Science.gov

Sample records for 6 7 8

  1. RDamage 6, 7, 8 & 9 Cassettes

    SciTech Connect

    Griego, Jeffrey R; Kaul, Ann

    2012-06-08

    The RDamage series of ten experiments is part of a long-term collaboration with RFNC/VNIIEF in pulsed power technology. These experiments use a cylindrical configuration to study spallation damage, which allows for a natural recollection of the damaged material under proper driving conditions and post-shot collection of the damaged target material for subsequent metallographic analysis. Dynamic insitu experimental velocimetry diagnostics are also employed. LANL is responsible for the design of the experimental load and velocimetry system. VNIIEF is responsible for the design and construction of the driving explosive magnetic generator. In the RDamage-0, -1 and -2 experiments, data was collected about failure initiation of a well-characterized material (aluminum) in a cylindrical geometry. The RDamage-3, -4 and -5 experiments produced data on the behavior of material recollected after damage from pressures in the damage initiation regime. Data on the behavior of material recollected after complete failure was collected in the RDamage-6, -7, -8 and -9 experiments. This presentation shows the evolution of the load assembly through the experimental series.

  2. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  3. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  4. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  5. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  6. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  7. 12. VIEW OF PUMPS NO. 6, 8, AND 7 (L ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW OF PUMPS NO. 6, 8, AND 7 (L TO R) WITH THEIR CANVAS COVERS, LOOKING NORTHEAST. NOTE CONCRETE CONSTRUCTION. THE FOUR LIGHT WINDOWS AND THE STEEL EAM FOR THE 10-TON HAND OPERATED TRAVELING CRANE. - Wyoming Valley Flood Control System, Woodward Pumping Station, East of Toby Creek crossing by Erie-Lackawanna Railroad, Edwardsville, Luzerne County, PA

  8. Identification of 5,6,7,8-tetrahydropterin and 5,6,7,8-tetrahydrobiopterin in Drosophila melanogaster.

    PubMed

    Guillamón, J J; Ferré, J

    1988-04-15

    Using reversed-phase high-performance liquid chromatography with electrochemical detection we have demonstrated the occurrence of 5,6,7,8-tetrahydropterin and 5,6,7,8-tetrahydrobiopterin in Drosophila melanogaster. The former is the first time that has been detected in vivo. The identification has been based on the retention times, hydrodinamic voltagrams and the differential concentration in three strains of Drosophila melanogaster. Compared to the wild type, the Punch2 mutant has diminished levels of both pteridines, whereas Henna-recessive3 lacks completely tetrahydropterin and has increased levels of tetrahydrobiopterin, as expected according to their biochemical lesions.

  9. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  10. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  11. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  12. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  13. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  14. Curriculum Manual: 6th, 7th, 8th Grades.

    ERIC Educational Resources Information Center

    Snell, Ednell M.; Snapp, Betty Lou

    This home economics curriculum for the middle school (grades 6-8) is designed to assist students in developing self-concept, making decisions, and developing basic skills. Written by a group of home economics teachers, this curriculum contains nine learning packages on the following topics: (1) consumer management; (2) decision management; (3)…

  15. Genotoxicity tests with 6-acetyl-1,1,2,4,4,7-hexamethyltetraline and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyr an.

    PubMed

    Api, A M; San, R H

    1999-10-29

    6-Acetyl-1,1,2,4,4,7-hexamethyltetraline (AHTN) and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-ben zopyran (HHCB), synthetic fragrance ingredients, were evaluated for potential genotoxicity in a battery of short-term tests. Salmonella typhimurium/Escherichia coli plate incorporation and liquid preincubation assays were conducted on AHTN using tester strains TA97, TA98, TA100, TA102, TA1535, TA1537 and WP2 uvrA +/- S9 activation at doses from 8 to 5000 micrograms/plate. The plate incorporation mutagenicity assay was conducted on HHCB using tester strains TA98, TA100, TA1535, TA1537, TA1538 and WP2 uvrA +/- S9 activation at doses from 10 to 5000 micrograms/plate. An in vitro cytogenetics assay in Chinese hamster ovary (CHO) cells was conducted with AHTN and HHCB at three concentrations each with +/- S9 activation. In the non-activated study, the exposure/harvest periods were 4/20-, 20/20- and 44/44-h. In the S9 activated study, the exposure/harvest periods were 4/20- and 4/44-h. In vitro unscheduled DNA synthesis (UDS) assays were conducted in primary rat hepatocytes at concentrations between 0.15 and 50 micrograms/ml for AHTN and HHCB. In vivo mouse micronucleus assays were conducted with high doses of 1600 mg AHTN/kg and of 1500 mg HHCB/kg in corn oil. No positive responses were observed in any of the tests with HHCB. With AHTN, no positive responses were observed except for cells with structural aberrations in the in vitro cytogenetics assay in CHO cells with S9 activation at the treatment/harvest time of 4/20 h. In initial studies with AHTN, the high dose of 7.8 micrograms/ml showed 0.5% aberrant cells, with the mitotic index at 41% relative to vehicle control and cell growth inhibition in the range of 25-50%. Thus the genotoxicity findings with AHTN were limited to this one positive response; all other genotoxicity tests with AHTN were considered as negative. In particular, the negative finding in the in vivo assay supports AHTN as not likely

  16. Uptake and biotransformation of 6,7-dimethylquinoline and 6,8-dimethylquinoline by rainbow trout (Salmo gairdneri).

    PubMed

    Birkholz, D A; Coutts, R T; Hrudey, S E

    1989-07-01

    1. 6,7-Dimethylquinoline (6,7-DMQ) is readily taken up by rainbow trout and bioconcentrated in tissue after exposure to ca 1 mg/l for 7.5 h. Mean bioconcentration factors (from water) were 21, 18, 6 and 14 for bile, liver, muscle and carcass respectively. Mean tissue concentrations after 69-96 h depuration were ND, ND, 0.54 and 0.48 micrograms/g for bile, liver, muscle and carcass respectively. 2. Major metabolites, following exposure to 6,7-DMQ, were conjugates (glucuronide or sulphate) of 7-hydroxymethyl-6-methylquinoline and 6-hydroxymethyl-7-methylquinoline. Mean concentration of metabolites in the bile were 500 micrograms/g after 7.5 h exposure to ca 1 mg/l and 1367 micrograms/g after 9.5 h exposure to ca 1 mg/l and 69 h depuration. 3. 6,8-Dimethylquinoline (6,8-DMQ) is also readily bioconcentrated in fish tissue after exposure to ca 1 mg/l. Mean bioconcentration factors (from water) were 23, 20, 13 and 25 for bile, liver, muscle and carcass respectively. Mean tissue concentrations after 7 h exposure to ca 1 mg/l and 63 h depuration were 4.0, 0.67, 0.49, and 3.2 micrograms/g respectively for bile, liver, muscle and carcass. 4. Major metabolites, following exposure to 6,8-DMQ were conjugates (glucuronide or sulphate) of 6,8-dimethyl-5-hydroxyquinoline, 6,8-dimethyl-7-hydroxyquinoline, 6,8-dimethyl-3-hydroxyquinoline and 6-hydroxymethyl-8-methylquinoline. Mean concentration of metabolites in the bile were 1278 micrograms/g after exposure to ca 1 mg/l for 8 h and 1031 micrograms/g after exposure to ca 1 mg/l for 7 h and 63 h depuration.

  17. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties

    SciTech Connect

    Shi, Genbin; Shaw, Gary; Liang, Yu-He; Subburaman, Priadarsini; Li, Yue; Wu, Yan; Yan, Honggao; Ji, Xinhua

    2012-07-11

    6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), a key enzyme in the folate biosynthetic pathway, catalyzes the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin. The enzyme is essential for microorganisms, is absent from humans, and is not the target for any existing antibiotics. Therefore, HPPK is an attractive target for developing novel antimicrobial agents. Previously, we characterized the reaction trajectory of HPPK-catalyzed pyrophosphoryl transfer and synthesized a series of bisubstrate analog inhibitors of the enzyme by linking 6-hydroxymethylpterin to adenosine through 2, 3, or 4 phosphate groups. Here, we report a new generation of bisubstrate analog inhibitors. To improve protein binding and linker properties of such inhibitors, we have replaced the pterin moiety with 7,7-dimethyl-7,8-dihydropterin and the phosphate bridge with a piperidine linked thioether. We have synthesized the new inhibitors, measured their K{sub d} and IC{sub 50} values, determined their crystal structures in complex with HPPK, and established their structure-activity relationship. 6-Carboxylic acid ethyl ester-7,7-dimethyl-7,8-dihydropterin, a novel intermediate that we developed recently for easy derivatization at position 6 of 7,7-dimethyl-7,8-dihydropterin, offers a much high yield for the synthesis of bisubstrate analogs than that of previously established procedure.

  18. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties

    PubMed Central

    Shi, Genbin; Shaw, Gary; Liang, Yu-He; Subburaman, Priadarsini; Li, Yue; Wu, Yan; Yan, Honggao; Ji, Xinhua

    2011-01-01

    6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), a key enzyme in the folate biosynthetic pathway, catalyzes the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin. The enzyme is essential for microorganisms, is absent from humans, and is not the target for any existing antibiotics. Therefore, HPPK is an attractive target for developing novel antimicrobial agents. Previously, we characterized the reaction trajectory of HPPK-catalyzed pyrophosphoryl transfer and synthesized a series of bisubstrate analog inhibitors of the enzyme by linking 6-hydroxymethylpterin to adenosine through 2, 3, or 4 phosphate groups. Here, we report a new generation of bisubstrate analog inhibitors. To improve protein binding and linker properties of such inhibitors, we have replaced the pterin moiety with 7,7-dimethyl-7,8-dihydropterin and the phosphate bridge with a piperidine linked thioether. We have synthesized the new inhibitors, measured their Kd and IC50 values, determined their crystal structures in complex with HPPK, and established their structure-activity relationship. 6-Carboxylic acid ethyl ester-7,7-dimethyl-7,8-dihydropterin, a novel intermediate that we developed recently for easy derivatization at position 6 of 7,7-dimethyl-7,8-dihydropterin, offers a much high yield for the synthesis of bisubstrate analogs than that of previously established procedure. PMID:22169600

  19. 7 CFR 319.8-6 - Cottonseed cake and cottonseed meal.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 5 2011-01-01 2011-01-01 false Cottonseed cake and cottonseed meal. 319.8-6 Section... of Importation and Entry of Cotton and Covers § 319.8-6 Cottonseed cake and cottonseed meal. Entry of cottonseed cake and cottonseed meal will be authorized through any port at which the services of an...

  20. 7 CFR 319.8-6 - Cottonseed cake and cottonseed meal.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Cottonseed cake and cottonseed meal. 319.8-6 Section... of Importation and Entry of Cotton and Covers § 319.8-6 Cottonseed cake and cottonseed meal. Entry of cottonseed cake and cottonseed meal will be authorized through any port at which the services of an...

  1. 7 CFR 319.8-6 - Cottonseed cake and cottonseed meal.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 5 2013-01-01 2013-01-01 false Cottonseed cake and cottonseed meal. 319.8-6 Section... of Importation and Entry of Cotton and Covers § 319.8-6 Cottonseed cake and cottonseed meal. Entry of cottonseed cake and cottonseed meal will be authorized through any port at which the services of an...

  2. 7 CFR 319.8-6 - Cottonseed cake and cottonseed meal.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 5 2014-01-01 2014-01-01 false Cottonseed cake and cottonseed meal. 319.8-6 Section... of Importation and Entry of Cotton and Covers § 319.8-6 Cottonseed cake and cottonseed meal. Entry of cottonseed cake and cottonseed meal will be authorized through any port at which the services of an...

  3. 7 CFR 319.8-6 - Cottonseed cake and cottonseed meal.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Cottonseed cake and cottonseed meal. 319.8-6 Section... of Importation and Entry of Cotton and Covers § 319.8-6 Cottonseed cake and cottonseed meal. Entry of cottonseed cake and cottonseed meal will be authorized through any port at which the services of an...

  4. 8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition of classification. As a condition of classification and...

  5. 8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition of classification. As a condition of classification and...

  6. 8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition of classification. As a condition of classification and...

  7. 5. CONTEXTUAL VIEW WEST OF (LEFT TO RIGHT) FEATURES 7,6,2,8, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. CONTEXTUAL VIEW WEST OF (LEFT TO RIGHT) FEATURES 7,6,2,8, AND 1 WITHIN MILL COMPLEX. - Juniata Mill Complex, 22.5 miles Southwest of Hawthorne, between Aurora Crater & Aurora Peak, Hawthorne, Mineral County, NV

  8. Herpesviruses 6, 7 and 8 in HIV- and non-HIV-associated periodontitis.

    PubMed

    Mardirossian, A; Contreras, A; Navazesh, M; Nowzari, H; Slots, J

    2000-10-01

    Human herpesviruses, especially cytomegalovirus and Epstein Barr virus type-1, occur with higher frequency in subgingival specimens from periodontitis lesions than from healthy/gingivitis sites. Little or no information is available on the relationship between herpesvirus 6 (HHV-6), herpesvirus 7 (HHV-7) and herpesvirus 8 (HHV-8) and periodontal disease. This study determined the periodontal occurrence of HHV-6, HHV-7 and HHV-8 in 21 HIV-seropositive and 14 HIV-negative adults affected by periodontitis. Gingival biopsy specimens and paper-point samples of subgingival plaque were collected from sites showing 5 mm or more in probing depth. Nested polymerase chain reaction methodology was employed in herpesvirus identification. In the HIV-seropositive periodontitis group, 90% of gingival biopsies and 62% of subgingival plaque samples revealed at least one of the test viruses. HHV-6 occurred in 71%, HHV-7 in 67% and HHV-8 in 24% of gingival biopsies. In the HIV-negative adult periodontitis group, 43% of gingival biopsies showed at least 1 of the test viruses, with HHV-6 present in 21% and H HV-7 in 29% of gingival biopsies and with no detection of HHV-8. The combined occurrence of the 3 test herpesviruses was significantly higher in HIV-seropositive than in HIV-negative adult periodontitis patients (p = 0.008). The human periodontium might constitute a site of infection or reservoir for HHV-6, -7, -8.

  9. 8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition... section 101(a)(15)(S) of the Act, nonimmigrants in S classification must have executed Form I-854, Part...

  10. 8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition... section 101(a)(15)(S) of the Act, nonimmigrants in S classification must have executed Form I-854, Part...

  11. 8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition... section 101(a)(15)(S) of the Act, nonimmigrants in S classification must have executed Form I-854, Part...

  12. Biosynthesis of riboflavin. Enzymatic formation of 6,7-dimethyl-8-ribityllumazine from pentose phosphates.

    PubMed

    Nielsen, P; Neuberger, G; Fujii, I; Bown, D H; Keller, P J; Floss, H G; Bacher, A

    1986-03-15

    The xylene ring of riboflavin originates by dismutation of the precursor, 6,7-dimethyl-8-ribityllumazine. The formation of the latter compound requires a 4-carbon unit as the precursor of carbon atoms 6 alpha, 6, 7, and 7 alpha of the pyrazine ring. The formation of riboflavin from GTP and ribose phosphate by cell extract from Candida guilliermondii has been observed by Logvinenko et al. (Logvinenko, E. M., Shavlovsky, G. M., Zakal'sky, A. E., and Zakhodylo, I. V. (1982) Biokhimiya 47, 931-936). We have studied this enzyme reaction in closer detail using carbohydrate phosphates as substrates and synthetic 5-amino-6-ribitylamino-2,4-(1H,3H)-pyrimidinedione or its 5'-phosphate as cosubstrates. Several pentose phosphates and pentulose phosphates can serve as substrate for the formation of riboflavin with similar efficiency. The reaction requires Mg2+. Various samples of ribulose phosphate labeled with 14C or 13C have been prepared and used as enzyme substrates. Radioactivity was efficiently incorporated into riboflavin from [1-14C]ribulose phosphate, [3,5-14C]ribulose phosphate, and [5-14C]ribulose phosphate, but not from [4-14C]ribulose phosphate. Label from [1-13C]ribose 5-phosphate was incorporated into C6 and C8 alpha of riboflavin. [2,3,5-13C]Ribose 5-phosphate yielded riboflavin containing two contiguously labeled segments of three carbon atoms, namely 5a, 9a, 9 and 8, 7, 7 alpha. 5-Amino-6-[1'-14C] ribitylamino-2,4 (1H,3H)-pyrimidinedione transferred radioactivity exclusively to the ribityl side chain of riboflavin in the enzymatic reaction. It follows that the 4-carbon unit used for the biosynthesis of 6,7-dimethyl-8-ribityllumazine consists of the pentose carbon atoms 1, 2, 3, and 5 in agreement with earlier in vivo studies. PMID:3949782

  13. One-Dimensional σ-MODELS with N = 5, 6, 7, 8 Off-Shell Supersymmetries

    NASA Astrophysics Data System (ADS)

    Gonzales, M.; Rojas, M.; Toppan, F.

    We computed the actions for the one-dimensional (1D) N = 5 σ-models with respect to the two inequivalent (2, 8, 6) multiplets. Four supersymmetry generators are manifest, while the constraint originated by imposing the fifth supersymmetry automatically induces a full N = 8 off-shell invariance. The resulting action coincides in the two cases and corresponds to a conformally flat 2D target satisfying a special geometry of rigid type. To obtain these results we developed a computational method (for Maple 11) which does not require the notion of superfields and is instead based on the nowadays available list of the inequivalent representations of the 1D N-extended supersymmetry. Its application to systematically analyze the σ-models off-shell invariant actions for the remaining N = 5, 6, 7, 8 (k, 8, 8-k) multiplets, as well as for the N>8 representations, only requires more cumbersome computations.

  14. Polymorphisms of KAP6, KAP7, and KAP8 genes in four Chinese sheep breeds.

    PubMed

    Liu, Y X; Shi, G Q; Wang, H X; Wan, P C; Tang, H; Yang, H; Guan, F

    2014-04-30

    High glycine-tyrosine proteins (HGTPs), also known as keratin-associated proteins (KAPs), play a key role in the major structures and mechanical properties of wool fiber. Sheep HGTPs consist of three multigene families: KAP6, KAP7, and KAP8 genes. Polymorphisms of these three genes have been proposed to have important effects on wool fiber traits. The aim of the present study was to identify polymorphisms of the KAP6, KAP7, and KAP8 genes in four sheep breeds, including Chinese Merino superfine wool sheep, Hu sheep, a Merino x Hu crossed breed, and Romney sheep. Polymerase chain reaction (PCR) product direct sequencing, PCR-single-strand conformation polymorphism, and cloned sequencing methods were used to find genetic variation and identify polymorphisms in these genes. The Mutation Surveyor v3.97 software was used to analyze the sequences. These methods revealed six different sequences of the KAP6 gene, two different sequences of the KAP7 gene, and five different sequences of the KAP8 gene. Accordingly, three (with frequencies>1%) single nucleotide polymorphisms (SNPs) of the KAP6 gene, one SNP of the KAP7 gene, and five SNPs of the KAP8 gene were detected. Interestingly, some of these sequences were present in only certain sheep breeds, thereby suggesting that these special allele sequences could be used as candidate genes of wool characteristics in further studies.

  15. Evaluation of the oral subchronic toxicity of HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2 -benzopyran) in the rat.

    PubMed

    Api, A M; Ford, R A

    1999-12-20

    1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-ben zopyran (HHCB) is used in a wide variety of fragrances in consumer products. Because of the widespread exposure to this material, a 90-day oral feeding study in accordance with OECD guidelines No. 408, with 4-week recovery periods for selected rats, was conducted. HHCB was added to the diet of rats at levels calculated to result in mean daily doses of 5, 15, 50 or 150 mg HHCB/kg. On completion of the treatment period, three males and three females from the high dose and control groups were maintained for a treatment free period of 4 weeks. No adverse effects were revealed from clinical examination or following extensive histopathological examinations. There were no significant findings at any dose level; a NOAEL of 150 mg/kg per day was concluded. As a supplement to the main study, histopathological examination of the prostate, seminal vesicles, mammary gland and testes of males and ovaries, mammary gland, uterus and vagina of females was undertaken on all animals in all test groups. This examination did not reveal any evidence of hormonal effects.

  16. Spectral imaging of the Orion Bar at 6.2 and 7.8 microns

    NASA Technical Reports Server (NTRS)

    Bregman, Jesse; Harker, David; Rank, David; Temi, Pasquale

    1995-01-01

    We have obtained images of the Orion Bar region through narrow-band filters at 6.2 and 7.8 mu m to determine whether the emission observed at these wavelengths arises from C-C modes in polycyclic aromatic hydrocarbons (PAH's). Morphologically, the distribution of the emissions are similar, but appear different in detail. Quantitative comparisons of these band intensities with previous data at 8.4 and 11.3 mu m indicates that they are indeed consistent with emission from fluorescently excited PAH molecules.

  17. High antiallergic activity of 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone and 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone from eau de cologne mint (Mentha×piperita citrata).

    PubMed

    Sato, Akihiko; Tamura, Hirotoshi

    2015-04-01

    The following compounds with higher antiallergic activities were isolated from eau de cologne mint leaves: 5,6,4'-trihydroxy-7,8-dimethoxyflavone (6), 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone (7), 5,6-dihydroxy-7,3',4'-trimethoxyflavone (8), 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone (9), and 5,6-dihydroxy-7,8,4'-trimethoxyflavone (10). The IC50 values of compounds 6-10 against RBL-2H3 cells were 6.7, 2.4, 5.6, 3.0, and 6.1μM. Compounds 7 and 9 (IC50 2.4μM and 3.0μM) had the highest antiallergic activities among the flavonoids previously reported. The amounts of 7, 9, and 10 isolated were fairly high, at 177.7mg/kg, 278.0mg/kg, and 179.7mg/kg in the mint, respectively. LD5 value (index of toxicity) and LD5/IC50 ratio of 7 and 9 indicate that the safety is greater than that of luteolin, a typical antiallergic substance. The extract containing powerful antiallergic flavones, 6-10 with higher hydrophobicity could be selectively separated from the extract containing luteolin and other flavonoid glycosides by partition with dichloromethane and water. Therefore, compounds 7 and 9 in mint, and the dichloromethane extract would be the most potent and preventive resources against type I allergy.

  18. Spectroscopy of 7He using the 9Be(6He,8Be) transfer reaction

    NASA Astrophysics Data System (ADS)

    Renzi, F.; Raabe, R.; Randisi, G.; Smirnov, D.; Angulo, C.; Cabrera, J.; Casarejos, E.; Keutgen, Th.; Ninane, A.; Charvet, J. L.; Gillibert, A.; Lapoux, V.; Nalpas, L.; Obertelli, A.; Skaza, F.; Sida, J. L.; Orr, N. A.; Sidorchuk, S. I.; Wolski, R.; Borge, M. J. G.; Escrig, D.

    2016-08-01

    The unbound nucleus 7He has been investigated via the reaction of a 16.8 MeV 6He radioactive ion beam on a 9Be target. The measurement of the outgoing 8Be through its well characterized two-α decay permitted the energy of the 6He+n system to be reconstructed. Through comparison with a complete Monte Carlo simulation incorporating R -matrix lineshapes, the 7He ground state was determined to lie 0.380(28) MeV above the neutron decay with a width of Γ =0.179 (21 ) MeV. A neutron spectroscopic factor SF=0.608 (18 ) was extracted in agreement with the most recent calculations. Significant evidence was found for a broad resonance lying at 2.6(2) MeV above threshold with a ΓFWHM=2.3 (3 ) MeV. These parameters are fully consistent with the properties of 1 /2- state reported by Wuosmaa et al. [Phys. Rev. C 72, 061301(R) (2005), 10.1103/PhysRevC.72.061301]. Limits were also put on the presence of narrow resonances seen in earlier experiments.

  19. A toxicological study of 5,6,7,8 tetrafluoro- 1,4-benzodioxin

    SciTech Connect

    London, J.E.

    1988-05-01

    The acute oral LD/sub 50/ values for 5,6,7,8 tetrafluro-1,4 benzodioxin for mice and rats are less than 5 gkg. According to classical guidelines, the material is considered slightly toxic in both species. The sensitization study in the guinea pig did not show the material to have potential sensitizing properties. Skin application studies on the rabbit demonstrated that it was cutaneously mildly irritating. This material was very mildly irritating in the rabbit eye application studies. 4 refs., 2 tabs.

  20. Source Parameters of the Deadly Mw 7.6 Kashmir Earthquake of 8 October, 2005

    NASA Astrophysics Data System (ADS)

    Mandal, Prantik; Chadha, R. K.; Kumar, N.; Raju, I. P.; Satyamurty, C.

    2007-10-01

    During the last six years, National Geophysical Research Institute, Hyderabad has established a semi-permanent seismological network of 5 8 broadband seismographs and 10 20 accelerographs in the Kachchh seismic zone, Gujarat with a prime objective to monitor the continued aftershock activity of the 2001 Mw 7.7 Bhuj mainshock. The reliable and accurate broadband data for the 8 October Mw 7.6 2005 Kashmir earthquake and its aftershocks from this network as well as Hyderabad Geoscope station enabled us to estimate the group velocity dispersion characteristics and one-dimensional regional shear velocity structure of the Peninsular India. Firstly, we measure Rayleigh-and Love-wave group velocity dispersion curves in the period range of 8 to 35 sec and invert these curves to estimate the crustal and upper mantle structure below the western part of Peninsular India. Our best model suggests a two-layered crust: The upper crust is 13.8 km thick with a shear velocity (Vs) of 3.2 km/s; the corresponding values for the lower crust are 24.9 km and 3.7 km/sec. The shear velocity for the upper mantle is found to be 4.65 km/sec. Based on this structure, we perform a moment tensor (MT) inversion of the bandpass (0.05 0.02 Hz) filtered seismograms of the Kashmir earthquake. The best fit is obtained for a source located at a depth of 30 km, with a seismic moment, Mo, of 1.6 × 1027 dyne-cm, and a focal mechanism with strike 19.5°, dip 42°, and rake 167°. The long-period magnitude (MA ~ Mw) of this earthquake is estimated to be 7.31. An analysis of well-developed sPn and sSn regional crustal phases from the bandpassed (0.02 0.25 Hz) seismograms of this earthquake at four stations in Kachchh suggests a focal depth of 30.8 km.

  1. Source Parameters of the 8 October, 2005 Mw7.6 Kashmir Earthquake

    NASA Astrophysics Data System (ADS)

    Mandal, Prantik; Chadha, R. K.; Kumar, N.; Raju, I. P.; Satyamurty, C.

    2007-12-01

    During the last six years, the National Geophysical Research Institute, Hyderabad has established a semi-permanent seismological network of 5 broadband seismographs and 10 accelerographs in the Kachchh seismic zone, Gujarat, with the prime objective to monitor the continued aftershock activity of the 2001 Mw7.7 Bhuj mainshock. The reliable and accurate broadband data for the Mw 7.6 (8 Oct., 2005) Kashmir earthquake and its aftershocks from this network, as well as from the Hyderabad Geoscope station, enabled us to estimate the group velocity dispersion characteristics and the one-dimensional regional shear-velocity structure of peninsular India. Firstly, we measure Rayleigh- and Love-wave group velocity dispersion curves in the range of 8 to 35 sec and invert these curves to estimate the crustal and upper mantle structure below the western part of peninsular India. Our best model suggests a two-layered crust: The upper crust is 13.8-km thick with a shear velocity (Vs) of 3.2 km/s; the corresponding values for the lower crust are 24.9 km and 3.7 km/sec. The shear velocity for the upper mantle is found to be 4.65 km/sec. Based on this structure, we perform a moment tensor (MT) inversion of the bandpass (0.05 0.02 Hz) filtered seismograms of the Kashmir earthquake. The best fit is obtained for a source located at a depth of 30 km, with a seismic moment, Mo, of 1.6 × 1027 dyne-cm, and a focal mechanism with strike 19.5°, dip 42°, and rake 167°. The long-period magnitude (MA ~ Mw) of this earthquake is estimated to be 7.31. An analysis of well-developed sPn and sSn regional crustal phases from the bandpassed (0.02 0.25 Hz) seismograms of this earthquake at four stations in Kachchh suggests a focal depth of 30.8 km.

  2. 3,5,5,6,8,8-Hexamethyl-5,6,7,8-tetra­hydro-2-naphthoic acid (AHTN–COOH)

    PubMed Central

    Kuhlich, Paul; Göstl, Robert; Metzinger, Ramona; Piechotta, Christian; Nehls, Irene

    2010-01-01

    The title compound, C17H24O2, is the product of a haloform reaction of 6-acetyl-1,1,2,4,4,7-hexa­methyl­tetra­line (AHTN). The compound is a racemic mixture with a disorder in its aliphatic ring [occupany ratio 0.683 (4):0.317 (4)] due to two possible half-chair forms. The carb­oxy­lic acid unit is slightly twisted out of coplanarity with the aromatic system [dihedral angle = 29.26 (6)°]. In the crystal, pairs of short classical inter­molecular O—H⋯O hydrogen bonds link pairs of mol­ecules around a center of symmetry. PMID:21587655

  3. First high resolution study of the interacting ν8 +ν10, ν6 +ν10, ν67 bands and re-analysis of the ν78 band of trans-d2-ethylene

    NASA Astrophysics Data System (ADS)

    Ulenikov, O. N.; Gromova, O. V.; Bekhtereva, E. S.; Aslapovskaya, Yu. S.; Ziatkova, A. G.; Sydow, C.; Maul, C.; Bauerecker, S.

    2016-11-01

    The high resolution IR spectrum of the trans-d2-ethylene (trans-C2H2D2) was recorded and analyzed in the region of 1450-1750 cm-1, where the strongly interacting bands ν8 +ν10, ν78, ν6 +ν10, and ν67 are located (one of the sub-bands of the hybrid ν78 band was analyzed earlier; transitions belonging to the three other bands were experimentally recorded and assigned in the present study for the first time). For description of the upper ro-vibrational energy levels obtained from the assigned transitions, the used Hamiltonian takes into account resonance interactions both between four studied vibrational states, (v8 =v10 = 1), (v7 =v8 = 1), (v6 =v10 = 1), (v6 =v7 = 1), and between the state (v6 =v7 = 1) and the additional fifth state (v4 =v8 = 1) which is considered in the present study as a "dark" state. About 2360, 2150, 2020 and 1700 transitions with the values Jmax. /Kamax. =31/21, 44/18, 28/18 and 27/17 were assigned to the bands ν8 +ν10, ν78, ν6 +ν10, and ν67, respectively. A set of 103 spectroscopic parameters was obtained from a weighted least square fit procedure. This reproduces the 550, 656, 441 and 435 upper ro-vibrational energies of the vibrational states (v8 =v10 = 1), (v7 =v8 = 1), (v6 =v10 = 1) and (v6 =v7 = 1) used in the fit with a drms = 2.5 ×10-4cm-1, which is close to the value of the mean experimental uncertainty (in this case, only upper energies obtained from unblended and nonsaturated transitions of relatively high intensities have been taken into account).

  4. Static stress change from the 8 October, 2005 M = 7.6 Kashmir earthquake

    USGS Publications Warehouse

    Parsons, T.; Yeats, R.S.; Yagi, Y.; Hussain, A.

    2006-01-01

    We calculated static stress changes from the devastating M = 7.6 earthquake that shook Kashmir on 8 October, 2005. We mapped Coulomb stress change on target fault planes oriented by assuming a regional compressional stress regime with greatest principal stress directed orthogonally to the mainshock strike. We tested calculation sensitivity by varying assumed stress orientations, target-fault friction, and depth. Our results showed no impact on the active Salt Range thrust southwest of the rupture. Active faults north of the Main Boundary thrust near Peshawar fall in a calculated stress-decreased zone, as does the Raikot fault zone to the northeast. We calculated increased stress near the rupture where most aftershocks occurred. The greatest increase to seismic hazard is in the Indus-Kohistan seismic zone near the Indus River northwest of the rupture termination, and southeast of the rupture termination near the Kashmir basin.

  5. Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis in C57BL/6 mice.

    PubMed

    Snyder, Jessica M; Treuting, Piper M; Nagy, Lee; Yam, Cathy; Yi, Jaehun; Brasfield, Alicia; Nguyen, Lisa Phuong Anh; Hajjar, Adeline M

    2014-01-01

    A humanized TLR7/TLR8 transgenic mouse line was engineered for studies using TLR7/8 ligands as vaccine adjuvants. The mice developed a spontaneous immune-mediated phenotype prior to six months of age characterized by runting, lethargy, blepharitis, and corneal ulceration. Histological examination revealed a marked, multisystemic histiocytic infiltrate that effaced normal architecture. The histological changes were distinct from those previously reported in mouse models of systemic lupus erythematosus. When the mice were crossed with MyD88-/- mice, which prevented toll-like receptor signaling, the inflammatory phenotype resolved. Illness may be caused by constitutive activation of human TLR7 or TLR8 in the bacterial artificial chromosome positive mice as increased TLR7 and TLR8 expression or activation has previously been implicated in autoimmune disease. PMID:25229618

  6. Synthesis and characterization of p-type conductivity dopant 2-(3-(adamantan-1-yl)propyl)-3,5,6-trifluoro-7,7,8,8-tetracyanoquinodimethane

    SciTech Connect

    Rainbolt, James E.; Koech, Phillip K.; Polikarpov, Evgueni; Swensen, James S.; Cosimbescu, Lelia; Von Ruden, Amber L.; Wang, Liang; Sapochak, Linda S.; Padmaperuma, Asanga B.; Gaspar, Daniel J.

    2013-01-22

    We report the synthesis and characterization of 2-(3-(adamantan-1-yl)propyl)-3,5,6-trifluoro-7,7,8,8-tetracyanoquinodimethane (F3TCNQ-Ad1), a substituted analog of 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ), designed for p-type conductivity doping. The dopant is designed as a model for substituted alternatives to F4TCNQ that maintain similar electronic properties with the goal of engineering dopants with superior fabrication characteristics over F4TCNQ. We describe the design strategy for F3TCNQ-Ad1 based on molecular modeling predictions that substitution of a single fluorine atom of F4TCNQ has little effect on the electronic properties of the molecule. Photophysical and electrochemical characterization reveal that the adamantyl substituent in F3TCNQ-Ad1 does not significantly alter the electronic properties of the substituted dopant relative to F4TCNQ. Unfortunately, F3TCNQ-Ad1 degrades under standard sublimation conditions, preventing sublimation deposition processing. Instead, hole-only devices were made via solution-processing of the p-doped films with the structure glass/ITO/2.3 x103Å PVK:(MTDATA:dopant)/2.0x102Å Au/1.0x103Å Al, where dopant is either F4TCNQ or F3TCNQ-Ad1. We demonstrate that F3TCNQ-Ad1 increased the conductivity of the films by at least 1,000 times compared to an undoped device.

  7. Technological Studies at Thomas Edison Middle School. Grades 6-7-8.

    ERIC Educational Resources Information Center

    Foster, Patrick N.

    This technology studies curriculum for grades 6-8 is a plan for each middle school student to experience technology education for approximately 60 days (1 trimester of a 180-day school year) in each grade. Section A provides definitions; structure or content for grade-level programs with science and technology unifiers (unifying curricular…

  8. Effects of 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane doping on diketopyrrolopyrrole-based, low crystalline, high mobility polymeric semiconductor

    SciTech Connect

    Yoon, Seongwon; Cho, Jangwhan; Chung, Dae Sung; Lee, Han-Koo; Park, Sungmin; Son, Hae Jung

    2015-09-28

    The effects of 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ) doping on diketopyrrolo-pyrrole-based polymeric semiconductors in terms of charge transport behavior and structural ordering are systematically investigated. Although the energy level offset between the polymeric semiconductor and the F4TCNQ acceptor was not particularly large, ultraviolet photoelectron spectroscopy analyses revealed that a low doping ratio of 1 wt. % is sufficient to tune the energy distance between the Fermi level and the HOMO level, reaching saturation at roughly 5 wt. %, which is further confirmed by the depletion mode measurements of field effect transistors (FETs). Structural analyses using grazing-incidence X-ray diffraction (GIXD) show that the overall degree of edge-on orientation is disturbed by the addition of dopants, with significant influence appearing at high doping ratios (>3 wt. %). The calculated charge carrier mobility from accumulation mode measurements of FETs showed a maximum value of 2 cm{sup 2}/V·s at the optimized doping ratio of 1%, enabled by additional holes in the channel region, which results in a roughly 40% increase relative to the undoped device. Further increases in the doping ratio, however, resulted in worse FET performance, which can be attributed to structural deformation. This result suggests that the electrochemical doping method can be also applied to donor-acceptor copolymers to further enhance their charge transport characteristics, once the optimized doping condition has been established.

  9. Process for manufacturing bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene

    DOEpatents

    Rasmussen, Paul George; Lawton, Richard Graham

    2014-06-03

    A process to manufacture substituted tetracyano-hexaazatricyclics with the substitutions occurring at the 9 and 10 hydrogens. The process begins with 2,3-dichloro-5,6-dicyanopyrazine, which is reacted to form the desired tetracyano-hexaazatricyclic. Different process embodiments enable different reaction paths to the desired tetracyano-hexaazatricyclic. Different tetracyano-hexaazatricyclic embodiments include bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene and bis(2-methoxyethoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracen- e.

  10. Biosynthesis of riboflavin. An aliphatic intermediate in the formation of 6,7-dimethyl-8-ribityllumazine from pentose phosphate.

    PubMed

    Neuberger, G; Bacher, A

    1985-02-28

    6,7-Dimethyl-8-ribityllumazine synthase deficient mutants of Candida guilliermondii were divided into two groups on the basis of in vitro complementation. Mutants of complementation group I produce an intermediate X from ribose 5-phosphate in a reaction requiring Mg++ ions. Compound X was partially purified and was shown to be a phosphoric acid ester. 6,7-Dimethyl-8-ribityllumazine can be formed from Compound X by cell extracts from mutants of complementation group II. The reaction requires 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione or its 5'-phosphate as second substrate. No divalent cations are required. PMID:3838473

  11. Pioneer 6 through 8

    NASA Technical Reports Server (NTRS)

    Lozier, D.; Fimmel, R.

    1991-01-01

    The DSN (Deep Space Network) mission support requirements for Pioneer 6, 7 and 8 are summarized. The primary objective of these Pioneer missions is to collect scientific data relative to interplanetary phenomena within a range of approximately 0.8 to 1.2 astronomical units from the sun. Following orbital injection, each spacecraft was oriented with its spin axis normal to the ecliptic plane so that the high gain antenna pattern would be aligned with Earth's orbit. The mission objectives are outlined and the DSN support requirements are defined through the presentation of tables and narratives describing the spacecraft flight profiles; DSN support coverage; frequency assignments; support parameters for telemetry, command and support systems; and tracking support responsibility.

  12. Fragrance material review on 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE).

    PubMed

    Scognamiglio, J; Letizia, C S; Politano, V T; Api, A M

    2013-12-01

    A toxicologic and dermatologic review of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE) when used as a fragrance ingredient is presented. OTNE is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for OTNE were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, elicitation, phototoxicity, photoallergy, toxicokinetics, repeated dose, reproductive toxicity, and genotoxicity data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (2013) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances.

  13. The interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) and 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) in TCDD-induced porphyria

    SciTech Connect

    Yao, Cheng Catsby.

    1989-01-01

    Halogenated aryl hydrocarbon(HAH)-induced porphyria is caused by alteration of porphyrin metabolism and results in the accumulation of hepatic and urinary porphyrins. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (75 {mu}/kg) caused significant increases of hepatic porphyrin levels in C57BL/6 male, female and ovariectomized female, and C57BL/10 male mice 3 weeks after treatment. In contrast, 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) was inactive at a dose of 750 {mu}mol/kg. Cotreatment with MCDF (750 {mu}mol/kg) and 2,3,7,8-TCDD (75 {mu}g/kg) resulted in partial antagonism of 2,3,7,8-TCDD-induced porphyrin accumulation in female but not in male mice. In female C57BL/6 mice, 2,3,7,8-TCDD-induced porphyria was accompanied by the induction of hepatic microsomal aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin O-deethylase (EROD) activities and the inhibition of uroporphyrinogen decarboxylase (UROD) activity. MCDF (750 {mu}mol/kg) did not significantly affect these enzyme activities. In coadministration studies, MCDF partially antagonized 2,3,7,8-TCDD-induced hepatic porphyrin accumulation but did not affect the activities of hepatic AHH, EROD or UROD. These results demonstrate that the induction of the monooxygenase enzyme activities and the inhibition of UROD activity by 2,3,7,8-TCDD and the development of porphyria are not coordinately regulated in C57BL/6 female mice. In cultured chick embryo hepatocytes, 2,3,7,8-TCDD caused a significant increase in porphyrin levels and induced AHH and EROD activities. MCDF and Aroclor 1254 partially antagonized the 2,3,7,8-TCDD induced AHH and EROD activities but not the porphyrin accumulation.

  14. Disposition and excretion of 14C-AHTN (7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) and 14c-hhcb (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran) after intravenous administration to Sprague-Dawley rats and domestic pigs.

    PubMed

    Api, Anne Marie; Ritacco, Gretchen; Sipes, I Glenn

    2013-07-01

    7-Acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene (AHTN ) and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran (HHCB) are polycyclic musks widely used as fragrance ingredients in consumer products. Because their metabolic fate following systemic exposure is not fully characterized, disposition and excretion of (14)C-AHTN- and (14)C-HHCB-derived radioactivity were studied in Sprague-Dawley rats and domestic pigs following a single intravenous dose. Rats administered with AHTN or HHCB excreted 21% or 28% of the radioactivity in urine and 67% or 61% in feces, respectively, within 7 days. In pigs administered AHTN or HHCB, 86% or 74% of the dose was excreted in the urine, and 12% or 15% in feces, respectively, during the 14-day collection period. Radioactivity in the whole blood and plasma of both species and tissues of rats declined steadily until the end of the study (28 days) for both the materials. Radioactivity in rat adipose tissue reached peak at 2 hours after dosing, decreasing steadily thereafter. Radioactivity in pig blood declined rapidly from 70 ng equivalents/g at 10 minutes to 1 ng equivalent/g or less by 28 days after administration of either AHTN or HHCB. Radioactivity in pig skin and adipose tissue decreased to below the limit of detection by 28 days for both the materials. Thin-layer chromatography showed multiple radioactive components in both species' urine after administration of either material. Components found in the urine of the 2 species were qualitatively similar but quantitatively different. Both AHTN and HHCB were completely metabolized and excreted. No unchanged parent compound was detected in rat or pig urine.

  15. Primary School English Teachers' Perceptions of the English Language Curriculum of 6th, 7th and 8th Grades

    ERIC Educational Resources Information Center

    Ersen Yanik, Asli

    2008-01-01

    This study aims to investigate how the teachers who have different background characteristics perceive the goals and content of the English language curriculum implemented at the 6th, 7th and 8th grades of public primary schools. The study was conducted during the 2004-2005 school year with 368 English teachers selected from the seven regions of…

  16. 1,5-Dichloro-3(2,7),7(2,7)-dinaphthal-ena-2,4,6,8-tetra-oxa-1(2,6),5(2,6)-di(1,3,5-triazina)octa-phane.

    PubMed

    Sang, Qiu-Guang; Yang, Jing-Kui

    2011-09-01

    In the macrocyclic title compound, C(26)H(12)Cl(2)N(6)O(4), an O-atom-bridged calix[2]naphthalene-[2]triazine synthesized using a one-pot approach from naphthalene-2,7-diol and cyanuric chloride, the two isolated naphthalene planes and the two triazine-2,6-di-oxy planes adopt a 1,3-alternate configuration, with a dihedral angle of 84.10 (8)° between the naphthalene rings and a dihedral angle of 39.02 (14)° between the triazine rings. In the crystal, weak inter-molecular π-π stacking inter-actions are found between face-to-face naphthalene rings [centroid-centroid distance = 3.662 (7) Å].

  17. Reactions of vitamin E and its model compound 2,2,5,7,8-pentamethylchroman-6-ol with ozone

    SciTech Connect

    Liebler, D.C.; Matsumoto, Shigenobu; Matsuo, Mitsuyoshi; Iitaka, Yoichi

    1993-01-01

    Reaction of vitamin E [(R,R,R,)-{alpha}-tocopherol] with ozone in acetonitrile yielded {alpha}-tocopheryl quinone and its precursor 8{alpha}-hydroxytocopherone, which accounted for approximately 30% of the products at <50% {alpha}-tocopherol oxidation. In addition, two novel products were identified as epimers of 10-acetyl-7-(4{prime},8{prime},12{prime}-trimethyl tridecyl)-3,4,7-trimethyl-2-oxo - 1,6-dioxaspiro[4.5]-deca-3,9-diene. These spiro products were formed in equal amounts in a combined yield of approximately 33% after complete {alpha}-tocpherol oxidation. Ozonation of the vitamin E model compound 2,2,5,7,8-pentamethylchroman-6-ol yielded an analogous spiro product, 10-acetyl-3,4,7,7-tetramethyl-2-oxo-1,6-dioxaspiro[4.5]deca-3,9-diene, whose structure was confirmed by X-ray crystallography. The spiro products may be formed by ozone addition to the chroman ring and subsequent rearrangement to ring-opened hydroxyacid products, which yield spiro products by ring closure due to dehydration. Novel spiro products formed by ozonation of vitamin E may be unique markers of ozone interaction with lipid structures that contain vitamin E. 39 refs., 3 figs., 1 tab.

  18. Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD

    Integrated Risk Information System (IRIS)

    Hexachlorodibenzo - p - dioxin ( HxCDD ) , mixture of 1,2,3,6,7,8 - HxCDD and 1,2,3,7,8,9 - HxCDD ; CASRN 57653 - 85 - 7 and 19408 - 74 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in

  19. 7 CFR 6.2 - Responsibility for actions under section 22 and section 8(a).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... under section 22 of the Agricultural Adjustment Act of 1933, as amended, and section 8(a) of the Trade Agreements Extension Act of 1951 is assigned to the Administrator, Foreign Agricultural Service (referred...

  20. 7 CFR 6.2 - Responsibility for actions under section 22 and section 8(a).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... under section 22 of the Agricultural Adjustment Act of 1933, as amended, and section 8(a) of the Trade Agreements Extension Act of 1951 is assigned to the Administrator, Foreign Agricultural Service (referred...

  1. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H{sub 2} hydrogenation reaction network.

  2. Novel synthetic approach to 6,7-dihydro-5H-imidazo[1,5-a]-pyrazin-8-ones.

    PubMed

    Gopalsamy, Ariamala; Shi, Mengxiao

    2003-10-16

    [reaction: see text] A novel route to highly substituted chiral 6,7-dihydro-5H-imidazo[1,5-a]pyrazine-8-ones starting from Meldrum's acid is disclosed. The key features of the methodology are the incorporation of amino esters as a chiral pool and facile mild intramolecular cyclization to form the pyrazine ring. Incorporation of various substituents at different stages of the synthesis from various building block sets makes this methodology readily amenable to parallel synthesis. PMID:14535740

  3. Organocatalyzed enantioselective synthesis of 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylates

    PubMed Central

    Ramireddy, Naresh; Abbaraju, Santhi; Zhao, Cong-Gui

    2011-01-01

    The organocatalyzed enantioselective synthesis of biologically active 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate derivatives was achieved using bifunctional cinchona alkaloids as the catalysts. Using quinine thiourea as the catalyst, the tandem Michael addition-cyclization reaction between 1,3-cyclohexanediones and alkylidenecyanoacetate derivatives gives the desired products in high yields (up to 92%) and good ee values (up to 82%). PMID:22081731

  4. 3,3,6,6,9,9-Hexaethyl-1,2,4,5,7,8-hexaoxacyclononane at 296 K.

    PubMed

    Cerna, Jorge; Bernès, Sylvain; Cañizo, Adriana; Eyler, Nora

    2009-11-01

    The title molecule (diethyl ketone triperoxide, DEKTP), C(15)H(30)O(6), is a cyclic triperoxide closely related to triacetone triperoxide (TATP), one of the most unstable explosives known. However, the stability of DEKTP is ca 20-50 times greater than that of TATP. DEKTP crystallizes with two molecules in the asymmetric unit, with virtually identical geometry. The cyclononane core is stabilized in a twisted boat-chair conformation (approximate D(3) symmetry), very close to that previously described for TATP. The explanation for the safe thermal behaviour of DEKTP compared with TATP should thus not be sought in the molecular dimensions, but rather in the thermal decomposition kinetics. PMID:19893236

  5. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New lead exhibits a distinct binding mode

    PubMed Central

    Shi, Genbin; Shaw, Gary; Li, Yue; Wu, Yan; Yan, Honggao; Ji, Xinhua

    2012-01-01

    6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), a key enzyme in the folate biosynthesis pathway catalyzing the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin, is an attractive target for developing novel antimicrobial agents. Previously, we studied the mechanism of HPPK action, synthesized bisubstrate analogue inhibitors by linking 6-hydroxymethylpterin to adenosine through phosphate groups, and developed a new generation of bisubstrate inhibitors by replacing the phosphate bridge with a piperidine-containing linkage. To further improve linker properties, we have synthesized a new compound, characterized its protein binding/inhibiting properties, and determined its structure in complex with HPPK. Surprisingly, this inhibitor exhibits a new binding mode in that the adenine base is flipped when compared to previously reported structures. Furthermore, the side chain of amino acid residue E77 is involved in protein-inhibitor interaction, forming hydrogen bonds with both 2' and 3' hydroxyl groups of the ribose moiety. Residue E77 is conserved among HPPK sequences, but interacts only indirectly with the bound MgATP via water molecules. Never observed before, the E77-ribose interaction is compatible only with the new inhibitor-binding mode. Therefore, this compound represents a new direction for further development. PMID:22727779

  6. MISSE 6, 7 and 8 Materials Sample Experiments from the International Space Station Materials and Processes Team

    NASA Technical Reports Server (NTRS)

    Kravchenko, Michael; ORourke, Mary Jane; Golden, Johnny; Finckenor, Miria; Leatherwood, Michael; Alred, John

    2010-01-01

    The International Space Station Materials and Processes (ISS M&P) team has multiple material samples on MISSE 6, 7 and 8 to observe Low Earth Orbit (LEO) environmental effects on Space Station materials. Optical properties, thickness/mass loss, surface elemental analysis, visual and microscopic analysis for surface change are some of the techniques employed in this investigation. The ISS M&P team has participated in previous MISSE activities in order to better characterize the LEO effects on Space Station materials. This investigation will further this effort. Results for the following MISSE 6 samples materials will be presented: a comparison of anodize and chemical conversion coatings on various aluminum alloys, electroless nickel; AZ93 white ceramic thermal control coating with and without Teflon; Hyzod(TM) polycarbonate used to temporarily protect ISS windows; Russian quartz window material; reformulated Teflon (TM) coated Beta Cloth (Teflon TM without perfluorooctanoic acid (PFOA)) and a Dutch version of beta cloth. Discussion for current and future MISSE materials experiments will be presented. MISSE 7 samples are: deionized water sealed anodized aluminum Photofoil(TM); indium tin oxide (ITO)- coated Kapton(TM) used as thermo-optical surfaces; mechanically scribed tin-plated beryllium-copper samples for "tin pest" growth ( alpha/Beta transformation); Crew Exploration Vehicle (CEV) parachute soft goods. MISSE 8 sample: exposed "scrim cloth" (fiberglass weave) from the ISS solar array wing material, Davlyn fiberglass sleeve material, Permacel and Intertape protective tapes, and ITO-coated Kapton.

  7. An immunocytochemical mapping of methionine-enkephalin-Arg6-Gly7-Leu8 in the cat brainstem.

    PubMed

    Belda, Magdalena; Coveñas, Rafael; Narváez, José Angel; Aguirre, José Angel; Tramu, Gérard

    2003-04-01

    The distribution of methionine-enkephalin-Arg6-Gly7-Leu8-immunoreactive cell bodies and fibres was studied in the brainstem of the cat using an indirect immunoperoxidase technique. In the mesencephalon, immunoreactive cell bodies were observed in the periaqueductal grey, the dorsal raphe nucleus, the central and pericentral nuclei of the inferior colliculus and the pericentral division of the dorsal tegmental nucleus. In the pons, immunoreactive cell bodies were observed in the dorsolateral division of the pontine nucleus; below the central division of the dorsal tegmental nucleus; above the dorsolateral division of the pontine nucleus, and close to the superior cerebellar peduncle. In the medulla oblongata, immunoreactive cell bodies were observed in the laminar spinal trigeminal nucleus and in the lateral tegmental field; the dorsal motor nucleus of the vagus; the prepositus hypoglossal nucleus; the medial nucleus of the solitary tract; the rostral division of the cuneate nucleus, and close to the parvocellular division of the alaminar spinal trigeminal nucleus. The highest (moderate) density of immunoreactive fibres was observed in the periaqueductal grey; the parvocellular and magnocellular divisions of the alaminar spinal trigeminal nucleus; the laminar spinal trigeminal nucleus; the rostral division of the cuneate nucleus; the dorsal motor nucleus of the vagus; the lateral nucleus of the solitary tract, and in the midline between the central divisions of the reticulotegmental pontine nucleus. The widespread distribution of methionine-enkephalin-Arg6-Gly7-Leu8 in the cat brainstem indicates that the peptide might be involved in several physiological functions.

  8. Crystal structure of a prokaryotic (6-4) photolyase with an Fe-S cluster and a 6,7-dimethyl-8-ribityllumazine antenna chromophore.

    PubMed

    Zhang, Fan; Scheerer, Patrick; Oberpichler, Inga; Lamparter, Tilman; Krauß, Norbert

    2013-04-30

    The (6-4) photolyases use blue light to reverse UV-induced (6-4) photoproducts in DNA. This (6-4) photorepair was thought to be restricted to eukaryotes. Here we report a prokaryotic (6-4) photolyase, PhrB from Agrobacterium tumefaciens, and propose that (6-4) photolyases are broadly distributed in prokaryotes. The crystal structure of photolyase related protein B (PhrB) at 1.45 Å resolution suggests a DNA binding mode different from that of the eukaryotic counterparts. A His-His-X-X-Arg motif is located within the proposed DNA lesion contact site of PhrB. This motif is structurally conserved in eukaryotic (6-4) photolyases for which the second His is essential for the (6-4) photolyase function. The PhrB structure contains 6,7-dimethyl-8-ribityllumazine as an antenna chromophore and a [4Fe-4S] cluster bound to the catalytic domain. A significant part of the Fe-S fold strikingly resembles that of the large subunit of eukaryotic and archaeal primases, suggesting that the PhrB-like photolyases branched at the base of the evolution of the cryptochrome/photolyase family. Our study presents a unique prokaryotic (6-4) photolyase and proposes that the prokaryotic (6-4) photolyases are the ancestors of the cryptochrome/photolyase family.

  9. Study on the 8He ground state via 8He(p, d)7He and 8He(p, t)6He reaction at 82.3 MeV/nucleon

    NASA Astrophysics Data System (ADS)

    Lou, J. L.; Ye, Y. L.; Pang, D. Y.; Cao, Z. X.; Jiang, D. X.

    2013-03-01

    The differential cross sections for reactions 8He(p, d)7Heg.s and 8He(p, t)6He2+ were measured by the coincidence of d + 6 He and t + 4He in a wide angular range from 15 to 130 degree in the center-of-mass system. The cross sections of the 8He(p, t)6Heg.s reaction were extremely lower than that of 8He(p, t)6He2+ reaction, and was not obtained from the present data. The experimental results were compared to the preliminary theoretical calculations in the frame of adiabatic distorted-wave approximation with the code Fresco. The results show that the configuration of (1p3/2)2(1p1/2)2 may have some probability in the ground state wave function of 8He. The cluster structure of 8He = 5H + 3H could not be neglected.

  10. Different requirements for proteolytic processing of bone morphogenetic protein 5/6/7/8 ligands in Drosophila melanogaster.

    PubMed

    Fritsch, Cornelia; Sawala, Annick; Harris, Robin; Maartens, Aidan; Sutcliffe, Catherine; Ashe, Hilary L; Ray, Robert P

    2012-02-17

    Bone morphogenetic proteins (BMPs) are synthesized as proproteins that undergo proteolytic processing by furin/subtilisin proprotein convertases to release the active ligand. Here we study processing of BMP5/6/7/8 proteins, including the Drosophila orthologs Glass Bottom Boat (Gbb) and Screw (Scw) and human BMP7. Gbb and Scw have three functional furin/subtilisin proprotein convertase cleavage sites; two between the prodomain and ligand domain, which we call the Main and Shadow sites, and one within the prodomain, which we call the Pro site. In Gbb each site can be cleaved independently, although efficient cleavage at the Shadow site requires cleavage at the Main site, and remarkably, none of the sites is essential for Gbb function. Rather, Gbb must be processed at either the Pro or Main site to produce a functional ligand. Like Gbb, the Pro and Main sites in Scw can be cleaved independently, but cleavage at the Shadow site is dependent on cleavage at the Main site. However, both Pro and Main sites are essential for Scw function. Thus, Gbb and Scw have different processing requirements. The BMP7 ligand rescues gbb mutants in Drosophila, but full-length BMP7 cannot, showing that functional differences in the prodomain limit the BMP7 activity in flies. Furthermore, unlike Gbb, cleavage-resistant BMP7, although non-functional in rescue assays, activates the downstream signaling cascade and thus retains some functionality. Our data show that cleavage requirements evolve rapidly, supporting the notion that changes in post-translational processing are used to create functional diversity between BMPs within and between species.

  11. Validating Geant4 Versions 7.1 and 8.3 Against 6.1 for BaBar

    SciTech Connect

    Banerjee, Swagato; Brown, David N.; Chen, Chunhui; Cote, David; Dubois-Felsmann, Gregory P.; Gaponenko, Igor; Kim, Peter C.; Lockman, William S.; Neal, Homer A.; Simi, Gabriele; Telnov, Alexandre V.; Wright, Dennis H.; /SLAC

    2011-11-08

    Since 2005 and 2006, respectively, Geant4 versions 7.1 and 8.3 have been available, providing: improvements in modeling of multiple scattering; corrections to muon ionization and improved MIP signature; widening of the core of electromagnetic shower shape profiles; newer implementation of elastic scattering for hadronic processes; detailed implementation of Bertini cascade model for kaons and lambdas, and updated hadronic cross-sections from calorimeter beam tests. The effects of these changes in simulation are studied in terms of closer agreement of simulation using Geant4 versions 7.1 and 8.3 as compared to Geant4 version 6.1 with respect to data distributions of: the hit residuals of tracks in BABAR silicon vertex tracker; the photon and K{sub L}{sup 0} shower shapes in the electromagnetic calorimeter; the ratio of energy deposited in the electromagnetic calorimeter and the flux return of the magnet instrumented with a muon detection system composed of resistive plate chambers and limited-streamer tubes; and the muon identification efficiency in the muon detector system of the BABAR detector.

  12. Protective effects of (6R)-5,6,7,8-tetrahydro-l-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva

    PubMed Central

    Tanaka, Yusaku; Toyama, Toshizo; Wada-Takahashi, Satoko; Sasaki, Haruka; Miyamoto, Chihiro; Maehata, Yojiro; Yoshino, Fumihiko; Yoshida, Ayaka; Takahashi, Shun-suke; Watanabe, Kiyoko; Lee, Masaichi-Chang-il; Todoki, Kazuo; Hamada, Nobushiro

    2016-01-01

    We herein investigated the regulatory mechanism in the circulation responsible for rat gingival reactive hyperemia (RH) associated with ischemia/reperfusion (I/R). RH was analyzed using a laser Doppler flowmeter. RH and I/R were elicited by gingival compression and release with a laser Doppler probe. RH increased in a time-dependent manner when the duration of compression was between 30 s and 20 min. This increase was significantly suppressed by Nω-nitro-l-arginine-methyl-ester (l-NAME), 7-nitroindazole (7-NI), and 2,4-diamino-6-hydroxypyrimidine (DAHP). However, RH was markedly inhibited following 60 min of compression. This inhibition was significantly decreased by treatments with superoxide dismutase (SOD), (6R)-5,6,7,8-tetrahydro-l-biopterin (BH4), and sepiapterin. The luminescent intensity of superoxide anion (O2•−)-induced 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo-[1,2-a] pyrazine-3-one (MCLA) was markedly decreased by SOD and BH4, but only slightly by sepiapterin. BH4 significantly decreased O2•− scavenging activity in a time-dependent manner. These results suggested that nitric oxide (NO) secreted by the nitrergic nerve played a role in regulating local circulation in rat gingiva. This NO-related regulation of local circulation was temporarily inhibited in the gingiva by the I/R treatment. The decrease observed in the production of NO, which was caused by suppression of NO synthase (NOS) activity subsequent to depletion of the NOS co-factor BH4 by O2•−, played a partial role in this inhibition. PMID:26798200

  13. Simulation of Strong Ground Motion for the 7.6Mw Kashmir Earthquake Occurred on 8 Oct 2005

    NASA Astrophysics Data System (ADS)

    Naveed, A.; Muhammad sohail, K.

    2015-12-01

    The Mw 7.6 Kashmir earthquake which struck the northern area of Pakistan , the Kashmir region on 8 October 2005.The epicenter was located 18km north-northeast of Muzaffarabad, with a focal depth of 26km and it occurred in the Hazara-kashmir syntaxial bend near Main Mantle Thrust (MMT). This is one of the most devastating earthquakes occurred along Himalayan Arc and brought more than 80,000 deaths and more than 5.2 billion USD economical loss. The earthquake had duration of 25s and 75km rupture length along the surface. In order to investigate the strong motion caused by this earthquake, we simulate the Kashmir earthquake by the Curved grid finite difference method (CG-FDM). The finite-fault rupture, real topography variations and modified crustal model are considered. Simulated results are compared with available records, showing good mutual agreement between the synthetic and observed ground motions. According to the Pakistan Meteorological Department (PMD), the intensity of four observed points had reached scale IX, whereas our simulated results show those points are located in the regions with our predicted intensity scale IX or VIII. Peak Ground Acceleration (PGA) and Peak ground velocity (PGV) are most important parameters for hazard analysis, and our results are sufficiently coincide with their observed values. Finally, we also discuss the significant effect of surface topography on ground motion resulting by the Earthquake.

  14. One protein, two chromophores: comparative spectroscopic characterization of 6,7-dimethyl-8-ribityllumazine and riboflavin bound to lumazine protein.

    PubMed

    Paulus, Bernd; Illarionov, Boris; Nohr, Daniel; Roellinger, Guillaume; Kacprzak, Sylwia; Fischer, Markus; Weber, Stefan; Bacher, Adelbert; Schleicher, Erik

    2014-11-20

    We investigated the lumazine protein from Photobacterium leiognathi in complex with its biologically active cofactor, 6,7-dimethyl-8-ribityllumazine, at different redox states and compared the results with samples containing a riboflavin cofactor. Using anaerobic photoreduction, we were able to record optical absorption kinetics from both cofactors in similar protein environments. It could be demonstrated that the protein is able to stabilize a neutral ribolumazine radical with ∼35% yield. The ribolumazine radical state was further investigated by W-band continuous-wave EPR and X-band pulsed ENDOR spectroscopy. Here, both the principal values of the g-tensor and an almost complete mapping of the proton hyperfine couplings (hfcs) could be obtained. Remarkably, the g-tensor's principal components are similar to those of the respective riboflavin-containing protein; however, the proton hfcs show noticeable differences. Comparing time-resolved optical absorption and fluorescence data from ribolumazine-containing samples, solely fluorescence but no signs of any intermediate radical or a triplet state could be identified. This is in contrast to lumazine protein samples containing the riboflavin cofactor, for which a high yield of the photogenerated triplet state and some excited flavin radical could be detected using time-resolved spectroscopy. These results clearly demonstrate that ribolumazine is a redox-active molecule and could, in principle, be employed as a cofactor in other enzymatic reactions.

  15. Single-Step Synthesis of 5,6,7,8-Tetrahydroindolizines via Annulation of 2-Formylpiperidine and 1,3-Dicarbonyl Compounds.

    PubMed

    Capomolla, Simona S; Lim, Ngiap-Kie; Zhang, Haiming

    2015-07-17

    An expedient single-step synthesis of 5,6,7,8-tetrahydroindolizines has been achieved via the annulation of commercially available 2-formylpiperidine hydrochloride and 1,3-dicarbonyl compounds in THF in the presence of pyrrolidine and 4 Å molecular sieves. A variety of β-ketoesters, ketones, and amides participated in this annulation chemistry, affording the desired 5,6,7,8-tetrahydroindolizines in moderate to good yields.

  16. (2aR*,5S*,6aS*,8aS*,E)-Ethyl 5-hy­droxy-7,7,8a-trimethyl-8-oxo-2,2a,6,6a,7,8,8a,8b-octa­hydro-1H-penta­leno[1,6-bc]oxepine-4-carboxyl­ate

    PubMed Central

    Mehta, Goverdhan; Kumar, C. S. Ananda; Sen, Saikat

    2012-01-01

    The title compound, C17H24O5, featuring a 2-carbeth­oxy-3-oxepanone unit in its intra­molecularly O—H⋯O hydrogen-bonded enol form, was obtained via [(CF3CO2)2Rh]2-catal­ysed intra­molecular O—H bond insertion in the α-diazo-ω-hy­droxy-β-ketoester, ethyl 4-[(1S,3aS,6R,6aS)-6-hy­droxy-2,2,3a-trimethyl-3-oxo-octa­hydro­penta­len-1-yl]-2-diazo-3-oxobutano­ate. The seven-membered oxacyclic ring, thus constructed on a cis-fused diquinane platform, was found to adopt a distorted boat–sofa conformation. PMID:23476221

  17. The epithelial differentiating activity in vivo of (E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl) -1-propenyl]benzoic acid and 4,4-difluororetinoic acid.

    PubMed Central

    Miller, D A; Stephens-Jarnagin, A; DeLuca, H F

    1985-01-01

    Female rats fed on a vitamin A-deficient diet from weaning were oophorectomized after introitus and used to test analogues of all-trans-retinoic acid for epithelial differentiation activity by the vaginal-smear assay. Several modifications have been made in the assay; housing facilities were modified, the diet changed and the existing scoring system for the assay altered. The arotinoid (E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl)-1 -propenyl] benzoic acid was 12-fold more active than all-trans-retinoic acid, which had a 50% effective dose (ED50) of 80 pmol/vagina. The fluorinated analogue 4,4-difluororetinoic acid had an ED50 of 2.5 nmol/vagina and was therefore 30-fold less active than all-trans-retinoic acid. PMID:3994687

  18. Immunogenicity of porcine P[6], P[7]-specific △VP8* rotavirus subunit vaccines with a tetanus toxoid universal T cell epitope.

    PubMed

    Wen, Xiaobo; Wei, Xiaoman; Ran, Xuhua; Ni, Hongbo; Cao, Si; Zhang, Yao

    2015-08-26

    Currently, commercial porcine rotavirus vaccines remain varied limitations. The objective of this study is to develop an alternative porcine rotavirus subunit vaccine candidate by parenteral administration, which enables to elicit robust immune responses against most prevalence porcine rotavirus strains. The bacterially-expressed porcine rotavirus P[6]- or P[7]-specific truncated VP8* (aa 64-223) recombinant protein with or without a universal tetanus toxoid CD4(+) T cell epitope P2 was generated. All the recombinant subunit proteins △VP8*s or P2-△VP8*s were of high solubility and high yields. The immunogenicity of each purified △VP8* and P2-△VP8* was evaluated in mice (10 μg/dose) or guinea pigs (20 μg/dose) immunized IM with 600 μg aluminum hydroxide three times at 2-week interval. The introduction of P2T cell epitope to P[7]-△VP8* elicited significantly higher IgG titer in mice than its absence. Comparatively, P2 epitope slightly enhanced the immunogenicity of P[6]-△VP8*. P2-P[7]△VP8* elicited high titer of neutralizing antibody against heterotypic P[7]-specific rotaviruses with varied G type combination. Our data indicated that two subunit vaccines could be plausible bivalent rotavirus vaccine candidate to provide antigenic coverage of porcine rotavirus strains of global or regional importance.

  19. Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors.

    PubMed

    Gulcan, Hayrettin Ozan; Unlu, Serdar; Esiringu, Ilker; Ercetin, Tugba; Sahin, Yasemin; Oz, Demet; Sahin, Mustafa Fethi

    2014-10-01

    Hydroxylated 6H-benzo[c]chromen-6-one derivatives (i.e., urolithins) are the main bioavailable metabolites, and biomarkers of ellagitannins present in various nutrition. Although these dietaries, the sources of urolithins, are employed in folk medicine as cognitive enhancer in the treatment of Alzheimer's Disease, urolithins have negligible potential to inhibit acetylcholinesterase and butyrylcholinesterase enzymes, the validated targets of Alzheimer's Disease. Therefore, within this research, a series of 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives has been designed, synthesized, and their biological activities were evaluated as potential acetylcholinesterase and butyrylcholinesterase inhibitors. The compounds synthesized exerted comparable activity in comparison to rivastigmine, galantamine, and donepezil both in in vitro and in vivo studies.

  20. Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors.

    PubMed

    Gulcan, Hayrettin Ozan; Unlu, Serdar; Esiringu, Ilker; Ercetin, Tugba; Sahin, Yasemin; Oz, Demet; Sahin, Mustafa Fethi

    2014-10-01

    Hydroxylated 6H-benzo[c]chromen-6-one derivatives (i.e., urolithins) are the main bioavailable metabolites, and biomarkers of ellagitannins present in various nutrition. Although these dietaries, the sources of urolithins, are employed in folk medicine as cognitive enhancer in the treatment of Alzheimer's Disease, urolithins have negligible potential to inhibit acetylcholinesterase and butyrylcholinesterase enzymes, the validated targets of Alzheimer's Disease. Therefore, within this research, a series of 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives has been designed, synthesized, and their biological activities were evaluated as potential acetylcholinesterase and butyrylcholinesterase inhibitors. The compounds synthesized exerted comparable activity in comparison to rivastigmine, galantamine, and donepezil both in in vitro and in vivo studies. PMID:25189690

  1. MELCOR 1.8.2 assessment: Aerosol experiments ABCOVE AB5, AB6, AB7, and LACE LA2

    SciTech Connect

    Souto, F.J.; Haskin, F.E.; Kmetyk, L.N.

    1994-10-01

    The MELCOR computer code has been used to model four of the large-scale aerosol behavior experiments conducted in the Containment System Test Facility (CSTF) vessel. Tests AB5, AB6 and AB7 of the ABCOVE program simulate the dry aerosol conditions during a hypothetical severe accident in an LMFBR. Test LA2 of the LACE program simulates aerosol behavior in a condensing steam environment during a postulated severe accident in an LWR with failure to isolate the containment. The comparison of code results to experimental data show that MELCOR is able to correctly predict most of the thermal-hydraulic results in the four tests. MELCOR predicts reasonably well the dry aerosol behavior of the ABCOVE tests, but significant disagreements are found in the aerosol behavior modelling for the LA2 experiment. These results tend to support some of the concerns about the MELCOR modelling of steam condensation onto aerosols expressed in previous works. During these analyses, a limitation in the MELCOR input was detected for the specification of the aerosol parameters for more than one component. A Latin Hypercube Sampling (LHS) sensitivity study of the aerosol dynamic constants is presented for test AB6. The study shows the importance of the aerosol shape factors in the aerosol deposition behavior, and reveals that MELCOR input/output processing is highly labor intensive for uncertainty and sensitivity analyses based on LHS.

  2. 26 CFR 1.585-8 - Rules for making and revoking elections under §§ 1.585-6 and 1.585-7.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Rules for making and revoking elections under §Â....585-8 Rules for making and revoking elections under §§ 1.585-6 and 1.585-7. (a) Time of making... made or revoked on or before February 28, 1994 and the making or revoking of the election results in...

  3. Design, Synthesis and Biological Evaluation of 5-Oxo-1,4,5,6,7,8 Hexahydroquinoline Derivatives as Selective Cyclooxygenase-2 Inhibitors

    PubMed Central

    Zarghi, Afshin; Sabakhi, Iman; Topuzyan, Vigen; Hajimahdi, Zahra; Daraie, Bahram

    2014-01-01

    A group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a COX-2 SO2Me pharmacophore at the para position of the C-2 or C-4 phenyl ring, in conjunction with a C-4 or C-2 phenyl (4-H) or substituted-phenyl ring (4-F,4-Cl,4-Br,4-OMe,4-Me, 4-NO2), were designed for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors. These target 5-oxo-1,4,5,6,7,8 hexahydroquinolines were synthesized via a Hansch condensation reaction. In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 7,8-dihydro- 7,7-dimethyl-2-(4-methoxyphenyl)-4-(4-(methylsulfonyl)phenyl)quinolin-5(1H,4H,6H)- one (9c) as a potent COX-2 inhibitor (IC50 = 0.17 M) with a high COX-2 selectivity index (S.I. = 97.6) comparable to the reference drug celecoxib (COX-2 IC50 = 0.05 mM; COX-2 S.I= 405). A molecular modeling study where 9c was docked in active site of COX-2 showed that the p-SO2Me substituent on the C-2 phenyl ring is inserted into the secondary COX-2 binding site. The structure activity data acquired indicate that the position of the COX-2 SO2Me pharmacophore and type of substituent are important for COX-2 inhibitory activity. PMID:24711830

  4. Transcription specificity of the class Ib genes SLA-6, SLA-7 and SLA-8 of the swine major histocompatibility complex and comparison with class Ia genes.

    PubMed

    Kusza, S; Flori, L; Gao, Y; Teillaud, A; Hu, R; Lemonnier, G; Bosze, Z; Bourneuf, E; Vincent-Naulleau, S; Rogel-Gaillard, C

    2011-10-01

    Our aim was to analyse the transcription levels of the three non-classical class Ib genes SLA-6, SLA-7 and SLA-8 of the swine major histocompatibility complex in various tissues and conditions and to compare them to the transcription levels of classical class Ia genes. Twenty-five adult tissues from two pig breeds, pig renal PK15 cells infected with the Pseudorabies virus, and peripheral blood mononuclear cells (PBMCs) stimulated by lipopolysaccharide or a mixture of phorbol myristate acetate and ionomycin were included in our study. Relative transcription was quantified by quantitative real-time PCR. On average, in adult tissues and PBMCs and compared to SLA-6, the transcription level of SLA-Ia genes was 100-1000 times higher, the level of SLA-8 was 10-20 times higher, and that of SLA-7 was five times higher. Thus, SLA-8 is the most transcribed SLA-Ib gene, followed by the SLA-7 and SLA-6 genes. The highest transcription levels of SLA-Ib transcripts were found in the lymphoid organs, followed by the lung and the digestive tract. The tissue variability of expression levels was widest for the SLA-6 gene, with a 1:32 ratio between the lowest and highest levels in contrast to a 1:12 ratio for the SLA-7 and SLA-8 genes and a 1:16 ratio for the SLA-Ia genes. During PK-15 infection and PBMC stimulation, SLA-Ia and SLA-8 genes were downregulated, whereas SLA-6 and SLA-7 were upregulated, downregulated or not significantly modified. Our overall results confirm the tissue-wide transcription of the three SLA-Ib genes and suggest that they have complementary roles.

  5. A novel technique for measurement of thermal rate constants and temperature dependences of dissociative recombination: CO2(+), CF3(+), N2O(+), C7H8(+), C7H7(+), C6H6(+), C6H5(+), C5H6(+), C4H4(+), and C3H3(+).

    PubMed

    Fournier, Joseph A; Shuman, Nicholas S; Melko, Joshua J; Ard, Shaun G; Viggiano, Albert A

    2013-04-21

    A novel technique using a flowing afterglow-Langmuir probe apparatus for measurement of temperature dependences of rate constants for dissociative recombination (DR) is presented. Low (~10(11) cm(-3)) concentrations of a neutral precursor are added to a noble gas∕electron afterglow plasma thermalized at 300-500 K. Charge exchange yields one or many cation species, each of which may undergo DR. Relative ion concentrations are monitored at a fixed reaction time while the initial plasma density is varied between 10(9) and 10(10) cm(-3). Modeling of the decrease in concentration of each cation relative to the non-recombining noble gas cation yields the rate constant for DR. The technique is applied to several species (O2(+), CO2(+), CF3(+), N2O(+)) with previously determined 300 K values, showing excellent agreement. The measurements of those species are extended to 500 K, with good agreement to literature values where they exist. Measurements are also made for a range of CnHm(+) (C7H7(+), C7H8(+), C5H6(+), C4H4(+), C6H5(+), C3H3(+), and C6H6(+)) derived from benzene and toluene neutral precursors. CnHm(+) DR rate constants vary from 8-12 × 10(-7) cm(3) s(-1) at 300 K with temperature dependences of approximately T(-0.7). Where prior measurements exist these results are in agreement, with the exception of C3H3(+) where the present results disagree with a previously reported flat temperature dependence. PMID:23614415

  6. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors.

    PubMed

    Asano, Shigehiro; Komiya, Masafumi; Koike, Nobuyuki; Koga, Erina; Nakatani, Shogo; Isobe, Yoshiaki

    2010-11-15

    A novel series of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines containing substituted phenyl sulfonamide are synthesized and evaluated for their inhibitory activity against CaMKII. Substituents on the phenyl group had significant impact on CaMKII inhibition, in particular, the inhibitory activity of 8p was 25-fold higher than that of KN-93, a known CaMKII inhibitor. Michaelis-Menten analysis of a representative compound suggested that the synthesized pyrimidines are calmodulin non-competitive inhibitors. Finally, 8p exhibited more than 100-fold higher selectivity for CaMKII over five types of off-target kinases. PMID:20875738

  7. X-ray Mapping in Heterocyclic Design: XIV. Tricyclic Heterocycles Based on 2-Oxo-1,2,5,6,7,8-Hexahydroquinoline-3-Carbonitrile

    SciTech Connect

    Mazina, O.S.; Rybakov, V.B.; Chernyshev, V.V.; Babaev, E.V.; Aslanov, L.A.

    2004-11-01

    The structures of four compounds are studied using single-crystal X-ray diffraction: 1-[2-(4-chlorophenyl)-2-oxoethyl]-2-oxo-1,2,5,6,7,8-hexahydroquinoline -3-carbonitrile [a = 4.908(4) A, b = 11.644(10) A, c = 13.587(2) A, {beta} = 94.31(5) deg., Z = 2, space group P2{sub 1}]; 2-[2-(4-chlorophenyl)-2-oxoethoxy]-5,6,7,8-tetrahydroquinoline -3-carbonitrile [a = 7.6142(8) A, b = 14.778(2) A, c = 14.132(2) A, {beta} = 100.38(1) deg., Z = 4, space group P2{sub 1}/c]; 4-(aminocarbonyl)-2-(chlorophenyl)-6,7,8,9-tetrahydro[1.3]oxazolo[3,2-a] quinolin-3-ium perchlorate [a = 5.589(7) A, b = 24.724(15) A, c = 13.727(5) A, {beta} = 97.66(9) deg., Z = 4, space group P2{sub 1}/n]; and (3-amino-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-2-yl)-(4-chlorophenyl) methanone [a = 7.150(2) A, b = 7.4288(10) A, c = 15.314(3) A, {alpha} = 98.030(10) deg., {beta} = 99.21(2) deg., {gamma} = 105.34(2) deg., Z = 2, space group P1-bar]. The structures are solved by direct methods and refined by the full-matrix least-squares procedure in the anisotropic approximation to R = 0.0728, 0.0439, 0.1228, and 0.0541, respectively. The structure of 1-(4-chlorophenyl)-4-piperidin-1-yl-8,9-dihydro-7H-pyrrolo[3.2.1-ij] quinoline-5-carboxamide [a = 23.9895(9) A, b = 5.1557(3) A, c = 17.0959(9) A, {beta} = 106.43 deg., Z = 4, space group P{sub 1}/c] is investigated by X-ray powder diffraction. This structure is solved using the grid search procedure and refined by the Rietveld method to R{sub wp} = 0.0773, R{sub exp} = 0.0540, R{sub p} = 0.0585, R{sub b} = 0.1107, and {chi}{sup 2} = 1.78.

  8. Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application.

    PubMed

    Waidyanatha, Suramya; Ryan, Kristen

    2014-08-01

    1. Disposition of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (β-OTNE), a fragrance ingredient in variety of consumer products, was investigated following a single oral (20 mg/kg) or a dermal (55 or 550 mg/kg) dose of [(14)C]β-OTNE to male Fisher rats. 2. Following oral administration, 28% and 39% of the dose was recovered in urine and feces, respectively, 48 h following administration. About 73% of a 20 mg/kg dose was excreted in bile within 48 h post-administration supporting significant oral absorption of [(14)C]β-OTNE. 3. Following dermal application to a covered site, absorption of [(14)C]β-OTNE 96 h following application was low (ca. 14%) and dose-independent. When the dose site was uncovered, the absorption increased to ca. 33% (55 mg/kg) and ca. 72% (550 mg/kg). 4. [(14)C]β-OTNE was distributed to tissues following both routes of exposure with the highest radioactive equivalents found in bladder, liver, kidney, adipose and pancreas. 5. Elimination of [(14)C]β-OTNE equivalents in blood and tissues was slow following both oral and dermal application suggesting potential for accumulation following multiple exposure. PMID:24533629

  9. Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application.

    PubMed

    Waidyanatha, Suramya; Ryan, Kristen

    2014-08-01

    1. Disposition of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (β-OTNE), a fragrance ingredient in variety of consumer products, was investigated following a single oral (20 mg/kg) or a dermal (55 or 550 mg/kg) dose of [(14)C]β-OTNE to male Fisher rats. 2. Following oral administration, 28% and 39% of the dose was recovered in urine and feces, respectively, 48 h following administration. About 73% of a 20 mg/kg dose was excreted in bile within 48 h post-administration supporting significant oral absorption of [(14)C]β-OTNE. 3. Following dermal application to a covered site, absorption of [(14)C]β-OTNE 96 h following application was low (ca. 14%) and dose-independent. When the dose site was uncovered, the absorption increased to ca. 33% (55 mg/kg) and ca. 72% (550 mg/kg). 4. [(14)C]β-OTNE was distributed to tissues following both routes of exposure with the highest radioactive equivalents found in bladder, liver, kidney, adipose and pancreas. 5. Elimination of [(14)C]β-OTNE equivalents in blood and tissues was slow following both oral and dermal application suggesting potential for accumulation following multiple exposure.

  10. Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

    PubMed

    Dennis, Matthew L; Chhabra, Sandeep; Wang, Zhong-Chang; Debono, Aaron; Dolezal, Olan; Newman, Janet; Pitcher, Noel P; Rahmani, Raphael; Cleary, Ben; Barlow, Nicholas; Hattarki, Meghan; Graham, Bim; Peat, Thomas S; Baell, Jonathan B; Swarbrick, James D

    2014-11-26

    6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), an enzyme from the folate biosynthesis pathway, catalyzes the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin and is a yet-to-be-drugged antimicrobial target. Building on our previous discovery that 8-mercaptoguanine (8MG) is an inhibitor of Staphylococcus aureus HPPK (SaHPPK), we have identified and characterized the binding of an S8-functionalized derivative (3). X-ray structures of both the SaHPPK/3/cofactor analogue ternary and the SaHPPK/cofactor analogue binary complexes have provided insight into cofactor recognition and key residues that move over 30 Å upon binding of 3, whereas NMR measurements reveal a partially plastic ternary complex active site. Synthesis and binding analysis of a set of analogues of 3 have identified an advanced new lead compound (11) displaying >20-fold higher affinity for SaHPPK than 8MG. A number of these exhibited low micromolar affinity for dihydropteroate synthase (DHPS), the adjacent, downstream enzyme to HPPK, and may thus represent promising new leads to bienzyme inhibitors. PMID:25357262

  11. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. [Tetrahydropyrene and hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H[sub 2] hydrogenation reaction network.

  12. 7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.

    PubMed

    D'Erasmo, Michael P; Smith, William B; Munoz, Alberto; Mohandas, Poornima; Au, Andrew S; Marineau, Jason J; Quadri, Luis E N; Bradner, James E; Murelli, Ryan P

    2014-08-15

    7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic butenolides that can be generated rapidly and as a single diastereomer through a cascade process between γ-hydroxybutenolides and aromatic aldehydes. The following outlines our findings that these spirocycles are potently cytotoxic and have a dramatic structure-function profile that provides excellent insight into the structural features required for this potency.

  13. COMPARISON OF OVERALL METABOLISM OF 1, 2, 7, 8-PECDD IN CYP1A2(-L-) KNOCKOUT AND C57BL/6N PARENTAL STRAINS OF MICE

    EPA Science Inventory

    COMPARISON OF OVERALL METABOLISM OF 1,2,3,7,8-PeCDD
    IN CYP1A2 (-/-) KNOCKOUT AND C57BL/6N PARENTAL
    STRAINS OF MICE

    Heldur Hakk1 and Janet J. Diliberto2

    1 USDA-ARS, Biosciences Research Laboratory, P.O. Box 5674, Fargo, ND, USA
    2 US EPA, ORD, National Heal...

  14. Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells.

    PubMed

    Wade, N; Bryant, N J; Connolly, L M; Simpson, R J; Luzio, J P; Piper, R C; James, D E

    2001-06-01

    Syntaxin 7 is a mammalian target soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) involved in membrane transport between late endosomes and lysosomes. The aim of the present study was to use immunoaffinity techniques to identify proteins that interact with Syntaxin 7. We reasoned that this would be facilitated by the use of cells producing high levels of Syntaxin 7. Screening of a large number of tissues and cell lines revealed that Syntaxin 7 is expressed at very high levels in B16 melanoma cells. Moreover, the expression of Syntaxin 7 increased in these cells as they underwent melanogenesis. From a large scale Syntaxin 7 immunoprecipitation, we have identified six polypeptides using a combination of electrospray mass spectrometry and immunoblotting. These polypeptides corresponded to Syntaxin 7, Syntaxin 6, mouse Vps10p tail interactor 1b (mVti1b), alpha-synaptosome-associated protein (SNAP), vesicle-associated membrane protein (VAMP)8, VAMP7, and the protein phosphatase 1M regulatory subunit. We also observed partial colocalization between Syntaxin 6 and Syntaxin 7, between Syntaxin 6 and mVti1b, but not between Syntaxin 6 and the early endosomal t-SNARE Syntaxin 13. Based on these and data reported previously, we propose that Syntaxin 7/mVti1b/Syntaxin 6 may form discrete SNARE complexes with either VAMP7 or VAMP8 to regulate fusion events within the late endosomal pathway and that these events may play a critical role in melanogenesis.

  15. A spiro[chroman-3,7'-isochromene]-4,6'(8'H)-dione from the Cordyceps-colonizing fungus Fimetariella sp.

    PubMed

    Li, Erwei; Zhang, Fan; Niu, Shubin; Liu, Xingzhong; Liu, Gang; Che, Yongsheng

    2012-07-01

    Fimetarone A (1), a metabolite with the new spiro[chroman-3,7'-isochromene]-4,6'(8'H)-dione skeleton, was isolated from cultures of the Cordyceps-colonizing fungus Fimetariella sp. Compound 1 was a 1:1 atropdiastereomeric mixture in NMR data, and aS,9S and aR,9R enantiomers were found and confirmed by X-ray crystallography. Compound 1 could be derived from the hypothetical precursors 3,4,5-trihydroxy-2-(2-methylene-3,5-dioxohexanoyl)benzoic acid (5) and lapidosin (6). PMID:22726106

  16. (9E)-9-benzylidene-2-methylsulfanyl-5-phenyl-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one: a hydrogen-bonded R2(2)(8) dimer.

    PubMed

    Becerra, Diana; Insuasty, Braulio; Cobo, Justo; Glidewell, Christopher

    2013-12-15

    In the molecule of the title compound, C25H21N3OS, which was prepared by mild oxidation of the corresponding 5,6,7,8,9,10-hexahydro analogue, the fused carbocyclic ring adopts an envelope conformation. Pairs of molecules are linked into cyclic centrosymmetric dimers by pairs of inversion-related N-H···O hydrogen bonds.

  17. Clade 8 and Clade 6 Strains of Escherichia coli O157:H7 from Cattle in Argentina have Hypervirulent-Like Phenotypes.

    PubMed

    Amigo, Natalia; Mercado, Elsa; Bentancor, Adriana; Singh, Pallavi; Vilte, Daniel; Gerhardt, Elisabeth; Zotta, Elsa; Ibarra, Cristina; Manning, Shannon D; Larzábal, Mariano; Cataldi, Angel

    2015-01-01

    The hemolytic uremic syndrome (HUS) whose main causative agent is enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a disease that mainly affects children under 5 years of age. Argentina is the country with the highest incidence of HUS in the world. Cattle are a major reservoir and source of infection with E. coli O157:H7. To date, the epidemiological factors that contribute to its prevalence are poorly understood. Single nucleotide polymorphism (SNP) typing has helped to define nine E. coli O157:H7 clades and the clade 8 strains were associated with most of the cases of severe disease. In this study, eight randomly selected isolates of EHEC O157:H7 from cattle in Argentina were studied as well as two human isolates. Four of them were classified as clade 8 through the screening for 23 SNPs; the two human isolates grouped in this clade as well, while two strains were closely related to strains representing clade 6. To assess the pathogenicity of these strains, we assayed correlates of virulence. Shiga toxin production was determined by an ELISA kit. Four strains were high producers and one of these strains that belonged to a novel genotype showed high verocytotoxic activity in cultured cells. Also, these clade 8 and 6 strains showed high RBC lysis and adherence to epithelial cells. One of the clade 6 strains showed stronger inhibition of normal water absorption than E. coli O157:H7 EDL933 in human colonic explants. In addition, two of the strains showing high levels of Stx2 production and RBC lysis activity were associated with lethality and uremia in a mouse model. Consequently, circulation of such strains in cattle may partially contribute to the high incidence of HUS in Argentina.

  18. Clade 8 and Clade 6 Strains of Escherichia coli O157:H7 from Cattle in Argentina have Hypervirulent-Like Phenotypes

    PubMed Central

    Amigo, Natalia; Mercado, Elsa; Bentancor, Adriana; Singh, Pallavi; Vilte, Daniel; Gerhardt, Elisabeth; Zotta, Elsa; Ibarra, Cristina; Manning, Shannon D.; Larzábal, Mariano; Cataldi, Angel

    2015-01-01

    The hemolytic uremic syndrome (HUS) whose main causative agent is enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a disease that mainly affects children under 5 years of age. Argentina is the country with the highest incidence of HUS in the world. Cattle are a major reservoir and source of infection with E. coli O157:H7. To date, the epidemiological factors that contribute to its prevalence are poorly understood. Single nucleotide polymorphism (SNP) typing has helped to define nine E. coli O157:H7 clades and the clade 8 strains were associated with most of the cases of severe disease. In this study, eight randomly selected isolates of EHEC O157:H7 from cattle in Argentina were studied as well as two human isolates. Four of them were classified as clade 8 through the screening for 23 SNPs; the two human isolates grouped in this clade as well, while two strains were closely related to strains representing clade 6. To assess the pathogenicity of these strains, we assayed correlates of virulence. Shiga toxin production was determined by an ELISA kit. Four strains were high producers and one of these strains that belonged to a novel genotype showed high verocytotoxic activity in cultured cells. Also, these clade 8 and 6 strains showed high RBC lysis and adherence to epithelial cells. One of the clade 6 strains showed stronger inhibition of normal water absorption than E. coli O157:H7 EDL933 in human colonic explants. In addition, two of the strains showing high levels of Stx2 production and RBC lysis activity were associated with lethality and uremia in a mouse model. Consequently, circulation of such strains in cattle may partially contribute to the high incidence of HUS in Argentina. PMID:26030198

  19. Clade 8 and Clade 6 Strains of Escherichia coli O157:H7 from Cattle in Argentina have Hypervirulent-Like Phenotypes.

    PubMed

    Amigo, Natalia; Mercado, Elsa; Bentancor, Adriana; Singh, Pallavi; Vilte, Daniel; Gerhardt, Elisabeth; Zotta, Elsa; Ibarra, Cristina; Manning, Shannon D; Larzábal, Mariano; Cataldi, Angel

    2015-01-01

    The hemolytic uremic syndrome (HUS) whose main causative agent is enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a disease that mainly affects children under 5 years of age. Argentina is the country with the highest incidence of HUS in the world. Cattle are a major reservoir and source of infection with E. coli O157:H7. To date, the epidemiological factors that contribute to its prevalence are poorly understood. Single nucleotide polymorphism (SNP) typing has helped to define nine E. coli O157:H7 clades and the clade 8 strains were associated with most of the cases of severe disease. In this study, eight randomly selected isolates of EHEC O157:H7 from cattle in Argentina were studied as well as two human isolates. Four of them were classified as clade 8 through the screening for 23 SNPs; the two human isolates grouped in this clade as well, while two strains were closely related to strains representing clade 6. To assess the pathogenicity of these strains, we assayed correlates of virulence. Shiga toxin production was determined by an ELISA kit. Four strains were high producers and one of these strains that belonged to a novel genotype showed high verocytotoxic activity in cultured cells. Also, these clade 8 and 6 strains showed high RBC lysis and adherence to epithelial cells. One of the clade 6 strains showed stronger inhibition of normal water absorption than E. coli O157:H7 EDL933 in human colonic explants. In addition, two of the strains showing high levels of Stx2 production and RBC lysis activity were associated with lethality and uremia in a mouse model. Consequently, circulation of such strains in cattle may partially contribute to the high incidence of HUS in Argentina. PMID:26030198

  20. 7 CFR 295.8 - Requests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Requests. 295.8 Section 295.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Regulations 7 CFR 1.6 and addressed to the appropriate FNS official listed below: (1) Food Stamp...

  1. 7 CFR 295.8 - Requests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Requests. 295.8 Section 295.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Regulations 7 CFR 1.6 and addressed to the appropriate FNS official listed below: (1) Food Stamp...

  2. 7 CFR 295.8 - Requests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Requests. 295.8 Section 295.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Regulations 7 CFR 1.6 and addressed to the appropriate FNS official listed below: (1) Food Stamp...

  3. 7 CFR 295.8 - Requests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Requests. 295.8 Section 295.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Regulations 7 CFR 1.6 and addressed to the appropriate FNS official listed below: (1) Food Stamp...

  4. 7 CFR 295.8 - Requests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Requests. 295.8 Section 295.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Regulations 7 CFR 1.6 and addressed to the appropriate FNS official listed below: (1) Food Stamp...

  5. Escherichia coli 6-pyruvoyltetrahydropterin synthase ortholog encoded by ygcM has a new catalytic activity for conversion of sepiapterin to 7,8-dihydropterin.

    PubMed

    Woo, Hyun Joo; Hwang, Yoon Kyung; Kim, Yeon Jung; Kang, Jee Yun; Choi, Yong Kee; Kim, Chun Gyu; Park, Young Shik

    2002-07-17

    The putative gene (ygcM) of Escherichia coli was verified in vitro to encode the ortholog of 6-pyruvoyltetrahydropterin synthase (PTPS). Unexpectedly, the enzyme was found to convert sepiapterin to 7,8-dihydropterin without any cofactors. The enzymatic product 7,8-dihydropterin was identified by HPLC and mass spectrometry analyses, suggesting a novel activity of the enzyme to cleave the C6 side chain of sepiapterin. The optimal activity occurred at pH 6.5-7.0. The reaction rate increased up to 3.2-fold at 60-80 degrees C, reflecting the thermal stability of the enzyme. The reaction required no metal ion and was activated slightly by low concentrations (1-5 mM) of EDTA. The apparent K(m) value for sepiapterin was determined as 0.92 mM and the V(max) value was 151.3 nmol/min/mg. The new catalytic function of E. coli PTPS does not imply any physiological role, because sepiapterin is not an endogenous substrate of the organism. The same activity, however, was also detected in a PTPS ortholog of Synechocystis sp. PCC 6803 but not significant in Drosophila and human enzymes, suggesting that the activity may be prevalent in bacterial PTPS orthologs.

  6. Thermodynamic stability of the molecules YC2, YC3, YC4, YC5, YC6, YC7, and YC8 by high temperature Knudsen effusion mass spectrometry

    NASA Astrophysics Data System (ADS)

    Pelino, Mario; Haque, R.; Bencivenni, L.; Gingerich, K. A.

    1988-05-01

    The molecules YC2, YC3, YC4, YC5, YC6, YC7, and YC8 have been observed in a Knudsen effusion mass spectrometric investigation of the gas phase above the Y-Ir-Au-graphite system. The enthalpies ΔH○0 of the reactions Y(g)+n C(graph)=YCn(g)(n=2-8) were evaluated by the third law method; the second law method was employed for the gaseous molecules with up to six carbon atoms. The selected values of the reaction enthalpies ΔH○0 were combined with ancillary literature data to yield the atomization enthalpies ΔH○a,0 and the standard enthalpies of formation ΔH○f,298.15 in kJ mol-1 of the gaseous yttrium carbides. The values of ΔH○0 and ΔH○a,0 (in kJ mol-1) are 197±5 and 1225±8 for YC2; 377±10 and 1757±12 for YC3; 361±8 and 2484±10 for YC4; 499±10 and 3057±15 for YC5; 536±15 and 3731±20 for YC6; 684±35 and 4294±35 for YC7, and 693±35 and 4727±35 for YC8. The values of ΔH○f,298.15 (in kJ mol-1) are 623±8, 804±12, 790±10, 924±15, 966±20, 1105±35, and 1124±35 for YCn (n=2-8), respectively.

  7. Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity

    PubMed Central

    Chen, Yi-Fong; Lin, Yi-Chien; Morris-Natschke, Susan L; Wei, Chen-Fang; Shen, Ting-Chen; Lin, Hui-Yi; Hsu, Mei-Hua; Chou, Li-Chen; Zhao, Yu; Kuo, Sheng-Chu; Lee, Kuo-Hsiung; Huang, Li-Jiau

    2015-01-01

    Background and Purpose 4-Phenylquinolin-2(1H)-one (4-PQ) derivatives can induce cancer cell apoptosis. Additional new 4-PQ analogs were investigated as more effective, less toxic antitumour agents. Experimental Approach Forty-five 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives were synthesized. Antiproliferative activities were evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliun bromide assay and structure–activity relationship correlations were established. Compounds 9b, 9c, 9e and 11e were also evaluated against the National Cancer Institute-60 human cancer cell line panel. Hoechst 33258 and Annexin V-FITC/PI staining assays were used to detect apoptosis, while inhibition of microtubule polymerization was assayed by fluorescence microscopy. Effects on the cell cycle were assessed by flow cytometry and on apoptosis-related proteins (active caspase-3, -8 and -9, procaspase-3, -8, -9, PARP, Bid, Bcl-xL and Bcl-2) by Western blotting. Key Results Nine 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives (7e, 8e, 9b, 9c, 9e, 10c, 10e, 11c and 11e) displayed high potency against HL-60, Hep3B, H460, and COLO 205 cancer cells (IC50 < 1 μM) without affecting Detroit 551 normal human cells (IC50 > 50 μM). Particularly, compound 11e exhibited nanomolar potency against COLO 205 cancer cells. Mechanistic studies indicated that compound 11e disrupted microtubule assembly and induced G2/M arrest, polyploidy and apoptosis via the intrinsic and extrinsic signalling pathways. Activation of JNK could play a role in TRAIL-induced COLO 205 apoptosis. Conclusion and Implications New quinolone derivatives were identified as potential pro-apoptotic agents. Compound 11e could be a promising lead compound for future antitumour agent development. PMID:25363404

  8. [Regulation of the activity and synthesis of enzymes participating in the formation of 6,7-dimethyl-8-ribityllumazine, a riboflavin precursor in yeast].

    PubMed

    Logvinenko, E M; Shavlovskiĭ, G M; Zakal'skiĭ, A E; Samarskiĭ, V A

    1989-01-01

    The properties of two flavinogenesis enzymes--synthase of the aliphatic precursor of riboflavin (APR-synthase) and 6.7-dimethyl-8-ribityllumazinesynthase (DMRL-synthase) of Pichia guilliermondii. It is established that DMRL-synthase, uses APR as a substrate which contains, evidently, a phosphate group. The value of Km for APR is equal to 0.7.10(-5) M, for 2.4-dihydroxy-5-amino-6-ribitylaminopyrimidine--1.25.10(-5) M. It is riboflavin but not FAD that inhibits the activity of DMRL-synthase; the value (I)0.5 is equal to 2.10(-5) M. DMRL, riboflavin, flavin mononucleotide and FAD do not affect the APR-synthase activity. In iron-deficient cells of P. guilliermondii, Torulopsis candida, Debaryomyces klöckeri and Schwanniomyces occidentalis realizing the oversynthesis of riboflavin there occurs derepression of DMRL-synthase and APR-synthase. PMID:2741238

  9. [Regulation of the activity and synthesis of enzymes participating in the formation of 6,7-dimethyl-8-ribityllumazine, a riboflavin precursor in yeast].

    PubMed

    Logvinenko, E M; Shavlovskiĭ, G M; Zakal'skiĭ, A E; Samarskiĭ, V A

    1989-01-01

    The properties of two flavinogenesis enzymes--synthase of the aliphatic precursor of riboflavin (APR-synthase) and 6.7-dimethyl-8-ribityllumazinesynthase (DMRL-synthase) of Pichia guilliermondii. It is established that DMRL-synthase, uses APR as a substrate which contains, evidently, a phosphate group. The value of Km for APR is equal to 0.7.10(-5) M, for 2.4-dihydroxy-5-amino-6-ribitylaminopyrimidine--1.25.10(-5) M. It is riboflavin but not FAD that inhibits the activity of DMRL-synthase; the value (I)0.5 is equal to 2.10(-5) M. DMRL, riboflavin, flavin mononucleotide and FAD do not affect the APR-synthase activity. In iron-deficient cells of P. guilliermondii, Torulopsis candida, Debaryomyces klöckeri and Schwanniomyces occidentalis realizing the oversynthesis of riboflavin there occurs derepression of DMRL-synthase and APR-synthase.

  10. Racemic tricarbonyl[(4a,5,6,7,8,8a-η)-2-phenyl-3,4-dihydro-2H-1-benzopyran]chromium(0)

    PubMed Central

    van Tonder, Johannes H.; Bezuidenhoudt, Barend C. B.; Janse van Rensburg, J. Marthinus

    2010-01-01

    The title compound, [Cr(C15H14O)(CO)3], displays a distorted envelope configuration of the dihydro­pyrane ring. The dihedral angle between the phenyl and phenyl­ene rings is 50.63 (4)°. The Cr0 atom is coordinated by three CO groups and the phenyl­ene ring of the flavan ligand in an η6 mode, with a common arene-to-metal distance PMID:21588503

  11. 7 CFR 624.8 - Assistance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Assistance. 624.8 Section 624.8 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES EMERGENCY WATERSHED PROTECTION § 624.8 Assistance. (a) Sponsors must submit...

  12. 7 CFR 624.8 - Assistance.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Assistance. 624.8 Section 624.8 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES EMERGENCY WATERSHED PROTECTION § 624.8 Assistance. (a) Sponsors must submit...

  13. 7 CFR 623.8 - Easement value.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Easement value. 623.8 Section 623.8 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES EMERGENCY WETLANDS RESERVE PROGRAM § 623.8 Easement value. NRCS offers...

  14. Global emission estimates and radiative impact of C4F10, C5F12, C6F14, C7F16 and C8F18

    NASA Astrophysics Data System (ADS)

    Ivy, D. J.; Rigby, M.; Baasandorj, M.; Burkholder, J. B.; Prinn, R. G.

    2012-08-01

    Global emission estimates based on new atmospheric observations are presented for the acylic high molecular weight perfluorocarbons (PFCs): decafluorobutane (C4F10), dodecafluoropentane (C5F12), tetradecafluorohexane (C6F14), hexadecafluoroheptane (C7F16) and octadecafluorooctane (C8F18). Emissions are estimated using a 3-dimensional chemical transport model and an inverse method that includes a growth constraint on emissions. The observations used in the inversion are based on newly measured archived air samples that cover a 39-yr period, from 1973 to 2011, and include 36 Northern Hemispheric and 46 Southern Hemispheric samples. The derived emission estimates show that global emission rates were largest in the 1980s and 1990s for C4F10 and C5F12, and in the 1990s for C6F14, C7F16 and C8F18. After a subsequent decline, emissions have remained relatively stable, within 20%, for the last 5 yr. Bottom-up emission estimates are available from the Emission Database for Global Atmospheric Research version 4.2 (EDGARv4.2) for C4F10, C5F12, C6F14 and C7F16, and inventories of C4F10, C5F12 and C6F14 are reported to the United Nations' Framework Convention on Climate Change (UNFCCC) by Annex 1 countries that have ratified the Kyoto Protocol. The atmospheric measurement-based emission estimates are 20 times larger than EDGARv4.2 for C4F10 and over three orders of magnitude larger for C5F12 (with 2008 EDGARv4.2 estimates for C5F12 at 9.6 kg yr-1, as compared to 67±53 t yr-1 as derived in this study). The derived emission estimates for C6F14 largely agree with the bottom-up estimates from EDGARv4.2. Moreover, the C7F16 emission estimates are comparable to those of EDGARv4.2 at their peak in the 1990s, albeit significant underestimation for the other time periods. There are no bottom-up emission estimates for C8F18, thus the emission rates reported here are the first for C8F18. The reported inventories for C4F10, C5F12 and C6F14 to UNFCCC are five to ten times lower than those

  15. 3,6-Dimethoxy-6″,6″-Dimethyl-(7,8,2″,3″)-Chromeneflavone, a Flavonoid Isolated from Lonchocarpus Araripensis Benth. (Fabaceae), Reduces Nociceptive Behaviour in Mice.

    PubMed

    Almeida, Jackson R G S; Silva, Juliane C; Guimarães, Amanda L; Oliveira, Ana P; Souza, Grasielly R; Oliveira-Júnior, Raimundo G; Lima-Saraiva, Sarah R G; Barbosa-Filho, José M; Braz-Filho, Raimundo; Queiroz, Dinalva Brito; Botelho, Marco Antônio

    2015-10-01

    Lonchocarpus araripensis Benth. is largely distributed in the northeast region of Brazil. It is popularly known as 'sucupira'. Recent studies have shown that some species of Lonchocarpus have interesting pharmacological activities. In this study, we evaluated the antinociceptive effect of a flavone isolated from L. araripensis. The chemical examination resulted in the isolation of 3,6-dimethoxy-6″,6″-dimethyl-(7,8,2″,3″)-chromeneflavone (DDF). The structure of the compound was established by spectral analysis. Antinociceptive activity of DDF was evaluated by measuring nociception by acetic acid, formalin and hot plate tests. The rota rod test was used to evaluate motor coordination. The results demonstrated that DDF was able to prevent acetic-acid-writhing-induced nociception (p < 0.001) in mice. Furthermore, DDF produced a significant reduction of the nociceptive behaviour at the early and late phases of paw licking in the formalin test. Also, DDF produced an inhibition of the nociceptive behaviour during a hot-plate test. No alteration in motor coordination was observed. These results confirm the hypothesis that DDF reduces the nociceptive behaviour in mice, probably through central mechanisms, but without compromising the motor coordination of animals.

  16. Global emission estimates and radiative impact of C4F10, C5F12, C6F14, C7F16 and C8F18

    NASA Astrophysics Data System (ADS)

    Ivy, D. J.; Rigby, M.; Baasandorj, M.; Burkholder, J. B.; Prinn, R. G.

    2012-05-01

    Global emission estimates based on new atmospheric observations are presented for the acylic high molecular weight perfluorocarbons (PFCs): decafluorobutane (C4F10), dodecafluoropentane (C5F12), tetradecafluorohexane (C6F14), hexadecafluoroheptane (C7F16) and octadecafluorooctane (C8F18). Emissions are estimated using a 3-dimensional chemical transport model and an inverse method that includes a growth constraint on emissions. The observations used in the inversion are based on newly measured archived air samples that cover a 39-yr period, from 1973 to 2011, and include 36 Northern Hemispheric and 46 Southern Hemispheric samples (Ivy et al., 2012). The derived emission estimates show that global emission rates were largest in the 1980s and 1990s for C4F10 and C5F12, and in the 1990s for C6F14,C7F16 and C8F18. After a subsequent decline, emissions have remained relatively stable, within 20%, for the last 5 yr. Bottom-up emission estimates are available from the Emission Database for Global Atmospheric Research version 4.2 (EDGARv4.2) for C4F10, C5F12, C6F14 and C7F16, and inventories of C4F10, C5F12 andC6F14 are reported to the United Nations' Framework Convention on Climate Change (UNFCCC) by Annex 1 countries that have ratified the Kyoto Protocol. The atmospheric measurement based emission estimates are 20 times larger than EDGARv4.2 for C4F10 and over three orders of magnitude for C5F12. The derived emission estimates for C6F14 largely agree with the bottom-up estimates from EDGARv4.2. Moreover, the C7F16 emission estimates are comparable to those of EDGARv4.2 at their peak in the 1990s, albeit significant underestimation for the other time periods. There are no bottom-up emission estimates for C8F18, thus the emission rates reported here are the first for C8F18. The reported inventories for C4F10, C5F12 and C6F14 to UNFCCC are five to ten times lower than those estimated in this study. In addition, we present measured infrared absorption spectra for C7F16 and C8

  17. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8O Methyl phenyl ether (VMSD1111, LB4823_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8O Methyl phenyl ether (VMSD1111, LB4823_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  18. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8 Toluene (VMSD1511, LB4831_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8 Toluene (VMSD1511, LB4831_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  19. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8O Methyl phenyl ether (VMSD1511, LB4833_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8O Methyl phenyl ether (VMSD1511, LB4833_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  20. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8 Toluene (VMSD1111, LB4820_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8 Toluene (VMSD1111, LB4820_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  1. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8 Toluene (VMSD1212, LB4826_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8 Toluene (VMSD1212, LB4826_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  2. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8O Methyl phenyl ether (VMSD1212, LB4828_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C7H8O Methyl phenyl ether (VMSD1212, LB4828_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  3. Synthesis and Application of 1,3,4,5,7,8-Hexafluorotetracyanonaphthoquinodimethane (F6-TNAP): A Conductivity Dopant for Organic Light-Emitting Devices

    SciTech Connect

    Koech, Phillip K.; Padmaperuma, Asanga B.; Wang, Liang; Swensen, James S.; Polikarpov, Evgueni; Darsell, Jens T.; Rainbolt, James E.; Gaspar, Daniel J.

    2010-07-13

    We report the synthesis, photophysical and organic light-emitting device (OLED) properties of an organic molecular p-dopant 1,3,4,5,7,8-hexafluorotetracyanonaphthoquinodimethane (F6-TNAP). F6-TNAP was obtained in a three step 2 pot synthesis from commercially available octafluoronaphthalene. Doping effect of F6-TNAP was evaluated using films of 1-5% F6-TNAP with N,N'-di-1-naphthyl-N,N'-diphenyl-1,1'-biphenyl-4,4'diamineα-NPD) co-evaporated on quartz. UV-vis analysis of these films showed an absorption peak at 950 nm corresponding to the charge transfer complex resulting from electron transfer from α-NPD to F6-TNAP. Hole only devices using α-NPD as the hole transport layer (HTL) doped with F6-TNAP show greater than 2V decrease in operating voltage compared to the undoped device. A decrease in operating voltage was also demonstrated in blue OLED devices using F6-TNAP doped HTL, with a slight decrease in external quantum efficiency (EQE), thus resulting in a net improvement in power efficiency.

  4. Suppression of Human B Cell Activation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Involves Altered Regulation of B Cell Lymphoma-6

    PubMed Central

    Phadnis-Moghe, Ashwini S.; Crawford, Robert B.; Kaminski, Norbert E.

    2015-01-01

    The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces marked suppression of the primary humoral immune response in virtually every animal species evaluated thus far. In addition, epidemiological studies performed in areas of dioxin contamination have identified an association between TCDD exposure and an increased incidence of non-Hodgkin’s lymphoma (NHL). Recent studies using an in vitro CD40 ligand model of human B cell differentiation have shown that TCDD impairs both B cell activation and differentiation. The present study extends these findings by identifying B cell lymphoma-6 [BCL-6] as a putative cellular target for deregulation by TCDD, which may contribute to suppression of B cell function as well as NHL. BCL-6 is a multifunctional transcriptional repressor frequently mutated in NHLs and known to regulate critical events of B cell activation and differentiation. In the presence of TCDD, BCL-6 protein levels were elevated and concurrently the same population of cells with high BCL-6 levels showed decreased CD80 and CD69 expression indicative of impaired cellular activation. The elevated BCL-6 levels resulted in a concomitant increase in BCL-6 DNA binding activity at its cognate binding site within an enhancer region for CD80. Furthermore, a small molecule inhibitor of BCL-6 activity reversed TCDD-mediated suppression of CD80 expression in human B cells. In the presence of a low-affinity ligand of the aryl hydrocarbon receptor (AHR), suppression of B cell activation and altered BCL-6 regulation were not observed. These results provide new mechanistic insights into the role of BCL-6 in the suppression of human B cell activation by TCDD. PMID:25543051

  5. Ring Puckering Potentials of Three Fluorinated Cyclopentenes: C_5F_8, C_5HF_7, and C_5H_2F_6

    NASA Astrophysics Data System (ADS)

    Arsenault, E. A.; Long, B. E.; Pringle, Wallace C.; Choi, Yoon Jeong; Cooke, S. A.; Ocola, Esther J.; Laane, Jaan

    2015-06-01

    A systematic study on the ring puckering potentials of three fluorinated cyclopentenes has been performed using Fourier transform microwave spectroscopy in tandem with quantum chemical calculations. Spectra between 8 GHz and 16 GHz have been measured for octafluorocyclopentene, 1H-heptafluorocyclopentene, and 1H,2H-hexafluorocyclopentene, where the hydrogens sequentially replace the fluorines on the sp^2 hybridized carbons. Rotational constants and centrifugal distortion constants have been determined for the parent species and all 13C isotopologues. In regards to the ring puckering, double minimum potential, both cross state and intra-state transitions were observed for all molecules except the 1H,2H-hexafluorocyclopentene. Experimental Coriolis coupling constants and ΔE01 values will be presented and discussed. The ring puckering barrier heights for C_5F_8, C_5HF_7, and C_5H_2F_6, have been calculated to be 222 wn, 302 wn, and 367 wn, respectively.

  6. Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors

    PubMed Central

    Antczak, Christophe; Veach, Darren R.; Ramirez, Christina N.; Minchenko, Maria A.; Shum, David; Calder, Paul A.; Frattini, Mark G.; Clarkson, Bayard; Djaballah, Hakim

    2013-01-01

    We report the design, synthesis and structure-activity relationship (SAR) of a series of novel pyrido[2,3-d]pyrimidin-7-one compounds as potent Abl kinase inhibitors. We evaluate their specificity profile against a panel of human recombinant kinases, as well as their biological profile toward a panel of well characterized cancer cell lines. Our study reveals that substitutions in the -3 and -4 positions of the phenylamino moiety lead to improved potency and improved selectivity both in target-based and cell based assays. Altogether, our results provide an insight into the SAR of pyrido[2,3-d]pyrimidin-7-ones for the development of drug candidates with improved potency and selectivity for the targeted treatment of CML. PMID:19889540

  7. Structure and Activity of Yersinia pestis 6-hydroxymethyl-7,8-dihydropterin Pyrophosphokinase as a Novel Target for the Development of Antiplague Therapeutics

    SciTech Connect

    Blaszczyk,J.; Li, Y.; Cherry, S.; Alexandratos, J.; Wu, Y.; Shaw, G.; Tropea, J.; Waugh, D.; Yan, H.; Ji, X.

    2007-01-01

    6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is a key enzyme in the folate-biosynthetic pathway and is essential for microorganisms but absent from mammals. HPPK catalyzes Mg2+-dependent pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). Previously, three-dimensional structures of Escherichia coli HPPK (EcHPPK) have been determined at almost every stage of its catalytic cycle and the reaction mechanism has been established. Here, the crystal structure of Yersinia pestis HPPK (YpHPPK) in complex with HP and an ATP analog is presented together with thermodynamic and kinetic characterizations. The two HPPK molecules differ significantly in a helix-loop area ([alpha]2-Lp3). YpHPPK has lower affinities than EcHPPK for both nucleotides and HP, but its rate constants for the mechanistic steps of both chemical transformation and product release are comparable with those of EcHPPK. Y. pestis, which causes plague, is a category A select agent according to the Centers for Disease Control and Prevention (CDC). Therefore, these structural and biochemical data are valuable for the design of novel medical countermeasures against plague.

  8. Suppression of Adipogenesis by 5-Hydroxy-3,6,7,8,3',4'-Hexamethoxyflavone from Orange Peel in 3T3-L1 Cells.

    PubMed

    Wang, Yu; Lee, Pei-Sheng; Chen, Yi-Fen; Ho, Chi-Tang; Pan, Min-Hsiung

    2016-09-01

    We reported previously that hydroxylated polymethoxyflavones (HPMFs) effectively suppressed obesity in high-fat-induced mouse. In this study, we further investigated the molecular mechanism of action of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF), one of major HPMFs in orange peel. Treatment of 5-OH-HxMF effectively inhibited lipid accumulation by 55-60% in a dose-dependent manner. The 5-OH-HxMF attenuated adipogenesis through downregulating adipogenesis-related transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding proteins (C/EBPs), as well as downstream target fatty acid synthase and acetyl-CoA carboxylase (ACC). 5-OH-HxMF activated adenosine monophosphate-activated protein kinase signaling and silent mating type information regulation 1 (SIRTUIN 1 or SIRT1) in 3T3-L1 adipocytes to decrease lipid accumulation. In addition, the inhibition rate of lipid accumulation was compared between 5-OH-HxMF and 3,5,6,7,8,3',4'-heptamethoxyflavone (HpMF). 5-OH-HxMF inhibited lipid accumulation 15-20% more than HpMF did, indicating that hydroxyl group at position 5 can be a key factor in the suppression of adipogenesis. PMID:27542074

  9. New 7-arylpiperazinylalkyl-8-morpholin-4-yl-purine-2,6-dione derivatives with anxiolytic activity - Synthesis, crystal structure and structure-activity study

    NASA Astrophysics Data System (ADS)

    Chłoń-Rzepa, Grażyna; Żmudzki, Paweł; Pawłowski, Maciej; Wesołowska, Anna; Satała, Grzegorz; Bojarski, Andrzej J.; Jabłoński, Mateusz; Kalinowska-Tłuścik, Justyna

    2014-06-01

    On the basis of our earlier studies with serotonin (5-HT) receptor ligands in the group of long-chain arylpiperazines (LCAPs), a new series of 7-arylpiperazinylalkyl-8-morpholin-4-yl-purine-2,6-dione derivatives (5-12) has been designed, synthesised and studied in vitro for their affinity for 5-HT1A, 5-HT2A, 5-HT6 and 5-HT7 receptors. The introduction of o-OCH3 and m-Cl into the phenylpiperazinyl moiety as well as the elongation of the linker between purine-2,6-dione core and arylpiperazine fragment modified the affinity for the tested 5-HT receptors. The structures of compounds 9-11 (hydrochloride salts) were confirmed by an X-ray diffraction method. All molecules adopted a different conformation in the crystal. The strongest observed type of interaction is a charge assisted hydrogen bond N+-H⋯Cl-. Additionally, the π-π interactions between 1,3-dimethyl-3,7-dihydropurine-2,6-dione cores of the neighbouring molecules were also observed. As it is observed in the presented crystal structures, the morpholine ring (a potential donor and acceptor of the hydrogen bonds) seems to be an attractive substituent, that may support binding to the non-specific sites of 5-HT receptors. Another interesting feature is the mutual orientation of rings in the arylpiperazine fragment, with plausible influence on ligand-receptor recognition. For compound 10, with strong 5-HT1A binding affinity, the mutual orientation of rings is determined by the intramolecular weak C-H⋯O hydrogen bond. This observation may contribute to a better understanding of the more selective binding of o-OCH3 arylpiperazine derivatives to the 5-HT1A receptor.

  10. 7 CFR 623.8 - Easement value.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... land covered by the easements. Fair market value will be based on post-flood conditions as if reclaimed... 7 Agriculture 6 2010-01-01 2010-01-01 false Easement value. 623.8 Section 623.8 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT...

  11. Draft Genome Sequences of Escherichia coli O157:H7 Strains Rafaela_II (Clade 8) and 7.1_Anguil (Clade 6) from Cattle in Argentina.

    PubMed

    Amadio, Ariel Fernando; Amigo, Natalia; Puebla, Andrea Fabiana; Farber, Marisa Diana; Cataldi, Angel Adrián

    2015-06-11

    Escherichia coli O157:H7 is a major etiologic agent of diseases in humans that cause diarrhea, hemorrhagic colitis, and hemolytic-uremic syndrome. Here, we report the draft genome sequences of two strains isolated from cattle that had high levels of Shiga toxin 2 and high lethality in mice.

  12. Draft Genome Sequences of Escherichia coli O157:H7 Strains Rafaela_II (Clade 8) and 7.1_Anguil (Clade 6) from Cattle in Argentina

    PubMed Central

    Amigo, Natalia; Puebla, Andrea Fabiana; Farber, Marisa Diana

    2015-01-01

    Escherichia coli O157:H7 is a major etiologic agent of diseases in humans that cause diarrhea, hemorrhagic colitis, and hemolytic-uremic syndrome. Here, we report the draft genome sequences of two strains isolated from cattle that had high levels of Shiga toxin 2 and high lethality in mice. PMID:26067964

  13. We are Family: the Conformations of 1-FLUOROALKANES, C_nH2n+1F (n = 2,3,4,5,6,7,8)

    NASA Astrophysics Data System (ADS)

    Obenchain, Daniel A.; Orellana, W.; Cooke, S. A.

    2016-06-01

    he pure rotational spectra of the n = 5, 6, 7, and 8 members of the 1-fluoroalkane family have been recorded between 7 GHz and 14 GHz using chirped pulse Fourier transform microwave spectroscopy. The spectra have been analyzed and results will be presented and compared with previous work on the n= 2, 3, and 4 members. The lowest energy conformer for all family members has the common feature that the fluorine is in a gauche position relative to the alkyl tail for which all other heavy atom dihedral angles, where appropriate, are 180 degrees. For the n = 3 and higher family members the second lowest energy conformer has all heavy atom dihedral angles equal to 180 degrees. For each family member transitions carried by both low energy conformers were observed in the collected rotational spectra. Quantum chemical calculations were performed and trends in the energy separations between these two common conformers will be presented as a function of chain length. Furthermore, longer chain lengths have been examined using only quantum chemical calculations and results will be presented. M. Hayashi, M. Fujitake, T. Inagusa, S. Miyazaki, J.Mol.Struct., 216, 9-26, 1990 W. Caminati, A. C. Fantoni, F. Manescalchi, F. Scappini, Mol.Phys., 64, 1089 ,1988 L. B. Favero, A. Maris, A. Degli Esposti, P. G. Favero, W. Caminati, G. Pawelke, Chem.Eur.J., 6(16), 3018-3025, 2000

  14. 8. View Southeast, showing front elevation of Brewery (Buildings 6 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. View Southeast, showing front elevation of Brewery (Buildings 6 and 7 are not visible - behind Brewery) - Weissner Brewery, Building Nos. 6 & 7, 1700 North Gay Street, Baltimore, Independent City, MD

  15. Solid-phase synthesis of 2-substituted 4-amino-7-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidines.

    PubMed

    Falcó, José L; Borrell, José I; Teixidó, Jordi

    2003-01-01

    An efficient solid-phase synthesis of 2-substituted 4-aminopyrido[2,3-d]pyrimidines 15 is reported. The procedure started by solid supporting a p-hydroxybenzaldehyde 8 to the Wang resin by using the Mitsunobu protocol. The resulting aldehyde 17 was treated with a substituted acid methyl malonate 10 to afford the corresponding alpha, beta-unsaturated ester 18, which was converted to the Michael adduct 21 by reaction with malononitrile. Cyclization of 21 with an amidine system 13 yielded the solid supported pyridopyrimidine 22, which afforded the corresponding 2-substituted 4-aminopyrido[2,3-d]pyrimidine 15 upon treatment with TFA:DCM. Compounds 15 present three diversity centers R1, R2 and R3. Having validated the chemistry on solid support, a 32-membered combinatorial library was obtained using this protocol.

  16. Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS No. 1746-01-6) in Swiss-Webster Mice (Dermal Study).

    PubMed

    1982-02-01

    the male mice (3/42, 7%; 6/28, 21%). In the DMBA-TCDD experiment, failure to have included groups skin painted with only DMBA precluded interpretation of these results. Under the conditions of this bioassay, 2,3,7,8-tetrachlorodibenzo-p-dioxin applied to the skin was not carcinogenic for male Swiss-Webster mice (the increase of fibrosarcomas in the integumentary system may have been associated with the skin application of TCDD). TCDD was carcinogenic for female Swiss-Webster mice causing fibrosarcomas in the integumentary system. Levels of Evidence of Carcinogenicity: Male Mice: Equivocal Female Mice: Positive Synonyms: 2,3,7,8-TCDD; TCDD PMID:12778178

  17. Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS No. 1746-01-6) in Swiss-Webster Mice (Dermal Study).

    PubMed

    1982-02-01

    the male mice (3/42, 7%; 6/28, 21%). In the DMBA-TCDD experiment, failure to have included groups skin painted with only DMBA precluded interpretation of these results. Under the conditions of this bioassay, 2,3,7,8-tetrachlorodibenzo-p-dioxin applied to the skin was not carcinogenic for male Swiss-Webster mice (the increase of fibrosarcomas in the integumentary system may have been associated with the skin application of TCDD). TCDD was carcinogenic for female Swiss-Webster mice causing fibrosarcomas in the integumentary system. Levels of Evidence of Carcinogenicity: Male Mice: Equivocal Female Mice: Positive Synonyms: 2,3,7,8-TCDD; TCDD

  18. SUPERSTARS III: 6-8.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Education, Raleigh.

    SUPERSTARS III is a K-8 program designed as an enrichment opportunity for self-directed learners in mathematics. The basic purpose of SUPERSTARS III is to provide the extra challenge that self-motivated students need in mathematics and to do so in a structured, long-term program that does not impinge on the normal classroom routine or the…

  19. Quantum chemical, ballistic and explosivity calculations on 2,4,6,8-tetranitro-1,3,5,7-tetraaza cyclooctatetraene: a new high energy molecule.

    PubMed

    Gejji, S P; Talawar, M B; Mukundan, T; Kurian, E M

    2006-06-30

    Ab initio molecular orbital calculations have been carried out on 2,4,6,8-tetranitro-1,3,5,7-tetraazacyclooctatetraene, the tetramer of the series (NO(2)CN)(n) where n=1-4, using the Hartree-Fock theory with the 6-31 G(d) basis set. These calculations yield three conformers for the tetramer with D(4h), C(4h) and C(2) symmetries. The nonplanar conformer with the C(2) symmetry turns out to be 99.0 and 164.4kJmol(-1), respectively, lower in energy than the C(4h) and D(4h) conformers. The electron density topography - the density at the bond critical point - has been used as a measure of the CNO(2) strengths. Based on these bond strengths, heats of formation [obtained from the parametric model 3 (PM3) method] and specific decomposition energies, it may be concluded that (NO(2)CN)(4) is a promising candidate in the class of high energy molecules. Theoretically computed explosive (velocity of detonation, detonation pressure, etc.) and ballistic (characteristic velocity, specific impulse, etc.) parameters support these conclusions.

  20. Overview and new insights into the thiol reactivity of coordinated NO in {MNO}(6/7/8) (M = Fe, Co) complexes.

    PubMed

    Rhine, Melody A; Sanders, Brian C; Patra, Ashis K; Harrop, Todd C

    2015-10-01

    The reactivity of free NO (NO(+), NO(•), and NO(-)) with thiols (RSH) is relatively well understood, and the oxidation state of the NO moiety generally determines the outcome of the reaction. However, NO/RSH interactions are often mediated at metal centers, and the fate of these species when bound to a first-row transition metal (e.g., Fe, Co) deserves further investigation. Some metal-bound NO moieties (particularly NO(+), yielding S-nitrosothiols) have been more thoroughly studied, yet the fate of these species remains highly condition-dependent and, for M-NO(-), an unexplored field. Herein, we present an overview of thiol reactions with metal nitrosyls that result in N-O bond activation, ligand substitution on {MNO} fragments, and/or redox chemistry. We also present our results pertaining to the thiol reactivity of nonheme {FeNO}(7/8) complexes [Fe(LN4(pr))(NO)](-/0) (1 and 2) and the noncorrin {CoNO}(8) complex [Co(LN4(pr))(NO)] (3), an isoelectronic analogue of the {FeNO}(8) complex 1. Among other products, the reaction of 1 with p-ClPhSH affords [Fe2(μ-SPh-p-Cl)2(NO)4](-) (anion of 6), a reduced Roussin's red ester (rRRE), which was characterized by Fourier transform infrared (FTIR), UV-vis, electron paramagnetic resonance (EPR), and X-ray diffraction. Similarly, the reaction of 1 with glutathione in buffer affords the corresponding rRRE, which has also been spectroscopically characterized by EPR and UV-vis. The oxidation states of the metals and nitrosyls both contribute to the complex nature of these interactions, and as such, we discuss the varying product distribution accordingly. These studies shed insight into the products that may form through MNO/RSH interactions that lead to NOx activation and {MNO} redox.

  1. Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice congenic at the Ah Locus.

    PubMed

    Birnbaum, L S; McDonald, M M; Blair, P C; Clark, A M; Harris, M W

    1990-07-01

    The acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in male C57BL/6J mice differing only at the Ah locus. Wild type mice (Ahb/b, "b/b") were treated once with 0, 50, 100, 200, 300, and 400 micrograms TCDD/kg po while congenic mice (Ahd/d, "d/d") received a single dose of 0, 400, 800, 1600, 2400, and 3200 micrograms TCDD/kg. Mice were checked daily, weighed twice a week, and those that survived, killed 35 days post-treatment. The LD50 values were 159 and 3351 micrograms/kg for b/b and d/d mice, respectively. Mean time to death was 22 days and was independent of dose and genotype. Decrease in body weight gain was noted in both strains 5 days after treatment and occurred at doses greater than or equal to 100 micrograms/kg in b/b mice and 1600 micrograms/kg in d/d mice. Dose-related increases in liver weight (both absolute and relative to body weight) and decreases in thymus, spleen, testes, and epididymal fat pad weights were observed at 8-24-fold higher doses in d/d than in b/b mice. A dose-related increase in segmented neutrophils was observed in both strains. Serum chemistry values indicated that 8-24X greater doses of TCDD were needed to elevate sorbitol dehydrogenase, alanine aminotransferase, and 5'-nucleotidase and to decrease total and esterified cholesterol in d/d than in b/b mice. Few effects were seen on total bile acids, serum triglycerides, glucose, or nonesterified cholesterol. In the liver, hepatocellular cytomegaly, fatty change, and bile duct hyperplasia occurred in both strains in a dose-related manner, as did thymic and splenic atrophy. Necrosis of germinal epithelium in the testes and edema in the stomach submucosa occurred at acutely toxic doses. These lesions also occurred at doses 8-24X greater in d/d than in b/b mice. Thus, the spectrum of toxicity is independent of the allele at the Ah locus, but the relative dose needed to bring about various acute responses is approximately 8-24X greater in congenic mice homozygous

  2. 7 CFR 371.8 - International Services.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Organization of the United Nations, with regard to APHIS activities in foreign countries. (5) Developing and... their effect on the agriculture industry. (6) Developing and directing programs to enhance the trade in... 7 Agriculture 5 2014-01-01 2014-01-01 false International Services. 371.8 Section...

  3. 7 CFR 371.8 - International Services.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Organization of the United Nations, with regard to APHIS activities in foreign countries. (5) Developing and... their effect on the agriculture industry. (6) Developing and directing programs to enhance the trade in... 7 Agriculture 5 2013-01-01 2013-01-01 false International Services. 371.8 Section...

  4. 7 CFR 371.8 - International Services.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Organization of the United Nations, with regard to APHIS activities in foreign countries. (5) Developing and... their effect on the agriculture industry. (6) Developing and directing programs to enhance the trade in... 7 Agriculture 5 2012-01-01 2012-01-01 false International Services. 371.8 Section...

  5. 24 CFR 8.6 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Communications. 8.6 Section 8.6... URBAN DEVELOPMENT General Provisions § 8.6 Communications. (a) The recipient shall take appropriate steps to ensure effective communication with applicants, beneficiaries, and members of the public....

  6. 24 CFR 8.6 - Communications.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Communications. 8.6 Section 8.6... URBAN DEVELOPMENT General Provisions § 8.6 Communications. (a) The recipient shall take appropriate steps to ensure effective communication with applicants, beneficiaries, and members of the public....

  7. 24 CFR 8.6 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Communications. 8.6 Section 8.6... URBAN DEVELOPMENT General Provisions § 8.6 Communications. (a) The recipient shall take appropriate steps to ensure effective communication with applicants, beneficiaries, and members of the public....

  8. 24 CFR 8.6 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Communications. 8.6 Section 8.6... URBAN DEVELOPMENT General Provisions § 8.6 Communications. (a) The recipient shall take appropriate steps to ensure effective communication with applicants, beneficiaries, and members of the public....

  9. 24 CFR 8.6 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Communications. 8.6 Section 8.6... URBAN DEVELOPMENT General Provisions § 8.6 Communications. (a) The recipient shall take appropriate steps to ensure effective communication with applicants, beneficiaries, and members of the public....

  10. The 3 May 2006 (Mw 8.0) and 19 March 2009 (Mw 7.6) Tonga earthquakes: Intraslab compressional faulting below the megathrust

    NASA Astrophysics Data System (ADS)

    Meng, Qingjun; Heeszel, David S.; Ye, Lingling; Lay, Thorne; Wiens, Douglas A.; Jia, Minghai; Cummins, Phil R.

    2015-09-01

    The Tonga subduction zone is among the most seismically active regions and has the highest plate convergence rate in the world. However, recorded thrust events confidently located on the plate boundary have not exceeded Mw 8.0, and the historic record suggests low seismic coupling along the arc. We analyze two major thrust fault earthquakes that occurred in central Tonga in 2006 and 2009. The 3 May 2006 Mw 8.0 event has a focal mechanism consistent with interplate thrusting, was located west of the trench, and caused a moderate regional tsunami. However, long-period seismic wave inversions and finite-fault modeling by joint inversion of teleseismic body waves and local GPS static offsets indicate a slip distribution centered ~65 km deep, about 30 km deeper than the plate boundary revealed by locations of aftershocks, demonstrating that this was an intraslab event. The aftershock locations were obtained using data from seven temporary seismic stations deployed shortly after the main shock, and most lie on the plate boundary, not on either nodal plane of the deeper main shock. The fault plane is ambiguous, and investigation of compound rupture involving coseismic slip along the megathrust does not provide a better fit, although activation of megathrust faulting is responsible for the aftershocks. The 19 March 2009 Mw 7.6 compressional faulting event occurred below the trench; finite-fault and W-phase inversions indicate an intraslab, ~50 km deep centroid, with ambiguous fault plane. This event also triggered small megathrust faulting. There continues to be a paucity of large megathrust earthquakes in Tonga.

  11. Formation of a Vitamin C Conjugate of Acrolein and its Paraoxonase-mediated Conversion into 5,6,7,8-Tetrahydroxy-4-oxooctanal

    PubMed Central

    Kesinger, Nicholas G.; Langsdorf, Brandi L.; Yokochi, Alexandre F.; Miranda, Cristobal L.; Stevens, Jan F.

    2010-01-01

    Vitamin C (ascorbic acid) has been reported to participate in Michael addition reactions in vitro to form vitamin C conjugates with α,β-unsaturated aldehydes, such as acrolein. This study shows evidence for the formation and metabolism of the vitamin C conjugate of acrolein (AscACR) in cultured human monocytic THP-1 cells exposed to acrolein diacetate. By using 18O and 13C labeling in combination with liquid chromatography–tandem mass spectrometry, AscACR was shown to undergo hydrolytic conversion of the ascorbyl lactone into an intermediate carboxylic acid. Subsequent decarboxylation of the carboxylic acid yielded 5,6,7,8-tetrahydroxy-4-oxooctanal (THO). When THP-1 cells were pretreated with ascorbic acid (1 mM, 18 hours) and then exposed to acrolein diacetate, THO was detected as its pentafluorobenzyl oxime derivative in the cell lysates and medium. Treatment of THP-1 cells with both ascorbic acid and acrolein diacetate was required for THO formation. The formation of THO from AscACR was facilitated by the lactonase enzymes, human recombinant paraoxonases 1 and 2. THP-1 cells exhibited PON activity which explains the catalytic conversion of AscACR into THO in these cells. THO was formed in addition to metabolites of the glutathione conjugate of acrolein, indicating that THO formation contributes to the elimination of acrolein in a cellular environment. PMID:20353174

  12. Double aromaticity in transition metal centered double-ring boron clusters M@B2n (M = Ti, Cr, Fe, Ni, Zn; n = 6, 7, 8).

    PubMed

    Xu, Chang; Cheng, Longjiu; Yang, Jinlong

    2014-09-28

    It is well known that double-ring boron clusters have got the special double aromaticity with delocalized π orbitals in two directions (tangential and radial), which are potential ligands centered by a transition metal. In this article, the transition metal centered double-ring boron clusters M@B2n (M = Ti, Cr, Fe, Ni, Zn; n = 6, 7, 8) are theoretically investigated by density functional theory calculations. These endohedral compounds have also got double aromaticity in both tangential and radial directions. Interestingly, the tangential delocalized π orbitals of boron ligands following the Huckle's (4n + 2) rule do not interact with the central metal, while the radial π orbitals of boron ligands are bonded with the central mental to form spd-π endohedral bonding. The spd-π endohedral bonding follows the 18e-principle in Ni@B14 and Fe@B16. However, due to the flat shape of the compounds, 14e (Cr@B14) and 16e (Ni@B12) can also be electronically very stable where the energy levels of the spd-π orbitals delocalized in z-direction rise up. This intriguing bonding model makes sense in further study of the boron chemistry.

  13. Characterization of the Neurospora crassa Cell Fusion Proteins, HAM-6, HAM-7, HAM-8, HAM-9, HAM-10, AMPH-1 and WHI-2

    PubMed Central

    Fu, Ci; Ao, Jie; Dettmann, Anne; Seiler, Stephan; Free, Stephen J.

    2014-01-01

    Intercellular communication of vegetative cells and their subsequent cell fusion is vital for different aspects of growth, fitness, and differentiation of filamentous fungi. Cell fusion between germinating spores is important for early colony establishment, while hyphal fusion in the mature colony facilitates the movement of resources and organelles throughout an established colony. Approximately 50 proteins have been shown to be important for somatic cell-cell communication and fusion in the model filamentous fungus Neurospora crassa. Genetic, biochemical, and microscopic techniques were used to characterize the functions of seven previously poorly characterized cell fusion proteins. HAM-6, HAM-7 and HAM-8 share functional characteristics and are proposed to function in the same signaling network. Our data suggest that these proteins may form a sensor complex at the cell wall/plasma membrane for the MAK-1 cell wall integrity mitogen-activated protein kinase (MAPK) pathway. We also demonstrate that HAM-9, HAM-10, AMPH-1 and WHI-2 have more general functions and are required for normal growth and development. The activation status of the MAK-1 and MAK-2 MAPK pathways are altered in mutants lacking these proteins. We propose that these proteins may function to coordinate the activities of the two MAPK modules with other signaling pathways during cell fusion. PMID:25279949

  14. The Surface Displacement Field of the November 8, 1997, Mw7.6 Manyi (Tibet) Earthquake Observed with ERS InSAR Data

    NASA Technical Reports Server (NTRS)

    Peltzer, G.; Crampe, F.

    1998-01-01

    ERS2 radar data acquired before and after the Mw7.6, Manyi (Tibet) earthquake of November 8, 1997, provide geodetic information about the surface displacement produced by the earthquake in two ways. (1) The sub-pixel geometric adjustment of the before and after images provides a two dimensional offset field with a resolution of approx, 1m in both the range (radar line of sight) and azimuth (satellite track) directions. Comparison of offsets in azimuth and range indicates that the displacement along the fault is essentially strike-slip and in a left-lateral sense. The offset map reveals a relatively smooth and straight, N78E surface rupture that exceeds 150 km in length, consistent with the EW plane of the Harvard CMT solution. The rupture follows the trace of a quaternary fault visible on satellite imagery (Tapponnier and Molnar, 1978; Wan Der Woerd, pers. comm.). (2) Interferometric processing of the SAR data provides a range displacement map with a precision of a few millimeters. The slip distribution along the rupture reconstructed from the range change map is a bell-shaped curve in the 100-km long central section of the fault with smaller, local maxima near both ends. The curve shows that the fault slip exceeds 2.2 m in range, or 6.2 in strike-slip, along a 30-km long section of the fault and remains above 1 m in range, approx. 3 m strike-slip, along most of its length. Preliminary forward modeling of the central section of the rupture, assuming a uniform slip distribution with depth, indicates that the slip occur-red essentially between 0 and the depth of 10 km, consistent with a relatively shallow event (Velasco et al., 1998).

  15. Comparison of Values in 5th, 6th, 7th and 8th Grade Primary Education Music Class Students'? Workbooks According to Rokeach?s and Akbas's Value Classifications

    ERIC Educational Resources Information Center

    Çakirer, H. Serdar

    2014-01-01

    The aim of the present study is to compare the values in the songs of 5th, 6th, 7th and 8th grade primary education music classes students? workbooks according to the value categorizations proposed by Rockeach and Akbas and which values among the categories mentioned are taught to the students in the 5th, 6th, 7th and 8th grade primary education…

  16. Rupture Process of the Tonga Earthquakes of 3 May 2006 (Mw 8.0) and 19 March 2009 (Mw 7.6): Intraslab Thrust Deformation Below the Megathrust

    NASA Astrophysics Data System (ADS)

    Meng, Q.; Ye, L.; Lay, T.; Cummins, P. R.

    2014-12-01

    The Tonga subduction zone is one of the most seismically active areas in the world, with a high rate of plate convergence between the subducting Pacific plate and the Tonga arc from 15°S to 25°S.However, seismically recorded large interplate thrusting events along the arc have not been larger than about Mw 8.0, and the degree of interplate seismic coupling has been inferred to vary from moderate to very low going from northern Tonga to southern Tonga [e.g., Scholz and Campos, 2012]. The possibility of this region experiencing a low probability maximum magnitude event of Mw8.57 up to 9.14 has been raised, but a paucity of geodetic observations and their distance from the Tonga trench have precluded assessments of slip deficit accumulation on the megathrust [Wallace et al., 2005]. Faulting mechanisms of historical large shallow earthquakes are uncertain [e.g., Okal et al., 2011], and some recent large events have been normal faulting or thrust-faulting intraslab events, so catalog-based assessments of seismic coupling are uncertain. Two recent large thrust-faulting earthquakes in 2006 and 2009 further complicate such assessments. The 3 May 2006 Mw8.0 event was located 100km west of the trench and caused a substantial regional tsunami, so it is sometimes assumed to be an interplate rupture. However, finite-fault modeling of teleseismic body waves supports a slip distribution centered about 60 km depth, consistent with centroid depths from W-phase (60.5 km) and global CMT (65 km) inversions. This was an intraslab thrust event with estimated stress drop of ~10 MPa. The fault plane is difficult to resolve unambiguously using teleseismic body waves, but joint inversion with static offsets from local GPS stations favors a shallow-dipping plane subparallel to the megathrust, or possibly a steeply dipping plane with triggered megathrust faulting. The 19 March 2009 Mw 7.6 thrust event occurred below the trench, and finite-fault and W-phase inversions indicate a 45km deep

  17. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  18. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  19. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  20. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  1. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  2. 7 CFR 930.6 - District.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false District. 930.6 Section 930.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Definitions § 930.6 District. District means one of the subdivisions of the production area described in §...

  3. 7 CFR 915.6 - Fiscal year.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Fiscal year. 915.6 Section 915.6 Agriculture... Regulating Handling Definitions § 915.6 Fiscal year. Fiscal year means the twelve-month period ending March 31 of each year....

  4. 7 CFR 987.6 - Crop year.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Crop year. 987.6 Section 987.6 Agriculture Regulations... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.6 Crop year. Crop year means the 12-month period beginning October 1 of each year and ending September 30 of the following year....

  5. 7 CFR 915.6 - Fiscal year.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Fiscal year. 915.6 Section 915.6 Agriculture... Regulating Handling Definitions § 915.6 Fiscal year. Fiscal year means the twelve-month period ending March 31 of each year....

  6. 7 CFR 987.6 - Crop year.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Crop year. 987.6 Section 987.6 Agriculture Regulations... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.6 Crop year. Crop year means the 12-month period beginning October 1 of each year and ending September 30 of the following year....

  7. 7 CFR 915.6 - Fiscal year.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Fiscal year. 915.6 Section 915.6 Agriculture... Regulating Handling Definitions § 915.6 Fiscal year. Fiscal year means the twelve-month period ending March 31 of each year....

  8. 7 CFR 915.6 - Fiscal year.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal year. 915.6 Section 915.6 Agriculture... Regulating Handling Definitions § 915.6 Fiscal year. Fiscal year means the twelve-month period ending March 31 of each year....

  9. 7 CFR 987.6 - Crop year.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Crop year. 987.6 Section 987.6 Agriculture Regulations... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.6 Crop year. Crop year means the 12-month period beginning October 1 of each year and ending September 30 of the following year....

  10. 7 CFR 915.6 - Fiscal year.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Fiscal year. 915.6 Section 915.6 Agriculture... Regulating Handling Definitions § 915.6 Fiscal year. Fiscal year means the twelve-month period ending March 31 of each year....

  11. 7 CFR 987.6 - Crop year.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Crop year. 987.6 Section 987.6 Agriculture Regulations... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.6 Crop year. Crop year means the 12-month period beginning October 1 of each year and ending September 30 of the following year....

  12. 7 CFR 987.6 - Crop year.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Crop year. 987.6 Section 987.6 Agriculture Regulations... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.6 Crop year. Crop year means the 12-month period beginning October 1 of each year and ending September 30 of the following year....

  13. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  14. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  15. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  16. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  17. 7 CFR 981.6 - Shelled almonds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Shelled almonds. 981.6 Section 981.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 981.6 Shelled almonds. Shelled almonds mean raw or roasted almonds...

  18. 7 CFR 948.6 - Seed potatoes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Seed potatoes. 948.6 Section 948.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE IRISH POTATOES GROWN IN COLORADO Order Regulating Handling Definitions § 948.6 Seed potatoes. Seed potatoes or seed means any...

  19. 7 CFR 948.6 - Seed potatoes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Seed potatoes. 948.6 Section 948.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE IRISH POTATOES GROWN IN COLORADO Order Regulating Handling Definitions § 948.6 Seed potatoes. Seed potatoes or seed means any...

  20. 7 CFR 948.6 - Seed potatoes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Seed potatoes. 948.6 Section 948.6 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE IRISH POTATOES GROWN IN COLORADO Order Regulating Handling Definitions § 948.6 Seed potatoes. Seed potatoes or seed means any...

  1. 7 CFR 948.6 - Seed potatoes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Seed potatoes. 948.6 Section 948.6 Agriculture... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE IRISH POTATOES GROWN IN COLORADO Order Regulating Handling Definitions § 948.6 Seed potatoes. Seed potatoes or seed means any...

  2. 7 CFR 948.6 - Seed potatoes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Seed potatoes. 948.6 Section 948.6 Agriculture... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE IRISH POTATOES GROWN IN COLORADO Order Regulating Handling Definitions § 948.6 Seed potatoes. Seed potatoes or seed means any...

  3. 7 CFR 8.8 - Use by public informational services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Use by public informational services. 8.8 Section 8.8 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.8 Use by public informational services. (a) In any advertisement, display, exhibit, visual and audio-visual material, news...

  4. 7 CFR 8.8 - Use by public informational services.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Use by public informational services. 8.8 Section 8.8 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.8 Use by public informational services. (a) In any advertisement, display, exhibit, visual and audio-visual material, news...

  5. Temporal evolution of surface rupture deduced from coseismic multi-mode secondary fractures: Insights from the October 8, 2005 (Mw 7.6) Kashmir earthquake, NW Himalaya

    NASA Astrophysics Data System (ADS)

    Sayab, Mohammad; Khan, Muhammad Asif

    2010-10-01

    Detailed rupture-fracture analyses of some of the well-studied earthquakes have revealed that the geometrical arrangement of secondary faults and fractures can be used as a geological tool to understand the temporal evolution of slip produced during the mainshock. The October 8, 2005 Mw 7.6 Kashmir earthquake, NW Himalaya, surface rupture provides an opportunity to study a complex network of secondary fractures developed on the hanging wall of the fault scarp. The main fault scarp is clearly thrust-type, rupture length is ~ 75 ± 5 km and the overall trend of the rupture is NW-SE. We present the results of our detailed structural mapping of secondary faults and fractures at 1:100 scale, on the hanging wall of the southern end of the rupture in the vicinity of the Sar Pain. Secondary ruptures can be broadly classified as two main types, 1) normal faults and, (2) right-lateral strike-slip 'Riedel' fractures. The secondary normal faults are NW-SE striking, with a maximum 3.3 meter vertical displacement and 2.5 meter horizontal displacement. Estimated total horizontal extension across the secondary normal faults is 3.1-3.5%. We propose that the bending-moment and coseismic stress relaxation can explain the formation of secondary normal faults on the hanging wall of the thrust fault. The strike-slip 'Riedel' fractures form distinct sets of tension (T) and shear fractures (R', R, Y) with right-lateral displacement. Field observations revealed that the 'Riedel' fractures (T) cut the secondary normal faults. In addition, there is kinematic incompatibility and magnitude mismatch between the secondary normal faults and strike-slip 'Riedel' fractures. The cross-cutting relationship, geometric and magnitude incoherence implies a temporal evolution of slip from dip- to strike-slip during the mainshock faulting. The interpretation is consistent with the thrust fault plane solution with minor right-lateral strike-slip component.

  6. Modelling macroseismic observations for historical earthquakes: the cases of the M = 7.0, 1954 Sofades and M = 6.8, 1957 Velestino events (central Greece)

    NASA Astrophysics Data System (ADS)

    Papazachos, Giannis; Papazachos, Costas; Skarlatoudis, Andreas; Kkallas, Harris; Lekkas, Efthimios

    2016-01-01

    We attempt to model the spatial distribution of the strong ground motion for the large M = 7.0, 1954 Sofades and M = 6.8, 1957 Velestino events (southern Thessaly basin, central Greece), using the macroseismic intensities ( I M M up to 9+) observed within the broader Thessaly area. For this reason, we employ a modified stochastic method realised by the EXSIM algorithm for extended sources, in order to reproduce the damage distribution of these earthquakes, in an attempt to combine existing earthquake information and appropriate scaling relations with surface geology and to investigate the efficiency of the available macroseismic data. For site-effects assessment, we use a new digital geological map of the broader Thessaly basin, where geological formations are grouped by age and mapped on appropriate NEHRP soil classes. Using the previous approach, we estimate synthetic time series for different rupture scenarios and employ various calibrating relations between PGA/PGV and macroseismic intensity, allowing the generation of synthetic (stochastic) isoseismals. Also, different site amplification factors proposed for the broader Aegean area, according to local geology, are tested. Finally, we also perform a sensitivity analysis of the fault location, taking into account the available neotectonic data for the broader southern Thessaly fault zone. The finally determined fault locations are different than previously proposed, in agreement with the available neotectonic information. The observed macroseismic intensities are in good agreement with the ones derived from the synthetic waveforms, verifying both the usefulness of the approach, as well as of the macroseismic data used. Finally, site-effects show clear correlation with the geological classification employed, with constant amplification factors for each soil class generally providing better results than generic transfer functions.

  7. Adsorption and fractionation of a muck fulvic acid on kaolinite and goethite at pH 3.7,6, and 8

    USGS Publications Warehouse

    Namjesnik-Dejanovic, K.; Maurice, P.A.; Aiken, G.R.; Cabaniss, S.; Chin, Y.-P.; Pullin, M.J.

    2000-01-01

    Molecular weight (MW) of humic materials is a key factor controlling proton and metal binding and organic pollutant partitioning. Several studies have suggested preferential adsorption of higher MW, more aromatic moieties to mineral surfaces; quantification of such processes is fundamental to development of predictive models. We used high pressure size exclusion chromatography (HPSEC) to quantify MW changes upon adsorption of a muck fulvic acid (MFA) extracted from a peat deposit to kaolinite and goethite, at pH 3.7,6, and 8 at 22 ??C, I = 0.01 (NaC1), 24-h reaction time. MFA adsorption affinity was greater for goethite than for kaolinite. At concentrations less than the adsorption maximum (A(max)) for both adsorbents, the weight-average MW (M(w)) of MFA remaining in solution decreased by as much as several hundred Daltons relative to control samples, indicating preferential adsorption of the higher MW components. At concentrations more than A(max), M(w) of MFA in solution did not change appreciably. Although total adsorption decreased significantly as pH increased, fractionation as measured by change in M(w) remained similar, perhaps indicating greater selectivity for higher MW components at higher pH. Absorptivities at ?? = 280 nm normalized to mg C L-1 (??) suggested preferential adsorption of more aromatic moieties to kaolinite. ?? could not be used for goethite-reacted samples because high Fe concentrations in the aqueous phase brought about by goethite dissolution interfered with the spectroscopic analysis. Preliminary kinetic experiments suggested that smaller molecules adsorbed first and were replaced by larger molecules whose adsorption was thermodynamically favored.

  8. The 16 April 2016, MW 7.8 (MS 7.5) Ecuador earthquake: A quasi-repeat of the 1942 MS 7.5 earthquake and partial re-rupture of the 1906 MS 8.6 Colombia-Ecuador earthquake

    NASA Astrophysics Data System (ADS)

    Ye, Lingling; Kanamori, Hiroo; Avouac, Jean-Philippe; Li, Linyan; Cheung, Kwok Fai; Lay, Thorne

    2016-11-01

    The 2016 Ecuador MW 7.8 earthquake ruptured the subduction zone boundary between the Nazca and South American plates. Joint modeling of seismic and tsunami observations indicates an ∼120 km long rupture area beneath the coastline north of the 1998 MW 7.2 rupture. The slip distribution reveals two discrete asperities near the hypocenter and around the equator. Their locations and the patchy pattern are consistent with the prior interseismic geodetic strain, which showed highly locked patches also beneath the coastline. Aftershocks cluster along two streaks, one aligned nearly parallel to the plate convergence direction up-dip of the main slip patches, and the other on a trench-perpendicular lineation south of the 1958 rupture zone. Comparisons of seismic waveforms and magnitudes show that the 2016 event and 1942 earthquakes have similar surface wave magnitude (MS 7.5), overlapping rupture areas, and similar main pulses of moment rate. The same area ruptured as the southernmost portion of the larger earthquake of 1906 (MW 8.6, MS 8.6). The seismic behavior reflects persistent heterogeneous frictional properties of the Colombia-Ecuador megathrust.

  9. Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime.

    PubMed

    Amici, Raffaella; Bigogno, Chiara; Boggio, Roberto; Colombo, Andrea; Courtney, Stephen M; Dal Zuffo, Roberto; Dondio, Giulio; Fusar, Fulvia; Gagliardi, Stefania; Minucci, Saverio; Molteni, Marco; Montalbetti, Christian A G N; Mortoni, Annalisa; Varasi, Mario; Vultaggio, Stefania; Mercurio, Ciro

    2014-07-01

    Heat-shock protein 90 (Hsp90) is a molecular chaperone involved in the stabilization of key oncogenic signaling proteins, and therefore, inhibition of Hsp90 represents a new strategy in cancer therapy. 2-Amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime is a racemic Hsp90 inhibitor that targets the N-terminal adenosine triphosphatase site. We developed a method to resolve the enantiomers and evaluated their inhibitory activity on Hsp90 and the consequent antitumor effects. The (S) stereoisomer emerged as a potent Hsp90 inhibitor in biochemical and cellular assays. In addition, this enantiomer exhibited high oral bioavailability in mice and excellent antitumor activity in two different human cancer xenograft models.

  10. Efficient Catalyst One-Pot Synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione Derivatives Complemented by Antibacterial Activity

    PubMed Central

    Al-Majedy, Yasameen K.; Kadhum, Abdul Amir H.; Mohamad, Abu Bakar

    2016-01-01

    The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-(aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide (TBAB), diammonium hydrogen phosphate (DAHP), or ferric chloride (FeCl3), respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity. PMID:27563671

  11. Efficient Catalyst One-Pot Synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione Derivatives Complemented by Antibacterial Activity.

    PubMed

    Al-Majedy, Yasameen K; Al-Amiery, Ahmed A; Kadhum, Abdul Amir H; Mohamad, Abu Bakar

    2016-01-01

    The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-(aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide (TBAB), diammonium hydrogen phosphate (DAHP), or ferric chloride (FeCl3), respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity. PMID:27563671

  12. Crystal structure of (1S,3R,8R,9R)-2,2-di-chloro-3,7,7-tri-methyl-10-methylenetri-cyclo-[6.4.0.0(1,3)]dodecan-9-ol.

    PubMed

    Benzalim, Ahmed; Auhmani, Aziz; Bimoussa, Abdoullah; Ait Itto, My Youssef; Daran, Jean-Claude; Auhmani, Abdelwahed

    2016-08-01

    The title compound, C16H24Cl2O, was synthesized by treating (1S,3R,8S,9R,10S)-2,2-di-chloro-3,7,7,10-tetra-methyl-9,10-ep-oxy-tri-cyclo-[6.4.0.0(1,3)]dodecane with a concentrated solution of hydro-bromic acid. It is built up from three fused rings: a cyclo-heptane ring, a cyclo-hexyl ring bearing alkene and hy-droxy substituents, and a cyclo-propane ring bearing two chlorine atoms. The asymmetric unit contains two mol-ecules linked by an O-H⋯O hydrogen bond. In the crystal, further O-H⋯O hydrogen bonds build up an R 4 (4)(8) cyclic tetra-mer. One of the mol-ecules presents disorder that affects the seven-membered ring. In both mol-ecules, the six-membered rings display a chair conformation, whereas the seven-membered rings display conformations inter-mediate between boat and twist-boat for the non-disordered mol-ecule and either a chair or boat and twist-boat for the disordered mol-ecule owing to the disorder. The absolute configuration for both mol-ecules is 1S,3R,8R,9R and was deduced from the chemical pathway and further confirmed by the X-ray structural analysis. PMID:27536404

  13. Synthesis and antiviral evalution of some novel pyrazoles and pyrazolo[3,4-d]pyridazines bearing 5,6,7,8-tetrahydronaphthalene.

    PubMed

    Hamdy, Nehal A; El-Senousy, Waled M

    2013-01-01

    The enaminone 2 was reacted with hydrazonyl halides 3a-d to afford the corresponding pyrazole derivatives (6a-d) which reacted with hydrazine hydrate to afford the new pyrazolo[3,4-d]pyridazine derivatives 7a-d, respectively. In addition, compound 2 was reacted with some primary aromatic amines to afford the corresponding secondary enaminones 10a-c and reacted with sulfapyridine or sulfapyrimidine to afford the corresponding sulfonamide derivatives 12a and 12b. Evaluation of these new compounds against rotavirus Wa strain and adenovirus type 7 showed promising antiviral activity.

  14. Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions.

    PubMed

    Kemnitzer, William; Kasibhatla, Shailaja; Jiang, Songchun; Zhang, Hong; Zhao, Jianghong; Jia, Shaojuan; Xu, Lifen; Crogan-Grundy, Candace; Denis, Réal; Barriault, Nancy; Vaillancourt, Louis; Charron, Sylvie; Dodd, Jennifer; Attardo, Giorgio; Labrecque, Denis; Lamothe, Serge; Gourdeau, Henriette; Tseng, Ben; Drewe, John; Cai, Sui Xiong

    2005-11-01

    As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the SAR of 4-aryl-4H-chromenes with modifications at the 7- and 5-, 6-, 8-positions. It was found that a small hydrophobic group, such as NMe2, NH2, NHEt, and OMe, is preferred at the 7-position. Di-substitution at either the 5,7-positions or the 6,7-positions generally led to a large decrease in potency. Di-substitution at the 7,8-positions, in general, was found to result in potent compounds. 7-NMe2, 7-NHEt, 7-OMe, and 7,8-di-NH2 analogs were found to have similar SAR for the 4-aryl group, and several 7-substituted and 7,8-di-substituted analogs were found to have similar potencies as the lead compound MX58151 (2a) both as caspase activators and inhibitors of cell proliferation.

  15. Along-Arc and Back-Arc Attenuation, Site Response, and Source Spectrum for the Intermediate-Depth 8 January 2006 M 6.7 Kythera, Greece, Earthquake

    USGS Publications Warehouse

    Boore, D.M.; Skarlatoudis, A.A.; Margaris, B.N.; Costas, B.P.; Ventouzi, C.

    2009-01-01

    An M 6.7 intermediate-depth (66 km), in-slab earthquake occurring near the island of Kythera in Greece on 8 January 2006 was well recorded on networks of stations equipped with acceleration sensors and with broadband velocity sensors. All data were recorded digitally using recording instruments with resolutions ranging from almost 11 to 24 bits. We use data from these networks to study the distance dependence of the horizontal-component Fourier acceleration spectra (FAS) and horizontal-component pseudoabsolute response spectral acceleration (PSA). For purposes of simulating motions in the future, we parameterize the distance decay using several forms of the geometrical-spreading function, for each of which we derive Q as a function of frequency. By extrapolating the distance decay back to 1 km, we obtain a reference spectrum that can be used in future simulations. This spectrum requires a more complicated spectral shape than the classic single-corner-frequency model; in particular, there appears to be an enhancement of motion around 0.2-0.3 Hz that may be due to the radiation of a 3-5 sec pulse from the source. We infer a ??0 value of about 0.055 sec for rock stations and a stress parameter in the range of 400-600 bars. We also find distinctive differences in the site response of stations on soft soil and soil; both the FAS and the 5% damped PSA amplifications have similar peak amplitudes (about 2 and 4 for soil and soft-soil sites, respectively, relative to the rock sites) at similar frequencies (between about 0.4 and 2.0 Hz, with the soft-soil amplifications peaking at somewhat lower frequencies than the soil amplifications). One of the most distinctive features of the data is the clear difference in the motions for along-arc and back-arc stations, with the former being significantly higher than the latter over a broad range of frequencies at distances beyond about 250 km. The motions from the Kythera earthquake are roughly comparable to those from intermediate

  16. Oxidative stress in female B6C3F1 mice following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

    PubMed

    Slezak, B P; Hatch, G E; DeVito, M J; Diliberto, J J; Slade, R; Crissman, K; Hassoun, E; Birnbaum, L S

    2000-04-01

    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly persistent trace environmental contaminant and is one of the most potent toxicants known to man. Hassoun et al. (1998, Toxicol. Sci. 42, 23-27) reported an increase in the production of reactive oxygen species (ROS) in the brain of female B6C3F1 mice following subchronic exposure to TCDD at doses as low as 0.45 ng/kg/day. In the present study, oxidative stress was characterized in liver, spleen, lung, and kidney following subchronic (0.15-150 ng/kg; 5 days/week for 13 weeks, po) or acute exposure (0.001-100 microg/kg, po) to TCDD in order to investigate the interaction between tissue concentration and time for production of ROS. Seven days following acute administration of TCDD, mice were sacrificed; they demonstrated increases in liver superoxide anion production (SOAP) and thiobarbituric acid reactive substances (TBARS) at doses of 10 and 100 microg/kg, associated with hepatic TCDD concentrations of 55 and 321 ng/g, respectively. Liver obtained from mice following subchronic TCDD exposure demonstrated an increase in SOAP and TBARS above controls at doses of 150 ng/kg/day with liver TCDD concentration of only 12 ng/g. Interestingly, glutathione (GSH) levels in lung and kidney following sub-chronic TCDD exposure were decreased at the low dose of 0.15 ng/kg/day. This effect disappeared at higher TCDD doses. The data suggest that higher tissue TCDD concentrations are required to elicit oxidative stress following acute dosing than with subchronic TCDD exposure. Therefore, the mechanism of ROS production following TCDD exposure does not appear to be solely dependent upon the concentration of TCDD within the tissue. In addition, very low doses of TCDD that result in tissue concentrations similar to the background levels found in the human population produced an effect on an oxidative stress endogenous defense system. The role of this effect in TCDD-mediated toxicity is not known and warrants further investigation.

  17. [Arg6,D-Trp7,9,NmePhe8]-substance P (6–11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism

    PubMed Central

    MacKinnon, A C; Armstrong, R A; Waters, C M; Cummings, J; Smyth, J F; Haslett, C; Sethi, T

    1999-01-01

    [Arg6,D-Trp7,9,NmePhe8]-substance P (6–11) (antagonist G) is a novel class of anti-cancer agent that inhibits small-cell lung cancer (SCLC) cell growth in vitro and in vivo and is entering phase II clinical investigation for the treatment of SCLC. Although antagonist G blocks SCLC cell growth (IC50 = 24.5 ± 1.5 and 38.5 ± 1.5 μM for the H69 and H510 cell lines respectively), its exact mechanism of action is unclear. This study shows that antagonist G stimulates apoptosis as assessed by morphology (EC50 = 5.9 ± 0.1 and 15.2 ± 2.7 μM for the H69 and H510 cell lines respectively) and stimulates c-jun-N-terminal kinase (JNK) activity in SCLC cells (EC50 = 3.2 ± 0.1 and 15.2 ± 2.7 μM). This activity is neuropeptide-independent, but dependent on the generation of reactive oxygen species (ROS) and is inhibited by the free radical scavenger n-acetyl cysteine. Furthermore, antagonist G itself induces inflammation (59% increase in oedema volume compared to control) and potentiates (by 35–40%) bradykinin-induced oedema formation in vivo. In view of these results we show that, as well as acting as a ‘broad-spectrum’ neuropeptide antagonist, antagonist G stimulates basal G-protein activity in SCLC cell membranes (81 ± 12% stimulation at 10 μM), thereby displaying a unique ability to stimulate certain signal transduction pathways by activating G-proteins. This novel activity may be instrumental for full anti-cancer activity in SCLC cells and may also account for antagonist G activity in non-neuropeptide-dependent cancers. © 1999 Cancer Research Campaign PMID:10362111

  18. Analysis and modelling of tsunami-induced tilt for the 2007, M = 7.6, Tocopilla and the 2010, M = 8.8 Maule earthquakes, Chile, from long-base tiltmeter and broadband seismometer records

    NASA Astrophysics Data System (ADS)

    Boudin, F.; Allgeyer, S.; Bernard, P.; Hébert, H.; Olcay, M.; Madariaga, R.; El-Madani, M.; Vilotte, J.-P.; Peyrat, S.; Nercessian, A.; Schurr, B.; Esnoult, M.-F.; Asch, G.; Nunez, I.; Kammenthaler, M.

    2013-07-01

    We present a detailed study of tsunami-induced tilt at in-land sites, to test the interest and feasibility of such analysis for tsunami detection and modelling. We studied tiltmeter and broadband seismometer records of northern Chile, detecting a clear signature of the tsunamis generated by the 2007 Tocopilla (M = 7.6) and the 2010 Maule (M = 8.8) earthquakes. We find that these records are dominated by the tilt due to the elastic loading of the oceanic floor, with a small effect of the horizontal gravitational attraction. We modelled the Maule tsunami using the seismic source model proposed by Delouis et al. and a bathymetric map, correctly fitting three tide gauge records of the area (Antofagasta, Iquique and Arica). At all the closest stations (7 STS2, 2 long-base tiltmeters), we correctly modelled the first few hours of the tilt signal for the Maule tsunami. The only phase mismatch is for the site that is closer to the ocean. We find a tilt response of 0.005-0.01 μm at 7 km away from the coastline in response to a sea level amplitude change of 10 cm. For the Maule earthquake, we observe a clear tilt signal starting 20 min before the arrival time of the tsunami at the nearest point on the coastline. This capability of tilt or seismic sensors to detect distant tsunamis before they arrive has been successfully tested with a scenario megathrust in the southern Peru-northern Chile seismic gap. However, for large events near the stations, this analysis may no longer be feasible, due to the large amplitude of the long-period seismic signals expected to obscure the loading signal. Inland tilt measurements of tsunamis smooth out short, often unmodelled wavelengths of the sea level perturbation, thus providing robust, large-scale images of the tsunami. Furthermore, tilt measurements are not expected to saturate even for the largest run-ups, nor to suffer from near-coast tsunami damages. Tiltmeters and broadband seismometers are thus valuable instruments for monitoring

  19. 6 CFR 5.8 - Business information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... requirements of Executive Order 12600 (3 CFR, 1988 Comp., p. 235); or (4) The designation made by the submitter... 6 Domestic Security 1 2010-01-01 2010-01-01 false Business information. 5.8 Section 5.8 Domestic... Freedom of Information Act § 5.8 Business information. (a) In general. Business information obtained...

  20. 6 CFR 5.8 - Business information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... requirements of Executive Order 12600 (3 CFR, 1988 Comp., p. 235); or (4) The designation made by the submitter... 6 Domestic Security 1 2013-01-01 2013-01-01 false Business information. 5.8 Section 5.8 Domestic... Freedom of Information Act § 5.8 Business information. (a) In general. Business information obtained...

  1. 6 CFR 5.8 - Business information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... requirements of Executive Order 12600 (3 CFR, 1988 Comp., p. 235); or (4) The designation made by the submitter... 6 Domestic Security 1 2011-01-01 2011-01-01 false Business information. 5.8 Section 5.8 Domestic... Freedom of Information Act § 5.8 Business information. (a) In general. Business information obtained...

  2. 6 CFR 5.8 - Business information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requirements of Executive Order 12600 (3 CFR, 1988 Comp., p. 235); or (4) The designation made by the submitter... 6 Domestic Security 1 2014-01-01 2014-01-01 false Business information. 5.8 Section 5.8 Domestic... Freedom of Information Act § 5.8 Business information. (a) In general. Business information obtained...

  3. 6 CFR 5.8 - Business information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... requirements of Executive Order 12600 (3 CFR, 1988 Comp., p. 235); or (4) The designation made by the submitter... 6 Domestic Security 1 2012-01-01 2012-01-01 false Business information. 5.8 Section 5.8 Domestic... Freedom of Information Act § 5.8 Business information. (a) In general. Business information obtained...

  4. Discovery of 8-Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)

    PubMed Central

    2015-01-01

    The success of imatinib, a BCR-ABL inhibitor for the treatment of chronic myelogenous leukemia, has created a great impetus for the development of additional kinase inhibitors as therapeutic agents. However, the complexity of cancer has led to recent interest in polypharmacological approaches for developing multikinase inhibitors with low toxicity profiles. With this goal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structure–activity relationship trends that can be exploited in the design of potent kinase inhibitors. One compound, 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x), was found to be the most active, inducing apoptosis of tumor cells at a concentration of approximately 30–100 nM. In vitro kinase profiling revealed that 7x is a multikinase inhibitor with potent inhibitory activity against the CDK4/CYCLIN D1 and ARK5 kinases. Here, we report the synthesis, structure–activity relationship, kinase inhibitory profile, in vitro cytotoxicity, and in vivo tumor regression studies by this lead compound. PMID:24417566

  5. Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).

    PubMed

    Reddy, M V Ramana; Akula, Balireddy; Cosenza, Stephen C; Athuluridivakar, Saikrishna; Mallireddigari, Muralidhar R; Pallela, Venkat R; Billa, Vinay K; Subbaiah, D R C Venkata; Bharathi, E Vijaya; Vasquez-Del Carpio, Rodrigo; Padgaonkar, Amol; Baker, Stacey J; Reddy, E Premkumar

    2014-02-13

    The success of imatinib, a BCR-ABL inhibitor for the treatment of chronic myelogenous leukemia, has created a great impetus for the development of additional kinase inhibitors as therapeutic agents. However, the complexity of cancer has led to recent interest in polypharmacological approaches for developing multikinase inhibitors with low toxicity profiles. With this goal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structure-activity relationship trends that can be exploited in the design of potent kinase inhibitors. One compound, 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x), was found to be the most active, inducing apoptosis of tumor cells at a concentration of approximately 30-100 nM. In vitro kinase profiling revealed that 7x is a multikinase inhibitor with potent inhibitory activity against the CDK4/CYCLIN D1 and ARK5 kinases. Here, we report the synthesis, structure-activity relationship, kinase inhibitory profile, in vitro cytotoxicity, and in vivo tumor regression studies by this lead compound.

  6. 7 CFR 922.6 - Varieties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Varieties. 922.6 Section 922.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE APRICOTS GROWN IN DESIGNATED COUNTIES...

  7. 7 CFR 922.6 - Varieties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Varieties. 922.6 Section 922.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE APRICOTS GROWN IN DESIGNATED COUNTIES...

  8. 7 CFR 922.6 - Varieties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Varieties. 922.6 Section 922.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE APRICOTS GROWN IN DESIGNATED COUNTIES...

  9. 7 CFR 922.6 - Varieties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Varieties. 922.6 Section 922.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE APRICOTS GROWN IN DESIGNATED COUNTIES...

  10. 7 CFR 922.6 - Varieties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Varieties. 922.6 Section 922.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE APRICOTS GROWN IN DESIGNATED COUNTIES...

  11. 7 CFR 985.6 - Producer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Producer. 985.6 Section 985.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE MARKETING ORDER REGULATING THE HANDLING OF SPEARMINT OIL PRODUCED IN THE FAR WEST...

  12. 7 CFR 985.6 - Producer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Producer. 985.6 Section 985.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE MARKETING ORDER REGULATING THE HANDLING OF SPEARMINT OIL PRODUCED IN THE FAR WEST...

  13. 7 CFR 985.6 - Producer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Producer. 985.6 Section 985.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE MARKETING ORDER REGULATING THE HANDLING OF SPEARMINT OIL PRODUCED IN THE FAR WEST...

  14. 7 CFR 923.6 - Varieties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Varieties. 923.6 Section 923.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE SWEET CHERRIES GROWN IN DESIGNATED...

  15. 7 CFR 923.6 - Varieties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Varieties. 923.6 Section 923.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE SWEET CHERRIES GROWN IN DESIGNATED...

  16. 7 CFR 923.6 - Varieties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Varieties. 923.6 Section 923.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE SWEET CHERRIES GROWN IN DESIGNATED...

  17. 7 CFR 923.6 - Varieties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Varieties. 923.6 Section 923.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE SWEET CHERRIES GROWN IN DESIGNATED...

  18. 7 CFR 930.6 - District.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false District. 930.6 Section 930.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE TART CHERRIES GROWN IN THE STATES...

  19. 7 CFR 923.6 - Varieties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Varieties. 923.6 Section 923.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE SWEET CHERRIES GROWN IN DESIGNATED...

  20. 7 CFR 930.6 - District.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false District. 930.6 Section 930.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TART CHERRIES GROWN IN THE STATES...

  1. 7 CFR 930.6 - District.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false District. 930.6 Section 930.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TART CHERRIES GROWN IN THE STATES...

  2. 7 CFR 985.6 - Producer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Producer. 985.6 Section 985.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE MARKETING ORDER REGULATING THE HANDLING OF SPEARMINT OIL PRODUCED IN THE FAR WEST...

  3. 7 CFR 985.6 - Producer.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Producer. 985.6 Section 985.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE MARKETING ORDER REGULATING THE HANDLING OF SPEARMINT OIL PRODUCED IN THE FAR WEST...

  4. 7 CFR 917.6 - Handle.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Handle. 917.6 Section 917.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE FRESH PEARS AND PEACHES GROWN IN...

  5. 7 CFR 917.6 - Handle.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Handle. 917.6 Section 917.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE FRESH PEARS AND PEACHES GROWN IN...

  6. 7 CFR 917.6 - Handle.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Handle. 917.6 Section 917.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE FRESH PEARS AND PEACHES GROWN IN...

  7. 7 CFR 929.6 - Fiscal period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Fiscal period. 929.6 Section 929.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  8. 7 CFR 929.6 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 929.6 Section 929.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  9. 7 CFR 929.6 - Fiscal period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Fiscal period. 929.6 Section 929.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  10. 7 CFR 929.6 - Fiscal period.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Fiscal period. 929.6 Section 929.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  11. 7 CFR 929.6 - Fiscal period.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Fiscal period. 929.6 Section 929.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  12. 7 CFR 905.6 - Producer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Producer. 905.6 Section 905.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ORANGES, GRAPEFRUIT, TANGERINES,...

  13. 7 CFR 905.6 - Producer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Producer. 905.6 Section 905.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ORANGES, GRAPEFRUIT, TANGERINES,...

  14. 7 CFR 905.6 - Producer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Producer. 905.6 Section 905.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ORANGES, GRAPEFRUIT, TANGERINES,...

  15. 7 CFR 905.6 - Producer.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Producer. 905.6 Section 905.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ORANGES, GRAPEFRUIT, TANGERINES,...

  16. 7 CFR 905.6 - Producer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Producer. 905.6 Section 905.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ORANGES, GRAPEFRUIT, TANGERINES,...

  17. 7 CFR 319.37-8 - Growing media.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... growing, storing, and shipping in compliance with 7 CFR 319.37-8(f); and (6) If the accompanying... affecting § 319.37-8, see the List of CFR Sections Affected, which appears in the Finding Aids section of... 7 Agriculture 5 2011-01-01 2011-01-01 false Growing media. 319.37-8 Section 319.37-8...

  18. 7 CFR 319.37-8 - Growing media.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... conditions of growing, storing, and shipping in compliance with 7 CFR 319.37-8(f); and (6) If the... Register citations affecting § 319.37-8, see the List of CFR Sections Affected, which appears in the... 7 Agriculture 5 2014-01-01 2014-01-01 false Growing media. 319.37-8 Section 319.37-8...

  19. 7 CFR 319.37-8 - Growing media.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... conditions of growing, storing, and shipping in compliance with 7 CFR 319.37-8(f); and (6) If the... Register citations affecting § 319.37-8, see the List of CFR Sections Affected, which appears in the... 7 Agriculture 5 2012-01-01 2012-01-01 false Growing media. 319.37-8 Section 319.37-8...

  20. 7 CFR 319.37-8 - Growing media.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... growing, storing, and shipping in compliance with 7 CFR 319.37-8(f); and (6) If the accompanying... affecting § 319.37-8, see the List of CFR Sections Affected, which appears in the Finding Aids section of... 7 Agriculture 5 2010-01-01 2010-01-01 false Growing media. 319.37-8 Section 319.37-8...

  1. 7 CFR 319.37-8 - Growing media.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... conditions of growing, storing, and shipping in compliance with 7 CFR 319.37-8(f); and (6) If the... Register citations affecting § 319.37-8, see the List of CFR Sections Affected, which appears in the... 7 Agriculture 5 2013-01-01 2013-01-01 false Growing media. 319.37-8 Section 319.37-8...

  2. Modeling, Synthesis and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Novel Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254)

    PubMed Central

    Jurutka, Peter W.; Kaneko, Ichiro; Yang, Joanna; Bhogal, Jaskaran S.; Swierski, Johnathon C.; Tabacaru, Christa R.; Montano, Luis A.; Huynh, Chanh C.; Jama, Rabia A.; Mahelona, Ryan D.; Sarnowski, Joseph T.; Marcus, Lisa M.; Quezada, Alexis; Lemming, Brittney; Tedesco, Maria A.; Fischer, Audra J.; Mohamed, Said A.; Ziller, Joseph W.; Ma, Ning; Gray, Geoffrey M.; van der Vaart, Arjan; Marshall, Pamela A.; Wagner, Carl E.

    2014-01-01

    Three unreported analogs of 4-[1-(3,5,5,8,8-pentamethyl-5-6-7-8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), otherwise known as bexarotene, as well as four novel analogs of (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254) are described, and evaluated for their retinoid-X-receptor (RXR)-selective agonism. Compound 1 has FDA approval as a treatment for cutaneous T-cell lymphoma (CTCL); though, treatment with 1 can elicit side-effects by disrupting other RXR-heterodimer receptor pathways. Of the 7 modeled novel compounds, all analogs stimulate RXR-regulated transcription in mammalian-2-hybrid and RXRE-mediated assays, possess comparable or elevated biological activity based on EC50 profiles, and retain similar or improved apoptotic activity in CTCL assays compared to 1. All novel compounds demonstrate selectivity for RXR and minimal crossover onto the retinoic-acid-receptor (RAR) compared to all-trans-retinoic acid, with select analogs also reducing inhibition of other RXR-dependent pathways (e.g., VDR-RXR). Our results demonstrate that further improvements in biological potency and selectivity of bexarotene can be achieved through rational drug design. PMID:24180745

  3. 8 CFR 103.6 - Surety bonds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Surety bonds. 103.6 Section 103.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees § 103.6...

  4. 8 CFR 103.6 - Surety bonds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Surety bonds. 103.6 Section 103.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees § 103.6...

  5. 8 CFR 103.6 - Surety bonds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Surety bonds. 103.6 Section 103.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Applying for Benefits, Surety Bonds, Fees § 103.6...

  6. 33 CFR 8.7 - Information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Information. 8.7 Section 8.7... GUARD RESERVE § 8.7 Information. (a) Information concerning the Coast Guard Reserve may be obtained from Commandant (CG-13), 2100 2nd St. SW., Stop 7801, Washington, DC 20593-7801. (b) Information and...

  7. 28 CFR 8.7 - Judicial forfeiture.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Judicial forfeiture. 8.7 Section 8.7 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.7 Judicial... 5312(a)(3) of title 31 of the United States Code, the Special Agent in Charge of the FBI field...

  8. 28 CFR 8.7 - Judicial forfeiture.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Judicial forfeiture. 8.7 Section 8.7 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.7 Judicial... 5312(a)(3) of title 31 of the United States Code, the Special Agent in Charge of the FBI field...

  9. 28 CFR 8.7 - Judicial forfeiture.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Judicial forfeiture. 8.7 Section 8.7 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.7 Judicial... 5312(a)(3) of title 31 of the United States Code, the Special Agent in Charge of the FBI field...

  10. 33 CFR 8.7 - Information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Information. 8.7 Section 8.7... GUARD RESERVE § 8.7 Information. (a) Information concerning the Coast Guard Reserve may be obtained from Commandant (CG-13), 2100 2nd St. SW., Stop 7801, Washington, DC 20593-7801. (b) Information and...

  11. 33 CFR 8.7 - Information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Information. 8.7 Section 8.7... GUARD RESERVE § 8.7 Information. (a) Information concerning the Coast Guard Reserve may be obtained from Commandant (CG-13), 2100 2nd St. SW., Stop 7801, Washington, DC 20593-7801. (b) Information and...

  12. 33 CFR 8.7 - Information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Information. 8.7 Section 8.7... GUARD RESERVE § 8.7 Information. (a) Information concerning the Coast Guard Reserve may be obtained from Commandant (CG-13), 2100 2nd St. SW., Stop 7801, Washington, DC 20593-7801. (b) Information and...

  13. 33 CFR 8.7 - Information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Information. 8.7 Section 8.7... GUARD RESERVE § 8.7 Information. (a) Information concerning the Coast Guard Reserve may be obtained from Commandant (CG-13), 2100 2nd St. SW., Stop 7801, Washington, DC 20593-7801. (b) Information and...

  14. 22 CFR 8.7 - Security.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Security. 8.7 Section 8.7 Foreign Relations DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.7 Security. (a) All officers and members of a committee must have a security clearance for the subject matter level of security at which the...

  15. 1 CFR 8.7 - Agency cooperation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Agency cooperation. 8.7 Section 8.7 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.7 Agency cooperation. Each agency shall cooperate in keeping publication of...

  16. 1 CFR 8.7 - Agency cooperation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Agency cooperation. 8.7 Section 8.7 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.7 Agency cooperation. Each agency shall cooperate in keeping publication of...

  17. 1 CFR 8.7 - Agency cooperation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Agency cooperation. 8.7 Section 8.7 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.7 Agency cooperation. Each agency shall cooperate in keeping publication of...

  18. 49 CFR 7.8 - Copies

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Copies 7.8 Section 7.8 Transportation Office of the Secretary of Transportation PUBLIC AVAILABILITY OF INFORMATION Information Required To Be Made Public by DOT § 7.8 Copies Copies of any material covered by this subpart that is not published...

  19. 22 CFR 8.7 - Security.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Security. 8.7 Section 8.7 Foreign Relations DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.7 Security. (a) All officers and members of a committee must have a security clearance for the subject matter level of security at which the...

  20. 1 CFR 8.7 - Agency cooperation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Agency cooperation. 8.7 Section 8.7 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.7 Agency cooperation. Each agency shall cooperate in keeping publication of...

  1. 1 CFR 8.7 - Agency cooperation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Agency cooperation. 8.7 Section 8.7 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.7 Agency cooperation. Each agency shall cooperate in keeping publication of...

  2. Are 1,5- and 1,7-dihydrodiimidazo[4,5-b:4‧,5‧-e]pyrazine the main products of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) alkaline hydrolysis? A DFT study of vibrational spectra

    NASA Astrophysics Data System (ADS)

    Kholod, Yana; Okovytyy, Sergiy; Kuramshina, Gulnara; Qasim, Mohammad; Gorb, Leonid; Furey, John; Honea, Patricia; Fredrickson, Herbert; Leszczynski, Jerzy

    2006-08-01

    The fully optimized geometries and force fields of the most stable conformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane and two tautomers 1,5- and 1,7-dihydrodiimidazo[4,5- b:4',5'- e]pyrazine were obtained at the B3LYP level of hybrid density functional theory with the 6-31G(d) basis set. The vibrational frequencies were calculated by scaling of force fields, and the vibrational spectra were interpreted taking into account potential energy distributions. DFT calculations provide good agreement between calculated and experimental vibrational frequencies, obtained for CL-20. The theoretical vibrational spectra of 1,5- and 1,7-dihydrodiimidazo[4,5- b:4',5'- e]pyrazine correspond to the experimental FTIR spectrum obtained for the CL-20 alkaline hydrolysis products.

  3. 5-Demethylnobiletin and 5-Acetoxy-6,7,8,3',4'-pentamethoxyflavone Suppress Lipid Accumulation by Activating the LKB1-AMPK Pathway in 3T3-L1 Preadipocytes and High Fat Diet-Fed C57BL/6 Mice.

    PubMed

    Tung, Yen-Chen; Li, Shiming; Huang, Qingrong; Hung, Wei-Lun; Ho, Chi-Tang; Wei, Guor-Jien; Pan, Min-Hsiung

    2016-04-27

    Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones (HPMFs), such as nobiletin (Nob) and 5-demethylnobiletin (5-OH-Nob), are unique flavonoids that are found exclusively in citrus peels. Nobiletin has been shown to suppress adipogenesis in vitro, but the antiadipogenic activity of 5-OH-Nob has not been investigated. Both nobiletin and 5-OH-Nob have poor aqueous solubility and low oral bioavailability. We employed chemical modification to produce the acetyl derivative of 5-OH-Nob, that is, 5-acetyloxy-6,7,8,3',4'-pentamethoxyflavone (5-Ac-Nob), to improve its bioavailability and bioactive efficiency. We found that 5-Ac-Nob reduced triacylglycerol (TG) content to a greater extent than 5-OH-Nob in 3T3-L1 preadipocytes. Orally administered 5-Ac-Nob resulted in a significant reduction in body weight, intra-abdominal fat, plasma and liver TG levels, and plasma cholesterol level in high fat diet-induced obese male C57BL/6J mice. The 5-Ac-Nob treatment decreased lipid accumulation by triggering the adenosine 5'-monophosphate-activated protein kinase (AMPK) pathway to alter transcriptional factors or lipogenesis-related enzymes in vivo and in vitro. PMID:27041493

  4. Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.

    PubMed

    Oztürk Yildirim, Sema; Butcher, Ray J; Gündüz, Miyase Gözde; El-Khouly, Ahmed; Simşek, Rahime; Safak, Cihat

    2013-01-01

    In the title mol-ecule, C24H28N2O3, the cyclo-hexene ring is in a sofa conformation and the 1,4-dihydro-pyridine ring is in a slight boat conformation. In the indole ring system, the pyrrole and benzene rings form a dihedral angle of 2.63 (7)°. In the crystal, N-H⋯O hydrogen bonds connect the mol-ecules into C(6) chains parallel to the b axis and pairs of weak C-H⋯O hydrogen bonds link inversion-related chains into a ladder motif through R2(2)(18) rings. A weak intra-molecular C-H⋯O hydrogen bond is also observed. PMID:23476426

  5. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commissioner for Examinations as provided in 8 CFR 103.3. (7) Requirements for alien entrepreneurs. An alien... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION...

  6. 8 CFR 244.6 - Application.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... that announces the procedures for TPS registration or re-registration, and 8 CFR 103.2, except as... CFR 103.7(b)(1), 103.16, and 103.17. (b) An applicant for TPS may also request employment authorization pursuant to 8 CFR 274a. Those applicants between the ages of 14 and 65 who are not...

  7. 8 CFR 244.6 - Application.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... that announces the procedures for TPS registration or re-registration, and 8 CFR 103.2, except as... CFR 103.7(b)(1), 103.16, and 103.17. (b) An applicant for TPS may also request employment authorization pursuant to 8 CFR 274a. Those applicants between the ages of 14 and 65 who are not...

  8. 8 CFR 244.6 - Application.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... that announces the procedures for TPS registration or re-registration, and 8 CFR 103.2, except as... CFR 103.7(b)(1), 103.16, and 103.17. (b) An applicant for TPS may also request employment authorization pursuant to 8 CFR 274a. Those applicants between the ages of 14 and 65 who are not...

  9. Moment tensor inversion of the January 8, 2013 (Mw=5.7) and May 24, 2014 (Mw 6.8) North Aegean Earthquakes: seismicity and active tectonics of the North Aegean Region

    NASA Astrophysics Data System (ADS)

    Kalafat, Dogan; Kekovali, Kivanc; Pinar, Ali

    2015-04-01

    The North Aegean Sea is one of the most seismically active and deforming region between the Eurasia and Anatolia tectonic plates. On 8th January 2013 at 14:16 UTC (16:16 local time) a moderate earthquake (Mw= 5.7) occurred between the south of Gökçeada and southwest of Bozcaada Islands. The earthquake was felt at a wide area. Especially felt in the NE Greece south of Lemnos Island and NW Turkey surrounding areas, such as Çanakkale, Marmara Region and Northern Aegean coast as well as to Athens. The area is defined as the continuation of the branch of North Anatolian Fault (NAF) inside the Aegean Sea. Fault plane solution determined by this study shows that the earthquake occurred on NE-SW oriented strike slip fault segment. The aftershocks distribution also supported the rupture of the NE-SW oriented fault. Approximately 17 months later, another big earthquake occurred in the same area. On 24th May 2014, at 09:25 UTC (12:25 local time), a powerful Ml=6.7 (Mw=6.8) earthquake hit Greece and Turkey, 87 km west of Çanakkale, and totally 350 people injured in Greece and Turkey. This earthquake has been strongly felt in Greece, Turkey, Bulgaria, Romania. The main-shock occurred on a fault with a NE-SW strike, where the largest portion of the energy was released towards these directions. Therefore the earthquake was felt strongly in Çanakkale, Istanbul and Marmara region. In this study we calculated CMT solutions for main-shock and important aftershocks (M>4.0). CMT analyses were done for 50 important earthquakes. Moment tensor solutions show generally strike-slip faulting. The fault which caused earthquake, is thought to be a branch of North Anatolian Fault Zone in the North Aegean Sea. Generally, the location of the earthquakes and orientation of the NE-SW nodal planes are consistent with right-lateral faulting within the North Aegean Trough (NAT). The Aegean Sea is characterized by dextral strike-slip faulting along NE-SW striking faults, along fault zones formed

  10. 8 CFR 217.6 - Carrier agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Carrier agreements. 217.6 Section 217.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS VISA WAIVER PROGRAM § 217... may notify a carrier of the existence of a basis for termination of a carrier agreement under...

  11. 8 CFR 217.6 - Carrier agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Carrier agreements. 217.6 Section 217.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS VISA WAIVER PROGRAM § 217... may notify a carrier of the existence of a basis for termination of a carrier agreement under...

  12. 8 CFR 217.6 - Carrier agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Carrier agreements. 217.6 Section 217.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS VISA WAIVER PROGRAM § 217... may notify a carrier of the existence of a basis for termination of a carrier agreement under...

  13. 8 CFR 217.6 - Carrier agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Carrier agreements. 217.6 Section 217.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS VISA WAIVER PROGRAM § 217... may notify a carrier of the existence of a basis for termination of a carrier agreement under...

  14. 8 CFR 217.6 - Carrier agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Carrier agreements. 217.6 Section 217.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS VISA WAIVER PROGRAM § 217... may notify a carrier of the existence of a basis for termination of a carrier agreement under...

  15. 7 CFR 784.8 - Appeals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Appeals. 784.8 Section 784.8 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS 2004 EWE LAMB REPLACEMENT AND RETENTION PAYMENT PROGRAM § 784.8 Appeals. The appeal...

  16. 7 CFR 735.8 - Appeals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Appeals. 735.8 Section 735.8 Agriculture Regulations... REGULATIONS FOR WAREHOUSES REGULATIONS FOR THE UNITED STATES WAREHOUSE ACT General Provisions § 735.8 Appeals. (a) Any person who is subject to an adverse determination made under the Act may appeal...

  17. 7 CFR 784.8 - Appeals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Appeals. 784.8 Section 784.8 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS 2004 EWE LAMB REPLACEMENT AND RETENTION PAYMENT PROGRAM § 784.8 Appeals. The appeal...

  18. 7 CFR 735.8 - Appeals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Appeals. 735.8 Section 735.8 Agriculture Regulations... REGULATIONS FOR WAREHOUSES REGULATIONS FOR THE UNITED STATES WAREHOUSE ACT General Provisions § 735.8 Appeals. (a) Any person who is subject to an adverse determination made under the Act may appeal...

  19. 7 CFR 784.8 - Appeals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Appeals. 784.8 Section 784.8 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS 2004 EWE LAMB REPLACEMENT AND RETENTION PAYMENT PROGRAM § 784.8 Appeals. The appeal...

  20. 8 CFR 1246.7 - Appeals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OF ADJUSTMENT OF STATUS § 1246.7 Appeals. Pursuant to 8 CFR part 1003, an appeal shall lie from a decision of an immigration judge under this part to the Board of Immigration Appeals. An appeal shall be... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Appeals. 1246.7 Section 1246.7 Aliens...

  1. Stable ion study of benzo[a]pyrene (BaP) derivatives: 7,8-dihydro-BaP, 9,10-dihydro-BaP and its 6-halo derivatives, 1- and 3-methoxy-9,10-dihydro-BaP-7(8H)-one, as well as the proximate carcinogen BaP 7,8-dihydrodiol and its dibenzoate, combined with a comparative DNA binding study of regioisomeric (1-, 4-, 2-) pyrenylcarbinols.

    PubMed

    Okazaki, Takao; Laali, Kenneth K; Zajc, Barbara; Lakshman, Mahesh K; Kumar, Subodh; Baird, William M; Dashwood, Wan-Mohaiza

    2003-05-01

    A stable ion study of a series of BaP derivatives is reported. 7,8-Dihydro-BaP 1 gives a persistent bay-region benzyliclike carbocation which shows extensive charge delocalization into the pyrene moiety. In contrast, a "benzylic" carbocation can not be generated from 9,10-dihydro-BaP 2. Introduction of bulky substituents at peri C-6 of 9,10-dihydro-BaP (as in 4 and 5) prevents side reactions (dimerization) to the extent that the initially formed carbocation undergoes rearrangement to generate the corresponding bay-region "benzylic" carbocation as a persistent species. Introduction of methoxy substituents into the 1- or 3-positions of 9,10-dihydro-BaP-7(8H)-one (6,7) increases its electrophilic reactivity to the extent that stable carboxonium-arenium dications are produced in FSO3H-SO2ClF. A detailed NMR study (at 500 MHz) of the resulting mono- and dications is reported, and charge delocalization mode (as well as conformational aspects) are addressed. Other oxidized derivatives of BaP such as the 7,8-dihydrodiol 9 and the 7,8-dihydrodibenzoate 8 are not suitable models for stable ion study because of competing O-protonation (and elimination). Energies for various possible arenium ions and regioisomeric "benzylic" cations were computed by the DFT method at the B3LYP/6-31G(d)//B3LYP/6-31G(d) level or by AM1 for comparison with the experimental results. These findings provide further evidence in support of the stability sequence: 1-pyrenyl > 4-pyrenyl > 2-pyrenyl in alpha-pyrene-substituted carbocations as models for the intermediates arising from BaP-epoxide ring opening. In an effort to provide a parallel, a series of alpha-pyrenylcarbinols were subjected to a DNA binding study using human MCF-7 cells. The results/trends are discussed and compared with the stable ion data.

  2. COMPARISON OF OVERALL METABOLISM OF 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN IN CYP1A2(-/-) KNOCKOUT AND C57BL/6N PARENTAL STRAINS OF MICE

    EPA Science Inventory

    Comparison of Overall Metabolism of 2,3,7,8-TCDD
    in CYP1A2 (-/-) Knockout and C57BL/6N Parental Strains of Mice

    Heldur Hakk* and Janet J. Diliberto**

    * USDA-ARS Biosciences Research Laboratory, P.O. Box 5674, Fargo, ND, USA
    ** US-EPA ORD, National Health Eff...

  3. Long-Term Corrosion Testing of Thermal Spray Coatings of Amorphous Metals: Fe49.7Cr17.7Mn1.9Mo7.4W1.6B15.2C3.8Si2.4 and Fe48Mo14Cr15Y2C15B6

    SciTech Connect

    Farmer, J; Day, D; Lian, T; Saw, C; Hailey, P; Payer, J; Aprigliano, L; Beardsley, B; Branagan, D

    2007-07-09

    Amorphous alloys identified as SAM2X5 (Fe{sub 49.7}Cr{sub 17.7}Mn{sub 1.9}Mo{sub 7.4}W{sub 1.6}B{sub 15.2}C{sub 3.8}Si{sub 2.4}) and SAM1651 (Fe{sub 48}Mo{sub 14}Cr{sub 15}Y{sub 2}C{sub 15}B{sub 6}) have been produced as melt-spun ribbons, drop-cast ingots and thermal-spray coatings. Chromium (Cr), molybdenum (Mo) and tungsten (W) additions provided corrosion resistance, while boron (B) enabled glass formation. Earlier electrochemical studies of melt-spun ribbons and ingots of these amorphous alloys demonstrated outstanding passive film stability. More recently thermal-spray coatings of these amorphous alloys have been made and subjected to long-term salt-fog and immersion tests. Good corrosion resistance has been observed during salt-fog testing. Corrosion rates were measured in situ with linear polarization, while simultaneously monitoring the open-circuit corrosion potentials. Reasonably good performance was observed. The sensitivity of these measurements to electrolyte composition and temperature was determined. The high boron content of SAM2X5 also made it an effective neutron absorber, and suitable for criticality control applications.

  4. 4-(4-Bromo-phen-yl)-7,7-dimethyl-2-methyl-amino-3-nitro-7,8-di-hydro-4H-chromen-5(6H)-one including an unknown solvate.

    PubMed

    Inglebert, S Antony; Kamalraja, Jayabal; Sethusankar, K; Vasuki, Gnanasambandam

    2014-05-01

    In the title compound, C18H19BrN2O4, the chromene unit is not quite planar (r.m.s. deviation = 0.199 Å), with the methyl C atoms lying 0.027 (4) and 1.929 (4) Å from the mean plane of the chromene unit. The six-membered carbocyclic ring of the chromene moiety adopts an envelope conformation, with the dimethyl-substituted C atom as the flap. The methyl-amine and nitro groups are slightly twisted from the chromene moiety, with C-N-C-O and O-N-C-C torsion angles of 2.7 (4) and -0.4 (4)°, respectively. The dihedral angle between the mean plane of the chromene unit and the benzene ring is 85.61 (13)°. An intra-molecular N-H⋯O hydrogen bond generates an S(6) ring motif, which stabilizes the mol-ecular conformation. In the crystal, mol-ecules are linked via N-H⋯O hydrogen bonds, forming hexa-gonal rings lying parallel to the ab plane. A region of disordered electron density, most probably disordered ethanol solvent mol-ecules, occupying voids of ca 432 Å(3) for an electron count of 158, was treated using the SQUEEZE routine in PLATON [Spek (2009 ▶). Acta Cryst. D65, 148-155]. Their formula mass and unit-cell characteristics were not taken into account during refinement. PMID:24860381

  5. 7 CFR 984.8 - Walnuts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Walnuts. 984.8 Section 984.8 Agriculture Regulations... ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE WALNUTS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 984.8 Walnuts. Walnuts means only walnuts of the “English” (Juglans regia)...

  6. 7 CFR 984.8 - Walnuts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Walnuts. 984.8 Section 984.8 Agriculture Regulations... Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE WALNUTS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 984.8 Walnuts. Walnuts means only walnuts of the “English” (Juglans regia)...

  7. 7 CFR 984.8 - Walnuts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Walnuts. 984.8 Section 984.8 Agriculture Regulations... Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE WALNUTS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 984.8 Walnuts. Walnuts means only walnuts of the “English” (Juglans regia)...

  8. 7 CFR 984.8 - Walnuts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Walnuts. 984.8 Section 984.8 Agriculture Regulations... Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE WALNUTS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 984.8 Walnuts. Walnuts means only walnuts of the “English” (Juglans regia)...

  9. 7 CFR 984.8 - Walnuts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Walnuts. 984.8 Section 984.8 Agriculture Regulations... ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE WALNUTS GROWN IN CALIFORNIA Order Regulating Handling Definitions § 984.8 Walnuts. Walnuts means only walnuts of the “English” (Juglans regia)...

  10. 7 CFR 1001.8 - Nonpool plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Nonpool plant. 1001.8 Section 1001.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1001.8 Nonpool plant. See § 1000.8....

  11. 7 CFR 1124.8 - Nonpool plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Nonpool plant. 1124.8 Section 1124.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 1124.8 Nonpool plant. See § 1000.8....

  12. 7 CFR 1001.8 - Nonpool plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Nonpool plant. 1001.8 Section 1001.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1001.8 Nonpool plant. See § 1000.8....

  13. 7 CFR 1033.8 - Nonpool plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Nonpool plant. 1033.8 Section 1033.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1033.8 Nonpool plant. See § 1000.8....

  14. 7 CFR 1005.8 - Nonpool plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Nonpool plant. 1005.8 Section 1005.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1005.8 Nonpool plant. See § 1000.8....

  15. 7 CFR 1131.8 - Nonpool plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Nonpool plant. 1131.8 Section 1131.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1131.8 Nonpool plant. See § 1000.8....

  16. 7 CFR 1033.8 - Nonpool plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Nonpool plant. 1033.8 Section 1033.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1033.8 Nonpool plant. See § 1000.8....

  17. 7 CFR 1006.8 - Nonpool plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Nonpool plant. 1006.8 Section 1006.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1006.8 Nonpool plant. See § 1000.8....

  18. 7 CFR 1032.8 - Nonpool plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Nonpool plant. 1032.8 Section 1032.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1032.8 Nonpool plant. See § 1000.8....

  19. 7 CFR 1032.8 - Nonpool plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Nonpool plant. 1032.8 Section 1032.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1032.8 Nonpool plant. See § 1000.8....

  20. 7 CFR 1007.8 - Nonpool plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Nonpool plant. 1007.8 Section 1007.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1007.8 Nonpool plant. See § 1000.8....

  1. 7 CFR 1131.8 - Nonpool plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Nonpool plant. 1131.8 Section 1131.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1131.8 Nonpool plant. See § 1000.8....

  2. 7 CFR 1126.8 - Nonpool plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Nonpool plant. 1126.8 Section 1126.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1126.8 Nonpool plant. See § 1000.8....

  3. 7 CFR 1006.8 - Nonpool plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Nonpool plant. 1006.8 Section 1006.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1006.8 Nonpool plant. See § 1000.8....

  4. 7 CFR 1005.8 - Nonpool plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Nonpool plant. 1005.8 Section 1005.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1005.8 Nonpool plant. See § 1000.8....

  5. 7 CFR 1030.8 - Nonpool plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Nonpool plant. 1030.8 Section 1030.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1030.8 Nonpool plant. See § 1000.8....

  6. 7 CFR 1030.8 - Nonpool plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Nonpool plant. 1030.8 Section 1030.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1030.8 Nonpool plant. See § 1000.8....

  7. 7 CFR 1126.8 - Nonpool plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Nonpool plant. 1126.8 Section 1126.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1126.8 Nonpool plant. See § 1000.8....

  8. 7 CFR 1007.8 - Nonpool plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Nonpool plant. 1007.8 Section 1007.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1007.8 Nonpool plant. See § 1000.8....

  9. 7 CFR 1124.8 - Nonpool plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Nonpool plant. 1124.8 Section 1124.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Regulating Handling Definitions § 1124.8 Nonpool plant. See § 1000.8....

  10. 7 CFR 1006.8 - Nonpool plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Nonpool plant. 1006.8 Section 1006.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1006.8 Nonpool plant. See § 1000.8....

  11. 7 CFR 1007.8 - Nonpool plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Nonpool plant. 1007.8 Section 1007.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1007.8 Nonpool plant. See § 1000.8....

  12. 7 CFR 1124.8 - Nonpool plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Nonpool plant. 1124.8 Section 1124.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Regulating Handling Definitions § 1124.8 Nonpool plant. See § 1000.8....

  13. 7 CFR 1126.8 - Nonpool plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Nonpool plant. 1126.8 Section 1126.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1126.8 Nonpool plant. See § 1000.8....

  14. 7 CFR 1033.8 - Nonpool plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Nonpool plant. 1033.8 Section 1033.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1033.8 Nonpool plant. See § 1000.8....

  15. 7 CFR 1032.8 - Nonpool plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Nonpool plant. 1032.8 Section 1032.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1032.8 Nonpool plant. See § 1000.8....

  16. 7 CFR 1131.8 - Nonpool plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Nonpool plant. 1131.8 Section 1131.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1131.8 Nonpool plant. See § 1000.8....

  17. 7 CFR 1005.8 - Nonpool plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Nonpool plant. 1005.8 Section 1005.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1005.8 Nonpool plant. See § 1000.8....

  18. 7 CFR 1030.8 - Nonpool plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Nonpool plant. 1030.8 Section 1030.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1030.8 Nonpool plant. See § 1000.8....

  19. 7 CFR 1001.8 - Nonpool plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Nonpool plant. 1001.8 Section 1001.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Handling Definitions § 1001.8 Nonpool plant. See § 1000.8....

  20. 7 CFR 1006.8 - Nonpool plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Nonpool plant. 1006.8 Section 1006.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1006.8 Nonpool plant. See § 1000.8....

  1. 7 CFR 1001.8 - Nonpool plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Nonpool plant. 1001.8 Section 1001.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1001.8 Nonpool plant. See § 1000.8....

  2. 7 CFR 1124.8 - Nonpool plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Nonpool plant. 1124.8 Section 1124.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 1124.8 Nonpool plant. See § 1000.8....

  3. 7 CFR 1131.8 - Nonpool plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Nonpool plant. 1131.8 Section 1131.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1131.8 Nonpool plant. See § 1000.8....

  4. 7 CFR 1006.8 - Nonpool plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Nonpool plant. 1006.8 Section 1006.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1006.8 Nonpool plant. See § 1000.8....

  5. 7 CFR 1032.8 - Nonpool plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Nonpool plant. 1032.8 Section 1032.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1032.8 Nonpool plant. See § 1000.8....

  6. 7 CFR 1126.8 - Nonpool plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Nonpool plant. 1126.8 Section 1126.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1126.8 Nonpool plant. See § 1000.8....

  7. 7 CFR 1126.8 - Nonpool plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Nonpool plant. 1126.8 Section 1126.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1126.8 Nonpool plant. See § 1000.8....

  8. 7 CFR 1124.8 - Nonpool plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Nonpool plant. 1124.8 Section 1124.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 1124.8 Nonpool plant. See § 1000.8....

  9. 7 CFR 1030.8 - Nonpool plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Nonpool plant. 1030.8 Section 1030.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1030.8 Nonpool plant. See § 1000.8....

  10. 7 CFR 1005.8 - Nonpool plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Nonpool plant. 1005.8 Section 1005.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1005.8 Nonpool plant. See § 1000.8....

  11. 7 CFR 1131.8 - Nonpool plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Nonpool plant. 1131.8 Section 1131.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1131.8 Nonpool plant. See § 1000.8....

  12. 7 CFR 1032.8 - Nonpool plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Nonpool plant. 1032.8 Section 1032.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1032.8 Nonpool plant. See § 1000.8....

  13. 7 CFR 1007.8 - Nonpool plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Nonpool plant. 1007.8 Section 1007.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1007.8 Nonpool plant. See § 1000.8....

  14. 7 CFR 1033.8 - Nonpool plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Nonpool plant. 1033.8 Section 1033.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1033.8 Nonpool plant. See § 1000.8....

  15. 7 CFR 1033.8 - Nonpool plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Nonpool plant. 1033.8 Section 1033.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1033.8 Nonpool plant. See § 1000.8....

  16. 7 CFR 1007.8 - Nonpool plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Nonpool plant. 1007.8 Section 1007.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1007.8 Nonpool plant. See § 1000.8....

  17. 7 CFR 1005.8 - Nonpool plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Nonpool plant. 1005.8 Section 1005.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1005.8 Nonpool plant. See § 1000.8....

  18. 7 CFR 1001.8 - Nonpool plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Nonpool plant. 1001.8 Section 1001.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1001.8 Nonpool plant. See § 1000.8....

  19. 7 CFR 1030.8 - Nonpool plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Nonpool plant. 1030.8 Section 1030.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Handling Definitions § 1030.8 Nonpool plant. See § 1000.8....

  20. Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1.

    PubMed

    Garcia-Bates, Tatiana M; Kim, Eun; Concha-Benavente, Fernando; Trivedi, Sumita; Mailliard, Robbie B; Gambotto, Andrea; Ferris, Robert L

    2016-03-15

    The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma has increased in recent decades, though HPV prevention vaccines may reduce this rise in the future. HPV-related cancers express the viral oncoproteins E6 and E7. The latter inactivates the tumor suppressor protein retinoblastoma (Rb), which leads to the overexpression of p16(INK4) protein, providing unique Ags for therapeutic HPV-specific cancer vaccination. We developed potential adenoviral vaccines that express a fusion protein of HPV-16 E6 and E7 (Ad.E6E7) alone or fused with p16 (Ad.E6E7p16) and also encoding an anti-programmed death (PD)-1 Ab. Human monocyte-derived dendritic cells (DC) transduced with Ad.E6E7 or Ad.E6E7p16 with or without Ad.αPD1 were used to activate autologous CD8 CTL in vitro. CTL responses were tested against naturally HPV-infected head and neck squamous cell carcinoma cells using IFN-γ ELISPOT and [(51)Cr]release assay. Surprisingly, stimulation and antitumor activity of CTL were increased after incubation with Ad.E6E7p16-transduced DC (DC.E6E7p16) compared with Ad.E6E7 (DC.E6E7), a result that may be due to an effect of p16 on cyclin-dependent kinase 4 levels and IL-12 secretion by DC. Moreover, the beneficial effect was most prominent when anti-PD-1 was introduced during the second round of stimulation (after initial priming). These data suggest that careful sequencing of Ad.E6E7.p16 with Ad.αPD1 could improve antitumor immunity against HPV-related tumors and that p16 may enhance the immunogenicity of DC, through cyclin-dependent pathways, Th1 cytokine secretion, and by adding a nonviral Ag highly overexpressed in HPV-induced cancers. PMID:26851223

  1. 7 CFR 7.8 - Conduct of community committee elections.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Conduct of community committee elections. 7.8 Section... STABILIZATION AND CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.8 Conduct of community committee elections. (a) The county committee serving at the time shall be responsible for the conduct of...

  2. 7 CFR 7.8 - Conduct of community committee elections.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Conduct of community committee elections. 7.8 Section... STABILIZATION AND CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.8 Conduct of community committee elections. (a) The county committee serving at the time shall be responsible for the conduct of...

  3. 22 CFR 8.6 - Membership.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.6 Membership. (a) The act requires a balanced... committee's functions and should be chosen from different vocations having knowledge in the subject. (b) It..., sex, or color. (c) The committee office will keep the Advisory Committee Management Officer...

  4. 22 CFR 8.6 - Membership.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.6 Membership. (a) The act requires a balanced... committee's functions and should be chosen from different vocations having knowledge in the subject. (b) It..., sex, or color. (c) The committee office will keep the Advisory Committee Management Officer...

  5. 48 CFR 8.406-6 - Disputes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... issued the final decision or the U.S. Court of Federal Claims. (d) Alternative dispute resolution. The contracting officer should use the alternative dispute resolution (ADR) procedures, to the maximum extent... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Disputes. 8.406-6...

  6. 8 CFR 246.7 - Appeals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Appeals. Pursuant to 8 CFR part 3, an appeal shall lie from a decision of an immigration judge under this part to the Board of Immigration Appeals. An appeal shall be taken within 30 days after the mailing of... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Appeals. 246.7 Section 246.7 Aliens...

  7. Extended analysis of the high resolution spectrum of C2H6 near 7 μm: the ν6, ν8, ν4 + ν12, 2ν4 + ν9 vibrational system, and associated hot transitions

    NASA Astrophysics Data System (ADS)

    Lattanzi, F.; di Lauro, C.; Vander Auwera, J.

    2011-09-01

    The room temperature high resolution infrared spectrum of C2H6 between 1330 and 1610 cm-1, the region of the ν6 and ν8 fundamentals, has been re-investigated owing to the relevance of this spectral region in atmospheric and planetary applied research. The assignments of transitions from the ground vibrational state to the upper states ν6, ν8, ν4 + ν12 and 2ν4 + ν9 (4592 in total) and from the lower state ν4 to the upper state ν4 + ν8 (1090 lines) have been considerably extended with respect to our previous work [F. Lattanzi, C. di Lauro and J. Vander Auwera, J. Mol. Spectrosc. 248 (2008) 134-145], especially for the hot transitions. In particular, three new series of perturbation activated transitions were found, with ΔK = ±2, made observable by the resonance of the type l(Δl = ±2, ΔK = ∓1) within ν8. Also, new P-transitions to ν6 were found, made observable by the x,y-Coriolis resonance with ν8, at the values of K from 15 to 18. The extension of the assignments in the high frequency wing of ν8 and their analysis allowed the discovery of two additional resonance interactions. The first interaction, a higher order Coriolis-type between ν8(±K, l = ±1) and ν6(±K ± 2, l = 0), induces a few detectable transitions to ν6 with ΔK = 3. The second interaction, of the type l(Δl = ±2, ΔK = ∓1), comes to resonance between ν8(k = ±19, l = ±1) and 2ν4 + ν9 (k = ±20, l = ∓1). This last resonance and the x,y-Coriolis resonance of ν6 and 2ν4 + ν9 allows one to observe several transitions to the 2ν4 + ν9 vibrational state. The extension of the assignments in the (ν4 + ν8) - ν4 hot band allowed discovery of a resonance interaction of the type l(Δl = ±2, ΔK = ∓1) between the states ν4 + ν8 and 2ν4 + ν12, in addition to their well known Fermi-type interaction. The K-values before and after the level crossing could be determined for both interactions. Better values were also determined for the J-structure parameters B, DJ and

  8. The epithelial-mesenchymal transition induced by keratinocyte growth conditions is overcome by E6 and E7 from HPV16, but not HPV8 and HPV38: Characterization of global transcription profiles

    SciTech Connect

    Azzimonti, Barbara; Dell'Oste, Valentina; Borgogna, Cinzia; Mondini, Michele; Gugliesi, Francesca; De Andrea, Marco; Chiorino, Giovanna; Scatolini, Maria; Ghimenti, Chiara; Landolfo, Santo; Gariglio, Marisa

    2009-06-05

    The aim of this study was to evaluate the growth properties of primary human keratinocytes expressing E6 and E7 proteins, which are from either the beta- or alpha-genotypes, under different culture conditions. We demonstrated that keratinocytes expressing E6 and E7, from both HPV8 and 38, irreversibly underwent the epithelial-mesenchymal transition (EMT) when grown on plastic with FAD medium (F12/DMEM/5%FBS). Expression of E6/E7 from HPV16 was capable of fully overcoming the FAD-induced EMT. Immortalization was only observed in HPV16-transduced cell lines, while the more proliferating phenotype of both KerHPV8 and 38 was mainly related to FAD-induced EMT. Microarray analysis of exponentially growing cells identified 146 cellular genes that were differentially regulated in HPV16 compared to HPV8- and 38-transduced cells. A large accumulation of transcripts associated with epidermal development and differentiation was observed in HPV16-transduced cells, whereas transcripts of genes involved in the extracellular matrix, multicellular organismal processes, and inflammatory response were affected in HPV8 and 38-transduced cells.

  9. Geomorphic and Geophysical Reconnaissance of The Fault Ruptures Associated With The Large Bulgarian Earthquakes of April 14 (m 6.8) and 18 (m 7.0), 1928

    NASA Astrophysics Data System (ADS)

    Vanneste, K.; Verbeeck, K.; Camelbeeck, T.; Shanov, S.; Dimitrov, D.; Nikolov, G.; Kostov, K.

    Seventy-three years after the destructive earthquakes of April 14 and 18, 1928, in the Maritsa valley, Bulgaria, we started reinvestigation of the associated surface ruptures. Contemporary sources describe extensive surface faulting for both events: two con- jugate faults near the village of Chirpan, with a length of 38 and 62 km and vertical displacement of 0.3-0.5 m for the April 14 earthquake, and a 53-km-long fault system near Popovitsa, with vertical displacements of 1.5 m up to 3.5 m for the April 18 earth- quake. Faulting was mostly normal, but comparison with geodetic data indicates that part of the described surface deformation probably corresponds to secondary cracks, rather than to fault scarps. Unfortunately, these faults and cracks were mapped with poor resolution (1/500,000-scale maps), and the landscape was modified dramatically in some places since that time. For that reason, we conducted a geomorphic and geo- physical reconnaissance survey, combined with a re-evaluation of Bulgarian literature, with the aim to identify the surface ruptures in the field, to map them more precisely (on 1/5000-scale topographic maps), and to find suitable sites (where young Quater- nary deposits are present and human perturbation is minimal) for future trenching. We conducted topographic levelling, electric sounding and electric tomography profiles at 7 sites across Chirpan fault and at 9 sites across Popovitsa fault. Thus, we investigated a total fault length of 10.6 km and 5.2 km, respectively. Electric tomography proved to be a powerful tool, not only to confirm or disprove the presence of a fault, but also to obtain a picture of the different geological units on either side of the fault. Along Chirpan fault, the 1928 surface rupture is relatively well preserved, and affects Pale- ogene marine limestone, Miocene-Pliocene lacustrine deposits, and a relatively thin cover of Quaternary slope and river deposits. Three sites are very promising for fur- ther paleoseismic

  10. 7 CFR 1709.8 - Electronic submission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Electronic submission. 1709.8 Section 1709.8... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES General Requirements § 1709.8 Electronic submission... announcement and grant agreements or if other regulations provide for electronic submission. Any...

  11. 7 CFR 1709.8 - Electronic submission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Electronic submission. 1709.8 Section 1709.8... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES General Requirements § 1709.8 Electronic submission... announcement and grant agreements or if other regulations provide for electronic submission. Any...

  12. 7 CFR 8.4 - Basic premises.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Basic premises. 8.4 Section 8.4 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.4 Basic premises. (a) The 4-H Club Name and Emblem are held in trust by the Secretary of Agriculture of the United States Department of...

  13. 7 CFR 8.4 - Basic premises.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Basic premises. 8.4 Section 8.4 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.4 Basic premises. (a) The 4-H Club Name and Emblem are held in trust by the Secretary of Agriculture of the United States Department of...

  14. 7 CFR 8.4 - Basic premises.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Basic premises. 8.4 Section 8.4 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.4 Basic premises. (a) The 4-H Club Name and Emblem are held in trust by the Secretary of Agriculture of the United States Department of...

  15. 7 CFR 8.4 - Basic premises.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Basic premises. 8.4 Section 8.4 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.4 Basic premises. (a) The 4-H Club Name and Emblem are held in trust by the Secretary of Agriculture of the United States Department of...

  16. 7 CFR 8.4 - Basic premises.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Basic premises. 8.4 Section 8.4 Agriculture Office of the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.4 Basic premises. (a) The 4-H Club Name and Emblem are held in trust by the Secretary of Agriculture of the United States Department of...

  17. 7 CFR 1424.8 - Payment amounts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Payment amounts. 1424.8 Section 1424.8 Agriculture... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOENERGY PROGRAM § 1424.8 Payment amounts. (a) An eligible producer may be paid the amount specified in this section, subject to the availability of funds....

  18. 7 CFR 1424.8 - Payment amounts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Payment amounts. 1424.8 Section 1424.8 Agriculture... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOENERGY PROGRAM § 1424.8 Payment amounts. (a) An eligible producer may be paid the amount specified in this section, subject to the availability of funds....

  19. 7 CFR 1424.8 - Payment amounts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Payment amounts. 1424.8 Section 1424.8 Agriculture... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOENERGY PROGRAM § 1424.8 Payment amounts. (a) An eligible producer may be paid the amount specified in this section, subject to the availability of funds....

  20. 7 CFR 226.8 - Audits.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Audits. 226.8 Section 226.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS CHILD AND ADULT CARE FOOD PROGRAM State Agency Provisions § 226.8 Audits. (a)...

  1. 7 CFR 17.8 - Ocean transportation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Ocean transportation. 17.8 Section 17.8 Agriculture... THE AGRICULTURAL TRADE DEVELOPMENT AND ASSISTANCE ACT OF 1954, AS AMENDED § 17.8 Ocean transportation. (a) General. (1) This section applies to the financing of ocean freight or ocean freight...

  2. 7 CFR 17.8 - Ocean transportation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Ocean transportation. 17.8 Section 17.8 Agriculture... THE AGRICULTURAL TRADE DEVELOPMENT AND ASSISTANCE ACT OF 1954, AS AMENDED § 17.8 Ocean transportation. (a) General. (1) This section applies to the financing of ocean freight or ocean freight...

  3. 7 CFR 17.8 - Ocean transportation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Ocean transportation. 17.8 Section 17.8 Agriculture... THE AGRICULTURAL TRADE DEVELOPMENT AND ASSISTANCE ACT OF 1954, AS AMENDED § 17.8 Ocean transportation. (a) General. (1) This section applies to the financing of ocean freight or ocean freight...

  4. 7 CFR 17.8 - Ocean transportation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Ocean transportation. 17.8 Section 17.8 Agriculture... THE AGRICULTURAL TRADE DEVELOPMENT AND ASSISTANCE ACT OF 1954, AS AMENDED § 17.8 Ocean transportation. (a) General. (1) This section applies to the financing of ocean freight or ocean freight...

  5. 7 CFR 1000.8 - Nonpool plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Nonpool plant. 1000.8 Section 1000.8 Agriculture... Definitions § 1000.8 Nonpool plant. Nonpool plant means any milk receiving, manufacturing, or processing plant other than a pool plant. The following categories of nonpool plants are further defined as follows:...

  6. 7 CFR 1000.8 - Nonpool plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Nonpool plant. 1000.8 Section 1000.8 Agriculture... Definitions § 1000.8 Nonpool plant. Nonpool plant means any milk receiving, manufacturing, or processing plant other than a pool plant. The following categories of nonpool plants are further defined as follows:...

  7. 7 CFR 1000.8 - Nonpool plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Nonpool plant. 1000.8 Section 1000.8 Agriculture... Definitions § 1000.8 Nonpool plant. Nonpool plant means any milk receiving, manufacturing, or processing plant other than a pool plant. The following categories of nonpool plants are further defined as follows:...

  8. 7 CFR 1416.8 - Appeals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Appeals. 1416.8 Section 1416.8 Agriculture... General Provisions for 2006 Emergency Agricultural Disaster Assistance Programs § 1416.8 Appeals. The appeal regulations set forth at parts 11 and 780 of this title apply to determinations made pursuant...

  9. 7 CFR 1416.8 - Appeals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Appeals. 1416.8 Section 1416.8 Agriculture... General Provisions for 2006 Emergency Agricultural Disaster Assistance Programs § 1416.8 Appeals. The appeal regulations set forth at parts 11 and 780 of this title apply to determinations made pursuant...

  10. 7 CFR 12.8 - Affiliated persons.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Affiliated persons. 12.8 Section 12.8 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12.8 Affiliated persons. (a) Ineligibility of affiliated persons. Ineligibility of an individual...

  11. 7 CFR 12.8 - Affiliated persons.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Affiliated persons. 12.8 Section 12.8 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12.8 Affiliated persons. (a) Ineligibility of affiliated persons. Ineligibility of an individual...

  12. 7 CFR 12.8 - Affiliated persons.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Affiliated persons. 12.8 Section 12.8 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12.8 Affiliated persons. (a) Ineligibility of affiliated persons. Ineligibility of an individual...

  13. 7 CFR 12.8 - Affiliated persons.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Affiliated persons. 12.8 Section 12.8 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12.8 Affiliated persons. (a) Ineligibility of affiliated persons. Ineligibility of an individual...

  14. 7 CFR 1.8 - Multitrack processing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Multitrack processing. 1.8 Section 1.8 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.8 Multitrack processing. (a) When an agency has a significant number of requests, the nature of which precludes...

  15. 7 CFR 1437.8 - Unit definition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Unit definition. 1437.8 Section 1437.8 Agriculture... Provisions § 1437.8 Unit definition. (a) The unit identifies the interest of the producer in the administrative county on the basis of the unique relationship of the owner to one or more operators. The unit...

  16. 7 CFR 1290.8 - Grant agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Grant agreements. 1290.8 Section 1290.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM § 1290.8 Grant agreements. (a) After review and approval of a grant application, AMS will enter into...

  17. 7 CFR 1291.8 - Grant agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Grant agreements. 1291.8 Section 1291.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM-FARM BILL § 1291.8 Grant agreements. (a) After approval of a grant application, AMS will enter into...

  18. 7 CFR 1291.8 - Grant agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Grant agreements. 1291.8 Section 1291.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM-FARM BILL § 1291.8 Grant agreements. (a) After approval of a grant application, AMS will enter into...

  19. 7 CFR 1290.8 - Grant agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Grant agreements. 1290.8 Section 1290.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM § 1290.8 Grant agreements. (a) After review and approval of a grant application, AMS will enter into...

  20. 7 CFR 3401.8 - Grant awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Grant awards. 3401.8 Section 3401.8 Agriculture... RESEARCH GRANTS PROGRAM General § 3401.8 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make research project grants to those responsible,...

  1. 7 CFR 1291.8 - Grant agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Grant agreements. 1291.8 Section 1291.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM-FARM BILL § 1291.8 Grant agreements. (a) After approval of a grant application, AMS will enter into...

  2. 7 CFR 3401.8 - Grant awards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Grant awards. 3401.8 Section 3401.8 Agriculture... RESEARCH GRANTS PROGRAM General § 3401.8 Grant awards. (a) General. Within the limit of funds available for such purpose, the awarding official shall make research project grants to those responsible,...

  3. 7 CFR 1290.8 - Grant agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Grant agreements. 1290.8 Section 1290.8 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SPECIALTY CROP BLOCK GRANT PROGRAM § 1290.8 Grant agreements. (a) After review and approval of a grant application, AMS will enter into...

  4. 7 CFR 1000.8 - Nonpool plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Nonpool plant. 1000.8 Section 1000.8 Agriculture... Definitions § 1000.8 Nonpool plant. Nonpool plant means any milk receiving, manufacturing, or processing plant other than a pool plant. The following categories of nonpool plants are further defined as follows:...

  5. 7 CFR 1000.8 - Nonpool plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Nonpool plant. 1000.8 Section 1000.8 Agriculture... Definitions § 1000.8 Nonpool plant. Nonpool plant means any milk receiving, manufacturing, or processing plant other than a pool plant. The following categories of nonpool plants are further defined as follows:...

  6. 7 CFR 1.8 - Multitrack processing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Multitrack processing. 1.8 Section 1.8 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.8 Multitrack processing. (a) When an agency has a significant number of requests, the nature of which precludes...

  7. 7 CFR 356.8 - Return procedure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Return procedure. 356.8 Section 356.8 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FORFEITURE PROCEDURES § 356.8 Return procedure. If, at the conclusion...

  8. 7 CFR 3200.8 - Costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Costs. 3200.8 Section 3200.8 Agriculture Regulations... PERSONAL PROPERTY § 3200.8 Costs. Excess personal property obtained under this part is provided free of charge. However, the institution must pay all costs associated with packaging and transportation....

  9. 7 CFR 3200.8 - Costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Costs. 3200.8 Section 3200.8 Agriculture Regulations... PERSONAL PROPERTY § 3200.8 Costs. Excess personal property obtained under this part is provided free of charge. However, the institution must pay all costs associated with packaging and transportation....

  10. 7 CFR 11.8 - Division hearings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Division hearings. 11.8 Section 11.8 Agriculture Office of the Secretary of Agriculture NATIONAL APPEALS DIVISION National Appeals Divison Rules of Procedures § 11.8 Division hearings. (a) General rules. (1) The Director, the Hearing Officer, and...

  11. 7 CFR 1400.8 - Equitable treatment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Equitable treatment. 1400.8 Section 1400.8... AND SUBSEQUENT CROP, PROGRAM, OR FISCAL YEARS General Provisions § 1400.8 Equitable treatment. (a... Administrator deems necessary to provide fair and equitable treatment to such person or legal entity....

  12. 7 CFR 1400.8 - Equitable treatment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Equitable treatment. 1400.8 Section 1400.8... AND SUBSEQUENT CROP, PROGRAM, OR FISCAL YEARS General Provisions § 1400.8 Equitable treatment. (a... Administrator deems necessary to provide fair and equitable treatment to such person or legal entity....

  13. 7 CFR 1400.8 - Equitable treatment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Equitable treatment. 1400.8 Section 1400.8... AND SUBSEQUENT CROP, PROGRAM, OR FISCAL YEARS General Provisions § 1400.8 Equitable treatment. (a... Administrator deems necessary to provide fair and equitable treatment to such person or legal entity....

  14. 7 CFR 1400.8 - Equitable treatment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Equitable treatment. 1400.8 Section 1400.8... AND SUBSEQUENT CROP, PROGRAM, OR FISCAL YEARS General Provisions § 1400.8 Equitable treatment. (a... Administrator deems necessary to provide fair and equitable treatment to such person or legal entity....

  15. 7 CFR 1400.8 - Equitable treatment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Equitable treatment. 1400.8 Section 1400.8... AND SUBSEQUENT CROP, PROGRAM, OR FISCAL YEARS General Provisions § 1400.8 Equitable treatment. (a... Administrator deems necessary to provide fair and equitable treatment to such person or legal entity....

  16. 7 CFR 30.8 - Scrap.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Scrap. 30.8 Section 30.8 Agriculture Regulations of... AND STANDARDS Classification of Leaf Tobacco Covering Classes, Types and Groups of Grades § 30.8 Scrap.... Scrap which accumulates from handling unstemmed leaf tobacco is known as leaf-scrap, and scrap...

  17. 7 CFR 47.8 - The answer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false The answer. 47.8 Section 47.8 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... UNDER THE PERISHABLE AGRICULTURAL COMMODITIES ACT Rules Applicable to Reparation Proceedings § 47.8...

  18. 7 CFR 47.8 - The answer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false The answer. 47.8 Section 47.8 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... UNDER THE PERISHABLE AGRICULTURAL COMMODITIES ACT Rules Applicable to Reparation Proceedings § 47.8...

  19. 7 CFR 226.8 - Audits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Audits. 226.8 Section 226.8 Agriculture Regulations of... NUTRITION PROGRAMS CHILD AND ADULT CARE FOOD PROGRAM State Agency Provisions § 226.8 Audits. (a) Unless otherwise exempt, audits at the State and institution levels must be conducted in accordance with Office...

  20. 7 CFR 1778.8 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 12 2013-01-01 2013-01-01 false 1778.8 Section 1778.8 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) EMERGENCY AND IMMINENT COMMUNITY WATER ASSISTANCE GRANTS § 1778.8...

  1. 7 CFR 1778.8 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false 1778.8 Section 1778.8 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) EMERGENCY AND IMMINENT COMMUNITY WATER ASSISTANCE GRANTS § 1778.8...

  2. 7 CFR 1778.8 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true 1778.8 Section 1778.8 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) EMERGENCY AND IMMINENT COMMUNITY WATER ASSISTANCE GRANTS § 1778.8...

  3. 7 CFR 1778.8 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false 1778.8 Section 1778.8 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) EMERGENCY AND IMMINENT COMMUNITY WATER ASSISTANCE GRANTS § 1778.8...

  4. 7 CFR 1778.8 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 12 2012-01-01 2012-01-01 false 1778.8 Section 1778.8 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) EMERGENCY AND IMMINENT COMMUNITY WATER ASSISTANCE GRANTS § 1778.8...

  5. 7 CFR 3434.8 - Appeals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Appeals. 3434.8 Section 3434.8 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE HISPANIC-SERVING AGRICULTURAL COLLEGES AND UNIVERSITIES CERTIFICATION PROCESS § 3434.8 Appeals. (a) An...

  6. 7 CFR 3434.8 - Appeals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Appeals. 3434.8 Section 3434.8 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE HISPANIC-SERVING AGRICULTURAL COLLEGES AND UNIVERSITIES CERTIFICATION PROCESS § 3434.8 Appeals. (a) An...

  7. 7 CFR 1773.8 - Audit date.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false Audit date. 1773.8 Section 1773.8 Agriculture... (CONTINUED) POLICY ON AUDITS OF RUS BORROWERS RUS Audit Requirements § 1773.8 Audit date. (a) The annual audit must be performed as of the end of the same calendar month each year unless prior approval...

  8. 7 CFR 3402.8 - Fellowship activities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Fellowship activities. 3402.8 Section 3402.8... AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Program Description § 3402.8 Fellowship activities. A USDA Graduate Fellow shall be enrolled as a...

  9. 7 CFR 3402.8 - Fellowship activities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Fellowship activities. 3402.8 Section 3402.8... AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Program Description § 3402.8 Fellowship activities. A USDA Graduate Fellow shall be enrolled as a...

  10. 7 CFR 3402.8 - Fellowship activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Fellowship activities. 3402.8 Section 3402.8... AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Program Description § 3402.8 Fellowship activities. A USDA Graduate Fellow shall be enrolled as a...

  11. 7 CFR 3402.8 - Fellowship activities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Fellowship activities. 3402.8 Section 3402.8... AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Program Description § 3402.8 Fellowship activities. A USDA Graduate Fellow shall be enrolled as a...

  12. 7 CFR 27.8 - Director.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Director. 27.8 Section 27.8 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Administration § 27.8 Director. The Director...

  13. 7 CFR 27.8 - Director.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Director. 27.8 Section 27.8 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Administration § 27.8 Director. The Director...

  14. 7 CFR 27.8 - Director.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Director. 27.8 Section 27.8 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Administration § 27.8 Director. The Director...

  15. 7 CFR 27.8 - Director.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Director. 27.8 Section 27.8 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Administration § 27.8 Director. The Director...

  16. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Classification challenges. 7.30 Section 7.30... INFORMATION Classified Information § 7.30 Classification challenges. (a) Authorized holders of...

  17. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Classification challenges. 7.30 Section 7.30... INFORMATION Classified Information § 7.30 Classification challenges. (a) Authorized holders of...

  18. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Classification challenges. 7.30 Section 7.30... INFORMATION Classified Information § 7.30 Classification challenges. (a) Authorized holders of...

  19. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Classification challenges. 7.30 Section 7.30... INFORMATION Classified Information § 7.30 Classification challenges. (a) Authorized holders of...

  20. 6 CFR 7.30 - Classification challenges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 CFR 7.31. ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Classification challenges. 7.30 Section 7.30... INFORMATION Classified Information § 7.30 Classification challenges. (a) Authorized holders of...

  1. Selective synthesis of [7]- and [8]cycloparaphenylenes.

    PubMed

    Sibbel, Friederike; Matsui, Katsuma; Segawa, Yasutomo; Studer, Armido; Itami, Kenichiro

    2014-01-28

    Cycloparaphenylenes (CPPs) are a remarkable class of hoop-shaped conjugated macrocycles with inimitable properties. Herein we describe a divergent synthesis of [7]CPP and [8]CPP. Furthermore we present the first crystal structure of [7]CPP. Thus, we have now established the size-selective synthesis of [n]CPP (n = 7-16) in a uniformed cyclohexane-based method. PMID:24310620

  2. 8 CFR 286.7 - Penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Penalties. 286.7 Section 286.7 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.7 Penalties. Failure of any air or sea carrier to comply with the provisions of section 286 of the Act and this...

  3. 8 CFR 286.7 - Penalties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Penalties. 286.7 Section 286.7 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.7 Penalties. Failure of any air or sea carrier to comply with the provisions of section 286 of the Act and this...

  4. 8 CFR 286.7 - Penalties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Penalties. 286.7 Section 286.7 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.7 Penalties. Failure of any air or sea carrier to comply with the provisions of section 286 of the Act and this...

  5. 8 CFR 286.7 - Penalties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Penalties. 286.7 Section 286.7 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.7 Penalties. Failure of any air or sea carrier to comply with the provisions of section 286 of the Act and this...

  6. 8 CFR 286.7 - Penalties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Penalties. 286.7 Section 286.7 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.7 Penalties. Failure of any air or sea carrier to comply with the provisions of section 286 of the Act and this...

  7. Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for induction of CYP1A1, CYP1A2 and thymic atrophy in female Harlan Sprague-Dawley rats.

    PubMed

    Hooth, Michelle J; Nyska, Abraham; Fomby, Laurene M; Vasconcelos, Daphne Y; Vallant, Molly; DeVito, Michael J; Walker, Nigel J

    2012-11-15

    In this study we assessed the relative toxicity and potency of the chlorinated naphthalenes 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) and 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) relative to that of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Chemicals were administered in corn oil:acetone (99:1) by gavage to female Harlan Sprague-Dawley rats at dosages of 0 (vehicle), 500, 1500, 5000, 50,000 and 500,000 ng/kg (PCN 66 and PCN 67) and 1, 3, 10, 100, and 300 ng/kg (TCDD) for 2 weeks. Histopathologic changes were observed in the thymus, liver and lung of TCDD treated animals and in the liver and thymus of PCN treated animals. Significant increases in CYP1A1 and CYP1A2 associated enzyme activity were observed in all animals exposed to TCDD, PCN 66 and PCN 67. Dose response modeling of CYP1A1, CYP1A2 and thymic atrophy gave ranges of estimated relative potencies, as compared to TCDD, of 0.0015-0.0072, for PCN 66 and 0.00029-0.00067 for PCN 67. Given that PCN 66 and PCN 67 exposure resulted in biochemical and histopathologic changes similar to that seen with TCDD, this suggests that they should be included in the WHO toxic equivalency factor (TEF) scheme, although the estimated relative potencies indicate that these hexachlorinated naphthalenes should not contribute greatly to the overall human body burden of dioxin-like activity.

  8. [The neuroprotective action of enantiomers and racemate of 2-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)-4-methylthiobutanoic acid].

    PubMed

    Kravchenko, A N; Baranov, V V; Anikina, L V; Vikharev, Iu B; Bushmarinov, I S; Neliubina, Iu V

    2012-01-01

    Neurotropic, neuroprotective and antioxidant actions of the enantiomers and the racemate of 2-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)-4-methylthiobutanoic acid were investigated. Only (+)-(S)-2-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)-4-methylthiobutanoic acid was found to have neuroprotective properties. A distereoselective synthesis of enantiomers and racemate was performed by condensations of (S), (R) and (R,S)-N-carbamoylmethionines with 4,5-dihydroxyimidazolidin-2-one (DHI), respectively. By the X-ray method, the major racemate was proved to crystallize from water as a conglomerate. No antioxidant activity was revealed.

  9. 5,11-Diisopropyl-2,8-dimethyl-1H,7H-diimidazo[c,h][1,6]diazecine dihydrate

    PubMed Central

    Mendoza-Díaz, Guillermo; de Lourdes Betancourt-Mendiola, María; Bernès, Sylvain

    2010-01-01

    Crystals of the title compound, C18H30N6·2H2O, are composed of units of diimidazo[c,h][1,6]diazecine and two water mol­ecules. The asymmetric unit contains one half-molecule of diazecine and one uncoordinated water molecule in a general position. The complete ten-membered heterocycle is generated by an inversion center.The organic residue and water mol­ecules form a two-dimensional hydrogen-bonded network. The 1,6-diazecine ring shows a chair conformation, with angles and distances in normal ranges. PMID:21588282

  10. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  11. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  12. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  13. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  14. 47 CFR 2.108 - Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Policy regarding the use of the fixed-satellite... Allocation, Assignment, and Use of Radio Frequencies § 2.108 Policy regarding the use of the fixed-satellite allocations in the 3.6-3.7, 4.5-4.8, and 5.85-5.925 GHz bands. The use of the fixed-satellite allocations...

  15. Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

    PubMed

    Press, Neil J; Taylor, Roger J; Fullerton, Joseph D; Tranter, Pamela; McCarthy, Clive; Keller, Thomas H; Arnold, Nicola; Beer, David; Brown, Lyndon; Cheung, Robert; Christie, Julie; Denholm, Alastair; Haberthuer, Sandra; Hatto, Julia D I; Keenan, Mark; Mercer, Mark K; Oakman, Helen; Sahri, Helene; Tuffnell, Andrew R; Tweed, Morris; Trifilieff, Alexandre

    2015-09-10

    Herein we describe the optimization of a series of PDE4 inhibitors, with special focus on solubility and pharamcokinetics, to clinical compound 2, 4-(8-(3-fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic acid. Although compound 2 produces emesis in humans when given as a single dose, its exemplary pharmacokinetic properties enabled a novel dosing regime comprising multiple escalating doses and the resultant achievement of high plasma drug levels without associated nausea or emesis. PMID:26288344

  16. Synthesis, Raman and X-ray diffraction investigations of rubidium-doped Gd 1.8Ti 2O 6.7 pyrochlore oxide via a sol-gel process

    NASA Astrophysics Data System (ADS)

    Garbout, A.; Bouattour, S.; Botelho do Rego, A. M.; Ferraria, A.; Kolsi, A. W.

    2007-06-01

    Nanoparticles of rubidium-doped gadolinium titanates oxide were prepared by the sol-gel process from the titanium alcoxyde Ti(OBu) 4 and the two oxides Rb 2CO 3 and Gd 2O 3. Thermal gravimetric (TG) and differential thermal analysis (DTA) results suggest that thermal decomposition of the xerogel takes place when the xerogel is heated at 400 °C. X-ray powder diffraction (XRD) measurements were carried out to study the structure evolution of the sample and to determine the crystalline phases present after heat treatment. A well-crystallized single-phased nanopowder was obtained after calcination at 1000 °C. X-ray diffraction combined to the Raman analysis confirmed the powder's single-phase nature at this temperature. The Rb + did not enter the pyrochlore crystal lattice to substitute Gd 3+ or Ti 4+ as shown by XRD and X-ray photoelectron spectroscopy (XPS). It is probably dispersed uniformly onto gadolinium titanate nanoparticles. Crystal structure of the non-stoichiometry pyrochlore Rb +-doped phase Gd 1.8Ti 2O 6.7, was determined using the Rietveld method. Conductivity analysis shows that the presence of Rb + dopant in Gd 1.8Ti 2O 6.7 leads to an increase of the ionic conductivity compared to the non-doped Gd 1.8Ti 2O 6.7.

  17. 7 CFR 614.8 - Final technical determinations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Final technical determinations. 614.8 Section 614.8 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE CONSERVATION OPERATIONS NRCS APPEAL PROCEDURES § 614.8 Final...

  18. 7 CFR 503.8 - Intoxicating beverages and narcotics.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Intoxicating beverages and narcotics. 503.8 Section 503.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.8...

  19. 7 CFR 503.8 - Intoxicating beverages and narcotics.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Intoxicating beverages and narcotics. 503.8 Section 503.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.8...

  20. 7 CFR 503.8 - Intoxicating beverages and narcotics.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Intoxicating beverages and narcotics. 503.8 Section 503.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.8...

  1. 7 CFR 503.8 - Intoxicating beverages and narcotics.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Intoxicating beverages and narcotics. 503.8 Section 503.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.8...

  2. 7 CFR 503.8 - Intoxicating beverages and narcotics.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Intoxicating beverages and narcotics. 503.8 Section 503.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.8...

  3. 7 CFR 625.8 - Compensation for easements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Compensation for easements. 625.8 Section 625.8..., DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.8 Compensation for easements... section. (d) Acceptance of offered easement compensation. (1) NRCS will not acquire any easement...

  4. 7 CFR 600.8 - Plant materials centers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and...

  5. 7 CFR 600.8 - Plant materials centers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and...

  6. 7 CFR 600.8 - Plant materials centers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and...

  7. 7 CFR 600.8 - Plant materials centers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and...

  8. 7 CFR 600.8 - Plant materials centers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and...

  9. 7 CFR 631.8 - Cost-share rates.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Cost-share rates. 631.8 Section 631.8 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM General Provisions § 631.8...

  10. 7 CFR 631.8 - Cost-share rates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Cost-share rates. 631.8 Section 631.8 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM General Provisions § 631.8...

  11. 7 CFR 631.8 - Cost-share rates.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Cost-share rates. 631.8 Section 631.8 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM General Provisions § 631.8...

  12. 7 CFR 631.8 - Cost-share rates.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Cost-share rates. 631.8 Section 631.8 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING GREAT PLAINS CONSERVATION PROGRAM General Provisions § 631.8...

  13. X-ray studies of 2-amino-4-(3-nitrophenyl)-5-oxo-4,5-dihydropyrano[3,2- c] chromene-3-carbonitrile and 2-amino-7,7-dimethyl-4-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4 H-chromene-3-carbonitrile

    NASA Astrophysics Data System (ADS)

    Sharma, S.; Banerjee, B.; Brahmachari, G.; Kant, R.; Gupta, V. K.

    2015-12-01

    Two carbonitrile compounds, 2-amino-4-(3-nitrophenyl)-5-oxo-4,5-dihydropyrano[3,2- c] chromene-3-carbonitrile ( I) and 2-amino-7,7-dimethyl-4-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4 H-chromene-3-carbonitrile ( II), were synthesized, and their crystal structures were determined by X-ray diffraction technique. The crystals are triclinic, a = 7.7970(12), 8.2171(7), b = 9.0390(10), 9.2238(7), c = 15.148(2), 14.5585(11) Å, α = 81.439(10)°, 74.895(6)°, β = 75.194(12)°, 87.392(6)°, γ = 76.151(11)°, 78.552(7)°, for I and II, respectively, Z = 2, sp. gr. P overline 1. The pyran ring in both the compounds deviates significantly from planarity and adopts boat conformation. The crystal structure is stabilized by N-H···O and N-H···N hydrogen bonds.

  14. 7 CFR 27.8 - Director.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Director. 27.8 Section 27.8 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS...

  15. 7 CFR 246.8 - Nondiscrimination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Nondiscrimination. 246.8 Section 246.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SPECIAL SUPPLEMENTAL NUTRITION PROGRAM FOR WOMEN, INFANTS AND CHILDREN Participant Eligibility §...

  16. 7 CFR 246.8 - Nondiscrimination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Nondiscrimination. 246.8 Section 246.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SPECIAL SUPPLEMENTAL NUTRITION PROGRAM FOR WOMEN, INFANTS AND CHILDREN Participant Eligibility §...

  17. 7 CFR 1230.8 - Delegate Body.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Delegate Body. 1230.8 Section 1230.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Body. Delegate Body means the National Pork Producers Delegate Body established pursuant to § 1230.30....

  18. 7 CFR 1230.8 - Delegate Body.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Delegate Body. 1230.8 Section 1230.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Body. Delegate Body means the National Pork Producers Delegate Body established pursuant to § 1230.30....

  19. 7 CFR 275.8 - Review coverage.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Review coverage. 275.8 Section 275.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM PERFORMANCE REPORTING SYSTEM Management Evaluation...

  20. 7 CFR 1215.8 - Industry information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Industry information. 1215.8 Section 1215.8... Industry information. Industry information means information and programs that will lead to the development of new markets, new marketing strategies, or increased efficiency for the popcorn industry,...

  1. 7 CFR 1215.8 - Industry information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Industry information. 1215.8 Section 1215.8... Industry information. Industry information means information and programs that will lead to the development of new markets, new marketing strategies, or increased efficiency for the popcorn industry,...

  2. 7 CFR 1215.8 - Industry information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Industry information. 1215.8 Section 1215.8... Industry information. Industry information means information and programs that will lead to the development of new markets, new marketing strategies, or increased efficiency for the popcorn industry,...

  3. 7 CFR 1215.8 - Industry information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Industry information. 1215.8 Section 1215.8... Industry information. Industry information means information and programs that will lead to the development of new markets, new marketing strategies, or increased efficiency for the popcorn industry,...

  4. Ultrasound Mediated One-Pot, Three Component Synthesis, Docking and ADME Prediction of Novel 5-Amino-2-(4-chlorophenyl)-7-Substituted Phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile Derivatives as Anticancer Agents.

    PubMed

    Tiwari, Shailee V; Seijas, Julio A; Vazquez-Tato, M Pilar; Sarkate, Aniket P; Lokwani, Deepak K; Nikalje, Anna Pratima G

    2016-01-01

    Herein, we report an environmentally friendly, rapid, and convenient one-pot ultrasound-promoted synthesis of 5-amino-2-(4-chlorophenyl)-7-substituted phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile derivatives. The in-vitro anticancer activities of these compounds were evaluated against four human tumor cell lines. Among all the synthesized derivatives, compound 4i, which has substituent 3-hydroxy-4-methoxyphenyl is found to have the highest GI50 value of 32.7 μM, 55.3 μM, 34.3 μM, 28.9 μM for MCF-7, K562, HeLa and PC-3 cancer cell lines respectively. A docking study of the newly synthesized compounds were performed, and the results showed good binding mode in the active site of thymidylate synthase enzyme. ADME properties of synthesized compounds were also studied and showed good drug like properties. PMID:27483213

  5. Synthesis and structural study of 4-(2-chlorophenyl)-2-ethoxy-5,6,7,8,9,10-hexahydrocycloocta[B]pyridine-3-carbonitrile

    NASA Astrophysics Data System (ADS)

    Fathima, K. Saiadali; Vasumathi, M.; Anitha, K.

    2016-05-01

    The novel organic material C20H21ClN2O was synthesized by One-Pot synthesis method and the single crystals were grown by slow evaporation solution growth technique. The crystal structure was elucidated by subjecting the grown crystals to the single crystal x-ray diffraction analysis and was refined by full matrix least-squares method to R=0.039 for 2746 reflections. Crystal system of the grown crystal was found to be monoclinic with the space group P21/a and a=9.196(4) Å, b=13.449(4) Å, c=14.818(4) Å, β= 101.542(3)°, V=1795.6(11) Å3 and Z=4. In this crystal structure, cyclooctanone prefers to reside in a chair-boat conformation. The structure is stabilized by attractive molecular force such as CH/π interaction called hydrophobic interaction.

  6. Vocational Consumer Education: Homemaking, Grades 6-8.

    ERIC Educational Resources Information Center

    West, Doris; And Others

    This curriculum guide presents a sequential program for Grades 6, 7, and 8 in vocational homemaking education in the Fort Worth, Texas, public schools. Concepts, behavioral objectives, generalization, and learning experiences are shown for nutrition and meal management, consumer education, home management and housing, family living, child…

  7. Energy and My Environment. Teachers' Guide, 6-8.

    ERIC Educational Resources Information Center

    Brennan, Matthew J.; And Others

    Energy activities and lesson plans for grades 6, 7, and 8 (grouped into seven units representing seven major conceptual schemes) are provided in this teachers' guide, with a unit at each grade level for each conceptual scheme. Conceptual schemes addressed include: (1) energy is the ability to do work; (2) energy comes from the sun; (3) energy can…

  8. 7 CFR 761.6 - Appeals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... PROGRAMS GENERAL PROGRAM ADMINISTRATION General Provisions § 761.6 Appeals. Except as provided in 7 CFR part 762, appeal of an adverse decision made by the Agency will be handled in accordance with 7 CFR... 7 Agriculture 7 2011-01-01 2011-01-01 false Appeals. 761.6 Section 761.6 Agriculture...

  9. Electron-impact excitation of the Rb 7 2S1/2, 8 2S1/2, 5 2D3/2, and 6 2D3/2 states

    NASA Astrophysics Data System (ADS)

    Wei, Zuyi; Flynn, Connor; Redd, Aaron; Stumpf, Bernhard

    1993-03-01

    Electron-impact cross sections for excitation of the 7 2S1/2, 8 2S1/2, 5 2D3/2, and 6 2D3/2 states of rubidium have been measured from threshold to 1000 eV. The optical-excitation-function method has been employed in a crossed atom- and electron-beam apparatus. Relative, total (cascade including) experimental cross sections are made absolute by comparison with the known total cross section of the Rb D1 line. Total excitation cross sections are compared with theoretical calculations employing first Born approximation and theoretical branching ratios. Born cross sections for the 7 2S1/2 and 8 2S1/2 states are obtained from the literature, while Born cross sections for the 5 2D3/2, 6 2D3/2, and all cascading states are calculated in this paper. At high energies, the measured total 2D3/2 state cross sections show 1/E behavior and converge to first Born theory; for E>100 eV, experiment and theory agree within 6.7% for 5 2D3/2 and within 3.7% for 6 2D3/2. The total cross sections for the 2S1/2 states do not converge to Born theory even at 1000 eV, and it is shown that this cannot be attributed to cascading. At low energies, 2S1/2 and 2D3/2 state total excitation cross sections have similar shapes with sharply peaked maxima at about 0.9 eV above threshold. After cascading is corrected using first Born theory, estimated experimental cross sections for direct excitation of higher fine-structure states of rubidium are given.

  10. Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines.

    PubMed

    Faessel, H M; Slocum, H K; Rustum, Y M; Greco, W R

    1999-03-01

    Folic acid (PteGlu)-enhanced intense synergy has been observed between nonpolyglutamylatable dihydrofolate reductase (DHFR) inhibitors and polyglutamylatable inhibitors of other folate-requiring enzymes, such as glycinamide ribonucleotide formyltransferase (GARFT) and thymidylate synthase. Since this phenomenon is potentially therapeutically useful, we explored its universality by examining the combined action of a DHFR inhibitor, trimetrexate (TMQ), with a GARFT inhibitor, 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]++ +thiazin-6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034), in eight human cultured cell lines. Using a 96-well plate cell growth inhibition assay, four ileocecal adenocarcinoma cell lines [HCT-8, HCT-8/DW2 (Tomudex-resistant), HCT-8/DF2 (Tomudex-/FdUrd-resistant), and HCT-8/50 (adapted to 50 nM PteGlu)], three head and neck carcinoma cell lines [A253, FaDu, and Hep-2/500 (FdUrd-resistant)], and a non-small cell lung carcinoma cell line [H460] were treated for 96 hr with TMQ + AG2034 in the presence of 23 or 40 microM PteGlu. Cell growth was measured with the sulforhodamine B assay at the end of this period. Drug interactions were assessed by fitting a 7-parameter model including a synergism parameter, alpha, to data with weighted nonlinear regression. Isobologram analysis was also applied. At 23 microM PteGlu, cells exhibited similar intensities of Loewe synergy for the combination of TMQ + AG2034. Loewe synergy was abolished in HCT-8/50 cells cultured and studied in 50 nM PteGlu. At 40 microM PteGlu, the intensity of the combined action in all cell lines was increased However, the most intense Loewe synergy was seen with HCT-8, HCT-8/DF2, H460, FaDu, A253, and Hep-2/500 cells, whereas the HCT-8/50 subculture showed less of the phenomenon, and PteGlu enhancement was the least with HCT-8/DW2, a subline deficient in folylpolyglutamate synthetase (FPGS). The universality of the PteGlu-enhanced intense synergy phenomenon

  11. 7 CFR 7.6 - Determination of elective areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Determination of elective areas. 7.6 Section 7.6 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF AGRICULTURAL STABILIZATION AND CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.6 Determination of elective areas. (a)...

  12. Fragrance material review on 1-[5(or 6)-methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one.

    PubMed

    Scognamiglio, J; Letizia, C S; Api, A M

    2013-12-01

    A toxicologic and dermatologic review of 1-[5(Or 6)-Methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one when used as a fragrance ingredient is presented. 1-[5(Or 6)-Methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1-[5(Or 6)-Methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, phototoxicity, photoallergy, and genotoxicity, data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al., Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A Toxicologic and Dermatologic Assessment of Alkyl Cyclic Ketones When Used as Fragrance Ingredients. (submitted for publication)). for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances.

  13. 7 CFR 502.8 - Intoxicating beverages and narcotics.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Intoxicating beverages and narcotics. 502.8 Section..., MARYLAND § 502.8 Intoxicating beverages and narcotics. Entering BARC property or the operation of a motor vehicle thereon, by a person under the influence of intoxicating beverages or narcotic drug,...

  14. 7 CFR 502.8 - Intoxicating beverages and narcotics.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Intoxicating beverages and narcotics. 502.8 Section..., MARYLAND § 502.8 Intoxicating beverages and narcotics. Entering BARC property or the operation of a motor vehicle thereon, by a person under the influence of intoxicating beverages or narcotic drug,...

  15. 7 CFR 502.8 - Intoxicating beverages and narcotics.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Intoxicating beverages and narcotics. 502.8 Section..., MARYLAND § 502.8 Intoxicating beverages and narcotics. Entering BARC property or the operation of a motor vehicle thereon, by a person under the influence of intoxicating beverages or narcotic drug,...

  16. 7 CFR 502.8 - Intoxicating beverages and narcotics.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Intoxicating beverages and narcotics. 502.8 Section..., MARYLAND § 502.8 Intoxicating beverages and narcotics. Entering BARC property or the operation of a motor vehicle thereon, by a person under the influence of intoxicating beverages or narcotic drug,...

  17. 7 CFR 502.8 - Intoxicating beverages and narcotics.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Intoxicating beverages and narcotics. 502.8 Section..., MARYLAND § 502.8 Intoxicating beverages and narcotics. Entering BARC property or the operation of a motor vehicle thereon, by a person under the influence of intoxicating beverages or narcotic drug,...

  18. Suzuki-Miyaura and Stille reactions as key steps in the synthesis of diversely functionalized Amaryllidaceae alkaloid analogs bearing a 5,6,7,8-tetrahydrobenzo[c,e]azocine skeleton.

    PubMed

    Appukkuttan, Prasad; Dehaen, Wim; Van der Eycken, Erik

    2007-11-01

    Microwave-assisted Suzuki-Miyaura and Stille cross-coupling reactions for the synthesis of highly electron-rich and diversely functionalized biaryl intermediates are presented. Microwave-irradiation has been demonstrated to be a very powerful tool for performing difficult transition metal-catalyzed cross-coupling reactions with unfavorably substituted coupling partners. The key biaryl intermediates were used for the microwave-enhanced construction of the 5,6,7,8-tetrahydrobenzo[c,e]azocine skeleton of the Apogalanthamine analogs. The success of the strategy is demonstrated by synthesizing a number of hitherto unknown, diversely functionalized, natural product analogs.

  19. 6i7H8JSg

    NASA Astrophysics Data System (ADS)

    Gimeno, Teresa; O'Grady, Anthony; McVicar, Tim; Tissue, David; Ellsworth, David

    2014-05-01

    Atmospheric CO2 concentration (Ca) is rising at an unprecedented rate, nowadays nearing 400 ppm. Rising levels of Ca directly affect plant functioning and these effects cascade into all the rest of the ecosystem. A major mechanism for this is through stomatal closure in response to elevated Ca , which should result into increased soil moisture availability. The water savings lead to increased soil water storage in the deeper soil layers and ultimately increase surface runoff. The hypothesised water savings phenomenon is hotly debated, since the reduction in transpiration per unit of foliar area could be counterbalance by an increase in leaf area index (LAI) or increased understorey transpiration. To address these hypotheses, we conducted a large-scale CO2 enrichment experiment (FACE) in a water-limited ecosystem in Australia. We quantified the impact of elevated Ca on ecosystem water use and storage within the EucFACE experiment. The EucFACE experiment (Eucalyptus Free Air CO2 Enrichment) is the first of its kind established on a native old growth woodland, a remnant patch of native Cumberland plain woodland west of Sydney (Australia). The experiment consists of six 25 m diameter cylindrical arrays ('rings'). The vegetation within three of the rings is exposed to a Ca of 150 ppm above ambient. To assess the impact of elevated Ca on the different ecosystem components we monitor: soil moisture availability (from 25 to 450 cm depth), canopy transpiration (on the one major canopy forming species: Eucalyptus tereticornis), LAI, ground water oscillations, canopy interception, stemflow and understorey transpiration. We ask here whether canopy transpiration is altered by elevated Ca, and whether soil moisture dynamics have changed during the early stages of the experiment. We found reduced stomatal conductance to water vapour under elevated Ca, though this depended on soil water availability and prevailing temperature. Stomatal closure resulted in a small seasonal reduction of transpiration at the whole canopy level, only under moist conditions. Vegetation water savings under elevated Ca translated into greater moisture availability in the shallow soil during relatively moist periods whereas this effect disappeared after a sustained period without precipitation. Finally we found that during a dry period, in the deeper soil layers (200-350 cm), soil moisture gradually decreased more under ambient than under elevated Ca. Overall, these results suggest that elevated C¬a will not produce water savings during drought, but will under high and medium water availability. According to our preliminary analyses, we propose that these water savings will translate into increased soil water storage at the deeper layers.

  20. 7,8-Secolignans from the fruits of Schisandra neglecta.

    PubMed

    Wang, Huan; Yang, Juan-Xia; Lou, Jie; Liu, Gui-You; Li, Li-Mei; Sun, Han-Dong; Xiao, Wei-Lie; Hu, Qiu-Fen; Gao, Xue-Mei

    2015-01-01

    Two new 7,8-secolignans, neglectahenols E and F (1 and 2), together with four known 7,8-secolignans (3-6), were isolated from the fruits of Schisandra neglecta. The structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-6 were tested for their anti-tobacco mosaic virus (anti-TMV) activities at the concentration of 20 μM. Compounds 1 and 6 showed high anti-TMV activities with inhibition rates of 38.2% and 32.7%, respectively. These rates are higher than that of a positive control. Compounds 2-5 also showed modest anti-TMV activities with inhibition rates in the range of 22.8-28.7%. These rates are close to that of a positive control.

  1. Electrochemical Studies of Passive Film Stability on Fe49.7Cr17.7Mn1.9Mo7.4W1.6B15.2C3.8Si2.4 Amorphous Metal in Seawater at 90oCElectrochemical Studies of Passive Film Stability on Fe49.7Cr17.7Mn1.9Mo7.4W1.6B15.2C3.8Si2.4 Amorphous Metal in Seawater at 9

    SciTech Connect

    Farmer, J C; Haslam, J; Day, S D; Lian, T; Saw, C K; Hailey, P D; Choi, J S; Rebak, R B; Yang, N; Payer, J H; Perepezko, J H; Hildal, K; Lavernia, E J; Ajdelsztajn, L; Branagan, D J; Buffa, E J; Aprigliano, L F

    2007-04-25

    An iron-based amorphous metal, Fe{sub 49.7}Cr{sub 17.7}Mn{sub 1.9}Mo{sub 7.4}W{sub 1.6}B{sub 15.2}C{sub 3.8}Si{sub 2.4} (SAM2X5), with very good corrosion resistance was developed. This material was prepared as a melt-spun ribbon, as well as gas atomized powder and a thermal-spray coating. During electrochemical testing in several environments, including seawater at 90 C, the passive film stability was found to be comparable to that of high-performance nickel-based alloys, and superior to that of stainless steels, based on electrochemical measurements of the passive film breakdown potential and general corrosion rates. This material also performed very well in standard salt fog tests. Chromium (Cr), molybdenum (Mo) and tungsten (W) provided corrosion resistance, and boron (B) enabled glass formation. The high boron content of this particular amorphous metal made it an effective neutron absorber, and suitable for criticality control applications. This material and its parent alloy maintained corrosion resistance up to the glass transition temperature, and remained in the amorphous state during exposure to relatively high neutron doses.

  2. 7 CFR 29.3111 - Rule 8.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Rule 8. 29.3111 Section 29.3111 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... shall be considered. Minor irregularities which do not affect over one percent of the tobacco shall...

  3. Mathematics 7-8 Handbook, 1976 Reprint.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Bureau of General Education Curriculum Development.

    This handbook, prepared for teachers of grades 7 and 8, provides suggestions for teaching various aspects of the mathematics courses outlined in the syllabus of the New York State Education Department. The handbook deals with twelve units: sets, systems of numeration, natural numbers, whole numbers, positive rationals, integers, the complete set…

  4. 7 CFR 783.8 - Multiple benefits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... loans or payments resulting from purchase of the additional coverage insurance, as defined in 7 CFR 400... SPECIAL PROGRAMS TREE ASSISTANCE PROGRAM § 783.8 Multiple benefits. Persons may not receive or retain payments for production losses from trees, vines and bushes under this part if they have been...

  5. DFT studies on a high-energy density cage compound 1, 3, 5, 7, 9, 11-hexo(N(CH3)NO2)-2, 4, 6, 8, 10, 12-hexaazatetracyclo[5, 5, 0, 0, 0] dodecane

    NASA Astrophysics Data System (ADS)

    Li, Xiao-Hong; Yong, Yong-Liang; Zhang, Xian-Zhou

    2014-04-01

    The infrared and Raman spectra, heat of formation (HOF) and thermodynamic properties were investigated by B3LYP/6-31G** method for a new designed polynitro cage compound 1,3,5,7,9,11-hexo(N(CH3)NO2)-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0,0]dodecane. The detonation velocity (D) and pressure (P) were predicted by the Kamlet-Jacobs equations based on the theoretical density and condensed HOF. The bond dissociation energies and bond orders for the weakest bonds were analysed to investigate the thermal stability of the title compound. The computational result shows that the detonation velocity and pressure of the title compound are superior to those of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), but inferior to those of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX) and hexanitrohexaazaisowurtzitane (HNIW). And the analysis of thermal stability shows that the first step of pyrolysis is the rupture of the N7-NO2 bond. The crystal structure obtained by molecular mechanics belongs to the P21 space group, with the lattice parameters Z = 2, a = 11.8246 Å, b = 10.4632 Å, c = 15.9713 Å, ρ = 1.98 g cm-3.

  6. 29 CFR 6.7 - Appearances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Appearances. 6.7 Section 6.7 Labor Office of the Secretary of Labor RULES OF PRACTICE FOR ADMINISTRATIVE PROCEEDINGS ENFORCING LABOR STANDARDS IN FEDERAL AND FEDERALLY ASSISTED CONSTRUCTION CONTRACTS AND FEDERAL SERVICE CONTRACTS General § 6.7 Appearances....

  7. ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF 8-METHOXY-1,3-DIMETHYL-2,6-DIOXO-PURIN-7-YL DERIVATIVES WITH TERMINAL CARBOXYLIC, ESTER OR AMIDE MOIETIES IN ANIMAL MODELS.

    PubMed

    Zygmunt, Małgorzata; Chłon-Rzepa, Grazyna; Wyska, Elzbieta; Pociecha, Krzysztof; Sapa, Jacek

    2016-01-01

    The previous studies in a series of 8-methoxy-1,3-dimethyl-2,6-dioxo-purin-7-yl derivatives revealed their analgesic properties. We extended the study with these compounds in aim to assess their impact on inflammatory process. For this purpose we used: the zymosan-induced peritonitis and the carrageenan-induced edema model. Furthermore, the antioxidant activity of the investigated compounds by the FRAP assay was determined. For the most active derivatives from evaluated series their influence on plasma TNF-α level was also tested in vivo. All investigated purine-2,6-dione derivatives 1-11 decreased neutrophils count and inhibited intensity of early vascular permeability. Furthermore, all evaluated compounds reduced the volume of edema caused by subcutaneous injection of carrageenan. Derivatives 1 (with ester moiety), 3 and 4 (with carboxylic group) showed the highest activity in the zymosan-induced peritonitis. In addition, a significant inhibition of plasma TNF-α level in rats with endotoxemia was observed following intraperitoneal administration of these compounds. In turn, compounds 6 and 8-11 containing amide moiety showed the greatest anti-inflammatory (antiedematous) effect in the carrageenan-induced paw edema model. All compounds did not show significant antioxidant properties. The present studies revealed that the presented purine-2,6-dione derivatives exhibit a significant anti-inflammatory activity and this effect may result from their ability to lower TNF-α level. PMID:27476295

  8. 7 CFR 761.6 - Appeals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... provided in 7 CFR part 762, appeal of an adverse decision made by the Agency will be handled in accordance with 7 CFR parts 11 and 780. ... 7 Agriculture 7 2012-01-01 2012-01-01 false Appeals. 761.6 Section 761.6 Agriculture...

  9. Controlling the molecular weights of polyethylene waxes using the highly active precatalysts of 2-(1-aryliminoethyl)-9-arylimino-5,6,7,8-tetrahydrocycloheptapyridylcobalt chlorides: synthesis, characterization, and catalytic behavior.

    PubMed

    Huang, Fang; Zhang, Wenjuan; Yue, Erlin; Liang, Tongling; Hu, Xinquan; Sun, Wen-Hua

    2016-01-14

    A series of 2-(1-aryliminoethyl)-9-arylimino-5,6,7,8-tetrahydrocycloheptapyridylcobalt chlorides were synthesized and characterized using FT-IR and elemental analysis, and the molecular structures of complexes , and were confirmed to present a pseudo-square-pyramidal or trigonal-bipyramidal geometry around the cobalt center using single-crystal X-ray diffraction. Upon activation with either methylaluminoxane (MAO) or modified methylaluminoxane (MMAO), all cobalt precatalysts gave high activities up to the level of 10(7) gPE mol(-1) (Co) h(-1) toward ethylene polymerization, being one of most active cobalt-based precatalysts. In comparison with cobalt analogues, the title precatalysts generally possessed longer lifetime along with good thermo-stability; moreover, the resultant polyethylenes were highly linear and unimodal in most cases. PMID:26619038

  10. New lithium copper borates with BO3 triangles: Li6CuB4O10, Li3CuB3O7, Li8Cu7B14O32, and Li2Cu9B12O28.

    PubMed

    Kuratieva, N V; Bànki, M; Tsirlin, A A; Eckert, J; Ehrenberg, H; Mikhailova, D

    2013-12-16

    Crystal structures of three new lithium copper borates, Li3CuB3O7, Li8Cu7B14O32, and Li2Cu9B12O28, and a new Li6CuB4O10 polymorph were solved by single-crystal X-ray diffraction. In all of the structures, the boron cations form BO3 triangles, which are connected with each other and with copper polyhedra only via corners in Li6CuB4O10 and Li3CuB3O7 and via both corners and edges in Li8Cu7B14O32 and Li2Cu9B12O28. The Li3CuB3O7 and Li8Cu7B14O32 compounds were synthesized as pure samples with only trace amounts of impurities; hence, their magnetic properties could be investigated and analyzed in terms of underlying magnetic couplings. Other compositions always represented multiphase mixtures. Li3CuB3O7 features infinite Cu,O chains formed by Cu2O6 units consisting of edge-shared CuO4 squares. Together with two apical oxygen atoms with long interatomic Cu-O distances of 2.7-2.8 Å, the Cu2O6 units form chains extended along the a axis. These pseudochains are responsible for strong anisotropic thermal expansion behavior. The temperature dependence of the magnetization between 4 and 380 K for Li3CuB3O7 could be fit well by a spin-dimer model. The magnetic susceptibility of Li8Cu7B14O32 showed a more complex temperature dependence, with two different Curie-Weiss regimes in the temperature range of 2-380 K. PMID:24266792

  11. 7 CFR 1720.6 - Application process.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... application to the Secretary; (2) The application is screened by RUS pursuant to 7 CFR 1720.7(a) of this part... the selection criteria set forth in 7 CFR 1720.7(b) of this part; (4) If RUS provisionally approves... 7 Agriculture 11 2014-01-01 2014-01-01 false Application process. 1720.6 Section...

  12. Computational studies on the crystal structure, thermodynamic properties, detonation performance, and pyrolysis mechanism of 2,4,6,8-tetranitro-1,3,5,7-tetraazacubane as a novel high energy density material.

    PubMed

    Wang, Fang; Du, Hongchen; Zhang, Jianying; Gong, Xuedong

    2011-10-27

    Studies have suggested that octanitrocubane (ONC) is one of the most powerful non-nuclear high energy density material (HEDM) currently known. 2,4,6,8-Tetranitro-1,3,5,7-tetraazacubane (TNTAC) studied in this work may also be a novel HEDM due to its high nitrogen content and crystal density. Density functional theory and molecular mechanics methods have been employed to study the crystal structure, IR spectrum, electronic structure, thermodynamic properties, gas-phase and condensed-phase heat of formation, detonation performance, and pyrolysis mechanism of TNTAC. The TNTAC has a predicted density of about 2.12 g/cm(3), and its detonation velocity (10.42 km/s) and detonation pressure (52.82 GPa) are higher than that of ONC. The crystalline packing is P2(1)2(1)2(1), and the corresponding cell parameters are Z = 4, a = 8.87 Å, b = 8.87 Å, and c = 11.47 Å. Both the density of states of the predicted crystal and the bond dissociation energy of the molecule in gas phase show that the cage C-N bond is the trigger bond during thermolysis. The activation energy of the pyrolysis initiation reaction obtained from the B3LYP/6-311++G(2df,2p) level is 125.98 kJ/mol, which indicates that TNTAC meets the thermal stability request as an exploitable HEDM. PMID:21919441

  13. [Synthesis of stable solvates of monosodium 2-[R*s,9S*)-(4-methoxy-6,7,8, 9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)sulfinyl]-1H-benzimidazole].

    PubMed

    Yamada, S; Goto, T; Yuasa, S; Yamaguchi, T; Kogi, K

    1996-08-01

    Monosodium 2-[(R*s,9S*)-(4-methoxy-6,7,8, 9-tetrahydro-5H-cyclohepta-[b]pyridin-9-yl)sulfinyl]-1H-benzimidazole (3A), a novel antiulcer agent previously reported by us, was found to be easily decomposed in weakly acidic solutions. In order to improve the stability of the parent compound, 3A, the preparation of 1-substituted benzimidazoles (4A) was attempted. However, the inhibitory effect of 4A against gastric acid secretion was less potent than that of 3A. Then 3A was solvated by EtOH or H2O to afford 5A or 6A, respectively. On the other hand, an another diastereoisomer, (R*s,9R*)-3B, was not solvated by EtOH or H2O under the same conditions. The thus obtained solvates (5A, 6A) are much more stable than that of 3A. The antiulcer activities of 5A and 6A were found to be similar to that of the parent compound (3A). Consequently, 6A was selected as an antiulcer agent for the development.

  14. Ionospheric anomalies related to the (M = 7.3), August 27, 2012, Puerto earthquake, (M = 6.8), August 30, 2012 Jan Mayen Island earthquake, and (M = 7.6), August 31, 2012, Philippines earthquake: two-dimensional principal component analysis.

    PubMed

    Lin, Jyh-Woei

    2013-01-01

    Two-dimensional principal component analysis (2DPCA) and principal component analysis (PCA) are used to examine the ionospheric total electron content (TEC) data during the time period from 00:00 on August 21 to 12: 45 on August 31 (UT), which are 10 days before the M = 7.6 Philippines earthquake at 12:47:34 on August 31, 2012 (UT) with the depth at 34.9 km. From the results by using 2DPCA, a TEC precursor of Philippines earthquake is found during the time period from 4:25 to 4:40 on August 28, 2012 (UT) with the duration time of at least 15 minutes. Another earthquake-related TEC anomaly is detectable for the time period from 04:35 to 04:40 on August 27, 2012 (UT) with the duration time of at least 5 minutes during the Puerto earthquake at 04: 37:20 on August 27, 2012 (UT) (M(w) = 7.3) with the depth at 20.3 km. The precursor of the Puerto earthquake is not detectable. TEC anomaly is not to be found related to the Jan Mayen Island earthquake (M w = 6.8) at 13:43:24 on August 30, 2012 (UT). These earthquake-related TEC anomalies are detectable by using 2DPCA rather than PCA. They are localized nearby the epicenters of the Philippines and Puerto earthquakes.

  15. [5-(2-Fur­yl)-6-nitro-1,2,3,5,6,7-hexa­hydro­imidazo[1,2-a]pyridin-8-yl](phen­yl)methanone

    PubMed Central

    Yaqub, Muhammad; Shafiq, Zahid; Qureshi, Ashfaq M.; Najam-ul-Haq, Muhammad

    2009-01-01

    In the title compound, C18H17N3O4, the furyl and phenyl rings are inclined at almost right angles [85.77 (7) and 63.25 (7)°, respectively] to the central imidazo[1,2-a]pyridinyl unit. The structure displays both inter- and intra­molecular N—H⋯O hydrogen bonding. PMID:21577676

  16. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  17. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  18. 7 CFR 774.6 - Eligibility requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false Eligibility requirements. 774.6 Section 774.6 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS EMERGENCY LOAN FOR SEED PRODUCERS PROGRAM § 774.6 Eligibility requirements....

  19. 7 CFR 1957.6 - Appeal reviews.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DC, under the FmHA or its successor agency under Public Law 103-354 Appeal Procedures, 7 CFR part... 7 Agriculture 14 2014-01-01 2014-01-01 false Appeal reviews. 1957.6 Section 1957.6 Agriculture... REGULATIONS (CONTINUED) ASSET SALES Rural Housing Asset Sales § 1957.6 Appeal reviews. The Master...

  20. 7 CFR 1957.6 - Appeal reviews.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DC, under the FmHA or its successor agency under Public Law 103-354 Appeal Procedures, 7 CFR part... 7 Agriculture 14 2011-01-01 2011-01-01 false Appeal reviews. 1957.6 Section 1957.6 Agriculture... REGULATIONS (CONTINUED) ASSET SALES Rural Housing Asset Sales § 1957.6 Appeal reviews. The Master...