese patients with body mass index less than 45 kg/m2. Mixed techniques are the most used procedures. They include gastric by-pass which causes a reduction of 60-70% of weight excess, biliopancreatic diversion and duodenal switch which can eliminate a 75% of body weight excess. Following bariatric surgery a dramatic improvement in associated comorbidity can be demonstrated, specially in what refers to diabetes, hypertension, dislipidaemia and apnoea. Postoperative mortality is around 1-2%. Peritonitis and venous thromboembolism are the most serious complications. Postoperative follow-up should be lifelong and requires a progressive nutrition planning and vitamin supplementation.

  17. Nosocomial infection update.

    PubMed Central

    Weinstein, R. A.

    1998-01-01

    Historically, staphylococci, pseudomonads, and Escherichia coli have been the nosocomial infection troika; nosocomial pneumonia, surgical wound infections, and vascular access-related bacteremia have caused the most illness and death in hospitalized patients; and intensive care units have been the epicenters of antibiotic resistance. Acquired antimicrobial resistance is the major problem, and vancomycin-resistant Staphylococcus aureus is the pathogen of greatest concern. The shift to outpatient care is leaving the most vulnerable patients in hospitals. Aging of our population and increasingly aggressive medical and surgical interventions, including implanted foreign bodies, organ transplantations, and xenotransplantation, create a cohort of particularly susceptible persons. Renovation of aging hospitals increases risk of airborne fungal and other infections. To prevent and control these emerging nosocomial infections, we need to increase national surveillance, "risk adjust" infection rates so that interhospital comparisons are valid, develop more noninvasive infection-resistant devices, and work with health-care workers on better implementation of existing control measures such as hand washing. PMID:9716961

  18. Global update: UK.

    PubMed

    Culme-Seymour, Emily J

    2012-11-01

    2012 has been an exciting year in the UK with substantial development on every front - research, clinical, industry and government. In particular, the focus has now moved to encompass far more post-research activities, with the continued enrolment of patients onto two pioneering Phase I clinical trials: ReNeuron's ReN001 stem cell therapy for stroke (PISCES) in Southern General Hospital, Greater Glasgow and Advanced Cell Technology's retinal pigment epithelial cells derived from human embryonic stem cells for Stargardts macular dystrophy and dry age-related macular degeneration at Moorfields Eye Hospital, London. The funding landscape for the sector has evolved from previous years to more fully embrace development and translation, including the provision of £180 million available for biomedical research via the Biomedical Catalyst Fund (joint Technology Strategy Board and Medical Research Council [MRC] funding) and a further £25 million through the UK Research Council's UK Regenerative Medicine Platform initiative, as well as ongoing developments with the Cell Therapy Catapult, which all act to further encourage a pan-UK collaborative environment. Overall, the UK cell therapy community continues to thrive and impact heavily upon the worldwide sector, with an established research base, a solid approach to translation and a small but growing commercial sector that is going from strength to strength.

  19. Platform for Action: update.

    PubMed

    1995-01-01

    The Center for Women's Global Leadership (CWGL) has collaborated in the preparation of amendments and strategies designed to withstand the challenges being posed to the Platform for Action of the Fourth World Conference on Women. Specific challenges include the inappropriate use of the word "universal" to modify "human rights." This implies that some human rights are less than universal. The strategy proposed is to accept the use of the word "universal" in this context only when it affirms principles of universality contained in the Vienna Programme of Action and not where its use would restrict the rights to which women are entitled. A second concern is over the use of the word "equity" rather than "equality" when referring to gender relations. The use of these terms will be carefully monitored to insure that "equity" not be used to undermine the principle of gender equality. The third concern is the efforts of some governments to hinder the integration of women's human rights throughout the UN system. Such efforts will be opposed. Fourth, the CWGL will seek the inclusion of language which recognizes the barriers that different groups of women face when trying to secure their rights. Finally, the CWGL will propose inclusion of language recognizing and protecting sexual orientation rights. The CWGL is also going to work to translate the abstract language of the Platform for Action into political organizing potential to insure that governments will follow through on their agreements.

  20. Update on ropivacaine.

    PubMed

    Wang, R D; Dangler, L A; Greengrass, R A

    2001-12-01

    Long-acting local anaesthetics are primarily used in the practice of anaesthesia, particularly in regional anaesthesia and analgesia. Ropivacaine is a new long-acting local anaesthetic that has been the focus of interest because of its increased cardiovascular safety compared with bupivacaine. Other advantages of ropivacaine over bupivacaine include a greater sensorimotor differential block and shorter elimination half-life (t(1/2)), with a lower potential for accumulation. The most important attribute of ropivacaine, however, is its increased margin of safety compared with bupivacaine when given in equal doses. Many post-marketing studies have focused on the comparisons of efficacy in blocks and toxicity profiles of bupivacaine versus ropivacaine. Recent animal toxicity studies confirm the results of original studies showing that ropivacaine has less cardiovascular toxicity than bupivacaine with respect to direct myocardial depression, success of resuscitation and arrhythmogenic potential when given in equal doses. Reduced cardiotoxicity may be a distinct characteristic of ropivacaine. A review of current literature suggests that, at clinically relevant doses, ropivacaine provides the lowest potential risk of cardiotoxicity for inadvertent intravascular injection. Studies are currently under way comparing ropivacaine with levobupivacaine, the latest addition to the group of long-acting local anaesthetics.

  1. Update in liver transplantation.

    PubMed Central

    Wong, W. W.; Bain, V. G.

    1999-01-01

    OBJECTIVE: To review recent developments in liver transplantation with particular emphasis on issues relevant to patient care before and after transplantation. QUALITY OF EVIDENCE: Preference was given to recent studies with well-designed cohort methods and large numbers of study subjects. Data on natural history are summarized from large databases in Canada and the United States. Due to the nature of the subjects involved, most treatment studies are open studies or consecutive series rather than randomized controlled trials. MAIN MESSAGE: Substantial advances in liver transplantation have established it as an effective treatment for most end-stage liver diseases, with 1-year survival rates higher than 85% in many centres. Early referral by family physicians and careful patient selection by transplant centres remain crucial to continued success. Managing these patients requires special care from family physicians because of post-transplantation immunosuppression, increased risk of opportunistic infection, and transplantation-associated medical problems. Other unresolved issues include recurrence of disease (hepatitis B and C, and malignancy) and an ongoing shortage of organs. CONCLUSIONS: Liver transplantation is an effective form of therapy for end-stage liver disease, improving both patients' likelihood of survival and their quality of life. Because medical care of liver transplant patients is so complex, coordinated efforts between primary care physicians and transplant teams are crucial. PMID:10349068

  2. Multiple Myeloma: An Update

    PubMed Central

    Al-Farsi, Khalil

    2013-01-01

    Multiple myeloma is a rare, largely incurable malignant disease of plasma cells. Patients usually present with hypercalcemia, renal insufficiency, anemia and/or lytic bony lesions along with a monoclonal protein in the serum and/or urine in addition to an increase in the number of clonal plasma cells in the bone marrow. Patients with myeloma live on an average for five to seven years, with their survival dependent on the presence or absence of different prognostic markers. Treatment of younger fit patients is with induction therapy consisting of steroids with one or more novel anti-myeloma agents followed by high dose melphalan and autologous stem cell transplantation, while older and less fit patients are treated with melphalan-based combination chemotherapy. Supportive care is of paramount importance and includes the use of bisphosphonates, prophylactic antibiotics, thrombosis prophylaxis and the use of hematopoietic growth factors along with the treatment of complications of disease and its therapy. As more progress is being made and deeper responses are being attained, the disease might turn into a potentially curable one in the near future. PMID:23386937

  3. [Coxarthrosis--an update].

    PubMed

    Imhof, H; Nöbauer-Huhmann, I; Trattnig, S

    2009-05-01

    Degenerative osteoarthritis of the hip joint (coxarthrosis) is the most common disease of the hip joint in adults. The diagnosis is based on a combination of radiographic findings and characteristic clinical symptoms. The lack of a radiographic consensus definition has seemingly resulted in a variation of the published incidences and prevalence of degenerative osteoarthritis of the hip joint. The chronological sequence of degeneration includes the following basic symptoms on conventional radiographs and CT: joint space narrowing, development of osteophytes, subchondral demineralisation/sclerosis and cyst formation, as well as loose bodies, joint malalignment and deformity. MR imaging allows additional visualization of early symptoms and/or activity signs such as cartilage edema, cartilage tears and defects, subchondral bone marrow edema, synovial edema and thickening, joint effusion and muscle atrophy.The scientific dispute concerns the significance of (minimal) joint malalignment (e.g. impingement, dysplasia etc.) and forms of malpositioning which as possible prearthrosis have a high probability of leading to degenerative osteoarthritis. Moreover, without any question, the preservation of joint containment and gender differences are important additional basic diagnostic principles, which have gained great interest in recent years.In research different MR procedures such as Na and H spectroscopy, T2*-mapping etc. with ultrahigh field MR allow cartilage metabolism and its changes in early degenerative osteoarthritis ("biochemical imaging") to be studied. There is no doubt that even in a few years new profound knowledge is to be expected in this field.

  4. Mono County update

    SciTech Connect

    Lyster, D.L.

    1987-06-01

    On February 9, 1988, the Mono County Board of Supervisors voted to approve Bonneville Pacific Corporation's Mammoth Chance Geothermal Project. The project is an air-cooled, binary, geothermal power plant, 10 megawatts, net. The Mono County Board of Supervisors issued a project use-permit with vigorous and stringent conditions. Specific emphasis was placed on the establishment of a monitoring program designed to detect the effects of geothermal development on the springs at the Hot Creek Fish Hatchery and Hot Creek Gorge. On October 5, 1987, the Mono County Planning Commission granted a use-permit to Mammoth Pacific for its Mammoth Pacific II Project, a binary, air-cooled, geothermal power plant, 10 megawatts, net. The issuance of the use-permit instigated an appeal by the Sierra Club. That appeal was heard on February 22, 1988, At the end of the testimony, the Board of Supervisors voted to uphold the appeal of the Sierra Club, thereby denying the project by a vote of 3 to 2. The main areas of concern voiced by the majority of the Board included potential hydrologic impacts to Hot Creek Gorge and Hot Creek Fish Hatchery, visual impacts, and impacts to mule deer migration and survival. One of the options now available to Mammoth Pacific is to request that the project be denied without prejudice. This would allow Mammoth Pacific to return to the Board immediately with additional material regarding its concerns.

  5. Liposuction devices: technology update

    PubMed Central

    Shridharani, Sachin M; Broyles, Justin M; Matarasso, Alan

    2014-01-01

    Since its introduction by Illouz and others over 30 years ago, suction-assisted lipectomy/liposuction/lipoplasty has evolved tremendously and has developed into one of the most popular procedures in aesthetic plastic surgery. Liposuction is an effective procedure employed to treat localized adipose deposits in patients not suffering from generalized obesity. These accumulations of subcutaneous fat often occur in predictable distributions in both men and women. A cannula connected to a suction-generating source allows for small incisions to be strategically placed and large volumes of fat to be removed. This fat removal leads to improved harmonious balance of a patient’s physique and improved body contour. Various surgical techniques are available and have evolved as technology has improved. Current technology for liposuction includes suction-assisted lipectomy, ultrasound-assisted, power-assisted, laser-assisted, and radiofrequency-assisted. The choice of technology and technique often depends on patient characteristics and surgeon preference. The objective of this review is to provide a thorough assessment of current technologies available to plastic surgeons performing liposuction. PMID:25093000

  6. The RHIC status update

    SciTech Connect

    Ozaki, S.

    1995-07-15

    The construction of the Relativistic Heavy Ion Collider (RHIC) began in 1991, with the completion date originally scheduled for 1997. Significant reduction of the funding levels in FY 1993 and 1994, and the funding level cap for FY 1995 and later years caused a 19-month stretchout of the construction period to the second quarter of FY 1999, and an increase of the total estimated cost (TEC) to $475 M. The Project, therefore, is now at the halfway mark of the construction period with actual cost and schedule performance tracking close to the DOE-approved baseline. Construction funding through FY 1994 reached close to 60% of the TEC. Incidentally, if one adds the current value of preexisting facilities which will be incorporated into RHIC, such as the injection system (Tandem Van de Graaff - the Booster - the AGS), the esixting 3.8 km tunnel, the 24 kW helium refrigerator, etc., the total value of the RHIC facility, when completed, will reach one billion dollars, if not more. The accelerator lattice design was finalized in 1992 after an intensive study was made to optimize the collider design for performance, operational flexibility, and value engineering. The civil construciton, including the collider enclosure, magnet access ports to the ring tunnel, and six service buildings for accelerator power supplies and cryogenic control boxes was completed.

  7. [An update on measles].

    PubMed

    Caseris, M; Burdet, C; Lepeule, R; Houhou, N; Yeni, P; Yazdanpanah, Y; Joly, V

    2015-05-01

    Measles is a highly contagious infectious disease, which needs more than 95% worldwide vaccination coverage of 2 doses to be eradicated. Despite an important involvement of the WHO for massive immunization, goals have not bean reached, and outbreaks can occur at any time in many countries, including Western Europe. In France, 22,000 cases were identified between 2009 and 2011, mainly in infants and young adults, which are not or not enough vaccinated (one dose). In 2012, even though the number of cases has drastically decreased, the outbreak is still going on, especially in South of France. That is why every clinician needs to be concerned about the clinical manifestations of the disease, and its complications. Besides a febrile rash, measles is often responsible of pneumonia and biologic hepatitis in adults. Hepatitis does not seem frequent in children. Clinicians need to be aware of specific complications, like encephalitis in case of cellular immunodepression, high risk of pneumonia in pregnant women. In patients previously vaccinated, incidence of complications is the same but patients are not contagious. Even if measles diagnosis is clinical, blood confirmation by serology is recommended in France when possible. Outcome is mainly favourable, but measles is not well-tolerated with high levels of hospitalisation even without any complication. Vaccination is the only way to protect against it.

  8. An update on analgesics.

    PubMed

    Power, I

    2011-07-01

    Recent introduction of new analgesics into the clinic is best described as a slow process with activity classified into two main areas: improving analgesic efficacy/potency and reducing side-effect profile. This review article describes some of the recent advances with an emphasis on use in the acute setting. In this respect, opioids continue to be the mainstay (but not the only) analgesic and there have been important improvements in their clinical effect profile. For example, tapentadol has been introduced as a mixed opioid and norepinephrine uptake inhibitor which, unlike tramadol, does not require metabolic activation and does not suffer from isomer-dependent pharmacodynamics. Opioid antagonists have received much attention recently either used alone, methylnaltrexone (s.c) or alvimopan (p.o), or in combination, Targinact (oxycodone/naloxone), and appear to be effective in reducing opioid side-effects such as those in the gastrointestinal tract. Other agents where there has been recent development include the use of gabapentin, methylxanthines, and local anaesthetics. An interesting area of translation of basic research is in the inhibition of breakdown of endogenous opioids with opiorphin, targeting of the endocannabinoid system, and the use of ampakines to obtund opioid-induced side-effects. It is clear that there is still much work to be done, but the need for highly efficacious analgesics with good side-effect profile remains.

  9. Studsvik Processing Facility Update

    SciTech Connect

    Mason, J. B.; Oliver, T. W.; Hill, G. M.; Davin, P. F.; Ping, M. R.

    2003-02-25

    Studsvik has completed over four years of operation at its Erwin, TN facility. During this time period Studsvik processed over 3.3 million pounds (1.5 million kgs) of radioactive ion exchange bead resin, powdered filter media, and activated carbon, which comprised a cumulative total activity of 18,852.5 Ci (6.98E+08 MBq). To date, the highest radiation level for an incoming resin container has been 395 R/hr (3.95 Sv/h). The Studsvik Processing Facility (SPF) has the capability to safely and efficiently receive and process a wide variety of solid and liquid Low Level Radioactive Waste (LLRW) streams including: Ion Exchange Resins (IER), activated carbon (charcoal), graphite, oils, solvents, and cleaning solutions with contact radiation levels of up to 400 R/hr (4.0 Sv/h). The licensed and heavily shielded SPF can receive and process liquid and solid LLRWs with high water and/or organic content. This paper provides an overview of the last four years of commercial operations processing radioactive LLRW from commercial nuclear power plants. Process improvements and lessons learned will be discussed.

  10. Meningomylocele: An update

    PubMed Central

    Kapoor, R.; Agrawal, S.

    2007-01-01

    Therapy-resistant overactivity of detrusor or small capacity and poor compliance, will usually need to be treated by bladder augmentation. Ileal or colonic patches are used frequently for augmenting the bladder, with either intestinal segment appearing to be equally useful. Stomach is rarely used because of the associated complications, but it is the only available intestinal segment for patients with impaired renal function. Concerns regarding long-term effects of associated metabolic acidosis, including abnormalities in linear growth and bone metabolism are misplaced. Ureterocystoplasty offers an attractive urothelium-preserving alternative, avoiding the metabolic complications, mucus production and cancer risk of heterotopic epithelium associated with enterocystoplasty. Though ideal for patients with dilated ureter and nonfunctioning kidney, in patients with functioning kidney it carries added risks associated with transuretero-ureterostomy, mainly obstruction. Ureteral dilatation in meningomyelocele patients is avoidable with proper follow-up and treatment. Therefore they rarely should be candidates for this operation. Alternative urothelium-preserving techniques, such as auto augmentation and seromuscular cystoplasty, have not proven to be as successful as standard augmentation with intestinal segment. Work is in progress on various bioengineering techniques to culture and combine bladder cells in tissue culture for regeneration. Early efforts are exciting, but preliminary. PMID:19675798

  11. Osteoporosis: an update.

    PubMed

    el-Hajj Fuleihan, G

    1998-01-01

    Prevention is the therapy of choice for optimizing skeletal health and preventing osteoporosis. Attempts directed at increasing peak bone mass (e.g., good calcium intake during preadolescence, adolescence, and adulthood), reducing risk factors for bone loss such as menstrual abnormalities, thin body habitus, decreased physical activity or excessive alcohol intake, and slowing down bone loss and reversing any causes of secondary bone loss should be pursued vigorously. In practice, all patients should be encouraged to get regular exercise, as well as adequate vitamin D and calcium intake. In the absence of contraindications, estrogen is the mainstay therapy for the prevention and treatment of osteoporosis. Other antiresorptive agents are available as alternative therapies to estrogen. Of equal importance to elderly women with established osteoporosis is counseling on how to prevent falls. Therapies that increase bone formation (aside from fluoride), including growth factors, are not currently available. However, such interventions used in conjunction with an antiresorptive therapy, offer the potential to greatly enhance and therefore normalize bone mass and may hold a promise for the treatment of osteoporosis in the future.

  12. WFGD system materials cost update

    SciTech Connect

    Milobowski, M.G.

    1998-12-31

    This paper is an update of the report ``Economic Comparison of Materials of Construction of Wet FGD Absorbers and Internals`` which was presented at the 1991 EPRI/EPA/DOE SO{sub 2} Control symposium. An economic comparison of the materials standardly used for fabrication of wet FGD spray towers will be presented in this paper. Costs for various materials of construction for such absorber components as spray headers, moisture separators, and gas distribution devices will also be addressed,

  13. GPS Modernization and Program Update

    DTIC Science & Technology

    2011-03-02

    2 March 2011 Colonel Bernie Gruber Director Global Positioning Systems Directorate 2011 03 03 Munich Summit v8 GPS Modernization and Program Update...Munich Summit v8 Global Positioning Systems Directorate Mission: Deliver sustained, reliable GPS capabilities to America’s warfighters, our allies...5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Air Force Space Command,Space & Missile Systems Center, Global Positioning

  14. Global update: Malaysia.

    PubMed

    1993-01-01

    Malaysia produces more condoms than any other country in the world, yet it has one of the lowest per capita condom usage rates. The official number of HIV-infected persons and of persons with AIDS in Malaysia is 5140 and 72, respectively. People working in AIDS prevention efforts believe the actual number of HIV-infected people is closer to 50,000 and climbing. People working in AIDS prevention efforts believe the actual number of HIV-infected people is closer to 50,000 and climbing. Public health officials report that AIDS is spreading rapidly through Malaysia's relatively large population of IV drug users. The Ministry of Health wants to introduce comprehensive and pragmatic efforts to stem the AIDS epidemic. They include sex education in schools, ways to prevent IV drug users from sharing needles, promotion of condoms among high risk groups, and screening to monitor HIV transmission. Islamic and Catholic groups oppose these program and policy measures, however. The new director of the Ministry's AIDS prevention unit announced during a meeting of health officials that a return to the teaching of Islam and adoption of Islamic values are the means to deal with AIDS. He suggested that boys and girls be separated, television be rigorously censored, and that Muslim scholars not be limited to mosques to do their teaching. The government has greatly increased the 1993 AIDS budget with all of the funds dedicated to blood screening, nongovernmental organizations (NGOs), and health education. The deputy health minister noted that the NGOs are supposed to address the more sensitive issues. The government does not allow any of the funds to directly go to condom promotion or programs for IV drug users, however.

  15. Human teratogens: update 2010.

    PubMed

    Holmes, Lewis B

    2011-01-01

    A wide variety of human teratogens have been identified. The characteristics of human teratogens can be used in the assessment of apparent "new" teratogens, when postulated. Information is available through online databases, such as TERIS and Reprotox, telephone-based counseling resources (e.g., Organization of Teratogen Information Systems [OTIS] and European Network Teratology Information Services [ENTIS]), reference books, annual meetings of the Teratology Society, and published articles. There are significant deficiencies in the information available: (1) lack of knowledge about the molecular and cellular basis for most teratogenic effects; (2) the inability to genetically identify more susceptible women before pregnancy; (3) little information is available on dermal and airborne exposures during pregnancy; and (4) most clinicians receive little, if any, training in the identification of or counseling for exposure to potential teratogens. There are many current dilemmas in counseling about exposures in pregnancy, including: (1) Is exposure to specific drugs, such as selected serotonin re-uptake inhibitors (SSRIs) and the inhibitors of tumor necrosis factor-alpha, teratogenic in the first trimester of pregnancy? (2) Are the increased risks of birth defects associated with assisted reproductive technology due, in part, to epigenetic effects? (3) What are the "safe" levels of exposure to the plasticizers phthalates during pregnancy? (4) How do we convince busy physicians, nurses, and pharmacists not to use the drug categories A, B, C, D, and X in counseling and to use more accurate sources? There is a need for a national advisory center for pregnancy registries to provide guidance when new registries are being developed.

  16. Orthokeratology review and update.

    PubMed

    Swarbrick, Helen A

    2006-05-01

    Orthokeratology (OK) is a clinical technique that uses specially designed rigid contact lenses to reshape the cornea to temporarily reduce or eliminate refractive error. This article reviews the history of traditional daily-wear OK (1960s to 1980s) and discusses the reasons for the recent resurgence in interest in the new modality of overnight OK, using reverse-geometry lens designs (1990s to the present). The clinical efficacy of the current procedure is examined and outcomes from clinical studies in terms of refractive error change and unaided visual acuity are summarised. Onset of the effects of overnight OK lens wear is rapid, with most change after the first night of lens wear and stability of refractive change after seven to 10 days. Mean reductions in myopic refractive error of between 1.75 and 3.33 D and individual reductions of up to 5.00 D have been reported. There appear to be slight reductions or minimal changes in astigmatism with the use of reverse-geometry lenses and most patients are reported to achieve 6/6 unaided vision or better. The induction of higher order aberrations, in particular, spherical aberration, has been reported and this may affect subjective vision under conditions of low contrast and pupil dilation. Patient satisfaction with overnight OK has been reported as similar to or better than with other popular modalities of contact lens wear. Available evidence suggests that the corneal changes induced by overnight OK are fully reversible. The refractive effect in OK is achieved by central epithelial thinning and this has raised concerns about compromise of the epithelial barrier to microbial infection. Recent reports of microbial keratitis in the modality are reviewed and the overall safety of the procedure is examined critically. Recent research on stromal contributions to the OK effect, particularly relating to overnight oedema, is summarised. Emerging issues in OK, including myopic control, correction of other refractive errors and

  17. Multiple sclerosis update.

    PubMed

    Markowitz, Clyde E

    2013-11-01

    Multiple sclerosis (MS) is a chronic but incurable disease of the central nervous system (CNS) that is often diagnosed in the second or third decade of life. It is more common among women than men, significantly impairs patient quality of life, and is associated with substantial costs to patients, healthcare systems, and society. Of the approximately 2.3 million individuals worldwide that have MS, more than 400,000 reside in the United States. Although the etiology of MS is not completely understood, a great deal of evidence suggests a complex relationship between environmental and genetic factors. The pathophysiology of MS involves an aberrant attack by the host immune system on oligodendrocytes, which synthesize and maintain myelin sheaths in the CNS. There are 4 identified disease courses in MS, and approximately 85% of people with MS present with relapsing-remitting MS, which is characterized by discrete acute attacks followed by periods of remission. Signs and symptoms of MS are dependent on the demyelinated area(s) of the CNS and often involve sensory disturbances, limb weakness, fatigue, and increased body temperature. The criteria for a diagnosis of MS include evidence of damage in at least 2 separate areas of the CNS, evidence that the damage occurred at different time points, and the ruling out of other possible diagnoses. Diseasemodifying drugs (DMDs) that reduce the frequency of relapses, development of brain lesions, and progression of disability are the standard of care for relapsing forms of MS, and the use of DMDs should be initiated as early as possible.

  18. Melasma--updated treatments.

    PubMed

    Situm, Mirna; Kolić, Maja; Bolanca, Zeljana; Ljubicić, Ivana; Misanović, Bernarda

    2011-09-01

    Melasma is a common, acquired facial skin disorder, mostly involving sun-exposed areas like cheeks, forehead and upper lip. Melasma occurs in both sexes, although almost 90 percent of the affected are women. It is more common in darker skin types (Fitzpatrick skin types IV to VI) especially Hispanics/Latinos, Asians and African-Americans. The onset of the melasma is at puberty or later, with exception of darker skin types, who tend to develop this problem in the first decade of life. The etiology is still unknown, although there are a number of triggering factors related to the onset of melasma. The most important are sun-exposure and genetic factors in both sexes, while hormonal activity has more important role in females. In addition, stress and some cosmetic products and drugs containing phototoxic agents can cause outbreaks of this condition. Melasma should be treated using monotherapies or combination of therapy, mainly fixed triple or dual combinations containing hydroquinone, tretinoin, corticosteroids or azelaic acid. Modified Kligman's formula is also very effective. Above mentioned therapy regimens in combination with UVA and UVB blocking sunscreens are mostly effective in epidermal melasma. Discontinuation of the use of birth control pills, scented cosmetic products, and phototoxic drugs coupled with UV protection are also benefitial in clearing of melasma. Alternative treatment including chemical peels and glicolic acid, seem to have the best result as a second line treatment after bleaching creams. Laser treatments show limited efficacy and should rarely be used in the treatment of melasma. Combining topical agents like hydroquinone, tretinoin and a corticosteroid in addition to sun avoidance, regular use of sunscreen throughout the year and patient education is the best treatment in this difficult to treat condition.

  19. [Gout management: an update].

    PubMed

    Ankli, Barbara; Krähenbühl, Stephan

    2016-01-01

    Gout is the most frequent arthritis worldwide. Despite progress in therapeutic options the majority of gout patients are still insufficiently treated. International guidelines (ACR, EULAR, 3e initiative) clearly specify treatment targets: keep the patient flare-free and maintain a low urate serum level (< 360 µmol/l). The treat to target strategy includes therapy of flares, urate lowering treatment (ULT) and prophylaxis of flares. Evolution of gout guidelines over several years shows a broader indication for ULT, mandatory prophylaxis of flares during the initiation of ULT over several months and an earlier start of ULT in patients with flares as soon as symptoms have diminished. Colchicine is the preferred specific flare treatment, Caution has to be taken especially in patients with kidney disease, patients with hepatic dysfunction or in patients with interacting comedication. Low dose oral colchicine is nowadays the standard flare treatment. NSAIDs and prednisone are valuable alternatives. Interleukin-1 blockers offer a quick resolution of flares and may be an option in patients with chronic gout and severe kidney disease. Xanthinoxidase inhibitors (XOI) are the mainstay of ULT, with allopurinol still being the preferred XOI. The recently approved XOI febuxostat is eliminated mostly by the liver and can induce a faster lowering of urate. Uricosuric drugs such as probenecid are recommended in patients with sufficient renal function in whom the treatment goals cannot be reached with XOI. In Switzerland, only the two gout-lowering drugs allopurinol and probenecid are available, which reduces the therapeutic possibilities. Treatment success is often hampered by malcompliance. Recent guidelines stress the importance of patient education to ameliorate compliance. Comorbidities such as metabolic syndrome, cardiovascular and kidney disease are often found in gout patients. Patients with severe kidney disease are the most difficult to treat: the choice of

  20. 78 FR 79501 - Tennessee Valley Authority, Exemption From the Requirement To Submit an Annual Update to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Safety Analysis Report Included in a Combined License Application AGENCY: Nuclear Regulatory Commission... submit updates to the Final Safety Analysis Report (FSAR) included in their COL Application until... submit COL application Final Safety Analysis Report (FSAR) updates. 2.0 Request/Action 10 CFR...

  1. NEWS: Post-16 update

    NASA Astrophysics Data System (ADS)

    Campbell, Peter

    2000-07-01

    sometimes hard-to-come-by information, insightful and occasionally witty comment and illustration. The fifth booklet, published in April this year, rounds off the series so far. For those who have not yet seen them, here are the questions that the booklets have explored: Making Physics Connect (editor: Peter Campbell). How can physics courses connect better with the learner and with other human activities and areas of knowledge? Physics in Mathematical Mood (editor: Simon Carson). How can we teach physics in an appropriately mathematical way, conveying the beauty and power of mathematical reasoning to students? Physics in Vocational Courses (editor: Ken Gadd). In the new National Qualifications Framework, what role should physics play in the `general vocational' and `vocational' pathways? The Study of Matter (editor: Claire Davis). What aspects of a wide and interdisciplinary subject should be included in courses at advanced level, and how can these best be taught? Revitalising Physics Education (editor: Andrew Morris). What can we learn from histories of physics and of education, or from curriculum development projects of the last thirty years? What can be said about teaching and learning physics beyond qualifications, or learned from international developments in physics education? These booklets should find their way into every physics department in the UK. They will be of immediate practical use in schools or colleges, informing teaching while also providing stimulus material for discussion among physics teachers. (The latter would rightly be called in-service training.) Student teachers will find them a good guide covering new terrain. Lecturers at higher education level will gain valuable insight into changes affecting their undergraduate intake. And the physics advisory committee of every Awarding Body will surely want to discuss issues raised in the booklets. The main message overall is that, to meet tomorrow's challenges, the many parties involved in physics

  2. Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-11-01

    . Provided the tasks are well defined and the marking criteria are straightforward to apply, internally assessed work provides an opportunity for real positive achievement; students are able to control the task they set themselves, and have every opportunity to maximize their marks. In the past most syllabuses used the coursework simply to assess experimental and investigative skills, through a series of experiments or a practical investigation. Two of the new specifications have taken the opportunity to broaden the scope of coursework. The Edexcel Salters - Horners Advanced Physics AS course includes a report on a visit. Students must make a visit to an establishment where physics is in action, and then report on how physics is used there. The visit may be to a local garage, supermarket or hospital, but could use any other local resource - or indeed justify that trip to CERN. The location of the visit is limited only by the imagination of teachers and students. In the AS course of OCR Advancing Physics students must make a presentation about a material they have studied. The presentation may be a talk, a poster or even a series of web pages. This gives students the opportunity to demonstrate their key skills in communication alongside collecting some marks towards their AS in Physics. In the A2 year students develop their research skills further by producing a research report on a topic of their choice. Students must show how they can draw together ideas from different aspects of physics in discussing their chosen subject. These two developments lead the way in encouraging teachers and examiners to take physics out of the school laboratory and into the world. Mary Whitehouse

  3. Preeclampsia: an update.

    PubMed

    Lambert, G; Brichant, J F; Hartstein, G; Bonhomme, V; Dewandre, P Y

    2014-01-01

    Preeclampsia was formerly defined as a multisystemic disorder characterized by new onset of hypertension (i.e. systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg) and proteinuria (> 300 mg/24 h) arising after 20 weeks of gestation in a previously normotensive woman. Recently, the American College of Obstetricians and Gynecologists has stated that proteinuria is no longer required for the diagnosis of preeclampsia. This complication of pregnancy remains a leading cause of maternal morbidity and mortality. Clinical signs appear in the second half of pregnancy, but initial pathogenic mechanisms arise much earlier. The cytotrophoblast fails to remodel spiral arteries, leading to hypoperfusion and ischemia of the placenta. The fetal consequence is growth restriction. On the maternal side, the ischemic placenta releases factors that provoke a generalized maternal endothelial dysfunction. The endothelial dysfunction is in turn responsible for the symptoms and complications of preeclampsia. These include hypertension, proteinuria, renal impairment, thrombocytopenia, epigastric pain, liver dysfunction, hemolysis-elevated liver enzymes-low platelet count (HELLP) syndrome, visual disturbances, headache, and seizures. Despite a better understanding of preeclampsia pathophysiology and maternal hemodynamic alterations during preeclampsia, the only curative treatment remains placenta and fetus delivery. At the time of diagnosis, the initial objective is the assessment of disease severity. Severe hypertension (SBP ≥ 160 mm Hg and/or DBP ≥ 110 mmHg), thrombocytopenia < 100.000/μL, liver transaminases above twice the normal values, HELLP syndrome, renal failure, persistent epigastric or right upper quadrant pain, visual or neurologic symptoms, and acute pulmonary edema are all severity criteria. Medical treatment depends on the severity of preeclampsia, and relies on antihypertensive medications and magnesium sulfate. Medical treatment

  4. NEWS: Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-05-01

    (post16) Making physics connect Doesn't Melvyn Bragg do a wonderful job, engaging both scientists and artists in sensitive discussion on Radio 4 about their methods and their purposes? But every week teachers have the chance to show their students that physics is a way of seeing the world that is well-connected with other aspects of knowledge and culture. The stakes are high: students who fail to appreciate this generally choose not to study the subject beyond GCSE. Most students find our preoccupation with technical detail off-putting. Accepting that we have a syllabus to cover, it's still a question of balance. In our teaching we should aim for variety in order to find ways to connect with every student's interests. Also, we can show that we (the nearest embodiment of a physicist some students will experience) are multidimensional and so fully human. Most important, teachers need flexibility to both encourage and respond to student comment and questions. The first booklet in the discussion series Shaping the Future takes up these themes. Rich in ideas for both immediate use and the longer term, it aims to stimulate debate and improve teaching. Copies cost £5.50 including postage and are available from Ingrid Ebeyer, Post-16 Initiative, Institute of Physics, 76 Portland Place, London W1N 3DH. How far is it? This question is asked in many family cars and school minibuses at the start of a journey, and answered by most in terms of hours and minutes rather than miles. What a good idea for introducing a social and historical perspective to a lesson on distance, velocity and time. How far can you actually get in a day? What is the range of human activity? Walking for eight hours will get many people about 25 miles. A pack horse will progress at much the same rate, but fast riding or a coach and team of horses will get further. Motorway driving (when the cones are on holiday) would take you nearly 500 miles. The 05.15 am train from Penzance arrives in Inverness at 7

  5. Pittsburgh Registry of Infant Multiplets (PRIM): an update.

    PubMed

    Jenkins, Elizabeth A; Maher, Brion S; Marazita, Mary L; Tarter, Ralph E; Ganger, Jennifer B; Watt-Morse, Margaret; Vanyukov, Michael M

    2006-12-01

    This article is an updated review of the Pittsburgh Registry of Infant Multiplets including recruitment methods, data collection, and results of pilot studies conducted in this registry. The main goal of the registry is to study psychological development. The risk for behavior disorders including substance use disorders, as well as language development and dental health are among research targets. Pilot data on the heritability of minor physical anomalies and neuropsychological characteristics (Continuous Performance Test) are reported.

  6. Partial Updating of TSCA Inventory DataBase; Production and Site Reports; Final Rule

    EPA Pesticide Factsheets

    A partial updating of the TSCA inventory database. The final rule requires manufacturers and importers of certain chemical substances included on the TSCA Chemical Substances Inventory to report current data on the production volume, plant site, etc.

  7. 77 FR 37617 - Updating OSHA Standards Based on National Consensus Standards; Head Protection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... following section titled ADDRESSES describes methods available for making submissions.) ADDRESSES: Submit...-02 Colorimetry--Standard Practice for Obtaining Spectrophotometric Data for Object- Color Evaluation... and test methods. Accordingly, the 2009 edition includes fundamental updates such as more...

  8. Progress on Updating the 1961-1990 National Solar Radiation Database

    NASA Technical Reports Server (NTRS)

    Renne, D.; Wilcox, S.; Marion, B.; George, R.; Myers, D.

    2003-01-01

    The 1961-1990 National Solar Radiation Data Base (NSRDB) provides a 30-year climate summary and solar characterization of 239 locations throughout the United States. Over the past several years, the National Renewable Energy Laboratory (NREL) has received numerous inquiries from a range of constituents as to whether an update of the database to include the 1990s will be developed. However, there are formidable challenges to creating an update of the serially complete station-specific database for the 1971-2000 period. During the 1990s, the National Weather Service changed its observational procedures from a human-based to an automated system, resulting in the loss of important input variables to the model used to complete the 1961-1990 NSRDB. As a result, alternative techniques are required for an update that covers the 1990s. This paper examines several alternative approaches for creating this update and describes preliminary NREL plans for implementing the update.

  9. Environmental Chemistry Update

    NASA Astrophysics Data System (ADS)

    1995-08-01

    the OH/HOO reaction chain is responsible for 30-50% of the ozone loss in the low stratosphere. Chains involving nitrogen radicals are less important in this region than previously thought. Almost one-third of the loss is due to cycles involving halogens, including that initiated by collision of ClO with Br. Equally important is the following cycle, reminiscent of the "dimer" mechanism that operates in ozone holes, for the 2O3 --> 3O2 process. Cl + O3 --> ClO + O2 OH + O3 --> HOO + O2 ClO + HOO --> HOCl + O2 HOCl + sunlight --> OH + Cl The same mechanism with bromine replacing chlorine is also important. The greatest removal rate for ozone at these latitudes should occur in spring and fall, when ozone production is minimal. Although the sunlight then is not sufficient to dissociate much O2, it is adequate to drive the free radical processes (7). The feasibility of A. Y. Wong's scheme to reduce stratospheric ozone destruction due to reactions involving chlorine has been questioned. The scheme involves the introduction of electrons into the stratosphere, which would allow the conversion of chlorine to chloride ion and its hydrates and potentially the subsequent removal of the chloride ions. A. A. Viggiano and colleagues have noted that chloride ions react quickly after their formation (to reform chlorine radicals) and never amount to more than a tiny fraction of the anions present. The dominant ions are NO3- and CO3-. Viggiano et al. also note the very large energy requirements for the electron production and for removal of the 2.4 X 10^9 kg of chlorine from the stratosphere (8). Pesticides and DioxinGreat LakesThe herbicide atrazine and its metabolite, in which the nitrogen-based ethyl group is removed, were found in all 490 samples of water from the Great Lakes in a 1990-1992 study. Highest concentrations of atrazine were found in Lakes Ontario and Erie (70-110 parts per trillion (ppt)), with lower levels (20-35 ppt) in Lakes Huron and Michigan. It was estimated that

  10. Numerical Modeling of Electroacoustic Logging Including Joule Heating

    NASA Astrophysics Data System (ADS)

    Plyushchenkov, Boris D.; Nikitin, Anatoly A.; Turchaninov, Victor I.

    It is well known that electromagnetic field excites acoustic wave in a porous elastic medium saturated with fluid electrolyte due to electrokinetic conversion effect. Pride's equations describing this process are written in isothermal approximation. Update of these equations, which allows to take influence of Joule heating on acoustic waves propagation into account, is proposed here. This update includes terms describing the initiation of additional acoustic waves excited by thermoelastic stresses and the heat conduction equation with right side defined by Joule heating. Results of numerical modeling of several problems of propagation of acoustic waves excited by an electric field source with and without consideration of Joule heating effect in their statements are presented. From these results, it follows that influence of Joule heating should be taken into account at the numerical simulation of electroacoustic logging and at the interpretation of its log data.

  11. Sensitive chiral analysis by CE: an update.

    PubMed

    Sánchez-Hernández, Laura; Crego, Antonio Luis; Marina, María Luisa; García-Ruiz, Carmen

    2008-01-01

    A general view of the different strategies used in the last years to enhance the detection sensitivity in chiral analysis by CE is provided in this article. With this purpose and in order to update the previous review by García-Ruiz et al., the articles appeared on this subject from January 2005 to March 2007 are considered. Three were the main strategies employed to increase the detection sensitivity in chiral analysis by CE: (i) the use of off-line sample treatment techniques, (ii) the employment of in-capillary preconcentration techniques based on electrophoretic principles, and (iii) the use of alternative detection systems to the widely employed on-column UV-Vis absorption detection. Combinations of two or three of the above-mentioned strategies gave rise to adequate concentration detection limits up to 10(-10) M enabling enantiomer analysis in a variety of real samples including complex biological matrices.

  12. Berberis Vulgaris and Berberine: An Update Review.

    PubMed

    Imenshahidi, Mohsen; Hosseinzadeh, Hossein

    2016-11-01

    Berberine is an isoquinoline alkaloid present in several plants, including Coptis sp. and Berberis sp. Berberine is a customary component in Chinese medicine, and is characterized by a diversity of pharmacological effects. An extensive search in electronic databases (PubMed, Scopus, Ovid, Wiley, ProQuest, ISI, and Science Direct) were used to identify the pharmacological and clinical studies on Berberis vulgaris and berberine, during 2008 to 2015, using 'berberine' and 'Berberis vulgaris' as search words. We found more than 1200 new article studying the properties and clinical uses of berberine and B. vulgaris, for treating tumor, diabetes, cardiovascular disease, hyperlipidemia, inflammation, bacterial and viral infections, cerebral ischemia trauma, mental disease, Alzheimer disease, osteoporosis, and so on. In this article, we have updated the pharmacological effects of B. vulgaris and its active constituent, berberine. Copyright © 2016 John Wiley & Sons, Ltd.

  13. An Update on the KFIB Experiment

    SciTech Connect

    Youngblood, Gerald E.; Jones, Russell H.; Kowbel, W.; De Heij, Paul; Kohyama, Akira

    2001-06-30

    An updated sample test matrix for the KFIB experiment is presented. The pre-irradiation test results for all fiber and SiC/SiC composite materials included in the test matrix, recently presented at the 4th IEA Workshop on SiC/SiC for Fusion Structural Applications held in Frascati, Italy, October 12-13, 2000, are reviewed. The KFIB samples have been delivered for capsule loading. They are scheduled to be irradiated from May through October, 2001 to similar doses (2-4 dpa-SiC) in the ATR (Idaho Falls) at 300?C and the HFR (Petten) at 625 and 975?C. To assess irradiation enhanced creep (IEC) in SiC fibers, a bend stress relaxation module was added to the HFR sample matrix at each irradiation temperature.

  14. Update on proprioception: considerations for dance education.

    PubMed

    Batson, Glenna

    2009-01-01

    Proprioception is a topic of interest within the larger scope of dance pedagogy, science, and rehabilitation. As the science of proprioception changes, approaches to proprioceptive training also change. Thus, proprioceptive training in dance medicine has expanded to include balance protocols. A key concept within these protocols for treatment of lower extremity injuries is perturbation. Perturbation training is designed to evoke focal neuromuscular control at injured joint sites, as well as more global postural responses for overall balance and coordination. This article provides an update on the science of proprioception within the framework of postural control and balance. Specific practices from rehabilitation that integrate balance exercises into proprioceptive training are considered. Further research is needed to test the efficacy and utility of these exercises within the context of the dance studio.

  15. [Sexually transmitted diseases--an update].

    PubMed

    Davidovitch, Nadav; Shohat, Tami; Dan, Michael

    2005-04-01

    Sexually transmitted infections represent an worldwide challenge for the public health. According to WHO estimates, approximately 330 million people are infected annually by curable sexually transmitted infections (AIDS excluded). and their incidence has been increasing, particularly in high-risk populations. Like in other developed countries, the occurrence of venereal diseases in Israel has been increasing recently. In addition, a sharp rise has been observed in the resistance rate of gonococci to fluoroquinolones. The purpose of the present review is to update the information on the epidemiology, diagnosis, therapy and prevention of sexually transmitted diseases (STDs) in Israel. In response to the reemergence of these diseases in Israel, it was decided in the Ministry of Health to open for the first time ever STD clinics in the two cities with the highest disease burden, namely Tel Aviv and Haifa. These clinics are staffed with a multidisciplinary group of specialists, including gynecologists, dermatologists, epidemiologists, nurses and social workers.

  16. Cardiovascular Regenerative Technologies: Update and Future Outlook

    PubMed Central

    Mallone, Anna; Weber, Benedikt; Hoerstrup, Simon P.

    2016-01-01

    In the effort of improving treatment for cardiovascular disease (CVD), scientists struggle with the lack of the regenerative capacities of finally differentiated cardiovascular tissues. In this context, the advancements in regenerative medicine contributed to the development of cell-based therapies as well as macro- and micro-scale tissue-engineering technologies. The current experimental approaches focus on different regenerative strategies including a broad spectrum of techniques such as paracrine-based stimulation of autologous cardiac stem cells, mesenchymal cell injections, 3D microtissue culture techniques and vascular tissue-engineering methods. These potential next-generation strategies are leading the way to a revolution in addressing CVD, and numerous studies are now undertaken to assess their therapeutic value. With this review, we provide an update on the current research directions, on their major challenges, limitations, and achievements. PMID:27721705

  17. Stem Cells News Update: A Personal Perspective

    PubMed Central

    Wong, SC

    2013-01-01

    This article is a follow-up to a previous Commentary published in 2011. It updates some of the events mentioned in that Commentary and continues with more interesting and exciting news on stem cell research and the emerging field of Regenerative Medicine. Some of the news includes: 1) the 2012 Nobel Prize for Medicine awarded to John B. Gurdon and Shinya Yamanaka; 2) the cloning of human embryonic stem cells; 3) the continued search for truly pluripotent adult stem cells via in vitro and in vivo protocols; 4) the breakthrough in organ replacements; 5) the global stem cell race; 6) the global stem cell cryo-preservation business; 7) the worldwide stem cell donor registries, and 8) the issue of government regulation on stem cell therapy. PMID:24778557

  18. Calmodulin inhibitors from natural sources: an update.

    PubMed

    Mata, Rachel; Figueroa, Mario; González-Andrade, Martín; Rivera-Chávez, José Alberto; Madariaga-Mazón, Abraham; Del Valle, Paulina

    2015-03-27

    Calmodulin (CaM) plays a central role in regulating a myriad of cellular functions in physiological and pathophysiological processes, thus representing an important drug target. In previous reviews, our group has reported relevant information regarding natural anti-CaM compounds up to 2009. Natural sources continue to provide a diverse and unique reservoir of CaM inhibitors for drug and research tool discovery. This review provides an update of natural products with reported CaM inhibitory properties, which includes around 70 natural products and some synthetic analogues, belonging to different structural classes. Most of these natural inhibitors were isolated from fungi and plants and belong to the stilbenoid, polyketide, alkaloid, and peptide structural classes. These products were discovered mainly using a fluorescence-based method on rationally designed biosensors, which are highly specific, low-cost, and selective and have short reaction times. The effect of several antimitotic drugs on Ca(2+)-hCaM is also described.

  19. THE MAJORANA DEMONSTRATOR: OVERVIEW AND STATUS UPDATE

    SciTech Connect

    Keeter, K.; Abgrall, N.; Aguayo, Estanislao; Avignone, F. T.; Barabash, Alexander; Bertrand, F.; Boswell, M.; Brudanin, V.; Busch, Matthew; Caldwell, A. S.; Chan, Yuen-Dat; Christofferson, Cabot-Ann; Combs, Dustin C.; Cuesta, C.; Detwiler, Jason A.; Doe, Peter J.; Efremenko, Yuri; Egorov, Viatcheslav; Ejiri, H.; Elliott, S.; Esterline, James H.; Fast, James E.; Finnerty, P.; Fraenkle, Florian; Galindo-Uribarri, A.; Giovanetti, G. K.; Goett, J.; Green, Matthew P.; Gruszko, J.; Guiseppe, Vincente; Gusev, K.; Hallin, A. L.; Hazama, R.; Hegai, A.; Henning, Reyco; Hoppe, Eric W.; Howard, Stanley; Howe, M. A.; Kidd, M. F.; Kochetov, Oleg; Konovalov, S.; Kouzes, Richard T.; LaFerriere, Brian D.; Leon, Jonathan D.; Leviner, L.; Loach, J. C.; MacMullin, S.; Martin, R. D.; Mertens, S.; Mizouni, Leila; Nomachi, Masaharu; O'Shaughnessy, Mark D.; Orrell, John L.; Overman, Nicole R.; Phillips, D.; Poon, Alan; Pushkin, K.; Radford, D. C.; Rielage, Keith; Robertson, R. G. H.; Ronquest, M. C.; Schubert, Alexis G.; Shanks, B.; Shima, T.; Shirchenko, M.; Snavely, Kyle J.; Snyder, N.; Soin, Aleksandr; Strain, J.; Suriano, Anne-Marie; Swift, Gary; Thompson, J.; Timkin, V.; Tornow, Werner; Varner, R. L.; Vasilyev, Sergey; Vetter, Kai; Vorren, Kris R.; White, Brandon R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Young, A.; Yu, Chang-Hong; Yumatov, Vladimir

    2013-04-12

    The MAJORANA DEMONSTRATOR is being constructed at the Sanford Underground Research Facility (SURF) in Lead, SD by the MAJORANA Collaboration to demonstrate the feasibility of a tonne-scale neutrinoless double beta decay experiment based on 76Ge. The observation of neutrinoless double beta decay would indicate that neutrinos can serve as their own antiparticles, thus proving neutrinos to be Majorana particles, and would give information on neutrino masses. Attaining sensitivities for neutrino masses in the inverted hierarchy region requires large tonne-scale detectors with extremely low backgrounds. The DEMONSTRATOR project will show that sufficiently low backgrounds are achievable. A brief description of the detector and a status update on the construction will be given, including the work done at BHSU on acid-etching of Pb shielding bricks.

  20. Resource Tracking Model Updates and Trade Studies

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe; Stambaugh, Imelda; Moore, Michael

    2016-01-01

    The Resource Tracking Model has been updated to capture system manager and project manager inputs. Both the Trick/General Use Nodal Network Solver Resource Tracking Model (RTM) simulator and the RTM mass balance spreadsheet have been revised to address inputs from system managers and to refine the way mass balance is illustrated. The revisions to the RTM included the addition of a Plasma Pyrolysis Assembly (PPA) to recover hydrogen from Sabatier Reactor methane, which was vented in the prior version of the RTM. The effect of the PPA on the overall balance of resources in an exploration vehicle is illustrated in the increased recycle of vehicle oxygen. Case studies have been run to show the relative effect of performance changes on vehicle resources.

  1. CALIPSO Mission Status Update: Payload Status

    NASA Technical Reports Server (NTRS)

    Verhappen, Ron; Borchardt, Robert; MacDonnell, David; Cisewski, Mike

    2007-01-01

    The CALIPSO mission payload status update is presented. The contents include: 1) Wide Field Camera Overview; 2) WFC Temperatures; 3) WFC Voltages; 4) Imaging Infrared Radiometer (IIR) Health; 5) IIR Voltages; 6) Payload Control (PLC) Voltages; 7) PLC Temperatures; 8) Low Voltage Power Supply (LVPS) (CALOPS0025N); 9) PLC Radiation Effects; 10) SDS Status (CALOPS0020N); 11) CALIOP LIDAR; 12) Laser Energy Trends; 13) Laser Energy Zoom; 14) Laser Management Approach; 15) Green / Red Ratio; 16) Pedestal @ SHG Temperature Trends; 17) LOM Heater Duty Cycle Trends; 18) LOM Pressure Trends; 19) Boresight Trend; 20) 1064 Dark Noise Trend; 21) 532 SNR Trend; 22) Spike Trends; 23) LIDAR Highlights; 24) Backup Laser Status; and 25) Future Plans.

  2. Resource Tracking Model Updates and Trade Studies

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe; Stambaugh, Imelda; Moore, Michael

    2016-01-01

    The Resource tracking model has been updated to capture system manager and project manager inputs. Both the Trick/GUNNS RTM simulator and the RTM mass balance spreadsheet have been revised to address inputs from system managers and to refine the way mass balance is illustrated. The revisions to the RTM included addition of a Plasma Pyrolysis Assembly (PPA) to recover hydrogen from Sabatier reactor methane which was vented in the prior version of the RTM. The effect of the PPA on the overall balance of resources in an exploration vehicle is illustrated in the increased recycle of vehicle oxygen. Additionally simulation of EVAs conducted from the exploration module was added. Since the focus of the exploration module is to provide a habitat during deep space operations the EVA simulation approach to EVA is based on ISS EVA protocol and processes. Case studies have been run to show the relative effect of performance changes on vehicle resources.

  3. Hubble Space Telescope Battery Capacity Update

    NASA Technical Reports Server (NTRS)

    Hollandsworth, Roger; Armantrout, Jon; Rao, Gopalakrishna M.

    2007-01-01

    Orbital battery performance for the Hubble Space Telescope is discussed and battery life is predicted which supports decision to replace orbital batteries by 2009-2010 timeframe. Ground characterization testing of cells from the replacement battery build is discussed, with comparison of data from battery capacity characterization with cell studies of Cycle Life and 60% Stress Test at the Naval Weapons Surface Center (NWSC)-Crane, and cell Cycle Life testing at the Marshal Space Flight Center (MSFC). The contents of this presentation includes an update to the performance of the on-orbit batteries, as well as a discussion of the HST Service Mission 4 (SM4) batteries manufactured in 1996 and activated in 2000, and a second set of SM4 backup replacement batteries which began manufacture Jan 11, 2007, with delivery scheduled for July 2008.

  4. Pseudophakic cystoid macular edema: update 2016

    PubMed Central

    Grzybowski, Andrzej; Sikorski, Bartosz L; Ascaso, Francisco J; Huerva, Valentín

    2016-01-01

    Pseudophakic cystoid macular edema (PCME) is the most common complication of cataract surgery, leading in some cases to a decrease in vision. Although the pathogenesis of PCME is not completely understood, the contribution of postsurgical inflammation is generally accepted. Consequently, anti-inflammatory medicines, including steroids and nonsteroidal anti-inflammatory drugs, have been postulated as having a role in both the prophylaxis and treatment of PCME. However, the lack of a uniformly accepted PCME definition, conflicting data on some risk factors, and the scarcity of studies comparing the role of nonsteroidal anti-inflammatory drugs to steroids in PCME prevention make the problem of PCME one of the puzzles of ophthalmology. This paper presents an updated review on the pathogenesis, risk factors, and use of anti-inflammatory drugs in PCME that reflect current research and practice. PMID:27672316

  5. Sellafield Decommissioning Programme - Update and Lessons Learned

    SciTech Connect

    Lutwyche, P. R.; Challinor, S. F.

    2003-02-24

    The Sellafield site in North West England has over 240 active facilities covering the full nuclear cycle from fuel manufacture through generation, reprocessing and waste treatment. The Sellafield decommissioning programme was formally initiated in the mid 1980s though several plants had been decommissioned prior to this primarily to create space for other plants. Since the initiation of the programme 7 plants have been completely decommissioned, significant progress has been made in a further 16 and a total of 56 major project phases have been completed. This programme update will explain the decommissioning arrangements and strategies and illustrate the progress made on a number of the plants including the Windscale Pile Chimneys, the first reprocessing plan and plutonium plants. These present a range of different challenges and requiring approaches from fully hands on to fully remote. Some of the key lessons learned will be highlighted.

  6. Stem cells news update: a personal perspective.

    PubMed

    Wong, Sc

    2013-12-01

    This article is a follow-up to a previous Commentary published in 2011. It updates some of the events mentioned in that Commentary and continues with more interesting and exciting news on stem cell research and the emerging field of Regenerative Medicine. Some of the news includes: 1) the 2012 Nobel Prize for Medicine awarded to John B. Gurdon and Shinya Yamanaka; 2) the cloning of human embryonic stem cells; 3) the continued search for truly pluripotent adult stem cells via in vitro and in vivo protocols; 4) the breakthrough in organ replacements; 5) the global stem cell race; 6) the global stem cell cryo-preservation business; 7) the worldwide stem cell donor registries, and 8) the issue of government regulation on stem cell therapy.

  7. The universal tree of life: an update

    PubMed Central

    Forterre, Patrick

    2015-01-01

    Biologists used to draw schematic “universal” trees of life as metaphors illustrating the history of life. It is indeed a priori possible to construct an organismal tree connecting the three major domains of ribosome encoding organisms: Archaea, Bacteria and Eukarya, since they originated by cell division from LUCA. Several universal trees based on ribosomal RNA sequence comparisons proposed at the end of the last century are still widely used, although some of their main features have been challenged by subsequent analyses. Several authors have proposed to replace the traditional universal tree with a ring of life, whereas others have proposed more recently to include viruses as new domains. These proposals are misleading, suggesting that endosymbiosis can modify the shape of a tree or that viruses originated from the last universal common ancestor (LUCA). I propose here an updated version of Woese’s universal tree that includes several rootings for each domain and internal branching within domains that are supported by recent phylogenomic analyses of domain specific proteins. The tree is rooted between Bacteria and Arkarya, a new name proposed for the clade grouping Archaea and Eukarya. A consensus version, in which each of the three domains is unrooted, and a version in which eukaryotes emerged within archaea are also presented. This last scenario assumes the transformation of a modern domain into another, a controversial evolutionary pathway. Viruses are not indicated in these trees but are intrinsically present because they infect the tree from its roots to its leaves. Finally, I present a detailed tree of the domain Archaea, proposing the sub-phylum neo-Euryarchaeota for the monophyletic group of euryarchaeota containing DNA gyrase. These trees, that will be easily updated as new data become available, could be useful to discuss controversial scenarios regarding early life evolution. PMID:26257711

  8. Exercise-induced bronchoconstriction update-2016.

    PubMed

    Weiler, John M; Brannan, John D; Randolph, Christopher C; Hallstrand, Teal S; Parsons, Jonathan; Silvers, William; Storms, William; Zeiger, Joanna; Bernstein, David I; Blessing-Moore, Joann; Greenhawt, Matthew; Khan, David; Lang, David; Nicklas, Richard A; Oppenheimer, John; Portnoy, Jay M; Schuller, Diane E; Tilles, Stephen A; Wallace, Dana

    2016-11-01

    The first practice parameter on exercise-induced bronchoconstriction (EIB) was published in 2010. This updated practice parameter was prepared 5 years later. In the ensuing years, there has been increased understanding of the pathogenesis of EIB and improved diagnosis of this disorder by using objective testing. At the time of this publication, observations included the following: dry powder mannitol for inhalation as a bronchial provocation test is FDA approved however not currently available in the United States; if baseline pulmonary function test results are normal to near normal (before and after bronchodilator) in a person with suspected EIB, then further testing should be performed by using standardized exercise challenge or eucapnic voluntary hyperpnea (EVH); and the efficacy of nonpharmaceutical interventions (omega-3 fatty acids) has been challenged. The workgroup preparing this practice parameter updated contemporary practice guidelines based on a current systematic literature review. The group obtained supplementary literature and consensus expert opinions when the published literature was insufficient. A search of the medical literature on PubMed was conducted, and search terms included pathogenesis, diagnosis, differential diagnosis, and therapy (both pharmaceutical and nonpharmaceutical) of exercise-induced bronchoconstriction or exercise-induced asthma (which is no longer a preferred term); asthma; and exercise and asthma. References assessed as relevant to the topic were evaluated to search for additional relevant references. Published clinical studies were appraised by category of evidence and used to document the strength of the recommendation. The parameter was then evaluated by Joint Task Force reviewers and then by reviewers assigned by the parent organizations, as well as the general membership. Based on this process, the parameter can be characterized as an evidence- and consensus-based document.

  9. Development of Updated ABsorption SIMulation Software (ABSIM)

    SciTech Connect

    Yang, Zhiyao; Tang, Xin; Qu, Ming; Abdelaziz, Omar; Gluesenkamp, Kyle R

    2014-01-01

    ABsorption SIMulation, ABSIM, was developed for the simulation of absorption systems by The Oak Ridge National Laboratory during 1980s and 1990s. ABSIM provides a platform for users to investigate various cycle configurations and working fluids, to calculate their operating parameters, to predict their performance, and to compare them with each other on a uniform basis. ABSIM is indeed a very useful and accurate tool for researchers to investigate various absorption systems. However, it has not been well maintained: it is incompatible with recent operating systems; the interface needs improved user-friendliness, and the system needs better parameter setting and debugging tools to help achieve convergence. Therefore, it is highly needed to update and improve ABSIM. The paper presents recent efforts to improve ABSIM s compatibility with current operating systems, user interface, and analysis capabilities. The paper details the features and functions of the newly updated ABSIM software. The new ABSIM still uses the previously validated calculation engine of the old ABSIM. The new graphic user interfaces (GUI) were developed in Qt, which is an open source license GUI software based on C++. XML was used as the database for data storage in the new ABSIM. The new ABSIM has been designed to be easily learned and used. It has enhanced editing and construction functions, plus enhanced analysis features including parametric tables, plotting, property plots, and master panels for debugging. A single effect water/LiBr absorption system is used as a case study in this paper to illustrate the features, capabilities, and functions of the new ABSIM. This case study was actually an example system available in the old ABSIM. The new version of ABSIM will be continuously developed to include additional subroutines for the components in liquid desiccant systems. The new ABSIM will be available to public for free. The ultimate goal of the new ABSIM is to allow it to become a simulation

  10. An update to the Greig Health Record: Executive summary.

    PubMed

    Greig, Anita Arya; Constantin, Evelyn; LeBlanc, Claire Ma; Riverin, Bruno; Li, Patricia Tak-Sam; Cummings, Carl

    2016-01-01

    The Greig Health Record is an evidence-based health promotion guide for clinicians caring for children and adolescents 6 to 17 years of age. It provides a template for periodic health visits that is easy to use and adaptable for electronic medical records. On the record, the strength of recommendations is indicated in boldface for good, in italics for fair, and in regular typeface for recommendations based on consensus or inconclusive evidence. Checklist templates include sections for Weight, Height and BMI, Psychosocial history and Development, Nutrition, Education and Advice, Specific Concerns, Examination, Assessment, Immunization, and Medications. Included with the checklist tables are five pages of selected guidelines and resources. This update includes information from recent guidelines and research in preventive care for children and adolescents 6 to 17 years of age. Regular updates are planned. The complete Greig Health Record can be found online at the Canadian Paediatric Society's website: www.cps.ca.

  11. An update to the Greig Health Record: Executive summary

    PubMed Central

    Greig, Anita Arya; Constantin, Evelyn; LeBlanc, Claire MA; Riverin, Bruno; Li, Patricia Tak-Sam; Cummings, Carl

    2016-01-01

    The Greig Health Record is an evidence-based health promotion guide for clinicians caring for children and adolescents 6 to 17 years of age. It provides a template for periodic health visits that is easy to use and adaptable for electronic medical records. On the record, the strength of recommendations is indicated in boldface for good, in italics for fair, and in regular typeface for recommendations based on consensus or inconclusive evidence. Checklist templates include sections for Weight, Height and BMI, Psychosocial history and Development, Nutrition, Education and Advice, Specific Concerns, Examination, Assessment, Immunization, and Medications. Included with the checklist tables are five pages of selected guidelines and resources. This update includes information from recent guidelines and research in preventive care for children and adolescents 6 to 17 years of age. Regular updates are planned. The complete Greig Health Record can be found online at the Canadian Paediatric Society’s website: www.cps.ca. PMID:27441024

  12. Air-quality-model update

    SciTech Connect

    Penner, J.E.; Walton, J.J.

    1982-01-15

    The Livermore Regional Air Quality Model (LIRAQ) has been updated and improved. This report describes the changes that have been made in chemistry, species treatment, and boundary conditions. The results of smog chamber simulations that were used to verify the chemistry as well as simulations of the entire air quality model for two prototype days in the Bay Area are reported. The results for the prototype day simulations are preliminary due to the need for improvement in meteorology fields, but they show the dependence and sensitivity of high hour ozone to changes in selected boundary and initial conditions.

  13. Cerebral Palsy: A Dental Update

    PubMed Central

    Sehrawat, Nidhi; Bansal, Kalpana; Chopra, Radhika

    2014-01-01

    ABSTRACT Special and medically compromised patients present a unique population that challenges the dentist’s skill and knowledge. Providing oral care to people with cerebral palsy (CP) requires adaptation of the skills we use everyday. In fact, most people with mild or moderate forms of CP can be treated successfully in the general practice setting. This article is to review various dental considerations and management of a CP patient. How to cite this article: Sehrawat N, Marwaha M, Bansal K, Chopra R. Cerebral Palsy: A Dental Update. Int J Clin Pediatr Dent 2014;7(2):109-118. PMID:25356010

  14. The hyperactive child: an update.

    PubMed

    Myers, D A; Claman, L; Oldham, D G; Waller, D A; Crumley, F E; Hebeler, J R; Pearson, G T; Shadid, L G

    1989-03-01

    The physician is uniquely qualified to manage the multiple facets of attention-deficit hyperactivity disorder. This clinically oriented update reviews the current state of the art regarding diagnosis and management of hyperactive children. Three case reports emphasize the wide variation of clinical problems presented by this frequently occurring disorder of childhood. Epidemiology, differential diagnosis, associated features, neurobiologic mechanisms, treatment, long-term outcome, and attention-deficit disorder in adults are addressed. Although medication is an important tool in the treatment of this condition, follow-up studies confirm the importance of a multimodal treatment approach.

  15. [Vaccinations in dentistry. An update].

    PubMed

    2015-01-01

    The purpose of this current paper is to give a simple update and overview about vaccinations for dental health care workers considering the new guidelines published in February 2014 by the Swiss Federal Office of Public Health. It is recommended to have at least a valid protection against hepatitis B, measles, mumps, rubella, influenza, varicella, diphtheria, tetanus, poliomyelitis and pertussis. Dental health care workers are highly exposed and high risk carriers for inoculable diseases, therefore regular refreshment of vaccinations is necessary for public health and their own health.

  16. Big bang nucleosynthesis: An update

    SciTech Connect

    Olive, Keith A.

    2013-07-23

    An update on the standard model of big bang nucleosynthesis (BBN) is presented. With the value of the baryon-tophoton ratio determined to high precision by WMAP, standard BBN is a parameter-free theory. In this context, the theoretical prediction for the abundances of D, {sup 4}He, and {sup 7}Li is discussed and compared to their observational determination. While concordance for D and {sup 4}He is satisfactory, the prediction for {sup 7}Li exceeds the observational determination by a factor of about four. Possible solutions to this problem are discussed.

  17. ISS Update: Burning and Suppression of Solids

    NASA Video Gallery

    ISS Update Commentator Pat Ryan interviews Paul Ferkul, Principal Investigator for the Burning and Suppression of Solids (BASS) experiment, about performing combustion experiments in microgravity. ...

  18. Specifications for updating USGS land use and land cover maps

    USGS Publications Warehouse

    Milazzo, Valerie A.

    1983-01-01

    To meet the increasing demands for up-to-date land use and land cover information, a primary goal of the U.S. Geological Survey's (USGS) national land use and land cover mapping program is to provide for periodic updating of maps and data in a timely and uniform manner. The technical specifications for updating existing USGS land use and land cover maps that are presented here cover both the interpretive aspects of detecting and identifying land use and land cover changes and the cartographic aspects of mapping and presenting the change data in conventional map format. They provide the map compiler with the procedures and techniques necessary to then use these change data to update existing land use and land cover maps in a manner that is both standardized and repeatable. Included are specifications for the acquisition of remotely sensed source materials, selection of compilation map bases, handling of data base corrections, editing and quality control operations, generation of map update products for USGS open file, and the reproduction and distribution of open file materials. These specifications are planned to become part of the National Mapping Division's Technical Instructions.

  19. Risk Assessment Update: Russian Segment

    NASA Technical Reports Server (NTRS)

    Christiansen, Eric; Lear, Dana; Hyde, James; Bjorkman, Michael; Hoffman, Kevin

    2012-01-01

    BUMPER-II version 1.95j source code was provided to RSC-E- and Khrunichev at January 2012 MMOD TIM in Moscow. MEMCxP and ORDEM 3.0 environments implemented as external data files. NASA provided a sample ORDEM 3.0 g."key" & "daf" environment file set for demonstration and benchmarking BUMPER -II v1.95j installation at the Jan-12 TIM. ORDEM 3.0 has been completed and is currently in beta testing. NASA will provide a preliminary set of ORDEM 3.0 ".key" & ".daf" environment files for the years 2012 through 2028. Bumper output files produced using the new ORDEM 3.0 data files are intended for internal use only, not for requirements verification. Output files will contain these words ORDEM FILE DESCRIPTION = PRELIMINARY VERSION: not for production. The projectile density term in many BUMPER-II ballistic limit equations will need to be updated. Cube demo scripts and output files delivered at the Jan-12 TIM have been updated for the new ORDEM 3.0 data files. Risk assessment results based on ORDEM 3.0 and MEM will be presented for the Russian Segment (RS) of ISS.

  20. Urticaria: an evidence-based update. Conference report.

    PubMed

    Alexandroff, A B; Harman, K E

    2010-08-01

    Summary Evidence-based update meetings are held annually by the Centre of Evidence Based Dermatology, University of Nottingham. Topics are chosen by delegates at the previous year's conference and in the past have included blistering disorders, psoriasis, hair disorders and skin cancers. Once the topic is identified, a trials database search is undertaken with the aim of including speakers who are actively involved in trials that address the subject in question. This year, the eighth Evidence Based Update meeting focused on urticaria and took place in Loughborough University on 14 May 2009. The latest data on the diagnosis and management of acute and chronic urticaria, including cold and solar urticaria, and the impact of food intolerance on chronic urticaria, were presented by an international panel of renowned speakers, who sometimes expressed different viewpoints. The highlights of the meeting included an informal atmosphere, an international perspective, and a practical question and answer session. Over 70% of the delegates stated that they would be changing their clinical practice following on from the meeting. The evidence-based update meeting in 2010 will be devoted to eczema.

  1. State-level Greenhouse Gas Emission Factors for Electricity Generation, Updated

    EIA Publications

    2001-01-01

    To assist reporters in estimating emissions and emission reductions, The Energy Information Administration (EIA) has made available in the instructions to Forms EIA-1605 and EIA-1605EZ emission coefficients for most commonly used fossil fuels and electricity. These coefficients were based on 1992 emissions and generation data. In 1999, updated coefficients were prepared based on the most recent data (1998) then available; however, the updated coefficients were not included in the instructions for the 1999 data year. This year, they have been updated again, but based on three years worth of data (1997, 1998, and 1999) rather than a single year.

  2. UCbase 2.0: ultraconserved sequences database (2014 update).

    PubMed

    Lomonaco, Vincenzo; Martoglia, Riccardo; Mandreoli, Federica; Anderlucci, Laura; Emmett, Warren; Bicciato, Silvio; Taccioli, Cristian

    2014-01-01

    UCbase 2.0 (http://ucbase.unimore.it) is an update, extension and evolution of UCbase, a Web tool dedicated to the analysis of ultraconserved sequences (UCRs). UCRs are 481 sequences >200 bases sharing 100% identity among human, mouse and rat genomes. They are frequently located in genomic regions known to be involved in cancer or differentially expressed in human leukemias and carcinomas. UCbase 2.0 is a platform-independent Web resource that includes the updated version of the human genome annotation (hg19), information linking disorders to chromosomal coordinates based on the Systematized Nomenclature of Medicine classification, a query tool to search for Single Nucleotide Polymorphisms (SNPs) and a new text box to directly interrogate the database using a MySQL interface. To facilitate the interactive visual interpretation of UCR chromosomal positioning, UCbase 2.0 now includes a graph visualization interface directly linked to UCSC genome browser. Database URL: http://ucbase.unimore.it.

  3. Clinical practice guideline (update): Adult Sinusitis Executive Summary.

    PubMed

    Rosenfeld, Richard M; Piccirillo, Jay F; Chandrasekhar, Sujana S; Brook, Itzhak; Kumar, Kaparaboyna Ashok; Kramper, Maggie; Orlandi, Richard R; Palmer, James N; Patel, Zara M; Peters, Anju; Walsh, Sandra A; Corrigan, Maureen D

    2015-04-01

    The American Academy of Otolaryngology-Head and Neck Surgery Foundation has published a supplement to this issue featuring the updated "Clinical Practice Guideline: Adult Sinusitis" as a supplement to Otolaryngology-Head and Neck Surgery. To assist in implementing the guideline recommendations, this article summarizes the rationale, purpose, and key action statements. The 14 developed recommendations address diagnostic accuracy for adult rhinosinusitis, the appropriate use of ancillary tests to confirm diagnosis and guide management (including radiography, nasal endoscopy, computed tomography, and testing for allergy and immune function), and the judicious use of systemic and topical therapy. Emphasis was also placed on identifying multiple chronic conditions that would modify management of rhinosinusitis, including asthma, cystic fibrosis, immunocompromised state, and ciliary dyskinesia. An updated guideline is needed as a result of new clinical trials, new systematic reviews, and the lack of consumer participation in the initial guideline development group.

  4. Sources of information on postgraduate medical training programs - 2004 update.

    PubMed

    Brazin, Lillian R

    2004-01-01

    This is the biennial update listing directories, journal articles, Web sites, and general books that aid the librarian, house officer, or medical student in finding information on medical residency and fellowship programs. The World Wide Web provides the most current and complete source of information about postgraduate training programs and specialties. This update goes beyond postgraduate training resources to include selected Web sites and books on resume writing, practice management, personal financial issues, the "Match," exam preparation, job hunting, and the DEA license application process. Print resources are included if they provide information not on the Internet or have features that are particularly useful. The Internet continues to be a major marketing tool for hospitals seeking to recruit the best and brightest for their residency and fellowship programs. Even the smallest community hospital usually has a presence on the 'Net.

  5. Better Plants Progress Update Fall 2013

    SciTech Connect

    none,

    2013-09-23

    This Progress Update summarizes the significant energy saving achievements and cumulative cost savings made by these industry leaders from 2010-2012. The update also shares the plans and priorities over the next year for the Better Plants Program to continue to advance energy efficiency in the industrial sector.

  6. 1 CFR 8.3 - Periodic updating.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Periodic updating. 8.3 Section 8.3 General... the intent and purpose of the Administrative Committee as stated in § 8.1. (b) Staggered publication... before the “As of” date. Thus, each title updated as of July 1 each year will reflect all...

  7. 1 CFR 8.3 - Periodic updating.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Periodic updating. 8.3 Section 8.3 General... the intent and purpose of the Administrative Committee as stated in § 8.1. (b) Staggered publication... before the “As of” date. Thus, each title updated as of July 1 each year will reflect all...

  8. 40 CFR 55.12 - Consistency updates.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 5 2011-07-01 2011-07-01 false Consistency updates. 55.12 Section 55.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) OUTER CONTINENTAL SHELF AIR REGULATIONS § 55.12 Consistency updates. (a) The Administrator will...

  9. Census in Schools Educator Update, June 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census; (2)…

  10. Census in Schools Educator Update, May 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census: The…

  11. 75 FR 39629 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to 10 CFR 1703.107(b)(6) of the Board's regulations....

  12. 77 FR 41258 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to the Board's...

  13. 76 FR 43819 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to the Board's...

  14. Census in Schools Educator Update, November 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) New Web Site for the…

  15. Census in Schools Educator Update, February 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census Video: A…

  16. Census in Schools Educator Update, October 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) Census in Schools…

  17. Census in Schools Educator Update, September 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) Census in Schools is…

  18. Census in Schools Educator Update, January 2010

    ERIC Educational Resources Information Center

    US Census Bureau, 2010

    2010-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census; (2)…

  19. Census in Schools Educator Update, April 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census; (2)…

  20. Census in Schools Educator Update, March 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1)…

  1. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  2. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  3. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  4. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  5. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  6. Control of Interference during Working Memory Updating

    ERIC Educational Resources Information Center

    Szmalec, Arnaud; Verbruggen, Frederick; Vandierendonck, Andre; Kemps, Eva

    2011-01-01

    The current study examined the nature of the processes underlying working memory updating. In 4 experiments using the n-back paradigm, the authors demonstrate that continuous updating of items in working memory prevents strong binding of those items to their contexts in working memory, and hence leads to an increased susceptibility to proactive…

  7. Colorectal Cancer in African Americans: An Update

    PubMed Central

    Williams, Renee; White, Pascale; Nieto, Jose; Vieira, Dorice; Francois, Fritz; Hamilton, Frank

    2016-01-01

    This review is an update to the American College of Gastroenterology (ACG) Committee on Minority Affairs and Cultural Diversity's paper on colorectal cancer (CRC) in African Americans published in 2005. Over the past 10 years, the incidence and mortality rates of CRC in the United States has steadily declined. However, reductions have been strikingly much slower among African Americans who continue to have the highest rate of mortality and lowest survival when compared with all other racial groups. The reasons for the health disparities are multifactorial and encompass physician and patient barriers. Patient factors that contribute to disparities include poor knowledge of benefits of CRC screening, limited access to health care, insurance status along with fear and anxiety. Physician factors include lack of knowledge of screening guidelines along with disparate recommendations for screening. Earlier screening has been recommended as an effective strategy to decrease observed disparities; currently the ACG and American Society of Gastrointestinal Endoscopists recommend CRC screening in African Americans to begin at age 45. Despite the decline in CRC deaths in all racial and ethnic groups, there still exists a significant burden of CRC in African Americans, thus other strategies including educational outreach for health care providers and patients and the utilization of patient navigation systems emphasizing the importance of screening are necessary. These strategies have been piloted in both local communities and Statewide resulting in notable significant decreases in observed disparities. PMID:27467183

  8. The UCSC Genome Browser database: 2014 update

    PubMed Central

    Karolchik, Donna; Barber, Galt P.; Casper, Jonathan; Clawson, Hiram; Cline, Melissa S.; Diekhans, Mark; Dreszer, Timothy R.; Fujita, Pauline A.; Guruvadoo, Luvina; Haeussler, Maximilian; Harte, Rachel A.; Heitner, Steve; Hinrichs, Angie S.; Learned, Katrina; Lee, Brian T.; Li, Chin H.; Raney, Brian J.; Rhead, Brooke; Rosenbloom, Kate R.; Sloan, Cricket A.; Speir, Matthew L.; Zweig, Ann S.; Haussler, David; Kuhn, Robert M.; Kent, W. James

    2014-01-01

    The University of California Santa Cruz (UCSC) Genome Browser (http://genome.ucsc.edu) offers online public access to a growing database of genomic sequence and annotations for a large collection of organisms, primarily vertebrates, with an emphasis on the human and mouse genomes. The Browser’s web-based tools provide an integrated environment for visualizing, comparing, analysing and sharing both publicly available and user-generated genomic data sets. As of September 2013, the database contained genomic sequence and a basic set of annotation ‘tracks’ for ∼90 organisms. Significant new annotations include a 60-species multiple alignment conservation track on the mouse, updated UCSC Genes tracks for human and mouse, and several new sets of variation and ENCODE data. New software tools include a Variant Annotation Integrator that returns predicted functional effects of a set of variants uploaded as a custom track, an extension to UCSC Genes that displays haplotype alleles for protein-coding genes and an expansion of data hubs that includes the capability to display remotely hosted user-provided assembly sequence in addition to annotation data. To improve European access, we have added a Genome Browser mirror (http://genome-euro.ucsc.edu) hosted at Bielefeld University in Germany. PMID:24270787

  9. Gramene database in 2010: updates and extensions.

    PubMed

    Youens-Clark, Ken; Buckler, Ed; Casstevens, Terry; Chen, Charles; Declerck, Genevieve; Derwent, Paul; Dharmawardhana, Palitha; Jaiswal, Pankaj; Kersey, Paul; Karthikeyan, A S; Lu, Jerry; McCouch, Susan R; Ren, Liya; Spooner, William; Stein, Joshua C; Thomason, Jim; Wei, Sharon; Ware, Doreen

    2011-01-01

    Now in its 10th year, the Gramene database (http://www.gramene.org) has grown from its primary focus on rice, the first fully-sequenced grass genome, to become a resource for major model and crop plants including Arabidopsis, Brachypodium, maize, sorghum, poplar and grape in addition to several species of rice. Gramene began with the addition of an Ensembl genome browser and has expanded in the last decade to become a robust resource for plant genomics hosting a wide array of data sets including quantitative trait loci (QTL), metabolic pathways, genetic diversity, genes, proteins, germplasm, literature, ontologies and a fully-structured markers and sequences database integrated with genome browsers and maps from various published studies (genetic, physical, bin, etc.). In addition, Gramene now hosts a variety of web services including a Distributed Annotation Server (DAS), BLAST and a public MySQL database. Twice a year, Gramene releases a major build of the database and makes interim releases to correct errors or to make important updates to software and/or data.

  10. The UCSC Genome Browser database: 2014 update.

    PubMed

    Karolchik, Donna; Barber, Galt P; Casper, Jonathan; Clawson, Hiram; Cline, Melissa S; Diekhans, Mark; Dreszer, Timothy R; Fujita, Pauline A; Guruvadoo, Luvina; Haeussler, Maximilian; Harte, Rachel A; Heitner, Steve; Hinrichs, Angie S; Learned, Katrina; Lee, Brian T; Li, Chin H; Raney, Brian J; Rhead, Brooke; Rosenbloom, Kate R; Sloan, Cricket A; Speir, Matthew L; Zweig, Ann S; Haussler, David; Kuhn, Robert M; Kent, W James

    2014-01-01

    The University of California Santa Cruz (UCSC) Genome Browser (http://genome.ucsc.edu) offers online public access to a growing database of genomic sequence and annotations for a large collection of organisms, primarily vertebrates, with an emphasis on the human and mouse genomes. The Browser's web-based tools provide an integrated environment for visualizing, comparing, analysing and sharing both publicly available and user-generated genomic data sets. As of September 2013, the database contained genomic sequence and a basic set of annotation 'tracks' for ∼90 organisms. Significant new annotations include a 60-species multiple alignment conservation track on the mouse, updated UCSC Genes tracks for human and mouse, and several new sets of variation and ENCODE data. New software tools include a Variant Annotation Integrator that returns predicted functional effects of a set of variants uploaded as a custom track, an extension to UCSC Genes that displays haplotype alleles for protein-coding genes and an expansion of data hubs that includes the capability to display remotely hosted user-provided assembly sequence in addition to annotation data. To improve European access, we have added a Genome Browser mirror (http://genome-euro.ucsc.edu) hosted at Bielefeld University in Germany.

  11. Background Information Document for Updating AP42 Section 2.4 for Estimating Emissions from Municipal Solid Waste Landfills

    EPA Science Inventory

    This revised draft document was prepared for U.S. EPA's Office of Research and Development, and describes the data analysis undertaken to update the Municipal Solid Waste (MSW) Landfill section of AP-42. This 2008 update includes the addition of data from 62 landfill gas emission...

  12. AYP Results for 2010-11--May 2012 Update

    ERIC Educational Resources Information Center

    Usher, Alexandra

    2012-01-01

    This report updates the December, 2011 report "AYP Results for 2010-11" to include AYP data from school year 2010-11 for New York State. Several numbers throughout the report have changed as a result of the new data from New York. Most notably, the estimated percentage of all public schools in the nation that did not make AYP for 2011 has been…

  13. MODEL UPDATING: TRANSITION FROM RESEARCH TO PRACTICE?

    SciTech Connect

    D. C. ZIMMERMAN; F. M. HEMEZ

    2000-10-01

    This session offers an open forum to discuss issues associated with the transition of nearly two decades of engineering research into computational guided model updating into industry state-of-the-practice. Related technical issues are the model updating technology, model reduction, test-analysis correlation and optimization strategies. The session is organized as follows. Technical presentations review the state-of-the-art in finite element model updating and present examples of industrial applications. The results of a recent survey on the potential and usefulness of the model updating technology are discussed. Panel discussions and interaction with the audience discuss industrial needs, future trends and challenges and why negative model updating results are never discussed within the structural dynamics community.

  14. Protocol independent adaptive route update for VANET.

    PubMed

    Rasheed, Asim; Ajmal, Sana; Qayyum, Amir

    2014-01-01

    High relative node velocity and high active node density have presented challenges to existing routing approaches within highly scaled ad hoc wireless networks, such as Vehicular Ad hoc Networks (VANET). Efficient routing requires finding optimum route with minimum delay, updating it on availability of a better one, and repairing it on link breakages. Current routing protocols are generally focused on finding and maintaining an efficient route, with very less emphasis on route update. Adaptive route update usually becomes impractical for dense networks due to large routing overheads. This paper presents an adaptive route update approach which can provide solution for any baseline routing protocol. The proposed adaptation eliminates the classification of reactive and proactive by categorizing them as logical conditions to find and update the route.

  15. Protocol Independent Adaptive Route Update for VANET

    PubMed Central

    Rasheed, Asim; Qayyum, Amir

    2014-01-01

    High relative node velocity and high active node density have presented challenges to existing routing approaches within highly scaled ad hoc wireless networks, such as Vehicular Ad hoc Networks (VANET). Efficient routing requires finding optimum route with minimum delay, updating it on availability of a better one, and repairing it on link breakages. Current routing protocols are generally focused on finding and maintaining an efficient route, with very less emphasis on route update. Adaptive route update usually becomes impractical for dense networks due to large routing overheads. This paper presents an adaptive route update approach which can provide solution for any baseline routing protocol. The proposed adaptation eliminates the classification of reactive and proactive by categorizing them as logical conditions to find and update the route. PMID:24723807

  16. Heart Disease and Stroke Statistics—2011 Update

    PubMed Central

    Roger, Véronique L.; Go, Alan S.; Lloyd-Jones, Donald M.; Adams, Robert J.; Berry, Jarett D.; Brown, Todd M.; Carnethon, Mercedes R.; Dai, Shifan; de Simone, Giovanni; Ford, Earl S.; Fox, Caroline S.; Fullerton, Heather J.; Gillespie, Cathleen; Greenlund, Kurt J.; Hailpern, Susan M.; Heit, John A.; Ho, P. Michael; Howard, Virginia J.; Kissela, Brett M.; Kittner, Steven J.; Lackland, Daniel T.; Lichtman, Judith H.; Lisabeth, Lynda D.; Makuc, Diane M.; Marcus, Gregory M.; Marelli, Ariane; Matchar, David B.; McDermott, Mary M.; Meigs, James B.; Moy, Claudia S.; Mozaffarian, Dariush; Mussolino, Michael E.; Nichol, Graham; Paynter, Nina P.; Rosamond, Wayne D.; Sorlie, Paul D.; Stafford, Randall S.; Turan, Tanya N.; Turner, Melanie B.; Wong, Nathan D.; Wylie-Rosett, Judith

    2015-01-01

    Summary Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update. The Statistical Update is a valuable resource for researchers, clinicians, healthcare policy makers, media professionals, the lay public, and many others who seek the best national data available on disease morbidity and mortality and the risks, quality of care, medical procedures and operations, and costs associated with the management of these diseases in a single document. Indeed, since 1999, the Statistical Update has been cited more than 8700 times in the literature (including citations of all annual versions). In 2009 alone, the various Statistical Updates were cited ≈1600 times (data from ISI Web of Science). In recent years, the Statistical Update has undergone some major changes with the addition of new chapters and major updates across multiple areas. For this year’s edition, the Statistics Committee, which produces the document for the AHA, updated all of the current chapters with the most recent nationally representative data and inclusion of relevant articles from the literature over the past year and added a new chapter detailing how family history and genetics play a role in cardiovascular disease (CVD) risk. Also, the 2011 Statistical Update is a major source for monitoring both cardiovascular health and disease in the population, with a focus on progress toward achievement of the AHA’s 2020 Impact Goals. Below are a few highlights from this year’s Update. Death Rates From CVD Have Declined, Yet the Burden of Disease Remains High The 2007 overall death rate from CVD (International Classification of Diseases 10, I00–I99) was 251.2 per 100 000. The rates were 294

  17. Updating national standards for drinking-water: a Philippine experience.

    PubMed

    Lomboy, M; Riego de Dios, J; Magtibay, B; Quizon, R; Molina, V; Fadrilan-Camacho, V; See, J; Enoveso, A; Barbosa, L; Agravante, A

    2017-04-01

    The latest version of the Philippine National Standards for Drinking-Water (PNSDW) was issued in 2007 by the Department of Health (DOH). Due to several issues and concerns, the DOH decided to make an update which is relevant and necessary to meet the needs of the stakeholders. As an output, the water quality parameters are now categorized into mandatory, primary, and secondary. The ten mandatory parameters are core parameters which all water service providers nationwide are obligated to test. These include thermotolerant coliforms or Escherichia coli, arsenic, cadmium, lead, nitrate, color, turbidity, pH, total dissolved solids, and disinfectant residual. The 55 primary parameters are site-specific and can be adopted as enforceable parameters when developing new water sources or when the existing source is at high risk of contamination. The 11 secondary parameters include operational parameters and those that affect the esthetic quality of drinking-water. In addition, the updated PNSDW include new sections: (1) reporting and interpretation of results and corrective actions; (2) emergency drinking-water parameters; (3) proposed Sustainable Development Goal parameters; and (4) standards for other drinking-water sources. The lessons learned and insights gained from the updating of standards are likewise incorporated in this paper.

  18. Update in pulmonary arterial hypertension.

    PubMed

    Mejía Chew, C R; Alcolea Batres, S; Ríos Blanco, J J

    2016-11-01

    Pulmonary arterial hypertension is a rare and progressive disease that mainly affects the pulmonary arterioles (precapillary), regardless of the triggering aetiology. The prevalence of pulmonary hypertension and pulmonary arterial hypertension in Spain is estimated at 19.2 and 16 cases per million inhabitants, respectively. The diagnosis of pulmonary arterial hypertension is based on haemodynamic criteria (mean pulmonary artery pressure ≥25mmHg, pulmonary capillary wedge pressure ≤15mmHg and pulmonary vascular resistance >3 Wood units) and therefore requires the implementation of right cardiac catheterisation. Sequential therapy with a single drug has been used in clinical practice. However, recent European guidelines recommend combined initial therapy in some situations. This review conducts a critical update of our knowledge of this disease according to the latest guidelines and recommendations.

  19. [An update on Lassa virus].

    PubMed

    Leparc-Goffart, I; Emonet, S F

    2011-12-01

    Lassa virus, the etiologic agent of Lassa hemorrhagic fever, infects 100,000 to 300,000 people every year in West Africa with an overall mortality rate ranging from 1 to 2%. It was discovered in 1969 and remains a significant public health risk in endemic areas. Because airborne transmission is possible and mortality can be high under certain conditions, Lassa virus has been classified as a category A bioterrorism agent. Early diagnosis is difficult due to insidious non-specific onset and to the great genetic divergence of the virus that makes RT-PCR assays unreliable. The lack of proper diagnostic tools promotes nosocomial infection and diminishes the efficacy of treatment. Recently, numerous advances have been made in the development of both diagnostic and vaccination techniques. The purpose of this review is to present an update on that research as well as the current epidemiology of Lassa virus.

  20. The AGTSR consortium: An update

    SciTech Connect

    Fant, D.B.; Golan, L.P.

    1995-12-31

    The Advanced Gas Turbine Systems Research program is a nationwide consortium dedicated to advancing land-based gas turbine systems for improving future power generation capability. It directly supports the technology-research arm of the ATS program and targets industry- defined research needs in the areas of combustion, heat transfer, materials, aerodynamics, controls, alternative fuels, and advanced cycles. It is organized to enhance U.S. competitiveness through close collaboration with universities, government, and industry at the R&D level. AGTSR is just finishing its third year of operation; it is scheduled to continue past the year 2000. This update reviews the AGTSR triad, which consists of university/industry R&D activities, technology transfer programs, and trial student programs.