Science.gov

Sample records for 51-l updates included

  1. Atmospheric environment for space shuttle (STS-51L) launch

    NASA Technical Reports Server (NTRS)

    Jasper, G. L.; Johnson, D. L.; Alexander, M.; Fichtl, G. H.; Batts, G. W.

    1986-01-01

    A summary is given of selected atmospheric conditions observed near Space Shuttle STS-51L launch time on January 28, 1986, at Kennedy Space Center, Florida. Values of ambient pressure, temperature, moisture, ground winds, visual observations (cloud), and winds aloft are included. The sequence of pre-launch Jimsphere measured vertical wind profiles is given. The final atmospheric tape, which consists of wind and thermodynamic parameters versus altitude, for STS-51L vehicle ascent has been constructed. The STS-51L ascent atmospheric data tape has been constructed by Marshall Space Flight Center's Atmospheric Sciences Division to provide an internally consistent data set for use in post flight performance assessments.

  2. 51-L Flight Crew Emergency Egress Training

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The STS-51L Challenger flight crew emergency egress training in the slide wire baskets. From left to right they are: Mission Specialist, Ronald McNair, Payload Specialist, Gregory Jarvis, Teacher in Space Participant, Christa McAuliffe. Directly behind them: Mission Specialist Judy Resnik and Mission Specialist, Ellison Onizuka.

  3. View of the SRB recovery during STS 51-L investigation

    NASA Technical Reports Server (NTRS)

    1986-01-01

    View of the solid rocket boosters (SRB) recovery during STS 51-L investigation. Photos include school of fish swimming by portion of the SRB. Kennedy Space Center (KSC) alternative photo number is 108-KSC-386C-1921/3 (30363); Portion of the SRB is lowered onto the deck of the recovery ship. KSC alternative photo number is 108-KSC-386C-923/3 (30364).

  4. View of the SRB recovery during STS 51-L investigation

    NASA Technical Reports Server (NTRS)

    1986-01-01

    View of the solid rocket boosters (SRB) recovery during STS 51-L investigation. Photos include portion of the SRB against a black background. The Kennedy Space Center (KSC) alternate photo number is 108-KSC-386C-1923/6 (29994); A man on the recovery ship hoses down a piece of the SRB. The KSC alternative photo number is 108-KSC-386C-1922/3 (29995); Deep drone contact with a portion of the SRB. KSC alternative photo number is 108-KSC-386C-937/12 (29996); School of fish swim by portion of the SRB. KSC alternative photo number is 108-KSC-386C-937/18 (29997).

  5. View of the SRB recovery during STS 51-L investigation

    NASA Technical Reports Server (NTRS)

    1986-01-01

    View of the solid rocket boosters (SRB) recovery during STS 51-L investigation. Photos include close-up view of portion of SRB. Kennedy Space Center (KSC) alternative photo number is 108-KSC-386C-938/7 (29888); Another close-up view of portion of SRB. KSC alternative photo number is 108-KSC-386C-938/14 (29889); Stena Workhorse arrival and offload of SRB at Trident Basin. KSC alternative photo number is 108-KSC-386C-938/6 (29890). photo number is 108-KSC-386C-937/12 (29996); School of fish swim by portion of the SRB. KSC alternative photo number is 108-KSC-386C-937/18 (29997).

  6. President Ronald Reagan speaks at STS 51-L Memorial service

    NASA Technical Reports Server (NTRS)

    1986-01-01

    President Ronald Reagan tells a large turnout of JSC employees and family and friends of the 51-L crewmembers about their accomplishments and sacrifices during memorial services held following the Challenger accident at Kennedy Space Center (KSC).'They slipped the surly bonds of earth to touch the face of God' the President told the thousands gathered on the central mall at JSC.

  7. The International Project. 1992 Update. Including "Microfilming Projects Abroad."

    ERIC Educational Resources Information Center

    Rutimann, Hans

    This publication describes national and international book preservation programs, including: (l) the European Register of Microform Masters (EROMM), a cooperative effort in which the Commission on Preservation and Access is a partner; (2) national preservation programs in Germany, France, Ireland, Britain, Netherlands, Sweden, China, and Central…

  8. Practical uses for ecdysteroids in mammals including humans: an update

    PubMed Central

    Lafont, R.; Dinan, L.

    2003-01-01

    Ecdysteroids are widely used as inducers for gene-switch systems based on insect ecdysteroid receptors and genes of interest placed under the control of ecdysteroid-response elements. We review here these systems, which are currently mainly used in vitro with cultured cells in order to analyse the role of a wide array of genes, but which are expected to represent the basis for future gene therapy strategies. Such developments raise several questions, which are addressed in detail. First, the metabolic fate of ecdysteroids in mammals, including humans, is only poorly known, and the rapid catabolism of ecdysteroids may impede their use as in vivo inducers. A second set of questions arose in fact much earlier with the pioneering “heterophylic” studies of Burdette in the early sixties on the pharmacological effects of ecdysteroids on mammals. These and subsequent studies showed a wide range of effects, most of them being beneficial for the organism (e.g. hypoglycaemic, hypocholesterolaemic, anabolic). These effects are reviewed and critically analysed, and some hypotheses are proposed to explain the putative mechanisms involved. All of these pharmacological effects have led to the development of a wide array of ecdysteroid-containing preparations, which are primarily used for their anabolic and/or “adaptogenic” properties on humans (or horses or dogs). In the same way, increasing numbers of patents have been deposited concerning various beneficial effects of ecdysteroids in many medical or cosmetic domains, which make ecdysteroids very attractive candidates for several practical uses. It may be questioned whether all these pharmacological actions are compatible with the development of ecdysteroid-inducible gene switches for gene therapy, and also if ecdysteroids should be classified among doping substances. Abbreviation: 20E 20-hydroxyecdysone 2d20E 2-deoxy-20-hydroxyecdysone 2dE 2-deoxyecdysone BAH bisacylhydrazine BmEcR Bombyx mori EcR CfEcR Choristoneura

  9. Wreckage from the Shuttle mission 51-L mission retrieved from the Atlantic

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Wreckage from the Space Shuttle mission 51-L mission retrieved from the Atlantic Ocean by a flotilla of U.S. Coast Guard and U.S. Navy vessels was returned to the Trident Basin at Cape Canaveral Air Force Station aboard the U.S. Coast Guard cutter Dallas. Views include portion of the side hatch area on the crew compartment (015); views of tile work on portions of the underside of the orbiter (016-19).

  10. STS 51-L crewmembers briefed during training session

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Five members of the STS 51-L crew and a backup crewmember are briefed during a training session in JSC's Shuttle mockup and integration laboratory. From left to right are Astronauts Ellison S. Onizuka, mission specialist; Ronald E. McNair, mission specialist; Gregory Jarvis, Hughes payload specialist; Judith A. Resnik, mission specialist; Sharon Christa McAuliffe, citizen observer/payload specialist representing the Teacher in Space project. Barbara R. Morgan, backup to McAuliffe, is in the right foreground.

  11. A parametric shell analysis of the shuttle 51-L SRB AFT field joint

    NASA Technical Reports Server (NTRS)

    Davis, Randall C.; Bowman, Lynn M.; Hughes, Robert M., IV; Jackson, Brian J.

    1990-01-01

    Following the Shuttle 51-L accident, an investigation was conducted to determine the cause of the failure. Investigators at the Langley Research Center focused attention on the structural behavior of the field joints with O-ring seals in the steel solid rocket booster (SRB) cases. The shell-of-revolution computer program BOSOR4 was used to model the aft field joint of the solid rocket booster case. The shell model consisted of the SRB wall and joint geometry present during the Shuttle 51-L flight. A parametric study of the joint was performed on the geometry, including joint clearances, contact between the joint components, and on the loads, induced and applied. In addition combinations of geometry and loads were evaluated. The analytical results from the parametric study showed that contact between the joint components was a primary contributor to allowing hot gases to blow by the O-rings. Based upon understanding the original joint behavior, various proposed joint modifications are shown and analyzed in order to provide additional insight and information. Finally, experimental results from a hydro-static pressurization of a test rocket booster case to study joint motion are presented and verified analytically.

  12. STS 51-L Memorial Montage designed by Bill Corey of TGS

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The STS 51-L Memorial Montage designed by Bill Corey of TGS Technology. The montage contains portraits of each of the STS 51-L crewmembers, a view of the Challenger at liftoff, the mission patch and a statement which reads 'They slipped the surly bonds of earth to touch the face of God'. At the end of the statement is a bird flying.

  13. Operational Dataset Update Functionality Included in the NCAR Research Data Archive Management System

    NASA Astrophysics Data System (ADS)

    Ji, Z.; Worley, S. J.; Schuster, D. C.

    2011-12-01

    Growing complexity, volume, and reliance on operationally created datasets poses challenges to the centers tasked with archiving and curating this information. Past tools focused on data delivered via media, such as tape, or data downloaded by single dataset customized ftp scripting. Presently nearly all data are acquired via network interactions, which can happen many times per day. Prior archive management technologies do not scale to this new paradigm. The Research Data Archive Management System (RDAMS) was developed to meet this challenge and has been implemented to support archive management within the Research Data Archive (RDA) at the National Center for Atmospheric Research (NCAR). RDAMS is driven by open source based databases and utilities, and is designed to support the complete data archive cycle by fetching, interrogating, archiving, and providing long-term research data stewardship. A good example of RDAMS functionality is found in the utility developed to specifically manage operational dataset updates, and can be applied to any dataset that requires periodic updating. The RDAMS dataset update utility (DSUPDT) accomplishes four basic tasks: 1) contact and query a remote server to see if new or modified data are available, 2) move data from a remote host to a local system and verify data transfer integrity, 3) execute any required data processing steps including metadata harvesting, 4) archive data to local disk and backup media systems. To accomplish these tasks across a diverse variety of datasets, DSUPDT incorporates a broad base of functionality. For example, it can be configured to run according to many different data set requirements, handles multiple web protocols, automatically recovers from system outages at the remote or local site, can execute 3rd party data manipulation software, and accommodates irregular data delivery schedules. Currently over 150 RDA dataset products are configured to be under DSUPDT control, with datasets being updated

  14. Signs of black smoke during Liftoff of the Shuttle Challenger STS 51-L

    NASA Technical Reports Server (NTRS)

    1986-01-01

    This 70mm still photograph of the 51-L launch was taken from Camera Pad 10 north of Launch complex 39-B approximately 58.32 seconds after launch. The photograph shows an unusual plume in the lower part of the right hand solid rocket booster (SRB) (026); Photograph of the 51-L launch at approximately 58.82 seconds after launch shows an unusual plume in the lower part of the right hand SRB (027); Photograph of the 51-L launch at approximately 1 minute, 13.14 seconds after launch showing a plume in the lower part of the right hand SRB (028).

  15. Artists concept of the salvage operations offshore of KSC after STS 51-L

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Salvage operations offshore of Kennedy Space Center (KSC) after STS 51-L are depicted in this artist's concept showing a grapple and recovery fixture (left) being directed through the use of a remote video system suspended from the recovery ship.

  16. 77 FR 55439 - Vessel Traffic Service Updates, Including Establishment of Vessel Traffic Service Requirements...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-10

    ...The Coast Guard proposes to revise and update the Vessel Traffic Service (VTS) regulations in 33 CFR part 161. The revision would require participation in the VTS in Port Arthur, Texas, which is now voluntary; consolidate and expand a VTS Special Area in Puget Sound, Washington; update the designated frequencies for the Maritime Mobile Service Identifiers (MMSI) for Louisville and Los......

  17. 77 FR 64076 - Vessel Traffic Service Updates, Including Establishment of Vessel Traffic Service Requirements...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... 10, 2012 (77 FR 55439), which proposes to revise and update the Vessel Traffic Service regulations in..., 2012 (77 FR 55439) for instructions on submitting comments. FOR FURTHER INFORMATION CONTACT: Lieutenant... On September 10, 2012, the Coast Guard published a notice of proposed rulemaking (NPRM) (77 FR...

  18. Payload specialists in training for STS 51-L in mockup and integration lab

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Payload specialists in training for STS 51-L take a break in Shuttle emergency egress training at JSC's mockup and integration laboratory. Left to right are Gregory Jarvis of Hughes, Sharon Christa McAuliffe and Barbara Morgan of the Teacher in Space Project.

  19. Wreckage from the Shuttle mission 51-L mission retrieved from the Atlantic

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Wreckage from the Space Shuttle mission 51-L mission retrieved from the Atlantic Ocean by a flotilla of U.S. Coast Guard and U.S. Navy vessels was returned to the Trident Basin at Cape Canaveral Air Force Station aboard the U.S. Coast Guard cutter Dallas. Views tile work on portions of the underside of the orbiter (020-24); portion of the crew compartment (025).

  20. View of debris assembled at the Kennedy Space Center from STS 51-L

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Pieces of the external tank from the STS 51-L accident are assembled in a tent near the Logistics Facility at the Kennedy Space Center. Most of the pieces were recovered by the Coast Guard and Navy following the accident. The pieces were assembled so that the side which normally would face the Orbiter Challenger is in the center of the tent. The picture was taken from the right side of the rear of the tank facing toward the top.

  1. View of the STS 51-L Memorial service on JSC's main mall

    NASA Technical Reports Server (NTRS)

    1986-01-01

    A wide angle lens was used to capture only a portion of the crowd gathered for memorial services for the seven members of the STS 51-L Challenger crew at JSC. President Ronald Reagan speaks at the lectern at far left edge of the frame. The photographer for the picture was positioned on a large platform erected to accommodate the many members of the news media on hand for the event.

  2. Teacher in Space trainees undergo training for STS 51-L mission

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Teacher in Space trainees undergo training for STS 51-L mission. Sharon Christa McAuliffe, named as prime crew citizen observer, studies the console on the aft flight deck, which contains controls for the remote manipulator system (RMS) and other important functions (40508); Barbara R. Morgan (left), back-up observer, and McAuliffe are briefed by L.W. Lew on the Space Shuttle galley, located in the middeck (40509).

  3. Analysis of In-Flight Winds for Shuttle Mission STS 51-L.

    NASA Astrophysics Data System (ADS)

    Fichtl, George H.; Reynolds, Nathaniel D.; Johnston, Alan E.; Adelfang, Stanley I.; Batts, Wade; Lott, Larry; Meyer, Paul J.; Smith, Orvel E.; Swint, Marion S.; Vaughan, Otha H., Jr.

    1988-11-01

    Television photos of smoke plumes an analyzed to estimate meridional wind shear on the space shuttle Challenger associated with the accident of Mission 51-L. Gust velocities were obtained by detailed examination of the debris trails. The shuttle exhaust trail was used to establish altitudes of significant features in the photographs. Wind data obtained from the photographs compare favorably with data obtained from a rawinsonde released 9 min after the launch of the shuttle.

  4. Analysis of in-flight winds for shuttle Mission STS 51-L

    NASA Technical Reports Server (NTRS)

    Fichtl, George H.; Reynolds, Nathaniel D.; Johnston, Alan E.; Adelfang, Stanley I.; Batts, Wade

    1988-01-01

    Television photos of smoke plumes are analyzed to estimate meridional wind shear on the space shuttle Challenger associated with the accident of Mission 51-L. Gust velocities were obtained by detailed examination of the debris trails. The shuttle exhaust trail was used to establish altitudes of significant features in the photographs. Wind data obtained from the photographs compare favorably with data obtained from a rawinsonde released 9 min after the launch of the shuttle.

  5. An Updated Review of Interventions that Include Promotion of Physical Activity for Adult Men.

    PubMed

    Bottorff, Joan L; Seaton, Cherisse L; Johnson, Steve T; Caperchione, Cristina M; Oliffe, John L; More, Kimberly; Jaffer-Hirji, Haleema; Tillotson, Sherri M

    2015-06-01

    The marked disparity in life expectancy between men and women suggests men are a vulnerable group requiring targeted health promotion programs. As such, there is an increasing need for health promotion strategies that effectively engage men with their health and/or illness management. Programs that promote physical activity could significantly improve the health of men. Although George et al. (Sports Med 42(3):281, 30) reviewed physical activity programs involving adult males published between 1990 and 2010, developments in men's health have prompted the emergence of new sex- and gender-specific approaches targeting men. The purpose of this review was to: (1) extend and update the review undertaken by George et al. (Sports Med 42(3):281, 30) concerning the effectiveness of physical activity programs in males, and (2) evaluate the integration of gender-specific influences in the content, design, and delivery of men's health promotion programs. A search of MEDLINE, CINAHL, ScienceDirect, Web of Science, PsycINFO, the Cochrane Library, and the SPORTDiscus databases for articles published between January 2010 and August 2014 was conducted. In total, 35 studies, involving evaluations of 31 programs, were identified. Findings revealed that a variety of techniques and modes of delivery could effectively promote physical activity among men. Though the majority of programs were offered exclusively to men, 12 programs explicitly integrated gender-related influences in male-specific programs in ways that recognized men's interests and preferences. Innovations in male-only programs that focus on masculine ideals and gender influences to engage men in increasing their physical activity hold potential for informing strategies to promote other areas of men's health. PMID:25430599

  6. Updating RIGs: Including the Systematic Influence of Online Study on Student Evaluation of Teaching

    ERIC Educational Resources Information Center

    Palmer, Stuart; Smith, Calvin

    2013-01-01

    Based on student evaluation of teaching (SET) ratings from 1,432 units of study over a period of a year, representing 74,490 individual sets of ratings, and including a significant number of units offered in wholly online mode, we confirm the significant influence of class size, year level, and discipline area on at least some SET ratings. We also…

  7. Questions and Answers on Copyright for the Campus Community. Updated (Includes Recent Court Decisions).

    ERIC Educational Resources Information Center

    Association of American Publishers, New York, NY.

    Intended for those members of the higher education community who write and publish (and that includes both students who write research papers, faculty who produce scholarly articles, copy centers, and college stores), this easy-to-understand guide explains the requirements of United States copyright law. The guide, in question and answer format,…

  8. Techniques for Updating Pedestrian Network Data Including Facilities and Obstructions Information for Transportation of Vulnerable People

    PubMed Central

    Park, Seula; Bang, Yoonsik; Yu, Kiyun

    2015-01-01

    Demand for a Pedestrian Navigation Service (PNS) is on the rise. To provide a PNS for the transportation of vulnerable people, more detailed information of pedestrian facilities and obstructions should be included in Pedestrian Network Data (PND) used for PNS. Such data can be constructed efficiently by collecting GPS trajectories and integrating them with the existing PND. However, these two kinds of data have geometric differences and topological inconsistencies that need to be addressed. In this paper, we provide a methodology for integrating pedestrian facilities and obstructions information with an existing PND. At first we extracted the significant points from user-collected GPS trajectory by identifying the geometric difference index and attributes of each point. Then the extracted points were used to make an initial solution of the matching between the trajectory and the PND. Two geometrical algorithms were proposed and applied to reduce two kinds of errors in the matching: on dual lines and on intersections. Using the final solution for the matching, we reconstructed the node/link structure of PND including the facilities and obstructions information. Finally, performance was assessed with a test site and 79.2% of the collected data were correctly integrated with the PND. PMID:26404307

  9. Update on the Human Broad Tapeworm (Genus Diphyllobothrium), Including Clinical Relevance

    PubMed Central

    Scholz, Tomáš; Garcia, Hector H.; Kuchta, Roman; Wicht, Barbara

    2009-01-01

    Summary: Tapeworms (Cestoda) continue to be an important cause of morbidity in humans worldwide. Diphyllobothriosis, a human disease caused by tapeworms of the genus Diphyllobothrium, is the most important fish-borne zoonosis caused by a cestode parasite. Up to 20 million humans are estimated to be infected worldwide. Besides humans, definitive hosts of Diphyllobothrium include piscivorous birds and mammals, which represent a significant zoonotic reservoir. The second intermediate hosts include both freshwater and marine fish, especially anadromous species such as salmonids. The zoonosis occurs most commonly in countries where the consumption of raw or marinated fish is a frequent practice. Due to the increasing popularity of dishes utilizing uncooked fish, numerous cases of human infections have appeared recently, even in the most developed countries. As many as 14 valid species of Diphyllobothrium can cause human diphyllobothriosis, with D. latum and D. nihonkaiense being the most important pathogens. In this paper, all taxa from humans reported are reviewed, with brief information on their life history and their current distribution. Data on diagnostics, epidemiology, clinical relevance, and control of the disease are also summarized. The importance of reliable identification of human-infecting species with molecular tools (sequences of mitochondrial genes) as well as the necessity of epidemiological studies aimed at determining the sources of infections are pointed out. PMID:19136438

  10. Techniques for Updating Pedestrian Network Data Including Facilities and Obstructions Information for Transportation of Vulnerable People.

    PubMed

    Park, Seula; Bang, Yoonsik; Yu, Kiyun

    2015-01-01

    Demand for a Pedestrian Navigation Service (PNS) is on the rise. To provide a PNS for the transportation of vulnerable people, more detailed information of pedestrian facilities and obstructions should be included in Pedestrian Network Data (PND) used for PNS. Such data can be constructed efficiently by collecting GPS trajectories and integrating them with the existing PND. However, these two kinds of data have geometric differences and topological inconsistencies that need to be addressed. In this paper, we provide a methodology for integrating pedestrian facilities and obstructions information with an existing PND. At first we extracted the significant points from user-collected GPS trajectory by identifying the geometric difference index and attributes of each point. Then the extracted points were used to make an initial solution of the matching between the trajectory and the PND. Two geometrical algorithms were proposed and applied to reduce two kinds of errors in the matching: on dual lines and on intersections. Using the final solution for the matching, we reconstructed the node/link structure of PND including the facilities and obstructions information. Finally, performance was assessed with a test site and 79.2% of the collected data were correctly integrated with the PND. PMID:26404307

  11. Portion of left hand SRB aft segment containing ET attach ring for 51-L

    NASA Technical Reports Server (NTRS)

    1986-01-01

    These two photographs show a portion of the left hand solid rocket booster (SRB) aft segment which contains the external tank (ET) attach ring for the 51-L mission resting on the ocean bottom in 210 feet of water approximately 23 miles east of the Kennedy Space Center (KSC). The photographs were take by the Deep Drone, a remotely controlled, unmanned U.S. Navy submersible. Photo 1 shows small fish below and to the left of the booster segment (10145); Photo two shows the opposite end of the segment. Visible from left are the clevis portion of the field joint and the external tank attach ring (10146).

  12. Signs of black smoke during Liftoff of the Shuttle Challenger STS 51-L

    NASA Technical Reports Server (NTRS)

    1986-01-01

    First evidence of black smoke near the right Shuttle Rocket Booster (SRB) near field joint, during Liftoff of the Shuttle Challenger STS 51-L. Time as OF0.445 Kennedy Space Center alternative photo number is 108-KSC-386C-660/2 (10096); Smoke is at its darkest at Time as OF1.606. KSC alternative photo number is 108-KSC-386C-660/75 (10097); Black smoke extends halfway across the right SRBat Times as OF2.147. KSC alternative photo number is 108-KSC-386C-660/160 (10098).

  13. Update on ischemic colitis: from etiopathology to treatment including patients of intensive care unit.

    PubMed

    Doulberis, Michael; Panagopoulos, Periklis; Scherz, Stephanie; Dellaporta, Erminia; Kouklakis, Georgios

    2016-08-01

    Ischemic colitis is the result of colonic hypoperfusion and is regarded as a relatively rare condition. It can be roughly classified as occlusive and non-occlusive. Pathogenesis includes a usually transient compromise in the colonic vasculature, with a parallel activation of an inflammatory cascade caused primarily by reperfusion. Diagnosis of ischemic colitis remains often difficult and requires a combination of diagnostic techniques, whereas clinical signs are occasionally only seen late as complications. Gold standard is considered to be colonoscopy. Clinical presentation and treatment of ischemic colitis vary widely depending on the degree of ischemia. Patients of intensive care unit (ICU) with ischemic colitis are often under-diagnosed, since the parallel co-morbidities and the nonspecific nature of symptoms that mimic almost any abdominal pathology, can mislead the doctor. Moreover, sedated or ventilated patients can mask many of the characteristic features of ischemic colitis and make the diagnosis challenging. Bedside colonoscopy and diagnostic laparoscopy in ICUs are two options, which seem lately to be reliable and promising in diagnosing ischemic colitis in critically ill patients. PMID:27152750

  14. An updated version of NPIDB includes new classifications of DNA-protein complexes and their families.

    PubMed

    Zanegina, Olga; Kirsanov, Dmitriy; Baulin, Eugene; Karyagina, Anna; Alexeevski, Andrei; Spirin, Sergey

    2016-01-01

    The recent upgrade of nucleic acid-protein interaction database (NPIDB, http://npidb.belozersky.msu.ru/) includes a newly elaborated classification of complexes of protein domains with double-stranded DNA and a classification of families of related complexes. Our classifications are based on contacting structural elements of both DNA: the major groove, the minor groove and the backbone; and protein: helices, beta-strands and unstructured segments. We took into account both hydrogen bonds and hydrophobic interaction. The analyzed material contains 1942 structures of protein domains from 748 PDB entries. We have identified 97 interaction modes of individual protein domain-DNA complexes and 17 DNA-protein interaction classes of protein domain families. We analyzed the sources of diversity of DNA-protein interaction modes in different complexes of one protein domain family. The observed interaction mode is sometimes influenced by artifacts of crystallization or diversity in secondary structure assignment. The interaction classes of domain families are more stable and thus possess more biological sense than a classification of single complexes. Integration of the classification into NPIDB allows the user to browse the database according to the interacting structural elements of DNA and protein molecules. For each family, we present average DNA shape parameters in contact zones with domains of the family. PMID:26656949

  15. UPDATE ON PEC ACTIVITIES INCLUDING NEW EVALUATION CRITERIA, THE APPLICATION COMPLETENESS CHECKLIST, AND STATUS OF THE WEBSITE DEVELOPMENT

    EPA Science Inventory

    US EPA's Pathogen Equivalency Committee (PEC) has updated the evaluation criteria it uses to make recommendations of equivalency (to processes acceptable under 40CFR503) on innovative or alternative sludge pathogen reduction processes. These criteria will be presented along with ...

  16. Initial Business Case Analysis of Two Integrated Heat Pump HVAC Systems for Near-Zero-Energy Homes - Update to Include Evaluation of Impact of Including a Humidifier Option

    SciTech Connect

    Baxter, Van D

    2007-02-01

    --A Stage 2 Scoping Assessment, ORNL/TM-2005/194 (Baxter 2005). The 2005 study report describes the HVAC options considered, the ranking criteria used, and the system rankings by priority. In 2006, the two top-ranked options from the 2005 study, air-source and ground-source versions of a centrally ducted integrated heat pump (IHP) system, were subjected to an initial business case study. The IHPs were subjected to a more rigorous hourly-based assessment of their performance potential compared to a baseline suite of equipment of legally minimum efficiency that provided the same heating, cooling, water heating, demand dehumidification, and ventilation services as the IHPs. Results were summarized in a project report, Initial Business Case Analysis of Two Integrated Heat Pump HVAC Systems for Near-Zero-Energy Homes, ORNL/TM-2006/130 (Baxter 2006a). The present report is an update to that document which summarizes results of an analysis of the impact of adding a humidifier to the HVAC system to maintain minimum levels of space relative humidity (RH) in winter. The space RH in winter has direct impact on occupant comfort and on control of dust mites, many types of disease bacteria, and 'dry air' electric shocks. Chapter 8 in ASHRAE's 2005 Handbook of Fundamentals (HOF) suggests a 30% lower limit on RH for indoor temperatures in the range of {approx}68-69F based on comfort (ASHRAE 2005). Table 3 in chapter 9 of the same reference suggests a 30-55% RH range for winter as established by a Canadian study of exposure limits for residential indoor environments (EHD 1987). Harriman, et al (2001) note that for RH levels of 35% or higher, electrostatic shocks are minimized and that dust mites cannot live at RH levels below 40%. They also indicate that many disease bacteria life spans are minimized when space RH is held within a 30-60% range. From the foregoing it is reasonable to assume that a winter space RH range of 30-40% would be an acceptable compromise between comfort

  17. Generation and structural validation of a library of diverse xyloglucan-derived oligosaccharides, including an update on xyloglucan nomenclature.

    PubMed

    Tuomivaara, Sami T; Yaoi, Katsuro; O'Neill, Malcolm A; York, William S

    2015-01-30

    Xyloglucans are structurally complex plant cell wall polysaccharides that are involved in cell growth and expansion, energy metabolism, and signaling. Determining the structure-function relationships of xyloglucans would benefit from the availability of a comprehensive and structurally diverse collection of rigorously characterized xyloglucan oligosaccharides. Here, we present a workflow for the semi-preparative scale generation and purification of neutral and acidic xyloglucan oligosaccharides using a combination of enzymatic and chemical treatments and size-exclusion chromatography. Twenty-six of these oligosaccharides were purified to near homogeneity and their structures validated using a combination of matrix-assisted laser desorption/ionization mass spectrometry, high-performance anion exchange chromatography, and 1H nuclear magnetic resonance spectroscopy. Mass spectrometry and analytical chromatography were compared as methods for xyloglucan oligosaccharide quantification. 1H chemical shifts were assigned using two-dimensional correlation spectroscopy. A comprehensive update of the nomenclature describing xyloglucan side-chain structures is provided for reference. PMID:25497333

  18. Seismic response trends evaluation via long term monitoring and finite element model updating of an RC building including soil-structure interaction

    NASA Astrophysics Data System (ADS)

    Butt, F.; Omenzetter, P.

    2012-04-01

    This paper presents a study on the seismic response trends evaluation and finite element model updating of a reinforced concrete building monitored for a period of more than two years. The three storey reinforced concrete building is instrumented with five tri-axial accelerometers and a free-field tri-axial accelerometer. The time domain N4SID system identification technique was used to obtain the frequencies and damping ratios considering flexible base models taking into account the soil-structure-interaction (SSI) using 50 earthquakes. Trends of variation of seismic response were developed by correlating the peak response acceleration at the roof level with identified frequencies and damping ratios. A general trend of decreasing frequencies was observed with increased level of shaking. To simulate the behavior of the building, a three dimensional finite element model (FEM) was developed. To incorporate real in-situ conditions, soil underneath the foundation and around the building was modeled using spring elements and non-structural components (claddings and partitions) were also included. The developed FEM was then calibrated using a sensitivity based model updating technique taking into account soil flexibility and non-structural components as updating parameters. It was concluded from the investigation that knowledge of the variation of seismic response of buildings is necessary to better understand their behavior during earthquakes, and also that the participation of soil and non-structural components is significant towards the seismic response of the building and these should be considered in models to simulate the real behavior.

  19. Update on medical and regulatory issues pertaining to compounded and FDA-approved drugs, including hormone therapy

    PubMed Central

    Pinkerton, JoAnn V.; Pickar, James H.

    2016-01-01

    Abstract Objective: We review the historical regulation of drug compounding, concerns about widespread use of non-Food and Drug Admiistration (FDA)-approved compounded bioidentical hormone therapies (CBHTs), which do not have proper labeling and warnings, and anticipated impact of the 2013 Drug Quality and Security Act (DQSA) on compounding. Methods: US government websites were searched for documents concerning drug compounding regulation and oversight from 1938 (passage of Federal Food, Drug, and Cosmetic Act [FDCA]) through 2014, including chronologies, Congressional testimony, FDA guidelines and enforcements, and reports. The FDCA and DQSA were reviewed. PubMed and Google were searched for articles on compounded drugs, including CBHT. Results: Congress explicitly granted the FDA limited oversight of compounded drugs in a 1997 amendment to the FDCA, but the FDA has encountered obstacles in exercising that authority. After 64 patient deaths and 750 adversely affected patients from the 2012 meningitis outbreak due to contaminated compounded steroid injections, Congress passed the DQSA, authorizing the FDA to create a voluntary registration for facilities that manufacture and distribute sterile compounded drugs in bulk and reinforcing FDCA regulations for traditional compounding. Given history and current environment, concerns remain about CBHT product regulation and their lack of safety and efficacy data. Conclusions: The DQSA and its reinforcement of §503A of the FDCA solidifies FDA authority to enforce FDCA provisions against compounders of CBHT. The new law may improve compliance and accreditation by the compounding industry; support state and FDA oversight; and prevent the distribution of misbranded, adulterated, or inconsistently compounded medications, and false and misleading claims, thus reducing public health risk. PMID:26418479

  20. A novel PLAG1-RAD51L1 gene fusion resulting from a t(8;14)(q12;q24) in a case of lipoblastoma.

    PubMed

    Deen, Mazin; Ebrahim, Salah; Schloff, Debbie; Mohamed, Anwar N

    2013-06-01

    Lipoblastomas are rare benign tumors that arise from embryonic adipose tissue and occur predominantly in the pediatric population. Here, we report a case of lipoblastoma in an 8-month-old boy. Surgical excision and subsequent histopathologic examination were consistent with features of lipoblastoma. Chromosome analysis of the tumor revealed a clonal unbalanced t(8;14) translocation. Genomic microarray analysis of the tumor delineated the exact breakpoints at 8q12.1 and 14q24.1, which involved the PLAG1 and RADA51L1 genes, respectively. Furthermore, fluorescence in situ hybridization demonstrated that the translocation fused the PLAG1-RAD51L1 genes. These results suggest that RAD51L1 is an alternative fusion partner gene for the PLAG1 gene in a lipoblastoma with an 8q12 rearrangement. PMID:23890983

  1. View of the STS 51-L Memorial service on JSC's main mall

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Memorial services for the Challenger Seven were conducted on the morning of Jan. 31, 1986 at JSC's main mall. Among those in attendance were former and present astronauts and Space Shuttle payload specialists (PS). U.S. Sen. Jake Garn (R., Utah) vists at center with Sultan Salman Abdelazize Al-Saud of Saudi Arabia. Others pictured include German PS Ulf Merbold, French PS Patrick Baudry and NASA Astronauts Robert L. Stewart, Marsha S. Ivins, David C. Leestma and C. Gordon Fullerton, along with former astronaut Eugene A. Cernan.

  2. An updated checklist and key to the open-panicled species of Poa L. (Poaceae) in Peru including three new species, Poa ramoniana, Poa tayacajaensis, and Poa urubambensis

    PubMed Central

    Sylvester, Steven P.; Soreng, Robert J.; Peterson, Paul M.; Sylvester, Mitsy D.P.V.

    2016-01-01

    Abstract We provide an updated checklist and key to the 30 Poa species with open panicles from Peru which includes previously circumscribed Dissanthelium and Aphanelytrum species, new taxon records, and three undescribed species. Poa compressa, Poa grisebachii, and Poa leioclada are recorded from Peru for the first time. A number of species are placed in synonymy: Poa carazensis, Poa ferreyrae and Poa tovarii are synonymized under the name Poa fibrifera; Poa adusta (tentatively) and Poa pilgeri are synonymized under Poa candamoana; Poa superata is synonymized under Poa grisebachii; and Poa paramoensis is synonymized under Poa huancavelicae. Included within this treatment are three new species, Poa ramoniana, Poa tayacajaensis and Poa urubambensis, which are described and illustrated. Poa ramoniana, found growing near lakes in high elevation Puna grasslands of Junín, is similar to a small form of Poa glaberrima, but differs in having rhizomes and growing to only 5 cm tall. Poa tayacajaensis, found from shrublands on Andean slopes of Huancavelica and Huánuco, bears similarities to Poa aequatoriensis but differs in having shorter lemmas which are pubescent between the veins, densely scabrous sheaths with smooth, glabrous throats, and shorter ligules. Poa urubambensis, a common element of the undisturbed Polylepis forest understory of the Cordillera Urubamba, Cusco, is distinct from all other members of open-panicled Poa’s by having glabrous lemmas with a smooth and glabrous callus, and notably small anthers. The type material for the name Poa adusta is discussed and a lectotype is selected. PMID:27489489

  3. An updated checklist and key to the open-panicled species of Poa L. (Poaceae) in Peru including three new species, Poa ramoniana, Poa tayacajaensis, and Poa urubambensis.

    PubMed

    Sylvester, Steven P; Soreng, Robert J; Peterson, Paul M; Sylvester, Mitsy D P V

    2016-01-01

    We provide an updated checklist and key to the 30 Poa species with open panicles from Peru which includes previously circumscribed Dissanthelium and Aphanelytrum species, new taxon records, and three undescribed species. Poa compressa, Poa grisebachii, and Poa leioclada are recorded from Peru for the first time. A number of species are placed in synonymy: Poa carazensis, Poa ferreyrae and Poa tovarii are synonymized under the name Poa fibrifera; Poa adusta (tentatively) and Poa pilgeri are synonymized under Poa candamoana; Poa superata is synonymized under Poa grisebachii; and Poa paramoensis is synonymized under Poa huancavelicae. Included within this treatment are three new species, Poa ramoniana, Poa tayacajaensis and Poa urubambensis, which are described and illustrated. Poa ramoniana, found growing near lakes in high elevation Puna grasslands of Junín, is similar to a small form of Poa glaberrima, but differs in having rhizomes and growing to only 5 cm tall. Poa tayacajaensis, found from shrublands on Andean slopes of Huancavelica and Huánuco, bears similarities to Poa aequatoriensis but differs in having shorter lemmas which are pubescent between the veins, densely scabrous sheaths with smooth, glabrous throats, and shorter ligules. Poa urubambensis, a common element of the undisturbed Polylepis forest understory of the Cordillera Urubamba, Cusco, is distinct from all other members of open-panicled Poa's by having glabrous lemmas with a smooth and glabrous callus, and notably small anthers. The type material for the name Poa adusta is discussed and a lectotype is selected. PMID:27489489

  4. Colombia Mi Pronostico Flood Application: Updating and Improving the Mi Pronostico Flood Web Application to Include an Assessment of Flood Risk

    NASA Technical Reports Server (NTRS)

    Rushley, Stephanie; Carter, Matthew; Chiou, Charles; Farmer, Richard; Haywood, Kevin; Pototzky, Anthony, Jr.; White, Adam; Winker, Daniel

    2014-01-01

    Colombia is a country with highly variable terrain, from the Andes Mountains to plains and coastal areas, many of these areas are prone to flooding disasters. To identify these risk areas NASA's Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) was used to construct a digital elevation model (DEM) for the study region. The preliminary risk assessment was applied to a pilot study area, the La Mosca River basin. Precipitation data from the National Aeronautics and Space Administration (NASA) Tropical Rainfall Measuring Mission (TRMM)'s near-real-time rainfall products as well as precipitation data from the Instituto de Hidrologia, Meteorologia y Estudios Ambientales (the Institute of Hydrology, Meteorology and Environmental Studies, IDEAM) and stations in the La Mosca River Basin were used to create rainfall distribution maps for the region. Using the precipitation data and the ASTER DEM, the web application, Mi Pronóstico, run by IDEAM, was updated to include an interactive map which currently allows users to search for a location and view the vulnerability and current weather and flooding conditions. The geospatial information was linked to an early warning system in Mi Pronóstico that can alert the public of flood warnings and identify locations of nearby shelters.

  5. Operational real-time modeling with ensemble Kalman filter of variably saturated subsurface flow including stream-aquifer interaction and parameter updating

    NASA Astrophysics Data System (ADS)

    Hendricks Franssen, H. J.; Kaiser, H. P.; Kuhlmann, U.; Bauser, G.; Stauffer, F.; Müller, R.; Kinzelbach, W.

    2011-02-01

    Urban groundwater is frequently contaminated, and the exact location of the pollution spots is often unknown. Intelligent monitoring of the temporal variations in groundwater flow in such an area assists in selectively extracting groundwater of drinking water quality. Here an example from the city of Zurich (Switzerland) is shown. The monitoring strategy consists of using the ensemble Kalman filter (EnKF) for optimally combining online observations and online models for the real-time characterization of groundwater flow. We conducted numerical simulation experiments for the period January 2004 to December 2007 with a 3-D finite element model for variably saturated groundwater flow. It was found that the daily assimilation of piezometric head data with EnKF results in a better characterization of piezometric heads than does a model which is inversely calibrated with historical data but not updated in real time. The positive impact of model updating with observations can still be observed 10 days after the update. These simulations also suggest that parameters (hydraulic conductivity and leakage) are successfully updated: 1 and 10 day piezometric head predictions are better with than without updating of parameters. Additional experiments with a synthetic model for the same site, in which the only difference is that certain parameter values are selected as the unknown "true" conditions, show that EnKF also successfully updates unknown parameters. However, this is only the case if spatially distributed hydraulic conductivities and leakage coefficients are jointly updated and if a damping parameter is used. The mean absolute error of estimated log leakage coefficients decreased by up to 63%; for log hydraulic conductivity a decrease of up to 27% was observed. From January 2009 the method has been operational at the Water Works Zurich and showed a remarkable performance until present (October 2010).

  6. An updated check list of the Cochylina (Tortricidae, Tortricinae, Euliini) of North America north of Mexico including Greenland, with comments on classification and identification

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We present an updated list of the members of the subtribe Cochylina (Tortricidae) in North America north of Mexico. We summarize the proposed changes in the classification since about 1983. We propose revised status for two genera, Rolandylis Gibeaux, 1985 and Thyraylia Walsingham, 1897. We propose ...

  7. An Update on Methods for Revascularization and Expansion of the TASC Lesion Classification to Include Below-the-Knee Arteries: A Supplement to the Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)

    PubMed Central

    Jaff, *Michael R.; White, Christopher J.; Hiatt, William R.; Fowkes, Gerry R.; Dormandy, John; Razavi, Mahmood; Reekers, Jim

    2015-01-01

    The Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC) guidelines were last updated in 2007 (TASC II) and represented the collaboration of international vascular specialties involved in the management of patients with peripheral arterial disease (PAD). Since the publication of TASC II, there have been innovations in endovascular revascularization strategies for patients with PAD. The intent of this publication is to provide a complete anatomic lower limb TASC lesion classification, including the infrapopliteal segment, and an updated literature review of new endovascular techniques and practice patterns employed by vascular specialists today. PMID:26730266

  8. An Update on Methods for Revascularization and Expansion of the TASC Lesion Classification to Include Below-the-Knee Arteries: A Supplement to the Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II).

    PubMed

    Jaff, Michael R; White, Christopher J; Hiatt, William R; Fowkes, Gerry R; Dormandy, John; Razavi, Mahmood; Reekers, Jim; Norgren, Lars

    2015-10-01

    The Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC) guidelines were last updated in 2007 (TASC II) and represented the collaboration of international vascular specialties involved in the management of patients with peripheral arterial disease (PAD). Since the publication of TASC II, there have been innovations in endovascular revascularization strategies for patients with PAD. The intent of this publication is to provide a complete anatomic lower limb TASC lesion classification, including the infrapopliteal segment, and an updated literature review of new endovascular techniques and practice patterns employed by vascular specialists today. PMID:26239796

  9. Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.

    PubMed

    Figueroa, Jonine D; Garcia-Closas, Montserrat; Humphreys, Manjeet; Platte, Radka; Hopper, John L; Southey, Melissa C; Apicella, Carmel; Hammet, Fleur; Schmidt, Marjanka K; Broeks, Annegien; Tollenaar, Rob A E M; Van't Veer, Laura J; Fasching, Peter A; Beckmann, Matthias W; Ekici, Arif B; Strick, Reiner; Peto, Julian; dos Santos Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael; Burwinkel, Barbara; Marme, Federik; Schneeweiss, Andreas; Sohn, Christof; Bojesen, Stig; Flyger, Henrik; Nordestgaard, Børge G; Benítez, Javier; Milne, Roger L; Ignacio Arias, Jose; Zamora, M Pilar; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Rahman, Nazneen; Turnbull, Clare; Seal, Sheila; Renwick, Anthony; Brauch, Hiltrud; Justenhoven, Christina; Brüning, Thomas; Chang-Claude, Jenny; Hein, Rebecca; Wang-Gohrke, Shan; Dörk, Thilo; Schürmann, Peter; Bremer, Michael; Hillemanns, Peter; Nevanlinna, Heli; Heikkinen, Tuomas; Aittomäki, Kristiina; Blomqvist, Carl; Bogdanova, Natalia; Antonenkova, Natalia; Rogov, Yuri I; Karstens, Johann Hinrich; Bermisheva, Marina; Prokofieva, Darya; Gantcev, Shamil Hanafievich; Khusnutdinova, Elza; Lindblom, Annika; Margolin, Sara; Chenevix-Trench, Georgia; Beesley, Jonathan; Chen, Xiaoqing; Mannermaa, Arto; Kosma, Veli-Matti; Soini, Ylermi; Kataja, Vesa; Lambrechts, Diether; Yesilyurt, Betül T; Chrisiaens, Marie-Rose; Peeters, Stephanie; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Barile, Monica; Couch, Fergus; Lee, Adam M; Diasio, Robert; Wang, Xianshu; Giles, Graham G; Severi, Gianluca; Baglietto, Laura; Maclean, Catriona; Offit, Ken; Robson, Mark; Joseph, Vijai; Gaudet, Mia; John, Esther M; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene; Knight, Julia A; Mulligan, Anna Marie; O'Malley, Frances P; Brinton, Louise A; Sherman, Mark E; Lissowska, Jolanta; Chanock, Stephen J; Hooning, Maartje; Martens, John W M; van den Ouweland, Ans M W; Collée, J Margriet; Hall, Per; Czene, Kamila; Cox, Angela; Brock, Ian W; Reed, Malcolm W R; Cross, Simon S; Pharoah, Paul; Dunning, Alison M; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Shen, Chen-Yang; Ding, Shian-ling; Hsu, Huan-Ming; Yu, Jyh-Cherng; Anton-Culver, Hoda; Ziogas, Argyrios; Ashworth, Alan; Swerdlow, Anthony; Jones, Michael; Orr, Nick; Trentham-Dietz, Amy; Egan, Kathleen; Newcomb, Polly; Titus-Ernstoff, Linda; Easton, Doug; Spurdle, Amanda B

    2011-12-01

    A genome-wide association study (GWAS) identified single-nucleotide polymorphisms (SNPs) at 1p11.2 and 14q24.1 (RAD51L1) as breast cancer susceptibility loci. The initial GWAS suggested stronger effects for both loci for estrogen receptor (ER)-positive tumors. Using data from the Breast Cancer Association Consortium (BCAC), we sought to determine whether risks differ by ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), grade, node status, tumor size, and ductal or lobular morphology. We genotyped rs11249433 at 1p.11.2, and two highly correlated SNPs rs999737 and rs10483813 (r(2)= 0.98) at 14q24.1 (RAD51L1), for up to 46 036 invasive breast cancer cases and 46 930 controls from 39 studies. Analyses by tumor characteristics focused on subjects reporting to be white women of European ancestry and were based on 25 458 cases, of which 87% had ER data. The SNP at 1p11.2 showed significantly stronger associations with ER-positive tumors [per-allele odds ratio (OR) for ER-positive tumors was 1.13, 95% CI = 1.10-1.16 and, for ER-negative tumors, OR was 1.03, 95% CI = 0.98-1.07, case-only P-heterogeneity = 7.6 × 10(-5)]. The association with ER-positive tumors was stronger for tumors of lower grade (case-only P= 6.7 × 10(-3)) and lobular histology (case-only P= 0.01). SNPs at 14q24.1 were associated with risk for most tumor subtypes evaluated, including triple-negative breast cancers, which has not been described previously. Our results underscore the need for large pooling efforts with tumor pathology data to help refine risk estimates for SNP associations with susceptibility to different subtypes of breast cancer. PMID:21852249

  10. Afrotropical Ophioninae (Hymenoptera, Ichneumonidae): an update of Gauld and Mitchell’s revision, including two new species and an interactive matrix identification key

    PubMed Central

    Rousse, Pascal; van Noort, Simon

    2014-01-01

    Abstract The revision of the Afrotropical Ophioninae is updated, based on the examination of about 800–900 individuals in the South African and European museum collections. A robust interactive matrix key was built to provide quick and reliable identifications. The key is available online at http://www.waspweb.org. Two new species are described: Dicamptus maxipol sp. n. and Enicospilus gauldetmitchellorum sp. n. Numerous new distribution and biological records are provided, and noticeable morphological intra-specific variations are detailed. Enicospilus batus Gauld & Mitchell, syn. n. is considered as a junior synonym of Enicospilus luebberti (Enderlein). PMID:25709521

  11. Afrotropical Ophioninae (Hymenoptera, Ichneumonidae): an update of Gauld and Mitchell's revision, including two new species and an interactive matrix identification key.

    PubMed

    Rousse, Pascal; van Noort, Simon

    2014-01-01

    The revision of the Afrotropical Ophioninae is updated, based on the examination of about 800-900 individuals in the South African and European museum collections. A robust interactive matrix key was built to provide quick and reliable identifications. The key is available online at http://www.waspweb.org. Two new species are described: Dicamptusmaxipol sp. n. and Enicospilusgauldetmitchellorum sp. n. Numerous new distribution and biological records are provided, and noticeable morphological intra-specific variations are detailed. Enicospilusbatus Gauld & Mitchell, syn. n. is considered as a junior synonym of Enicospilusluebberti (Enderlein). PMID:25709521

  12. Update '98.

    ERIC Educational Resources Information Center

    Mock, Karen R.

    1998-01-01

    Updates cases and issues previously discussed in this regular column on human rights in Canada, including racism and anti-Semitism, laws on hate crimes, hate sites on the World Wide Web, the use of the "free speech" defense by hate groups, and legal challenges to antiracist groups by individuals criticized by them. (DSK)

  13. Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium†

    PubMed Central

    Figueroa, Jonine D.; Garcia-Closas, Montserrat; Humphreys, Manjeet; Platte, Radka; Hopper, John L.; Southey, Melissa C.; Apicella, Carmel; Hammet, Fleur; Schmidt, Marjanka K.; Broeks, Annegien; Tollenaar, Rob A.E.M.; Van't Veer, Laura J.; Fasching, Peter A.; Beckmann, Matthias W.; Ekici, Arif B.; Strick, Reiner; Peto, Julian; dos Santos Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael; Burwinkel, Barbara; Marme, Federik; Schneeweiss, Andreas; Sohn, Christof; Bojesen, Stig; Flyger, Henrik; Nordestgaard, Børge G.; Benítez, Javier; Milne, Roger L.; Ignacio Arias, Jose; Zamora, M. Pilar; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Rahman, Nazneen; Turnbull, Clare; Seal, Sheila; Renwick, Anthony; Brauch, Hiltrud; Justenhoven, Christina; Brüning, Thomas; Chang-Claude, Jenny; Hein, Rebecca; Wang-Gohrke, Shan; Dörk, Thilo; Schürmann, Peter; Bremer, Michael; Hillemanns, Peter; Nevanlinna, Heli; Heikkinen, Tuomas; Aittomäki, Kristiina; Blomqvist, Carl; Bogdanova, Natalia; Antonenkova, Natalia; Rogov, Yuri I.; Karstens, Johann Hinrich; Bermisheva, Marina; Prokofieva, Darya; Hanafievich Gantcev, Shamil; Khusnutdinova, Elza; Lindblom, Annika; Margolin, Sara; Chenevix-Trench, Georgia; Beesley, Jonathan; Chen, Xiaoqing; Mannermaa, Arto; Kosma, Veli-Matti; Soini, Ylermi; Kataja, Vesa; Lambrechts, Diether; Yesilyurt, Betül T.; Chrisiaens, Marie-Rose; Peeters, Stephanie; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Barile, Monica; Couch, Fergus; Lee, Adam M.; Diasio, Robert; Wang, Xianshu; Giles, Graham G.; Severi, Gianluca; Baglietto, Laura; Maclean, Catriona; Offit, Ken; Robson, Mark; Joseph, Vijai; Gaudet, Mia; John, Esther M.; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene; Knight, Julia A.; Marie Mulligan, Anna; O'Malley, Frances P.; Brinton, Louise A.; Sherman, Mark E.; Lissowska, Jolanta; Chanock, Stephen J.; Hooning, Maartje; Martens, John W.M.; van den Ouweland, Ans M.W.; Collée, J. Margriet; Hall, Per; Czene, Kamila; Cox, Angela; Brock, Ian W.; Reed, Malcolm W.R.; Cross, Simon S.; Pharoah, Paul; Dunning, Alison M.; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Shen, Chen-Yang; Ding, Shian-ling; Hsu, Huan-Ming; Yu, Jyh-Cherng; Anton-Culver, Hoda; Ziogas, Argyrios; Ashworth, Alan; Swerdlow, Anthony; Jones, Michael; Orr, Nick; Trentham-Dietz, Amy; Egan, Kathleen; Newcomb, Polly; Titus-Ernstoff, Linda; Easton, Doug; Spurdle, Amanda B.

    2011-01-01

    A genome-wide association study (GWAS) identified single-nucleotide polymorphisms (SNPs) at 1p11.2 and 14q24.1 (RAD51L1) as breast cancer susceptibility loci. The initial GWAS suggested stronger effects for both loci for estrogen receptor (ER)-positive tumors. Using data from the Breast Cancer Association Consortium (BCAC), we sought to determine whether risks differ by ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), grade, node status, tumor size, and ductal or lobular morphology. We genotyped rs11249433 at 1p.11.2, and two highly correlated SNPs rs999737 and rs10483813 (r2= 0.98) at 14q24.1 (RAD51L1), for up to 46 036 invasive breast cancer cases and 46 930 controls from 39 studies. Analyses by tumor characteristics focused on subjects reporting to be white women of European ancestry and were based on 25 458 cases, of which 87% had ER data. The SNP at 1p11.2 showed significantly stronger associations with ER-positive tumors [per-allele odds ratio (OR) for ER-positive tumors was 1.13, 95% CI = 1.10–1.16 and, for ER-negative tumors, OR was 1.03, 95% CI = 0.98–1.07, case-only P-heterogeneity = 7.6 × 10−5]. The association with ER-positive tumors was stronger for tumors of lower grade (case-only P= 6.7 × 10−3) and lobular histology (case-only P= 0.01). SNPs at 14q24.1 were associated with risk for most tumor subtypes evaluated, including triple-negative breast cancers, which has not been described previously. Our results underscore the need for large pooling efforts with tumor pathology data to help refine risk estimates for SNP associations with susceptibility to different subtypes of breast cancer. PMID:21852249

  14. Energy savings for heat-island reduction strategies in Chicago and Houston (including updates for Baton Rouge, Sacramento, and Salt Lake City)

    SciTech Connect

    Konopacki, S.; Akbari, H.

    2002-02-28

    In 1997, the U.S. Environmental Protection Agency (EPA) established the ''Heat Island Reduction Initiative'' to quantify the potential benefits of Heat-Island Reduction (HIR) strategies (i.e., shade trees, reflective roofs, reflective pavements and urban vegetation) to reduce cooling-energy use in buildings, lower the ambient air temperature and improve urban air quality in cities, and reduce CO2 emissions from power plants. Under this initiative, the Urban Heat Island Pilot Project (UHIPP) was created with the objective of investigating the potential of HIR strategies in residential and commercial buildings in three initial UHIPP cities: Baton Rouge, LA; Sacramento, CA; and Salt Lake City, UT. Later two other cities, Chicago, IL and Houston, TX were added to the UHIPP. In an earlier report we summarized our efforts to calculate the annual energy savings, peak power avoidance, and annual CO2 reduction obtainable from the introduction of HIR strategies in the initial three cities. This report summarizes the results of our study for Chicago and Houston. In this analysis, we focused on three building types that offer the highest potential savings: single-family residence, office and retail store. Each building type was characterized in detail by vintage and system type (i.e., old and new building constructions, and gas and electric heat). We used the prototypical building characteristics developed earlier for each building type and simulated the impact of HIR strategies on building cooling- and heating-energy use and peak power demand using the DOE-2.1E model. Our simulations included the impact of (1) strategically-placed shade trees near buildings [direct effect], (2) use of high-albedo roofing material on the building [direct effect], (3) urban reforestation with high-albedo pavements and building surfaces [indirect effect] and (4) combined strategies 1, 2, and 3 [direct and indirect effects]. We then estimated the total roof area of air-conditioned buildings in

  15. A Report on the Upper-Level Wind Conditions Preceding and During the Shuttle Challenger (STS 51L) Explosion.

    NASA Astrophysics Data System (ADS)

    Uccellini, Louis W.; Petersen, Ralph A.; Keyser, Daniel; Kocin, Paul J.; Des Jardins, Mary; Brill, Keith F.; Aune, Robert

    1986-10-01

    The synoptic-scale weather conditions preceding and following the ill-fated Space Shuttle Challenger launch are documented, with particular emphasis on the upper-level winds for central and northern Florida. Operational radiosonde data collected by the National Weather Service, visible and infrared imagery from the Geo-stationary Operational Environmental Satellite, and water-vapor imagery from the VISSR (Visible Infrared Spin Scan Radiometer) Atmospheric Sounder, ozone data collected by the Total Ozone Mapping Spectrometer aboard the Nimbus-7, and soundings collected at Cape Canaveral (XMR) are described. Analysts derived from these data sets point to the juxtaposition of two distinct jet-stream systems (a polar-front jet. [PFJ] and a subtropical jet [STJ]) over north-central Florida on the morning of the launch. Both jets were characterized by regions of significant vertical wind shear, which was especially strong above and below the core of the STJ.Data from a radiosonde released at Cape Canaveral 10 min after the shuttle accident combined with radiosonde and jimsphere wind measurements before the shuttle launch reveal that, over XMR, the magnitude of the maximum wind in the PFJ was increasing with time while the magnitude of the STJ was decreasing. Even with the decreasing magnitude of wind speeds in the core of the STJ over XMR, large vertical wind shears and low Richardson numbers were still diagnosed near the PFJ and beneath the core of the STJ at the time of launch (1639 GMT). The low Richardson numbers associated with the presence of vertical wind shear indicate that conditions were favorable for shear-induced turbulence at the time of the shuttle explosion.The results from the analyses of the synoptic radiosonde data are inconclusive due to the poor temporal and horizontal spatial resolution of the observational data base and the large number of missing data reports at numerous stations in the southeastern United States (including XMR). In an attempt to

  16. [Pharmacovigilance update].

    PubMed

    Fogarasi Szabo, Nathalie; Diezi, Léonore; Delenclos, Laurie; Renard, Delphine; Chtioui, Haithem; Rothuizen, Laura E; Buclin, Thierry; Livio, Françoise

    2015-01-14

    The main pharmacovigilance updates in 2014 are reviewed. Ivabradine: increased risk of cardiovascular death and myocardial infarction in patients with symptomatic angina treated with high dosages. Clopidogrel: rare observations of acquired hemophilia. Orlistat: may reduce the absorption of HIV antiretrovirals. Ponatinib: increased risk of arteriopathy and thrombosis. Axitinib: significant risk of heart failure (class effect). Tocilizumab: possible causal relationship with the emergence or aggravation of psoriasis. Lithium: hypercalcemia and hyperparathyroidism commonly observed. Sildenalfil: suspected causal association with melanoma, so far not proven, Methylphenidate: rare observations of priapism. St John's wort (Hypericum): reduced effectiveness of hormonal contraceptives, including implants. PMID:25799668

  17. Country Update: Israel 2005

    ERIC Educational Resources Information Center

    Marar, Marianne Maurice

    2005-01-01

    Country Updates is a new section of "Intercultural Education." Starting in "Intercultural Education," Volume 16 No. 5, this column will focus on recent developments during the last two to three years in the field of intercultural education in one particular country. These updates can include recent policy decisions, the main results of important…

  18. Update of the BIPM comparison BIPM.RI(II)-K1.Sr-85 of activity measurements of the radionuclide 85Sr to include the 2009 result of the POLATOM (Poland)

    NASA Astrophysics Data System (ADS)

    Michotte, C.; Ratel, G.; Courte, S.; Dziel, T.; Listkowska, A.

    2015-01-01

    Since 1975, ten laboratories have submitted 27 samples of known activity of 85Sr to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Sr-85. The values of the activity submitted were between about 0.2 MBq and 19 MBq. The key comparison reference value (KCRV) has been recalculated to include the primary standardization result for the POLATOM, Poland. There are now four results in the BIPM.RI(II)-K1.Sr-85 comparison. The degrees of equivalence between each equivalent activity measured in the SIR and the updated KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  19. ISS Update: NEEMO 16

    NASA Video Gallery

    ISS Update commentator Josh Byerly interviews astronaut Stan Love about the NEEMO 16 mission from Aquarius Base. Questions? Ask us on Twitter @NASA_Johnson and include the hashtag #askStation. For ...

  20. CREME96 Update/Replacement Efforts

    NASA Technical Reports Server (NTRS)

    Adams, Jim H.

    2007-01-01

    This talk concerns the plans to update the CREME96 model that is currently available on the WWW. The talk states the reasons for updating C REME. It describes the updates that are planned, including the single event prediction paradigm, the method of radiation transport through the spacecraft to the electronic component of interest and the planned updates to models for the space radiation environment. It also revi ews user suggestions received do date for the update.

  1. An update on methods for revascularization and expansion of the TASC lesion classification to include below-the-knee arteries: A supplement to the inter-society consensus for the management of peripheral arterial disease (TASC II): The TASC steering committee.

    PubMed

    Jaff, Michael R; White, Christopher J; Hiatt, William R; Fowkes, Gerry R; Dormandy, John; Razavi, Mahmood; Reekers, Jim; Norgren, Lars

    2015-10-01

    The Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC) guidelines were last updated in 2007 (TASC II) and represented the collaboration of international vascular specialties involved in the management of patients with peripheral arterial disease (PAD). Since the publication of TASC II, there have been innovations in endovascular revascularization strategies for patients with PAD. The intent of this publication is to provide a complete anatomic lower limb TASC lesion classification, including the infrapopliteal segment, and an updated literature review of new endovascular techniques and practice patterns employed by vascular specialists today. PMID:26256456

  2. Email Updates

    MedlinePlus

    ... unsubscribe. Prevent MedlinePlus emails from being marked as "spam" or "junk" To ensure that MedlinePlus email updates ... com to your email address book, adjust your spam settings, or follow the instructions from your email ...

  3. A Machine-Portable CDC UPDATE Emulator.

    1987-09-01

    Version 01 UPEML is a machine-portable CDC UPDATE emulation program. It is capable of emulating a significant subset of the standard CDC UPDATE functions, including program library creation and subsequent modification.

  4. Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the 2010 result of the LNE-LNHB (France)

    NASA Astrophysics Data System (ADS)

    Michotte, C.; Ratel, G.; Courte, S.; Cassette, P.; Moune, M.

    2016-01-01

    Since 2001, six national metrology institutes (NMI) have submitted seven samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.F-18. The values of the activity submitted were between about 1 MBq and 18 MBq. The primary standardization result for the LNE-LNHB, France, replaces their earlier result of 2002 and the key comparison reference value (KCRV) has been recalculated. In the frame of the BIPM.RI(II)-K4.F18 comparison, the NPL updated their result in the KCDB. Consequently there are now five results in the BIPM.RI(II)-K1.F-18 comparison. The degrees of equivalence between each equivalent activity measured in the SIR and the updated KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  5. Plus updates.

    PubMed

    Parkhouse, Richard C

    2008-01-01

    Inevitably, with an innovative and fast growing technique, improvements in hardware and refinements are ongoing. So it is with Plus. Therefore there are some relevant updates, subsequent to my article "Current Products and Practice: Tip-Edge Plus" (reprinted in the last issue of International Journalof Orthodontics by kind permission of the British Journal of Orthodontics). PMID:19263632

  6. Updating Older Fume Hoods.

    ERIC Educational Resources Information Center

    Saunders, G. Thomas

    1985-01-01

    Provides information on updating older fume hoods. Areas addressed include: (1) adjustment of the hood's back baffle; (2) hood air leakage; (3) light level; (4) hood location in relation to room traffic and room air; and (5) establishing and maintaining hood performance. (JN)

  7. Update: Biological Nitrogen Fixation.

    ERIC Educational Resources Information Center

    Wiseman, Alan; And Others

    1985-01-01

    Updates knowledge on nitrogen fixation, indicating that investigation of free-living nitrogen-fixing organisms is proving useful in understanding bacterial partners and is expected to lead to development of more effective symbioses. Specific areas considered include biochemistry/genetics, synthesis control, proteins and enzymes, symbiotic systems,…

  8. SEI: An update

    NASA Technical Reports Server (NTRS)

    Peach, Lewis L., Jr.

    1991-01-01

    An update on the Space Exploration Initiative (SEI) is given in viewgraph form. Topics covered include the key prerequisites of human exploration, project planning, Mars and lunar explorations, supporting technologies, near-term strategies for SEI, human support elements, and Space Station Freedom SEI accommodations.

  9. Community Update, 1999.

    ERIC Educational Resources Information Center

    Anderson, Julie, Ed.

    1999-01-01

    This document consists of nine issues (covering January through December 1999) of the newsletter "Community Update," containing articles on community and family involvement in education. Article topics include: new programs to help students prepare for college early; Vice President Al Gore announced the first-ever national Hispanic Education…

  10. Cultural practices updates

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cultural practice updates from 2013 included the effects of shredding in spring, residue management, periodic flooding, no-till fertilizer applications, and billet planting on cane tonnage and sugar yield. Shredding, whether high or low, had little impacts in 2013. However, burning following shreddi...

  11. Community Update, 2001.

    ERIC Educational Resources Information Center

    Ashby, Nicole, Ed.

    2001-01-01

    This document consists of 10 issues (covering January through December 2000) of the newsletter, "Community Update," which features articles on community and family involvement in education. In addition to the articles, each issue (except the Special Issue) includes a preview of the month's Satellite Town Meeting; events and information discussed…

  12. The X-33 Program Update

    NASA Technical Reports Server (NTRS)

    Dill, Charlie

    2000-01-01

    This viewgraph presentation gives an overview of the X-33 program update, including details on program objectives and plans, the X-33 configuration, technologies used, and X-33 assembly and test status.

  13. ISS Update: Transit of Venus

    NASA Video Gallery

    ISS Update commentator Brandi Dean interviews Mario Runco, NASA astronaut, about Venus's transit across the sun on June 5, 2012. Questions? Ask us on Twitter @NASA_Johnson and include the hashtag #...

  14. Update on gastric varices

    PubMed Central

    Triantafyllou, Maria; Stanley, Adrian J

    2014-01-01

    Although less common than oesophageal variceal haemorrhage, gastric variceal bleeding remains a serious complication of portal hypertension, with a high associated mortality. In this review we provide an update on the aetiology, classification and management of gastric varices, including acute bleeding, prevention of rebleeding and primary prophylaxis. We describe the optimum management strategies for gastric varices including drug, endoscopic and radiological therapies, focusing on recent published evidence. PMID:24891929

  15. Rhabdomyolysis updated

    PubMed Central

    Efstratiadis, G; Voulgaridou, A; Nikiforou, D; Kyventidis, A; Kourkouni, E; Vergoulas, G

    2007-01-01

    Rhabdomyolysis constitutes a common cause of acute renal failure and presents paramount interest. A large variety of causes with different pathogenetic mechanisms can involve skeletal muscles resulting in rhabdomyolysis with or without acute renal failure. Crush syndrome, one of the most common causes of rhabdomyolysis presents increased clinical interest, particularly in areas often involved by earthquakes, such as Greece and Turkey. Drug abusers are another sensitive group of young patients prone to rhabdomyolysis, which attracts the clinical interest of a variety of medical specialties. We herein review the evidence extracted from updated literature concerning the data related to pathogenetic mechanisms and pathophysiology as well as the management of this interesting syndrome. PMID:19582207

  16. [Pharmacovigilance update].

    PubMed

    Livio, F

    2013-01-01

    Main pharmacovigilance updates in 2012 are reviewed here. Dabigatran: elderly patients with renal failure are at higher risk of bleeding. Dual renin-angiotensin-aldosterone system blockade comprising aliskiren is harmful. Incretins: low risk of acute pancreatitis. Interaction between fusidic acid and statins: many reports of rhabdomyolysis. Interactions between boceprevir/telaprevir and antiretroviral therapies: complex, but manageable. Citalopram, ondansetron: maximum recommended doses are reduced. Atomoxetine: significant increase in blood pressure and heart rate in a fraction of exposed patients. Agomelatine: elevated liver enzymes are common. Fingolimod: bradycardia and heart blocks after first dose - stronger safety recommendations regarding use in patients with heart conditions and strengthened cardiovascular monitoring. PMID:23367709

  17. [Pharmacovigilance update].

    PubMed

    Dao, Kim; Chtioui, Haithem; Rothuizen, Laura E; Diezi, Léonore; Prod'hom, Sylvain; Winterfeld, Ursula; Buclin, Thierry; Livio, Françoise

    2016-01-13

    The main pharmacovigilance updates in 2015are reviewed. Sofosbuvir amiodarone interaction: risk of severe bradycardia. Dasabuvir clopidogrel interaction: increased dasabuvir concentrations and potential risk of QTprolongation. SGLT2 inhibitors: risks of diabetic acidocetosis and bone fracture. Dabigatran: therapeutic drug monitoring may improve benefit-risk ratio. Ibuprofen: at higher dosage, vascular risks are comparable to coxibs. Pregabaline, gabapentine: potential for abuse and addiction. Varenicline: potentiates alcohol's effects. Codeine: contra-indicated as cough medicine under the age of twelve. Valproate: strengthened warnings on the risks of valproate use in pregnancy. Dimethylfumarate: rare observations of progressive multifocal leucoencephalopathy. Ustekinumab: rare observations of erythrodermia. PMID:26946710

  18. Working Memory Updating as a Predictor of Academic Attainment

    ERIC Educational Resources Information Center

    Lechuga, M. Teresa; Pelegrina, Santiago; Pelaez, Jose L.; Martin-Puga, M. Eva; Justicia, M. Jose

    2016-01-01

    There is growing evidence supporting the importance of executive functions, and specifically working memory updating (WMU), for children's academic achievement. This study aimed to assess the specific contribution of updating to the prediction of academic performance. Two updating tasks, which included different updating components, were…

  19. RESRAD update

    SciTech Connect

    Yu, C.; Cheng, J.J.; Zielen, A.J.; Jones, L.G.; LePoire, D.J.; Wang, Y.Y. ); Yuan, Y.C. ); Loureiro, C.O. . Escola de Engenharia); Wallo, A. III; Peterson, H. . Offic

    1993-01-01

    A microcomputer program called RESRAD, which implements a pathway analysis method for radiological risk assessment, was developed by Argonne National Laboratory (ANL) in 1989. This program is used to derive allowable residual concentrations of radionuclides in soil and to predict effective dose equivalents and excess cancer incidence risks incurred by an individual exposed to radioactive materials. Since its development, the RESRAD code has been adopted by DOE in Order 5400.5 for the derivation of soil cleanup criteria and dose calculations, and it has been used widely by DOE, other agencies, and their contractors. The original models used by ANL to develop RESRAD were initially developed as part of a DOE effort that began in the early 1980s and involved most of the national laboratories and DOE program offices. The RESRAD code is continuously improved and updated to incorporate comments from users and new features that ease the interaction with users and increase the code's capability and flexibility. The DOE Offices of Environmental Guidance and Environmental Restoration also provide periodic guidance regarding any significant changes to the code. The RESRAD update, Version 5.0, has substantial improvements in many aspects compared with the last version released in 1989.

  20. RESRAD update

    SciTech Connect

    Yu, C.; Cheng, J.J.; Zielen, A.J.; Jones, L.G.; LePoire, D.J.; Wang, Y.Y.; Yuan, Y.C.; Loureiro, C.O.; Wallo, A. III; Peterson, H.; H Williams, W.A.

    1993-05-01

    A microcomputer program called RESRAD, which implements a pathway analysis method for radiological risk assessment, was developed by Argonne National Laboratory (ANL) in 1989. This program is used to derive allowable residual concentrations of radionuclides in soil and to predict effective dose equivalents and excess cancer incidence risks incurred by an individual exposed to radioactive materials. Since its development, the RESRAD code has been adopted by DOE in Order 5400.5 for the derivation of soil cleanup criteria and dose calculations, and it has been used widely by DOE, other agencies, and their contractors. The original models used by ANL to develop RESRAD were initially developed as part of a DOE effort that began in the early 1980s and involved most of the national laboratories and DOE program offices. The RESRAD code is continuously improved and updated to incorporate comments from users and new features that ease the interaction with users and increase the code`s capability and flexibility. The DOE Offices of Environmental Guidance and Environmental Restoration also provide periodic guidance regarding any significant changes to the code. The RESRAD update, Version 5.0, has substantial improvements in many aspects compared with the last version released in 1989.

  1. Initial Business Case Analysis of Two Integrated Heat Pump HVAC Systems for Near-Zero-Energy Homes -- Update to Include Analyses of an Economizer Option and Alternative Winter Water Heating Control Option

    SciTech Connect

    Baxter, Van D

    2006-12-01

    . Eleven system concepts with central air distribution ducting and nine multi-zone systems were selected and their annual and peak demand performance estimated for five locations: Atlanta (mixed-humid), Houston (hot-humid), Phoenix (hot-dry), San Francisco (marine), and Chicago (cold). Performance was estimated by simulating the systems using the TRNSYS simulation engine (Solar Energy Laboratory et al. 2006) in two 1800-ft{sup 2} houses--a Building America (BA) benchmark house and a prototype NZEH taken from BEopt results at the take-off (or crossover) point (i.e., a house incorporating those design features such that further progress towards ZEH is through the addition of photovoltaic power sources, as determined by current BEopt analyses conducted by NREL). Results were summarized in a project report, HVAC Equipment Design options for Near-Zero-Energy Homes--A Stage 2 Scoping Assessment, ORNL/TM-2005/194 (Baxter 2005). The 2005 study report describes the HVAC options considered, the ranking criteria used, and the system rankings by priority. In 2006, the two top-ranked options from the 2005 study, air-source and ground-source versions of an integrated heat pump (IHP) system, were subjected to an initial business case study. The IHPs were subjected to a more rigorous hourly-based assessment of their performance potential compared to a baseline suite of equipment of legally minimum efficiency that provided the same heating, cooling, water heating, demand dehumidification, and ventilation services as the IHPs. Results were summarized in a project report, Initial Business Case Analysis of Two Integrated Heat Pump HVAC Systems for Near-Zero-Energy Homes, ORNL/TM-2006/130 (Baxter 2006). The present report is an update to that document. Its primary purpose is to summarize results of an analysis of the potential of adding an outdoor air economizer operating mode to the IHPs to take advantage of free cooling (using outdoor air to cool the house) whenever possible. In addition it

  2. Exploration Update

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Delores Beasley, NASA Public Affairs, introduces the panel who consist of: Scott "Doc" Horowitz, Associate Administrator of Exploration Systems from NASA Headquarters; Jeff Henley, Constellation Program Manager from NASA Johnson Space Flight Center; and Steve Cook, Manager Exploration Launch Office at NASA Marshall Space Flight Center. Scott Horowitz presents a short video entitled, "Ares Launching the Future". He further explains how NASA personnel came up with the name of Ares and where the name Ares was derived. Jeff Henley, updates the Constellation program and Steve Cook presents two slide presentations detailing the Ares l crew launch vehicle and Ares 5 cargo launch vehicle. A short question and answer period from the news media follows.

  3. [Pharmacovigilance update].

    PubMed

    Diezi, Léonore; Renard, Delphine; Rothuizen, Laura E; Livio, Françoise

    2014-01-15

    The main pharmacovigilance updates in 2013 are reviewed. Nitrofurantoin: lower efficacy and an increased risk of adverse events when creatinine clearance is below 60 ml/min. Dabigatran: contraindicated in patients with mechanical heart valves. Azithromycin: QT prolongation and increased risk of death. Zolpidem: towards a lower dosage. Roflumilast: avoid in patients known or at risk for mood disorders. Retigabine: indication restricted to last-line use and new monitoring requirements after reports of pigment changes in retina and other tissues. Telaprevir and rituximab: severe mucocutaneous reactions. Fingolimod: rare cases of progressive multifocal leucoencephalopathy. Tolvaptan: potential for hepatotoxicity. Nicotinic acid/laropiprant: suspension of marketing authorization as benefits no longer outweigh risks. PMID:24558915

  4. STS-51-L Recovered Debris (Orbiter)

    NASA Technical Reports Server (NTRS)

    1986-01-01

    On January 28, 1986, the Space Shuttle Challenger and her seven-member crew were lost when a ruptured O-ring in the right Solid Rocket Booster caused an explosion soon after launch. After the accident, search and recovery teams worked for months to bring debris from Shuttle to impoundment areas at the Kennedy Space Center and the Cape Canaveral Air Force Station, where reconstruction teams separated the pieces of the orbiter from those of the External Tank and the Solid Rocket Boosters. Taped squares on the floor turned the impoundment areas into a grid in which the reconstruction teams could piece together the Shuttle debris like a puzzle with many missing segments. Shown here is the reassembled Orbiter.

  5. Sensors, Update 12

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Fedder, Gary K.; Korvink, Jan G.

    2003-04-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  6. Sensors, Update 8

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    2001-02-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections: Sensor Technology reviews highlights in applied and basic research, while Sensor Applications covers new or improved applications of sensors, and Sensor Markets provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be invaluable to scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  7. Sensors, Update 2

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    1996-10-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Furthermore, the sensor market as well as peripheral aspects such as standards are covered. Each volume is divided into four sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  8. Sensors, Update 11

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Fedder, Gary K.; Korvink, Jan G.

    2003-03-01

    Sensors Update ensures that you stay at the cutting edge of the field, presenting the current highlights of sensor and related microelectromechanical systems technology. Coverage includes most recent developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles based on micro- and nanotechnology. Each volume is divided into three sections: Sensor Technology reviews highlights in applied and basic research, Sensor Applications covers new or improved applications of sensors and Sensor Markets provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update is of must-have value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  9. Sensors, Update 1

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    1996-12-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Treatments include current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Furthermore, the sensor market as well as peripheral aspects such as standards are covered. Each volume is divided into four sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides an overview of suppliers and market trends for a particular section, and Sensor Standards, reviews recent legislation and requirements for sensors. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  10. Sensors, Update 10

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Fedder, Gary K.; Korvink, Jan G.

    2002-04-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  11. Sensors, Update 9

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    2001-10-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  12. SIM-Lite Update

    NASA Technical Reports Server (NTRS)

    Shao, Michael

    2008-01-01

    Discussion focus on: SIM-Lite Instrument Update - 6m baseline, 50cm, approximately 900M cost; Technology Update - Systematic errors and floor; SIM-Lite terrestrial planet discovery capability; Double blind multiple planet study summary; and the changing landscape of exoplanet science and the role of SIM-Lite. Slides include technology to flight component engineering; instrumental systematic errors; ultra deep search for Earth clones; double blind test, astrometric detection of Earths in multiplanet systems; the current era of exoplanet science and where SIM-Lite fits in; the next frontier and where SIM-Lite fits in, why SIM is unique in discovering Earths; imaging planet status is uncertain without masses and ages; SIM role in establishing how planetary systems form and evolve; and SIM probes of broad planet mass range around young stars.

  13. Activities update

    NASA Astrophysics Data System (ADS)

    Smith, Gerald A.

    1994-07-01

    The present report is an update on activities for the second year of funding. Research leading to a detailed characterization of antiproton annihilation in nuclei has resulted in a published analysis of fast deuteron production from carbon and uranium targets. This follows previously reported work and publications by our group on gamma-ray, neutral and charged pion, proton, and neutron production. The deuteron measurements are important to our SHIVA Star antiproton- catalyzed microfission experiment at the Phillips Laboratory, Kirtland AFB, in that they help constrain theoretical models of light nuclei production and subsequent energy deposition in the target. Work continues at SHIVA Star on working fluid formation and target compression for the microfission experiment. Excellent progress has been made, both theoretically and experimentally, on these important aspects of the experiment. The Penn State group, working in collaboration with Los Alamos National Laboratory physicists, trapped and held up to 721,000 antiprotons per beam injection pulse from the LEAR accelerator during July, 1993. This was a crucial step to the ultimate goal of transferring large numbers of antiprotons to the Phillips Laboratory for the antiproton-catalyzed microfission experiment.

  14. Updated keys to the genera in the subfamilies of Cyclocoelidae Stossich, 1902, including a reconsideration of species assignments, species keys and the proposal of a new genus in Szidatitreminae Dronen, 2007.

    PubMed

    Dronen, Norman O; Blend, Charles K

    2015-01-01

    Keys to the six subfamilies, 22 genera within subfamilies and 128 species recognized within the Cyclocoelidae are provided. Lists of species in each genus are provided, along with taxonomic summaries that include type host, type locality, additional hosts, additional localities, previously proposed synonyms, and remarks for each species. The following synonymies are proposed: Cyclocoelum mutabile (Zeder, 1800)-Syn. C. microstomum (Creplin, 1929); Cyclocoelum leidyi Harrah, 1922-Syn. C. cuneatum Harrah, 1922; Cyclocoelum mehrotrai Sinha & Sahay, 1975-Syn. C. mathuri Jain, 1984; Selfcoelum allahabadi (Khan, 1935) n. comb.-Syns. Cyclocoelum agamprasadi Jain, 1983, Cyclocoelum erythropis Khan, 1935 and Cyclocoelum indicum Khan, 1935; Selfcoelum obliquum (Harrah, 1921) n. comb.-Syn. Cyclocoelum mehrii Khan, 1935; Uvitellina adelphus (Johnston, 1917)-Syn. Cyclocoelum (Uvitellina) dollfusi Tseng, 1930; Uvitellina kaniharensis (Gupta, 1958)-Syn. U. indica Siddiqi & Jairajpuri, 1962; Uvitellina simile (Stossich, 1902) n. comb.-Syn. U. magniembria Witenberg, 1923; Uvitellina vanelli (Rudolphi, 1819)-Syns. U. keri Yamaguti, 1933 and U. tageri Yamaguti, 1933; Wardianum triangulare (Harrah, 1922)-Syn. Wardianum catoptrophori Dronen, 2007; Haematotrephus limnodromi Dronen, Gardner & Jiménez, 2006-Syn. H. selfi Dronen, Gardner & Jiménez, 2008; and Hyptiasmus arcuatus (Brandes, 1892 of Stossich, 1902)-Syn. H. coelonodus Witenberg, 1923. Based on the lack of adequate descriptive information, Cyclocoelum cornu (Zeder, 1800); Cyclocoelum crenulatum (Rudolphi, 1809); Haematotrephus nigropunctatum (von Linstow, 1883) n. comb.; Haematotrephus robustus Ukoli, 1968; Hyptiasmus californicus (Wootton, 1966); and Hyptiasmus vigisi Savinov, 1960 are considered to be species inquirendae. Hyptiasmus witenbergi Tret'iakova, 1940 (described in a dissertation) is considered to be a nomen nudum. Comparative tables containing measurements, morphometric percentages and morphometric ratios for

  15. Energy Education Materials Bibliography - Update.

    ERIC Educational Resources Information Center

    Minnesota State Energy Agency, St. Paul.

    Presented is an updated version of a previous bibliography prepared by the Minnesota State Energy Agency. The materials included in this document are indexed according to grade level and according to whether they are background materials or classroom activities. Each of the items listed were evaluated and included into either the "A" list or the…

  16. A multi-stage genome-wide association in breast cancer identifies two novel risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

    PubMed Central

    Thomas, Gilles; Jacobs, Kevin B.; Kraft, Peter; Yeager, Meredith; Wacholder, Sholom; Cox, David G.; Hankinson, Susan E.; Hutchinson, Amy; Wang, Zhaoming; Yu, Kai; Chatterjee, Nilanjan; Garcia-Closas, Montserrat; Gonzalez-Bosquet, Jesus; Prokunina-Olsson, Ludmila; Orr, Nick; Willett, Walter C.; Colditz, Graham A.; Ziegler, Regina G.; Berg, Christine D.; Buys, Saundra S.; McCarty, Catherine A.; Feigelson, Heather Spencer; Calle, Eugenia E.; Thun, Michael J.; Diver, Ryan; Prentice, Ross; Jackson, Rebecca; Kooperberg, Charles; Chlebowski, Rowan; Lissowska, Jolanta; Peplonska, Beata; Brinton, Louise A.; Sigurdson, Alice; Doody, Michele; Bhatti, Parveen; Alexander, Bruce H.; Buring, Julie; Lee, I-Min; Vatten, Lars J; Hveem, Kristian; Kumle, Merethe; Hayes, Richard B.; Tucker, Margaret; Gerhard, Daniela S.; Fraumeni, Joseph F.; Hoover, Robert N.; Chanock, Stephen J; Hunter, David J.

    2010-01-01

    The Cancer Genetic Markers of Susceptibility (CGEMS) initiative has conducted a three-stage genome-wide association study (GWAS) of breast cancer in 9,770 cases and 10,799 controls. In Stage 1, we genotyped 528,173 single nucleotide polymorphisms (SNPs) in 1,145 cases of invasive breast cancer among postmenopausal white women, and 1,142 controls; in Stage 2, 24,909 SNPs with low p values observed in Stage 1 were analyzed in 4,547 cases and 4,434 controls. In Stage 3 we investigated 21 loci in 4,078 cases and 5,223 controls with low p values from Stage 1 and 2 combined. Two novel loci achieved genome-wide significance. A pericentromeric SNP on chromosome 1p11.2, rs11249433, (p=6.74 × 10-10 adjusted genotype test with 2 degrees of freedom) resides in a large block of linkage disequilibrium neighboring NOTCH2 and FCGR1B and is predominantly associated with estrogen receptor-positive breast cancer. A second SNP, rs999737 on chromosome 14q24.1 (p=1.74 × 10−7), localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway, a prior candidate pathway for breast cancer susceptibility. We confirmed previously reported markers on chromosome 2q35, 5q11.2, 5p12, 8q24, 10q26, and 16q12.1. Our results underscore the importance of large-scale replication in the identification of low penetrance breast cancer alleles. PMID:19330030

  17. Legislative Update, June 2010. Report 10-13

    ERIC Educational Resources Information Center

    Blair, Julia

    2010-01-01

    This update contains analyses of legislation being tracked by California Postsecondary Education Commission (CPEC) staff. It has updated positions on bills as adopted in the Commission meeting on June 8. A matrix of bills tracked by CPEC staff is included.

  18. Rebuild America partner update, November--December 1998

    SciTech Connect

    1998-11-01

    This issue of the update includes articles on retrofitting Duke University facilities, energy efficiency updates to buildings in Portland, Oregon, Salisbury, North Carolina, Hawaii, Roanoke-Chowan, Virginia, and energy savings centered designs for lighting systems.

  19. Updated Conceptual Cost Estimating

    NASA Technical Reports Server (NTRS)

    Brown, J. A.

    1987-01-01

    16-page report discusses development and use of NASA TR-1508, the Kennedy Space Center Aerospace Construction Price Book for preparing conceptual, budget, funding, cost-estimating, and preliminary cost-engineering reports. Updated annually from 1974 through 1985 with actual bid prices and government estimates. Includes labor and material quantities and prices with contractor and subcontractor markups for buildings, facilities, and systems at Kennedy Space Center. While data pertains to aerospace facilities, format and cost-estimating techniques guide estimation of costs in other construction applications.

  20. Part C Updates. 10th Edition

    ERIC Educational Resources Information Center

    Goode, Sue; Lazara, Alex; Danaher, Joan

    2008-01-01

    "Part C Updates" is a compilation of information on various aspects of the Early Intervention Program for Infants and Toddlers with Disabilities (Part C) of the Individuals with Disabilities Education Act (IDEA). This is the tenth volume in a series of compilations, which included two editions of Part H Updates, the former name of the program.…

  1. 75 FR 17641 - Updating Fire Safety Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    ... AFFAIRS 38 CFR Parts 17 and 59 RIN 2900-AN57 Updating Fire Safety Standards AGENCY: Department of Veterans..., including standards for fire safety and heating and cooling systems. The proposed amendments would help.... Comments should indicate that they are submitted in response to ``RIN 2900-AN57--Updating Fire...

  2. Census in Schools Educator Update, February 2010

    ERIC Educational Resources Information Center

    US Census Bureau, 2010

    2010-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter includes the following items: (1) Have You Seen the Census…

  3. Part C Updates. 11th Edition

    ERIC Educational Resources Information Center

    Danaher, Joan; Goode, Sue; Lazara, Alex

    2010-01-01

    "Part C Updates" is a compilation of information on various aspects of the Early Intervention Program for Infants and Toddlers with Disabilities (Part C) of the Individuals with Disabilities Education Act (IDEA). This is the eleventh volume in a series of compilations, which included two editions of Part H Updates, the former name of the program.…

  4. UPDATE: Applications of Research in Music Education. UPDATE Yearbook

    ERIC Educational Resources Information Center

    Rowman & Littlefield Education, 2005

    2005-01-01

    The Fall 2004 and Spring 2005 issues of "UPDATE: Applications of Research in Music Education," in one print volume, presents hard facts and statistical data in a style that can be easily understood and appreciated by music researchers, teachers, graduates, and undergraduates alike. Includes advice to first-year music teachers, instrument…

  5. LDEF environment modeling updates

    NASA Technical Reports Server (NTRS)

    Gordon, Tim; Rantanen, Ray; Whitaker, Ann F.

    1995-01-01

    An updated gas dynamics model for gas interactions around the LDEF is presented that includes improved scattering algorithms. The primary improvement is more accurate predictions of surface fluxes in the wake region. The code used is the Integrated Spacecraft Environments Model (ISEM). Additionally, initial results of a detailed ISEM prediction model of the Solar Array Passive LDEF Experiment (SAMPLE), A0171, is presented. This model includes details of the A0171 geometry and outgassing characteristics of the many surfaces on the experiment. The detailed model includes the multiple scattering that exists between the ambient atmosphere, LDEF outgassing, and atomic oxygen erosion products. Predictions are made for gas densities, surface fluxes and deposition at three different time periods of the LDEF mission.

  6. Neuroanesthesiology update.

    PubMed

    Pasternak, Jeffrey J; Lanier, William L

    2014-04-01

    We review topics pertinent to the perioperative care of patients with neurological disorders. Our review addresses topics not only in the anesthesiology literature, but also in basic neurosciences, critical care medicine, neurology, neurosurgery, radiology, and internal medicine literature. We include literature published or available online up through December 8, 2013. As our review is not able to include all manuscripts, we focus on recurring themes and unique and pivotal investigations. We address the broad topics of general neuroanesthesia, stroke, traumatic brain injury, anesthetic neurotoxicity, neuroprotection, pharmacology, physiology, and nervous system monitoring. PMID:24594653

  7. Propane Update.

    ERIC Educational Resources Information Center

    Brantner, Max

    1984-01-01

    Reports on a northern Illinois school bus fleet converted to propane fuel in 1981 and 1982. Includes tables showing, first, total annual fuel costs before and after conversion and, second, fuel efficiency for 16 buses using propane and three using gasoline. Notes precautions for propane use. (MCG)

  8. Updating Systematic Reviews: An International Survey

    PubMed Central

    Garritty, Chantelle; Tsertsvadze, Alexander; Tricco, Andrea C.; Sampson, Margaret; Moher, David

    2010-01-01

    Background Systematic reviews (SRs) should be up to date to maintain their importance in informing healthcare policy and practice. However, little guidance is available about when and how to update SRs. Moreover, the updating policies and practices of organizations that commission or produce SRs are unclear. Methodology/Principal Findings The objective was to describe the updating practices and policies of agencies that sponsor or conduct SRs. An Internet-based survey was administered to a purposive non-random sample of 195 healthcare organizations within the international SR community. Survey results were analyzed using descriptive statistics. The completed response rate was 58% (n = 114) from across 26 countries with 70% (75/107) of participants identified as producers of SRs. Among responders, 79% (84/107) characterized the importance of updating as high or very-high and 57% (60/106) of organizations reported to have a formal policy for updating. However, only 29% (35/106) of organizations made reference to a written policy document. Several groups (62/105; 59%) reported updating practices as irregular, and over half (53/103) of organizational respondents estimated that more than 50% of their respective SRs were likely out of date. Authors of the original SR (42/106; 40%) were most often deemed responsible for ensuring SRs were current. Barriers to updating included resource constraints, reviewer motivation, lack of academic credit, and limited publishing formats. Most respondents (70/100; 70%) indicated that they supported centralization of updating efforts across institutions or agencies. Furthermore, 84% (83/99) of respondents indicated they favoured the development of a central registry of SRs, analogous to efforts within the clinical trials community. Conclusions/Significance Most organizations that sponsor and/or carry out SRs consider updating important. Despite this recognition, updating practices are not regular, and many organizations lack a formal

  9. Community Update, 1998-1999.

    ERIC Educational Resources Information Center

    Anderson, Julie, Ed.

    1999-01-01

    This document consists of ten issues of the newsletter "Community Update," containing articles on community and family involvement in education. Article topics include: a college education is necessary and possible; math and science study points out problems and positive solutions; the "America Reads Challenge"; meeting the Department of…

  10. Community Update, 1997-1998.

    ERIC Educational Resources Information Center

    Anderson, Julie, Ed.

    1998-01-01

    This document consists of 10 issues of the newsletter "Community Update," containing articles on community and family involvement in education. Article topics include: preparing America's future teachers; reports on satellite town meetings; E-rate (education rate) discounts for telecommunications services in schools and libraries; President…

  11. Wind turbine reliability database update.

    SciTech Connect

    Peters, Valerie A.; Hill, Roger Ray; Stinebaugh, Jennifer A.; Veers, Paul S.

    2009-03-01

    This report documents the status of the Sandia National Laboratories' Wind Plant Reliability Database. Included in this report are updates on the form and contents of the Database, which stems from a fivestep process of data partnerships, data definition and transfer, data formatting and normalization, analysis, and reporting. Selected observations are also reported.

  12. Updating the Behavior Engineering Model.

    ERIC Educational Resources Information Center

    Chevalier, Roger

    2003-01-01

    Considers Thomas Gilbert's Behavior Engineering Model as a tool for systematically identifying barriers to individual and organizational performance. Includes a detailed case study and a performance aid that incorporates gap analysis, cause analysis, and force field analysis to update the original model. (Author/LRW)

  13. ERIC/IT Update, 2002.

    ERIC Educational Resources Information Center

    ERIC/IT Update, 2002

    2002-01-01

    This document contains two issues of the ERIC Clearinghouse on Information and Technology (ERIC/IT) serial publication, "Update." Each issue includes feature articles; ERIC/IT News; information about new books published in cooperation with ERIC/IT; abstracts of new ERIC Digests, with links to full-text versions of the Digests; a subscription form;…

  14. Updating Situation Models

    ERIC Educational Resources Information Center

    Zwaan, Rolf A.; Madden, Carol J.

    2004-01-01

    The authors examined how situation models are updated during text comprehension. If comprehenders keep track of the evolving situation, they should update their models such that the most current information, the here and now, is more available than outdated information. Contrary to this updating hypothesis, E. J. O'Brien, M. L. Rizzella, J. E.…

  15. Cysticercosis Update

    PubMed Central

    Grisolia, James Santiago

    1984-01-01

    Already the most common brain parasite disease, cysticercosis has been increasingly seen throughout the American Southwest. Symptoms arise from infection with larvae of Taenia solium, the pork tapeworm. Seizures, hydrocephalus, focal deficits and chronic meningitis most commonly result. Cerebrospinal fluid eosinophilia, serology by indirect hemagglutination and computed tomography are helpful adjuncts to diagnosis. New evidence suggests that selective immunosuppression is important for the parasites' survival and that cyst death permits renewed host immunity, which may actually precipitate an acute neurologic presentation. New larvicides, including praziquantel, are being tested in humans; caution is indicated in assessing these drugs because of the acute worsening associated with cyst death. Conventional therapy includes anticonvulsants, steroids or ventricular drainage as needed. Prevention remains the best management. Person-to-person transmission within the United States has recently been documented and merits public health scrutiny. PMID:6377706

  16. Update on local allergic rhinitis.

    PubMed

    Altıntoprak, Niyazi; Kar, Murat; Bayar Muluk, Nuray; Oktemer, Tugba; Ipci, Kagan; Birdane, Leman; Aricigil, Mitat; Senturk, Mehmet; Bafaqeeh, Sameer Ali; Cingi, Cemal

    2016-08-01

    We here provide an update on the literature regarding local allergic rhinitis (LAR). In reviewing LAR, we have included an updated definition, classifications, mechanisms, comorbidities, and recommendations for diagnosis and treatment for LAR, as well as the defined research areas for future evidence-based studies. LAR is a localised nasal allergic response in the absence of systemic atopy characterised by local production of specific IgE (sIgE) antibodies, a TH2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response, with the release of inflammatory mediators. The localised allergic response of LAR is an important topic for the study of allergies. This review provides an update on the current knowledge of LAR. PMID:27368453

  17. Macrofouling control technology update

    SciTech Connect

    Tsou, J.L.; Armor, A.F.

    1996-12-31

    Macrofouling of condenser systems with debris, fish, clams, barnacles, mussels, algae, and other marine organisms can significantly affect power plant availability and performance. Typical difficulties include increased condenser back pressure due to reduced cooling-water flow, malfunctioning of on-line tube-cleaning equipment, and accelerated corrosion and erosion of tubing. In some severe cases, condenser back pressure increased to a point that the turbine had to be tripped. In 1981 EPRI initiated a research project to develop utility industry guidelines for reducing macrofouling problems. In 1987 EPRI published the Guidelines on Macrofouling Control Technology. Since then significant progress has been made by EPRI, utility members, equipment manufacturers, and others. The purpose of this paper is to update the macrofouling control technology. Control technology covered will include thermal treatment, mechanical removal devices, antifouling coatings, and chemical treatment.

  18. Neurocritical care update.

    PubMed

    Kuroda, Yasuhiro

    2016-01-01

    This update comprises six important topics under neurocritical care that require reevaluation. For post-cardiac arrest brain injury, the evaluation of the injury and its corresponding therapy, including temperature modulation, is required. Analgosedation for target temperature management is an essential strategy to prevent shivering and minimizes endogenous stress induced by catecholamine surges. For severe traumatic brain injury, the diverse effects of therapeutic hypothermia depend on the complicated pathophysiology of the condition. Continuous electroencephalogram monitoring is an essential tool for detecting nonconvulsive status epilepticus in the intensive care unit (ICU). Neurocritical care, including advanced hemodynamic monitoring, is a fundamental approach for delayed cerebral ischemia following subarachnoid hemorrhage. We must be mindful of the high percentage of ICU patients who may develop sepsis-associated brain dysfunction. PMID:27239312

  19. [Histoplasmosis updating].

    PubMed

    Fernández Andreu, C Carlos M; Illnait Zaragozi, María T; Martínez Machín, Gerardo; Perurena Lancha, Mayda R; Monroy Vaca, Ernesto

    2011-01-01

    Histoplasmosis, an infection caused by the fungus Histoplasma capsulatum, has been reported all over the world and is considered endemic in the American continent, including Cuba. This fungus grows on the soils contaminated with bird and bat excreta, where it produces a great number of microconidia that could cause the infection when they are inhaled. The clinical spectrum varies from asymptomatic infections to serious disseminated diseases involving one or many organ systems and affects mainly AIDS patients, patients with hematological neoplasias, transplant recipients or other immunosuppressed patients. The main risk groups include those individuals whose working activities make them be exposed to aerosols contaminated with H. capsulatum. Lab diagnosis is based on the microscopic observation, isolation and identification of the fungus in fluid or tissue samples of patients, and on specific antigen and antibodies detection. The molecular methods based on polymerase chain reaction have not been sufficiently defined, and they could be an important advance in the early diagnosis of this mycosis. Itraconazole is recommended for treatment of moderate, localized and chronic infection whereas amphotericin B is the drug of choice for disseminated and serious manifestations, particularly in its lipidic formulations. At present, histoplasmosis is considered one of the most important systemic mycoses in the Americas, and it is widely spread over all regions of Cuba. PMID:23444607

  20. Ebola Update.

    PubMed

    O'Keefe, Louise C

    2016-01-01

    The Ebola virus disease first appeared in 1976 in the Sudan and the Democratic Republic of Congo. The most recent outbreak occurred in West Africa in March 2014 and quickly spread in surrounding countries. Ebola spreads through direct contact with the body fluids of an infected individual. The incubation period for Ebola is 2 to 21 days. Individuals are infectious when symptomatic. Identifying individuals at high risk for Ebola in the United States includes early recognition of symptoms and a history of travel to an Ebola-affected area. Multiple diagnostic tests exist and should include a complete blood count and a comprehensive metabolic profile. Standard, contact, and droplet precautions are advised when taking care of patients with Ebola. Appropriate personal protective equipment as recommended by the Centers for Disease Control and Prevention should be worn. No vaccine or antiviral drug has been approved, but vaccine trials are under way. Occupational health nurses play a key role in educating employees about this disease. PMID:26419541

  1. Melasma update

    PubMed Central

    Sarkar, Rashmi; Arora, Pooja; Garg, Vijay Kumar; Sonthalia, Sidharth; Gokhale, Narendra

    2014-01-01

    Melasma is an acquired pigmentary disorder characterized by symmetrical hyperpigmented macules on the face. Its pathogenesis is complex and involves the interplay of various factors such as genetic predisposition, ultraviolet radiation, hormonal factors, and drugs. An insight into the pathogenesis is important to devise treatment modalities that accurately target the disease process and prevent relapses. Hydroquinone remains the gold standard of treatment though many newer drugs, especially plant extracts, have been developed in the last few years. In this article, we review the pathogenetic factors involved in melasma. We also describe the newer treatment options available and their efficacy. We carried out a PubMed search using the following terms “melasma, pathogenesis, etiology, diagnosis, treatment” and have included data of the last few years. PMID:25396123

  2. [Antidote update].

    PubMed

    Kiyota, Kazuya

    2016-02-01

    In Japan, several products of the antidote for poisoning have been authorized in clinical use from some recent years. For example, Hydroxcobalamin for cyanide poisoning was introduced in 2008. In 2009, Ministry of Health, Labour and Welfare invited suggestions of demand of pharmaceutical products which is high in the need in the medical care but yet unauthorized. Japanese Society for Clinical Toxicology and Japan Poison Information Center applied some candidates including methyleneblue (MB) and fomepizole, both of them were authorized in clinical market in 2015. MB is the medicine for methemoglobinemia, caused by variety of chemical products such as nitrogen oxide. Fomepizole is the antidote for methanol and ethyleneglycol, blocking alcohol dehydrogenase. PMID:26915245

  3. ISS Update: High Rate Communications System

    NASA Video Gallery

    ISS Update Commentator Pat Ryan interviews Diego Serna, Communications and Tracking Officer, about the High Rate Communications System. Questions? Ask us on Twitter @NASA_Johnson and include the ha...

  4. DOE Wind Program Update: June 4, 2006;

    SciTech Connect

    Not Available

    2006-06-01

    The DOE Wind Program Update provides WindPower Conference attendees with information about recent DOE events, including Assistant Secretary Karsner, a wind turbine blade test facility CRADA, and 2005 Wind Energy Award recipients.

  5. Perinatal neuroprotection update

    PubMed Central

    Jelin, Angie C.; Salmeen, Kirsten; Gano, Dawn; Burd, Irina; Thiet, Mari-Paule

    2016-01-01

    Antepartum, intrapartum, and neonatal events can result in a spectrum of long-term neurological sequelae, including cerebral palsy, cognitive delay, schizophrenia, and autism spectrum disorders [1]. Advances in obstetrical and neonatal care have led to survival at earlier gestational ages and consequently increasing numbers of periviable infants who are at significant risk for long-term neurological deficits. Therefore, efforts to decrease and prevent cerebral insults attempt not only to decrease preterm delivery but also to improve neurological outcomes in infants delivered preterm. We recently published a comprehensive review addressing the impacts of magnesium sulfate, therapeutic hypothermia, delayed cord clamping, infections, and prevention of preterm delivery on the modification of neurological risk [2]. In this review, we will briefly provide updates to the aforementioned topics as well as an expansion on avoidance of toxin and infections, specifically the Zika virus. PMID:27606053

  6. ILRS Website Update

    NASA Technical Reports Server (NTRS)

    Noll, Carey E.; Torrence, Mark H.; Pollack, Nathan H.; Tyahla, Lori J.

    2013-01-01

    The ILRS website, http://ilrs.gsfc.nasa.gov, is the central source of information for all aspects of the service. The website provides information on the organization and operation of the ILRS and descriptions of ILRS components data, and products. Furthermore, the website provides an entry point to the archive of these data products available through the data centers. Links are provided to extensive information on the ILRS network stations including performance assesments and data quality evaluations. Descriptions of suported satellite missions (current, future, and past) are provided to aid in station acquisition and data analysis. The website was reently redesigned. Content was reviewed during the update process, ensuring information is current and useful. This poster will provide specific examples of key sections, applicaitons, and webpages.

  7. Update on infection control.

    PubMed

    1999-12-01

    Infection control is a dynamic and ever-changing subject and all dental staff should be kept aware of the most up-to-date procedures required to prevent the transmission of infection and should understand why these procedures are necessary. Regular monitoring and updating of all procedures in the light of new scientific evidence is necessary and all new staff must be trained in infection control procedures prior to working in the surgery. A practitioner who is routinely following an appropriate infection control policy, including the use of techniques and products of proven efficacy (perhaps through accreditation), is better placed to refute allegations arising in the course of civil litigation, health and safety at work prosecution, complaints and disciplinary procedures, or investigations by the GDC. PMID:16892574

  8. Perinatal neuroprotection update.

    PubMed

    Jelin, Angie C; Salmeen, Kirsten; Gano, Dawn; Burd, Irina; Thiet, Mari-Paule

    2016-01-01

    Antepartum, intrapartum, and neonatal events can result in a spectrum of long-term neurological sequelae, including cerebral palsy, cognitive delay, schizophrenia, and autism spectrum disorders [1]. Advances in obstetrical and neonatal care have led to survival at earlier gestational ages and consequently increasing numbers of periviable infants who are at significant risk for long-term neurological deficits. Therefore, efforts to decrease and prevent cerebral insults attempt not only to decrease preterm delivery but also to improve neurological outcomes in infants delivered preterm. We recently published a comprehensive review addressing the impacts of magnesium sulfate, therapeutic hypothermia, delayed cord clamping, infections, and prevention of preterm delivery on the modification of neurological risk [2]. In this review, we will briefly provide updates to the aforementioned topics as well as an expansion on avoidance of toxin and infections, specifically the Zika virus. PMID:27606053

  9. Updating the Read Codes

    PubMed Central

    Robinson, David; Comp, Dip; Schulz, Erich; Brown, Philip; Price, Colin

    1997-01-01

    Abstract The Read Codes are a hierarchically-arranged controlled clinical vocabulary introduced in the early 1980s and now consisting of three maintained versions of differing complexity. The code sets are dynamic, and are updated quarterly in response to requests from users including clinicians in both primary and secondary care, software suppliers, and advice from a network of specialist healthcare professionals. The codes' continual evolution of content, both across and within versions, highlights tensions between different users and uses of coded clinical data. Internal processes, external interactions and new structural features implemented by the NHS Centre for Coding and Classification (NHSCCC) for user interactive maintenance of the Read Codes are described, and over 2000 items of user feedback episodes received over a 15-month period are analysed. PMID:9391934

  10. Moving Objects Updating

    NASA Astrophysics Data System (ADS)

    Chen, Jidong; Meng, Xiaofeng

    In moving objects applications, large numbers of locations can be sampled by sensors or GPS periodically, then sent from moving clients to the server and stored in a database. Therefore, continuously maintaining in a database the current locations of moving objects by using a tracking technique becomes very important. The key issue is minimizing the number of updates, while providing precise locations for query results. In this chapter, we will introduce some underlying location update methods. Then, we describe two location update strategies in detail, which can improve the performance. One is the proactive location update strategy, which predicts the movement of moving objects to lower the update frequency; the other is the group location update strategy, which groups the objects to minimize the total number of objects reporting their locations.

  11. ISS Update: Suitport

    NASA Video Gallery

    ISS Update commentator Lynnette Madison interviews Mallory Jennings, Suitport Human Testing Lead, about making spacewalks easier and more efficient with the Suitport. Questions? Ask us on Twitter @...

  12. Update in Internal Medicine

    PubMed Central

    López-Jiménez, Francisco; Brito, Máximo; Aude, Y. Wady; Scheinberg, Phillip; Kaplan, Mariana; Dixon, Denise A.; Schneiderman, Neil; Trejo, Jorge F.; López-Salazar, Luis Humberto; Ramírez-Barba, Ector Jaime; Kalil, Roberto; Ortiz, Carmen; Goyos, José; Buenaño, Alvaro; Kottiech, Samer; Lamas, Gervasio A.

    2009-01-01

    More than 500,000 new medical articles are published every year and available time to keep updated is scarcer every day. Nowadays, the task of selecting useful, consistent, and relevant information for clinicians is a priority in many major medical journals. This review has the aim of gathering the results of the most important findings in clinical medicine in the last few years. It is focused on results from randomized clinical trials and well-designed observational research. Findings were included preferentially if they showed solid results, and we avoided as much as possible including only preliminary data, or results that included only non-clinical outcomes. Some of the most relevant findings reported here include the significant benefit of statins in patients with coronary artery disease even with mean cholesterol level. It also provides a substantial review of the most significant trials assessing the effectiveness of IIb/IIIa receptor blockers. In gastroenterology many advances have been made in the H. pylori eradication, and the finding that the cure of H. pylori infection may be followed by gastroesophageal reflux disease. Some new antivirals have shown encouraging results in patients with chronic hepatitis. In the infectious disease arena, the late breaking trials in anti-retroviral disease are discussed, as well as the new trends regarding antibiotic resistance. This review approaches also the role of leukotriene modifiers in the treatment of asthma and discusses the benefit of using methylprednisolone in patients with adult respiratory distress syndrome, among many other advances in internal medicine. PMID:11068074

  13. The template update problem.

    PubMed

    Matthews, Iain; Ishikawa, Takahiro; Baker, Simon

    2004-06-01

    Template tracking dates back to the 1981 Lucas-Kanade algorithm. One question that has received very little attention, however, is how to update the template so that it remains a good model of the tracked object. We propose a template update algorithm that avoids the "drifting" inherent in the naive algorithm. PMID:18579941

  14. Environmental Regulatory Update Table, August 1991

    SciTech Connect

    Houlberg, L.M., Hawkins, G.T.; Salk, M.S.

    1991-09-01

    This Environmental Regulatory Update Table (August 1991) provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  15. Environmental Regulatory Update Table, October 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  16. Environmental Regulatory Update Table, December 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1992-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  17. Environmental Regulatory Update Table, April 1989

    SciTech Connect

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  18. Environmental Regulatory Update Table, November 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-12-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  19. Environmental Regulatory Update Table, December 1989

    SciTech Connect

    Houlbert, L.M.; Langston, M.E. ); Nikbakht, A.; Salk, M.S. )

    1990-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  20. Environmental Regulatory Update Table, September 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-10-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  1. Environmental Regulatory Update Table, December 1990

    SciTech Connect

    Hawkins, G.T.; Houlberg, L.M.; Noghrei-Nikbakht, P.A.; Salk, M.S.

    1991-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  2. Environmental Regulatory Update Table, November 1990

    SciTech Connect

    Hawkins, G.T.; Houlberg, L.M.; Noghrei-Nikbakht, P.A.; Salk, M.S.

    1990-12-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  3. Environmental Regulatory Update Table, October 1990

    SciTech Connect

    Houlberg, L.M.; Noghrei-Nikbakht, P.A.; Salk, M.S.

    1990-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  4. Environmental Regulatory Update Table, September 1990

    SciTech Connect

    Houlberg, L.M.; Nikbakht, A.; Salk, M.S.

    1990-10-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  5. Environmental regulatory update table, July 1991

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-08-01

    This Environmental Regulatory Update Table (July 1991) provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  6. Environmental regulatory update table, March 1989

    SciTech Connect

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-04-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  7. Results of the Updated ACS/WFC Distortion Correction

    NASA Astrophysics Data System (ADS)

    Borncamp, David; Kozhurina-Platais, Vera; Avila, Roberto

    2015-03-01

    We present the results of testing an updated, interim, geometric distortion correction forthe Advanced Camera for Surveys (ACS) Wide Field Channel (WFC). This testing includes not only the updated distortion correction, but also a more robust implementation of the time dependent distortion. The updated geometric distortion correction including this time dependency can greatly improve the accuracy of the image alignment and provides a better representation of the undistorted image by as much as 0.15 pixels at the edge of the chips.

  8. 34 CFR 303.15 - Include; including.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Include; including. 303.15 Section 303.15 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND TODDLERS...

  9. Genomics and Health Impact Update

    MedlinePlus

    ... Genomics in Practice Newborn Screening Pharmacogenomics Reproductive Health Tools and Databases About the Genomics & Health Impact Update The Office of Public Health Genomics provides updated and credible ...

  10. Update on PISCES

    NASA Technical Reports Server (NTRS)

    Pearson, Don; Hamm, Dustin; Kubena, Brian; Weaver, Jonathan K.

    2010-01-01

    An updated version of the Platform Independent Software Components for the Exploration of Space (PISCES) software library is available. A previous version was reported in Library for Developing Spacecraft-Mission-Planning Software (MSC-22983), NASA Tech Briefs, Vol. 25, No. 7 (July 2001), page 52. To recapitulate: This software provides for Web-based, collaborative development of computer programs for planning trajectories and trajectory- related aspects of spacecraft-mission design. The library was built using state-of-the-art object-oriented concepts and software-development methodologies. The components of PISCES include Java-language application programs arranged in a hierarchy of classes that facilitates the reuse of the components. As its full name suggests, the PISCES library affords platform-independence: The Java language makes it possible to use the classes and application programs with a Java virtual machine, which is available in most Web-browser programs. Another advantage is expandability: Object orientation facilitates expansion of the library through creation of a new class. Improvements in the library since the previous version include development of orbital-maneuver- planning and rendezvous-launch-window application programs, enhancement of capabilities for propagation of orbits, and development of a desktop user interface.

  11. Families classification including multiopposition asteroids

    NASA Astrophysics Data System (ADS)

    Milani, Andrea; Spoto, Federica; Knežević, Zoran; Novaković, Bojan; Tsirvoulis, Georgios

    2016-01-01

    In this paper we present the results of our new classification of asteroid families, upgraded by using catalog with > 500,000 asteroids. We discuss the outcome of the most recent update of the family list and of their membership. We found enough evidence to perform 9 mergers of the previously independent families. By introducing an improved method of estimation of the expected family growth in the less populous regions (e.g. at high inclination) we were able to reliably decide on rejection of one tiny group as a probable statistical fluke. Thus we reduced our current list to 115 families. We also present newly determined ages for 6 families, including complex 135 and 221, improving also our understanding of the dynamical vs. collisional families relationship. We conclude with some recommendations for the future work and for the family name problem.

  12. a Bottom-Up Geosptial Data Update Mechanism for Spatial Data Infrastructure Updating

    NASA Astrophysics Data System (ADS)

    Tian, W.; Zhu, X.; Liu, Y.

    2012-08-01

    Currently, the top-down spatial data update mechanism has made a big progress and it is wildly applied in many SDI (spatial data infrastructure). However, this mechanism still has some issues. For example, the update schedule is limited by the professional department's project, usually which is too long for the end-user; the data form collection to public cost too much time and energy for professional department; the details of geospatial information does not provide sufficient attribute, etc. Thus, how to deal with the problems has become the effective shortcut. Emerging Internet technology, 3S technique and geographic information knowledge which is popular in the public promote the booming development of geoscience in volunteered geospatial information. Volunteered geospatial information is the current "hotspot", which attracts many researchers to study its data quality and credibility, accuracy, sustainability, social benefit, application and so on. In addition to this, a few scholars also pay attention to the value of VGI to support the SDI updating. And on that basis, this paper presents a bottom-up update mechanism form VGI to SDI, which includes the processes of match homonymous elements between VGI and SDI vector data , change data detection, SDI spatial database update and new data product publication to end-users. Then, the proposed updating cycle is deeply discussed about the feasibility of which can detect the changed elements in time and shorten the update period, provide more accurate geometry and attribute data for spatial data infrastructure and support update propagation.

  13. Updating in Models of Spatial Memory

    NASA Astrophysics Data System (ADS)

    Rump, Björn; McNamara, Timothy P.

    This chapter discusses a new model of spatial memory and updating. The model includes an egocentric subsystem that computes and represents transient self-to-object spatial relations and an environmental subsystem that forms enduring representations of environments using intrinsic reference systems. Updating occurs in both subsystems, but only the egocentric subsystem readily provides object locations relative to any adopted orientation. In the absence of visual support, updating in the egocentric subsystem is limited, and object locations may have to be retrieved from the orientation dependent environmental subsystem. The model is evaluated in light of the results of numerous studies from the areas of spatial memory and spatial updating and contrasted with two alternative models. Furthermore, results are presented that suggest that interobject spatial relations are preferentially represented when they are aligned with intrinsic reference directions in the environmental subsystem.

  14. Updating Geospatial Data from Large Scale Data Sources

    NASA Astrophysics Data System (ADS)

    Zhao, R.; Chen, J.; Wang, D.; Shang, Y.; Wang, Z.; Li, X.; Ai, T.

    2011-08-01

    In the past decades, many geospatial databases have been established at national, regional and municipal levels over the world. Nowadays, it has been widely recognized that how to update these established geo-spatial database and keep them up to date is most critical for the value of geo-spatial database. So, more and more efforts have been devoted to the continuous updating of these geospatial databases. Currently, there exist two main types of methods for Geo-spatial database updating: directly updating with remote sensing images or field surveying materials, and indirectly updating with other updated data result such as larger scale newly updated data. The former method is the basis because the update data sources in the two methods finally root from field surveying and remote sensing. The later method is often more economical and faster than the former. Therefore, after the larger scale database is updated, the smaller scale database should be updated correspondingly in order to keep the consistency of multi-scale geo-spatial database. In this situation, it is very reasonable to apply map generalization technology into the process of geo-spatial database updating. The latter is recognized as one of most promising methods of geo-spatial database updating, especially in collaborative updating environment in terms of map scale, i.e , different scale database are produced and maintained separately by different level organizations such as in China. This paper is focused on applying digital map generalization into the updating of geo-spatial database from large scale in the collaborative updating environment for SDI. The requirements of the application of map generalization into spatial database updating are analyzed firstly. A brief review on geospatial data updating based digital map generalization is then given. Based on the requirements analysis and review, we analyze the key factors for implementing updating geospatial data from large scale including technical

  15. Legislative Update, December 2009. Report 09-26

    ERIC Educational Resources Information Center

    Blair, Julia

    2009-01-01

    This update contains analyses of legislative initiatives being tracked by the staff of the California Postsecondary Education Commission (CPEC). At its December 15 meeting, CPEC staff provided an update on the priority higher education legislation, including recent amendments. A matrix of bills monitored by CPEC staff is included. Contents…

  16. ISS Update: Suitport Testing

    NASA Video Gallery

    ISS Update commentator Lynnette Madison interviews Joel Maganza, Test Director, about thermal vacuum chambers and unmanned and human-testing with the Suitport. Questions? Ask us on Twitter @NASA_Jo...

  17. Respiratory Conditions Update: Asthma.

    PubMed

    Zeller, Timothy A

    2016-09-01

    Asthma is a chronic respiratory disease characterized by chronic airway inflammation and variable expiratory airflow limitation. Related clinical features include wheezing, dyspnea, chest tightness, and cough that worsens at night or in the early morning, and that varies over time and in intensity. A finding of variable expiratory airflow limitation on spirometry confirms the diagnosis. A forced expiratory volume in 1 second to forced vital capacity ratio less than the level predicted for the patient's age is suggestive of airflow limitation. Variability also must be confirmed. Updated guidelines recommend control-based management administered in a stepwise manner, with goals of achieving symptom control and minimizing the risks of exacerbations, future fixed airway limitation, and adverse effects of therapy. There is good evidence for the effectiveness of asthma education and self-management plans. Short-acting bronchodilators should be used as needed for symptom relief, with the addition of an inhaled corticosteroid early as maintenance therapy if symptoms are not well controlled. If asthma remains uncontrolled despite therapy, patients should be referred for more specialized treatment. Biomarkers, biologic drugs, and endoscopic treatments are being studied in the management of severe asthma, and ongoing research may determine which patients might benefit most from these emerging therapies. PMID:27576231

  18. Update on Banned Substances 2013

    PubMed Central

    Barnes, Kenneth P.; Rainbow, Catherine R.

    2013-01-01

    Context: Doping has been pervasive throughout the history of athletic competitions and has only recently been regulated by organizations such as the World Anti-Doping Agency (WADA), US Anti-Doping Agency (USADA), and the National Collegiate Athletic Association (NCAA). These regulatory bodies were created to preserve fair play and maintain the safety of the participants. Their updated 2013 lists of banned substances and practices include a variety of drugs and practices that could cause harm to an athlete or give one an unfair competitive advantage. Evidence Acquisition: Published websites for the WADA, USADA, and NCAA were investigated. These governing bodies update and publish their lists annually. Results: The WADA, USADA, and NCAA monitor anabolic steroids, hormones, growth factors, β-agonists, hormone and metabolic modulators, masking agents, street drugs, manipulation of blood and blood components, chemical and physical manipulation, gene doping, stimulants, narcotics, glucocorticosteroids, and β-blockers. Some substances may be used by athletes but require formal exemption. The WADA has also recently created a category of nonapproved substances that have yet to be identified to curb athletes from experimenting with new doping agents. Conclusion: The lists of banned substances and practices per the WADA, USADA, and NCAA are in place to ensure the integrity of sports and maintain safe competition. Health care providers who work with athletes under the jurisdiction of these organizations should review updated lists of banned substances when prescribing medications. PMID:24427415

  19. Update of Thyroid Developmental Genes.

    PubMed

    Stoupa, Athanasia; Kariyawasam, Dulanjalee; Carré, Aurore; Polak, Michel

    2016-06-01

    Thyroid dysgenesis (TD) is the most common cause of congenital hypothyroidism in iodine-sufficient regions and includes a spectrum of developmental anomalies. The genetic components of TD are complex. Although a sporadic disease, advances in developmental biology have revealed monogenetic forms of TD. Inheritance is not based on a simple Mendelian pattern and additional genetic elements might contribute to the phenotypic spectrum. This article summarizes the key steps of normal thyroid development and provides an update on responsible genes and underlying mechanisms of TD. Up-to-date technologies in genetics and biology will allow us to advance in our knowledge of TD. PMID:27241962

  20. QDENSITY/QCWAVE: A Mathematica quantum computer simulation update

    NASA Astrophysics Data System (ADS)

    Tabakin, Frank

    2016-04-01

    The Mathematica quantum computer simulation packages QDENSITY and QCWAVE are updated for Mathematica 9-10.3. An overview is given of the new QDensity, QCWave, BTSystem and Circuits packages, which includes: (1) improved treatment of tensor products of states and density matrices, (2) major extension to include qutrit (triplet), as well as qubit (binary) and hybrid qubit/qutrit systems in the associated BTSystem package, (3) updated sample quantum computation algorithms, (4) entanglement studies, including Schmidt decomposition, entropy, mutual information, partial transposition, and calculation of the quantum discord. Examples of Bell's theorem and concurrence are also included. This update will hopefully aid in studies of QC dynamics.

  1. 10 CFR 72.70 - Safety analysis report updating.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Safety analysis report updating. 72.70 Section 72.70..., Reports, Inspections, and Enforcement § 72.70 Safety analysis report updating. (a) Each specific licensee..., the final safety analysis report (FSAR) to assure that the information included in the report...

  2. 10 CFR 72.248 - Safety analysis report updating.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Safety analysis report updating. 72.248 Section 72.248... Approval of Spent Fuel Storage Casks § 72.248 Safety analysis report updating. (a) Each certificate holder... section, the final safety analysis report (FSAR) to assure that the information included in the...

  3. Business/Industry/Education Linkages. A Bibliography Update.

    ERIC Educational Resources Information Center

    Florida State Univ., Tallahassee. Center for Instructional Development and Services.

    This is the second update to the bibliography focusing on the linkages of business, industry, and education originally published in May 1987. Citations in this update focus on secondary and postsecondary level linkages. Many citations have a vocational education component. Citations include administrative material, journal articles, opinion…

  4. Environmental Regulatory Update Table, January/February 1995

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Mayer, S.J.; Salk, M.S.

    1995-03-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives impacting environmental, health, and safety management responsibilities. the table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  5. Semileptonic meson decays in the quark model: An update

    SciTech Connect

    D. Scora; N. Isgur

    1995-03-01

    The authors present the predictions of ISGW2, an update of the ISGW quark model for semileptonic meson decays. The updated model incorporates a number of features which should make it more reliable, including the constraints imposed by Heavy Quark Symmetry, hyperfine distortions of wave-functions, and form factors with more realistic high recoil behaviors.

  6. Census in Schools Educator Update, July/August 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter includes the following items: (1) Census in Schools and…

  7. Incontinentia pigmenti diagnostic criteria update.

    PubMed

    Minić, S; Trpinac, D; Obradović, M

    2014-06-01

    In 1993 diagnostic criteria for incontinentia pigmenti (IP), a genodermatosis in which skin changes are usually combined with anomalies of other organs, were established. Approximately a decade ago, IKBKG gene mutation was discovered as a cause for IP. This finding has not been included in IP diagnosis so far. In addition, literature data pointed out a few other clinical findings as possible IP diagnostic criteria. Literature facts concerning IP diagnosis were analyzed. Different organ anomalies, their frequency and severity, were analyzed in the context of applicability as IP diagnostic criteria. Taking into account analyzed data from the literature, the proposal of updated IP diagnostic criteria was presented. We propose as major criteria one of the stages of IP skin lesions. As updated IP minor criteria in our proposal we included: dental, ocular; central nervous system (CNS), hair, nail, palate, breast and nipple anomalies; multiple male miscarriages, and IP pathohistological findings. In the diagnosis of IP, the presence of IKBKG mutation typical for IP, and existence of family relatives with diagnosed IP are taken into account. PMID:23802866

  8. Veterinary medicines update.

    PubMed

    2016-03-01

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:26940413

  9. Veterinary medicines update.

    PubMed

    2016-02-01

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:26851100

  10. Veterinary medicines update.

    PubMed

    2016-07-01

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:27365238

  11. Veterinary medicines update.

    PubMed

    2016-06-11

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:27288166

  12. Updating: Learning versus Supposing

    ERIC Educational Resources Information Center

    Zhao, Jiaying; Crupi, Vincenzo; Tentori, Katya; Fitelson, Branden; Osherson, Daniel

    2012-01-01

    Bayesian orthodoxy posits a tight relationship between conditional probability and updating. Namely, the probability of an event "A" after learning "B" should equal the conditional probability of "A" given "B" prior to learning "B". We examine whether ordinary judgment conforms to the orthodox view. In three experiments we found substantial…

  13. Supreme Court Update

    ERIC Educational Resources Information Center

    Taylor, Kelley R.

    2009-01-01

    "Chief Justice Flubs Oath." "Justice Ginsburg Has Cancer Surgery." At the start of this year, those were the news headlines about the U.S. Supreme Court. But January 2009 also brought news about key education cases--one resolved and two others on the docket--of which school administrators should take particular note. The Supreme Court updates on…

  14. Southern Horticultural Lab Update

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This publication is a new quarterly update for members of the Mississippi Nursery and Landscape Association that is published quarterly in their association newsletter. Two other versions of this newsletter are being submitted to the Louisiana Nursery and Landscape Association (LALNLA) and the Alaba...

  15. Veterinary medicines update.

    PubMed

    2016-09-10

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:27609956

  16. Veterinary medicines update.

    PubMed

    2016-08-01

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:27493045

  17. Energy 101: Wind Turbines - 2014 Update

    ScienceCinema

    None

    2014-06-05

    See how wind turbines generate clean electricity from the power of wind. The video highlights the basic principles at work in wind turbines, and illustrates how the various components work to capture and convert wind energy to electricity. This updated version also includes information on the Energy Department's efforts to advance offshore wind power. Offshore wind energy footage courtesy of Vestas.

  18. Young Children in Poverty: A Statistical Update.

    ERIC Educational Resources Information Center

    Li, Jiali; Bennett, Neil

    The highlights of this statistical update include a new profile of the extremely poor, poor, and near poor population of young children; the use of an alternative measure of young child poverty that provides new insights into the impact of programs and policies on the economic well-being of young children; and a brief examination of why the…

  19. Energy 101: Wind Turbines - 2014 Update

    SciTech Connect

    2014-05-06

    See how wind turbines generate clean electricity from the power of wind. The video highlights the basic principles at work in wind turbines, and illustrates how the various components work to capture and convert wind energy to electricity. This updated version also includes information on the Energy Department's efforts to advance offshore wind power. Offshore wind energy footage courtesy of Vestas.

  20. Internet Basics: Update 1996. ERIC Digest.

    ERIC Educational Resources Information Center

    Tennant, Roy

    This update to a previous digest briefly describes the Internet computer network, the physical connections and communication protocols that make it possible, and the applications and information resources the network provides. The applications covered include electronic mail and listservs, the world wide web, telnet connections with remote library…

  1. New Drugs Prompt Myeloma Guidelines Update.

    PubMed

    2016-07-01

    Updates to the National Comprehensive Cancer Network's guidelines for treating multiple myeloma include new criteria for initiating treatment and an expanded menu of therapies based on recent FDA approvals. The changes extend the population of patients eligible for treatment and provide oncologists with better prognostic tools. PMID:27207892

  2. Social Studies Program: [Grade] 3. Updated Version.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Bureau of Curriculum Development.

    This updated New York social studies curriculum guide for third grade has 10 key concepts that include change, citizenship, culture, empathy, environment, identity, interdependence, nation-state, scarcity, and technology. These concepts are taught in 23 lessons through social, political, economic, geographic, and historic perspectives. Each lesson…

  3. Apollo Lunar Sample Photograph Digitization Project Update

    NASA Technical Reports Server (NTRS)

    Todd, N. S.; Lofgren, G. E.

    2012-01-01

    This is an update of the progress of a 4-year data restoration project effort funded by the LASER program to digitize photographs of the Apollo lunar rock samples and create high resolution digital images and undertaken by the Astromaterials Acquisition and Curation Office at JSC [1]. The project is currently in its last year of funding. We also provide an update on the derived products that make use of the digitized photos including the Lunar Sample Catalog and Photo Database[2], Apollo Sample data files for GoogleMoon[3].

  4. State energy-price system: 1981 update

    SciTech Connect

    Fang, J.M.; Imhoff, K.L.; Hood, L.J.

    1983-08-01

    This report updates the State Energy Price Data System (STEPS) to include state-level energy prices by fuel and by end-use sectors for 1981. Both physical unit prices and Btu prices are presented. Basic documentation of the data base remains generally the same as in the original report: State Energy Price System; Volume 1: Overview and Technical Documentation (DOE/NBB-0029 Volume 1 of 2, November 1982). The present report documents only the changes in procedures necessitated by the update to 1981 and the corrections to the basic documentation.

  5. Colposcopy: an evidence-based update.

    PubMed

    Dresang, Lee T

    2005-01-01

    Colposcopy is a diagnostic procedure, most commonly used in the diagnosis of cervical intraepithelial neoplasia and lower genital tract carcinoma. In this article, evidence-based management strategies are updated with discussion of the 2001 American Society for Colposcopy and Cervical Pathology Consensus Guidelines. Practice management issues include methods to improve cervical cancer screening rates, coding and billing, and telemedicine. Textbooks, CD-ROMs, and courses are listed for new learners and experienced providers who want to update and sharpen their skills. PMID:16148248

  6. Pump apparatus including deconsolidator

    DOEpatents

    Sonwane, Chandrashekhar; Saunders, Timothy; Fitzsimmons, Mark Andrew

    2014-10-07

    A pump apparatus includes a particulate pump that defines a passage that extends from an inlet to an outlet. A duct is in flow communication with the outlet. The duct includes a deconsolidator configured to fragment particle agglomerates received from the passage.

  7. Formulation of consumables management models: Consumables flight planning worksheet update. [space shuttles

    NASA Technical Reports Server (NTRS)

    Newman, C. M.

    1977-01-01

    The updated consumables flight planning worksheet (CFPWS) is documented. The update includes: (1) additional consumables: ECLSS ammonia, APU propellant, HYD water; (2) additional on orbit activity for development flight instrumentation (DFI); (3) updated use factors for all consumables; and (4) sources and derivations of the use factors.

  8. Optical modulator including grapene

    DOEpatents

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  9. Updating outdated predictive accident models.

    PubMed

    Wood, A G; Mountain, L J; Connors, R D; Maher, M J; Ropkins, K

    2013-06-01

    Reliable predictive accident models (PAMs) (also referred to as safety performance functions (SPFs)) are essential to design and maintain safe road networks however, ongoing changes in road and vehicle design coupled with road safety initiatives, mean that these models can quickly become dated. Unfortunately, because the fitting of sophisticated PAMs including a wide range of explanatory variables is not a trivial task, available models tend to be based on data collected many years ago and seem unlikely to give reliable estimates of current accidents. Large, expensive studies to produce new models are likely to be, at best, only a temporary solution. This paper thus seeks to develop a practical and efficient methodology to allow currently available PAMs to be updated to give unbiased estimates of accident frequencies at any point in time. Two principal issues are examined: the extent to which the temporal transferability of predictive accident models varies with model complexity; and the practicality and efficiency of two alternative updating strategies. The models used to illustrate these issues are the suites of models developed for rural dual and single carriageway roads in the UK. These are widely used in several software packages in spite of being based on data collected during the 1980s and early 1990s. It was found that increased model complexity by no means ensures better temporal transferability and that calibration of the models using a scale factor can be a practical alternative to fitting new models. PMID:23510788

  10. [Update on anticancer drugs].

    PubMed

    Roila, Fausto; Ballatori, Enzo

    2014-01-01

    Update on anticancer drugs. A thorough review of the clinical trials published over the last two years in major medical and oncological journals on a comprehensive spectrum of oncological conditions aims to provide at the same time (as the authors are well known representatives of the critical and complementary competences of clinical care and research methodology) an interesting double opportunity of update on: a) what is truly (i.e.documented and reliable) innovative and deserves adoption in daily care,vs what is either purely suggestive or clearly misleading; b) what are the methological, concrete, simple rules to observe in a field which is certainly moving fast, but at the same time generates highly controversial behaviors in research as well as in daily practices. The accompanying editorial (pag 60-63) further illustrates the way and the yield of using this material and approach both in the areas of nursing sciences and practice. PMID:25002061

  11. Sequence History Update Tool

    NASA Technical Reports Server (NTRS)

    Khanampompan, Teerapat; Gladden, Roy; Fisher, Forest; DelGuercio, Chris

    2008-01-01

    The Sequence History Update Tool performs Web-based sequence statistics archiving for Mars Reconnaissance Orbiter (MRO). Using a single UNIX command, the software takes advantage of sequencing conventions to automatically extract the needed statistics from multiple files. This information is then used to populate a PHP database, which is then seamlessly formatted into a dynamic Web page. This tool replaces a previous tedious and error-prone process of manually editing HTML code to construct a Web-based table. Because the tool manages all of the statistics gathering and file delivery to and from multiple data sources spread across multiple servers, there is also a considerable time and effort savings. With the use of The Sequence History Update Tool what previously took minutes is now done in less than 30 seconds, and now provides a more accurate archival record of the sequence commanding for MRO.

  12. How Documentalists Update SIMBAD

    NASA Astrophysics Data System (ADS)

    Buga, M.; Bot, C.; Brouty, M.; Bruneau, C.; Brunet, C.; Cambresy, L.; Eisele, A.; Genova, F.; Lesteven, S.; Loup, C.; Neuville, M.; Oberto, A.; Ochsenbein, F.; Perret, E.; Siebert, A.; Son, E.; Vannier, P.; Vollmer, B.; Vonflie, P.; Wenger, M.; Woelfel, F.

    2015-04-01

    The Strasbourg astronomical Data Center (CDS) was created in 1972 and has had a major role in astronomy for more than forty years. CDS develops a service called SIMBAD that provides basic data, cross-identifications, bibliography, and measurements for astronomical objects outside the solar system. It brings to the scientific community an added value to content which is updated daily by a team of documentalists working together in close collaboration with astronomers and IT specialists. We explain how the CDS staff updates SIMBAD with object citations in the main astronomical journals, as well as with astronomical data and measurements. We also explain how the identification is made between the objects found in the literature and those already existing in SIMBAD. We show the steps followed by the documentalist team to update the database using different tools developed at CDS, like the sky visualizer Aladin, and the large catalogues and survey database VizieR. As a direct result of this teamwork, SIMBAD integrates almost 10.000 bibliographic references per year. The service receives more than 400.000 queries per day.

  13. To Your Health: NLM update transcript - Zika research needs

    MedlinePlus

    ... transcript050216.html To Your Health: NLM update Transcript Zika research needs : 05/02/2016 To use the ... up on weekly topics. Research priorities for the Zika virus include a better understanding of how it ...

  14. EPA National Center for Computational Toxicology UPDATE (ICCVAM public forum)

    EPA Science Inventory

    A presentation to the ICCVAM Public Forum on several new and exciting activities at NCCT, including Chemical library update, Chemistry Dashboard, Retrofitting in vitro assays with metabolic competence and In vitro PK.

  15. National Solar Radiation Database 1991-2010 Update: User's Manual

    SciTech Connect

    Wilcox, S. M.

    2012-08-01

    This user's manual provides information on the updated 1991-2010 National Solar Radiation Database. Included are data format descriptions, data sources, production processes, and information about data uncertainty.

  16. Agent Communication for Dynamic Belief Update

    NASA Astrophysics Data System (ADS)

    Kobayashi, Mikito; Tojo, Satoshi

    Thus far, various formalizations of rational / logical agent model have been proposed. In this paper, we include the notion of communication channel and belief modality into update logic, and introduce Belief Update Logic (BUL). First, we discuss that how we can reformalize the inform action of FIPA-ACL into communication channel, which represents a connection between agents. Thus, our agents can send a message only when they believe, and also there actually is, a channel between him / her and a receiver. Then, we present a static belief logic (BL) and show its soundness and completeness. Next, we develop the logic to BUL, which can update Kripke model by the inform action; in which we show that in the updated model the belief operator also satisfies K45. Thereafter, we show that every sentence in BUL can be translated into BL; thus, we can contend that BUL is also sound and complete. Furthermore, we discuss the features of CUL, including the case of inconsistent information, as well as channel transmission. Finally, we summarize our contribution and discuss some future issues.

  17. Updates in diabetic peripheral neuropathy

    PubMed Central

    Juster-Switlyk, Kelsey; Smith, A. Gordon

    2016-01-01

    Diabetes has become one of the largest global health-care problems of the 21 st century. According to the Centers for Disease Control and Prevention, the population prevalence of diabetes in the US is approaching 10% and is increasing by 5% each year. Diabetic neuropathy is the most common complication associated with diabetes mellitus. Diabetes causes a broad spectrum of neuropathic complications, including acute and chronic forms affecting each level of the peripheral nerve, from the root to the distal axon. This review will focus on the most common form, distal symmetric diabetic polyneuropathy. There has been an evolution in our understanding of the pathophysiology and the management of diabetic polyneuropathy over the past decade. We highlight these new perspectives and provide updates from the past decade of research. PMID:27158461

  18. Acute Decompensated Heart Failure Update

    PubMed Central

    Teerlink, John R; Alburikan, Khalid; Metra, Marco; Rodgers, Jo E

    2015-01-01

    Acute decompensated heart failure (ADHF) continues to increase in prevalence and is associated with substantial mortality and morbidity including frequent hospitalizations. The American Heart Association is predicting that more than eight million Americans will have heart failure by 2030 and that the total direct costs associated with the disease will rise from $21 billion in 2012 to $70 billion in 2030. The increase in the prevalence and cost of HF is primarily the result of shifting demographics and a growing population. Although many large, randomized, controlled clinical trials have been conducted in patients with chronic heart failure, it was not until recently that a growing number of studies began to address the management of ADHF. It is the intent of this review to update the clinician regarding the evaluation and optimal management of ADHF. PMID:24251454

  19. The UCSC Genome Browser database: 2016 update.

    PubMed

    Speir, Matthew L; Zweig, Ann S; Rosenbloom, Kate R; Raney, Brian J; Paten, Benedict; Nejad, Parisa; Lee, Brian T; Learned, Katrina; Karolchik, Donna; Hinrichs, Angie S; Heitner, Steve; Harte, Rachel A; Haeussler, Maximilian; Guruvadoo, Luvina; Fujita, Pauline A; Eisenhart, Christopher; Diekhans, Mark; Clawson, Hiram; Casper, Jonathan; Barber, Galt P; Haussler, David; Kuhn, Robert M; Kent, W James

    2016-01-01

    For the past 15 years, the UCSC Genome Browser (http://genome.ucsc.edu/) has served the international research community by offering an integrated platform for viewing and analyzing information from a large database of genome assemblies and their associated annotations. The UCSC Genome Browser has been under continuous development since its inception with new data sets and software features added frequently. Some release highlights of this year include new and updated genome browsers for various assemblies, including bonobo and zebrafish; new gene annotation sets; improvements to track and assembly hub support; and a new interactive tool, the "Data Integrator", for intersecting data from multiple tracks. We have greatly expanded the data sets available on the most recent human assembly, hg38/GRCh38, to include updated gene prediction sets from GENCODE, more phenotype- and disease-associated variants from ClinVar and ClinGen, more genomic regulatory data, and a new multiple genome alignment. PMID:26590259

  20. The UCSC Genome Browser database: 2016 update

    PubMed Central

    Speir, Matthew L.; Zweig, Ann S.; Rosenbloom, Kate R.; Raney, Brian J.; Paten, Benedict; Nejad, Parisa; Lee, Brian T.; Learned, Katrina; Karolchik, Donna; Hinrichs, Angie S.; Heitner, Steve; Harte, Rachel A.; Haeussler, Maximilian; Guruvadoo, Luvina; Fujita, Pauline A.; Eisenhart, Christopher; Diekhans, Mark; Clawson, Hiram; Casper, Jonathan; Barber, Galt P.; Haussler, David; Kuhn, Robert M.; Kent, W. James

    2016-01-01

    For the past 15 years, the UCSC Genome Browser (http://genome.ucsc.edu/) has served the international research community by offering an integrated platform for viewing and analyzing information from a large database of genome assemblies and their associated annotations. The UCSC Genome Browser has been under continuous development since its inception with new data sets and software features added frequently. Some release highlights of this year include new and updated genome browsers for various assemblies, including bonobo and zebrafish; new gene annotation sets; improvements to track and assembly hub support; and a new interactive tool, the “Data Integrator”, for intersecting data from multiple tracks. We have greatly expanded the data sets available on the most recent human assembly, hg38/GRCh38, to include updated gene prediction sets from GENCODE, more phenotype- and disease-associated variants from ClinVar and ClinGen, more genomic regulatory data, and a new multiple genome alignment. PMID:26590259

  1. Fuel Cell Handbook update

    SciTech Connect

    Owens, W.R.; Hirschenhofer, J.H.; Engleman, R.R. Jr.; Stauffer, D.B.

    1993-11-01

    The objective of this work was to update the 1988 version of DOE`s Fuel Cell Handbook. Significant developments in the various fuel cell technologies required revisions to reflect state-of-the-art configurations and performance. The theoretical presentation was refined in order to make the handbook more useful to both the casual reader and fuel cell or systems analyst. In order to further emphasize the practical application of fuel cell technologies, the system integration information was expanded. In addition, practical elements, such as suggestions and guidelines to approximate fuel cell performance, were provided.

  2. Fuel Cell Handbook update

    NASA Astrophysics Data System (ADS)

    Owens, W. R.; Hirschenhofer, J. H.; Engleman, R. R., Jr.; Stauffer, D. B.

    The objective of this work was to update the 1988 version of DOE's Fuel Cell Handbook. Significant developments in the various fuel cell technologies required revisions to reflect state-of-the-art configurations and performance. The theoretical presentation was refined in order to make the handbook more useful to both the casual reader and fuel cell or systems analyst. In order to further emphasize the practical application of fuel cell technologies, the system integration information was expanded. In addition, practical elements, such as suggestions and guidelines to approximate fuel cell performance, were provided.

  3. Delta Coherence Protocols: The Home Update Protocol

    SciTech Connect

    Williams, C.; Reynolds, P.F.; de Supinoki, B.

    2000-07-21

    We describe a new class of directory coherence protocols called delta coherence protocols that use network guarantees to support a new and highly concurrent approach to maintain a consistent shared memory. Delta coherence protocols are more concurrent than other coherence protocols in that they allow processes to pipeline memory accesses without violating sequential consistency; support multiple concurrent readers and writers to the same cache block; and allow processes to access multiple shared variables atomically without invalidating the copies held by other processes or otherwise obtaining exclusive access to the referenced variables. Delta protocols include both update and invalidate protocols. In this paper we describe the simplest, most basic delta protocol, an update protocol called the home update protocol. Delta protocols are based on isotach network guarantees. An isotach network maintains a logical time system that allows each process to predict and control the logical time at which its messages are received. Processes use isotach guarantees to control the logical time at which their requests on shared memory appear to be executed. We prove the home update protocol is correct using logical time to reason about the order in which requests are executed.

  4. STS-51-L Debris Aboard the USGS Cutter Dallas

    NASA Technical Reports Server (NTRS)

    1986-01-01

    On January 28, 1986, the Space Shuttle Challenger and her seven-member crew were lost when a ruptured O-ring in the right Solid Rocket Booster caused an explosion soon after launch. With the help of the U.S. Coast Guard and the U.S. Navy, search and recovery teams began retrieving pieces of the Shuttle from the Atlantic Ocean soon after the accident. Vessels brought the debris to the Trident Basin at Cape Canaveral Air Force Station, where they waited to be shipped to Kennedy Space Center for investigation. The USCG Cutter Dallas transported this fragment of exterior tiling.

  5. STS-51-L Recovered Debris (ET and SRBs)

    NASA Technical Reports Server (NTRS)

    1986-01-01

    On January 28, 1986, the Space Shuttle Challenger and her seven-member crew were lost when a ruptured O-ring in the right Solid Rocket Booster caused an explosion soon after launch. After the accident, search and recovery teams worked for months to bring debris from the Shuttle to impoundment areas at the Kennedy Space Center and the Cape Canaveral Air Force Station, where reconstruction teams separated the pieces of the Orbiter from those of the External Tank (ET) and the Solid Rocket Boosters (SRB). Taped squares on the floor turned the impoundment areas into a grid in which the reconstruction teams could piece together the Shuttle debris like a puzzle with many missing segments. Shown here are the remains of the ET and, at the far end, the frustums of the two SRBs. The frustum is the section of the conical end of the rocket that remains after the tip has been removed.

  6. Effect of display update interval, update type, and background on perception of aircraft separation on a cockpit display on traffic information

    NASA Technical Reports Server (NTRS)

    Jago, S.; Baty, D.; Oconnor, S.; Palmer, E.

    1981-01-01

    The concept of a cockpit display of traffic information (CDTI) includes the integration of air traffic, navigation, and other pertinent information in a single electronic display in the cockpit. Concise display symbology was developed for use in later full-mission simulator evaluations of the CDTI concept. Experimental variables used included the update interval motion of the aircraft, the update type, (that is, whether the two aircraft were updated at the same update interval or not), the background (grid pattern or no background), and encounter type (straight or curved). Only the type of encounter affected performance.

  7. Working Memory Updating Latency Reflects the Cost of Switching between Maintenance and Updating Modes of Operation

    ERIC Educational Resources Information Center

    Kessler, Yoav; Oberauer, Klaus

    2014-01-01

    Updating and maintenance of information are 2 conflicting demands on working memory (WM). We examined the time required to update WM (updating latency) as a function of the sequence of updated and not-updated items within a list. Participants held a list of items in WM and updated a variable subset of them in each trial. Four experiments that vary…

  8. Update of axion CDM energy density

    SciTech Connect

    Huh, Ji-Haeng

    2008-11-23

    We update cosmological bound on axion model. The contribution from the anharmonic effect and the newly introduced initial overshoot correction are considered. We present an explicit formula for the axion relic density in terms of the QCD scale {lambda}{sub QCD}, the current quark masses m{sub q}'s and the Peccei-Quinn scale F{sub a}, including firstly introduced 1.85 factor which is from the initial overshoot.

  9. Memory Updating and Mental Arithmetic

    PubMed Central

    Han, Cheng-Ching; Yang, Tsung-Han; Lin, Chia-Yuan; Yen, Nai-Shing

    2016-01-01

    Is domain-general memory updating ability predictive of calculation skills or are such skills better predicted by the capacity for updating specifically numerical information? Here, we used multidigit mental multiplication (MMM) as a measure for calculating skill as this operation requires the accurate maintenance and updating of information in addition to skills needed for arithmetic more generally. In Experiment 1, we found that only individual differences with regard to a task updating numerical information following addition (MUcalc) could predict the performance of MMM, perhaps owing to common elements between the task and MMM. In Experiment 2, new updating tasks were designed to clarify this: a spatial updating task with no numbers, a numerical task with no calculation, and a word task. The results showed that both MUcalc and the spatial task were able to predict the performance of MMM but only with the more difficult problems, while other updating tasks did not predict performance. It is concluded that relevant processes involved in updating the contents of working memory support mental arithmetic in adults. PMID:26869971

  10. Updates Technologies of Media Change

    ERIC Educational Resources Information Center

    Comer, Joshua

    2015-01-01

    Whether as status notifications in news feeds or interactive prompts in online video services, updates punctuate the background routines of media by bringing a variety of changes to the attention of users. In this dissertation I argue that updates rationalize media change by making previously obscure actions of users and movements of technologies…

  11. ASDSO updates bibliography, creates support database

    SciTech Connect

    Spragens, L. )

    1993-04-01

    The Association of State Dam Safety Officials has updated its Bibliography of Dam Safety Practices, originally published in 1990 with assistance from the US Committee on Large Dams. The new document lists publications addressing dam safety issues and includes 20 subject headings. The Federal Emergency Management Agency underwrote the update, which includes information about journal articles on dam safety, conference presentations, and new books and manuals. The publication also contains information about obtaining copies of the documents. The bibliography features a new section on use of geosynthetics in dam safety, compiled by Greg Hammer, of ASDSO's Technical Committee. Dam break analysis, emergency action planning, instrumentation, inspections, overtopping of dams, rehabilitation of dams, risk analysis, and seismic behavior are also included. In conjunction with the release of the updated bibliography, ASDSO is creating a computer database for its members that contains information from the bibliography. ASDSO also is in the process of adding information to the database about current research in dam safety. When the database becomes available later this year, members will be able to search for information on research in a specific subject area. Users also will be able to search for research groups, individuals, and universities to obtain an overview of who is conducting research in dam safety. Additionally, the database will allow the user to search for subject matter experts when looking for conference speakers and writers with specific specialties.

  12. Environmental Regulatory Update Table, November--December 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1994-01-01

    The Environmental Regulatory Update Table provides information on regulatory of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  13. Environmental Regulatory Update Table, March/April 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1992-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  14. Environmental Regulatory Update Table, July--August 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Lewis, E.B.; Salk, M.S.

    1992-09-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  15. Environmental regulatory update table, September--October 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Lewis, E.B.; Salk, M.S.

    1992-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  16. Environmental Regulatory Update Table, November--December 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Lewis, E.B.; Salk, M.S.

    1993-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly wit information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  17. Environmental Regulatory Update Table, January--February 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-03-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  18. Environmental regulatory update table: September/October 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Salk, M.S.

    1994-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  19. Environmental sciences division: Environmental regulatory update table July 1988

    SciTech Connect

    Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1988-08-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  20. Environmental Regulatory Update Table, March/April 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bimonthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  1. Environmental Regulatory Update Table, March/April 1993. Revision 1

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bimonthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  2. Environmental Regulatory Update Table, January/February 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1992-03-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action. This table is for January/February 1992.

  3. Environmental Regulatory Update Table, January--February 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1994-03-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations ad contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  4. Environmental regulatory update table, March--April 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Salk, M.S.

    1994-03-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  5. Environmental Regulatory Update Table, May--June 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Salk, M.S.

    1994-07-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bimonthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  6. Environmental Regulatory Update Table, September/October 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operation and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  7. Environmental regulatory update table November--December 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Mayer, S.J.; Salk, M.S.

    1995-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  8. Environmental regulatory update table, July/August 1994

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Bock, R.E.; Salk, M.S.

    1994-09-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  9. Environmental Regulatory Update Table, May/June 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-07-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bimonthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  10. Environmental Regulatory Update Table July/August 1993

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.; Danford, G.S.; Lewis, E.B.

    1993-09-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated bi-monthly with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  11. Update on toxic myopathies.

    PubMed

    Mastaglia, F L; Needham, M

    2012-02-01

    The toxic myopathies are a clinically and pathologically diverse group of disorders that can be caused by a variety of therapeutic agents used in clinical practice, as well as various venoms and other biological toxins. The most important iatrogenic causes are the statin and fibrate cholesterol-lowering agents that can cause a severe necrotizing myopathy and acute rhabdomyolysis and myoglobinuria. The current update focuses on the mechanisms of statin myotoxicity and the importance of genetic predisposing factors for statin myopathy, as well as the recently described form of necrotizing autoimmune myopathy, which is associated with antibodies to the 3-hydroxy-3-methylglutaryl-coenzyme A reductase enzyme and is responsive to aggressive immunotherapy. Mitochondrial myopathies associated with antiretroviral agents and the pyrimidine nucleoside analogue clevudine, and recent reports of myopathies caused by ingestion of red yeast rice and toxic species of mushrooms are also discussed. PMID:21968786

  12. Homeodomain proteins: an update.

    PubMed

    Bürglin, Thomas R; Affolter, Markus

    2016-06-01

    Here, we provide an update of our review on homeobox genes that we wrote together with Walter Gehring in 1994. Since then, comprehensive surveys of homeobox genes have become possible due to genome sequencing projects. Using the 103 Drosophila homeobox genes as example, we present an updated classification. In animals, there are 16 major classes, ANTP, PRD, PRD-LIKE, POU, HNF, CUT (with four subclasses: ONECUT, CUX, SATB, and CMP), LIM, ZF, CERS, PROS, SIX/SO, plus the TALE superclass with the classes IRO, MKX, TGIF, PBC, and MEIS. In plants, there are 11 major classes, i.e., HD-ZIP (with four subclasses: I to IV), WOX, NDX, PHD, PLINC, LD, DDT, SAWADEE, PINTOX, and the two TALE classes KNOX and BEL. Most of these classes encode additional domains apart from the homeodomain. Numerous insights have been obtained in the last two decades into how homeodomain proteins bind to DNA and increase their specificity by interacting with other proteins to regulate cell- and tissue-specific gene expression. Not only protein-DNA base pair contacts are important for proper target selection; recent experiments also reveal that the shape of the DNA plays a role in specificity. Using selected examples, we highlight different mechanisms of homeodomain protein-DNA interaction. The PRD class of homeobox genes was of special interest to Walter Gehring in the last two decades. The PRD class comprises six families in Bilateria, and tinkers with four different motifs, i.e., the PAIRED domain, the Groucho-interacting motif EH1 (aka Octapeptide or TN), the homeodomain, and the OAR motif. Homologs of the co-repressor protein Groucho are also present in plants (TOPLESS), where they have been shown to interact with small amphipathic motives (EAR), and in yeast (TUP1), where we find an EH1-like motif in MATα2. PMID:26464018

  13. ADAS Update and Maintainability

    NASA Technical Reports Server (NTRS)

    Watson, Leela R.

    2010-01-01

    Since 2000, both the National Weather Service Melbourne (NWS MLB) and the Spaceflight Meteorology Group (SMG) have used a local data integration system (LOIS) as part of their forecast and warning operations. The original LOIS was developed by the Applied Meteorology Unit (AMU) in 1998 (Manobianco and Case 1998) and has undergone subsequent improvements. Each has benefited from three-dimensional (3-D) analyses that are delivered to forecasters every 15 minutes across the peninsula of Florida. The intent is to generate products that enhance short-range weather forecasts issued in support of NWS MLB and SMG operational requirements within East Central Florida. The current LDIS uses the Advanced Regional Prediction System (ARPS) Data Analysis System (AD AS) package as its core, which integrates a wide variety of national, regional, and local observational data sets. It assimilates all available real-time data within its domain and is run at a finer spatial and temporal resolution than current national or regional-scale analysis packages. As such, it provides local forecasters with a more comprehensive understanding of evolving fine-scale weather features. Over the years, the LDIS has become problematic to maintain since it depends on AMU-developed shell scripts that were written for an earlier version of the ADAS software. The goals of this task were to update the NWS MLB/SMG LDIS with the latest version of ADAS, incorporate new sources of observational data, and upgrade and modify the AMU-developed shell scripts written to govern the system. In addition, the previously developed ADAS graphical user interface (GUI) was updated. Operationally, these upgrades will result in more accurate depictions of the current local environment to help with short-range weather forecasting applications, while also offering an improved initialization for local versions of the Weather Research and Forecasting (WRF) model used by both groups.

  14. Atomic spectrometry update - atomic mass spectrometry.

    SciTech Connect

    Bacon, J.; Crain, J. S.; McMahon, A. W.; Williams, J. G.; Analytical Chemistry Laboratory; The Macaulay Land Use Research Inst.; Manchester Metropolitan Univ.; Imperial Coll.

    1996-10-01

    The MS and XRF updates have been published together since their introduction in 1988. In the last few years, however, the two sections have been prepared independently of each other and it therefore seemed appropriate to publish the two sections separately. With effect from this issue, the MS Update will appear in the October issue of JAAS and the XRF Update in the November issue. The format used for the MS section is broadly similar to that used last year, with some additional sub-headings. This Update is intended to cover all atomic and stable isotopic MS techniques, but not those used in studies of fundamental nuclear physics and exotic nuclei far from stability. Also excluded are those reports in which MS is used as a tool in the study of molecular processes and of gaseous components. the review is based on critical selection of developments in instrumentation and methodology, notable for their innovation, originality or achievement of significant advances, and is not intended to be comprehensive in its coverage. Conference papers are only included if they contain enough information to show they meet these criteria, and our policy in general remains one of waiting for a development to appear in a full paper before inclusion in the review. a similar policy applies to foreign language papers unlikely to reach a wide audience. Routine applications of atomic MS are not included in this Update and the reader is referred to the Updates on Industrial Analysis: Metals, Chemicals and Advanced Materials (96/416), Environmental Analysis (96/1444) and Clinical and Biological Materials, Food and Beverages (96/2479). Also excluded are those applications, even if not routine, which use atomic spectroscopy as a tool for the study of a non-atomic property, for example, the use of stable isotope labeling of carbon or nitrogen in biomolecules in metabolic studies. There have been few general reviews on atomic MS of note in the period covered by this update. That of Colodner et al

  15. Cardiovascular Update: Risk, Guidelines, and Recommendations.

    PubMed

    Pearson, Tamera

    2015-09-01

    This article provides an update of the current status of cardiovascular disease (CVD) in the United States, including a brief review of the underlying pathophysiology and epidemiology. This article presents a discussion of the latest American Heart Association guidelines that introduce the concept of promoting ideal cardiovascular health, defined by seven identified metrics. Specific CVD risk factors and utilization of the 10-year CVD event prediction calculator are discussed. In addition, current management recommendations of health-related conditions that increase risk for CVD, such as hypertension and hypercholesterolemia, are provided. Finally, a discussion of detailed evidence-based lifestyle recommendations to promote cardiovascular health and reduce CVD risks concludes the update. PMID:26156147

  16. A New Dynamic Accumulator for Batch Updates

    NASA Astrophysics Data System (ADS)

    Wang, Peishun; Wang, Huaxiong; Pieprzyk, Josef

    A dynamic accumulator is an algorithm, which gathers together a large set of elements into a constant-size value such that for a given element accumulated, there is a witness confirming that the element was indeed included into the value, with a property that accumulated elements can be dynamically added and deleted into/from the original set such that the cost of an addition or deletion operation is independent of the number of accumulated elements. Although the first accumulator was presented ten years ago, there is still no standard formal definition of accumulators. In this paper, we generalize formal definitions for accumulators, formulate a security game for dynamic accumulators so-called Chosen Element Attack (CEA), and propose a new dynamic accumulator for batch updates based on the Paillier cryptosystem. Our construction makes a batch of update operations at unit cost. We prove its security under the extended strong RSA (es-RSA) assumption.

  17. State Energy Price System: 1982 update

    SciTech Connect

    Imhoff, K.L.; Fang, J.M.

    1984-10-01

    The State Energy Price System (STEPS) contains estimates of energy prices for ten major fuels (electricity, natural gas, metallurgical coal, steam coal, distillate, motor gasoline, diesel, kerosene/jet fuel, residual fuel, and liquefied petroleum gas), by major end-use sectors (residential, commercial, industrial, transportation, and electric utility), and by state through 1982. Both physical unit prices and prices per million Btu are included in STEPS. Major changes in STEPS data base for 1981 and 1982 are described. The most significant changes in procedures for the updates occur in the residential sector distillate series and the residential sector kerosene series. All physical unit and Btu prices are shown with three significant digits instead of with four significant digits as shown in the original documentation. Details of these and other changes are contained in this report, along with the updated data files. 31 references, 65 tables.

  18. Update on percutaneous mitral commissurotomy.

    PubMed

    Nunes, Maria Carmo P; Nascimento, Bruno Ramos; Lodi-Junqueira, Lucas; Tan, Timothy C; Athayde, Guilherme Rafael Sant'Anna; Hung, Judy

    2016-04-01

    Percutaneous mitral commissurotomy (PMC) is the first-line therapy for managing rheumatic mitral stenosis. Over the past two decades, the indications of the procedure have expanded to include patients with unfavourable valve anatomy as a consequence of epidemiological changes in patient population. The procedure is increasingly being performed in patients with increased age, more deformed valves and associated comorbidities. Echocardiography plays a crucial role in patient selection and to guide a more efficient procedure. The main echocardiographic predictors of immediate results after PMC are mitral valve area, subvalvular thickening and valve calcification, especially at the commissural level. However, procedural success rate is not only dependent on valve anatomy, but a number of other factors including patient characteristics, interventional management strategies and operator expertise. Severe mitral regurgitation continues to be the most common immediate procedural complication with unchanged incidence rates over time. The long-term outcome after PMC is mainly determined by the immediate procedural results. Postprocedural parameters associated with late adverse events include mitral valve area, mitral regurgitation severity, mean gradient and pulmonary artery pressure. Mitral restenosis is an important predictor of event-free survival rates after successful PMC, and repeat procedure can be considered in cases with commissural refusion. PMC can be performed in special situations, which include high-risk patients, during pregnancy and in the presence of left atrial thrombus, especially in centres with specialised expertise. Therefore, procedural decision-making should take into account the several determinant factors of PMC outcomes. This paper provides an overview and update of PMC techniques, complications, immediate and long-term results over time, and assessment of suitability for the procedure. PMID:26743926

  19. ISS Update: SpaceX Dragon Launch Update

    NASA Video Gallery

    NASA Public Affairs Office commentator Pat Ryan talks with Mike Horkachuck, NASA Project Executive for SpaceX, for an update on the SpaceX Dragon's next launch attempt scheduled for Tuesday at 3:44...

  20. Updated Kinematic Constraints on a Dark Disk

    NASA Astrophysics Data System (ADS)

    Kramer, Eric David; Randall, Lisa

    2016-06-01

    We update the method of the Holmberg & Flynn study, including an updated model of the Milky Way’s interstellar gas, radial velocities, an updated reddening map, and a careful statistical analysis, to bound the allowed surface density and scale height of a dark disk. We pay careful attention to the self-consistency of the model, including the gravitational influence of the dark disk on other disk components, and to the net velocity of the tracer stars. We find that the data set exhibits a non-zero bulk velocity in the vertical direction as well as a displacement from the expected location at the Galactic midplane. If not properly accounted for, these features would bias the bound toward low dark disk mass. We therefore perform our analysis two ways. In the first, using the traditional method, we subtract the mean velocity and displacement from the tracers’ phase space distributions. In the second method, we perform a non-equilibrium version of the HF method to derive a bound on the dark disk parameters for an oscillating tracer distribution. Despite updates in the mass model and reddening map, the traditional method results remain consistent with those of HF2000. The second, non-equilibrium technique, however, allows a surface density as large as 14 {M}ȯ {{{pc}}}-2 (and as small as 0 {M}ȯ {{{pc}}}-2), demonstrating much weaker constraints. For both techniques, the bound on surface density is weaker for larger scale height. In future analyses of Gaia data it will be important to verify whether the tracer populations are in equilibrium.

  1. Paraneoplastic cutaneous manifestations: concepts and updates*

    PubMed Central

    da Silva, Josenilson Antônio; Mesquita, Kleyton de Carvalho; Igreja, Ana Carolina de Souza Machado; Lucas, Isabella Cristina Rodrigues Naves; Freitas, Aline Ferreira; de Oliveira, Sandra Maximiano; Costa, Izelda Maria Carvalho; Campbell, Iphis Tenfuss

    2013-01-01

    The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Although these dermatoses are relatively unusual, the recognition of some typical paraneoplastic dermatoses may lead to the early diagnosis of a neoplasm and determine a better prognosis. In this review article, we discuss the paraneoplastic cutaneous manifestations strongly associated with neoplasms, which include acanthosis nigricans maligna, tripe palms, erythema gyratum repens, Bazex syndrome, acquired hypertrichosis lanuginosa, necrolytic migratory erythema, Leser-Trélat sign and paraneoplastic pemphigus. We also review the clinical manifestations of each condition and include updated knowledge on disease pathogenesis. PMID:23538999

  2. Extracorporeal life support: updates and controversies.

    PubMed

    Gadepalli, Samir K; Hirschl, Ronald B

    2015-02-01

    The use of Extracorporeal Life Support (ECLS) in children and adults has markedly increased during the past few years with over 4000 patients placed on ECLS every year in over 200 centers. This article focuses on updates to the physiology and mechanics of ECLS with use of magnetically levitated centrifugal pumps, hollow-fiber gas-exchange devices, and bi-caval dual-lumen catheters. We also explore controversies in management including indications, cannulation approaches, renal replacement, monitoring of anticoagulation, early ambulation, and termination of ECLS. Finally, we present changes in the systems that provide ECLS including the single-provider model and regionalization of care. PMID:25639803

  3. Update on Vascular Dementia.

    PubMed

    Khan, Ayesha; Kalaria, Raj N; Corbett, Anne; Ballard, Clive

    2016-09-01

    Vascular dementia (VaD) is a major contributor to the dementia syndrome and is described as having problems with reasoning, planning, judgment, and memory caused by impaired blood flow to the brain and damage to the blood vessels resulting from events such as stroke. There are a variety of etiologies that contribute to the development of vascular cognitive impairment and VaD, and these are often associated with other dementia-related pathologies such as Alzheimer disease. The diagnosis of VaD is difficult due to the number and types of lesions and their locations in the brain. Factors that increase the risk of vascular diseases such as stroke, high blood pressure, high cholesterol, and smoking also raise the risk of VaD. Therefore, controlling these risk factors can help lower the chances of developing VaD. This update describes the subtypes of VaD, with details of their complex presentation, associated pathological lesions, and issues with diagnosis, prevention, and treatment. PMID:27502303

  4. Dali server update.

    PubMed

    Holm, Liisa; Laakso, Laura M

    2016-07-01

    The Dali server (http://ekhidna2.biocenter.helsinki.fi/dali) is a network service for comparing protein structures in 3D. In favourable cases, comparing 3D structures may reveal biologically interesting similarities that are not detectable by comparing sequences. The Dali server has been running in various places for over 20 years and is used routinely by crystallographers on newly solved structures. The latest update of the server provides enhanced analytics for the study of sequence and structure conservation. The server performs three types of structure comparisons: (i) Protein Data Bank (PDB) search compares one query structure against those in the PDB and returns a list of similar structures; (ii) pairwise comparison compares one query structure against a list of structures specified by the user; and (iii) all against all structure comparison returns a structural similarity matrix, a dendrogram and a multidimensional scaling projection of a set of structures specified by the user. Structural superimpositions are visualized using the Java-free WebGL viewer PV. The structural alignment view is enhanced by sequence similarity searches against Uniprot. The combined structure-sequence alignment information is compressed to a stack of aligned sequence logos. In the stack, each structure is structurally aligned to the query protein and represented by a sequence logo. PMID:27131377

  5. [Emergency departments - 2016 update].

    PubMed

    Zimmermann, M; Brokmann, J C; Gräff, I; Kumle, B; Wilke, P; Gries, A

    2016-04-01

    Acute medical care in hospital emergency departments has experienced rapid development in recent years and gained increasing importance not only from a professional medical point of view but also from an economic and health policy perspective. The present article therefore provides an update on the situation of emergency departments in Germany. Care in emergency departments is provided with an increasing tendency to patients of all ages presenting with varying primary symptoms, complaints, illnesses and injury patterns. In the process, patients reach the emergency department by various routes and structural provision. Cross-sectional communication and cooperation, prioritization and organization of emergency management and especially medical staff qualifications increasingly play a decisive role in this process. The range of necessary knowledge and skills far exceeds the scope of prehospital medical emergency care and the working environment differs substantially. In addition to existing structural and economic problems, the latest developments, as well as future proposals for the design of in-hospital emergency medical care in interdisciplinary emergency departments are described. PMID:26952123

  6. Gearbox Reliability Collaborative Update (Presentation)

    SciTech Connect

    Sheng, S.

    2013-10-01

    This presentation was given at the Sandia Reliability Workshop in August 2013 and provides information on current statistics, a status update, next steps, and other reliability research and development activities related to the Gearbox Reliability Collaborative.

  7. Email Updates: MedlinePlus

    MedlinePlus

    ... MedlinePlus emails from being marked as "spam" or "junk" To ensure that MedlinePlus email updates are delivered ... our emails from being marked as "spam" or "junk." About MedlinePlus Site Map FAQs Contact Us Get ...

  8. Facial transplantation: A concise update

    PubMed Central

    Barrera-Pulido, Fernando; Gomez-Cia, Tomas; Sicilia-Castro, Domingo; Garcia-Perla-Garcia, Alberto; Gacto-Sanchez, Purificacion; Hernandez-Guisado, Jose-Maria; Lagares-Borrego, Araceli; Narros-Gimenez, Rocio; Gonzalez-Padilla, Juan D.

    2013-01-01

    Objectives: Update on clinical results obtained by the first worldwide facial transplantation teams as well as review of the literature concerning the main surgical, immunological, ethical, and follow-up aspects described on facial transplanted patients. Study design: MEDLINE search of articles published on “face transplantation” until March 2012. Results: Eighteen clinical cases were studied. The mean patient age was 37.5 years, with a higher prevalence of men. Main surgical indication was gunshot injuries (6 patients). All patients had previously undergone multiple conventional surgical reconstructive procedures which had failed. Altogether 8 transplant teams belonging to 4 countries participated. Thirteen partial face transplantations and 5 full face transplantations have been performed. Allografts are varied according to face anatomical components and the amount of skin, muscle, bone, and other tissues included, though all were grafted successfully and remained viable without significant postoperative surgical complications. The patient with the longest follow-up was 5 years. Two patients died 2 and 27 months after transplantation. Conclusions: Clinical experience has demonstrated the feasibility of facial transplantation as a valuable reconstructive option, but it still remains considered as an experimental procedure with unresolved issues to settle down. Results show that from a clinical, technical, and immunological standpoint, facial transplantation has achieved functional, aesthetic, and social rehabilitation in severely facial disfigured patients. Key words:Face transplantation, composite tissue transplantation, face allograft, facial reconstruction, outcomes and complications of face transplantation. PMID:23229268

  9. Updated Evaluations for Americium Isotopes

    SciTech Connect

    Brown, D A; Pruet, J

    2005-09-22

    Here we describe evaluations for Am isotopes that will be included in the next release of ENDL. Current ENDL99 evaluations for these isotopes are quite outdated and almost entirely undocumented. Because Am is important for several DNT applications, and because quality evaluations are either readily available or easily calculated, the effort to update ENDL seems warranted. Results from good existing evaluations are adopted whenever possible. To this end we devote the next section of this report to a consideration of the availability of evaluations The quality of different evaluations as well as comparisons against experiments are also presented and used to motivate our choice of adopted data sets. Plans for modifying and improving adopted evaluations are also discussed. For {sup 240}Am there are no existing evaluations. To fill this gap, we are providing a new Am evaluation based on calculations with the statistical model reaction codes TALYS and EMPIRE. This evaluation is described below. The ENDF/B-VI formatted file containing this evaluation is given in the appendix.

  10. Cannabis and Psychopathology : Update 2004

    PubMed Central

    Grover, Sandeep; Basu, Debasish

    2004-01-01

    The study of cannabis use and psychopathology remains an interesting area from both academic and pragmatic perspectives. This article provides an update on the progress made in this area over the past decade or so. Psychopathology and psychiatric syndromes associated with cannabis use that have received research attention in recent years include cannabis withdrawal, cannabis and psychotic disorders (especially schizophrenia), depression, anxiety, and cognitive impairment. Status of a specific cannabis withdrawal syndrome and a specific ‘cannabis psychosis’ remains controversial. Current evidence indicates that there is a clinically significant association between cannabis use disorders and psychotic syndromes, depression, anxiety and possibly mild cognitive impairment. However, the nature of this association is often not clear. Several hypothesis related to the cannabis-schizophrenia association are examined. Cannabis use might be casually related to the later development of schizophrenia in an indirect way in a few heavy users, but more commonly, its use may precipitate disorders in persons who are vulnerable to developing psychosis and worsen the course of the disorder. PMID:21206788

  11. Bumper 3 Update for IADC Protection Manual

    NASA Technical Reports Server (NTRS)

    Christiansen, Eric L.; Nagy, Kornel; Hyde, Jim

    2016-01-01

    The Bumper code has been the standard in use by NASA and contractors to perform meteoroid/debris risk assessments since 1990. It has undergone extensive revisions and updates [NASA JSC HITF website; Christiansen et al., 1992, 1997]. NASA Johnson Space Center (JSC) has applied BUMPER to risk assessments for Space Station, Shuttle, Mir, Extravehicular Mobility Units (EMU) space suits, and other spacecraft (e.g., LDEF, Iridium, TDRS, and Hubble Space Telescope). Bumper continues to be updated with changes in the ballistic limit equations describing failure threshold of various spacecraft components, as well as changes in the meteoroid and debris environment models. Significant efforts are expended to validate Bumper and benchmark it to other meteoroid/debris risk assessment codes. Bumper 3 is a refactored version of Bumper II. The structure of the code was extensively modified to improve maintenance, performance and flexibility. The architecture was changed to separate the frequently updated ballistic limit equations from the relatively stable common core functions of the program. These updates allow NASA to produce specific editions of the Bumper 3 that are tailored for specific customer requirements. The core consists of common code necessary to process the Micrometeoroid and Orbital Debris (MMOD) environment models, assess shadowing and calculate MMOD risk. The library of target response subroutines includes a board range of different types of MMOD shield ballistic limit equations as well as equations describing damage to various spacecraft subsystems or hardware (thermal protection materials, windows, radiators, solar arrays, cables, etc.). The core and library of ballistic response subroutines are maintained under configuration control. A change in the core will affect all editions of the code, whereas a change in one or more of the response subroutines will affect all editions of the code that contain the particular response subroutines which are modified. Note

  12. Gap Assessment (FY 13 Update)

    DOE Data Explorer

    Getman, Dan

    2013-09-30

    To help guide its future data collection efforts, The DOE GTO funded a data gap analysis in FY2012 to identify high potential hydrothermal areas where critical data are needed. This analysis was updated in FY2013 and the resulting datasets are represented by this metadata. The original process was published in FY 2012 and is available here: https://pangea.stanford.edu/ERE/db/GeoConf/papers/SGW/2013/Esposito.pdf Though there are many types of data that can be used for hydrothermal exploration, five types of exploration data were targeted for this analysis. These data types were selected for their regional reconnaissance potential, and include many of the primary exploration techniques currently used by the geothermal industry. The data types include: 1. well data 2. geologic maps 3. fault maps 4. geochemistry data 5. geophysical data To determine data coverage, metadata for exploration data (including data type, data status, and coverage information) were collected and catalogued from nodes on the National Geothermal Data System (NGDS). It is the intention of this analysis that the data be updated from this source in a semi-automated fashion as new datasets are added to the NGDS nodes. In addition to this upload, an online tool was developed to allow all geothermal data providers to access this assessment and to directly add metadata themselves and view the results of the analysis via maps of data coverage in Geothermal Prospector (http://maps.nrel.gov/gt_prospector). A grid of the contiguous U.S. was created with 88,000 10-km by 10-km grid cells, and each cell was populated with the status of data availability corresponding to the five data types. Using these five data coverage maps and the USGS Resource Potential Map, sites were identified for future data collection efforts. These sites signify both that the USGS has indicated high favorability of occurrence of geothermal resources and that data gaps exist. The uploaded data are contained in two data files for

  13. Temporal transferability and updating of zonal level accident prediction models.

    PubMed

    Hadayeghi, Alireza; Shalaby, Amer S; Persaud, Bhagwant N; Cheung, Carl

    2006-05-01

    This paper examines the temporal transferability of the zonal accident prediction models by using appropriate evaluation measures of predictive performance to assess whether the relationship between the dependent and independent variables holds reasonably well across time. The two temporal contexts are the years 1996 and 2001, with updated 1996 models being used to predict 2001 accidents in each traffic zone of the City of Toronto. The paper examines alternative updating methods for temporal transfer by imagining that only a sample of 2001 data is available. The sensitivity of the performance of the updated models to the 2001 sample size is explored. The updating procedures examined include the Bayesian updating approach and the application of calibration factors to the 1996 models. Models calibrated for the 2001 samples were also explored, but were found to be inadequate. The results show that the models are not transferable in a strict statistical sense. However, relative measures of transferability indicate that the transferred models yield useful information in the application context. Also, it is concluded that the updated accident models using the calibration factors produce better results for predicting the number of accidents in the year 2001 than using the Bayesian approach. PMID:16414003

  14. Legislative Update, June 9, 2009. Report 09-20

    ERIC Educational Resources Information Center

    Blair, Julia

    2009-01-01

    This update contains analyses of legislative initiatives being tracked by staff of the California Postsecondary Education Commission. The positions shown for each bill are those adopted by the Commission at its June 9, 2009 and earlier meetings. A matrix of bills monitored by CPEC staff is included. Contents include: (1) Access; (2) Affordability;…

  15. Legislative Update, September 2010. Report 10-18

    ERIC Educational Resources Information Center

    Blair, Julia

    2010-01-01

    This update contains analyses of legislative initiatives being tracked by CPEC (California Postsecondary Education Commission) staff, including bills that have been introduced since the June Commission meeting. It has positions as adopted in the Commission meeting on September 28. A matrix of bills tracked by CPEC staff is included. Contents…

  16. Dutch Venous Ulcer guideline update.

    PubMed

    Maessen-Visch, M Birgitte; de Roos, Kees-Peter

    2014-05-19

    The revised guideline of 2013 is an update of the 2005 guideline "venous leg ulcer". In this special project four separate guidelines (venous leg ulcer, varicose veins, compression therapy and deep venous disorders) were revised and developed simultaneously. A meeting was held including representatives of any organisation involved in venous disease management including patient organizations and health insurance companies. Eighteen clinical questions where defined, and a new strategy was used to accelerate the process. This resulted in two new and two revised guidelines within one year. The guideline committee advises use of the C of the CEAP classification as well as the Venous Clinical Severity Score (VCSS) and a Quality of life (QoL) score in the assessment of clinical signs. These can provide insight into the burden of disease and the effects of treatment as experienced by the patient. A duplex ultrasound should be performed in every patient to establish the underlying aetiology and to evaluate the need for treatment (which is discussed in a separate guideline). The use of the TIME model for describing venous ulcers is recommended. There is no evidence for antiseptic or antibiotic wound care products except for a Cochrane review in which some evidence is presented for cadexomer iodine. Signs of infection are the main reason for the use of oral antibiotics. When the ulcer fails to heal the use of oral aspirin and pentoxifylline can be considered as an adjunct. For the individual patient, the following aspects should be considered: the appearance of the ulcer (amount of exudate) according to the TIME model, the influence of wound care products on moisturising the wound, frequency of changing compression bandages, pain and allergies. The cost of the dressings should also be considered. Education and training of patients t improves compliance with compression therapy but does not influence wound healing rates. PMID:24843102

  17. Recommendations of diagnosis and treatment of pleural effusion. Update.

    PubMed

    Villena Garrido, Victoria; Cases Viedma, Enrique; Fernández Villar, Alberto; de Pablo Gafas, Alicia; Pérez Rodríguez, Esteban; Porcel Pérez, José Manuel; Rodríguez Panadero, Francisco; Ruiz Martínez, Carlos; Salvatierra Velázquez, Angel; Valdés Cuadrado, Luis

    2014-06-01

    Although during the last few years there have been several important changes in the diagnostic or therapeutic methods, pleural effusion is still one of the diseases that the respiratory specialist have to evaluate frequently. The aim of this paper is to update the knowledge about pleural effusions, rather than to review the causes of pleural diseases exhaustively. These recommendations have a longer extension for the subjects with a direct clinical usefulness, but a slight update of other pleural diseases has been also included. Among the main scientific advantages are included the thoracic ultrasonography, the intrapleural fibrinolytics, the pleurodesis agents, or the new pleural drainages techniques. PMID:24698396

  18. Updated Electronic Testbed System

    NASA Technical Reports Server (NTRS)

    Brewer, Kevin L.

    2001-01-01

    updated Electronic Testbed System.

  19. Science Update: Inorganic Chemistry.

    ERIC Educational Resources Information Center

    Rawls, Rebecca

    1981-01-01

    Describes areas of inorganic chemistry which have changed dramatically in the past year or two, including photochemistry, electrochemistry, organometallic complexes, inorganic reaction theory, and solid state chemistry. (DS)

  20. Sweet Syndrome: A Review and Update.

    PubMed

    Villarreal-Villarreal, C D; Ocampo-Candiani, J; Villarreal-Martínez, A

    2016-06-01

    Sweet syndrome is the most representative entity of febrile neutrophilic dermatoses. It typically presents in patients with pirexya, neutrophilia, painful tender erytomatous papules, nodules and plaques often distributed asymmetrically. Frequent sites include the face, neck and upper extremities. Affected sites show a characteristical neutrophilic infiltrate in the upper dermis. Its etiology remains elucidated, but it seems that can be mediated by a hypersensitivity reaction in which cytokines, followed by infiltration of neutrophils, may be involved. Systemic corticosteroids are the first-line of treatment in most cases. We present a concise review of the pathogenesis, classification, diagnosis and treatment update of this entity. PMID:26826881

  1. Psychiatric treatments in dermatology: an update.

    PubMed

    Sambhi, R; Lepping, P

    2010-03-01

    There is a considerable degree of connection between psychiatry and dermatology. This connection is relevant both for diagnosis and management of dermatological pathology. This article summarises common psychiatric conditions seen in patients with skin disease, both primary psychiatric disorders and psychiatric disorders secondary to dermatological pathology. Diagnosis of relevant psychiatric conditions such as anxiety, depression, obsessive-compulsive disorder, delusional parasitosis and dermatitis artefacta, and psychiatric treatments are discussed. It gives an update of psychopharmacology relevant to the dermatologist including important interactions between psychotropic and dermatological agents. PMID:19874324

  2. Xanthones of Lichen Source: A 2016 Update.

    PubMed

    Le Pogam, Pierre; Boustie, Joël

    2016-01-01

    An update of xanthones encountered in lichens is proposed as more than 20 new xanthones have been described since the publication of the compendium of lichen metabolites by Huneck and Yoshimura in 1996. The last decades witnessed major advances regarding the elucidation of biosynthetic schemes leading to these fascinating compounds, accounting for the unique substitution patterns of a very vast majority of lichen xanthones. Besides a comprehensive analysis of the structures of xanthones described in lichens, their bioactivities and the emerging analytical strategies used to pinpoint them within lichens are presented here together with physico-chemical properties (including NMR data) as reported since 1996. PMID:26950106

  3. Urban area update procedures using Landsat data

    NASA Technical Reports Server (NTRS)

    Toll, D. L.; Royal, J. A.; Davis, J. B.

    1981-01-01

    Landsat digital enhancements and classification maps are shown to be useful for updating the urban expansion of standard metropolitan statistical areas on a macro scale. Automated procedures for detecting nonurban to urban land coverage change using multitemporal Landsat data are investigated for five metropolitan areas, showing an overall delineation similar to that obtained from large scale aerial photography. The evaluated change detection procedures include image differencing, principal component transformation prior to differencing, and post classification comparison. Results show that image differencing techniques in MSS band 5 provide the most accurate land cover change detections.

  4. Computer virus information update CIAC-2301

    SciTech Connect

    Orvis, W.J.

    1994-01-15

    While CIAC periodically issues bulletins about specific computer viruses, these bulletins do not cover all the computer viruses that affect desktop computers. The purpose of this document is to identify most of the known viruses for the MS-DOS and Macintosh platforms and give an overview of the effects of each virus. The authors also include information on some windows, Atari, and Amiga viruses. This document is revised periodically as new virus information becomes available. This document replaces all earlier versions of the CIAC Computer virus Information Update. The date on the front cover indicates date on which the information in this document was extracted from CIAC`s Virus database.

  5. Advanced MR Imaging of Gliomas: An Update

    PubMed Central

    Chiang, Shih-Wei; Chung, Hsiao-Wen; Tsai, Fong Y.; Chen, Cheng-Yu

    2013-01-01

    Recent advances in the treatment of cerebral gliomas have increased the demands on noninvasive neuroimaging for the diagnosis, therapeutic planning, tumor monitoring, and patient outcome prediction. In the meantime, improved magnetic resonance (MR) imaging techniques have shown much potentials in evaluating the key pathological features of the gliomas, including cellularity, invasiveness, mitotic activity, angiogenesis, and necrosis, hence, further shedding light on glioma grading before treatment. In this paper, an update of advanced MR imaging techniques is reviewed, and their potential roles as biomarkers of tumor grading are discussed. PMID:23862163

  6. Updated checklist of Iranian Opiinae (Hymenoptera: Braconidae).

    PubMed

    Gadallah, Neveen S; Ghahari, Hassan; Peris-Felipo, Francisco Javier; Fischer, Maximilian

    2016-01-01

    An updated checklist of Opiinae from Iran is provided including 101 species from 11 genera (Atormus van Achterberg, 1997, Biosteres Foerster, 1862, Eurytenes Forster, 1862, Fopius Wharton, 1987, Indiopius Fischer, 1966, Opius Wesmael, 1835, Phaedrotoma Forster, 1862, Pokomandya Fischer, 1959, Psyttalia Walker, 1860, Utetes Forster, 1862 and Xynobius Forster, 1862) belonging to two tribes (Biosterini and Opiini). Moreover, seven species Biosteres (Chilotrichia) punctiscuta (Thomson, 1895), Biosteres (Biosteres) remigii Fischer, 1971, Eurytenes (Eurytenes) abnormis (Wesmael, 1835), Opius (Hypocynodus) ponticus Fischer, 1958, Opius pygmaeator (Nees, 1811), Opius (Nosopoea) speciosus Fischer, 1959 and Phaedrotoma nitidulator (Nees, 1834) are recorded for the first time from Iran. PMID:27395527

  7. [An update on glucocorticoid-induced osteoporosis].

    PubMed

    Krasselt, Marco; Baerwald, Christoph

    2016-03-01

    Glucocorticoid-induced osteoporosis is the most common cause of secondary osteoporosis. Moreover, it is the most common reason for an osteoporosis among young adults. The clinical use of oral glucocorticoids increases the fracture incidence already within three months after starting the therapy. There does not seem to be a lower threshold: even doses as low as 2,5 mg of prednisone equivalent increase the risk of fractures. Adequate diagnostic and therapy are able to significantly reduce the resulting fracture risk. This article will discuss the pathophysiology of glucocorticoid-induced osteoporosis and give a summary of the current recommendations including the recently updated German guidelines. PMID:26939107

  8. School Law Update, 1985.

    ERIC Educational Resources Information Center

    Jones, Thomas N., Ed.; Semler, Darel P., Ed.

    A wide variety of contemporary legal issues, involving all levels of public and private education, are addressed in the 20 papers in this volume. Written in law review style and including legal citations, the papers and authors included are: (1) "Who Runs the Schools" (Flygare); (2) "Copyright Issues in Computer-Assisted Instruction" (Helm); (3)…

  9. Titan's Oxygen Chemistry: An Update

    NASA Astrophysics Data System (ADS)

    Hörst, S. M.; Klippenstein, S. J.; Lavvas, P.; Vuitton, V.; Yelle, R. V.

    2013-09-01

    Prior to the arrival of Cassini in the Saturn system, photochemical models were unable to simultaneously reproduce the observed abundances of CO, CO2, and H2O. The observations were explained by invoking an internal source of CO in addition to an external source of H2O or by assuming that the observed CO is the remnant of a larger primordial abundance. In 2008, we showed that the flux of O+ detected by the Cassini Plasma Spectrometer (CAPS) coupled with the previously known flux of H2O was sufficient to explain the oxygen bearing species in Titan's atmosphere [1]. This work demonstrated that it is no longer necessary to invoke outgassing from Titan's interior as a source for atmospheric CO or to assume that the observed CO is the remnant of a larger primordial abundance in Titan's atmosphere. Instead, it is most likely that the oxygen bearing species in Titan's atmosphere are the result of external input, most likely Enceladus. At the time, only one measurement of H2O existed, from the Infrared Space Observation (ISO) [2], which was roughly consistent with our model, as shown in Figure 1. Two recent observations, from the Cassini Composite Infrared Spectrometer (CIRS) [3] and Herschel [4], indicate that our 2008 model over predicts the abundance of water in Titan's atmosphere by an order of magnitude and the model of Moreno et al. 2012 was unable to simultaneously reproduce the abundance of all 3 species. The new observations indicate that photochemical models may be missing chemical and/or physical processes. It is therefore time to revisit the photochemical model, now with stronger constraints on the stratospheric H2O abundance, including the behavior as a function of altitude in the stratosphere, to ensure that the new observations do not point to a fundamental flaw in our understanding of Titan's atmosphere. We will present results from our recently updated model of Titan's oxygen chemistry.

  10. Updated Guidelines for ANSS Instruments

    NASA Astrophysics Data System (ADS)

    Evans, J. R.; Hutt, C. R.; Gee, L. S.

    2014-12-01

    In 2008 the Advanced National Seismic System (ANSS) of the U.S. Geological Survey (USGS) and cooperating universities and institutions issued USGS Open-File Report 2008-1262 (OFR) containing detailed guidelines for the performance of instrumentation to be used by the ANSS. Here we report an update underway to these guidelines to take account of lessons learned, changing technology, and expanding user desires; in a few instances, performance matters that are very hard to test in practice are either modified or removed. Instrument classes are defined in the OFR in terms of amplitude resolution and cost; because relevant technologies have advanced substantially in these six years and a number of groups have begun to explore the use of relatively inexpensive, entirely host installed and operated Class C systems, the guidelines for strong-motion sensors are being expanded to include detailed guidelines for them rather than just anticipating them. As always, Class A systems will form the state-of-the-art backbone of any network, with Class B filling in spatially and in areas otherwise not covered well. Class C systems would be an additional step in making networks denser by providing very inexpensive hardware, installation, and maintenance to fill in additionally between Class A and B sites, for example in a high-seismicity urban area, with Class A sites every 4-6 km, Class B every 2-3 km, and Class C at <1 km spacing. Class C devices would be both installed and maintained by hosts, not institutions, and therefore also would be economical for extending coverage in regions with widely spaced or rare large seismicity, such as the central and eastern U.S.

  11. Updated treatment algorithm of pulmonary arterial hypertension.

    PubMed

    Galiè, Nazzareno; Corris, Paul A; Frost, Adaani; Girgis, Reda E; Granton, John; Jing, Zhi Cheng; Klepetko, Walter; McGoon, Michael D; McLaughlin, Vallerie V; Preston, Ioana R; Rubin, Lewis J; Sandoval, Julio; Seeger, Werner; Keogh, Anne

    2013-12-24

    The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple and in some ways conflicting. The treatment algorithm usually includes different types of recommendations with varying degrees of scientific evidence. In addition, the algorithm is required to be comprehensive but not too complex, informative yet simple and straightforward. The type of information in the treatment algorithm are heterogeneous including clinical, hemodynamic, medical, interventional, pharmacological and regulatory recommendations. Stakeholders (or users) including physicians from various specialties and with variable expertise in PAH, nurses, patients and patients' associations, healthcare providers, regulatory agencies and industry are often interested in the PAH treatment algorithm for different reasons. These are the considerable challenges faced when proposing appropriate updates to the current evidence-based treatment algorithm.The current treatment algorithm may be divided into 3 main areas: 1) general measures, supportive therapy, referral strategy, acute vasoreactivity testing and chronic treatment with calcium channel blockers; 2) initial therapy with approved PAH drugs; and 3) clinical response to the initial therapy, combination therapy, balloon atrial septostomy, and lung transplantation. All three sections will be revisited highlighting information newly available in the past 5 years and proposing updates where appropriate. The European Society of Cardiology grades of recommendation and levels of evidence will be adopted to rank the proposed treatments. PMID:24355643

  12. The Molecular Biology Database Collection: 2004 update

    PubMed Central

    Galperin, Michael Y.

    2004-01-01

    The Molecular Biology Database Collection is a public resource listing key databases of value to the biologist, including those featured in this issue of Nucleic Acids Research, and other high-quality databases. All databases included in this Collection are freely available to the public. This listing aims to serve as a convenient starting point for searching the web for reliable information on various aspects of molecular biology, biochemistry and genetics. This year’s update includes 548 databases, 162 more than the previous one. The databases are organized in a hierarchical classification that should simplify finding the right database for each given task. Each database in the list comes with a recently updated brief description. The database list and the database descriptions can be accessed online at the Nucleic Acids Research web site http://nar.oupjournals.org/. The great challenge in biological research today is how to turn data into knowledge. I have met people who think data is knowledge but these people are then striving for a means of turning knowledge into understanding.Sydney Brenner. The Scientist 16[6]:12, March 18, 2002 PMID:14681349

  13. Restraint stress in biomedical research: an update.

    PubMed

    Glavin, G B; Paré, W P; Sandbak, T; Bakke, H K; Murison, R

    1994-01-01

    Since the publication of our initial review of restraint stress in 1986, much work has continued with this technique, either as a tool for the investigation of other pharmacological, physiological, or pathologic phenomena or with restraint stress itself serving as the object of the study. As we noted in 1986, the major use of restraint has been for the induction of stress responses in animals and, more specifically, for the investigation of drug effects, particularly as they affect typical stress-related pathology--gastrointestinal, neuroendocrine, and immunological agents have been extensively studied. In compiling this update on restraint stress and its effects, we noted an increasing emphasis on central nervous system mechanisms in peripheral disease, especially gastrointestinal disease. In particular, many CNS-active agents have been tested for their effects on gastric and duodenal lesion formation and gastric secretion, including antidepressants, antipsychotics, anxiolytics, noradrenergic, serotonergic, dopaminergic, and peptidergic compounds. Some of these agents are especially active in the gastrointestinal tract even when administered centrally, further solidifying the concept of a brain-gut axis. The present update includes studies of: methods and procedures, pre-restraint manipulations, post-restraint/healing effects, and drug effects. In addition, a current bibliography of reports that have employed restraint is included. PMID:8058215

  14. Simultaneous update of priority structures

    SciTech Connect

    Biswas, J.; Browne, J.C.

    1987-01-01

    To avoid centralized bottlenecks, data structures for multiple computer systems must be simultaneously updatable and yet must have some coherent and consistent state. This can be achieved through judicious partitioning of system data structures and control of access to them in such a manner that (1) either different processes operate upon disjoint segments of a given structure; or (2) processes operate upon the same datum object, in a controlled manner. Partitioning of data structures can be by structure or content. It can also occur at multiple times. In this paper we demonstrate content partitioning of a k-ary tree data structure at runtime, to realize a simultaneously updatable priority queue. The tree algorithms are then generalized to banyan data structures and shown to possess attractive properties of simultaneous update and throughput.

  15. The role of the neural reward circuitry in self-referential optimistic belief updates.

    PubMed

    Kuzmanovic, Bojana; Jefferson, Anneli; Vogeley, Kai

    2016-06-01

    People are motivated to adopt the most favorable beliefs about their future because positive beliefs are experienced as rewarding. However, it is so far inconclusive whether brain regions known to represent reward values are involved in the generation of optimistically biased belief updates. To address this question, we investigated neural correlates of belief updates that result in relatively better future outlooks, and therefore imply a positive subjective value of the judgment outcome. Participants estimated the probability of experiencing different adverse future events. After being provided with population base rates of these events, they had the opportunity to update their initial estimates. Participants made judgments concerning themselves or a similar other, and were confronted with desirable or undesirable base rates (i.e., lower or higher than their initial estimates). Belief updates were smaller following undesirable than desirable information, and this optimism bias was stronger for judgments regarding oneself than others. During updating, the positive value of self-related updates was reflected by neural activity in the subgenual ventromedial prefrontal cortex (vmPFC) that increased both with increasing sizes of favorable updates, and with decreasing sizes of unfavorable updates. During the processing of self-related undesirable base rates, increasing activity in a network including the dorsomedial PFC, hippocampus, thalamus and ventral striatum predicted decreasing update sizes. Thus, key regions of the neural reward circuitry contributed to the generation of optimistically biased self-referential belief updates. While the vmPFC tracked subjective values of belief updates, a network including the ventral striatum was involved in neglecting information calling for unfavorable updates. PMID:26883063

  16. Updating representations of temporal intervals.

    PubMed

    Danckert, James; Anderson, Britt

    2015-12-01

    Effectively engaging with the world depends on accurate representations of the regularities that make up that world-what we call mental models. The success of any mental model depends on the ability to adapt to changes-to 'update' the model. In prior work, we have shown that damage to the right hemisphere of the brain impairs the ability to update mental models across a range of tasks. Given the disparate nature of the tasks we have employed in this prior work (i.e. statistical learning, language acquisition, position priming, perceptual ambiguity, strategic game play), we propose that a cognitive module important for updating mental representations should be generic, in the sense that it is invoked across multiple cognitive and perceptual domains. To date, the majority of our tasks have been visual in nature. Given the ubiquity and import of temporal information in sensory experience, we examined the ability to build and update mental models of time. We had healthy individuals complete a temporal prediction task in which intervals were initially drawn from one temporal range before an unannounced switch to a different range of intervals. Separate groups had the second range of intervals switch to one that contained either longer or shorter intervals than the first range. Both groups showed significant positive correlations between perceptual and prediction accuracy. While each group updated mental models of temporal intervals, those exposed to shorter intervals did so more efficiently. Our results support the notion of generic capacity to update regularities in the environment-in this instance based on temporal information. The task developed here is well suited to investigations in neurological patients and in neuroimaging settings. PMID:26303026

  17. Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations

    PubMed Central

    Chassaing, N; Martin, L; Calvas, P; Le Bert, M; Hovnanian, A

    2005-01-01

    Pseudoxanthoma elasticum (PXE) is an inherited systemic disease of connective tissue primarily affecting the skin, retina, and cardiovascular system. It is characterised pathologically by elastic fibre mineralisation and fragmentation (so called "elastorrhexia"), and clinically by high heterogeneity in age of onset and the extent and severity of organ system involvement. PXE was recently associated with mutations in the ABCC6 (ATP binding cassette subtype C number 6) gene. At least one ABCC6 mutation is found in about 80% of patients. These mutations are identifiable in most of the 31 ABCC6 exons and consist of missense, nonsense, frameshift mutations, or large deletions. No correlation between the nature or location of the mutations and phenotype severity has yet been established. Recent findings support exclusive recessive inheritance. The proposed prevalence of PXE is 1/25 000, but this is probably an underestimate. ABCC6 encodes the protein ABCC6 (also known as MRP6), a member of the large ATP dependent transmembrane transporter family that is expressed predominantly in the liver and kidneys, and only to a lesser extent in tissues affected by PXE. The physiological substrates of ABCC6 remain to be determined, but the current hypothesis is that PXE should be considered to be a metabolic disease with undetermined circulating molecules interacting with the synthesis, turnover, or maintenance of elastic fibres. PMID:15894595

  18. An update on the role of medical treatment including antioxidant therapy in varicocele

    PubMed Central

    Garg, Harshit; Kumar, Rajeev

    2016-01-01

    Varicocele-associated male infertility has classically been managed using surgery or assisted reproductive techniques. With increasing evidence of oxidative stress as a pathophysiological factor in varicocele-associated infertility, medical therapy especially antioxidants might become a treatment option with lower risks. We reviewed the existing literature on the role of various medical agents in the management of male infertility attributed to varicoceles. Medical therapy is typically evaluated in three different situations such as (a) comparison of two drugs or one drug with placebo, (b) comparison of drugs versus surgery, and (c) comparison of drugs as adjuvant therapy with surgery versus drug therapy alone. Due to heterogeneity of data and lack of well-conducted studies, there is insufficient data to recommend routine use of medical therapy for men with varicocele-associated infertility and surgery remains the treatment of choice. Pregnancy and live birth rates are usually not reported in most studies and mere improvement in sperm parameters or antioxidant capacity is insufficient to support its routine use. Antioxidant therapy is a potential option due to its theoretical benefit, data from preclinical studies, and lack of major side effects. Adjuvant therapy with antioxidants after surgical repair of varicocele may improve the outcome and is a potential area for further research. PMID:26763549

  19. 78 FR 51664 - Vessel Traffic Service Updates, Including Establishment of Vessel Traffic Service Requirements...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    .... Abbreviations AIS Automatic Identification System FR Federal Register MMSI Maritime Mobile Service Identifier... implemented in 1994 (59 FR 36316, July 15, 1994), the Coast Guard instituted two VTS Special Areas within VTS... for Port Arthur, Texas and Expansion of VTS Special Operating Area in Puget Sound'' (77 FR 55439)....

  20. Update on tetralogy of Fallot for the adult cardiologist including a brief historical and surgical perspective.

    PubMed

    Kalra, Nishant; Klewer, Scott E; Raasch, Hannah; Sorrell, Vincent L

    2010-01-01

    There has been a steady rise in the prevalence of severe congenital heart disease (CHD) in adults because of improved treatment and survival during childhood. This has resulted in a shift in CHD morbidity and mortality beyond 18 years of age. The healthcare community must be prepared to meet this new challenge. Adult cardiologists need to be aware of common CHD, such as tetralogy of Fallot (TOF), as they will encounter adults with this CHD in their practice. With routine monitoring, cardiac imaging, early intervention, and treatment as highlighted in this report, continued improvement in the long-term fitness and avoidance of late complications for adult TOF patient is anticipated. PMID:20576040

  1. 75 FR 3617 - Outer Continental Shelf Air Regulations Update To Include New Jersey State Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... degrees longitude. \\1\\ The reader may refer to the Proposed Rulemaking, December 5, 1991 (56 FR 63774), and the preamble to the final rule promulgated September 4, 1992 (57 FR 40792) for further background and information on the OCS regulations. On October 2, 2009 (74 FR 50939), EPA proposed to...

  2. [Preoperative fasting guidelines: an update].

    PubMed

    López Muñoz, A C; Busto Aguirreurreta, N; Tomás Braulio, J

    2015-03-01

    Anesthesiology societies have issued various guidelines on preoperative fasting since 1990, not only to decrease the incidence of lung aspiration and anesthetic morbidity, but also to increase patient comfort prior to anesthesia. Some of these societies have been updating their guidelines, as such that, since 2010, we now have 2 evidence-based preoperative fasting guidelines available. In this article, an attempt is made to review these updated guidelines, as well as the current instructions for more controversial patients such as infants, the obese, and a particular type of ophthalmic surgery. PMID:25443866

  3. Updated plan for support of research related to geothermal reservoir engineering

    SciTech Connect

    Howard, J.H.; Goldstein, N.E.; Graf, A.N.

    1980-09-01

    The original plan for support of research in geothermal reservoir engineering, GREMP, is reviewed and compared with accomplishments to date. A commentary on the comparison and an updated plan are presented. Also included are a justification of the updated plan and a revised management plan. (MHR)

  4. Comprehensive Thematic T-matrix Reference Database: a 2013-2014 Update

    NASA Technical Reports Server (NTRS)

    Mishchenko, Michael I.; Zakharova, Nadezhda T.; Khlebtsov, Nikolai G.; Wriedt, Thomas; Videen, Gorden

    2014-01-01

    This paper is the sixth update to the comprehensive thematic database of peer-reviewedT-matrix publications initiated by us in 2004 and includes relevant publications that have appeared since 2013. It also lists several earlier publications not incorporated in the original database and previous updates.

  5. 75 FR 62810 - Twenty-Fourth Update of the Federal Agency Hazardous Waste Compliance Docket

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ... facilities not previously listed on the Docket and reported to EPA since the last update of the Docket (73 FR... facilities to be included on the Docket was published in the Federal Register on February 12, 1988 (53 FR 4280). Since then, updates to the Docket have been published on November 16, 1988 (54 FR...

  6. Trends in College Spending: 2001-2011. A Delta Data Update

    ERIC Educational Resources Information Center

    Desrochers, Donna M.; Hurlburt, Steven

    2014-01-01

    This "Trends in College Spending" update presents national-level estimates for the "Delta Cost Project" data metrics during the period 2001-11. To accelerate the release of more current trend data, however, this update includes only a brief summary of the financial patterns and trends observed during the decade 2001-11, with…

  7. 14 CFR 417.17 - Launch reporting requirements and launch specific updates.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., including the launch vehicle, planned flight path, staging and impact locations, and any on-orbit activity... modification under § 417.11. (3) Thirty-day flight safety analysis update. A launch operator must file updated flight safety analysis products, using previously approved methodologies, for each launch no later...

  8. An Update on Micrographics.

    ERIC Educational Resources Information Center

    Spaulding, Carl M.

    1978-01-01

    Reviews micrographic developments including relevant publications, applications, hardware, software, and films as they relate to library automation. Some observations are made on the competitive market situation characterizing the industry. (Author)

  9. ISS Update: Smart SPHERES

    NASA Video Gallery

    NASA Public Affairs Officer Kelly Humphries conducts a phone interview with Mark Micire, SPHERES Engineering Manager at Ames Research Center. Questions? Ask us on Twitter @NASA_Johnson and include ...

  10. Nutrition Update, 1978.

    ERIC Educational Resources Information Center

    Weininger, Jean; Briggs, George M.

    1978-01-01

    Reviews current nutrition research areas with important practical applications. Topics include hypertension, preventable birth defects, phenylketonuria and genetic diseases, new molecular genetics techniques, and saccharin and sweetners. Entries are brief and a 65-reference list is given. (MA)

  11. QUALITY ASSURANCE UPDATE

    EPA Science Inventory

    An overview of the air pollution quality assurance program as implemented by EMSL/RTP is presented. The discussion includes method standardization operations for both ambient air and stationary source measurements, the quality assurance audit program, the ambient air equivalency ...

  12. Science Update: Inorganic Chemistry

    ERIC Educational Resources Information Center

    Rawls, Rebecca

    1978-01-01

    This first in a series of articles describing the state of the art of various branches of chemistry reviews inorganic chemistry, including bioinorganic, photochemistry, organometallic, and solid state chemistries. (SL)

  13. ISS Update: Supermoon

    NASA Video Gallery

    Public Affairs Officer Kyle Herring narrates video of the "supermoon" captured from the International Space Station during Expedition 31. Questions? Ask us on Twitter @NASA_Johnson and include the ...

  14. Breast Cancer and Estrogen-Alone Update

    MedlinePlus

    ... Current Issue Past Issues Research News From NIH Breast Cancer and Estrogen-Alone Update Past Issues / Summer 2006 ... hormone therapy does not increase the risk of breast cancer in postmenopausal women, according to an updated analysis ...

  15. Seborrheic dermatitis: an update.

    PubMed

    Bukvić Mokos, Zrinka; Kralj, Martina; Basta-Juzbašić, Aleksandra; Lakoš Jukić, Ines

    2012-01-01

    Seborrheic dermatitis is a chronic relapsing inflammatory skin disorder clinically characterized by scaling and poorly defined erythematous patches. The prevalence of adult seborrheic dermatitis is estimated at 5%. Although the exact cause of seborrheic dermatitis has yet to be understood, Malassezia yeasts, hormones (androgens), sebum levels and immune response are known to play important roles in its development. Additional factors including drugs, winter temperatures and stress may exacerbate seborrheic dermatitis. A variety of treatment modalities are available, including antifungal agents, topical low-potency steroids and calcineurin inhibitors (immunomodulators). This review summarizes current knowledge on the etiopathogenesis and therapy of adult seborrheic dermatitis. PMID:22726283

  16. An Update on the CDDIS

    NASA Technical Reports Server (NTRS)

    Noll, Carey; Michael, Patrick; Dube, Maurice P.; Pollack, N.

    2012-01-01

    incoming data and product files pushed to its archive. This poster will include background information about the system and its user communities, archive contents and updates, enhancements for data discovery, new system architecture, and future plans.

  17. Endocrine Dysregulation in Anorexia Nervosa Update

    PubMed Central

    2011-01-01

    Context: Anorexia nervosa is a primary psychiatric disorder with serious endocrine consequences, including dysregulation of the gonadal, adrenal, and GH axes, and severe bone loss. This Update reviews recent advances in the understanding of the endocrine dysregulation observed in this state of chronic starvation, as well as the mechanisms underlying the disease itself. Evidence Acquisition: Findings of this update are based on a PubMed search and the author's knowledge of this field. Evidence Synthesis: Recent studies have provided insights into the mechanisms underlying endocrine dysregulation in states of chronic starvation as well as the etiology of anorexia nervosa itself. This includes a more complex understanding of the pathophysiologic bases of hypogonadism, hypercortisolemia, GH resistance, appetite regulation, and bone loss. Nevertheless, the etiology of the disease remains largely unknown, and effective therapies for the endocrine complications and for the disease itself are lacking. Conclusions: Despite significant progress in the field, further research is needed to elucidate the mechanisms underlying the development of anorexia nervosa and its endocrine complications. Such investigations promise to yield important advances in the therapeutic approach to this disease as well as to the understanding of the regulation of endocrine function, skeletal biology, and appetite regulation. PMID:21976742

  18. Task Group 9 Update (Presentation)

    SciTech Connect

    Bosco, N.

    2014-04-01

    This presentation is a brief update of IEC TC82 QA Task Force, Group 9. Presented is an outline of the recently submitted New Work Item Proposal (NWIP) for a Comparative Thermal Cycling Test for CPV Modules to Differentiate Thermal Fatigue Durability.

  19. National Educators' Workshop: Update 1996

    NASA Technical Reports Server (NTRS)

    Gardner, James E.; Freeman, Ginger L.; Jacobs, James; Parkin, Don M.

    1997-01-01

    This document contains a collection of experiments presented and demonstrated at the National Educators' Workshop: Update 96, held at Los Alamos National Laboratory, Los Alamos, New Mexico on October 27-30, 1996. The experiments related to the nature and properties of engineering materials and provided information to assist in teaching about materials in the education community.

  20. NUHOMS{reg_sign} update

    SciTech Connect

    Rich, N.

    1995-12-31

    NUHOMS{reg_sign} is the dry spent fuel storage and transportation technology selected to date by the majority of commercial nuclear utilities. The author first gives a system overview of the NUHOMS{reg_sign}. Next she discusses the project status and licensing status. She closes with an update of the multi-purpose canister.

  1. Austin Community College Benchmarking Update.

    ERIC Educational Resources Information Center

    Austin Community Coll., TX. Office of Institutional Effectiveness.

    Austin Community College contracted with MGT of America, Inc. in spring 1999 to develop a peer and benchmark (best) practices analysis on key indicators. These indicators were updated in spring 2002 using data from eight Texas community colleges and four non-Texas institutions that represent large, comprehensive, urban community colleges, similar…

  2. A Mathematics Software Database Update.

    ERIC Educational Resources Information Center

    Cunningham, R. S.; Smith, David A.

    1987-01-01

    Contains an update of an earlier listing of software for mathematics instruction at the college level. Topics are: advanced mathematics, algebra, calculus, differential equations, discrete mathematics, equation solving, general mathematics, geometry, linear and matrix algebra, logic, statistics and probability, and trigonometry. (PK)

  3. Censorship in Massachusetts: An Update.

    ERIC Educational Resources Information Center

    Woods, L. B.; O'Brien, Jane E.

    This report updates a 1979 article from the Bay State Librarian about censorship in Massachusetts libraries from 1966 through 1975. Compiled using data from the American Library Association's Office of Intellectual Freedom (OIF), the report provides information about censorship attempts and actions between 1976 and 1982. The definition of…

  4. Competitive Electricity Prices: An Update

    EIA Publications

    1998-01-01

    Illustrates a third impact of the move to competitive generation pricing -- the narrowing of the range of prices across regions of the country. This feature article updates information in Electricity Prices in a Competitive Environment: Marginal Cost Pricing of Generation Services and Financial Status of Electric Utilities.

  5. Deductive Updating Is Not Bayesian

    ERIC Educational Resources Information Center

    Markovits, Henry; Brisson, Janie; de Chantal, Pier-Luc

    2015-01-01

    One of the major debates concerning the nature of inferential reasoning is between counterexample-based theories such as mental model theory and probabilistic theories. This study looks at conclusion updating after the addition of statistical information to examine the hypothesis that deductive reasoning cannot be explained by probabilistic…

  6. Progress Update: Stack Project Complete

    ScienceCinema

    Cody, Tom

    2012-06-14

    Progress update from the Savannah River Site. The 75 foot 293 F Stack, built for plutonium production, was cut down to size in order to prevent injury or release of toxic material if the structure were to collapse due to harsh weather.

  7. National Drug Control Strategy. Update

    ERIC Educational Resources Information Center

    Office of National Drug Control Policy, 2005

    2005-01-01

    The first National Drug Control Strategy set ambitious two and five-year performance based goals: (1) to lower the rate of drug use by 10 percent over 2 years among both youth and adults; and (2) to lower the rate by 25 percent over 5 years. The chapters in this updated version are keyed to the strategies three priorities: (1) Stopping Use Before…

  8. Progress Update: Stack Project Complete

    SciTech Connect

    Cody, Tom

    2010-01-01

    Progress update from the Savannah River Site. The 75 foot 293 F Stack, built for plutonium production, was cut down to size in order to prevent injury or release of toxic material if the structure were to collapse due to harsh weather.

  9. Vitamin E: Textbooks Require Updating

    ERIC Educational Resources Information Center

    Azzi, Angelo; Zingg, Jean-Marc

    2005-01-01

    Vitamin E was discovered in 1922, but in more than 60 years many new findings have added to the early one. However, its description in many textbooks has not been proportionally updated. The result is an inaccurate, incomplete, and often incorrect description of the function of this vitamin. In some other textbooks, vitamin E is absolutely…

  10. School Law Update--1977.

    ERIC Educational Resources Information Center

    McGhehey, M. A., Ed.

    This book is a collection of 26 addresses made at the 23rd annual convention of the National Organization on Legal Problems of Education. It discusses issues surrounding school law in elementary, secondary, and higher education in 1977 and before. Some of the topics covered include collective bargaining, employee layoff, sex discrimination and…

  11. Update: Saudi Arabia.

    ERIC Educational Resources Information Center

    McGregor, Joy; Nydell, Margaret

    A guide for persons planning on living in or relocating to Saudi Arabia for extended periods of time, this book features information on such topics as entry requirements, transportation, money matters, housing, schools, and insurance. The guide's contents include the following sections: (1) an overview; (2) before leaving; (3) on arrival; (4)…

  12. RCC NDE Update

    NASA Technical Reports Server (NTRS)

    Hernandez, Jose M.

    2004-01-01

    This slide presentation reviews non-destructive evaluation (NDE) techniques of Reinforced Carbon-Carbon (RCC) materials and the progress involved in bringing the technology to technological maturity. Included is information about the test specimens, thermographic, ultrasonic, eddy current, and radiographic inspection of RCC materials.

  13. Student Leadership. Prevention Updates

    ERIC Educational Resources Information Center

    Langford, Linda; DeJong, William

    2010-01-01

    Campus-based efforts to reduce alcohol and other drug abuse and violence (AODV) will be more successful if they involve a wide range of stakeholders--including students--who can contribute to the program's design, implementation, and evaluation. Students provide a unique perspective on AODV prevention, and they can also bring a certain authority…

  14. Multimodel Counseling: An Update.

    ERIC Educational Resources Information Center

    Keat, Donald B., II, Ed.

    1982-01-01

    Contains six articles focusing on current developments in multimodal counseling. Topics addressed include multimodal methods of interviewing children, helping children with anger, and enhancing self-concept. Describes utilizing helping books with children, and the multimodal effect of physical exercise. (RC)

  15. Update on World Development.

    ERIC Educational Resources Information Center

    Social Education, 1996

    1996-01-01

    Summarizes a wealth of statistical information concerning the economic development and debt for a number of developing nations. Includes statistics on the gross national product growth of Cote d'lvoire, Guatemala, Malaysia, Korea, Colombia, and Nigeria, as well as, the gross domestic product growth and debt service for Latin America, Africa, and…

  16. Computer Viruses. Technology Update.

    ERIC Educational Resources Information Center

    Ponder, Tim, Comp.; Ropog, Marty, Comp.; Keating, Joseph, Comp.

    This document provides general information on computer viruses, how to help protect a computer network from them, measures to take if a computer becomes infected. Highlights include the origins of computer viruses; virus contraction; a description of some common virus types (File Virus, Boot Sector/Partition Table Viruses, Trojan Horses, and…

  17. Document Delivery Update.

    ERIC Educational Resources Information Center

    Nelson, Nancy Melin

    1992-01-01

    Presents highlights of research that used industrywide surveys, focus groups, personal interviews, and industry-published data to explore the future of electronic information delivery in libraries. Topics discussed include CD-ROMs; prices; full-text products; magnetic tape leasing; engineering and technical literature; connections between online…

  18. Career Update: Moving Up.

    ERIC Educational Resources Information Center

    Thomas, Irene Middleman

    1992-01-01

    Discusses corporate hiring and promotion of Hispanic Americans. Interview respondents discuss their Hispanic backgrounds, education, and corporate practices that helped advance their careers. Subjects include executives at SmithKline Beecham (Philadelphia), IBM, John F. Kennedy School of Government (Harvard), Aetna Life and Casualty, and Chase…

  19. Bowland Maths--Update

    ERIC Educational Resources Information Center

    Thompson, Quentin

    2011-01-01

    The March issue of "Mathematics Teaching" included an article by Alice Onion about Bowland Maths, focussing on the nature and use of the Professional Development modules that the Bowland Trust has developed--there are now seven such CPD modules on the Bowland website. The article also mentioned that the Bowland Trust had recently conducted a…

  20. Lupus nephritis: an update.

    PubMed

    Imran, Tasnim F; Yick, Frederick; Verma, Suneet; Estiverne, Christopher; Ogbonnaya-Odor, Chinonye; Thiruvarudsothy, Srikanth; Reddi, Alluru S; Kothari, Neil

    2016-02-01

    Lupus nephritis (LN) is an inflammatory condition of the kidneys that encompasses various patterns of renal disease including glomerular and tubulointerstitial pathology. It is a major predictor of poor prognosis in patients with systemic lupus erythematosus (SLE). Genetic factors, including several predisposing loci, and environmental factors, such as EBV and ultraviolet light, have been implicated in the pathogenesis. It carries a high morbidity and mortality if left untreated. Renal biopsy findings are utilized to guide treatment. Optimizing risk factors such as proteinuria and hypertension with renin-angiotensin receptor blockade is crucial. Immunosuppressive therapy is recommended for patients with focal or diffuse proliferative lupus nephritis (Class III or IV) disease, and certain patients with membranous LN (Class V) disease. Over the past decade, immunosuppressive therapies have significantly improved long-term outcomes, but the optimal therapy for LN remains to be elucidated. Cyclophosphamide-based regimens, given concomitantly with corticosteroids, have improved survival significantly. Even though many patients achieve remission, the risk of relapse remains considerably high. Other treatments include hydroxychloroquine, mycofenolate mofetil, and biologic therapies such as Belimumab, Rituximab, and Abatacept. In this paper, we provide a review of LN, including pathogenesis, classification, and clinical manifestations. We will focus, though, on discussion of the established as well as emerging therapies for patients with proliferative and membranous lupus nephritis. PMID:26471017

  1. Update Hong Kong.

    ERIC Educational Resources Information Center

    Bennett, Martin F.

    This book is a guide intended for persons planning on relocating to Hong Kong. Following an overview of the history and culture of Hong Kong, 12 additional chapters lead the reader step-by-step through the relocation process. These chapter topics include: before leaving, on arrival, language, doing business in Hong Kong, customs and courtesies,…

  2. Updates in oncology.

    PubMed

    Sculier, Jean-Paul; Meert, Anne-Pascale; Berghmans, Thierry

    2014-03-01

    The objective of this review is to report the Clinical Year in Review proceedings in the field of thoracic oncology that were presented at the 2013 European Respiratory Society Annual Congress in Barcelona, Spain. Various topics were reviewed, including: epidemiology, screening, histology, and treatment of nonsmall cell lung cancer and small cell lung cancer. PMID:24591664

  3. Periviable birth: Interim update.

    PubMed

    Ecker, Jeffrey L; Kaimal, Anjali; Mercer, Brian M; Blackwell, Sean C; deRegnier, Raye Ann O; Farrell, Ruth M; Grobman, William A; Resnik, Jamie L; Sciscione, Anthony C

    2016-08-01

    Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth. These include, but are not limited to, nonmodifiable factors (eg, fetal sex, weight, plurality), potentially modifiable antepartum and intrapartum factors (eg, location of delivery, intent to intervene by cesarean delivery or induction for delivery, administration of antenatal corticosteroids and magnesium sulfate), and postnatal management (eg, starting or withholding and continuing or withdrawing intensive care after birth). Antepartum and intrapartum management options vary depending upon the specific circumstances but may include short-term tocolytic therapy for preterm labor to allow time for administration of antenatal steroids, antibiotics to prolong latency after preterm premature rupture of membranes or for intrapartum group B streptococci prophylaxis, and delivery, including cesarean delivery, for concern regarding fetal well-being or fetal malpresentation. Whenever possible, periviable births for which maternal or neonatal intervention is planned should occur in centers that offer expertise in maternal and neonatal care and the needed infrastructure, including intensive care units, to support such services. This document describes newborn outcomes after periviable birth, provides current evidence and recommendations regarding interventions in this setting, and provides an outline for family counseling with the goal of

  4. Recommendations for kidney disease guideline updating: a report by the KDIGO Methods Committee.

    PubMed

    Uhlig, Katrin; Berns, Jeffrey S; Carville, Serena; Chan, Wiley; Cheung, Michael; Guyatt, Gordon H; Hart, Allyson; Lewis, Sandra Zelman; Tonelli, Marcello; Webster, Angela C; Wilt, Timothy J; Kasiske, Bertram L

    2016-04-01

    Updating rather than de novo guideline development now accounts for the majority of guideline activities for many guideline development organizations, including Kidney Disease: Improving Global Outcomes (KDIGO), an international kidney disease guideline development entity that has produced guidelines on kidney diseases since 2008. Increasingly, guideline developers are moving away from updating at fixed intervals in favor of more flexible approaches that use periodic expert assessment of guideline currency (with or without an updated systematic review) to determine the need for updating. Determining the need for guideline updating in an efficient, transparent, and timely manner is challenging, and updating of systematic reviews and guidelines is labor intensive. Ideally, guidelines should be updated dynamically when new evidence indicates a need for a substantive change in the guideline based on a priori criteria. This dynamic updating (sometimes referred to as a living guideline model) can be facilitated with the use of integrated electronic platforms that allow updating of specific recommendations. This report summarizes consensus-based recommendations from a panel of guideline methodology professionals on how to keep KDIGO guidelines up to date. PMID:26994574

  5. Legislative Update, December 2010. Report 10-21

    ERIC Educational Resources Information Center

    Blair, Julia

    2010-01-01

    This update contains the Governor's action on legislative initiatives being tracked by CPEC (California Postsecondary Education Commission) staff in the 2009-10 legislative session and information on the new members of the Legislature. A summary matrix of bills monitored by CPEC staff is included.

  6. Legislative Update, June 2011. Report 11-06

    ERIC Educational Resources Information Center

    Blair, Julia

    2011-01-01

    This report updates the status of bills that the California Postsecondary Education Commission (CPEC) is tracking. It has positions as adopted by the Commission at its June 14, 2011 and earlier meetings. A matrix of bills tracked by CPEC staff is included.

  7. Legislative Update, September 2009. Report 09-25

    ERIC Educational Resources Information Center

    Blair, Julia

    2009-01-01

    This update contains analyses of legislative initiatives being tracked by California Postsecondary Education Commission (CPEC) staff. The positions indicated are those adopted by the Commission at the September 8, 2009, and earlier meetings. A matrix of bills monitored by CPEC staff is included.

  8. Dropouts and Retention in Vocational Education Programs. A Bibliography Update.

    ERIC Educational Resources Information Center

    Florida State Univ., Tallahassee. Center for Instructional Development and Services.

    This bibliography update contains information on dropout attitudes, prevention, programs, rates, and research, as well as school-holding power at the secondary and postsecondary levels. Citations include conference papers, program descriptions, research reports, and statistical materials. Materials for inclusion in this bibliography were located…

  9. Business/Industry/Education Linkages. A Bibliography Update.

    ERIC Educational Resources Information Center

    Florida State Univ., Tallahassee. Center for Instructional Development and Services.

    This annotated bibliography update contains 61 citations, the primary focus of which is on postsecondary-level linkages between schools/colleges and business/industry. Many citations are specific to vocational education. Citations include administrative material, journal articles, opinion papers, project descriptions, and reports. Materials for…

  10. Political Education: National Policy Comes of Age. The Updated Edition

    ERIC Educational Resources Information Center

    Cross, Christopher T.

    2010-01-01

    Political insider Christopher Cross has updated his critically acclaimed book to reflect recent education policy developments, including the impact of the Obama administration and "Race to the Top" as well as the controversy over NCLB's reauthorization. Featuring a new introduction and the addition of postscripts for key chapters, this important…

  11. Updated Photonuclear Data Library and Database for Photon Strength Functions

    NASA Astrophysics Data System (ADS)

    Dimitriou, Paraskevi; Firestone, Richard B.; Siem, Sunniva; Bečvár, František; Krtička, Milan; Varlamov, Vladimir V.; Wiedeking, Mathis

    2015-05-01

    Photonuclear cross sections and gamma-ray data used to extract Photon Strength Functions are important for a large range of applications including basic sciences. The recommendations of an IAEA Consultant's Meeting to update the IAEA Photonuclear Data Library and create a Reference Database for Photon Strength Functions are presented.

  12. 29 CFR 1904.33 - Retention and updating.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... RECORDING AND REPORTING OCCUPATIONAL INJURIES AND ILLNESSES Other OSHA Injury and Illness Recordkeeping... must update your stored OSHA 300 Logs to include newly discovered recordable injuries or illnesses and... illnesses. If the description or outcome of a case changes, you must remove or line out the original...

  13. 29 CFR 1904.33 - Retention and updating.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... RECORDING AND REPORTING OCCUPATIONAL INJURIES AND ILLNESSES Other OSHA Injury and Illness Recordkeeping... must update your stored OSHA 300 Logs to include newly discovered recordable injuries or illnesses and... illnesses. If the description or outcome of a case changes, you must remove or line out the original...

  14. 29 CFR 1904.33 - Retention and updating.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... RECORDING AND REPORTING OCCUPATIONAL INJURIES AND ILLNESSES Other OSHA Injury and Illness Recordkeeping... must update your stored OSHA 300 Logs to include newly discovered recordable injuries or illnesses and... illnesses. If the description or outcome of a case changes, you must remove or line out the original...

  15. 29 CFR 1904.33 - Retention and updating.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... RECORDING AND REPORTING OCCUPATIONAL INJURIES AND ILLNESSES Other OSHA Injury and Illness Recordkeeping... must update your stored OSHA 300 Logs to include newly discovered recordable injuries or illnesses and... illnesses. If the description or outcome of a case changes, you must remove or line out the original...

  16. 29 CFR 1904.33 - Retention and updating.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... RECORDING AND REPORTING OCCUPATIONAL INJURIES AND ILLNESSES Other OSHA Injury and Illness Recordkeeping... must update your stored OSHA 300 Logs to include newly discovered recordable injuries or illnesses and... illnesses. If the description or outcome of a case changes, you must remove or line out the original...

  17. Continuous flow measurements using ultrasonic velocity meters - an update

    USGS Publications Warehouse

    Oltmann, Rick

    1995-01-01

    An article in the summer 1993 Newsletter described USGS work to continously monitor tidal flows in the delta using ultrasonic velocity meters.  This article updates progress since 1993, including new installations, results of data analysis, damage during this year's high flows, and the status of each site.

  18. 10 CFR 603.885 - Updated program plans and budgets.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Updated program plans and budgets. 603.885 Section 603.885... program plans and budgets. In addition to reports on progress to date, a TIA may include a provision... effort and a revised budget if there is a significant change from the initial budget....

  19. 10 CFR 603.885 - Updated program plans and budgets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Updated program plans and budgets. 603.885 Section 603.885... program plans and budgets. In addition to reports on progress to date, a TIA may include a provision... effort and a revised budget if there is a significant change from the initial budget....

  20. 10 CFR 603.885 - Updated program plans and budgets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Updated program plans and budgets. 603.885 Section 603.885... program plans and budgets. In addition to reports on progress to date, a TIA may include a provision... effort and a revised budget if there is a significant change from the initial budget....

  1. 10 CFR 603.885 - Updated program plans and budgets.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Updated program plans and budgets. 603.885 Section 603.885... program plans and budgets. In addition to reports on progress to date, a TIA may include a provision... effort and a revised budget if there is a significant change from the initial budget....

  2. 10 CFR 603.885 - Updated program plans and budgets.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Updated program plans and budgets. 603.885 Section 603.885... program plans and budgets. In addition to reports on progress to date, a TIA may include a provision... effort and a revised budget if there is a significant change from the initial budget....

  3. Fiscal Profiles Update, 2007. Commission Report 07-16

    ERIC Educational Resources Information Center

    California Postsecondary Education Commission, 2007

    2007-01-01

    Fiscal Profiles, 2007, is an excerpt of selected displays updated from the last full report in 2006. This set of displays includes information on overall State funding, public higher education funding and enrollments, and California's independent higher education institutions. As of the publication date for this report, the California State…

  4. Comparison of update algorithms for pure Gauge SU(3)

    SciTech Connect

    Gupta, R.; Kilcup, G.W.; Patel, A.; Sharpe, S.R.; Deforcrand, P.

    1988-10-01

    The authors show that the overrelaxed algorithm of Creutz and of Brown and Woch is the optimal local update algorithm for simulation of pure gauge SU(3). The authors' comparison criterion includes computer efficiency and decorrelation times. They also investigate the rate of decorrelation for the Hybrid Monte Carlo algorithm.

  5. Highlights of the University of Toronto Urology Update 2014

    PubMed Central

    Herschorn, Sender

    2015-01-01

    At the University of Toronto Urology Update 2014, a faculty of Canadian and American experts presented a series of lectures covering a range of topics in the field of urology. Areas of focus included prostate cancer (PCa), functional urology, erectile dysfunction (ED), and surgical topics (e.g., percutaneous nephrolithotomy [PCNL]). PMID:25784963

  6. Documentation of structures branch programs and program updates. Project 3200

    NASA Technical Reports Server (NTRS)

    Probe, D. G.

    1975-01-01

    Update programming of applications programs for the integrated structural analysis system is reported. An attempt is made to layout a standard document format for the preparation of program documents. Documentation which involves changes, additions, and I/O capability revisions to existing programs includes a checklist which should be reviewed each time a programming effort is documented.

  7. Calculation and Updating of Reliability Parameters in Probabilistic Safety Assessment

    NASA Astrophysics Data System (ADS)

    Zubair, Muhammad; Zhang, Zhijian; Khan, Salah Ud Din

    2011-02-01

    The internal events of nuclear power plant are complex and include equipment maintenance, equipment damage etc. These events will affect the probability of the current risk level of the system as well as the reliability of the equipment parameter values so such kind of events will serve as an important basis for systematic analysis and calculation. This paper presents a method for reliability parameters calculation and their updating. The method is based on binomial likelihood function and its conjugate beta distribution. For update parameters Bayes' theorem has been selected. To implement proposed method a computer base program is designed which provide help to estimate reliability parameters.

  8. 40 CFR 55.12 - Consistency updates.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 6 2013-07-01 2013-07-01 false Consistency updates. 55.12 Section 55.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) OUTER CONTINENTAL SHELF AIR REGULATIONS § 55.12 Consistency updates. (a) The Administrator will update this part as necessary to maintain...

  9. Neural dissociations between meaningful and mere inconsistency in impression updating.

    PubMed

    Mende-Siedlecki, Peter; Todorov, Alexander

    2016-09-01

    Recent neuroimaging work has identified a network of regions that work in concert to update impressions of other people, particularly in response to inconsistent behavior. However, the specific functional contributions of these regions to the updating process remain unclear. Using fMRI, we tested whether increases in activity triggered by inconsistent behavior reflect changes in the stored representations of other people in response to behavioral inconsistency, or merely a response to the inconsistency itself. Participants encountered a series of individuals whose behavior either changed in an attributionally meaningful fashion or was merely inconsistent with the immediately preceding behavior. We observed that left ventrolateral prefrontal cortex (vlPFC) and left inferior frontal gyrus (IFG) were preferentially recruited in response to unexpected, immoral behavior, whereas a separate set of regions (including dorsal anterior cingulate cortex, posterior cingulate cortex and temporoparietal junction/inferior parietal lobule) was preferentially recruited in response to more mundane inconsistencies in behavior. These results shed light on the distributed systems supporting impression updating. Specifically, while many regions supporting updating may primarily respond to moment-to-moment changes in behavior, a subset of regions (e.g. vlPFC and IFG) may contribute to updating person representations in response to trait-relevant changes in behavior. PMID:27217118

  10. Updating National Topographic Data Base Using Change Detection Methods

    NASA Astrophysics Data System (ADS)

    Keinan, E.; Felus, Y. A.; Tal, Y.; Zilberstien, O.; Elihai, Y.

    2016-06-01

    The traditional method for updating a topographic database on a national scale is a complex process that requires human resources, time and the development of specialized procedures. In many National Mapping and Cadaster Agencies (NMCA), the updating cycle takes a few years. Today, the reality is dynamic and the changes occur every day, therefore, the users expect that the existing database will portray the current reality. Global mapping projects which are based on community volunteers, such as OSM, update their database every day based on crowdsourcing. In order to fulfil user's requirements for rapid updating, a new methodology that maps major interest areas while preserving associated decoding information, should be developed. Until recently, automated processes did not yield satisfactory results, and a typically process included comparing images from different periods. The success rates in identifying the objects were low, and most were accompanied by a high percentage of false alarms. As a result, the automatic process required significant editorial work that made it uneconomical. In the recent years, the development of technologies in mapping, advancement in image processing algorithms and computer vision, together with the development of digital aerial cameras with NIR band and Very High Resolution satellites, allow the implementation of a cost effective automated process. The automatic process is based on high-resolution Digital Surface Model analysis, Multi Spectral (MS) classification, MS segmentation, object analysis and shape forming algorithms. This article reviews the results of a novel change detection methodology as a first step for updating NTDB in the Survey of Israel.

  11. [Update on celiac disease].

    PubMed

    Moscoso J, Felipe; Quera P, Rodrigo

    2016-02-01

    The prevalence of Celiac disease in the general population is approximately 1% and remains undiagnosed in a significant proportion of individuals. Its clinical presentation includes the classical malabsorption syndrome, unspecific and extra-intestinal manifestations, and silent celiac disease. The serologic diagnosis has an elevated sensitivity and specificity and, at least in adult population, it must be confirmed by biopsy in every case. Diagnosis in subjects already on gluten free diet includes HLA typing and gluten challenge with posterior serologic and histologic evaluation. The core of the treatment is the gluten free diet, which must be supervised by an expert nutritionist. Monitoring must be performed with serology beginning at 3-6 months, and with histology two years after the diagnosis, unless the clinical response is poor. Poor disease control is associated with complications such as lymphoma and small bowel adenocarcinoma. In the future, it is likely that new pharmacologic therapies will be available for the management of celiac disease. PMID:27092676

  12. Wet storage integrity update

    SciTech Connect

    Bailey, W.J.; Johnson, A.B. Jr.

    1983-09-01

    This report includes information from various studies performed under the Wet Storage Task of the Spent Fuel Integrity Project of the Commercial Spent Fuel Management (CSFM) Program at Pacific Northwest Laboratory. An overview of recent developments in the technology of wet storage of spent water reactor fuel is presented. Licensee Event Reports pertaining to spent fuel pools and the associated performance of spent fuel and storage components during wet storage are discussed. The current status of fuel that was examined under the CSFM Program is described. Assessments of the effect of boric acid in spent fuel pool water on the corrosion and stress corrosion cracking of stainless steel and the stress corrosion cracking of stainless steel piping containing stagnant water at spent fuel pools are discussed. A list of pertinent publications is included. 84 references, 21 figures, 11 tables.

  13. Space Shuttle development update

    NASA Technical Reports Server (NTRS)

    Brand, V.

    1984-01-01

    The development efforts, since the STS-4 flight, in the Space Shuttle (SS) program are presented. The SS improvements introduced in the last two years include lower-weight loads, communication through the Tracking and Data Relay Satellite, expanded extravehicular activity capability, a maneuvering backpack and the manipulator foot restraint, the improvements in thermal projection system, the 'optional terminal area management targeting' guidance software, a rendezvous system with radar and star tracker sensors, and improved on-orbit living conditions. The flight demonstrations include advanced launch techniques (e.g., night launch and direct insertion to orbit); the on-orbit demonstrations; and added entry and launching capabilities. The entry aerodynamic analysis and entry flight control fine tuning are described. Reusability, improved ascent performance, intact abort and landing flexibility, rollout control, and 'smart speedbrakes' are among the many improvements planned for the future.

  14. Geothermal drilling technology update

    SciTech Connect

    Glowka, D.A.

    1997-04-01

    Sandia National Laboratories conducts a comprehensive geothermal drilling research program for the US Department of Energy, Office of Geothermal Technologies. The program currently includes seven areas: lost circulation technology, hard-rock drill bit technology, high-temperature instrumentation, wireless data telemetry, slimhole drilling technology, Geothermal Drilling Organization (GDO) projects, and drilling systems studies. This paper describes the current status of the projects under way in each of these program areas.

  15. Update on INSIGHTS Development

    SciTech Connect

    Not Listed; Eric Burgett

    2011-09-01

    INSIGHTS is a transformational separate effects testing capability to perform in situ irradiation studies and characterization of the microscale behavior of nuclear fuel materials under a wide variety of in-pile conditions. Separate effects testing including growth, irradiation, and monitoring of these materials, and encompasses the full science based approach for fuels development from the nanoscale to the mesoscale behavior of the sample material and other defects driven by the modeling and simulation efforts of INL.

  16. Insightful Imagery is Related to Working Memory Updating

    PubMed Central

    Nęcka, Edward; Żak, Piotr; Gruszka, Aleksandra

    2016-01-01

    Available body of evidence concerning the relationship between insight problem solving and working memory (WM) is ambiguous. Several authors propose that restructuring of the problem representation requires controlled search processes, which needs planning and involvement of WM. Other researchers suggest that the restructuring is achieved through the automatic spread of activation in long-term memory, assigning a limited role to WM capacity. In the present study we examined the correlations between insight problem solving performance and measures of WM updating function (n-back task), including general intelligence (as measured by Raven’s Advanced Progressive Matrices). The results revealed that updating function shared up to 30% of variance with the insight problem task performance, even when the influence of general mental ability was controlled for. These results suggest that insight problem solving is constrained by individual ability to update the content of WM. PMID:26973549

  17. Insightful Imagery is Related to Working Memory Updating.

    PubMed

    Nęcka, Edward; Żak, Piotr; Gruszka, Aleksandra

    2016-01-01

    Available body of evidence concerning the relationship between insight problem solving and working memory (WM) is ambiguous. Several authors propose that restructuring of the problem representation requires controlled search processes, which needs planning and involvement of WM. Other researchers suggest that the restructuring is achieved through the automatic spread of activation in long-term memory, assigning a limited role to WM capacity. In the present study we examined the correlations between insight problem solving performance and measures of WM updating function (n-back task), including general intelligence (as measured by Raven's Advanced Progressive Matrices). The results revealed that updating function shared up to 30% of variance with the insight problem task performance, even when the influence of general mental ability was controlled for. These results suggest that insight problem solving is constrained by individual ability to update the content of WM. PMID:26973549

  18. Tetrameranthus (Annonaceae) revisited including a new species

    PubMed Central

    Westra, Lubbert Y.T.; Maas, Paul J. M.

    2012-01-01

    Abstract The taxonomic revision of the infrequently collected genus Tetrameranthus by Westra (1985) is updated. A new species is described from French Guiana and Amapá, Brazil, increasing the number of species in this genus to seven. PMID:22645410

  19. 42 CFR 495.340 - As-needed HIT PAPD update and as-needed HIT IAPD update requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... update or a HIT IAPD no later than 60 days after the occurrence of project changes including but not... document or the HIT implementation advance planning document. (d) A change in implementation concept or a change to the scope of the project. (e) A change to the approved cost allocation methodology....

  20. Rabies: 2015 Update.

    PubMed

    Burnett, Mark W

    2015-01-01

    Rabies is an almost universally fatal viral disease transmitted to humans primarily by bites and scratches from infected animals, and less commonly through other routes, including transplantation of infected organs, exposure to infected neural tissue, and possibly through airborne and aerosolized routes. This disease is endemic to all continents worldwide except Antarctica, and only a few islands elsewhere can be considered "rabies free." Special Operations Forces medical providers should be aware of this disease. Prevention and recognition of risk are key due to its extreme lethality. PMID:26360364

  1. Westinghouse filter update

    SciTech Connect

    Bruck, G.J.; Smeltzer, E.E.; Newby, R.A.; Bachovchin, D.M.

    1993-06-01

    The Department of Energy, Morgantown Energy Technology Center (DOE/METC), with Westinghouse are developing high temperature particulate filters for application in integrated, coal gasification combined cycle (IGCC) and pressurized fluidized bed combustion (PFBC) power generation systems. Development of these IGCC and PFBC advanced power cycles using subpilot and pilot scale facilities include the integrated operation of a high temperature particulate filter. This testing provides the basis for evaluating filter design, performance and operation characteristics in the actual process gas environment. This operating data is essential for the specification of components and materials and successful scaleup of the filter systems for demonstration and commercial application.

  2. [Microscopic colitis: update 2014].

    PubMed

    Burgmann, Konstantin; Fraga, Montserrat; Schoepfer, Alain M; Yun, Pu

    2014-09-01

    Microscopic colitis, which includes lymphocytic colitis and collagenous colitis, represents a frequent cause of chronic watery diarrhea especially in the elderly population. Several medications, such as nonsteroidal antiinflammatory drugs, proton pump inhibitors or antidepressants, as well as cigarette smoking have been recognized as risk factors for microscopic colitis. The diagnosis of microscopic colitis is based on a macroscopically normal ileo-colonoscopy and several biopsies from the entire colon, which demonstrate the pathognomonic histopathologic findings. Therapy is mainly based on the use of budesonide. Other medications, such as mesalazine, cholestyramine and bismuth, have been evaluated as well but the evidence is less solid. PMID:25276996

  3. Regional update: Cambodia.

    PubMed

    Deva, M P; D'Souza, R; Sundram, S

    2009-10-01

    Cambodia is a developing south-east Asian country located in the fertile Mekong delta. Its recent past has been complicated by European colonialism and internal conflict. Health including mental health services are limited and sparse in regional and rural areas. Very constrained public mental health facilities and services are hampered by a shortage of a skilled workforce and insufficient training programs. The recent formation of the Mental Health Association of Cambodia promises to be a positive step forward in promoting mental health throughout the country. PMID:23051055

  4. Updated NGNP Fuel Acquisition Strategy

    SciTech Connect

    David Petti; Tim Abram; Richard Hobbins; Jim Kendall

    2010-12-01

    A Next Generation Nuclear Plant (NGNP) fuel acquisition strategy was first established in 2007. In that report, a detailed technical assessment of potential fuel vendors for the first core of NGNP was conducted by an independent group of international experts based on input from the three major reactor vendor teams. Part of the assessment included an evaluation of the credibility of each option, along with a cost and schedule to implement each strategy compared with the schedule and throughput needs of the NGNP project. While credible options were identified based on the conditions in place at the time, many changes in the assumptions underlying the strategy and in externalities that have occurred in the interim requiring that the options be re-evaluated. This document presents an update to that strategy based on current capabilities for fuel fabrication as well as fuel performance and qualification testing worldwide. In light of the recent Pebble Bed Modular Reactor (PBMR) project closure, the Advanced Gas Reactor (AGR) fuel development and qualification program needs to support both pebble and prismatic options under the NGNP project. A number of assumptions were established that formed a context for the evaluation. Of these, the most important are: • Based on logistics associated with the on-going engineering design activities, vendor teams would start preliminary design in October 2012 and complete in May 2014. A decision on reactor type will be made following preliminary design, with the decision process assumed to be completed in January 2015. Thus, no fuel decision (pebble or prismatic) will be made in the near term. • Activities necessary for both pebble and prismatic fuel qualification will be conducted in parallel until a fuel form selection is made. As such, process development, fuel fabrication, irradiation, and testing for pebble and prismatic options should not negatively influence each other during the period prior to a decision on reactor type

  5. Literature searches on Ayurveda: An update

    PubMed Central

    Aggithaya, Madhur G.; Narahari, Saravu R.

    2015-01-01

    Introduction: The journals that publish on Ayurveda are increasingly indexed by popular medical databases in recent years. However, many Eastern journals are not indexed biomedical journal databases such as PubMed. Literature searches for Ayurveda continue to be challenging due to the nonavailability of active, unbiased dedicated databases for Ayurvedic literature. In 2010, authors identified 46 databases that can be used for systematic search of Ayurvedic papers and theses. This update reviewed our previous recommendation and identified current and relevant databases. Aims: To update on Ayurveda literature search and strategy to retrieve maximum publications. Methods: Author used psoriasis as an example to search previously listed databases and identify new. The population, intervention, control, and outcome table included keywords related to psoriasis and Ayurvedic terminologies for skin diseases. Current citation update status, search results, and search options of previous databases were assessed. Eight search strategies were developed. Hundred and five journals, both biomedical and Ayurveda, which publish on Ayurveda, were identified. Variability in databases was explored to identify bias in journal citation. Results: Five among 46 databases are now relevant – AYUSH research portal, Annotated Bibliography of Indian Medicine, Digital Helpline for Ayurveda Research Articles (DHARA), PubMed, and Directory of Open Access Journals. Search options in these databases are not uniform, and only PubMed allows complex search strategy. “The Researches in Ayurveda” and “Ayurvedic Research Database” (ARD) are important grey resources for hand searching. About 44/105 (41.5%) journals publishing Ayurvedic studies are not indexed in any database. Only 11/105 (10.4%) exclusive Ayurveda journals are indexed in PubMed. Conclusion: AYUSH research portal and DHARA are two major portals after 2010. It is mandatory to search PubMed and four other databases because all five

  6. JPSS CGS Tools For Rapid Algorithm Updates

    NASA Astrophysics Data System (ADS)

    Smith, D. C.; Grant, K. D.

    2011-12-01

    The National Oceanic and Atmospheric Administration (NOAA) and National Aeronautics and Space Administration (NASA) are jointly acquiring the next-generation civilian weather and environmental satellite system: the Joint Polar Satellite System (JPSS). JPSS will contribute the afternoon orbit component and ground processing system of the restructured National Polar-orbiting Operational Environmental Satellite System (NPOESS). As such, JPSS replaces the current Polar-orbiting Operational Environmental Satellites (POES) managed by NOAA and the ground processing component of both POES and the Defense Meteorological Satellite Program (DMSP) replacement known as the Defense Weather Satellite System (DWSS), managed by the Department of Defense (DoD). The JPSS satellites will carry a suite of sensors designed to collect meteorological, oceanographic, climatological, and solar-geophysical observations of the earth, atmosphere, and space. The ground processing system for JPSS is known as the JPSS Common Ground System (JPSS CGS), and consists of a Command, Control, and Communications Segment (C3S) and the Interface Data Processing Segment (IDPS). Both are developed by Raytheon Intelligence and Information Systems (IIS). The Interface Data Processing Segment will process NPOESS Preparatory Project, Joint Polar Satellite System and Defense Weather Satellite System satellite data to provide environmental data products to NOAA and DoD processing centers operated by the United States government. Under NPOESS, Northrop Grumman Aerospace Systems Algorithms and Data Products (A&DP) organization was responsible for the algorithms that produce the EDRs, including their quality aspects. For JPSS, that responsibility has transferred to NOAA's Center for Satellite Applications & Research (STAR). As the Calibration and Validation (Cal/Val) activities move forward following both the NPP launch and subsequent JPSS and DWSS launches, rapid algorithm updates may be required. Raytheon and

  7. Complete Edentulism and Comorbid Diseases: An Update.

    PubMed

    Felton, David A

    2016-01-01

    The relationship between complete edentulism, which is the terminal outcome of a multifactorial oral disease process and other comorbid diseases, was first reported in 2009. Although the relationship between edentulism and a multitude of systemic diseases was reported, none of the publications studied could determine causality of tooth loss on the incidence of any comorbid disease. Since that publication, there has been a renewed interest in this relationship, and a plethora of new articles have been published. This article will provide an update on articles published since 2008 on the relationship between edentulism and comorbid diseases, and will include the relationship between complete edentulism and such comorbid conditions as malnutrition, obesity, cardiovascular disease, rheumatoid arthritis, pulmonary diseases (including chronic obstructive pulmonary disease), cancer, and even mortality. PMID:26371954

  8. INHERITED NEUROPATHIES: CLINICAL OVERVIEW AND UPDATE

    PubMed Central

    KLEIN, CHRISTOPHER J.; DUAN, XIAOHUI; SHY, MICHAEL E.

    2014-01-01

    Inherited neuropathy is a group of common neurologic disorders with heterogeneous clinical presentations and genetic causes. Detailed neuromuscular evaluations, including nerve conduction studies, laboratory testing, and histopathologic examination, can assist in identification of the inherited component beyond family history. Genetic testing increasingly enables definitive diagnosis of specific inherited neuropathies. Diagnosis, however, is often complex, and neurologic disability may have both genetic and acquired components in individual patients. The decision of which genetic test to order or whether to order genetic tests is often complicated, and the strategies to maximize the value of testing are evolving. Apart from rare inherited metabolic neuropathies, treatment approaches remain largely supportive. We provide a clinical update of the various types of inherited neuropathies, their differential diagnoses, and distinguishing clinical features (where available). A framework is provided for clinical evaluations, including the inheritance assessment, electrophysiologic examinations, and specific genetic tests. PMID:23801417

  9. Preclinical Rheumatoid Arthritis (Autoantibodies): An Updated Review

    PubMed Central

    Deane, Kevin D.

    2014-01-01

    Multiple studies demonstrate that there is a period of development of rheumatoid arthritis (RA) during which there are elevations of disease-related biomarkers, including autoantibodies, in the absence of and prior to the development of RA; this period can be termed ‘preclinical RA’. These ‘preclinical’ autoantibodies including rheumatoid factor and antibodies to citrullinated protein antigens, and more recent studies have also identified a wider variety of autoantibodies and a wide range of inflammatory biomarkers. These findings in conjunction with established and emerging data about genetic and environmental risk factors for RA support a model of disease development where certain factors lead to an initial triggering of RA-related autoimmunity that expands over time to the point where symptomatic arthritis classifiable as RA develops. Herein will be reviewed updates in the field, as well as a discussion of current limitations of our understanding of preclinical RA, and potential future directions for study. PMID:24643396

  10. Heidrun concrete TLP: Update

    SciTech Connect

    Munkejord, T.

    1995-10-01

    This paper gives a summary of the Heidrun substructure including tethers and foundations. The focus will although be on the concrete substructure. The Heidrun Field is located in 345 m water depth in the northern part of the Haltenbanken area, approximately 100N miles from the west coast of mid-Norway. The field is developed by means of a concrete Tension Leg Platform (TLP) by Conoco Norway Inc. The TLP will be moored by 16 steel tethers, arranged in groups of four per corner, which secure the substructure (hull) to the concrete foundations. A general view of the TLP is shown. The Heidrun TLP will be the northern most located platform in the North Sea when installed at Haltenbanken in 1995. Norwegian Contractors a.s (NC) is undertaking the Engineering, Procurement, Construction and Installation (EPCI) contract for the Heidrun TLP substructure. This comprises the complete delivery of the hull with two module support beams (MSB), including all mechanical outfitting. Furthermore, NC will perform all marine operations related to the substructure. For the concrete foundations NC has performed the detailed engineering work and has been responsible for the two to field and installation of the foundations.

  11. Pediatric psoriasis: an update

    PubMed Central

    Silverberg, Nanette B

    2009-01-01

    Pediatric psoriasis consists broadly of 3 age groups of psoriatic patients: infantile psoriasis, a self-limited disease of infancy, psoriasis with early onset, and pediatric psoriasis with psoriatic arthritis. About one-quarter of psoriasis cases begin before the age of 18 years. A variety of clinical psoriasis types are seen in childhood, including plaque-type, guttate, erythrodermic, napkin, and nail-based disease. Like all forms of auto-immunity, susceptibility is likely genetic, but environmental triggers are required to initiate disease activity. The most common trigger of childhood is an upper respiratory tract infection. Once disease has occurred, treatment is determined based on severity and presence of joint involvement. Topical therapies, including corticosteroids and calcipotriene, are the therapies of choice in the initial care of pediatric patients. Ultraviolet light, acitretin and cyclosporine can clear skin symptoms, while methotrexate and etanercept can clear both cutaneous and joint disease. Concern for psychological development is required when choosing psoriatic therapies. This article reviews current concepts in pediatric psoriasis and a rational approach to therapeutics. PMID:19898649

  12. STATISTICAL BASED NON-LINEAR MODEL UPDATING USING FEATURE EXTRACTION

    SciTech Connect

    Schultz, J.F.; Hemez, F.M.

    2000-10-01

    This research presents a new method to improve analytical model fidelity for non-linear systems. The approach investigates several mechanisms to assist the analyst in updating an analytical model based on experimental data and statistical analysis of parameter effects. The first is a new approach at data reduction called feature extraction. This is an expansion of the update metrics to include specific phenomena or character of the response that is critical to model application. This is an extension of the classical linear updating paradigm of utilizing the eigen-parameters or FRFs to include such devices as peak acceleration, time of arrival or standard deviation of model error. The next expansion of the updating process is the inclusion of statistical based parameter analysis to quantify the effects of uncertain or significant effect parameters in the construction of a meta-model. This provides indicators of the statistical variation associated with parameters as well as confidence intervals on the coefficients of the resulting meta-model, Also included in this method is the investigation of linear parameter effect screening using a partial factorial variable array for simulation. This is intended to aid the analyst in eliminating from the investigation the parameters that do not have a significant variation effect on the feature metric, Finally an investigation of the model to replicate the measured response variation is examined.

  13. The primordial helium abundance from updated emissivities

    SciTech Connect

    Aver, Erik; Olive, Keith A.; Skillman, Evan D.; Porter, R.L. E-mail: olive@umn.edu E-mail: skillman@astro.umn.edu

    2013-11-01

    Observations of metal-poor extragalactic H II regions allow the determination of the primordial helium abundance, Y{sub p}. The He I emissivities are the foundation of the model of the H II region's emission. Porter, Ferland, Storey, and Detisch (2012) have recently published updated He I emissivities based on improved photoionization cross-sections. We incorporate these new atomic data and update our recent Markov Chain Monte Carlo analysis of the dataset published by Izotov, Thuan, and Stasi'nska (2007). As before, cuts are made to promote quality and reliability, and only solutions which fit the data within 95% confidence level are used to determine the primordial He abundance. The previously qualifying dataset is almost entirely retained and with strong concordance between the physical parameters. Overall, an upward bias from the new emissivities leads to a decrease in Y{sub p}. In addition, we find a general trend to larger uncertainties in individual objects (due to changes in the emissivities) and an increased variance (due to additional objects included). From a regression to zero metallicity, we determine Y{sub p} = 0.2465 ± 0.0097, in good agreement with the BBN result, Y{sub p} = 0.2485 ± 0.0002, based on the Planck determination of the baryon density. In the future, a better understanding of why a large fraction of spectra are not well fit by the model will be crucial to achieving an increase in the precision of the primordial helium abundance determination.

  14. Update on melatonin receptors: IUPHAR Review 20.

    PubMed

    Jockers, Ralf; Delagrange, Philippe; Dubocovich, Margarita L; Markus, Regina P; Renault, Nicolas; Tosini, Gianluca; Cecon, Erika; Zlotos, Darius P

    2016-09-01

    Melatonin receptors are seven transmembrane-spanning proteins belonging to the GPCR superfamily. In mammals, two melatonin receptor subtypes exist - MT1 and MT2 - encoded by the MTNR1A and MTNR1B genes respectively. The current review provides an update on melatonin receptors by the corresponding subcommittee of the International Union of Basic and Clinical Pharmacology. We will highlight recent developments of melatonin receptor ligands, including radioligands, and give an update on the latest phenotyping results of melatonin receptor knockout mice. The current status and perspectives of the structure of melatonin receptor will be summarized. The physiological importance of melatonin receptor dimers and biologically important and type 2 diabetes-associated genetic variants of melatonin receptors will be discussed. The role of melatonin receptors in physiology and disease will be further exemplified by their functions in the immune system and the CNS. Finally, antioxidant and free radical scavenger properties of melatonin and its relation to melatonin receptors will be critically addressed. PMID:27314810

  15. A taxonomy update for the family Polyomaviridae.

    PubMed

    Calvignac-Spencer, Sébastien; Feltkamp, Mariet C W; Daugherty, Matthew D; Moens, Ugo; Ramqvist, Torbjörn; Johne, Reimar; Ehlers, Bernhard

    2016-06-01

    Many distinct polyomaviruses infecting a variety of vertebrate hosts have recently been discovered, and their complete genome sequence could often be determined. To accommodate this fast-growing diversity, the International Committee on Taxonomy of Viruses (ICTV) Polyomaviridae Study Group designed a host- and sequence-based rationale for an updated taxonomy of the family Polyomaviridae. Applying this resulted in numerous recommendations of taxonomical revisions, which were accepted by the Executive Committee of the ICTV in December 2015. New criteria for definition and creation of polyomavirus species were established that were based on the observed distance between large T antigen coding sequences. Four genera (Alpha-, Beta, Gamma- and Deltapolyomavirus) were delineated that together include 73 species. Species naming was made as systematic as possible - most species names now consist of the binomial name of the host species followed by polyomavirus and a number reflecting the order of discovery. It is hoped that this important update of the family taxonomy will serve as a stable basis for future taxonomical developments. PMID:26923930

  16. SP-100 reactor and shield design update

    NASA Astrophysics Data System (ADS)

    Deane, Nelson A.; Stewart, Samuel L.; Marcille, Thomas F.; Newkirk, Douglas W.

    1992-01-01

    The SP-100 technical specification for the generic flight system has been updated to eliminate design specific and unnecessarily restrictive requirements. Relaxation of these requirements allows considerably more flexibility to the reactor and shield designer to minimize the mass of the system. Ground Engineering System (GES) Program test results are also beginning to become available to the designer. Some of these test results in combination with the design requirement changes have lead to design changes in 1) the fuel pin to include an aft axial reflector, 2) the reflector control mechanism concept from a hinged to an aft sliding system, 3) the number of safety rods from seven to three, and 4) the use of Be and B4C instead of LiH in the forward neutron field section. These changes have been developed to minimize the mass of the total system. Generic Flight System Design Option/Update Studies are ongoing activities with mass reduction as the primary objective to assure that the Flight System Qualification Program adequately defines and achieves the development needs.

  17. Chitinases: An update

    PubMed Central

    Hamid, Rifat; Khan, Minhaj A.; Ahmad, Mahboob; Ahmad, Malik Mobeen; Abdin, Malik Zainul; Musarrat, Javed; Javed, Saleem

    2013-01-01

    Chitin, the second most abundant polysaccharide in nature after cellulose, is found in the exoskeleton of insects, fungi, yeast, and algae, and in the internal structures of other vertebrates. Chitinases are enzymes that degrade chitin. Chitinases contribute to the generation of carbon and nitrogen in the ecosystem. Chitin and chitinolytic enzymes are gaining importance for their biotechnological applications, especially the chitinases exploited in agriculture fields to control pathogens. Chitinases have a use in human health care, especially in human diseases like asthma. Chitinases have wide-ranging applications including the preparation of pharmaceutically important chitooligosaccharides and N-acetyl D glucosamine, preparation of single-cell protein, isolation of protoplasts from fungi and yeast, control of pathogenic fungi, treatment of chitinous waste, mosquito control and morphogenesis, etc. In this review, the various types of chitinases and the chitinases found in different organisms such as bacteria, plants, fungi, and mammals are discussed. PMID:23559820

  18. [Update on fecal incontinence].

    PubMed

    Buhmann, Helena; Nocito, Antonio

    2014-10-29

    Fecal incontinence is defined as an accidental loss of stool or the inability to control defecation. There are three subtypes of fecal incontinence: passive incontinence, urge incontinence and soiling. About 8% of the adult population suffer from fecal incontinence, but only 1/3 consults a doctor. Beside the individual handicap, fecal incontinence has a huge socio-economic impact. Causes of fecal incontinence are changes in the quantity or quality of the stool and structural or functional disorders. Diagnostics encompass the medical history, clinical examination including the digital rectal examination, imaging (particularly endoanal ultrasound) as well as functional diagnostics (anal manometry and defecography). Nowadays, the most promising conservative treatment option consists of loperamide and biofeedback therapy. The most successful invasive method is the sacral neuromodulation. PMID:25351694

  19. Renal Ablation Update

    PubMed Central

    Khiatani, Vishal; Dixon, Robert G.

    2014-01-01

    Thermal ablative technologies have evolved considerably in the recent past and are now an important component of current clinical guidelines for the treatment of small renal masses. Both radiofrequency ablation and cryoablation have intermediate-term oncologic control that rivals surgical options, with favorable complication profiles. Studies comparing cryoablation and radiofrequency ablation show no significant difference in oncologic control or complication profile between the two modalities. Early data from small series with microwave ablation have shown similar promising results. Newer technologies including irreversible electroporation and high-intensity–focused ultrasound have theoretical advantages, but will require further research before becoming a routine part of the ablation armamentarium. The purpose of this review article is to discuss the current ablative technologies available, briefly review their mechanisms of action, discuss technical aspects of each, and provide current data supporting their use. PMID:25049445

  20. NIF capsule design update

    SciTech Connect

    Dittrich, T.R.; Haan, S.W.; Pollaine, S.; Burnham, A.K.; Strobel, G.L.

    1996-10-01

    We describe several ignition capsule designs, for use in the National Ignition Facility. We will compare these designs for ablator efficiency, ignition margin, implosion and stability performance. This study includes capsule designs driven by x-ray drive profiles with both 300 eV and 250 eV peak temperatures. All of the 300 eV designs are tuned to implode the DT fuel in a nearly identical manner. Capsule designs consist of an ablator material (CH with Br dopant; Be with Cu dopant; and B{sub 4}C) encasing a layer of solid DT. The dopants alter material opacities sufficiently to (1) shield the DT fuel from preheat effects; and (2) develop an ablation front density profile favorable to implosion stability. B{sub 4}C has sufficient opacity at 300 eV that a dopant is not necessary. Issues relating to material properties and fabrication will be described.

  1. Update on Islet Transplantation

    PubMed Central

    McCall, Michael; James Shapiro, A.M.

    2012-01-01

    Clinical islet transplantation has progressed considerably over the past 12 years, and >750 patients with type 1 diabetes have received islet transplants internationally over this time. Many countries are beginning to accept the transition from research to accepted and funded clinical care, especially for patients with brittle control that cannot be stabilized by more conventional means. Major challenges remain, including the need for more than one donor, and the requirement for potent, chronic immunosuppression. Combining immunological tolerance both to allo- and autoantigens, and a limitless expandable source of stem cell- or xenograft-derived insulin-secreting cells represent remaining hurdles in moving this effective treatment to a potential cure for all those with type 1 or 2 diabetes. PMID:22762022

  2. Update on food allergy.

    PubMed

    Carrard, A; Rizzuti, D; Sokollik, C

    2015-12-01

    Food allergies are a global health issue with increasing prevalence. Allergic reactions can range from mild local symptoms to severe anaphylactic reactions. Significant progress has been made in diagnostic tools such as component-resolved diagnostics and its impact on risk stratification as well as in therapeutic approaches including biologicals. However, a cure for food allergy has not yet been achieved and patients and their families are forced to alter eating habits and social engagements, impacting their quality of life. New technologies and improved in vitro and in vivo models will advance our knowledge of the pathogenesis of food allergies and multicenter-multinational cohort studies will elucidate interactions between genetic background, lifestyle, and environmental factors. This review focuses on new insights and developments in the field of food allergy and summarizes recently published articles. PMID:26443043

  3. Female athlete triad update.

    PubMed

    Beals, Katherine A; Meyer, Nanna L

    2007-01-01

    The passage of Title IX legislation in 1972 provided enormous opportunities for women to reap the benefits of sports participation. For most female athletes, sports participation is a positive experience, providing improved physical fitness, enhanced self-esteem, and better physical and mental health. Nonetheless, for a few female athletes, the desire for athletic success combined with the pressure to achieve a prescribed body weight may lead to the development of a triad of medical disorders including disordered eating, menstrual dysfunction, and low bone mineral density (BMD)--known collectively as the female athlete triad. Alone or in combination, the disorders of the triad can have a negative impact on health and impair athletic performance. PMID:17241915

  4. Renal ablation update.

    PubMed

    Khiatani, Vishal; Dixon, Robert G

    2014-06-01

    Thermal ablative technologies have evolved considerably in the recent past and are now an important component of current clinical guidelines for the treatment of small renal masses. Both radiofrequency ablation and cryoablation have intermediate-term oncologic control that rivals surgical options, with favorable complication profiles. Studies comparing cryoablation and radiofrequency ablation show no significant difference in oncologic control or complication profile between the two modalities. Early data from small series with microwave ablation have shown similar promising results. Newer technologies including irreversible electroporation and high-intensity-focused ultrasound have theoretical advantages, but will require further research before becoming a routine part of the ablation armamentarium. The purpose of this review article is to discuss the current ablative technologies available, briefly review their mechanisms of action, discuss technical aspects of each, and provide current data supporting their use. PMID:25049445

  5. Updating the Wnt pathways

    PubMed Central

    Yu, Jia; Virshup, David M.

    2014-01-01

    In the three decades since the discovery of the Wnt1 proto-oncogene in virus-induced mouse mammary tumours, our understanding of the signalling pathways that are regulated by the Wnt proteins has progressively expanded. Wnts are involved in an complex signalling network that governs multiple biological processes and cross-talk with multiple additional signalling cascades, including the Notch, FGF (fibroblast growth factor), SHH (Sonic hedgehog), EGF (epidermal growth factor) and Hippo pathways. The Wnt signalling pathway also illustrates the link between abnormal regulation of the developmental processes and disease manifestation. Here we provide an overview of Wnt-regulated signalling cascades and highlight recent advances. We focus on new findings regarding the dedicated Wnt production and secretion pathway with potential therapeutic targets that might be beneficial for patients with Wnt-related diseases. PMID:25208913

  6. Advanced Virgo: AN Update

    NASA Astrophysics Data System (ADS)

    Fafone, Viviana

    2015-01-01

    Significant progress has been made in recent years on the development of gravitational wave detectors. Several km-scale interferometers have already operated at interesting sensitivity levels. In particular, the interferometric detector for gravitational waves Virgo completed its fourth science run in August 2011, when the upgrade toward the second-generation detector Advanced Virgo started. This major upgrade is planned to be completed by 2015. The expected final sensitivity of Advanced Virgo is about ten times better than the sensitivity reached by its predecessor. Many of the components of the detector will be changed to meet this goal, including new core optics, a more powerful laser, an improved vacuum system, the implementation of the signal-recycling technique. In this paper the description of the project and the expected schedule are presented.

  7. Carney Complex: an update

    PubMed Central

    Correa, Ricardo; Salpea, Paraskevi; Stratakis, Constantine

    2015-01-01

    Carney Complex (CNC) is a rare autosomal dominant syndrome, characterized by pigmented lesions of the skin and mucosa, cardiac, cutaneous and other myxomas, and multiple endocrine tumors. The disease is caused by inactivating mutations or large deletions of the PRKAR1A gene located at 17q22–24 coding for the regulatory subunit type I alpha of protein kinase A (PKA) gene. Most recently, components of the complex have been associated with defects of other PKA subunits, such as the catalytic subunits PRKACA (adrenal hyperplasia) and PRKACB (pigmented spots, myxomas, pituitary adenomas). In this report, we review CNC, its clinical features, diagnosis, treatment, and molecular etiology including PRKAR1A mutations and the newest on PRKACA and PRKACB defects especially as they pertain to adrenal tumors and Cushing’s syndrome. PMID:26130139

  8. Carney complex: an update.

    PubMed

    Correa, Ricardo; Salpea, Paraskevi; Stratakis, Constantine A

    2015-10-01

    Carney complex (CNC) is a rare autosomal dominant syndrome, characterized by pigmented lesions of the skin and mucosa, cardiac, cutaneous and other myxomas and multiple endocrine tumors. The disease is caused by inactivating mutations or large deletions of the PRKAR1A gene located at 17q22-24 coding for the regulatory subunit type I alpha of protein kinase A (PKA) gene. Most recently, components of the complex have been associated with defects of other PKA subunits, such as the catalytic subunits PRKACA (adrenal hyperplasia) and PRKACB (pigmented spots, myxomas, pituitary adenomas). In this report, we review CNC, its clinical features, diagnosis, treatment and molecular etiology, including PRKAR1A mutations and the newest on PRKACA and PRKACB defects especially as they pertain to adrenal tumors and Cushing's syndrome. PMID:26130139

  9. Update on zinc biology.

    PubMed

    Solomons, Noel W

    2013-01-01

    Zinc has become a prominent nutrient of clinical and public health interest in the new millennium. Functions and actions for zinc emerge as increasingly ubiquitous in mammalian anatomy, physiology and metabolism. There is undoubtedly an underpinning in fundamental biology for all of the aspects of zinc in human health (clinical and epidemiological) in pediatric and public health practice. Unfortunately, basic science research may not have achieved a full understanding as yet. As a complement to the applied themes in the companion articles, a selection of recent advances in the domains homeostatic regulation and transport of zinc is presented; they are integrated, in turn, with findings on genetic expression, intracellular signaling, immunity and host defense, and bone growth. The elements include ionic zinc, zinc transporters, metallothioneins, zinc metalloenzymes and zinc finger proteins. In emerging basic research, we find some plausible mechanistic explanations for delayed linear growth with zinc deficiency and increased infectious disease resistance with zinc supplementation. PMID:23689109

  10. Update on cutaneous calciphylaxis.

    PubMed

    Wollina, Uwe

    2013-03-01

    Calciphylaxis is a devastating disorder with a mortality rate of 80% due to sepsis and organ failure. Hallmarks of this rare disease are arteriolar media calcification, thrombotic cutaneous ischemia, and necrotic ulcerations. Different mechanisms of vascular calcification can lead to calciphylaxis. Early diagnosis by deep cutaneous ulcer biopsy is most important for prognosis. Here, dermatologists play a significant role although treatment usually needs an interdisciplinary approach. Surgical procedures had been the cornerstone of treatment in the past including parathyroidectomy, but recently new medical treatments emerged aiming to normalize disturbances of minerals to reduce the serum concentration of sodium phosphate and to prevent precipitation and calcification. Multimodal therapy is warranted but only aggressive surgical debridement of cutaneous ulcers has shown significant outcome improvement. PMID:23716795

  11. Update on Cutaneous Calciphylaxis

    PubMed Central

    Wollina, Uwe

    2013-01-01

    Calciphylaxis is a devastating disorder with a mortality rate of 80% due to sepsis and organ failure. Hallmarks of this rare disease are arteriolar media calcification, thrombotic cutaneous ischemia, and necrotic ulcerations. Different mechanisms of vascular calcification can lead to calciphylaxis. Early diagnosis by deep cutaneous ulcer biopsy is most important for prognosis. Here, dermatologists play a significant role although treatment usually needs an interdisciplinary approach. Surgical procedures had been the cornerstone of treatment in the past including parathyroidectomy, but recently new medical treatments emerged aiming to normalize disturbances of minerals to reduce the serum concentration of sodium phosphate and to prevent precipitation and calcification. Multimodal therapy is warranted but only aggressive surgical debridement of cutaneous ulcers has shown significant outcome improvement. PMID:23716795

  12. Update on obesity.

    PubMed

    Bessesen, Daniel H

    2008-06-01

    Endocrinologists have unique skills in evaluating and caring for patients with metabolic diseases. As such, they have a special role to play within the organizations in which they work as leaders in the approach to managing obese patients. Recent epidemiological data demonstrate that the prevalence of obesity is beginning to plateau. However, the rate of severe obesity in adults and the prevalence of overweight among children continue to grow, suggesting that in the future there will be an increasing burden of obesity-related illnesses. A number of recent studies have identified a number of novel mechanisms that predispose to obesity including several newly identified genes, the role of intestinal microflora, and even social networks. The selection of treatment for obese patients remains a complex issue. Recent studies demonstrate that a range of dietary approaches including the Atkins diet can provide modest weight loss, although the key feature appears to be adherence in the dietary strategy. High levels of physical activity appear to be necessary to maintain a reduced state, although modest increases in activity improve fitness. Although the new understanding of biology of weight regulation has provided a wide range of potential drug targets, available pharmacotherapy options remain limited although a number of potential targets show promise. Recent data provides the most enthusiasm for surgical treatment of obesity. Several recent studies demonstrate a reduction in mortality and dramatic benefits in diabetes in obese patients treated surgically. Questions remain as to the best surgical approach and the cost effectiveness. Research advances in obesity continue to move at a rapid pace and raise hopes for more effective management strategies in the future. PMID:18539769

  13. Stroke prevention: an update.

    PubMed

    Bousser, Marie-Germaine

    2012-03-01

    Stroke is a personal, familial, and social disaster. It is the third cause of death worldwide, the first cause of acquired disability, the second cause of dementia, and its cost is astronomic. The burden of stroke is likely to increase given the aging of the population and the growing incidence of many vascular risk factors. Prevention of stroke includes--as for all other diseases--a "mass approach" aiming at decreasing the risk at the society level and an individual approach, aiming at reducing the risk in a given subject. The mass approach is primarily based on the identification and treatment of vascular risk factors and, if possible, in the implementation of protective factors. These measures are the basis of primary prevention but most of them have now been shown to be also effective in secondary prevention. The individual approach combines a vascular risk factor modification and various treatments addressing the specific subtypes of stroke, such as antiplatelet drugs for the prevention of cerebral infarction in large and small artery diseases of the brain, carotid endarterectomy or stenting for tight carotid artery stenosis, and oral anticoagulants for the prevention of cardiac emboli. There is a growing awareness of the huge evidence-to-practice gap that exists in stroke prevention largely due to socio-economic factors. Recent approaches include low cost intervention packages to reduce blood pressure and cheap "polypills" combining in a single tablet aspirin and several drugs to lower blood pressure and cholesterol. Polypill intake should however not lead to abandon the healthy life-style measures which remain the mainstay of stroke prevention. PMID:22460445

  14. NPOESS Field Terminal Updates

    NASA Astrophysics Data System (ADS)

    Heckmann, G.; Route, G.

    2009-12-01

    The National Oceanic and Atmospheric Administration (NOAA), Department of Defense (DoD), and National Aeronautics and Space Administration (NASA) are jointly acquiring the next-generation weather and environmental satellite system; the National Polar-orbiting Operational Environmental Satellite System (NPOESS). NPOESS replaces the current Polar-orbiting Operational Environmental Satellites (POES) managed by NOAA and the Defense Meteorological Satellite Program (DMSP) managed by the DoD. The NPOESS satellites carry a suite of sensors that collect meteorological, oceanographic, climatological, and solar-geophysical observations of the earth, atmosphere, and space. The ground data processing segment for NPOESS is the Interface Data Processing Segment (IDPS), developed by Raytheon Intelligence and Information Systems. The IDPS processes NPOESS satellite data to provide environmental data products (aka, Environmental Data Records or EDRs) to NOAA and DoD processing centers operated by the United States government. The IDPS will process EDRs beginning with the NPOESS Preparatory Project (NPP) and continuing through the lifetime of the NPOESS system. IDPS also provides the software and requirements for the Field Terminal Segment (FTS). NPOESS provides support to deployed field terminals by providing mission data in the Low Rate and High Rate downlinks (LRD/HRD), mission support data needed to generate EDRs and decryption keys needed to decrypt mission data during Selective data Encryption (SDE). Mission support data consists of globally relevant data, geographically constrained data, and two line element sets. NPOESS provides these mission support data via the Internet accessible Mission Support Data Server and HRD/LRD downlinks. This presentation will illustrate and describe the NPOESS capabilities in support of Field Terminal users. This discussion will include the mission support data available to Field Terminal users, content of the direct broadcast HRD and LRD

  15. Source Update Capture in Information Agents

    NASA Technical Reports Server (NTRS)

    Ashish, Naveen; Kulkarni, Deepak; Wang, Yao

    2003-01-01

    In this paper we present strategies for successfully capturing updates at Web sources. Web-based information agents provide integrated access to autonomous Web sources that can get updated. For many information agent applications we are interested in knowing when a Web source to which the application provides access, has been updated. We may also be interested in capturing all the updates at a Web source over a period of time i.e., detecting the updates and, for each update retrieving and storing the new version of data. Previous work on update and change detection by polling does not adequately address this problem. We present strategies for intelligently polling a Web source for efficiently capturing changes at the source.

  16. Update on azole antifungals.

    PubMed

    Zonios, Dimitrios I; Bennett, John E

    2008-04-01

    This is a comprehensive, clinically oriented review of the four commercially available triazoles: fluconazole, itraconazole, voriconazole, and posaconazole. Emphasis is placed in pharmacology, drug interactions, adverse events, antifungal activity, and the evolving perspective of their clinical use. Key clinical trials are briefly discussed, and specific drug indications summarized. Fluconazole remains a valuable low-cost choice for the treatment of various fungal infections, including candidiasis and cryptococcosis. It has relatively few drug interactions and is safe but lacks activity against filamentous fungi. The use of itraconazole is historically plagued by erratic bioavailability of the oral capsule, improved with the oral solution. Drug interactions are numerous. Itraconazole exhibits significant activity against Aspergillus and the endemic fungi. Voriconazole has revolutionized the treatment of aspergillosis in severely immunocompromised patients, but its use is compromised by complicated pharmacokinetics, notable drug interactions, and relatively significant adverse events. Finally, posaconazole is the last addition to the azole armamentarium with extended antifungal spectrum, significant activity against the zygomycetes, and, apparently, optimal safety profile. Posaconazole has a significant role for the prophylaxis of invasive fungal infections in severely immunocompromised patients. Multiple daily dosing, a need for fatty foods for absorption, and absence of an intravenous formulation restrict its use to selected populations. PMID:18366001

  17. Update on Neonatal Hypoglycemia

    PubMed Central

    Rozance, Paul J.

    2014-01-01

    Purpose of Review Neonatal hypoglycemia is one of the most common biochemical abnormalities encountered in the newborn. However, controversy remains surrounding its definition and management especially in asymptomatic patients. Recent Findings New information has been published that describes the incidence and timing of low glucose concentrations in the groups most at risk for asymptomatic neonatal hypoglycemia. Furthermore, one large prospective study failed to find an association between repetitive low glucose concentrations and poor neurodevelopmental outcomes in preterm infants. But hypoglycemia due to hyperinsulinism, especially genetic causes, continued to be associated with brain injury. New advances were made in the diagnosis and management of hyperinsulinism, including acquired hyperinsulinism in small for gestational age infants and others. Continuous glucose monitoring remains an attractive strategy for future research in this area. Summary The fundamental question of how best to manage asymptomatic newborns with low glucose concentrations remains unanswered. Balancing the risks of over treating newborns with low glucose concentrations who are undergoing a normal transition following birth against the risks of under treating those in whom low glucose concentrations are pathological, dangerous, and/or a harbinger of serious metabolic disease remains a challenge. PMID:24275620

  18. EPA risk management update

    SciTech Connect

    Mentzer, W.P.

    1995-09-01

    The US Environmental Protection Agency (EPA) Clean Air Act (CAA) was passed in 1970 with amendments added in 1970 and 1990. The 1990 amendments require the EPA to develop regulations to prevent or mitigate chemical accidents that could affect the public and the environment. The regulation is the EPA`s Risk Management Programs (RMP) for Chemical Accidental Release Prevention and was published as proposed rule 40 CFR 68. The RMP is similar to OSHA`s Process Safety Management standard which became effective on May 26, 1992. The EPA`s Risk Management Program deals with 77 toxic chemicals, 63 flammable gases and liquids and certain explosives used at 122,000 work sites. The key elements of the RMP include: registration; hazard assessment; prevention program; emergency response; risk management plan; auditing; and enforcement. The Sierra Club sued the EPA to obtain a court-ordered deadline for promulgation of the final RMP rule. The Oct. 1994 court-approved settlement permitted the EPA to issue a supplemental rulemaking notice and set March 29, 1996, as the deadline for the final RMP rule. The supplemental rulemaking notice, issued by the EPA on March 2, 1995, presents preferred approaches to several key issues in the RMP. The presentation will cover the evolution of the EPA-CAAA-RMP, the requirements of the RMP and the significant changes resulting from the supplemental rulemaking.

  19. Liposuction devices: technology update.

    PubMed

    Shridharani, Sachin M; Broyles, Justin M; Matarasso, Alan

    2014-01-01

    Since its introduction by Illouz and others over 30 years ago, suction-assisted lipectomy/liposuction/lipoplasty has evolved tremendously and has developed into one of the most popular procedures in aesthetic plastic surgery. Liposuction is an effective procedure employed to treat localized adipose deposits in patients not suffering from generalized obesity. These accumulations of subcutaneous fat often occur in predictable distributions in both men and women. A cannula connected to a suction-generating source allows for small incisions to be strategically placed and large volumes of fat to be removed. This fat removal leads to improved harmonious balance of a patient's physique and improved body contour. Various surgical techniques are available and have evolved as technology has improved. Current technology for liposuction includes suction-assisted lipectomy, ultrasound-assisted, power-assisted, laser-assisted, and radiofrequency-assisted. The choice of technology and technique often depends on patient characteristics and surgeon preference. The objective of this review is to provide a thorough assessment of current technologies available to plastic surgeons performing liposuction. PMID:25093000

  20. Update on Biomaterials.

    PubMed

    Anderson, Paul A; Giori, Nicholas J; Lavernia, Carlos J; Villa, Jesus M; Greenwald, A Seth

    2016-01-01

    Biomaterials are essential to the use and development of successful treatments for orthopaedic patients. Orthopaedic surgeons need to understand the expected clinical performance and the effects of implants in patients. Recent attempts to improve implant durability have resulted in adverse effects related to biomaterials and their relationship to patients. Examples of these adverse effects in hip arthroplasty include wear and corrosion of metal-on-metal bearings, trunnions, and tapered modular neck junctions. Conversely, polymers and ceramics have shown substantial improvements in durability. Improved implant compositions and manufacturing processes have resulted in ceramic head and acetabular liners with improved material properties and the avoidance of voids, which have, in the past, caused catastrophic fractures. Cross-linking of polyethylene with radiation and doping with antioxidants has substantially increased implant durability and is increasingly being used in joint prostheses other than the hip. Additive manufacturing is potentially a transformative process; it can lead to custom and patient-specific implants and to improvements in material properties, which can be optimized to achieve desired bone responses. Orthopaedic surgeons must understand the material properties and the biologic effects of new or altered biomaterials and manufacturing processes before use. In addition, a clear benefit to the patient must be proven based on superior preclinical results and high-quality clinical investigations before orthopaedic surgeons use new or altered biomaterials. PMID:27049211

  1. Tigecycline: a critical update.

    PubMed

    Shakil, S; Akram, M; Khan, A U

    2008-08-01

    Tigecycline is the first Food and Drug Administration (FDA) approved glycylcycline antibiotic. It has shown remarkable in vitro activity against a wide variety of gram-positive, gram-negative and anaerobic bacteria including many multidrug resistant (MDR) strains. However, it has minimal activity against Pseudomonas aeruginosa and Proteus spp. To date, little resistance to tigecycline has been reported. Clinical trials studying complicated skin and skin-structure infections (cSSSIs) demonstrated that tigecycline has equivalent efficacy and safety compared with the combination of vancomycin and aztreonam. For complicated intra-abdominal infections (cIAIs), tigecycline was found to be as effective as imipenem/cilastatin. Adverse events related to tigecycline therapy, i.e. nausea and vomiting, were tolerable. Currently available data suggest that tigecycline may play an important role in the future as a monotherapy alternative to older broad-spectrum antibiotics, such as advanced generation cephalosporins, carbapenems, fluoroquinolones, piperacillin/tazobactam, and gram-positive directed agents (e.g. daptomycin, linezolid and quinupristin/dalfopristin) for which resistance is being increasingly reported from all parts of the world. PMID:18676218

  2. Studsvik Processing Facility Update

    SciTech Connect

    Mason, J. B.; Oliver, T. W.; Hill, G. M.; Davin, P. F.; Ping, M. R.

    2003-02-25

    Studsvik has completed over four years of operation at its Erwin, TN facility. During this time period Studsvik processed over 3.3 million pounds (1.5 million kgs) of radioactive ion exchange bead resin, powdered filter media, and activated carbon, which comprised a cumulative total activity of 18,852.5 Ci (6.98E+08 MBq). To date, the highest radiation level for an incoming resin container has been 395 R/hr (3.95 Sv/h). The Studsvik Processing Facility (SPF) has the capability to safely and efficiently receive and process a wide variety of solid and liquid Low Level Radioactive Waste (LLRW) streams including: Ion Exchange Resins (IER), activated carbon (charcoal), graphite, oils, solvents, and cleaning solutions with contact radiation levels of up to 400 R/hr (4.0 Sv/h). The licensed and heavily shielded SPF can receive and process liquid and solid LLRWs with high water and/or organic content. This paper provides an overview of the last four years of commercial operations processing radioactive LLRW from commercial nuclear power plants. Process improvements and lessons learned will be discussed.

  3. Liposuction devices: technology update

    PubMed Central

    Shridharani, Sachin M; Broyles, Justin M; Matarasso, Alan

    2014-01-01

    Since its introduction by Illouz and others over 30 years ago, suction-assisted lipectomy/liposuction/lipoplasty has evolved tremendously and has developed into one of the most popular procedures in aesthetic plastic surgery. Liposuction is an effective procedure employed to treat localized adipose deposits in patients not suffering from generalized obesity. These accumulations of subcutaneous fat often occur in predictable distributions in both men and women. A cannula connected to a suction-generating source allows for small incisions to be strategically placed and large volumes of fat to be removed. This fat removal leads to improved harmonious balance of a patient’s physique and improved body contour. Various surgical techniques are available and have evolved as technology has improved. Current technology for liposuction includes suction-assisted lipectomy, ultrasound-assisted, power-assisted, laser-assisted, and radiofrequency-assisted. The choice of technology and technique often depends on patient characteristics and surgeon preference. The objective of this review is to provide a thorough assessment of current technologies available to plastic surgeons performing liposuction. PMID:25093000

  4. Platform for Action: update.

    PubMed

    1995-01-01

    The Center for Women's Global Leadership (CWGL) has collaborated in the preparation of amendments and strategies designed to withstand the challenges being posed to the Platform for Action of the Fourth World Conference on Women. Specific challenges include the inappropriate use of the word "universal" to modify "human rights." This implies that some human rights are less than universal. The strategy proposed is to accept the use of the word "universal" in this context only when it affirms principles of universality contained in the Vienna Programme of Action and not where its use would restrict the rights to which women are entitled. A second concern is over the use of the word "equity" rather than "equality" when referring to gender relations. The use of these terms will be carefully monitored to insure that "equity" not be used to undermine the principle of gender equality. The third concern is the efforts of some governments to hinder the integration of women's human rights throughout the UN system. Such efforts will be opposed. Fourth, the CWGL will seek the inclusion of language which recognizes the barriers that different groups of women face when trying to secure their rights. Finally, the CWGL will propose inclusion of language recognizing and protecting sexual orientation rights. The CWGL is also going to work to translate the abstract language of the Platform for Action into political organizing potential to insure that governments will follow through on their agreements. PMID:12346441

  5. The RHIC status update

    SciTech Connect

    Ozaki, S.

    1995-07-15

    The construction of the Relativistic Heavy Ion Collider (RHIC) began in 1991, with the completion date originally scheduled for 1997. Significant reduction of the funding levels in FY 1993 and 1994, and the funding level cap for FY 1995 and later years caused a 19-month stretchout of the construction period to the second quarter of FY 1999, and an increase of the total estimated cost (TEC) to $475 M. The Project, therefore, is now at the halfway mark of the construction period with actual cost and schedule performance tracking close to the DOE-approved baseline. Construction funding through FY 1994 reached close to 60% of the TEC. Incidentally, if one adds the current value of preexisting facilities which will be incorporated into RHIC, such as the injection system (Tandem Van de Graaff - the Booster - the AGS), the esixting 3.8 km tunnel, the 24 kW helium refrigerator, etc., the total value of the RHIC facility, when completed, will reach one billion dollars, if not more. The accelerator lattice design was finalized in 1992 after an intensive study was made to optimize the collider design for performance, operational flexibility, and value engineering. The civil construciton, including the collider enclosure, magnet access ports to the ring tunnel, and six service buildings for accelerator power supplies and cryogenic control boxes was completed.

  6. Diabetes update: population management.

    PubMed

    Erlich, Deborah R; Slawson, David C; Shaughnessy, Allen

    2013-05-01

    To optimally care for diabetes patients, physicians must adopt a systematic approach to managing the entire panel. At the heart of excellent care is a multidisciplinary health care team working in a patient-centered environment. Options to supplement traditional office visits include shared medical appointments (ie, group visits), patient self-management education, and social media for patient support and education. Educating patients about diabetes is associated with more frequent recommended screening, improved objective measures, cost savings, and improved short-term quality of life, especially when behavioral goal setting is incorporated. Participation in a nurse-led diabetes management program or an outreach program is associated with reduced health care costs and increased receipt of recommended screening and testing for patients with diabetes; implementation of an electronic database or registry system also is associated with these benefits. Some studies show that these interventions are associated with improvements in A1c; however, outcomes data are limited. Formats for group visits vary. Evidence suggests that patients with diabetes who participate in a group education program have lower A1c levels, improved lipid profiles, higher quality of life scores, and improved knowledge about diabetes and problem-solving ability. PMID:23690376

  7. Hedgehog signaling update.

    PubMed

    Cohen, M Michael

    2010-08-01

    In vertebrate hedgehog signaling, hedgehog ligands are processed to become bilipidated and then multimerize, which allows them to leave the signaling cell via Dispatched 1 and become transported via glypicans and megalin to the responding cells. Hedgehog then interacts with a complex of Patched 1 and Cdo/Boc, which activates endocytic Smoothened to the cilium. Patched 1 regulates the activity of Smoothened (1) via Vitamin D3, which inhibits Smoothened in the absence of hedgehog ligand or (2) via oxysterols, which activate Smoothened in the presence of hedgehog ligand. Hedgehog ligands also interact with Hip1, Patched 2, and Gas1, which regulate the range as well as the level of hedgehog signaling. In vertebrates, Smoothened is shortened at its C-terminal end and lacks most of the phosphorylation sites of importance in Drosophila. Cos2, also of importance in Drosophila, plays no role in mammalian transduction, nor do its homologs Kif7 and Kif27. The cilium may provide a function analogous to that of Cos2 by linking Smoothened to the modulation of Gli transcription factors. Disorders associated with the hedgehog signaling network follow, including nevoid basal cell carcinoma syndrome, holoprosencephaly, Smith-Lemli-Opitz syndrome, Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, Carpenter syndrome, and Rubinstein-Taybi syndrome. PMID:20635334

  8. An Update on AGU Publishing

    NASA Astrophysics Data System (ADS)

    Hilst, Rob; Hanson, Brooks

    2013-07-01

    In the past year, AGU publishing has undergone substantial change, and we realize that this has caused some anxiety and concern among you, our members. As the start of a regular Eos series on issues in scientific publishing in general and AGU's content in particular, we provide here an overview and update of recent developments, with an emphasis on the partnership between AGU and Wiley. Topical entries, for instance on open access, will be published later.

  9. MEMS Stirling Cooler Development Update

    NASA Technical Reports Server (NTRS)

    Moran, Matthew E.; Wesolek, Danielle

    2003-01-01

    This presentation provides an update on the effort to build and test a prototype unit of the patented MEMS Stirling cooler concept. A micro-scale regenerator has been fabricated by Polar Thermal Technologies and is currently being integrated into a Stirling cycle simulator at Johns Hopkins University Applied Physics Laboratory. A discussion of the analysis, design, assembly, and test plans for the prototype will be presented.

  10. Imaging in neuroblastoma: An update

    PubMed Central

    Kembhavi, Seema A; Shah, Sneha; Rangarajan, Venkatesh; Qureshi, Sajid; Popat, Palak; Kurkure, Purna

    2015-01-01

    Neuroblastoma is the third common tumor in children. Imaging plays an important role in the diagnosis, staging, treatment planning, response evaluation and in follow-up of a case of Neuroblastoma. The International Neuroblastoma Risk Group task force has recently introduced an imaging-based staging system and laid down guidelines for uniform reporting of imaging studies. This review is an update on imaging in neuroblastoma, with emphasis on these guidelines. PMID:25969636

  11. Atypical odontalgia--an update.

    PubMed

    Patel, Seena B; Boros, Audrey L; Kumar, Satish K S

    2012-09-01

    Atypical odontalgia is a commonly misdiagnosed condition that frequently leads to unnecessary dental treatments such as extraction and endodontic therapy. These treatments often worsen the pain. Despite greater recognition and understanding of this condition, proper diagnosis and treatment remains a challenge. It is believed that atypical odontalgia is a neuropathic condition. This article updates the current understanding of the etiology and pathophysiology of atypical odontalgia, and provides appropriate diagnostic and management approaches for this condition. PMID:23097829

  12. WFGD system materials cost update

    SciTech Connect

    Milobowski, M.G.

    1998-12-31

    This paper is an update of the report ``Economic Comparison of Materials of Construction of Wet FGD Absorbers and Internals`` which was presented at the 1991 EPRI/EPA/DOE SO{sub 2} Control symposium. An economic comparison of the materials standardly used for fabrication of wet FGD spray towers will be presented in this paper. Costs for various materials of construction for such absorber components as spray headers, moisture separators, and gas distribution devices will also be addressed,

  13. Heart Disease and Stroke Statistics—2011 Update

    PubMed Central

    Roger, Véronique L.; Go, Alan S.; Lloyd-Jones, Donald M.; Adams, Robert J.; Berry, Jarett D.; Brown, Todd M.; Carnethon, Mercedes R.; Dai, Shifan; de Simone, Giovanni; Ford, Earl S.; Fox, Caroline S.; Fullerton, Heather J.; Gillespie, Cathleen; Greenlund, Kurt J.; Hailpern, Susan M.; Heit, John A.; Ho, P. Michael; Howard, Virginia J.; Kissela, Brett M.; Kittner, Steven J.; Lackland, Daniel T.; Lichtman, Judith H.; Lisabeth, Lynda D.; Makuc, Diane M.; Marcus, Gregory M.; Marelli, Ariane; Matchar, David B.; McDermott, Mary M.; Meigs, James B.; Moy, Claudia S.; Mozaffarian, Dariush; Mussolino, Michael E.; Nichol, Graham; Paynter, Nina P.; Rosamond, Wayne D.; Sorlie, Paul D.; Stafford, Randall S.; Turan, Tanya N.; Turner, Melanie B.; Wong, Nathan D.; Wylie-Rosett, Judith

    2015-01-01

    Summary Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update. The Statistical Update is a valuable resource for researchers, clinicians, healthcare policy makers, media professionals, the lay public, and many others who seek the best national data available on disease morbidity and mortality and the risks, quality of care, medical procedures and operations, and costs associated with the management of these diseases in a single document. Indeed, since 1999, the Statistical Update has been cited more than 8700 times in the literature (including citations of all annual versions). In 2009 alone, the various Statistical Updates were cited ≈1600 times (data from ISI Web of Science). In recent years, the Statistical Update has undergone some major changes with the addition of new chapters and major updates across multiple areas. For this year’s edition, the Statistics Committee, which produces the document for the AHA, updated all of the current chapters with the most recent nationally representative data and inclusion of relevant articles from the literature over the past year and added a new chapter detailing how family history and genetics play a role in cardiovascular disease (CVD) risk. Also, the 2011 Statistical Update is a major source for monitoring both cardiovascular health and disease in the population, with a focus on progress toward achievement of the AHA’s 2020 Impact Goals. Below are a few highlights from this year’s Update. Death Rates From CVD Have Declined, Yet the Burden of Disease Remains High The 2007 overall death rate from CVD (International Classification of Diseases 10, I00–I99) was 251.2 per 100 000. The rates were 294

  14. Deductive updating is not Bayesian.

    PubMed

    Markovits, Henry; Brisson, Janie; de Chantal, Pier-Luc

    2015-07-01

    One of the major debates concerning the nature of inferential reasoning is between counterexample-based theories such as mental model theory and probabilistic theories. This study looks at conclusion updating after the addition of statistical information to examine the hypothesis that deductive reasoning cannot be explained by probabilistic inferences. In Study 1, participants were given an initial "If P then Q rule" for a phenomenon on a recently discovered planet, told that "Q was true," and asked to make a judgment of either deductive validity or probabilistic likelihood of the putative conclusion that "P is true." They were then told the results of 1,000 observations. In the low-probability problem, 950 times P was false and Q was true, whereas 50 times P was true and Q was true. In the high-probability problem, these proportions were inverted. On the low-probability problem, probabilistic ratings and judgments of logical validity decreased. However, on the high-probability problem, probabilistic ratings remained high whereas judgments of logical validity significantly decreased. Confidence ratings were consistent with this different pattern for probabilistic and for deductive inferences. Study 2 replicated this result with another form of inference, "If P then Q. P is false." These results show that deductive updating is not explicable by Bayesian updating. PMID:25603167

  15. Difficult wounds: an update.

    PubMed

    Edlich, Richard F; Winters, Kathryne L; Britt, L D; Long, William B; Gubler, K Dean; Drake, David B

    2005-01-01

    The purpose of this collective review is to describe revolutionary advances in the treatment of Gardner's syndrome (GS), pseudofolliculitis barbae, nasal septal perforation, factitious wounds, and hidradenitis suppurativa (HS). Gardner's syndrome or familial polyposis has various manifestations that appear to be controlled by a single genetic locus. Apart from the large bowel adenomas, which are always present, a common extracolonic symptom of Gardner's syndrome is the occurrence of epidermal cysts. These cysts can be seen before the intestinal polyps are evident. Because epidermal cysts in patients with Gardner's syndrome are always benign, we excise these cysts using incisions that are commonly used for rhytidectomy. Pseudofolliculitis barbae, a pseudofolliculitis caused by ingrown hairs, effects 85% of blacks who shave their beards. When this disease is allowed to progress to keloid formation, we use a surgical approach that includes excision of the keloidal scar, meticulous debridement of all residual ingrown hairs in the underlying wound, and coverage of the defect with a split-thickness skin graft. More recently, laser therapy has revolutionized the treatment of pseudofolliculitis barbae and has enabled a cure for the first time for those plagued with this disorder and for whom a beardless face is acceptable. Nasal septal perforation is a well recognized complication of septal surgery. Other iatrogenic causes of perforation include cryosurgery, electrocoagulation for epitaxis, nasotracheal intubation, or nose packing. In recent years drugs such as cocaine account for an increasing number of perforations. It has only been with the use of an external approach for the repair of the nasal septal defect that surgical closure has become easier and more reliable. The external approach allows for greater surgical closure and enables the surgeon to use both hands with the aid of binocular vision to mobilize and suture local mucosal advancement flaps and the

  16. Global update: Malaysia.

    PubMed

    1993-01-01

    Malaysia produces more condoms than any other country in the world, yet it has one of the lowest per capita condom usage rates. The official number of HIV-infected persons and of persons with AIDS in Malaysia is 5140 and 72, respectively. People working in AIDS prevention efforts believe the actual number of HIV-infected people is closer to 50,000 and climbing. People working in AIDS prevention efforts believe the actual number of HIV-infected people is closer to 50,000 and climbing. Public health officials report that AIDS is spreading rapidly through Malaysia's relatively large population of IV drug users. The Ministry of Health wants to introduce comprehensive and pragmatic efforts to stem the AIDS epidemic. They include sex education in schools, ways to prevent IV drug users from sharing needles, promotion of condoms among high risk groups, and screening to monitor HIV transmission. Islamic and Catholic groups oppose these program and policy measures, however. The new director of the Ministry's AIDS prevention unit announced during a meeting of health officials that a return to the teaching of Islam and adoption of Islamic values are the means to deal with AIDS. He suggested that boys and girls be separated, television be rigorously censored, and that Muslim scholars not be limited to mosques to do their teaching. The government has greatly increased the 1993 AIDS budget with all of the funds dedicated to blood screening, nongovernmental organizations (NGOs), and health education. The deputy health minister noted that the NGOs are supposed to address the more sensitive issues. The government does not allow any of the funds to directly go to condom promotion or programs for IV drug users, however. PMID:12159245

  17. Hepatopulmonary syndrome: an update.

    PubMed

    Macêdo, Liana Gonçalves de; Lopes, Edmundo Pessoa de Almeida

    2009-07-01

    Hepatopulmonary syndrome (HPS) is a clinical threesome composed of liver disease, intrapulmonary vascular dilatation (IPVD) and arterial gas abnormalities. Its occurrence has been described in up to 32% of cirrhotic candidates for liver transplantation. It also affects non-cirrhotic patients with portal hypertension. Its pathogenesis is not well defined, but an association of factors such as imbalance in the endothelin receptor response, pulmonary microvascular remodeling and genetic predisposition is thought to lead to IPVD. Diagnosis is based on imaging methods that identify these dilatations, such as contrast echocardiography or perfusion scintigraphy with 99mTc, as well as analysis of arterial gases to identify elevated alveolar-arterial differences in O2 or hypoxemia. There is no effective pharmacological treatment and complete resolution only occurs through liver transplantation. The importance of diagnosing HPS lies in prioritizing transplant candidates, since presence of HPS is associated with worse prognosis. The aim of this paper was to review the pathogenetic theories and current diagnostic criteria regarding HPS, and to critically analyze the prioritization of patients with HPS on the liver transplant waiting list. Searches were carried out in the Medline (Medical Literature Analysis and Retrieval System Online) via PubMed, Cochrane Library and Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde) databases for articles published between January 2002 and December 2007 involving adults and written either in English or in Portuguese, using the term hepatopulmonary syndrome. The studies of greatest relevance were included in the review, along with text books and articles cited in references that were obtained through the review. PMID:20011928

  18. Update on Autoimmune Hepatitis

    PubMed Central

    Liberal, Rodrigo; Vergani, Diego; Mieli-Vergani, Giorgina

    2015-01-01

    Autoimmune hepatitis (AIH), a liver disorder affecting both children and adults, is characterized by inflammatory liver histology, elevated transaminase levels, circulating nonorganspecific autoantibodies, and increased levels of immunoglobulin G, in the absence of a known etiology. Two types of AIH are recognized according to seropositivity: smooth muscle antibody and/or antinuclear antibody define AIH type 1 and antibodies to liver-kidney microsome type 1 and/or liver cytosol type 1 define AIH type 2. AIH type 1 affects both adults and children, while AIH type 2 is mainly a paediatric disease, though it does occasionally affects young adults. AIH should be considered during the diagnostic workup of any patient with increased liver enzyme levels. AIH is exquisitely responsive to immunosuppressive treatment with prednisolone with or without azathioprine, with symptom free long-term survival for the majority of patients. For those who do not respond to standard treatment, or who are difficult-to-treat, mycophenolate mofetil and, in the absence of a response, calcineurin inhibitors should be tried in addition to steroids. The pathogenesis of AIH is not fully understood, although there is mounting evidence that genetic susceptibility, molecular mimicry and impaired immunoregulatory networks contribute to the initiation and perpetuation of the autoimmune attack. Liver damage is thought to be mediated primarily by CD4 T-cells, although recent studies support the involvement of diverse populations, including Th17 cells. A deeper understanding of the pathogenesis of AIH is likely to contribute to the development of novel treatments, such as the adoptive transfer of autologous expanded antigenspecific regulatory T-cells, which ultimately aim at restoring tolerance to liver-derived antigens. PMID:26357634

  19. Updates to ISO 21348 (determining solar irradiances)

    NASA Astrophysics Data System (ADS)

    Tobiska, W. Kent

    2012-07-01

    The ISO 21348 (Determining Solar Irradiances) International Standard is going through a document update. A consensus solar spectrum, solar indices/proxies descriptions, solar model descriptions, and solar measurement descriptions are among the Annexes that are proposed to the standard. These topics will be reviewed and described. The International Standards Organization (ISO) published IS 21348 in 2007 after 7 years of development by the international scientific community. In ISO, documents are reviewed on a regular basis and reaffirmed, updated, or deleted according to the votes of national delegations represented in ISO. IS 21348 provides guidelines for specifying the process of determining solar irradiances. Solar irradiances are reported through products such as measurement sets, reference spectra, empirical models, theoretical models and solar irradiance proxies or indices. These products are used in scientific and engineering applications to characterize within the natural space environment solar irradiances that are relevant to space systems and materials. Examples of applications using input solar irradiance energy include the determination of atmospheric densities for spacecraft orbit determination, attitude control and re-entry calculations, as well as for debris mitigation and collision avoidance activity. Direct and indirect pressure from solar irradiance upon spacecraft surfaces also affects attitude control separately from atmospheric density effects. Solar irradiances are used to provide inputs for a) calculations of ionospheric parameters, b) photon-induced radiation effects, and c) radiative transfer modeling of planetary atmospheres. Input solar irradiance energy is used to characterize material properties related to spacecraft thermal control, including surface temperatures, reflectivity, absorption and degradation. Solar energy applications requiring a standard process for determining solar irradiance energy include i) solar cell power

  20. Library Software: A Guide to the Current Commercial Products: 1997 Update.

    ERIC Educational Resources Information Center

    Breeding, Marshall

    1997-01-01

    Provides an update to the list of companies that offer commercial library software and describes the systems and tools they offer. Integrated library systems, networking systems, bibliographic software, and other library applications are included. (LRW)

  1. Nastran level 16 theoretical manual updates for aeroelastic analysis of bladed discs

    NASA Technical Reports Server (NTRS)

    Elchuri, V.; Smith, G. C. C.

    1980-01-01

    A computer program based on state of the art compressor and structural technologies applied to bladed shrouded disc was developed and made operational in NASTRAN Level 16. Aeroelastic analyses, modes and flutter. Theoretical manual updates are included.

  2. MedlinePlus FAQ: What's New on Medline Plus Page and Email Updates

    MedlinePlus

    ... the What's New on MedlinePlus page and RSS feed different from the email updates? To use the ... The What's New on MedlinePlus page and RSS feed include alerts about new MedlinePlus features, useful resources, ...

  3. [Gout management: an update].

    PubMed

    Ankli, Barbara; Krähenbühl, Stephan

    2016-01-01

    Gout is the most frequent arthritis worldwide. Despite progress in therapeutic options the majority of gout patients are still insufficiently treated. International guidelines (ACR, EULAR, 3e initiative) clearly specify treatment targets: keep the patient flare-free and maintain a low urate serum level (< 360 µmol/l). The treat to target strategy includes therapy of flares, urate lowering treatment (ULT) and prophylaxis of flares. Evolution of gout guidelines over several years shows a broader indication for ULT, mandatory prophylaxis of flares during the initiation of ULT over several months and an earlier start of ULT in patients with flares as soon as symptoms have diminished. Colchicine is the preferred specific flare treatment, Caution has to be taken especially in patients with kidney disease, patients with hepatic dysfunction or in patients with interacting comedication. Low dose oral colchicine is nowadays the standard flare treatment. NSAIDs and prednisone are valuable alternatives. Interleukin-1 blockers offer a quick resolution of flares and may be an option in patients with chronic gout and severe kidney disease. Xanthinoxidase inhibitors (XOI) are the mainstay of ULT, with allopurinol still being the preferred XOI. The recently approved XOI febuxostat is eliminated mostly by the liver and can induce a faster lowering of urate. Uricosuric drugs such as probenecid are recommended in patients with sufficient renal function in whom the treatment goals cannot be reached with XOI. In Switzerland, only the two gout-lowering drugs allopurinol and probenecid are available, which reduces the therapeutic possibilities. Treatment success is often hampered by malcompliance. Recent guidelines stress the importance of patient education to ameliorate compliance. Comorbidities such as metabolic syndrome, cardiovascular and kidney disease are often found in gout patients. Patients with severe kidney disease are the most difficult to treat: the choice of

  4. Progress on Updating the 1961-1990 National Solar Radiation Database

    NASA Technical Reports Server (NTRS)

    Renne, D.; Wilcox, S.; Marion, B.; George, R.; Myers, D.

    2003-01-01

    The 1961-1990 National Solar Radiation Data Base (NSRDB) provides a 30-year climate summary and solar characterization of 239 locations throughout the United States. Over the past several years, the National Renewable Energy Laboratory (NREL) has received numerous inquiries from a range of constituents as to whether an update of the database to include the 1990s will be developed. However, there are formidable challenges to creating an update of the serially complete station-specific database for the 1971-2000 period. During the 1990s, the National Weather Service changed its observational procedures from a human-based to an automated system, resulting in the loss of important input variables to the model used to complete the 1961-1990 NSRDB. As a result, alternative techniques are required for an update that covers the 1990s. This paper examines several alternative approaches for creating this update and describes preliminary NREL plans for implementing the update.

  5. 8th edition of the Table of Isotopes: 1998 Update

    NASA Astrophysics Data System (ADS)

    Firestone, Richard B.; Chu, S. Y. Frank; Baglin, Coral M.

    1997-10-01

    The 8th edition of the Table of Isotopes (John Wiley, New York) was published in 1996 as both a two-volume book and a CD-ROM. A 1998 update to the 8th edition CD-ROM is nearly completed. The 1998 update will include data added to the Evaluated Nuclear Structure Data File (ENSDF) since about 1995. Special effort was taken, for this update, to revise ENSDF for nuclides far-from-stability, superdeformed bands, and spontaneous fission. The update will contain data for over 3600 isotopes and isomers, nearly 500 more than the previous edition. The Table of Isotopes is being prepared in Acrobat PDF format and provided with Acrobat Reader software for most computers. This new version will be Internet enabled including local HTML links to additional data for nuclear astrophysics, atomic masses, radioactive decay, fission yields, and other information. The CD-ROM will also contain the ENSDF and Nuclear Science Reference (NSR) files. Isotope Explorer software (PC) will be provided to search the ENSDF database to display level scheme drawings, data tables, plots, nuclear charts, and to perform literature searches. An Internet publication of the Table of Isotopes is under developement.

  6. NEWS: Post-16 update

    NASA Astrophysics Data System (ADS)

    Campbell, Peter

    2000-07-01

    sometimes hard-to-come-by information, insightful and occasionally witty comment and illustration. The fifth booklet, published in April this year, rounds off the series so far. For those who have not yet seen them, here are the questions that the booklets have explored: Making Physics Connect (editor: Peter Campbell). How can physics courses connect better with the learner and with other human activities and areas of knowledge? Physics in Mathematical Mood (editor: Simon Carson). How can we teach physics in an appropriately mathematical way, conveying the beauty and power of mathematical reasoning to students? Physics in Vocational Courses (editor: Ken Gadd). In the new National Qualifications Framework, what role should physics play in the `general vocational' and `vocational' pathways? The Study of Matter (editor: Claire Davis). What aspects of a wide and interdisciplinary subject should be included in courses at advanced level, and how can these best be taught? Revitalising Physics Education (editor: Andrew Morris). What can we learn from histories of physics and of education, or from curriculum development projects of the last thirty years? What can be said about teaching and learning physics beyond qualifications, or learned from international developments in physics education? These booklets should find their way into every physics department in the UK. They will be of immediate practical use in schools or colleges, informing teaching while also providing stimulus material for discussion among physics teachers. (The latter would rightly be called in-service training.) Student teachers will find them a good guide covering new terrain. Lecturers at higher education level will gain valuable insight into changes affecting their undergraduate intake. And the physics advisory committee of every Awarding Body will surely want to discuss issues raised in the booklets. The main message overall is that, to meet tomorrow's challenges, the many parties involved in physics

  7. NEWS: Post-16 update

    NASA Astrophysics Data System (ADS)

    Campbell, Peter

    2000-07-01

    sometimes hard-to-come-by information, insightful and occasionally witty comment and illustration. The fifth booklet, published in April this year, rounds off the series so far. For those who have not yet seen them, here are the questions that the booklets have explored: Making Physics Connect (editor: Peter Campbell). How can physics courses connect better with the learner and with other human activities and areas of knowledge? Physics in Mathematical Mood (editor: Simon Carson). How can we teach physics in an appropriately mathematical way, conveying the beauty and power of mathematical reasoning to students? Physics in Vocational Courses (editor: Ken Gadd). In the new National Qualifications Framework, what role should physics play in the `general vocational' and `vocational' pathways? The Study of Matter (editor: Claire Davis). What aspects of a wide and interdisciplinary subject should be included in courses at advanced level, and how can these best be taught? Revitalising Physics Education (editor: Andrew Morris). What can we learn from histories of physics and of education, or from curriculum development projects of the last thirty years? What can be said about teaching and learning physics beyond qualifications, or learned from international developments in physics education? These booklets should find their way into every physics department in the UK. They will be of immediate practical use in schools or colleges, informing teaching while also providing stimulus material for discussion among physics teachers. (The latter would rightly be called in-service training.) Student teachers will find them a good guide covering new terrain. Lecturers at higher education level will gain valuable insight into changes affecting their undergraduate intake. And the physics advisory committee of every Awarding Body will surely want to discuss issues raised in the booklets. The main message overall is that, to meet tomorrow's challenges, the many parties involved in physics

  8. NEWS: Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-05-01

    (post16) Making physics connect Doesn't Melvyn Bragg do a wonderful job, engaging both scientists and artists in sensitive discussion on Radio 4 about their methods and their purposes? But every week teachers have the chance to show their students that physics is a way of seeing the world that is well-connected with other aspects of knowledge and culture. The stakes are high: students who fail to appreciate this generally choose not to study the subject beyond GCSE. Most students find our preoccupation with technical detail off-putting. Accepting that we have a syllabus to cover, it's still a question of balance. In our teaching we should aim for variety in order to find ways to connect with every student's interests. Also, we can show that we (the nearest embodiment of a physicist some students will experience) are multidimensional and so fully human. Most important, teachers need flexibility to both encourage and respond to student comment and questions. The first booklet in the discussion series Shaping the Future takes up these themes. Rich in ideas for both immediate use and the longer term, it aims to stimulate debate and improve teaching. Copies cost £5.50 including postage and are available from Ingrid Ebeyer, Post-16 Initiative, Institute of Physics, 76 Portland Place, London W1N 3DH. How far is it? This question is asked in many family cars and school minibuses at the start of a journey, and answered by most in terms of hours and minutes rather than miles. What a good idea for introducing a social and historical perspective to a lesson on distance, velocity and time. How far can you actually get in a day? What is the range of human activity? Walking for eight hours will get many people about 25 miles. A pack horse will progress at much the same rate, but fast riding or a coach and team of horses will get further. Motorway driving (when the cones are on holiday) would take you nearly 500 miles. The 05.15 am train from Penzance arrives in Inverness at 7

  9. Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-11-01

    . Provided the tasks are well defined and the marking criteria are straightforward to apply, internally assessed work provides an opportunity for real positive achievement; students are able to control the task they set themselves, and have every opportunity to maximize their marks. In the past most syllabuses used the coursework simply to assess experimental and investigative skills, through a series of experiments or a practical investigation. Two of the new specifications have taken the opportunity to broaden the scope of coursework. The Edexcel Salters - Horners Advanced Physics AS course includes a report on a visit. Students must make a visit to an establishment where physics is in action, and then report on how physics is used there. The visit may be to a local garage, supermarket or hospital, but could use any other local resource - or indeed justify that trip to CERN. The location of the visit is limited only by the imagination of teachers and students. In the AS course of OCR Advancing Physics students must make a presentation about a material they have studied. The presentation may be a talk, a poster or even a series of web pages. This gives students the opportunity to demonstrate their key skills in communication alongside collecting some marks towards their AS in Physics. In the A2 year students develop their research skills further by producing a research report on a topic of their choice. Students must show how they can draw together ideas from different aspects of physics in discussing their chosen subject. These two developments lead the way in encouraging teachers and examiners to take physics out of the school laboratory and into the world. Mary Whitehouse

  10. Drug Interactions with Lithium: An Update.

    PubMed

    Finley, Patrick R

    2016-08-01

    Lithium has been used for the management of psychiatric illnesses for over 50 years and it continues to be regarded as a first-line agent for the treatment and prevention of bipolar disorder. Lithium possesses a narrow therapeutic index and comparatively minor alterations in plasma concentrations can have significant clinical sequelae. Several drug classes have been implicated in the development of lithium toxicity over the years, including diuretics and non-steroidal anti-inflammatory compounds, but much of the anecdotal and experimental evidence supporting these interactions is dated, and many newer medications and medication classes have been introduced during the intervening years. This review is intended to provide an update on the accumulated evidence documenting potential interactions with lithium, with a focus on pharmacokinetic insights gained within the last two decades. The clinical relevance and ramifications of these interactions are discussed. PMID:26936045

  11. Hubble Space Telescope Battery Capacity Update

    NASA Technical Reports Server (NTRS)

    Hollandsworth, Roger; Armantrout, Jon; Rao, Gopalakrishna M.

    2007-01-01

    Orbital battery performance for the Hubble Space Telescope is discussed and battery life is predicted which supports decision to replace orbital batteries by 2009-2010 timeframe. Ground characterization testing of cells from the replacement battery build is discussed, with comparison of data from battery capacity characterization with cell studies of Cycle Life and 60% Stress Test at the Naval Weapons Surface Center (NWSC)-Crane, and cell Cycle Life testing at the Marshal Space Flight Center (MSFC). The contents of this presentation includes an update to the performance of the on-orbit batteries, as well as a discussion of the HST Service Mission 4 (SM4) batteries manufactured in 1996 and activated in 2000, and a second set of SM4 backup replacement batteries which began manufacture Jan 11, 2007, with delivery scheduled for July 2008.

  12. Skin infections in returned travelers: an update.

    PubMed

    Zimmerman, Robert F; Belanger, Elizabeth S; Pfeiffer, Christopher D

    2015-03-01

    Dermatologic manifestations of travel-related illness are particularly vexing due to the broad differential diagnosis and clinicians' unfamiliarity with uncommonly seen diseases. This paper aims to educate and update the reader on selected infectious diseases in the returned traveler whose disease manifestations are primarily dermatologic. First, the evolving epidemiology of these infections is examined; understanding the geographic distribution of infectious etiologies helps refine and narrow the differential diagnosis. This is followed by a discussion of six important clinical syndromes including cutaneous larva migrans (CLM), cutaneous leishmaniasis, tungiasis, myiasis, antibiotic-resistant skin and soft tissue infection, and selected infections associated with fever and rash (e.g., measles, chikungunya virus infection, dengue fever, rickettsial spotted fevers). Familiarity with these syndromes and a situational awareness of their epidemiology will facilitate a prompt, accurate diagnosis and lead to appropriate treatment and prevention of further disease spread. PMID:25821190

  13. Stem cells news update: a personal perspective.

    PubMed

    Wong, Sc

    2013-12-01

    This article is a follow-up to a previous Commentary published in 2011. It updates some of the events mentioned in that Commentary and continues with more interesting and exciting news on stem cell research and the emerging field of Regenerative Medicine. Some of the news includes: 1) the 2012 Nobel Prize for Medicine awarded to John B. Gurdon and Shinya Yamanaka; 2) the cloning of human embryonic stem cells; 3) the continued search for truly pluripotent adult stem cells via in vitro and in vivo protocols; 4) the breakthrough in organ replacements; 5) the global stem cell race; 6) the global stem cell cryo-preservation business; 7) the worldwide stem cell donor registries, and 8) the issue of government regulation on stem cell therapy. PMID:24778557

  14. Solar radiation on Mars: Update 1990

    NASA Technical Reports Server (NTRS)

    Appelbaum, Joseph; Flood, Dennis J.

    1990-01-01

    Detailed information on solar radiation characteristics on Mars are necessary for effective design of future planned solar energy systems operating on the surface of Mars. The authors present a procedure and solar radiation related data from which the diurnally and daily variation of the global, direct beam and diffuse insolation on Mars are calculated. The radiation data are based on measured optical depth of the Martian atmosphere derived from images taken of the Sun with a special diode on the Viking Lander cameras and computation based on multiple wavelength and multiple scattering of the solar radiation. This work is an update to NASA-TM-102299 and includes a refinement of the solar radiation model.

  15. An Update on the KFIB Experiment

    SciTech Connect

    Youngblood, Gerald E.; Jones, Russell H.; Kowbel, W.; De Heij, Paul; Kohyama, Akira

    2001-06-30

    An updated sample test matrix for the KFIB experiment is presented. The pre-irradiation test results for all fiber and SiC/SiC composite materials included in the test matrix, recently presented at the 4th IEA Workshop on SiC/SiC for Fusion Structural Applications held in Frascati, Italy, October 12-13, 2000, are reviewed. The KFIB samples have been delivered for capsule loading. They are scheduled to be irradiated from May through October, 2001 to similar doses (2-4 dpa-SiC) in the ATR (Idaho Falls) at 300?C and the HFR (Petten) at 625 and 975?C. To assess irradiation enhanced creep (IEC) in SiC fibers, a bend stress relaxation module was added to the HFR sample matrix at each irradiation temperature.

  16. Resource Tracking Model Updates and Trade Studies

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe; Stambaugh, Imelda; Moore, Michael

    2016-01-01

    The Resource tracking model has been updated to capture system manager and project manager inputs. Both the Trick/GUNNS RTM simulator and the RTM mass balance spreadsheet have been revised to address inputs from system managers and to refine the way mass balance is illustrated. The revisions to the RTM included addition of a Plasma Pyrolysis Assembly (PPA) to recover hydrogen from Sabatier reactor methane which was vented in the prior version of the RTM. The effect of the PPA on the overall balance of resources in an exploration vehicle is illustrated in the increased recycle of vehicle oxygen. Additionally simulation of EVAs conducted from the exploration module was added. Since the focus of the exploration module is to provide a habitat during deep space operations the EVA simulation approach to EVA is based on ISS EVA protocol and processes. Case studies have been run to show the relative effect of performance changes on vehicle resources.

  17. Resource Tracking Model Updates and Trade Studies

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe; Stambaugh, Imelda; Moore, Michael

    2016-01-01

    The Resource Tracking Model has been updated to capture system manager and project manager inputs. Both the Trick/General Use Nodal Network Solver Resource Tracking Model (RTM) simulator and the RTM mass balance spreadsheet have been revised to address inputs from system managers and to refine the way mass balance is illustrated. The revisions to the RTM included the addition of a Plasma Pyrolysis Assembly (PPA) to recover hydrogen from Sabatier Reactor methane, which was vented in the prior version of the RTM. The effect of the PPA on the overall balance of resources in an exploration vehicle is illustrated in the increased recycle of vehicle oxygen. Case studies have been run to show the relative effect of performance changes on vehicle resources.

  18. Update on GOCART Model Development and Applications

    NASA Technical Reports Server (NTRS)

    Kim, Dongchul

    2013-01-01

    Recent results from the GOCART and GMI models are reported. They include: Updated emission inventories for anthropogenic and volcano sources, satellite-derived vegetation index for seasonal variations of dust emission, MODIS-derived smoke AOT for assessing uncertainties of biomass-burning emissions, long-range transport of aerosol across the Pacific Ocean, and model studies on the multi-decadal trend of regional and global aerosol distributions from 1980 to 2010, volcanic aerosols, and nitrate aerosols. The document was presented at the 2013 AEROCENTER Annual Meeting held at the GSFC Visitors Center, May 31, 2013. The Organizers of the meeting are posting the talks to the public Aerocentr website, after the meeting.

  19. Stem Cells News Update: A Personal Perspective

    PubMed Central

    Wong, SC

    2013-01-01

    This article is a follow-up to a previous Commentary published in 2011. It updates some of the events mentioned in that Commentary and continues with more interesting and exciting news on stem cell research and the emerging field of Regenerative Medicine. Some of the news includes: 1) the 2012 Nobel Prize for Medicine awarded to John B. Gurdon and Shinya Yamanaka; 2) the cloning of human embryonic stem cells; 3) the continued search for truly pluripotent adult stem cells via in vitro and in vivo protocols; 4) the breakthrough in organ replacements; 5) the global stem cell race; 6) the global stem cell cryo-preservation business; 7) the worldwide stem cell donor registries, and 8) the issue of government regulation on stem cell therapy. PMID:24778557

  20. Neuromyelitis optica spectrum disorders: An update

    PubMed Central

    Pandit, Lekha

    2015-01-01

    Recent advances in the understanding of neuromyelitis optica spectrum of disorders (NMOSD) have expanded. Diagnostic criteria have changed over the years. The clinical spectrum of disease manifestations are now understood to include sites outside the spinal cord and optic nerve. A variety of autoimmune diseases may coexist with this disorder. Non neurological manifestations have been recently reported. Novel biomarkers other than aquoporin 4 Immunoglobulin G (anti AQP4-IgG) have been discovered which may have clinical relevance. In particul myelin associated oligoglycoprotein antibody (MOG-Ab) associated NMOSD may be relatively benign. This update describes some of these new findings highlighting the clinical manifestations, biomarkers associated with the disease and magnetic resonance imaging characteristics of brain and spinal cord. PMID:26538842

  1. CALIPSO Mission Status Update: Payload Status

    NASA Technical Reports Server (NTRS)

    Verhappen, Ron; Borchardt, Robert; MacDonnell, David; Cisewski, Mike

    2007-01-01

    The CALIPSO mission payload status update is presented. The contents include: 1) Wide Field Camera Overview; 2) WFC Temperatures; 3) WFC Voltages; 4) Imaging Infrared Radiometer (IIR) Health; 5) IIR Voltages; 6) Payload Control (PLC) Voltages; 7) PLC Temperatures; 8) Low Voltage Power Supply (LVPS) (CALOPS0025N); 9) PLC Radiation Effects; 10) SDS Status (CALOPS0020N); 11) CALIOP LIDAR; 12) Laser Energy Trends; 13) Laser Energy Zoom; 14) Laser Management Approach; 15) Green / Red Ratio; 16) Pedestal @ SHG Temperature Trends; 17) LOM Heater Duty Cycle Trends; 18) LOM Pressure Trends; 19) Boresight Trend; 20) 1064 Dark Noise Trend; 21) 532 SNR Trend; 22) Spike Trends; 23) LIDAR Highlights; 24) Backup Laser Status; and 25) Future Plans.

  2. The pediatric cardiology pharmacopeia: 2013 update.

    PubMed

    Severin, Paul Nicholas; Awad, Sawsan; Shields, Beth; Hoffman, Joan; Bonney, William; Cortez, Edmundo; Ganesan, Rani; Patel, Aloka; Barnes, Steve; Barnes, Sean; Al-Anani, Shada; Gupta, Umang; Cheddar, Yolandee Bell; Gonzalez, Ismael E; Mallula, Kiran; Ghawi, Hani; Kazmouz, Suhaib; Gendi, Salwa; Abdulla, Ra-id

    2013-01-01

    The use of medications plays a pivotal role in the management of children with heart diseases. Most children with increased pulmonary blood flow require chronic use of anticongestive heart failure medications until more definitive interventional or surgical procedures are performed. The use of such medications, particularly inotropic agents and diuretics, is even more amplified during the postoperative period. Currently, children are undergoing surgical intervention at an ever younger age with excellent results aided by advanced anesthetic and postoperative care. The most significant of these advanced measures includes invasive and noninvasive monitoring as well as a wide array of pharmacologic agents. This review update provides a medication guide for medical practitioners involved in care of children with heart diseases. PMID:23192622

  3. Update on the epidemiology of osteoporosis.

    PubMed

    Wolf, R L; Zmuda, J M; Stone, K L; Cauley, J A

    2000-02-01

    Osteoporosis is a major public health problem that affects the entire aging population. This report provides an update on the epidemiology of osteoporosis and its associated fractures. Published studies from 1997 to the present are highlighted. The current US prevalence estimates for osteoporosis, trends in fracture incidence rates, and latest reports on the morbidity, mortality, and costs attributable to osteoporotic fractures are discussed. Recent advances in our understanding of risk factors associated with osteoporosis and related fractures are reviewed. Special attention is paid to the rapid progress being made in the field of genetics, the growing importance of nutrition, and the new questions being raised as to the influence of hormonal factors on bone mineral density and fracture risk. New studies linking osteoporosis to several other important diseases in women including breast cancer, osteoarthritis, and stroke are also reviewed. PMID:11123043

  4. Biologic therapy for autoimmune diseases: an update

    PubMed Central

    2013-01-01

    Biologic therapies for rheumatologic diseases, which are targeted at molecules involved in the mechanisms of the immune system, provide an alternative to the existing treatment methods of disease-modifying anti-rheumatic drugs and other immunosuppressive medications. However, the current drawbacks of biologic therapies, including the inconvenience of intravenous administration, the high costs of these drugs, and the adverse events associated with them, prevent their wide use as first-line medications. This review provides an update of the recent literature on the new biologic therapies available. The review concentrates on nine drugs: tocilizumab, rituximab, ofatumumab, belimumab, epratuzumab, abatacept, golimumab, certolizumab, and sifalimumab, which are used as therapies for rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, systemic sclerosis, or vasculitis. PMID:23557513

  5. THE MAJORANA DEMONSTRATOR: OVERVIEW AND STATUS UPDATE

    SciTech Connect

    Keeter, K.; Abgrall, N.; Aguayo, Estanislao; Avignone, F. T.; Barabash, Alexander; Bertrand, F.; Boswell, M.; Brudanin, V.; Busch, Matthew; Caldwell, A. S.; Chan, Yuen-Dat; Christofferson, Cabot-Ann; Combs, Dustin C.; Cuesta, C.; Detwiler, Jason A.; Doe, Peter J.; Efremenko, Yuri; Egorov, Viatcheslav; Ejiri, H.; Elliott, S.; Esterline, James H.; Fast, James E.; Finnerty, P.; Fraenkle, Florian; Galindo-Uribarri, A.; Giovanetti, G. K.; Goett, J.; Green, Matthew P.; Gruszko, J.; Guiseppe, Vincente; Gusev, K.; Hallin, A. L.; Hazama, R.; Hegai, A.; Henning, Reyco; Hoppe, Eric W.; Howard, Stanley; Howe, M. A.; Kidd, M. F.; Kochetov, Oleg; Konovalov, S.; Kouzes, Richard T.; LaFerriere, Brian D.; Leon, Jonathan D.; Leviner, L.; Loach, J. C.; MacMullin, S.; Martin, R. D.; Mertens, S.; Mizouni, Leila; Nomachi, Masaharu; O'Shaughnessy, Mark D.; Orrell, John L.; Overman, Nicole R.; Phillips, D.; Poon, Alan; Pushkin, K.; Radford, D. C.; Rielage, Keith; Robertson, R. G. H.; Ronquest, M. C.; Schubert, Alexis G.; Shanks, B.; Shima, T.; Shirchenko, M.; Snavely, Kyle J.; Snyder, N.; Soin, Aleksandr; Strain, J.; Suriano, Anne-Marie; Swift, Gary; Thompson, J.; Timkin, V.; Tornow, Werner; Varner, R. L.; Vasilyev, Sergey; Vetter, Kai; Vorren, Kris R.; White, Brandon R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Young, A.; Yu, Chang-Hong; Yumatov, Vladimir

    2013-04-12

    The MAJORANA DEMONSTRATOR is being constructed at the Sanford Underground Research Facility (SURF) in Lead, SD by the MAJORANA Collaboration to demonstrate the feasibility of a tonne-scale neutrinoless double beta decay experiment based on 76Ge. The observation of neutrinoless double beta decay would indicate that neutrinos can serve as their own antiparticles, thus proving neutrinos to be Majorana particles, and would give information on neutrino masses. Attaining sensitivities for neutrino masses in the inverted hierarchy region requires large tonne-scale detectors with extremely low backgrounds. The DEMONSTRATOR project will show that sufficiently low backgrounds are achievable. A brief description of the detector and a status update on the construction will be given, including the work done at BHSU on acid-etching of Pb shielding bricks.

  6. Sellafield Decommissioning Programme - Update and Lessons Learned

    SciTech Connect

    Lutwyche, P. R.; Challinor, S. F.

    2003-02-24

    The Sellafield site in North West England has over 240 active facilities covering the full nuclear cycle from fuel manufacture through generation, reprocessing and waste treatment. The Sellafield decommissioning programme was formally initiated in the mid 1980s though several plants had been decommissioned prior to this primarily to create space for other plants. Since the initiation of the programme 7 plants have been completely decommissioned, significant progress has been made in a further 16 and a total of 56 major project phases have been completed. This programme update will explain the decommissioning arrangements and strategies and illustrate the progress made on a number of the plants including the Windscale Pile Chimneys, the first reprocessing plan and plutonium plants. These present a range of different challenges and requiring approaches from fully hands on to fully remote. Some of the key lessons learned will be highlighted.

  7. Environmental Chemistry Update

    NASA Astrophysics Data System (ADS)

    1995-08-01

    the OH/HOO reaction chain is responsible for 30-50% of the ozone loss in the low stratosphere. Chains involving nitrogen radicals are less important in this region than previously thought. Almost one-third of the loss is due to cycles involving halogens, including that initiated by collision of ClO with Br. Equally important is the following cycle, reminiscent of the "dimer" mechanism that operates in ozone holes, for the 2O3 --> 3O2 process. Cl + O3 --> ClO + O2 OH + O3 --> HOO + O2 ClO + HOO --> HOCl + O2 HOCl + sunlight --> OH + Cl The same mechanism with bromine replacing chlorine is also important. The greatest removal rate for ozone at these latitudes should occur in spring and fall, when ozone production is minimal. Although the sunlight then is not sufficient to dissociate much O2, it is adequate to drive the free radical processes (7). The feasibility of A. Y. Wong's scheme to reduce stratospheric ozone destruction due to reactions involving chlorine has been questioned. The scheme involves the introduction of electrons into the stratosphere, which would allow the conversion of chlorine to chloride ion and its hydrates and potentially the subsequent removal of the chloride ions. A. A. Viggiano and colleagues have noted that chloride ions react quickly after their formation (to reform chlorine radicals) and never amount to more than a tiny fraction of the anions present. The dominant ions are NO3- and CO3-. Viggiano et al. also note the very large energy requirements for the electron production and for removal of the 2.4 X 10^9 kg of chlorine from the stratosphere (8). Pesticides and DioxinGreat LakesThe herbicide atrazine and its metabolite, in which the nitrogen-based ethyl group is removed, were found in all 490 samples of water from the Great Lakes in a 1990-1992 study. Highest concentrations of atrazine were found in Lakes Ontario and Erie (70-110 parts per trillion (ppt)), with lower levels (20-35 ppt) in Lakes Huron and Michigan. It was estimated that

  8. An update to the Greig Health Record: Executive summary.

    PubMed

    Greig, Anita Arya; Constantin, Evelyn; LeBlanc, Claire Ma; Riverin, Bruno; Li, Patricia Tak-Sam; Cummings, Carl

    2016-01-01

    The Greig Health Record is an evidence-based health promotion guide for clinicians caring for children and adolescents 6 to 17 years of age. It provides a template for periodic health visits that is easy to use and adaptable for electronic medical records. On the record, the strength of recommendations is indicated in boldface for good, in italics for fair, and in regular typeface for recommendations based on consensus or inconclusive evidence. Checklist templates include sections for Weight, Height and BMI, Psychosocial history and Development, Nutrition, Education and Advice, Specific Concerns, Examination, Assessment, Immunization, and Medications. Included with the checklist tables are five pages of selected guidelines and resources. This update includes information from recent guidelines and research in preventive care for children and adolescents 6 to 17 years of age. Regular updates are planned. The complete Greig Health Record can be found online at the Canadian Paediatric Society's website: www.cps.ca. PMID:27441024

  9. The universal tree of life: an update

    PubMed Central

    Forterre, Patrick

    2015-01-01

    Biologists used to draw schematic “universal” trees of life as metaphors illustrating the history of life. It is indeed a priori possible to construct an organismal tree connecting the three major domains of ribosome encoding organisms: Archaea, Bacteria and Eukarya, since they originated by cell division from LUCA. Several universal trees based on ribosomal RNA sequence comparisons proposed at the end of the last century are still widely used, although some of their main features have been challenged by subsequent analyses. Several authors have proposed to replace the traditional universal tree with a ring of life, whereas others have proposed more recently to include viruses as new domains. These proposals are misleading, suggesting that endosymbiosis can modify the shape of a tree or that viruses originated from the last universal common ancestor (LUCA). I propose here an updated version of Woese’s universal tree that includes several rootings for each domain and internal branching within domains that are supported by recent phylogenomic analyses of domain specific proteins. The tree is rooted between Bacteria and Arkarya, a new name proposed for the clade grouping Archaea and Eukarya. A consensus version, in which each of the three domains is unrooted, and a version in which eukaryotes emerged within archaea are also presented. This last scenario assumes the transformation of a modern domain into another, a controversial evolutionary pathway. Viruses are not indicated in these trees but are intrinsically present because they infect the tree from its roots to its leaves. Finally, I present a detailed tree of the domain Archaea, proposing the sub-phylum neo-Euryarchaeota for the monophyletic group of euryarchaeota containing DNA gyrase. These trees, that will be easily updated as new data become available, could be useful to discuss controversial scenarios regarding early life evolution. PMID:26257711

  10. The universal tree of life: an update.

    PubMed

    Forterre, Patrick

    2015-01-01

    Biologists used to draw schematic "universal" trees of life as metaphors illustrating the history of life. It is indeed a priori possible to construct an organismal tree connecting the three major domains of ribosome encoding organisms: Archaea, Bacteria and Eukarya, since they originated by cell division from LUCA. Several universal trees based on ribosomal RNA sequence comparisons proposed at the end of the last century are still widely used, although some of their main features have been challenged by subsequent analyses. Several authors have proposed to replace the traditional universal tree with a ring of life, whereas others have proposed more recently to include viruses as new domains. These proposals are misleading, suggesting that endosymbiosis can modify the shape of a tree or that viruses originated from the last universal common ancestor (LUCA). I propose here an updated version of Woese's universal tree that includes several rootings for each domain and internal branching within domains that are supported by recent phylogenomic analyses of domain specific proteins. The tree is rooted between Bacteria and Arkarya, a new name proposed for the clade grouping Archaea and Eukarya. A consensus version, in which each of the three domains is unrooted, and a version in which eukaryotes emerged within archaea are also presented. This last scenario assumes the transformation of a modern domain into another, a controversial evolutionary pathway. Viruses are not indicated in these trees but are intrinsically present because they infect the tree from its roots to its leaves. Finally, I present a detailed tree of the domain Archaea, proposing the sub-phylum neo-Euryarchaeota for the monophyletic group of euryarchaeota containing DNA gyrase. These trees, that will be easily updated as new data become available, could be useful to discuss controversial scenarios regarding early life evolution. PMID:26257711

  11. Development of Updated ABsorption SIMulation Software (ABSIM)

    SciTech Connect

    Yang, Zhiyao; Tang, Xin; Qu, Ming; Abdelaziz, Omar; Gluesenkamp, Kyle R

    2014-01-01

    ABsorption SIMulation, ABSIM, was developed for the simulation of absorption systems by The Oak Ridge National Laboratory during 1980s and 1990s. ABSIM provides a platform for users to investigate various cycle configurations and working fluids, to calculate their operating parameters, to predict their performance, and to compare them with each other on a uniform basis. ABSIM is indeed a very useful and accurate tool for researchers to investigate various absorption systems. However, it has not been well maintained: it is incompatible with recent operating systems; the interface needs improved user-friendliness, and the system needs better parameter setting and debugging tools to help achieve convergence. Therefore, it is highly needed to update and improve ABSIM. The paper presents recent efforts to improve ABSIM s compatibility with current operating systems, user interface, and analysis capabilities. The paper details the features and functions of the newly updated ABSIM software. The new ABSIM still uses the previously validated calculation engine of the old ABSIM. The new graphic user interfaces (GUI) were developed in Qt, which is an open source license GUI software based on C++. XML was used as the database for data storage in the new ABSIM. The new ABSIM has been designed to be easily learned and used. It has enhanced editing and construction functions, plus enhanced analysis features including parametric tables, plotting, property plots, and master panels for debugging. A single effect water/LiBr absorption system is used as a case study in this paper to illustrate the features, capabilities, and functions of the new ABSIM. This case study was actually an example system available in the old ABSIM. The new version of ABSIM will be continuously developed to include additional subroutines for the components in liquid desiccant systems. The new ABSIM will be available to public for free. The ultimate goal of the new ABSIM is to allow it to become a simulation

  12. Updating knowledge bases with disjunctive information

    SciTech Connect

    Zhang, Yan; Foo, Norman Y.

    1996-12-31

    It is well known that the minimal change principle was widely used in knowledge base updates. However, recent research has shown that conventional minimal change methods, eg. the PMA, are generally problematic for updating knowledge bases with disjunctive information. In this paper, we propose two different approaches to deal with this problem - one is called the minimal change with exceptions (MCE), the other is called the minimal change with maximal disjunctive inclusions (MCD). The first method is syntax-based, while the second is model-theoretic. We show that these two approaches are equivalent for propositional knowledge base updates, and the second method is also appropriate for first order knowledge base updates. We then prove that our new update approaches still satisfy the standard Katsuno and Mendelzon`s update postulates.

  13. Big bang nucleosynthesis: An update

    SciTech Connect

    Olive, Keith A.

    2013-07-23

    An update on the standard model of big bang nucleosynthesis (BBN) is presented. With the value of the baryon-tophoton ratio determined to high precision by WMAP, standard BBN is a parameter-free theory. In this context, the theoretical prediction for the abundances of D, {sup 4}He, and {sup 7}Li is discussed and compared to their observational determination. While concordance for D and {sup 4}He is satisfactory, the prediction for {sup 7}Li exceeds the observational determination by a factor of about four. Possible solutions to this problem are discussed.

  14. An update on Argonne's AWA

    SciTech Connect

    Rosing, M.; Chojnacki, E.; Gai, W.; Ho, C.; Konecny, R.; Mtingwa, S.; Norem, J.; Schoessow, P.; Simpson, J.

    1991-01-01

    The Argonne Wakefield Accelerator (AWA) is a new research facility which will possess unprecedented research capabilities for the study of wakefields and related areas requiring short, intense electron bunches. The AWA is designed to produce 100 nC, 14 ps (full width) electron bunches at rep rates up to 30 Hz. Phase-1 of the AWA, now under construction, will provide these pulses at 20 MeV for various experiments. Current designs, related research and development, and construction status are presented in this general overview and project update. 6 refs., 4 figs.

  15. Current Updates on Choanal Atresia

    PubMed Central

    Kwong, Kelvin M.

    2015-01-01

    Choanal atresia (CA) is a relatively uncommon but well-recognized condition characterized by the anatomical closure of the posterior choanae in the nasal cavity. Since the original description back in the early eighteenth century, there have been controversies regarding its exact pathogenesis, the optimal surgical approach, and the use of adjunct treatments such as post-surgical stenting and anti-neoplastic agents, despite of abundant literature available. The emergence and development of new technologies play a significant role in the management of this condition. This review provides a comprehensive clinical update on CA and identifies areas for future study based on the existing available literature. PMID:26106591

  16. Cerebral Palsy: A Dental Update

    PubMed Central

    Sehrawat, Nidhi; Bansal, Kalpana; Chopra, Radhika

    2014-01-01

    ABSTRACT Special and medically compromised patients present a unique population that challenges the dentist’s skill and knowledge. Providing oral care to people with cerebral palsy (CP) requires adaptation of the skills we use everyday. In fact, most people with mild or moderate forms of CP can be treated successfully in the general practice setting. This article is to review various dental considerations and management of a CP patient. How to cite this article: Sehrawat N, Marwaha M, Bansal K, Chopra R. Cerebral Palsy: A Dental Update. Int J Clin Pediatr Dent 2014;7(2):109-118. PMID:25356010

  17. ISS Update: Burning and Suppression of Solids

    NASA Video Gallery

    ISS Update Commentator Pat Ryan interviews Paul Ferkul, Principal Investigator for the Burning and Suppression of Solids (BASS) experiment, about performing combustion experiments in microgravity. ...

  18. Updating multipoint simulations using the ensemble Kalman filter

    NASA Astrophysics Data System (ADS)

    Hu, L. Y.; Zhao, Y.; Liu, Y.; Scheepens, C.; Bouchard, A.

    2013-02-01

    In the last two decades, the multipoint simulation (MPS) method has been developed and increasingly used for building complex geological facies models that are conditioned to geological and geophysical data. In the meantime, the ensemble Kalman filter (EnKF) approach has been developed and recognized as a promising way for assimilating dynamic production data into reservoir models. So far, the EnKF approach is proven efficient for updating continuous model parameters that have a linear statistical relation with the flow responses. It remains challenging to extend the EnKF approach to updating complex geological facies models generated by MPS, while preserving their geological and statistical consistency. In this paper, we introduce a new method for parameterizing geostatistical reservoir models generated by MPS. It is mathematically proven that updating these parameters during a history matching process does not compromise the hard data conditioning and the geological and statistical consistency of the reservoir model defined by the training image and other information including global facies proportions, trend maps etc. This method is an alternative to the gradual deformation method but has an enlarged search space for covering possible solutions. Based on the above parameterization, we present two algorithms of using EnKF approach to update multipoint simulations to dynamic data. We also present results of using the above methodology to condition a sector model of a fluvial reservoir to dynamic data.

  19. Optimal update with multiple out-of-sequence measurements

    NASA Astrophysics Data System (ADS)

    Zhang, Shuo; Bar-Shalom, Yaakov

    2011-06-01

    In multisensor target tracking systems receiving out-of-sequence measurements from local sensors is a common situation. In the last decade many algorithms have been proposed to update a target state with an OOSM optimally or suboptimally. However, what one faces in the real world is multiple OOSMs, which arrive at the fusion center in, generally, arbitrary orders, e.g., in succession or interleaved with in-sequence measurements. A straightforward approach to deal with this multi-OOSM problem is by sequentially applying a given OOSM algorithm; however, this simple solution does not guarantee optimal update under the multi-OOSM scenario. The present paper discusses the differences between the single-OOSM processing and the multi-OOSM processing, and presents the general solution to the multi-OOSM problem, called the complete in-sequence information (CISI) approach. Given an OOSM, in addition to updating the target state at the most recent time, the CISI approach also updates the states between the OOSM time and the most recent time, including the state at the OOSM time. Three novel CISI methods are developed in this paper: the information filter-equivalent measurement (IF-EqM) method, the CISI fixed-point smoothing (CISI-FPS) method and the CISI fixed-interval smoothing (CISI-FIS) method. Numerical examples are given to show the optimality of these CISI methods under various multi-OOSM scenarios.

  20. Development of a cyber-physical experimental platform for real-time dynamic model updating

    NASA Astrophysics Data System (ADS)

    Song, Wei; Dyke, Shirley

    2013-05-01

    Model updating procedures are traditionally performed off-line. With the significant recent advances in embedded systems and the related real-time computing capabilities, online or real-time, model updating can be performed to inform decision making and controller actions. The applications for real-time model updating are mainly in the areas of (i) condition diagnosis and prognosis of engineering systems; and (ii) control systems that benefit from accurate modeling of the system plant. Herein, the development of a cyber-physical real-time model updating experimental platform, including real-time computing environment, model updating algorithm, hardware architecture and testbed, is described. Results from two challenging experimental implementations are presented to illustrate the performance of this cyber-physical platform in achieving the goal of updating nonlinear systems in real-time. The experiments consider typical nonlinear engineering systems that exhibit hysteresis. Among the available algorithms capable of identification of such complex nonlinearities, the unscented Kalman filter (UKF) is selected for these experiments as an effective method to update nonlinear dynamic system models under realistic conditions. The implementation of the platform is discussed for successful completion of these experiments, including required timing constraints and overall evaluation of the system.

  1. Assessment of a method to detect signals for updating systematic reviews

    PubMed Central

    2014-01-01

    Background Systematic reviews are a cornerstone of evidence-based medicine but are useful only if up-to-date. Methods for detecting signals of when a systematic review needs updating have face validity, but no proposed method has had an assessment of predictive validity performed. Methods The AHRQ Comparative Effectiveness Review program had produced 13 comparative effectiveness reviews (CERs), a subcategory of systematic reviews, by 2009, 11 of which were assessed in 2009 using a surveillance system to determine the degree to which individual conclusions were out of date and to assign a priority for updating each report. Four CERs were judged to be a high priority for updating, four CERs were judged to be medium priority for updating, and three CERs were judged to be low priority for updating. AHRQ then commissioned full update reviews for 9 of these 11 CERs. Where possible, we matched the original conclusions with their corresponding conclusions in the update reports, and compared the congruence between these pairs with our original predictions about which conclusions in each CER remained valid. We then classified the concordance of each pair as good, fair, or poor. We also made a summary determination of the priority for updating each CER based on the actual changes in conclusions in the updated report, and compared these determinations with the earlier assessments of priority. Results The 9 CERs included 149 individual conclusions, 84% with matches in the update reports. Across reports, 83% of matched conclusions had good concordance, and 99% had good or fair concordance. The one instance of poor concordance was partially attributable to the publication of new evidence after the surveillance signal searches had been done. Both CERs originally judged as being low priority for updating had no substantive changes to their conclusions in the actual updated report. The agreement on overall priority for updating between prediction and actual changes to conclusions

  2. Risk stratification strategies for cancer-associated thrombosis: an update.

    PubMed

    Khorana, Alok A; McCrae, Keith R

    2014-05-01

    Rates of venous thromboembolism (VTE) vary substantially between cancer patients. Multiple clinical risk factors including primary site of cancer and systemic therapy, and biomarkers including leukocyte and platelet counts and tissue factor are associated with increased risk of VTE. However, risk cannot be reliably predicted based on single risk factors or biomarkers. New American Society of Clinical Guidelines recommend that patients with cancer be assessed for VTE risk at the time of chemotherapy initiation and periodically thereafter. This narrative review provides an update on risk stratification approaches including a validated Risk Score. Potential applications of risk assessment including targeted thromboprophylaxis are outlined. © 2014 Elsevier Ltd. All rights reserved. PMID:24862143

  3. Urticaria: an evidence-based update. Conference report.

    PubMed

    Alexandroff, A B; Harman, K E

    2010-08-01

    Summary Evidence-based update meetings are held annually by the Centre of Evidence Based Dermatology, University of Nottingham. Topics are chosen by delegates at the previous year's conference and in the past have included blistering disorders, psoriasis, hair disorders and skin cancers. Once the topic is identified, a trials database search is undertaken with the aim of including speakers who are actively involved in trials that address the subject in question. This year, the eighth Evidence Based Update meeting focused on urticaria and took place in Loughborough University on 14 May 2009. The latest data on the diagnosis and management of acute and chronic urticaria, including cold and solar urticaria, and the impact of food intolerance on chronic urticaria, were presented by an international panel of renowned speakers, who sometimes expressed different viewpoints. The highlights of the meeting included an informal atmosphere, an international perspective, and a practical question and answer session. Over 70% of the delegates stated that they would be changing their clinical practice following on from the meeting. The evidence-based update meeting in 2010 will be devoted to eczema. PMID:20666769

  4. Risk Assessment Update: Russian Segment

    NASA Technical Reports Server (NTRS)

    Christiansen, Eric; Lear, Dana; Hyde, James; Bjorkman, Michael; Hoffman, Kevin

    2012-01-01

    BUMPER-II version 1.95j source code was provided to RSC-E- and Khrunichev at January 2012 MMOD TIM in Moscow. MEMCxP and ORDEM 3.0 environments implemented as external data files. NASA provided a sample ORDEM 3.0 g."key" & "daf" environment file set for demonstration and benchmarking BUMPER -II v1.95j installation at the Jan-12 TIM. ORDEM 3.0 has been completed and is currently in beta testing. NASA will provide a preliminary set of ORDEM 3.0 ".key" & ".daf" environment files for the years 2012 through 2028. Bumper output files produced using the new ORDEM 3.0 data files are intended for internal use only, not for requirements verification. Output files will contain these words ORDEM FILE DESCRIPTION = PRELIMINARY VERSION: not for production. The projectile density term in many BUMPER-II ballistic limit equations will need to be updated. Cube demo scripts and output files delivered at the Jan-12 TIM have been updated for the new ORDEM 3.0 data files. Risk assessment results based on ORDEM 3.0 and MEM will be presented for the Russian Segment (RS) of ISS.

  5. State-level Greenhouse Gas Emission Factors for Electricity Generation, Updated

    EIA Publications

    2001-01-01

    To assist reporters in estimating emissions and emission reductions, The Energy Information Administration (EIA) has made available in the instructions to Forms EIA-1605 and EIA-1605EZ emission coefficients for most commonly used fossil fuels and electricity. These coefficients were based on 1992 emissions and generation data. In 1999, updated coefficients were prepared based on the most recent data (1998) then available; however, the updated coefficients were not included in the instructions for the 1999 data year. This year, they have been updated again, but based on three years worth of data (1997, 1998, and 1999) rather than a single year.

  6. Neoclassical Transport Including Collisional Nonlinearity

    SciTech Connect

    Candy, J.; Belli, E. A.

    2011-06-10

    In the standard {delta}f theory of neoclassical transport, the zeroth-order (Maxwellian) solution is obtained analytically via the solution of a nonlinear equation. The first-order correction {delta}f is subsequently computed as the solution of a linear, inhomogeneous equation that includes the linearized Fokker-Planck collision operator. This equation admits analytic solutions only in extreme asymptotic limits (banana, plateau, Pfirsch-Schlueter), and so must be solved numerically for realistic plasma parameters. Recently, numerical codes have appeared which attempt to compute the total distribution f more accurately than in the standard ordering by retaining some nonlinear terms related to finite-orbit width, while simultaneously reusing some form of the linearized collision operator. In this work we show that higher-order corrections to the distribution function may be unphysical if collisional nonlinearities are ignored.

  7. KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 update.

    PubMed

    2015-11-01

    The National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQI) has provided evidence-based guidelines for all stages of chronic kidney disease (CKD) and related complications since 1997. The 2015 update of the KDOQI Clinical Practice Guideline for Hemodialysis Adequacy is intended to assist practitioners caring for patients in preparation for and during hemodialysis. The literature reviewed for this update includes clinical trials and observational studies published between 2000 and March 2014. New topics include high-frequency hemodialysis and risks; prescription flexibility in initiation timing, frequency, duration, and ultrafiltration rate; and more emphasis on volume and blood pressure control. Appraisal of the quality of the evidence and the strength of recommendations followed the Grading of Recommendation Assessment, Development, and Evaluation (GRADE) approach. Limitations of the evidence are discussed and specific suggestions are provided for future research. PMID:26498416

  8. UCbase 2.0: ultraconserved sequences database (2014 update)

    PubMed Central

    Lomonaco, Vincenzo; Martoglia, Riccardo; Mandreoli, Federica; Anderlucci, Laura; Emmett, Warren; Bicciato, Silvio; Taccioli, Cristian

    2014-01-01

    UCbase 2.0 (http://ucbase.unimore.it) is an update, extension and evolution of UCbase, a Web tool dedicated to the analysis of ultraconserved sequences (UCRs). UCRs are 481 sequences >200 bases sharing 100% identity among human, mouse and rat genomes. They are frequently located in genomic regions known to be involved in cancer or differentially expressed in human leukemias and carcinomas. UCbase 2.0 is a platform-independent Web resource that includes the updated version of the human genome annotation (hg19), information linking disorders to chromosomal coordinates based on the Systematized Nomenclature of Medicine classification, a query tool to search for Single Nucleotide Polymorphisms (SNPs) and a new text box to directly interrogate the database using a MySQL interface. To facilitate the interactive visual interpretation of UCR chromosomal positioning, UCbase 2.0 now includes a graph visualization interface directly linked to UCSC genome browser. Database URL: http://ucbase.unimore.it PMID:24951797

  9. UCbase 2.0: ultraconserved sequences database (2014 update).

    PubMed

    Lomonaco, Vincenzo; Martoglia, Riccardo; Mandreoli, Federica; Anderlucci, Laura; Emmett, Warren; Bicciato, Silvio; Taccioli, Cristian

    2014-01-01

    UCbase 2.0 (http://ucbase.unimore.it) is an update, extension and evolution of UCbase, a Web tool dedicated to the analysis of ultraconserved sequences (UCRs). UCRs are 481 sequences >200 bases sharing 100% identity among human, mouse and rat genomes. They are frequently located in genomic regions known to be involved in cancer or differentially expressed in human leukemias and carcinomas. UCbase 2.0 is a platform-independent Web resource that includes the updated version of the human genome annotation (hg19), information linking disorders to chromosomal coordinates based on the Systematized Nomenclature of Medicine classification, a query tool to search for Single Nucleotide Polymorphisms (SNPs) and a new text box to directly interrogate the database using a MySQL interface. To facilitate the interactive visual interpretation of UCR chromosomal positioning, UCbase 2.0 now includes a graph visualization interface directly linked to UCSC genome browser. Database URL: http://ucbase.unimore.it. PMID:24951797

  10. Clinical practice guideline (update): Adult Sinusitis Executive Summary.

    PubMed

    Rosenfeld, Richard M; Piccirillo, Jay F; Chandrasekhar, Sujana S; Brook, Itzhak; Kumar, Kaparaboyna Ashok; Kramper, Maggie; Orlandi, Richard R; Palmer, James N; Patel, Zara M; Peters, Anju; Walsh, Sandra A; Corrigan, Maureen D

    2015-04-01

    The American Academy of Otolaryngology-Head and Neck Surgery Foundation has published a supplement to this issue featuring the updated "Clinical Practice Guideline: Adult Sinusitis" as a supplement to Otolaryngology-Head and Neck Surgery. To assist in implementing the guideline recommendations, this article summarizes the rationale, purpose, and key action statements. The 14 developed recommendations address diagnostic accuracy for adult rhinosinusitis, the appropriate use of ancillary tests to confirm diagnosis and guide management (including radiography, nasal endoscopy, computed tomography, and testing for allergy and immune function), and the judicious use of systemic and topical therapy. Emphasis was also placed on identifying multiple chronic conditions that would modify management of rhinosinusitis, including asthma, cystic fibrosis, immunocompromised state, and ciliary dyskinesia. An updated guideline is needed as a result of new clinical trials, new systematic reviews, and the lack of consumer participation in the initial guideline development group. PMID:25833927

  11. Background Information Document for Updating AP42 Section 2.4 for Estimating Emissions from Municipal Solid Waste Landfills

    EPA Science Inventory

    This revised draft document was prepared for U.S. EPA's Office of Research and Development, and describes the data analysis undertaken to update the Municipal Solid Waste (MSW) Landfill section of AP-42. This 2008 update includes the addition of data from 62 landfill gas emission...

  12. Considerations from the risk of bias perspective for updating Cochrane reviews.

    PubMed

    Mayhew, Alain D; Kabir, Monisha; Ansari, Mohammed T

    2015-01-01

    Authors of Cochrane reviews are expected to update their reviews every 2 years. The updating process helps to ensure that reviews are current and include recent evidence. However, the updating process is time-consuming for authors, particularly when Cochrane methods evolve and authors are required to revisit some of the originally included studies.The Cochrane Collaboration's 'Risk of bias' tool is a mandatory component of Cochrane reviews, providing an assessment of the potential biases of included studies. The tool has been modified most recently in 2011, and the expectation is that new versions will continue to be produced and utilised in all Cochrane reviews. In this commentary we discuss, in the context of updating scenarios that are likely to be encountered, the potential options systematic review authors may have recourse to when the Cochrane Collaboration's 'Risk of bias' tool has been modified between the original review and its update. We recommend that authors who are updating reviews should revise their original assessments of included studies using the most recent version of the risk of bias tool. Despite the increased workload, use of the most recent version of the tool facilitates consistency of methods and reporting both across and within reviews, and ensures currency to the methodological rigour. PMID:26445323

  13. AYP Results for 2010-11--May 2012 Update

    ERIC Educational Resources Information Center

    Usher, Alexandra

    2012-01-01

    This report updates the December, 2011 report "AYP Results for 2010-11" to include AYP data from school year 2010-11 for New York State. Several numbers throughout the report have changed as a result of the new data from New York. Most notably, the estimated percentage of all public schools in the nation that did not make AYP for 2011 has been…

  14. Breast cancer risk calculator updated for Asian-Americans

    Cancer.gov

    Researchers have developed a more accurate method for estimating breast cancer risk for Asian and Pacific Islander American (APA) women. Most current risk estimates rely on data from non-Hispanic white women, but researchers have now come up with a statistical model that more specifically assesses risk for American women who identify themselves as Chinese, Japanese, Filipino, Hawaiian, other Pacific Islander, or other Asian. NCI’s Breast Cancer Risk Assessment Tool (BCRAT) has now been updated to include the new model.

  15. Diabetes and Glucose Metabolism in Thalassemia Major: An Update.

    PubMed

    De Sanctis, Vincenzo; Soliman, Ashraf T; Elsedfy, Heba; Pepe, Alessia; Kattamis, Christos; El Kholy, Mohamed; Yassin, Mohamed

    2016-04-01

    In patients with TM, uncontrolled iron overload has serious clinical consequences with considerable morbidity and mortality. Complications include liver damage, cardiac disease and endocrine dysfunction. Diabetes is an important complication of TM. The mechanisms of abnormal glucose homeostasis are complex and multifactorial. This review updates the current knowledge about glycemic abnormalities in TM patients and directs the attention to an early diagnosis and proper management. PMID:26697756

  16. Colorectal Cancer in African Americans: An Update

    PubMed Central

    Williams, Renee; White, Pascale; Nieto, Jose; Vieira, Dorice; Francois, Fritz; Hamilton, Frank

    2016-01-01

    This review is an update to the American College of Gastroenterology (ACG) Committee on Minority Affairs and Cultural Diversity's paper on colorectal cancer (CRC) in African Americans published in 2005. Over the past 10 years, the incidence and mortality rates of CRC in the United States has steadily declined. However, reductions have been strikingly much slower among African Americans who continue to have the highest rate of mortality and lowest survival when compared with all other racial groups. The reasons for the health disparities are multifactorial and encompass physician and patient barriers. Patient factors that contribute to disparities include poor knowledge of benefits of CRC screening, limited access to health care, insurance status along with fear and anxiety. Physician factors include lack of knowledge of screening guidelines along with disparate recommendations for screening. Earlier screening has been recommended as an effective strategy to decrease observed disparities; currently the ACG and American Society of Gastrointestinal Endoscopists recommend CRC screening in African Americans to begin at age 45. Despite the decline in CRC deaths in all racial and ethnic groups, there still exists a significant burden of CRC in African Americans, thus other strategies including educational outreach for health care providers and patients and the utilization of patient navigation systems emphasizing the importance of screening are necessary. These strategies have been piloted in both local communities and Statewide resulting in notable significant decreases in observed disparities. PMID:27467183

  17. Colorectal Cancer in African Americans: An Update.

    PubMed

    Williams, Renee; White, Pascale; Nieto, Jose; Vieira, Dorice; Francois, Fritz; Hamilton, Frank

    2016-01-01

    This review is an update to the American College of Gastroenterology (ACG) Committee on Minority Affairs and Cultural Diversity's paper on colorectal cancer (CRC) in African Americans published in 2005. Over the past 10 years, the incidence and mortality rates of CRC in the United States has steadily declined. However, reductions have been strikingly much slower among African Americans who continue to have the highest rate of mortality and lowest survival when compared with all other racial groups. The reasons for the health disparities are multifactorial and encompass physician and patient barriers. Patient factors that contribute to disparities include poor knowledge of benefits of CRC screening, limited access to health care, insurance status along with fear and anxiety. Physician factors include lack of knowledge of screening guidelines along with disparate recommendations for screening. Earlier screening has been recommended as an effective strategy to decrease observed disparities; currently the ACG and American Society of Gastrointestinal Endoscopists recommend CRC screening in African Americans to begin at age 45. Despite the decline in CRC deaths in all racial and ethnic groups, there still exists a significant burden of CRC in African Americans, thus other strategies including educational outreach for health care providers and patients and the utilization of patient navigation systems emphasizing the importance of screening are necessary. These strategies have been piloted in both local communities and Statewide resulting in notable significant decreases in observed disparities. PMID:27467183

  18. The UCSC Genome Browser database: 2014 update

    PubMed Central

    Karolchik, Donna; Barber, Galt P.; Casper, Jonathan; Clawson, Hiram; Cline, Melissa S.; Diekhans, Mark; Dreszer, Timothy R.; Fujita, Pauline A.; Guruvadoo, Luvina; Haeussler, Maximilian; Harte, Rachel A.; Heitner, Steve; Hinrichs, Angie S.; Learned, Katrina; Lee, Brian T.; Li, Chin H.; Raney, Brian J.; Rhead, Brooke; Rosenbloom, Kate R.; Sloan, Cricket A.; Speir, Matthew L.; Zweig, Ann S.; Haussler, David; Kuhn, Robert M.; Kent, W. James

    2014-01-01

    The University of California Santa Cruz (UCSC) Genome Browser (http://genome.ucsc.edu) offers online public access to a growing database of genomic sequence and annotations for a large collection of organisms, primarily vertebrates, with an emphasis on the human and mouse genomes. The Browser’s web-based tools provide an integrated environment for visualizing, comparing, analysing and sharing both publicly available and user-generated genomic data sets. As of September 2013, the database contained genomic sequence and a basic set of annotation ‘tracks’ for ∼90 organisms. Significant new annotations include a 60-species multiple alignment conservation track on the mouse, updated UCSC Genes tracks for human and mouse, and several new sets of variation and ENCODE data. New software tools include a Variant Annotation Integrator that returns predicted functional effects of a set of variants uploaded as a custom track, an extension to UCSC Genes that displays haplotype alleles for protein-coding genes and an expansion of data hubs that includes the capability to display remotely hosted user-provided assembly sequence in addition to annotation data. To improve European access, we have added a Genome Browser mirror (http://genome-euro.ucsc.edu) hosted at Bielefeld University in Germany. PMID:24270787

  19. Fast Updating National Geo-Spatial Databases with High Resolution Imagery: China's Methodology and Experience

    NASA Astrophysics Data System (ADS)

    Chen, J.; Wang, D.; Zhao, R. L.; Zhang, H.; Liao, A.; Jiu, J.

    2014-04-01

    Geospatial databases are irreplaceable national treasure of immense importance. Their up-to-dateness referring to its consistency with respect to the real world plays a critical role in its value and applications. The continuous updating of map databases at 1:50,000 scales is a massive and difficult task for larger countries of the size of more than several million's kilometer squares. This paper presents the research and technological development to support the national map updating at 1:50,000 scales in China, including the development of updating models and methods, production tools and systems for large-scale and rapid updating, as well as the design and implementation of the continuous updating workflow. The use of many data sources and the integration of these data to form a high accuracy, quality checked product were required. It had in turn required up to date techniques of image matching, semantic integration, generalization, data base management and conflict resolution. Design and develop specific software tools and packages to support the large-scale updating production with high resolution imagery and large-scale data generalization, such as map generalization, GIS-supported change interpretation from imagery, DEM interpolation, image matching-based orthophoto generation, data control at different levels. A national 1:50,000 databases updating strategy and its production workflow were designed, including a full coverage updating pattern characterized by all element topographic data modeling, change detection in all related areas, and whole process data quality controlling, a series of technical production specifications, and a network of updating production units in different geographic places in the country.

  20. Census in Schools Educator Update, November 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) New Web Site for the…

  1. Census in Schools Educator Update, May 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census: The…

  2. Census in Schools Educator Update, February 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census Video: A…

  3. 40 CFR 55.12 - Consistency updates.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 5 2011-07-01 2011-07-01 false Consistency updates. 55.12 Section 55.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) OUTER CONTINENTAL SHELF AIR REGULATIONS § 55.12 Consistency updates. (a) The Administrator will...

  4. Spatial Updating of Environments Described in Texts

    ERIC Educational Resources Information Center

    Avraamides, Marios N.

    2003-01-01

    People update egocentric spatial relations in an effortless and on-line manner when they move in the environment, but not when they only imagine themselves moving. In contrast to previous studies, the present experiments examined egocentric updating with spatial scenes that were encoded linguistically instead of perceived directly. Experiment 1…

  5. 34 CFR 668.55 - Updating information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Updating information. 668.55 Section 668.55 Education... Information § 668.55 Updating information. (a)(1) Unless the provisions of paragraph (a)(2) or (a)(3) of this... applicant to verify the information contained in his or her application for assistance in an award year...

  6. 34 CFR 668.55 - Updating information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false Updating information. 668.55 Section 668.55 Education... Information § 668.55 Updating information. (a)(1) Unless the provisions of paragraph (a)(2) or (a)(3) of this... applicant to verify the information contained in his or her application for assistance in an award year...

  7. Control of Interference during Working Memory Updating

    ERIC Educational Resources Information Center

    Szmalec, Arnaud; Verbruggen, Frederick; Vandierendonck, Andre; Kemps, Eva

    2011-01-01

    The current study examined the nature of the processes underlying working memory updating. In 4 experiments using the n-back paradigm, the authors demonstrate that continuous updating of items in working memory prevents strong binding of those items to their contexts in working memory, and hence leads to an increased susceptibility to proactive…

  8. 40 CFR 68.190 - Updates.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 16 2012-07-01 2012-07-01 false Updates. 68.190 Section 68.190 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.190 Updates. (a) The owner or operator...

  9. Tech Plan Update Electronic Forms Preview.

    ERIC Educational Resources Information Center

    Massachusetts State Dept. of Education, Malden.

    This packet of "Tech Plan Update" Preview forms is provided by the Massachusetts Department of Education for planning purposes for the July 1, 2000 to June 30, 2001 fiscal year, prior to submitting "Tech Plan Update" electronic forms online. The first section, Local Technology Plan Data Collection Form, is divided by benchmarks, as follows:…

  10. 77 FR 41258 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... Proposed FOIA Fee Schedule, 77 FR 32433. No comments were received in response to that notice, and the... Schedule Update went into effect on July 29, 2011. 76 FR 43819. Board Action Accordingly, the Board issues... SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety...

  11. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  12. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  13. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  14. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  15. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  16. Census in Schools Educator Update, April 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census; (2)…

  17. Census in Schools Educator Update, June 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census; (2)…

  18. Better Plants Progress Update Fall 2013

    SciTech Connect

    none,

    2013-09-23

    This Progress Update summarizes the significant energy saving achievements and cumulative cost savings made by these industry leaders from 2010-2012. The update also shares the plans and priorities over the next year for the Better Plants Program to continue to advance energy efficiency in the industrial sector.

  19. 1 CFR 8.3 - Periodic updating.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Periodic updating. 8.3 Section 8.3 General... the intent and purpose of the Administrative Committee as stated in § 8.1. (b) Staggered publication... before the “As of” date. Thus, each title updated as of July 1 each year will reflect all...

  20. 1 CFR 8.3 - Periodic updating.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Periodic updating. 8.3 Section 8.3 General... the intent and purpose of the Administrative Committee as stated in § 8.1. (b) Staggered publication... before the “As of” date. Thus, each title updated as of July 1 each year will reflect all...