Science.gov

Sample records for 6-7 month period

  1. New periodic 6.7 GHz class II methanol maser associated with G358.460-0.391

    NASA Astrophysics Data System (ADS)

    Maswanganye, J. P.; Gaylard, M. J.; Goedhart, S.; Walt, D. J. van der; Booth, R. S.

    2015-01-01

    Eight new class II methanol masers selected from the 6.7 GHz Methanol Multibeam survey catalogues I and II were monitored at 6.7 GHz with the 26 m Hartebeesthoek Radio Astronomy Observatory radio telescope for three years and seven months, from 2011 February to 2014 September. The sources were also observed at 12.2 GHz and two were sufficiently bright to permit monitoring. One of the eight sources, namely G358.460-0.391, was found to show periodic variations at 6.7 GHz. The period was determined and tested for significance using the Lomb-Scargle, epoch-folding and Jurkevich methods, and by fitting a simple analytic function. The best estimate for the period of the 6.7 GHz class II methanol maser line associated with G358.460-0.391 is 220.0 ± 0.2 d.

  2. Kinematics of the standardbred trotter measured at 6, 7, 8 and 9 m/s on a treadmill, before and after 5 months of prerace training.

    PubMed

    van Weeren, P R; van den Bogert, A J; Back, W; Bruin, G; Barneveld, A

    1993-01-01

    A kinematic study was performed on a group of 8 Standardbred stallions. Recordings were done using a modified CODA-3 optoelectronic kinematic analysis system with the horses running on a treadmill at speeds of 6, 7, 8, or 9 m/s. Linear and temporal gait characteristics, joint angle diagrams and the trajectories of the hoof in a plane perpendicular to the direction of movement were studied. Two consecutive recording sessions were held at an age of 21-23 months, and a third was held 5 months later after an intensive training period. Joint angle diagrams appeared to show a similar pattern for all horses though certain individual characteristics could be identified. Only a few kinematic parameters appeared to have significantly changed after the 5-month training period (p < 0.05). The hoof trajectories showed marked and consistent differences between front and hind hooves, but the most striking feature was the very individual character of the patterns exhibited, leading to the assumption that these patterns could possibly be used as the 'fingerprint' of the horse. PMID:8470459

  3. 39 CFR 3050.28 - Monthly and pay period reports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Monthly and pay period reports. 3050.28 Section 3050.28 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PERIODIC REPORTING § 3050.28 Monthly and... electronic form (pay period); (e) On-roll and Paid Employee Statistics (ORPES) (pay period); and (f)...

  4. 39 CFR 3050.28 - Monthly and pay period reports.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Monthly and pay period reports. 3050.28 Section 3050.28 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PERIODIC REPORTING § 3050.28 Monthly and... electronic form (pay period); (e) On-roll and Paid Employee Statistics (ORPES) (pay period); and (f)...

  5. 39 CFR 3050.28 - Monthly and pay period reports.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Monthly and pay period reports. 3050.28 Section 3050.28 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PERIODIC REPORTING § 3050.28 Monthly and... electronic form (pay period); (e) On-roll and Paid Employee Statistics (ORPES) (pay period); and (f)...

  6. 39 CFR 3050.28 - Monthly and pay period reports.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Monthly and pay period reports. 3050.28 Section 3050.28 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PERIODIC REPORTING § 3050.28 Monthly and... Service Active Employee Statistical Summary (HAT report) (pay period)....

  7. Implementation of an Aerosol-Cloud Microphysics-Radiation Coupling into the NASA Unified WRF: Simulation Results for the 6-7 August 2006 AMMA Special Observing Period

    NASA Technical Reports Server (NTRS)

    Shi, J. J.; Matsui, T.; Tao, W.-K.; Tan, Q.; Peters-Lidard, C.; Chin, M.; Pickering, K.; Guy, N.; Lang, S.; Kemp, E. M.

    2014-01-01

    Aerosols affect the Earth's radiation balance directly and cloud microphysical processes indirectly via the activation of cloud condensation and ice nuclei. These two effects have often been considered separately and independently, hence the need to assess their combined impact given the differing nature of their effects on convective clouds. To study both effects, an aerosol-microphysics-radiation coupling, including Goddard microphysics and radiation schemes, was implemented into the NASA Unified Weather Research and Forecasting model (NU-WRF). Fully coupled NU-WRF simulations were conducted for a mesoscale convective system (MCS) that passed through the Niamey, Niger area on 6-7 August 2006 during an African Monsoon Multidisciplinary Analysis (AMMA) special observing period. The results suggest that rainfall is reduced when aerosol indirect effects are included, regardless of the aerosol direct effect. Daily mean radiation heating profiles in the area traversed by the MCS showed the aerosol (mainly mineral dust) direct effect had the largest impact near cloud tops just above 200 hectopascals where short-wave heating increased by about 0.8 Kelvin per day; the weakest long-wave cooling was at around 250 hectopascals. It was also found that more condensation and ice nuclei as a result of higher aerosol/dust concentrations led to increased amounts of all cloud hydrometeors because of the microphysical indirect effect, and the radiation direct effect acts to reduce precipitating cloud particles (rain, snow and graupel) in the middle and lower cloud layers while increasing the non-precipitating particles (ice) in the cirrus anvil. However, when the aerosol direct effect was activated, regardless of the indirect effect, the onset of MCS precipitation was delayed about 2 hours, in conjunction with the delay in the activation of cloud condensation and ice nuclei. Overall, for this particular environment, model set-up and physics configuration, the effect of aerosol

  8. 17 CFR 210.3-06 - Financial statements covering a period of nine to twelve months.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... a period of nine to twelve months. 210.3-06 Section 210.3-06 Commodity and Securities Exchanges... General Instructions As to Financial Statements § 210.3-06 Financial statements covering a period of nine... statements covering a period of nine to 12 months shall satisfy a filing requirement of financial...

  9. 17 CFR 210.3-06 - Financial statements covering a period of nine to twelve months.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... a period of nine to twelve months. 210.3-06 Section 210.3-06 Commodity and Securities Exchanges... General Instructions As to Financial Statements § 210.3-06 Financial statements covering a period of nine... statements covering a period of nine to 12 months shall satisfy a filing requirement of financial...

  10. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 6 2014-04-01 2014-04-01 false Returns for periods of less than 12 months. 1.443-1 Section 1.443-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Accounting Periods § 1.443-1 Returns for periods of less than 12 months. (a) Returns for...

  11. 34 CFR 75.250 - Project period can be up to 60 months.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Project period can be up to 60 months. 75.250 Section... Are Made Approval of Multi-Year Projects § 75.250 Project period can be up to 60 months. The Secretary may approve a project period of up to 60 months. (Authority: 20 U.S.C. 1221e-3 and 3474)...

  12. 34 CFR 75.250 - Project period can be up to 60 months.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Project period can be up to 60 months. 75.250 Section... Are Made Approval of Multi-Year Projects § 75.250 Project period can be up to 60 months. The Secretary may approve a project period of up to 60 months. (Authority: 20 U.S.C. 1221e-3 and 3474)...

  13. 34 CFR 75.250 - Project period can be up to 60 months.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Project period can be up to 60 months. 75.250 Section... Are Made Approval of Multi-Year Projects § 75.250 Project period can be up to 60 months. The Secretary may approve a project period of up to 60 months. (Authority: 20 U.S.C. 1221e-3 and 3474)...

  14. 34 CFR 75.250 - Project period can be up to 60 months.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Project period can be up to 60 months. 75.250 Section... Are Made Approval of Multi-Year Projects § 75.250 Project period can be up to 60 months. The Secretary may approve a project period of up to 60 months. (Authority: 20 U.S.C. 1221e-3 and 3474)...

  15. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 6 2013-04-01 2013-04-01 false Returns for periods of less than 12 months. 1.443-1 Section 1.443-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... period ($18,836×1/12) 1,570 Example 3. The Y Corporation makes a re- turn for the six-month period...

  16. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 6 2012-04-01 2012-04-01 false Returns for periods of less than 12 months. 1.443-1 Section 1.443-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... period ($18,836×1/12) 1,570 Example 3. The Y Corporation makes a re- turn for the six-month period...

  17. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false Returns for periods of less than 12 months. 1.443-1 Section 1.443-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... period ($18,836×1/12) 1,570 Example 3. The Y Corporation makes a re- turn for the six-month period...

  18. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 6 2011-04-01 2011-04-01 false Returns for periods of less than 12 months. 1.443-1 Section 1.443-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... period ($18,836×1/12) 1,570 Example 3. The Y Corporation makes a re- turn for the six-month period...

  19. Spurious One-Month and One-Year Periods in Visual Observations of Variable Stars

    NASA Astrophysics Data System (ADS)

    Percy, J. R.

    2015-12-01

    Visual observations of variable stars, when time-series analyzed with some algorithms such as DC-DFT in vstar, show spurious periods at or close to one synodic month (29.5306 days), and also at about a year, with an amplitude of typically a few hundredths of a magnitude. The one-year periods have been attributed to the Ceraski effect, which was believed to be a physiological effect of the visual observing process. This paper reports on time-series analysis, using DC-DFT in vstar, of visual observations (and in some cases, V observations) of a large number of stars in the AAVSO International Database, initially to investigate the one-month periods. The results suggest that both the one-month and one-year periods are actually due to aliasing of the stars' very low-frequency variations, though they do not rule out very low-amplitude signals (typically 0.01 to 0.02 magnitude) which may be due to a different process, such as a physiological one. Most or all of these aliasing effects may be avoided by using a different algorithm, which takes explicit account of the window function of the data, and/or by being fully aware of the possible presence of and aliasing by very low-frequency variations.

  20. Oscillations in D-region absorption at periods of one to two months

    NASA Technical Reports Server (NTRS)

    Stanford, J. L.; Saksena, R. C.

    1989-01-01

    One to two month oscillations in D-region absorption are found in seven years of daily f-min data from low latitude stations at Singapore (1 deg N, 104 deg E) and Rarotonga (21 deg S, 160 deg W). Coherency (cross-spectral) analyses reveal that solar flux variations account for much of the f-min variance at these periods. Over the range of periods from 10 to 200 days, statistically significant linear correlation is found between the f-min time series and contemporaneous 10.7 cm solar flux measurements at periods of 16-19 days, the 26-29 day solar rotation band, and a broad band covering 43-80 day periods.

  1. Phonetogram changes for trained singers over a nine-month period of vocal training.

    PubMed

    LeBorgne, Wendy DeLeo; Weinrich, Barbara D

    2002-03-01

    Professional vocalists encounter demands requiring voluntary control of phonation, while utilizing a considerable range of frequency and intensity. These quantifiable acoustic events can be measured and represented in a phonetogram. Previous research has compared the phonetograms of trained and untrained voices and found significant differences between these groups. This study was designed to assess the effects of vocal training for singers over a period of nine months. Phonetogram contour changes were examined, with the primary focus on expansion of frequency range and/or intensity control. Twenty-one first-year, master's level, vocal music students, who were engaged in an intensive vocal performance curriculum, participated in this study. Following nine months of vocal training, significant differences were revealed in the subjects' mean frequency range and minimum vocal intensity across frequency levels. There was no significant difference for the mean maximum vocal intensity across frequency levels following vocal training. PMID:12002885

  2. Time-space Variability of Weekly to Monthly Period Equatorial Waves in the Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Durland, T.; Farrar, J. T.

    2015-12-01

    Data from satellite altimetry are used to characterize wavelike variability in the tropical Pacific Ocean at periods of days to two months. This period band is of interest because the space-time scales of oceanic equatorial waves at these frequencies have historically made adequate observation of the variability difficult. These waves have zonal scales that are very large (exceeding 3000 km) and meridional scales that are relatively short (~100 km), making in situ measurements difficult, and the short temporal scales pose challenges for observation with satellite altimeters because the wave periods are short compared to orbit repeat periods. As a result, there has been relatively little progress since the early 1980s in characterizing and understanding these equatorial inertia-gravity and mixed Rossby-gravity waves. In this analysis, we seek to exploit the long zonal length scales of these high-frequency equatorial waves in an analysis of satellite scatterometer and altimeter data to shed new light on the properties and dynamics of these waves. At periods of 2-14 days, there is clear evidence for the presence of several basin-scale equatorial wave modes, including mixed Rossby-gravity waves and inertia-gravity waves associated with baroclinic modes one and two. Here, we focus on equatorial Kelvin waves and mixed Rossby-gravity waves forced in the western Pacific, and examine their variability in time and space and their relation to wind.

  3. 77 FR 33749 - Notice of a Noncompetitive Supplement and a 7-Month Extension of the Period of Support for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... 7-Month Extension of the Period of Support for the Frontier Extended Stay Clinic (FESC) Cooperative... a 7-Month Extension of the Period of Support for the Frontier Extended Stay Clinic (FESC... and Services Administration (HRSA) will be issuing a non-competitive supplement and a...

  4. 22 CFR 19.6-7 - Decision.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-7 Decision. (a) When a response has not been... the court order or divorce decree, and the record contains support for the objection, PER/ER/RET will... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Decision. 19.6-7 Section 19.6-7...

  5. 22 CFR 19.6-7 - Decision.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-7 Decision. (a) When a response has not been... the court order or divorce decree, and the record contains support for the objection, PER/ER/RET will... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Decision. 19.6-7 Section 19.6-7...

  6. 22 CFR 19.6-7 - Decision.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-7 Decision. (a) When a response has not been... the court order or divorce decree, and the record contains support for the objection, PER/ER/RET will... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Decision. 19.6-7 Section 19.6-7...

  7. 22 CFR 19.6-7 - Decision.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-7 Decision. (a) When a response has not been... the court order or divorce decree, and the record contains support for the objection, PER/ER/RET will... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Decision. 19.6-7 Section 19.6-7...

  8. 39 CFR 6.7 - Notation voting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Notation voting. 6.7 Section 6.7 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE MEETINGS (ARTICLE VI) § 6.7 Notation voting. (a) General. Notation voting consists of the circulation of written memoranda...

  9. 39 CFR 6.7 - Notation voting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Notation voting. 6.7 Section 6.7 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE MEETINGS (ARTICLE VI) § 6.7 Notation voting. (a) General. Notation voting consists of the circulation of written memoranda...

  10. 39 CFR 6.7 - Notation voting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Notation voting. 6.7 Section 6.7 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE MEETINGS (ARTICLE VI) § 6.7 Notation voting. (a) General. Notation voting consists of the circulation of written memoranda...

  11. 22 CFR 19.6-7 - Decision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Decision. 19.6-7 Section 19.6-7 Foreign... FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-7 Decision. (a) When a response has not been..., PER/ER/RET will advise both parties of the basis for its decision and the alternative action, if...

  12. Prevalence of antiseptic resistance genes increases in staphylococcal isolates from orthokeratology lens wearers over initial six-month period of use.

    PubMed

    Guang-Sen, Shi; Boost, Maureen; Cho, Pauline

    2016-06-01

    The purpose of this study was to investigate the prevalence of antiseptic-resistance (QAC) genes in staphylococci colonizing periorbital tissues and accessories of orthokeratology (ortho-k) lens wearers over a 6-month period and determine the effect of their presence on minimum inhibitory (MIC) and bactericidal concentrations (MBC) of disinfectants and log reduction of multipurpose contact lens solutions (MPS). Staphylococci were isolated from periorbital tissues and accessories of patients before commencing ortho-k therapy and at two subsequent visits. Presence of QAC genes in 116 S. aureus and 67 CNS isolates was determined by PCR and association with period of ortho-k use determined. MICs and MBCs of staphylococci gene-positive were compared with gene-negative strains and the effectiveness of four MPS for rigid contact lenses investigated. S. aureus carriage rates in the conjunctiva decreased significantly from 41.2 % (baseline) to 11.8 % (3-months), and 13.3 % (6-months) (p trend 0.03), while CNS increased from 58.8 %(baseline) to 94.1 % (3-months), and 93.3 % (6-months) (p trend 0.02). Prevalence of qacA/B increased considerably over time (S. aureus: 4.4 % to 15.4 %, CNS: 6.7 % to 25 %), but frequency of smr was relatively stable. Only five CNS isolates harboured qacH. MICs and MBCs of gene-positive isolates were significantly increased and three MPS did not achieve a 3-log reduction of many QAC-positive strains. Ortho-k lens wear contributed to changes of staphylococcal carriage rates in the conjunctival sac. Use of MPS containing quaternary ammonium compounds may select for the carriage of organisms harbouring QAC genes, as the low concentration of disinfecting agents is not adequate for killing gene-positive strains. PMID:26993290

  13. Isolation and Characterization of Glycopeptide-Resistant Enterococci from Hospitalized Patients over a 30-Month Period

    PubMed Central

    Nelson, R. R. S.; McGregor, K. F.; Brown, A. R.; Amyes, S. G. B.; Young, H.-K.

    2000-01-01

    In February 1996, a Hospital Infection Control Practices Advisory Committee-style screening program was commenced to isolate and subsequently characterize glycopeptide-resistant enterococci (GRE) from patients at a hospital trust in Glasgow, Scotland. Over the next 30 months, GRE were isolated from 154 patients. GRE were isolated from patients in traditionally high-risk areas such as the renal unit and intensive care unit and also in areas considered to be lower risk, including medical wards and associated long-stay geriatric hospitals. The majority (90%) of isolates were Enterococcus faecium vanB. The remaining isolates consisted of seven E. faecalis (vanA), three E. gallinarum (vanC), and a further six E. faecium (five vanA, one both vanA and vanB) isolates. Analysis of SmaI-digested DNA by pulsed-field gel electrophoresis revealed that 34 of 40 (85%) VanB E. faecium isolates were identical or closely related, while 11 of 13 (85%) VanA GRE were distinct. High-level aminoglycoside resistance was seen in less than 8% of isolates. VanB E. faecium isolates were almost uniformly resistant to ampicillin and tetracycline. In this study, GRE have been isolated over a prolonged period from a broad range of patients. Glycopeptide resistance within the study hospital trust appeared to be mainly due to the clonal dissemination of a single strain of E. faecium VanB. PMID:10834962

  14. Fusing Paleo-Data and Models: A Monthly Reanalysis for the Period 1600 to 2000

    NASA Astrophysics Data System (ADS)

    Franke, Jörg; Brönnimann, Stefan; Bhend, Jonas

    2016-04-01

    One of the backbones of numerical weather prediction is the assimilation of all available observations into models to achieve initial conditions close to reality. The assimilation idea also revolutionized climate research with reanalysis becoming the most important data set for studying the last century. Recently, paleo-climatologist began developing new methodologies with the intention to assimilate sparse and temporally averaged proxy information instead of satellite data and instrumental observations. Here, we present the first monthly resolved paleo-reanalysis covering the period 1600 to 2005. Early instrumental temperature and surface pressure observations, temperature indices derived from historical documents and temperature and moisture sensitive tree-ring proxies were assimilated into an ensemble of atmospheric general circulation model using a Kalman-filtering technique. The resulting paleo-reanalysis combines the advantage of traditional reconstruction methods of being as close a possible to observations with the advantage of climate models of being physically consistent and having 3-dimensional information about the state of the atmosphere through time and for various variables. Moreover, it makes no stationarity assumptions, has temporally constant variability and offers error estimates. Using direct and indirect climate observation, climate forcings and models together, we will present the probably best supported northern hemisphere temperature evolution of the past 400 years, as well as spatial imprints of the 1790ies droughts and the 1815 Tambora eruption.

  15. 49 CFR 385.333 - What happens at the end of the 18-month safety monitoring period?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... by the end of the 18-month monitoring period through no fault of the motor carrier, the carrier will... (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER... FMCSA will evaluate the motor carrier on the same basis as any other carrier. (b) If a new entrant...

  16. 49 CFR 385.333 - What happens at the end of the 18-month safety monitoring period?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... by the end of the 18-month monitoring period through no fault of the motor carrier, the carrier will... (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER... FMCSA will evaluate the motor carrier on the same basis as any other carrier. (b) If a new entrant...

  17. 49 CFR 385.333 - What happens at the end of the 18-month safety monitoring period?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... by the end of the 18-month monitoring period through no fault of the motor carrier, the carrier will... (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER... FMCSA will evaluate the motor carrier on the same basis as any other carrier. (b) If a new entrant...

  18. 49 CFR 385.333 - What happens at the end of the 18-month safety monitoring period?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... by the end of the 18-month monitoring period through no fault of the motor carrier, the carrier will... (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER... FMCSA will evaluate the motor carrier on the same basis as any other carrier. (b) If a new entrant...

  19. 49 CFR 385.333 - What happens at the end of the 18-month safety monitoring period?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... by the end of the 18-month monitoring period through no fault of the motor carrier, the carrier will... (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER... FMCSA will evaluate the motor carrier on the same basis as any other carrier. (b) If a new entrant...

  20. Shopping Behaviors of Low-income Families during a 1-Month Period of Time

    ERIC Educational Resources Information Center

    Darko, Janice; Eggett, Dennis L.; Richards, Rickelle

    2013-01-01

    Objective: To explore food shopping behaviors among low-income families over the course of the month. Design: Two researchers conducted 13 90-minute focus groups. Setting: Two community organizations serving low-income populations and a university campus. Participants: Low-income adults (n = 72) who were the primary household food shoppers and who…

  1. A prospective study of atopic dermatitis managed without topical corticosteroids for a 6-month period

    PubMed Central

    Fukaya, Mototsugu; Sato, Kenji; Yamada, Takahiro; Sato, Mitsuko; Fujisawa, Shigeki; Minaguchi, Satoko; Kimata, Hajime; Dozono, Haruhiko

    2016-01-01

    Topical corticosteroids (TCS) are regarded as the mainstay treatment for atopic dermatitis (AD). As AD has a tendency to heal naturally, the long-term efficacy of TCS in AD management should be compared with the outcomes seen in patients with AD not using TCS. However, there are few long-term studies that consider patients with AD not using TCS. We designed a prospective multicenter cohort study to assess the clinical outcomes in patients with AD who did not use TCS for 6 months and then compared our results with an earlier study by Furue et al which considered AD patients using TCS over 6 months. Our patients’ clinical improvement was comparable with the patients described in Furue’s research. In light of this, it is reasonable for physicians to manage AD patients who decline TCS, as the expected long-term prognosis is similar whether they use TCS or not. PMID:27445501

  2. Progress report for the first twenty-one months of the contract period

    SciTech Connect

    Not Available

    1980-01-01

    During the period of July 1, 1978, through March 31, 1980 in-depth research of the legal and institutional obstacles and incentives to the development of small scale hydroelectric power in all of the nineteen northeastern states was performed. Research into economic issues associated with the development of small scale hydroelectric power was undertaken by the project economist. Special research activities have been undertaken with respect to the federal dam safety programs, the National Pollution Discharge Elimination System requirements of the Federal Clean Water Act and the implications of those requirements to small scale hydroelectric power, riparian law on lake and reservoir fluctuation in the State of Maine, and the implications of Title II and IV of the Public Utility Regulatory Policies Act of 1978 to the development of small scale hydroelectric power. The results of these studies are reported. (LCL)

  3. Six-month low level chlorine dioxide gas inhalation toxicity study with two-week recovery period in rats

    PubMed Central

    2012-01-01

    Background Chlorine dioxide (CD) gas has a potent antimicrobial activity at extremely low concentration and may serve as a new tool for infection control occupationally as well as publicly. However, it remains unknown whether the chronic exposure of CD gas concentration effective against microbes is safe. Therefore, long-term, low concentration CD gas inhalation toxicity was studied in rats as a six-month continuous whole-body exposure followed by a two-week recovery period, so as to prove that the CD gas exposed up to 0.1 ppm (volume ratio) is judged as safe on the basis of a battery of toxicological examinations. Methods CD gas at 0.05 ppm or 0.1 ppm for 24 hours/day and 7 days/week was exposed to rats for 6 months under an unrestrained condition with free access to chow and water in a chamber so as to simulate the ordinary lifestyle in human. The control animals were exposed to air only. During the study period, the body weight as well as the food and water consumptions were recorded. After the 6-month exposure and the 2-week recovery period, animals were sacrificed and a battery of toxicological examinations, including biochemistry, hematology, necropsy, organ weights and histopathology, were performed. Results Well regulated levels of CD gas were exposed throughout the chamber over the entire study period. No CD gas-related toxicity sign was observed during the whole study period. No significant difference was observed in body weight gain, food and water consumptions, and relative organ weight. In biochemistry and hematology examinations, changes did not appear to be related to CD gas toxicity. In necropsy and histopathology, no CD gas-related toxicity was observed even in expected target respiratory organs. Conclusions CD gas up to 0.1 ppm, exceeding the level effective against microbes, exposed to whole body in rats continuously for six months was not toxic, under a condition simulating the conventional lifestyle in human. PMID:22348507

  4. Normal probabilities for Cape Kennedy wind components: Monthly reference periods for all flight azimuths. Altitudes 0 to 70 kilometers

    NASA Technical Reports Server (NTRS)

    Falls, L. W.

    1973-01-01

    This document replaces Cape Kennedy empirical wind component statistics which are presently being used for aerospace engineering applications that require component wind probabilities for various flight azimuths and selected altitudes. The normal (Gaussian) distribution is presented as an adequate statistical model to represent component winds at Cape Kennedy. Head-, tail-, and crosswind components are tabulated for all flight azimuths for altitudes from 0 to 70 km by monthly reference periods. Wind components are given for 11 selected percentiles ranging from 0.135 percent to 99,865 percent for each month. Results of statistical goodness-of-fit tests are presented to verify the use of the Gaussian distribution as an adequate model to represent component winds at Cape Kennedy, Florida.

  5. Normal probabilities for Vandenberg AFB wind components - monthly reference periods for all flight azimuths, 0- to 70-km altitudes

    NASA Technical Reports Server (NTRS)

    Falls, L. W.

    1975-01-01

    Vandenberg Air Force Base (AFB), California, wind component statistics are presented to be used for aerospace engineering applications that require component wind probabilities for various flight azimuths and selected altitudes. The normal (Gaussian) distribution is presented as a statistical model to represent component winds at Vandenberg AFB. Head tail, and crosswind components are tabulated for all flight azimuths for altitudes from 0 to 70 km by monthly reference periods. Wind components are given for 11 selected percentiles ranging from 0.135 percent to 99.865 percent for each month. The results of statistical goodness-of-fit tests are presented to verify the use of the Gaussian distribution as an adequate model to represent component winds at Vandenberg AFB.

  6. Prevalence, incidence and course of lower extremity injuries in runners during a 12-month follow-up period.

    PubMed

    van Poppel, D; Scholten-Peeters, G G M; van Middelkoop, M; Verhagen, A P

    2014-12-01

    To describe the incidence, 12-month prevalence, and course of lower extremity injuries that occurred during and after the Amgen Singelloop Breda in 2009. The design was based on a prospective cohort study with a population-based setting. In total, 3605 registered runners received a web-based baseline questionnaire of which 713 participants completed and returned it. Information about previous injuries, training programs, and demographic data were gathered at baseline. Site and intensity of running injuries and occurrence of new injuries were obtained from five post-race questionnaires. The main outcome measurement was lower extremity injury. The incidence of running injuries during the Amgen Singelloop Breda itself was 7.8%; most of these injuries occurred in the calf muscle, thigh, and knee joint. Three-month incidence of injuries during follow-up varied between 13.5% and 16.3%. During the 12-month follow-up period, 277 new running injuries were reported. Runners who ran more than 10 km are more susceptible to injury in comparison with runners who ran short distances (10 km or less). In total, 69.1% of running injuries resolves within 10 days. Running injuries are very common among recreational runners. Injuries mostly occur in the knee, thigh, and calf muscle. PMID:23957385

  7. RDamage 6, 7, 8 & 9 Cassettes

    SciTech Connect

    Griego, Jeffrey R; Kaul, Ann

    2012-06-08

    The RDamage series of ten experiments is part of a long-term collaboration with RFNC/VNIIEF in pulsed power technology. These experiments use a cylindrical configuration to study spallation damage, which allows for a natural recollection of the damaged material under proper driving conditions and post-shot collection of the damaged target material for subsequent metallographic analysis. Dynamic insitu experimental velocimetry diagnostics are also employed. LANL is responsible for the design of the experimental load and velocimetry system. VNIIEF is responsible for the design and construction of the driving explosive magnetic generator. In the RDamage-0, -1 and -2 experiments, data was collected about failure initiation of a well-characterized material (aluminum) in a cylindrical geometry. The RDamage-3, -4 and -5 experiments produced data on the behavior of material recollected after damage from pressures in the damage initiation regime. Data on the behavior of material recollected after complete failure was collected in the RDamage-6, -7, -8 and -9 experiments. This presentation shows the evolution of the load assembly through the experimental series.

  8. Improving the uptake and comprehensiveness of bedside cognitive testing amongst liaison psychiatrists over an eight-month period.

    PubMed

    McCormack, Ruaidhri

    2016-01-01

    The aim of this quality improvement (QI) project was to improve the uptake and comprehensiveness of bedside cognitive testing amongst liaison psychiatrists over an eight month period. The baseline measurement involved an audit of the practice of the neuropsychiatry liaison team over six months at the 840 bed St Thomas's Hospital in London, UK. Of 35 referrals, 21 patients were able, and suitable, for cognitive testing based on the referral data and clinical interview. Fourteen (66.6%) of these patients had an Addenbrooke's Cognitive Examination (ACE), while 5 (23.8%) had frontal testing. The frontal tests performed were variable and inconsistent. Two Plan-Do-Study-Act (PDSA) cycles were then conducted. Clear guidance was issued to the team on the use of the ACE or Montreal Cognitive Assessment (MoCA) in suitable patients, and how these can be supplemented by frontal testing. Given the inconsistency in the types and combination of frontal tests being conducted at baseline, a frontal lobe test sheet containing established tests was developed and implemented. In PDSA cycle 1, 100% (n=10) of able and suitable referrals had an ACE or MoCA while 100% had frontal testing (80% of these using the dedicated test sheet). In PDSA cycle 2, improvements were broadly maintained with 85.7% (n=6) of referrals having an ACE/MoCA and 85.7% having frontal testing (83.3% of these using the dedicated frontal test sheet). In conclusion, our team improved the uptake and comprehensiveness of bedside cognitive testing by changing existing practice with clear protocols regarding the use of the ACE/MoCA and the implementation of a frontal test sheet. PMID:27096088

  9. Common antimicrobial resistance phenotypes and genotypes of fecal Escherichia coli isolates from a single family over a 6-month period.

    PubMed

    Al-Dweik, Manar R; Shehabi, Asem A

    2009-06-01

    This study investigated the antimicrobial resistance phenotypes and genotypes among fecal Escherichia coli isolates from the members of a single Jordanian family over a 6-month period. A total of 55 (51%) E. coli isolates were resistant to >2, and 21 (19%) to >3 of the 14 tested antimicrobial agents, respectively. The highest resistance rates were observed to tetracycline (42%), followed by coamoxyclav and cotrimoxazole (32%), gentamicin (31%), and nalidixic acid (27%). Sixteen out of 21 (76%) multiresistant E. coli isolates (resistant to >3 drugs) transferred most of their resistance markers in vitro to E. coli K12. Five out of the six family members were colonized with E. coli carrying one or two of the two common plasmid sizes (54.3 and 13.2 kb). Ten of these isolates (48%) were positive for class 1 integron genes and harbored four tet (A) and five tet (B) genes, respectively, but all were negative for tet (39). The genetic diversity of E. coli isolates using randomly amplified polymorphic DNA-PCR demonstrated 13 major clusters of genotype groups, and most of the isolates (63%) belonged to one genotype group. This study indicates that all six family members are colonized with fecal E. coli isolates exhibiting a common number of antimicrobial resistance phenotypes and at least one prevalent genotype. PMID:19432518

  10. 43 CFR 6.7 - Domestic patent protection.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Domestic patent protection. 6.7 Section 6.7 Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Inventions by Employees § 6.7 Domestic patent protection. (a) The Solicitor, upon determining that an invention coming...

  11. 43 CFR 6.7 - Domestic patent protection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Domestic patent protection. 6.7 Section 6.7 Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Inventions by Employees § 6.7 Domestic patent protection. (a) The Solicitor, upon determining that an invention...

  12. 43 CFR 6.7 - Domestic patent protection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Domestic patent protection. 6.7 Section 6.7 Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Inventions by Employees § 6.7 Domestic patent protection. (a) The Solicitor, upon determining that an invention...

  13. 43 CFR 6.7 - Domestic patent protection.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Domestic patent protection. 6.7 Section 6.7 Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Inventions by Employees § 6.7 Domestic patent protection. (a) The Solicitor, upon determining that an invention...

  14. 43 CFR 6.7 - Domestic patent protection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Domestic patent protection. 6.7 Section 6.7 Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Inventions by Employees § 6.7 Domestic patent protection. (a) The Solicitor, upon determining that an invention...

  15. Inhalation of tobacco and marijuana in dog over a period of 30 months: effect on body weight, food intake and organ weight.

    PubMed

    Huy, N D; Roy, P E

    1976-03-01

    The measures of body weight and food intake in marijuana or tobacco smoking dogs and a non-smoking control group show no significant change after 27 months of inhalation; except a slowing of weight gain during 9 months, in spite of increased food consumption at 3 months. During this period, the tobacco smokers ate much less and at the 9 th month only a significant slowing in weight gain was noted. At the end of the experiment, the organ weight/total weight ratio of these 3 groupes of dogs presented no significant difference. PMID:935636

  16. Nature and Determinants of the Course of Chronic Low Back Pain Over a 12-Month Period: A Cluster Analysis

    PubMed Central

    Maher, Christopher G.; Latimer, Jane; McAuley, James H.; Hodges, Paul W.; Rogers, W. Todd

    2014-01-01

    Background It has been suggested that low back pain (LBP) is a condition with an unpredictable pattern of exacerbation, remission, and recurrence. However, there is an incomplete understanding of the course of LBP and the determinants of the course. Objective The purposes of this study were: (1) to identify clusters of LBP patients with similar fluctuating pain patterns over time and (2) to investigate whether demographic and clinical characteristics can distinguish these clusters. Design This study was a secondary analysis of data extracted from a randomized controlled trial. Methods Pain scores were collected from 155 participants with chronic nonspecific LBP. Pain intensity was measured monthly over a 1-year period by mobile phone short message service. Cluster analysis was used to identify participants with similar fluctuating patterns of pain based on the pain measures collected over a year, and t tests were used to evaluate if the clusters differed in terms of baseline characteristics. Results The cluster analysis revealed the presence of 3 main clusters. Pain was of fluctuating nature within 2 of the clusters. Out of the 155 participants, 21 (13.5%) had fluctuating pain. Baseline disability (measured with the Roland-Morris Disability Questionnaire) and treatment groups (from the initial randomized controlled trial) were significantly different in the clusters of patients with fluctuating pain when compared with the cluster of patients without fluctuating pain. Limitations A limitation of this study was the fact that participants were undergoing treatment that may have been responsible for the rather positive prognosis observed. Conclusions A small number of patients with fluctuating patterns of pain over time were identified. This number could increase if individuals with episodic pain are included in this fluctuating group. PMID:24072729

  17. Developmentally Delayed Male with Mincer Blade Obstructing the Oesophagus for a Period of Time Suspected to Be 6 Months

    PubMed Central

    Grønhøj Larsen, Christian; Charabi, Birgitte

    2015-01-01

    Introduction. Sharp, retained foreign bodies in the oesophagus are associated with severe complications. Developmentally delayed patients are especially subject to foreign objects. We describe a 37-year-old, developmentally delayed male with a mincer blade obstructing the oesophagus. Six months prior to surgical intervention, the patient was hospitalized in a condition of sepsis and pneumonia where the thoracic X-ray reveals a foreign body in the proximal oesophagus. When rehospitalized 6 months later, a mincer blade of the type used in immersion blenders was surgically removed. During these 6 months the patient's main symptoms were dysphagia, weight loss, and diarrhoea. When developmentally delayed patients present with dysphagia, we strongly encourage the awareness of the possible presence of foreign bodies. To our knowledge this is the first reported case of a mincer blade in the oesophagus. PMID:26236532

  18. 38 CFR 6.7 - Claims of creditors, taxation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Claims of creditors, taxation. 6.7 Section 6.7 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS UNITED... creditors, taxation. (a) Effective January 1, 1958, payments of insurance to a beneficiary under a...

  19. 20 CFR 404.471 - Nonpayment of disability benefits for trial work period service months upon a conviction of...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... another identity (this would include working under another social security number or a forged social... 404.471 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY... disability benefits under title II of the Social Security Act are not payable for months in which...

  20. 20 CFR 404.471 - Nonpayment of disability benefits for trial work period service months upon a conviction of...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... another identity (this would include working under another social security number or a forged social... 404.471 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY... disability benefits under title II of the Social Security Act are not payable for months in which...

  1. 20 CFR 404.471 - Nonpayment of disability benefits for trial work period service months upon a conviction of...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... another identity (this would include working under another social security number or a forged social... 404.471 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY... disability benefits under title II of the Social Security Act are not payable for months in which...

  2. Changes in volume during the four months' remodelling period of iliac crest grafts in reconstruction of the alveolar ridge.

    PubMed

    Dreiseidler, Timo; Kaunisaho, Veronika; Neugebauer, Jörg; Zöller, Joachim E; Rothamel, Daniel; Kreppel, Matthias

    2016-09-01

    Our aim was to assess the four months' resorption rates of onlay iliac crest grafts in atrophic jaws prospectively, and to identify factors that influence them. Twenty-four patients had reconstructions of the alveolar ridge with iliac crest onlay grafts at 30 sites on the mandibles and maxillas. The augmentation volumes were measured on cone-beam computed tomographic (CT) data-sets directly after augmentation (V1), and after four months' remodelling (V2). Statistical analysis allowed identification of potential influences from the recipient sites, volume of the graft, and the patients' smoking behaviour. The mean (range) initial onlay graft volume (V1) was 2.82 (0.66 to 6.41) ml. After four months, the mean measured onlay graft volume (V2) was 2.39 (0.47 to 6.21) ml. Mean iliac crest onlay graft volume resorption after four months of remodelling was 0.43 (-0.15 - 1.78) ml (15%). We found no significant differences in the resorption rates of iliac crest onlay grafts between different recipient sites (maxilla and mandible) or in dependence on the volume of iliac crest grafts. Smokers tended to have a higher rate of resorption, but not significantly so (p=0.056). The results of this study indicate the most favourable resorption rates for iliac crest onlay grafts that we know have seen published to date. PMID:27185231

  3. Video Evidence That London Infants Can Resettle Themselves Back to Sleep After Waking in the Night, as well as Sleep for Long Periods, by 3 Months of Age

    PubMed Central

    Hovish, Kimberly; Owen, Charlie

    2015-01-01

    ABSTRACT: Objective: Most infants become settled at night by 3 months of age, whereas infants not settled by 5 months are likely to have long-term sleep-waking problems. We assessed whether normal infant development in the first 3 months involves increasing sleep-period length or the ability to resettle autonomously after waking in the night. Methods: One hundred one infants were assessed at 5 weeks and 3 months of age using nighttime infrared video recordings and parental questionnaires. Results: The clearest development was in sleep length; 45% of infants slept continuously for ≥5 hours at night at 3 months compared with 10% at 5 weeks. In addition, around a quarter of infants woke and resettled themselves back to sleep in the night at each age. Autonomous resettling at 5 weeks predicted prolonged sleeping at 3 months suggesting it may be a developmental precursor. Infants reported by parents to sleep for a period of 5 hours or more included infants who resettled themselves and those with long sleeps. Three-month olds fed solely breast milk were as likely to self-resettle or have long sleep bouts as infants fed formula or mixed breast and formula milk. Conclusions: Infants are capable of resettling themselves back to sleep in the first 3 months of age; both autonomous resettling and prolonged sleeping are involved in “sleeping through the night” at an early age. Findings indicate the need for physiological studies of how arousal, waking, and resettling develop into sustained sleeping and of how environmental factors support these endogenous and behavioral processes. PMID:26035139

  4. Presence of epoxide hydrolase activity in Aspergillus niger: Hydrolysis of 6', 7'-epoxybergamottin to 6', 7'-dihydroxybergamottin

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The 6', 7'-epoxybergamottin (EB) is one of major furanocoumarins in grapefruit. Previously, we have shown that Aspergillus niger has a capability of metabolizing EB into 6', 7'-dihydroxybergamottin (DHB), which is further metabolized to bergaptol and bergaptol-5-sulfate in vivo. In this study, we at...

  5. Comparison of Conventional and Standardized Bone Densitometry around Implants in Periapical Radiographs during a Three Months Period

    PubMed Central

    Naser, Asieh Zamani; Etemadi, Shahab; Rismanchian, Mansour; Sheikhi, Mahnaz; Tavakoli, Mohammadbagher

    2011-01-01

    Background: Comparing continuous films taken at different timescales is a way to study the alveolar bone changes around the implant over time. One of the important concerns in quantitative analysis of the alveolar bone changes over the time is to reduce variations in the X-ray imaging geometry and image density. Methods: Using a modified XCP film holder together with the bite recording material, parallel periapical radiographs were taken from the implants placements of 16 patients in four steps. Densities of radiographs were measured in a conventional way using the video densitometry device. The same films were also scanned; sequential radiographic density of each patient was homogenised and the density was measured. Density changes obtained in both methods were compared. The data were evaluated using ANOVA, paired t-test and Pearson correlation (α = 0.05). Results: In the conventional method of densitometry, the average densities were as follows: before operation 1.0044, after one week 0.9600, after one month 0.9469 and after three months 0.9398. Also, in the standard method of densitometry, the average densities were as follows: before operation 111.7013, after one week 113.4225, after one month 119.4075 and after three months 131.1162. Average density in conventional densitometry were not significantly different in various time stages (P = 0.395). But, the standard densitometry method showed a significant difference (P = 0.001). Conclusion: The average density obtained at different stages in the standard densitometry showed a gradual increase in the bone density in the entire process. Standardising the patient's consecutive radiographic images is essential for quantitative measurements over the time. PMID:22132013

  6. Knee Muscles Isokinetic Evaluation after a Six-Month Regular Combined Swim and Dry-Land Strength Training Period in Adolescent Competitive Swimmers

    PubMed Central

    Dalamitros, Athanasios A.; Manou, Vasiliki; Christoulas, Kosmas; Kellis, Spiros

    2015-01-01

    Previous studies demonstrated significant increases in the shoulder internal rotators’ peak torque values and unilateral muscular imbalances of the shoulder rotators after a competitive swim period. However, there are no similar data concerning the knee muscles. The purpose of the current study was to examine the effects of a six-month training period on knee flexor and extensor peak torque values, examine a possible bilateral strength deficit and evaluate the unilateral strength balance in competitive swimmers. Eleven male adolescent swimmers (age: 14.82 ± 0.45 years) were tested for concentric knee extension and flexion peak torque (60°/s) with an isokinetic dynamometer, before and after a regular combined swim and dry-land strength training period. A trend towards greater improvements in the knee extensor compared to flexor muscles peak torque was observed. Furthermore, the bilateral strength deficit remained almost unchanged, whereas unilateral strength imbalance was increased for both limbs. However, all results were non-significant (p > 0.05). According to the data presented, a six-month regular combined swim and dry-land strength training period caused non-significant alterations for all the parameters evaluated during isokinetic testing. This study highlights the fact that competitive adolescent swimmers demonstrated unilateral knee strength imbalances throughout a long period of their yearly training macrocycle. PMID:26839619

  7. Knee Muscles Isokinetic Evaluation after a Six-Month Regular Combined Swim and Dry-Land Strength Training Period in Adolescent Competitive Swimmers.

    PubMed

    Dalamitros, Athanasios A; Manou, Vasiliki; Christoulas, Kosmas; Kellis, Spiros

    2015-12-22

    Previous studies demonstrated significant increases in the shoulder internal rotators' peak torque values and unilateral muscular imbalances of the shoulder rotators after a competitive swim period. However, there are no similar data concerning the knee muscles. The purpose of the current study was to examine the effects of a six-month training period on knee flexor and extensor peak torque values, examine a possible bilateral strength deficit and evaluate the unilateral strength balance in competitive swimmers. Eleven male adolescent swimmers (age: 14.82 ± 0.45 years) were tested for concentric knee extension and flexion peak torque (60°/s) with an isokinetic dynamometer, before and after a regular combined swim and dry-land strength training period. A trend towards greater improvements in the knee extensor compared to flexor muscles peak torque was observed. Furthermore, the bilateral strength deficit remained almost unchanged, whereas unilateral strength imbalance was increased for both limbs. However, all results were non-significant (p > 0.05). According to the data presented, a six-month regular combined swim and dry-land strength training period caused non-significant alterations for all the parameters evaluated during isokinetic testing. This study highlights the fact that competitive adolescent swimmers demonstrated unilateral knee strength imbalances throughout a long period of their yearly training macrocycle. PMID:26839619

  8. Prophylaxis with diphenylhydantoin and phenobarbital in alumina-gel monkey model. II. Fourth-month follow-up period: seizure, EEG, blood and behavioral data.

    PubMed

    Lockard, J S; DuCharme, L L; Congdon, W C; Franklin, S C

    1976-03-01

    This study, a 4-month follow-up period of a 12-month treatment study by the present authors, was concerned with the permanent effects of treatment with diphenylhydantoin and phenobarbital in the alumina-gel monkey model. Whereas the 8 drug animals during withdrawal increased their seizure frequency, duration, and severity, those 4 animals having received 120 mg/kg/day DPH in weeks 6-12 had one-half the number of seizures of the 4 placebo monkeys in the follow-up period. The other 4 drug animals who had continued to receive 60 mg/kg/day DPH during those weeks had two to four times the number of seizures of the placebo group during posttreatment. (All drug monkeys received 80 mg/kg/day of DPH from weeks 13-52 and 6 mg/kg/day of phenobarbital throughout the 12-month treatment period). The results reaffirm the problems of drug withdrawal and the importance of altering seizure mechanisms with sufficiently high doses of efficacious anticonvulsants rather than merely treating epileptic manifestations at lower doses. PMID:817892

  9. Methane and carbon dioxide emissions from dairy cows in full lactation monitored over a six-month period.

    PubMed

    Kinsman, R; Sauer, F D; Jackson, H A; Wolynetz, M S

    1995-12-01

    Methane and CO2 emissions from a herd of 118 lactating cows were measured directly by continuous monitoring with an infrared gas analyzer from 24 gas sampling locations. A total of 112 d of gas output was recorded between June 1993 and November 1993. Recordings were integrated at .5-h intervals, so that there were 48 data points for each 24-h period. The mean 24-h CH4 emission per cow was 587 +/- 61.3 L; the range was 436 to 721 L. The mean 24-h CO2 emission per cow was 6137 +/- 505 L, and the range was 5032 to 7427 L. These values were not corrected for gas emissions from stored manure, which contributed 5.8 and 6.1%, respectively, to CH4 and CO2 output under conditions of this experiment. PMID:8675759

  10. ANTIBODY RESPONSE TO EPSILON TOXIN OF CLOSTRIDIUM PERFRINGENS IN CAPTIVE RED DEER (CERVUS ELAPHUS) OVER A 13-MONTH PERIOD.

    PubMed

    Scala, Christopher; Duffard, Nicolas; Beauchamp, Guy; Boullier, Séverine; Locatelli, Yann

    2016-03-01

    Deer are sensitive to clostridial diseases, and vaccination with clostridial toxoids is the method of choice to prevent these infections in ruminants. The purpose of this study was to evaluate the serologic responses in red deer (Cervus elaphus) over a 13-mo period after vaccination with a multivalent clostridial vaccine, containing an aluminium hydroxide adjuvant. Antibody production to the Clostridium perfringens type D epsilon toxin component of the vaccine was measured using an indirect enzyme-linked immunosorbent assay. Animals from group 1 (9 mo old; n = 6) were naïve and received an initial vaccination with a booster vaccine 4 wk apart and one annual booster. Animals from group 2 (21 mo old; n = 10) had been previously vaccinated 12 mo prior and received a first annual booster at the beginning of this study and a second annual booster 12 mo later. The multivalent clostridial vaccine induced a high antibody response that peaked after each injection and then slowly decreased with time. In group 1, a booster vaccine was required to obtain an initial high humoral response. The annual booster injection induced a strong, rapid, and consistent anamnestic response in both groups. The serologic responses persisted significantly over the baseline value for 9-12 mo in group 1, but more than 12 mo in group 2. It is unknown whether the measured humoral immune responses would have been protective as no challenge studies were performed. Further investigation is needed to determine the protective antibody titers to challenge and how long this immunity might persist after vaccination. PMID:27010263

  11. The Most Frequent Causes of Hospitalization of Iranian Pilgrims in Iraq During a 5-Month Period in 2012, and Their Outcome

    PubMed Central

    Sadeghi, Soleiman; Heidari, Ali; Fazli, Hosein; Rezaei, Mashallah; Sheikhzadeh, Javad

    2015-01-01

    Background: Investigating the prevalence of diseases and causes of hospitalization of Iranian pilgrims in Iraq can be helpful for healthcare programmers in scheduling a healthy and joyful trip for pilgrims and reducing their mortality and morbidity. Objectives: The main purpose of this study was to determine the frequency of Iranian pilgrims’ referral cases to Karbala and Najaf hospitals in Iraq during a 5-month period in 2012. Patients and Methods: In this cross-sectional study, medical records of all patients referred to Iraqi hospitals from Iranian clinics during a 5-month period from 16 January 2012 until 14 June 2012 was recorded. A checklist, including demographic data and diagnostic causes were prepared and completed by general practitioners. Then, the completed forms were checked and delivered to health surveillance supervisors. Results: A total of 177 referral cases from Iranian clinics to Iraqi hospitals were recorded in 5 months. Most of these referrals were due to cardiovascular diseases with 38.6%, then comes trauma with 26.55%, and finally renal failure in need of dialysis with 12.43%. About 80.2% of the patients were discharged, 13% of them were sent to Iran, and 6.2% died. Around 90% of deaths were due to heart diseases. Conclusions: Considering the high prevalence of cardiovascular diseases and fractures in Iranian pilgrims, the necessity of self-care education to diminish such rates is substantial. PMID:26730348

  12. Estimates of monthly streamflow characteristics at selected sites in the upper Missouri River basin, Montana, base period water years 1937-86

    USGS Publications Warehouse

    Parrett, Charles; Johnson, D.R.; Hull, J.A.

    1989-01-01

    Estimates of streamflow characteristics (monthly mean flow that is exceeded 90, 80, 50, and 20 percent of the time for all years of record and mean monthly flow) were made and are presented in tabular form for 312 sites in the Missouri River basin in Montana. Short-term gaged records were extended to the base period of water years 1937-86, and were used to estimate monthly streamflow characteristics at 100 sites. Data from 47 gaged sites were used in regression analysis relating the streamflow characteristics to basin characteristics and to active-channel width. The basin-characteristics equations, with standard errors of 35% to 97%, were used to estimate streamflow characteristics at 179 ungaged sites. The channel-width equations, with standard errors of 36% to 103%, were used to estimate characteristics at 138 ungaged sites. Streamflow measurements were correlated with concurrent streamflows at nearby gaged sites to estimate streamflow characteristics at 139 ungaged sites. In a test using 20 pairs of gages, the standard errors ranged from 31% to 111%. At 139 ungaged sites, the estimates from two or more of the methods were weighted and combined in accordance with the variance of individual methods. When estimates from three methods were combined the standard errors ranged from 24% to 63 %. A drainage-area-ratio adjustment method was used to estimate monthly streamflow characteristics at seven ungaged sites. The reliability of the drainage-area-ratio adjustment method was estimated to be about equal to that of the basin-characteristics method. The estimate were checked for reliability. Estimates of monthly streamflow characteristics from gaged records were considered to be most reliable, and estimates at sites with actual flow record from 1937-86 were considered to be completely reliable (zero error). Weighted-average estimates were considered to be the most reliable estimates made at ungaged sites. (USGS)

  13. 47 CFR 6.7 - Product design, development, and evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... individuals with disabilities in target populations of such research; (2) Where product design, testing, pilot... 47 Telecommunication 1 2011-10-01 2011-10-01 false Product design, development, and evaluation. 6... Obligations-What Must Covered Entities Do? § 6.7 Product design, development, and evaluation....

  14. 47 CFR 6.7 - Product design, development, and evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Product design, development, and evaluation. 6... Obligations-What Must Covered Entities Do? § 6.7 Product design, development, and evaluation. (a... and services covered by this part and shall incorporate such evaluation throughout product...

  15. A multicenter, open-label extension study of velaglucerase alfa in Japanese patients with Gaucher disease: Results after a cumulative treatment period of 24months.

    PubMed

    Ida, Hiroyuki; Tanaka, Akemi; Matsubayashi, Tomoko; Murayama, Kei; Hongo, Teruaki; Lee, Hak-Myung; Mellgard, Björn

    2016-07-01

    Enzyme replacement therapy (ERT) with exogenous glucocerebrosidase is indicated to treat symptomatic Gaucher disease (GD), a rare, inherited metabolic disorder. ERT with velaglucerase alfa, which is produced in a human cell line using gene activation technology, was studied in a 12-month phase III trial in Japanese patients with type 1 or 3 GD who were switched from imiglucerase ERT (n=6); the current, open-label, 12-month extension study was designed to assess longer-term safety and efficacy. Two adult and three pediatric patients (aged <18years) were enrolled into the extension study. Every-other-week intravenous infusions were administered for 63-78weeks at average doses between 51.5 and 60.7units/kg. Three non-serious adverse events were considered related to velaglucerase alfa treatment, but no patient discontinued from the study. Six serious but non-drug-related adverse events were reported. No patient tested positive for anti-velaglucerase alfa antibodies. Hemoglobin concentrations, platelet counts, and liver and spleen volumes (normalized to body weight) in these patients were generally stable over a cumulative 24-month period from the baseline of the parent trial. The data suggest that velaglucerase alfa was well tolerated and maintained clinical stability in Japanese GD patients over 2years after switching from imiglucerase. ClinicalTrials.gov identifier NCT01842841. PMID:27241455

  16. Effects of consumption of edible oils for a period of 4 months on the ultrastructure of the aorta of spontaneously hypertensive rats.

    PubMed

    Faizah, O; Merican, Z; Hassan, M F; Khalid, B A; Mohamed, J; Radzi, M

    1999-06-01

    Edible oils have different effects on lipid profiles and on the propensity for producing lipid peroxidation products. These two properties of edible oils can affect arterial structure, ultimately leading to atherosclerosis. Hypertension is said to be a predisposing factor for atherosclerosis and can accelerate its process. This paper investigates the effects of three edible oils, namely soya bean oil, palm oil and ghee, on the ultrastructure of the aortas of spontaneously hypertensive rats at the end of a 4 month feeding period. It was found that ghee produced significant structural changes to the aortic wall when compared with palm oil or soya bean oil, and that no noticeable structural differences were seen to occur on the aortas of the palm oil-fed and soya bean oil-fed groups of rats. This study suggests that the consumption of ghee, rather than palm or soya bean oil, is more likely to lead to the development of atherosclerosis. PMID:24393793

  17. [Corpse disposal by embedding it in concrete--a rare form of preserving a body over a period of 5 years and 10 months].

    PubMed

    Doberentz, Elke; Wöllner, Kirsten; Madea, Burkhard

    2014-01-01

    Final disposal of a homicide victim in concrete is rare. Often missing persons are reported to the police, but the right of adults to determine their whereabouts can make it very difficult to locate them. A 40-year-old woman had been missing for 5 years and 10 months. She was found by the police in the cellar of the family's house, packed in airtight plastic film and embedded in concrete. The husband admitted to have killed her by manual strangulation after an argument during which she fell on the head. His statements were confirmed by the findings obtained from the very well preserved body. The autopsy results were generally consistent with manual strangulation. The literature does not contain many case reports on this rare method of disposing of a body. In the reported case, the postmortem period was remarkably long and the corpse was in a good state of preservation. PMID:26548026

  18. Tracking the monthly changes of dissolved organic matter composition in a newly constructed reservoir and its tributaries during the initial impounding period.

    PubMed

    Chen, Meilian; He, Wei; Choi, Ilhwan; Hur, Jin

    2016-01-01

    Understanding the roles of inland reservoirs becomes increasingly important with respect to global carbon cycling as well as water resource management due to the unprecedented demand for construction in recent decades. In this study, the dissolved organic matter (DOM) quantity and quality in a newly constructed dam reservoir and its tributaries were monitored monthly during the initial impounding period (July to November 2014) using a size exclusion chromatography (SEC) with online organic carbon detector (OCD). The highest values were observed in the month of August with the highest precipitation for the bulk dissolved organic carbon (DOC), specific UV absorbance (SUVA), and most of the assigned size fractions (except for biopolymers) in the tributaries, indicating that allochthonous sources of DOM were dominant in the feeding stream waters of the reservoir. The bulk DOC and high molecular weight humic substance fraction (∼1 kDa) were generally co-varied with the monthly precipitation in the tributaries, while building blocks (350-500 Da), and low molecular weight (LMW) acids and neutrals showed different trends. In a dam site, the smaller molecular fractions became more abundant during the dry season (September to November), presumably due to the in-reservoir processes such as photo- and bio-degradation. Our results also revealed that storms mobilized a large amount of highly aromatic soil-derived DOM to the reservoir. A depth profile at the dam site showed the water is well mixed up to a depth of ∼20 m. The SEC-OCD data coupled with non-metric multidimensional scaling provided a clear visualization of the spatiotemporal variations in DOM composition, which shed new light on the DOM composition formed in a newly constructed dam reservoir and also on the strategies for future water treatment options. PMID:26358212

  19. Remission in schizophrenia: results of cross-sectional with 6-month follow-up period and 1-year observational therapeutic studies in an outpatient population

    PubMed Central

    2012-01-01

    Background A standardized definition of remission criteria in schizophrenia was proposed by the International group of NC Andreasen in 2005 (low symptom threshold for the eight core Positive and Negative Syndrome Scale (PANSS) symptoms for at least 6 consecutive months). Methods A cross-sectional study of remission rate, using a 6-month follow-up to assess symptomatic stability, was conducted in two healthcare districts (first and second) of an outpatient psychiatric service in Moscow. The key inclusion criteria were outpatients with an International Classification of Diseases, 10th edition (ICD-10) diagnosis of schizophrenia or schizoaffective disorder. Remission was assessed using modern criteria (severity and time criteria), PANSS and Global Assessment of Functioning (GAF). Patients who were stable but did not satisfied the symptomatic criteria were included in a further 1-year observational study, with the first group (first district) receiving risperidone (long-acting, injectable) (RLAI) and the second group (second district) continuing to receiving routine treatment. Symptoms were assessed with PANSS, social functioning with the personal and social performance scale, compliance with rating of medication influences scale, and extrapyramidal side effects with the Simpson-Angus scale. Results Only 64 (31.5%) of 203 outpatients met the criteria for symptomatic remission in the cross-sectional study, but at the end of the 6-month follow-up period, 158 (77.8%) were stable (irrespective of remission status). Among these only 53 (26.1%) patients fulfilled the remission criteria. The observational study had 42 stable patients in the RLAI group and 35 in the routine treatment group: 19.0% in the RLAI group and 5.7% in the control group met remission criteria after 12 months of therapy. Furthermore, reduction of PANSS total and subscale scores, as well as improvement in social functioning, was more significant in the first group. Conclusions Only around one-quarter of

  20. Discovery of periodic class II methanol masers associated with G339.986-0.425 region

    NASA Astrophysics Data System (ADS)

    Maswanganye, J. P.; van der Walt, D. J.; Goedhart, S.; Gaylard, M. J.

    2016-03-01

    10 new class II methanol masers from the 6.7-GHz Methanol Multibeam survey catalogues III and IV were selected for a monitoring programme at both 6.7 and 12.2 GHz with the 26-m Hartebeesthoek Radio Astronomy Observatory radio telescope for 2 yr and 9 months, from 2012 August to 2015 May. In the sample, only masers associated with G339.986-0.425 were found to show periodic variability at both 6.7 and 12.2 GHz. The existence of periodic variation was tested with four independent methods. The analytical method gave the best estimation of the period, which was 246 ± 1 d. The time series of G339.986-0.425 show strong correlations across velocity channels and between the 6.7- and 12.2-GHz masers. The time delay was also measured across channels and shows structure across the spectrum which is continuous between different maser components.

  1. 6,7-diepicastanospermine, a tetrahydroxyindolizidine alkaloid inhibitor of amyloglucosidase

    SciTech Connect

    Molyneux, R.J.; Benson, M. ); Pan, Y.T.; Tropea, J.E.; Kaushal, G.P.; Elbein, A.D. )

    1991-10-15

    A tetrahydroxyindolizidine alkaloid, 6,7-diepicastanospermine, was isolated from the seeds of Castanospermum australe by extraction with methanol and purified to homogeneity using ion-exchange, preparative thin-layer, and radial chromatography. A very low yield of a pyrrolidine alkaloid, N-(hydroxyethyl)-2-(hydroxymethyl)-3-hydroxypyrrolidine, was also obtained by analogous methods. The purity of both alkaloids was established by gas chromatography of their trimethylsilyl (TMS) derivatives as better than 99%. The molecular weight of each alkaloid was established as 189 and 161, respectively, by mass spectrometry, and the structure of each was deduced from their {sup 1}H and {sup 13}C NMR spectra. The structure of the pyrrolidine alkaloids which co-occur in C. australe. 6,7-Diepicastanospermine was found to be a moderately good inhibitor of the fungal {alpha}-glucosidase, amyloglucosidase and a relatively weak inhibitor of {beta}-glucosidase. It failed to inhibit {alpha}-glucosidase. It failed to inhibit {alpha}- or {beta}-galactosidase, {alpha}- or {beta}-mannosidase, or {alpha}-L-fucosidase. Comparison of its inhibitory activity toward amyloglucosidase with those of its isomers, castanospermine and 6-epicastanospermine, demonstrated that epimerization of a single hydroxyl group can produce significant alteration of such inhibitory properties.

  2. Exercise, character strengths, well-being, and learning climate in the prediction of performance over a 6-month period at a call center

    PubMed Central

    Moradi, Saleh; Nima, Ali A.; Rapp Ricciardi, Max; Archer, Trevor; Garcia, Danilo

    2014-01-01

    Background: Performance monitoring might have an adverse influence on call center agents' well-being. We investigate how performance, over a 6-month period, is related to agents' perceptions of their learning climate, character strengths, well-being (subjective and psychological), and physical activity. Method: Agents (N = 135) self-reported perception of the learning climate (Learning Climate Questionnaire), character strengths (Values In Action Inventory Short Version), well-being (Positive Affect, Negative Affect Schedule, Satisfaction With Life Scale, Psychological Well-Being Scales Short Version), and how often/intensively they engaged in physical activity. Performance, “time on the phone,” was monitored for 6 consecutive months by the same system handling the calls. Results: Performance was positively related to having opportunities to develop, the character strengths clusters of Wisdom and Knowledge (e.g., curiosity for learning, perspective) and Temperance (e.g., having self-control, being prudent, humble, and modest), and exercise frequency. Performance was negatively related to the sense of autonomy and responsibility, contentedness, the character strengths clusters of Humanity and Love (e.g., helping others, cooperation) and Justice (e.g., affiliation, fairness, leadership), positive affect, life satisfaction and exercise Intensity. Conclusion: Call centers may need to create opportunities to develop to increase agents' performance and focus on individual differences in the recruitment and selection of agents to prevent future shortcomings or worker dissatisfaction. Nevertheless, performance measurement in call centers may need to include other aspects that are more attuned with different character strengths. After all, allowing individuals to put their strengths at work should empower the individual and at the end the organization itself. Finally, physical activity enhancement programs might offer considerable positive work outcomes. PMID:25002853

  3. Sea surface temperatures in the central southern Indian Ocean over the period 1790 to 2007 inferred from two monthly resolved Sr/Ca and oxygen isotope records

    NASA Astrophysics Data System (ADS)

    Zinke, J.; Wassenburg, J.; Hardman, E.

    2009-04-01

    We obtained two monthly resolved Sr/Ca records from Rodrigues island (Mauritius) located in the trade wind belt of the central southern Indian Ocean. The longest core was obtained at a nearshore fringing reef and covers the period 1790-2005. This coral records surface air temperatures from the local weather station available from 1950 to the present. The most remarkable signal is a slight cooling after the 1950's. The second core was obtained from the open ocean and records a long-term warming trend between 1947 to 2007. The warming accelerated after the late 1970's in agreement with instrumental data. The oxygen isotope record is affected by salinity variations and shows a strong freshening trend after the late 1970's. The freshening trend is probably related to advection of low salinity waters with the South Equatorial Current and/or increased cyclonicity. We will discuss our results in light of interannual and decadal variability and present long-term seawater monitoring data.

  4. Summary of Sonic Boom Rise Times Observed During FAA Community Response Studies over a 6-Month Period in the Oklahoma City Area

    NASA Technical Reports Server (NTRS)

    Maglieri, Domenic J.; Sothcott, Victor E.

    1990-01-01

    The sonic boom signature data acquired from about 1225 supersonic flights, over a 6-month period in 1964 in the Oklahoma City area, was enhanced with the addition of data relating to rise times and total signature duration. These later parameters, not available at the time of publication of the original report on the Oklahoma City sonic boom exposures, are listed in tabular form along with overpressure, positive impulse, positive duration, and waveform category. Airplane operating information along with the surface weather observations are also included. Sonic boom rise times include readings to the 1/2, 3/4, and maximum overpressure values. Rise time relative probabilities for various lateral locations from the ground track of 0, 5, and 10 miles are presented along with the variation of rise times with flight altitude. The tabulated signature data, along with corresponding airplane operating conditions and surface and upper level atmospheric information, are also available on electronic files to provide it in the format for more efficient and effective utilization.

  5. Survey of construction workers repeatedly exposed to chlorine over a three to six month period in a pulpmill: I. Exposure and symptomatology.

    PubMed Central

    Courteau, J P; Cushman, R; Bouchard, F; Quévillon, M; Chartrand, A; Bhérer, L

    1994-01-01

    OBJECTIVE--The admission to hospital of three construction workers with acute respiratory distress caused by inhalation of chlorine gas prompted the inspection of a building site located in a kraft pulpmill. The accidental emissions had taken place in the bleach plant and the construction workers assigned there were surveyed to uncover possible large scale health effects. DESIGN AND PARTICIPANTS--A questionnaire was presented to 281 workers (participation rate = 97%); 257 workers reported an average of 24 exposure episodes to chlorine and derivatives over a three to six month period. The air monitoring data available from the pulpmill's industrial hygienist were not useful in linking specific events reported by the workers to environmental conditions in the bleach plant. RESULTS--Over 60% of the workers described a characteristic flu like syndrome that lasted for an average of 11 days and was exacerbated by new bouts of exposure. Irritation of the throat (78%) and eyes (77%), cough (67%), and headache (63%) were the most often reported symptoms. Shortness of breath was reported by 54% of the participants and was not associated with age, smoking state, or history of asthma or chronic bronchitis. First aid self referral was associated with significantly greater reporting of most symptoms, including dyspnoea and cough. A significantly greater proportion of workers in the dyspnoea group had gone at least once for first aid care after a gassing incident (64% as opposed to 48%, p = 0.008). Throat irritation and cough persisted for mean intervals of eight and 11 days respectively. A flu like syndrome lasted for an average of 20 days. Seventy one subjects were considered to be a moderate to high risk of having persisting respiratory symptoms. CONCLUSION--Throat and eye irritation as well as cough and flu like symptoms are frequent occurrences after repeated accidental inhalation of chlorine. Subjects who consulted first aid care stations after a gassing incident are more

  6. Incidence and Determinants of Endophthalmitis within 6 Months of Surgeries over a 2-Year Period at King Khaled Eye Specialist Hospital, Saudi Arabia: A Review

    PubMed Central

    Khandekar, Rajiv; Al-Motowa, Saeed; Alkatan, Hind M.; Karaoui, Mohammed; Ortiz, Anne

    2015-01-01

    Background: We present the incidence and determinants of endophthalmitis between July 2010 and June 2012 at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. On its basis, we recommended recommendations to strengthen the infection prevention and control strategies. Methods: This is a retrospective review of health records type of study. The details of cases reported having endophthalmitis among those operated in 2 years of study period were studied. The incidence of endophthalmitis was calculated for different eye surgeries and epidemiological variables. The causative organisms in vitreous tap were reviewed. The visual outcomes 6 weeks following intervention/treatment of endophthalmmitis were also studied. Results: Of the 22,554 cases operated, 17 developed endophthalmitis. The incidence was 0.08% (95% confidence interval [CI] 0.04–0.11). The incidence of endophthlamitis among cataract surgeries was 0.12% (95% CI 0.04–0.21). Five specimens did not show any bacteria or fungus. Staphylococcus epidermis (3 cases) was the main pathogen identified. In 8 (47%) eyes, vision deteriorated in spite of treatment. In 5 (29%) eyes, it became stable and in 4 (23.5%) eyes, it improved following treatment. Signs of infection were noted in 1st week, 3 weeks and 12 weeks in 4, 6 and 5 eyes respectively. Late presentation of infection (6 months postoperatively) was reported in two eyes. Conclusions: A vigilant infection control unit in a large eye hospital helps in monitoring endophthalmitis related catastrophes and suggests timely preventive measures to reduce the occurrence and appropriate measures to limit visual disabilities following eye surgery related endophthalmitis. PMID:25949078

  7. Acceptance of an assistive robot in older adults: a mixed-method study of human–robot interaction over a 1-month period in the Living Lab setting

    PubMed Central

    Wu, Ya-Huei; Wrobel, Jérémy; Cornuet, Mélanie; Kerhervé, Hélène; Damnée, Souad; Rigaud, Anne-Sophie

    2014-01-01

    Background There is growing interest in investigating acceptance of robots, which are increasingly being proposed as one form of assistive technology to support older adults, maintain their independence, and enhance their well-being. In the present study, we aimed to observe robot-acceptance in older adults, particularly subsequent to a 1-month direct experience with a robot. Subjects and methods Six older adults with mild cognitive impairment (MCI) and five cognitively intact healthy (CIH) older adults were recruited. Participants interacted with an assistive robot in the Living Lab once a week for 4 weeks. After being shown how to use the robot, participants performed tasks to simulate robot use in everyday life. Mixed methods, comprising a robot-acceptance questionnaire, semistructured interviews, usability-performance measures, and a focus group, were used. Results Both CIH and MCI subjects were able to learn how to use the robot. However, MCI subjects needed more time to perform tasks after a 1-week period of not using the robot. Both groups rated similarly on the robot-acceptance questionnaire. They showed low intention to use the robot, as well as negative attitudes toward and negative images of this device. They did not perceive it as useful in their daily life. However, they found it easy to use, amusing, and not threatening. In addition, social influence was perceived as powerful on robot adoption. Direct experience with the robot did not change the way the participants rated robots in their acceptance questionnaire. We identified several barriers to robot-acceptance, including older adults’ uneasiness with technology, feeling of stigmatization, and ethical/societal issues associated with robot use. Conclusion It is important to destigmatize images of assistive robots to facilitate their acceptance. Universal design aiming to increase the market for and production of products that are usable by everyone (to the greatest extent possible) might help to

  8. Resolving distance ambiguities towards 6.7 GHz methanol masers

    NASA Astrophysics Data System (ADS)

    Pandian, J. D.; Momjian, E.; Goldsmith, P. F.

    2008-07-01

    Context: Distances to most star forming regions are determined using kinematics, through the assumption that the observed radial velocity arises from the motion of the source with respect to the Sun resulting from the differential rotation of Galaxy. The primary challenge associated with the application of this technique in the inner Galaxy is the kinematic distance ambiguity. Aims: In this work, we aim to resolve the kinematic distance ambiguity towards a sample of 6.7 GHz methanol masers, which are signposts of the early stages of massive star formation. Methods: We measured 21 cm H I absorption spectra using the Very Large Array in C and CnB configurations. A comparison of the maximum velocity of H I absorption with the source velocity and tangent point velocity was used to resolve the kinematic distance ambiguity. Results: We resolved the distance ambiguity towards 41 sources. Distance determinations that are in conflict with previous measurements are discussed. The NE2001 spiral arm model is broadly consistent with the locations of the star forming complexes. We find that the use of vertical scale height arguments to resolve the distance ambiguity can lead to erroneous classifications for a significant fraction of sources.

  9. Estimates of mean monthly streamflow for selected sites in the Musselshell River basin, Montana, base period water years 1937-86

    USGS Publications Warehouse

    Parrett, Charles; Johnson, D.R.

    1989-01-01

    Estimates of mean monthly and mean annual streamflow were made for 56 selected sites in the Musselshell River basin and 1 site outside the basin. The study area was divided into a Mountain Region and a Plains Region and the estimation methods were applied separately in the two regions. Four methods were developed to estimate mean monthly streamflow at ungaged sites. The first method was based on the regression relation between mean monthly streamflow and various basin and climatic characteristics. The standard errors ranged from 35 to 71% in the Mountain Region and from 98 to 157% in the Plains Region. The second method was based on the regression relations between mean monthly streamflow and active-channel width. The standard errors ranged from 38 to 81% in the Mountain Region and from 71 to 98% in the Plains Region. The third method was based on correlation of measured streamflow at ungaged sites with concurrent daily mean streamflow at nearby gaged sites. The standard errors ranged from 36 to 66% in the Mountain Region and from 109 to 321% in the Plains Region. The fourth method, generally the most reliable, estimated mean monthly streamflows by weighing individual estimates in accordance with their variance and degree of independence. The standard error for this method when all three individual estimates were weighed ranged from 25 to 55% in the Mountain Region and from 71 to 97% in the Plains Region. (USGS)

  10. Calcium supplementation, bone mineral density and bone mineral content. Predictors of bone mass changes in adolescent mothers during the 6-month postpartum period.

    PubMed

    Malpeli, Agustina; Apezteguia, María; Mansur, José L; Armanini, Alicia; Macías Couret, Melisa; Villalobos, Rosa; Kuzminczuk, Marta; Gonzalez, Horacio F

    2012-03-01

    We determined the effect of calcium supplementation on bone mineral density (BMD) and bone mineral content (BMC) and identified predictors of bone mass changes in adolescent mothers 6 months postpartum. A prospective, analytical, clinical study was performed in adolescent mothers (< or = 19 years old; n = 37) from La Plata, Argentina. At 15 days postpartum, mothers were randomly assigned into one of two groups and started with calcium supplementation; one group received dairy products (932 mg Ca; n = 19) and the other calcium citrate tablets (1000 mg calcium/day; n = 18). Weight, height and dietary intake were measured and BMD was determined by DEXA at 15 days (baseline) and 6 months postpartum. BMC, total body BMD and BMD were assessed in lumbar spine, femoral neck, trochanter and total hip. Regression models were used to identify the relationship of total body BMD and BMC with independent variables (calcium supplementation, months of lactation, weight at 6 months, percent weight change, lean mass at 6 months, percent lean mass change, total calcium intake). Results showed that changes in BMD and BMC at the different sites were similar in both groups, and changes in percent body weight and total calcium intake were the main predictive factors. In conclusion, the effect of calcium was similar with either form of supplementation, i.e., dairy products or tablets, and changes in percent body weight and total calcium intake were predictors of total body BMD and BMC changes. PMID:23477205

  11. Old-age, survivors, and disability insurance and Supplemental Security Income for the aged, blind, and disabled; substantial gainful activity amounts; "services" for trial work period purposes--monthly amounts; student child earned income exclusion. Social Security Administration. Final rules.

    PubMed

    2000-12-29

    We are revising the rules to automatically adjust each year, based on any increases in the national average wage index, the average monthly earnings guideline we use to determine whether work done by persons with impairments other than blindness is substantial gainful activity; provide that we will ordinarily find that an employee whose average monthly earnings are not greater than the "primary substantial gainful activity amount," has not engaged in substantial gainful activity without considering other information beyond the employee's earnings; increase the minimum amount of monthly earnings and the minimum number of self-employed work hours in month that we consider shows that a person receiving title II Social Security benefits based on disability is performing or has performed "services" during a trial work period, and automatically adjust the earnings amount each year thereafter; increase the maximum monthly and yearly Student Earned Income Exclusion amounts we use in determining Supplemental Security Income (SSI) Program eligibility and payment amounts for student children, and automatically adjust the monthly and yearly exclusion amounts each year thereafter. We are revising these rules as part of our efforts to encourage individuals with disabilities to test their ability to work and keep working. We expect that these changes will provide greater incentives for many beneficiaries to attempt to work or, if already working, to continue to work or increase their work effort. PMID:11503739

  12. Reproducibility of Retinol Binding Protein 4 and Omentin-1 Measurements over a Four Months Period: A Reliability Study in a Cohort of 207 Apparently Healthy Participants

    PubMed Central

    Wittenbecher, Clemens; di Giuseppe, Romina; Biemann, Ronald; Menzel, Juliane; Arregui, Maria; Hoffmann, Juliane; Aleksandrova, Krasimira; Boeing, Heiner; Isermann, Berend; Schulze, Matthias B.; Weikert, Cornelia

    2015-01-01

    The reliability of single time point measurements of the novel adipokines retinol-binding protein 4 and omentin-1 in the blood has not been evaluated in large samples yet. The present study aimed to assess the amount of biological variation of these two adipokines within individuals. The study sample comprised 207 participants (124 women and 83 men) from Potsdam (Germany) and surrounding areas, with an average age of 56.5 years (SD 4.2). Blood samples were collected from each participant twice, approximately four months apart. Using enzyme linked immunosorbent assays, the concentrations of retinol-binding protein 4 and omentin-1 were determined in EDTA plasma. As indicators of reliability, intraclass correlation coefficients (ICCs) were calculated from the repeated biomarker measurements. The ICCs for repeated retinol-binding protein 4 and omentin-1 measurements were 0.77 (95% CI 0.71, 0.82) and 0.83 (95% CI 0.78, 0.87), respectively, indicating for both adipokines excellent reliability. ICCs were stable across strata according to sex, age, BMI, and blood pressure. Thus, for epidemiological studies it seems reasonable to rely on concentrations of retinol-binding protein 4 and omentin-1 in samples from a single time point if repeated measurements are not available. PMID:26402656

  13. Effect of Intensive Salt-Restriction Education on Clinic, Home, and Ambulatory Blood Pressure Levels in Treated Hypertensive Patients During a 3-Month Education Period.

    PubMed

    Nakano, Masahiro; Eguchi, Kazuo; Sato, Toshiko; Onoguchi, Atsuko; Hoshide, Satoshi; Kario, Kazuomi

    2016-05-01

    The authors tested the hypothesis that low-salt diet education by nutritionists would lower blood pressure (BP) levels in treated hypertensive patients. The amount of urinary salt excretion and clinic, home, and ambulatory BP values at baseline and at 3 months were measured in 95 patients with hypertension. After randomization to a nutritional education group (E group, n=51) or a control group (C group, n=44), the C group received conventional salt-restriction education and the E group received intensive nutritional education aimed at salt restriction to 6 g/d by nutritionists. From baseline to the end of the study, 24-hour urinary sodium excretion was significantly lowered in the E group compared with the C group (6.8±2.9 g/24 h vs 8.6±3.4 g/24 h, P<.01). Morning home systolic BP tended to be lowered in the E group (P=.051), and ambulatory 24-hour systolic BP was significantly lowered in the E group (-4.5±1.3 mm Hg) compared with the C group (2.8±1.3 mm Hg, P<.001). Intensive nutritional education by nutritionists was shown to be effective in lowering BP in treated hypertensive patients. PMID:26732187

  14. Survey of lands held for uranium exploration, development, and production in fourteen western states in the six month period ending June 30, 1979

    SciTech Connect

    Not Available

    1980-01-01

    The statistics set forth for the period covered by this report are based on data gathered from records available to the public. These data were derived from public county records of mining claim locations, from the public reports of state and Federal land offices, from commercial reporting services, and from annual reports to stockholders of land companies. Accordingly, if any fee land has been acquired in a private transaction which has not been entered into a public record or report, that land will not be accounted for in this report. The figures for the acreage controlled at the beginning of the calendar year are those that were published for that date in the publication entitled Statistical Data of the Uranium Industry GJO-100(78).

  15. Synthesis and biological activity of substituted-4,5,6,7-tetrahydrothieno pyridines: a review.

    PubMed

    Sangshetti, Jaiprakash N; Zambare, Abhay S; Khan, Firoz A Kalam; Gonjari, Indrajeet; Zaheer, Zahid

    2014-01-01

    4,5,6,7-Tetrahydrothieno pyridine is an important class of heterocyclic nucleus. Various 4,5,6,7-tetrahydrothieno pyridine derivatives have been synthesized and evaluated for various biological activities in different models with desired findings. Some analogs have shown potent biological activities and may be considered as lead molecule for the development of future drugs. Number of drug molecules are available in the market and many molecules are in clinical development containing 4,5,6,7-tetrahydrothieno pyridine nucleus as an important core. This review is an attempt to organize the chemical and biological aspects of 4,5,6,7-tetrahydrothieno pyridine analogs reported in last 20 year to till date. Review mainly focuses on the important role of the core in synthesis of drug or drug intermediates giving emphasis on synthetic schemes and biological activities of the different 4,5,6,7-tetrahydrothieno pyridine analogs. PMID:25373848

  16. Treatment of rats with an anti-(+)-methamphetamine monoclonal antibody shortens the duration of action of repeated (+)-methamphetamine challenges over a one month period

    PubMed Central

    Hambuchen, Michael D.; Rüedi-Bettschen, Daniela; Williams, D. Keith; Hendrickson, Howard; Owens, S. Michael

    2014-01-01

    This study assessed clinical scenarios of continuing monoclonal antibody (mAb) treatment for (+)-methamphetamine (METH) addiction, and the implications of missing or discontinuing this therapy. We hypothesized that chronic anti-METH mAb7F9 (METH KD = 9 nM) treatment of rats could significantly decrease METH-induced behaviors; even with repeated METH challenges, use of METH doses in excess of mAb binding sites, and after discontinuing mAb treatment which results in a 10-fold reduction in mAb7F9 serum concentrations. Male Sprague Dawley rats (n=6/group) were treated with i.v. saline or a loading dose of mAb7F9 to achieve instant steady-state conditions followed by two weekly (141 mg/kg) doses ending on day 14. METH (0.56 mg/kg) was administered four hours and three days after each saline or mAb7F9 treatment, and on day 21. This produced locomotion and rearing behavior that lasted about 120 min in control rats. In mAb7F9 treated rats, METH-induced distance traveled was significantly reduced from 60–120 min (P<0.05) on days 0–21 and rearing was significantly reduced from 60–120 min on days 0–17. METH serum concentrations determined 5 hrs after METH dosing was significantly increased in mAb7F9-treated rats after all METH challenges. On days 24 and 28 (the final day), the rats were administered a 3-fold higher METH dose (1.68 mg/kg). MAb7F9 treated rats showed a substantially earlier termination of the METH-induced locomotion on both days, even though the METH dose exceeded mAb7F9’s binding capacity. METH brain concentrations determined 5 hrs after METH on day 28 were also significantly decreased in mAb7F9-treated rats. In conclusion, over one month, mAb7F9 significantly and continuously bound METH and reduced METH-induced locomotor effects even after discontinuation of mAb treatment and challenge with higher METH doses. PMID:25252196

  17. Use of Quantitative Fluorescent Polymerase Chain Reaction (QF PCR) in Prenatal Diagnostic of Fetal Aneuploidies in a 17 Month Period in Parallel with Karyotyping

    PubMed Central

    Konjhodzic, Rijad; Dervovic, Edina; Kurtovic-Basic, Ilvana; Stomornjak-Vukadin, Meliha; Muhic, Adis; Baljevic, Sumeja; Pirnat-Gegic, Aida; Basic, Ejub; Bilalovic, Nurija

    2014-01-01

    Introduction: QF PCR has recently entered diagnostic practice as a possible way to bypass culturing of the fetal cells, as well as to provide a rapid response following amniocentesis. Material and methods: The effective value of the QF PCR remains a much debated issue, positions ranging from that it makes classic kayotyping obsolete except in special occasions, to that it is no more than a guideline for a mandatory karyotype. Current practices of the gynecology specialists generates samples in such fashion that kariotyping of samples quickly falls behind to the point of obsoleteness, because, by the time a karyotype has been finished, a window of opportunity for termination of pregnancy has closed. Results: QF PCR provides a rapid response alternative, but it is necessary to establish its reproducibility, as well as an algorithm of its use along classic kariotyping. This study contains samples processed in a period from August 1, 2012 to December 31 2013 in both QF PCR and classic karyotype. Object of this study was compare results obtained by two methods, and establish confidence interval of the QF PCR testing. Overall, 661 amniotic fluid samples were processed and typed with QF PCR, out of which 221 were done in parallel with karyiotyping, as an confirmation of results. PMID:24825930

  18. Outcome of a second patch test reading of TRUE Tests® on D6/7.

    PubMed

    Madsen, Jakob Torp; Andersen, Klaus Ejner

    2013-02-01

    Background. Two readings of patch test reactions are recommended. Objectives. To evaluate the outcome of a second patch test reading of TRUE Test® allergens on D6/7 in relation to negative or doubtful reactions on D3/4. Methods. This was a retrospective investigation of patch test data from January 1992 to October 2011 from consecutive eczema patients tested with the TRUE Test® panels. Results. In the period of nearly 20 years, a total of 9997 patients were tested. The total number of positive reactions to the 29 allergens was 6509; 4.4% were positive on D6/7 and negative on D3/4; and 9.1% were positive on D6/7 after a doubtful (?+) reaction on D3/4. Neomycin was the most frequent allergen giving delayed positive reactions (57%), followed by budesonide (42%) and hydrocortisone-17-butyrate (31%). Conclusion. A total of 4.4% of positive TRUE Test® reactions would be missed, and 9.1% might be missed, if only one reading was performed on D3/4. The results emphasize that many doubtful reactions at D3/4 may develop into positive reactions at a later reading. This may have important implications for evaluation of the clinical relevance of the test result. PMID:23289880

  19. Comparison of 37 months global net radiation flux derived from PICARD-BOS over the same period observations of CERES and ARGO

    NASA Astrophysics Data System (ADS)

    Zhu, Ping; Wild, Martin

    2016-04-01

    The absolute level of the global net radiation flux (NRF) is fixed at the level of [0.5-1.0] Wm-2 based on the ocean heat content measurements [1]. The space derived global NRF is at the same order of magnitude than the ocean [2]. Considering the atmosphere has a negligible effects on the global NRF determination, the surface global NRF is consistent with the values determined from space [3]. Instead of studying the absolute level of the global NRF, we focus on the interannual variation of global net radiation flux, which were derived from the PICARD-BOS experiment and its comparison with values over the same period but obtained from the NASA-CERES system and inferred from the ocean heat content survey by ARGO network. [1] Allan, Richard P., Chunlei Liu, Norman G. Loeb, Matthew D. Palmer, Malcolm Roberts, Doug Smith, and Pier-Luigi Vidale (2014), Changes in global net radiative imbalance 1985-2012, Geophysical Research Letters, 41 (no.15), 5588-5597. [2] Loeb, Norman G., John M. Lyman, Gregory C. Johnson, Richard P. Allan, David R. Doelling, Takmeng Wong, Brian J. Soden, and Graeme L. Stephens (2012), Observed changes in top-of-the-atmosphere radiation and upper-ocean heating consistent within uncertainty, Nature Geoscience, 5 (no.2), 110-113. [3] Wild, Martin, Doris Folini, Maria Z. Hakuba, Christoph Schar, Sonia I. Seneviratne, Seiji Kato, David Rutan, Christof Ammann, Eric F. Wood, and Gert Konig-Langlo (2015), the energy balance over land and oceans: an assessment based on direct observations and CMIP5 climate models, Climate Dynamics, 44 (no.11-12), 3393-3429.

  20. Biotransformations of 6',7'-dihydroxybergamottin and 6',7'-epoxybergamottin by the citrus-pathogenic fungi diminish cytochrome P450 3A4 inhibitory activity

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Penicillium digitatum, as well as five other citrus pathogenic species, (P. ulaiense Link, Geotrichum citri Link, Botrytis cinerea P. Micheli ex Pers., Lasiodiplodia theobromae (Pat.)Griffon & Maubl. and Phomopsis citri (teleomorph Diaporthe citri)) was observed to convert 6',7'-epoxybergamottin (1)...

  1. Rare-earth plasma extreme ultraviolet sources at 6.5-6.7 nm

    SciTech Connect

    Otsuka, Takamitsu; Higashiguchi, Takeshi; Yugami, Noboru; Yatagai, Toyohiko; Kilbane, Deirdre; White, John; Dunne, Padraig; O'Sullivan, Gerry; Jiang, Weihua; Endo, Akira

    2010-09-13

    We have demonstrated a laser-produced plasma extreme ultraviolet source operating in the 6.5-6.7 nm region based on rare-earth targets of Gd and Tb coupled with a Mo/B{sub 4}C multilayer mirror. Multiply charged ions produce strong resonance emission lines, which combine to yield an intense unresolved transition array. The spectra of these resonant lines around 6.7 nm (in-band: 6.7 nm {+-}1%) suggest that the in-band emission increases with increased plasma volume by suppressing the plasma hydrodynamic expansion loss at an electron temperature of about 50 eV, resulting in maximized emission.

  2. The Medicina survey of methanol masers at 6.7 GHz

    NASA Astrophysics Data System (ADS)

    Slysh, V. I.; Val'tts, I. E.; Kalenskii, S. V.; Voronkov, M. A.; Palagi, F.; Tofani, G.; Catarzi, M.

    1999-01-01

    A survey of Class II methanol masers at 6.7 GHz was made in the Northern hemisphere with the 32-m Medicina radio telescope. 42 objects were detected, 20 of them are new detections at 6.7 GHz. Our results show that the detection rate of 6.7 GHz masers toward the inner part of the Galaxy is higher than in other directions. It is confirmed that most of the methanol masers are associated with faint compact HII regions. The 6.7 GHz methanol masers show large velocity dispersion and large velocity offset from the velocity of parent molecular clouds. Table 2 is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/Abstract.html

  3. Characterization of the proton beam at the output of the 6.7MeV LEDA RFQ.

    SciTech Connect

    Allen, C. K.; Colestock, P. L. ,; Gilpatrick, J. D.; Lysenko, W. P.; Rybarcyk, L. J.; Schneider, J. D.; Sheffield, R. L.; Smith, H. V.; Wangler, Thomas P.,; Crandall, K. R.; Chan, D.; Garnett, R. W.; Schulze, M. E.

    2001-01-01

    The present configuration of the Low-Energy Demonstration Accelerator (LEDA) consists of a 75-keV proton injector, a 6.7-MeV 350-MHz cw radio-frequency quadrupole (RFQ) with associated high-power and lowlevel rf systems, a 52-magnet periodic lattice followed by a short high-energy beam transport (HEBT) and highpower (670-kW cw) beam stop. The rms beam emittance was measured prior to the installation of the 52-magnet lattice, based on wire-scanner measurements of the beam profile at a single location in the HEBT. New measurements with additional diagnostic hardware have been performed to determine the rms transverse beam properties of the beam at the output of the 6.7-MeV LEDA RFQ. The 52-magnet periodic lattice also includes ten beam position monitors (BPMs) evenly spaced in pairs of two. The BPMs provide a measure of the bunched beam current that exhibits nulls at different locations in the lattice. Model predictions of the locations of the nulls and the strength of the bunched beam current are made to determine what information this data can provide regarding the longitudinal beam emittance.

  4. Origin of the Galactic Disk 6.7 kev Line Emission

    NASA Technical Reports Server (NTRS)

    Churchwell, Ed

    1997-01-01

    The goal of this program was to determine if the extended FeXXV 6.7 kev line emission might possibly be produced and confined by the hot wind-shocked bubbles to accompany UC HII regions. The main result of this study are: (1) FeXXV is detected in the W3 complex, but at a level that could only explain a small fraction of the galactic disk emission if all UC HII regions emit at about the same intensity as the W3 complex; (2) Two X-ray sources are detected in W3. W3-X 1 coincides with the radio image of this region, but W3-X2 has no radio, optical, or infrared counterpart; (3) There is no evidence for variability of W3-X1 during the period of observations (approx, 40,000 sec); (4) The X-ray spectrum of W3-X1 has no emission shortward of 1 kev, it peaks at approx. 2 kev and show significant emission out to approx. 6 kev. No individual lines are resolved. There is currently no generally accepted theory for extended hard X-ray emission in HII regions. Perhaps the most significant discovery of this program has been the detection of extended hard X-rays and the realization that some entirely new processes must be invoked to understand this; and (5)A minimum (chi)(sup 2) fit of the spectrum implies a H absorbing column of N(sub H) approx, equals to 2.1 x 10(exp 22)/ cm, a temperature of the emitting plasma of 7 x 10(exp 7) K, and a luminosity of approx. equal to 10(33)erg/s.

  5. REO Monthly

    SciTech Connect

    Walker, Howard Andrew

    2010-12-31

    A spreadsheet written in Microsoft Excel that evaluates combinations of renewable energy technologies at a site and identifies the combination that minimizes life cycle cost. Constraints on the optimization such as percent of energy from renewable, available land area; available investment capital, etc make the optimization more useful. Inputs to the model include building location, number of square feet and floors; monthly energy use and cost for electric and any other fuels. Outputs include size of each RE technology total investment, utility costs, O&M costs; percent renewable; life cycle cost; rate of return; CO2 savings.

  6. REO Monthly

    2010-12-31

    A spreadsheet written in Microsoft Excel that evaluates combinations of renewable energy technologies at a site and identifies the combination that minimizes life cycle cost. Constraints on the optimization such as percent of energy from renewable, available land area; available investment capital, etc make the optimization more useful. Inputs to the model include building location, number of square feet and floors; monthly energy use and cost for electric and any other fuels. Outputs include sizemore » of each RE technology total investment, utility costs, O&M costs; percent renewable; life cycle cost; rate of return; CO2 savings.« less

  7. AMMONIA AND CO OBSERVATIONS TOWARD LOW-LUMINOSITY 6.7 GHz METHANOL MASERS

    SciTech Connect

    Wu, Y. W.; Xu, Y.; Yang, J.; Zhang, S. B.; Pandian, J. D.; Henkel, C.; Menten, K. M.

    2010-09-01

    To investigate whether distinctions exist between low- and high-luminosity Class II 6.7 GHz methanol masers, we have undertaken multi-line mapping observations of various molecular lines, including the NH{sub 3} (1,1), (2,2), (3,3), (4,4), and {sup 12}CO (1-0) transitions, toward a sample of nine low-luminosity 6.7 GHz masers and {sup 12}CO (1-0) observations toward a sample of eight high-luminosity 6.7 GHz masers, for which we already had NH{sub 3} spectral line data. Emission in the NH{sub 3} (1,1), (2,2), and (3,3) transitions was detected in eight out of nine low-luminosity maser sources, in which 14 cores were identified. We derive densities, column densities, temperatures, core sizes, and masses of both low- and high-luminosity maser regions. A comparative analysis of the physical quantities reveals marked distinctions between the low-luminosity and high-luminosity groups: in general, cores associated with high-luminosity 6.7 GHz masers are larger and more massive than those traced by low-luminosity 6.7 GHz masers; regions traced by the high-luminosity masers have larger column densities but lower densities than those of the low-luminosity maser regions. Further, strong correlations between 6.7 GHz maser luminosity and NH{sub 3} (1,1) and (2,2) line widths are found, indicating that internal motions in high-luminosity maser regions are more energetic than those in low-luminosity maser regions. A {sup 12}CO (1-0) outflow analysis also shows distinctions in that outflows associated with high-luminosity masers have wider line wings and larger sizes than those associated with low-luminosity masers.

  8. The Association between Birth Weight and Gestational Age and Asthma in 6-7- and 13-14-Year-Old Children.

    PubMed

    Raheleh, Zamani; Ahmad, Alikhani; Abtin, Heydarzadeh; Roghaye, Zare; Sara, Hashemain; Siavash, Rahimi

    2016-01-01

    Background. Previous studies that assessed the role of birth weight and gestational age in the risk of asthma have been conflicting. Objectives. To examine the association between birth weight and gestational age and symptoms of asthma. Patients and Methods. Subjects were 6656 school children of ages 6-7 and 13-14 years from urban districts of Mazandaran, Iran. ISAAC questionnaires were used. Results. There was an increased risk of "wheeze ever" in both age groups with birth weight under 2.5 kg and in all subgroups of low birth weight (LBW). Birth weight more than 3.5 kg was associated with lower risk of "severe asthma" in age group 6-7 years. With respect to gestational age, higher risks of "wheeze ever," "asthma ever," and "night cough in the past 12 months" were found in age group 13-14 years born before 37 weeks and the risk of "severe asthma" was higher in younger group (6-7 years). A lower risk of "asthma ever" was also found in 6-7-year-old children and 13-14-year-old girls who were born after 40 weeks. Conclusions. This study showed that there is a direct relation between "wheeze ever" and LBW and an inverse relation between risk of "severe asthma" and birth weight more than 3.5 kg. PMID:27379196

  9. Characteristics and capacities of the NASA Lewis Research Center high precision 6.7- by 6.7-m planar near-field scanner

    NASA Technical Reports Server (NTRS)

    Sharp, G. R.; Zakrajsek, R. J.; Kunath, R. R.; Raquet, C. A.; Alexovich, R. E.

    1984-01-01

    A very precise 6.7- by 6.7-m planar near-field scanner has recently become operational at the NASA Lewis Research Center. The scanner acquires amplitude and phase data at discrete points over a vertical rectangular grid. During the design phase for this scanner, special emphasis was given to the dimensional stability of the structures and the ease of adjustment of the rails that determine the accuracy of the scan plane. A laser measurement system is used for rail alignment and probe positioning. This has resulted in very repeatable horizontal and vertical motion of the probe cart and hence precise positioning in the plane described by the probe tip. The resulting accuracy will support near-field measurements at 60 GHz without corrections. Subsystem design including laser, electronic and mechanical and their performance is described. Summary data are presented on the scan plane flatness and environmental temperature stability. Representative near-field data and calculated far-field test results are presented. Prospective scanner improvements to increase test capability are also discussed.

  10. Antileishmanial activity of essential oil and 6,7-dehydroroyleanone isolated from Tetradenia riparia.

    PubMed

    Demarchi, Izabel Galhardo; Thomazella, Mateus Vailant; de Souza Terron, Mariana; Lopes, Lilian; Gazim, Zilda Cristiani; Cortez, Diógenes Aparício Garcia; Donatti, Lucélia; Aristides, Sandra Mara Alessi; Silveira, Thaís Gomes Verzignassi; Lonardoni, Maria Valdrinez Campana

    2015-10-01

    Tetradenia riparia plant is used as a traditional medicine in Africa for the treatment of inflammatory and infectious diseases as like parasitic. Therapy for leishmaniasis caused by Leishmania (Leishmania) amazonensis specie often fails, and the conventional drugs are toxic, expensive, require a long period of treatment, and adverse effects are common. The alternative therapies using natural products are inexpensive and have few or any adverse reaction. These reasons are sufficient to investigate the new natural therapeutic for leishmaniasis. We evaluated the potential of the essential oil (TrEO) and 6,7-dehydroroyleanone (TrROY) isolated from T. riparia on L. (L.) amazonensis promastigote and amastigote forms, cytotoxicity on human erythrocytes and murine macrophages, nitric production and inducible nitric oxide synthase (iNOS) mRNA expression. TrEO was the most effective to promote the Leishmania promastigote death. After 72 h incubation, the lethal dose of TrEO and TrROY that promoted 50% Leishmania death (LD50) were 0.8 μg/mL and 3 μg/mL, respectively. TrEO and TrROY were not cytotoxic to human erythrocytes, but TrROY was toxic to murine macrophages resulting in a low selectivity index. The transmission electronic microscopy showed that TrEO (0.03 μg/mL) was able to modify the promastigote ultrastructures suggesting autophagy as chromatin condensation, blebbing, membranous profiles and nuclear fragmentation. Infected-macrophages treated with TrEO (0.03 μg/mL) or TrROY (10 μg/mL) had an infection index decreased in 65 and 48%. TrEO did not induce iNOS mRNA expression or nitrite production in macrophages infected with Leishmania. TrROY and mainly TrEO promoted the Leishmania death, and TrROY showed loss toxicity to erythrocytes cells. Other compounds derived from T. riparia and the essential oil could be explored to develop a new alternative treatment for leishmaniasis. PMID:26116864

  11. The Magnitude 6.7 Northridge, California, Earthquake of January 17, 1994

    NASA Technical Reports Server (NTRS)

    Donnellan, A.

    1994-01-01

    The most damaging earthquake in the United States since 1906 struck northern Los Angeles on January 17.1994. The magnitude 6.7 Northridge earthquake produced a maximum of more than 3 meters of reverse (up-dip) slip on a south-dipping thrust fault rooted under the San Fernando Valley and projecting north under the Santa Susana Mountains.

  12. Magnetic field in the Earth's outer magnetosphere: Prognoz-6, -7 data

    NASA Astrophysics Data System (ADS)

    Antonova, A. E.; Eroshenko, E. G.; Styazhkin, V. A.

    1984-09-01

    The Prognoz-6,7 measurements of magnetic field at 8-25 RE in the outer magnetosphere and in the adjacent regions from 1977 to 1979 carried out within the IMS program are presented. The experimental data are compared with the magnetospheric model predictions.

  13. Analysis of the GOES 6.7 micrometer channel observations during FIRE 2

    NASA Technical Reports Server (NTRS)

    Soden, B. J.; Ackerman, S. A.; Starr, David

    1993-01-01

    Clouds form in moist environments. FIRE Phase II Cirrus Implementation Plan (August, 1990) noted the need for mesoscale measurements of upper tropospheric water vapor content. These measurements are needed for initializing and verifying numerical weather prediction models and for describing the environment in which cirrus clouds develop and dissipate. Various instruments where deployed to measure the water vapor amounts of the upper troposphere during FIRE II (e.g. Raman lidar, CLASS sonds and new cryogenic frost hygrometer on-board aircraft). The formation, maintenance and dissipation of cirrus clouds involve the time variation of the water budget of the upper troposphere. The GOES 6.7 mu m radiance observations are sensitive to the upper tropospheric relative humidity, and therefore proved extremely valuable in planning aircraft missions during the field phase of FIRE II. Warm 6.7 mu m equivalent black body temperatures indicate a relatively dry upper troposphere and were associated with regions generally free of cirrus clouds. Regions that were colder, implying more moisture was available may or may not have had cirrus clouds present. Animation of a time sequence of 6.7 mu m images was particularly useful in planning various FIRE missions. The 6.7 mu m observations can also be very valuable in the verification of model simulations and describing the upper tropospheric synoptic conditions. A quantitative analysis of the 6.7 mu m measurement is required to successfully incorporate these satellite observations into describing the upper tropospheric water vapor budget. Recently, Soden and Bretherton (1993) have proposed a method of deriving an upper tropospheric humidity based on observations from the GOES 6.7 mu m observations. The method is summarized in the next section. In their paper they compare their retrieval method to radiance simulations. Observations were also compared to ECMWF model output to assess the model performance. The FIRE experiment provides a

  14. Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes) relative to alpha-quartz following a single 6h inhalation exposure of rats and a 3 months post-exposure period.

    PubMed

    Ellinger-Ziegelbauer, Heidrun; Pauluhn, Jürgen

    2009-12-21

    Manufactured multi-walled carbon nanotubes (MWCNT) have attracted a great deal of attention due to their unique structural, chemical, and physical characteristics. This study utilized a 1x 6h inhalation exposure protocol followed by a 3 months post-exposure period. Wistar rats were nose-only exposed to 11 and 241 mg/m(3) MWCNT (Baytubes) of respirable, solid aerosol. MWCNT depleted of residual metals (depletion from 0.53% to 0.12% Co) were compared at 11 mg/m(3). Rats similarly exposed to air and alpha-quartz (248 mg/m(3)) served as negative and positive controls, respectively. Pulmonary response was characterized by bronchoalveolar lavage (BAL), lung histopathology, organ burden determinations, and gene expression analyses of lung homogenates with emphasis on extracellular matrix components. This acute inhalation exposure protocol was suitable to characterize and distinguish acute deposition-related effects from the long-term sequelae of retained MWCNT. Subtle differences in acute pulmonary toxic potency due to differences in metal contaminations could be revealed by this protocol. Consistent with the long retention halftime of poorly soluble particles, even short-term inhalation studies may require post-exposure periods of at least 3 months to reveal MWCNT-specific dispositional and toxicological characteristics relative to alpha-quartz. Distinct differences in the time course of pulmonary inflammation of MWCNT and alpha-quartz could be demonstrated. Transcriptomics proved to be a useful tool to analyze the etiopathology of collagen detected by BAL and histopathology. In summary, the pulmonary inflammogenicity following exposure to MWCNT was concentration-dependent with evidence of regression over time. Conversely, alpha-quartz resulted in progressive changes over time. The time course of pulmonary inflammation associated with retained MWCNT was independent on the concentration of residual cobalt. This supports the conclusion that the predominant response to

  15. Antioxidant enzyme activities and lipid peroxidation in earthworm Eisenia fetida exposed to 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-γ-2-benzopyran.

    PubMed

    Liu, Shuo; Zhou, Qixing; Chen, Chun

    2012-08-01

    Polycyclic musks have been indicated to cause lethal and sublethal effects on exposed biota. However, knowledge about the effect of polycyclic musks on the antioxidant defense system in earthworms is vague. In this work, the activities of antioxidant enzymes, including superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and malondialdehyde (MDA) exposed to 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-γ-2-benzopyran (HHCB) were systematically investigated. The investigation shows that their activities are closely related to the exposed dose and time of HHCB. For SOD and CAT, the activities increased monotonically with increased exposed dose of HHCB, which indicates a dose-dependent change pattern. POD exhibited its peak activity in 0.0157 μg cm(-2) HHCB treatment and decreased at higher concentrations. These two changing patterns were complementary, which reveals the cooperation of enzymes in response to oxidative stress. MDA content in earthworms was basically unaffected with a 1-day exposure and significantly increased after 2-day and 3-day exposures, correlating with changes in the activities of SOD and CAT when the concentration of HHCB was high. It was also found that the sensitivity of Eisenia fetida to HHCB increased over time. These results may support the theoretical hypothesis that oxidative stress is an important component for the response of earthworms to the toxicity of HHCB in environment. Among the studied enzymes, SOD and CAT appeared to be the most responsive biomarkers of oxidative stress caused by HHCB. © 2010 Wiley Periodicals, Inc. Environ Toxicol, 2012. PMID:22764077

  16. Physical Conditions around 6.7 GHz Methanol Masers. I. Ammonia

    NASA Astrophysics Data System (ADS)

    Pandian, J. D.; Wyrowski, F.; Menten, K. M.

    2012-07-01

    Methanol masers at 6.7 GHz are known to be tracers of high-mass star formation in our Galaxy. In this paper, we study the large-scale physical conditions in the star-forming clumps/cores associated with 6.7 GHz methanol masers using observations of the (1, 1), (2, 2), and (3, 3) inversion transitions of ammonia with the Effelsberg telescope. The gas kinetic temperature is found to be higher than in infrared dark clouds, highlighting the relatively evolved nature of the maser sources. Other than a weak correlation between maser luminosity and the ammonia line width, we do not find any differences between low- and high-luminosity methanol masers.

  17. E. coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase†

    PubMed Central

    McCarty, Reid M.; Somogyi, Árpád; Bandarian, Vahe

    2009-01-01

    To elucidate the early steps required during biosynthesis of a broad class of 7-deazapurine containing natural products, we have studied the reaction catalyzed by Escherichia coli QueD, a 6-pyruvoyl-5,6,7,8-tetrahydropterin synthase (PTPS) homolog possibly involved in queuosine biosynthesis. While mammalian PTPS homologs convert 7,8-dihydroneopterin triphosphate (H2NTP) to 6-pyruvoyltetrahydropterin (PPH4) in biopterin biosynthesis, E. coli QueD catalyzes the conversion of H2NTP to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4). E. coli QueD can also convert PPH4 and sepiapterin to CPH4, allowing a mechanism to be proposed. PMID:19231875

  18. 6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 Integrase Inhibitors

    PubMed Central

    Zhao, Xue Zhi; Maddali, Kasthuraiah; Smith, Steven J.; Métifiot, Mathieu; Johnson, Barry C.; Marchand, Christophe; Hughes, Stephen H.; Pommier, Yves; Burke, Terrence R.

    2012-01-01

    Although an extensive body of scientific and patent literature exists describing the development of HIV-1 integrase (IN) inhibitors, Merck’s raltegravir and Gilead’s elvitegravir remain the only IN inhibitors FDA-approved for the treatment of AIDS. The emergence of raltegravir-resistant strains of HIV-1 containing mutated forms of IN underlies the need for continued efforts to enhance the efficacy of IN inhibitors against resistant mutants. We have previously described bicyclic 6,7-dihydroxyoxoisoindolin-1-ones that show good IN inhibitory potency. This report describes the effects of introducing substituents into the 4- and 5- positions of the parent 6,7-dihydroxyoxoisoindolin-1-one platform. We have developed several sulfonamide-containing analogs that enhance potency in cell-based HIV assays by more than two orders-of-magnitude and we describe several compounds that are more potent than raltegravir against the clinically relevant Y143R IN mutant. PMID:23149229

  19. 6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.

    PubMed

    Zhao, Xue Zhi; Maddali, Kasthuraiah; Smith, Steven J; Métifiot, Mathieu; Johnson, Barry C; Marchand, Christophe; Hughes, Stephen H; Pommier, Yves; Burke, Terrence R

    2012-12-15

    Although an extensive body of scientific and patent literature exists describing the development of HIV-1 integrase (IN) inhibitors, Merck's raltegravir and Gilead's elvitegravir remain the only IN inhibitors FDA-approved for the treatment of AIDS. The emergence of raltegravir-resistant strains of HIV-1 containing mutated forms of IN underlies the need for continued efforts to enhance the efficacy of IN inhibitors against resistant mutants. We have previously described bicyclic 6,7-dihydroxyoxoisoindolin-1-ones that show good IN inhibitory potency. This report describes the effects of introducing substituents into the 4- and 5-positions of the parent 6,7-dihydroxyoxoisoindolin-1-one platform. We have developed several sulfonamide-containing analogs that enhance potency in cell-based HIV assays by more than two orders-of-magnitude and we describe several compounds that are more potent than raltegravir against the clinically relevant Y143R IN mutant. PMID:23149229

  20. Coupled channel effect in elastic scattering and fusion for 6,7Li+28Si

    NASA Astrophysics Data System (ADS)

    Sinha, Mandira; Roy, Subinit; Basu, P.; Majumdar, H.; Santra, S.; Parkar, V. V.; Golda, K. S.; Kailas, S.

    2011-10-01

    The fusion excitation and elastic angular distribution were measured for 6,7Li+28Si from below to above Coulomb barrier (≤ 3Vb) energies. The barrier distribution derived from the fusion data was found to be broad and asymmetric at the sub-barrier region, compared to 1D BPM estimation. Effect of rotational coupling on fusion was found to be not so dominant. Phenomenological optical potential parameters, with surface and volume type imaginary potentials, were obtained from f tting of elastic scattering data and energy dependence of real and imaginary surface strengths were investigated around the barrier. CDCC calculations considering only breakup of projectile were performed for 6,7Li+28Si with the elastic scattering data, using the code FRESCO. The effects of breakup of projectile on elastic cross section do not agree with the energy dependence of real and imaginary strength with volume type imaginary potential around the barrier.

  1. Electromyographic responses to emotional facial expressions in 6-7 year olds with autism spectrum disorders.

    PubMed

    Deschamps, P K H; Coppes, L; Kenemans, J L; Schutter, D J L G; Matthys, W

    2015-02-01

    This study aimed to examine facial mimicry in 6-7 year old children with autism spectrum disorder (ASD) and to explore whether facial mimicry was related to the severity of impairment in social responsiveness. Facial electromyographic activity in response to angry, fearful, sad and happy facial expressions was recorded in twenty 6-7 year old children with ASD and twenty-seven typically developing children. Even though results did not show differences in facial mimicry between children with ASD and typically developing children, impairment in social responsiveness was significantly associated with reduced fear mimicry in children with ASD. These findings demonstrate normal mimicry in children with ASD as compared to healthy controls, but that in children with ASD the degree of impairments in social responsiveness may be associated with reduced sensitivity to distress signals. PMID:23888357

  2. Relationships between 6.7 micrometer imagery and radiosonde-derived parameters

    NASA Technical Reports Server (NTRS)

    Stewart, Michael R.; Fuelberg, Henry E.

    1986-01-01

    The relationships between water vapor images and various thermodynamic and kinematic patterns derived from ground-based data obtained on March 6-7, 1982 are investigated. The synoptic-scale characteristics of the observed image streaks are studied. Water vapor budgets were calculated from sonde data. Variations in black body temperatures are analyzed using water vapor budgets. The data reveal that the observed warm image streaks are caused by subsidence and horizontal flux divergence of vapor.

  3. Elevated Temperature and 6-7 Year Outcome of Neonatal Encephalopathy

    PubMed Central

    Laptook, Abbot R.; McDonald, Scott A.; Shankaran, Seetha; Stephens, Bonnie E.; Vohr, Betty R.; Guillet, Ronnie; Higgins, Rosemary D.; Das, Abhik

    2013-01-01

    OBJECTIVE Determine if higher temperature after hypoxia-ischemia is associated with death or IQ < 70 at 6-7 yr among infants treated with intensive care without hypothermia. DESIGN/METHODS Control infants (non-cooled, n=106) of the NICHD Neonatal Research Network hypothermia trial had serial esophageal and skin temperatures over 72hrs. Each infant's temperature was ranked to derive an average of the upper and lower quartile, and median of each site. Temperatures were used in logistic regressions to determine adjusted associations with death or IQ < 70 at 6-7yrs. Secondary outcomes were death, IQ < 70, and moderate/severe CP. IQ and motor function were assessed with Wechsler Scales for Children and Gross Motor Function Classification System. Results are odds ratio (OR, per °C increment within the quartile or median) and 95% confidence interval (CI). RESULTS Primary outcome was available for 89 infants. At 6-7yrs death or IQ < 70 occurred in 54 infants (37 deaths, 17 survivors with IQ < 70) and moderate/severe CP in 15 infants. Death or IQ < 70 was associated with the upper quartile average of esophageal (OR 7.3, 95% CI 2.0-26.3) and skin temperature (OR 3.5, 95% 1.2-10.4). CP was associated with the upper quartile average of esophageal (OR 12.5, 95% CI 1.02-155) and skin temperature (OR 10.3, 95% 1.3-80.2). CONCLUSIONS Among non-cooled infants of a randomized trial, elevated temperatures during the first post-natal days are associated with increase odds of a worse outcome at 6-7yrs. PMID:23595408

  4. [Measurements of PSA and of vitamin D: a period of 3-months of use of special forms based on the guidelines of the Haute autorité de santé shows a clear improvement of prescription behaviors].

    PubMed

    Watine, Joseph

    2015-01-01

    In France practice guidelines of the Haute Autorité de santé (HAS) are not implemented as often as they should. As a consequence resources are wasted that could be useful elsewhere. In Avril 2014 prescription-forms were introduced in our hospital for PSA and for vitamin-D. If those forms were not filled-in by the physicians, then PSA and vitamin-D were not measured any more by our laboratory. PSA was measured in only two circumstances: therapeutic follow-up of, or screening for, prostate cancer. Patients had to give their formal consent for being screened with PSA. Vitamin-D was measured in the only six circumstances recommended by the HAS. After a few months of use of these two forms we observe a sharp decrease in PSA, and even more so in vitamin D, measurements. Our prescription-forms' legitimacy is high because they are based on governmental guidelines. All the more since the values that are promoted in these guidelines clearly cover the four core principles of bioethics, that is beneficence, non-malevolence, respect for the patient's autonomy (particularly for PSA) and equity. Our results need to be confirmed over a longer period of time, and to be analysed in more detail, particularly regarding the way consent forms are filled-in by the patients. PMID:25847748

  5. Management of traumatic c6-7 spondyloptosis with cord compression.

    PubMed

    Choi, Man-Kyu; Jo, Dae-Jean; Kim, Min-Ki; Kim, Tae-Sung

    2014-05-01

    A case of total spondyloptosis of the cervical spine at C6-7 level with cord compression is described in a 51-year-old male. Because the bodies of C6 and 7 were tightly locked together, cervical traction failed. Then the patient was operated on by a posterior approach. Posterior stabilization and fusion were performed by C4-5 lateral mass and C7-T1 pedicle screw fixation and rod instrumentation with bridging both C4-5's rods to the C7-T1's extended ones. After C6 total laminectomy and foraminotomy, the C6 body was returned to its proper position. Secondly, anterior stabilization and fusion were performed by C6-7 discectomy with a screw-plate system. A postoperative lateral plain radiograph showed good realignment. In this case, we report the clinical presentation and discuss the surgical modalities of C6-7 total spondyloptosis and the failed close reduction. PMID:25132938

  6. COSMIC monthly progress report

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Activities of the Computer Software Management and Information Center (COSMIC) are summarized for the month of January 1994. Tables showing the current inventory of programs available from COSMIC are presented and program processing and evaluation activities are discussed. Marketing and customer service activities in this period are presented as is the progress report of NASTRAN maintenance and support. Tables of disseminations and budget summary conclude the report.

  7. Biosynthesis of riboflavin. Enzymatic formation of 6,7-dimethyl-8-ribityllumazine from pentose phosphates.

    PubMed

    Nielsen, P; Neuberger, G; Fujii, I; Bown, D H; Keller, P J; Floss, H G; Bacher, A

    1986-03-15

    The xylene ring of riboflavin originates by dismutation of the precursor, 6,7-dimethyl-8-ribityllumazine. The formation of the latter compound requires a 4-carbon unit as the precursor of carbon atoms 6 alpha, 6, 7, and 7 alpha of the pyrazine ring. The formation of riboflavin from GTP and ribose phosphate by cell extract from Candida guilliermondii has been observed by Logvinenko et al. (Logvinenko, E. M., Shavlovsky, G. M., Zakal'sky, A. E., and Zakhodylo, I. V. (1982) Biokhimiya 47, 931-936). We have studied this enzyme reaction in closer detail using carbohydrate phosphates as substrates and synthetic 5-amino-6-ribitylamino-2,4-(1H,3H)-pyrimidinedione or its 5'-phosphate as cosubstrates. Several pentose phosphates and pentulose phosphates can serve as substrate for the formation of riboflavin with similar efficiency. The reaction requires Mg2+. Various samples of ribulose phosphate labeled with 14C or 13C have been prepared and used as enzyme substrates. Radioactivity was efficiently incorporated into riboflavin from [1-14C]ribulose phosphate, [3,5-14C]ribulose phosphate, and [5-14C]ribulose phosphate, but not from [4-14C]ribulose phosphate. Label from [1-13C]ribose 5-phosphate was incorporated into C6 and C8 alpha of riboflavin. [2,3,5-13C]Ribose 5-phosphate yielded riboflavin containing two contiguously labeled segments of three carbon atoms, namely 5a, 9a, 9 and 8, 7, 7 alpha. 5-Amino-6-[1'-14C] ribitylamino-2,4 (1H,3H)-pyrimidinedione transferred radioactivity exclusively to the ribityl side chain of riboflavin in the enzymatic reaction. It follows that the 4-carbon unit used for the biosynthesis of 6,7-dimethyl-8-ribityllumazine consists of the pentose carbon atoms 1, 2, 3, and 5 in agreement with earlier in vivo studies. PMID:3949782

  8. Quantum Monte Carlo calculations of electroweak transition matrix elements in A=6,7 nuclei

    SciTech Connect

    Pervin, Muslema; Pieper, Steven C.; Wiringa, R. B.

    2007-12-15

    Green's function Monte Carlo (GFMC) calculations of magnetic dipole, electric quadrupole, Fermi, and Gamow-Teller transition matrix elements are reported for A=6,7 nuclei. The matrix elements are extrapolated from mixed estimates that bracket the relevant electroweak operator between variational Monte Carlo (VMC) and GFMC propagated wave functions. Because they are off-diagonal terms, two mixed estimates are required for each transition, with a VMC initial (final) state paired with a GFMC final (initial) state. The realistic Argonne v{sub 18} two-nucleon and Illinois-2 three-nucleon interactions are used to generate the nuclear states. In most cases we find good agreement with experimental data.

  9. Extreme ultraviolet source at 6.7 nm based on a low-density plasma

    SciTech Connect

    Higashiguchi, Takeshi; Yugami, Noboru; Otsuka, Takamitsu; Jiang, Weihua; Endo, Akira; Li Bowen; Kilbane, Deirdre; Dunne, Padraig; O'Sullivan, Gerry

    2011-11-07

    We demonstrate an efficient extreme ultraviolet (EUV) source for operation at {lambda} = 6.7 nm by optimizing the optical thickness of gadolinium (Gd) plasmas. Using low initial density Gd targets and dual laser pulse irradiation, we observed a maximum EUV conversion efficiency (CE) of 0.54% for 0.6% bandwidth (BW) (1.8% for 2% BW), which is 1.6 times larger than the 0.33% (0.6% BW) CE produced from a solid density target. Enhancement of the EUV CE by use of a low-density plasma is attributed to the reduction of self-absorption effects.

  10. Ligubenzocycloheptanone A, a Novel Tricyclic Butenolide with a 6/7/5 Skeleton from Ligusticum chuanxiong

    PubMed Central

    Han, Bing; Zhang, Xu; Feng, Zi-Ming; Jiang, Jian-Shuang; Li, Li; Yang, Ya-Nan; Zhang, Pei-Cheng

    2016-01-01

    Ligubenzocycloheptanone A (1), a novel tricyclic butenolide with a 6/7/5-membered ring skeleton, was isolated from the rhizome of Ligusticum chuanxiong. Its unusual structure was determined using UV, IR, HRESIMS, 1D and 2D NMR data, X-ray diffraction crystallography and by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. 1 possessed a benzocycloheptanone core featuring butyrolactone, which is rarely observed in nature. A possible biosynthetic pathway was proposed. Ligubenzocycloheptanone A showed strong radical scavenging activity with an IC50 value of 2.3 μM. PMID:27461841

  11. Ligubenzocycloheptanone A, a Novel Tricyclic Butenolide with a 6/7/5 Skeleton from Ligusticum chuanxiong

    NASA Astrophysics Data System (ADS)

    Han, Bing; Zhang, Xu; Feng, Zi-Ming; Jiang, Jian-Shuang; Li, Li; Yang, Ya-Nan; Zhang, Pei-Cheng

    2016-07-01

    Ligubenzocycloheptanone A (1), a novel tricyclic butenolide with a 6/7/5-membered ring skeleton, was isolated from the rhizome of Ligusticum chuanxiong. Its unusual structure was determined using UV, IR, HRESIMS, 1D and 2D NMR data, X-ray diffraction crystallography and by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. 1 possessed a benzocycloheptanone core featuring butyrolactone, which is rarely observed in nature. A possible biosynthetic pathway was proposed. Ligubenzocycloheptanone A showed strong radical scavenging activity with an IC50 value of 2.3 μM.

  12. High data-rate 6.7 GHz wireless ASIC transmitter for neural prostheses.

    PubMed

    Chow, Eric Y; Kahn, Adam; Irazoqui, Pedro P

    2007-01-01

    A high-frequency transmitter has been designed for high data-rate biomedical telemetry. Although high frequencies face greater attenuation, transcutaneous transmission was successfully tested and verified using a 3.76 mm thick sample of porcine skin. The structure transmits over 440 microW of power, consumes about 4.9 mA of current from a 1.8 V supply, and achieves a phase noise of -72 dBc/Hz at 100 KHz. The transmitter operates at around 6.7 GHz with a 50 MHz tuning range and is fully integrated on the CMOS IBM7RF 0.18 microm process. PMID:18003533

  13. Multifractal analysis of seismic electric signals observed prior a earthquake of M6.7

    NASA Astrophysics Data System (ADS)

    Ramírez-Rojas, Alejandro; Rebeca Moreno-Torres, Lucía

    2014-05-01

    In this work we studied the multifractal spectrum behavior calculated during the presence of a possible seismic electrical signal (SES). This signal was detected in a geolectrical time series registered prior a seism of M6.7 occurred on October 24, 1993 in México. We calculated the multifractal spectrum by using nonoverlapping windows of segments of 1 hour. Our results display the singularities spectrum calculated before, during and after the possible SES, showing important differences in some parameters like the width and maxima values, among others, in the spectra. Those observations suggest that the physical system has different dynamical features along the process and possibly as a precursor sign.

  14. Effect of breakup coupling on fusion for 6,7Li+24Mg systems

    NASA Astrophysics Data System (ADS)

    Pradhan, M. K.; Mukherjee, A.; Dasmahapatra, B.

    2015-01-01

    To study the effect of breakup coupling on fusion we have derived fusion cross sections in the framework of continuum discretised coupled channels (CDCC) method using the coupled channels code FRESCO for the systems 6,7Li+24Mg. The CDCC predicted fusion cross sections for the 7Li+24Mg system agree well with the experimental fusion data whereas for the 6Li+24Mg system the agreement is reasonable at below barrier energies. However, within the limits of the present work no definite conclusion could be obtained from the quality of agreement at above barrier energies for the 6Li+24Mg system.

  15. 6.7 GHz methanol masers: Properties, Associations and Tracers of Galactic Structure

    NASA Astrophysics Data System (ADS)

    Pandian, Jagadheep D.

    2007-01-01

    The 6.7 GHz transition of methanol is the strongest of methanol masers, and is the second strongest maser transition ever observed in the Milky Way. There is st rong theoretical and observational evidence that the masers trace an early phase of massive star formation. The lack of association of these masers with other astronomical objects such as low-mass young stellar objects (YSOs) and late type stars, and their high brightness temperatures makes them excellent tools to detect and study massive star formation across our Galaxy. The preponderance of massive stars along the spiral arms of galaxies also imply the potential utility of these methanol masers to study the spiral structure of our Galaxy. In this dissertation, we present a study of 6.7 GHz methanol masers and their properties based on the Arecibo Methanol Maser Galactic Plane Survey (AMGPS), a sensitive blind survey carried out with the Arecibo radio telescope. To carry out this study, we built a receiver for Arecibo that could process signals between 6 and 8 GHz. The high sensitivity of the cooled receiver and the large collecting area of Arecibo made AMGPS the most sensitive blind survey to date for 6.7 GHz methanol masers, and resulted in the detection of 86 methanol masers, 48 of which are new detections. The distribution of methanol masers as a function of Galactic latitude and the statistics of their multi-wavelength counterparts show our data to be consistent with the hypothesis of 6.7 GHz methanol masers being associated with massive YSOs. Using the detection statistics of AMGPS, we estimate the minimum number of methanol masers in the Galaxy to be 1125. The l-v diagram of the AMGPS sample shows the tangent point of the Carina-Sagittarius spiral arm to be around 49.6°, and suggests occurrence of massive star formation along the extension of the Crux-Scutum arm. A Gaussian component analysis of methanol masers shows the mean line-width to be 0.38 km s^{-1} which is more a factor of two larger than

  16. Short-Term Periodicities in Solar Indices

    NASA Astrophysics Data System (ADS)

    Kane, R. P.

    2005-03-01

    The purpose of the present communication is to identify the short-term (few tens of months) periodicities of several solar indices (sunspot number, Caii area and K index, Lyman α, 2800 MHz radio emission, coronal green-line index, solar magnetic field). The procedure used was: from the 3-month running means (3m) the 37-month running means (37m) were subtracted, and the factor (3m - 37m) was examined for several parameters. For solar indices, considerable fluctuations were seen during the ± 4 years around sunspot maxima of cycles 18-23, and virtually no fluctuations were seen in the ± 2 years around sunspot minima. The spacings between successive peaks were irregular but common for various solar indices. Assuming that there are stationary periodicities, a spectral analysis was carried out which indicated periodicities of months: 5.1 5.7, 6.2 7.0, 7.6 7.9, 8.9 9.6, 10.4 12.0, 12.8 13.4, 14.5 17.5, 22 25, 28 (QBO), 31 36 (QBO), 41 47 (QTO). The periodicities of 1.3 year (15.6 months) and 1.7 years (20.4 months) often mentioned in the literature were seen neither often nor prominently. Other periodicities occurred more often and more prominently. For the open magnetic flux estimated by Wang, Lean, and Sheeley (2000) and Wang and Sheeley (2002), it was noticed that the variations were radically different at different solar latitudes. The open flux for < 45∘ solar latitudes had variations very similar (parallel) to the sunspot cycle, while open flux for > 45∘ solar latitudes had variations anti-parallel to the sunspot cycle. The open fluxes, interplanetary magnetic field and cosmic rays, all showed periodicities similar to those of solar indices. Many peaks (but not all) matched, indicating that the open flux for < 45∘ solar latitudes was at least partially an adequate carrier of the solar characteristics to the interplanetary space and thence for galactic cosmic ray modulation.

  17. Electromyographic Responses to Emotional Facial Expressions in 6-7 Year Olds with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Deschamps, P. K. H.; Coppes, L.; Kenemans, J. L.; Schutter, D. J. L. G.; Matthys, W.

    2015-01-01

    This study aimed to examine facial mimicry in 6-7 year old children with autism spectrum disorder (ASD) and to explore whether facial mimicry was related to the severity of impairment in social responsiveness. Facial electromyographic activity in response to angry, fearful, sad and happy facial expressions was recorded in twenty 6-7 year old…

  18. 42 CFR 408.20 - Monthly premiums.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Monthly premiums. 408.20 Section 408.20 Public... PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE Amount of Monthly Premiums § 408.20 Monthly premiums. (a) Statutory provisions. (1) The law established a monthly premium of $3 for the initial period of the...

  19. 42 CFR 408.20 - Monthly premiums.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Monthly premiums. 408.20 Section 408.20 Public... PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE Amount of Monthly Premiums § 408.20 Monthly premiums. (a) Statutory provisions. (1) The law established a monthly premium of $3 for the initial period of the...

  20. 42 CFR 408.20 - Monthly premiums.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Monthly premiums. 408.20 Section 408.20 Public... PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE Amount of Monthly Premiums § 408.20 Monthly premiums. (a) Statutory provisions. (1) The law established a monthly premium of $3 for the initial period of the...

  1. 42 CFR 408.20 - Monthly premiums.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Monthly premiums. 408.20 Section 408.20 Public... PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE Amount of Monthly Premiums § 408.20 Monthly premiums. (a) Statutory provisions. (1) The law established a monthly premium of $3 for the initial period of the...

  2. 42 CFR 408.20 - Monthly premiums.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Monthly premiums. 408.20 Section 408.20 Public... PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE Amount of Monthly Premiums § 408.20 Monthly premiums. (a) Statutory provisions. (1) The law established a monthly premium of $3 for the initial period of the...

  3. 6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2.

    PubMed

    Lee, Dong Eun; Lee, Ki Won; Jung, Sung Keun; Lee, Eun Jung; Hwang, Jung A; Lim, Tae-Gyu; Kim, Bo Yeon; Bode, Ann M; Lee, Hyong Joo; Dong, Zigang

    2011-04-01

    Colon cancer is a common epithelial malignancies worldwide. Epidemiologic evidence has shown that nutrition and dietary components are important environmental factors involved in the development of this disease. We investigated the biological activity of 6,7,4'-trihydroxyisoflavone (6,7,4'-THIF, a metabolite of daidzein) in in vitro and in vivo models of human colon cancer. 6,7,4'-THIF suppressed anchorage-dependent and -independent growth of HCT-116 and DLD1 human colon cancer cells more effectively than daidzein. In addition, 6,7,4'-THIF induced cell cycle arrest at the S and G2/M phases in HCT-116 human colon cancer cells. Western blot analysis revealed that 6,7,4'-THIF effectively suppressed the expression of cyclin-dependent kinase (CDK) 2, but had no effect on other S- or G2/M-phase regulatory proteins such as cyclin A, cyclin B1 or CDK1. Daidzein did not affect the expression of any of these proteins. In kinase and pull-down assays, 6,7,4'-THIF, but not daidzein, inhibited CDK1 and CDK2 activities in HCT-116 cells by directly interacting with CDK1 and CDK2. In a xenograft mouse model, 6,7,4'-THIF significantly decreased tumor growth, volume and weight of HCT-116 xenografts. 6,7,4'-THIF bound directly to CDK1 and CDK2 in vivo, resulting in the suppression of CDK1 and CDK2 activity in tumors corresponding with our in vitro results. Collectively, these results suggest that CDK1 and CDK2 are potential molecular targets of 6,7,4'-THIF to suppress HCT-116 cell proliferation in vitro and in vivo. These findings provide insight into the biological actions of 6,7,4'-THIF and might establish a molecular basis for the development of new cancer therapeutic agents. PMID:21258042

  4. Novel approach to the zaragozic acids. Enantioselective total synthesis of 6,7-dideoxysqualestatin H5.

    PubMed

    Naito, Satoru; Escobar, Maya; Kym, Philip R; Liras, Spiros; Martin, Stephen F

    2002-06-14

    The total synthesis of 6,7-dideoxysqualestatin H5 (3) has been completed by a concise approach that features the stereoselective intramolecular vinylogous aldol reaction of the furoic ester 25a to give 30 or its trimethylsilyl ether derivative 34, which possess the requisite absolute stereochemistry at C(3)-C(5) of 3. Compound 34 was reduced to the saturated bislactone 39, and the C(1) side chain subunit 47 was introduced leading to a mixture of the hemiacetals 48 and the corresponding ketone 49. When this mixture was stirred with methanolic acid, transketalization occurred to give a mixture of 50 and the spirocyclic methyl acetals 51a,b. Oxidation of the primary alcohol group in 50 followed by saponification of the two remaining ester groups gave 3. The longest linear sequence in the synthesis commences with commercially available erythronolactone (26) and requires 17 chemical steps with only 10 isolated intermediates. PMID:12054955

  5. MAJOR STRUCTURES OF THE INNER GALAXY DELINEATED BY 6.7 GHz METHANOL MASERS

    SciTech Connect

    Green, J. A.; Caswell, J. L.; McClure-Griffiths, N. M.; Breen, S. L.; Voronkov, M. A.; Avison, A.; Fuller, G. A.; Gray, M. D.; Burton, M. G.; Ellingsen, S. P.; Pestalozzi, M.

    2011-05-20

    We explore the longitude-velocity distribution of 6.7 GHz methanol masers in the context of the inner structure of our Galaxy. We analyze the correlation in velocities within this distribution and identify density enhancements indicating large-scale regions of enhanced star formation. These are interpreted as the starting points of the spiral arms and the interaction of the Galactic bar with the 3 kpc arms. The methanol masers support the presence of a long thin bar with a 45{sup 0} orientation. Signatures of the full 3 kpc arm structure are seen, including a prominent tangent at approximately -22{sup 0} Galactic longitude. We compare this distribution with existing models of the gas dynamics of our Galaxy. The 3 kpc arm structure appears likely to correspond to the radius of corotation resonance of the bar, with the bar on its inner surface and the starting points of the spiral arms on its outer surface.

  6. Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.

    PubMed

    Jiang, Hua-Yi; Wang, Wei-Guang; Zhou, Min; Wu, Hai-Yan; Zhan, Rui; Li, Xiao-Nian; Du, Xue; Li, Yan; Pu, Jian-Xin; Sun, Han-Dong

    2013-11-22

    Fourteen enmein-type 6,7-seco-ent-kaurane diterpenoids, seven new ones (sculponins M-S, 1-7) and seven known compounds (8-14), were isolated from the aerial parts of Isodon sculponeatus . Compound 1 is the first example of an ent-kauranoid, possessing a 11,12-epoxy group, and compounds 6 and 7 have a rare 3,6-epoxy group. The structures were established primarily by NMR and MS methods, and the absolute configurations of 1, 3, and 6 were determined by single-crystal X-ray diffraction. Compound 14 showed significant cytotoxic activity against five human tumor lines, with IC50 values ranging from 1.0 to 3.5 μM, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 2.2 μM. PMID:24219809

  7. Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7.

    PubMed

    Wu, Yisheng; Hillwig, Matthew L; Wang, Qiang; Peters, Reuben J

    2011-11-01

    Rice (Oryza sativa) contains a biosynthetic gene cluster associated with production of at least two groups of diterpenoid phytoalexins, the antifungal phytocassanes and antibacterial oryzalides. While cytochromes P450 (CYP) from this cluster are known to be involved in phytocassane production, such mono-oxygenase activity relevant to oryzalide biosynthesis was unknown. Here we report biochemical characterization demonstrating that CYP71Z6 from this cluster acts as an ent-isokaurene C2-hydroxylase that is presumably involved in the biosynthesis of oryzalides. Our results further suggest that the closely related and co-clustered CYP71Z7 likely acts as a C2-hydroxylase involved in a latter step of phytocassane biosynthesis. Thus, CYP71Z6 & 7 appear to have evolved distinct roles in rice diterpenoid metabolism, offering insight into plant biosynthetic gene cluster evolution. PMID:21985968

  8. Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7

    PubMed Central

    Wu, Yisheng; Hillwig, Matthew L.; Wang, Qiang; Peters, Reuben J.

    2011-01-01

    Rice (Oryza sativa) contains a biosynthetic gene cluster associated with production of at least two groups of diterpenoid phytoalexins, the antifungal phytocassanes and antibacterial oryzalides. While cytochromes P450 (CYP) from this cluster are known to be involved in phytocassane production, such mono-oxygenase activity relevant to oryzalide biosynthesis was unknown. Here we report biochemical characterization demonstrating that CYP71Z6 from this cluster acts as an ent-isokaurene C2-hydroxylase that is presumably involved in the biosynthesis of oryzalides. Our results further suggest that the closely related and co-clustered CYP71Z7 likely acts as a C2-hydroxylase involved in a latter step of phytocassane biosynthesis. Thus, CYP71Z6 & 7 appear to have evolved distinct roles in rice diterpenoid metabolism, offering insight into plant biosynthetic gene cluster evolution. PMID:21985968

  9. The VLBI Monitoring Project for 6.7 GHz Methanol Masers Using the Jvn/eavn

    NASA Astrophysics Data System (ADS)

    Sugiyama, Koichiro; Fujisawa, Kenta; Hachisuka, Kazuya; Yonekura, Yoshinori; Motogi, Kazuhito; Sawada-Satoh, Satoko; Matsumoto, Naoko; Saito, Yu; Hirano, Daiki; Hayashi, Kyonosuke; Shen, Zhiqiang; Honma, Mareki; Hirota, Tomoya; Murata, Yasuhiro; Doi, Akihiro; Niinuma, Kotaro; Dodson, Richard; Rioja, Maria; Ellingsen, Simon; Chen, Xi; Kim, Kee-Tae; Ogawa, Hideo

    2015-09-01

    We have initiated a Very Long Baseline Interferometer (VLBI) monitoring project of 36 methanol maser sources at 6.7 GHz using the Japanese VLBI Network (JVN) and East-Asian VLBI Network (EAVN), starting in August 2010. The purpose of this project is to systematically reveal 3-dimensional (3-D) kinematics of rotating disks around forming high-mass protostars. As an initial result, we present proper motion detections for two methanol maser sources showing an elliptical spatial morphology, G 002.53+00.19 and G 006.79-00.25, which could be the best candidates associated with the disk. The detected proper motions indicate a simple rotation in G 002.53+00.19 and rotation with expansion in G 006.79-00.25, respectively, on the basis of disk model fits with rotating and expanding components. The expanding motions might be caused by the magnetic-centrifugal wind on the disk.

  10. Deformation following the 1994 Northridge earthquake (M=6.7), southern California

    USGS Publications Warehouse

    Savage, J.C.; Svarc, J.L.; Prescott, W.H.; Hudnut, K.W.

    1998-01-01

    Following the 1994 MW=6.7 Northridge earthquake, a 65-km-long, north-south array of 11 geodetic monuments was established across the rupture. The array was surveyed with GPS ten times in the 4.25 yr after the earthquake. Although there is evidence for modest nonlinear postseismic relaxation in the first few weeks after the Northridge earthquake, the deformation in the subsequent four years can be adequately described by constant station velocities. The observed S70??E velocity components are consistent with the deformation expected from steady strain accumulation on the San Andreas fault. The N20??E velocity components indicate that the southern Northridge fault block is moving almost as a unit N20??E with repect to the northern fault block, the motion being accommodated by a zone of convergence (width 20 km) at the north end of the Northridge rupture.Following the 1994 Mw=6.7 Northridge earthquake, a 65-km-long, north-south array of 11 geodetic monuments was established across the rupture. The array was surveyed with GPS ten times in the 4.25 yr after the earthquake. Although there is evidence for modest nonlinear postseismic relaxation in the first few weeks after the Northridge earthquake, the deformation in the subsequent four years can be adequately described by constant station velocities. The observed S70??E velocity components are consistent with the deformation expected from steady strain accumulation on the San Andreas fault. The N20??E velocity components indicate that the southern Northridge fault block is moving almost as a unit N20??E with respect to the northern fault block, the motion being accommodated by a zone of convergence (width 20 km) at the north end of the Northridge rupture.

  11. The magnitude 6.7 Northridge, California, earthquake of 17 January 1994

    USGS Publications Warehouse

    Jones, L.; Aki, K.; Boore, D.; Celebi, M.; Donnellan, A.; Hall, J.; Harris, R.; Hauksson, E.; Heaton, T.; Hough, S.; Hudnut, K.; Hutton, K.; Johnston, M.; Joyner, W.; Kanamori, H.; Marshall, G.; Michael, A.; Mori, J.; Murray, M.; Ponti, D.; Reasenberg, P.; Schwartz, D.; Seeber, L.; Shakal, A.; Simpson, R.; Thio, H.; Tinsley, J.; Todorovska, M.; Trifunac, M.; Wald, D.; Zoback, M.L.

    1994-01-01

    The most costly American earthquake since 1906 struck Los Angeles on 17 January 1994. The magnitude 6.7 Northridge earthquake resulted from more than 3 meters of reverse slip on a 15-kilometer-long south-dipping thrust fault that raised the Santa Susana mountains by as much as 70 centimeters. The fault appears to be truncated by the fault that broke in the 1971 San Fernando earthquake at a depth of 8 kilometers. Of these two events, the Northridge earthquake caused many times more damage, primarily because its causative fault is directly under the city. Many types of structures were damaged, but the fracture of welds in steel-frame buildings was the greatest surprise. The Northridge earthquake emphasizes the hazard posed to Los Angeles by concealed thrust faults and the potential for strong ground shaking in moderate earthquakes.The most costly American earthquake since 1906 struck Los Angeles on 17 January 1994. The magnitude 6.7 Northridge earthquake resulted from more than 3 meters of reverse slip on a 15-kilometer-long south-dipping thrust fault that raised the Santa Susana mountains by as much as 70 centimeters. The fault appears to be truncated by the fault that broke in the 1971 San Fernando earthquake at a depth of 8 kilometers. Of these two events, the Northridge earthquake caused many times more damage, primarily because its causative fault is directly under the city. Many types of structures were damaged, but the fracture of welds in steel-frame buildings was the greatest surprise. The Northridge earthquake emphasizes the hazard posed to Los Angeles by concealed thrust faults and the potential for strong ground shaking in moderate earthquakes.

  12. The Retention of Science Concepts After a Period of Six Months by Students in High School Biology, Chemistry, and Physics, as a Function of Selected Student and Teacher Variables.

    ERIC Educational Resources Information Center

    Haindl, Martin Wilhelm

    Investigated was the relationship between Science Concept Retention by high school science students six months after completion of a course in BSCS biology, CHEMS chemistry, and PSSC physics with each of the following variables: I.Q., Sex, Science Achievement, Natural Science Development, Reading Comprehension, Quantitative Thinking, Delay…

  13. European VLBI Network imaging of 6.7 GHz methanol masers

    NASA Astrophysics Data System (ADS)

    Bartkiewicz, A.; Szymczak, M.; van Langevelde, H. J.

    2016-03-01

    Context. Methanol masers at 6.7 GHz are well known tracers of high-mass star-forming regions. However, their origin is still not clearly understood. Aims: We aimed to determine the morphology and velocity structure for a large sample of the maser emission with generally lower peak flux densities than those in previous surveys. Methods: Using the European VLBI Network (EVN) we imaged the remaining sources from a sample of sources that were selected from the unbiased survey using the Torun 32 m dish. In this paper we report the results for 17 targets. Together they form a database of a total of 63 source images with high sensitivity (3σrms = 15-30 mJy beam-1), milliarcsecond angular resolution (6-10 mas) and very good spectral resolution (0.09 km s-1 or 0.18 km s-1) for detailed studies. Results: We studied in detail the properties of the maser clouds and calculated the mean and median values of the projected size (17.4 ± 1.2 au and 5.5 au, respectively) as well as the FWHM of the line (0.373 ± 0.011 km s-1 and 0.315 km s-1 for the mean and median values, respectively), testing whether it was consistent with Gaussian profile. We also found maser clouds with velocity gradients (71%) that ranged from 0.005 km s-1 au-1 to 0.210 km s-1 au-1. We tested the kinematic models to explain the observed structures of the 6.7 GHz emission. There were targets where the morphology supported the scenario of a rotating and expanding disk or a bipolar outflow. Comparing the interferometric and single-dish spectra we found that, typically, 50-70% of the flux was missing. This phenomena is not strongly related to the distance of the source. Conclusions: The EVN imaging reveals that in the complete sample of 63 sources the ring-like morphology appeared in 17% of sources, arcs were seen in a further 8%, and the structures were complex in 46% cases. The ultra-compact (UC) H II regions coincide in position in the sky for 13% of the sources. They are related both to extremely high and low

  14. Wave number spectra from temperature-humidity infrared radiometer 6.7-micron water vapor data

    NASA Technical Reports Server (NTRS)

    Manney, Gloria L.; Stanford, John L.

    1990-01-01

    Wave number spectra from Nimbus 7 temperature-humidity infrared radiometer 6.7-micron water vapor data are analyzed using series 4800 km long, in regions free of high clouds and frontal zones. In these regions, the brightness temperatures approximate temperatures on a water vapor isosteric (constant density) surface, rather than averages over a broad vertical layer. Power above the noise can be extracted down to wavelengths of about 60 km. Fitting the power spectrum versus horizontal wave number k to a k to the -nth power law for wavelengths from 60 to a few hundred kilometers gives slopes of n = 2.7 to 3.0, depending on the exact wave numbers that are fitted. Thunderstorms and convective cloud systems may constitute an energy source for the reverse energy cascade which produces a -5/3 spectral slope. The results suggest that when these features are not present, the enstrophy-cascading process that gives a -3 slope may govern the motion at scales smaller than it has heretofore been observed.

  15. The Influence of Radiation in Altering the Incidence of Mutations in Drosophila. Progress Report on the Past Twelve Months and Renewal Proposal for the Period September 15, 1960 to September 14, 1961

    DOE R&D Accomplishments Database

    Muller, H. J.

    1960-05-31

    Progress is reported in studies on the effects of radiation on the incidence of mutations in Drosophila. Results are summarized and the findings are interpreted. A list is included of papers published during the period. (C.H.)

  16. Iodine status and thyroid function among Spanish schoolchildren aged 6-7 years: the Tirokid study.

    PubMed

    Vila, L; Donnay, S; Arena, J; Arrizabalaga, J J; Pineda, J; Garcia-Fuentes, E; García-Rey, C; Marín, J L; Serra-Prat, M; Velasco, I; López-Guzmán, A; Luengo, L M; Villar, A; Muñoz, Z; Bandrés, O; Guerrero, E; Muñoz, J A; Moll, G; Vich, F; Menéndez, E; Riestra, M; Torres, Y; Beato-Víbora, P; Aguirre, M; Santiago, P; Aranda, J; Gutiérrez-Repiso, C

    2016-05-01

    I deficiency is still a worldwide public health problem, with children being especially vulnerable. No nationwide study had been conducted to assess the I status of Spanish children, and thus an observational, multicentre and cross-sectional study was conducted in Spain to assess the I status and thyroid function in schoolchildren aged 6-7 years. The median urinary I (UI) and thyroid-stimulating hormone (TSH) levels in whole blood were used to assess the I status and thyroid function, respectively. A FFQ was used to determine the consumption of I-rich foods. A total of 1981 schoolchildren (52 % male) were included. The median UI was 173 μg/l, and 17·9 % of children showed UI<100 μg/l. The median UI was higher in males (180·8 v. 153·6 μg/l; P<0·001). Iodised salt (IS) intake at home was 69·8 %. IS consumption and intakes of ≥2 glasses of milk or 1 cup of yogurt/d were associated with significantly higher median UI. Median TSH was 0·90 mU/l and was higher in females (0·98 v. 0·83; P<0·001). In total, 0·5 % of children had known hypothyroidism (derived from the questionnaire) and 7·6 % had TSH levels above reference values. Median TSH was higher in schoolchildren with family history of hypothyroidism. I intake was adequate in Spanish schoolchildren. However, no correlation was found between TSH and median UI in any geographical area. The prevalence of TSH above reference values was high and its association with thyroid autoimmunity should be determined. Further assessment of thyroid autoimmunity in Spanish schoolchildren is desirable. PMID:26961225

  17. Postseismic relaxation following the 1994 Mw6.7 Northridge earthquake, southern California

    USGS Publications Warehouse

    Savage, J.C.; Svarc, J.L.

    2010-01-01

    We have reexamined the postearthquake deformation of a 65 km long linear array of 11 geodetic monuments extending north–south across the rupture (reverse slip on a blind thrust dipping 40°S–20°W) associated with the 1994 Mw6.7 Northridge earthquake. That array was surveyed frequently in the interval from 4 to 2650 days after the earthquake. The velocity of each of the monuments over the interval 100–2650 days postearthquake appears to be constant. Moreover, the profile of those velocities along the length of the array is very similar to a preearthquake velocity profile for a nearby, similarly oriented array. We take this to indicate that significant postseismic relaxation is evident only in the first 100 days postseismic and that the subsequent linear trend is typical of the interseismic interval. The postseismic relaxation (postseismic displacement less displacement that would have occurred at the preseismic velocity) is found to be almost wholly parallel (N70°W) to the nearby (40 km) San Andreas Fault with only negligible relaxation in the direction of coseismic slip (N20°E) on the Northridge rupture. We suggest that the N70°W relaxation is caused by aseismic, right-lateral slip at depth on the San Andreas Fault, excess slip presumably triggered by the Northridge rupture. Finally, using the Dieterich (1994) stress-seismicity relation, we show that return to the preseismic deformation rate within 100 days following the earthquake could be consistent with the cumulative number of M > 2.5 earthquakes observed following the main shock.

  18. The almost ubiquitous association of 6.7-GHz methanol masers with dust

    NASA Astrophysics Data System (ADS)

    Urquhart, J. S.; Moore, T. J. T.; Menten, K. M.; König, C.; Wyrowski, F.; Thompson, M. A.; Csengeri, T.; Leurini, S.; Eden, D. J.

    2015-02-01

    We report the results of 870-μm continuum observations, using the Large APEX Bolometer Camera, towards 77 class-II, 6.7-GHz methanol masers identified by the Methanol MultiBeam (MMB) survey to map the thermal emission from cool dust towards these objects. These data complement a study of 630 methanol masers associated with compact dense clumps identified from the APEX Telescope Large Area Survey of the Galaxy (ATLASGAL) survey. Compact dust emission is detected towards 70 sources, which implies a dust-association rate of 99 per cent for the full MMB catalogue. Evaluation of the derived dust and maser properties leads us to conclude that the combined sample represents a single population tracing the same phenomenon. We find median clump masses of a few 103 M⊙ and that all but a handful of sources satisfy the mass-size criterion required for massive star formation. This study provides the strongest evidence of the almost ubiquitous association of methanol masers with massive, star-forming clumps. The fraction of methanol-maser associated clumps is a factor of ˜2 lower in the outer Galaxy than the inner Galaxy, possibly a result of the lower metallicity environment of the former. We find no difference in the clump-mass and maser-luminosity distributions of the inner and outer Galaxy. The maser-pumping and clump formation mechanisms are therefore likely to be relatively invariant to Galactic location. Finally, we use the ratio of maser luminosity and clump mass to investigate the hypothesis that the maser luminosity is a good indicator of the evolutionary stage of the embedded source, however, we find no evidence to support this.

  19. Advanced Gas Reactor (AGR)-5/6/7 Fuel Irradiation Experiments in the Advanced Test Reactor

    SciTech Connect

    A. Joseph Palmer; David A. Petti; S. Blaine Grover

    2014-04-01

    The United States Department of Energy’s Very High Temperature Reactor (VHTR) Advanced Gas Reactor (AGR) Fuel Development and Qualification Program will be irradiating up to seven separate low enriched uranium (LEU) tri-isotopic (TRISO) particle fuel (in compact form) experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). These irradiations and fuel development are being accomplished to support development of the next generation reactors in the United States. The goals of the irradiation experiments are to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel performance and fission product transport models and codes, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. The experiments, which each consist of at least five separate capsules, are being irradiated in an inert sweep gas atmosphere with individual on-line temperature monitoring and control of each capsule. The sweep gases also have on-line fission product monitoring the effluent from each capsule to track performance of the fuel during irradiation. The first two experiments (designated AGR-1 and AGR-2), have been completed. The third and fourth experiments have been combined into a single experiment designated AGR-3/4, which started its irradiation in December 2011 and is currently scheduled to be completed in April 2014. The design of the fuel qualification experiment, designated AGR-5/6/7, is well underway and incorporates lessons learned from the three previous experiments. Various design issues will be discussed with particular details related to selection of thermometry.

  20. Vaginal bleeding between periods

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/003156.htm Vaginal bleeding between periods To use the sharing features ... this page, please enable JavaScript. This article discusses vaginal bleeding that occurs between a woman's monthly menstrual ...

  1. Antitumor Effects of Synthetic 6,7-Annulated-4-substituted Indole Compounds in L1210 Leukemic Cells In Vitro

    PubMed Central

    PERCHELLET, JEAN-PIERRE H.; WATERS, ANDREW M.; PERCHELLET, ELISABETH M.; THORNTON, PAUL D.; BROWN, NEIL; HILL, DAVID; NEUENSWANDER, BEN; LUSHINGTON, GERALD H.; SANTINI, CONRAD; CHANDRASOMA, NALIN; BUSZEK, KEITH R.

    2014-01-01

    Background Because annulated indoles have almost no representation in the PubChem or MLSMR databases, an unprecedented class of an indole-based library was constructed, using the indole aryne methodology, and screened for antitumor activity. Sixty-six novel 6,7-annulated-4-substituted indole compounds were synthesized, using a strategic combination of 6,7-indolyne cycloaddition and cross-coupling reactions under both Suzuki-Miyaura and Buchwald-Hartwig conditions, and tested for their effectiveness against murine L1210 tumor cell proliferation in vitro. Materials and Methods Various markers of tumor cell metabolism, DNA degradation, mitotic disruption, cytokinesis and apoptosis were assayed in vitro to evaluate drug cytotoxicity. Results Most compounds inhibited the metabolic activity of leukemic cells in a time- and concentration-dependent manner but only 9 of them were sufficiently potent to inhibit L1210 tumor cell proliferation by 50% in the low-μM range after 2 (IC50: 4.5–20.4 μM) and 4 days (0.5–4.0 μM) in culture. However, the antiproliferative compounds that were the most effective at day 4 were not necessarily the most potent at day 2, suggesting different speeds of action. A 3-h treatment with antiproliferative annulated indole was sufficient to inhibit, in a concentration-dependent manner, the rate of DNA synthesis measured in L1210 cells over a 0.5-h period of pulse-labeling with 3H-thymidine. Four of the antiproliferative compounds had weak DNA-binding activities but one compound reduced the fluorescence of the ethidium bromide-DNA complex by up to 53%, suggesting that some annulated indoles might directly interact with double-stranded DNA to disrupt its integrity and prevent the dye from intercalating into DNA base pairs. However, all 9 antiproliferative compounds induced DNA cleavage at 24 h in L1210 cells, containing 3H-thymidine-prelabeled DNA, suggesting that these antitumor annulated indoles might trigger an apoptotic pathway of DNA

  2. Problem Periods

    MedlinePlus

    ... gov/ Home Body Getting your period Problem periods Problem periods It’s common to have cramps or feel ... doctor Some common period problems Signs of period problems top One way to know if you may ...

  3. Biosynthesis of riboflavin. An aliphatic intermediate in the formation of 6,7-dimethyl-8-ribityllumazine from pentose phosphate.

    PubMed

    Neuberger, G; Bacher, A

    1985-02-28

    6,7-Dimethyl-8-ribityllumazine synthase deficient mutants of Candida guilliermondii were divided into two groups on the basis of in vitro complementation. Mutants of complementation group I produce an intermediate X from ribose 5-phosphate in a reaction requiring Mg++ ions. Compound X was partially purified and was shown to be a phosphoric acid ester. 6,7-Dimethyl-8-ribityllumazine can be formed from Compound X by cell extracts from mutants of complementation group II. The reaction requires 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione or its 5'-phosphate as second substrate. No divalent cations are required. PMID:3838473

  4. Process for manufacturing bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene

    SciTech Connect

    Rasmussen, Paul George; Lawton, Richard Graham

    2014-06-03

    A process to manufacture substituted tetracyano-hexaazatricyclics with the substitutions occurring at the 9 and 10 hydrogens. The process begins with 2,3-dichloro-5,6-dicyanopyrazine, which is reacted to form the desired tetracyano-hexaazatricyclic. Different process embodiments enable different reaction paths to the desired tetracyano-hexaazatricyclic. Different tetracyano-hexaazatricyclic embodiments include bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene and bis(2-methoxyethoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracen- e.

  5. Sequencing of 6.7 Mb of the melon genome using a BAC pooling strategy

    PubMed Central

    2010-01-01

    Background Cucumis melo (melon) belongs to the Cucurbitaceae family, whose economic importance among horticulture crops is second only to Solanaceae. Melon has a high intra-specific genetic variation, morphologic diversity and a small genome size (454 Mb), which make it suitable for a great variety of molecular and genetic studies. A number of genetic and genomic resources have already been developed, such as several genetic maps, BAC genomic libraries, a BAC-based physical map and EST collections. Sequence information would be invaluable to complete the picture of the melon genomic landscape, furthering our understanding of this species' evolution from its relatives and providing an important genetic tool. However, to this day there is little sequence data available, only a few melon genes and genomic regions are deposited in public databases. The development of massively parallel sequencing methods allows envisaging new strategies to obtain long fragments of genomic sequence at higher speed and lower cost than previous Sanger-based methods. Results In order to gain insight into the structure of a significant portion of the melon genome we set out to perform massive sequencing of pools of BAC clones. For this, a set of 57 BAC clones from a double haploid line was sequenced in two pools with the 454 system using both shotgun and paired-end approaches. The final assembly consists of an estimated 95% of the actual size of the melon BAC clones, with most likely complete sequences for 50 of the BACs, and a total sequence coverage of 39x. The accuracy of the assembly was assessed by comparing the previously available Sanger sequence of one of the BACs against its 454 sequence, and the polymorphisms found involved only 1.7 differences every 10,000 bp that were localized in 15 homopolymeric regions and two dinucleotide tandem repeats. Overall, the study provides approximately 6.7 Mb or 1.5% of the melon genome. The analysis of this new data has allowed us to gain further

  6. Cloning, secretory expression and characterization of recombinant β-mannanase from Bacillus circulans NT 6.7.

    PubMed

    Piwpankaew, Yotthachai; Sakulsirirat, Supa; Nitisinprasert, Sunee; Nguyen, Thu-Ha; Haltrich, Dietmar; Keawsompong, Suttipun

    2014-01-01

    The mannanase gene of B. circulans NT 6.7 was cloned and expressed in an Escherichia coli expression system. The B. circulans NT 6.7 mannanase gene consists of 1,083 nucleotides encoding a 360-amino acid residue long polypeptide, belonging to glycoside hydrolase family 26. The full-length mannanase gene including its native signal sequence was cloned into the vector pET21d and expressed in E. coli BL21 (DE3). β-Mannanase activities in the culture supernatant and crude cell extract were 37.10 and 515 U per ml, respectively, with most of the activity in the cell extract attributed to the periplasmic fraction. In contrast, expression of mannanase was much lower when using the B. circulans NT 6.7 mannanase gene without its signal sequence. The optimum temperature of recombinant β-mannanase activity was 50°C and the optimum pH was 6.0. The enzyme was very specific for β-mannan substrates with a preference for galactomannan. Hydrolysis products of locust bean gum were various mannooligosaccharides including mannohexaose, mannopentaose, mannotetraose, mannotriose and mannobiose, while mannose could not be detected. In conclusion, this expression system is efficient for the secretory production of recombinant β-mannanase from B. circulans NT 6.7, which shows good characteristics for various applications. PMID:25157333

  7. Construction and detection of the tissue-specific pINV-HPV16 E6/7 vector

    PubMed Central

    GAO, HUI; HUANG, ZHENGFANG; SHI, CHENLONG; LI, HOUDA

    2015-01-01

    A tissue-specific promoter can control downstream gene expression in tissues or organs. The human involucrin (hINV) promoter (pINV) that contains 2474 bp of hINV upstream sequence is able to regulate tissue-specific gene expression. This tissue specificity may be important for the prevention and treatment of human papilloma virus infections. pINV was cloned by polymerase chain reaction and the human papillomavirus (HPV)16 E6/7 gene was obtained from the cancer tissue samples of patients with cervical carcinoma at the Yangzhou Maternal and China Health-Care Center of Jinagsu Province (Yangzhou, China). First, specific primers were designed according to the genomic DNA sequence of the HPV16-type standard strain that has been reported and the E6/7 gene was acquired by PCR. The carcinogenic fraction of the E6/7 gene was removed and the remaining section was cloned into T vectors, sequenced correctly and then cloned into the eukaryotic expression vector pCEP4, which was lacking the CMV promoter. The positive recombinants were identified using blue-white screening and endonuclease digestion, subsequent to sequencing and analysis, and the tissue-specific recombinant pINV-HPV16E6/7 plasmids was detected. PMID:25621060

  8. Natural gas monthly

    SciTech Connect

    Not Available

    1982-11-01

    This report presents data on the supply and disposition of natural gas in the USA during July 1982, as well as data on production, storage, imports, exports, and consumption. Selected data are also presented on the activities of the major interstate pipeline companies. Volumes of natural gas in storage continue to run slightly ahead of year-ago levels, especially for interstate operators. Weighted average prices received for gas sold by major interstate pipeline companies during July of 19982 ranged from a low of $2.61 per thousand cubic feet (Mcf) for Kansas-Nebraska to a high of $7.09 per Mcf for Pacific Gas. These variations are attributable to the sources of supply available to the various pipeline companies and the market structures of each. September 1982 applications for determination of a maximum lawful price under the Natural Gas Policy Act (NGPA) increased slightly for new gas (Section 102) and decreased significantly for high-cost gas (Section 107) when compared to August. Natural gas ceiling prices prescribed by the NGPA continued to move upward through the application of prescribed monthly inflation adjustments. In the 3-year period from November 1979 through November 1982, the price ceiling for new gas, for example, increased from $2.314 to $3.249 per million (MM) Btu's. The highest ceiling price permitted under the NGPA is natural gas produced from tight formations set for November 1982 at $5.396 per MMBtu. Market natural gas production during September of 1982 was 1444 billion cubic feet (Bcf) compared to the September 1981 level of 1578 Bcf. Consumption during the same period also declined from 1266 Bcf to 1176 Bcf.

  9. Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium, vitamin D, and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II.

    PubMed

    Kanellakis, Spyridon; Moschonis, George; Tenta, Roxane; Schaafsma, Anne; van den Heuvel, Ellen G H M; Papaioannou, Nikolaos; Lyritis, George; Manios, Yannis

    2012-04-01

    The objective of the present study was to examine the effect of dairy products enriched with calcium, vitamin D(3), and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K(2)) on parameters of bone metabolism in postmenopausal women following a 12-month intervention. Postmenopausal women were divided into three intervention groups and a control group (CG). All three intervention groups attended biweekly sessions and received fortified dairy products providing daily 800 mg of calcium and 10 μg of vitamin D(3) (CaD). Furthermore, in two of the three intervention groups the dairy products were also enriched with vitamin K, providing daily 100 μg of either phylloquinone (CaDK1) or menaquinone-7 (CaDK2). The increase observed for serum 25(OH)D levels in all intervention groups and the increase observed for serum IGF-I levels in the CaDK2 group differed significantly compared to the changes observed in CG (P = 0.010 and P = 0.028, respectively). Furthermore, both the CaDK1 and CaDK2 groups had a significantly lower mean serum undercarboxylated osteocalcin to osteocalcin ratio and urine deoxypyridinoline levels at follow-up compared to the CaD and CG groups (P = 0.001 and P = 0.047, respectively). Significant increases in total-body BMD were observed in all intervention groups compared to CG (P < 0.05), while significant increases in lumbar spine BMD were observed only for CaDK1 and CaDK2 compared to CG (P < 0.05) after controlling for changes in serum 25(OH)D levels and dietary calcium intake. In conclusion, the present study revealed more favorable changes in bone metabolism and bone mass indices for the two vitamin K-supplemented groups, mainly reflected in the suppression of serum levels of bone remodeling indices and in the more positive changes in lumbar spine BMD for these two study groups. PMID:22392526

  10. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H{sub 2} hydrogenation reaction network.

  11. VizieR Online Data Catalog: 6.7GHz methanol masers survey of low-mass YSO (Minier+, 2003)

    NASA Astrophysics Data System (ADS)

    Minier, V.; Ellingsen, S. P.; Norris, R. P.; Booth, R. S.

    2003-07-01

    We report the results of a search for 6.7-GHz methanol masers toward low-mass young stellar objects (YSOs) and (pre)protostellar condensations with the Australia Telescope Compact Array (ATCA). Our sample consisted of 13 class 0 protostars and 44 class I YSOs as well as 66 (pre)protostellar condensations. A single detection was obtained toward NGC 2024: FIR4 in the Orion B region. This is the first detection of a 6.7-GHz methanol maser in Orion. The nature of FIR4 has been a subject of debate with some evidence suggesting that it is a very cold high-mass (pre)protostellar condensation and others arguing that it is a low-mass YSO. The discovery of a methanol maser associated with this source is inconsistent with both of these hypotheses and we suggest that FIR4 probably harbours an intermediate- or high-mass YSO. (1 data file).

  12. VizieR Online Data Catalog: 6.7GHz methanol maser polarization in SFR (Surcis+, 2015)

    NASA Astrophysics Data System (ADS)

    Surcis, G.; Vlemmings, W. H. T.; van Langevelde, H. J.; Hutawarakorn Kramer, B.; Bartkiewicz, A.; Blasi, M. G.

    2015-09-01

    The first seven massive SFRs were observed at 6.7GHz in full polarization spectral mode with eight of the EVN antennas (Effelsberg, Jodrell, Onsala, Medicina, Noto, Torun, Westerbork, and Yebes-40m) between November 2012 and June 2013, for a total observation time of 49h. The bandwidth was 2MHz, providing a velocity range of ~100km/s. (8 data files).

  13. Euphorikanin A, a Diterpenoid Lactone with a Fused 5/6/7/3 Ring System from Euphorbia kansui.

    PubMed

    Fei, Dong-Qing; Dong, Le-Le; Qi, Feng-Ming; Fan, Gai-Xia; Li, Hui-Hong; Li, Zheng-Yu; Zhang, Zhan-Xin

    2016-06-17

    Euphorikanin A (1), an unprecedented diterpenoid lactone which possesses a novel 5/6/7/3-fused tetracyclic ring skeleton, was isolated from the roots of Euphorbia kansui. The chemical structure and absolute stereochemistry were elucidated on the basis of extensive spectroscopic methods and single-crystal X-ray diffraction analysis. Compound 1 exhibited moderate cytotoxicity against two human tumor cell lines HeLa and NCI-446. A proposed biosynthetic pathway of compound 1 is also described. PMID:27230557

  14. Characterization of mannanase from Bacillus circulans NT 6.7 and its application in mannooligosaccharides preparation as prebiotic.

    PubMed

    Pangsri, Phanwipa; Piwpankaew, Yotthachai; Ingkakul, Arunee; Nitisinprasert, Sunee; Keawsompong, Suttipun

    2015-01-01

    This study focused on the characterization of mannanase from Bacillus circulans NT 6.7 for mannooligosaccharides (MOS) production. The enzyme from B. circulans NT 6.7 was produced using defatted copra meal as a carbon source. The mannanase was purified by ultrafiltration and column chromatography of Q-Sepharose. The purified protein (M1) was a dimeric protein with a 40 kDa subunit. The purified M1 exhibited optimum pH and temperature at pH 6.0 and 60 °C, respectively. It was activated by Mn(2+,) Mg(2+,) and Cu(2+), and as inhibited by EDTA (45-65 %). The purified enzyme exhibited high specificity to beta-mannan: konjac (glucomannan), locust bean gum (galactomannan), ivory nut (mannan), guar gum (galactomannan) and defatted copra meal (galactomannan). The defatted copra meal could be hydrolyzed by purified M1 into mannooligosaccharides which promoted beneficial bacteria, especially Lactobacillus group, and inhibited pathogenic bacteria; Shigella dysenteria DMST 1511, Staphylococcus aureus TISTR 029, and Salmonella enterica serovar Enteritidis DMST 17368. Therefore, the mannanase from B. circulans NT 6.7 would be a novel source of enzymes for the mannooligosaccharides production as prebiotics. PMID:26697281

  15. Hispanic Heritage Month

    NASA Video Gallery

    Hispanic-themed music and Salsa dance performances helped kick off the Johnson Space Center celebration of Hispanic Heritage Month, commemorating the histories, cultures and contributions of Hispan...

  16. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  17. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  18. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  19. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  20. 40 CFR 721.9504 - Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8-tridecafluorooctyl)-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, triethoxy (3,3,4,4,5,5, 6,6,7... Significant New Uses for Specific Chemical Substances § 721.9504 Silane, triethoxy (3,3,4,4,5,5, 6,6,7,7,8,8,8... substance identified as silane, triethoxy (3,3,4,4,5, 5,6,6,7,7,8,8,8-tridecafluorooctyl)- (PMN...

  1. On the Period-Amplitude and Amplitude-Period Relationships

    NASA Technical Reports Server (NTRS)

    Wilson, Robert M.; Hathaway, David H.

    2008-01-01

    Examined are Period-Amplitude and Amplitude-Period relationships based on the cyclic behavior of the 12-month moving averages of monthly mean sunspot numbers for cycles 0.23, both in terms of Fisher's exact tests for 2x2 contingency tables and linear regression analyses. Concerning the Period-Amplitude relationship (same cycle), because cycle 23's maximum amplitude is known to be 120.8, the inferred regressions (90-percent prediction intervals) suggest that its period will be 131 +/- 24 months (using all cycles) or 131 +/- 18 months (ignoring cycles 2 and 4, which have the extremes of period, 108 and 164 months, respectively). Because cycle 23 has already persisted for 142 months (May 1996 through February 2008), based on the latter prediction, it should end before September 2008. Concerning the Amplitude-Period relationship (following cycle maximum amplitude versus preceding cycle period), because cycle 23's period is known to be at least 142 months, the inferred regressions (90-percent prediction intervals) suggest that cycle 24's maximum amplitude will be about less than or equal to 96.1 +/- 55.0 (using all cycle pairs) or less than or equal to 91.0 +/- 36.7 (ignoring statistical outlier cycle pairs). Hence, cycle 24's maximum amplitude is expected to be less than 151, perhaps even less than 128, unless cycle pair 23/24 proves to be a statistical outlier.

  2. Birth Month Affects Longevity

    ERIC Educational Resources Information Center

    Abel, Ernest L.; Kruger, Michael L.

    2010-01-01

    The authors examined the association between birth month and longevity for major league baseball players. Players born in the month of November had the greatest longevities whereas those born in June had the shortest life spans. These differences remained after controlling for covariates such as birth year, career length, age at debut, height, and…

  3. 20 CFR 220.171 - The reentitlement period.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... reentitlement period begins with the first month following completion of nine months of trial work but cannot... the annuitant completed nine months of trial work in that period in which he or she was disabled....

  4. A 9-month-old with bradycardia and periodic apnea.

    PubMed

    Kraft, M E

    1998-10-01

    The patient was discharged approximately 36 hours after admission to the emergency department. At that time she was awake and alert and responding appropriately to her surroundings. Her vital signs were within normal limits. It took approximately 2 weeks to receive the baby's clonidine level, which was 11.0 ng/mL; the therapeutic level is between 0.5 to 4.5 ng/mL. We came to the conclusion that the babysitter's clonidine patch had accidentally fallen into the playpen, where the baby subsequently sucked on it. To this day, the babysitter denies any involvement. Situations such as this confront emergency nurses every day, and questions arise regarding intent. In this case, the physician interviewed the babysitter and believed that the overdose was unintentional. Once again we are reminded of the fragility of life, the importance of capable, cautious caregivers, and just how easily accidents can happen. What a happy outcome this turned out to be after what appeared to be such a grave medical emergency on presentation! PMID:9814264

  5. 45 CFR 233.32 - Payment and budget months (AFDC).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.32 Payment and budget months (AFDC). A State... 45 Public Welfare 2 2010-10-01 2010-10-01 false Payment and budget months (AFDC). 233.32 Section... period used to determine that payment (budget month) and whether it adopts (a) a one-month or...

  6. 45 CFR 233.32 - Payment and budget months (AFDC).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Payment and budget months (AFDC). 233.32 Section... CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.32 Payment and budget months (AFDC). A State... period used to determine that payment (budget month) and whether it adopts (a) a one-month or...

  7. 45 CFR 233.32 - Payment and budget months (AFDC).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Payment and budget months (AFDC). 233.32 Section... CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.32 Payment and budget months (AFDC). A State... period used to determine that payment (budget month) and whether it adopts (a) a one-month or...

  8. 45 CFR 233.32 - Payment and budget months (AFDC).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Payment and budget months (AFDC). 233.32 Section... CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.32 Payment and budget months (AFDC). A State... period used to determine that payment (budget month) and whether it adopts (a) a one-month or...

  9. 45 CFR 233.32 - Payment and budget months (AFDC).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Payment and budget months (AFDC). 233.32 Section... CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.32 Payment and budget months (AFDC). A State... period used to determine that payment (budget month) and whether it adopts (a) a one-month or...

  10. 26 CFR 31.6011(a)-5 - Monthly returns.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... IRS shall make a return for the calendar month in which the notice is received, for each of the prior calendar months in the return period, and for each calendar month afterwards (whether or not wages are paid in any such month) until the employer has filed a final return or is required to make quarterly...

  11. 26 CFR 31.6011(a)-5 - Monthly returns.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... IRS shall make a return for the calendar month in which the notice is received, for each of the prior calendar months in the return period, and for each calendar month afterwards (whether or not wages are paid in any such month) until the employer has filed a final return or is required to make quarterly...

  12. 26 CFR 31.6011(a)-5 - Monthly returns.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... IRS shall make a return for the calendar month in which the notice is received, for each of the prior calendar months in the return period, and for each calendar month afterwards (whether or not wages are paid in any such month) until the employer has filed a final return or is required to make quarterly...

  13. 26 CFR 31.6011(a)-5 - Monthly returns.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... IRS shall make a return for the calendar month in which the notice is received, for each of the prior calendar months in the return period, and for each calendar month afterwards (whether or not wages are paid in any such month) until the employer has filed a final return or is required to make quarterly...

  14. 26 CFR 31.6011(a)-5 - Monthly returns.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... IRS shall make a return for the calendar month in which the notice is received, for each of the prior calendar months in the return period, and for each calendar month afterwards (whether or not wages are paid in any such month) until the employer has filed a final return or is required to make quarterly...

  15. Medical Care and Your 8- to 12-Month-Old

    MedlinePlus

    ... Pregnancy Medical Care and Your 8- to 12-Month-Old KidsHealth > For Parents > Medical Care and Your 8- to 12-Month-Old Print A A A Text Size What's ... baby visits during this period, once at 9 months and again at 12 months . If you have ...

  16. Natural gas monthly, February 1997

    SciTech Connect

    1997-02-01

    This issue of the Natural Gas Monthly presents estimates of natural gas supply and consumption through February 1997. Estimates of natural gas prices are through November 1996 except electric utility prices that are through October 1996. Cumulatively for January through February 1997, the daily average rates for several data series remain close to those of 1996. (Comparing daily rates accounts for the fact that February 1996 had 29 days.) Daily total consumption for January through February is estimated to be 83 billion cubic feet per day, 1 percent higher than during the same period in 1996. Similarly, the estimate of average daily production of 53 billion cubic feet is 1.5 percent higher than in 1996, while daily net imports during the first 2 months of 1997 are virtually unchanged from 1996.

  17. A Williams syndrome patient with a familial t(6;7) translocation and deletion of the elastin gene

    SciTech Connect

    Pober, B.R.; Gibson, L.H.; Yang-Feng, T.L.

    1994-09-01

    Discovery of a {open_quotes}balanced{close_quotes} reciprocal translocation [46,XX,t(6;7)(q11.2;q11.23)] on routine amniocentesis prompted clinical and cytogenetic study of additional family members. The same t(6;7) translocation was found in the clincally normal father and in a sibling with Williams syndrome (WS). WS had been diagnosed previously according to clinical criteria including distinctive facial features, supravalvar aortic stenosis requiring surgical repair, dental abnormalties and developmental delay. A clinically normal female was delivered and the translocation was confirmed with a cord blood specimen. Hemizygosity for the gene, elastin, (which has been mapped to the chromosome 7 translocation breakpoint, 7q11.23, in this family) appears to be a cause of WS. We therefore investigated whether the t(6;7) in the phenotypically normal father represented more than a simple reciprocal translocation. FISH using a chromosome 7 specific library revealed no differences between the cytogenetically identical, yet phenotypically distinct, father and son. Hybridization with a cosmid MR127D4 containing elastin sequence showed that the WS patient was missing one allele from the derivative chromosome 7 whereas both his mother and father had two copies of the elastin gene. This family indicates that the de novo loss of one copy of the elastin gene produces the recognizable phenotype of Williams syndrome. Molecular characterization (with additional probes) of the extent of this de novo deletion near the translocation breakpoint is in progress. This information will be valuable for defining the WS-critical region and will lead to a better understanding of the molecular basis for WS.

  18. A longitudinal study of grapheme-color synesthesia in childhood: 6/7 years to 10/11 years

    PubMed Central

    Simner, Julia; Bain, Angela E.

    2013-01-01

    Grapheme-color synesthesia is a condition characterized by enduring and consistent associations between letter/digits and colors. This study is the continuation of longitudinal research begun by Simner et al. (2009) which aimed to explore the development of this condition in real time within a childhood population. In that earlier study we randomly sampled over 600 children and tested them aged 6/7 and 7/8 years. We identified the child synesthetes within that cohort and measured their development over 1 year, in comparison to a group of non-synesthetic children with both average and superior memories. We were able to show the beginnings of a developmental progression in which synesthetic associations (e.g., A = red) mature over time from relatively chaotic pairings into a system of fixed consistent associations. In the current study we return to this same population three years later when participants are now 10/11 years. We used the same paired-association memory task to determine the synesthetic status of our participants and to also establish synesthetes' inventories of grapheme-color associations. We compared their inventories to those from age 6/7 and 7/8 years to examine how synesthesia matures over time. Together with earlier findings, our study shows that grapheme-color synesthesia emerges with a protracted trajectory, with 34% of letters/digits fixed at age 6/7 years, 48% fixed at 7/8 years and 71% fixed at 10/11 years. We also show several cases where synesthesia is not developing in the same time-frame as peers, either because it has died out at an older age, or because it was slower to develop than other cases. Our study paints the first picture of the emergence of synesthesia in real-time over four years within a randomly sampled population of child synesthetes. PMID:24312035

  19. Phagraphene: A Low-Energy Graphene Allotrope Composed of 5-6-7 Carbon Rings with Distorted Dirac Cones.

    PubMed

    Wang, Zhenhai; Zhou, Xiang-Feng; Zhang, Xiaoming; Zhu, Qiang; Dong, Huafeng; Zhao, Mingwen; Oganov, Artem R

    2015-09-01

    Using systematic evolutionary structure searching we propose a new carbon allotrope, phagraphene [fæ'græfi:n], standing for penta-hexa-hepta-graphene, because the structure is composed of 5-6-7 carbon rings. This two-dimensional (2D) carbon structure is lower in energy than most of the predicted 2D carbon allotropes due to its sp(2)-binding features and density of atomic packing comparable to graphene. More interestingly, the electronic structure of phagraphene has distorted Dirac cones. The direction-dependent cones are further proved to be robust against external strain with tunable Fermi velocities. PMID:26262429

  20. Hydrous carbonates on Mars?: evidence from Mariner 6/7 infrared spectrometer and ground-based telescopic spectra

    USGS Publications Warehouse

    Calvin, W.M.; King, T.V.V.; Clark, R.N.

    1994-01-01

    Absorption features at 2.28 and 5.4 ??m identified in Mariner 6/7 infrared spectrometer and terrestrial telescopic spectra are consistent with the spectra of hydrous magnesium carbonates such as hydromagnesite and artinite. Spectral characteristics of these hydrous carbonates are different from those of the anhydrous carbonates, as the former do not have the strong spectral features typically associated with anhydrous carbonates such as calcite and siderite. Although the spectroscopic evidence for anhydrous carbonates is scant, the possible presence of hydrous carbonates provides an appealing mechanism for the existence of carbonates on Mars. -from Authors

  1. The effect of viewing angle on the spectral behavior of a Gd plasma source near 6.7 nm

    SciTech Connect

    O'Gorman, Colm; Li Bowen; Cummins, Thomas; Dunne, Padraig; Sokell, Emma; O'Sullivan, Gerry; Otsuka, Takamitsu; Yugami, Noboru; Higashiguchi, Takeshi; Jiang Weihua; Endo, Akira

    2012-04-02

    We have demonstrated the effect of viewing angle on the extreme ultraviolet (EUV) emission spectra of gadolinium (Gd) near 6.7 nm. The spectra are shown to have a strong dependence on viewing angle when produced with a laser pulse duration of 10 ns, which may be attributed to absorption by low ion stages of Gd and an angular variation in the ion distribution. Absorption effects are less pronounced at a 150-ps pulse duration due to reduced opacity resulting from plasma expansion. Thus for evaluating source intensity, it is necessary to allow for variation with both viewing angle and target orientation.

  2. Comparison of energy calibration of Prognoz 5, 6, 7, and 8 and other hard-X-ray solar photometers

    NASA Astrophysics Data System (ADS)

    Farnik, F.; Valnicek, B.; Sylwester, B.; Sylwester, J.; Jakimiec, J.

    1984-08-01

    The data obtained by the Prognoz 5, 6, 7, and 8 hard-X-ray photometers are compared with the measurements carried out by similar instruments aboard Solrad 11, ISEE 3, SMM, and Hinotori satellites. Using the method of relative-amplitude analysis, the apparent disagreement in the energy-discrimination-level calibration between the instruments is pointed out. The results of the comparison and possible sources of disagreement are given. An international effort to develop a system of uniform prelaunch calibration of photometers based on a reference calibration source is suggested.

  3. Elastic Scattering Of {sup 6,7}Li+{sup 80}Se At Near And Above Barrier Energies

    SciTech Connect

    Fimiani, L.; Marti, G. V.; Capurro, O. A.; Barbara, E. de; Testoni, J. E.; Zalazar, L.; Arazi, A.; Cardona, M. A.; Carnelli, P.; Figueira, J. M.; Hojman, D.; Martinez Heimann, D.; Negri, A. E.; Pacheco, A. J.; Fernandez Niello, J. O.

    2010-08-04

    In this work we propose to study the elastic scattering of the weakly bound projectiles {sup 6,7}Li on an intermediate mass target {sup 80}Se. From the experimental results presented here, precise angular distributions at energies below, around and above the nominal Coulomb barriers of the systems were obtained. The final goal of our work is to determine the characteristic parameters of the optical potential and use them to address the question of whether the usual threshold anomaly or the breakup threshold anomaly are present or not in these systems.

  4. Quasi-elastic Scattering Measurements in the {sup 6,7}Li+{sup 144}Sm Systems

    SciTech Connect

    Capurro, O. A.; Arazi, A.; Fernandez Niello, J. O.; Figueira, J. M.; Marti, G. V.; Martinez Heimann, D.; Negri, A. E.; Pacheco, A. J.; Monteiro, D. S.; Otomar, D. R.; Gomes, P. R. S.

    2009-06-03

    In the present work, results of measurements of quasi-elastic scattering cross sections using a silicon-telescope detector at backward angles are reported. They allowed us to deduce fusion barrier distributions from the first derivative of the corresponding excitation function (-d(d{sigma}{sub qes}/d{sigma}{sub Rut})/dE). We report data for the systems {sup 6,7}Li on {sup 144}Sm which are characterized by loosely bound projectiles onto a closed neutron shell target. The experimental excitation functions and the associated barrier distributions are compared for both systems.

  5. Natural Gas Monthly

    EIA Publications

    2016-01-01

    Highlights activities, events, and analyses associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer related activities and underground storage data are also reported.

  6. Irregular Periods

    MedlinePlus

    ... number of days after the last one. The Menstrual Cycle Most girls get their first period between the ... to skip periods or to have an irregular menstrual cycle. Illness, rapid weight change, or stress can also ...

  7. Estimation of doses to Taikonauts in SZ-5/6/7 missions using a male voxel model

    NASA Astrophysics Data System (ADS)

    Xu, Feng; Zeng, Zhi; Jia, Xianghong

    2011-11-01

    Objective To assess the Taikonaut's space radiation risk organ, doses have been calculated using a male voxel model. Methods A male voxel model based on MRI was built. The proton spectra were calculated by AP-8 with SPENVIS and Badhwar's GCR model. The general 3 D Monte Carlo particle and heavy ion transport code GEANT4 was used to calculate the average doses for some organs and tissues. Results After 1 g/cm2 shielding shell, the absorbed dose rate of skin is 0.6 mGy/d and effective dose rate is estimated to be 2.3 mSv/d during the SZ-5/6/7 mission. The total effective dosesof the taikonauts are estimated to be around 2.0 mSv during the SZ-5 mission, 10.9mSv during the SZ-6 mission and 6.5 mSv during the SZ-7 mission separately. Conclusion The calculated skin doses are closed to the values measured by TLDs in SZ-5/6/7, and within the range of 0.2~0.6mSv published by USA and Russia.

  8. Estimation of doses to Taikonauts in SZ-5/6/7 missions using a male voxel model

    NASA Astrophysics Data System (ADS)

    Xu, Feng; Zeng, Zhi; Jia, Xianghong

    2012-03-01

    Objective To assess the Taikonaut's space radiation risk organ, doses have been calculated using a male voxel model. Methods A male voxel model based on MRI was built. The proton spectra were calculated by AP-8 with SPENVIS and Badhwar's GCR model. The general 3 D Monte Carlo particle and heavy ion transport code GEANT4 was used to calculate the average doses for some organs and tissues. Results After 1 g/cm2 shielding shell, the absorbed dose rate of skin is 0.6 mGy/d and effective dose rate is estimated to be 2.3 mSv/d during the SZ-5/6/7 mission. The total effective dosesof the taikonauts are estimated to be around 2.0 mSv during the SZ-5 mission, 10.9mSv during the SZ-6 mission and 6.5 mSv during the SZ-7 mission separately. Conclusion The calculated skin doses are closed to the values measured by TLDs in SZ-5/6/7, and within the range of 0.2~0.6mSv published by USA and Russia.

  9. Centromere-linked microsatellite markers for linkage groups 3, 4, 6, 7, 13, and 20 of zebrafish (Danio rerio).

    PubMed

    Mohideen, M A; Moore, J L; Cheng, K C

    2000-07-01

    A large number of interesting mutations affecting development and organogenesis have been identified through genetic screens in zebrafish. Mapping of these mutations to a chromosomal region can be rapidly accomplished using half-tetrad analysis. However, knowledge of centromere-linked markers on every chromosome is essential to this mapping method. Centromeres on all 25 linkage groups have been mapped on the RAPD zebrafish genetic map. However, species specificity and the lack of codominance make RAPD markers less practical for mapping than microsatellite-based markers. On the microsatellite-based genetic map, centromere-linked markers have been identified for 19 linkage groups. No direct evidence has been published linking microsatellite markers to the centromeres of linkage groups 3, 4, 6, 7, 13, and 20. Therefore, we compared the microsatellite-based genetic map with the RAPD map to identify markers most likely linked to the centromeres of these 6 linkage groups. These candidate markers were tested for potential centromere linkage using four panels of half-tetrad embryos derived by early-pressure treatment of eggs from four different female zebrafish. We have identified microsatellite markers for linkage groups 3, 4, 6, 7, 13, and 20 to within 1.7 cM of their centromeres. These markers will greatly facilitate the rapid mapping of mutations in zebrafish by half-tetrad analysis. PMID:10945477

  10. Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase

    PubMed Central

    Lanyon-Hogg, Thomas; Masumoto, Naoko; Bodakh, George; Konitsiotis, Antonio D.; Thinon, Emmanuelle; Rodgers, Ursula R.; Owens, Raymond J.; Magee, Anthony I.; Tate, Edward W.

    2016-01-01

    In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article “Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase” (Lanyon-Hogg et al., 2015) [1]. 1H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors. PMID:27077078

  11. 2-(Alkylamino)-3-aryl-6,7-dihydrobenzofuran-4(5H)-ones: Improved Synthesis and their Photophysical Properties

    PubMed Central

    Kumar, Manoj; Kumawat, Lokesh Kumar; Gupta, Vinod Kumar; Sharma, Anuj

    2015-01-01

    Furans are an important class of compounds and exhibit a diverse range of activities and properties. As such, improved synthetic access to furans is an important research goal. In the present report, a solvent- and catalyst-free reaction between 5,5-dimethyl-1,3-cyclohexanedione (dimedone), an aryl aldehyde and an isocyanide under microwave irradiation is presented. This method is significantly improved from previously described protocols in terms of applicability of wide ranging aryl aldehydes, better yields, shorter reaction times, facile work up and essentially no need of column chromatography. The photophysical properties of this series of compounds were studied for their possible applicability in the field of metal ion sensors. In solution, two compounds, 2-(cyclohexylamino)-3-(1H-indol-3-yl)-6,6-dimethyl-6,7-dihydrobenzofuran-4(5H)-one (1 i) and 2-(tert-butylamino)-3-(1H-indol-3-yl)-6,6-dimethyl-6,7-dihydrobenzofuran-4(5H)-one (1 j), underwent an observable color change from yellow to colorless in the presence of aluminum(III) ions. Further studies to investigate the UV absorption and luminescence behavior of these compounds revealed their utility as “naked-eye sensors” for aluminum detection. PMID:26491643

  12. Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase.

    PubMed

    Lanyon-Hogg, Thomas; Masumoto, Naoko; Bodakh, George; Konitsiotis, Antonio D; Thinon, Emmanuelle; Rodgers, Ursula R; Owens, Raymond J; Magee, Anthony I; Tate, Edward W

    2016-06-01

    In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed "RU-SKI") class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article "Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase" (Lanyon-Hogg et al., 2015) [1]. (1)H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors. PMID:27077078

  13. Getting Your Period

    MedlinePlus

    ... for a woman to have a baby. During sexual intercourse, the egg can get fertilized by a male’s sperm and then attach to the lining of the uterus ( endometrium ) and grow into a baby. ( Read more about reproduction. ) Does your period come each month? top Menstrual ...

  14. 12 CFR 561.6 - Audit period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Audit period. 561.6 Section 561.6 Banks and... SAVINGS ASSOCIATIONS § 561.6 Audit period. The audit period of a savings association means the twelve month period (or other period in the case of a change in audit period) covered by the annual...

  15. Developmental milestones record - 9 months

    MedlinePlus

    Growth milestones for children - 9 months; Childhood growth milestones - 9 months; Normal childhood growth milestones - 9 months ... provider. PHYSICAL CHARACTERISTICS AND MOTOR SKILLS A 9-month-old has usually reached the following milestones: Gains ...

  16. Developmental milestones record - 12 months

    MedlinePlus

    Normal childhood growth milestones - 12 months; Growth milestones for children - 12 months; Childhood growth milestones - 12 months ... care provider. PHYSICAL AND MOTOR SKILLS A 12-month-old child is expected to: Be 3 times ...

  17. Developmental milestones record - 18 months

    MedlinePlus

    Growth milestones for children - 18 months; Normal childhood growth milestones - 18 months; Childhood growth milestones - 18 months ... PHYSICAL AND MOTOR SKILL MARKERS The typical 18-month-old: Has a closed soft spot on the ...

  18. Developmental milestones record - 4 months

    MedlinePlus

    Normal childhood growth milestones - 4 months; Childhood growth milestones - 4 months; Growth milestones for children - 4 months ... provider. PHYSICAL AND MOTOR SKILLS The typical 4-month-old baby should: Slow in weight gain to ...

  19. Developmental milestones record - 6 months

    MedlinePlus

    Normal childhood growth milestones - 6 months; Childhood growth milestones - 6 months; Growth milestones for children - 6 months ... the weight on hands (often occurs by 4 months) Able to pick up a dropped object Able ...

  20. Natural gas monthly, March 1999

    SciTech Connect

    1999-03-01

    This issue of the Natural Gas Monthly contains estimates for March 1999 for many natural gas data series at the national level. Estimates of national natural gas prices are available through December 1998 for most series. Highlights of the data contained in this issue are listed below. Preliminary data indicate that the national average wellhead price for 1998 declined to 16% from the previous year ($1.96 compared to $2.32 per thousand cubic feet). At the end of March, the end of the 1998--1999 heating season, the level of working gas in underground natural gas storage facilities is estimated to be 1,354 billion cubic feet, 169 billion cubic feet higher than at the end of March 1998. Gas consumption during the first 3 months of 1999 is estimated to have been 179 billion cubic feet higher than in the same period in 1998. Most of this increase (133 billion cubic feet) occurred in the residential sector due to the cooler temperatures in January and February compared to the same months last year. According to the National Weather Service, heating degree days in January 1999 were 15% greater than the previous year while February recorded a 5% increase.

  1. Systematic investigation of self-absorption and conversion efficiency of 6.7 nm extreme ultraviolet sources

    SciTech Connect

    Otsuka, Takamitsu; Higashiguchi, Takeshi; Yugami, Noboru; Yatagai, Toyohiko; Kilbane, Deirdre; Dunne, Padraig; O'Sullivan, Gerry; Jiang, Weihua; Endo, Akira

    2010-12-06

    We have investigated the dependence of the spectral behavior and conversion efficiencies of rare-earth plasma extreme ultraviolet sources with peak emission at 6.7 nm on laser wavelength and the initial target density. The maximum conversion efficiency was 1.3% at a laser intensity of 1.6x10{sup 12} W/cm{sup 2} at an operating wavelength of 1064 nm, when self-absorption was reduced by use of a low initial density target. Moreover, the lower-density results in a narrower spectrum and therefore improved spectral purity. It is shown to be important to use a low initial density target and/or to produce low electron density plasmas for efficient extreme ultraviolet sources when using high-Z targets.

  2. New 2-phenyl-4,5,6,7-tetrahydro-2H-indazole derivatives as paddy field herbicides.

    PubMed

    Hwang, In Taek; Kim, Hyoung Rae; Jeon, Dong Ju; Hong, Kyung Sik; Song, Jong Hwan; Chung, Chang Kook; Cho, Kwang Yun

    2005-05-01

    A series of 3-chloro-2-(4-chloro-2-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazole derivatives containing various substituted isoxazolinylmethoxy groups at the 5-position of the benzene ring were synthesized and their herbicidal activities assessed under greenhouse and flooded paddy conditions. Among them, compounds having a phenyl or cyano substituent at the 3-position of the 5-methyl-isoxazolin-5-yl structure demonstrated good rice selectivity and potent herbicidal activity against annual weeds at 16-63 g AI ha(-1) under greenhouse conditions. Field trials indicated that these two compounds controlled a wide range of annual weeds rapidly with a good tolerance on transplanted rice seedlings by pre-emergence application. They showed a low mammalian and environmental toxicity in various toxicological tests. PMID:15627239

  3. Magnetic Behavior of Pr55Cu13.3Ni6.7Al25 Metallic Glasses

    NASA Astrophysics Data System (ADS)

    Gao, Y. P.; Gao, S. B.; Yu, P. F.; Feng, S. D.; Li, G.; Liaw, P. K.; Liu, R. P.

    2015-06-01

    Owing to their unique electronic structures of rare-earth elements, the electric and magnetic properties of the rare-earth-based metallic glasses (MGs) are especially addressed. The magnetic properties of the Pr55Cu13.3Ni6.7Al25 MGs prepared in the shape of a rod up to 3 mm in diameter by suction casting were researched. Under the glass-transition temperature in the range of 373 K to 501 K (100 °C to 228 °C), annealed 3 hours, the MG expressed the soft-magnetic behavior. At the high temperature of 501 K (228 °C), it was found that the alloy changed from the soft-magnetic to hard-magnetic behavior, and the coercivity of the alloy increases with crystallization. The new nonmagnetic rare-earth-based MG offers an ideal material for studying the magnetic behavior.

  4. Special Awareness Month.

    ERIC Educational Resources Information Center

    Granstrom, Jane; And Others

    1982-01-01

    The article reports on the organization and implementation of a "Special Needs Awareness Month" in Quincy, Massachusetts. Noted are the heavy involvement of parents in the multiagency planning committee, and the resulting citywide displays, publications, programs, and publicity on children with special needs. (DB)

  5. Monthly Energy Review

    EIA Publications

    2016-01-01

    The Monthly Energy Review (MER) is the U.S. Energy Information Administration's primary report of recent energy statistics. Included are total energy production, consumption, and trade; energy prices; overviews of petroleum, natural gas, coal, electricity, nuclear energy, renewable energy, and international petroleum; carbon dioxide emissions; and data unit conversions.

  6. November 2010 monthly report

    SciTech Connect

    Neff, Warren E

    2010-12-07

    These viewgraphs are to be provided to NNSA to update the status of the B61 Life Extension Project work and activities. The viewgraphs cover such issues as budget, schedule, scope, and the like. They are part of the monthly reporting process.

  7. Electric Power Monthly

    EIA Publications

    2016-01-01

    Provides monthly statistics at the state, Census division, and U.S. levels for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of fossil fuels, electricity sales, revenue, and average revenue per kilowatthour of electricity sold.

  8. Monthly energy review

    SciTech Connect

    1997-12-01

    This document presents an overview of the Energy Information Administration`s (EIA) recent monthly energy statistics. The statistics cover the major activities of U.S. production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors.

  9. Monthly Energy Review

    SciTech Connect

    1996-05-28

    This publication presents an overview of the Energy information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. Two brief ``energy plugs`` (reviews of EIA publications) are included, as well.

  10. Black History Month.

    ERIC Educational Resources Information Center

    Web Feet K-8, 2000

    2000-01-01

    This annotated subject guide to Web sites and additional resources focuses on Black History month. Specifies age levels for resources that include Web sites, CD-ROMs and software, videos, books, audios, magazines; includes professional resources; and presents a relevant class activity. (LRW)

  11. Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase.

    PubMed

    Fischer, Markus; Haase, Ilka; Kis, Klaus; Meining, Winfried; Ladenstein, Rudolf; Cushman, Mark; Schramek, Nicholas; Huber, Robert; Bacher, Adelbert

    2003-02-21

    6,7-Dimethyl-8-ribityllumazine synthase (lumazine synthase) catalyses the penultimate step in the biosynthesis of riboflavin. In Bacillus subtilis, 60 lumazine synthase subunits form an icosahedral capsid enclosing a homotrimeric riboflavin synthase unit. The ribH gene specifying the lumazine synthase subunit can be expressed in high yield. All amino acid residues exposed at the surface of the active site cavity were modified by PCR assisted mutagenesis. Polar amino acid residues in direct contact with the enzyme substrates, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione and 3,4-dihydroxy-2-butanone 4-phosphate, could be replaced with relative impunity with regard to the catalytic properties. Only the replacement of Arg127, which forms a salt bridge with the phosphate group of 3,4-dihydroxy-2-butanone 4-phosphate, reduced the catalytic rate by more than one order of magnitude. Replacement of His88, which is believed to assist in proton transfer reactions, reduced the catalytic activity by about one order of magnitude. Surprisingly, the activation enthalpy deltaH of the lumazine synthase reaction exceeds that of the uncatalysed reaction. On the other hand, the free energy of activation deltaG of the uncatalysed reaction is characterised by a large entropic term (TdeltaS) of -37.8 kJmol(-1), whereas the entropy of activation (TdeltaS) of the enzyme-catalysed reaction is -6.7 kJmol(-1). This suggests that the rate enhancement by the enzyme is predominantly achieved by establishing a favourable topological relation of the two substrates, whereas acid/base catalysis may play a secondary role. PMID:12581640

  12. Synthesis and anticancer activities of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline derivatives.

    PubMed

    Zhang, Ying; Huang, Yin-Jiu; Xiang, Hong-Mei; Wang, Pei-Yi; Hu, De-Yu; Xue, Wei; Song, Bao-An; Yang, Song

    2014-05-01

    A series of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline was prepared by conventional heating methods. Among these compounds, the crystal structure of compound 10o (CCDC: 916922) was determined by X-ray crystallography. Bioassay results showed that most target compounds had certain inhibition activities against proliferation of tumor cells, and some compounds even had good broad-spectrum inhibition activities. The ethoxyl series of compounds possessed higher inhibition activities against tumor cells than the methoxyl series of compounds. Bioactivity tests showed that the IC50 values of compound 10s against PC3, MGC803, A375, and A549 cells were 1.8, 2.8, 1.3, and 2.9 μΜ, respectively, which were much higher than those of commercial gefitinib (7.2, 7.6, 7.2, and 9.8 μM, respectively). Conversely, the IC50 values of compound 10s were very low against NH3T3, indicating only weak effect on normal cells as also proven by lactate dehydrogenase and acridine orange/ethidium bromide staining. Analyses of cell configuration and cell cycle revealed that compound 10s possibly caused cells to remain at G0/G1 phase by inhibiting cell proliferation for 24 h. Compound 10s also inhibited the phosphorylation of ERK1/2 and P38 with obvious concentration dependence. Thus, these compounds can inhibit the proliferation of A549 cells through the interruption of ERK1/2 and P38signaling pathways. PMID:24675177

  13. Redislocation After a Failed Surgery to Treat C6/7 Fracture-Dislocation With Pedicular Fracture of the C6 Vertebra: Case Report of a Successful Revision Surgery, Analysis of the Causes, and Discussion of Revision Surgical Strategies.

    PubMed

    Yang, Yi; Ma, Litai; Li, Tao; Liu, Hao

    2016-03-01

    Cervical spinal fracture-dislocation with pedicular fracture of the vertebra has been little reported and the management of such a patient is difficult. Considering the little knowledge of this area, we present this special case of a successful revision surgery for the treatment of redislocation after a failed surgery to treat C6/7 fracture-dislocation with pedicular fracture of the C6 vertebra to share our experience.A 45-year-old male patient presented to our hospital with history of neck pain for 4 months. According to his medical records, he was involved in an architectural accident and diagnosed with C6/7 fracture-dislocation with pedicular fracture of the C6 vertebra (ASIA: D). A surgery of posterior lateral mass screw fixation (bilateral in C5 and C7; left side in C6) was performed in a different institution. However, 4 months after his primary surgery, he was still troubled by serious neck pain and muscle weakness in all right side limbs. The physical examination of the patient showed hypoesthesia in the right side limbs, myodynamia of the right side limbs weakened to Grade 4. Cervical X-rays, computed tomography (CT), and magnetic resonance imaging confirmed the redislocation of C6/7. A successful revision surgery of anterior cervical corpectomy and fusion (ACCF) with nanohydroxyapatite/polyamide 66 composite fulfilled with vertebral autograft plus anterior plate was performed. The 3 months postoperative X-rays and CT scan showed the good position of the implant and bony fusion. The patient's neck pain was relived and the neurological function recovered to ASIA E grade at the 3rd month follow-up.ACCF with nanohydroxyapatite/polyamide 66 composite fulfilled with vertebral autograft plus anterior plate is effective for the treatment of redislocation after a failed surgery in patients of fracture-dislocation with pedicular fracture. The best method to avoid such a failed surgery is a combined anterior-posterior approach surgery in our opinion. PMID:26962843

  14. Treatment of atherosclerosis in apolipoprotein E-deficient mice with 4-(3-Bromobenzoyl)-6,7-dimethoxyquinazoline (WHI-P164), a potent inhibitor of triglyceride synthesis.

    PubMed

    Trieu, V N; Liu, X P; Chen, C L; Uckun, F M

    2000-02-01

    We identified a novel organic compound, 4-(3'-bromobenzoyl)-6,7-dimethoxyquinazoline (compound WHI-P164), as a potent inhibitor of triglyceride (TG) synthesis. In an in vitro model of lipid synthesis, WHI-P164 (but not any one of the three structurally similar control dimethoxyquinazoline compounds) inhibited the accumulation of TG-rich intracellular lipid droplets in Caco-2 human intestinal cells in a concentration-dependent fashion. WHI-P164 caused no acute toxicity associated with morbidity or mortality in mice when administered at dose levels ranging from 0.5 to 80 mg/kg. In pharmacokinetic studies in mice, WHI-P164 was rapidly eliminated from plasma with a terminal elimination half-life of 26.1 +/- 1.3 min after intraperitoneal administration and 33.3 +/- 11.3 min after intravenous administration. Treatment with 40 mg/kg WHI-P164 (but not one of three structurally similar control dimethoxyquinazoline compounds) administered intraperitoneally once daily for 7 consecutive treatment days blocked the in vivo hepatic TG synthesis in both apoE-deficient and wild-type C57B1/6 mice. In apoE-deficient mice maintained on a high-fat/high-cholesterol Western diet, WHI-P164 substantially reduced the lipid accumulation in the liver after 7 days of treatment and the lipid accumulation in the aorta after 1 month of treatment. Our results in apoE-deficient mice show that lipid accumulation in hepatocytes and foam cells are related events, and inhibiting TG synthesis with WHI-P164 offers an effective means to treat atherosclerosis. PMID:10672848

  15. Petroleum marketing monthly

    SciTech Connect

    1996-02-01

    The Petroleum Marketing Monthly (PMM) provides information and statistical data on a variety of crude oils and refined petroleum products. The publication presents statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners acquisition cost of crude oil. Refined petroleum product sales data include motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane. The Petroleum Marketing Division, Office of Oil and Gas, Energy Information Administration ensures the accuracy, quality, and confidentiality of the published data in the Petroleum Marketing Monthly.

  16. Petroleum marketing monthly

    SciTech Connect

    1996-07-01

    Petroleum Marketing Monthly (PPM) provides information and statistical data on a variety of crude oils and refined petroleum products. The publication presents statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o. b. and landed cost of imported crude oil, and the refiners` acquisition cost of crude oil. Refined petroleum product sales data include motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane. The Petroleum Marketing Division, Office of Oil and Gas, Energy Information Administration ensures the accuracy, quality, and confidentiality of the published data in the Petroleum Marketing Monthly.

  17. Petroleum marketing monthly

    SciTech Connect

    1995-08-01

    The Petroleum Marketing Monthly (PMM) provides information and statistical data on a variety of crude oils and refined petroleum products. The publication presents statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners` acquisition cost of crude oil. Refined petroleum product sales data include motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane. The Petroleum Marketing Division, Office of Oil and Gas, Energy Information Administration ensures the accuracy, quality, and confidentiality of the published data in the Petroleum Marketing Monthly.

  18. Electric power monthly

    SciTech Connect

    1995-08-01

    The Energy Information Administration (EIA) prepares the Electric Power Monthly (EPM) for a wide audience including Congress, Federal and State agencies, the electric utility industry, and the general public. This publication provides monthly statistics for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of fossil fuels, electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Data on net generation, fuel consumption, fuel stocks, quantity and cost of fossil fuels are also displayed for the North American Electric Reliability Council (NERC) regions. The EIA publishes statistics in the EPM on net generation by energy source, consumption, stocks, quantity, quality, and cost of fossil fuels; and capability of new generating units by company and plant. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead.

  19. Electric power monthly

    SciTech Connect

    Smith, Sandra R.; Johnson, Melvin; McClevey, Kenneth; Calopedis, Stephen; Bolden, Deborah

    1992-05-01

    The Electric Power Monthly is prepared by the Survey Management Division; Office of Coal, Nuclear, Electric and Alternate Fuels, Energy Information Administration (EIA), Department of Energy. This publication provides monthly statistics at the national, Census division, and State levels for net generation, fuel consumption, fuel stocks, quantity and quality of fuel, cost of fuel, electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Data on net generation, fuel consumption, fuel stocks, quantity and cost of fuel are also displayed for the North American Electric Reliability Council (NERC) regions. Additionally, statistics by company and plant are published in the EPM on capability of new plants, new generation, fuel consumption, fuel stocks, quantity and quality of fuel, and cost of fuel.

  20. STATISTICAL PROPERTIES OF 12.2 GHz METHANOL MASERS ASSOCIATED WITH A COMPLETE SAMPLE OF 6.7 GHz METHANOL MASERS

    SciTech Connect

    Breen, S. L.; Caswell, J. L.; Green, J. A.; Voronkov, M. A.; Ellingsen, S. P.; Fuller, G. A.; Quinn, L. J.; Avison, A.

    2011-06-01

    We present definitive detection statistics for 12.2 GHz methanol masers toward a complete sample of 6.7 GHz methanol masers detected in the Methanol Multibeam survey south of declination -20{sup 0}. In total, we detect 250 12.2 GHz methanol masers toward 580 6.7 GHz methanol masers. This equates to a detection rate of 43.1%, which is lower than that of previous significant searches of comparable sensitivity. Both the velocity ranges and the flux densities of the target 6.7 GHz sources surpass that of their 12.2 GHz companion in almost all cases. Eighty percent of the detected 12.2 GHz methanol maser peaks are coincident in velocity with the 6.7 GHz maser peak. Our data support an evolutionary scenario whereby the 12.2 GHz sources are associated with a somewhat later evolutionary stage than the 6.7 GHz sources devoid of this transition. Furthermore, we find that the 6.7 GHz and 12.2 GHz methanol sources increase in luminosity as they evolve. In addition to this, evidence for an increase in velocity range with evolution is presented. This implies that it is not only the luminosity but also the volume of gas conducive to the different maser transitions that increases as the sources evolve. Comparison with GLIMPSE mid-infrared sources has revealed a coincidence rate between the locations of the 6.7 GHz methanol masers and GLIMPSE point sources similar to that achieved in previous studies. Overall, the properties of the GLIMPSE sources with and without 12.2 GHz counterparts are similar. There is a higher 12.2 GHz detection rate toward those 6.7 GHz methanol masers that are coincident with extended green objects.

  1. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  2. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  3. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  4. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  5. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  6. Periodized wavelets

    SciTech Connect

    Schlossnagle, G.; Restrepo, J.M.; Leaf, G.K.

    1993-12-01

    The properties of periodized Daubechies wavelets on [0,1] are detailed and contrasted against their counterparts which form a basis for L{sup 2}(R). Numerical examples illustrate the analytical estimates for convergence and demonstrate by comparison with Fourier spectral methods the superiority of wavelet projection methods for approximations. The analytical solution to inner products of periodized wavelets and their derivatives, which are known as connection coefficients, is presented, and several tabulated values are included.

  7. Developmental milestones record - 9 months

    MedlinePlus

    Growth milestones for children - 9 months; Childhood growth milestones - 9 months; Normal childhood growth milestones - 9 months ... pushed to encourage walking. Sing songs together. Avoid television time until age 2. Try using a transition ...

  8. Natural gas monthly, February 1998

    SciTech Connect

    1998-02-01

    This issue of the Natural Gas Monthly (NGM) presents the most recent estimates of natural gas data from the Energy Information Administration. Estimates extend through February 1998 for many data series, and through November 1997 for most natural gas prices. Highlights of the natural gas data contained in this issue are: Preliminary estimates for January and February 1998 show that dry natural gas production, net imports, and consumption are all within 1 percent of their levels in 1997. Warmer-than-normal weather in recent months has resulted in lower consumption of natural gas by the residential sector and lower net withdrawals of gas from under round storage facilities compared with a year ago. This has resulted in an estimate of the amount of working gas in storage at the end of February 1998 that is 18 percent higher than in February 1997. The national average natural gas wellhead price is estimated to be $3.05 per thousand cubic feet in November 1997, 7 percent higher than in October. The cumulative average wellhead price for January through November 1997 is estimated to be $2.42 per thousand cubic feet, 17 percent above that of the same period in 1996. This price increase is far less than 36-percent rise that occurred between 1995 and 1996. 6 figs., 26 tabs.

  9. Petroleum marketing monthly

    SciTech Connect

    1995-11-01

    The Petroleum Marketing Monthly (PMM) provides information and statistical data on a variety of crude oils and refined petroleum products. The publication presents statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners` acquisition cost of crude oil. Refined petroleum product sales data include motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane. The Petroleum Marketing Division, Office of Oil and Gas, Energy Information Administration ensures the accuracy, quality, and confidentiality of the published data.

  10. Comprehensive Synthesis of Monohydroxy-Cucurbit[n]urils (n = 5, 6, 7, 8): High Purity and High Conversions.

    PubMed

    Ayhan, Mehmet M; Karoui, Hakim; Hardy, Micaël; Rockenbauer, Antal; Charles, Laurence; Rosas, Roselyne; Udachin, Konstantin; Tordo, Paul; Bardelang, David; Ouari, Olivier

    2015-08-19

    We describe a photochemical method to introduce a single alcohol function directly on cucurbit[n]urils (n = 5, 6, 7, 8) with conversions of the order 95-100% using hydrogen peroxide and UV light. The reaction was easily scaled up to 1 g for CB[6] and CB[7]. Spin trapping of cucurbituril radicals combined with MS experiments allowed us to get insights about the reaction mechanism and characterize CB[5], CB[6], CB[7], and CB[8] monofunctional compounds. Experiments involving (18)O isotopically labeled water indicated that the mechanism was complex and showed signs of both radical and ionic intermediates. DFT calculations allowed estimating the Bond Dissociation Energies (BDEs) of each hydrogen atom type in the CB series, providing an explanation of the higher reactivity of the "equatorial" C-H position of CB[n] compounds. These results also showed that, for CB[8], direct functionalization on the cucurbituril skeleton is more difficult because one of the methylene hydrogen atoms (Hb) has its BDE lowering within the series and coming close to that of Hc, thus opening the way to other types of free radicals generated on the CB[8] skeleton leading to several side products. Yet CB[5]-(OH)1 and CB[8]-(OH)1, the first CB[8] derivative, were obtained in excellent yields thanks to the soft method presented here. PMID:26197228

  11. Design, synthesis and pharmacological evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents.

    PubMed

    Zhou, Shunguang; Ren, Jianguo; Liu, Mingmei; Ren, Lixiang; Liu, Yajing; Gong, Ping

    2014-12-01

    Two series of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 2,4-imidazolinedione/pyrazolone scaffold were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against HT-29, H460, A549, MKN-45, and U87MG cancer cell lines in vitro. The pharmacological data indicated that most of the tested compounds showed moderate to significant cytotoxicity and high selectivity against HT-29, H460 and A549 cancer cell lines as compared with foretinib. The SAR analyses indicated that compounds with halogen groups, especially trifluoromethyl groups at 2-position on the phenyl ring (moiety B) were more effective. In this study, a promising compound 17 (c-Met IC50=2.20nM, a multi-target tyrosine kinase inhibitor) showed the most potent antitumor activities with IC50 values of 0.14μM, 0.18μM, 0.09μM, 0.03μM, and 1.06μM against HT-29, H460, A549, MKN-45, and U87MG cell lines, respectively. PMID:25173590

  12. Source model for the Mw 6.7, 23 October 2002, Nenana Mountain Earthquake (Alaska) from InSAR

    USGS Publications Warehouse

    Wright, Tim J.; Lu, Zhong; Wicks, Chuck

    2003-01-01

    The 23 October 2002 Nenana Mountain Earthquake (Mw ∼ 6.7) occurred on the Denali Fault (Alaska), to the west of the Mw ∼ 7.9 Denali Earthquake that ruptured the same fault 11 days later. We used 6 interferograms, constructed using radar images from the Canadian Radarsat-1 and European ERS-2 satellites, to determine the coseismic surface deformation and a source model. Data were acquired on ascending and descending satellite passes, with incidence angles between 23 and 45 degrees, and time intervals of 72 days or less. Modeling the event as dislocations in an elastic half space suggests that there was nearly 0.9 m of right-lateral strike-slip motion at depth, on a near-vertical fault, and that the maximum slip in the top 4 km of crust was less than 0.2 m. The Nenana Mountain Earthquake increased the Coulomb stress at the future hypocenter of the 3 November 2002, Denali Earthquake by 30–60 kPa.

  13. Synthesis and anticancer activities of 5,6,7-trimethoxy-N-phenyl(ethyl)-4-aminoquinazoline derivatives.

    PubMed

    Zhang, Ying; Jin, Linhong; Xiang, Hongmei; Wu, Jian; Wang, Peiyi; Hu, Deyu; Xue, Wei; Yang, Song

    2013-08-01

    A series of 5,6,7-trimethoxy-N-phenyl(ethyl)-4-aminoquinazoline compounds was prepared by microwave irradiation and conventional heating methods. Compounds 6p, 6q, and 6x strongly inhibited extracellular regulated kinase1/2 (ERK1/2) phosphorylation induced by epidermal growth factor (EGF) at 1.28 μM in PC3 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that all compounds had certain anticancer activities, and the IC₅₀ values of 6x were 6.2 ± 0.9, 3.2 ± 0.1, and 3.1 ± 0.1 μM against PC3, BGC823, and Bcap37 cells, respectively. Acridine orange/ethidium bromide staining, Hoechst 33258 staining, DNA ladder, and flow cytometry analyses revealed that 6x induced cell apoptosis in PC3 cells, with apoptosis ratios of 11.6% at 1 μM and 31.8% at 10 μM after 72 h. PMID:23811258

  14. Studying the Sequence of the April 17, 2003 Delingha Earthquake (ML=6.7) by Regional Moment Tensor Inversion

    NASA Astrophysics Data System (ADS)

    Jiao, W.; Qian, R.; Chan, W.; Zeng, X.; Zhang, M.

    2004-12-01

    On April 17, 2003, a strong earthquake of ML = 6.7 occurred to the northwest of the Delingha City, Qinghai Province, northwest China. The epicenter (37o33¡_N, 96o27¡_E) lies in the Zongwulong Mountain, where the Dachaidan-Zongwulong Mountain fault (DZMF) zone runs through. In this study, we analyzed the focal mechanism of the main shock and several strong immediate aftershocks by regional waveform moment tensor inversion. We collected a comprehensive regional waveform data set that includes the broadband waveforms from the China Digital Seismic Network, the GSN, and a portable broadband seismic network deployed in the near regional distance to the earthquake at the time. One very broadband station equipped with the STS-2 seismometer and 24-bit digital data logger was only 80km from the epicenter, which gave tremendous constraint on the mechanism of the aftershock sequence (Fan and Wallace, 1991; Dreger and Helmberger, 1993). Our results show the dominance of the high angle thrust faulting striking NWW-NW. The distribution of the fault plane solutions reflects the turning and/or branching of the DZMF zone in the area, which has been confirmed by the field geological survey.

  15. MISSE 6, 7 and 8 Materials Sample Experiments from the International Space Station Materials and Processes Team

    NASA Technical Reports Server (NTRS)

    Kravchenko, Michael; ORourke, Mary Jane; Golden, Johnny; Finckenor, Miria; Leatherwood, Michael; Alred, John

    2010-01-01

    The International Space Station Materials and Processes (ISS M&P) team has multiple material samples on MISSE 6, 7 and 8 to observe Low Earth Orbit (LEO) environmental effects on Space Station materials. Optical properties, thickness/mass loss, surface elemental analysis, visual and microscopic analysis for surface change are some of the techniques employed in this investigation. The ISS M&P team has participated in previous MISSE activities in order to better characterize the LEO effects on Space Station materials. This investigation will further this effort. Results for the following MISSE 6 samples materials will be presented: a comparison of anodize and chemical conversion coatings on various aluminum alloys, electroless nickel; AZ93 white ceramic thermal control coating with and without Teflon; Hyzod(TM) polycarbonate used to temporarily protect ISS windows; Russian quartz window material; reformulated Teflon (TM) coated Beta Cloth (Teflon TM without perfluorooctanoic acid (PFOA)) and a Dutch version of beta cloth. Discussion for current and future MISSE materials experiments will be presented. MISSE 7 samples are: deionized water sealed anodized aluminum Photofoil(TM); indium tin oxide (ITO)- coated Kapton(TM) used as thermo-optical surfaces; mechanically scribed tin-plated beryllium-copper samples for "tin pest" growth ( alpha/Beta transformation); Crew Exploration Vehicle (CEV) parachute soft goods. MISSE 8 sample: exposed "scrim cloth" (fiberglass weave) from the ISS solar array wing material, Davlyn fiberglass sleeve material, Permacel and Intertape protective tapes, and ITO-coated Kapton.

  16. Gridded monthly temperatures over Italy

    NASA Astrophysics Data System (ADS)

    Fioravanti, G.; Toreti, A.; Fraschetti, P.; Perconti, W.; Desiato, F.

    2010-09-01

    Temperature data represent a relevant source of information for environmental modelling, which usually relies on the availability of regularly distributed datasets. The CRU and the E-OBS archives are two examples of large-scale gridded products available for temperature. In order to fill the gap of having such a dataset freely available at national level, a high resolution (1 km) dataset for the whole Italian territory has been realized, made up of gridded monthly mean temperatures over Italy from 1961 to 2008. Available temperature data are provided by several national and regional networks and are consequently rather discontinuous in time and inhomogeneous in space. For this reason, our approach is based on the use of all data available for each month; this choice limits the consistency of gridded temperatures as time series but guarantees the best possible spatial estimate for each time period. The space interpolation was implemented by means of regression-kriging, a well-known geostatistical approach. Regression kriging is a variant of kriging interpolation which allows to exploit the auxiliary information provided by external variables. In this work, altitude and latitude of the input weather stations were found to be strongly correlated with temperature data and used as independent variables in the regression model. Ordinary kriging was then applied to describe the spatial correlation structure of the regression residuals. For each map, the most appropriate variogram function was estimated by means of an objective algorithm. In order to evaluate the quality of each interpolated surface, a cross validation analysis was performed, whose results were evaluated in terms of root mean square error, mean absolute error and mean squared deviation ratio. RMSE ranges between 1.0 and 1.5 °C, and improves, as expected, over the last years when a greater number of stations are available. The RMSE as function of the season was investigated as well. The monthly maps were

  17. Periodic cages.

    PubMed

    Diudea, Mircea V; Nagy, Csaba L; Silaghi-Dumitrescu, Ioan; Graovac, Ante; Janezic, Dusanka; Vikić-Topić, Drazen

    2005-01-01

    Various cages are constructed by using three types of caps: f-cap (derived from spherical fullerenes by deleting zones of various size), kf-cap (obtainable by cutting off the polar ring, of size k), and t-cap ("tubercule"-cap). Building ways are presented, some of them being possible isomerization routes in the real chemistry of fullerenes. Periodic cages with ((5,7)3) covering are modeled, and their constitutive typing enumeration is given. Spectral data revealed some electronic periodicity in fullerene clusters. Semiempirical and strain energy calculations complete their characterization. PMID:15807490

  18. Ontogenic profile of seizures evoked by the beta-carboline DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in rats

    PubMed Central

    Kulick, Catherine; Gutherz, Samuel; Kondratyev, Alexei; Forcelli, Patrick A.

    2014-01-01

    The beta-carboline, methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate (DMCM), is a potent chemoconvulsant. While it has been utilized in adult rodents, it has not been previously examined for effects across postnatal development. DMCM is a negative allosteric modulator of benzodiazepine-sensitive GABAA receptors, receptor subtypes that are particularly enriched in limbic brain regions. This raises the possibility that DMCM may be particularly effective at evoking forebrain seizures, which is a challenge in neonatal animals due to the relative immaturity of the forebrain seizure network. The ability to selectively evoke forebrain seizures is desirable when screening for drugs to use in temporal lobe epilepsy, which is characterized by seizures within the forebrain (limbic) network. To determine the profile of DMCM action across development, we examined the dose-dependent ability of DMCM to induce seizures in rats at P7, P10, P13, P14, P21 and in adulthood. We found that the highest sensitivity to DMCM occurred in P10, P13, and P14 rats. The lowest sensitivity occurred in P21 rats. Neonatal (P7) and adult (P60+) rats displayed moderate sensitivity. With moderate (0.2–0.4mg/kg) doses of DMCM, we were able to reliably evoke limbic motor seizures without tonic-clonic components in animals as young as P7. These data support the utility of DMCM in assessing seizure threshold during development and raise the possibility for future exploration of DMCM as an agent to screen anticonvulsant drugs during the postnatal period. PMID:24967532

  19. Body weights at weaning and 18 months of Zebu, Brown Swiss, Charolais and crossbred heifers in south-east Mexico.

    PubMed

    Magaña, J G; Segura-Correa, J C

    2006-02-01

    The objective of this study was to evaluate the body weights up to 18 months of age of 12 breed groups of Zebu (Z), Brown Swiss (BS) and Charolais heifers (CH), and their crosses under tropical conditions. A total of 1434 data on weaning weights adjusted to 240 days (WW8), average daily gain to 240 days (ADG8) and 1025 body weights adjusted to 550 days (BW18) and average postweaning daily gain (ADG18) of heifers born from 1981 to 1995 were used. Cows and calves remained together from birth to weaning and grazed on Guinea grass (Panicum maximum). Years of birth were grouped in three periods, because of the small numbers of observations per year (1981-85, 1986-90 and 1991-95). Similarly, months of birth were grouped in three seasons: dry (February to May), rainy (June to September) and windy and rainy (October to January). Ages of dams were classified in six groups (6, 7 and >or=8 years). Breed groups were animals with 12.5%, 25.0%, 50.0%, 62.5%, 75.0% and 100% BS genes and 25.0%, 50.0%, 75.0% and 100% CH genes and also Z and undefined crossbred animals. Data were analysed using a fixed model that included effects of period, and season of birth, age of dam and breed group of heifer. Analyses of variance showed significant (p < 0.05) effects of period, season and breed group for all traits. However, parity was significant (p < 0.05) only for WW8 and ADG8. Interactions among main factors were not significant (p > 0.05). Z heifers gained the least weight to weaning but were similar to BS at 18 months of age. CH were heavier at 18 months of age than BS heifers, but not at weaning. Body weights at 18 months of age of 1/8 and 1/4 BS crossbred heifers were similar (p > 0.05) and lower than F1 (BS x Z) (p < 0.05); however, the later and higher grades of BS had the highest body weights at 18 months of age and were similar to CH and 1/4 CH x 3/4 Z heifers. Undefined crossbred heifers had better performance than the Z breed group. Environmental factors were

  20. Fermi at Six Months

    NASA Technical Reports Server (NTRS)

    Hays, Elizabeth

    2009-01-01

    An overview of the Fermi Gamma-ray Space Telescope's first 6 months in operation is provided. The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy rage 20 MeV to more than 300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. It contains a Large Area Telescope capable of viewing the entire sky every 3 hours and a Gamma-ray Burst Monitor for viewing the entire unocculted sky. Since its launch on June 11, 2008 Fermi has provided information on pulsars, gamma ray bursts, relativistic jets, the active galactic nucleus, and a globular star cluster. This presentation describes Fermi's development, mission, instruments and recent findings.

  1. COSMIC monthly progress report

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Activities of the Computer Software Management and Information Center (COSMIC) are summarized for the month of April 1994. Tables showing the current inventory of programs available from COSMIC are presented and program processing and evaluation activities are summarized. Five articles were prepared for publication in the NASA Tech Brief Journal. These articles (included in this report) describe the following software items: GAP 1.0 - Groove Analysis Program, Version 1.0; SUBTRANS - Subband/Transform MATLAB Functions for Image Processing; CSDM - COLD-SAT Dynamic Model; CASRE - Computer Aided Software Reliability Estimation; and XOPPS - OEL Project Planner/Scheduler Tool. Activities in the areas of marketing, customer service, benefits identification, maintenance and support, and disseminations are also described along with a budget summary.

  2. 6.7% practice family planning. Findings of a baseline survey of knowledge, attitudes and practice in a Tanzanian village.

    PubMed

    Mpangile, G S

    1991-12-01

    This article contains the findings of a 1990 knowledge, attitude, and practice (KAP) survey conducted in Mgeta, a subdivision of the rural district of Morogoro, Tanzania. The Family Planning Association of Tanzania (UMATI) carried out the survey with the goal of obtaining baseline information with which to measure the success of an Integrated Family Planning, Nutrition, and Parasite Control (IP) Project, scheduled to be introduced in Mgeta following the survey. UMATI interviewed 310 people (113 males and 197 females) from Mgeta, who comprised 5% of the total target population. The majority of the respondents were between the ages of 20-45, had completed primary education, and made a living from farming. They were also predominantly Roman Catholic. With 4/5 of the respondents already having at least 1 child, the average number of preferred children was 6. 16.5% of the respondents reported that they or their partner had undergone at least 1 abortion. 1/3 (104) of the respondents were aware of a method--modern or otherwise--for preventing unwanted pregnancies. But only 13.8%of all those surveyed (41.3% of those who were aware of family planning) had ever used contraception, and only 6.7% of all the respondents were using contraception at the time of the survey. Despite the low contraceptive prevalence, the overwhelming majority of those with knowledge of family planning believed it is important for improving family and child health, and that is not contrary to their religious beliefs. These findings suggest that in addition to raising awareness, communication programs must also emphasize motivation. The survey also highlights the problem of abortion, which is more widely practiced than contraception, and reveals a positive attitude towards family planning. PMID:12284677

  3. Tracking a CME from Cradle to Grave: A Multi-wavelength Analysis of the February 6-7, 1997 Event

    NASA Astrophysics Data System (ADS)

    Gopalswamy, N.; Kundu, M. R.; Hanaoka, Y.; Kosugi, T.; Hudson, H.; Nitta, N.; Thompson, B.; Gurman, J.; Plunkett, S.; Howard, R.; Burkepile, J.

    1997-05-01

    The partially earth-directed coronal mass ejection (CME) event of 1997 February 6-7 originated from the southwest quadrant of the sun. The CME accelerated from 170 km/s to about 830 km/s when it reached a distance of 25 solar radii. The CME was an arcade eruption followed by bright prominence core structures. The prominence core was tracked continuously from the solar surface to the interplanetary medium by combining data from the Nobeyama radioheliograph (microwaves), Mauna Loa Solar Observatory (He 10830 { Angstroms}), SOHO/EIT (EUV) and SOHO/LASCO (white light). The CME was accompanied by an arcade formation, fully observed by the YOHKOH/SXT (soft X-rays) and SOHO/EIT (EUV). The X-ray and EUV observations suggest that the reconnection proceeded from the northwest end to the southeast end of a filament channel. In the SOHO/EIT images, the the feet of the soft X-ray arcade were observed as EUV ribbons. The CME event also caused a medium sized geomagnetic storm: The hourly equatorial Dst values attained storm level during 18:00-19:00 UT on February 09. This means the disturbance took about 2.25 days to reach the Earth. The first signatures of an IP shock was a pressure jump in the WIND data around 13:00 UT on Feb 09, 1997 which lasted for about 14 hours, followed by flux rope signatures. This CME event confirms a number of ideas about CMEs: The three part structure (frontal bright arcade, dark cavity and prominence core), disappearing filament, elongated arcade formation, and terrestrial effects. We make use of the excellent data coverage from the solar surface to the Earth to address a number of issues regarding the origin and propagation of the geoeffective solar disturbances. We benefited from discussions at the first SOHO-Yohkoh Coordinated Data Analysis Workshop, held March 3-7, 1997, at Goddard Space Flight Center.

  4. 6,7-disubstituted 2,4-diaminopteridines: novel inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.

    PubMed Central

    Jackson, H C; Biggadike, K; McKilligin, E; Kinsman, O S; Queener, S F; Lane, A; Smith, J E

    1996-01-01

    Four novel, disubstituted diaminopteridines have been identified which antagonize the uptake of a folate precursor (para-aminobenzoic acid) by rat-derived Pneumocystis carinii maintained in short-term axenic culture at concentrations ranging from 4.5 to 26 microM. The compounds were at least 10 to 100 times more active than trimethoprim in this assay. None of these entities exhibited toxicity to mammalian cell lines at < 100 microM. The same structures also caused significant inhibition of Toxoplasma gondii tachyzoite replication within Madin-Darby bovine kidney cells at concentrations ranging from 0.1 to 10 microM. Three of the structures (GR92754, AH10639, and AH2504) were at least an order of magnitude more potent than the standard anti-T. gondii agent, pyrimethamine. All three entities were also significantly more potent and selective than pyrimethamine as inhibitors of T. gondii dihydrofolate reductase (DHFR), with 50% inhibitory concentrations within the range of 0.018 to 0.033 microM. One of these compounds, 6,7-dibutyl-2,4-diaminopteridine (GR92754), was also a potent and selective inhibitor of P. carinii DHFR (50% inhibitory concentration, 0.082 microM). GR92754 is the first DHFR inhibitor described that exhibits greater potency, selectivity, and intracellular activity against both organisms than any of the DHFR agents used clinically, namely, trimethoprim, pyrimethamine, and trimetrexate. This information could provide the starting point for examination of the pharmacokinetic and therapeutic potential of GR92754 and related chemical entities with animal models. PMID:8726003

  5. Contribution of the 6.7 keV Emission line from Stellar Flares to the Galactic Ridge X-ray Emission

    NASA Astrophysics Data System (ADS)

    Nwachukwu Eze, Romanus; Eze, Ambrose; Nwafor, Jude; Esaenwi, Sudum; Okeke, Pius; Ebisawa, Ken; Smith, Randall

    2015-08-01

    Stellar flares create sudden bursts of hot plasma that contain a wide range of temperatures, and are capable of generating 6.7 keV Fe XXV emission line via electronic collisional excitation. Using the measured 6.7 keV fluxes from a collection of Suzaku-observed stellar flares as a baseline, we estimate their contribution to the 6.7 keV emission line from the Galactic Ridge X-ray emission (GRXE). We modeled the extracted stellar flares’ spectra from our sources with an absorbed Bremstrahlung. We found strong 6.7 keV emission line from the extracted stellar flares’ spectra which is similar to the observed 6.7 keV emission line from the GRXE, while the 6.4 and 7.0 keV lines appear to be faint. The present result supports the earlier result that stellar flares contribute significantly to the total luminosity of the GRXE and that the GRXE luminosity could be primarily explained via hard X-ray emitting symbiotic stars (hSSs), and magnetic cataclysmic variables (mCVs), along with other white dwarf binary systems and stellar flares.

  6. Effects of a 6-month infliximab treatment on plasma levels of leptin and adiponectin in patients with rheumatoid arthritis.

    PubMed

    Derdemezis, Christos S; Filippatos, Theodosios D; Voulgari, Paraskevi V; Tselepis, Alexandros D; Drosos, Alexandros A; Kiortsis, Dimitrios N

    2009-10-01

    Patients with rheumatoid arthritis (RA) appear to have increased plasma levels of leptin and adiponectin. These adipokines may be implicated in the pathophysiology of RA. Tumour necrosis factor alpha (TNF-alpha) is a potential modulator of adipokines. The effects of long-term anti-TNF treatment on plasma levels of leptin and adiponectin are not clear. The aim of this study was to assess the effects of 6-month anti-TNF treatment (infliximab) on leptin and adiponectin plasma levels in RA patients. Thirty women with RA were included in the study. Patients with diabetes mellitus, any endocrine disorder or receiving any hypolipidemic or antidiabetic medication were not included. Thirty healthy age- and body mass index-matched women served as controls. Plasma levels of leptin and adiponectin were measured with enzyme immunoassay methods prior to and after the 6-month treatment with infliximab. Mean age and disease duration of patients were 51.8 +/- 14.4 and 12.2 +/- 6.7 years, respectively. Body weight did not change significantly over the 6-month period. Plasma levels of leptin and adiponectin were higher in patients than controls and did not change significantly after 6-month treatment. Interestingly, in the tertile of patients with the highest baseline adiponectin concentrations, adiponectin levels were significantly reduced (P < 0.05). Infliximab treatment did not change plasma levels of leptin and adiponectin after 6-month treatment in the whole study population. However, a reduction of adiponectin levels was observed in patients with higher baseline adiponectin levels. PMID:19563510

  7. Periodic Polymers

    NASA Astrophysics Data System (ADS)

    Thomas, Edwin

    2013-03-01

    Periodic polymers can be made by self assembly, directed self assembly and by photolithography. Such materials provide a versatile platform for 1, 2 and 3D periodic nano-micro scale composites with either dielectric or impedance contrast or both, and these can serve for example, as photonic and or phononic crystals for electromagnetic and elastic waves as well as mechanical frames/trusses. Compared to electromagnetic waves, elastic waves are both less complex (longitudinal modes in fluids) and more complex (longitudinal, transverse in-plane and transverse out-of-plane modes in solids). Engineering of the dispersion relation between wave frequency w and wave vector, k enables the opening of band gaps in the density of modes and detailed shaping of w(k). Band gaps can be opened by Bragg scattering, anti-crossing of bands and discrete shape resonances. Current interest is in our group focuses using design - modeling, fabrication and measurement of polymer-based periodic materials for applications as tunable optics and control of phonon flow. Several examples will be described including the design of structures for multispectral band gaps for elastic waves to alter the phonon density of states, the creation of block polymer and bicontinuous metal-carbon nanoframes for structures that are robust against ballistic projectiles and quasi-crystalline solid/fluid structures that can steer shock waves.

  8. [Periodic abstinence: its possibilities].

    PubMed

    1981-05-01

    Experience with family planning mehods requiring periodic sexual abstinence has been varied. During the last decade interest has centered on 2 methods, the cervical mucus and the sympto-thermal, which are based on identifying the onset of the fertile period. During the 1970s, the Australian physicians John and Evelyn Billings developed the cervical mucus method, in which changes in the quanitity and characteristics of cervical mucus are used to determine the moment of ovulation. The sympto-thermal method depends on identification of the slight rise in basal body temperature that occurs in the latter part of the menstrual cycle as well as cervical mucus changes and sometimes the calendar to determine the fertile period. The Catholic Church has been the main proponent of periodic abstinence methods, but since 1973 the World Health Organization has invested US$3.3 million on research in such methods. The Billings method requires differentiating between dry, wet, and very wet mucus in the vagina and between different consistencies of mucus. The method ususally requires 1-3 months for instruction and sexual abstinence is usually recommended for the 1st month. The average number of days of required abstinence was 9 in a study of 66 women and 15-18 in a study of 870 women. Many women with short menstrual cycles do not experience postmenstrual dry days, in which case abstinence may be required as many as 13 days out of 23. 18.8% of users of periodic abstinence methods in 1 North American study became pregnant in the 1st year, but most were using the calendar method. Women who desired to terminate childbearing had only about 1/2 as many failures with periodic abstinence methods as did women wishing to postpone a birth. PMID:12311397

  9. Petroleum supply monthly

    SciTech Connect

    1995-10-01

    The Petroleum Supply Monthly (PSM) is one of a family of four publications produced by the Petroleum Supply Division within the Energy Information Administration (EIA) reflecting different levels of data timeliness and completeness. The other publications are the Weekly Petroleum Status Report (WPSR), the Winter Fuels Report, and the Petroleum Supply Annual (PSA). Data presented in the PSM describe the supply and disposition of petroleum products in the United States and major US geographic regions. The data series describe production, imports and exports, inter-Petroleum Administration for Defense (PAD) District movements, and inventories by the primary suppliers of petroleum products in the United States (50 States and the District of Columbia). The reporting universe includes those petroleum sectors in primary supply. Included are: petroleum refiners, motor gasoline blends, operators of natural gas processing plants and fractionators, inter-PAD transporters, importers, and major inventory holders of petroleum products and crude oil. When aggregated, the data reported by these sectors approximately represent the consumption of petroleum products in the United States.

  10. Petroleum Supply Monthly

    SciTech Connect

    1996-02-01

    The Petroleum Supply Monthly (PSM) is one of a family of four publications produced by the Petroleum Supply Division within the Energy Information Administration (EIA) reflecting different levels of data timeliness and completeness. The other publications are the Weekly Petroleum Status Report (WPSR), the Winter Fuels Report, and the Petroleum Supply Annual (PSA). Data presented in the PSM describe the supply and disposition of petroleum products in the United States and major U.S. geographic regions. The data series describe production, imports and exports, inter-Petroleum Administration for Defense (PAD) District movements, and inventories by the primary suppliers of petroleum products in the United States (50 States and the District of Columbia). The reporting universe includes those petroleum sectors in primary supply. Included are: petroleum refiners, motor gasoline blenders, operators of natural gas processing plants and fractionators, inter-PAD transporters, importers, and major inventory holders of petroleum products and crude oil. When aggregated, the data reported by these sectors approximately represent the consumption of petroleum products in the United States. Data presented in the PSM are divided into two sections: Summary Statistics and Detailed Statistics.

  11. COSMIC monthly progress report

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Activities of the Computer Software Management and Information Center (COSMIC) are summarized for the month of August, 1993. Tables showing the current inventory of programs available from COSMIC are presented and program processing and evaluation activities are discussed. Ten articles were prepared for publication in the NASA Tech Brief Journal. These articles (included in this report) describe the following software items: (1) MOM3D - A Method of Moments Code for Electromagnetic Scattering (UNIX Version); (2) EM-Animate - Computer Program for Displaying and Animating the Steady-State Time-Harmonic Electromagnetic Near Field and Surface-Current Solutions; (3) MOM3D - A Method of Moments Code for Electromagnetic Scattering (IBM PC Version); (4) M414 - MIL-STD-414 Variable Sampling Procedures Computer Program; (5) MEDOF - Minimum Euclidean Distance Optimal Filter; (6) CLIPS 6.0 - C Language Integrated Production System, Version 6.0 (Macintosh Version); (7) CLIPS 6.0 - C Language Integrated Production System, Version 6.0 (IBM PC Version); (8) CLIPS 6.0 - C Language Integrated Production System, Version 6.0 (UNIX Version); (9) CLIPS 6.0 - C Language Integrated Production System, Version 6.0 (DEC VAX VMS Version); and (10) TFSSRA - Thick Frequency Selective Surface with Rectangular Apertures. Activities in the areas of marketing, customer service, benefits identification, maintenance and support, and dissemination are also described along with a budget summary.

  12. COSMIC monthly progress report

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Activities of the Computer Software Management and Information Center (COSMIC) are summarized for the month of May 1994. Tables showing the current inventory of programs available from COSMIC are presented and program processing and evaluation activities are summarized. Nine articles were prepared for publication in the NASA Tech Brief Journal. These articles (included in this report) describe the following software items: (1) WFI - Windowing System for Test and Simulation; (2) HZETRN - A Free Space Radiation Transport and Shielding Program; (3) COMGEN-BEM - Composite Model Generation-Boundary Element Method; (4) IDDS - Interactive Data Display System; (5) CET93/PC - Chemical Equilibrium with Transport Properties, 1993; (6) SDVIC - Sub-pixel Digital Video Image Correlation; (7) TRASYS - Thermal Radiation Analyzer System (HP9000 Series 700/800 Version without NASADIG); (8) NASADIG - NASA Device Independent Graphics Library, Version 6.0 (VAX VMS Version); and (9) NASADIG - NASA Device Independent Graphics Library, Version 6.0 (UNIX Version). Activities in the areas of marketing, customer service, benefits identification, maintenance and support, and dissemination are also described along with a budget summary.

  13. The M w6.7 12 October 2013 western Hellenic Arc main shock and its aftershock sequence: implications for the slab properties

    NASA Astrophysics Data System (ADS)

    Papadimitriou, Eleftheria; Karakostas, Vassilis; Mesimeri, Maria; Vallianatos, Filippos

    2016-01-01

    The 12 October 2013 M w6.7 earthquake offshore Crete Island is one of the few strong earthquakes to have occurred in the last few decades in the southwestern part of the Hellenic subduction zone (HSZ), providing the opportunity to evaluate characteristics of the descending slab. The HSZ has experienced several strong (M ≥ 7.0) earthquakes in historical times with the largest one being the 365 AD, M w = 8.4 earthquake, the largest known ever occurred in the Mediterranean region. The 2013 main shock occurred in close proximity with the 365 event, on an interplate thrust fault at a depth of 26 km, onto the coupled part of the overriding and descending plates. GCMT solution shows a slightly oblique (rake = 130°) thrust faulting with downdip compression on a nearly horizontal (dip = 3°) northeast-dipping fault plane with strike (340°) parallel to the subduction front, with the compression axis being oriented in the direction of plate convergence. The subduction interface can be more clearly resolved with the integration of aftershock locations and CMT solution. For this scope, the aftershocks were relocated after obtaining a v p/v s ratio equal to 1.76, a one-dimensional velocity model and time delays that approximate the velocity structure of the study area, and the employment of double-difference technique for both phase pick data and cross-correlation differential times. The first-day relocated seismicity, alike aftershocks in the first 2 months, shows activation of an area at the upper part of the descending slab, with most activity being concentrated between 13 and 27 km, where the main shock is also encompassed. Aftershocks are rare near to the main shock, implying homogeneous slip on a large patch of the rupture plane. Based on the aftershock distribution, the size of the activated area estimated is about 24 km long and 17 km wide. Coulomb stress changes resolved for transpressive motion reveal negligible off-fault aftershock triggering, evidencing a

  14. The Daidzein Metabolite, 6,7,4'-Trihydroxyisoflavone, Is a Novel Inhibitor of PKCα in Suppressing Solar UV-Induced Matrix Metalloproteinase 1

    PubMed Central

    Lim, Tae-Gyu; Kim, Jong-Eun; Lee, Sung-Young; Park, Jun Seong; Yeom, Myung Hun; Chen, Hanyong; Bode, Ann M.; Dong, Zigang; Lee, Ki Won

    2014-01-01

    Soy isoflavone is an attractive source of functional cosmetic materials with anti-wrinkle, whitening and skin hydration effects. After consumption, the majority of soy isoflavones are converted to their metabolites in the human gastrointestinal tract. To understand the physiological impact of soy isoflavone on the human body, it is necessary to evaluate and address the biological function of its metabolites. In this study, we investigated the effect of 6,7,4'-trihydroxyisoflavone (6,7,4'-THIF), a major metabolite of daidzein, against solar UV (sUV)-induced matrix metalloproteinases (MMPs) in normal human dermal fibroblasts. MMPs play a critical role in the degradation of collagen in skin, thereby accelerating the aging process of skin. The mitogen-activated protein/extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MKK)3/6/p38 and MKK4/c-Jun N-terminal kinases (JNK) signaling pathways are known to modulate MMP-1 function, and their activation by sUV was significantly reduced by 6,7,4'-THIF pretreatment. Our results also indicated that the enzyme activity of protein kinase C (PKC)α, an upstream regulator of MKKs signaling, is suppressed by 6,7,4'-THIF using the in vitro kinase assay. Furthermore, the direct interaction between 6,7,4'-THIF and endogenous PKCα was confirmed using the pull-down assay. Not only sUV-induced MMP-1 expression, but also sUV-induced signaling pathway activation were decreased in PKCα knockdown cells. Overall, we elucidated the inhibitory effect of 6,7,4'-THIF on sUV-induced MMPs and suggest PKCα as its direct molecular target. PMID:25415304

  15. High electrical conductivity in Ni₃(2,3,6,7,10,11-hexaiminotriphenylene)₂, a semiconducting metal-organic graphene analogue.

    PubMed

    Sheberla, Dennis; Sun, Lei; Blood-Forsythe, Martin A; Er, Süleyman; Wade, Casey R; Brozek, Carl K; Aspuru-Guzik, Alán; Dincă, Mircea

    2014-06-25

    Reaction of 2,3,6,7,10,11-hexaaminotriphenylene with Ni(2+) in aqueous NH3 solution under aerobic conditions produces Ni3(HITP)2 (HITP = 2,3,6,7,10,11-hexaiminotriphenylene), a new two-dimensional metal-organic framework (MOF). The new material can be isolated as a highly conductive black powder or dark blue-violet films. Two-probe and van der Pauw electrical measurements reveal bulk (pellet) and surface (film) conductivity values of 2 and 40 S·cm(-1), respectively, both records for MOFs and among the best for any coordination polymer. PMID:24750124

  16. Electric power monthly, June 1988

    SciTech Connect

    Not Available

    1988-09-15

    Total net generation by electric utilities in the United States for the month of June 1988 was 232,183 gigawatthours, 3 percent higher than the amount reported a year ago. Although temperatures (measured by cooling degree days) for June 1988 were 9 percent warmer than normal, they were 3 percent cooler than for June 1987. A large portion of that higher demand for electricity was met by nuclear-powered generation. Net generation from nuclear power during June 1988 (44,079 gigawatthours) was only 1 percent below the record set in January of this year, and 21 percent above that reported in June 1987 (36,560 gigawatthours). The only energy source other than nuclear that reported higher levels of net generation during June 1988 was coal, up 2 percent over the same period last year. Warmer-than-normal temperatures did, however, have an affect on various parts of the country. For example, on Wednesday, June 22, 1988, unseasonably high temperatures forced the Pennsylvania, New Jersey, and Maryland Interconnection (PJM) into a system-wide 5-percent voltage reduction for 2 hours. Contributing to that reduction in voltage was the shutdown of the Three Mile Island, Unit 1, for refueling and the closing of the Peach Bottom Units 2 and 3 by the Nuclear Regulatory Commission. Three Mile Island, Unit 1, normally provides the PJM system with about 800 megawatts while the two Peach Bottom units, combined, provide approximately 2100 megawatts. 10 refs., 1 fig., 27 tabs.

  17. Monthly energy review, August 1997

    SciTech Connect

    1997-08-01

    The Monthly Energy Review for the month of August 1997, presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of U.S. production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors.

  18. Detection of Mixed-Phase Clouds over the Arctic Using MODIS 6.7-12 micron Data

    NASA Astrophysics Data System (ADS)

    Spangenberg, D. A.; Minnis, P.; Shupe, M. D.; Poellot, M. R.; Wang, Z.

    2005-12-01

    Over the Arctic, clouds containing both ice crystals and supercooled liquid droplets are a common occurrence and need to be taken into account in determining cloud microphysical properties. Presently, these mixed-phase (MIXP) clouds are detected fairly well by ground-based techniques, however, no information on their spatial extent is available. Satellite data has excellent spatial coverage and provides a means to extend the information on cloud phase away from the ground sites. To accomplish this goal, an Arctic cloud phase model is developed to detect MIXP clouds using Moderate Resolution Imaging Spectroradiometer (MODIS) data taken onboard the Terra and Aqua satellites. The model utilizes three water vapor and two cloud-top temperature channels in the 6.7-12 μm wavelength range. To develop the model, a wide range of cloud systems were sampled where the brightness temperature (BT) data from MODIS was compared to surface-based phase retrievals at the Atmospheric Radiation Measurement (ARM) North Slope of Alaska (NSA) Barrow site. Cloud phase can be linked to specific sets of thermal and moisture structures existing between the upper part of the cloud and the upper troposphere. These structures are, in turn, reflected in the MODIS BT data. Results from the ARM MODIS cloud-phase model (AMCPM) are compared to surface-based retrievals over the ARM-NSA Barrow site and to in-situ data from the Citation aircraft which flew during the ARM Mixed-Phase Arctic Cloud Experiment. Since the AMCPM only uses channels in the infrared part of the spectrum, it can be applied to both daytime and nighttime scenes with no discontinuities in the output phase. Preliminary results are encouraging with an agreement between MODIS and the surface-based retrievals of over 75 %. The MIXP clouds considered here are those having generally between 10 and 90 % liquid water out of the total water content. The model should be applied to high-latitude regions only and even there, it is unclear how

  19. 76 FR 24065 - Board Workshop: June 6-7, 2011-Arlington, Virginia; the U.S. Nuclear Waste Technical Review Board...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... REVIEW BOARD Board Workshop: June 6-7, 2011--Arlington, Virginia; the U.S. Nuclear Waste Technical Review... Waste Technical Review Board will hold a workshop on Monday, June 6, and Tuesday, June 7, 2011, in... high-level radioactive waste and to review the technical validity of DOE activities related...

  20. The Influence of Inclusion on the Academic Performance of General Education Students on the New Jersey Assessment of Skills and Knowledge in Grades 6, 7, and 8

    ERIC Educational Resources Information Center

    Robinson, Christie M.

    2012-01-01

    This study examined the impact of student variables (student socioeconomic status, race, attendance, and gender) and the school variable of placement in an inclusion setting on the academic achievement of general education students in grades 6, 7, and 8 in an urban school district. Academic achievement was defined as a general education student's…

  1. Family and Consumer Sciences Technology-Life-Careers Core Curriculum. A Curriculum Guide. A Family and Consumer Sciences Education Course of Study for Grades 6-7.

    ERIC Educational Resources Information Center

    Utah State Office of Education, Salt Lake City.

    This curriculum, part of a coordinated exploratory vocational core program, is an activity-oriented instructional course that enables students in grades 6-7 to explore careers and skills related to consumer and occupational roles. The curriculum consists of five units: (1) independent living skills; (2) families; (3) child care; (4) textiles…

  2. Frontolimbic Neural Circuitry at 6 Months Predicts Individual Differences in Joint Attention at 9 Months

    ERIC Educational Resources Information Center

    Elison, Jed T.; Wolff, Jason J.; Heimer, Debra C.; Paterson, Sarah J.; Gu, Hongbin; Hazlett, Heather C.; Styner, Martin; Gerig, Guido; Piven, Joseph

    2013-01-01

    Elucidating the neural basis of joint attention in infancy promises to yield important insights into the development of language and social cognition, and directly informs developmental models of autism. We describe a new method for evaluating responding to joint attention performance in infancy that highlights the 9- to 10-month period as a time…

  3. New detections of HC5N towards hot cores associated with 6.7 GHz methanol masers

    NASA Astrophysics Data System (ADS)

    Green, C.-E.; Green, J. A.; Burton, M. G.; Horiuchi, S.; Tothill, N. F. H.; Walsh, A. J.; Purcell, C. R.; Lovell, J. E. J.; Millar, T. J.

    2014-09-01

    We present new detections of cyanodiacetylene (HC5N) towards hot molecular cores, observed with the Tidbinbilla 34 m radio telescope (DSS-34). In a sample of 79 hot molecular cores, HC5N was detected towards 35. These results are counter to the expectation that long chain cyanopolyynes, such as HC5N, are not typically found in hot molecular cores, unlike their shorter chain counterpart HC3N. However, it is consistent with recent models which suggest HC5N may exist for a limited period during the evolution of hot molecular cores.

  4. Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months.

    PubMed

    Elison, Jed T; Wolff, Jason J; Heimer, Debra C; Paterson, Sarah J; Gu, Hongbin; Hazlett, Heather C; Styner, Martin; Gerig, Guido; Piven, Joseph

    2013-03-01

    Elucidating the neural basis of joint attention in infancy promises to yield important insights into the development of language and social cognition, and directly informs developmental models of autism. We describe a new method for evaluating responding to joint attention performance in infancy that highlights the 9- to 10-month period as a time interval of maximal individual differences. We then demonstrate that fractional anisotropy in the right uncinate fasciculus, a white matter fiber bundle connecting the amygdala to the ventral-medial prefrontal cortex and anterior temporal pole, measured in 6-month-olds predicts individual differences in responding to joint attention at 9 months of age. The white matter microstructure of the right uncinate was not related to receptive language ability at 9 months. These findings suggest that the development of core nonverbal social communication skills in infancy is largely supported by preceding developments within right lateralized frontotemporal brain systems. PMID:23432829

  5. Frontolimbic Neural Circuitry at 6 Months Predicts Individual Differences in Joint Attention at 9 Months

    PubMed Central

    Elison, Jed T.; Wolff, Jason J.; Heimer, Debra C.; Paterson, Sarah J.; Gu, Hongbin; Hazlett, Heather C.; Styner, Martin; Gerig, Guido; Piven, Joseph

    2012-01-01

    Elucidating the neural basis of joint attention in infancy promises to yield important insights into the development of language and social cognition, and directly informs developmental models of autism. We describe a new method for evaluating responding to joint attention performance in infancy that highlights the 9 to 10 month period as a time interval of maximal individual differences. We then demonstrate that fractional anisotropy in the right uncinate fasciculus, a white matter fiber bundle connecting the amygdala to the ventral-medial prefrontal cortex and anterior temporal pole, measured in 6 month-olds predicts individual differences in responding to joint attention at 9 months of age. The white matter microstructure of the right uncinate was not related to receptive language ability at 9 months. These findings suggest that the development of core nonverbal social communication skills in infancy is largely supported by preceding developments within right lateralized frontotemporal brain systems. PMID:23432829

  6. 20 CFR 404.325 - The termination month.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false The termination month. 404.325 Section 404.325 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY.... In April 2003, 4 months after your reentitlement period ends, you become employed at work that...

  7. 20 CFR 404.325 - The termination month.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false The termination month. 404.325 Section 404.325 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY.... In April 2003, 4 months after your reentitlement period ends, you become employed at work that...

  8. Building a Culture of Literacy Month-by-Month

    ERIC Educational Resources Information Center

    Davis, Hilarie

    2008-01-01

    This book will help create a culture of literacy at schools, from the classroom, to the lunchroom, to the hallways-a culture that encompasses students, teachers, administrators, families, and communities. This comprehensive and practical book includes: (1) Month-by-month plans for the entire school year; (2) How to build a faculty vision of…

  9. Natural gas monthly, August 1995

    SciTech Connect

    1995-08-24

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. This month`s feature article is on US Natural Gas Imports and Exports 1994.

  10. Natural gas monthly, July 1997

    SciTech Connect

    1997-07-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. The feature article this month is entitled ``Intricate puzzle of oil and gas reserves growth.`` A special report is included on revisions to monthly natural gas data. 6 figs., 24 tabs.

  11. Natural gas monthly: April 1996

    SciTech Connect

    1996-04-01

    The Natural Gas Monthly highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. This month`s feature article focuses on preliminary highlights from the 1995 natural gas industry. 7 figs., 25 tabs.

  12. Natural Gas Monthly, October 1993

    SciTech Connect

    Not Available

    1993-11-10

    The (NGM) Natural Gas Monthly highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. This month`s feature articles are: US Production of Natural Gas from Tight Reservoirs: and Expanding Rule of Underground Storage.

  13. Monthly energy review, January 1998

    SciTech Connect

    1998-01-01

    This report presents an overview of recent monthly energy statistics. Major activities covered include production, consumption, trade, stocks, and prices for fossil fuels, electricity, and nuclear energy.

  14. High Electrical Conductivity in Ni3(2,3,6,7,10,11-hexaiminotriphenylene)2, a Semiconducting Metal-Organic Graphene Analogue

    SciTech Connect

    Sheberla, Dennis; Sun, Lei; Blood-Forsythe, Martin A.; Er, Süleyman; Wade, Casey R.; Brozek, Carl K.; Aspuru-Guzik, Alán; Dinc,; #259; Mircea,

    2014-09-22

    Reaction of 2,3,6,7,10,11-hexaaminotriphenylene with Ni2+ in aqueous NH3 solution under aerobic conditions produces Ni3(HITP)2 (HITP = 2,3,6,7,10,11-hexaiminotriphenylene), a new two-dimensional metal–organic framework (MOF). The new material can be isolated as a highly conductive black powder or dark blue-violet films. Two-probe and van der Pauw electrical measurements reveal bulk (pellet) and surface (film) conductivity values of 2 and 40 S·cm–1, respectively, both records for MOFs and among the best for any coordination polymer.

  15. Design and flight performance evaluation of the Mariners 6, 7, and 9 short-circuit current, open-circuit voltage transducers

    NASA Technical Reports Server (NTRS)

    Patterson, R. E.

    1973-01-01

    The purpose of the short-circuit voltage transducer is to provide engineering data to aid the evaluation of array performance during flight. The design, fabrication, calibration, and in-flight performance of the transducers onboard the Mariner 6, 7 and 9 spacecrafts are described. No significant differences were observed in the in-flight electrical performance of the three transducers. The transducers did experience significant losses due to coverslides or adhesive darkening, increased surface reflection, or spectral shifts within coverslide assembly. Mariner 6, 7 and 9 transducers showed non-cell current degradations of 3-1/2%, 3%, and 4%, respectively at Mars encounter and 6%, 3%, and 4-12%, respectively at end of mission. Mariner 9 solar Array Test 2 showed 3-12% current degradation while the transducer showed 4-12% degradation.

  16. Vertical displacement of the mid-tropospheric water vapor boundary in the tropics derived from the VISSR Atmospheric Sounder (VAS) 6.7-micron channel

    NASA Technical Reports Server (NTRS)

    Stout, J.; Steranka, J.; Petersen, R. A.

    1984-01-01

    A technique for locating areas of upward or downward motion of the upper boundary of the midtropospheric water-vapor envelope over tropical oceans on the basis of GOES Visible/IR Spin-Scan Radiometer (VISSR) Atmospheric Sounder (VAS) 6.7-micron brightness temperatures is developed and demonstrated. The technique employs an analogy to the method developed by Schoeberl and Krueger (1983) for the bottom of the ozone layer and depends on the relationship investigated by Chesters and Uccellini (1982) between 6.7-micron brightness temperature and the pressure of the water-vapor upper boundary. The results of analysis of VAS data for the North Atlantic (20-40 deg N and 35-75 deg W) on September 5-7, 1982, are presented in maps which are shown to be physically consistent and in agreement with conventional upper-air measurements. Refinement of the method to account for horizontal advection and diffusion is suggested.

  17. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. [Tetrahydropyrene and hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H[sub 2] hydrogenation reaction network.

  18. Monthly energy review: April 1996

    SciTech Connect

    1996-04-01

    This monthly report presents an overview of energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. A section is also included on international energy. The feature paper which is included each month is entitled ``Energy equipment choices: Fuel costs and other determinants.`` 37 figs., 59 tabs.

  19. Natural gas monthly, December 1998

    SciTech Connect

    1998-12-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. 6 figs., 28 tabs.

  20. Monthly energy review, November 1998

    SciTech Connect

    1998-11-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. 37 figs., 61 tabs.

  1. Monthly energy review, May 1999

    SciTech Connect

    1999-05-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. 37 figs., 61 tabs.

  2. Monthly energy review, July 1998

    SciTech Connect

    1998-07-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. 37 figs. 73 tabs.

  3. Monthly Energy Review, February 1996

    SciTech Connect

    1996-02-26

    This monthly publication presents an overview of EIA`s recent monthly energy statistics, covering the major activities of U.S. production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. Two brief descriptions (`energy plugs`) on two EIA publications are presented at the start.

  4. Monthly energy review, November 1997

    SciTech Connect

    1997-11-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. 37 figs., 91 tabs.

  5. Monthly energy review, October 1998

    SciTech Connect

    1998-10-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. 37 figs., 61 tabs.

  6. Monthly energy review, March 1999

    SciTech Connect

    1999-03-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. 37 figs., 74 tabs.

  7. Monthly energy review, November 1996

    SciTech Connect

    1996-11-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. 75 tabs.

  8. Haida Months of the Year.

    ERIC Educational Resources Information Center

    Cogo, Robert

    Students are introduced to Haida vocabulary in this booklet which briefly describes the seasons and traditional seasonal activities of Southeastern Alaska Natives. The first section lists the months in English and Haida; e.g., January is "Taan Kungaay," or "Bear Hunting Month." The second section contains seasonal names in Haida and English as…

  9. Monthly energy review, June 1998

    SciTech Connect

    1998-06-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. 36 figs., 61 tabs.

  10. Monthly energy review, January 1999

    SciTech Connect

    1999-01-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. 37 figs., 61 tabs.

  11. Monthly energy review, February 1999

    SciTech Connect

    1999-02-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. 37 figs., 73 tabs.

  12. Natural gas monthly, February 1999

    SciTech Connect

    1999-02-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. 6 figs., 28 tabs.

  13. Natural gas monthly, January 1999

    SciTech Connect

    1999-02-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. 6 figs., 28 tabs.

  14. Natural gas monthly, November 1998

    SciTech Connect

    1998-11-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. 6 figs., 27 tabs.

  15. The Association between Birth Weight and Gestational Age and Asthma in 6-7- and 13-14-Year-Old Children

    PubMed Central

    Raheleh, Zamani; Ahmad, Alikhani; Abtin, Heydarzadeh; Roghaye, Zare; Sara, Hashemain; Siavash, Rahimi

    2016-01-01

    Background. Previous studies that assessed the role of birth weight and gestational age in the risk of asthma have been conflicting. Objectives. To examine the association between birth weight and gestational age and symptoms of asthma. Patients and Methods. Subjects were 6656 school children of ages 6-7 and 13-14 years from urban districts of Mazandaran, Iran. ISAAC questionnaires were used. Results. There was an increased risk of “wheeze ever” in both age groups with birth weight under 2.5 kg and in all subgroups of low birth weight (LBW). Birth weight more than 3.5 kg was associated with lower risk of “severe asthma” in age group 6-7 years. With respect to gestational age, higher risks of “wheeze ever,” “asthma ever,” and “night cough in the past 12 months” were found in age group 13-14 years born before 37 weeks and the risk of “severe asthma” was higher in younger group (6-7 years). A lower risk of "asthma ever" was also found in 6-7-year-old children and 13-14-year-old girls who were born after 40 weeks. Conclusions. This study showed that there is a direct relation between “wheeze ever” and LBW and an inverse relation between risk of “severe asthma” and birth weight more than 3.5 kg. PMID:27379196

  16. Cytotoxic, Antiproliferative and Pro-Apoptotic Effects of 5-Hydroxyl-6,7,3′,4′,5′-Pentamethoxyflavone Isolated from Lantana ukambensis

    PubMed Central

    Sawadogo, Wamtinga Richard; Cerella, Claudia; Al-Mourabit, Ali; Moriou, Céline; Teiten, Marie-Hélène; Guissou, Innocent Pierre; Dicato, Mario; Diederich, Marc

    2015-01-01

    Lantana ukambensis (Vatke) Verdc. is an African food and medicinal plant. Its red fruits are eaten and highly appreciated by the rural population. This plant was extensively used in African folk medicinal traditions to treat chronic wounds but also as anti-leishmanial or cytotoxic remedies, especially in Burkina Faso, Tanzania, Kenya, or Ethiopia. This study investigates the in vitro bioactivity of polymethoxyflavones extracted from a L. ukambensis as anti-proliferative and pro-apoptotic agents. We isolated two known polymethoxyflavones, 5,6,7,3′,4′,5′-hexamethoxyflavone (1) and 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) from the whole plant of L. ukambensis. Their chemical structures were determined by spectroscopic analysis and comparison with published data. These molecules were tested for the anti-proliferative, cytotoxic and pro-apoptotic effects on human cancer cells. Among them, 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) was selectively cytotoxic against monocytic lymphoma (U937), acute T cell leukemia (Jurkat), and chronic myelogenous leukemia (K562) cell lines, but not against peripheral blood mononuclear cells (PBMCs) from healthy donors, at all tested concentrations. Moreover, this compound exhibited significant anti-proliferative and pro-apoptotic effects against U937 acute myelogenous leukemia cells. This study highlights the anti-proliferative and pro-apoptotic effects of 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) and provides a scientific basis of traditional use of L. ukambensis. PMID:26690473

  17. Tandem Action of the O2- and FADH2-Dependent Halogenases KtzQ and KtzR Produce 6,7-Dichlorotryptophan for Kutzneride Assembly

    PubMed Central

    Heemstra, John R.; Walsh, Christopher T.

    2009-01-01

    Kutznerides are actinomycete-derived antifungal nonribosomal hexadepsipeptides which are assembled from five unsual nonproteinogenic amino acids and one hydroxy acid. Conserved in all structurally characterized kutznerides is a dichlorinated tricyclic hexahydropyrroloindole postulated to be derived from 6,7-dichlorotryptophan. In this communication, we identify KtzQ and KtzR as tandem acting FADH2-dependent halogenases that work sequentially on free l-tryptophan to generate 6,7-dichloro-l-tryptophan. Kinetic characterization of these two enzymes has shown that KtzQ (along with the flavin reductase KtzS) acts first to chlorinate at the 7-position of l-tryptophan. KtzR, with a ~120 fold preference for 7-chloro-l-tryptophan over l-tryptophan, then installs the second chlorine at the 6-position of 7-chloro-l-tryptophan to generate 6,7-dichloro-l-tryptophan. These findings provide further insights into the enzymatic logic of carbon-chloride bond formation during the biosynthesis of halogenated secondary metabolites. PMID:18828589

  18. Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly.

    PubMed

    Heemstra, John R; Walsh, Christopher T

    2008-10-29

    Kutznerides are actinomycete-derived antifungal nonribosomal hexadepsipeptides which are assembled from five unsual nonproteinogenic amino acids and one hydroxy acid. Conserved in all structurally characterized kutznerides is a dichlorinated tricyclic hexahydropyrroloindole postulated to be derived from 6,7-dichlorotryptophan. In this Communication, we identify KtzQ and KtzR as tandem acting FADH2-dependent halogenases that work sequentially on free L-tryptophan to generate 6,7-dichloro-L-tryptophan. Kinetic characterization of these two enzymes has shown that KtzQ (along with the flavin reductase KtzS) acts first to chlorinate at the 7-position of L-tryptophan. KtzR, with a 120 fold preference for 7-chloro-L-tryptophan over L-tryptophan, then installs the second chlorine at the 6-position of 7-chloro-L-tryptophan to generate 6,7-dichloro-L-tryptophan. These findings provide further insights into the enzymatic logic of carbon-chloride bond formation during the biosynthesis of halogenated secondary metabolites. PMID:18828589

  19. Localization of vacancies and mobility of lithium ions in Li{sub 2}ZrO{sub 3} as obtained by {sup 6,7}Li NMR

    SciTech Connect

    Baklanova, Ya. V.; Arapova, I. Yu.; Buzlukov, A.L.; Gerashenko, A.P.; Verkhovskii, S.V.; Mikhalev, K.N.; Denisova, T.A.; Shein, I.R.; Maksimova, L.G.

    2013-12-15

    The {sup 6,7}Li NMR spectra and the {sup 7}Li spin–lattice relaxation rate were measured on polycrystalline samples of Li{sub 2}ZrO{sub 3}, synthesized at 1050 K and 1300 K. The {sup 7}Li NMR lines were attributed to corresponding structural positions of lithium Li1 and Li2 by comparing the EFG components with those obtained in the first-principles calculations of the charge density in Li{sub 2}ZrO{sub 3}. For both samples the line width of the central {sup 7}Li transition and the spin–lattice relaxation time decrease abruptly at the temperature increasing above ∼500 K, whereas the EFG parameters are averaged (〈ν{sub Q}〉=42 (5) kHz) owing to thermally activated diffusion of lithium ions. - Graphical abstract: Path of lithium ion hopping in lithium zirconate Li{sub 2}ZrO{sub 3}. - Highlights: • Polycrystalline samples Li{sub 2}ZrO{sub 3} with monoclinic crystal structure synthesized at different temperatures were investigated by {sup 6,7}Li NMR spectroscopy. • Two {sup 6,7}Li NMR lines were attributed to the specific structural positions Li1 and Li2. • The distribution of vacancies was clarified for both lithium sites. • The activation energy and pathways of lithium diffusion in Li{sub 2}ZrO{sub 3} were defined.

  20. Monthly Record of Current Educational Publications. Bulletin, 1921, No. 1

    ERIC Educational Resources Information Center

    Bureau of Education, Department of the Interior, 1921

    1921-01-01

    This bulletin contains a list of general survey in bibliographic form of current educational literature, domestic and foreign, received during the monthly period preceding the date of publication of each issue. Books, pamphlets, and periodicals mentioned may ordinarily be obtained from their respective publishers, either directly or through a…

  1. Monthly Record of Current Educational Publications. Bulletin, 1919, No. 11

    ERIC Educational Resources Information Center

    Bureau of Education, Department of the Interior, 1919

    1919-01-01

    This bulletin comprises a general survey in bibliographic form of current educational literature, domestic and foreign, received during the monthly period preceding the date of its publication. Books, pamphlets, and periodicals mentioned in this bulletin may ordinarily be obtained from their respective publishers, either directly or through a…

  2. Monthly Record of Current Educational Publications. Bulletin, 1920, No. 38

    ERIC Educational Resources Information Center

    Bureau of Education, Department of the Interior, 1920

    1920-01-01

    The record comprises a general survey in bibliographic form of current educational literature, domestic and foreign, received during the monthly period preceding the date of publication of each issue. Books, pamphlets, and periodicals mentioned may ordinarily be obtained from their respective publishers, either directly or through a dealer, or, in…

  3. Monthly Record of Current Educational Publications. Bulletin, 1919, No. 83

    ERIC Educational Resources Information Center

    Bureau of Education, Department of the Interior, 1919

    1919-01-01

    This bulletin comprises a general survey in bibliographic form of current educational literature, domestic and foreign, received during the monthly period preceding the date of its publication. Books, pamphlets, and periodicals mentioned may ordinarily be obtained from their respective publishers, either directly or through a dealer, or, in the…

  4. Monthly Record of Current Educational Publications. Bulletin, 1921, No. 3

    ERIC Educational Resources Information Center

    Bureau of Education, Department of the Interior, 1921

    1921-01-01

    This bulletin contains a list of general survey in bibliographic form of current educational literature, domestic and foreign, received during the monthly period preceding the date of publication of each issue. Books, pamphlets, and periodicals mentioned may ordinarily be obtained from their respective publishers, either directly or through a…

  5. Monthly Record of Current Educational Publications. Bulletin, 1919, No. 23

    ERIC Educational Resources Information Center

    Bureau of Education, Department of the Interior, 1919

    1919-01-01

    This bulletin comprises a general survey in bibliographic form of current educational literature, domestic and foreign, received during the monthly period preceding the date of its publication. Books, pamphlets, and periodicals mentioned may ordinarily be obtained from their respective publishers, either directly or through a dealer, or, in the…

  6. Monthly Record of Current Educational Publications. Bulletin, 1920, No. 32

    ERIC Educational Resources Information Center

    Bureau of Education, Department of the Interior, 1920

    1920-01-01

    This bulletin comprises a general survey in bibliographic form of current educational literature, domestic and foreign, received during the monthly period preceding the date of publication of each issue. Books, pamphlets, and periodicals mentioned may ordinarily be obtained from their respective publishers, either directly or through a dealer, or,…

  7. Monthly Record of Current Educational Publications. Bulletin, 1919, No. 75

    ERIC Educational Resources Information Center

    Bureau of Education, Department of the Interior, 1919

    1919-01-01

    This bulletin comprises a general survey in bibliographic form of current educational literature, domestic and foreign, received during the monthly period preceding the date of its publication. Books, pamphlets, and periodicals mentioned in this bulletin may ordinarily be obtained from their respective publishers, either directly or through a…

  8. Monthly Record of Current Educational Publications. Bulletin, 1920, No. 15

    ERIC Educational Resources Information Center

    Bureau of Education, Department of the Interior, 1920

    1920-01-01

    The record comprises a general survey in bibliographic form of current educational literature, domestic and foreign, received during the monthly period preceding the date of publication of each issue. Books, pamphlets, and periodicals mentioned may ordinarily be obtained from their respective publishers, either directly or through a dealer, or, in…

  9. 17 CFR 1.33 - Monthly and confirmation statements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the account balance since the prior statement period, but in any event not less frequently than once... during the monthly reporting period, identified by underlying futures contract or underlying physical... futures contract or underlying physical, strike price, transaction date, and expiration date; (iii)...

  10. 29 CFR 531.56 - “More than $20 a month in tips.”

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... monthly period beginning on the same day of the calendar month may be used. (c) Individual tip receipts... of employment, see § 531.58. (d) Significance of minimum monthly tip receipts. More than $20 a month... situations an employee is employed in a dual job, as for example, where a maintenance man in a hotel...

  11. Ensemble-based analysis of Front Range severe convection on 6-7 June 2012: Forecast uncertainty and communication of weather information to Front Range decision-makers

    NASA Astrophysics Data System (ADS)

    Vincente, Vanessa

    The variation of topography in Colorado not only adds to the beauty of its landscape, but also tests our ability to predict warm season severe convection. Deficient radar coverage and limited observations make quantitative precipitation forecasting quite a challenge. Past studies have suggested that greater forecast skill of mesoscale convection initiation and precipitation characteristics are achievable considering an ensemble with explicitly predicted convection compared to one that has parameterized convection. The range of uncertainty and probabilities in these forecasts can help forecasters in their precipitation predictions and communication of weather information to emergency managers (EMs). EMs serve an integral role in informing and protecting communities in anticipation of hazardous weather. An example of such an event occurred on the evening of 6 June 2012, where areas to the lee of the Rocky Mountain Front Range were impacted by flash-flood-producing severe convection that included heavy rain and copious amounts of hail. Despite the discrepancy in the timing, location and evolution of convection, the convection-allowing ensemble forecasts generally outperformed those of the convection-parameterized ensemble in representing the mesoscale processes responsible for the 6-7 June severe convective event. Key features sufficiently reproduced by several of the convection-allowing ensemble members resembled the observations: 1) general location of a convergence boundary east of Denver, 2) convective initiation along the boundary, 3) general location of a weak cold front near the Wyoming/Nebraska border, and 4) cold pools and moist upslope characteristics that contributed to the backbuilding of convection. Members from the convection-parameterized ensemble that failed to reproduce these results displaced the convergence boundary, produced a cold front that moved southeast too quickly, and used the cold front for convective initiation. The convection

  12. Basque meteorology monthly meteorological bulletins

    NASA Astrophysics Data System (ADS)

    Hernandez, R.; Gaztelumendi, S.; Otxoa de Alda, K.; Egaña, J.; Gelpi, I. R.

    2009-09-01

    In this work we present the monthly meteorological bulletins of the Basque Meteorology Agency (EUSKALMET). This bulletin includes a monthly meteorological summary for Basque Country Area, including some statistical data, graphs and maps for relevant variables, and descriptive test of meteorological situation, including monthly summary and a description for some relevant severe weather cases. An intensive use of Basque Country Automatic Weather Station (AWS) mesonet data is made in its elaboration. The Basque Meteorology Agency has among theirs functions to serve different requests that often include some type of statistical data, the elaboration of monthly bulletins and the meteorological annual bulletin, published by the Direction of Meteorology and Climatology - Department of Transports and Civil Works - Basque Government. For the monthly meteorological summary elaboration, use of data coming from the ten-minutes AWS network available in our territory is made. In this context, ten-minutes data are used for daily and monthly data statistics. Information is presented, for an easy interpretation, using different tabular format and graphics focused on air temperature and precipitation. The monitoring of this last meteorological element is completed with maps of monthly actual precipitation and its anomalies, expressed as the departure from normal precipitation and percent of normal precipitation.

  13. Unveiling the gas kinematics at 10 AU scales in high-mass star-forming regions. Milliarcsecond structure of 6.7 GHz methanol masers

    NASA Astrophysics Data System (ADS)

    Moscadelli, L.; Sanna, A.; Goddi, C.

    2011-12-01

    Context. High-mass stars play a prominent role in Galactic evolution, but their formation mechanism is still poorly understood. This lack of knowledge reflects the observational limitations of present instruments, whose angular resolution (at the typical distances of massive protostars) precludes probing circumstellar gas on scales of 1-100 AU, relevant for a detailed investigation of accretion structures and launch/collimation mechanims of outflows in high-mass star formation. Aims: This work presents a study of the milliarcsecond structure of the 6.7 GHz methanol masers at high-velocity resolution (0.09 km s-1) in four high-mass star-forming regions: G16.59-0.05, G23.01-0.41, IRAS 20126 + 4104, and AFGL 5142. Methods: We studied these sources by means of multi-epoch VLBI observations in the 22 GHz water and 6.7 GHz methanol masers, to determine the 3-D gas kinematics within a few thousand AU from the (proto)star. Our results demonstrate the ability of maser emission to trace kinematic structures close to the (proto)star, revealing the presence of fast wide-angle and/or collimated outflows (traced by the H2O masers), and of rotation and infall (indicated by the CH3OH masers). The present work exploits the 6.7 GHz maser data collected so far to investigate the milliarcsecond structure of this maser emission at high-velocity resolution. Results: Most of the detected 6.7 GHz maser features present an ordered (linear, or arc-like) distribution of maser spots on the plane of the sky, together with a regular variation in the spot LSR velocity (VLSR) with position. Typical values for the amplitude of the VLSR gradients (defined in terms of the derivative of the spot VLSR with position) are found to be 0.1-0.2 km s-1 mas-1. In each of the four target sources, the orientation and the amplitude of most of the feature VLSR gradients remain remarkably stable in time, on timescales of (at least) several years. We also find that the data are consistent with having the VLSR

  14. Natural gas monthly, June 1996

    SciTech Connect

    1996-06-24

    The natural gas monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. The feature article for this month is Natural Gas Industry Restructuring and EIA Data Collection.

  15. Natural gas monthly, November 1996

    SciTech Connect

    1996-11-01

    The report highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the Natural Gas Monthly features articles designed to assist readers in using and interpreting natural gas information. The feature article this month is ``US natural gas imports and exports-1995``. 6 figs., 24 tabs.

  16. Natural gas monthly, June 1994

    SciTech Connect

    Not Available

    1994-06-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. The feature article this month is the executive summary from Natural Gas 1994: Issues and Trends. 6 figs., 31 tabs.

  17. Natural gas monthly, May 1997

    SciTech Connect

    1997-05-01

    The Natural Gas Monthly highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. The feature article this month is ``Restructuring energy industries: Lessons from natural gas.`` 6 figs., 26 tabs.

  18. Natural gas monthly, December 1997

    SciTech Connect

    1997-12-01

    The Natural Gas Monthly highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. The article this month is entitled ``Recent Trends in Natural Gas Spot Prices.`` 6 figs., 27 tabs.

  19. Natural gas monthly, January 1994

    SciTech Connect

    Not Available

    1994-02-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. The featured article for this month is on US coalbed methane production.

  20. Monthly Energy Review, July 1992

    SciTech Connect

    1992-07-27

    The Monthly Energy Review is prepared by the Energy Information Administration. Topics discussed include: Energy Overview, Energy Consumption, Petroleum, Natural Gas, Oil and Gas Resource Development, Coal, Electricity, Nuclear Energy, Energy Prices, International Energy. (VC)

  1. Seven Months of the Sun

    NASA Video Gallery

    This multi-wavelength movie of the Sun covers seven months of activity (April 25 - Nov. 30, 2011), the majority of the SDO mission to date. The frames combine images taken at the same time in three...

  2. Monthly energy review, July 1997

    SciTech Connect

    1997-07-01

    This document presents an overview of recent monthly energy statistics. Activities covered include: U.S. production, consumption, trade, stock, and prices for petroleum, coal, natural gas, electricity, and nuclear energy.

  3. Monthly energy review, August 1996

    SciTech Connect

    1996-08-01

    This report presents an overview of recent monthly energy statistics. The statistics cover the major activities of U.S. production, consumption, trade, stocks, and prices for petroleum, coal, natural gas, electricity, and nuclear energy.

  4. Monthly energy review, August 1993

    SciTech Connect

    Not Available

    1993-08-26

    This publication presents information for the month of August, 1993 on the following: Energy overview; energy consumption; petroleum; natural gas; oil and gas resource development; coal; electricity; nuclear energy; energy prices, and international energy.

  5. Natural gas monthly, April 1995

    SciTech Connect

    1995-04-27

    The Natural Gas Monthly highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. 6 figs., 31 tabs.

  6. Natural Gas Monthly, March 1996

    SciTech Connect

    1996-03-25

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  7. Natural gas monthly: December 1993

    SciTech Connect

    Not Available

    1993-12-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. Articles are included which are designed to assist readers in using and interpreting natural gas information.

  8. Natural gas monthly, June 1993

    SciTech Connect

    Not Available

    1993-06-22

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  9. Natural gas monthly, November 1993

    SciTech Connect

    Not Available

    1993-11-29

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground state data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  10. Natural gas monthly, August 1994

    SciTech Connect

    Not Available

    1994-08-24

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  11. Natural gas monthly, June 1997

    SciTech Connect

    1997-06-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. 6 figs., 24 tabs.

  12. Natural gas monthly, July 1998

    SciTech Connect

    1998-07-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. 6 figs., 25 tabs.

  13. Natural gas monthly, April 1994

    SciTech Connect

    Not Available

    1994-04-26

    The National Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  14. Natural gas monthly, July 1993

    SciTech Connect

    Not Available

    1993-07-27

    The Natural Gas Monthly NGM highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  15. Monthly energy review, April 1999

    SciTech Connect

    1999-04-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. The MER is intended for use by Members of Congress, Federal and State agencies, energy analysts, and the general public.

  16. Monthly energy review, April 1998

    SciTech Connect

    1998-04-01

    This report presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of U.S. production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy data. A brief summary of the monthly and historical comparison data is provided in Section 1 of the report. A highlight section of the report provides an assessment of summer 1997 motor gasoline price increases.

  17. Natural gas monthly, June 1999

    SciTech Connect

    1999-06-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. 6 figs., 25 tabs.

  18. Monthly energy review, August 1998

    SciTech Connect

    1998-08-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. The MER is intended for use by Members of Congress, Federal and State agencies, energy analysts, and the general public. 37 figs., 73 tabs.

  19. Natural gas monthly, October 1995

    SciTech Connect

    1995-10-23

    The Natural Gas Monthly highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. A glossary of the terms used in this report is provided to assist readers in understanding the data presented in this publication. 6 figs., 30 tabs.

  20. Natural gas monthly, May 1999

    SciTech Connect

    1999-05-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time the NGM features articles designed to assist readers in using and interpreting natural gas information. 6 figs., 27 tabs.

  1. Twelve months of experience with Bioplastique.

    PubMed

    Mladick, R A

    1992-01-01

    Over a 12-month period, 40 patients were treated for various facial defects using a new, injectable microimplant material--Bioplastique. Areas treated included cheeks, chins, lips, nasolabial lines, nasoglabellar lines, infraoral lines, noses, and miscellaneous depressions. Patients were observed for overcorrection, inflammation, morbidity, allergic reaction, or other complications. Both patient and physician satisfaction were recorded. Use of Bioplastique was found to offer permanent results by means of a quick, simple procedure administered under local anesthesia without scarring. With proper training and a good "eye," subtle corrections are possible. The author anticipates wide application of Bioplastique for the treatment of numerous soft tissue deficiencies. PMID:1734634

  2. Effect of broadband-noise masking on the behavioral response of a harbor porpoise (Phocoena phocoena) to 1-s duration 6-7 kHz sonar up-sweeps.

    PubMed

    Kastelein, Ronald A; Steen, Nele; de Jong, Christ; Wensveen, Paul J; Verboom, Willem C

    2011-04-01

    Naval sonar systems produce signals which may affect the behavior of harbor porpoises, though their effect may be reduced by ambient noise. To show how natural ambient noise influences the effect of sonar sweeps on porpoises, a porpoise in a pool was exposed to 1-s duration up-sweeps, similar in frequency range (6-7 kHz) to those of existing naval sonar systems. The sweep signals had randomly generated sweep intervals of 3-7 s (duty cycle: 19%). Behavioral parameters during exposure to signals were compared to those during baseline periods. The sessions were conducted under five background noise conditions: the local normal ambient noise and four conditions mimicking the spectra for wind-generated noise at Sea States 2-8. In all conditions, the sweeps caused the porpoise to swim further away from the transducer, surface more often, swim faster, and breathe more forcefully than during the baseline periods. However, the higher the background noise level, the smaller the effects of the sweeps on the surfacing behavior of the porpoise. Therefore, the effects of naval sonar systems on harbor porpoises are determined not only by the received level of the signals and the hearing sensitivity of the animals but also by the background noise. PMID:21476686

  3. 7 CFR 247.16 - Certification period.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.16 Certification period. (a... final day of the month in which eligibility expires (e.g., the last day of the month in which a child... discrimination by race, color, national origin, age, sex, or disability. (Approved by the Office of...

  4. 7 CFR 247.16 - Certification period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.16 Certification period. (a... final day of the month in which eligibility expires (e.g., the last day of the month in which a child... discrimination by race, color, national origin, age, sex, or disability. (Approved by the Office of...

  5. 7 CFR 247.16 - Certification period.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.16 Certification period. (a... final day of the month in which eligibility expires (e.g., the last day of the month in which a child... discrimination by race, color, national origin, age, sex, or disability. (Approved by the Office of...

  6. 42 CFR 408.8 - Grace period and termination date.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MEDICARE PROGRAM PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE General Provisions § 408.8 Grace period and... the billing month. (2) For payments required because the monthly benefit is less than the...

  7. 42 CFR 408.8 - Grace period and termination date.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MEDICARE PROGRAM PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE General Provisions § 408.8 Grace period and... the billing month. (2) For payments required because the monthly benefit is less than the...

  8. 42 CFR 408.8 - Grace period and termination date.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MEDICARE PROGRAM PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE General Provisions § 408.8 Grace period and... the billing month. (2) For payments required because the monthly benefit is less than the...

  9. 42 CFR 408.8 - Grace period and termination date.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MEDICARE PROGRAM PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE General Provisions § 408.8 Grace period and... the billing month. (2) For payments required because the monthly benefit is less than the...

  10. Synthesis, tumor inhibitory and antioxidant activity of new polyfunctionally 2-substituted 5,6,7,8-tetrahydronaphthalene derivatives containing pyridine, thioxopyridine and pyrazolopyridine moieties.

    PubMed

    Hamdy, Nehal A; Anwar, Manal M; Abu-Zied, Khadiga M; Awad, Hanem M

    2013-01-01

    2-Acetyl-5,6,7,8-tetrahydronaphthalene (1) was allowed to react with different aromatic aldehydes to produce the cyanopyridones 2a and 2b, which were treated with phosphorous pentasulfide to afford the corresponding thioxopyridine derivatives 3a and 3b, respectively. The reaction of 3a and 3b with ethyl bromoacetate afforded the ester derivatives 4a and 4b, while their condensation with hydrazine hydrate gave the corresponding pyrazolopyridine derivatives 5a and 5b. The reaction of the precursor 2-amino-5,6,7,8-tetrahydronaphthalene (6) with ethoxy methylenemalonic ester led to the formation of aminomethylenemalonate derivative 7. Cyclization of 7 in boiling diphenyl ether gave the derivative - ethyl 6,7,8,9-tetrahydro-4-hydroxybenzo[g]-quinoline-3-carboxylate (8) which was hydrolyzed to produce the corresponding carboxylic acid analogue 9. Further reaction of 3a with 3-chloropropane-1,2-diol and/or iodomethane produced the corresponding nicotinonitrile derivatives 10 and 11. Hydrazinolysis of derivative 11 gave the hydrazinyl derivative 12. Moreover, chlorination of compound 2a with phosphorous oxychloride led to 2-chloro nicotinonitrile derivative 13, which was refluxed with various amines to form the corresponding derivatives 5a, 14 and 15. Treatment of the pyrazolopyridine compound 5a with formic acid and acetic anhydride afforded the corresponding formamide and acetamide analogues 16 and 17, while its reaction with DMF-DMA yielded the corresponding formimidamide derivative 18. The pyridopyrazolo[1,5-a]pyrimidine derivative 19 was obtained by cyclization of 5a with acetyl acetone. The antioxidant activity evaluation of the newly synthesized compounds showed that the pyrazolopyridine derivative 5a exhibited scavenging potency higher than that obtained by ascorbic acid. Tumor inhibitory activity screening revealed that derivatives 8 and 10 showed promising potency against the liver cancer cells (HepG-2) compared to doxorubicin as a reference drug. PMID:24383322

  11. A new probe of magnetic fields during high-mass star formation. Zeeman splitting of 6.7 GHz methanol masers

    NASA Astrophysics Data System (ADS)

    Vlemmings, W. H. T.

    2008-06-01

    Context: The role of magnetic fields during high-mass star formation is a matter of fierce debate, yet only a few direct probes of magnetic field strengths are available. Aims: The magnetic field is detected in a number of massive star-forming regions through polarization observations of 6.7 GHz methanol masers. Although these masers are the most abundant of the maser species occurring during high-mass star formation, most magnetic field measurements in the high-density gas currently come from OH and H2O maser observations. Methods: The 100-m Effelsberg telescope was used to measure the Zeeman splitting of 6.7 GHz methanol masers for the first time. The observations were performed on a sample of 24 bright northern maser sources. Results: Significant Zeeman splitting is detected in 17 of the sources with an average magnitude of 0.56 m s-1. Using the current best estimate of the 6.7 GHz methanol maser Zeeman splitting coefficient and a geometrical correction, this corresponds to an absolute magnetic field strength of 23 mG in the methanol maser region. Conclusions: The magnetic field is dynamically important in the dense maser regions. No clear relation is found with the available OH maser magnetic field measurements. The general sense of direction of the magnetic field is consistent with other Galactic magnetic field measurements, although a few of the masers display a change of direction between different maser features. Due to the abundance of methanol masers, measuring their Zeeman splitting provides the opportunity to construct a comprehensive sample of magnetic fields in high-mass star-forming regions. Figures 6-8 are only available in electronic form at http://www.aanda.org

  12. Predicted liquefaction in the greater Oakland area and northern Santa Clara Valley during a repeat of the 1868 Hayward Fault (M6.7-7.0) earthquake

    USGS Publications Warehouse

    Holzer, Thomas L.; Noce, Thomas E.; Bennett, Michael J.

    2010-01-01

    Probabilities of surface manifestations of liquefaction due to a repeat of the 1868 (M6.7-7.0) earthquake on the southern segment of the Hayward Fault were calculated for two areas along the margin of San Francisco Bay, California: greater Oakland and the northern Santa Clara Valley. Liquefaction is predicted to be more common in the greater Oakland area than in the northern Santa Clara Valley owing to the presence of 57 km2 of susceptible sandy artificial fill. Most of the fills were placed into San Francisco Bay during the first half of the 20th century to build military bases, port facilities, and shoreline communities like Alameda and Bay Farm Island. Probabilities of liquefaction in the area underlain by this sandy artificial fill range from 0.2 to ~0.5 for a M7.0 earthquake, and decrease to 0.1 to ~0.4 for a M6.7 earthquake. In the greater Oakland area, liquefaction probabilities generally are less than 0.05 for Holocene alluvial fan deposits, which underlie most of the remaining flat-lying urban area. In the northern Santa Clara Valley for a M7.0 earthquake on the Hayward Fault and an assumed water-table depth of 1.5 m (the historically shallowest water level), liquefaction probabilities range from 0.1 to 0.2 along Coyote and Guadalupe Creeks, but are less than 0.05 elsewhere. For a M6.7 earthquake, probabilities are greater than 0.1 along Coyote Creek but decrease along Guadalupe Creek to less than 0.1. Areas with high probabilities in the Santa Clara Valley are underlain by young Holocene levee deposits along major drainages where liquefaction and lateral spreading occurred during large earthquakes in 1868 and 1906.

  13. X-ray Mapping in Heterocyclic Design: XIV. Tricyclic Heterocycles Based on 2-Oxo-1,2,5,6,7,8-Hexahydroquinoline-3-Carbonitrile

    SciTech Connect

    Mazina, O.S.; Rybakov, V.B.; Chernyshev, V.V.; Babaev, E.V.; Aslanov, L.A.

    2004-11-01

    The structures of four compounds are studied using single-crystal X-ray diffraction: 1-[2-(4-chlorophenyl)-2-oxoethyl]-2-oxo-1,2,5,6,7,8-hexahydroquinoline -3-carbonitrile [a = 4.908(4) A, b = 11.644(10) A, c = 13.587(2) A, {beta} = 94.31(5) deg., Z = 2, space group P2{sub 1}]; 2-[2-(4-chlorophenyl)-2-oxoethoxy]-5,6,7,8-tetrahydroquinoline -3-carbonitrile [a = 7.6142(8) A, b = 14.778(2) A, c = 14.132(2) A, {beta} = 100.38(1) deg., Z = 4, space group P2{sub 1}/c]; 4-(aminocarbonyl)-2-(chlorophenyl)-6,7,8,9-tetrahydro[1.3]oxazolo[3,2-a] quinolin-3-ium perchlorate [a = 5.589(7) A, b = 24.724(15) A, c = 13.727(5) A, {beta} = 97.66(9) deg., Z = 4, space group P2{sub 1}/n]; and (3-amino-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-2-yl)-(4-chlorophenyl) methanone [a = 7.150(2) A, b = 7.4288(10) A, c = 15.314(3) A, {alpha} = 98.030(10) deg., {beta} = 99.21(2) deg., {gamma} = 105.34(2) deg., Z = 2, space group P1-bar]. The structures are solved by direct methods and refined by the full-matrix least-squares procedure in the anisotropic approximation to R = 0.0728, 0.0439, 0.1228, and 0.0541, respectively. The structure of 1-(4-chlorophenyl)-4-piperidin-1-yl-8,9-dihydro-7H-pyrrolo[3.2.1-ij] quinoline-5-carboxamide [a = 23.9895(9) A, b = 5.1557(3) A, c = 17.0959(9) A, {beta} = 106.43 deg., Z = 4, space group P{sub 1}/c] is investigated by X-ray powder diffraction. This structure is solved using the grid search procedure and refined by the Rietveld method to R{sub wp} = 0.0773, R{sub exp} = 0.0540, R{sub p} = 0.0585, R{sub b} = 0.1107, and {chi}{sup 2} = 1.78.

  14. Transoral resection of pharyngeal cancer: summary of a National Cancer Institute Head and Neck Cancer Steering Committee Clinical Trials Planning Meeting, November 6-7, 2011, Arlington, Virginia.

    PubMed

    Adelstein, David J; Ridge, John A; Brizel, David M; Holsinger, F Christopher; Haughey, Bruce H; O'Sullivan, Brian; Genden, Eric M; Beitler, Jonathan J; Weinstein, Gregory S; Quon, Harry; Chepeha, Douglas B; Ferris, Robert L; Weber, Randal S; Movsas, Benjamin; Waldron, John; Lowe, Val; Ramsey, Scott; Manola, Judith; Yueh, Bevan; Carey, Thomas E; Bekelman, Justin E; Konski, Andre A; Moore, Eric; Forastiere, Arlene; Schuller, David E; Lynn, Jean; Ullmann, Claudio Dansky

    2012-12-01

    Recent advances now permit resection of many pharyngeal tumors through the open mouth, an approach that can greatly reduce the morbidity of surgical exposure. These transoral techniques are being rapidly adopted by the surgical community and hold considerable promise. On November 6-7, 2011, the National Cancer Institute sponsored a Clinical Trials Planning Meeting to address how to further investigate the use of transoral surgery, both in the good prognosis human papillomavirus (HPV)-initiated oropharyngeal cancers, and in those with HPV-unrelated disease. The proceedings of this meeting are summarized. PMID:23015475

  15. Enantioselective route to 5-methyl- and 5,7-dimethyl-6,7-dihydro-5H-dibenz[c,e]azepine: secondary amines with switchable axial chirality.

    PubMed

    Pira, Silvain L; Wallace, Timothy W; Graham, Jonathan P

    2009-04-01

    (-)-5-Methyl-6,7-dihydro-5H-dibenz[c,e]azepine 4, a new secondary amine featuring an axis-center stereochemical relay, was prepared enantioselectively from 2'-acetylbiphenyl-2-carboxylic acid, using (R)-2-phenylglycinol as an auxiliary for the control of both elements of chirality. The biaryl axis in 4 preferentially adopts the aS-configuration, with the methyl substituent pseudoequatorial, but conversion into the corresponding N-Boc derivative locks the axis into the aR-configuration, as predicted on the basis of molecular mechanics calculations. PMID:19275220

  16. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors.

    PubMed

    Asano, Shigehiro; Komiya, Masafumi; Koike, Nobuyuki; Koga, Erina; Nakatani, Shogo; Isobe, Yoshiaki

    2010-11-15

    A novel series of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines containing substituted phenyl sulfonamide are synthesized and evaluated for their inhibitory activity against CaMKII. Substituents on the phenyl group had significant impact on CaMKII inhibition, in particular, the inhibitory activity of 8p was 25-fold higher than that of KN-93, a known CaMKII inhibitor. Michaelis-Menten analysis of a representative compound suggested that the synthesized pyrimidines are calmodulin non-competitive inhibitors. Finally, 8p exhibited more than 100-fold higher selectivity for CaMKII over five types of off-target kinases. PMID:20875738

  17. 3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model.

    PubMed

    Okuyama, Satoshi; Morita, Mayu; Miyoshi, Kazuhiro; Nishigawa, Yuki; Kaji, Miki; Sawamoto, Atsushi; Terugo, Tsukasa; Toyoda, Nobuki; Makihata, Nahomi; Amakura, Yoshiaki; Yoshimura, Morio; Nakajima, Mitsunari; Furukawa, Yoshiko

    2014-05-01

    The present study evaluated the effects of treatment with the citrus flavonoid, 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) on protection against memory impairment and neuronal death in a global cerebral ischemia mouse model. The results showed that HMF, administrated for three days immediately after ischemic surgery, protected against ischemia-induced memory dysfunction, rescued neuronal cell death in the CA1 cell layer, increased the production of BDNF, stimulated the autophosphorylation of CaMK II and suppressed microglial activation in the hippocampus. These results suggest that HMF has a neuroprotective effect after brain ischemia by inducing BDNF production and anti-inflammatory effects. PMID:24657445

  18. Synthesis, structure-activity relationships and biological evaluation of 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 negative allosteric modulators.

    PubMed

    Hirose, Wataru; Kato, Yoshihiro; Yamamoto, Takayoshi; Kassai, Momoe; Takata, Makoto; Hayashi, Shun; Arai, Yukiyo; Imai, Satoki; Yoshida, Kohzo

    2016-08-15

    The design, synthesis and SAR studies of novel 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulators (NAMs) are presented in this letter. Starting from a HTS hit compound (1, IC50=477nM), optimization of various groups led to the synthesis of a potent mGluR5 NAM (32, IC50=75nM) with excellent rat PK profile and good brain penetration. This compound produced oral antidepressant-like effect in a mouse tale suspension model (MED: 30mg/kg). PMID:27432763

  19. Crystal structure of 2-amino-7,7-dimethyl-5-oxo-4-(pyridin-4-yl)-5,6,7,8-tetrahydro-4 H-chromene-3-carbonitrile hemihydrate

    NASA Astrophysics Data System (ADS)

    Sharma, N.; Banerjee, B.; Brahmachari, G.; Kant, R.; Gupta, V. K.

    2015-12-01

    The title compound, 2-amino-7,7-dimethyl-5-oxo-4-(pyridin-4-yl)-5,6,7,8-tetrahydro-4 Hchromene-3-carbonitrile was synthesized by multicomponent reaction at room temperature using commercially available urea as inexpensive and environmentally benign organo-catalyst. Its structure was determined by X-ray structure analysis. The crystals are monoclinic, sp. gr. C2/ c, a = 22.010(6), b = 11.0364(10), c = 17.147(4) Å, β = 130.37(4)°, Z = 8, R = 0.0433 for 2377 observed reflections.

  20. Breakup coupling effects on near-barrier quasi-elastic scattering of {sup 6,7}Li on {sup 144}Sm

    SciTech Connect

    Otomar, D. R.; Lubian, J.; Gomes, P. R. S.; Monteiro, D. S.; Niello, J. O. Fernandez; Guimaraes, V.; Chamon, L. C.

    2009-09-15

    Excitation functions of quasi-elastic scattering at backward angles have been measured for the {sup 6,7}Li+{sup 144}Sm systems at near-barrier energies, and fusion barrier distributions have been extracted from the first derivatives of the experimental cross sections with respect to the bombarding energies. The data have been analyzed in the framework of continuum discretized coupled-channel calculations, and the results have been obtained in terms of the influence exerted by the inclusion of different reaction channels, with emphasis on the role played by the projectile breakup.

  1. Large-Scale Synthesis of Crystalline 1,2,3,4,6,7-Hexa-O-acetyl-l-glycero-α-d-manno-heptopyranose

    PubMed Central

    Stanetty, Christian; Baxendale, Ian R

    2015-01-01

    The higher-carbon sugar l-glycero-d-manno-heptose is a major constituent of the inner core region of the lipopolysaccharide (LPS) of many Gram-negative bacteria. All preparative routes used to date require multiple steps, and scalability has been rarely addressed. Here a highly practical synthesis of crystalline 1,2,3,4,6,7-hexa-O-acetyl-l-glycero-α-d-manno-heptopyranose by a simple four-step sequence starting from l-lyxose is disclosed. Only two recrystallisations are required and the process was demonstrated on a >100 mmol scale, yielding 41 g of the target compound. PMID:26097405

  2. 19 CFR 127.4 - General order period defined.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false General order period defined. 127.4 Section 127.4... order period defined. The general order period is that period of time during which general order merchandise, as defined in § 127.1, is not subject to sale. The general order period expires 6 months from...

  3. Teen Programs with Punch: A Month-by-Month Guide

    ERIC Educational Resources Information Center

    Ott, Valerie A.

    2006-01-01

    This book provides a stimulating selection of year-round program ideas that appeal to teens between the ages of 12 and 18. Organized by month, the programs represent a broad range of interests, from arts and crafts workshops to educational programs to purely recreational activities--from serious to serious fun. A few representative ideas: "Goth…

  4. Monthly energy review, July 1994

    SciTech Connect

    Not Available

    1994-07-26

    Energy production during April 1994 totaled 5.5 quadrillion Btu, a 2.2-percent increase from the level of production during April 1993. Coal production increased 11.8 percent, petroleum production fell 4.0 percent, and natural gas production decreased 0.3 percent. All other forms of energy production combined were down 2.9 percent from the level of production during April 1993. Energy consumption during April 1994 totaled 6.7 quadrillion Btu, 1.4 percent above the level of consumption during April 1993. Petroleum consumption increased 3.9 percent, coal consumption rose 1.1 percent, and natural gas consumption decreased 1.5 percent. Consumption of all other forms of energy combined decreased 0.4 percent from the level 1 year earlier. Net imports of energy during April 1994 totaled 1.5 quadrillion Btu, 8.7 percent above the level of net imports 1 year earlier. Net imports of petroleum increased 4.5 percent, and net imports of natural gas were up 18.5 percent. Net exports of coal fell 9.2 percent from the level in April 1993.

  5. Monthly energy review, June 1994

    SciTech Connect

    Not Available

    1994-06-01

    Energy production during March 1994 totaled 5.9 quadrillion Btu, a 3.7-percent increase from the level of production during March 1993. Coal production increased 15.7 percent, petroleum production fell 4.1 percent, and natural gas production decreased 1.1 percent. All other forms of energy production combined were up 0.5 percent from the level of production during March 1993. Energy consumption during March 1994 totaled 7.5 quadrillion Btu, 1.3 percent below the level of consumption during March 1993. Natural gas consumption decreased 3.6 percent, petroleum consumption fell 1.6 percent, and coal consumption remained the same. Consumption of all other forms of energy combined increased 3.7 percent from the level 1 year earlier. Net imports of energy during March 1994 totaled 1.5 quadrillion Btu, 6.7 percent above the level of net imports 1 year earlier. Net imports of petroleum increased 3.2 percent, and net imports of natural gas were up 15.7 percent. Net exports of coal rose 2.1 percent from the level in March 1993.

  6. Monthly energy review, July 1990

    SciTech Connect

    Not Available

    1990-10-29

    US total energy consumption in July 1990 was 6.7 quadrillion Btu Petroleum products accounted for 42 percent of the energy consumed in July 1990, while coal accounted for 26 percent and natural gas accounted for 19 percent. Residential and commercial sector consumption was 2.3 quadrillion Btu in July 1990, up 2 percent from the July 1989 level. The sector accounted for 35 percent of July 1990 total consumption, about the same share as in July 1989. Industrial sector consumption was 2.4 quadrillion Btu in July 1990, up 2 percent from the July 1989 level. The industrial sector accounted for 36 percent of July 1990 total consumption, about the same share as in July 1989. Transportation sector consumption of energy was 1.9 quadrillion Btu in July 1990, up 1 percent from the July 1989 level. The sector consumed 29 percent of July 1990 total consumption, about the same share as in July 1989. Electric utility consumption of energy totaled 2.8 quadrillion Btu in July 1990, up 2 percent from the July 1989 level. Coal contributed 53 percent of the energy consumed by electric utilities in July 1990, while nuclear electric power contributed 21 percent; natural gas, 12 percent; hydroelectric power, 9 percent; petroleum, 5 percent; and wood, waste, geothermal, wind, photovoltaic, and solar thermal energy, about 1 percent.

  7. Monthly energy review, January 1994

    SciTech Connect

    Not Available

    1994-01-01

    This publication contains statistical information and data analysis of energy production and consumption within the major energy industries of petroleum, natural gas, coal, electricity, nuclear energy and oil and gas resource development. Energy production during October 1993 totaled 5.5-quadrillion Btu, a 3.0 percent decrease from the level of production during October 1992. Coal production decreased 5.6 percent, petroleum production decreased 3.4 percent, and natural gas production increased 1.9 percent. All other forms of energy production combined were down 6.0 percent from the level of production during October 1992. Energy consumption during October 1993 totaled 6.7 quadrillion Btu, 0.9 percent above the level of consumption during October 1992. Natural gas consumption increased 6.5 percent, coal consumption rose 2.9 percent, and petroleum consumption was down 1.3 percent. Consumption of all other forms of energy combined decreased 5.5 percent from the level of 1 year earlier.

  8. Monthly energy review, May 1997

    SciTech Connect

    1997-05-01

    This is an overview of the May energy statistics by the Energy Information Administration. The contents of the report include an energy overview, US energy production, trade stocks and prices for petroleum, natural gas, oil and gas resource development, coal, electricity, nuclear energy, energy prices, and international energy. Energy production during February 1997 totaled 5.4 quadrillion Btu, a 1.9% decrease from the level of production during February 1996. Coal production increased 1.2%, natural gas production decreased 2.9%, and production of crude oil and natural gas plant liquids decreased 2.1%. All other forms of energy production combined were down 6.3% from the level of production during February 1996. Energy consumption during February 1997 totaled 7.5 quadrillion Btu, 4.0% below the level of consumption during February 1996. Consumption of petroleum products decreased 4.4%, consumption of natural gas was down 3.5%, and consumption of coal fell 2.2%. Consumption of all other forms of energy combined decreased 6.7% from the level 1 year earlier. Net imports of energy during February 1997 totaled 1.5 quadrillion Btu, 14.1% above the level of net imports 1 year earlier. Net imports of petroleum increased 12.7% and net imports of natural gas were up 7.4%. Net exports of coal fell 12.1% from the level in February 1996. 37 figs., 75 tabs.

  9. Natural gas monthly, April 1998

    SciTech Connect

    1998-04-01

    This issue of the Natural Gas Monthly presents the most recent estimates of natural gas data from the Energy Information Administration (EIA). Estimates extend through April 1998 for many data series. The report highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, feature articles are presented designed to assist readers in using and interpreting natural gas information. This issue contains the special report, ``Natural Gas 1997: A Preliminary Summary.`` This report provides information on natural gas supply and disposition for the year 1997, based on monthly data through December from EIA surveys. 6 figs., 28 tabs.

  10. Electric power monthly, May 1994

    SciTech Connect

    Not Available

    1994-05-01

    The Electric Power Monthly (EPM) presents monthly electricity statistics. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. Data in this report are presented for a wide audience including Congress, Federal and State agencies, the electric utility industry, and the general public. This publication provides monthly statistics for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of fossil fuels, electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Statistics by company and plant are published on the capability of new generating units, net generation, fuel consumption, fuel stocks, quantity and quality of fuel, and cost of fossil fuels.

  11. Electric power monthly, September 1993

    SciTech Connect

    Not Available

    1993-09-17

    The Electric Power Monthly (EPM) presents monthly electricity statistics. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. The EPM is prepared by the Survey Management Division; Office of Coal, Nuclear, Electric and Alternate Fuels, Energy Information Administration (EIA), Department of Energy. This publication provides monthly statistics at the US, Census division, and State levels for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of fossil fuels, electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Data on net generation, fuel consumption, fuel stocks, quantity and cost of fossil fuels are also displayed for the North American Electric Reliability Council (NERC) regions.

  12. Electric power monthly, August 1993

    SciTech Connect

    Not Available

    1993-08-13

    The Electric Power Monthly (EPM) presents monthly electricity statistics. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. The EPM is prepared by the Survey Management Division; Office of Coal, Nuclear, Electric and Alternate Fuels, Energy Information Administration (EIA), Department of Energy. This publication provides monthly statistics at the US, Census division, and State levels for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of fossil fuels, electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Data on net generation, fuel consumption, fuel stocks, quantity and cost of fossil fuels are also displayed for the North American Electric Reliability Council (NERC) regions.

  13. Electric power monthly, April 1994

    SciTech Connect

    Not Available

    1994-04-01

    The Electric Power Monthly (EPM) presents monthly electricity statistics. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. This publication provides monthly statistics at the U.S., Census division, and State levels for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of fossil fuels, electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Data on net generation, fuel consumption, fuel stocks, quantity and cost of fossil fuels are also displayed for the North American Electric Reliability Council (NERC) regions. This April 1994 issue contains 1993 year-end data and data through January 1994.

  14. Electric power monthly, June 1994

    SciTech Connect

    Not Available

    1994-06-01

    The Electric Power Monthly (EPM) presents monthly electricity statistics. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. Data in this report are presented for a wide audience including Congress, Federal and State agencies, the electric utility industry, and the general public. The EIA collected the information in this report to fulfill its data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 (Public Law 93-275) as amended.

  15. Petroleum marketing monthly, May 1994

    SciTech Connect

    Not Available

    1994-05-26

    The Petroleum Marketing Monthly (PMM) provides information and statistical data on a variety of crude oils and refined petroleum products. The publication presents statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, petroleum product sales data include motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane. The Petroleum Marketing Division, Office of Oil and Gas, Energy Information Administration ensures the accuracy, quality, and confidentiality of the published data in the Petroleum Marketing Monthly.

  16. Natural gas monthly, August 1993

    SciTech Connect

    Not Available

    1993-08-25

    The Natural Gas Monthly (NGM) is prepared in the Data Operations Branch of the Reserves and Natural Gas Division, Office of Oil and Gas, Energy Information Administration (EIA), US Department of Energy (DOE). The NGM highhghts activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  17. Natural gas monthly, October 1996

    SciTech Connect

    1996-10-01

    The Natural Gas Monthly (NGM) is prepared in the Data Operations Branch of the Reserves and Natural Gas Division, Office of Oil and Gas, Energy Information Administration (EIA), U.S. Department of Energy (DOE). The NGM highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  18. Natural gas monthly, April 1997

    SciTech Connect

    1997-04-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are present3ed each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. The feature article is entitled ``Natural gas pipeline and system expansions.`` 6 figs., 27 tabs.

  19. Natural gas monthly, October 1997

    SciTech Connect

    1997-10-01

    The Natural Gas Monthly highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. The feature article in this issue is a special report, ``Comparison of Natural Gas Storage Estimates from the EIA and AGA.`` 6 figs., 26 tabs.

  20. Monthly energy review, July 1999

    SciTech Connect

    1999-07-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. The MER is intended for use by Members of Congress, Federal and State agencies, energy analysts, and the general public. EIA welcomes suggestions from readers regarding data series in the MER and in other EIA publications. 37 figs., 75 tabs.

  1. Electric power monthly, July 1993

    SciTech Connect

    Not Available

    1993-07-29

    The Electric Power Monthly (EPM) presents monthly electricity statistics. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. Data in this report are presented for a wide audience including Congress, Federal and State agencies, the electric utility industry, and the general public. The EIA collected the information in this report to fulfill its data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 (Public Law 93-275) as amended.

  2. Electric power monthly, May 1993

    SciTech Connect

    Not Available

    1993-05-25

    The Electric Power Monthly (EPM) is prepared by the Survey Management Division; Office of Coal, Nuclear, Electric and Alternate Fuels, Energy Information Administration (EIA), Department of Energy. This publication provides monthly statistics at the US, Census division, and State levels for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of fossil fuels, electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Data on net generation, fuel consumption, fuel stocks, quantity and cost of fossil fuels are also displayed for the North American Electric Reliability Council (NERC) regions.

  3. Electric power monthly, April 1993

    SciTech Connect

    Not Available

    1993-05-07

    The Electric Power Monthly is prepared by the Survey Management Division; Office of Coal, Nuclear, Electric and Alternate Fuels, Energy Information Administration (EIA), Department of Energy. This publication provides monthly statistics at the US, Census division, and State levels for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of fossil fuels, electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Data on net generation, fuel consumption, fuel stocks, quantity and cost of fossil fuels are also displayed for the North American Electric Reliability Council (NERC) regions.

  4. Natural gas monthly, April 1999

    SciTech Connect

    1999-05-06

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. There are two feature articles in this issue: Natural gas 1998: Issues and trends, Executive summary; and Special report: Natural gas 1998: A preliminary summary. 6 figs., 28 tabs.

  5. Natural gas monthly, September 1993

    SciTech Connect

    Not Available

    1993-09-27

    The Natural Gas Monthly (NGM) is prepared in the Data Operations Branch of the Reserves and Natural Gas Division, Office of Oil and Gas, Energy Information Administration (EIA), US Department of Energy (DOE). The NGM highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  6. Electric power monthly, August 1994

    SciTech Connect

    Not Available

    1994-08-24

    The Electric Power Monthly (EPM) presents monthly electricity statistics. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. Data in this report are presented for a wide audience including Congress, Federal and State agencies, the electric utility industry, and the general public. The EIA collected the information in this report to fulfill its data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 (Public Law 93-275) as amended.

  7. Monthly energy review, June 1999

    SciTech Connect

    1999-06-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. The MER is intended for use by Members of Congress, Federal and State agencies, energy analysts, and the general public. EIA welcomes suggestions from readers regarding data series in the MER and in other EIA publications. 37 figs., 61 tabs.

  8. Natural gas monthly, March 1994

    SciTech Connect

    Not Available

    1994-03-22

    The Natural Gas Monthly (NGM) is prepared in the Data Operations Branch of the Reserves and Natural Gas Division, Office of Oil and Gas, Energy Information Administration (EIA), US Department of energy (DOE). The NGM highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  9. Design and Synthesis of 2-(3-Benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one Analogs as Potent Antitumor Agents that Inhibit Tubulin Assembly

    PubMed Central

    Chang, Yu-Hsun; Hsu, Mei-Hua; Wang, Sheng-Hung; Huang, Li-Jiau; Qian, Keduo; Morris-Natschke, Susan L.; Hamel, Ernest; Kuo, Sheng-Chu; Lee, Kuo-Hsiung

    2009-01-01

    As part of our continuing investigation of azo-flavonoid derivatives as potential anticancer drug candidates, a series of 2-aryl-6,7-methylenedioxyquinolin-4-one analogs was designed and synthesized. The design combined structural features of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1), a previously discovered compound with potent in vivo antitumor activity, and 2-arylquinolin-4-ones identified by CoMFA models. The newly synthesized analogs were evaluated for cytotoxicity against seven human cancer cell lines, and structure-activity relationship (SAR) correlations were established. Analogs 1, 37, and 39 showed potent cytotoxicity against different cancer cell lines. Compound 1 demonstrated selective cytotoxicity against Hep 3B (hepatoma) cells. Compound 37 was cytotoxic against HL-60 (leukemia), HCT-116 (colon cancer), Hep 3B (hepatoma), and SK-MEL-5 (melanoma) cells. Compound 39 exhibited broad cytotoxicity against all seven cancer cell lines, with IC50 values between 0.07–0.19 µM. Results from mechanism of action studies revealed that these new quinolone derivatives function as antitubulin agents. PMID:19719238

  10. Hearing thresholds of a harbor porpoise (Phocoena phocoena) for sweeps (1-2 kHz and 6-7 kHz bands) mimicking naval sonar signals.

    PubMed

    Kastelein, Ronald A; Hoek, Lean; de Jong, Christ A F

    2011-05-01

    The distance at which active naval sonar signals can be heard by harbor porpoises depends, among other factors, on the hearing thresholds of the species for those signals. Therefore the hearing sensitivity of a harbor porpoise was determined for 1 s up-sweep and down-sweep signals, mimicking mid-frequency and low-frequency active sonar sweeps (MFAS, 6-7 kHz band; LFAS, 1-2 kHz band). The 1-2 kHz sweeps were also tested with harmonics, as sonars sometimes produce these as byproducts of the fundamental signal. The hearing thresholds for up-sweeps and down-sweeps within each sweep pair were similar. The 50% detection threshold sound pressure levels (broadband, averaged over the signal duration) of the 1-2 kHz and 6-7 kHz sweeps were 75 and 67 dB re 1 μPa(2), respectively. Harmonic deformation of the 1-2 kHz sweeps reduced the threshold to 59 dB re 1 μPa(2). This study shows that the presence of harmonics in sonar signals can increase the detectability of a signal by harbor porpoises, and that tonal audiograms may not accurately predict the audibility of sweeps. LFAS systems, when designed to produce signals without harmonics, can operate at higher source levels than MFAS systems, at similar audibility distances for porpoises. PMID:21568440

  11. A Biomechanical Comparison of Intralaminar C7 Screw Constructs with and without Offset Connector Used for C6-7 Cervical Spine Immobilization : A Finite Element Study

    PubMed Central

    Qasim, Muhammad; Natarajan, Raghu N.; An, Howard S.

    2013-01-01

    Objective The offset connector can allow medial and lateral variability and facilitate intralaminar screw incorporation into the construct. The aim of this study was to compare the biomechanical characteristics of C7 intralaminar screw constructs with and without offset connector using a three dimensional finite element model of a C6-7 cervical spine segment. Methods Finite element models representing C7 intralaminar screw constructs with and without the offset connector were developed. Range of motion (ROM) and maximum von Mises stresses in the vertebra for the two techniques were compared under pure moments in flexion, extension, lateral bending and axial rotation. Results ROM for intralaminar screw construct with offset connector was less than the construct without the offset connector in the three principal directions. The maximum von Misses stress was observed in the C7 vertebra around the pedicle in both constructs. Maximum von Mises stress in the construct without offset connector was found to be 12-30% higher than the corresponding stresses in the construct with offset connector in the three principal directions. Conclusion This study demonstrated that the intralaminar screw fixation with offset connector is better than the construct without offset connector in terms of biomechanical stability. Construct with the offset connector reduces the ROM of C6-7 segment more significantly compared to the construct without the offset connector and causes lower stresses around the C7 pedicle-vertebral body complex. PMID:24003366

  12. Design, Synthesis and Biological Evaluation of 5-Oxo-1,4,5,6,7,8 Hexahydroquinoline Derivatives as Selective Cyclooxygenase-2 Inhibitors

    PubMed Central

    Zarghi, Afshin; Sabakhi, Iman; Topuzyan, Vigen; Hajimahdi, Zahra; Daraie, Bahram

    2014-01-01

    A group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a COX-2 SO2Me pharmacophore at the para position of the C-2 or C-4 phenyl ring, in conjunction with a C-4 or C-2 phenyl (4-H) or substituted-phenyl ring (4-F,4-Cl,4-Br,4-OMe,4-Me, 4-NO2), were designed for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors. These target 5-oxo-1,4,5,6,7,8 hexahydroquinolines were synthesized via a Hansch condensation reaction. In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 7,8-dihydro- 7,7-dimethyl-2-(4-methoxyphenyl)-4-(4-(methylsulfonyl)phenyl)quinolin-5(1H,4H,6H)- one (9c) as a potent COX-2 inhibitor (IC50 = 0.17 M) with a high COX-2 selectivity index (S.I. = 97.6) comparable to the reference drug celecoxib (COX-2 IC50 = 0.05 mM; COX-2 S.I= 405). A molecular modeling study where 9c was docked in active site of COX-2 showed that the p-SO2Me substituent on the C-2 phenyl ring is inserted into the secondary COX-2 binding site. The structure activity data acquired indicate that the position of the COX-2 SO2Me pharmacophore and type of substituent are important for COX-2 inhibitory activity. PMID:24711830

  13. Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles.

    PubMed

    Santos, Kathleen; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana F; Gonçalves, Cristina; Sarmento Ribeiro, Ana Bela; Botelho, M Filomena; Soares, Maria I L; Oliveira, Andreia S R; Pinho e Melo, Teresa M V D

    2014-05-22

    Further studies on 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles as anticancer agents against breast cancer are reported, allowing to demonstrate the potential of these compounds for the therapy of the triple-negative breast cancer, the most challenging tumors in clinical practice. These compounds were assayed for their in vitro cytotoxicity on several human breast cancer cell lines (MCF7, HCC1954 and HCC1806 cell lines). Particularly interesting were the results obtained for 4-hydroxyphenyl substituted derivative, which proved to be the most promising compound regarding HCC1806 cell line, a triple-negative breast cancer. The effects of the two most active compounds on cell survival, viability, cell cycle, DNA damage and expression of proteins related to cell death pathways were studied. The reported results consolidate the potential of 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles for the therapy of breast cancer, particularly the triple-negative. PMID:24747064

  14. Behavioral responses of herring (Clupea harengus) to 1-2 and 6-7 kHz sonar signals and killer whale feeding sounds.

    PubMed

    Doksaeter, Lise; Rune Godo, Olav; Olav Handegard, Nils; Kvadsheim, Petter H; Lam, Frans-Peter A; Donovan, Carl; Miller, Patrick J O

    2009-01-01

    Military antisubmarine sonars produce intense sounds within the hearing range of most clupeid fish. The behavioral reactions of overwintering herring (Clupea harengus) to sonar signals of two different frequency ranges (1-2 and 6-7 kHz), and to playback of killer whale feeding sounds, were tested in controlled exposure experiments in Vestfjorden, Norway, November 2006. The behavior of free ranging herring was monitored by two upward-looking echosounders. A vessel towing an operational naval sonar source approached and passed over one of them in a block design setup. No significant escape reactions, either vertically or horizontally, were detected in response to sonar transmissions. Killer whale feeding sounds induced vertical and horizontal movements of herring. The results indicate that neither transmission of 1-2 kHz nor 6-7 kHz have significant negative influence on herring on the received sound pressure level tested (127-197 and 139-209 dB(rms) re 1 microPa, respectively). Military sonars of such frequencies and source levels may thus be operated in areas of overwintering herring without substantially affecting herring behavior or herring fishery. The avoidance during playback of killer whale sounds demonstrates the nature of an avoidance reaction and the ability of the experimental design to reveal it. PMID:19173441

  15. 6,7-Dihydroxyisoindolin-1-one and 7,8-Dihydroxy-3,4-Dihydroisoquinolin- 1(2H)-one Based HIV-1 Integrase Inhibitors.

    PubMed

    Zhao, Xue Zhi; Metifiot, Mathieu; Smith, Steven J; Maddali, Kasthuraiah; Marchand, Christophe; Hughes, Stephen H; Pommier, Yves; Burke, Terrence R

    2016-01-01

    Integrase (IN) is an essential viral enzyme required for HIV-1 replication, which has been targeted by anti-AIDS therapeutics. Integrase strand transfer inhibitors (INSTIs) represent a new class of antiretroviral agents developed for the treatment of HIV-1 infections. Important structural features that are shared by many INSTIs include a coplanar arrangement of three heteroatoms that chelate two catalytic Mg(2+) ions in the IN active site and a linked halophenyl ring that binds in the hydrophobic pocket formed by the complex of IN with viral DNA. We recently reported bicyclic 6,7-dihydroxyoxoisoindolin-1-one-based IN inhibitors. In the current study, we modified these inhibitors in three ways. First, we increased the spacer length between the metalchelating triad and the halophenyl group. Second, we replaced the indoline [5,6] bicycle with a fused dihydroxyisoquinolinones [6,6] ring system. Finally, we prepared bis-6,7-dihydroxyisoindolin-1-one-4-sulfonamides as dimeric HIV-1 IN inhibitors. These new analogues showed low micromolar inhibitory potency in in vitro HIV-1 integrase assays. PMID:26268341

  16. INTRACELLULAR ANTIOXIDANT ACTIVITY OF A STREPTOMYCES SP. 8812 SECONDARY METABOLITE, 6,7-DIHYDROXY-3,4-DIHYDROISOQINO- LINE-3-CARBOXYLIC ACID, AND ITS SYNTHETIC DERIVATIVES.

    PubMed

    Guśpiel, Adam; Ziemska, Joanna; Cześcik, Agnieszka; Kawecki, Robert; Solecka, Jolanta

    2016-01-01

    The aim of this study was to determine the antioxidant properties of 6,7-dihydroxy-3,4-dihydroiso- quinoline-3-carboxylic acid (1) and its derivatives in living cells against reactive forms of oxygen and nitrogen, i.e., hydrogen peroxide and nitric oxide. Four of tested compounds scavenged the reactive form of nitrogen more efficiently or similarly to Trolox (EC50 = 55.80 µM). Two compounds exhibited antioxidant activity against reactive oxygen species better than Trolox (EC50 = 51.88 µM). The most active derivative of 1 was the compound containing an iodine atom at position 8 (6,7-dihydroxy-8-iodo-3,4-dihydroisoquinoline-3-carboxylic acid). Our studies showed that some of the derivatives had the ability to cross the cell membrane and scavenge free radicals inside living cells. Thus, they are able to protect DNA and other cellular structures from the dam- aging effects of reactive oxygen and nitrogen species. In addition, some molecular descriptors of the tested compounds were determined with the use of ICM Pro (Molsoft L.L.C.). PMID:27476282

  17. Suppression of Adipogenesis by 5-Hydroxy-3,6,7,8,3',4'-Hexamethoxyflavone from Orange Peel in 3T3-L1 Cells.

    PubMed

    Wang, Yu; Lee, Pei-Sheng; Chen, Yi-Fen; Ho, Chi-Tang; Pan, Min-Hsiung

    2016-09-01

    We reported previously that hydroxylated polymethoxyflavones (HPMFs) effectively suppressed obesity in high-fat-induced mouse. In this study, we further investigated the molecular mechanism of action of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF), one of major HPMFs in orange peel. Treatment of 5-OH-HxMF effectively inhibited lipid accumulation by 55-60% in a dose-dependent manner. The 5-OH-HxMF attenuated adipogenesis through downregulating adipogenesis-related transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding proteins (C/EBPs), as well as downstream target fatty acid synthase and acetyl-CoA carboxylase (ACC). 5-OH-HxMF activated adenosine monophosphate-activated protein kinase signaling and silent mating type information regulation 1 (SIRTUIN 1 or SIRT1) in 3T3-L1 adipocytes to decrease lipid accumulation. In addition, the inhibition rate of lipid accumulation was compared between 5-OH-HxMF and 3,5,6,7,8,3',4'-heptamethoxyflavone (HpMF). 5-OH-HxMF inhibited lipid accumulation 15-20% more than HpMF did, indicating that hydroxyl group at position 5 can be a key factor in the suppression of adipogenesis. PMID:27542074

  18. Continuous flow atmospheric pressure laser desorption/ionization using a 6-7-µm-band mid-infrared tunable laser for biomolecular mass spectrometry.

    PubMed

    Hiraguchi, Ryuji; Hazama, Hisanao; Senoo, Kenichirou; Yahata, Yukinori; Masuda, Katsuyoshi; Awazu, Kunio

    2014-01-01

    A continuous flow atmospheric pressure laser desorption/ionization technique using a porous stainless steel probe and a 6-7-µm-band mid-infrared tunable laser was developed. This ion source is capable of direct ionization from a continuous flow with a high temporal stability. The 6-7-µm wavelength region corresponds to the characteristic absorption bands of various molecular vibration modes, including O-H, C=O, CH3 and C-N bonds. Consequently, many organic compounds and solvents, including water, have characteristic absorption peaks in this region. This ion source requires no additional matrix, and utilizes water or acetonitrile as the solvent matrix at several absorption peak wavelengths (6.05 and 7.27 µm, respectively). The distribution of multiply-charged peptide ions is extremely sensitive to the temperature of the heated capillary, which is the inlet of the mass spectrometer. This ionization technique has potential for the interface of liquid chromatography/mass spectrometry (LC/MS). PMID:24937686

  19. Monthly energy review, April 1994

    SciTech Connect

    Not Available

    1994-04-01

    The Monthly Energy Review contains statistical data on the following: energy consumption, petroleum, natural gas, oil and gas resource development, coal, electricity, nuclear energy, energy prices, and international energy. In addition, an energy overview is provided, and, for the April issue, Energy use and carbon emissions; Some international comparisons.

  20. Prediction of Malaysian monthly GDP

    NASA Astrophysics Data System (ADS)

    Hin, Pooi Ah; Ching, Soo Huei; Yeing, Pan Wei

    2015-12-01

    The paper attempts to use a method based on multivariate power-normal distribution to predict the Malaysian Gross Domestic Product next month. Letting r(t) be the vector consisting of the month-t values on m selected macroeconomic variables, and GDP, we model the month-(t+1) GDP to be dependent on the present and l-1 past values r(t), r(t-1),…,r(t-l+1) via a conditional distribution which is derived from a [(m+1)l+1]-dimensional power-normal distribution. The 100(α/2)% and 100(1-α/2)% points of the conditional distribution may be used to form an out-of sample prediction interval. This interval together with the mean of the conditional distribution may be used to predict the month-(t+1) GDP. The mean absolute percentage error (MAPE), estimated coverage probability and average length of the prediction interval are used as the criterions for selecting the suitable lag value l-1 and the subset from a pool of 17 macroeconomic variables. It is found that the relatively better models would be those of which 2 ≤ l ≤ 3, and involving one or two of the macroeconomic variables given by Market Indicative Yield, Oil Prices, Exchange Rate and Import Trade.

  1. Natural gas monthly, July 1990

    SciTech Connect

    Not Available

    1990-10-03

    This report highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. A glossary is included. 7 figs., 33 tabs.

  2. Monthly energy review, November 1993

    SciTech Connect

    Not Available

    1993-11-24

    The Monthly Energy Review gives information on production, distribution, and consumption for various energy sources, e.g. petroleum, natural gas, oil, coal, electricity, and nuclear energy. Some data is also included on international energy sources and supplies, the import of petroleum products into the US and pricing and reserves data (as applicable) for the various sources of energy listed above.

  3. "The Most Important Nine Months."

    ERIC Educational Resources Information Center

    Rhine, Samuel A.

    1983-01-01

    "The Most Important Nine Months of Your Life" is a program that zeroes in on causes and prevention of birth defects. Program content and instructional strategies are discussed. Topics covered include: birth defects, genetic causes of birth defects, errors during development, environmental influences, and development. Includes list of preventive…

  4. Monthly energy review, June 1990

    SciTech Connect

    Not Available

    1990-09-26

    The Monthly Energy Review presents current data on production, consumption, stocks, imports, exports, and prices of the principal energy commodities in the United States. Also included are data on international production of crude oil, consumption of petroleum products, petroleum stocks, and production of electricity from nuclear-powered facilities.

  5. Celebrating White Cane Awareness Month.

    ERIC Educational Resources Information Center

    Koch, Judy; McGraw, Jane M.

    1995-01-01

    White Cane Awareness Month was created to teach the public that the long cane is a tool for maintaining independence and dignity and a symbol of freedom, not of pity or helplessness. Public relations materials were developed, including a demonstration for television stations on use of the long cane and a quiz to distribute at information booths.…

  6. Natural gas monthly, August 1990

    SciTech Connect

    Not Available

    1990-11-05

    This report highlights activities, events, and analyses of interest to public and private sector oganizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. 33 tabs.

  7. Monthly energy review, June 1993

    SciTech Connect

    Not Available

    1993-06-25

    The Monthly Energy Review provides an overview of the production, distribution, and consumption of energy derived from petroleum, natural gas, coal, electricity, and nuclear energy. It also discusses oil and gas resource development, energy prices, and issues relevant to international energy markets.

  8. Monthly energy review, May 1993

    SciTech Connect

    Not Available

    1993-05-01

    The Monthly Energy Review provides an overview of the production, distribution, and consumption of energy derived from petroleum natural gas, coal, electricity, and nuclear energy. It also discusses oil and gas resource development, energy prices, and issues relevant to international energy markets.

  9. Monthly energy review, November 1995

    SciTech Connect

    1995-11-01

    This document presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. International energy and thermal and metric conversion factors are included.

  10. Monthly energy review, January 1996

    SciTech Connect

    1996-01-01

    This document presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of U.S. production, consumption, trade, stocks, and prices for petroleum,natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal metric conversion factors.

  11. Electric power monthly, March 1995

    SciTech Connect

    1995-03-20

    This report for March 1995, presents monthly electricity statistics for a wide audience including Congress, Federal and State agencies, the electric utility industry, and the general public. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead.

  12. Monthly energy review, February 1994

    SciTech Connect

    Not Available

    1994-02-24

    The Monthly Energy Review gives information on production, distribution, consumption, prices, imports, and exports for the following US energy sources: petroleum; petroleum products; natural gas; coal; electricity; and nuclear energy. The section on international energy contains data for world crude oil production and consumption, petroleum stocks in OECD countries, and nuclear electricity gross generation.

  13. Monthly energy review, December 1993

    SciTech Connect

    Not Available

    1993-12-22

    This document provides data on monthly energy use and fossil fuels. The following sections are included: Highlights: Emissions of greenhouse gases in the United States 1985--1990; Highlights: assessment of energy use in multibuilding facilities; energy overview; energy consumption; petroleum; natural gas; oil and gas resource development; coal; electricity; nuclear energy; energy prices; and international energy.

  14. Monthly energy review, March 1994

    SciTech Connect

    Not Available

    1994-03-29

    The Monthly Energy Review provides information on production, distribution, consumption, prices, imports, and exports for the following US energy sources: petroleum; petroleum products; natural gas; coal; electricity; and nuclear energy. The section on international energy contains data for world crude oil production and consumption, petroleum stocks in OECD countries, and nuclear electricity gross generation.

  15. Monthly energy review, July 1996

    SciTech Connect

    1996-07-01

    This document presents an overview of the recent monthly energy statistics from the Energy Information Administration (EIA). Statistical data covers activities of U.S. production, consumption, trade, stocks, and prices for fossil fuels , nuclear energy, and electricity. Also included are international energy and thermal and metric conversion factors.

  16. Monthly energy review, April 1997

    SciTech Connect

    1997-04-01

    This report presents an overview of monthly energy statistics. The statistics cover the major activities of U.S. production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. International energy and thermal metric conversion factors are included.

  17. Monthly energy review, October 1993

    SciTech Connect

    Not Available

    1993-10-26

    The Monthly Energy Review gives information on production, distribution, and consumption for various energy sources, e.g. petroleum, natural gas, oil, coal, electricity, and nuclear energy. Some data is also included on international energy sources and supplies, the import of petroleum products into the US and pricing and reserves data (as applicable) for the various sources of energy listed above.

  18. Natural gas monthly, December 1996

    SciTech Connect

    1996-12-01

    This document highlights activities, events, and analysis of interest to the public and private sector associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also included.

  19. Electric Power Monthly, July 1990

    SciTech Connect

    Not Available

    1990-10-12

    The Electric Power Monthly (EPM) is prepared by the Electric Power Division; Office of Coal, Nuclear, Electric and Alternate Fuels, Energy Information Administration (EIA), Department of Energy. This publication provides monthly statistics at the national, Census division, and State levels for net generation, fuel consumption, fuel stocks, quantity and quality of fuel, cost of fuel, electricity sales, and average revenue per kilowatthour of electricity sold. Data on net generation are also displayed at the North American Electric Reliability Council (NERC) region level. Additionally, company and plant level information are published in the EPM on capability of new plants, net generation, fuel consumption, fuel stocks, quantity and quality of fuel, and cost in fuel. Quantity, quality, and cost of fuel data lag the net generation, fuel consumption, fuel stocks, electricity sales, and average revenue per kilowatthour data by 1 month. This difference in reporting appears in the national, Census division, and State level tables. However, at the plant level, all statistics presented are for the earlier month for the purpose of comparison. 12 refs., 4 figs., 48 tabs.

  20. 18 CFR 367.5 - Accounting period.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Accounting period. 367.5 Section 367.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Instructions § 367.5 Accounting period. Each service company must keep its books on a monthly basis so that...

  1. 18 CFR 367.5 - Accounting period.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Accounting period. 367.5 Section 367.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Instructions § 367.5 Accounting period. Each service company must keep its books on a monthly basis so that...

  2. 18 CFR 367.5 - Accounting period.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Accounting period. 367.5 Section 367.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Instructions § 367.5 Accounting period. Each service company must keep its books on a monthly basis so that...

  3. 18 CFR 367.5 - Accounting period.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Accounting period. 367.5 Section 367.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Instructions § 367.5 Accounting period. Each service company must keep its books on a monthly basis so that...

  4. 18 CFR 367.5 - Accounting period.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Accounting period. 367.5 Section 367.5 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Instructions § 367.5 Accounting period. Each service company must keep its books on a monthly basis so that...

  5. Electric power monthly, July 1994

    SciTech Connect

    Not Available

    1994-07-01

    The Electric Power Monthly (EPM) presents monthly electricity statistics. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. Data in this report are presented for a wide audience including Congress, Federal and State agencies, the electric utility industry, and the general public. The EIA collected the information in this report to fulfill its data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 (Public Law 93-275) as amended. The EPM is prepared by the Survey Management Division; Office of Coal, Nuclear, Electric and Alternate Fuels, Energy Information Administration (EIA), Department of Energy. This publication provides monthly statistics at the US, Census division, and State levels for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of fossil fuels, electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Data on net generation, fuel consumption, fuel stocks, quantity and cost of fossil fuels are also displayed for the North American Electric Reliability Council (NERC) regions. Statistics by company and plant are published in the EPM on the capability of new generating units, net generation, fuel consumption, fuel stocks, quantity and quality of fuel, and cost of fossil fuels. Data on quantity, quality, and cost of fossil fuels lag data on net generation, fuel consumption, fuel stocks, electricity sales, and average revenue per kilowatthour by 1 month. This difference in reporting appears in the US, Census division, and State level tables. However, for purposes of comparison, plant-level data are presented for the earlier month.

  6. Petroleum supply monthly, March 1994

    SciTech Connect

    Not Available

    1994-03-30

    Data presented in the Petroleum Supply Monthly (PSM) describe the supply and disposition of petroleum products in the United States and major US geographic regions. The data series describe production, imports and exports, inter-Petroleum Administration for Defense (PAD) District movements, and inventories by the primary suppliers of petroleum products in the United States (50 States and the District of Columbia). The reporting universe includes those petroleum sectors in primary supply. Included are: petroleum refiners, motor gasoline blenders, operators of natural gas processing plants and fractionators, inter-PAD transporters, importers, and major inventory holders of petroleum products and crude oil. When aggregated, the data reported by these sectors approximately represent the consumption of petroleum products in the United States. Data presented in the PSM are divided into two sections: Summary Statistics and Detailed Statistics. The tables and figures in the Summary Statistics section of the PSM present a time series of selected petroleum data on a US level. Most time series include preliminary estimates for one month based on the Weekly Petroleum Supply Reporting System; statistics based on the most recent data from the Monthly Petroleum Supply Reporting System (MPSRS); and statistics published in prior issues of the PSM and PSA. The Detailed Statistics tables of the PSM present statistics for the most current month available as well as year-to-date. In most cases, the statistics are presented for several geographic areas -- the United States (50 States and the District of Columbia), five PAD Districts, and 12 Refining Districts. At the US and PAD District level, the total volume and the daily rate of activities are presented. The statistics are developed from monthly survey forms submitted by respondents to the EIA and from data provided from other sources.

  7. Petroleum supply monthly, June 1993

    SciTech Connect

    Not Available

    1993-06-28

    Data presented in the Petroleum Supply Monthly (PSM) describe the supply and disposition of petroleum products in the United States and major US geographic regions. The data series describe production, imports and exports, inter-Petroleum Administration for Defense (PAD) District movements, and inventories by the primary suppliers of petroleum products in the United States (50 States and the District of Columbia). The reporting universe includes those petroleum sectors in primary supply. Included are: petroleum refiners, motor gasoline blenders, operators of natural gas processing plants and fractionators, inter-PAD transporters, importers, and major inventory holders of petroleum products and crude oil. When aggregated, the data reported by these sectors approximately represent the consumption of petroleum products in the United States. Data presented in the PSM are divided into two sections: Summary Statistics and Detailed Statistics. The tables and figures ih the Summary Statistics section of the PSM present a time series of selected petroleum data on a US level. Most time series include preliminary estimates for one month based on the Weekly Petroleum Supply Reporting System; statistics based on the most recent data from the Monthly Petroleum Supply Reporting System (MPSRS); and statistics published in prior issues of the PSM and PSA. The Detailed Statistics tables of the PSM present statistics for the most current month available as well as year-to-date. In most cases, the statistics are presented for several geographic areas - - the United States (50 States and the District of Columbia), five PAD Districts, and 12 Refining Districts. At the US and PAD District level, the total volume and the daily rate of activities are presented. The statistics are developed from monthly survey forms submitted by respondents to the EIA and from data provided firom other sources.

  8. Petroleum marketing monthly, June 1994

    SciTech Connect

    Not Available

    1994-06-01

    The Petroleum Marketing Monthly (PMM) provides information and statistical data on a variety of crude oils and refined petroleum products. The publication presents statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners` acquisition cost of crude oil. Refined petroleum product sales data include motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane. Monthly statistics on purchases of crude oil and sales of petroleum products are presented in five sections: Summary Statistics; Crude Oil Prices; Prices of Petroleum Products; Volumes of Petroleum Products; and Prime Supplier Sales Volumes of Petroleum Products for Local Consumption. The feature article is entitled ``The Second Oxygenated Gasoline Season.`` 7 figs., 50 tabs.

  9. Monthly energy review, March 1998

    SciTech Connect

    1998-03-01

    The Monthly Energy Review (MER) presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of U.S. production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. Energy production during December 1997 totaled 5.9 quadrillion Btu, a 2.8 percent increase from the level of production during December 1996. Coal production increased 9.5 percent, natural gas production increased 3.9 percent, and production of crude oil and natural gas plant liquids decreased 1.1 percent. All other forms of energy production combined were down 6.9 percent from the level of production during December 1996.

  10. Petroleum marketing monthly, July 1994

    SciTech Connect

    Not Available

    1994-07-01

    The Petroleum Marketing Monthly (PMM) provides information and statistical data on a variety of crude oils and refined petroleum products. The publication presents statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners` acquisition cost of crude oil. Refined petroleum product sales data include motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane. Monthly statistics on purchases of crude oil and sales of petroleum products are presented in five sections: summary statistics; crude oil prices; prices of petroleum products; volumes of petroleum products; and prime supplier sales volumes of petroleum products for local consumption. 7 figs., 50 tabs.

  11. Petroleum marketing monthly, September 1994

    SciTech Connect

    Not Available

    1994-09-01

    The Petroleum Marketing Monthly (PMM) provides information and statistical data on a variety of crude oils and refined petroleum products. The publication presents statistics on crude oil costs and refined petroleum product sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners` acquisition cost of crude oil. Refined petroleum product sales data include motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane. The Petroleum Marketing Division, Office of Oil and Gas, Energy Information Administration ensures the accuracy, quality, and confidentiality of the published data in the Petroleum Marketing Monthly.

  12. Natural gas monthly, October 1991

    SciTech Connect

    Not Available

    1991-11-05

    The Natural Gas Monthly (NGM) is prepared in the Data Operations Branch of the Reserves and Natural Gas Division, Office of Oil and Gas, Energy Information Administration (EIA), US Department of Energy (DOE). The NGM highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. The data in this publication are collected on surveys conducted by the EIA to fulfill its responsibilities for gathering and reporting energy data. Some of the data are collected under the authority of the Federal Energy Regulatory Commission (FERC), an independent commission within the DOE, which has jurisdiction primarily in the regulation of electric utilities and the interstate natural gas industry. Geographic coverage is the 50 States and the District of Columbia. 16 figs., 33 tabs.

  13. Natural Gas Monthly August 1998

    SciTech Connect

    1998-08-01

    The Natural Gas Monthly (NGM) highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information. Explanatory notes supplement the information found in tables of the report. A description of the data collection surveys that support the NGM is provided. A glossary of the terms used in this report is also provided to assist readers in understanding the data presented in this publication.

  14. Petroleum marketing monthly, August 1994

    SciTech Connect

    Not Available

    1994-08-15

    The Petroleum Marketing Monthly (PMM) provides information and statistical data on a variety of crude oils and refined petroleum products. The publication presents statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners` acquisition cost of crude oil. Refined petroleum product Sales data include motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane. The Petroleum Marketing Division, Office of Oil and Gas, Energy Information Administration ensures the accuracy, quality, and confidentiality of the published data in the Petroleum Marketing Monthly.

  15. Natural gas monthly, May 1995

    SciTech Connect

    1995-05-24

    The NGM highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  16. Natural gas monthly, February 1996

    SciTech Connect

    1996-03-01

    The NGM highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. From time to time, the NGM features articles designed to assist readers in using and interpreting natural gas information.

  17. Laser fusion monthly -- August 1980

    SciTech Connect

    Ahlstrom, H.G.

    1980-08-01

    This report documents the monthly progress for the laser fusion research at Lawrence Livermore National Laboratory. First it gives facilities report for both the Shiva and Argus projects. Topics discussed include; laser system for the Nova Project; the fusion experiments analysis facility; optical/x-ray streak camera; Shiva Dante System temporal response; 2{omega}{sub 0} experiment; and planning for an ICF engineering test facility.

  18. Electric power monthly, May 1996

    SciTech Connect

    1996-05-01

    This publication presents monthly electricity statistics for a wide audience including Congress, Federal and Stage agencies, the electric utility industry, and the general public. Purpose is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. EIA collected the information to fulfill its data collection and dissemination responsibilities in Federal Energy Administration Act of 1974 (Public Law 93-275) as amended.

  19. Natural gas monthly, February 1994

    SciTech Connect

    Not Available

    1994-02-25

    The NGM highlights activities, events, and analyses of interest to public and private sector organizations associated with the natural gas industry. Volume and price data are presented each month for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. The NGM also features articles designed to assist readers in using and interpreting natural gas information.

  20. Natural gas monthly, March 1998

    SciTech Connect

    1998-03-01

    The March 1998 edition of the Natural Gas Monthly highlights activities, events, and analyses associated with the natural gas industry. Volume and price data are presented for natural gas production, distribution, consumption, and interstate pipeline activities. Producer-related activities and underground storage data are also reported. This report also features an article on the correction of errors in the drilling activity estimates series, and in-depth drilling activity data. 6 figs., 28 tabs.

  1. Introducing 'Image of the Month'

    NASA Astrophysics Data System (ADS)

    Brian, Jones

    2016-04-01

    The Editors of Sedimentary Geology are pleased to announce the establishment of an 'Image of the Month', to appear in each issue of the journal. The idea is to publish outstanding examples of sedimentary features, at all scales, as a means of increasing their visibility and so promoting further discussion and exchange of ideas within the community. The image could be at the scale of satellite image, aerial photograph, outcrop, specimen or thin section.

  2. Monthly energy review, October 1997

    SciTech Connect

    1997-10-01

    This document presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of U.S. production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Information is also provided for oil and gas resource development. International energy statistics are given for petroleum production, consumption, and stocks, and for nuclear electricity gross generation. 37 figs., 61 tabs.

  3. Mineral of the month: magnesium

    USGS Publications Warehouse

    Kramer, Deborah A.

    2005-01-01

    Magnesium, often confused with last month’s mineral of the month manganese, is valued primarily because of its light weight and high strength-to-weight ratio. Magnesium is the eighth most abundant element and constitutes about 2 percent of the Earth’s crust. It is the third most plentiful element dissolved in seawater, with a concentration averaging 0.13 percent. Magnesium is found in over 60 minerals, and also is recovered from seawater, wells, and lake brines and bitterns.

  4. Electric Power monthly, November 1996

    SciTech Connect

    1996-11-01

    This publication presents monthly electricity statistics for a wide audience including Congress, Federal and state agencies, the electric utility industry, and the general public. Purpose is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. EIA collected the information in this report to fulfill its data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 (Public Law 93-275) as amended.

  5. Monthly energy review, December 1995

    SciTech Connect

    1995-12-21

    This publication presents an overview of EIA`s recent monthly energy statistics. The statistics cover the major activities of US production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Also included are international energy and thermal and metric conversion factors. An energy preview of alternative fuel providers vehicle fleet surveys is included. The publication is intended for use by members of Congress, Federal and State agencies, energy analysts, and the general public.

  6. Electric Power Monthly, June 1990

    SciTech Connect

    Not Available

    1990-09-13

    The EPM is prepared by the Electric Power Division; Office of Coal, Nuclear, Electric and Alternate Fuels, Energy Information Administration (EIA), Department of Energy. This publication provides monthly statistics at the national, Census division, and State levels for net generation, fuel consumption, fuel stocks, quantity and quality of fuel, electricity sales, and average revenue per kilowatthour of electricity sold. Data on net generation are also displayed at the North American Electric Reliability Council (NERC) region level. Additionally, company and plant level information are published in the EPM on capability of new plants, net generation, fuel consumption, fuel stocks, quantity and quality of fuel, and cost of fuel. Quantity, quality, and cost of fuel data lag the net generation, fuel consumption, fuel stocks, electricity sales, and average revenue per kilowatthour data by 1 month. This difference in reporting appears in the national, Census division, and State level tables. However, at the plant level, all statistics presented are for the earlier month for the purpose of comparison. 40 tabs.

  7. Electric power monthly, January 1994

    SciTech Connect

    Not Available

    1994-01-26

    The Electric Power Monthly (EPM) presents monthly electricity statistics. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. Data in this report are presented for a wide audience including Congress, Federal and State agencies, the electric utility industry, and the general public. The EIA collected the information in this report to fulfill its data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 (Public Law 93-275) as amended. This publication provides monthly statistics at the US Census division, and State levels for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of fossil fuels, electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Data on net generation, fuel consumption, fuel stocks, quantity and cost of fossil fuels are also displayed for the North American Electric Reliability Council (NERC) regions. Statistics by company and plant are published in the EPM on the capability of new generating units, net generation, fuel consumption, fuel stocks, quantity and quality of fuel, and cost of fossil fuels.

  8. Electric power monthly, February 1994

    SciTech Connect

    Not Available

    1994-02-16

    The Electric Power Monthly (EMP) presents monthly electricity statistics. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. Data in this report are presented for a wide audience including Congress, Federal and State agencies, the electric utility industry, and the general public. The EIA collected the information in this report to fulfill its data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 (Public Law 93-275) as amended. This publication provides monthly statistics at the US, Census division, and State levels for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Data on net generation, fuel consumption, fuel stocks, quantity and cost of fossil fuels are also displayed for the North American Electric Reliability Council (NERC) regions. Statistics by company and plant are published in the EPM on the capability of new generating units, net generation, fuel consumption, fuel stocks, quantity and quality of fuel, and cost of fossil fuels.

  9. Electric power monthly, October 1993

    SciTech Connect

    Not Available

    1993-10-20

    The Electric Power Monthly (EPM) presents monthly electricity statistics. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. Data in this report are presented for a wide audience including Congress, Federal and State agencies, the electric utility industry, and the general public. The EIA collected the information in this report to fulfill its data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 (Public Law 93-275) as amended. This publication provides monthly statistics at the US, Census division, and State levels for net generation, fossil fuel consumption and stocks, quantity and quality of fossil fuels, cost of fossil fuels, electricity sales, revenue, and average revenue per kilowatthour of electricity sold. Data on net generation, fuel consumption, fuel stocks, quantity and cost of fossil fuels are also displayed for the North American Electric Reliability Council (NERC) regions. Statistics by company and plant are published in the EPM on the capability of new generating units, net generation, fuel consumption, fuel stocks, quantity and quality of fuel, and cost of fossil fuels.

  10. Localization of vacancies and mobility of lithium ions in Li2ZrO3 as obtained by 6,7Li NMR

    NASA Astrophysics Data System (ADS)

    Baklanova, Ya. V.; Arapova, I. Yu.; Buzlukov, A. L.; Gerashenko, A. P.; Verkhovskii, S. V.; Mikhalev, K. N.; Denisova, Т. А.; Shein, I. R.; Maksimova, L. G.

    2013-12-01

    The 6,7Li NMR spectra and the 7Li spin-lattice relaxation rate were measured on polycrystalline samples of Li2ZrO3, synthesized at 1050 K and 1300 K. The 7Li NMR lines were attributed to corresponding structural positions of lithium Li1 and Li2 by comparing the EFG components with those obtained in the first-principles calculations of the charge density in Li2ZrO3. For both samples the line width of the central 7Li transition and the spin-lattice relaxation time decrease abruptly at the temperature increasing above ~500 K, whereas the EFG parameters are averaged (<νQ>=42 (5) kHz) owing to thermally activated diffusion of lithium ions.

  11. Crystal structure of disodium 2-amino-6-oxo-6,7-di­hydro-1H-purine-1,7-diide hepta­hydrate

    PubMed Central

    Gur, Dvir; Shimon, Linda J. W.

    2015-01-01

    In the title compound, disodium 2-amino-6-oxo-6,7-di­hydro-1H-purine-1,7-diide hepta­hydrate, 2Na+·C5H3N5O2−·7H2O, the structure is composed of alternating (100) layers of guanine mol­ecules and hydrated Na+ ions. Within the guanine layer, the mol­ecules are arranged in centrosymmetric pairs, with a partial overlap between the guanine rings. In this compound, guanine exists as the amino–keto tautomer from which deprotonation from N1 and N7 has occurred (purine numbering). There are no direct inter­actions between the Na+ cations and the guanine anions. Guanine mol­ecules are linked to neighboring water mol­ecules by O—H⋯N and O—H⋯O hydrogen bonds into a network structure. PMID:25844188

  12. A Comprehensive Theoretical Analysis of 6,7Li + 64Zn Elastic Scattering in a Wide Angular Range Around the Coulomb Barrier

    NASA Astrophysics Data System (ADS)

    Ibraheem, Awad A.; Aygun, M.

    2016-06-01

    In this paper, the elastic scattering angular distributions of 6,7Li on 64Zn have been investigated by using various nuclear potentials. For this, we use the phenomenological Woods-Saxon potential, the real double folding potential with the density-independent M3Y effective interaction supplemented with an imaginary part in Woods-Saxon form and the double folding potentials multiplied with a normalization factor of the real and imaginary parts via the density-independent and CDM3Y6 density-dependent versions of the M3Y effective interaction have been used. The results have been compared with each other as well as with the experimental data. It has been observed that the agreement between the theoretical results and earlier reported data is perfect. Finally, the change of the total reaction cross sections with energy has been investigated.

  13. Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.

    PubMed

    Liao, Shixian; Deng, Hui; Huang, Shengbin; Yang, Jingyuan; Wang, Siqian; Yin, Baodi; Zheng, Tieli; Zhang, Dafeng; Liu, Jinsong; Gao, Guohui; Ma, Jianfeng; Deng, Zhennan

    2015-04-01

    A series of 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease (AD). The results showed that the target compounds exhibited good acetylcholinesterase (AChE) inhibitory potencies, high selectivity toward AChE over butyrylcholinesterase (BuChE), potential antioxidant activities and significant inhibitory potencies of self-induced beta-amyloid peptide (Aβ) aggregation. In particular, compound 14c had the strongest AChE inhibitory activity with IC50 value of 12.8 nM, potent inhibition of self-induced Aβ1-42 aggregation with inhibition ratio of 33.8% at 25 μM. Moreover, compound 14c acted as an antioxidant, as well as a neuroprotectant. Furthermore, 14c could cross the blood-brain barrier (BBB) in vitro. The results showed that compound 14c might be a potential multifunctional candidate for the treatment of AD. PMID:25724825

  14. Tetra(1,1,4,4-tetramethyl-6,7-tetralino)porphyrazine as a novel luminescence sensor of laser-induced singlet oxygen generation in solutions

    SciTech Connect

    Krasnovskii, A A; Schweitzer, C; Leismann, H; Tanielian, C; Luk'yanets, Evgenii A

    2000-05-31

    Absorption and fluorescence spectra and quantum yields of fluorescence and singlet oxygen generation were studied in air-saturated solutions of a newly synthesised dye, tetra(1,1,4,4-tetramethyl-6,7-tetralino)porphyrazine (TMTP), in benzene. Photophysical properties of TMTP are similar to those of previously studied tetra(4-tert-butyl) phthalocyanine (TBPc). However, the TMTP absorption and fluorescence bands are shifted to the longer wavelengths compared with those of TBPc. The laser-induced generation of singlet molecular oxygen {sup 1}O{sub 2} in TMTP solutions caused strong singlet oxygen-sensitised delayed fluorescence of the dye. The efficiency of singlet-oxygen-sensitised formation of excited TMTP molecules is two times higher than that of TBPc. It is shown that TMTP can serve as an efficient luminescence sensor of singlet oxygen. (laser applications and other topics in quantum electronics)

  15. [Regulation of the activity and synthesis of enzymes participating in the formation of 6,7-dimethyl-8-ribityllumazine, a riboflavin precursor in yeast].

    PubMed

    Logvinenko, E M; Shavlovskiĭ, G M; Zakal'skiĭ, A E; Samarskiĭ, V A

    1989-01-01

    The properties of two flavinogenesis enzymes--synthase of the aliphatic precursor of riboflavin (APR-synthase) and 6.7-dimethyl-8-ribityllumazinesynthase (DMRL-synthase) of Pichia guilliermondii. It is established that DMRL-synthase, uses APR as a substrate which contains, evidently, a phosphate group. The value of Km for APR is equal to 0.7.10(-5) M, for 2.4-dihydroxy-5-amino-6-ribitylaminopyrimidine--1.25.10(-5) M. It is riboflavin but not FAD that inhibits the activity of DMRL-synthase; the value (I)0.5 is equal to 2.10(-5) M. DMRL, riboflavin, flavin mononucleotide and FAD do not affect the APR-synthase activity. In iron-deficient cells of P. guilliermondii, Torulopsis candida, Debaryomyces klöckeri and Schwanniomyces occidentalis realizing the oversynthesis of riboflavin there occurs derepression of DMRL-synthase and APR-synthase. PMID:2741238

  16. Aerodynamic heating and loading within large open cavities in cone and cone-cylinder-flare models at Mach 6.7

    NASA Technical Reports Server (NTRS)

    Hunt, R. L.

    1974-01-01

    The aerodynamic heating and loading distributions within large cavities exposed by surface openings to hypersonic flow were determined in the 8-foot high-temperature structures tunnel. Cone and cone-cylinder-flare models with cavities having regular and irregular surface-opening shapes were aerothermally tested at various angles of attack up to 30 deg. Tests were conducted at a Mach number of 6.7, a total temperature of 1800 K, a dynamic pressure of 80 kPa, and a stream unit Reynolds number of 6,000,000 per meter. The results showed that the heating rates at internal reattachment were generally lower but of the same order as the corresponding external heating rates; however, other internal heating rates were an order of magnitude lower. The internal flow showed characteristics of being funneled into jets or being dispersed dependent upon the internal surface contour.

  17. Coherence properties of a 2.6-7.5  μm frequency comb produced as a subharmonic of a Tm-fiber laser.

    PubMed

    Smolski, V O; Yang, H; Gorelov, S D; Schunemann, P G; Vodopyanov, K L

    2016-04-01

    We study the temporal coherence of an ultrabroadband frequency comb produced in a degenerate GaAs optical parametric oscillator (OPO) pumped by a stabilized Tm-fiber comb, by observing multiheterodyne beats in the RF domain. We infer that in such a regime the OPO automatically produces a stable frequency comb that is phase and frequency locked to the pump. By varying intracavity dispersion, we achieve a comb spanning 2.6-7.5 μm at a -20  dB level. Low pump threshold (down to 7 mW), high average power (up to 73 mW), broad spectral coverage, flat spectrum, and high coherence make this comb a source suitable for various applications, foremost dual-comb molecular spectroscopy. PMID:27192243

  18. Benzophenanthridines. V. Investigation of the Rodionov-Suvorov scheme. Synthesis of 3,3-diethoxycarbonyl-2-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1-tetralone

    SciTech Connect

    Kyong, D.H.; Sladkov, V.I.; Suvorov, N.N.

    1988-02-20

    Triethyl 1,3-bis(3,4-dimethoxyphenyl)propane-1,2,2-tricarboxylate was synthesized by the alkylation of the lithium enolate of ethyl homoveratrate with /alpha/-bromo(3,4-dimethoxybenzyl)malonic ester. It was converted by intramolecular acylation, catalyzed by BF/sub 3/ /times/ OEt/sub 2/, into the ACD synthon for the total synthesis of benzo(c)-phenanthridine alkaloids by the Rodionov-Suvorov scheme, i.e., 3,3-diethoxy-carbonyl-2-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1-tetralone. The structure of the synthesized substances agrees well with the data from elemental analysis and IR, /sup 1/H NMR, and mass spectra.

  19. Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).

    PubMed

    Takai, Takafumi; Koike, Tatsuki; Nakamura, Minoru; Kajita, Yuichi; Yamashita, Toshiro; Taya, Naohiro; Tsukamoto, Tetsuya; Watanabe, Tomomichi; Murakami, Koji; Igari, Tomoko; Kamata, Makoto

    2016-07-15

    γ-Secretase modulators (GSMs), which lower pathogenic amyloid beta (Aβ) without affecting the production of total Aβ or Notch signal, have emerged as a potential therapeutic agent for Alzheimer's disease (AD). A novel series of 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives was discovered and characterized as GSMs. Optimization of substituents at the 8-position of the core scaffold using ligand-lipophilicity efficiency (LLE) as a drug-likeness guideline led to identification of various types of high-LLE GSMs. Phenoxy compound (R)-17 exhibited especially high LLE as well as potent in vivo Aβ42-lowering effect by single administration. Furthermore, multiple oral administration of (R)-17 significantly reduced soluble and insoluble brain Aβ42, and ameliorated cognitive deficit in novel object recognition test (NORT) using Tg2576 mice as an AD model. PMID:27255179

  20. Biochemical and Structural Studies of 6-Carboxy-5,6,7,8-tetrahydropterin Synthase Reveal the Molecular Basis of Catalytic Promiscuity within the Tunnel-fold Superfamily*

    PubMed Central

    Miles, Zachary D.; Roberts, Sue A.; McCarty, Reid M.; Bandarian, Vahe

    2014-01-01

    6-Pyruvoyltetrahydropterin synthase (PTPS) homologs in both mammals and bacteria catalyze distinct reactions using the same 7,8-dihydroneopterin triphosphate substrate. The mammalian enzyme converts 7,8-dihydroneopterin triphosphate to 6-pyruvoyltetrahydropterin, whereas the bacterial enzyme catalyzes the formation of 6-carboxy-5,6,7,8-tetrahydropterin. To understand the basis for the differential activities we determined the crystal structure of a bacterial PTPS homolog in the presence and absence of various ligands. Comparison to mammalian structures revealed that although the active sites are nearly structurally identical, the bacterial enzyme houses a His/Asp dyad that is absent from the mammalian protein. Steady state and time-resolved kinetic analysis of the reaction catalyzed by the bacterial homolog revealed that these residues are responsible for the catalytic divergence. This study demonstrates how small variations in the active site can lead to the emergence of new functions in existing protein folds. PMID:24990950

  1. Anti-KEL7 (anti-Js(b)) alloimmunization diagnostic supported by molecular KEL*6,7 typing in a pregnant woman with previous intrauterine deaths.

    PubMed

    Boturão-Neto, Edmir; Chiba, Akemi Kuroda; Oliveira Barros, Melca Maria; Barretto de Mello, Adriana; Fabron, Antonio; Orlando Bordin, José

    2006-12-01

    Anti-KEL7 (anti-Js(b)) is a rare antibody that has been related to haemolytic transfusion reactions and HDN. We report a case of anti-KEL7 alloimmunization detected in a pregnant woman who had an obstetric previous history of four miscarriages and one stillborn. Employing classical immunohematological techniques, we studied the propositus and her available relatives. Due to the unavailability of commercial anti-KEL6 and anti-KEL7 reagents, we used a KEL*6,7 genotyping method as an alternative tool to contribute with the identification of the alloantibody origin. The results of KEL genotyping showed that the propositus was KEL*6/6 homozygous, while her second partner was KEL*7/7 homozygous. PMID:17097348

  2. Craniosynostosis and hemizygosity for D7S135 caused by a de novo and apparently balanced t(6;7) translocation

    SciTech Connect

    Tsuji, Kazushiro; Narahara, Kouji; Kikkawa, Kiyoshi; Murakami, Masae; Yokoyama, Yuji; Ninomiya, Shinsuke; Seino, Yoshiki

    1994-01-01

    Craniosynostosis (CRS) is frequently seen in the del(7p) syndrome, and the gene for this cranial anomaly (CRS1) has been assigned to 7p21. The authors present a 3-year-old boy with CRS involving the sagittal and coronal sutures, who had a de novo and apparently balanced translocation, t(6;7)(q16.2;p15.3). Southern blot analysis of several loci on 7p14{yields}pter showed that the patient was heterozygous for HOX1I and IL6, possibly homozygous for D7S149, but hemizygous for D7S135 with a loss of the paternal allele. These findings suggest the localization of a candidate gene for CRS1 to be on 7p15.3 in the close proximity to the D7S135 locus. 19 refs., 5 figs., 2 tabs.

  3. A Comprehensive Theoretical Analysis of 6,7Li + 64Zn Elastic Scattering in a Wide Angular Range Around the Coulomb Barrier

    NASA Astrophysics Data System (ADS)

    Ibraheem, Awad A.; Aygun, M.

    2016-08-01

    In this paper, the elastic scattering angular distributions of 6,7Li on 64Zn have been investigated by using various nuclear potentials. For this, we use the phenomenological Woods-Saxon potential, the real double folding potential with the density-independent M3Y effective interaction supplemented with an imaginary part in Woods-Saxon form and the double folding potentials multiplied with a normalization factor of the real and imaginary parts via the density-independent and CDM3Y6 density-dependent versions of the M3Y effective interaction have been used. The results have been compared with each other as well as with the experimental data. It has been observed that the agreement between the theoretical results and earlier reported data is perfect. Finally, the change of the total reaction cross sections with energy has been investigated.

  4. Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives.

    PubMed

    Bassin, Jatinder P; Anagani, Bhavani; Benham, Christopher; Goyal, Madhu; Hashemian, Maryam; Gerhard, Ute

    2016-01-01

    A simple synthetic route affording 27%-85% yields of benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring systems from readily available 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline starting materials in toluene and catalysed by p-toluene-sulfonic acid is developed. The ¹H- and (13)C-NMR spectra of the final products were assigned using a variety of one and two-dimensional NMR experiments. The distinction between the two potential isomers of the final products was made on the basis of heteronuclear multiple bond connectivity (HMBC) NMR spectra. PMID:27455232

  5. Gut Bifidobacterium microbiota in one-month-old Brazilian newborns.

    PubMed

    Grześkowiak, Łukasz; Sales Teixeira, Tatiana Fiche; Bigonha, Solange Mara; Lobo, Guilherme; Salminen, Seppo; Ferreira, Celia Lucia de Luces Fortes

    2015-10-01

    Gut colonisation with bifidobacteria in early infancy is essential for the well-being of the infant. Gestational age and mode of delivery are among the factors influencing the colonisation process. The aim was to characterise the bifidobacterial composition in the gut of one-month-old full-term and pre-term Brazilian infants, both being delivered vaginally or by caesarean section. Fourty nine Brazilian (Viçosa, Minas Gerais state) one-month-old infants were divided in two groups: full-term (n = 24) and pre-term (n = 25), and compared to each other. Each group was then characterised according to its mode of delivery. Infant stool samples were available for bifidobacterial characterisation by quantitative polymerase chain reaction (qPCR) method. All study infants were colonised by bifidobacteria. Bifidobacterium longum colonised all full-term and pre-term newborns. Differences were observed in counts of Bifidobacterium genus and Bifidobacterium longum between full-term and pre-term infants (8.8 log cells/g, IQR 7.9-9.1 vs. 7.1 log cells/g, IQR 6.6-8.6, p = 0.02 and 8.3 log cells/g, IQR 6.7-9.1 vs. 6.4 log cells/g, IQR 6.1-6.7, p = 0.001, respectively). Furthermore, the prevalence of Bifidobacterium lactis differed between pre-term caesarean and pre-term vaginally born infants (50.0% vs. 93.8%, p = 0.023). Gut bifidobacterial composition of one-month-old full-term infants differs from that of pre-term newborns in Viçosa, Minas Gerais state, Brazil. Gestational age is a factor influencing bacterial numbers and species, while mode of delivery have an impact on the prevalence and quantity of bifidobacteria in studied infants. Bifidobacteria may have an impact on later health of the infants and the species B. longum and B. lactis might provide clues on the potential probiotic applications in pre-term newborns at the risk of developing postnatal complications. PMID:26204793

  6. 26 CFR 2.1-21 - Period for construction of certain vessels.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... purchased from the Administration must, within six months from the date of the construction contract, or... six months' period from the date of the contract or within the period of any extension, and...

  7. 26 CFR 2.1-21 - Period for construction of certain vessels.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... purchased from the Administration must, within six months from the date of the construction contract, or... six months' period from the date of the contract or within the period of any extension, and...

  8. Evolution of periodicity in periodical cicadas

    PubMed Central

    Ito, Hiromu; Kakishima, Satoshi; Uehara, Takashi; Morita, Satoru; Koyama, Takuya; Sota, Teiji; Cooley, John R.; Yoshimura, Jin

    2015-01-01

    Periodical cicadas (Magicicada spp.) in the USA are famous for their unique prime-numbered life cycles of 13 and 17 years and their nearly perfectly synchronized mass emergences. Because almost all known species of cicada are non-periodical, periodicity is assumed to be a derived state. A leading hypothesis for the evolution of periodicity in Magicicada implicates the decline in average temperature during glacial periods. During the evolution of periodicity, the determinant of maturation in ancestral cicadas is hypothesized to have switched from size dependence to time (period) dependence. The selection for the prime-numbered cycles should have taken place only after the fixation of periodicity. Here, we build an individual-based model of cicadas under conditions of climatic cooling to explore the fixation of periodicity. In our model, under cold environments, extremely long juvenile stages lead to extremely low adult densities, limiting mating opportunities and favouring the evolution of synchronized emergence. Our results indicate that these changes, which were triggered by glacial cooling, could have led to the fixation of periodicity in the non-periodical ancestors. PMID:26365061

  9. Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity

    PubMed Central

    Chen, Yi-Fong; Lin, Yi-Chien; Morris-Natschke, Susan L; Wei, Chen-Fang; Shen, Ting-Chen; Lin, Hui-Yi; Hsu, Mei-Hua; Chou, Li-Chen; Zhao, Yu; Kuo, Sheng-Chu; Lee, Kuo-Hsiung; Huang, Li-Jiau

    2015-01-01

    Background and Purpose 4-Phenylquinolin-2(1H)-one (4-PQ) derivatives can induce cancer cell apoptosis. Additional new 4-PQ analogs were investigated as more effective, less toxic antitumour agents. Experimental Approach Forty-five 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives were synthesized. Antiproliferative activities were evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliun bromide assay and structure–activity relationship correlations were established. Compounds 9b, 9c, 9e and 11e were also evaluated against the National Cancer Institute-60 human cancer cell line panel. Hoechst 33258 and Annexin V-FITC/PI staining assays were used to detect apoptosis, while inhibition of microtubule polymerization was assayed by fluorescence microscopy. Effects on the cell cycle were assessed by flow cytometry and on apoptosis-related proteins (active caspase-3, -8 and -9, procaspase-3, -8, -9, PARP, Bid, Bcl-xL and Bcl-2) by Western blotting. Key Results Nine 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives (7e, 8e, 9b, 9c, 9e, 10c, 10e, 11c and 11e) displayed high potency against HL-60, Hep3B, H460, and COLO 205 cancer cells (IC50 < 1 μM) without affecting Detroit 551 normal human cells (IC50 > 50 μM). Particularly, compound 11e exhibited nanomolar potency against COLO 205 cancer cells. Mechanistic studies indicated that compound 11e disrupted microtubule assembly and induced G2/M arrest, polyploidy and apoptosis via the intrinsic and extrinsic signalling pathways. Activation of JNK could play a role in TRAIL-induced COLO 205 apoptosis. Conclusion and Implications New quinolone derivatives were identified as potential pro-apoptotic agents. Compound 11e could be a promising lead compound for future antitumour agent development. PMID:25363404

  10. Petroleum marketing monthly, November 1993

    SciTech Connect

    Not Available

    1993-11-09

    The Petroleum Marketing Monthly (PMM) is designed to give information and statistical data about a variety of crude oils and refined petroleum products. The publication provides statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed costs of imported crude oil, and the refiner`s acquisition cost of crude oil. Sales data for motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane are presented.

  11. Petroleum marketing monthly, March 1994

    SciTech Connect

    Not Available

    1994-03-22

    The Petroleum Marketing Monthly is designed to give information and statistical data about a variety of crude oils and refined petroleum products. The publication provides statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, education institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiner`s acquisition cost of crude oil. Sales data for motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane are presented.

  12. Petroleum marketing monthly, January 1994

    SciTech Connect

    Not Available

    1994-02-01

    The Petroleum Marketing Monthly (PMM) is designed to give information and statistical data about a variety of crude oils and refined petroleum products. The publication provides statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners` acquisition cost of crude oil. Sales data for motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane are presented.

  13. Petroleum marketing monthly, February 1994

    SciTech Connect

    Not Available

    1994-02-25

    The Petroleum Marketing Monthly is designed to give information and statistical data about a variety of crude oils and refined petroleum products. The publication provides statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiner`s acquisition cost of crude oil. Sales data for motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane are presented.

  14. Petroleum marketing monthly, August 1993

    SciTech Connect

    Not Available

    1993-08-10

    The Petroleum Marketing Monthly (PMM) is designed to give information and statistical data about a variety of crude oils and refined petroleum products. The publication provides statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners` acquisition cost of crude oil. Sales data for motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane are presented.

  15. Petroleum marketing monthly, April 1994

    SciTech Connect

    Not Available

    1994-04-12

    The Petroleum Marketing Monthly (PMM) is designed to give information and statistical data about a variety of crude oils and refined petroleum products. The publication provides statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners` acquisition cost of crude oil. Sales data for motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane are presented.

  16. Petroleum marketing monthly, July 1993

    SciTech Connect

    Not Available

    1993-07-15

    The Petroleum Marketing Monthly (PMM) is designed to give information and statistical data about a variety of crude oils and refined petroleum products. The publication provides statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners` acquisition cost of crude oil. Sales data for motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane are presented.

  17. Petroleum marketing monthly, August 1990

    SciTech Connect

    Not Available

    1990-11-07

    The Petroleum Marketing Monthly (PMM) is designed to give information and statistical data about a variety of crude oils and refined petroleum products. The publication provides statistics on crude oil costs and refined petroleum products sales for use by industry, government, private sector analysts, educational institutions, and consumers. Data on crude oil include the domestic first purchase price, the f.o.b. and landed cost of imported crude oil, and the refiners' acquisition cost of crude oil. Sales data for motor gasoline, distillates, residuals, aviation fuels, kerosene, and propane are presented. 12 figs., 49 tabs.

  18. Monthly energy review, September 1997

    SciTech Connect

    1997-09-01

    This publication presents an overview of the Energy Information Administration`s recent monthly energy statistics. The statistics cover the major activities of U.S. production, consumption, trade, stocks, and prices for petroleum, natural gas, coal, electricity, and nuclear energy. Information is also provided on international energy, including petroleum production, consumption, and stocks and nuclear electricity gross generation. This issues provides a brief industry overview and a detailed analysis of the spring 1996 gasoline price runup, crude oil supply issues, U.S. crude oil imports, petroleum stocks, futures markets, refining cash margin trends, and the financial performance of U.S. refining and marketing firms. 37 figs., 73 tabs.

  19. Petroleum supply monthly: December 1993

    SciTech Connect

    Not Available

    1993-12-01

    Data are presented which describe the supply and disposition of petroleum products in the United States and major U.S. geographic regions. The data series describe production, imports and exports, inter-Petroleum Administration for Defense (PAD) District movements, and inventories by the primary suppliers of petroleum products in the United States. Data are presented in two sections: Summary Statistics, presenting a time series of selected petroleum data on a U.S. level, and Detailed Statistics, presenting statistics for the most current month available as well as year to date.

  20. Petroleum supply monthly, April 1994

    SciTech Connect

    Not Available

    1994-04-01

    Data presented in the Petroleum Supply Monthly (PSM) describe the supply and disposition of petroleum products in the United States and major US geographical regions. The data series describe production, imports and exports, inter-Petroleum Administration for Defense (PAD) District movements, and inventories by the primary suppliers of petroleum products in the US. The reporting universe includes those petroleum sectors in primary supply. Included are: petroleum refiners, motor gasoline blenders, operators of natural gas processing plants and fractionators, inter-PAD transporters, importers, and major inventory holders of petroleum products and crude oil. When aggregated, the data reported by these sectors approximately represent the consumption of petroleum products in the US.